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Search of human proteins with 4557719
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557719 DNA ligase I [Homo sapiens]
(919 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557719 DNA ligase I [Homo sapiens] 1820 0.0
gi|73747844 ligase III, DNA, ATP-dependent isoform beta precurso... 175 2e-43
gi|73747829 ligase III, DNA, ATP-dependent isoform alpha precurs... 175 2e-43
gi|46255052 DNA ligase IV [Homo sapiens] 124 5e-28
gi|23199993 DNA ligase IV [Homo sapiens] 124 5e-28
gi|148539894 DNA ligase IV [Homo sapiens] 124 5e-28
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 75 2e-13
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 66 2e-10
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 66 2e-10
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 65 4e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 61 4e-09
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 61 4e-09
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 61 4e-09
gi|157266334 tubby like protein 1 [Homo sapiens] 58 5e-08
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 57 6e-08
gi|58082089 hypothetical protein LOC161394 [Homo sapiens] 57 8e-08
gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens] 55 4e-07
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 54 5e-07
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 54 5e-07
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 54 5e-07
gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c ... 54 5e-07
gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo sap... 52 3e-06
gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo sap... 52 3e-06
gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo sapi... 52 3e-06
gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens] 52 3e-06
gi|110349719 titin isoform N2-A [Homo sapiens] 52 3e-06
gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo sa... 52 3e-06
gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo sa... 52 3e-06
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 52 3e-06
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 52 3e-06
>gi|4557719 DNA ligase I [Homo sapiens]
Length = 919
Score = 1820 bits (4715), Expect = 0.0
Identities = 919/919 (100%), Positives = 919/919 (100%)
Query: 1 MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA 60
MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA
Sbjct: 1 MQRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKA 60
Query: 61 ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK 120
ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK
Sbjct: 61 ARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK 120
Query: 121 RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ 180
RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ
Sbjct: 121 RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ 180
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK 240
PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK
Sbjct: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK 240
Query: 241 KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE 300
KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE
Sbjct: 241 KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVARTFEKIE 300
Query: 301 EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ 360
EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ
Sbjct: 301 EVSARLRMVETLSNLLRSVVALSPPDLLPVLYLSLNHLGPPQQGLELGVGDGVLLKAVAQ 360
Query: 361 ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST 420
ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST
Sbjct: 361 ATGRQLESVRAEAAEKGDVGLVAENSRSTQRLMLPPPPLTASGVFSKFRDIARLTGSAST 420
Query: 421 AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM 480
AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM
Sbjct: 421 AKKIDIIKGLFVACRHSEARFIARSLSGRLRLGLAEQSVLAALSQAVSLTPPGQEFPPAM 480
Query: 481 VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL 540
VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL
Sbjct: 481 VDAGKGKTAEARKTWLEEQGMILKQTFCEVPDLDRIIPVLLEHGLERLPEHCKLSPGIPL 540
Query: 541 KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD 600
KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD
Sbjct: 541 KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQEDNTGKYPD 600
Query: 601 IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF 660
IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF
Sbjct: 601 IISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAF 660
Query: 661 DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE 720
DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE
Sbjct: 661 DLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQSVKDSCE 720
Query: 721 GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL 780
GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL
Sbjct: 721 GLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRAGRYGGFLL 780
Query: 781 ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA 840
ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA
Sbjct: 781 ASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPRPYVRIDGAVIPDHWLDPSA 840
Query: 841 VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ 900
VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ
Sbjct: 841 VWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPEQATTSAQVACLYRKQ 900
Query: 901 SQIQNQQGEDSGSDPEDTY 919
SQIQNQQGEDSGSDPEDTY
Sbjct: 901 SQIQNQQGEDSGSDPEDTY 919
>gi|73747844 ligase III, DNA, ATP-dependent isoform beta precursor
[Homo sapiens]
Length = 949
Score = 175 bits (443), Expect = 2e-43
Identities = 124/373 (33%), Positives = 188/373 (50%), Gaps = 35/373 (9%)
Query: 539 PLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQED----N 594
P++PMLA + + +K+ F+ E KYDG+R Q+H G FSR+ +
Sbjct: 480 PVQPMLAEACKSVEYAMKKCPNGMFS-EIKYDGERVQVHK-NGDHFSYFSRSLKPVLPHK 537
Query: 595 TGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQ 654
+ D I + P S ILD+E + D + + PF L K+ A+
Sbjct: 538 VAHFKDYIPQA----FPGGHSMILDSEVLLIDNKTGKPLPFGTLGVHKK----AAFQDAN 589
Query: 655 VCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQS 714
VCL+ FD IY N SL+ PL RR+ L +N VE +F+ +A+ + +
Sbjct: 590 VCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNRIMFSEMKRVTKALDLADMITRV 649
Query: 715 VKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLD--GVGDTLDLVVIGAYLGRGKRA 772
+++ EGL++K DV TYE KR +WLK+KKDYL+ + DT DLVV+GA+ G+G +
Sbjct: 650 IQEGLEGLVLK--DVKGTYEPGKR--HWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG 705
Query: 773 GRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVL---PSPRP-YVRIDG 828
G FL+ YD S++ + K G D L L + + PS P +++++
Sbjct: 706 GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNK 765
Query: 829 AVIPDHWL-DP--SAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPE 885
PD + DP +AVWE+ A+ S S + A GIS+RFPR R+R+DK +
Sbjct: 766 IYYPDFIVPDPKKAAVWEITGAEFSKSEAHTA--------DGISIRFPRCTRIRDDKDWK 817
Query: 886 QATTSAQVACLYR 898
AT Q+ LY+
Sbjct: 818 SATNLPQLKELYQ 830
>gi|73747829 ligase III, DNA, ATP-dependent isoform alpha precursor
[Homo sapiens]
Length = 1009
Score = 175 bits (443), Expect = 2e-43
Identities = 124/373 (33%), Positives = 188/373 (50%), Gaps = 35/373 (9%)
Query: 539 PLKPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRNQED----N 594
P++PMLA + + +K+ F+ E KYDG+R Q+H G FSR+ +
Sbjct: 480 PVQPMLAEACKSVEYAMKKCPNGMFS-EIKYDGERVQVHK-NGDHFSYFSRSLKPVLPHK 537
Query: 595 TGKYPDIISRIPKIKLPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQ 654
+ D I + P S ILD+E + D + + PF L K+ A+
Sbjct: 538 VAHFKDYIPQA----FPGGHSMILDSEVLLIDNKTGKPLPFGTLGVHKK----AAFQDAN 589
Query: 655 VCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEGEFVFATSLDTKDIEQIAEFLEQS 714
VCL+ FD IY N SL+ PL RR+ L +N VE +F+ +A+ + +
Sbjct: 590 VCLFVFDCIYFNDVSLMDRPLCERRKFLHDNMVEIPNRIMFSEMKRVTKALDLADMITRV 649
Query: 715 VKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLD--GVGDTLDLVVIGAYLGRGKRA 772
+++ EGL++K DV TYE KR +WLK+KKDYL+ + DT DLVV+GA+ G+G +
Sbjct: 650 IQEGLEGLVLK--DVKGTYEPGKR--HWLKVKKDYLNEGAMADTADLVVLGAFYGQGSKG 705
Query: 773 GRYGGFLLASYDEDSEELQAICKLGTGFSDEELEEHHQSLKALVL---PSPRP-YVRIDG 828
G FL+ YD S++ + K G D L L + + PS P +++++
Sbjct: 706 GMMSIFLMGCYDPGSQKWCTVTKCAGGHDDATLARLQNELDMVKISKDPSKIPSWLKVNK 765
Query: 829 AVIPDHWL-DP--SAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDKQPE 885
PD + DP +AVWE+ A+ S S + A GIS+RFPR R+R+DK +
Sbjct: 766 IYYPDFIVPDPKKAAVWEITGAEFSKSEAHTA--------DGISIRFPRCTRIRDDKDWK 817
Query: 886 QATTSAQVACLYR 898
AT Q+ LY+
Sbjct: 818 SATNLPQLKELYQ 830
>gi|46255052 DNA ligase IV [Homo sapiens]
Length = 911
Score = 124 bits (310), Expect = 5e-28
Identities = 109/379 (28%), Positives = 175/379 (46%), Gaps = 36/379 (9%)
Query: 541 KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRN---QEDNTGK 597
KPMLA I + K + +F E K DG+R Q+H +G K FSRN D G
Sbjct: 247 KPMLA-AIADIEHIEKDMKHQSFYIETKLDGERMQMHK-DGDVYKYFSRNGYNYTDQFGA 304
Query: 598 YPDIISRIPKIK---LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQ 654
P S P I + ILD E +A++ Q F T+ + + +Q
Sbjct: 305 SPTEGSLTPFIHNAFKADIQICILDGEMMAYN---PNTQTFMQKGTKFDIKRMVEDSDLQ 361
Query: 655 VCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEG--EFVFATSLDTKDIEQIAEFLE 712
C FD++ +N + L E L +R ++L F G E V T TK+ ++ + L
Sbjct: 362 TCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKN--EVIDALN 419
Query: 713 QSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRA 772
+++ EG+MVK + Y+ KR WLK+K +Y+ G+ D LD++++G Y G+G R
Sbjct: 420 EAIDKREEGIMVK--QPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRG 477
Query: 773 GRYGGFLLASYD-----EDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPR---PYV 824
G FL A + E + ++G+G + +EL + L P R P
Sbjct: 478 GMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSS 537
Query: 825 RIDGAVIPDHWLDP--SAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDK 882
+ G P+ +++P S + ++K A++ S +Y G +LRFPR ++R+DK
Sbjct: 538 ILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKT---------GCTLRFPRIEKIRDDK 588
Query: 883 QPEQATTSAQVACLYRKQS 901
+ + T + L K S
Sbjct: 589 EWHECMTLDDLEQLRGKAS 607
>gi|23199993 DNA ligase IV [Homo sapiens]
Length = 911
Score = 124 bits (310), Expect = 5e-28
Identities = 109/379 (28%), Positives = 175/379 (46%), Gaps = 36/379 (9%)
Query: 541 KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRN---QEDNTGK 597
KPMLA I + K + +F E K DG+R Q+H +G K FSRN D G
Sbjct: 247 KPMLA-AIADIEHIEKDMKHQSFYIETKLDGERMQMHK-DGDVYKYFSRNGYNYTDQFGA 304
Query: 598 YPDIISRIPKIK---LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQ 654
P S P I + ILD E +A++ Q F T+ + + +Q
Sbjct: 305 SPTEGSLTPFIHNAFKADIQICILDGEMMAYN---PNTQTFMQKGTKFDIKRMVEDSDLQ 361
Query: 655 VCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEG--EFVFATSLDTKDIEQIAEFLE 712
C FD++ +N + L E L +R ++L F G E V T TK+ ++ + L
Sbjct: 362 TCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKN--EVIDALN 419
Query: 713 QSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRA 772
+++ EG+MVK + Y+ KR WLK+K +Y+ G+ D LD++++G Y G+G R
Sbjct: 420 EAIDKREEGIMVK--QPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRG 477
Query: 773 GRYGGFLLASYD-----EDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPR---PYV 824
G FL A + E + ++G+G + +EL + L P R P
Sbjct: 478 GMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSS 537
Query: 825 RIDGAVIPDHWLDP--SAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDK 882
+ G P+ +++P S + ++K A++ S +Y G +LRFPR ++R+DK
Sbjct: 538 ILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKT---------GCTLRFPRIEKIRDDK 588
Query: 883 QPEQATTSAQVACLYRKQS 901
+ + T + L K S
Sbjct: 589 EWHECMTLDDLEQLRGKAS 607
>gi|148539894 DNA ligase IV [Homo sapiens]
Length = 911
Score = 124 bits (310), Expect = 5e-28
Identities = 109/379 (28%), Positives = 175/379 (46%), Gaps = 36/379 (9%)
Query: 541 KPMLAHPTRGISEVLKRFEEAAFTCEYKYDGQRAQIHALEGGEVKIFSRN---QEDNTGK 597
KPMLA I + K + +F E K DG+R Q+H +G K FSRN D G
Sbjct: 247 KPMLA-AIADIEHIEKDMKHQSFYIETKLDGERMQMHK-DGDVYKYFSRNGYNYTDQFGA 304
Query: 598 YPDIISRIPKIK---LPSVTSFILDTEAVAWDREKKQIQPFQVLTTRKRKEVDASEIQVQ 654
P S P I + ILD E +A++ Q F T+ + + +Q
Sbjct: 305 SPTEGSLTPFIHNAFKADIQICILDGEMMAYN---PNTQTFMQKGTKFDIKRMVEDSDLQ 361
Query: 655 VCLYAFDLIYLNGESLVREPLSRRRQLLRENFVETEG--EFVFATSLDTKDIEQIAEFLE 712
C FD++ +N + L E L +R ++L F G E V T TK+ ++ + L
Sbjct: 362 TCYCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKN--EVIDALN 419
Query: 713 QSVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLKKDYLDGVGDTLDLVVIGAYLGRGKRA 772
+++ EG+MVK + Y+ KR WLK+K +Y+ G+ D LD++++G Y G+G R
Sbjct: 420 EAIDKREEGIMVK--QPLSIYKPDKRGEGWLKIKPEYVSGLMDELDILIVGGYWGKGSRG 477
Query: 773 GRYGGFLLASYD-----EDSEELQAICKLGTGFSDEELEEHHQSLKALVLPSPR---PYV 824
G FL A + E + ++G+G + +EL + L P R P
Sbjct: 478 GMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYWKPFHRKAPPSS 537
Query: 825 RIDGAVIPDHWLDP--SAVWEVKCADLSLSPIYPAARGLVDSDKGISLRFPRFIRVREDK 882
+ G P+ +++P S + ++K A++ S +Y G +LRFPR ++R+DK
Sbjct: 538 ILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKT---------GCTLRFPRIEKIRDDK 588
Query: 883 QPEQATTSAQVACLYRKQS 901
+ + T + L K S
Sbjct: 589 EWHECMTLDDLEQLRGKAS 607
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 75.5 bits (184), Expect = 2e-13
Identities = 82/320 (25%), Positives = 130/320 (40%), Gaps = 45/320 (14%)
Query: 14 EGKAKKPEKEASNSSRETEPPPKAA--LKEWNGVVSESDSPVKRPGRKAARVLGSEGEEE 71
+ +AK PEK S E + P KA +KE ++ SPVK + + ++ +
Sbjct: 671 KAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEK---AKSPVK 727
Query: 72 DEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKR 131
+EA +P K + P + + P A SPE +L SP +P+ R A K P++
Sbjct: 728 EEAKTPEKAKSPVKE--EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK-FPEK 784
Query: 132 TIQEVLEEQSEDEDREAKRKKEEE--EEETPKESLTEAEVATE------------KEGED 177
V EE E ++ K++ + E+E PK+ ++ V E K+ E+
Sbjct: 785 AKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEE 844
Query: 178 GDQPTTP------------------PKPLKTSKAETPTESVSEPEVATKQELQEEEEQTK 219
P TP PKP K E E E +V K+E E++++
Sbjct: 845 EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP 904
Query: 220 PPRRAPKTLSSFFTPRKPAVKKEVKEEEP-GAPGKEGAAEGPLDPSGYNPAKNNYHPVED 278
P + KP K EV ++EP A KE + P + P K + E+
Sbjct: 905 TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSK--PAEKKEAAPEKKD--TKEE 960
Query: 279 ACWKPGQKVPYLAVARTFEK 298
KP +K A A+ +K
Sbjct: 961 KAKKPEEKPKTEAKAKEDDK 980
Score = 68.9 bits (167), Expect = 2e-11
Identities = 74/270 (27%), Positives = 116/270 (42%), Gaps = 40/270 (14%)
Query: 13 KEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSP--VKRPGRKAARVLGSEGEE 70
K +AK P KE + S P K K + V E SP K P ++ A+ E +
Sbjct: 762 KSPEAKTPAKEEARS-----PADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Query: 71 EDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQL-- 128
++E SP K ++ + PP+ A + A+ DS PK+ + ++
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Query: 129 --------PKRTIQEVLEEQSEDE------DREAKRKKEEEEEETPKESLTEAEVATEKE 174
PK + E +E++ED+ ++EA K E +E+ PKE + EVA +KE
Sbjct: 877 KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKE---KTEVA-KKE 932
Query: 175 GED--GDQPTTP--PKPLKTSKAETPTESVSEPEVATKQELQEEE-------EQTKPPRR 223
+D +P+ P K K +T E +PE K E + +E E +KP +
Sbjct: 933 PDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKP--K 990
Query: 224 APKTLSSFFTPRKPAVKKEVKEEEPGAPGK 253
A K S T +K + E E+ A GK
Sbjct: 991 AEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 67.8 bits (164), Expect = 4e-11
Identities = 83/327 (25%), Positives = 129/327 (39%), Gaps = 50/327 (15%)
Query: 12 KKEGKAKK--PEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGE 69
++EGK ++ E+EA ET+ PP +E E+ SPVK + A E E
Sbjct: 480 EEEGKEEEGGEEEEAEGGEEETKSPPA---EEAASPEKEAKSPVKEEAKSPAEAKSPEKE 536
Query: 70 EED---EALSPAKGQKPALDCSQVSPPRPATSPENNASLSDT---SPMDS-SPSGIPKRR 122
E E SP K + PA + ++ SPP A SPE + S SP + SP+ +
Sbjct: 537 EAKSPAEVKSPEKAKSPAKEEAK-SPPE-AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 594
Query: 123 TARKQLPKRTIQEVLEEQS----------EDEDREAKRKKEEEEEETPKESLTEAEVATE 172
A + P++ V EE E+ A+ K E+ + KE E A
Sbjct: 595 PAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKS 654
Query: 173 KEGEDGDQPTTPPKPLKTS-----KAETPTESVSEPEVATKQELQEE-----------EE 216
E E+ P P+K KA++P ++ ++ K ++EE +E
Sbjct: 655 PEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKE 714
Query: 217 QTKPPRRAPKTLSSFF-TPRKPA--VKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNY 273
+ K P +A + TP K VK+E K E ++ P PAK
Sbjct: 715 EAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAK--- 771
Query: 274 HPVEDACWKPGQKVPYLAVARTFEKIE 300
+ P K P A + E+++
Sbjct: 772 ----EEARSPADKFPEKAKSPVKEEVK 794
Score = 57.8 bits (138), Expect = 5e-08
Identities = 70/291 (24%), Positives = 118/291 (40%), Gaps = 52/291 (17%)
Query: 11 PKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEE 70
P KE +AK PEK S E + P KA + V E+ SP K + A+ L + E
Sbjct: 711 PVKE-EAKSPEKAKSPVKEEAKTPEKAK----SPVKEEAKSPEKAKSPEKAKTLDVKSPE 765
Query: 71 -----EDEALSPA-----KGQKPALDCSQVSPPRPATSP---ENNASLSDTSPMDSSPSG 117
++EA SPA K + P + +V P A SP + A + + S
Sbjct: 766 AKTPAKEEARSPADKFPEKAKSPVKE--EVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSP 823
Query: 118 IPKRRTAR----KQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEA------ 167
+ + + K+ PK+ +E + E+++ +K+E ++E PK + E
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 168 ---EVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEP----EVATKQ---------EL 211
E E + E+ + P P K + A+ + ++P EVA K+
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSK 943
Query: 212 QEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEE------EPGAPGKEGA 256
E+++ P ++ K + KP + + KE+ EP P E A
Sbjct: 944 PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA 994
Score = 52.4 bits (124), Expect = 2e-06
Identities = 50/200 (25%), Positives = 83/200 (41%), Gaps = 30/200 (15%)
Query: 113 SSPSGIPKRRTAR-----------KQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPK 161
S P G+PK + K + K + V+ E+ +E + + EEEE+E +
Sbjct: 421 SLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKE 480
Query: 162 ESLTEAEVATEKEGEDGDQPTTPP------KPLKTSK------AETPTESVS--EPEVAT 207
E E E E+E E G++ T P P K +K A++P E+ S + E +
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
Query: 208 KQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKK--EVKEEEPGAPGKEGAAEGPLDPSG 265
E++ E+ P + K+ +P K K EVK E + A+ P +
Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600
Query: 266 YNPAKNNYHPVEDACWKPGQ 285
AK+ PV++ P +
Sbjct: 601 PEKAKS---PVKEEAKSPAE 617
Score = 49.7 bits (117), Expect = 1e-05
Identities = 67/302 (22%), Positives = 119/302 (39%), Gaps = 32/302 (10%)
Query: 4 SIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARV 63
S+ + K E K K EK + E + + E V E + K K
Sbjct: 431 SVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTE--EVTEEEEKEAKEEEGKE--- 485
Query: 64 LGSEGEEEDEALSPAKGQKPALDCSQVSPP-RPATSPENNASLSDTSPMDSSPSGIPKRR 122
EG EE+EA + K SPP A SPE A SP+ + +
Sbjct: 486 --EEGGEEEEAEGGEEETK--------SPPAEEAASPEKEAK----SPVKEEAKSPAEAK 531
Query: 123 TARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGED--GDQ 180
+ K+ K + E+++ +E + E + +E+ + AEV + ++ + ++
Sbjct: 532 SPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEE 591
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEE---QTKPPRRAPKTLSSFFTPRKP 237
+P + KA++P + ++ K ++EE + + K P +A + P
Sbjct: 592 AKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKE--EAKSP 649
Query: 238 AVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQ-KVPYLAVARTF 296
K ++EE +P K A+ P+ +P K PV+ P + K P A++
Sbjct: 650 EKAKSPEKEEAKSPEK---AKSPVKAEAKSPEKAK-SPVKAEAKSPEKAKSPVKEEAKSP 705
Query: 297 EK 298
EK
Sbjct: 706 EK 707
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 65.9 bits (159), Expect = 2e-10
Identities = 57/194 (29%), Positives = 88/194 (45%), Gaps = 20/194 (10%)
Query: 112 DSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEE----ETPKESLTEA 167
+ P + A+K K T EV EE+ E E+ E + ++EEE+E + +E +E
Sbjct: 496 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 555
Query: 168 EVATEK---EGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPR-R 223
E ++EK E E+G+ +K E E SE EVATK+EL + + KP + +
Sbjct: 556 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE-EVATKEELVADAKVEKPEKAK 614
Query: 224 APKTLSSFFTPRKPAVKKEVKEEEPGAP---------GKEGAAEGPLDPSGYNPAKNNYH 274
+P S K V K EE+ +P GK + P++ G +P +
Sbjct: 615 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS-- 672
Query: 275 PVEDACWKPGQKVP 288
PVE+ P K P
Sbjct: 673 PVEEKAKSPVPKSP 686
Score = 59.7 bits (143), Expect = 1e-08
Identities = 58/222 (26%), Positives = 105/222 (47%), Gaps = 20/222 (9%)
Query: 12 KKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSE-----SDSPVKRPGRKAARVLGS 66
K+EG+ ++ E EA E E + ++E + V+ +D+ V++P + + V S
Sbjct: 561 KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 620
Query: 67 EGEEEDEALSPA-----KGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKR 121
EE+ ++ P KG+ P + S V + P++ SP+ SP
Sbjct: 621 PVEEKGKSPVPKSPVEEKGKSP-VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV----E 675
Query: 122 RTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQP 181
A+ +PK ++E + ++E E K ++E+E +E PKE E + K+ + +
Sbjct: 676 EKAKSPVPKSPVEEA-KSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 734
Query: 182 TTPPKPLKTSKAETPTESVS-EPEVATKQE---LQEEEEQTK 219
+P K ++ T T+SV E TK+E LQ+E+E+ K
Sbjct: 735 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 776
Score = 39.3 bits (90), Expect = 0.017
Identities = 37/149 (24%), Positives = 60/149 (40%), Gaps = 10/149 (6%)
Query: 120 KRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETP---------KESLTEAEVA 170
K + + + PK +Q E+ +E + K E EE T KE EA
Sbjct: 435 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 494
Query: 171 TEKEGEDGDQPTTPPK-PLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLS 229
E+E E ++ K P+K + E E + E ++E +EE+E K +
Sbjct: 495 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 554
Query: 230 SFFTPRKPAVKKEVKEEEPGAPGKEGAAE 258
+ K ++E E E A G+E A+
Sbjct: 555 KEGSSEKEEGEQEEGETEAEAEGEEAEAK 583
Score = 39.3 bits (90), Expect = 0.017
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 10/145 (6%)
Query: 119 PKRRTARKQLPKRTIQEVLEEQSEDEDR----EAKRKKEEEEEETPKESLTEAEVATEKE 174
PK + ++ + ++E++EE ++++ EA EE + KE EA E+E
Sbjct: 439 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE 498
Query: 175 GEDGDQPTTPPK-PLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFT 233
E ++ K P+K + E E E E QE +EEE++ +A + S
Sbjct: 499 PEAEEEEVAAKKSPVKATAPEVKEEE-GEKEEEEGQEEEEEEDEGAKSDQAEEGGSE--- 554
Query: 234 PRKPAVKKEVKEEEPGAPGKEGAAE 258
++ + +KE E+E G E E
Sbjct: 555 -KEGSSEKEEGEQEEGETEAEAEGE 578
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 65.9 bits (159), Expect = 2e-10
Identities = 57/194 (29%), Positives = 88/194 (45%), Gaps = 20/194 (10%)
Query: 112 DSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEE----ETPKESLTEA 167
+ P + A+K K T EV EE+ E E+ E + ++EEE+E + +E +E
Sbjct: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
Query: 168 EVATEK---EGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPR-R 223
E ++EK E E+G+ +K E E SE EVATK+EL + + KP + +
Sbjct: 180 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE-EVATKEELVADAKVEKPEKAK 238
Query: 224 APKTLSSFFTPRKPAVKKEVKEEEPGAP---------GKEGAAEGPLDPSGYNPAKNNYH 274
+P S K V K EE+ +P GK + P++ G +P +
Sbjct: 239 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS-- 296
Query: 275 PVEDACWKPGQKVP 288
PVE+ P K P
Sbjct: 297 PVEEKAKSPVPKSP 310
Score = 59.7 bits (143), Expect = 1e-08
Identities = 58/222 (26%), Positives = 105/222 (47%), Gaps = 20/222 (9%)
Query: 12 KKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSE-----SDSPVKRPGRKAARVLGS 66
K+EG+ ++ E EA E E + ++E + V+ +D+ V++P + + V S
Sbjct: 185 KEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKS 244
Query: 67 EGEEEDEALSPA-----KGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKR 121
EE+ ++ P KG+ P + S V + P++ SP+ SP
Sbjct: 245 PVEEKGKSPVPKSPVEEKGKSP-VPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV----E 299
Query: 122 RTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQP 181
A+ +PK ++E + ++E E K ++E+E +E PKE E + K+ + +
Sbjct: 300 EKAKSPVPKSPVEEA-KSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
Query: 182 TTPPKPLKTSKAETPTESVS-EPEVATKQE---LQEEEEQTK 219
+P K ++ T T+SV E TK+E LQ+E+E+ K
Sbjct: 359 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 400
Score = 39.3 bits (90), Expect = 0.017
Identities = 37/149 (24%), Positives = 60/149 (40%), Gaps = 10/149 (6%)
Query: 120 KRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETP---------KESLTEAEVA 170
K + + + PK +Q E+ +E + K E EE T KE EA
Sbjct: 59 KIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEE 118
Query: 171 TEKEGEDGDQPTTPPK-PLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLS 229
E+E E ++ K P+K + E E + E ++E +EE+E K +
Sbjct: 119 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 178
Query: 230 SFFTPRKPAVKKEVKEEEPGAPGKEGAAE 258
+ K ++E E E A G+E A+
Sbjct: 179 KEGSSEKEEGEQEEGETEAEAEGEEAEAK 207
Score = 39.3 bits (90), Expect = 0.017
Identities = 37/145 (25%), Positives = 65/145 (44%), Gaps = 10/145 (6%)
Query: 119 PKRRTARKQLPKRTIQEVLEEQSEDEDR----EAKRKKEEEEEETPKESLTEAEVATEKE 174
PK + ++ + ++E++EE ++++ EA EE + KE EA E+E
Sbjct: 63 PKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEE 122
Query: 175 GEDGDQPTTPPK-PLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFT 233
E ++ K P+K + E E E E QE +EEE++ +A + S
Sbjct: 123 PEAEEEEVAAKKSPVKATAPEVKEEE-GEKEEEEGQEEEEEEDEGAKSDQAEEGGSE--- 178
Query: 234 PRKPAVKKEVKEEEPGAPGKEGAAE 258
++ + +KE E+E G E E
Sbjct: 179 -KEGSSEKEEGEQEEGETEAEAEGE 202
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 64.7 bits (156), Expect = 4e-10
Identities = 62/249 (24%), Positives = 102/249 (40%), Gaps = 31/249 (12%)
Query: 17 AKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKR----PGRKAARVLGS------ 66
AKK +K+AS+S E + ++ ++ P KR PG+ AA+ S
Sbjct: 75 AKKAKKKASSSDSEDSSEEEEEVQ--GPPAKKAAVPAKRVGLPPGKAAAKASESSSSEES 132
Query: 67 --EGEEEDEALSPA-KGQKPALDCSQVSPPRPATSP-ENNASLSDTSPMDSSPSGIP--- 119
+ +EED+ P KG KP ++ P + +S ++++S D P + P P
Sbjct: 133 SDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTV 192
Query: 120 KRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGD 179
K +T P R ++ ++ + ++ E K + T + +K+
Sbjct: 193 KAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQ----- 247
Query: 180 QPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAV 239
P+K A TPT S E ++ E EEEQ KP + P SS P P
Sbjct: 248 --VVAKAPVKA--ATTPTRKSSSSEDSSSDE---EEEQKKPMKNKPGPYSSVPPPSAPPP 300
Query: 240 KKEVKEEEP 248
KK + + P
Sbjct: 301 KKSLGTQPP 309
Score = 59.7 bits (143), Expect = 1e-08
Identities = 67/281 (23%), Positives = 108/281 (38%), Gaps = 65/281 (23%)
Query: 17 AKKPEKEA------SNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVL------ 64
AK P K+A S+SS E EPP K V +P R A ++
Sbjct: 157 AKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAAS 216
Query: 65 ---------GSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSS- 114
S+ EE++A + K P +P + AT+P +S S+ S D
Sbjct: 217 SSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEE 276
Query: 115 ------------------PSGIPKRRTARKQLPKRTIQEVLE-EQSEDEDREAKRKKEEE 155
PS P +++ Q PK+ +++ E SED E+ EEE
Sbjct: 277 EQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEE 336
Query: 156 EEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEE 215
++ K +++A TT P P K + AE+ ++S + + E++
Sbjct: 337 KKPPTKAVVSKA--------------TTKPPPAKKA-AESSSDS-------SDSDSSEDD 374
Query: 216 EQTKPPRRAPKTLSS--FFTPRKPAVKKEVKEEEPGAPGKE 254
E P K S+ T + PAVK ++P G++
Sbjct: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQK 415
Score = 55.1 bits (131), Expect = 3e-07
Identities = 62/279 (22%), Positives = 107/279 (38%), Gaps = 28/279 (10%)
Query: 15 GKAKKPEKEASNSSRETEPPPKAALKEW---NGVVSESDSPVKRPGRKAARVLGSEGEEE 71
GKA E+S+S ++ + K+ GV ++ + P + + S+ E
Sbjct: 117 GKAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSE 176
Query: 72 DEALSPAKGQKPALDCSQV-----SPPRPATSPE---NNASLSDTSPMDSSPSGIPKRRT 123
DE P K QKP + V +PP+PA + N + S +S SS S
Sbjct: 177 DE---PPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEE 233
Query: 124 ARKQLPKRTI--QEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGD-Q 180
PK+T+ ++V+ + RK E+ + E + + K G
Sbjct: 234 KAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVP 293
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK 240
P + P P K+ + P ++V + + E +E SS +KP K
Sbjct: 294 PPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESD-----------SSSEEEKKPPTK 342
Query: 241 KEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDA 279
V + P + AAE D S + ++++ P + A
Sbjct: 343 AVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPA 381
Score = 53.9 bits (128), Expect = 7e-07
Identities = 61/258 (23%), Positives = 102/258 (39%), Gaps = 49/258 (18%)
Query: 11 PKKEGKAKKPEKEASNSSRETE--------PPPKAALKEWNGVVSESDSPVKRPGRKAAR 62
PKK + ++P + + +SS E++ PP KA + + + P K+ ++
Sbjct: 309 PKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSK----ATTKPPPAKKAAESSSD 364
Query: 63 VLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRR 122
S+ E+DEA P +PA + +N S P ++ S K
Sbjct: 365 SSDSDSSEDDEA-----------------PSKPAGTTKN----SSNKPAVTTKSPAVKPA 403
Query: 123 TARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPT 182
A KQ P Q++L R+A EEE + +E T+ VAT K
Sbjct: 404 AAPKQ-PVGGGQKLLT-------RKADSSSSEEESSSSEEEKTKKMVATTKP------KA 449
Query: 183 TPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPP--RRAPKTLSSFFTPRKPAVK 240
T L + P S + +EEEE+T ++ P+ ++ P KPA
Sbjct: 450 TAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASA 509
Query: 241 KEVKEEEPGAPGKEGAAE 258
K+ K E + + ++E
Sbjct: 510 KKGKAESSNSSSSDDSSE 527
Score = 49.3 bits (116), Expect = 2e-05
Identities = 61/255 (23%), Positives = 97/255 (38%), Gaps = 32/255 (12%)
Query: 13 KEGKAKKPEKEASNSSRE------TEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGS 66
++ + E+E+S+S E PKA K + ++ R + S
Sbjct: 419 RKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSS 478
Query: 67 EGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSS----PSGIPKRR 122
E EEE + S K +KP +P +PA++ + A S++S D S + +
Sbjct: 479 EEEEEKTSKSAVK-KKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKG 537
Query: 123 TARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPT 182
+ R Q PK L Q + +A + EEEEEE K A V K G
Sbjct: 538 SPRPQAPKANGTSALTAQ----NGKAAKNSEEEEEEKKK-----AAVVVSKSGS------ 582
Query: 183 TPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKE 242
LK K + P+ A K +LQ K + + S F R+ ++ +
Sbjct: 583 -----LKKRKQNEAAKEAETPQ-AKKIKLQTPNTFPKRKKGEKRASSPFRRVREEEIEVD 636
Query: 243 VKEEEPGAPGKEGAA 257
+ + K GAA
Sbjct: 637 SRVADNSFDAKRGAA 651
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 61.2 bits (147), Expect = 4e-09
Identities = 70/272 (25%), Positives = 104/272 (38%), Gaps = 42/272 (15%)
Query: 13 KEGKAKKPEKEASNSSRETEP----PPKA------ALKEWNGVVSESDSPVKRPGRKAAR 62
K K KP+ E + S + + P KA + K+W+G + D+ K R
Sbjct: 122 KSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRIN 181
Query: 63 VLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRR 122
G G+E DE L KGQK +Q + P P N + + K+
Sbjct: 182 SSGESGDESDEFLQSRKGQKK----NQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKE 237
Query: 123 TARK-------QLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT---------- 165
RK +L K +E LE +D+ ++ K + + EEET K +T
Sbjct: 238 RERKKRDEEKAKLRKLKEKEELETGKKDQSKQ-KESQRKFEEETVKSKVTVDTGVIPASE 296
Query: 166 -EAEVATEKEGE-DGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQ--------EEE 215
+AE T E + +GD+ K K K E E P AT + +Q EEE
Sbjct: 297 EKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEE 356
Query: 216 EQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEE 247
Q + K L RK + E ++ E
Sbjct: 357 RQKREEEERIKRLEELEAKRKEEERLEQEKRE 388
Score = 46.2 bits (108), Expect = 1e-04
Identities = 57/251 (22%), Positives = 98/251 (39%), Gaps = 25/251 (9%)
Query: 12 KKEGKAKKPEKEASNSSRETEPPPKAALKEWNG----VVSESDSPVKRP------GRKAA 61
+++ + KK K + S RE +A LK V S+ P KRP +K
Sbjct: 396 ERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIP 455
Query: 62 RVLGS-EGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK 120
+ L S E E E + + + + + +PP E + + ++ S
Sbjct: 456 QQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEET 515
Query: 121 RRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ 180
+ ++ + EE+ E+E+ E + EEEEEE + +E + EK ++ D
Sbjct: 516 EKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDS 575
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVK 240
T K K SK E+++ E ++++TK R K R+
Sbjct: 576 GKTLDK--KPSK-----------EMSSDSEYDSDDDRTKEERAYDKA-KRRIEKRRLEHS 621
Query: 241 KEVKEEEPGAP 251
K V E+ AP
Sbjct: 622 KNVNTEKLRAP 632
Score = 44.3 bits (103), Expect = 5e-04
Identities = 48/247 (19%), Positives = 105/247 (42%), Gaps = 18/247 (7%)
Query: 18 KKPEKEASNSSRETEPPP-KAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALS 76
KK + + S R+ E K+ + GV+ S+ + P A +EG+++ +
Sbjct: 263 KKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETP---TAAEDDNEGDKKKKDKK 319
Query: 77 PAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEV 136
KG+K + + P AT +L+ + ++R +++ + E
Sbjct: 320 KKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEER-----QKREEEERIKRLEELEA 374
Query: 137 LEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETP 196
++ E ++E + +K+++E+E + E ++ T+ + E + K L+ E P
Sbjct: 375 KRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP 434
Query: 197 TESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGA 256
S+ + K+ + E++++ ++ P+ L S + V+ E G P KE
Sbjct: 435 ----SKDSLPKKRPIYEDKKR----KKIPQQLESKEVSESMELCAAVEVMEQGVPEKE-E 485
Query: 257 AEGPLDP 263
P++P
Sbjct: 486 TPPPVEP 492
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/269 (24%), Positives = 108/269 (40%), Gaps = 46/269 (17%)
Query: 11 PKKEGKAKKPEKEASNSSRETEPPPKAAL------------KEWNGVVSESDSPVKRPGR 58
P +E ++ + S ++ P KAA+ K+ S+SDS G
Sbjct: 184 PSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGA 243
Query: 59 KAARVL-----------GSEGEEEDEALSPAKGQKPA---LDCSQVSPPRPATSPENNAS 104
K V S + + P +G+KPA L + P+P P +++S
Sbjct: 244 KPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSS 303
Query: 105 LSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESL 164
SD+ +D + R++L R +E ++E+ R++E+EE+E +E
Sbjct: 304 DSDSDEVDRISEWKRRDEARRRELEARRRRE------QEEELRRLREQEKEEKERRRERA 357
Query: 165 TEAEVATEKEGEDGDQPTTPPKPLKTSKAE-----TPTESVSEPEVATKQELQEEEEQTK 219
E G GD+ +P+K + P+ S SEPE E E + K
Sbjct: 358 DRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEA-------ELEREAK 410
Query: 220 PPRRAPKTLSSFFTPRKPAVK-KEVKEEE 247
+ P++ SS RKP K K V+ EE
Sbjct: 411 KSAKKPQS-SSTEPARKPGQKEKRVRPEE 438
Score = 40.4 bits (93), Expect = 0.008
Identities = 45/210 (21%), Positives = 79/210 (37%), Gaps = 18/210 (8%)
Query: 11 PKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEE 70
PK G+ KPE+ S+SS +++ + EW + +R +A R E+
Sbjct: 285 PKPRGRKPKPERPPSSSSSDSDSDEVDRISEW-----KRRDEARRRELEARR----RREQ 335
Query: 71 EDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPK 130
E+E + +K + + R + S D D P R+ + P
Sbjct: 336 EEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPS 395
Query: 131 RTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKT 190
+ E E + + AK+ + E K E V E++ + KP+K
Sbjct: 396 SSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQ--------AKPVKV 447
Query: 191 SKAETPTESVS-EPEVATKQELQEEEEQTK 219
+ +E S + +V K+E EE+ K
Sbjct: 448 ERTRKRSEGFSMDRKVEKKKEPSVEEKLQK 477
Score = 38.1 bits (87), Expect = 0.038
Identities = 63/275 (22%), Positives = 103/275 (37%), Gaps = 35/275 (12%)
Query: 21 EKEASNSSRETEPPPKAALKEWNGVVS-----ESDSPVKRPGRKA-ARVLGSEGEEEDEA 74
E+E R E + + +G S E D PVK+ GRK R S + E EA
Sbjct: 344 EQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEA 403
Query: 75 LSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQ 134
+ +K A Q S PA P + R KQ K
Sbjct: 404 ELEREAKKSAKK-PQSSSTEPARKPGQKEK---------------RVRPEEKQQAKPVKV 447
Query: 135 EVLEEQSE--DEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSK 192
E ++SE DR+ ++KKE EE ++ +E + A + + D + + L T +
Sbjct: 448 ERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQ 507
Query: 193 AETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTL----SSFFTPRKPAVKK------- 241
+ + VAT ++++ + +A + S P+ AV+K
Sbjct: 508 VTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME 567
Query: 242 EVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPV 276
+ K EE A + E P + + P+ + PV
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPV 602
Score = 32.7 bits (73), Expect = 1.6
Identities = 30/125 (24%), Positives = 51/125 (40%), Gaps = 26/125 (20%)
Query: 628 EKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFV 687
EK+Q +P +V TRKR E G S+ R+ ++ + E
Sbjct: 438 EKQQAKPVKVERTRKRSE---------------------GFSMDRKVEKKKEPSVEEKLQ 476
Query: 688 ETEGEFVFATSLDTKDIEQIAEFLEQ-SVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLK 746
+ E FA +D+ D+++ LE+ ++ K DV AT + +R K
Sbjct: 477 KLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRR----YKAN 532
Query: 747 KDYLD 751
KD ++
Sbjct: 533 KDVME 537
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 61.2 bits (147), Expect = 4e-09
Identities = 66/269 (24%), Positives = 108/269 (40%), Gaps = 46/269 (17%)
Query: 11 PKKEGKAKKPEKEASNSSRETEPPPKAAL------------KEWNGVVSESDSPVKRPGR 58
P +E ++ + S ++ P KAA+ K+ S+SDS G
Sbjct: 184 PSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADSDGA 243
Query: 59 KAARVL-----------GSEGEEEDEALSPAKGQKPA---LDCSQVSPPRPATSPENNAS 104
K V S + + P +G+KPA L + P+P P +++S
Sbjct: 244 KPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSS 303
Query: 105 LSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESL 164
SD+ +D + R++L R +E ++E+ R++E+EE+E +E
Sbjct: 304 DSDSDEVDRISEWKRRDEARRRELEARRRRE------QEEELRRLREQEKEEKERRRERA 357
Query: 165 TEAEVATEKEGEDGDQPTTPPKPLKTSKAE-----TPTESVSEPEVATKQELQEEEEQTK 219
E G GD+ +P+K + P+ S SEPE E E + K
Sbjct: 358 DRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEA-------ELEREAK 410
Query: 220 PPRRAPKTLSSFFTPRKPAVK-KEVKEEE 247
+ P++ SS RKP K K V+ EE
Sbjct: 411 KSAKKPQS-SSTEPARKPGQKEKRVRPEE 438
Score = 40.4 bits (93), Expect = 0.008
Identities = 45/210 (21%), Positives = 79/210 (37%), Gaps = 18/210 (8%)
Query: 11 PKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEE 70
PK G+ KPE+ S+SS +++ + EW + +R +A R E+
Sbjct: 285 PKPRGRKPKPERPPSSSSSDSDSDEVDRISEW-----KRRDEARRRELEARR----RREQ 335
Query: 71 EDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPK 130
E+E + +K + + R + S D D P R+ + P
Sbjct: 336 EEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPS 395
Query: 131 RTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKT 190
+ E E + + AK+ + E K E V E++ + KP+K
Sbjct: 396 SSDSEPEAELEREAKKSAKKPQSSSTEPARKPGQKEKRVRPEEKQQ--------AKPVKV 447
Query: 191 SKAETPTESVS-EPEVATKQELQEEEEQTK 219
+ +E S + +V K+E EE+ K
Sbjct: 448 ERTRKRSEGFSMDRKVEKKKEPSVEEKLQK 477
Score = 38.1 bits (87), Expect = 0.038
Identities = 63/275 (22%), Positives = 103/275 (37%), Gaps = 35/275 (12%)
Query: 21 EKEASNSSRETEPPPKAALKEWNGVVS-----ESDSPVKRPGRKA-ARVLGSEGEEEDEA 74
E+E R E + + +G S E D PVK+ GRK R S + E EA
Sbjct: 344 EQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEA 403
Query: 75 LSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQ 134
+ +K A Q S PA P + R KQ K
Sbjct: 404 ELEREAKKSAKK-PQSSSTEPARKPGQKEK---------------RVRPEEKQQAKPVKV 447
Query: 135 EVLEEQSE--DEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSK 192
E ++SE DR+ ++KKE EE ++ +E + A + + D + + L T +
Sbjct: 448 ERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQ 507
Query: 193 AETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTL----SSFFTPRKPAVKK------- 241
+ + VAT ++++ + +A + S P+ AV+K
Sbjct: 508 VTSQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGME 567
Query: 242 EVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPV 276
+ K EE A + E P + + P+ + PV
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPV 602
Score = 32.7 bits (73), Expect = 1.6
Identities = 30/125 (24%), Positives = 51/125 (40%), Gaps = 26/125 (20%)
Query: 628 EKKQIQPFQVLTTRKRKEVDASEIQVQVCLYAFDLIYLNGESLVREPLSRRRQLLRENFV 687
EK+Q +P +V TRKR E G S+ R+ ++ + E
Sbjct: 438 EKQQAKPVKVERTRKRSE---------------------GFSMDRKVEKKKEPSVEEKLQ 476
Query: 688 ETEGEFVFATSLDTKDIEQIAEFLEQ-SVKDSCEGLMVKTLDVDATYEIAKRSHNWLKLK 746
+ E FA +D+ D+++ LE+ ++ K DV AT + +R K
Sbjct: 477 KLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRR----YKAN 532
Query: 747 KDYLD 751
KD ++
Sbjct: 533 KDVME 537
>gi|157266334 tubby like protein 1 [Homo sapiens]
Length = 542
Score = 57.8 bits (138), Expect = 5e-08
Identities = 69/273 (25%), Positives = 102/273 (37%), Gaps = 61/273 (22%)
Query: 63 VLGSEGEEEDEALSPA------------------KGQKPALDCSQVSPPRPATSPENNAS 104
V S+ E+E+LSP + + P C S PR +
Sbjct: 11 VWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGAGRTGRP 70
Query: 105 LSDTSPMDSSPSGIPKRRTAR--------KQLPKRTIQEVLEEQSEDEDREAKRKKEEEE 156
+ SP D + + P+ AR K+ P+ T +EDE+ E + +E+EE
Sbjct: 71 REEPSP-DPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEEEEEDEEDEE 129
Query: 157 EET----------PKESLTEAEVATEKE------GEDGD--QPTTPPKPLKTSKAETPT- 197
EE PK+ L E A KE G GD P PPKPL+ E P
Sbjct: 130 EEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAG 189
Query: 198 ESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFF-----TPRKPAVKK----------E 242
E + K + +++ + P A K+ ++ F +P K A+KK E
Sbjct: 190 EGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEE 249
Query: 243 VKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHP 275
+EEE K+ +G G AK P
Sbjct: 250 EEEEEAATVIKKSNQKGKAKGKGKKKAKEERAP 282
Score = 39.3 bits (90), Expect = 0.017
Identities = 51/198 (25%), Positives = 74/198 (37%), Gaps = 32/198 (16%)
Query: 12 KKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEE 71
++E + E+EA + PPK L+E +S + +K KA G G
Sbjct: 120 EEEEDEEDEEEEAEEKKEKILLPPKKPLRE------KSSADLKERRAKAQGPRGDLG--- 170
Query: 72 DEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKR 131
SP KP ++ +P T + D PSG P +ARK
Sbjct: 171 ----SPDPPPKPLRVRNKEAPAGEGTKMRKTKK-KGSGEADKDPSGSPA--SARKS---P 220
Query: 132 TIQEVLEEQSEDEDREAKR------KKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPP 185
++ E S D+ K+ +KEEEEEE EA +K + G
Sbjct: 221 AAMFLVGEGSPDKKALKKKGTPKGARKEEEEEE-------EAATVIKKSNQKGKAKGKGK 273
Query: 186 KPLKTSKAETPTESVSEP 203
K K +A +P V EP
Sbjct: 274 KKAKEERAPSPPVEVDEP 291
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 57.4 bits (137), Expect = 6e-08
Identities = 62/275 (22%), Positives = 103/275 (37%), Gaps = 27/275 (9%)
Query: 12 KKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEE 71
+KE K + PE N E PPK KE V+ + D P+K + + +EE
Sbjct: 558 RKESKEETPEVTKVN---HVEKPPKVESKE--KVMVKKDKPIKTETKPSVTEKEVPSKEE 612
Query: 72 DEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKR 131
+ +K A D + E D P K+ A+K+ K
Sbjct: 613 PSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKP----KKEVAKKE-DKT 667
Query: 132 TIQEVLEEQSEDEDREAKRKKEEEEEETPKESL--------TEAEVATEKEGEDGDQPTT 183
I++ + + E+ +E K++ ++EE++ PK+ + + EV E++ E +
Sbjct: 668 PIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEEKE 727
Query: 184 PPKPLK-----TSKAETPTESVSEPEVATKQELQEEEEQTKPPRRA---PKTLSSFFTPR 235
P K +K K+ TP +P A K ++ ++EE K A PK +
Sbjct: 728 PKKEIKKLPKDAKKSSTPLSEAKKP-AALKPKVPKKEESVKKDSVAAGKPKEKGKIKVIK 786
Query: 236 KPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAK 270
K E G A + PAK
Sbjct: 787 KEGKAAEAVAAAVGTGATTAAVMAAAGIAAIGPAK 821
Score = 38.5 bits (88), Expect = 0.029
Identities = 61/265 (23%), Positives = 90/265 (33%), Gaps = 39/265 (14%)
Query: 21 EKEASNSSRETEPPPKAALK-----EWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEAL 75
E E + E EP K + E G E S KA E EE+ E
Sbjct: 902 EGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEESSETGDYEEKAETEEAEEPEEDGE-- 959
Query: 76 SPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQE 135
+ + S+ SP S + A +S SG + + ++ E
Sbjct: 960 -----EHVCVSASKHSPTEDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAE 1014
Query: 136 VLEEQSEDEDR-EAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQP----TTPPKPL-K 189
EE++++ED+ E R++E E E+ E A V E ++ TTP K L
Sbjct: 1015 QSEEEADEEDKAEDAREEEYEPEKMEAEDYVMAVVDKAAEAGGAEEQYGFLTTPTKQLGA 1074
Query: 190 TSKAETPTESV--------SEPEVATKQELQEEE------------EQTKPPRRAPKTLS 229
S P S+ SE E E E+ + T P +
Sbjct: 1075 QSPGREPASSIHDETLPGGSESEATASDEENREDQPEEFTATSGYTQSTIEISSEPTPMD 1134
Query: 230 SFFTPRKPAVKKEVKEEEPGAPGKE 254
TPR + E EE +P +E
Sbjct: 1135 EMSTPR-DVMSDETNNEETESPSQE 1158
Score = 37.4 bits (85), Expect = 0.065
Identities = 50/200 (25%), Positives = 84/200 (42%), Gaps = 36/200 (18%)
Query: 80 GQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEE 139
GQ P Q + A S E+ + P S R+ ++++ P+ T +E+
Sbjct: 523 GQVPTPVVKQTKLKQRADSRESLKPAAKPLPSKSV------RKESKEETPEVTKVNHVEK 576
Query: 140 QSEDEDREAKRKKEEEEEETP-KESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTE 198
+ E +E K+++ +T K S+TE EV +++E P P+K AE
Sbjct: 577 PPKVESKEKVMVKKDKPIKTETKPSVTEKEVPSKEE----------PSPVKAEVAEKQAT 626
Query: 199 SVSEPEVATKQELQEE---------EEQTKPPRRAPKTLSSFFTPRKPAVKK-EV----- 243
V +P+ A ++ +++E EE+ KP + K ++ KK EV
Sbjct: 627 DV-KPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKPKKEEVKKEVK 685
Query: 244 ---KEEEPGAPGKEGAAEGP 260
K+EE P KE E P
Sbjct: 686 KEIKKEEKKEPKKEVKKETP 705
Score = 32.7 bits (73), Expect = 1.6
Identities = 47/186 (25%), Positives = 67/186 (36%), Gaps = 19/186 (10%)
Query: 11 PKKEGK-----AKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLG 65
PKKE K AKK S + + PK KE V +S + K + +V+
Sbjct: 728 PKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKE-ESVKKDSVAAGKPKEKGKIKVIK 786
Query: 66 SEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTAR 125
EG+ EA++ A G + A P L + SSP + K
Sbjct: 787 KEGKAA-EAVAAAVGTGATTAAVMAAAGIAAIGPAKE--LEAERSLMSSPEDLTKDFEEL 843
Query: 126 KQLPKRTIQEVLEEQSEDEDREAKRK----------KEEEEEETPKESLTEAEVATEKEG 175
K +++ + ED E ++ KE E + P ES E TE EG
Sbjct: 844 KAEEVDVTKDIKPQLELIEDEEKLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEG 903
Query: 176 EDGDQP 181
E P
Sbjct: 904 ECEQTP 909
Score = 32.3 bits (72), Expect = 2.1
Identities = 50/229 (21%), Positives = 90/229 (39%), Gaps = 28/229 (12%)
Query: 11 PKKEGKAKKP--------EKEASNSSRETEPPPKAALKEWNGVVSESDSPV---KRPGRK 59
PKKE K + P +KE ++ E PK +K+ +S +P+ K+P
Sbjct: 696 PKKEVKKETPPKEVKKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAAL 755
Query: 60 AARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIP 119
+V E + ++++ K ++ + A + T+ + +GI
Sbjct: 756 KPKVPKKEESVKKDSVAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATTAAVMAAAGIA 815
Query: 120 KRRTARKQLPKRTIQ----------EVLEEQSEDEDREAKRKKE-EEEEETPKESLTEAE 168
A++ +R++ E L+ + D ++ K + E E+EE KE+
Sbjct: 816 AIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEEKLKETEPVEA 875
Query: 169 VATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQ 217
+KE E P P + T TE E E T +EL+ E+Q
Sbjct: 876 YVIQKEREVTKGPAESP-----DEGITTTEGEGECE-QTPEELEPVEKQ 918
Score = 31.2 bits (69), Expect = 4.6
Identities = 35/179 (19%), Positives = 61/179 (34%), Gaps = 10/179 (5%)
Query: 95 PATSPENNA--SLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKK 152
P S + N L +D + ++ Q+P +++ +Q D K
Sbjct: 490 PGNSTQYNILEGLEKLKHLDFLKQPLATQKDLTGQVPTPVVKQTKLKQRADSRESLKPAA 549
Query: 153 EEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQ 212
+ ++ ++ E K P K K + P ++ ++P V K+
Sbjct: 550 KPLPSKSVRKESKEETPEVTKVNHVEKPPKVESKEKVMVKKDKPIKTETKPSVTEKEVPS 609
Query: 213 EEEEQTKPPRRA--------PKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDP 263
+EE A PK ++ VK E K+EE P KE A + P
Sbjct: 610 KEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKVKPEDKKEEKEKPKKEVAKKEDKTP 668
Score = 30.8 bits (68), Expect = 6.1
Identities = 50/215 (23%), Positives = 84/215 (39%), Gaps = 43/215 (20%)
Query: 13 KEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEED 72
++G+A++ E+EA + + A +E+ E++ V KAA G+E E+
Sbjct: 1009 EKGEAEQSEEEADEEDKAED----AREEEYEPEKMEAEDYVMAVVDKAAEAGGAE-EQYG 1063
Query: 73 EALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRT 132
+P K Q+ P P + S+ D ++ P G TA
Sbjct: 1064 FLTTPTK---------QLGAQSPGREPAS--SIHD----ETLPGGSESEATA-------- 1100
Query: 133 IQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSK 192
S++E+RE ++ EE T T++ + E D+ +TP +
Sbjct: 1101 --------SDEENRE-----DQPEEFTATSGYTQSTIEISSEPTPMDEMSTPRDVMSDET 1147
Query: 193 AETPTESVSEPEV-ATKQELQ-EEEEQTKPPRRAP 225
TES S+ V TK E +E +KP P
Sbjct: 1148 NNEETESPSQEFVNITKYESSLYSQEYSKPADVTP 1182
>gi|58082089 hypothetical protein LOC161394 [Homo sapiens]
Length = 674
Score = 57.0 bits (136), Expect = 8e-08
Identities = 78/300 (26%), Positives = 123/300 (41%), Gaps = 38/300 (12%)
Query: 7 SFFHPKKEGKAKKPEKEASNSSRETEP---PPKAALKEWNGV-VSESDSPV----KRPG- 57
S P +E K E S+ ET+P PP + E +G V E + + PG
Sbjct: 133 SDLEPPEEAKPNVTEDVFLESAMETDPDPVPPTETMSEVSGATVRERNLELLEEETEPGV 192
Query: 58 -RKAARV----LGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMD 112
++ RV G E E+ + P++ +L+ + + PP+ T PE +P +
Sbjct: 193 PEESLRVQHEETGLEPPEQTKQDFPSEKLGESLEETDLQPPK-MTKPE--------TPEE 243
Query: 113 SSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEE-ETPKESLTEAEVAT 171
+ K+RT + P++ E LE++ EA + EE + E P+E +A T
Sbjct: 244 TQRESTEKKRT---EPPEQARLEFLEKEPRKSSEEAGLEPPEETQPEVPEEMQRKA---T 297
Query: 172 EKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSF 231
E++G + + T P P + T E+V EP K E EEE + K S
Sbjct: 298 EEKGTELPERTKPDFPDHKPRKSTD-ENVPEPLEEIKLEFPEEESR-KTNEETILEQSEM 355
Query: 232 FTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNP---AKNNYHPVEDACWKPGQKVP 288
P P ++ E++ P +E GP+ P NP K P E P + P
Sbjct: 356 MKPESPEEIRKSNEKKNPQPPEE---TGPVLPQEINPQVEEKTQTKPTEKILELPDETKP 412
Score = 50.1 bits (118), Expect = 1e-05
Identities = 61/255 (23%), Positives = 108/255 (42%), Gaps = 34/255 (13%)
Query: 11 PKKEGKAKKPEK--EASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEG 68
P K K + PE+ S + TEPP +A L+ +++ RK++ G E
Sbjct: 232 PPKMTKPETPEETQRESTEKKRTEPPEQARLEF-----------LEKEPRKSSEEAGLEP 280
Query: 69 EEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARK-- 126
EE + P + Q+ A + P T P+ D P S+ +P+ K
Sbjct: 281 PEETQPEVPEEMQRKATEEKGTELPE-RTKPD----FPDHKPRKSTDENVPEPLEEIKLE 335
Query: 127 ---QLPKRTIQEVLEEQSE----DEDREAKRKKEEEEEETPKES--LTEAEVATEKEGED 177
+ ++T +E + EQSE + E ++ E++ + P+E+ + E+ + E +
Sbjct: 336 FPEEESRKTNEETILEQSEMMKPESPEEIRKSNEKKNPQPPEETGPVLPQEINPQVEEKT 395
Query: 178 GDQPTTP--PKPLKTSKAETPTESVSE--PE-VATKQELQEEEEQTKPPRRAPKTLSSFF 232
+PT P +T ET E E PE + +K + +E + + P+R +LS F
Sbjct: 396 QTKPTEKILELPDETKPRETHVEFSKEDRPEPIKSKYSVGNDELEHREPKRGKLSLSDKF 455
Query: 233 TPRKPAVKKEVKEEE 247
A+ + EE
Sbjct: 456 RKEYYALGSLRESEE 470
>gi|31377595 zinc finger CCCH-type containing 18 [Homo sapiens]
Length = 953
Score = 54.7 bits (130), Expect = 4e-07
Identities = 66/320 (20%), Positives = 118/320 (36%), Gaps = 35/320 (10%)
Query: 12 KKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEE 71
+K K P +++ T P P+ + P + P R+ R L G
Sbjct: 634 EKSVKKPAPPPAPPQATKTTAPVPEPTKPGDPREARRKERPARTPPRR--RTLSGSGSGS 691
Query: 72 DEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKR 131
+ S + + +L S VS ATS ++A D+ M + + ++R P +
Sbjct: 692 GSSYSGSSSRSRSLSVSSVSSVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQ 751
Query: 132 TIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTS 191
T +E + + ED +E KRK+ + + PK + A G+ QP+TP +
Sbjct: 752 TRKEKGKSKKEDGVKEEKRKR-DSSTQPPKSAKPPA------GGKSSQQPSTPQQAPPGQ 804
Query: 192 KAE-----------TPTESVSEPEVATKQELQEEEEQTKPPRRAPKT----------LSS 230
+ T ++ + E +++ Q+ PP + P T
Sbjct: 805 PQQGTFVAHKEIKLTLLNKAADKGSRKRYEPSDKDRQSPPPAKRPNTSPDRGSRDRKSGG 864
Query: 231 FFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYL 290
KP ++ + P AP + L P + +K P + + PG
Sbjct: 865 RLGSPKPERQRGQNSKAPAAPADR---KRQLSPQSKSSSKVTSVPGKAS--DPGAASTKS 919
Query: 291 AVARTFEKIEEVSARLRMVE 310
A T + EE+ +L+ VE
Sbjct: 920 GKASTLSRREELLKQLKAVE 939
Score = 40.8 bits (94), Expect = 0.006
Identities = 43/178 (24%), Positives = 74/178 (41%), Gaps = 25/178 (14%)
Query: 91 SPPRPATSPENNAS---LSDT-------SPMDSSPSGIPKRRTARKQLPKR-TIQEVLEE 139
SP R SPE+ LSD S D +G+ ++ R QE +
Sbjct: 6 SPERDPHSPEDEEQPQGLSDDDILRDSGSDQDLDGAGVRASDLEDEESAARGPSQEEEDN 65
Query: 140 QSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTES 199
S++EDR ++ K ++++ E + S E+EG++G++ T +A + T
Sbjct: 66 HSDEEDRASEPKSQDQDSEVNELSRGPTSSPCEEEGDEGEEDRTSD---LRDEASSVTRE 122
Query: 200 VSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAA 257
+ E E+ +E+ EE A K A ++ +E+ G P +EG A
Sbjct: 123 LDEHELDYDEEVPEEPAPAVQEDEAEK-----------AGAEDDEEKGEGTPREEGKA 169
Score = 38.5 bits (88), Expect = 0.029
Identities = 26/110 (23%), Positives = 52/110 (47%), Gaps = 6/110 (5%)
Query: 120 KRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPK-----ESLTEAEVATEKE 174
+R R + +R +E E+ + D+E +R+KEE E E K + + E+E
Sbjct: 418 ERERERDRERERRQREREREREHERDKERQRRKEEWERERAKRDEKDRQHRDRDREKERE 477
Query: 175 GEDG-DQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRR 223
E G +P +P P + ++ + + P+V E ++ ++K P++
Sbjct: 478 KEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKK 527
Score = 38.5 bits (88), Expect = 0.029
Identities = 49/234 (20%), Positives = 84/234 (35%), Gaps = 49/234 (20%)
Query: 12 KKEGKAKKPEKEASNSSRETEPPPKAA---------LKEWNGVVSESDSPVKRPGRKAAR 62
+++ K K + SR+ EPP K A EW S SP K+ G
Sbjct: 476 REKEKGKPKPRSPQPPSRQAEPPKKEAATTGPQVKRADEWKDPWRRSKSPKKKLG----- 530
Query: 63 VLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRR 122
++SP++ ++ R TS ++AS S++S S S
Sbjct: 531 ----------VSVSPSRARR-----------RRKTS-ASSASASNSSRSSSRSSSYSGSG 568
Query: 123 TARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEA----EVATEKE---- 174
++R + + S R + +P S T + + T+ E
Sbjct: 569 SSRSRSRSSSYSSYSSRSSRHSSFSGSRSRSRSFSSSPSPSPTPSPHRPSIRTKGEPAPP 628
Query: 175 -GEDGD----QPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRR 223
G+ G+ +P PP P + +K P ++P + +E +T P RR
Sbjct: 629 PGKAGEKSVKKPAPPPAPPQATKTTAPVPEPTKPGDPREARRKERPARTPPRRR 682
Score = 32.7 bits (73), Expect = 1.6
Identities = 29/123 (23%), Positives = 49/123 (39%), Gaps = 24/123 (19%)
Query: 138 EEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPT 197
E ++ +RE +R+++ E E +E E E +KE + K E
Sbjct: 409 ERENRQRERERERERDRERERRQREREREREHERDKERQ-------------RRKEEWER 455
Query: 198 ESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAA 257
E E + ++ E++ + + PK PR P + ++ EP P KE A
Sbjct: 456 ERAKRDEKDRQHRDRDREKEREKEKGKPK-------PRSP--QPPSRQAEP--PKKEAAT 504
Query: 258 EGP 260
GP
Sbjct: 505 TGP 507
Score = 32.0 bits (71), Expect = 2.7
Identities = 39/215 (18%), Positives = 76/215 (35%), Gaps = 27/215 (12%)
Query: 47 SESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLS 106
S S SP P R + R G +A G+K S +PA P +
Sbjct: 605 SPSPSPTPSPHRPSIRTKGEPAPPPGKA-----GEK--------SVKKPAPPPAPPQATK 651
Query: 107 DTSPMDSSPSGIPKRRTARKQLP------KRTIQEVLEEQSEDEDREAKRKKEEEEEETP 160
T+P+ R RK+ P +RT+ + R +
Sbjct: 652 TTAPVPEPTKPGDPREARRKERPARTPPRRRTLSGSGSGSGSSYSGSSSRSRSLSVSSVS 711
Query: 161 KESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPT-------ESVSEPEVATKQELQE 213
S + ++ + D P+ ++ + +P + S+ E K+E ++
Sbjct: 712 SVSSATSSSSSAHSVDSEDMYADLASPVSSASSRSPAPAQTRKEKGKSKKEDGVKEEKRK 771
Query: 214 EEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEP 248
+ T+PP+ A K + + ++P+ ++ +P
Sbjct: 772 RDSSTQPPKSA-KPPAGGKSSQQPSTPQQAPPGQP 805
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 54.3 bits (129), Expect = 5e-07
Identities = 69/275 (25%), Positives = 103/275 (37%), Gaps = 38/275 (13%)
Query: 15 GKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDE- 73
G+A ++ S+SS ET+ K ++K V + S S + P RKAA G G+ +
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQ-VKASSVSTKESPARKAAPAPGKVGDVTPQV 252
Query: 74 ---ALSPAKGQK-------------------PALDCSQVSPP------RPATSPENNASL 105
AL PAK K PA SQV R A++P
Sbjct: 253 KGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG 312
Query: 106 SDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT 165
+P +G +T + P+ + EE S+ E+ K + + + K S
Sbjct: 313 KGATPAPPGKAGAVASQTKAGK-PEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQV 371
Query: 166 EAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEE---QTKPPR 222
A A KE PP + A+ E ++ +E EEE Q KP
Sbjct: 372 GAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Query: 223 RAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAA 257
+AP+ ++ PA + K P P K G A
Sbjct: 432 KAPQVRAA----SAPAKESPRKGAAPAPPRKTGPA 462
Score = 36.6 bits (83), Expect = 0.11
Identities = 68/287 (23%), Positives = 99/287 (34%), Gaps = 52/287 (18%)
Query: 16 KAKKPEKEASNSSRETEP----PPKAALK---EWNGVVSESDSPVKRPGRKAARVLGSEG 68
KA+ E A +SS E+E P L N V + P P A + G+
Sbjct: 986 KARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP---KASMAGASS 1042
Query: 69 EEEDEALSPAKGQK-PALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQ 127
+E +S K Q+ PA PATSP++ + + + P +P+ + A K
Sbjct: 1043 SKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPK-LPEVQQATK- 1100
Query: 128 LPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKP 187
E + ED EE+ E P+ + K PT P
Sbjct: 1101 --------APESSDDSEDSSDSSSGSEEDGEGPQGA---------KSAHTLVGPT--PSR 1141
Query: 188 LKTSKAETPTESVSEPEVATKQEL-------------QEEEEQTKPPRRAPKTLSSFFTP 234
+T ET ES + VA Q L + + T +P S+
Sbjct: 1142 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAK 1201
Query: 235 RKPAVKKEVKEEE------PGAPGKEGAAEGPLDPSGYNPAKNNYHP 275
P K+E K ++ P GKE AA G P K +P
Sbjct: 1202 DDPDGKQEAKPQQAAGMLSPKTGGKE-AASGTTPQKSRKPKKGAGNP 1247
Score = 33.1 bits (74), Expect = 1.2
Identities = 47/233 (20%), Positives = 81/233 (34%), Gaps = 27/233 (11%)
Query: 36 KAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAK---GQKPALDCSQVSP 92
KAA G + + +PV PG+ V + E+++++ S + ++ A +QV
Sbjct: 725 KAASVPVKGSLGQGTAPVL-PGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT 783
Query: 93 PRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKK 152
T + N + + + S K TA Q +R+ +V ++ +
Sbjct: 784 SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARG 843
Query: 153 EEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQ 212
K T A+ T E + G S E + +E
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSG----------------------SSEEESDSEEEA 881
Query: 213 EEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSG 265
E Q KP + + + + P K + +K PG G A G D SG
Sbjct: 882 ETLAQVKPSGKTHQ-IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Score = 33.1 bits (74), Expect = 1.2
Identities = 49/251 (19%), Positives = 92/251 (36%), Gaps = 22/251 (8%)
Query: 20 PEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLG-----SEGEEEDEA 74
P +NS P + + ++ D P + K + G + G+E
Sbjct: 1172 PGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1231
Query: 75 LSPAKGQKPALDCSQVSPPRPATSPENNAS---LSDTSPMDSSP--SGIPKRRTARKQLP 129
+P K +KP +P + ++N + L P++ + + + K T +
Sbjct: 1232 TTPQKSRKPKKGAG--NPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE 1289
Query: 130 KRTIQEVLEEQSED--EDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKP 187
++ + + +E S E R+ K ++ TP+ + A GE G+ +P K
Sbjct: 1290 RKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA----GEGGEASVSPEKT 1345
Query: 188 LKTSKAETPTESVS--EPEVATKQELQEEEEQTKPPRRAPKTLSSF--FTPRKPAVKKEV 243
TSK + + S E K L + + +P K + + P KKE
Sbjct: 1346 STTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEK 1405
Query: 244 KEEEPGAPGKE 254
K+ + KE
Sbjct: 1406 KKSDKRKKDKE 1416
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 54.3 bits (129), Expect = 5e-07
Identities = 69/275 (25%), Positives = 103/275 (37%), Gaps = 38/275 (13%)
Query: 15 GKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDE- 73
G+A ++ S+SS ET+ K ++K V + S S + P RKAA G G+ +
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQ-VKASSVSTKESPARKAAPAPGKVGDVTPQV 252
Query: 74 ---ALSPAKGQK-------------------PALDCSQVSPP------RPATSPENNASL 105
AL PAK K PA SQV R A++P
Sbjct: 253 KGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG 312
Query: 106 SDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT 165
+P +G +T + P+ + EE S+ E+ K + + + K S
Sbjct: 313 KGATPAPPGKAGAVASQTKAGK-PEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQV 371
Query: 166 EAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEE---QTKPPR 222
A A KE PP + A+ E ++ +E EEE Q KP
Sbjct: 372 GAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Query: 223 RAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAA 257
+AP+ ++ PA + K P P K G A
Sbjct: 432 KAPQVRAA----SAPAKESPRKGAAPAPPRKTGPA 462
Score = 35.8 bits (81), Expect = 0.19
Identities = 51/217 (23%), Positives = 75/217 (34%), Gaps = 38/217 (17%)
Query: 84 ALDCSQVSPPRPATSPENNA-----SLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLE 138
A S+ PP T P + +L TSP +S + + +LP+
Sbjct: 1081 AQKASEAQPPVARTQPSSGVDSAVGTLPATSPQSTSVQAKGTNKLRKPKLPEVQQATKAP 1140
Query: 139 EQSED-EDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPT 197
E S+D ED EE+ E P+ + + + PT P +T ET
Sbjct: 1141 ESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG----------PT--PSRTETLVEETAA 1188
Query: 198 ESVSEPEVATKQEL-------------QEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVK 244
ES + VA Q L + + T +P S+ P K+E K
Sbjct: 1189 ESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAK 1248
Query: 245 EEE------PGAPGKEGAAEGPLDPSGYNPAKNNYHP 275
++ P GKE AA G P K +P
Sbjct: 1249 PQQAAGMLSPKTGGKE-AASGTTPQKSRKPKKGAGNP 1284
Score = 33.1 bits (74), Expect = 1.2
Identities = 47/233 (20%), Positives = 81/233 (34%), Gaps = 27/233 (11%)
Query: 36 KAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAK---GQKPALDCSQVSP 92
KAA G + + +PV PG+ V + E+++++ S + ++ A +QV
Sbjct: 725 KAASVPVKGSLGQGTAPVL-PGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT 783
Query: 93 PRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKK 152
T + N + + + S K TA Q +R+ +V ++ +
Sbjct: 784 SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARG 843
Query: 153 EEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQ 212
K T A+ T E + G S E + +E
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSG----------------------SSEEESDSEEEA 881
Query: 213 EEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSG 265
E Q KP + + + + P K + +K PG G A G D SG
Sbjct: 882 ETLAQVKPSGKTHQ-IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Score = 33.1 bits (74), Expect = 1.2
Identities = 49/251 (19%), Positives = 92/251 (36%), Gaps = 22/251 (8%)
Query: 20 PEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLG-----SEGEEEDEA 74
P +NS P + + ++ D P + K + G + G+E
Sbjct: 1209 PGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1268
Query: 75 LSPAKGQKPALDCSQVSPPRPATSPENNAS---LSDTSPMDSSP--SGIPKRRTARKQLP 129
+P K +KP +P + ++N + L P++ + + + K T +
Sbjct: 1269 TTPQKSRKPKKGAG--NPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE 1326
Query: 130 KRTIQEVLEEQSED--EDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKP 187
++ + + +E S E R+ K ++ TP+ + A GE G+ +P K
Sbjct: 1327 RKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA----GEGGEASVSPEKT 1382
Query: 188 LKTSKAETPTESVS--EPEVATKQELQEEEEQTKPPRRAPKTLSSF--FTPRKPAVKKEV 243
TSK + + S E K L + + +P K + + P KKE
Sbjct: 1383 STTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEK 1442
Query: 244 KEEEPGAPGKE 254
K+ + KE
Sbjct: 1443 KKSDKRKKDKE 1453
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a
[Homo sapiens]
Length = 1450
Score = 54.3 bits (129), Expect = 5e-07
Identities = 69/275 (25%), Positives = 103/275 (37%), Gaps = 38/275 (13%)
Query: 15 GKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDE- 73
G+A ++ S+SS ET+ K ++K V + S S + P RKAA G G+ +
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQ-VKASSVSTKESPARKAAPAPGKVGDVTPQV 252
Query: 74 ---ALSPAKGQK-------------------PALDCSQVSPP------RPATSPENNASL 105
AL PAK K PA SQV R A++P
Sbjct: 253 KGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG 312
Query: 106 SDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT 165
+P +G +T + P+ + EE S+ E+ K + + + K S
Sbjct: 313 KGATPAPPGKAGAVASQTKAGK-PEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQV 371
Query: 166 EAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEE---QTKPPR 222
A A KE PP + A+ E ++ +E EEE Q KP
Sbjct: 372 GAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Query: 223 RAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAA 257
+AP+ ++ PA + K P P K G A
Sbjct: 432 KAPQVRAA----SAPAKESPRKGAAPAPPRKTGPA 462
Score = 36.6 bits (83), Expect = 0.11
Identities = 67/287 (23%), Positives = 100/287 (34%), Gaps = 53/287 (18%)
Query: 16 KAKKPEKEASNSSRETEP----PPKAALK---EWNGVVSESDSPVKRPGRKAARVLGSEG 68
KA+ E A +SS E+E P L N V + P P A + G+
Sbjct: 986 KARASESTARSSSSESEDEDVIPATQCLTPGIRTNVVTMPTAHPRIAP---KASMAGASS 1042
Query: 69 EEEDEALSPAKGQK-PALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQ 127
+E +S K Q+ PA PATSP++ + + + P +P+ + A K
Sbjct: 1043 SKESSRISDGKKQEGPATQVDSAVGTLPATSPQSTSVQAKGTNKLRKPK-LPEVQQATK- 1100
Query: 128 LPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKP 187
E + ED EE+ E P+ + + + PT P
Sbjct: 1101 --------APESSDDSEDSSDSSSGSEEDGEGPQGAKSAHTLG----------PT--PSR 1140
Query: 188 LKTSKAETPTESVSEPEVATKQEL-------------QEEEEQTKPPRRAPKTLSSFFTP 234
+T ET ES + VA Q L + + T +P S+
Sbjct: 1141 TETLVEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPKLDSSPSVSSTLAAK 1200
Query: 235 RKPAVKKEVKEEE------PGAPGKEGAAEGPLDPSGYNPAKNNYHP 275
P K+E K ++ P GKE AA G P K +P
Sbjct: 1201 DDPDGKQEAKPQQAAGMLSPKTGGKE-AASGTTPQKSRKPKKGAGNP 1246
Score = 33.1 bits (74), Expect = 1.2
Identities = 47/233 (20%), Positives = 81/233 (34%), Gaps = 27/233 (11%)
Query: 36 KAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAK---GQKPALDCSQVSP 92
KAA G + + +PV PG+ V + E+++++ S + ++ A +QV
Sbjct: 725 KAASVPVKGSLGQGTAPVL-PGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT 783
Query: 93 PRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKK 152
T + N + + + S K TA Q +R+ +V ++ +
Sbjct: 784 SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARG 843
Query: 153 EEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQ 212
K T A+ T E + G S E + +E
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSG----------------------SSEEESDSEEEA 881
Query: 213 EEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSG 265
E Q KP + + + + P K + +K PG G A G D SG
Sbjct: 882 ETLAQVKPSGKTHQ-IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
Score = 33.1 bits (74), Expect = 1.2
Identities = 49/251 (19%), Positives = 92/251 (36%), Gaps = 22/251 (8%)
Query: 20 PEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLG-----SEGEEEDEA 74
P +NS P + + ++ D P + K + G + G+E
Sbjct: 1171 PGLTPANSQASKATPKLDSSPSVSSTLAAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASG 1230
Query: 75 LSPAKGQKPALDCSQVSPPRPATSPENNAS---LSDTSPMDSSP--SGIPKRRTARKQLP 129
+P K +KP +P + ++N + L P++ + + + K T +
Sbjct: 1231 TTPQKSRKPKKGAG--NPQASTLALQSNITQCLLGQPWPLNEAQVQASVVKVLTELLEQE 1288
Query: 130 KRTIQEVLEEQSED--EDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKP 187
++ + + +E S E R+ K ++ TP+ + A GE G+ +P K
Sbjct: 1289 RKKVVDTTKESSRKGWESRKRKLSGDQPAARTPRSKKKKKLGA----GEGGEASVSPEKT 1344
Query: 188 LKTSKAETPTESVS--EPEVATKQELQEEEEQTKPPRRAPKTLSSF--FTPRKPAVKKEV 243
TSK + + S E K L + + +P K + + P KKE
Sbjct: 1345 STTSKGKAKRDKASGDVKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEK 1404
Query: 244 KEEEPGAPGKE 254
K+ + KE
Sbjct: 1405 KKSDKRKKDKE 1415
>gi|57164979 Treacher Collins-Franceschetti syndrome 1 isoform c
[Homo sapiens]
Length = 958
Score = 54.3 bits (129), Expect = 5e-07
Identities = 69/275 (25%), Positives = 103/275 (37%), Gaps = 38/275 (13%)
Query: 15 GKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDE- 73
G+A ++ S+SS ET+ K ++K V + S S + P RKAA G G+ +
Sbjct: 194 GQADSSSEDTSSSSDETDVEGKPSVKPAQ-VKASSVSTKESPARKAAPAPGKVGDVTPQV 252
Query: 74 ---ALSPAKGQK-------------------PALDCSQVSPP------RPATSPENNASL 105
AL PAK K PA SQV R A++P
Sbjct: 253 KGGALPPAKRAKKPEEESESSEEGSESEEEAPAGTRSQVKASEKILQVRAASAPAKGTPG 312
Query: 106 SDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT 165
+P +G +T + P+ + EE S+ E+ K + + + K S
Sbjct: 313 KGATPAPPGKAGAVASQTKAGK-PEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQV 371
Query: 166 EAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEE---QTKPPR 222
A A KE PP + A+ E ++ +E EEE Q KP
Sbjct: 372 GAASAPAKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSG 431
Query: 223 RAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAA 257
+AP+ ++ PA + K P P K G A
Sbjct: 432 KAPQVRAA----SAPAKESPRKGAAPAPPRKTGPA 462
Score = 33.1 bits (74), Expect = 1.2
Identities = 47/233 (20%), Positives = 81/233 (34%), Gaps = 27/233 (11%)
Query: 36 KAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAK---GQKPALDCSQVSP 92
KAA G + + +PV PG+ V + E+++++ S + ++ A +QV
Sbjct: 725 KAASVPVKGSLGQGTAPVL-PGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKT 783
Query: 93 PRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKK 152
T + N + + + S K TA Q +R+ +V ++ +
Sbjct: 784 SVKKTQAKANPAAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARG 843
Query: 153 EEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQ 212
K T A+ T E + G S E + +E
Sbjct: 844 PASVPSVGKAVATAAQAQTGPEEDSG----------------------SSEEESDSEEEA 881
Query: 213 EEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSG 265
E Q KP + + + + P K + +K PG G A G D SG
Sbjct: 882 ETLAQVKPSGKTHQ-IRAALAPAKESPRKGAAPTPPGKTGPSAAQAGKQDDSG 933
>gi|148727245 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 52.0 bits (123), Expect = 3e-06
Identities = 73/314 (23%), Positives = 129/314 (41%), Gaps = 30/314 (9%)
Query: 13 KEGKAKKPEKEASNSSRETEPPP-KAALKEWNGVVSESDSPVKRP--GRKA-ARVLGSEG 68
KEG K +E S +E P + A++ G + +S + +P G A V S+
Sbjct: 108 KEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQP 167
Query: 69 EEED------EALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRR 122
+E D E + P +G P S P +P AS+ + P + S P+
Sbjct: 168 KESDIPKSPEETIQPKEGDIPK---SSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEA 224
Query: 123 TARKQ--LPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ 180
K+ LPK +++E ++ +E K EE PKE + + ++GD
Sbjct: 225 IQPKEGDLPK-SLEEAIQP------KEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDI 277
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRA--PKTLSSFFTPRKPA 238
P +P + ++ K + P +S E + ++ + +Q P+ PK+L P++
Sbjct: 278 PKSPEETIQPKKGDIP-KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEID 336
Query: 239 VKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKP-GQKVPYLAVARTFE 297
+ K +E KE + L+ + + + P E+ P G KV + FE
Sbjct: 337 IPKSPEET---IQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFE 393
Query: 298 -KIEEVSARLRMVE 310
++E RL V+
Sbjct: 394 ASLKEAGERLVAVD 407
Score = 42.4 bits (98), Expect = 0.002
Identities = 52/254 (20%), Positives = 96/254 (37%), Gaps = 42/254 (16%)
Query: 23 EASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQK 82
E S++S+E + PK++ + + DSP K G + +E + K
Sbjct: 11 EESDASQEGDDLPKSSANTSHP--KQDDSP-KSSEETIQPKEGDIPKAPEETIQSKKEDL 67
Query: 83 PALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQ-----LPKRTIQEVL 137
P + P E+N S P+ IPK Q +PK +E +
Sbjct: 68 PKSSEKAIQPK------ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAP-EETI 120
Query: 138 EEQSEDEDREAKRKKEEEEEETPKESL------------TEAEVATEKEGE--------- 176
+ + ED + ++ + +E + PK S T + + KE +
Sbjct: 121 QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI 180
Query: 177 ---DGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRA--PKTLSSF 231
+GD P + KP++ P SV +P + ++ + E+ P+ PK+L
Sbjct: 181 QPKEGDIPKSSAKPIQPKLGNIPKASV-KPSQPKEGDISKSPEEAIQPKEGDLPKSLEEA 239
Query: 232 FTPRKPAVKKEVKE 245
P++ + K +E
Sbjct: 240 IQPKEGDIPKSPEE 253
Score = 30.4 bits (67), Expect = 7.9
Identities = 41/195 (21%), Positives = 76/195 (38%), Gaps = 33/195 (16%)
Query: 108 TSPMDSSPSG--IPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT 165
T D+S G +PK +A PK ++ S E + KE + + P+E++
Sbjct: 10 TEESDASQEGDDLPKS-SANTSHPK-------QDDSPKSSEETIQPKEGDIPKAPEETIQ 61
Query: 166 EAEVATEKEGEDGDQ------PTTPPKPLKTSKAETPTESV--SEPE------------V 205
+ K E Q P + KP++ P SV S+P+
Sbjct: 62 SKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQ 121
Query: 206 ATKQELQEEEEQTKPPRRA--PKTLSSFFTPRKPAV-KKEVKEEEPGAPGKEGAAEGPLD 262
+ K++L + E+ P+ PK+ + P+ + K VK +P + E +
Sbjct: 122 SKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQ 181
Query: 263 PSGYNPAKNNYHPVE 277
P + K++ P++
Sbjct: 182 PKEGDIPKSSAKPIQ 196
>gi|148727319 thioredoxin domain-containing 2 isoform 2 [Homo
sapiens]
Length = 553
Score = 52.0 bits (123), Expect = 3e-06
Identities = 73/314 (23%), Positives = 129/314 (41%), Gaps = 30/314 (9%)
Query: 13 KEGKAKKPEKEASNSSRETEPPP-KAALKEWNGVVSESDSPVKRP--GRKA-ARVLGSEG 68
KEG K +E S +E P + A++ G + +S + +P G A V S+
Sbjct: 175 KEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQP 234
Query: 69 EEED------EALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRR 122
+E D E + P +G P S P +P AS+ + P + S P+
Sbjct: 235 KESDIPKSPEETIQPKEGDIPK---SSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEA 291
Query: 123 TARKQ--LPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ 180
K+ LPK +++E ++ +E K EE PKE + + ++GD
Sbjct: 292 IQPKEGDLPK-SLEEAIQP------KEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDI 344
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRA--PKTLSSFFTPRKPA 238
P +P + ++ K + P +S E + ++ + +Q P+ PK+L P++
Sbjct: 345 PKSPEETIQPKKGDIP-KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEID 403
Query: 239 VKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKP-GQKVPYLAVARTFE 297
+ K +E KE + L+ + + + P E+ P G KV + FE
Sbjct: 404 IPKSPEET---IQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFE 460
Query: 298 -KIEEVSARLRMVE 310
++E RL V+
Sbjct: 461 ASLKEAGERLVAVD 474
Score = 42.4 bits (98), Expect = 0.002
Identities = 52/254 (20%), Positives = 96/254 (37%), Gaps = 42/254 (16%)
Query: 23 EASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQK 82
E S++S+E + PK++ + + DSP K G + +E + K
Sbjct: 78 EESDASQEGDDLPKSSANTSHP--KQDDSP-KSSEETIQPKEGDIPKAPEETIQSKKEDL 134
Query: 83 PALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQ-----LPKRTIQEVL 137
P + P E+N S P+ IPK Q +PK +E +
Sbjct: 135 PKSSEKAIQPK------ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAP-EETI 187
Query: 138 EEQSEDEDREAKRKKEEEEEETPKESL------------TEAEVATEKEGE--------- 176
+ + ED + ++ + +E + PK S T + + KE +
Sbjct: 188 QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI 247
Query: 177 ---DGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRA--PKTLSSF 231
+GD P + KP++ P SV +P + ++ + E+ P+ PK+L
Sbjct: 248 QPKEGDIPKSSAKPIQPKLGNIPKASV-KPSQPKEGDISKSPEEAIQPKEGDLPKSLEEA 306
Query: 232 FTPRKPAVKKEVKE 245
P++ + K +E
Sbjct: 307 IQPKEGDIPKSPEE 320
Score = 30.4 bits (67), Expect = 7.9
Identities = 41/195 (21%), Positives = 76/195 (38%), Gaps = 33/195 (16%)
Query: 108 TSPMDSSPSG--IPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT 165
T D+S G +PK +A PK ++ S E + KE + + P+E++
Sbjct: 77 TEESDASQEGDDLPKS-SANTSHPK-------QDDSPKSSEETIQPKEGDIPKAPEETIQ 128
Query: 166 EAEVATEKEGEDGDQ------PTTPPKPLKTSKAETPTESV--SEPE------------V 205
+ K E Q P + KP++ P SV S+P+
Sbjct: 129 SKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQ 188
Query: 206 ATKQELQEEEEQTKPPRRA--PKTLSSFFTPRKPAV-KKEVKEEEPGAPGKEGAAEGPLD 262
+ K++L + E+ P+ PK+ + P+ + K VK +P + E +
Sbjct: 189 SKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQ 248
Query: 263 PSGYNPAKNNYHPVE 277
P + K++ P++
Sbjct: 249 PKEGDIPKSSAKPIQ 263
>gi|42516570 thioredoxin domain-containing 2 isoform 1 [Homo
sapiens]
Length = 486
Score = 52.0 bits (123), Expect = 3e-06
Identities = 73/314 (23%), Positives = 129/314 (41%), Gaps = 30/314 (9%)
Query: 13 KEGKAKKPEKEASNSSRETEPPP-KAALKEWNGVVSESDSPVKRP--GRKA-ARVLGSEG 68
KEG K +E S +E P + A++ G + +S + +P G A V S+
Sbjct: 108 KEGDIPKAPEETIQSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQP 167
Query: 69 EEED------EALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRR 122
+E D E + P +G P S P +P AS+ + P + S P+
Sbjct: 168 KESDIPKSPEETIQPKEGDIPK---SSAKPIQPKLGNIPKASVKPSQPKEGDISKSPEEA 224
Query: 123 TARKQ--LPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQ 180
K+ LPK +++E ++ +E K EE PKE + + ++GD
Sbjct: 225 IQPKEGDLPK-SLEEAIQP------KEGDIPKSPEEAIQPKEGDIPKSLEEAIQPKEGDI 277
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRA--PKTLSSFFTPRKPA 238
P +P + ++ K + P +S E + ++ + +Q P+ PK+L P++
Sbjct: 278 PKSPEETIQPKKGDIP-KSPEEAIQPKEGDIPKSPKQAIQPKEGDIPKSLEEAIPPKEID 336
Query: 239 VKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKP-GQKVPYLAVARTFE 297
+ K +E KE + L+ + + + P E+ P G KV + FE
Sbjct: 337 IPKSPEET---IQPKEDDSPKSLEEATPSKEGDILKPEEETMEFPEGDKVKVILSKEDFE 393
Query: 298 -KIEEVSARLRMVE 310
++E RL V+
Sbjct: 394 ASLKEAGERLVAVD 407
Score = 42.4 bits (98), Expect = 0.002
Identities = 52/254 (20%), Positives = 96/254 (37%), Gaps = 42/254 (16%)
Query: 23 EASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQK 82
E S++S+E + PK++ + + DSP K G + +E + K
Sbjct: 11 EESDASQEGDDLPKSSANTSHP--KQDDSP-KSSEETIQPKEGDIPKAPEETIQSKKEDL 67
Query: 83 PALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQ-----LPKRTIQEVL 137
P + P E+N S P+ IPK Q +PK +E +
Sbjct: 68 PKSSEKAIQPK------ESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAP-EETI 120
Query: 138 EEQSEDEDREAKRKKEEEEEETPKESL------------TEAEVATEKEGE--------- 176
+ + ED + ++ + +E + PK S T + + KE +
Sbjct: 121 QSKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETI 180
Query: 177 ---DGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRA--PKTLSSF 231
+GD P + KP++ P SV +P + ++ + E+ P+ PK+L
Sbjct: 181 QPKEGDIPKSSAKPIQPKLGNIPKASV-KPSQPKEGDISKSPEEAIQPKEGDLPKSLEEA 239
Query: 232 FTPRKPAVKKEVKE 245
P++ + K +E
Sbjct: 240 IQPKEGDIPKSPEE 253
Score = 30.4 bits (67), Expect = 7.9
Identities = 41/195 (21%), Positives = 76/195 (38%), Gaps = 33/195 (16%)
Query: 108 TSPMDSSPSG--IPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT 165
T D+S G +PK +A PK ++ S E + KE + + P+E++
Sbjct: 10 TEESDASQEGDDLPKS-SANTSHPK-------QDDSPKSSEETIQPKEGDIPKAPEETIQ 61
Query: 166 EAEVATEKEGEDGDQ------PTTPPKPLKTSKAETPTESV--SEPE------------V 205
+ K E Q P + KP++ P SV S+P+
Sbjct: 62 SKKEDLPKSSEKAIQPKESNIPKSSAKPIQPKLGNIPKASVKPSQPKEGDIPKAPEETIQ 121
Query: 206 ATKQELQEEEEQTKPPRRA--PKTLSSFFTPRKPAV-KKEVKEEEPGAPGKEGAAEGPLD 262
+ K++L + E+ P+ PK+ + P+ + K VK +P + E +
Sbjct: 122 SKKEDLPKSSEEAIQPKEGDIPKSSAKPIQPKLGNIAKTSVKPSQPKESDIPKSPEETIQ 181
Query: 263 PSGYNPAKNNYHPVE 277
P + K++ P++
Sbjct: 182 PKEGDIPKSSAKPIQ 196
>gi|209977046 fibrous sheath CABYR binding protein [Homo sapiens]
Length = 825
Score = 52.0 bits (123), Expect = 3e-06
Identities = 74/306 (24%), Positives = 114/306 (37%), Gaps = 42/306 (13%)
Query: 11 PKKEGKAKKPEKEASNSSRETEP----PPKAALKEWNGVVSESDSPVKRPGRKAARVLGS 66
P E A+ A S E P PP A ++ E SP + + L +
Sbjct: 342 PSVELLAEILPPSAEESPSEEPPAEILPPPAEKSPSVELLGEIRSPSAQKAPIEVQPLPA 401
Query: 67 EGEEEDEALSPAKGQKPALD--CSQVSPPRPATSPENNA-----SLSDTSPMDSSP---- 115
EG E+ +PAK + P ++ + V P P +P A S + +P + +P
Sbjct: 402 EGALEE---APAKVEPPTVEETLADVQPLLPEEAPREEARELQLSTAMETPAEEAPTEFQ 458
Query: 116 SGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEE---------------EEETP 160
S +PK TA + + + E +++ EA+ EE EE T
Sbjct: 459 SPLPKETTAEEASAEIQLLAATEPPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTA 518
Query: 161 KESLTEAEVATEKEGEDGDQPTTPPKPL--KTSKAETPTESVSEPEVATKQELQEEEEQT 218
+E+ E ++ E + P PL +TS E P E V P A ++E +
Sbjct: 519 EEASAEIQLLAAIEAPADETPAEAQSPLSEETSAEEAPAE-VQSPS-AKGVSIEEAPLEL 576
Query: 219 KPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGA-----PGKEGAAEGPLDPSGYNPAKNNY 273
+PP T + E EE A P +E AE P+ PA+
Sbjct: 577 QPPSGEETTAEEASAAIQLLAATEASAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQP 636
Query: 274 HPVEDA 279
P E+A
Sbjct: 637 PPAEEA 642
Score = 35.4 bits (80), Expect = 0.25
Identities = 43/208 (20%), Positives = 72/208 (34%), Gaps = 21/208 (10%)
Query: 92 PPRPATSPENNASLSDTSPMDSS----PSGIPKRRTARKQLPKRTIQEVLEEQSEDEDRE 147
PP T E + LS+ + + + S + + TA + + + +E +++ E
Sbjct: 482 PPADETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAE 541
Query: 148 AKRKKEEEE--EETPKE-------SLTEAEVATEKEGEDGDQPTTPPKPL--------KT 190
A+ EE EE P E ++ E E + G++ T +
Sbjct: 542 AQSPLSEETSAEEAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEA 601
Query: 191 SKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGA 250
S E P E P E+Q + P P +P +E E
Sbjct: 602 SAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPP 661
Query: 251 PGKEGAAEGPLDPSGYNPAKNNYHPVED 278
P +E AE P+ PA+ P E+
Sbjct: 662 PAEEAPAEVQPPPAEEAPAEVQSLPAEE 689
Score = 31.6 bits (70), Expect = 3.6
Identities = 53/235 (22%), Positives = 80/235 (34%), Gaps = 27/235 (11%)
Query: 69 EEEDEALSPAKGQKPALDC-SQVSPP--RPATSPENNASLSDTSPMDSSPSGIPKRRTAR 125
E EA SP + A + ++V P T+ E +A + + +++ P A+
Sbjct: 486 ETPAEARSPLSEETSAEEAHAEVQSPLAEETTAEEASAEIQLLAAIEAPADETPAE--AQ 543
Query: 126 KQLPKRTIQEVLEEQSEDEDREAKRKKEEE----------EEETPKESLTEAEV--ATEK 173
L + T E E +E + AK EE EE T +E+ ++ ATE
Sbjct: 544 SPLSEETSAE--EAPAEVQSPSAKGVSIEEAPLELQPPSGEETTAEEASAAIQLLAATEA 601
Query: 174 EGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFT 233
E+ PP E P E P E+Q + P P
Sbjct: 602 SAEEAPAEVQPPPA-----EEAPAEVQPPPAEEAPAEVQPPPAEEAPAEVQPPPAEEAPA 656
Query: 234 PRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVP 288
+P +E E P +E AE P+ P + V P VP
Sbjct: 657 EVQPPPAEEAPAEVQPPPAEEAPAEVQSLPAEETPIEETLAAVHS---PPADDVP 708
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 51.6 bits (122), Expect = 3e-06
Identities = 71/281 (25%), Positives = 103/281 (36%), Gaps = 42/281 (14%)
Query: 11 PKKEGKAKK---PEKEAS-NSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGS 66
P K +A K PEK+ ++ E PP + V E P P + +
Sbjct: 10606 PVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPESPPPEV 10665
Query: 67 EGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARK 126
E E+ AL + PA V P PA P+ P +P+ + K+
Sbjct: 10666 FEEPEEVALE----EPPA---EVVEEPEPAAPPQVTVPPKKPVPEKKAPAVVAKK----P 10714
Query: 127 QLPKRTIQEVLEEQSEDEDREAKRKKEEEEE-----ETPKESLTEAEVATEKEGE--DGD 179
+LP + EV +E ++ K+ E E PKE + E +VA K+ E
Sbjct: 10715 ELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAK 10774
Query: 180 QPTTPPKPLKTSKA----------------ETPTESVSEPEVATKQE----LQEEEEQTK 219
P P KP+ K E P E E E+A ++E + EEEE
Sbjct: 10775 VPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEEEKPVPVAEEEEPEV 10834
Query: 220 PPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGP 260
PP P+ +K V K+ + P P E E P
Sbjct: 10835 PPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKP 10875
Score = 42.4 bits (98), Expect = 0.002
Identities = 65/278 (23%), Positives = 100/278 (35%), Gaps = 41/278 (14%)
Query: 11 PKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEE 70
P+K+ P K S E P + AL+E V E P P +V +
Sbjct: 10646 PEKKVPEAIPPKPESPPPEVFEEPEEVALEEPPAEVVEEPEPAAPP-----QVTVPPKKP 10700
Query: 71 EDEALSPAK-GQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK--------R 121
E +PA +KP L +V PE L ++ P+ +P+ +
Sbjct: 10701 VPEKKAPAVVAKKPELPPVKVPEVPKEVVPEKKVPLVVPKKPEAPPAKVPEVPKEVVPEK 10760
Query: 122 RTA---RKQLPKRTIQEV-----LEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEK 173
+ A + ++P + EV LEE+ E E E P+E E E+A E+
Sbjct: 10761 KVAVPKKPEVPPAKVPEVPKKPVLEEKPAVPVPERAESPPPEVYEEPEEIAPEEEIAPEE 10820
Query: 174 EGE----DGDQPTTPP-----KPLKT---------SKAETPTESVSEPEVATKQELQEEE 215
E + ++P PP +P K K E P EPE ++ +
Sbjct: 10821 EKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPKEPEPEKVIEKPKLKPR 10880
Query: 216 EQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPGK 253
PP + + K KK+V E+P P K
Sbjct: 10881 PPPPPPAPPKEDVKEKIFQLKAIPKKKV-PEKPQVPEK 10917
Score = 41.2 bits (95), Expect = 0.004
Identities = 55/243 (22%), Positives = 90/243 (37%), Gaps = 31/243 (12%)
Query: 29 RETEPPPKAALKEWNGVVSESDSPV-KRPGRKAARVLGSEGEEEDEALSPAKGQKPAL-- 85
++ E PP + VV E V K+P A+V + P +KPA+
Sbjct: 10740 KKPEAPPAKVPEVPKEVVPEKKVAVPKKPEVPPAKV-------PEVPKKPVLEEKPAVPV 10792
Query: 86 -DCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDE 144
+ ++ PP PE A + +P + P +P ++P + E ++ ++
Sbjct: 10793 PERAESPPPEVYEEPEEIAPEEEIAPEEEKP--VPVAEEEEPEVPPPAVPEEPKKIIPEK 10850
Query: 145 DREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPE 204
+K E + P E E EK P PP P K E + + P+
Sbjct: 10851 KVPVIKKPEAPPPKEP-----EPEKVIEKPKLKPRPPPPPPAPPKEDVKEKIFQLKAIPK 10905
Query: 205 VATKQELQEEEEQTKPPRRAP---KTLSSFFTPRKPAVKKEV----------KEEEPGAP 251
++ Q E+ P + P K + RKP K+EV +EEEP
Sbjct: 10906 KKVPEKPQVPEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVE 10965
Query: 252 GKE 254
K+
Sbjct: 10966 PKK 10968
Score = 39.7 bits (91), Expect = 0.013
Identities = 66/285 (23%), Positives = 104/285 (36%), Gaps = 69/285 (24%)
Query: 11 PKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPV-KRPGRKAARVLGSEGE 69
P++E ++ + E E PP A +E ++ E PV K+P + E E
Sbjct: 10812 PEEEIAPEEEKPVPVAEEEEPEVPPPAVPEEPKKIIPEKKVPVIKKPEAPPPK----EPE 10867
Query: 70 EEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARK-QL 128
E P +P PP P P+ D IPK++ K Q+
Sbjct: 10868 PEKVIEKPKLKPRP--------PPPPPAPPKE-----DVKEKIFQLKAIPKKKVPEKPQV 10914
Query: 129 PKRT-------------IQEVLEEQSEDEDREA-------KRKKEEEEEETPKESLTEAE 168
P++ ++++L E+ + E KR +EEE + PK+
Sbjct: 10915 PEKVELTPLKVPGGEKKVRKLLPERKPEPKEEVVLKSVLRKRPEEEEPKVEPKK------ 10968
Query: 169 VATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTL 228
EK + PPKP + E PT + E ++ ++ E + P PK
Sbjct: 10969 --LEKVKKPAVPEPPPPKP--VEEVEVPTVTKRERKIPEPTKVPEIKPAIPLPAPEPK-- 11022
Query: 229 SSFFTPRKPAVKKEVK----EEEP---GAP------GKEGAAEGP 260
P+ A K +K E EP AP GK+ A+ P
Sbjct: 11023 -----PKPEAEVKTIKPPPVEPEPTPIAAPVTVPVVGKKAEAKAP 11062
Score = 39.3 bits (90), Expect = 0.017
Identities = 65/290 (22%), Positives = 105/290 (36%), Gaps = 34/290 (11%)
Query: 16 KAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEAL 75
K K P K S + PP K K VV + P K P V+ E++
Sbjct: 10435 KPKAPPK-GPEISEKIIPPKKPPTK----VVPRKEPPAKVPEVPKKIVV------EEKVR 10483
Query: 76 SPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQ- 134
P + + P +V PP+ PE + ++ P +P+ ++ +P++ +
Sbjct: 10484 VPEEPRVPPTKVPEVLPPKEVV-PEKKVPVPPAKKPEAPPPKVPE--APKEVVPEKKVPV 10540
Query: 135 ------EVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEV--ATEKEGEDGDQPTTPPK 186
EV + + + A +K+ E PK EV A ++ + P PPK
Sbjct: 10541 PPPKKPEVPPTKVPEVPKAAVPEKKVPEAIPPKPESPPPEVPEAPKEVVPEKKVPAAPPK 10600
Query: 187 PLKTSKA---ETPTESVSEPEVATKQELQEEEEQTKPPR-----RAPKTLSSFFTPRKPA 238
+ + E P E V E +V + E TK P K + P+ +
Sbjct: 10601 KPEVTPVKVPEAPKEVVPEKKVPVPPPKKPEVPPTKVPEVPKVAVPEKKVPEAIPPKPES 10660
Query: 239 VKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVP 288
EV EE +E AE +P P + P + P +K P
Sbjct: 10661 PPPEVFEEPEEVALEEPPAEVVEEPEPAAPPQVTVPPKKPV---PEKKAP 10707
Score = 38.5 bits (88), Expect = 0.029
Identities = 68/283 (24%), Positives = 97/283 (34%), Gaps = 25/283 (8%)
Query: 13 KEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEED 72
+E + ++ E+ + TEP +K V E P K P A+VL EE
Sbjct: 9769 EEYEEREYERYEEHEEYITEPEKPIPVKP----VPEEPVPTK-PKAPPAKVLKKAVPEEK 9823
Query: 73 EALSPAKGQKPALDCSQVSPPRPATSP----ENNASLSDTSPMDSSPSGIPKRRTARKQL 128
+ K KP PP+ P E +S T + P + K
Sbjct: 9824 VPVPIPKKLKPP-------PPKVPEEPKKVFEEKIRISITK-REKEQVTEPAAKVPMK-- 9873
Query: 129 PKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEG---EDGDQPTTPP 185
PKR + E E R E +E P+E E EV T E E+ ++
Sbjct: 9874 PKRVVAEEKVPVPRKEVAPPVRVPEVPKELEPEEVAFEEEVVTHVEEYLVEEEEEYIHEE 9933
Query: 186 KPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKE 245
+ T + P V PEV K +E++ P ++ P+KP K V
Sbjct: 9934 EEFITEEEVVPVIPVKVPEVPRKPVPEEKKPVPVPKKKEAPPAKVPEVPKKPEEKVPVLI 9993
Query: 246 EEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVP 288
+ P E P P P + PV P KVP
Sbjct: 9994 PKKEKPPPAKVPEVPKKPV---PEEKVPVPVPKKVEAPPAKVP 10033
Score = 38.1 bits (87), Expect = 0.038
Identities = 56/232 (24%), Positives = 88/232 (37%), Gaps = 25/232 (10%)
Query: 29 RETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGE--EEDEALSPAKGQKPALD 86
RE P P A +E + E P + + VL E E E+E + P + + P +
Sbjct: 10092 REPVPVPVALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEE 10151
Query: 87 CSQVSPPRPATSPENNAS------LSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQ 140
+ PP PE L + P P+ +P+ + +K K+ + EE
Sbjct: 10152 --EEVPPEEEYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIK--KKVTEKKVVIPKKEEA 10207
Query: 141 SEDEDREAKRKKEEEEEETPKES-LTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTES 199
+ E +K EE+ PKE + EV E E E + P +P + E
Sbjct: 10208 PPAKVPEVPKKVEEKRIILPKEEEVLPVEVTEEPEEEPISEEEIPEEPPSIEEVE----E 10263
Query: 200 VSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAP 251
V+ P V + E T P++ P K V K++ EE+ P
Sbjct: 10264 VAPPRVPEVIKKAVPEAPTPVPKKVEAP------PAK--VSKKIPEEKVPVP 10307
Score = 37.7 bits (86), Expect = 0.050
Identities = 67/318 (21%), Positives = 113/318 (35%), Gaps = 44/318 (13%)
Query: 20 PEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSPAK 79
PE+ S E PP+ + V E+ +PV + + + EE + K
Sbjct: 10252 PEEPPSIEEVEEVAPPRVP-EVIKKAVPEAPTPVPKKVEAPPAKVSKKIPEEKVPVPVQK 10310
Query: 80 GQKPALDCSQVS----------PPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLP 129
+ P +V P + A P ++ + + + + ++
Sbjct: 10311 KEAPPAKVPEVPKKVPEKKVLVPKKEAVPPAKGRTVLEEKVSVAFRQEVVVKERLELEVV 10370
Query: 130 KRTIQEVLEEQSEDEDRE-------------AKRKKEEEEEETPKESLTEA-EVATEKEG 175
+ ++E+ EE+ E E K ++ EEE E + EV +E
Sbjct: 10371 EAEVEEIPEEEEFHEVEEYFEEGEFHEVEEFIKLEQHRVEEEHRVEKVHRVIEVFEAEEV 10430
Query: 176 EDGDQPTTPPKPLKTSKA-----ETPTESVSE-------PEVATKQELQEEEEQTKPPRR 223
E ++P PPK + S+ + PT+ V PEV K ++E+ + PR
Sbjct: 10431 EVFEKPKAPPKGPEISEKIIPPKKPPTKVVPRKEPPAKVPEVPKKIVVEEKVRVPEEPRV 10490
Query: 224 APKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYN---PAKNNYHPVEDAC 280
P + P++ +K+V P P K+ A P P P K P
Sbjct: 10491 PPTKVPEVLPPKEVVPEKKV----PVPPAKKPEAPPPKVPEAPKEVVPEKKVPVPPPKKP 10546
Query: 281 WKPGQKVPYLAVARTFEK 298
P KVP + A EK
Sbjct: 10547 EVPPTKVPEVPKAAVPEK 10564
Score = 36.6 bits (83), Expect = 0.11
Identities = 36/163 (22%), Positives = 64/163 (39%), Gaps = 24/163 (14%)
Query: 89 QVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARK-QLPKRTIQEVLEEQSEDEDRE 147
+V PP P + P + P +PK+ A ++P+ + V EE+ +
Sbjct: 9308 KVEPPAPKVPEVPKKPV----PEEKKPVPVPKKEPAAPPKVPEVPKKPVPEEKIPVPVAK 9363
Query: 148 AKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVAT 207
K + E K +TE ++ + E+ P P P K + P E
Sbjct: 9364 KKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPEIP----KKKVPEE--------- 9410
Query: 208 KQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGA 250
++ + +EE+ PP + P P+KP +++V P A
Sbjct: 9411 RKPVPRKEEEVPPPPKVPA------LPKKPVPEEKVAVPVPVA 9447
Score = 36.2 bits (82), Expect = 0.14
Identities = 82/333 (24%), Positives = 122/333 (36%), Gaps = 72/333 (21%)
Query: 18 KKPEKEASNSSRETEPPPKAALKEW-NGVVSESDSPVKRPGRKAARVLGSEGEEEDEALS 76
KKPE++ + E PP A + E V E PV P +V + +
Sbjct: 9983 KKPEEKVPVLIPKKEKPPPAKVPEVPKKPVPEEKVPVPVP----KKVEAPPAKVPEVPKK 10038
Query: 77 PAKGQKPALDCSQVSPPRPATSPENNASL--SDTSP------MDSSPSGIPKRRTA---- 124
P +K + + PA PE L + P +++ P +PK+R
Sbjct: 10039 PVPEKKVPVPAPKKVEAPPAKVPEVPKKLIPEEKKPTPVPKKVEAPPPKVPKKREPVPVP 10098
Query: 125 ------------RKQLPKRTI----QEVLEEQSE--DEDREAKRKKEE---EEEETPKES 163
+ +P+ + +EVL E+ E E+ E ++EE EEEE P E
Sbjct: 10099 VALPQEEEVLFEEEIVPEEEVLPEEEEVLPEEEEVLPEEEEVLPEEEEIPPEEEEVPPEE 10158
Query: 164 ---LTEAEVATEKEGEDGDQPTTP-PKPLKTSKAETPTESV-----------SEPEVATK 208
E E E+E +P P P P+ K + + V PEV K
Sbjct: 10159 EYVPEEEEFVPEEEVLPEVKPKVPVPAPVPEIKKKVTEKKVVIPKKEEAPPAKVPEVPKK 10218
Query: 209 QE-----LQEEE-----EQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEPGAPG---KEG 255
E L +EE E T+ P P +S P +P +EV+E P K+
Sbjct: 10219 VEEKRIILPKEEEVLPVEVTEEPEEEP--ISEEEIPEEPPSIEEVEEVAPPRVPEVIKKA 10276
Query: 256 AAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVP 288
E P P K P + + P +KVP
Sbjct: 10277 VPEAPTPV----PKKVEAPPAKVSKKIPEEKVP 10305
Score = 35.4 bits (80), Expect = 0.25
Identities = 38/125 (30%), Positives = 62/125 (49%), Gaps = 18/125 (14%)
Query: 134 QEVLEEQSED--EDREAKRKKE--EEEEETPKESLTEAEVA-TEKEGEDGDQPTTPPKPL 188
+EV EE ED E +E ++E +E EE +E+ E EV +KE + P +
Sbjct: 9110 KEVHEEWEEDFEEGQEYYEREEGYDEGEEEWEEAYQEREVIQVQKEVYEESHERKVPAKV 9169
Query: 189 KTSKAETPTESVSEPEVA----TKQELQEEEEQ-TKPPRRAPKTLSSFFTPRKPA---VK 240
KA P + + +P + T + ++EE+ Q TK P + K + P+KP+ V+
Sbjct: 9170 PEKKAPPPPKVIKKPVIEKIEKTSRRMEEEKVQVTKVPEVSKKIV-----PQKPSRTPVQ 9224
Query: 241 KEVKE 245
+EV E
Sbjct: 9225 EEVIE 9229
Score = 35.4 bits (80), Expect = 0.25
Identities = 65/273 (23%), Positives = 104/273 (38%), Gaps = 45/273 (16%)
Query: 11 PKKEGKAKKP---EKEASNSSRETEPPPKAALKEWNGVVSES-----------------D 50
PK KKP EK +++ E PP + GVV+E +
Sbjct: 9342 PKVPEVPKKPVPEEKIPVPVAKKKEAPPAKVPEVQKGVVTEEKITIVTQREESPPPAVPE 9401
Query: 51 SPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPAT--SPENNASLSDT 108
P K+ + V E E PA +KP + +V+ P P +P A +S
Sbjct: 9402 IPKKKVPEERKPVPRKEEEVPPPPKVPALPKKPVPE-EKVAVPVPVAKKAPPPRAEVSKK 9460
Query: 109 SPMDSSPSGIPKRRTARKQL----PKR---TIQEVLEEQS-----EDEDREAKRKKEEEE 156
+ ++ KR A ++L P+R T EV E+ E+E +EEE
Sbjct: 9461 TVVEE------KRFVAEEKLSFAVPQRVEVTRHEVSAEEEWSYSEEEEGVSISVYREEER 9514
Query: 157 EETPKESLTEAEVATEKEGEDGDQPT-TPPKPLKTSKAETPTESVSEPEVATKQELQEEE 215
EE + +TE EV E E ++ K ++ AE E ++ K ++ +
Sbjct: 9515 EEEEEAEVTEYEVMEEPEEYVVEEKLHIISKRVEAEPAEVTER--QEKKIVLKPKIPAKI 9572
Query: 216 EQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEP 248
E+ PP + P+ +K KE+ P
Sbjct: 9573 EE-PPPAKVPEAPKKIVPEKKVPAPVPKKEKVP 9604
Score = 35.0 bits (79), Expect = 0.32
Identities = 33/142 (23%), Positives = 58/142 (40%), Gaps = 16/142 (11%)
Query: 92 PPRPATSPENNASLSDTSPMDSSPSGI-PKRRTARKQLPKRTI-----QEVLEEQSEDED 145
PP A D + + P + P+ +K P T+ E+++ S+ E+
Sbjct: 8977 PPPKRIEVTKKAVKKDAKKVVAKPKEMTPREEIVKKPPPPTTLIPAKAPEIIDVSSKAEE 9036
Query: 146 REAKRKKEEEEEETPKESLTEAEVATEKEG--------EDGDQPTTPP--KPLKTSKAET 195
+ ++E + KE++ E + A KE E D+ P +P + E
Sbjct: 9037 VKIMTITRKKEVQKEKEAVYEKKQAVHKEKRVFIESFEEPYDELEVEPYTEPFEQPYYEE 9096
Query: 196 PTESVSEPEVATKQELQEEEEQ 217
P E E +V K+E+ EE E+
Sbjct: 9097 PDEDYEEIKVEAKKEVHEEWEE 9118
Score = 34.7 bits (78), Expect = 0.42
Identities = 53/232 (22%), Positives = 98/232 (42%), Gaps = 30/232 (12%)
Query: 18 KKPEKEASNSSRET-EPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALS 76
++ E+EA + E E P + ++E ++S KR + A V +E +E+ L
Sbjct: 9514 REEEEEAEVTEYEVMEEPEEYVVEEKLHIIS------KRVEAEPAEV--TERQEKKIVLK 9565
Query: 77 PAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEV 136
P + PA ++ P PA PE + P P+ +PK+ +++P + E
Sbjct: 9566 P---KIPA----KIEEPPPAKVPEAPKKIV---PEKKVPAPVPKK----EKVPPPKVPE- 9610
Query: 137 LEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETP 196
E + +++ K + EE P + +TE + +E + T P K E P
Sbjct: 9611 -EPKKPVPEKKVPPKVIKMEEPLPAK-VTERHMQITQEEKVLVAVTKKEAPPKARVPEEP 9668
Query: 197 TESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEEP 248
+V E +V + +EEE PP + + K +++ +E +P
Sbjct: 9669 KRAVPEEKVLKLKPKREEE----PPAKVTEFRKRVVKEEKVSIEAPKREPQP 9716
Score = 34.7 bits (78), Expect = 0.42
Identities = 66/290 (22%), Positives = 109/290 (37%), Gaps = 24/290 (8%)
Query: 13 KEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEED 72
+E K PEK+ + E P A + E + +++ + + +K A EE
Sbjct: 9610 EEPKKPVPEKKVPPKVIKMEEPLPAKVTERHMQITQEEKVLVAVTKKEAPPKARVPEEPK 9669
Query: 73 EA--------LSPAKGQKPALDCSQVSPPRPATSPENNASLS----DTSPMDSSPSGIPK 120
A L P + ++P ++V+ R E S+ + P+ K
Sbjct: 9670 RAVPEEKVLKLKPKREEEPP---AKVTEFRKRVVKEEKVSIEAPKREPQPIKEVTIMEEK 9726
Query: 121 RR--TARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDG 178
R T ++ +E EE E + +E + + E EE E E E +E E+
Sbjct: 9727 ERAYTLEEEAVSVQREEEYEEYEEYDYKEFE-EYEPTEEYDQYEEYEEREYERYEEHEEY 9785
Query: 179 DQPTTPPKPLKTSKAE-TPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKP 237
P P+K E PT+ + P K+ + EE K P PK L P+ P
Sbjct: 9786 ITEPEKPIPVKPVPEEPVPTKPKAPPAKVLKKAVPEE----KVPVPIPKKLKP-PPPKVP 9840
Query: 238 AVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKV 287
K+V EE+ + E +P+ P K E+ P ++V
Sbjct: 9841 EEPKKVFEEKIRISITKREKEQVTEPAAKVPMKPKRVVAEEKVPVPRKEV 9890
Score = 32.0 bits (71), Expect = 2.7
Identities = 47/260 (18%), Positives = 101/260 (38%), Gaps = 31/260 (11%)
Query: 74 ALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPK-----RRTARKQL 128
A+ A+ ++P + + + R T+ + + ++ + + K + ++L
Sbjct: 432 AVDMARVREPVISAVEQTAQRTTTTAVHIQPAQEQVRKEAEKTAVTKVVVAADKAKEQEL 491
Query: 129 PKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPL 188
RT + + +Q + + +KE E+ PK ++ A+ A E+E ++ T K +
Sbjct: 492 KSRTKEVITTKQEQMHVTHEQIRKETEKTFVPKVVISAAK-AKEQETRISEEITKKQKQV 550
Query: 189 --KTSKAETPTESVSEPEVATKQELQ-------EEEEQTKPPR------RAPKTLSSFFT 233
+ + ET + S VAT + + +EE T+ + + K
Sbjct: 551 TQEAIRQETEITAASMVVVATAKSTKLETVPGAQEETTTQQDQMHLSYEKIMKETRKTVV 610
Query: 234 PRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQKVPYLAVA 293
P+ +VKE++ + G+E G + ++ K +K +A
Sbjct: 611 PKVIVATPKVKEQDLVSRGRE----------GITTKREQVQITQEKMRKEAEKTALSTIA 660
Query: 294 RTFEKIEEVSARLRMVETLS 313
K +E LR ET++
Sbjct: 661 VATAKAKEQETILRTRETMA 680
Score = 30.4 bits (67), Expect = 7.9
Identities = 48/223 (21%), Positives = 82/223 (36%), Gaps = 38/223 (17%)
Query: 46 VSESDSPVKRPGRKAA-------------RVLGSEGEEE-----DEALSPAKGQKPALDC 87
+S+ D + RP R+ R LG +EE D+ L+ + ++ L
Sbjct: 32056 LSQDDLEIVRPARRRTPSPDYDFYYRPRRRSLGDISDEELLLPIDDYLAMKRTEEERLRL 32115
Query: 88 SQ-----VSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSE 142
+ S P+ SP + +S SSP K RK T + ++
Sbjct: 32116 EEELELGFSASPPSRSPPH---FELSSLRYSSPQAHVKVEETRKDFRYSTYHIPTKAEAS 32172
Query: 143 DEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSE 202
E + + + PK+ + E+E E+ +P T + L K+E S E
Sbjct: 32173 TSYAELRERHAQAAYRQPKQ---RQRIMAEREDEELLRPVTTTQHLSEYKSELDFMSKEE 32229
Query: 203 P---------EVATKQELQEEEEQTKPPRRAPKTLSSFFTPRK 236
EV E++EE E +K +R + +S R+
Sbjct: 32230 KSRKKSRRQREVTEITEIEEEYEISKHAQRESSSSASRLLRRR 32272
>gi|21493022 A kinase (PRKA) anchor protein 12 isoform 1 [Homo
sapiens]
Length = 1782
Score = 51.6 bits (122), Expect = 3e-06
Identities = 71/317 (22%), Positives = 116/317 (36%), Gaps = 35/317 (11%)
Query: 18 KKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSP 77
KK E E + + + + P A G + +S K+ K L E + E P
Sbjct: 202 KKDEGEGAAGAGDHKDPSLGA-----GEAASKESEPKQSTEKPEETLKRE-QSHAEISPP 255
Query: 78 AKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVL 137
A+ + +C + + P +A S TSP+ S K+ + R +
Sbjct: 256 AESGQAVEECKEEGEEKQEKEPSKSAE-SPTSPVTSETGSTFKKFFTQGWAGWRK-KTSF 313
Query: 138 EEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEK--------EGEDGDQPTTPPKPLK 189
+ EDE +++KKE+E E+ E +AEVA+EK E + P +
Sbjct: 314 RKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAE 373
Query: 190 TSKAETPTES--------VSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKK 241
K E P+E E E+ +E+ + + S R K
Sbjct: 374 YEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKT 433
Query: 242 EVKEEEPGAPGKEGAAEGPLDPSGYNPAK----------NNYHPVEDACWKPGQKVPYLA 291
EV+E P +E E +P PAK + P + A P +KV
Sbjct: 434 EVEETAGSVPAEE-LVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKP 492
Query: 292 VARTFEKIEEVSARLRM 308
++E +S++ RM
Sbjct: 493 PEGVVSEVEMLSSQERM 509
Score = 36.6 bits (83), Expect = 0.11
Identities = 23/105 (21%), Positives = 49/105 (46%), Gaps = 2/105 (1%)
Query: 116 SGIPKRRTARKQLPKRTIQEVLEE--QSEDEDREAKRKKEEEEEETPKESLTEAEVATEK 173
+GI + T +L + IQ +++ ++E+ E + + + K +A TEK
Sbjct: 1537 NGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEK 1596
Query: 174 EGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQT 218
EGE+ P+ ++K E+ + +V + +++ E E+T
Sbjct: 1597 EGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKT 1641
Score = 35.0 bits (79), Expect = 0.32
Identities = 49/227 (21%), Positives = 82/227 (36%), Gaps = 36/227 (15%)
Query: 30 ETEPPPKAALKEWNGVVSE------SDSPVKRPGRKAARVLGSEGEEEDE---ALSPAKG 80
+++ P L E++ V E + ++P +KAA + E E A + A G
Sbjct: 840 DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADG 899
Query: 81 QKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQ 140
+ A + SP + S + + + + A ++ P T+ E L E
Sbjct: 900 TRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPP--TVTEPLPE- 956
Query: 141 SEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDG--------------------DQ 180
+REA+ E E E++T AE A E+G D
Sbjct: 957 ----NREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDS 1012
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKT 227
P T + + E + E E T++ LQ E+ K + P T
Sbjct: 1013 PDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 1059
Score = 30.4 bits (67), Expect = 7.9
Identities = 49/233 (21%), Positives = 78/233 (33%), Gaps = 44/233 (18%)
Query: 23 EASNSSRETEPPPKAALKEWNGVVSESD------------SPVKR----------PGRKA 60
E + P K K GVVSE + SP+K+ G+K
Sbjct: 474 EDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQ 533
Query: 61 ARVLGSEGEEEDE-----ALSPAKGQKPALDCSQVSPPRPA-----------TSPENNAS 104
G EE E A SP ++ + S SP P + A
Sbjct: 534 KGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAE 593
Query: 105 LSDTSPMDSSPSGIPKRRTARKQL-PKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKES 163
TS + G+ + +K + PK+ ++ E EDE + K E T E
Sbjct: 594 EGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEM 653
Query: 164 LTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEE 216
E + + E+ +P P + + TS + V + ++ +EE
Sbjct: 654 QEEMKGSVEE-----PKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEE 701
>gi|21493024 A kinase (PRKA) anchor protein 12 isoform 2 [Homo
sapiens]
Length = 1684
Score = 51.6 bits (122), Expect = 3e-06
Identities = 71/317 (22%), Positives = 116/317 (36%), Gaps = 35/317 (11%)
Query: 18 KKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSP 77
KK E E + + + + P A G + +S K+ K L E + E P
Sbjct: 104 KKDEGEGAAGAGDHKDPSLGA-----GEAASKESEPKQSTEKPEETLKRE-QSHAEISPP 157
Query: 78 AKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVL 137
A+ + +C + + P +A S TSP+ S K+ + R +
Sbjct: 158 AESGQAVEECKEEGEEKQEKEPSKSAE-SPTSPVTSETGSTFKKFFTQGWAGWRK-KTSF 215
Query: 138 EEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEK--------EGEDGDQPTTPPKPLK 189
+ EDE +++KKE+E E+ E +AEVA+EK E + P +
Sbjct: 216 RKPKEDEVEASEKKKEQEPEKVDTEEDGKAEVASEKLTASEQAHPQEPAESAHEPRLSAE 275
Query: 190 TSKAETPTES--------VSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKK 241
K E P+E E E+ +E+ + + S R K
Sbjct: 276 YEKVELPSEEQVSGSQGPSEEKPAPLATEVFDEKIEVHQEEVVAEVHVSTVEERTEEQKT 335
Query: 242 EVKEEEPGAPGKEGAAEGPLDPSGYNPAK----------NNYHPVEDACWKPGQKVPYLA 291
EV+E P +E E +P PAK + P + A P +KV
Sbjct: 336 EVEETAGSVPAEE-LVEMDAEPQEAEPAKELVKLKETCVSGEDPTQGADLSPDEKVLSKP 394
Query: 292 VARTFEKIEEVSARLRM 308
++E +S++ RM
Sbjct: 395 PEGVVSEVEMLSSQERM 411
Score = 36.6 bits (83), Expect = 0.11
Identities = 23/105 (21%), Positives = 49/105 (46%), Gaps = 2/105 (1%)
Query: 116 SGIPKRRTARKQLPKRTIQEVLEE--QSEDEDREAKRKKEEEEEETPKESLTEAEVATEK 173
+GI + T +L + IQ +++ ++E+ E + + + K +A TEK
Sbjct: 1439 NGILELETKSSKLVQNIIQTAVDQFVRTEETATEMLTSELQTQAHVIKADSQDAGQETEK 1498
Query: 174 EGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQT 218
EGE+ P+ ++K E+ + +V + +++ E E+T
Sbjct: 1499 EGEEPQASAQDETPITSAKEESESTAVGQAHSDISKDMSEASEKT 1543
Score = 35.0 bits (79), Expect = 0.32
Identities = 49/227 (21%), Positives = 82/227 (36%), Gaps = 36/227 (15%)
Query: 30 ETEPPPKAALKEWNGVVSE------SDSPVKRPGRKAARVLGSEGEEEDE---ALSPAKG 80
+++ P L E++ V E + ++P +KAA + E E A + A G
Sbjct: 742 DSDVPAVVPLSEYDAVEREKMEAQQAQKSAEQPEQKAATEVSKELSESQVHMMAAAVADG 801
Query: 81 QKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQ 140
+ A + SP + S + + + + A ++ P T+ E L E
Sbjct: 802 TRAATIIEERSPSWISASVTEPLEQVEAEAALLTEEVLEREVIAEEEPP--TVTEPLPE- 858
Query: 141 SEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDG--------------------DQ 180
+REA+ E E E++T AE A E+G D
Sbjct: 859 ----NREARGDTVVSEAELTPEAVTAAETAGPLGAEEGTEASAAEETTEMVSAVSQLTDS 914
Query: 181 PTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKT 227
P T + + E + E E T++ LQ E+ K + P T
Sbjct: 915 PDTTEEATPVQEVEGGVPDIEEQERRTQEVLQAVAEKVKEESQLPGT 961
Score = 30.4 bits (67), Expect = 7.9
Identities = 49/233 (21%), Positives = 78/233 (33%), Gaps = 44/233 (18%)
Query: 23 EASNSSRETEPPPKAALKEWNGVVSESD------------SPVKR----------PGRKA 60
E + P K K GVVSE + SP+K+ G+K
Sbjct: 376 EDPTQGADLSPDEKVLSKPPEGVVSEVEMLSSQERMKVQGSPLKKLFTSTGLKKLSGKKQ 435
Query: 61 ARVLGSEGEEEDE-----ALSPAKGQKPALDCSQVSPPRPA-----------TSPENNAS 104
G EE E A SP ++ + S SP P + A
Sbjct: 436 KGKRGGGDEESGEHTQVPADSPDSQEEQKGESSASSPEEPEEITCLEKGLAEVQQDGEAE 495
Query: 105 LSDTSPMDSSPSGIPKRRTARKQL-PKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKES 163
TS + G+ + +K + PK+ ++ E EDE + K E T E
Sbjct: 496 EGATSDGEKKREGVTPWASFKKMVTPKKRVRRPSESDKEDELDKVKSATLSSTESTASEM 555
Query: 164 LTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEE 216
E + + E+ +P P + + TS + V + ++ +EE
Sbjct: 556 QEEMKGSVEE-----PKPEEPKRKVDTSVSWEALICVGSSKKRARRGSSSDEE 603
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 51.6 bits (122), Expect = 3e-06
Identities = 51/215 (23%), Positives = 94/215 (43%), Gaps = 24/215 (11%)
Query: 71 EDEALSPAKGQKPALD--CSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQL 128
E SP P+ + +V+P S A + + + D S +G KR T +++
Sbjct: 2529 ESSGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKKRFTPEEEM 2588
Query: 129 PKRTIQEVLEEQSEDEDREAKR-KKEEEEEETPKESLTEAEVATE----KEGEDGDQPTT 183
K + + ++ E E ++ + KKE ++EE+ S +A+ + + K G+ +
Sbjct: 2589 FKMVTKIKMFDELEQEAKQKRDYKKEPKQEESSSSSDPDADCSVDVDEPKHTGSGEDESG 2648
Query: 184 PPKPLKTSKAETPTESVSEPEVATKQE------LQEEEEQTKPPRRAPKTLSSFFTPR-- 235
P + + + + S SEPE+A ++ L E + +PP P ++ S +P
Sbjct: 2649 VPVLVTSESRKVSSSSESEPELAQLKKGADSGLLPEPVIRVQPPSPLPSSMDSNSSPEEV 2708
Query: 236 --KPAVKK-------EVKEEEPGAPGKEGAAEGPL 261
+P V K E +EEPG +E +E L
Sbjct: 2709 QFQPVVSKQYTFKMNEDTQEEPGKSEEEKDSESHL 2743
Score = 38.9 bits (89), Expect = 0.022
Identities = 71/329 (21%), Positives = 121/329 (36%), Gaps = 42/329 (12%)
Query: 12 KKEGKAKKPEKEASNSSRETEP------PPKAALKEWNGVVSESDSPVKRPGRKAARVLG 65
+KEGK P+ E ++ ++ +P P + LKE + + ++ KA G
Sbjct: 1676 EKEGKDIPPD-ETQSTQKQHKPSLGIKKPVRRKLKEKQ---KQKEEGLQASAEKAELKKG 1731
Query: 66 SEGEE--EDEALSP-----AKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGI 118
S E ED L+P K P ++ P + + A S +
Sbjct: 1732 SSEESLGEDPGLAPEPLPTVKATSPLIE----ETPIGSIKDKVKALQKRVEDEQKGRSKL 1787
Query: 119 PKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDG 178
P R ++ +PK+T S E + +T + S + TE+
Sbjct: 1788 PIRVKGKEDVPKKTTHRPHPAASPSLKSE-RHAPGSPSPKTERHSTLSSSAKTERHPPVS 1846
Query: 179 DQPTT----PPKPLKTSKAETPTESVSEPEV------ATKQELQEEEEQTKPPRRAPKTL 228
T P P ++ +P S S+ E +TK E TK R P +
Sbjct: 1847 PSSKTEKHSPVSPSAKTERHSPASSSSKTEKHSPVSPSTKTERHSPVSSTKTERHPPVSP 1906
Query: 229 SSFFTPRKPAVKKEVKEEE--PGAPGKEGAAEGPLDPSGYNPAKNNYHPVEDACWKPGQK 286
S T ++P V + E+ P +PG+ P+ PSG + + H K +
Sbjct: 1907 SG-KTDKRPPVSPSGRTEKHPPVSPGRT-EKRLPVSPSG----RTDKHQPVSTAGKTEKH 1960
Query: 287 VPYLAVARTFEK--IEEVSARLRMVETLS 313
+P +T ++ + S R+ ET+S
Sbjct: 1961 LPVSPSGKTEKQPPVSPTSKTERIEETMS 1989
Score = 33.9 bits (76), Expect = 0.72
Identities = 49/251 (19%), Positives = 88/251 (35%), Gaps = 17/251 (6%)
Query: 2 QRSIMSFFHPKKEGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAA 61
QR+ S H K + ++ E A++ + P P+A++K G S+ ++ P +
Sbjct: 2353 QRTFGSSAH-KTQTDSEVQESTATSDETKALPLPEASVKTDTGTESKPQGVIRSP-QGLE 2410
Query: 62 RVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKR 121
L S E A++ D + SP S + SP+ SP
Sbjct: 2411 LALPSRDSEVLSAVADDSLAVSHKDSLEASPVLEDNSSHKTPDSLEPSPLKESPCRDSLE 2470
Query: 122 RTARKQLPKRTI--------QEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEK 173
+ + K I V + + E + + + + + ++ E E
Sbjct: 2471 SSPVEPKMKAGIFPSHFPLPAAVAKTELLTEVASVRSRLLRDPDGSAEDDSLEQTSLMES 2530
Query: 174 EGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFT 233
G+ P TP + + T VS P+ A E EE++ ++ FT
Sbjct: 2531 SGKSPLSPDTPSSEEVSYEVTPKTTDVSTPKPAVIHECAEEDDSENGEKKR-------FT 2583
Query: 234 PRKPAVKKEVK 244
P + K K
Sbjct: 2584 PEEEMFKMVTK 2594
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 51.6 bits (122), Expect = 3e-06
Identities = 51/230 (22%), Positives = 96/230 (41%), Gaps = 16/230 (6%)
Query: 11 PKKEGKAK-KPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGE 69
P+ + K++ P + S SS E + P+AA + +G S+S K P +A G
Sbjct: 1583 PEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSG--SDSSPEPKAPAPRALPRRSRSG- 1639
Query: 70 EEDEALSPAKGQKPALDCSQVSPPRPATSPENNASL--SDTSPMDSSPSGIPKRRTARKQ 127
S +KG+ P+ + S + P P++ + S +SP + S P RR + +
Sbjct: 1640 ------SSSKGRGPSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRS 1693
Query: 128 LPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKP 187
P+ T + L +S + + S++ E A + + + P+
Sbjct: 1694 SPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRT 1753
Query: 188 LKTS-KAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRK 236
TS + +P+ +P + + E+T+ RR ++ SS T R+
Sbjct: 1754 KTTSRRGRSPS---PKPRGLQRSRSRSRREKTRTTRRRDRSGSSQSTSRR 1800
Score = 46.2 bits (108), Expect = 1e-04
Identities = 58/266 (21%), Positives = 95/266 (35%), Gaps = 30/266 (11%)
Query: 14 EGKAKKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDE 73
+G + P++ A + + PPK S S +P ++ +K + E
Sbjct: 147 DGSSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKK-----KDRGRRSE 201
Query: 74 ALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTI 133
+ SP + +K + S+ R + + S T P S KR+ +R P
Sbjct: 202 SSSPRRERKKS---SKKKKHRSESESKKRKHRSPT-PKSKRKSKDKKRKRSRSTTPAPKS 257
Query: 134 QEVLEEQSEDEDREAKRKKEEEEEETPKESLT-----EAEVATEKEGEDGDQPTTPPKPL 188
+ S D + + K T A+ + GE GD P + P
Sbjct: 258 RRAHRSTSADSASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGE-GDAPFSEP--- 313
Query: 189 KTSKAETPTESVSEPEVATKQ------ELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKE 242
T T+ S PE ATKQ + +++++ R +P S P PA
Sbjct: 314 ----GTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPL 369
Query: 243 VKEEEPGAPGKEGAAEGPLDPSGYNP 268
+ E G+P + A PL NP
Sbjct: 370 LAERHGGSP--QPLATTPLSQEPVNP 393
Score = 44.3 bits (103), Expect = 5e-04
Identities = 57/254 (22%), Positives = 96/254 (37%), Gaps = 38/254 (14%)
Query: 48 ESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPA-LDCSQVSPPR-------PATSP 99
+ ++P +RP L E+++E L A G + +D S P R PA P
Sbjct: 108 KEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAKQPAPEP 167
Query: 100 ENNASLSDTSPMDSSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDRE--AKRKKEEEEE 157
SL S SP+ K++ +K +R+ E S +R+ +K+KK E
Sbjct: 168 PKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRS-----ESSSPRRERKKSSKKKKHRSES 222
Query: 158 ETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQ 217
E+ K ++++ +D K K S++ TP +T + +
Sbjct: 223 ESKKRKHRSPTPKSKRKSKD--------KKRKRSRSTTPAPKSRRAHRSTSADSASSSDT 274
Query: 218 TKPPRR--APKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGPLDPSGYNPAKNNYHP 275
++ R A KT ++ R P+ A G+ G + P G + P
Sbjct: 275 SRSRSRSAAAKTHTTALAGRSPS----------PASGRRGEGDAPFSEPGTTSTQRPSSP 324
Query: 276 VEDACWKPGQKVPY 289
E A +P PY
Sbjct: 325 -ETATKQPSS--PY 335
Score = 42.7 bits (99), Expect = 0.002
Identities = 52/256 (20%), Positives = 85/256 (33%), Gaps = 14/256 (5%)
Query: 12 KKEGKAKKPEKEAS---NSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEG 68
++ A PE + SR + L++ +G S PG K S G
Sbjct: 1417 ERSSSASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRG 1476
Query: 69 EEEDEALSPAKGQKPALDCSQVSPPRPATSPE-NNASLSDTSPMDSSPSGIPKRRTARKQ 127
E ++ K AL + R +SPE NN L+ S S + ++ AR
Sbjct: 1477 RSECDSSPEPK----ALPQTPRPRSRSPSSPELNNKCLTPQRERSGSESSVDQKTVARTP 1532
Query: 128 LPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKP 187
L +R+ +E + + + +E E ++ +S + + G P K
Sbjct: 1533 LGQRSRSGSSQEL---DVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKS 1589
Query: 188 LKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVKEEE 247
+ + + S S PEV K + PK + PR+ K
Sbjct: 1590 RLSPRR---SRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRG 1646
Query: 248 PGAPGKEGAAEGPLDP 263
P G P P
Sbjct: 1647 PSPEGSSSTESSPEHP 1662
Score = 35.8 bits (81), Expect = 0.19
Identities = 55/277 (19%), Positives = 95/277 (34%), Gaps = 23/277 (8%)
Query: 7 SFFHPKK---EGKAKKPE--------KEASNSSRETEPPPKAALKEWNGVVSESDSPV-- 53
S F P++ E K PE +E+S+S T K K+ G SES SP
Sbjct: 149 SSFDPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRE 208
Query: 54 -KRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMD 112
K+ +K SE ++ K ++ + D + +P++ + TS
Sbjct: 209 RKKSSKKKKHRSESESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADS 268
Query: 113 SSPSGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKE-EEEEETPKESLTEAEVAT 171
+S S + R+ T S R + E T + + E AT
Sbjct: 269 ASSSDTSRSRSRSAAAKTHTTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETAT 328
Query: 172 --------EKEGEDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRR 223
+K+ + ++ T P P + P P +A + + T P +
Sbjct: 329 KQPSSPYEDKDKDKKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQ 388
Query: 224 APKTLSSFFTPRKPAVKKEVKEEEPGAPGKEGAAEGP 260
P S +P + + E+ P + E + P
Sbjct: 389 EPVNPPSEASPTRDRSPPKSPEKLPQSSSSESSPPSP 425
Score = 35.4 bits (80), Expect = 0.25
Identities = 34/138 (24%), Positives = 47/138 (34%), Gaps = 18/138 (13%)
Query: 12 KKEGKAKKPEKEASNSSRETEPP-PKAALKEWNGVVSE-------SDSPVKRPGR----- 58
KKE A +P SS EPP P L E +G + S PV P
Sbjct: 342 KKEKSATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPTR 401
Query: 59 -----KAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLSDTSPMDS 113
K+ L E SP + S P+PA +P ++ +S + +
Sbjct: 402 DRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKN 461
Query: 114 SPSGIPKRRTARKQLPKR 131
G KR + P R
Sbjct: 462 RSHGRAKRDKSHSHTPSR 479
Score = 34.3 bits (77), Expect = 0.55
Identities = 42/245 (17%), Positives = 82/245 (33%), Gaps = 28/245 (11%)
Query: 47 SESDSPVKRPGRKAARVLGSEGEEEDEALSPAKGQKPALDCSQVSPPRPATSPENNASLS 106
S S SP +R GR +R G + + + R T S S
Sbjct: 635 SRSRSPARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRS 694
Query: 107 DTSPMDSSPS-GIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLT 165
T S S + +R + + P+R + + +++ R ++R+ K+S
Sbjct: 695 RTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRI 754
Query: 166 EAEVATE--------------KEGEDGDQPT------TPPKPLKTSKAETPTESVSEPEV 205
+ + + G P TPP+ ++ ++ +S + P
Sbjct: 755 SSRRSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRR 814
Query: 206 ATKQELQEEEEQTKPPRRAPKTLS-------SFFTPRKPAVKKEVKEEEPGAPGKEGAAE 258
+ ++++K P R + S S PR+ ++ E+ P + E
Sbjct: 815 SRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVTPQRRSCFE 874
Query: 259 GPLDP 263
DP
Sbjct: 875 SSPDP 879
Score = 33.5 bits (75), Expect = 0.94
Identities = 45/231 (19%), Positives = 76/231 (32%), Gaps = 9/231 (3%)
Query: 18 KKPEKEASNSSRETEPPPKAALKEWNGVVSESDSPVKRPGRKAARVLGSEGEEEDEALSP 77
K PEK +SS E+ PP K S +SP P + R + S ++ +
Sbjct: 407 KSPEKLPQSSSSESSPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTSKNRSHGR 466
Query: 78 AKGQKPALDCSQVSPPR---PATSPENNASLSDTSPMDSSPSGIPK-RRTARKQLPKRTI 133
AK K R PAT+ + + S S P+ RR+ Q R+
Sbjct: 467 AKRDKSHSHTPSRRMGRSRSPATAKRGRSRSRTPTKRGHSRSRSPQWRRSRSAQRWGRSR 526
Query: 134 QEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEGEDGDQPTTPPKPLKTSKA 193
+S R + + S + G + P S++
Sbjct: 527 SPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARRGRSRS 586
Query: 194 ETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPRKPAVKKEVK 244
TP S T++ +++ P R ++ S R+ + V+
Sbjct: 587 RTPARRRSRSRTPTRR-----RSRSRTPARRGRSRSRTPARRRSRTRSPVR 632
Score = 30.4 bits (67), Expect = 7.9
Identities = 38/182 (20%), Positives = 65/182 (35%), Gaps = 41/182 (22%)
Query: 74 ALSPAKGQKPALDCSQVSPPRPATSPENNASLSD-TSPMDS-----------------SP 115
AL PAK ++ + S S ++S +++S S +S DS SP
Sbjct: 2523 ALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSP 2582
Query: 116 SGIPKRRTARKQLPKRTIQEVLEEQSEDEDREAKRKKEEEEEETPKESLTEAEVATEKEG 175
+ PK E + E E AKRK+ + S + + ++
Sbjct: 2583 TPAPK--------------EAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSS 2628
Query: 176 EDGDQPTTPPKPLKTSKAETPTESVSEPEVATKQELQEEEEQTKPPRRAPKTLSSFFTPR 235
++ +S + +P+ + P Q L + KPP ++ S PR
Sbjct: 2629 SSSSSSSSSSSSSSSSSSSSPSPAKPGP-----QALPKPASPKKPPPGERRSRS----PR 2679
Query: 236 KP 237
KP
Sbjct: 2680 KP 2681
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,800,942
Number of Sequences: 37866
Number of extensions: 2093569
Number of successful extensions: 25172
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 343
Number of HSP's successfully gapped in prelim test: 1142
Number of HSP's that attempted gapping in prelim test: 13145
Number of HSP's gapped (non-prelim): 6909
length of query: 919
length of database: 18,247,518
effective HSP length: 111
effective length of query: 808
effective length of database: 14,044,392
effective search space: 11347868736
effective search space used: 11347868736
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.