Guide to the Human Genome
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Name: HMGCR Sequence: fasta or formatted (835aa) NCBI GI: 196049380
Description:

3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 2

Referenced in:

Cholesterol Biosynthesis
Pancreas and Insulin

Other entries for this name:
alt prot [888aa] 3-hydroxy-3-methylglutaryl-Coenzyme A reductase isoform 1
Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             7.5         63           2
 C cysteine            2.8         23           2
 D aspartate           3.0         25           1
 E glutamate           7.1         59           4
 F phenylalanine       3.7         31           2
 G glycine             6.3         53           3
 H histidine           1.7         14           1
 I isoleucine          6.8         57           3
 K lysine              4.8         40           2
 L leucine            10.7         89           3
 M methionine          3.6         30           2
 N asparagine          4.9         41           2
 P proline             4.0         33           1
 Q glutamine           3.6         30           2
 R arginine            4.9         41           2
 S serine              8.4         70           2
 T threonine           5.9         49           3
 V valine              7.4         62           2
 W tryptophan          0.8          7           1
 Y tyrosine            2.2         18           1
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   3-hydroxy-3-methylglutaryl-Coenzyme A reductase iso... 
HMGCR                 0.985   3-hydroxy-3-methylglutaryl-Coenzyme A reductase isofo...
SCAP                  0.028   SREBF chaperone protein 
NPC1                  0.015   Niemann-Pick disease, type C1 precursor 
C6orf138              0.014   hypothetical protein LOC442213 
PTCHD3                0.011   patched domain containing 3 
PTCHD1                0.010   patched domain containing 1 
CELSR1                0.005   cadherin EGF LAG seven-pass G-type receptor 1 
RASAL3                0.004   RAS protein activator like 3 
CAPZA3                0.004   capping protein alpha 3 
C20orf117             0.003   hypothetical protein LOC140710 
OTUD6B                0.003   OTU domain containing 6B 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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