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Search of human proteins with 13173471
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
(454 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap... 947 0.0
gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo sap... 656 0.0
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa... 333 2e-91
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa... 333 2e-91
gi|116256363 transmembrane protease, serine 13 [Homo sapiens] 278 6e-75
gi|170932492 transmembrane protease, serine 5 [Homo sapiens] 270 3e-72
gi|33695155 hepsin [Homo sapiens] 249 3e-66
gi|4504481 hepsin [Homo sapiens] 249 3e-66
gi|223942069 enterokinase precursor [Homo sapiens] 246 3e-65
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap... 243 2e-64
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa... 239 4e-63
gi|4758508 transmembrane protease, serine 11D [Homo sapiens] 210 2e-54
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens] 209 5e-54
gi|187761337 transmembrane protease, serine 11B [Homo sapiens] 202 5e-52
gi|205360905 testis-specific serine protease 1 [Homo sapiens] 197 1e-50
gi|194018492 transmembrane protease, serine 11F [Homo sapiens] 195 8e-50
gi|148613878 acrosin precursor [Homo sapiens] 194 2e-49
gi|29244926 corin [Homo sapiens] 193 2e-49
gi|40254871 transmembrane protease, serine 11E [Homo sapiens] 193 2e-49
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens] 193 2e-49
gi|222831592 transmembrane protease, serine 7 [Homo sapiens] 193 3e-49
gi|4505881 plasminogen [Homo sapiens] 192 4e-49
gi|21614531 testisin isoform 2 [Homo sapiens] 192 4e-49
gi|5803197 testisin isoform 1 [Homo sapiens] 192 7e-49
gi|33667063 transmembrane protease, serine 9 [Homo sapiens] 191 1e-48
gi|11415040 matriptase [Homo sapiens] 190 3e-48
gi|4503627 coagulation factor XI precursor [Homo sapiens] 190 3e-48
gi|23957702 transmembrane protease, serine 6 [Homo sapiens] 189 3e-48
gi|58218970 protease, serine, 36 [Homo sapiens] 189 6e-48
gi|4506153 prostasin preproprotein [Homo sapiens] 188 8e-48
>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
sapiens]
Length = 454
Score = 947 bits (2447), Expect = 0.0
Identities = 454/454 (100%), Positives = 454/454 (100%)
Query: 1 MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI 60
MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI
Sbjct: 1 MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI 60
Query: 61 LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF 120
LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF
Sbjct: 61 LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF 120
Query: 121 TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK 180
TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK
Sbjct: 121 TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK 180
Query: 181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH 240
VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH
Sbjct: 181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH 240
Query: 241 LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR 300
LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR
Sbjct: 241 LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR 300
Query: 301 LGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHA 360
LGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHA
Sbjct: 301 LGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHA 360
Query: 361 AVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATS 420
AVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATS
Sbjct: 361 AVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATS 420
Query: 421 FGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 454
FGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
Sbjct: 421 FGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 454
>gi|14602457 transmembrane protease, serine 3 isoform 3 [Homo
sapiens]
Length = 344
Score = 656 bits (1693), Expect = 0.0
Identities = 318/324 (98%), Positives = 319/324 (98%)
Query: 1 MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI 60
MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI
Sbjct: 1 MGENDPPAVEAPFSFRSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIALI 60
Query: 61 LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF 120
LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF
Sbjct: 61 LALAIGLGIHFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF 120
Query: 121 TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK 180
TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK
Sbjct: 121 TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDK 180
Query: 181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH 240
VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH
Sbjct: 181 VTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYH 240
Query: 241 LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR 300
LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR
Sbjct: 241 LCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKR 300
Query: 301 LGNDIALMKLAGPLTFNEMIQPVC 324
LGNDIALMKLAGPLTFN +C
Sbjct: 301 LGNDIALMKLAGPLTFNGTSGSLC 324
>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
sapiens]
Length = 529
Score = 333 bits (854), Expect = 2e-91
Identities = 189/412 (45%), Positives = 242/412 (58%), Gaps = 21/412 (5%)
Query: 52 IVIGIIALILALAIGLGIHF---DCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
+ +G + ALA GL F CS C SS CI CDGVS C GEDE RC
Sbjct: 126 LTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 185
Query: 108 VRVGGQNAVLQVFTAA--SWKTMCSDDWKGHYANVACAQLGFPS-YVSSDNLRVSSLEGQ 164
VR+ G N +LQV+++ SW +C DDW +Y AC +G+ + + SS + S
Sbjct: 186 VRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTS 245
Query: 165 FREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYS--SRIVGGNM 222
F + S ++ D L+HS + C+S VV+L+C ACG S SRIVGG
Sbjct: 246 FMKLNTSAGNV---DIYKKLYHS----DACSSKAVVSLRCIACGVNLNSSRQSRIVGGES 298
Query: 223 SLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD-LYLPKSWTIQVGLV--SLLD 279
+L WPWQ SL Q H+CGGS+ITP WI+TAAHCV L P WT G++ S +
Sbjct: 299 ALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMF 358
Query: 280 NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCW 339
A + VEK++ H Y K NDIALMKL PLTFN++++PVCLPN ++CW
Sbjct: 359 YGA-GYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCW 417
Query: 340 TSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQG 399
SGWGATE+ G S VLN A V LI + CN R VY +I+P+M+CAG+L G VDSCQG
Sbjct: 418 ISGWGATEE-KGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG 476
Query: 400 DSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERD 451
DSGGPLV + +W L+G TS+G GCA+ +PGVY V F DWI+ QM D
Sbjct: 477 DSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRAD 528
>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
sapiens]
Length = 492
Score = 333 bits (854), Expect = 2e-91
Identities = 189/412 (45%), Positives = 242/412 (58%), Gaps = 21/412 (5%)
Query: 52 IVIGIIALILALAIGLGIHF---DCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
+ +G + ALA GL F CS C SS CI CDGVS C GEDE RC
Sbjct: 89 LTLGTFLVGAALAAGLLWKFMGSKCSNSGIECDSSGTCINPSNWCDGVSHCPGGEDENRC 148
Query: 108 VRVGGQNAVLQVFTAA--SWKTMCSDDWKGHYANVACAQLGFPS-YVSSDNLRVSSLEGQ 164
VR+ G N +LQV+++ SW +C DDW +Y AC +G+ + + SS + S
Sbjct: 149 VRLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTS 208
Query: 165 FREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYS--SRIVGGNM 222
F + S ++ D L+HS + C+S VV+L+C ACG S SRIVGG
Sbjct: 209 FMKLNTSAGNV---DIYKKLYHS----DACSSKAVVSLRCIACGVNLNSSRQSRIVGGES 261
Query: 223 SLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD-LYLPKSWTIQVGLV--SLLD 279
+L WPWQ SL Q H+CGGS+ITP WI+TAAHCV L P WT G++ S +
Sbjct: 262 ALPGAWPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMF 321
Query: 280 NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCW 339
A + VEK++ H Y K NDIALMKL PLTFN++++PVCLPN ++CW
Sbjct: 322 YGA-GYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCW 380
Query: 340 TSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQG 399
SGWGATE+ G S VLN A V LI + CN R VY +I+P+M+CAG+L G VDSCQG
Sbjct: 381 ISGWGATEE-KGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQG 439
Query: 400 DSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERD 451
DSGGPLV + +W L+G TS+G GCA+ +PGVY V F DWI+ QM D
Sbjct: 440 DSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMRAD 491
>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
Length = 567
Score = 278 bits (712), Expect = 6e-75
Identities = 154/409 (37%), Positives = 221/409 (54%), Gaps = 21/409 (5%)
Query: 53 VIGIIALILALAIGLGIHFDC----SGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCV 108
+IG + L++AL + L I F +G C + RCDGV DCK DE CV
Sbjct: 168 LIGCVLLLIALVVSLIILFQFWQGHTGIRYKEQRESCPKHAVRCDGVVDCKLKSDELGCV 227
Query: 109 RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFR 166
R ++L++++ +S W +CS +W Y+ C QLGF S + + F
Sbjct: 228 RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDFANSF- 286
Query: 167 EEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLS 226
+ + + + +LH R C S ++LQC+ CG R + RIVGG ++ S
Sbjct: 287 -SILRYNSTIQE----SLH-----RSECPSQRYISLQCSHCG-LRAMTGRIVGGALASDS 335
Query: 227 QWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLY--LPKSWTIQVGLVSLLDNPAPS 284
+WPWQ SL F H+CGG++I W++TAAHC + + + W + G +L P +
Sbjct: 336 KWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSNLHQLPEAA 395
Query: 285 HLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWG 344
+ E I+ +S Y + DIALM+L+ PLT + I P CLP + F + CW +G+G
Sbjct: 396 SIAE-IIINSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFG 454
Query: 345 ATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGP 404
T + SP L V LI K CN VY ++P M+CAG L GG DSCQGDSGGP
Sbjct: 455 KTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGP 514
Query: 405 LVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLK 453
LVC++ W L G TS+G GC + NKPGVYT+VT L WI+ +ME +++
Sbjct: 515 LVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVR 563
>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
Length = 457
Score = 270 bits (689), Expect = 3e-72
Identities = 140/349 (40%), Positives = 191/349 (54%), Gaps = 10/349 (2%)
Query: 109 RVGGQNAVL--QVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFR 166
R+ ++ +L QV W +C + W C LG + ++ ++
Sbjct: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172
Query: 167 EEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLS 226
+EF + L L + R C SG VV+L+C+ CG R +SRIVGG
Sbjct: 173 QEFAQLSPRLGG----FLEEAWQPRNNCTSGQVVSLRCSECG-ARPLASRIVGGQSVAPG 227
Query: 227 QWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPK--SWTIQVGLVS-LLDNPAP 283
+WPWQAS+ H CGGSV+ P W++TAAHC++ L + SW + GLVS P
Sbjct: 228 RWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQ 287
Query: 284 SHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGW 343
LVE+I+ H Y + D+AL++L L F++ + VCLP E++FP G CW SGW
Sbjct: 288 GALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGW 347
Query: 344 GATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGG 403
G T +S +L VPL S ++CN VY G ++P MLCAGYL G D+CQGDSGG
Sbjct: 348 GHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGG 407
Query: 404 PLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDL 452
PLVC + W+LVG S+G GCAE N PGVY +V FLDWIH+ + L
Sbjct: 408 PLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSL 456
>gi|33695155 hepsin [Homo sapiens]
Length = 417
Score = 249 bits (637), Expect = 3e-66
Identities = 139/360 (38%), Positives = 192/360 (53%), Gaps = 26/360 (7%)
Query: 108 VRVGGQNAVLQVF--TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQF 165
V+V +A L VF T +W+ +CS A ++C ++GF ++ L V +
Sbjct: 54 VQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANG 113
Query: 166 REEFVSIDHLLPDDKVTALHHSVYVRE-----GCASGHVVTLQCTACGHRRGYSSRIVGG 220
F +D L H+ + E C G + C CG R+ RIVGG
Sbjct: 114 TSGFFCVDE-------GRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGG 166
Query: 221 NMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS-WTIQVGLVSLLD 279
+ L +WPWQ SL++ G HLCGGS+++ W++TAAHC + S W + G V+
Sbjct: 167 RDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226
Query: 280 NPAPSHLVEKIVYHSKYKPKR------LGNDIALMKLAGPLTFNEMIQPVCLPNSEENFP 333
V+ +VYH Y P R NDIAL+ L+ PL E IQPVCLP + +
Sbjct: 227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALV 286
Query: 334 DGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGG 393
DGK+C +GWG T+ G + VL A VP+ISN +CN D YG I P M CAGY GG
Sbjct: 287 DGKICTVTGWGNTQY-YGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGG 345
Query: 394 VDSCQGDSGGPLVCQE----RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQME 449
+D+CQGDSGGP VC++ W+L G S+G GCA KPGVYT+V+ F +WI + ++
Sbjct: 346 IDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
>gi|4504481 hepsin [Homo sapiens]
Length = 417
Score = 249 bits (637), Expect = 3e-66
Identities = 139/360 (38%), Positives = 192/360 (53%), Gaps = 26/360 (7%)
Query: 108 VRVGGQNAVLQVF--TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQF 165
V+V +A L VF T +W+ +CS A ++C ++GF ++ L V +
Sbjct: 54 VQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANG 113
Query: 166 REEFVSIDHLLPDDKVTALHHSVYVRE-----GCASGHVVTLQCTACGHRRGYSSRIVGG 220
F +D L H+ + E C G + C CG R+ RIVGG
Sbjct: 114 TSGFFCVDE-------GRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGG 166
Query: 221 NMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS-WTIQVGLVSLLD 279
+ L +WPWQ SL++ G HLCGGS+++ W++TAAHC + S W + G V+
Sbjct: 167 RDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226
Query: 280 NPAPSHLVEKIVYHSKYKPKR------LGNDIALMKLAGPLTFNEMIQPVCLPNSEENFP 333
V+ +VYH Y P R NDIAL+ L+ PL E IQPVCLP + +
Sbjct: 227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALV 286
Query: 334 DGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGG 393
DGK+C +GWG T+ G + VL A VP+ISN +CN D YG I P M CAGY GG
Sbjct: 287 DGKICTVTGWGNTQY-YGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGG 345
Query: 394 VDSCQGDSGGPLVCQE----RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQME 449
+D+CQGDSGGP VC++ W+L G S+G GCA KPGVYT+V+ F +WI + ++
Sbjct: 346 IDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
>gi|223942069 enterokinase precursor [Homo sapiens]
Length = 1019
Score = 246 bits (628), Expect = 3e-65
Identities = 146/393 (37%), Positives = 213/393 (54%), Gaps = 30/393 (7%)
Query: 67 LGIHFDCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRCVR----VGGQNAVLQVFT 121
LGI C ++C++ +C+ L+ CDG C+DG DE CVR N +++
Sbjct: 637 LGIPEPCKADHFQCKNG-ECVPLVNLCDGHLHCEDGSDEADCVRFFNGTTNNNGLVRFRI 695
Query: 122 AASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKV 181
+ W T C+++W +N C LG S SS + S +G FV ++ PD
Sbjct: 696 QSIWHTACAENWTTQISNDVCQLLGLGSGNSSKP--IFSTDGG---PFVKLN-TAPDG-- 747
Query: 182 TALHHSVYVREGCASGHVVTLQCT--ACGHR---RGYSSRIVGGNMSLLSQWPWQASLQF 236
H + + C ++ LQC +CG + + + +IVGG+ + WPW L +
Sbjct: 748 ---HLILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYY 804
Query: 237 QGYHLCGGSVITPLWIITAAHCVYDLYL-PKSWTIQVGLVSLLDNPAPS---HLVEKIVY 292
G LCG S+++ W+++AAHCVY L P WT +GL + +P L+++IV
Sbjct: 805 GGRLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVI 864
Query: 293 HSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGD 352
+ Y +R NDIA+M L + + + IQP+CLP + FP G+ C +GWG T G
Sbjct: 865 NPHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWG-TVVYQGT 923
Query: 353 ASPVLNHAAVPLISNKICNHR-DVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERR 411
+ +L A VPL+SN+ C + Y I+ +M+CAGY GG+DSCQGDSGGPL+CQE
Sbjct: 924 TANILQEADVPLLSNERCQQQMPEYN--ITENMICAGYEEGGIDSCQGDSGGPLMCQENN 981
Query: 412 LWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444
W L G TSFG CA N+PGVY RV+ F +WI
Sbjct: 982 RWFLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014
Score = 30.0 bits (66), Expect = 4.5
Identities = 15/43 (34%), Positives = 20/43 (46%), Gaps = 1/43 (2%)
Query: 63 LAIGLGIHFDC-SGKYRCRSSFKCIELIARCDGVSDCKDGEDE 104
LA + +C G C + CI+ CDG +C DG DE
Sbjct: 174 LATPGNVSIECLPGSSPCTDALTCIKADLFCDGEVNCPDGSDE 216
>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
sapiens]
Length = 437
Score = 243 bits (621), Expect = 2e-64
Identities = 149/431 (34%), Positives = 219/431 (50%), Gaps = 39/431 (9%)
Query: 44 LPLKFFPIIVIGIIALILALA------IGLGIHFDCSGKYRCRSSFKCIELIARCDGVSD 97
+P++ F + I II +L+LA + + + D + C I CDG D
Sbjct: 24 IPMETFRKVGIPIIIALLSLASIIIVVVLIKVILD-KYYFLCGQPLHFIPRKQLCDGELD 82
Query: 98 CKDGEDEYRCV-----------RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQ 144
C GEDE CV R+ + LQV +A+ W + C D++ A AC Q
Sbjct: 83 CPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQ 142
Query: 145 LGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREG---CASGHVVT 201
+G+ S + FR + D L ++T + +R C SG +V+
Sbjct: 143 MGYSS------------KPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVS 190
Query: 202 LQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD 261
L C ACG + + R+VGG + + WPWQ S+Q+ H+CGGS++ P W++TAAHC
Sbjct: 191 LHCLACG-KSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRK 249
Query: 262 LYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQ 321
+W ++ G L PS V KI+ NDIALMKL PLTF+ ++
Sbjct: 250 HTDVFNWKVRAGSDKL--GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 307
Query: 322 PVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIIS 381
P+CLP +E W GWG T+ G S +L A+V +I + CN D Y G ++
Sbjct: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVT 367
Query: 382 PSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFL 441
M+CAG GGVD+CQGDSGGPL+ Q + W +VG S+G GC + PGVYT+V+++L
Sbjct: 368 EKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTPGVYTKVSAYL 426
Query: 442 DWIHEQMERDL 452
+WI+ + +L
Sbjct: 427 NWIYNVWKAEL 437
>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
sapiens]
Length = 432
Score = 239 bits (610), Expect = 4e-63
Identities = 147/431 (34%), Positives = 216/431 (50%), Gaps = 44/431 (10%)
Query: 44 LPLKFFPIIVIGIIALILALA------IGLGIHFDCSGKYRCRSSFKCIELIARCDGVSD 97
+P++ F + I II +L+LA + + + D + C I CDG D
Sbjct: 24 IPMETFRKVGIPIIIALLSLASIIIVVVLIKVILD-KYYFLCGQPLHFIPRKQLCDGELD 82
Query: 98 CKDGEDEYRCV-----------RVGGQNAVLQVFTAAS--WKTMCSDDWKGHYANVACAQ 144
C GEDE CV R+ + LQV +A+ W + C D++ A AC Q
Sbjct: 83 CPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQ 142
Query: 145 LGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREG---CASGHVVT 201
+G+ V + D L ++T + +R C SG +V+
Sbjct: 143 MGYSRAVE-----------------IGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVS 185
Query: 202 LQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD 261
L C ACG + + R+VGG + + WPWQ S+Q+ H+CGGS++ P W++TAAHC
Sbjct: 186 LHCLACG-KSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRK 244
Query: 262 LYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQ 321
+W ++ G L PS V KI+ NDIALMKL PLTF+ ++
Sbjct: 245 HTDVFNWKVRAGSDKL--GSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVR 302
Query: 322 PVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIIS 381
P+CLP +E W GWG T+ G S +L A+V +I + CN D Y G ++
Sbjct: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVT 362
Query: 382 PSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFL 441
M+CAG GGVD+CQGDSGGPL+ Q + W +VG S+G GC + PGVYT+V+++L
Sbjct: 363 EKMMCAGIPEGGVDTCQGDSGGPLMYQSDQ-WHVVGIVSWGYGCGGPSTPGVYTKVSAYL 421
Query: 442 DWIHEQMERDL 452
+WI+ + +L
Sbjct: 422 NWIYNVWKAEL 432
>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
Length = 418
Score = 210 bits (535), Expect = 2e-54
Identities = 143/413 (34%), Positives = 206/413 (49%), Gaps = 35/413 (8%)
Query: 51 IIVIGIIALILALAIGLGIHFDCSGK--YRCRSSFKCIELIARCDGVSDCKDGEDEYRCV 108
I+V G++ ILA+ I L ++F + Y RSSF+ + + S EYR +
Sbjct: 22 IVVAGVV--ILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQ---EYRTL 76
Query: 109 RVGGQNAVLQVFTAASWKTM--------CSDDWKGHYANVACA-QLGFPSYVSSDNLRVS 159
++ + + F ++ + D G A+V Q + +S R+
Sbjct: 77 SGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASMKSRIE 136
Query: 160 SLEGQFREEFVSIDHLLPDDKVTALHHSV----YVREGCASGHVVTLQCTACGHRRGYSS 215
S+ Q +++ + P ++T+L + E A ++TL
Sbjct: 137 SVLRQMLNNSGNLE-INPSTEITSLTDQAAANWLINECGAGPDLITLS----------EQ 185
Query: 216 RIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLV 275
RI+GG + WPWQ SL+ H CGGS+I +WI+TAAHC P+ W G+
Sbjct: 186 RILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGIS 245
Query: 276 SLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDG 335
+ P V I+ H+ YK NDIAL++L +TF + I VCLP + +N P G
Sbjct: 246 TTF--PKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPG 303
Query: 336 KVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVD 395
+ +GWGA E AG P L V +ISN +CN Y G I MLCAG GGVD
Sbjct: 304 STAYVTGWGAQEY-AGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVD 362
Query: 396 SCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQ 447
+CQGDSGGPLV ++ RRLW +VG S+G C +KPGVYTRVT++LDWI +Q
Sbjct: 363 ACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQ 415
>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
Length = 638
Score = 209 bits (531), Expect = 5e-54
Identities = 103/241 (42%), Positives = 147/241 (60%), Gaps = 7/241 (2%)
Query: 214 SSRIVGGNMSLLSQWPWQASLQFQ---GYHLCGGSVITPLWIITAAHCVYDLYLPKSWTI 270
S+RIVGG S +WPWQ SLQ + HLCGGS+I W++TAAHC L L W I
Sbjct: 388 STRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDVWRI 447
Query: 271 QVGLVSLLD--NPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNS 328
G+++L D P +++I+ H YK +DIAL+KL PL + E +P+CLP+
Sbjct: 448 YSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLPSK 507
Query: 329 EENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAG 388
+ CW +GWG +++ G+ +L +PL++N+ C R I+ M+CAG
Sbjct: 508 GDTSTIYTNCWVTGWGFSKE-KGEIQNILQKVNIPLVTNEECQKR-YQDYKITQRMVCAG 565
Query: 389 YLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQM 448
Y GG D+C+GDSGGPLVC+ +W+LVG TS+G GCA +PGVYT+V ++DWI E+
Sbjct: 566 YKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILEKT 625
Query: 449 E 449
+
Sbjct: 626 Q 626
>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
Length = 416
Score = 202 bits (514), Expect = 5e-52
Identities = 103/255 (40%), Positives = 152/255 (59%), Gaps = 10/255 (3%)
Query: 195 ASGHVVTLQCTACGHRRGYS----SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPL 250
A+ ++T C CG + S ++IV G SL WPWQAS+Q++G H CG S+I+
Sbjct: 161 AASEMLTNNC--CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSR 218
Query: 251 WIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKL 310
W+++AAHC K WT+ G+V ++ P + V+ I++H Y L +DIAL++L
Sbjct: 219 WLLSAAHCFAKKNNSKDWTVNFGIV--VNKPYMTRKVQNIIFHENYSSPGLHDDIALVQL 276
Query: 311 AGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKIC 370
A ++F E I+ +CLP ++ + +GWG T G +L + +I NKIC
Sbjct: 277 AEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWG-TLYMNGSFPVILQEDFLKIIDNKIC 335
Query: 371 NHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVN 429
N Y G ++ +MLCAG+++G D+CQ DSGGPL + R +W LVG S+G GC + N
Sbjct: 336 NASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKN 395
Query: 430 KPGVYTRVTSFLDWI 444
KPGVYTRVTS+ +WI
Sbjct: 396 KPGVYTRVTSYRNWI 410
>gi|205360905 testis-specific serine protease 1 [Homo sapiens]
Length = 318
Score = 197 bits (502), Expect = 1e-50
Identities = 105/258 (40%), Positives = 145/258 (56%), Gaps = 21/258 (8%)
Query: 206 ACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLP 265
ACGHR ++ + GG S +WPWQASL+ + H CGGS+++ W+++AAHC Y P
Sbjct: 45 ACGHREIHAL-VAGGVESARGRWPWQASLRLRRRHRCGGSLLSRRWVLSAAHCFQKHYYP 103
Query: 266 KSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYK-------PKRLG---NDIALMKLAGPLT 315
WT+Q+G L P P +L Y S+YK P LG NDIAL++LA +T
Sbjct: 104 SEWTVQLG--ELTSRPTPWNLR---AYSSRYKVQDIIVNPDALGVLRNDIALLRLASSVT 158
Query: 316 FNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLN--HAAVPLISNKICNH- 372
+N IQP+C+ +S NF CW +GWG P N A V +++N CN+
Sbjct: 159 YNAYIQPICIESSTFNFVHRPDCWVTGWGLISPSGTPLPPPYNLREAQVTILNNTRCNYL 218
Query: 373 --RDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNK 430
+ +I SM CAG G VD+C+GDSGGPLVC + LW VG S+G+ C + N+
Sbjct: 219 FEQPSSRSMIWDSMFCAGAEDGSVDTCKGDSGGPLVCDKDGLWYQVGIVSWGMDCGQPNR 278
Query: 431 PGVYTRVTSFLDWIHEQM 448
PGVYT ++ + WI M
Sbjct: 279 PGVYTNISVYFHWIRRVM 296
>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
Length = 438
Score = 195 bits (495), Expect = 8e-50
Identities = 100/233 (42%), Positives = 138/233 (59%), Gaps = 5/233 (2%)
Query: 214 SSRIVGGNMSLLS-QWPWQASLQFQGY-HLCGGSVITPLWIITAAHCVYDLYLPKSWTIQ 271
+ RIV G + + +WPWQASLQ G H CG S+I+ W++TAAHC + P W
Sbjct: 203 TQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIAT 262
Query: 272 VGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEEN 331
G + + PA V KI+ H Y + NDIAL++L+ + F+ ++Q VCLP+S
Sbjct: 263 FG--ATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIK 320
Query: 332 FPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLT 391
P + +G+G+ D G L A V IS +CN +DVY G+I+P MLCAG++
Sbjct: 321 LPPKTSVFVTGFGSIVDD-GPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFME 379
Query: 392 GGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444
G +D+C+GDSGGPLV +W +VG S+G CA KPGVYTRVT + DWI
Sbjct: 380 GKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
>gi|148613878 acrosin precursor [Homo sapiens]
Length = 421
Score = 194 bits (492), Expect = 2e-49
Identities = 96/244 (39%), Positives = 134/244 (54%), Gaps = 15/244 (6%)
Query: 216 RIVGGNMSLLSQWPWQASLQF-----QGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTI 270
RIVGG + WPW SLQ YH CGGS++ W++TAAHC W +
Sbjct: 42 RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWRL 101
Query: 271 QVGLVSL-------LDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPV 323
G + + P VEKI+ H KY GNDIAL+++ P++ I P
Sbjct: 102 VFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGPG 161
Query: 324 CLPNSEENFPDG-KVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 382
CLP+ + P G + CW +GWG E+ A S +L A V LI +CN Y G + P
Sbjct: 162 CLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQP 221
Query: 383 SMLCAGYLTGGVDSCQGDSGGPLVCQERR--LWKLVGATSFGIGCAEVNKPGVYTRVTSF 440
+ +CAGY G +D+CQGDSGGPL+C++ + + +VG TS+G+GCA +PG+YT +
Sbjct: 222 TNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWPY 281
Query: 441 LDWI 444
L+WI
Sbjct: 282 LNWI 285
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 193 bits (491), Expect = 2e-49
Identities = 123/379 (32%), Positives = 198/379 (52%), Gaps = 26/379 (6%)
Query: 85 CIELIARCDGVSDCKDGEDEYRCVRVG---GQNAVLQVFTAASWKTMCSDDWKGHYANVA 141
C+ CDG +DC D DE+ CV + ++ L V AA+ +C+D W+ + +A
Sbjct: 667 CVSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHHVCADGWQEILSQLA 726
Query: 142 CAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVT 201
C Q+G + ++ E + ++++ T LH + + C S ++
Sbjct: 727 CKQMG----LGEPSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCESRSKIS 782
Query: 202 LQCTA--CGHRRG--YSSRIVGGNMSLLSQWPWQASLQFQ-GYHLCGGSVITPLWIITAA 256
L CT CG R + RI+GG S +WPWQ SLQ + H+CG +I W++T A
Sbjct: 783 LLCTKQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVA 842
Query: 257 HCVYDLYLPKSWTIQVGLVSLLDNPA---PSHLVEKIVYHSKYKPKRLGNDIALMKLAGP 313
HC W + +G ++ LD+P+ + V+ I+ H +Y + DI++++L+
Sbjct: 843 HCFEGRENAAVWKVVLG-INNLDHPSVFMQTRFVKTIILHPRYSRAVVDYDISIVELSED 901
Query: 314 LTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPV-LNHAAVPLISNKIC-N 371
++ ++PVCLPN E+ C+ +GWG G+ P L V +IS + C +
Sbjct: 902 ISETGYVRPVCLPNPEQWLEPDTYCYITGWGHM----GNKMPFKLQEGEVRIISLEHCQS 957
Query: 372 HRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGC-AEVN 429
+ D+ I+ M+CAGY +G VDSC GDSGGPLVC++ W L G TS+G C ++V
Sbjct: 958 YFDMK--TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVL 1015
Query: 430 KPGVYTRVTSFLDWIHEQM 448
PGVY+ V+ F++WI Q+
Sbjct: 1016 GPGVYSNVSYFVEWIKRQI 1034
Score = 36.6 bits (83), Expect = 0.048
Identities = 16/33 (48%), Positives = 19/33 (57%), Gaps = 1/33 (3%)
Query: 75 GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
G CR+ +CI +CDG DCKDG DE C
Sbjct: 383 GLVECRNG-QCIPSTFQCDGDEDCKDGSDEENC 414
Score = 35.8 bits (81), Expect = 0.082
Identities = 16/37 (43%), Positives = 22/37 (59%), Gaps = 2/37 (5%)
Query: 72 DCS-GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
+CS ++CRS +C+ RCDG +DC D DE C
Sbjct: 579 ECSPSHFKCRSG-QCVLASRRCDGQADCDDDSDEENC 614
Score = 31.6 bits (70), Expect = 1.6
Identities = 15/39 (38%), Positives = 19/39 (48%), Gaps = 2/39 (5%)
Query: 70 HFDCSGK-YRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
H +CS + C + KC+ CDG DC D DE C
Sbjct: 303 HCNCSENLFHCHTG-KCLNYSLVCDGYDDCGDLSDEQNC 340
Score = 29.3 bits (64), Expect = 7.7
Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 3/38 (7%)
Query: 72 DCSG--KYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
DC+ ++RC +CI + CDG DC D DE C
Sbjct: 341 DCNPTTEHRCGDG-RCIAMEWVCDGDHDCVDKSDEVNC 377
>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
Length = 423
Score = 193 bits (491), Expect = 2e-49
Identities = 105/246 (42%), Positives = 138/246 (56%), Gaps = 14/246 (5%)
Query: 207 CGHRR----GYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDL 262
CG RR G S RIVGG +WPWQASLQ+ G H CG ++I W+++AAHC
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
Query: 263 YLPKSWTIQVGLVSLLDNPAPSHL---VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEM 319
P WT G+ PS + + +I+ H KYK DI+L +L+ P+ +
Sbjct: 238 KNPARWTASFGVTI-----KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292
Query: 320 IQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGI 379
+ VCLP++ F G V + +G+GA ++ G + L A V LI CN Y
Sbjct: 293 VHRVCLPDASYEFQPGDVMFVTGFGALKND-GYSQNHLRQAQVTLIDATTCNEPQAYNDA 351
Query: 380 ISPSMLCAGYLTGGVDSCQGDSGGPLVCQERR-LWKLVGATSFGIGCAEVNKPGVYTRVT 438
I+P MLCAG L G D+CQGDSGGPLV + R +W L G S+G CA+ NKPGVYTRVT
Sbjct: 352 ITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVT 411
Query: 439 SFLDWI 444
+ DWI
Sbjct: 412 ALRDWI 417
>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
Length = 423
Score = 193 bits (491), Expect = 2e-49
Identities = 105/246 (42%), Positives = 138/246 (56%), Gaps = 14/246 (5%)
Query: 207 CGHRR----GYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDL 262
CG RR G S RIVGG +WPWQASLQ+ G H CG ++I W+++AAHC
Sbjct: 178 CGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTY 237
Query: 263 YLPKSWTIQVGLVSLLDNPAPSHL---VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEM 319
P WT G+ PS + + +I+ H KYK DI+L +L+ P+ +
Sbjct: 238 KNPARWTASFGVTI-----KPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNA 292
Query: 320 IQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGI 379
+ VCLP++ F G V + +G+GA ++ G + L A V LI CN Y
Sbjct: 293 VHRVCLPDASYEFQPGDVMFVTGFGALKND-GYSQNHLRQAQVTLIDATTCNEPQAYNDA 351
Query: 380 ISPSMLCAGYLTGGVDSCQGDSGGPLVCQERR-LWKLVGATSFGIGCAEVNKPGVYTRVT 438
I+P MLCAG L G D+CQGDSGGPLV + R +W L G S+G CA+ NKPGVYTRVT
Sbjct: 352 ITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVT 411
Query: 439 SFLDWI 444
+ DWI
Sbjct: 412 ALRDWI 417
>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
Length = 717
Score = 193 bits (490), Expect = 3e-49
Identities = 132/382 (34%), Positives = 179/382 (46%), Gaps = 41/382 (10%)
Query: 75 GKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSD--D 132
G +RC S C+ RCDGV+DC D DE CV Q A +C D
Sbjct: 361 GSFRCSSGL-CVPQAQRCDGVNDCFDESDELFCV--SPQPACNTSSFRQHGPLICDGFRD 417
Query: 133 WKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLL--PDDKVTALHHSVYV 190
+ C Q S ++ + FR++ D + PD
Sbjct: 418 CENGRDEQNCTQ----SIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSD--------- 464
Query: 191 REGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPL 250
EGC C RI+GG +L WPWQ SL F G CG SVI+
Sbjct: 465 EEGCT-----------CSRSSSALHRIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISRE 513
Query: 251 WIITAAHCVYDLYL--PKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALM 308
W+++AAHC + L P WT +G+ + N V +IV H Y + DIAL+
Sbjct: 514 WLLSAAHCFHGNRLSDPTPWTAHLGMY-VQGNAKFVSPVRRIVVHEYYNSQTFDYDIALL 572
Query: 309 KL--AGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLIS 366
+L A P T ++IQP+C+P + + G+ CW +GWG + S VL A V LI
Sbjct: 573 QLSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELID 632
Query: 367 NKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERR--LWKLVGATSFGIG 424
+C Y GII+ MLCAG ++G D+C+GDSGGPL C+ + W L G S+G G
Sbjct: 633 QTLC--VSTY-GIITSRMLCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHG 689
Query: 425 CAEVNKPGVYTRVTSFLDWIHE 446
N PGVYTRV++F+ WIH+
Sbjct: 690 SGRPNFPGVYTRVSNFVPWIHK 711
Score = 32.0 bits (71), Expect = 1.2
Identities = 17/43 (39%), Positives = 22/43 (51%), Gaps = 7/43 (16%)
Query: 72 DCSGKYRCRS-SFKCIELI------ARCDGVSDCKDGEDEYRC 107
+C+ C + +FKC I A+CDG DC DG DE C
Sbjct: 426 NCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDCPDGSDEEGC 468
>gi|4505881 plasminogen [Homo sapiens]
Length = 810
Score = 192 bits (489), Expect = 4e-49
Identities = 99/237 (41%), Positives = 141/237 (59%), Gaps = 7/237 (2%)
Query: 216 RIVGGNMSLLSQWPWQASLQFQ-GYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGL 274
R+VGG ++ WPWQ SL+ + G H CGG++I+P W++TAAHC+ P S+ + +G
Sbjct: 580 RVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILGA 639
Query: 275 VSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPD 334
++ H+ E V +P R DIAL+KL+ P + + P CLP+ D
Sbjct: 640 HQEVN--LEPHVQEIEVSRLFLEPTR--KDIALLKLSSPAVITDKVIPACLPSPNYVVAD 695
Query: 335 GKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGV 394
C+ +GWG T+ G + +L A +P+I NK+CN + G + + LCAG+L GG
Sbjct: 696 RTECFITGWGETQGTFG--AGLLKEAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGT 753
Query: 395 DSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERD 451
DSCQGDSGGPLVC E+ + L G TS+G+GCA NKPGVY RV+ F+ WI M +
Sbjct: 754 DSCQGDSGGPLVCFEKDKYILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMRNN 810
>gi|21614531 testisin isoform 2 [Homo sapiens]
Length = 312
Score = 192 bits (489), Expect = 4e-49
Identities = 101/257 (39%), Positives = 146/257 (56%), Gaps = 21/257 (8%)
Query: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVY-DLYLP 265
CG RR +SRIVGG + L +WPWQ SL+ H+CG S+++ W +TAAHC DL P
Sbjct: 33 CG-RRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETDLSDP 91
Query: 266 KSWTIQVGLVSLLDN--PAPSHLVEKIVYHSKYKPKRLGN---DIALMKLAGPLTFNEMI 320
W +Q G ++ + + ++ V + P+ LGN DIAL+KL+ P+T+ + I
Sbjct: 92 SGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTKHI 151
Query: 321 QPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASP-VLNHAAVPLISNKICNH------- 372
QP+CL S F + CW +GWG ++ SP L V +I+N +CNH
Sbjct: 152 QPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKYSF 211
Query: 373 -RDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKP 431
+D++G M+CAG GG D+C GDSGGPL C + LW +G S+G+GC N+P
Sbjct: 212 RKDIFG-----DMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPNRP 266
Query: 432 GVYTRVTSFLDWIHEQM 448
GVYT ++ +WI + M
Sbjct: 267 GVYTNISHHFEWIQKLM 283
>gi|5803197 testisin isoform 1 [Homo sapiens]
Length = 314
Score = 192 bits (487), Expect = 7e-49
Identities = 101/259 (38%), Positives = 146/259 (56%), Gaps = 23/259 (8%)
Query: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVY---DLY 263
CG RR +SRIVGG + L +WPWQ SL+ H+CG S+++ W +TAAHC DL
Sbjct: 33 CG-RRVITSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALTAAHCFETYSDLS 91
Query: 264 LPKSWTIQVGLVSLLDN--PAPSHLVEKIVYHSKYKPKRLGN---DIALMKLAGPLTFNE 318
P W +Q G ++ + + ++ V + P+ LGN DIAL+KL+ P+T+ +
Sbjct: 92 DPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRYLGNSPYDIALVKLSAPVTYTK 151
Query: 319 MIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASP-VLNHAAVPLISNKICNH----- 372
IQP+CL S F + CW +GWG ++ SP L V +I+N +CNH
Sbjct: 152 HIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPHTLQEVQVAIINNSMCNHLFLKY 211
Query: 373 ---RDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVN 429
+D++G M+CAG GG D+C GDSGGPL C + LW +G S+G+GC N
Sbjct: 212 SFRKDIFG-----DMVCAGNAQGGKDACFGDSGGPLACNKNGLWYQIGVVSWGVGCGRPN 266
Query: 430 KPGVYTRVTSFLDWIHEQM 448
+PGVYT ++ +WI + M
Sbjct: 267 RPGVYTNISHHFEWIQKLM 285
>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
Length = 1059
Score = 191 bits (485), Expect = 1e-48
Identities = 104/247 (42%), Positives = 148/247 (59%), Gaps = 8/247 (3%)
Query: 207 CGHRRGYS--SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYL 264
CG R +R+VGG + + PWQ SL+ H CG +V+ W+++AAHC ++
Sbjct: 492 CGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC-FNHTK 550
Query: 265 PKSWTIQVGLVSLLD-NPAPSHL-VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQP 322
+ +G SLL +P + + ++V H Y P L D+A+++LA PL FN+ IQP
Sbjct: 551 VEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQP 610
Query: 323 VCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 382
VCLP + + FP G+ C SGWG T++G +L A+V +I K C+ +Y ++
Sbjct: 611 VCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCS--VLYNFSLTD 668
Query: 383 SMLCAGYLTGGVDSCQGDSGGPLVCQER-RLWKLVGATSFGIGCAEVNKPGVYTRVTSFL 441
M+CAG+L G VDSCQGDSGGPL C+E ++ L G S+GIGCA+V KPGVYTR+T
Sbjct: 669 RMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLK 728
Query: 442 DWIHEQM 448
WI E M
Sbjct: 729 GWILEIM 735
Score = 191 bits (484), Expect = 2e-48
Identities = 102/236 (43%), Positives = 133/236 (56%), Gaps = 5/236 (2%)
Query: 214 SSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVG 273
+ RIVGG + ++PWQASL+ H CG ++I W+++AAHC + P W VG
Sbjct: 200 AGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDPTKWVAYVG 259
Query: 274 LVSLLDNPAPS--HLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEEN 331
L + A + V +IV H Y D+A+++L PL F IQPVCLP +
Sbjct: 260 ATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVCLPAATHI 319
Query: 332 FPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLT 391
FP K C SGWG ++ VL A V L+ +C +YG ++ M+CAGYL
Sbjct: 320 FPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHSLTDRMVCAGYLD 377
Query: 392 GGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHE 446
G VDSCQGDSGGPLVC+E + L G S+GIGCAE +PGVY RVT DWI E
Sbjct: 378 GKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDWILE 433
Score = 182 bits (461), Expect = 7e-46
Identities = 101/250 (40%), Positives = 139/250 (55%), Gaps = 7/250 (2%)
Query: 203 QCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGY-HLCGGSVITPLWIITAAHCVYD 261
Q CG +RIVGG+ + +WPWQ SL + H CG ++ W+++AAHC +D
Sbjct: 813 QLPDCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHC-FD 871
Query: 262 LYL-PKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMI 320
+Y PK W +G L V +I H Y L D+AL++LAGP+ + ++
Sbjct: 872 VYGDPKQWAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLV 931
Query: 321 QPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGII 380
+P+CLP PDG C +GWG+ +G G + L AAV L+S + C R Y I
Sbjct: 932 RPICLPEPAPRPPDGTRCVITGWGSVREG-GSMARQLQKAAVRLLSEQTC--RRFYPVQI 988
Query: 381 SPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPGVYTRVTS 439
S MLCAG+ GGVDSC GD+GGPL C+E W L G TS+G GC + PGVYTRV +
Sbjct: 989 SSRMLCAGFPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAA 1048
Query: 440 FLDWIHEQME 449
WI + ++
Sbjct: 1049 VRGWIGQHIQ 1058
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 190 bits (482), Expect = 3e-48
Identities = 128/382 (33%), Positives = 182/382 (47%), Gaps = 72/382 (18%)
Query: 77 YRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCSDDWKGH 136
+RC S+ KC+ +C+G DC DG DE C +V V T C
Sbjct: 530 FRC-SNGKCLSKSQQCNGKDDCGDGSDEASCPKVN-------VVTCTKHTYRC------- 574
Query: 137 YANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDHLLPDDKVTALHHSVYVREGCAS 196
N C G P +G +E C+
Sbjct: 575 -LNGLCLSKGNPE-----------CDG---------------------------KEDCSD 595
Query: 197 GHVVTLQCTACGHRR-GYSSRIVGGNMSLLSQWPWQASLQFQGY-HLCGGSVITPLWIIT 254
G C CG R +R+VGG + +WPWQ SL G H+CG S+I+P W+++
Sbjct: 596 GSDEK-DCD-CGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVS 653
Query: 255 AAHCVYD-----LYLPKSWTIQVGLVSLLDNPAPS---HLVEKIVYHSKYKPKRLGNDIA 306
AAHC D P WT +GL AP +++I+ H + DIA
Sbjct: 654 AAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIA 713
Query: 307 LMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLIS 366
L++L P ++ M++P+CLP++ FP GK W +GWG T+ G G + +L + +I+
Sbjct: 714 LLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYG-GTGALILQKGEIRVIN 772
Query: 367 NKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPL--VCQERRLWKLVGATSFGIG 424
C ++ I+P M+C G+L+GGVDSCQGDSGGPL V + R+++ G S+G G
Sbjct: 773 QTTC--ENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQ-AGVVSWGDG 829
Query: 425 CAEVNKPGVYTRVTSFLDWIHE 446
CA+ NKPGVYTR+ F DWI E
Sbjct: 830 CAQRNKPGVYTRLPLFRDWIKE 851
Score = 39.3 bits (90), Expect = 0.007
Identities = 16/35 (45%), Positives = 21/35 (60%), Gaps = 1/35 (2%)
Query: 73 CSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
C G++ CR+ +CI RCDG +DC D DE C
Sbjct: 453 CPGQFTCRTG-RCIRKELRCDGWADCTDHSDELNC 486
>gi|4503627 coagulation factor XI precursor [Homo sapiens]
Length = 625
Score = 190 bits (482), Expect = 3e-48
Identities = 96/239 (40%), Positives = 139/239 (58%), Gaps = 7/239 (2%)
Query: 216 RIVGGNMSLLSQWPWQASLQFQG---YHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQV 272
RIVGG S+ +WPWQ +L HLCGGS+I WI+TAAHC Y + PK +
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKILRVYS 446
Query: 273 GLVSLLDNPAPSHL--VEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEE 330
G+++ + + V++I+ H +YK G DIAL+KL + + + +P+CLP+ +
Sbjct: 447 GILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTDSQRPICLPSKGD 506
Query: 331 NFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYL 390
CW +GWG + L A +PL++N+ C R G I+ M+CAGY
Sbjct: 507 RNVIYTDCWVTGWGYRKL-RDKIQNTLQKAKIPLVTNEECQKR-YRGHKITHKMICAGYR 564
Query: 391 TGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQME 449
GG D+C+GDSGGPL C+ +W LVG TS+G GCA+ +PGVYT V ++DWI E+ +
Sbjct: 565 EGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNVVEYVDWILEKTQ 623
>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
Length = 811
Score = 189 bits (481), Expect = 3e-48
Identities = 103/245 (42%), Positives = 142/245 (57%), Gaps = 9/245 (3%)
Query: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPK 266
CG +G SSRIVGG +S +WPWQASLQ +G H+CGG++I W+ITAAHC + +
Sbjct: 568 CG-LQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAS 626
Query: 267 S--WTIQVGLVSLLDN--PAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQP 322
+ WT+ +G V S V +++ H ++ D+AL++L P+ + ++P
Sbjct: 627 TVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRP 686
Query: 323 VCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISP 382
VCLP F G CW +GWGA +G G S L V LI +C+ +VY ++P
Sbjct: 687 VCLPARSHFFEPGLHCWITGWGALREG-GPISNALQKVDVQLIPQDLCS--EVYRYQVTP 743
Query: 383 SMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFL 441
MLCAGY G D+CQGDSGGPLVC+ W L G S+G+GC N GVYTR+T +
Sbjct: 744 RMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVI 803
Query: 442 DWIHE 446
WI +
Sbjct: 804 SWIQQ 808
Score = 37.7 bits (86), Expect = 0.022
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 73 CSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRC 107
C ++C+ CI L CDG DC +G DE +C
Sbjct: 491 CRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQC 525
Score = 36.2 bits (82), Expect = 0.063
Identities = 20/64 (31%), Positives = 29/64 (45%), Gaps = 10/64 (15%)
Query: 52 IVIGIIALILALAIGLGIHFD-------CSGKYRCRSSFKCIELIARCDGVSDCKDGEDE 104
I I + I G+ +H+ C G++ C + C+ CDGV DC +G DE
Sbjct: 430 ITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPA---CDGVKDCPNGLDE 486
Query: 105 YRCV 108
CV
Sbjct: 487 RNCV 490
Score = 29.6 bits (65), Expect = 5.9
Identities = 10/17 (58%), Positives = 12/17 (70%)
Query: 91 RCDGVSDCKDGEDEYRC 107
+CDG DC+DG DE C
Sbjct: 550 QCDGRPDCRDGSDEEHC 566
>gi|58218970 protease, serine, 36 [Homo sapiens]
Length = 855
Score = 189 bits (479), Expect = 6e-48
Identities = 105/255 (41%), Positives = 137/255 (53%), Gaps = 15/255 (5%)
Query: 207 CGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYD---LY 263
CG R S+RIVGG+ + WPWQ SL G H+CGGS+I P W+++AAHC L
Sbjct: 38 CG-RPEPSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTLE 96
Query: 264 LPKSWTIQVGLVSLLDNP---APSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMI 320
W++ +G+ S D P A + V IV + Y LG D+AL++LA P + +
Sbjct: 97 PAAEWSVLLGVHSQ-DGPLDGAHTRAVAAIVVPANYSQVELGADLALLRLASPASLGPAV 155
Query: 321 QPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASP-VLNHAAVPLISNKICNHRDVYGGI 379
PVCLP + F G CW +GWG ++ P VL + L+ C G
Sbjct: 156 WPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCLYSQPGP 215
Query: 380 ------ISPSMLCAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGV 433
I P MLCAGY G D+CQGDSGGPLVC+E W G TSFG GC N+PGV
Sbjct: 216 FNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGV 275
Query: 434 YTRVTSFLDWIHEQM 448
+T V ++ WI EQ+
Sbjct: 276 FTAVATYEAWIREQV 290
Score = 86.3 bits (212), Expect = 5e-17
Identities = 63/197 (31%), Positives = 92/197 (46%), Gaps = 21/197 (10%)
Query: 228 WPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPS--- 284
WPW A + G +C G ++ P W++ A HCV P S T+ V L A S
Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCV---LRPGSTTVPYIEVYLGRAGASSLPQ 657
Query: 285 -HLVEKIVYHSKYKPKRLG--NDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTS 341
H V ++V + P+ LG +AL++L+ + + P+CL P G CW
Sbjct: 658 GHQVSRLVISIRL-PQHLGLRPPLALLELSSRVEPSPSALPICL--HPAGIPPGASCWVL 714
Query: 342 GWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDS 401
GW +D A AAV +++ +IC+ +Y GI+ P LC Y G + C+ S
Sbjct: 715 GWKEPQDRVPVA------AAVSILTQRICD--CLYQGILPPGTLCVLYAEGQENRCEMTS 766
Query: 402 GGPLVCQ-ERRLWKLVG 417
PL+CQ W LVG
Sbjct: 767 APPLLCQMTEGSWILVG 783
Score = 78.6 bits (192), Expect = 1e-14
Identities = 63/240 (26%), Positives = 93/240 (38%), Gaps = 46/240 (19%)
Query: 228 WPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS-------WTIQVGLVSLLDN 280
WPW+A + G C G++++ W++ A C D S W + LL +
Sbjct: 334 WPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRV------LLPS 387
Query: 281 PAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWT 340
+ V ++V H +D+AL++L P+ + +PVCLP+ E F G C
Sbjct: 388 RPRAERVARLVQHENASWDN-ASDLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRL 446
Query: 341 SGWGATEDGAGDASPV---------------LNHAAVPLISNKICNHRDVYGGIISPSML 385
+ WG E G + + AAVPL + P L
Sbjct: 447 ARWGRGEPALGPGALLEAELLGGWWCHCLYGRQGAAVPLPGD-------------PPHAL 493
Query: 386 CAGYL-TGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444
C Y V SC DS L+CQE W L G F GC +P + + + WI
Sbjct: 494 CPAYQEKEEVGSCWNDSRWSLLCQEEGTWFLAGIRDFPSGCL---RPRAFFPLQTHGPWI 550
>gi|4506153 prostasin preproprotein [Homo sapiens]
Length = 343
Score = 188 bits (478), Expect = 8e-48
Identities = 90/243 (37%), Positives = 139/243 (57%), Gaps = 9/243 (3%)
Query: 215 SRIVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGL 274
+RI GG+ ++ QWPWQ S+ ++G H+CGGS+++ W+++AAHC + +++ +++G
Sbjct: 43 ARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKLGA 102
Query: 275 VSL--LDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENF 332
L A ++ I+ H Y + DIAL++L+ P+TF+ I+P+CLP + +F
Sbjct: 103 HQLDSYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPICLPAANASF 162
Query: 333 PDGKVCWTSGWGATEDGAGDASPV-LNHAAVPLISNKICN------HRDVYGGIISPSML 385
P+G C +GWG +P L VPLIS + CN + + M+
Sbjct: 163 PNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMV 222
Query: 386 CAGYLTGGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIH 445
CAGY+ GG D+CQGDSGGPL C LW L G S+G C N+PGVYT +S+ WI
Sbjct: 223 CAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQ 282
Query: 446 EQM 448
++
Sbjct: 283 SKV 285
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.139 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,112,774
Number of Sequences: 37866
Number of extensions: 913380
Number of successful extensions: 2864
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 215
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 1781
Number of HSP's gapped (non-prelim): 593
length of query: 454
length of database: 18,247,518
effective HSP length: 106
effective length of query: 348
effective length of database: 14,233,722
effective search space: 4953335256
effective search space used: 4953335256
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.