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Search of human proteins with 4557803
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557803 Niemann-Pick disease, type C1 precursor [Homo
sapiens]
(1278 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens] 2613 0.0
gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapi... 905 0.0
gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapi... 894 0.0
gi|134254450 patched isoform S [Homo sapiens] 130 6e-30
gi|134254435 patched isoform S [Homo sapiens] 130 6e-30
gi|134254468 patched isoform S [Homo sapiens] 130 6e-30
gi|134254452 patched isoform S [Homo sapiens] 130 6e-30
gi|134254432 patched isoform L' [Homo sapiens] 130 6e-30
gi|134254466 patched isoform M [Homo sapiens] 130 6e-30
gi|134254446 patched isoform L [Homo sapiens] 130 6e-30
gi|52145305 patched 2 [Homo sapiens] 120 6e-27
gi|194018513 patched domain containing 3 [Homo sapiens] 108 3e-23
gi|148277106 hypothetical protein LOC442213 [Homo sapiens] 101 5e-21
gi|148271104 patched domain containing 1 [Homo sapiens] 88 5e-17
gi|66932902 SREBF chaperone protein [Homo sapiens] 81 6e-15
gi|149274653 patched domain containing 2 [Homo sapiens] 64 1e-09
gi|25952134 dispatched A [Homo sapiens] 57 9e-08
gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase iso... 49 3e-05
gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isofo... 49 3e-05
gi|25121980 dispatched B [Homo sapiens] 46 2e-04
gi|5031805 insulin receptor substrate 1 [Homo sapiens] 34 1.0
gi|188219559 protein phosphatase 1, regulatory subunit 15B [Homo... 34 1.0
gi|20357588 TBP-associated factor 1 isoform 2 [Homo sapiens] 33 1.7
gi|20357585 TBP-associated factor 1 isoform 1 [Homo sapiens] 33 1.7
gi|89886484 XK, Kell blood group complex subunit-related family,... 33 2.3
gi|32401447 solute carrier family 46, member 3 isoform a [Homo s... 32 3.9
gi|209571533 solute carrier family 46, member 3 isoform b [Homo ... 32 3.9
gi|153791492 eukaryotic translation initiation factor 3, subunit... 32 5.1
gi|83700233 eukaryotic translation initiation factor 3, subunit ... 32 5.1
gi|4503525 eukaryotic translation initiation factor 3, subunit C... 32 5.1
>gi|4557803 Niemann-Pick disease, type C1 precursor [Homo sapiens]
Length = 1278
Score = 2613 bits (6774), Expect = 0.0
Identities = 1278/1278 (100%), Positives = 1278/1278 (100%)
Query: 1 MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQ 60
MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQ
Sbjct: 1 MTARGLALGLLLLLLCPAQVFSQSCVWYGECGIAYGDKRYNCEYSGPPKPLPKDGYDLVQ 60
Query: 61 ELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQF 120
ELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQF
Sbjct: 61 ELCPGFFFGNVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCELTCSPRQSQF 120
Query: 121 LNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKD 180
LNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKD
Sbjct: 121 LNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSNDKALGLLCGKD 180
Query: 181 ADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSC 240
ADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSC
Sbjct: 181 ADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVTAPCSC 240
Query: 241 QDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVS 300
QDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVS
Sbjct: 241 QDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGAFFAVWCYRKRYFVS 300
Query: 301 EYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVF 360
EYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVF
Sbjct: 301 EYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFCVRNPGCVIFFSLVF 360
Query: 361 ITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIY 420
ITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIY
Sbjct: 361 ITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTEQLIIRAPLTDKHIY 420
Query: 421 QPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCT 480
QPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCT
Sbjct: 421 QPYPSGADVPFGPPLDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCT 480
Query: 481 ILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGP 540
ILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGP
Sbjct: 481 ILSVLNYFQNSHSVLDHKKGDDFFVYADYHTHFLYCVRAPASLNDTSLLHDPCLGTFGGP 540
Query: 541 VFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLT 600
VFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLT
Sbjct: 541 VFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPNLT 600
Query: 601 ISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAG 660
ISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAG
Sbjct: 601 ISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAG 660
Query: 661 ILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETL 720
ILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETL
Sbjct: 661 ILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETL 720
Query: 721 DQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFV 780
DQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFV
Sbjct: 721 DQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFV 780
Query: 781 SLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIA 840
SLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIA
Sbjct: 781 SLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIA 840
Query: 841 IFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYT 900
IFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYT
Sbjct: 841 IFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYLHAGPPVYFVLEEGHDYT 900
Query: 901 SSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVD 960
SSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVD
Sbjct: 901 SSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIGFAPSSWIDDYFDWVKPQSSCCRVD 960
Query: 961 NITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYS 1020
NITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYS
Sbjct: 961 NITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYS 1020
Query: 1021 SAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFP 1080
SAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFP
Sbjct: 1021 SAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFP 1080
Query: 1081 YSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFG 1140
YSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFG
Sbjct: 1081 YSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFG 1140
Query: 1141 VMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFS 1200
VMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFS
Sbjct: 1141 VMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFS 1200
Query: 1201 GITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKS 1260
GITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKS
Sbjct: 1201 GITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKS 1260
Query: 1261 CATEERYKGTERERLLNF 1278
CATEERYKGTERERLLNF
Sbjct: 1261 CATEERYKGTERERLLNF 1278
>gi|156231353 Niemann-Pick C1-like protein 1 isoform 2 [Homo sapiens]
Length = 1332
Score = 905 bits (2338), Expect = 0.0
Identities = 517/1290 (40%), Positives = 755/1290 (58%), Gaps = 59/1290 (4%)
Query: 4 RGLALGLLLLLLCPAQVFSQS-----CVWYGECG-------IAYGDKRYNCEYSGPPKPL 51
RG L LLL L ++ ++ C +Y ECG +C + P + +
Sbjct: 7 RGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKI 66
Query: 52 PKDGYDLVQELCPGFFFG-NVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCE 110
D L+Q++CP + G N CC +QL +L+ +L + L+RCP+C N +NL C
Sbjct: 67 TGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCH 126
Query: 111 LTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSND 170
TCSP QS F+NVT V + V + + SFA Y++C V P++
Sbjct: 127 NTCSPNQSLFINVTR----VAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAAT 182
Query: 171 KALGLLCGKDADA-CNATNWIEYMFNKDNGQAPFTITPVFSD---FPVHGMEPMNNATKG 226
A+G +CG A CNA W+ + + NG AP IT + G++P+N
Sbjct: 183 LAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVAR 242
Query: 227 CDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGA 286
C+ES + A CSCQDC+ C +P LD+ + + + L++ +
Sbjct: 243 CNESQGDDVATCSCQDCAASCPAIARPQ---------ALDSTFYLGQMPGSLVLIIILCS 293
Query: 287 FFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFC 346
FAV F P S K S D +S + L + F WG++
Sbjct: 294 VFAVVTILLVGF--RVAPARDK---SKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWV 348
Query: 347 VRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTE 406
P ++ S++ + A ++GLVF +TT+PV+LWSAP+SQAR EK + DQHFGPFFRT
Sbjct: 349 ASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTN 408
Query: 407 QLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENIT--ASYDNETVTL 464
Q+I+ AP + Y G F LD+ +L ++L+LQ + ++ + ++L
Sbjct: 409 QVILTAPNRSSYRYDSLLLGPK-NFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISL 467
Query: 465 QDICLAPLSPYNTN---CTILSVLNYFQNSHSVLDHKKGDDFF---VYADYHTHFLYCVR 518
QDIC APL+P NT+ C I S+L YFQN+ ++L D+ HFLYC
Sbjct: 468 QDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCAN 527
Query: 519 APASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQ 578
AP + D + L C+ +G PVFP+L +GGY ++Y+ A AL++TF +NNY +L
Sbjct: 528 APLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLA 587
Query: 579 RAQAWEKEFINFVKNYKNPN---LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYI 635
+A+ WE+ F+ ++ ++ ++F AERS+EDE+NR + D+ SY ++FLYI
Sbjct: 588 QAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYI 647
Query: 636 SLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVL 695
SLALG S R++VDSK +LG+ G+ +VL +V ++G FSY+G+ +L++++V+PFLVL
Sbjct: 648 SLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVL 707
Query: 696 AVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMP 755
+VG DNIFI V YQR R GE + +GR LG VAPSM L S SE + FFLGAL+ MP
Sbjct: 708 SVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMP 767
Query: 756 AVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASES 815
AV TF+L +GLAV +DFLLQ++ FV+LL LD KRQE +RLD+ CCV+ E Q E
Sbjct: 768 AVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQ-GEG 826
Query: 816 CLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDY 875
L FF+ +Y+P LL R +V+ +F+ + S+ + + +GLDQ L++P DSY++DY
Sbjct: 827 LLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDY 886
Query: 876 FKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRI 935
F +++Y G PVYFV G++++S G N +C GCNN S Q+I A + + +
Sbjct: 887 FLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYL 946
Query: 936 GFAPSSWIDDYFDWVKPQSSCCRV---DNITDQFCNASVVDPACVR-CRPLTPEGKQRPQ 991
SSW+DD+ DW+ P SSCCR+ D+FC ++V C++ C +T G RP
Sbjct: 947 AIPASSWVDDFIDWLTP-SSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSIT-MGSVRPS 1004
Query: 992 GGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADF 1051
F ++LP FL+D PN KC KGG AAYS++VN L +V A+ FM YH L+ S D+
Sbjct: 1005 VEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVN--LTSDGQVLASRFMAYHKPLKNSQDY 1062
Query: 1052 IDALKKARLIASNVT-ETMGINGS--AYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGA 1108
+AL+ AR +A+N+T + + G+ A+ VFPY++ VFYEQYLTI+ + +F L + L
Sbjct: 1063 TEALRAARELAANITADLRKVPGTDPAFEVFPYTITNVFYEQYLTILPEGLFMLSLCLVP 1122
Query: 1109 IFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFC 1168
F V+ +LLG +L S ++ +I M+LV+ G M LWGIS NAVSL+NLV + G+SVEF
Sbjct: 1123 TFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMALWGISYNAVSLINLVSAVGMSVEFV 1182
Query: 1169 SHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRM 1228
SHITR+F +S K + +ERA+EA MGS+VF+G+ +T GI+VL AK+Q+ QIF+FR+
Sbjct: 1183 SHITRSFAISTKPTWLERAKEATISMGSAVFAGVAMTNLPGILVLGLAKAQLIQIFFFRL 1242
Query: 1229 YLAMVLLGATHGLIFLPVLLSYIGPSVNKA 1258
L + LLG HGL+FLPV+LSY+GP VN A
Sbjct: 1243 NLLITLLGLLHGLVFLPVILSYVGPDVNPA 1272
>gi|156231351 Niemann-Pick C1-like protein 1 isoform 1 [Homo sapiens]
Length = 1359
Score = 894 bits (2310), Expect = 0.0
Identities = 516/1315 (39%), Positives = 756/1315 (57%), Gaps = 82/1315 (6%)
Query: 4 RGLALGLLLLLLCPAQVFSQS-----CVWYGECG-------IAYGDKRYNCEYSGPPKPL 51
RG L LLL L ++ ++ C +Y ECG +C + P + +
Sbjct: 7 RGWLLWALLLRLAQSEPYTTIHQPGYCAFYDECGKNPELSGSLMTLSNVSCLSNTPARKI 66
Query: 52 PKDGYDLVQELCPGFFFG-NVSLCCDVRQLQTLKDNLQLPLQFLSRCPSCFYNLLNLFCE 110
D L+Q++CP + G N CC +QL +L+ +L + L+RCP+C N +NL C
Sbjct: 67 TGDHLILLQKICPRLYTGPNTQACCSAKQLVSLEASLSITKALLTRCPACSDNFVNLHCH 126
Query: 111 LTCSPRQSQFLNVTATEDYVDPVTNQTKTNVKELQYYVGQSFANAMYNACRDVEAPSSND 170
TCSP QS F+NVT V + V + + SFA Y++C V P++
Sbjct: 127 NTCSPNQSLFINVTR----VAQLGAGQLPAVVAYEAFYQHSFAEQSYDSCSRVRVPAAAT 182
Query: 171 KALGLLCGKDADA-CNATNWIEYMFNKDNGQAPFTITPVFSD---FPVHGMEPMNNATKG 226
A+G +CG A CNA W+ + + NG AP IT + G++P+N
Sbjct: 183 LAVGTMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQAVGSGIQPLNEGVAR 242
Query: 227 CDESVDEVTAPCSCQDCSIVCGPKPQPPPPPAPWTILGLDAMYVIMWITYMAFLLVFFGA 286
C+ES + A CSCQDC+ C +P LD+ + + + L++ +
Sbjct: 243 CNESQGDDVATCSCQDCAASCPAIARPQ---------ALDSTFYLGQMPGSLVLIIILCS 293
Query: 287 FFAVWCYRKRYFVSEYTPIDSNIAFSVNASDKGEASCCDPVSAAFEGCLRRLFTRWGSFC 346
FAV F P S K S D +S + L + F WG++
Sbjct: 294 VFAVVTILLVGF--RVAPARDK---SKMVDPKKGTSLSDKLSFSTHTLLGQFFQGWGTWV 348
Query: 347 VRNPGCVIFFSLVFITACSSGLVFVRVTTNPVDLWSAPSSQARLEKEYFDQHFGPFFRTE 406
P ++ S++ + A ++GLVF +TT+PV+LWSAP+SQAR EK + DQHFGPFFRT
Sbjct: 349 ASWPLTILVLSVIPVVALAAGLVFTELTTDPVELWSAPNSQARSEKAFHDQHFGPFFRTN 408
Query: 407 QLIIRAPLTDKHIYQPYPSGADVPFGPPLDIQILHQVLDLQIAIENIT--ASYDNETVTL 464
Q+I+ AP + Y G F LD+ +L ++L+LQ + ++ + ++L
Sbjct: 409 QVILTAPNRSSYRYDSLLLGPK-NFSGILDLDLLLELLELQERLRHLQVWSPEAQRNISL 467
Query: 465 QDICLAPLSPYNTN---CTILSVLNYFQNSHSVLDHKKGDDFF---VYADYHTHFLYCVR 518
QDIC APL+P NT+ C I S+L YFQN+ ++L D+ HFLYC
Sbjct: 468 QDICYAPLNPDNTSLYDCCINSLLQYFQNNRTLLLLTANQTLMGQTSQVDWKDHFLYCAN 527
Query: 519 APASLNDTSLLHDPCLGTFGGPVFPWLVLGGYDDQNYNNATALVITFPVNNYYNDTEKLQ 578
AP + D + L C+ +G PVFP+L +GGY ++Y+ A AL++TF +NNY +L
Sbjct: 528 APLTFKDGTALALSCMADYGAPVFPFLAIGGYKGKDYSEAEALIMTFSLNNYPAGDPRLA 587
Query: 579 RAQAWEKEFINFVKNYKNPN---LTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYI 635
+A+ WE+ F+ ++ ++ ++F AERS+EDE+NR + D+ SY ++FLYI
Sbjct: 588 QAKLWEEAFLEEMRAFQRRMAGMFQVTFMAERSLEDEINRTTAEDLPIFATSYIVIFLYI 647
Query: 636 SLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVL 695
SLALG S R++VDSK +LG+ G+ +VL +V ++G FSY+G+ +L++++V+PFLVL
Sbjct: 648 SLALGSYSSWSRVMVDSKATLGLGGVAVVLGAVMAAMGFFSYLGIRSSLVILQVVPFLVL 707
Query: 696 AVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMP 755
+VG DNIFI V YQR R GE + +GR LG VAPSM L S SE + FFLGAL+ MP
Sbjct: 708 SVGADNIFIFVLEYQRLPRRPGEPREVHIGRALGRVAPSMLLCSLSEAICFFLGALTPMP 767
Query: 756 AVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASES 815
AV TF+L +GLAV +DFLLQ++ FV+LL LD KRQE +RLD+ CCV+ E Q E
Sbjct: 768 AVRTFALTSGLAVILDFLLQMSAFVALLSLDSKRQEASRLDVCCCVKPQELPPPGQG-EG 826
Query: 816 CLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDY 875
L FF+ +Y+P LL R +V+ +F+ + S+ + + +GLDQ L++P DSY++DY
Sbjct: 827 LLLGFFQKAYAPFLLHWITRGVVLLLFLALFGVSLYSMCHISVGLDQELALPKDSYLLDY 886
Query: 876 FKSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRI 935
F +++Y G PVYFV G++++S G N +C GCNN S Q+I A + + +
Sbjct: 887 FLFLNRYFEVGAPVYFVTTLGYNFSSEAGMNAICSSAGCNNFSFTQKIQYATEFPEQSYL 946
Query: 936 GFAPSSWIDDYFDWVKPQSSCCRV---DNITDQFCNASVVDPACVR-CRPLTPEGKQRPQ 991
SSW+DD+ DW+ P SSCCR+ D+FC ++V C++ C +T G RP
Sbjct: 947 AIPASSWVDDFIDWLTP-SSCCRLYISGPNKDKFCPSTVNSLNCLKNCMSITM-GSVRPS 1004
Query: 992 GGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNIL---------------LGHGTRVGA- 1035
F ++LP FL+D PN KC KGG AAYS++VN+ L + + A
Sbjct: 1005 VEQFHKYLPWFLNDRPNIKCPKGGLAAYSTSVNLTSDGQVLDTVAILSPRLEYSGTISAH 1064
Query: 1036 ---------TYFMTYHTVLQTSADFIDALKKARLIASNVTETMG-INGS--AYRVFPYSV 1083
+ FM YH L+ S D+ +AL+ AR +A+N+T + + G+ A+ VFPY++
Sbjct: 1065 CNLYLLDSTSRFMAYHKPLKNSQDYTEALRAARELAANITADLRKVPGTDPAFEVFPYTI 1124
Query: 1084 FYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMW 1143
VFYEQYLTI+ + +F L + L F V+ +LLG +L S ++ +I M+LV+ G M
Sbjct: 1125 TNVFYEQYLTILPEGLFMLSLCLVPTFAVSCLLLGLDLRSGLLNLLSIVMILVDTVGFMA 1184
Query: 1144 LWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGIT 1203
LWGIS NAVSL+NLV + G+SVEF SHITR+F +S K + +ERA+EA MGS+VF+G+
Sbjct: 1185 LWGISYNAVSLINLVSAVGMSVEFVSHITRSFAISTKPTWLERAKEATISMGSAVFAGVA 1244
Query: 1204 LTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKA 1258
+T GI+VL AK+Q+ QIF+FR+ L + LLG HGL+FLPV+LSY+GP VN A
Sbjct: 1245 MTNLPGILVLGLAKAQLIQIFFFRLNLLITLLGLLHGLVFLPVILSYVGPDVNPA 1299
>gi|134254450 patched isoform S [Homo sapiens]
Length = 1296
Score = 130 bits (328), Expect = 6e-30
Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)
Query: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876
L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936
+ +Y + +Y V ++ DY N L+ + + Y +
Sbjct: 641 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 684
Query: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986
P W+ + DW++ D T + + N S D + + L G
Sbjct: 685 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 742
Query: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017
KQR D F +L ++S++P P + H A
Sbjct: 743 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 802
Query: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077
Y + + + F Y L+ ++DF++A++K R I SN T ++G++
Sbjct: 803 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 857
Query: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137
+P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V
Sbjct: 858 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 915
Query: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197
+FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM +
Sbjct: 916 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 974
Query: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP
Sbjct: 975 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
Score = 130 bits (326), Expect = 1e-29
Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)
Query: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627
+N+ + +AW++ ++ V N T +SFT +++D L SD V V
Sbjct: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 294
Query: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687
Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+
Sbjct: 295 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 349
Query: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747
+V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF
Sbjct: 350 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 409
Query: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
+ AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC
Sbjct: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
>gi|134254435 patched isoform S [Homo sapiens]
Length = 1296
Score = 130 bits (328), Expect = 6e-30
Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)
Query: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876
L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936
+ +Y + +Y V ++ DY N L+ + + Y +
Sbjct: 641 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 684
Query: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986
P W+ + DW++ D T + + N S D + + L G
Sbjct: 685 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 742
Query: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017
KQR D F +L ++S++P P + H A
Sbjct: 743 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 802
Query: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077
Y + + + F Y L+ ++DF++A++K R I SN T ++G++
Sbjct: 803 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 857
Query: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137
+P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V
Sbjct: 858 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 915
Query: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197
+FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM +
Sbjct: 916 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 974
Query: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP
Sbjct: 975 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
Score = 130 bits (326), Expect = 1e-29
Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)
Query: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627
+N+ + +AW++ ++ V N T +SFT +++D L SD V V
Sbjct: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 294
Query: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687
Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+
Sbjct: 295 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 349
Query: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747
+V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF
Sbjct: 350 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 409
Query: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
+ AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC
Sbjct: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
>gi|134254468 patched isoform S [Homo sapiens]
Length = 1296
Score = 130 bits (328), Expect = 6e-30
Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)
Query: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876
L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936
+ +Y + +Y V ++ DY N L+ + + Y +
Sbjct: 641 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 684
Query: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986
P W+ + DW++ D T + + N S D + + L G
Sbjct: 685 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 742
Query: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017
KQR D F +L ++S++P P + H A
Sbjct: 743 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 802
Query: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077
Y + + + F Y L+ ++DF++A++K R I SN T ++G++
Sbjct: 803 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 857
Query: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137
+P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V
Sbjct: 858 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 915
Query: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197
+FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM +
Sbjct: 916 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 974
Query: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP
Sbjct: 975 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
Score = 130 bits (326), Expect = 1e-29
Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)
Query: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627
+N+ + +AW++ ++ V N T +SFT +++D L SD V V
Sbjct: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 294
Query: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687
Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+
Sbjct: 295 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 349
Query: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747
+V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF
Sbjct: 350 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 409
Query: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
+ AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC
Sbjct: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
>gi|134254452 patched isoform S [Homo sapiens]
Length = 1296
Score = 130 bits (328), Expect = 6e-30
Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)
Query: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876
L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+
Sbjct: 581 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 640
Query: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936
+ +Y + +Y V ++ DY N L+ + + Y +
Sbjct: 641 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 684
Query: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986
P W+ + DW++ D T + + N S D + + L G
Sbjct: 685 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 742
Query: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017
KQR D F +L ++S++P P + H A
Sbjct: 743 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 802
Query: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077
Y + + + F Y L+ ++DF++A++K R I SN T ++G++
Sbjct: 803 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 857
Query: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137
+P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V
Sbjct: 858 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 915
Query: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197
+FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM +
Sbjct: 916 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 974
Query: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP
Sbjct: 975 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1029
Score = 130 bits (326), Expect = 1e-29
Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)
Query: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627
+N+ + +AW++ ++ V N T +SFT +++D L SD V V
Sbjct: 236 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 294
Query: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687
Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+
Sbjct: 295 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 349
Query: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747
+V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF
Sbjct: 350 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 409
Query: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
+ AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC
Sbjct: 410 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 462
>gi|134254432 patched isoform L' [Homo sapiens]
Length = 1446
Score = 130 bits (328), Expect = 6e-30
Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)
Query: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876
L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+
Sbjct: 731 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 790
Query: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936
+ +Y + +Y V ++ DY N L+ + + Y +
Sbjct: 791 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 834
Query: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986
P W+ + DW++ D T + + N S D + + L G
Sbjct: 835 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 892
Query: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017
KQR D F +L ++S++P P + H A
Sbjct: 893 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 952
Query: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077
Y + + + F Y L+ ++DF++A++K R I SN T ++G++
Sbjct: 953 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 1007
Query: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137
+P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V
Sbjct: 1008 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 1065
Query: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197
+FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM +
Sbjct: 1066 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 1124
Query: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP
Sbjct: 1125 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1179
Score = 130 bits (326), Expect = 1e-29
Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)
Query: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627
+N+ + +AW++ ++ V N T +SFT +++D L SD V V
Sbjct: 386 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 444
Query: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687
Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+
Sbjct: 445 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 499
Query: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747
+V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF
Sbjct: 500 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 559
Query: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
+ AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC
Sbjct: 560 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 612
>gi|134254466 patched isoform M [Homo sapiens]
Length = 1381
Score = 130 bits (328), Expect = 6e-30
Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)
Query: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876
L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+
Sbjct: 666 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 725
Query: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936
+ +Y + +Y V ++ DY N L+ + + Y +
Sbjct: 726 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 769
Query: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986
P W+ + DW++ D T + + N S D + + L G
Sbjct: 770 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 827
Query: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017
KQR D F +L ++S++P P + H A
Sbjct: 828 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 887
Query: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077
Y + + + F Y L+ ++DF++A++K R I SN T ++G++
Sbjct: 888 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 942
Query: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137
+P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V
Sbjct: 943 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 1000
Query: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197
+FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM +
Sbjct: 1001 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 1059
Query: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP
Sbjct: 1060 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1114
Score = 130 bits (326), Expect = 1e-29
Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)
Query: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627
+N+ + +AW++ ++ V N T +SFT +++D L SD V V
Sbjct: 321 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 379
Query: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687
Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+
Sbjct: 380 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 434
Query: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747
+V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF
Sbjct: 435 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 494
Query: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
+ AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC
Sbjct: 495 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 547
>gi|134254446 patched isoform L [Homo sapiens]
Length = 1447
Score = 130 bits (328), Expect = 6e-30
Identities = 126/476 (26%), Positives = 214/476 (44%), Gaps = 66/476 (13%)
Query: 817 LFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYF 876
L F + Y+P LLK + +VI +F+G+L S+ +V GLD + +P ++ D+
Sbjct: 732 LSSFAEKHYAPFLLKPKAKVVVIFLFLGLLGVSLYGTTRVRDGLDLTDIVPRETREYDFI 791
Query: 877 KSISQYLHAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRIG 936
+ +Y + +Y V ++ DY N L+ + + Y +
Sbjct: 792 AAQFKYF-SFYNMYIVTQKA-DYP--------------NIQHLLYDLHRSFSNVKYVMLE 835
Query: 937 F---APSSWIDDYFDWVKPQSSCCRVDNIT-----DQFCNASVVDPACVRCRPLTPEG-- 986
P W+ + DW++ D T + + N S D + + L G
Sbjct: 836 ENKQLPKMWLHYFRDWLQGLQDAFDSDWETGKIMPNNYKNGS--DDGVLAYKLLVQTGSR 893
Query: 987 ----------KQRPQGGD-------FMRFLPMFLSDNP----------NPKCGKGGH--A 1017
KQR D F +L ++S++P P + H A
Sbjct: 894 DKPIDISQLTKQRLVDADGIINPSAFYIYLTAWVSNDPVAYAASQANIRPHRPEWVHDKA 953
Query: 1018 AYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIASNVTETMGINGSAYR 1077
Y + + + F Y L+ ++DF++A++K R I SN T ++G++
Sbjct: 954 DYMPETRLRIPAAEPIEYAQFPFYLNGLRDTSDFVEAIEKVRTICSNYT-SLGLSS---- 1008
Query: 1078 VFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVN 1137
+P ++F+EQY+ + + + V L FLV V L W+A I+ +A++ V
Sbjct: 1009 -YPNGYPFLFWEQYIGLRHWLLLFISVVLACTFLVCAVFL-LNPWTAGIIVMVLALMTVE 1066
Query: 1138 MFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSS 1197
+FG+M L GI L+AV +V L+ S GI VEF H+ AF ++ G + RA AL HM +
Sbjct: 1067 LFGMMGLIGIKLSAVPVVILIASVGIGVEFTVHVALAFLTAI-GDKNRRAVLALEHMFAP 1125
Query: 1198 VFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
V G T G+++LA ++ ++F + + +LG +GL+ LPVLLS+ GP
Sbjct: 1126 VLDGAVSTLL-GVLMLAGSEFDFIVRYFFAVLAILTILGVLNGLVLLPVLLSFFGP 1180
Score = 130 bits (326), Expect = 1e-29
Identities = 77/233 (33%), Positives = 123/233 (52%), Gaps = 9/233 (3%)
Query: 571 YNDTEKLQRAQAWEKEFINFVKNYKNPNLT---ISFTAERSIEDELNRESDSDVFTVVIS 627
+N+ + +AW++ ++ V N T +SFT +++D L SD V V
Sbjct: 387 WNEDKAAAILEAWQRTYVEVVHQSVAQNSTQKVLSFTTT-TLDDILKSFSDVSVIRVASG 445
Query: 628 YAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVI 687
Y +M Y L + R S+ ++G+AG+L+V SVA LG+ S IG+
Sbjct: 446 YLLMLAYACLTM-----LRWDCSKSQGAVGLAGVLLVALSVAAGLGLCSLIGISFNAATT 500
Query: 688 EVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFF 747
+V+PFL L VGVD++F+L A+ + + + + G L S+ L+S S AFF
Sbjct: 501 QVLPFLALGVGVDDVFLLAHAFSETGQNKRIPFEDRTGECLKRTGASVALTSISNVTAFF 560
Query: 748 LGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
+ AL +PA+ FSL A + V +F + + F ++L +D+ R+E RLDIFCC
Sbjct: 561 MAALIPIPALRAFSLQAAVVVVFNFAMVLLIFPAILSMDLYRREDRRLDIFCC 613
>gi|52145305 patched 2 [Homo sapiens]
Length = 1203
Score = 120 bits (302), Expect = 6e-27
Identities = 69/222 (31%), Positives = 119/222 (53%), Gaps = 9/222 (4%)
Query: 581 QAWEKEFINFVKNY--KNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLA 638
QAW++ F+ + +N + I + +++D L+ S+ VV Y +M Y +
Sbjct: 353 QAWQRRFVQLAQEALPENASQQIHAFSSTTLDDILHAFSEVSAARVVGGYLLMLAYACVT 412
Query: 639 LGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVG 698
+ R S+ S+G+AG+L+V +VA LG+ + +G+ +V+PFL L +G
Sbjct: 413 M-----LRWDCAQSQGSVGLAGVLLVALAVASGLGLCALLGITFNAATTQVLPFLALGIG 467
Query: 699 VDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVH 758
VD++F+L A+ E L G L +++G L S+ L+S + AF + AL +PA+
Sbjct: 468 VDDVFLLAHAFT--EALPGTPLQERMGECLQRTGTSVVLTSINNMAAFLMAALVPIPALR 525
Query: 759 TFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCC 800
FSL A + V F+ + F ++L LD++R+ RLD+ CC
Sbjct: 526 AFSLQAAIVVGCTFVAVMLVFPAILSLDLRRRHCQRLDVLCC 567
Score = 111 bits (277), Expect = 5e-24
Identities = 72/209 (34%), Positives = 113/209 (54%), Gaps = 9/209 (4%)
Query: 1045 LQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGV 1104
LQ +ADF++A++ AR + + + +P ++F+EQYL + + + +
Sbjct: 917 LQKTADFVEAIEGARAACAEAGQ------AGVHAYPSGSPFLFWEQYLGLRRCFLLAVCI 970
Query: 1105 SLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGIS 1164
L FLV +LL W+A ++ +AM+ V +FG+M GI L+A+ +V LV S GI
Sbjct: 971 LLVCTFLVCALLL-LNPWTAGLIVLVLAMMTVELFGIMGFLGIKLSAIPVVILVASVGIG 1029
Query: 1165 VEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIF 1224
VEF H+ F ++ +GSR RA AL H + V G T G+++LA + +
Sbjct: 1030 VEFTVHVALGF-LTTQGSRNLRAAHALEHTFAPVTDGAISTLL-GLLMLAGSHFDFIVRY 1087
Query: 1225 YFRMYLAMVLLGATHGLIFLPVLLSYIGP 1253
+F + LLG HGL+ LPVLLS +GP
Sbjct: 1088 FFAALTVLTLLGLLHGLVLLPVLLSILGP 1116
>gi|194018513 patched domain containing 3 [Homo sapiens]
Length = 767
Score = 108 bits (270), Expect = 3e-23
Identities = 88/355 (24%), Positives = 159/355 (44%), Gaps = 38/355 (10%)
Query: 570 YYNDTEKLQ---RAQAWEKEFINFVKNYKNPNLTISFTAERSIE----DELNRESDSDVF 622
YY TE + +++ W ++ N KN A + IE L+R+ + +
Sbjct: 326 YYLKTEDPEYDVQSKQWLTHLLDQFTNIKN------ILALKKIEVVHFTSLSRQLEFEAT 379
Query: 623 TVVISYAIMFLYISLALGHIKSCRRL-LVDSKVSLGIAGILIVLSSVACSLGVFSYIGLP 681
+V + YI + L + SC R + +K+ + G++ +V G+ +IG+P
Sbjct: 380 SVTVIPVFHLAYILIILFAVTSCFRFDCIRNKMCVAAFGVISAFLAVVSGFGLLLHIGVP 439
Query: 682 LTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFS 741
+IV PFL+L VGVD++FI++ A+ + + + +++ V + A S+ +++ +
Sbjct: 440 FVIIVANS-PFLILGVGVDDMFIMISAWHKTNL--ADDIRERMSNVYSKAAVSITITTIT 496
Query: 742 ETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQ----------- 790
+A + G +S +V F ++ G+ + + ITCF + + LD KR+
Sbjct: 497 NILALYTGIMSSFRSVQCFCIYTGMTLLFCYFYNITCFGAFMALDGKREVVCLCWLKKAD 556
Query: 791 -EKNRLDIFCCVRGA----EDGTSVQASESCLFRFFKNSYSPLLLKDWMRPIVIAIFVGV 845
+ FCC E GT + + FF++ + P L + + V+ I+V
Sbjct: 557 PKWPSFKKFCCFPFGSVPDEHGTDIHP----ISLFFRDYFGPFLTRSESKYFVVFIYVLY 612
Query: 846 LSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL-HAGPPVYFVLEEGHDY 899
+ SI V GLD DDSY+ YF Y GP V ++ + DY
Sbjct: 613 IISSIYGCFHVQEGLDLRNLASDDSYITPYFNVEENYFSDYGPRVMVIVTKKVDY 667
>gi|148277106 hypothetical protein LOC442213 [Homo sapiens]
Length = 829
Score = 101 bits (251), Expect = 5e-21
Identities = 141/756 (18%), Positives = 307/756 (40%), Gaps = 120/756 (15%)
Query: 552 DQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNYKNPN--LTISFTAERSI 609
DQ +A A+ IT+ + Y + T+ L + WE EF ++ + + L + A S+
Sbjct: 147 DQRVKSARAIQITYYLQTYGSATQDLI-GEKWENEFCKLIRKLQEEHQELQLYSLASFSL 205
Query: 610 EDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVA 669
+ ++ S V++S ++ +L+ +K C R SK LG+ G+L V S+
Sbjct: 206 WRDFHKTSILARSKVLVSLVLILTTATLS-SSMKDCLR----SKPFLGLLGVLTVCISII 260
Query: 670 CSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLG 729
+ G+F ++ IPF + G +F L+ ++R + + ++
Sbjct: 261 TAAGIFFITDGKYNSTLLG-IPFFAMGHGTKGVFELLSGWRRTK--ENLPFKDRIADAYS 317
Query: 730 EVAPSMFLSSFSETVAFFLGA--LSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDI 787
+V + ++S + F +GA + + AV F +++ +++ + F S L
Sbjct: 318 DVMVTYTMTSSLYFITFGMGASPFTNIEAVKVFCQNMCVSILLNYFYIFSFFGSCLVFAG 377
Query: 788 KRQEKNRLDIFCC-VRGAE--------------DGTSVQASESC-------LFRFFKNSY 825
+ ++ IFCC + AE DG + + F + Y
Sbjct: 378 QLEQNRYHSIFCCKIPSAEYLDRKPVWFQTVMSDGHQQTSHHETNPYQHHFIQHFLREHY 437
Query: 826 SPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLSMPDDSYMVDYFKSISQYL-H 884
+ + +++P V+ +++ SFS ++ G + + DS V Y +Y +
Sbjct: 438 NEWITNIYVKPFVVILYLIYASFSFMGCLQISDGANIINLLASDSPSVSYAMVQQKYFSN 497
Query: 885 AGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIFNAAQLDNYTRI--GFAPSSW 942
P + F + E +Y +N++ D+ R+ GF SW
Sbjct: 498 YSPVIGFYVYEPLEY------------------------WNSSVQDDLRRLCSGFTAVSW 533
Query: 943 IDDYFDWVKPQSSCCRVDNITDQFCNASVVDPACVRCRPLTPEGKQRPQGGDFMRFLPMF 1002
++ Y+ ++K S +N +D SV+ + ++ PE + F
Sbjct: 534 VEQYYQFLK--VSNVSANNKSDFI---SVLQSSFLK----KPEFQH-------------F 571
Query: 1003 LSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYHTVLQTSADFIDALKKARLIA 1062
+D K G + + + ++ T + + L+K R ++
Sbjct: 572 RNDIIFSKAGDESNI---------------IASRLYLVARTSRDKQKEITEVLEKLRPLS 616
Query: 1063 SNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELW 1122
+ + R ++ +VF + Y + + G + + ++T L+ L
Sbjct: 617 LS---------KSIRFIVFNPSFVFMDHYSLSVTVPVLIAGFGVLLVLILTFFLVIHPLG 667
Query: 1123 SAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGS 1182
+ ++ ++ + + + G+M LW + ++ +S++ L+ + +++ C+ + F ++ + +
Sbjct: 668 NFWLI-LSVTSIELGVLGLMTLWNVDMDCISILCLIYTLNFAIDHCAPLLFTFVLATEHT 726
Query: 1183 RVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGA---TH 1239
R + + +L G+++ +T + G+V L F S + F ++ ++L G H
Sbjct: 727 RTQCIKSSLQDHGTAILQNVT-SFLIGLVPLLFVPSNL----TFTLFKCLLLTGGCTLLH 781
Query: 1240 GLIFLPVLLSYIGPSVNKAKSCATEERYKGTERERL 1275
+ LPV L++ PS K ++R K ERE +
Sbjct: 782 CFVILPVFLTFFPPSKKHHKK---KKRAKRKEREEI 814
>gi|148271104 patched domain containing 1 [Homo sapiens]
Length = 888
Score = 88.2 bits (217), Expect = 5e-17
Identities = 143/770 (18%), Positives = 302/770 (39%), Gaps = 119/770 (15%)
Query: 538 GGPVFPWLVLGG---YDDQNYNNATALVITFPVNNYYNDTEKLQRAQAWEKEFINFVKNY 594
G V+ LGG + +A A+ +T+ + + + + + A+ WE F + V+ +
Sbjct: 183 GRAVYNGHQLGGVTVHSKDRVKSAEAIQLTYYLQSINSLNDMV--AERWESSFCDTVRLF 240
Query: 595 KNPNLTIS---FTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVD 651
+ N + +T+ ED S+ + +++ I+ + +++ ++ C R
Sbjct: 241 QKSNSKVKMYPYTSSSLREDFQKTSRVSERY--LVTSLILVVTMAILCCSMQDCVR---- 294
Query: 652 SKVSLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQR 711
SK LG+ G++ + + + G+ + G + V PF++L G+ F ++ ++++
Sbjct: 295 SKPWLGLLGLVTISLATLTAAGIINLTGGKYNSTFLGV-PFVMLGHGLYGTFEMLSSWRK 353
Query: 712 DERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGA--LSVMPAVHTFSLFAGLAVF 769
+ + + ++ V + S L++ V F +GA + + A F + +A+F
Sbjct: 354 TR--EDQHVKERTAAVYADSMLSFSLTTAMYLVTFGIGASPFTNIEAARIFCCNSCIAIF 411
Query: 770 IDFLLQITCFVSLLGLDIKRQEKNRLDIFC--------------------CVRGAED--- 806
++L ++ + S L + + IFC R +ED
Sbjct: 412 FNYLYVLSFYGSSLVFTGYIENNYQHSIFCRKVPKPEALQEKPAWYRFLLTARFSEDTAE 471
Query: 807 GTSVQASES-CLFRFFKNSYSPLLLKDWMRPIVIAIFVGVLSFSIAVLNKVDIGLDQSLS 865
G ES L F K Y + +++P V+ ++ +SF++ +V G D S
Sbjct: 472 GEEANTYESHLLVCFLKRYYCDWITNTYVKPFVVLFYLIYISFALMGYLQVSEGSDLSNI 531
Query: 866 MPDDSYMVDYFKSISQYL-HAGPPVYFVLEEGHDYTSSKGQNMVCGGMGCNNDSLVQQIF 924
+ + ++Y + +Y + P + F + E +Y ++ Q V
Sbjct: 532 VATATQTIEYTTAQQKYFSNYSPVIGFYIYESIEYWNTSVQEDVL--------------- 576
Query: 925 NAAQLDNYTRIGFAPSSWIDDYFDWVKP--QSSCCRVDNITDQFCNASVVDPACVRCRPL 982
YT+ GF SW + Y ++++ S+ N TD N+ +
Sbjct: 577 ------EYTK-GFVRISWFESYLNYLRKLNVSTGLPKKNFTDMLRNSFL----------- 618
Query: 983 TPEGKQRPQGGDFMRFLPMFLSDNPNPKCGKGGHAAYSSAVNILLGHGTRVGATYFMTYH 1042
+ PQ F + Y+ V++ V + F+
Sbjct: 619 -----KAPQFSHFQEDIIF--------------SKKYNDEVDV-------VASRMFLVAK 652
Query: 1043 TVLQTSADFIDALKKARLIASNVTETMGINGSAYRVFPYSVFYVFYEQYLTIIDDTIFNL 1102
T+ + D L+ R ++ S + ++ +V+ ++Y + + + N
Sbjct: 653 TMETNREELYDLLETLRRLSVT---------SKVKFIVFNPSFVYMDRYASSLGAPLHNS 703
Query: 1103 GVSLGAIFLVTM-VLLGCELWSAVIMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSC 1161
+S A+FL+ L + V + T+ V + G M LW + L+ +S++ L+
Sbjct: 704 CIS--ALFLLFFSAFLVADSLINVWITLTVVSVEFGVIGFMTLWKVELDCISVLCLIYGI 761
Query: 1162 GISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSGITLTKFGGIVVLAFAKSQIF 1221
+++ C+ + F + +R + + AL G ++ L G++ LA S +
Sbjct: 762 NYTIDNCAPMLSTFVLGKDFTRTKWVKNALEVHGVAILQSY-LCYIVGLIPLAAVPSNL- 819
Query: 1222 QIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAKSCATEERYKGTE 1271
FR + + H LPV+L+++ PS K K E + E
Sbjct: 820 TCTLFRCLFLIAFVTFFHCFAILPVILTFLPPSKKKRKEKKNPENREEIE 869
>gi|66932902 SREBF chaperone protein [Homo sapiens]
Length = 1279
Score = 81.3 bits (199), Expect = 6e-15
Identities = 54/197 (27%), Positives = 102/197 (51%), Gaps = 8/197 (4%)
Query: 596 NPNLTISFTAERSIEDELNRESD-SDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKV 654
+P+ S AE + E +++ +V +Y I+F YI + I +V SK
Sbjct: 259 HPSPNCSLRAESLVHVHFKEEIGVAELIPLVTTYIILFAYIYFSTRKID-----MVKSKW 313
Query: 655 SLGIAGILIVLSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDER 714
L +A ++ VLSS+ S+G+ + GL TL E+ P+LV+ +G++N+ +L ++
Sbjct: 314 GLALAAVVTVLSSLLMSVGLCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTP- 372
Query: 715 LQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLL 774
+ ++ + L + S+ + +E +G +++PA+ F LFA + + DF L
Sbjct: 373 -VDLEVKLRIAQGLSSESWSIMKNMATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFL 431
Query: 775 QITCFVSLLGLDIKRQE 791
Q+ F ++L +DI+R E
Sbjct: 432 QMLFFTTVLSIDIRRME 448
>gi|149274653 patched domain containing 2 [Homo sapiens]
Length = 1392
Score = 63.5 bits (153), Expect = 1e-09
Identities = 56/256 (21%), Positives = 110/256 (42%), Gaps = 25/256 (9%)
Query: 540 PVFPWLVLGGYDDQNYNNA---TALVITFPVNNYYN--DTEKLQRA--QAWEKEFINFVK 592
P F W V G N ++ + ++ P+ NYY+ D + QRA Q++ ++ +
Sbjct: 375 PEFYWYVDEGLSADNLKSSLLRSEILFGAPLPNYYSVDDRWEEQRAKFQSFVVTYVAMLA 434
Query: 593 NYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLLVDS 652
+ + + + E+ R ++D+ IS + + + + L
Sbjct: 435 KQSTSKVQVLYGGTDLFDYEVRRTFNNDMLLAFISSSCIAALVYI-----------LTSC 483
Query: 653 KVSLGIAGILIVLSSVACSLGVFSY---IGLPLTLIVIEVIPFLVLAVGVDNIFILVQAY 709
V L GI + ++C + +F Y G+ I+ V F+++ +GVD++F+ + Y
Sbjct: 484 SVFLSFFGIASI--GLSCLVALFLYHVVFGIQYLGILNGVAAFVIVGIGVDDVFVFINTY 541
Query: 710 QRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFAGLAVF 769
++ L+ L ++ + + F +S + A+ S +PAVH F LF L V
Sbjct: 542 RQATHLEDPQL--RMIHTVQTAGKATFFTSLTTAAAYAANVFSQIPAVHDFGLFMSLIVS 599
Query: 770 IDFLLQITCFVSLLGL 785
+L + + LGL
Sbjct: 600 CCWLAVLVTMPAALGL 615
Score = 33.5 bits (75), Expect = 1.3
Identities = 30/131 (22%), Positives = 58/131 (44%), Gaps = 25/131 (19%)
Query: 1104 VSLGAIFLVTMVLLGCELWSAV-IMCATIAMVLVNMFGVMWLWGISLNAVSLVNLVMSCG 1162
V+ A+F ++LL L S + I+C + +M+ G + AV ++L + G
Sbjct: 1195 VAAVAVFTTHILLLLPVLLSILGIVCLVVT--------IMYWSGWEMGAVEAISLSILVG 1246
Query: 1163 ISVEFCSHITRAFTVSMKGSRVERAE-----------EALAHMGSSVFSGITLTKFGGI- 1210
SV++C H+ + ++ + +AE EA+ H+G ++ S T +
Sbjct: 1247 SSVDYCVHLVEGYLLAGENLPPHQAEDARTQRQWRTLEAVRHVGVAIVSSALTTVIATVP 1306
Query: 1211 ----VVLAFAK 1217
++ FAK
Sbjct: 1307 LFFCIIAPFAK 1317
>gi|25952134 dispatched A [Homo sapiens]
Length = 1524
Score = 57.4 bits (137), Expect = 9e-08
Identities = 52/232 (22%), Positives = 105/232 (45%), Gaps = 21/232 (9%)
Query: 590 FVKNYKNPNLTISFTAERSIEDELNRESDSDVFTVVISYAIMFLYISLALGHIKSCRRLL 649
++ N++N N + T IE + D + Y + + I L + + + + +
Sbjct: 468 YLDNFENWNSSDGVTTITGIEFGIKHSLFQDYLLMDTVYPAIAIVIVLLVMCVYT-KSMF 526
Query: 650 VDSKVSLGIAGILIV---LSSVACSLGVFSYIGLPLTLIVIEVIPFLVLAVGVDNIFIL- 705
+ I LIV L V F ++ L +I++ +G D+ F+L
Sbjct: 527 ITLMTMFAIISSLIVSYFLYRVVFHFEFFPFMNLTALIILV--------GIGADDAFVLC 578
Query: 706 -VQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSSFSETVAFFLGALSVMPAVHTFSLFA 764
V Y + ++ ET + + L A SMF++SF+ AF+ +S + A+ F ++A
Sbjct: 579 DVWNYTKFDKPHAET-SETVSITLQHAALSMFVTSFTTAAAFYANYVSNITAIRCFGVYA 637
Query: 765 GLAVFIDFLLQITCFVSLLGLDIKRQEKNRLDIFCCVRGAEDGTSVQASESC 816
G A+ ++++L +T +++ L E+ L+IF C + + + ++SC
Sbjct: 638 GTAILVNYVLMVTWLPAVVVL----HERYLLNIFTCFKKPQQ--QIYDNKSC 683
Score = 45.4 bits (106), Expect = 3e-04
Identities = 40/178 (22%), Positives = 76/178 (42%), Gaps = 23/178 (12%)
Query: 1087 FYEQYLTIIDDTIFNLGVSLGAIFLVTMVLLGCELWSAVIMCATIAMVLVNMF---GVMW 1143
FY+ ++ D T+ +G+S+ F V ++ W+ +I I + +F G +
Sbjct: 973 FYDLQDSLSDGTLIAMGLSVAVAFSVMLLTT----WNIIISLYAIISIAGTIFVTVGSLV 1028
Query: 1144 LWGISLNAVSLVNLVMSCGISVEFCSHITRAFTVSMKGSRVERAEEALAHMGSSVFSG-- 1201
L G LN + V + ++ G+SV+F H A+ ++ R + +L+ +GS++
Sbjct: 1029 LLGWELNVLESVTISVAVGLSVDFAVHYGVAYRLAPDPDREGKVIFSLSRVGSAMAMAAL 1088
Query: 1202 --------------ITLTKFGGIVVLAFAKSQIFQIFYFRMYLAMVLLGATHGLIFLP 1245
+ T+ G ++L S F F+F+ + T G I LP
Sbjct: 1089 TTFVAGAMMMPSTVLAYTQLGTFMMLIMCISWAFATFFFQCMCRCLGPQGTCGQIPLP 1146
>gi|196049380 3-hydroxy-3-methylglutaryl-Coenzyme A reductase
isoform 2 [Homo sapiens]
Length = 835
Score = 48.9 bits (115), Expect = 3e-05
Identities = 39/176 (22%), Positives = 81/176 (46%), Gaps = 8/176 (4%)
Query: 619 SDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYI 678
SD+ + I+ I LYI +++ + SK LGIAG+ + SS S V ++
Sbjct: 60 SDIIILTITRCIAILYIYFQFQNLRQ-----LGSKYILGIAGLFTIFSSFVFSTVVIHFL 114
Query: 679 GLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLS 738
LT + E +PF +L + + L + + Q E + + + R + + P+ L
Sbjct: 115 DKELTGL-NEALPFFLLLIDLSRASTLAK-FALSSNSQDE-VRENIARGMAILGPTFTLD 171
Query: 739 SFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNR 794
+ E + +G +S + + F ++V ++ + +T F + + L ++ ++R
Sbjct: 172 ALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESR 227
>gi|4557643 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform
1 [Homo sapiens]
Length = 888
Score = 48.9 bits (115), Expect = 3e-05
Identities = 39/176 (22%), Positives = 81/176 (46%), Gaps = 8/176 (4%)
Query: 619 SDVFTVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIVLSSVACSLGVFSYI 678
SD+ + I+ I LYI +++ + SK LGIAG+ + SS S V ++
Sbjct: 60 SDIIILTITRCIAILYIYFQFQNLRQ-----LGSKYILGIAGLFTIFSSFVFSTVVIHFL 114
Query: 679 GLPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLS 738
LT + E +PF +L + + L + + Q E + + + R + + P+ L
Sbjct: 115 DKELTGL-NEALPFFLLLIDLSRASTLAK-FALSSNSQDE-VRENIARGMAILGPTFTLD 171
Query: 739 SFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKRQEKNR 794
+ E + +G +S + + F ++V ++ + +T F + + L ++ ++R
Sbjct: 172 ALVECLVIGVGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESR 227
>gi|25121980 dispatched B [Homo sapiens]
Length = 1401
Score = 46.2 bits (108), Expect = 2e-04
Identities = 41/158 (25%), Positives = 72/158 (45%), Gaps = 16/158 (10%)
Query: 623 TVVISYAIMFLYISLALGHIKSCRRLLVDSKVSLGIAGILIV---LSSVACSLGVFSYIG 679
TV A++ ++ +AL R L + V LG+ G L+V L VA + F ++
Sbjct: 489 TVYPLLALVAIFFGMAL----YLRSLFLTLMVLLGVLGSLLVAFFLYQVAFRMAYFPFVN 544
Query: 680 LPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDE-RLQGETLDQQLGRVLGEVAPSMFLS 738
L L L+ +V ++ I ++ + +L L Q++GR + + +S
Sbjct: 545 LAALL--------LLSSVCANHTLIFFDLWRLSKSQLPSGGLAQRVGRTMHHFGYLLLVS 596
Query: 739 SFSETVAFFLGALSVMPAVHTFSLFAGLAVFIDFLLQI 776
+ + AF+ LS +PAV +LF G AV + L +
Sbjct: 597 GLTTSAAFYASYLSRLPAVRCLALFMGTAVLVHLALTL 634
>gi|5031805 insulin receptor substrate 1 [Homo sapiens]
Length = 1242
Score = 33.9 bits (76), Expect = 1.0
Identities = 13/24 (54%), Positives = 15/24 (62%)
Query: 241 QDCSIVCGPKPQPPPPPAPWTILG 264
+ C C P+PQPPPPP P LG
Sbjct: 1189 KQCPQECTPEPQPPPPPPPHQPLG 1212
>gi|188219559 protein phosphatase 1, regulatory subunit 15B [Homo
sapiens]
Length = 713
Score = 33.9 bits (76), Expect = 1.0
Identities = 22/76 (28%), Positives = 38/76 (50%), Gaps = 4/76 (5%)
Query: 915 NNDSLVQQIFNAAQLDNYTR--IGFAPSSWIDDY--FDWVKPQSSCCRVDNITDQFCNAS 970
+N S+V + N + LD + R + + S + F + P+SSC R D+ Q +A
Sbjct: 214 DNFSVVSYLLNPSYLDCFPRLEVSYQNSDGNSEVVGFQTLTPESSCLREDHCHPQPLSAE 273
Query: 971 VVDPACVRCRPLTPEG 986
++ + C PL+ EG
Sbjct: 274 LIPASWQGCPPLSTEG 289
>gi|20357588 TBP-associated factor 1 isoform 2 [Homo sapiens]
Length = 1872
Score = 33.1 bits (74), Expect = 1.7
Identities = 23/84 (27%), Positives = 30/84 (35%), Gaps = 5/84 (5%)
Query: 176 LCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVT 235
L G D N W+ + ++ I V D + M + C DE
Sbjct: 87 LTGTDGALVNDEGWVR---STEDAVDYSDINEVAEDESRRYQQTMGSLQPLCHSDYDEDD 143
Query: 236 APCSCQDCSIVCGPKPQPPPPPAP 259
C+D I C P PPPPP P
Sbjct: 144 YDADCED--IDCKLMPPPPPPPGP 165
>gi|20357585 TBP-associated factor 1 isoform 1 [Homo sapiens]
Length = 1893
Score = 33.1 bits (74), Expect = 1.7
Identities = 23/84 (27%), Positives = 30/84 (35%), Gaps = 5/84 (5%)
Query: 176 LCGKDADACNATNWIEYMFNKDNGQAPFTITPVFSDFPVHGMEPMNNATKGCDESVDEVT 235
L G D N W+ + ++ I V D + M + C DE
Sbjct: 87 LTGTDGALVNDEGWVR---STEDAVDYSDINEVAEDESRRYQQTMGSLQPLCHSDYDEDD 143
Query: 236 APCSCQDCSIVCGPKPQPPPPPAP 259
C+D I C P PPPPP P
Sbjct: 144 YDADCED--IDCKLMPPPPPPPGP 165
>gi|89886484 XK, Kell blood group complex subunit-related family,
member 6 isoform b [Homo sapiens]
Length = 641
Score = 32.7 bits (73), Expect = 2.3
Identities = 27/92 (29%), Positives = 43/92 (46%), Gaps = 18/92 (19%)
Query: 216 GMEPMNNATK-GCDESVDEVTAPCSCQDCSIVCGPKPQPPPPPA--PWTILGLDAMYVIM 272
G +P +A G D+ + AP + + +P+PPPP PW LD +++++
Sbjct: 79 GRKPRRSAAADGGDQPLQPPAAPGAGRQPPTPSAARPEPPPPQVERPW----LDCLWIVL 134
Query: 273 WITYMAFLLVFFG-----AFFAVWCYRKRYFV 299
LLVFFG + A+ YRK +V
Sbjct: 135 ------ALLVFFGDVGTDLWLALDYYRKGDYV 160
>gi|32401447 solute carrier family 46, member 3 isoform a [Homo
sapiens]
Length = 461
Score = 32.0 bits (71), Expect = 3.9
Identities = 47/199 (23%), Positives = 79/199 (39%), Gaps = 32/199 (16%)
Query: 624 VVISYAIMFLYISLALGH-IKSCRRLLVDSKVSLGIAGILI---VLSSVACSLGVFSYIG 679
+ +S A+ +YI LG +K C V S G + +L A F
Sbjct: 203 IAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFL--- 259
Query: 680 LPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSS 739
L L++ VI + + +G+ IFIL Y+ D L + G LG + FL+S
Sbjct: 260 --LCLLLFTVITYFFVVIGIAPIFIL---YELDSPLCWNEVFIGYGSALGSAS---FLTS 311
Query: 740 FSETVAF----------FLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKR 789
F F F+G + M + + FA + + FL ++ +++ + R
Sbjct: 312 FLGIWLFSYCMEDIHMAFIGIFTTMTGM-AMTAFASTTLMM-FLARVPFLFTIVPFSVLR 369
Query: 790 QEKNRLDIFCCVRGAEDGT 808
+++ VR E GT
Sbjct: 370 SMLSKV-----VRSTEQGT 383
>gi|209571533 solute carrier family 46, member 3 isoform b [Homo
sapiens]
Length = 463
Score = 32.0 bits (71), Expect = 3.9
Identities = 47/199 (23%), Positives = 79/199 (39%), Gaps = 32/199 (16%)
Query: 624 VVISYAIMFLYISLALGH-IKSCRRLLVDSKVSLGIAGILI---VLSSVACSLGVFSYIG 679
+ +S A+ +YI LG +K C V S G + +L A F
Sbjct: 203 IAVSLAVNLIYILFFLGDPVKECSSQNVTMSCSEGFKNLFYRTYMLFKNASGKRRFL--- 259
Query: 680 LPLTLIVIEVIPFLVLAVGVDNIFILVQAYQRDERLQGETLDQQLGRVLGEVAPSMFLSS 739
L L++ VI + + +G+ IFIL Y+ D L + G LG + FL+S
Sbjct: 260 --LCLLLFTVITYFFVVIGIAPIFIL---YELDSPLCWNEVFIGYGSALGSAS---FLTS 311
Query: 740 FSETVAF----------FLGALSVMPAVHTFSLFAGLAVFIDFLLQITCFVSLLGLDIKR 789
F F F+G + M + + FA + + FL ++ +++ + R
Sbjct: 312 FLGIWLFSYCMEDIHMAFIGIFTTMTGM-AMTAFASTTLMM-FLARVPFLFTIVPFSVLR 369
Query: 790 QEKNRLDIFCCVRGAEDGT 808
+++ VR E GT
Sbjct: 370 SMLSKV-----VRSTEQGT 383
>gi|153791492 eukaryotic translation initiation factor 3, subunit
C-like [Homo sapiens]
Length = 914
Score = 31.6 bits (70), Expect = 5.1
Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 1/67 (1%)
Query: 435 LDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCTILSVL-NYFQNSHS 493
LD+ +H ++ I E + AS D T T+ P + N + L + +N+
Sbjct: 814 LDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNER 873
Query: 494 VLDHKKG 500
V DHK+G
Sbjct: 874 VFDHKQG 880
>gi|83700233 eukaryotic translation initiation factor 3, subunit C
[Homo sapiens]
Length = 913
Score = 31.6 bits (70), Expect = 5.1
Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 1/67 (1%)
Query: 435 LDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCTILSVL-NYFQNSHS 493
LD+ +H ++ I E + AS D T T+ P + N + L + +N+
Sbjct: 813 LDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNER 872
Query: 494 VLDHKKG 500
V DHK+G
Sbjct: 873 VFDHKQG 879
>gi|4503525 eukaryotic translation initiation factor 3, subunit C
[Homo sapiens]
Length = 913
Score = 31.6 bits (70), Expect = 5.1
Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 1/67 (1%)
Query: 435 LDIQILHQVLDLQIAIENITASYDNETVTLQDICLAPLSPYNTNCTILSVL-NYFQNSHS 493
LD+ +H ++ I E + AS D T T+ P + N + L + +N+
Sbjct: 813 LDLPTVHSIISKMIINEELMASLDQPTQTVVMHRTEPTAQQNLALQLAEKLGSLVENNER 872
Query: 494 VLDHKKG 500
V DHK+G
Sbjct: 873 VFDHKQG 879
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.325 0.140 0.438
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,341,359
Number of Sequences: 37866
Number of extensions: 2334109
Number of successful extensions: 12557
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 21
Number of HSP's that attempted gapping in prelim test: 12409
Number of HSP's gapped (non-prelim): 101
length of query: 1278
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1164
effective length of database: 13,930,794
effective search space: 16215444216
effective search space used: 16215444216
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.