Search of human proteins with 4557896

Search of human proteins with 4557896

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557896 myotubularin [Homo sapiens]
         (603 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557896 myotubularin [Homo sapiens]                               1231   0.0  
gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]   800   0.0  
gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]   798   0.0  
gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]   798   0.0  
gi|28872761 myotubularin-related protein 1 [Homo sapiens]             728   0.0  
gi|134142348 myotubularin related protein 6 [Homo sapiens]            360   3e-99
gi|21361759 myotubularin related protein 8 [Homo sapiens]             358   6e-99
gi|225543474 myotubularin related protein 7 [Homo sapiens]            346   3e-95
gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]   335   9e-92
gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]   335   9e-92
gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]   335   9e-92
gi|217272865 myotubularin related protein 4 [Homo sapiens]            327   2e-89
gi|19923424 myotubularin related protein 9 [Homo sapiens]             297   2e-80
gi|124028527 myotubularin related protein 10 [Homo sapiens]           154   2e-37
gi|29788755 SET binding factor 2 [Homo sapiens]                       145   8e-35
gi|239735519 SET binding factor 1 [Homo sapiens]                      141   2e-33
gi|94721263 myotubularin related protein 12 [Homo sapiens]            135   8e-32
gi|224994251 myotubularin related protein 11 isoform a [Homo sap...   127   2e-29
gi|89111941 myotubularin related protein 11 isoform b [Homo sapi...   127   2e-29
gi|117938274 jumpy isoform 3 [Homo sapiens]                            45   3e-04
gi|117938272 jumpy isoform 1 [Homo sapiens]                            45   3e-04
gi|117938270 jumpy isoform 2 [Homo sapiens]                            45   3e-04
gi|4503417 dual specificity phosphatase 4 isoform 1 [Homo sapiens]     37   0.068
gi|16950652 dual specificity phosphatase 4 isoform 2 [Homo sapiens]    37   0.068
gi|238231453 dual specificity phosphatase 7 [Homo sapiens]             34   0.34 
gi|42764683 dual specificity phosphatase 6 isoform a [Homo sapiens]    33   0.58 
gi|4503421 dual specificity phosphatase 9 [Homo sapiens]               33   0.58 
gi|148728162 protein tyrosine phosphatase, receptor type, J isof...    33   0.75 
gi|38261971 cyclic AMP-regulated phosphoprotein, 21 kD isoform 1...    32   1.7  
gi|38372911 dual specificity phosphatase 16 [Homo sapiens]             32   2.2  

>gi|4557896 myotubularin [Homo sapiens]
          Length = 603

 Score = 1231 bits (3185), Expect = 0.0
 Identities = 603/603 (100%), Positives = 603/603 (100%)

Query: 1   MASASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLITDKEVIYICPFNGPIK 60
           MASASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLITDKEVIYICPFNGPIK
Sbjct: 1   MASASTSKYNSHSLENESIKRTSRDGVNRDLTEAVPRLPGETLITDKEVIYICPFNGPIK 60

Query: 61  GRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLR 120
           GRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLR
Sbjct: 61  GRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLR 120

Query: 121 FALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQGLPN 180
           FALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQGLPN
Sbjct: 121 FALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQGLPN 180

Query: 181 HHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIV 240
           HHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIV
Sbjct: 181 HHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIV 240

Query: 241 RCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDA 300
           RCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDA
Sbjct: 241 RCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDA 300

Query: 301 YHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQV 360
           YHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQV
Sbjct: 301 YHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQV 360

Query: 361 ADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFAS 420
           ADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFAS
Sbjct: 361 ADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFAS 420

Query: 421 RIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLF 480
           RIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLF
Sbjct: 421 RIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLF 480

Query: 481 NCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIR 540
           NCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIR
Sbjct: 481 NCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYIR 540

Query: 541 WNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQMMPHVQ 600
           WNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQMMPHVQ
Sbjct: 541 WNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPSQMMPHVQ 600

Query: 601 THF 603
           THF
Sbjct: 601 THF 603


>gi|44680154 myotubularin-related protein 2 isoform 1 [Homo sapiens]
          Length = 643

 Score =  800 bits (2067), Expect = 0.0
 Identities = 393/620 (63%), Positives = 480/620 (77%), Gaps = 22/620 (3%)

Query: 1   MASASTSKYNSHSLENESIK-------RTSRDGVNRDLT-----------EAVPRLPGET 42
           ++SASTS ++ +S+  +S          TS D  + DL            E  P LPGE 
Sbjct: 25  LSSASTS-HSENSVHTKSASVVSSDSISTSADNFSPDLRVLRESNKLAEMEEPPLLPGEN 83

Query: 43  LIT-DKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATS 101
           +    K+V YICPF G ++G + +TNYRLY +S+E D   +LD  LGVI+R+EK+GGA+S
Sbjct: 84  IKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVINRVEKIGGASS 143

Query: 102 RGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNV 161
           RGENSYGL+  CKD+RNLRFA K EG +RR +FE L +YAFP++++LPLFAF  +E F  
Sbjct: 144 RGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLFAFEYKEVFPE 203

Query: 162 DGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRS 221
           +GW +Y+P+ EYRRQG+PN  WRIT IN+ YELCDTYPALLVVP    D++L+RVA+FRS
Sbjct: 204 NGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDEELKRVASFRS 263

Query: 222 RNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARP 281
           R RIPVLSWIHPE++  I RCSQP+VG+SGKR+K+DEKYL  I ++N Q  K+ I+DARP
Sbjct: 264 RGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQSHKIFIFDARP 323

Query: 282 SVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSL 341
           SVNAVANKA GGGYES+DAY NAEL FLDIHNIHVMRESL+K+K+IVYPN+EE+HWLS+L
Sbjct: 324 SVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPNIEETHWLSNL 383

Query: 342 ESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIE 401
           ESTHWLEHIKL+L GA+++ADKV SGK+SV+VHCSDGWDRTAQLTSLAMLMLD +YR+I 
Sbjct: 384 ESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAMLMLDGYYRTIR 443

Query: 402 GFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQ 461
           GFE+LV+KEW+SFGH+F  R+GHGDKNH DADRSP+FLQFIDCVWQM++QFPTAFEFNE 
Sbjct: 444 GFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQFPTAFEFNEY 503

Query: 462 FLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRV 521
           FLI ILDHLYSC FGTFL N E  R ++ + +RTVSLWS INS  E F NP Y    N V
Sbjct: 504 FLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTNPLYGSYSNHV 563

Query: 522 LYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAK 581
           LYPVASMRHLELWV YYIRWNPR+K Q+  P+  RY ELLA R E  K++EELQ   S +
Sbjct: 564 LYPVASMRHLELWVGYYIRWNPRMKPQE--PIHNRYKELLAKRAELQKKVEELQREISNR 621

Query: 582 LSDPPTSPSSPSQMMPHVQT 601
            +      SSP+Q +  VQT
Sbjct: 622 STSSSERASSPAQCVTPVQT 641


>gi|41350318 myotubularin-related protein 2 isoform 2 [Homo sapiens]
          Length = 571

 Score =  798 bits (2062), Expect = 0.0
 Identities = 381/570 (66%), Positives = 460/570 (80%), Gaps = 3/570 (0%)

Query: 33  EAVPRLPGETLIT-DKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVIS 91
           E  P LPGE +    K+V YICPF G ++G + +TNYRLY +S+E D   +LD  LGVI+
Sbjct: 2   EEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVIN 61

Query: 92  RIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLF 151
           R+EK+GGA+SRGENSYGL+  CKD+RNLRFA K EG +RR +FE L +YAFP++++LPLF
Sbjct: 62  RVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLF 121

Query: 152 AFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDD 211
           AF  +E F  +GW +Y+P+ EYRRQG+PN  WRIT IN+ YELCDTYPALLVVP    D+
Sbjct: 122 AFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDE 181

Query: 212 DLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQI 271
           +L+RVA+FRSR RIPVLSWIHPE++  I RCSQP+VG+SGKR+K+DEKYL  I ++N Q 
Sbjct: 182 ELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQS 241

Query: 272 SKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPN 331
            K+ I+DARPSVNAVANKA GGGYES+DAY NAEL FLDIHNIHVMRESL+K+K+IVYPN
Sbjct: 242 HKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPN 301

Query: 332 VEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAML 391
           +EE+HWLS+LESTHWLEHIKL+L GA+++ADKV SGK+SV+VHCSDGWDRTAQLTSLAML
Sbjct: 302 IEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAML 361

Query: 392 MLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQ 451
           MLD +YR+I GFE+LV+KEW+SFGH+F  R+GHGDKNH DADRSP+FLQFIDCVWQM++Q
Sbjct: 362 MLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQ 421

Query: 452 FPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKN 511
           FPTAFEFNE FLI ILDHLYSC FGTFL N E  R ++ + +RTVSLWS INS  E F N
Sbjct: 422 FPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTN 481

Query: 512 PFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRL 571
           P Y    N VLYPVASMRHLELWV YYIRWNPR+K Q+  P+  RY ELLA R E  K++
Sbjct: 482 PLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQE--PIHNRYKELLAKRAELQKKV 539

Query: 572 EELQLANSAKLSDPPTSPSSPSQMMPHVQT 601
           EELQ   S + +      SSP+Q +  VQT
Sbjct: 540 EELQREISNRSTSSSERASSPAQCVTPVQT 569


>gi|41350316 myotubularin-related protein 2 isoform 2 [Homo sapiens]
          Length = 571

 Score =  798 bits (2062), Expect = 0.0
 Identities = 381/570 (66%), Positives = 460/570 (80%), Gaps = 3/570 (0%)

Query: 33  EAVPRLPGETLIT-DKEVIYICPFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVIS 91
           E  P LPGE +    K+V YICPF G ++G + +TNYRLY +S+E D   +LD  LGVI+
Sbjct: 2   EEPPLLPGENIKDMAKDVTYICPFTGAVRGTLTVTNYRLYFKSMERDPPFVLDASLGVIN 61

Query: 92  RIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLF 151
           R+EK+GGA+SRGENSYGL+  CKD+RNLRFA K EG +RR +FE L +YAFP++++LPLF
Sbjct: 62  RVEKIGGASSRGENSYGLETVCKDIRNLRFAHKPEGRTRRSIFENLMKYAFPVSNNLPLF 121

Query: 152 AFLNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDD 211
           AF  +E F  +GW +Y+P+ EYRRQG+PN  WRIT IN+ YELCDTYPALLVVP    D+
Sbjct: 122 AFEYKEVFPENGWKLYDPLLEYRRQGIPNESWRITKINERYELCDTYPALLVVPANIPDE 181

Query: 212 DLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQI 271
           +L+RVA+FRSR RIPVLSWIHPE++  I RCSQP+VG+SGKR+K+DEKYL  I ++N Q 
Sbjct: 182 ELKRVASFRSRGRIPVLSWIHPESQATITRCSQPMVGVSGKRSKEDEKYLQAIMDSNAQS 241

Query: 272 SKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPN 331
            K+ I+DARPSVNAVANKA GGGYES+DAY NAEL FLDIHNIHVMRESL+K+K+IVYPN
Sbjct: 242 HKIFIFDARPSVNAVANKAKGGGYESEDAYQNAELVFLDIHNIHVMRESLRKLKEIVYPN 301

Query: 332 VEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAML 391
           +EE+HWLS+LESTHWLEHIKL+L GA+++ADKV SGK+SV+VHCSDGWDRTAQLTSLAML
Sbjct: 302 IEETHWLSNLESTHWLEHIKLILAGALRIADKVESGKTSVVVHCSDGWDRTAQLTSLAML 361

Query: 392 MLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQ 451
           MLD +YR+I GFE+LV+KEW+SFGH+F  R+GHGDKNH DADRSP+FLQFIDCVWQM++Q
Sbjct: 362 MLDGYYRTIRGFEVLVEKEWLSFGHRFQLRVGHGDKNHADADRSPVFLQFIDCVWQMTRQ 421

Query: 452 FPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKN 511
           FPTAFEFNE FLI ILDHLYSC FGTFL N E  R ++ + +RTVSLWS INS  E F N
Sbjct: 422 FPTAFEFNEYFLITILDHLYSCLFGTFLCNSEQQRGKENLPKRTVSLWSYINSQLEDFTN 481

Query: 512 PFYTKEINRVLYPVASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRL 571
           P Y    N VLYPVASMRHLELWV YYIRWNPR+K Q+  P+  RY ELLA R E  K++
Sbjct: 482 PLYGSYSNHVLYPVASMRHLELWVGYYIRWNPRMKPQE--PIHNRYKELLAKRAELQKKV 539

Query: 572 EELQLANSAKLSDPPTSPSSPSQMMPHVQT 601
           EELQ   S + +      SSP+Q +  VQT
Sbjct: 540 EELQREISNRSTSSSERASSPAQCVTPVQT 569


>gi|28872761 myotubularin-related protein 1 [Homo sapiens]
          Length = 665

 Score =  728 bits (1878), Expect = 0.0
 Identities = 353/606 (58%), Positives = 454/606 (74%), Gaps = 8/606 (1%)

Query: 1   MASASTSKYNSHSLENESIKR---TSRDGVNRDLTEAVPRLPGETL-ITDKEVIYICPFN 56
           + +A+ S   S S+ +E++ R     RDG      E  P  PGE++    K+V+YICPF 
Sbjct: 61  LIAATISSQISGSVTSENVSRDYKALRDGNKLAQMEEAPLFPGESIKAIVKDVMYICPFM 120

Query: 57  GPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDM 116
           G + G + +T+++LY +++E D   ILDVPLGVISR+EK+G A S G+NS G++I CKDM
Sbjct: 121 GAVSGTLTVTDFKLYFKNVERDPHFILDVPLGVISRVEKIG-AQSHGDNSCGIEIVCKDM 179

Query: 117 RNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVEEYRRQ 176
           RNLR A KQE  S+  +FE L ++AFPL++   LFAF  +EKF ++GW VY+PV EY+RQ
Sbjct: 180 RNLRLAYKQEEQSKLGIFENLNKHAFPLSNGQALFAFSYKEKFPINGWKVYDPVSEYKRQ 239

Query: 177 GLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENK 236
           GLPN  W+I+ IN  YE CDTYPA++VVP    DDDL +VA FR++ R+PVLSWIHPE++
Sbjct: 240 GLPNESWKISKINSNYEFCDTYPAIIVVPTSVKDDDLSKVAAFRAKGRVPVLSWIHPESQ 299

Query: 237 TVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYE 296
             I RCSQPLVG + KR K+DEKYL  I + N Q  KL I+DAR +  A  NK  GGGYE
Sbjct: 300 ATITRCSQPLVGPNDKRCKEDEKYLQTIMDANAQSHKLIIFDARQNSVADTNKTKGGGYE 359

Query: 297 SDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTG 356
           S+ AY NAEL FL+IHNIHVMRESL+K+K+IVYP+++E+ WLS+++ THWLE+I+++L G
Sbjct: 360 SESAYPNAELVFLEIHNIHVMRESLRKLKEIVYPSIDEARWLSNVDGTHWLEYIRMLLAG 419

Query: 357 AIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGH 416
           A+++ADK+ SGK+SV+VHCSDGWDRTAQLTSLAMLMLDS+YR+I+GFE LV+KEWISFGH
Sbjct: 420 AVRIADKIESGKTSVVVHCSDGWDRTAQLTSLAMLMLDSYYRTIKGFETLVEKEWISFGH 479

Query: 417 KFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFG 476
           +FA R+GHG+ NH DADRSPIFLQF+DCVWQM++QFP+AFEFNE FLI ILDHLYSC FG
Sbjct: 480 RFALRVGHGNDNHADADRSPIFLQFVDCVWQMTRQFPSAFEFNELFLITILDHLYSCLFG 539

Query: 477 TFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVN 536
           TFL NCE  R ++ V  +T+SLWS INS  ++F NPF+    N VLYPVAS+ HLELWVN
Sbjct: 540 TFLCNCEQQRFKEDVYTKTISLWSYINSQLDEFSNPFFVNYENHVLYPVASLSHLELWVN 599

Query: 537 YYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLEELQLANSAK-LSDPPTSPSSPSQM 595
           YY+RWNPR++ Q   P+ Q   ELLA+R E  KR+E LQ   + + +S      SSPS  
Sbjct: 600 YYVRWNPRMRPQM--PIHQNLKELLAVRAELQKRVEGLQREVATRAVSSSSERGSSPSHS 657

Query: 596 MPHVQT 601
              V T
Sbjct: 658 ATSVHT 663


>gi|134142348 myotubularin related protein 6 [Homo sapiens]
          Length = 621

 Score =  360 bits (923), Expect = 3e-99
 Identities = 198/501 (39%), Positives = 298/501 (59%), Gaps = 19/501 (3%)

Query: 56  NGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKD 115
           N  + G +Y+T   L         + IL      I+ +EK+   TS       L I CK+
Sbjct: 22  NKSLTGTLYLTATHLLFIDSHQKETWILHHH---IASVEKLALTTS----GCPLVIQCKN 74

Query: 116 MRNLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFN----VDGWTVYNPVE 171
            R + F + +E     D++  L + +    +   L+AF    K N    + GW + +  E
Sbjct: 75  FRTVHFIVPRE-RDCHDIYNSLLQLSKQAKYE-DLYAFSYNPKQNDSERLQGWQLIDLAE 132

Query: 172 EYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWI 231
           EY+R G+PN HW+++  N+ Y++C+TYP  L VP  AS   +   + FRS+ R PVLS+ 
Sbjct: 133 EYKRMGVPNSHWQLSDANRDYKICETYPRELYVPRIASKPIIVGSSKFRSKGRFPVLSYY 192

Query: 232 HPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKAT 291
           H + +  I RCSQPL G S  R  +DE  L  I + N     + + D RP +NA+AN+A 
Sbjct: 193 HQDKEAAICRCSQPLSGFSA-RCLEDEHLLQAISKANPVNRYMYVMDTRPKLNAMANRAA 251

Query: 292 GGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIV-YPNVEESHWLSSLESTHWLEHI 350
           G GYE++D Y N    F+ I NIHVMR SL+K+ ++     +  + + S LES+ WL HI
Sbjct: 252 GKGYENEDNYSNIRFQFVGIENIHVMRSSLQKLLEVNGTKGLSVNDFYSGLESSGWLRHI 311

Query: 351 KLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKE 410
           K V+  AI +A  ++   +SVLVHCSDGWDRT+Q+ SL  L+LDS+YR+I+GF +L++K+
Sbjct: 312 KAVMDAAIFLAKAITVENASVLVHCSDGWDRTSQVCSLGSLLLDSYYRTIKGFMVLIEKD 371

Query: 411 WISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHL 470
           WISFGHKF+ R G  D +  +   SP+F QF++CVW +++QFP AFEF+E FL+ I +H+
Sbjct: 372 WISFGHKFSERCGQLDGDPKEV--SPVFTQFLECVWHLTEQFPQAFEFSEAFLLQIHEHI 429

Query: 471 YSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINR--VLYPVASM 528
           +SC+FG FL NC+  RE  K+ E+T SLW  +  +++K+ NP Y+ E +R  VL P    
Sbjct: 430 HSCQFGNFLGNCQKEREELKLKEKTYSLWPFLLEDQKKYLNPLYSSESHRFTVLEPNTVS 489

Query: 529 RHLELWVNYYIRWNPRIKQQQ 549
            + + W N Y +++  +  +Q
Sbjct: 490 FNFKFWRNMYHQFDRTLHPRQ 510


>gi|21361759 myotubularin related protein 8 [Homo sapiens]
          Length = 704

 Score =  358 bits (920), Expect = 6e-99
 Identities = 197/496 (39%), Positives = 285/496 (57%), Gaps = 11/496 (2%)

Query: 58  PIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMR 117
           P  G +Y+T   L        +     + L  I+ +EK+   TS G     L + CK+ R
Sbjct: 23  PANGILYLTATHLIYVEASGAARKETWIALHHIATVEKLP-ITSLG---CPLTLRCKNFR 78

Query: 118 NLRFALKQEGHSRRDMFEILTRYAFPLAHSLPLFAF--LNEEKFNVDGWTVYNPVEEYRR 175
              F L  +         +L      L   L  F++   + ++    GW + +P+ ++ R
Sbjct: 79  VAHFVLDSDLVCHEVYISLLKLSQPALPEDLYAFSYNPKSSKEMRESGWKLIDPISDFGR 138

Query: 176 QGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPEN 235
            G+PN +W IT  N+ YE+C TYP  +VVP   +   +   + FRS+ R+PVLS+++ EN
Sbjct: 139 MGIPNRNWTITDANRNYEICSTYPPEIVVPKSVTLGTVVGSSKFRSKERVPVLSYLYKEN 198

Query: 236 KTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGY 295
              I RCSQPL G    R  DDE  L+ I +TN     + + D RP +NA+AN+A G GY
Sbjct: 199 NAAICRCSQPLSGFY-TRCVDDELLLEAISQTNPGSQFMYVVDTRPKLNAMANRAAGKGY 257

Query: 296 ESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEE-SHWLSSLESTHWLEHIKLVL 354
           E++D Y N    F+ I NIHVMR SL+K+ ++        S +LS LES+ WL HIK ++
Sbjct: 258 ENEDNYANIRFRFMGIENIHVMRSSLQKLLEVCELKTPTMSEFLSGLESSGWLRHIKAIM 317

Query: 355 TGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISF 414
              I +   V   K+SVLVHCSDGWDRTAQ+ S+A ++LD FYR+ +G  IL++KEWIS 
Sbjct: 318 DAGIFITKAVKVEKASVLVHCSDGWDRTAQVCSVASILLDPFYRTFKGLMILIEKEWISM 377

Query: 415 GHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCR 474
           GHKF+ R GH D +  +   SPIF QF+DC+WQ+ +QFP AFEFNE FL+ I DH++SC+
Sbjct: 378 GHKFSQRCGHLDGDSKEV--SPIFTQFLDCIWQLMEQFPCAFEFNENFLLEIHDHVFSCQ 435

Query: 475 FGTFLFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTK-EINRVLYPVASMRHLEL 533
           FG FL NC+  RE  +V E+T S+W  +   K  F+NP Y    +  VL P     +++ 
Sbjct: 436 FGNFLGNCQKDREDLRVYEKTHSVWPFLVQRKPDFRNPLYKGFTMYGVLNPSTVPYNIQF 495

Query: 534 WVNYYIRWNPRIKQQQ 549
           W   Y R++  ++ +Q
Sbjct: 496 WCGMYNRFDKGLQPKQ 511


>gi|225543474 myotubularin related protein 7 [Homo sapiens]
          Length = 660

 Score =  346 bits (888), Expect = 3e-95
 Identities = 202/523 (38%), Positives = 306/523 (58%), Gaps = 30/523 (5%)

Query: 90  ISRIEKMGGATSRGENSYGLDITCKDMRNLRFALKQEGHSRRDMFEILTRYAFPLAHS-L 148
           IS IEK    T+ G     L I CK+ + ++  + QE     D++  L R A P+ +  L
Sbjct: 55  ISTIEKQA-TTATG---CPLLIRCKNFQIIQLIIPQE-RDCHDVYISLIRLARPVKYEEL 109

Query: 149 PLFAF--LNEEKFNVDGWTVYNPVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPY 206
             F+F  + +++    GW + +  EEY R GLPNH+W+++ +N+ Y +CD+YP  L VP 
Sbjct: 110 YCFSFNPMLDKEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPK 169

Query: 207 RASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRE 266
            A+   +   + FRSR R PVLS+ + +N   I R SQPL G S  R  +DE+ L  IR+
Sbjct: 170 SATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSA-RCLEDEQMLQAIRK 228

Query: 267 TNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKD 326
            N     + + D RP +NA+AN+A G GYE++D Y N +  F+ I NIHVMR SL+K+ +
Sbjct: 229 ANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLE 288

Query: 327 IVY---PNVEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTA 383
           +     P++ +  W   LE++ WL HIK ++   I +A  VS   +SVLVHCSDGWDRTA
Sbjct: 289 VCELKSPSMSDFLW--GLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTA 346

Query: 384 QLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFID 443
           Q+ S+A L+LD  YR+++GF +L++K+WISFGHKF  R G+ D +  +   SP+  QFI+
Sbjct: 347 QVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEI--SPVIDQFIE 404

Query: 444 CVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLIN 503
           CVWQ+ +QFP AFEFNE+FLI I  H+YSC+FG FL N +  R   K+ ERT SLW+ + 
Sbjct: 405 CVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLW 464

Query: 504 SNKEKFKNPFYTKEINR----VLYPVASMRHL-ELWVNYYIRWNPRIKQQQP-------- 550
            N+  + NP +  + ++    +  P      + + W   Y R+   ++ +Q         
Sbjct: 465 KNRADYLNPLFRADHSQTQGTLHLPTTPCNFMYKFWSGMYNRFEKGMQPRQSVTDYLMAV 524

Query: 551 NPVEQRYMELLALRDEYIKRLEELQLANSAKLSDPPTSPSSPS 593
               Q+  E L   +E +++++++QL N  K+    + PS  S
Sbjct: 525 KEETQQLEEELEALEERLEKIQKVQL-NCTKVKSKQSEPSKHS 566


>gi|23510389 myotubularin-related protein 3 isoform b [Homo sapiens]
          Length = 1161

 Score =  335 bits (858), Expect = 9e-92
 Identities = 197/541 (36%), Positives = 293/541 (54%), Gaps = 80/541 (14%)

Query: 63  VYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFA 122
           + ++NYRL+++  E+    +++VPL +I  +E          + + L +TCKD + +R  
Sbjct: 53  IALSNYRLHIKFKES----LVNVPLQLIESVEC--------RDIFQLHLTCKDCKVIRCQ 100

Query: 123 ----------LKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVE- 171
                     LK+  ++ R   +I   ++F   H+  +  + +E++ + D   +  P E 
Sbjct: 101 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAY-HAWCMEVYASEKEQHGD---LCRPGEH 156

Query: 172 -------EYRRQGLP-NHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRN 223
                  E  R G   N+ WRI+ IN+ Y+LC +YP  L+VP   +D +L  V++FRS  
Sbjct: 157 VTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWK 216

Query: 224 RIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVI-----------------RE 266
           RIP + + H  N  VI RC QP V   G RN DDE  +  +                 R 
Sbjct: 217 RIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRN 276

Query: 267 TNK----------------------------QISKLTIYDARPSVNAVANKATGGGYESD 298
           T++                            Q  KL I DAR    AVAN+A GGG E  
Sbjct: 277 TSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECP 336

Query: 299 DAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAI 358
           + Y N E+ F+ + NIH +R S + ++ +     +  +WLS+LEST WL H+ ++L  A+
Sbjct: 337 EYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSAL 396

Query: 359 QVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKF 418
            V   V   +  VLVHCSDGWDRT Q+ +LA L+LD +YR+IEGF++LV+ EW+ FGHKF
Sbjct: 397 LVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKF 456

Query: 419 ASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTF 478
           A R GHG+ +    +R P+FLQ++DCV Q+ +QFP +FEFNE FL+ ++ H YSC FGTF
Sbjct: 457 ADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTF 516

Query: 479 LFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYY 538
           L N    R  +   ERT S+WSL+ +  + FKN  Y+ +   VLYPV  +R+L LW   Y
Sbjct: 517 LCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVY 576

Query: 539 I 539
           +
Sbjct: 577 L 577


>gi|23510387 myotubularin-related protein 3 isoform a [Homo sapiens]
          Length = 1170

 Score =  335 bits (858), Expect = 9e-92
 Identities = 197/541 (36%), Positives = 293/541 (54%), Gaps = 80/541 (14%)

Query: 63  VYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFA 122
           + ++NYRL+++  E+    +++VPL +I  +E          + + L +TCKD + +R  
Sbjct: 53  IALSNYRLHIKFKES----LVNVPLQLIESVEC--------RDIFQLHLTCKDCKVIRCQ 100

Query: 123 ----------LKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVE- 171
                     LK+  ++ R   +I   ++F   H+  +  + +E++ + D   +  P E 
Sbjct: 101 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAY-HAWCMEVYASEKEQHGD---LCRPGEH 156

Query: 172 -------EYRRQGLP-NHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRN 223
                  E  R G   N+ WRI+ IN+ Y+LC +YP  L+VP   +D +L  V++FRS  
Sbjct: 157 VTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWK 216

Query: 224 RIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVI-----------------RE 266
           RIP + + H  N  VI RC QP V   G RN DDE  +  +                 R 
Sbjct: 217 RIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRN 276

Query: 267 TNK----------------------------QISKLTIYDARPSVNAVANKATGGGYESD 298
           T++                            Q  KL I DAR    AVAN+A GGG E  
Sbjct: 277 TSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECP 336

Query: 299 DAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAI 358
           + Y N E+ F+ + NIH +R S + ++ +     +  +WLS+LEST WL H+ ++L  A+
Sbjct: 337 EYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSAL 396

Query: 359 QVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKF 418
            V   V   +  VLVHCSDGWDRT Q+ +LA L+LD +YR+IEGF++LV+ EW+ FGHKF
Sbjct: 397 LVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKF 456

Query: 419 ASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTF 478
           A R GHG+ +    +R P+FLQ++DCV Q+ +QFP +FEFNE FL+ ++ H YSC FGTF
Sbjct: 457 ADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTF 516

Query: 479 LFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYY 538
           L N    R  +   ERT S+WSL+ +  + FKN  Y+ +   VLYPV  +R+L LW   Y
Sbjct: 517 LCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVY 576

Query: 539 I 539
           +
Sbjct: 577 L 577


>gi|10835109 myotubularin-related protein 3 isoform c [Homo sapiens]
          Length = 1198

 Score =  335 bits (858), Expect = 9e-92
 Identities = 197/541 (36%), Positives = 293/541 (54%), Gaps = 80/541 (14%)

Query: 63  VYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLRFA 122
           + ++NYRL+++  E+    +++VPL +I  +E          + + L +TCKD + +R  
Sbjct: 53  IALSNYRLHIKFKES----LVNVPLQLIESVEC--------RDIFQLHLTCKDCKVIRCQ 100

Query: 123 ----------LKQEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPVE- 171
                     LK+  ++ R   +I   ++F   H+  +  + +E++ + D   +  P E 
Sbjct: 101 FSTFEQCQEWLKRLNNAIRPPAKIEDLFSFAY-HAWCMEVYASEKEQHGD---LCRPGEH 156

Query: 172 -------EYRRQGLP-NHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRN 223
                  E  R G   N+ WRI+ IN+ Y+LC +YP  L+VP   +D +L  V++FRS  
Sbjct: 157 VTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWK 216

Query: 224 RIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVI-----------------RE 266
           RIP + + H  N  VI RC QP V   G RN DDE  +  +                 R 
Sbjct: 217 RIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACASDSRSSGSKLSTRN 276

Query: 267 TNK----------------------------QISKLTIYDARPSVNAVANKATGGGYESD 298
           T++                            Q  KL I DAR    AVAN+A GGG E  
Sbjct: 277 TSRDFPNGGDLSDVEFDSSLSNASGAESLAIQPQKLLILDARSYAAAVANRAKGGGCECP 336

Query: 299 DAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAI 358
           + Y N E+ F+ + NIH +R S + ++ +     +  +WLS+LEST WL H+ ++L  A+
Sbjct: 337 EYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSAL 396

Query: 359 QVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKF 418
            V   V   +  VLVHCSDGWDRT Q+ +LA L+LD +YR+IEGF++LV+ EW+ FGHKF
Sbjct: 397 LVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKF 456

Query: 419 ASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTF 478
           A R GHG+ +    +R P+FLQ++DCV Q+ +QFP +FEFNE FL+ ++ H YSC FGTF
Sbjct: 457 ADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTF 516

Query: 479 LFNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYY 538
           L N    R  +   ERT S+WSL+ +  + FKN  Y+ +   VLYPV  +R+L LW   Y
Sbjct: 517 LCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVY 576

Query: 539 I 539
           +
Sbjct: 577 L 577


>gi|217272865 myotubularin related protein 4 [Homo sapiens]
          Length = 1195

 Score =  327 bits (838), Expect = 2e-89
 Identities = 212/609 (34%), Positives = 311/609 (51%), Gaps = 94/609 (15%)

Query: 63  VYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYGLDITCKDMRNLR-- 120
           + I+NYRL+++  ++    +++VPL +I  +E          + + L I+CKD + +R  
Sbjct: 53  IAISNYRLHIKFKDS----VINVPLRMIDSVES--------RDMFQLHISCKDSKVVRCH 100

Query: 121 ---FALKQEGHSRRDMFEILTRYAFPLAHSLPLFAF--------LNEEKFNVDGWTVYNP 169
              F   QE  SR      L+R     A    LFAF        L EE  +     +  P
Sbjct: 101 FSTFKQCQEWLSR------LSRATARPAKPEDLFAFAYHAWCLGLTEEDQHTH---LCQP 151

Query: 170 VEEYR--------RQGLPNHH-WRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFR 220
            E  R        R G    + WR++ IN  Y+LC +YP  L+VP   +D +L  VA+FR
Sbjct: 152 GEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFR 211

Query: 221 SRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVI----------RETNKQ 270
           S  RIPV+ + H  N   I RCSQP +   G RN DDE  +  I          R T   
Sbjct: 212 SWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRATGGS 271

Query: 271 IS-------------------------------KLTIYDARPSVNAVANKATGGGYESDD 299
           +S                               KL I DAR    AVAN+A GGG E ++
Sbjct: 272 LSTGNNDTSEACDADFDSSLTACSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEE 331

Query: 300 AYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQ 359
            Y N E+ F+ + NIH +R S + ++ +     + S+WLS+LEST WL+H+ ++L  A+ 
Sbjct: 332 YYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVL 391

Query: 360 VADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFA 419
           VA+ V      VLVHCSDGWDRT Q+ +LA ++LD +YR++EGF++LV+ +W+ FGHKF 
Sbjct: 392 VANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFG 451

Query: 420 SRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFL 479
            R GH +      ++ P+FLQ++D V Q+ KQFP  FEFNE FL+ ++ H YSC +GTFL
Sbjct: 452 DRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFL 511

Query: 480 FNCESARERQKVTERTVSLWSLINSNKEKFKNPFYTKEINRVLYPVASMRHLELWVNYYI 539
            N    RE++ + +RT S+W+L+ +  + F N  YT   + VL+PV  +R L LW   Y+
Sbjct: 512 ANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYL 571

Query: 540 RWNPRIKQQQPNPVEQRYMELLALRDEYIKR-LEEL-------QLANSAKLSDPPTSPSS 591
             +      + N     Y+  +A   E+  R L+ L        L ++   S P T  SS
Sbjct: 572 PASSPCTLGEEN--MDLYLSPVAQSQEFSGRSLDRLPKTRSMDDLLSACDTSSPLTRTSS 629

Query: 592 PSQMMPHVQ 600
              +  H Q
Sbjct: 630 DPNLNNHCQ 638


>gi|19923424 myotubularin related protein 9 [Homo sapiens]
          Length = 549

 Score =  297 bits (761), Expect = 2e-80
 Identities = 184/528 (34%), Positives = 285/528 (53%), Gaps = 30/528 (5%)

Query: 54  PFNGPIKGRVYITNYRLYLRSLETDSSLILDVPLGVISRIEKMGGATSRGENSYG-LDIT 112
           PF   ++G + +T + L L S + D++  L +    I  I+K      R   S G + I 
Sbjct: 20  PFYPAVEGTLCLTGHHLILSSRQ-DNTEELWLLHSNIDAIDK------RFVGSLGTIIIK 72

Query: 113 CKDMRNLRFALK--QEGHSRRDMFEILTRYAFPLAHSLPLFAFLNEEKFNV--DGWTVYN 168
           CKD R ++  +   +E  +     E L+     L     ++ F     F V  DGW  + 
Sbjct: 73  CKDFRIIQLDIPGMEECLNIASSIEALST----LDSITLMYPFFYRPMFEVIEDGWHSFL 128

Query: 169 PVEEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVL 228
           P +E+         WR++++NK + +C +YP ++ VP    D+ LR+VATFR   R PVL
Sbjct: 129 PEQEFELYSSATSEWRLSYVNKEFAVCPSYPPIVTVPKSIDDEALRKVATFRHGGRFPVL 188

Query: 229 SWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVAN 288
           S+ H +N  VI+R  QPL G +G+R K+DEK ++      K   +  I D R    A   
Sbjct: 189 SYYHKKNGMVIMRSGQPLTGTNGRRCKEDEKLINATLRAGK---RGYIIDTRSLNVAQQT 245

Query: 289 KATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEE-SHWLSSLESTHWL 347
           +A GGG+E +  Y         I   H+++ESL K+ +           WLS LE+++WL
Sbjct: 246 RAKGGGFEQEAHYPQWRRIHKSIERYHILQESLIKLVEACNDQTHNMDRWLSKLEASNWL 305

Query: 348 EHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILV 407
            HIK +LT A   A  +    +S+L+H ++G D T Q+TSLA ++L+   R+I GFE L+
Sbjct: 306 THIKEILTTACLAAQCIDREGASILIHGTEGTDSTLQVTSLAQIILEPRSRTIRGFEALI 365

Query: 408 QKEWISFGHKFASRIGHGDKNHTDAD-RSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIII 466
           ++EW+  GH F  R       +T     +P+FL F+DCVWQ+ +QFP +FEFNE FLI++
Sbjct: 366 EREWLQAGHPFQQRCAQSAYCNTKQKWEAPVFLLFLDCVWQILRQFPCSFEFNENFLIML 425

Query: 467 LDHLYSCRFGTFLFNCESARERQKVTERTVSLWSLINSNKE--KFKNPFYTKEINRVLYP 524
            +H Y+ +FGTFL N ES R + K+ ++T+SLWS +N   E  KF NP +    N V++P
Sbjct: 426 FEHAYASQFGTFLGNNESERCKLKLQQKTMSLWSWVNQPSELSKFTNPLFEAN-NLVIWP 484

Query: 525 VASMRHLELWVNYYIRWNPRIKQQQPNPVEQRYMELLALRDEYIKRLE 572
             + + L LW   ++RWN   K      +++ Y E++ +  EY K L+
Sbjct: 485 SVAPQSLPLWEGIFLRWNRSSKY-----LDEAYEEMVNI-IEYNKELQ 526


>gi|124028527 myotubularin related protein 10 [Homo sapiens]
          Length = 777

 Score =  154 bits (390), Expect = 2e-37
 Identities = 151/562 (26%), Positives = 245/562 (43%), Gaps = 128/562 (22%)

Query: 38  LPGETLITDKEVIYICPFNGPIK----GRVYITNYRLYLRSLETDSSLIL---------- 83
           LPGE ++ +   +  C      +    G++  +N+++   S  TD  + L          
Sbjct: 39  LPGEIVVNEVNFVRKCIATDTSQYDLWGKLICSNFKI---SFITDDPMPLQKFHYRNLLL 95

Query: 84  ---DVPLGVISRI---------EKMGGATSRGE-NSYGLDITCKDMRNLRFALKQEG-HS 129
              DVPL  I +I         +K+ G   + + N   L I CKD R +RF   + G  S
Sbjct: 96  GEHDVPLTCIEQIVTVNDHKRKQKVLGPNQKLKFNPTELIIYCKDFRIVRFRFDESGPES 155

Query: 130 RRDMFEILTRYAFPLAHSLPLFAFLNEEKFNVDGWTVYNPV------------------- 170
            + +   +  Y+ P    L LFAF    K   +     N +                   
Sbjct: 156 AKKVCLAIAHYSQPTDLQL-LFAFEYVGKKYHNSANKINGIPSGDGGGGGGGGNGAGGGS 214

Query: 171 --------------EEYRRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRRV 216
                          E +R G     WR+  IN+ Y +    P  +VVP   +D DL+  
Sbjct: 215 SQKTPLFETYSDWDREIKRTGASG--WRVCSINEGYMISTCLPEYIVVPSSLADQDLKIF 272

Query: 217 ATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTI 276
           +      R+P+  W H  N + +VR +  L+    ++ K D++  + I +++ Q S +  
Sbjct: 273 SHSFVGRRMPLWCWSH-SNGSALVRMA--LIKDVLQQRKIDQRICNAITKSHPQRSDV-- 327

Query: 277 YDARPSVNAVANKATGGGYESDDAYHNAELFFLD--IHNIHVMRESLKKVKDIVY--PNV 332
                             Y+SD          LD  + NI  ++ +  K+K +    P  
Sbjct: 328 ------------------YKSD----------LDKTLPNIQEVQAAFVKLKQLCVNEPFE 359

Query: 333 E-ESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAML 391
           E E  WLSSLE+T WLE+++  L  + ++   + S   SV++   +G D +  + SL  +
Sbjct: 360 ETEEKWLSSLENTRWLEYVRAFLKHSAELVYMLESKHLSVVLQEEEGRDLSCCVASLVQV 419

Query: 392 MLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQ 451
           MLD ++R+I GF+ L+QKEW+  G++F  R  H  ++  +   SP+FL F+D  WQ+ +Q
Sbjct: 420 MLDPYFRTITGFQSLIQKEWVMAGYQFLDRCNHLKRSEKE---SPLFLLFLDATWQLLEQ 476

Query: 452 FPTAFEFNEQFLIIILDHLYSCRFGTFLFNCESARERQKVTERTVSL------------- 498
           +P AFEF+E +L ++ D      FGTFLFN    R +Q  TE  +S              
Sbjct: 477 YPAAFEFSETYLAVLYDSTRISLFGTFLFNSPHQRVKQS-TEFAISKNIQLGDEKGLKFP 535

Query: 499 ----WSLINSNKEK--FKNPFY 514
               WSL  + K++  F NPFY
Sbjct: 536 SVWDWSLQFTAKDRTLFHNPFY 557



 Score = 31.2 bits (69), Expect = 2.9
 Identities = 15/43 (34%), Positives = 24/43 (55%), Gaps = 2/43 (4%)

Query: 503 NSNKEKFKNPFYTKEINR--VLYPVASMRHLELWVNYYIRWNP 543
           NS+ E++   +++K  N   V+ P  S  H++LW   Y RW P
Sbjct: 624 NSDTEQYFREWFSKPANLHGVILPRVSGTHIKLWKLCYFRWVP 666


>gi|29788755 SET binding factor 2 [Homo sapiens]
          Length = 1849

 Score =  145 bits (367), Expect = 8e-35
 Identities = 89/253 (35%), Positives = 139/253 (54%), Gaps = 19/253 (7%)

Query: 303  NAELFFLDIHNIHVMRESLKKVKDIVYPNV----EESHWLSSLESTHWLEHIKLVLTGAI 358
            N E   ++ H I  ++ S KK+     P+      E  +L +L  + W   +  ++  A+
Sbjct: 1335 NCEFVPVEFHEIRQVKASFKKLMRACIPSTIPTDSEVTFLKALGDSEWFPQLHRIMQLAV 1394

Query: 359  QVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKF 418
             V++ + +G SSVLV   +GWD TAQ+TSL  L+ D FYR++EGF++LV+KEW+SFGHKF
Sbjct: 1395 VVSEVLENG-SSVLVCLEEGWDITAQVTSLVQLLSDPFYRTLEGFQMLVEKEWLSFGHKF 1453

Query: 419  ASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTF 478
            + R      N   +  +P+FLQF+DCV Q+  Q+PT FEFN  +L  +  H  S RF TF
Sbjct: 1454 SQR-SSLTLNCQGSGFAPVFLQFLDCVHQVHNQYPTEFEFNLYYLKFLAFHYVSNRFKTF 1512

Query: 479  LFNCESAR---------ERQKVTERTVSLWSLINSNKEK---FKNPFYTKEINRVLYPVA 526
            L + +  R         + +K  ++ V +W  I+   ++   F N  Y+      L P  
Sbjct: 1513 LLDSDYERLEHGTLFDDKGEKHAKKGVCIWECIDRMHKRSPIFFNYLYSPLEIEALKPNV 1572

Query: 527  SMRHLELWVNYYI 539
            ++  L+ W +YYI
Sbjct: 1573 NVSSLKKW-DYYI 1584



 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 26/60 (43%), Positives = 37/60 (61%)

Query: 182  HWRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVR 241
            ++RIT  N+ Y LC +YP LLVVP    D  L RVA     NR+PV+ W +  + T+++R
Sbjct: 1137 YFRITASNRMYSLCRSYPGLLVVPQAVQDSSLPRVARCYRHNRLPVVCWKNSRSGTLLLR 1196


>gi|239735519 SET binding factor 1 [Homo sapiens]
          Length = 1893

 Score =  141 bits (356), Expect = 2e-33
 Identities = 95/278 (34%), Positives = 145/278 (52%), Gaps = 25/278 (8%)

Query: 280  RPSVNAVANKATGGGYESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESH--- 336
            R ++  + +KA   G  SD      EL  +++     ++ S KK+     P    +    
Sbjct: 1349 RAALYILGDKAQLKGVRSDPL-QQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSP 1407

Query: 337  --WLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLD 394
              +L SLE + WL  I  +L  ++ V + + SG SSVLV   DGWD T Q+ SL  L+ D
Sbjct: 1408 ASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDITTQVVSLVQLLSD 1466

Query: 395  SFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQFPT 454
             FYR++EGF +LV+KEW+SFGH+F+ R  H     + +  +P+FLQF+DCV Q+  QFP 
Sbjct: 1467 PFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQS-SGFTPVFLQFLDCVHQVHLQFPM 1525

Query: 455  AFEFNEQFLIIILDHLYSCRFGTFLFNC------------ESARERQKVTERTVSLWSLI 502
             FEF++ +L  +  H  S RF TFL +             E    R +V  R  S+W  +
Sbjct: 1526 EFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCR--SVWEYV 1583

Query: 503  NSNKEK---FKNPFYTKEINRVLYPVASMRHLELWVNY 537
            +   ++   F N  Y  E   VL P +++ +L++W  Y
Sbjct: 1584 DRLSKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWDFY 1621



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 26/70 (37%), Positives = 42/70 (60%), Gaps = 4/70 (5%)

Query: 183  WRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRC 242
            +RI+ +N+ Y +C +YP LL+VP    D+ L+RV+    +NR PV+ W    +K V++R 
Sbjct: 1150 FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS 1209

Query: 243  SQPLVGMSGK 252
                 G+ GK
Sbjct: 1210 G----GLHGK 1215


>gi|94721263 myotubularin related protein 12 [Homo sapiens]
          Length = 747

 Score =  135 bits (341), Expect = 8e-32
 Identities = 120/439 (27%), Positives = 198/439 (45%), Gaps = 63/439 (14%)

Query: 109 LDITCKDMRNLRFALK--QEGHSRRDMFEILTRYAFP-LAHSLPLFAFLNEEKFNV---- 161
           L I CKD+R  +F L+  +E   +R +  I+     P L   L LF++    + N     
Sbjct: 139 LIIHCKDLRVFQFCLRYTKEEEVKRIVSGIIHHTQAPKLLKRLFLFSYATAAQNNTVTDP 198

Query: 162 -DGWTVYNPVEEY-----RRQGLPNHHWRITFINKCYELCDTYPALLVVPYRASDDDLRR 215
            +   +++ ++++     R +G  N  ++   +N+ Y++C+  PA  VVP    +++++R
Sbjct: 199 KNHTVMFDTLKDWCWELERTKG--NMKYKAVSVNEGYKVCERLPAYFVVPTPLPEENVQR 256

Query: 216 VATFRSRNRIPVLSWIHPENKTVIVRCSQPLVGMSGKRNKDDEKYLDVIRETNKQISKLT 275
                  + IP+  W               L+ MS    + D+  L + +     I K T
Sbjct: 257 F----QGHGIPIWCWSCHNGSA--------LLKMSALPKEQDDGILQIQKSFLDGIYK-T 303

Query: 276 IYDARPSVNAVANKATGGGY----ESDDAYHNAELFFLDIHNIHVMRESLKKVKDIVYPN 331
           I+  RP    V  +     +    E   AY   +  FL  ++       +K         
Sbjct: 304 IH--RPPYEIVKTEDLSSNFLSLQEIQTAYSKFKQLFLIDNSTEFWDTDIK--------- 352

Query: 332 VEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAML 391
                W S LES+ WL+ I+  L  AI++ + + +   +VL+   +  D    ++SL  L
Sbjct: 353 -----WFSLLESSSWLDIIRRCLKKAIEITECMEAQNMNVLLLEENASDLCCLISSLVQL 407

Query: 392 MLDSFYRSIEGFEILVQKEWISFGHKFASRIGHGDKNHTDADRSPIFLQFIDCVWQMSKQ 451
           M+D   R+  GF+ L+QKEW+  GH F  R  H  +N  D +  P+FL F+DCVWQ+  Q
Sbjct: 408 MMDPHCRTRIGFQSLIQKEWVMGGHCFLDRCNHLRQN--DKEEVPVFLLFLDCVWQLVHQ 465

Query: 452 FPTAFEFNEQFLIIILDHLYSCRFGTFLFN------CESARERQKVTERTVSL-----WS 500
            P AFEF E +L ++ D LY   F TF FN          RE Q    + ++L     WS
Sbjct: 466 HPPAFEFTETYLTVLSDSLYIPIFSTFFFNSPHQKDTNMGREGQDTQSKPLNLLTVWDWS 525

Query: 501 LINSNKEK--FKNPFYTKE 517
           +    K +   KNP Y ++
Sbjct: 526 VQFEPKAQTLLKNPLYVEK 544


>gi|224994251 myotubularin related protein 11 isoform a [Homo
           sapiens]
          Length = 709

 Score =  127 bits (320), Expect = 2e-29
 Identities = 87/307 (28%), Positives = 150/307 (48%), Gaps = 35/307 (11%)

Query: 183 WRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRC 242
           WR++ +N+ +++  + P    VP R  D ++RR      + R P LSW HP    ++ RC
Sbjct: 214 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLL-RC 272

Query: 243 SQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYH 302
                  +   NK+D + ++++ +     S + + D    + ++A               
Sbjct: 273 GGFYT--ASDPNKEDIRAVELMLQAGH--SDVVLVDTMDELPSLA--------------- 313

Query: 303 NAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVAD 362
                  D+   H+   +L     +   +V E  WLS+LE T WL++++  L  A  ++ 
Sbjct: 314 -------DVQLAHLRLRALC----LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISV 362

Query: 363 KVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRI 422
            V+S   SV++      D    L+SL  L+     R++ GF+ LVQ+EW++ GH F +R+
Sbjct: 363 LVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRL 422

Query: 423 GHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNC 482
           G        ++ +P+FL F+DCVWQ+ +QFP  FEF+E FL+ + D +      TFL N 
Sbjct: 423 G----GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNT 478

Query: 483 ESARERQ 489
              R +Q
Sbjct: 479 PWERGKQ 485


>gi|89111941 myotubularin related protein 11 isoform b [Homo
           sapiens]
          Length = 640

 Score =  127 bits (320), Expect = 2e-29
 Identities = 87/307 (28%), Positives = 150/307 (48%), Gaps = 35/307 (11%)

Query: 183 WRITFINKCYELCDTYPALLVVPYRASDDDLRRVATFRSRNRIPVLSWIHPENKTVIVRC 242
           WR++ +N+ +++  + P    VP R  D ++RR      + R P LSW HP    ++ RC
Sbjct: 142 WRVSTVNERFDVATSLPRYFWVPNRILDSEVRRAFGHFHQGRGPRLSWHHPGGSDLL-RC 200

Query: 243 SQPLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYH 302
                  +   NK+D + ++++ +     S + + D    + ++A               
Sbjct: 201 GGFYT--ASDPNKEDIRAVELMLQAGH--SDVVLVDTMDELPSLA--------------- 241

Query: 303 NAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSSLESTHWLEHIKLVLTGAIQVAD 362
                  D+   H+   +L     +   +V E  WLS+LE T WL++++  L  A  ++ 
Sbjct: 242 -------DVQLAHLRLRALC----LPDSSVAEDKWLSALEGTRWLDYVRACLRKASDISV 290

Query: 363 KVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWISFGHKFASRI 422
            V+S   SV++      D    L+SL  L+     R++ GF+ LVQ+EW++ GH F +R+
Sbjct: 291 LVTSRVRSVILQERGDRDLNGLLSSLVQLLSAPEARTLFGFQSLVQREWVAAGHPFLTRL 350

Query: 423 GHGDKNHTDADRSPIFLQFIDCVWQMSKQFPTAFEFNEQFLIIILDHLYSCRFGTFLFNC 482
           G        ++ +P+FL F+DCVWQ+ +QFP  FEF+E FL+ + D +      TFL N 
Sbjct: 351 G----GTGASEEAPVFLLFLDCVWQLLQQFPADFEFSEFFLLALHDSVRVPDTLTFLRNT 406

Query: 483 ESARERQ 489
              R +Q
Sbjct: 407 PWERGKQ 413


>gi|117938274 jumpy isoform 3 [Homo sapiens]
          Length = 538

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 6/69 (8%)

Query: 365 SSGKSSVLVHCSDGWDRTAQLTSLAMLML---DSFYRSIEGFEIL---VQKEWISFGHKF 418
           S   S +LVHC  GWDRT    SL  L L      + S++  EIL   V  +W  FGH  
Sbjct: 320 SDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHML 379

Query: 419 ASRIGHGDK 427
             R+  G++
Sbjct: 380 VDRLSKGEE 388


>gi|117938272 jumpy isoform 1 [Homo sapiens]
          Length = 598

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 6/69 (8%)

Query: 365 SSGKSSVLVHCSDGWDRTAQLTSLAMLML---DSFYRSIEGFEIL---VQKEWISFGHKF 418
           S   S +LVHC  GWDRT    SL  L L      + S++  EIL   V  +W  FGH  
Sbjct: 320 SDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHML 379

Query: 419 ASRIGHGDK 427
             R+  G++
Sbjct: 380 VDRLSKGEE 388


>gi|117938270 jumpy isoform 2 [Homo sapiens]
          Length = 650

 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 26/69 (37%), Positives = 34/69 (49%), Gaps = 6/69 (8%)

Query: 365 SSGKSSVLVHCSDGWDRTAQLTSLAMLML---DSFYRSIEGFEIL---VQKEWISFGHKF 418
           S   S +LVHC  GWDRT    SL  L L      + S++  EIL   V  +W  FGH  
Sbjct: 320 SDDDSGLLVHCISGWDRTPLFISLLRLSLWADGLIHTSLKPTEILYLTVAYDWFLFGHML 379

Query: 419 ASRIGHGDK 427
             R+  G++
Sbjct: 380 VDRLSKGEE 388


>gi|4503417 dual specificity phosphatase 4 isoform 1 [Homo sapiens]
          Length = 394

 Score = 36.6 bits (83), Expect = 0.068
 Identities = 38/116 (32%), Positives = 49/116 (42%), Gaps = 10/116 (8%)

Query: 300 AYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSS---LESTHWLEHIKLVLTG 356
           AYH A    LD   I  +   L    D   PN  E H+      +E  H  + I      
Sbjct: 208 AYHAARRDMLDALGITAL---LNVSSDC--PNHFEGHYQYKCIPVEDNHKAD-ISSWFME 261

Query: 357 AIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWI 412
           AI+  D V   +  VLVHC  G  R+A +  LA LM+    R  E FE + Q+  I
Sbjct: 262 AIEYIDAVKDCRGRVLVHCQAGISRSATI-CLAYLMMKKRVRLEEAFEFVKQRRSI 316


>gi|16950652 dual specificity phosphatase 4 isoform 2 [Homo sapiens]
          Length = 303

 Score = 36.6 bits (83), Expect = 0.068
 Identities = 38/116 (32%), Positives = 49/116 (42%), Gaps = 10/116 (8%)

Query: 300 AYHNAELFFLDIHNIHVMRESLKKVKDIVYPNVEESHWLSS---LESTHWLEHIKLVLTG 356
           AYH A    LD   I  +   L    D   PN  E H+      +E  H  + I      
Sbjct: 117 AYHAARRDMLDALGITAL---LNVSSDC--PNHFEGHYQYKCIPVEDNHKAD-ISSWFME 170

Query: 357 AIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKEWI 412
           AI+  D V   +  VLVHC  G  R+A +  LA LM+    R  E FE + Q+  I
Sbjct: 171 AIEYIDAVKDCRGRVLVHCQAGISRSATI-CLAYLMMKKRVRLEEAFEFVKQRRSI 225


>gi|238231453 dual specificity phosphatase 7 [Homo sapiens]
          Length = 419

 Score = 34.3 bits (77), Expect = 0.34
 Identities = 19/50 (38%), Positives = 26/50 (52%), Gaps = 1/50 (2%)

Query: 343 STHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLM 392
           S HW +++      AI   D+  S K  VLVHC  G  R+  +T +A LM
Sbjct: 299 SDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVT-VAYLM 347


>gi|42764683 dual specificity phosphatase 6 isoform a [Homo sapiens]
          Length = 381

 Score = 33.5 bits (75), Expect = 0.58
 Identities = 40/179 (22%), Positives = 71/179 (39%), Gaps = 27/179 (15%)

Query: 245 PLVGMSGKRNKDDEKYLDVIRETNKQISKLTIYDARPSVNAVANKATGGGYESDDAYHNA 304
           P++G+ G R   D    D+  + ++  +  T  D  P  N            S  ++   
Sbjct: 163 PVLGLGGLRISSDSSS-DIESDLDRDPNSATDSDGSPLSN------------SQPSFPVE 209

Query: 305 ELFFL------DIHNIHVMRE-SLKKVKDI------VYPNVEESHWLSSLESTHWLEHIK 351
            L FL      D  N+ V+ E  +K + ++      ++ N  E  +     S HW +++ 
Sbjct: 210 ILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLS 269

Query: 352 LVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEGFEILVQKE 410
                AI   D+       VLVHC  G  R+  +T +A LM        + ++I+  K+
Sbjct: 270 QFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVT-VAYLMQKLNLSMNDAYDIVKMKK 327


>gi|4503421 dual specificity phosphatase 9 [Homo sapiens]
          Length = 384

 Score = 33.5 bits (75), Expect = 0.58
 Identities = 19/68 (27%), Positives = 34/68 (50%), Gaps = 1/68 (1%)

Query: 343 STHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAMLMLDSFYRSIEG 402
           S HW +++      AI+  D+  S    VLVHC  G  R+  +T +A LM        + 
Sbjct: 258 SDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVT-VAYLMQKLHLSLNDA 316

Query: 403 FEILVQKE 410
           ++++ +K+
Sbjct: 317 YDLVKRKK 324


>gi|148728162 protein tyrosine phosphatase, receptor type, J isoform 1
            precursor [Homo sapiens]
          Length = 1337

 Score = 33.1 bits (74), Expect = 0.75
 Identities = 24/78 (30%), Positives = 36/78 (46%), Gaps = 9/78 (11%)

Query: 324  VKDIVYPNVE--ESHWLSSLESTHWLEH-----IKLVLTGAIQVAD--KVSSGKSSVLVH 374
            ++D    N++  ESH L     T W +H       L++     V D  K S  +S +LVH
Sbjct: 1179 IRDFTVKNIQTSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLVRDYMKQSPPESPILVH 1238

Query: 375  CSDGWDRTAQLTSLAMLM 392
            CS G  RT    ++  L+
Sbjct: 1239 CSAGVGRTGTFIAIDRLI 1256


>gi|38261971 cyclic AMP-regulated phosphoprotein, 21 kD isoform 1
           [Homo sapiens]
          Length = 812

 Score = 32.0 bits (71), Expect = 1.7
 Identities = 18/62 (29%), Positives = 33/62 (53%), Gaps = 11/62 (17%)

Query: 547 QQQPNPVEQRYME---------LLALRDEYIKRLEELQLA--NSAKLSDPPTSPSSPSQM 595
           QQQP+P  Q+ ++         L+  RD+   +  ++ L+  +S +  +PP+ P  PS +
Sbjct: 523 QQQPSPQPQQQVQPPQPQMAGPLVTQRDDVATQFGQMTLSRQSSGETPEPPSGPVYPSSL 582

Query: 596 MP 597
           MP
Sbjct: 583 MP 584


>gi|38372911 dual specificity phosphatase 16 [Homo sapiens]
          Length = 665

 Score = 31.6 bits (70), Expect = 2.2
 Identities = 22/76 (28%), Positives = 37/76 (48%), Gaps = 7/76 (9%)

Query: 332 VEESHWLSSLESTHWLEHIKLVLTGAIQVADKVSSGKSSVLVHCSDGWDRTAQLTSLAML 391
           + ESH+L    +  + E I   L  ++   +K  +    VLVHC  G  R+A + ++A +
Sbjct: 201 IPESHFLRVPVNDSFCEKILPWLDKSVDFIEKAKASNGCVLVHCLAGISRSATI-AIAYI 259

Query: 392 M------LDSFYRSIE 401
           M      LD  YR ++
Sbjct: 260 MKRMDMSLDEAYRFVK 275


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.410 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,514,801
Number of Sequences: 37866
Number of extensions: 967141
Number of successful extensions: 2659
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 10
Number of HSP's that attempted gapping in prelim test: 2590
Number of HSP's gapped (non-prelim): 47
length of query: 603
length of database: 18,247,518
effective HSP length: 108
effective length of query: 495
effective length of database: 14,157,990
effective search space: 7008205050
effective search space used: 7008205050
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.