Search of human proteins with 4557391

Search of human proteins with 4557391

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4557391 complement component 8, beta polypeptide
preproprotein [Homo sapiens]
         (591 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4557391 complement component 8, beta polypeptide preproprotei...  1246   0.0  
gi|4557389 complement component 8, alpha polypeptide precursor [...   340   2e-93
gi|189242612 complement component 6 precursor [Homo sapiens]          286   3e-77
gi|169636415 complement component 6 precursor [Homo sapiens]          286   3e-77
gi|45580688 complement component 7 precursor [Homo sapiens]           245   7e-65
gi|4502511 complement component 9 precursor [Homo sapiens]            222   7e-58
gi|118572606 hemicentin 1 [Homo sapiens]                               60   4e-09
gi|32261318 unc-5 homolog B [Homo sapiens]                             59   2e-08
gi|134031945 SCO-spondin [Homo sapiens]                                59   2e-08
gi|40317626 thrombospondin 1 precursor [Homo sapiens]                  58   2e-08
gi|209977117 unc-5 homolog D [Homo sapiens]                            57   4e-08
gi|40317628 thrombospondin 2 precursor [Homo sapiens]                  57   6e-08
gi|147904700 semaphorin 5A [Homo sapiens]                              56   8e-08
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]                     56   1e-07
gi|16933525 unc5C [Homo sapiens]                                       55   2e-07
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot...    55   2e-07
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]      53   9e-07
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo...    52   1e-06
gi|62243567 netrin receptor Unc5h1 [Homo sapiens]                      52   1e-06
gi|93102379 low density lipoprotein-related protein 1B precursor...    52   2e-06
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [...    51   3e-06
gi|4507157 sortilin-related receptor containing LDLR class A rep...    50   6e-06
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo...    50   6e-06
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot...    50   8e-06
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot...    50   8e-06
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot...    50   8e-06
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot...    49   1e-05
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot...    49   1e-05
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo...    49   1e-05
gi|126012562 low density lipoprotein-related protein 1 [Homo sap...    49   2e-05

>gi|4557391 complement component 8, beta polypeptide preproprotein
           [Homo sapiens]
          Length = 591

 Score = 1246 bits (3225), Expect = 0.0
 Identities = 591/591 (100%), Positives = 591/591 (100%)

Query: 1   MKNSRTWAWRAPVELFLLCAALGCLSLPGSRGERPHSFGSNAVNKSFAKSRQMRSVDVTL 60
           MKNSRTWAWRAPVELFLLCAALGCLSLPGSRGERPHSFGSNAVNKSFAKSRQMRSVDVTL
Sbjct: 1   MKNSRTWAWRAPVELFLLCAALGCLSLPGSRGERPHSFGSNAVNKSFAKSRQMRSVDVTL 60

Query: 61  MPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQV 120
           MPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQV
Sbjct: 61  MPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQV 120

Query: 121 RCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQHEMDQYWGIGSLASGIN 180
           RCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQHEMDQYWGIGSLASGIN
Sbjct: 121 RCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQHEMDQYWGIGSLASGIN 180

Query: 181 LFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDF 240
           LFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDF
Sbjct: 181 LFTNSFEGPVLDHRYYAGGCSPHYILNTRFRKPYNVESYTPQTQGKYEFILKEYESYSDF 240

Query: 241 ERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLE 300
           ERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLE
Sbjct: 241 ERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRFSHTKSVFLHARSDLE 300

Query: 301 VAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRDFGTHYITEAVLGGIYEYTLVM 360
           VAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRDFGTHYITEAVLGGIYEYTLVM
Sbjct: 301 VAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRDFGTHYITEAVLGGIYEYTLVM 360

Query: 361 NKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMV 420
           NKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMV
Sbjct: 361 NKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKCRGILNEIKDRNKRDTMV 420

Query: 421 EDLVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFA 480
           EDLVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFA
Sbjct: 421 EDLVVLVRGGASEHITTLAYQELPTADLMQEWGDAVQYNPAIIKVKVEPLYELVTATDFA 480

Query: 481 YSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRK 540
           YSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRK
Sbjct: 481 YSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRK 540

Query: 541 NTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           NTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS
Sbjct: 541 NTPIDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591


>gi|4557389 complement component 8, alpha polypeptide precursor
           [Homo sapiens]
          Length = 584

 Score =  340 bits (872), Expect = 2e-93
 Identities = 184/559 (32%), Positives = 286/559 (51%), Gaps = 42/559 (7%)

Query: 63  IDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQVRC 122
           + C+LS+WS WT C PCQ K+YR+  LLQP++F G  C+    +   C ++  C  Q +C
Sbjct: 37  VTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTCVRQAQC 96

Query: 123 -EGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQHEMDQYW---GIGSLASG 178
            + F C +TGRC+ R L+CNGD DC D SDE +C  + +    +  QY    G    A G
Sbjct: 97  GQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDV-RAIDEDCSQYEPIPGSQKAALG 155

Query: 179 INLFTNSFEGPVLDHRYYAGGCSPHYILNTR-------------------FRKPYNVESY 219
            N+ T      V D  YY G C   Y    R                   FRKPYN   Y
Sbjct: 156 YNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLKY 215

Query: 220 TPQTQGKYEFILKEYESYSDFERNVTEKMASKSGFSFGFKIPG---IFELGISSQSDRGK 276
             +         + Y++ +D    V +  +   G + G    G   +  +G+S   D   
Sbjct: 216 HFEALADTGISSEFYDNANDLLSKVKKDKSDSFGVTIGIGPAGSPLLVGVGVSHSQDTS- 274

Query: 277 HYIRRTKRFSHTKSVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDL 336
            ++    +++  K +F    + ++ AH+K++   +ML    LQ +  LP +Y+YG Y   
Sbjct: 275 -FLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNYGMYAKF 333

Query: 337 FRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAI-----EE 391
             D+GTHYIT   +GGIYEY LV++K  ME    T  ++  C       GG++     ++
Sbjct: 334 INDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTC------FGGSLGIQYEDK 387

Query: 392 VYVSLGVSVGKCRGILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQELPTADLMQE 451
           + V  G+S   C+       +R ++   VED++  VRGG+S     LA     +    + 
Sbjct: 388 INVGGGLSGDHCKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNR--STITYRS 445

Query: 452 WGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGN 511
           WG +++YNP +I  +++P++E++  T        RQN+++AL+++  E ++C C PC  N
Sbjct: 446 WGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGPCFNN 505

Query: 512 GVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNP 571
           GVP+L+G+ C C C +GS G ACE +  +    DG W+CWS+WS C    + R+R+C+NP
Sbjct: 506 GVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWSCWSSWSVCRAGIQERRRECDNP 565

Query: 572 PPQNGGSPCSGPASETLDC 590
            PQNGG+ C G   +T  C
Sbjct: 566 APQNGGASCPGRKVQTQAC 584


>gi|189242612 complement component 6 precursor [Homo sapiens]
          Length = 934

 Score =  286 bits (733), Expect = 3e-77
 Identities = 166/561 (29%), Positives = 280/561 (49%), Gaps = 24/561 (4%)

Query: 45  KSFAKSRQMRSVDVTLMPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSD 104
           +     ++ R  +    PI+C L  +  W+ CDPC +K+ +   +L+PSQF G+PC    
Sbjct: 62  EQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPL 121

Query: 105 KEVEDCVTNRPCG-SQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQ 163
              + C+ ++ C   +  C+      +GRC+ R+L CNG+NDCGD SDE +C R    C 
Sbjct: 122 VAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCT 181

Query: 164 HEMDQYWGIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTR--FRKPYNVESYTP 221
            + +    +  + +G +       G VLD+ +  G C       T   +R P N+E+   
Sbjct: 182 RKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGF 241

Query: 222 QTQGKYEFILKE-YESYSDFERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIR 280
           + Q   + +  + Y+  +    N  ++ +  S     F +P IF     S++       +
Sbjct: 242 EVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVP-IFYSSKRSENINHNSAFK 300

Query: 281 RTKRFSHTK-SVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRD 339
           +  + SH K S F+     ++V ++  K + L L   FL+ +  LPLEY+   Y  +F D
Sbjct: 301 QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD 360

Query: 340 FGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVS 399
           FGTHY T   LGG+Y+     + E ++    T      C + + K     + V  +    
Sbjct: 361 FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETK-----KRVLFAKKTK 415

Query: 400 VGKCRGILNEIKDRNKRDTM--VEDLVVLVRGGASEHITTLAYQELPTA---DLMQEWGD 454
           V + R   N++ ++++   +   E  + L+RGG SE+   LA+++  +        EW +
Sbjct: 416 V-EHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLE 474

Query: 455 AVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVP 514
           +V+ NPA+I  ++ P+ +LV   +   + T R N+++AL+E+  +   C CAPC  NG P
Sbjct: 475 SVKENPAVIDFELAPIVDLV--RNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRP 532

Query: 515 VLKGSRCDCICPVGSQGLACE---VSYRKNTPIDGKWNCWSNWSSCSGR-RKTRQRQCNN 570
            L G+ C C+C  G+ G  CE     Y+ N  +DG+W CWS+WS+C    +++R R+CNN
Sbjct: 533 TLSGTECLCVCQSGTYGENCEKQSPDYKSNA-VDGQWGCWSSWSTCDATYKRSRTRECNN 591

Query: 571 PPPQNGGSPCSGPASETLDCS 591
           P PQ GG  C G   +  DC+
Sbjct: 592 PAPQRGGKRCEGEKRQEEDCT 612


>gi|169636415 complement component 6 precursor [Homo sapiens]
          Length = 934

 Score =  286 bits (733), Expect = 3e-77
 Identities = 166/561 (29%), Positives = 280/561 (49%), Gaps = 24/561 (4%)

Query: 45  KSFAKSRQMRSVDVTLMPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSD 104
           +     ++ R  +    PI+C L  +  W+ CDPC +K+ +   +L+PSQF G+PC    
Sbjct: 62  EQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPL 121

Query: 105 KEVEDCVTNRPCG-SQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQ 163
              + C+ ++ C   +  C+      +GRC+ R+L CNG+NDCGD SDE +C R    C 
Sbjct: 122 VAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCT 181

Query: 164 HEMDQYWGIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTR--FRKPYNVESYTP 221
            + +    +  + +G +       G VLD+ +  G C       T   +R P N+E+   
Sbjct: 182 RKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGF 241

Query: 222 QTQGKYEFILKE-YESYSDFERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIR 280
           + Q   + +  + Y+  +    N  ++ +  S     F +P IF     S++       +
Sbjct: 242 EVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVP-IFYSSKRSENINHNSAFK 300

Query: 281 RTKRFSHTK-SVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRD 339
           +  + SH K S F+     ++V ++  K + L L   FL+ +  LPLEY+   Y  +F D
Sbjct: 301 QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD 360

Query: 340 FGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVS 399
           FGTHY T   LGG+Y+     + E ++    T      C + + K     + V  +    
Sbjct: 361 FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETK-----KRVLFAKKTK 415

Query: 400 VGKCRGILNEIKDRNKRDTM--VEDLVVLVRGGASEHITTLAYQELPTA---DLMQEWGD 454
           V + R   N++ ++++   +   E  + L+RGG SE+   LA+++  +        EW +
Sbjct: 416 V-EHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLE 474

Query: 455 AVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVP 514
           +V+ NPA+I  ++ P+ +LV   +   + T R N+++AL+E+  +   C CAPC  NG P
Sbjct: 475 SVKENPAVIDFELAPIVDLV--RNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRP 532

Query: 515 VLKGSRCDCICPVGSQGLACE---VSYRKNTPIDGKWNCWSNWSSCSGR-RKTRQRQCNN 570
            L G+ C C+C  G+ G  CE     Y+ N  +DG+W CWS+WS+C    +++R R+CNN
Sbjct: 533 TLSGTECLCVCQSGTYGENCEKQSPDYKSNA-VDGQWGCWSSWSTCDATYKRSRTRECNN 591

Query: 571 PPPQNGGSPCSGPASETLDCS 591
           P PQ GG  C G   +  DC+
Sbjct: 592 PAPQRGGKRCEGEKRQEEDCT 612


>gi|45580688 complement component 7 precursor [Homo sapiens]
          Length = 843

 Score =  245 bits (626), Expect = 7e-65
 Identities = 164/554 (29%), Positives = 256/554 (46%), Gaps = 38/554 (6%)

Query: 52  QMRSVDVTLMPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCV 111
           + +S      P++C+   ++ W+ C+ C K + R   +    Q+ G+PC  +  E + C 
Sbjct: 15  EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCE 74

Query: 112 TNRPCGSQVRC-EGFVCAQTGRCVNRRLLCNGDNDCG-DQSDEANCRRIYKKCQHEMDQY 169
             R C ++  C E F C  +G+C+++ L+CNGD+DC  D +DE  C    ++   ++D+ 
Sbjct: 75  PTRGCPTEEGCGERFRCF-SGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDIDKP 133

Query: 170 W-GIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTR--FRKPYNVESYTPQTQGK 226
              I    +G N  T  F   V++ + + G C   +  + +  +R   NV SYT Q +  
Sbjct: 134 PPNIELTGNGYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKIN 193

Query: 227 YEFILKEYES-YSDFERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIRRTKRF 285
            +F  + Y S +S  +   TE  +S    SF             S S   + Y   T   
Sbjct: 194 NDFNYEFYNSTWSYVKHTSTEHTSSSRKRSF-----------FRSSSSSSRSYTSHTNEI 242

Query: 286 SHTKSV-FLHARSDLEVAHY-KLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRDFGTH 343
              KS   L   + +EVA +    P  L L   F + +  LP  Y Y  YR L   +GTH
Sbjct: 243 HKGKSYQLLVVENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTH 302

Query: 344 YITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVSVGKC 403
           Y+    LGG Y     ++ E +++ D+       C  + +         +  +  S   C
Sbjct: 303 YLQSGSLGGEYRVLFYVDSEKLKQNDFNSVEEKKCKSSGW---------HFVVKFSSHGC 353

Query: 404 RGILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQEL--PTADLMQ--EWGDAVQYN 459
           + + N +K  +     V      +RGG +  I+ L+Y EL  P  +  +   W ++V   
Sbjct: 354 KELENALKAASGTQNNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNL 413

Query: 460 PAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGS 519
           P +IK K+ PLYELV     A  S  +  +K ALEE+  E   CHC PCQ  G+  ++G+
Sbjct: 414 PQVIKQKLTPLYELVKEVPCA--SVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGT 471

Query: 520 RCDCICPVGSQGLACEVSYRKNTP---IDGKWNCWSNWSSCSGRRKTRQRQCNNPPPQNG 576
            C C C   + G ACE           +DG W+CWS+WS C   +KTR R+CNNPPP  G
Sbjct: 472 HCLCHCKPYTFGAACEQGVLVGNQAGGVDGGWSCWSSWSPCVQGKKTRSRECNNPPPSGG 531

Query: 577 GSPCSGPASETLDC 590
           G  C G  +E+  C
Sbjct: 532 GRSCVGETTESTQC 545


>gi|4502511 complement component 9 precursor [Homo sapiens]
          Length = 559

 Score =  222 bits (566), Expect = 7e-58
 Identities = 144/512 (28%), Positives = 239/512 (46%), Gaps = 41/512 (8%)

Query: 63  IDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPC-GSQVR 121
           IDC +S WS W+ CDPC ++ +R   +    QF+G+ C  +  +   CV   PC  ++  
Sbjct: 41  IDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD 100

Query: 122 CEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKK-CQHEMDQYWGIGSLAS-GI 179
           C       TGRC+  RL CNGDNDCGD SDE +C    +  C+  + +   +   A  GI
Sbjct: 101 CGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELARTAGYGI 160

Query: 180 NLFTNSFEGPVLDHRYYAGGCSPHYILNTR--FRKPYNVESYTPQTQGKYEFILKEYESY 237
           N+          D+ +Y G C+     NT   +R+P+NV S   +T+G+  F  + YE  
Sbjct: 161 NILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETKGEKNFRTEHYEEQ 220

Query: 238 SDFERNVTEKMASKSGFSFGFKIPGI--------FELGISSQSDRGKHYIRRTKRFSHTK 289
            +  +++ ++  S    +   K             E   SS S  GK   R    FS++K
Sbjct: 221 IEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKGSFR----FSYSK 276

Query: 290 S---------------VFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYR 334
           +               +FLH + ++ +  + ++ R ++L   F+  +K LP  Y  GEY 
Sbjct: 277 NETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPTTYEKGEYF 336

Query: 335 DLFRDFGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYV 394
                +GTHY +   LGG+YE   V++K +M+R    L ++  C      +  A  E+ V
Sbjct: 337 AFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVSLAFSEISV 396

Query: 395 SLGVSVGKC--RGILNEIKDRNKRDTMVEDLVVLVRGGASEHITTLAYQELPTADL---- 448
               +   C  RG    +   +  + +++D+V L+RGG  ++   L  + L    +    
Sbjct: 397 GAEFNKDDCVKRGEGRAVNITS--ENLIDDVVSLIRGGTRKYAFELKEKLLRGTVIDVTD 454

Query: 449 MQEWGDAVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPC 508
              W  ++   P +I  K+ P+Y LV       +   +QN+++A+E++  E S   C  C
Sbjct: 455 FVNWASSINDAPVLISQKLSPIYNLV-PVKMKNAHLKKQNLERAIEDYINEFSVRKCHTC 513

Query: 509 QGNGVPVLKGSRCDCICPVGSQGLACEVSYRK 540
           Q  G  +L   +C C CP   +G+ACE+S +K
Sbjct: 514 QNGGTVILMDGKCLCACPFKFEGIACEISKQK 545


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 38/116 (32%), Positives = 48/116 (41%), Gaps = 27/116 (23%)

Query: 503  CHCAPC--QGNGVPVLKGSRCDCIC--------------PVGSQGLAC----EVSYRKNT 542
            C+  PC   GN  P      C   C              P  + G AC        R NT
Sbjct: 4749 CNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNT 4808

Query: 543  ---PIDGKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
               P+DG W  W +WS CS    G  KTR+R C++P P  GG PC G  ++   C+
Sbjct: 4809 DMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCN 4864



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 27/56 (48%), Positives = 34/56 (60%), Gaps = 4/56 (7%)

Query: 540  KNTPIDGKWNCWSNWSSCS---GR-RKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
            K  P+DG W+ WS W  C+   GR  +TR R CNNP  Q+GG PC G A E + C+
Sbjct: 4581 KPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCN 4636



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 31/85 (36%), Positives = 44/85 (51%), Gaps = 10/85 (11%)

Query: 511  NGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCS----GRRKTRQR 566
            N  P   GS CD     G++    +V   +N PI GKW  W++WS+CS    G  + R R
Sbjct: 4672 NPPPAFGGSYCD-----GAE-TQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQRTR 4725

Query: 567  QCNNPPPQNGGSPCSGPASETLDCS 591
             C++P PQ GG  C G   ++  C+
Sbjct: 4726 GCSDPVPQYGGRKCEGSDVQSDFCN 4750



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 23/89 (25%)

Query: 507  PCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGR----RK 562
            PC+GN V ++  +   C                   P+ G W+ W  W +CS       +
Sbjct: 4624 PCEGNAVEIIMCNIRPC-------------------PVHGAWSAWQPWGTCSESCGKGTQ 4664

Query: 563  TRQRQCNNPPPQNGGSPCSGPASETLDCS 591
            TR R CNNPPP  GGS C G  ++   C+
Sbjct: 4665 TRARLCNNPPPAFGGSYCDGAETQMQVCN 4693



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 22/52 (42%), Positives = 28/52 (53%), Gaps = 6/52 (11%)

Query: 544  IDGKWNCWSNWSSCS-----GRRKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
            + G ++ WS W +CS     G +K R R CN P P NGG PC G   E  +C
Sbjct: 4528 VHGGFSQWSAWRACSVTCGKGIQK-RSRLCNQPLPANGGKPCQGSDLEMRNC 4578



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 21/79 (26%), Positives = 30/79 (37%), Gaps = 5/79 (6%)

Query: 52   QMRSVDVTLMPIDCELSSWSSWTTCDPC----QKKRYRYAYLLQPSQFHGEPCNFSDKEV 107
            Q++  +  + P+D    SW SW+ C       +K R R      P +  G PC     +V
Sbjct: 4802 QIQRCNTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVK-GGRPCPGDTTQV 4860

Query: 108  EDCVTNRPCGSQVRCEGFV 126
              C      G   R  G V
Sbjct: 4861 TRCNVQACPGGPQRARGSV 4879


>gi|32261318 unc-5 homolog B [Homo sapiens]
          Length = 945

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 24/50 (48%), Positives = 31/50 (62%), Gaps = 1/50 (2%)

Query: 543 PIDGKWNCWSNWSSCSGR-RKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           P+DG W  WS WS+CS      R R+C  PPPQNGG  CSG   ++ +C+
Sbjct: 300 PVDGAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCT 349



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 21/52 (40%), Positives = 29/52 (55%), Gaps = 4/52 (7%)

Query: 544 IDGKWNCWSNWSSCSGRR----KTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           ++G W+ W+ WS CS R     + R R C NP P NGG+ C G A +   C+
Sbjct: 245 VNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACT 296


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 23/52 (44%), Positives = 30/52 (57%), Gaps = 4/52 (7%)

Query: 543  PIDGKWNCWSNWS----SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
            P+ G W  W  W     SC G  ++RQR C +PPP+NGG+PC G + E   C
Sbjct: 2553 PVAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPC 2604



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 34/110 (30%), Positives = 46/110 (41%), Gaps = 26/110 (23%)

Query: 503  CHCAPCQ---GNGVPVLKGSRCDCIC---------------PVGSQGLACEVSYRKNT-- 542
            C+C P Q    NG   ++   C C+                P G     C       T  
Sbjct: 3344 CYCPPGQVLSSNGAICVQPGHCSCLDLLTGQRHHPGARLARPDGCNHCTCLEGRLNCTDL 3403

Query: 543  --PIDGKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSGPASE 586
              P+ G W  WS W+ CS    G+ ++R R C  P PQ+GG+PC+G A E
Sbjct: 3404 PCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGE 3453



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 22/53 (41%), Positives = 32/53 (60%), Gaps = 4/53 (7%)

Query: 543  PIDGKWNCWSNWS----SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
            P+ G W+ WS WS    SC G +  R R C++PP +NGG+PC+G   +   C+
Sbjct: 4002 PVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCN 4054



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 31/98 (31%), Positives = 43/98 (43%), Gaps = 12/98 (12%)

Query: 500  VSSCHCA---PCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWS- 555
            +S C C      +  GV  L G+   C+C  G   L C+       P+   W+ WS+W+ 
Sbjct: 2672 LSECPCLVGEELKWPGVSFLLGNCSQCVCEKGE--LLCQPG---GCPLPCGWSAWSSWAP 2726

Query: 556  ---SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
               SC    + R R  +NPP   GG+PC G   E   C
Sbjct: 2727 CDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGC 2764



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 22/42 (52%), Positives = 29/42 (69%), Gaps = 5/42 (11%)

Query: 543  PIDGKWNCWSNWSSCSGRRK---TRQRQCNNPPPQNGGSPCS 581
            P+DG+W+ WS WS CS   +   TRQRQC++  PQNGG  C+
Sbjct: 1748 PVDGEWSTWSPWSVCSEPCRGTMTRQRQCHS--PQNGGRTCA 1787



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 31/96 (32%), Positives = 38/96 (39%), Gaps = 17/96 (17%)

Query: 502  SCHCAPCQGNGVPVLKGSRCDCICPVGSQGL-----ACEVSYRKNTPIDGKWNCWSNWSS 556
            +C C   Q  G P        C    G  G      AC  SY    P+DG W  W  WS 
Sbjct: 3434 ACACPTPQHGGAP--------CTGEAGEAGAQHQREACP-SYA-TCPVDGAWGPWGPWSP 3483

Query: 557  CSG--RRKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
            C     +  R R C+ PP   GG PC G  +++  C
Sbjct: 3484 CDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPC 3519



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 20/49 (40%), Positives = 25/49 (51%), Gaps = 4/49 (8%)

Query: 546  GKWNCWSNWS----SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
            G W  W  WS    SC G  ++R R C+ PPPQ  G  C GP ++   C
Sbjct: 3253 GGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVC 3301



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 21/53 (39%), Positives = 30/53 (56%), Gaps = 6/53 (11%)

Query: 543  PIDGKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
            P+   W  W+ WS+CS    G  +TR R C++  P  G + C GP S+T DC+
Sbjct: 2828 PVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAP--GDTTCPGPHSQTRDCN 2878



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 11/72 (15%)

Query: 520  RCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWS----SCSGRRKTRQRQCNNPPPQN 575
            RC C      +G+ CE +      +   W  WS+WS    SC G  + R R C    P +
Sbjct: 4235 RCSCT----PEGVICEDT---ECAVPEAWTLWSSWSDCPVSCGGGNQVRTRACRAAAPHH 4287

Query: 576  GGSPCSGPASET 587
               PC GP ++T
Sbjct: 4288 RSPPCLGPDTQT 4299



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 26/81 (32%), Positives = 35/81 (43%), Gaps = 15/81 (18%)

Query: 515  VLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWS----SCSGRRKTRQRQCNN 570
            V+ G   +C C  G   L C+     + P  G W+ W  W     SC G  + R R+C  
Sbjct: 3619 VVTGPCDNCTCVAGI--LQCQEV--PDCPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCAR 3674

Query: 571  PPPQNGGSPCSGPASETLDCS 591
            P       PC GPA ++  CS
Sbjct: 3675 P-------PCPGPARQSRTCS 3688



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 30/96 (31%), Positives = 38/96 (39%), Gaps = 17/96 (17%)

Query: 507  PCQGNGVPVLKGSRC------DCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCS-- 558
            PCQ +G     G+        +C C  G      E       P+   W+ W+ WS CS  
Sbjct: 2946 PCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSE-----RCPVACGWSPWTLWSLCSCS 3000

Query: 559  ---GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
               G R+ R R    PP   GG+ C GP  E   CS
Sbjct: 3001 CNVGIRR-RFRAGTAPPAAFGGAECQGPTMEAEFCS 3035



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 23/83 (27%), Positives = 31/83 (37%), Gaps = 7/83 (8%)

Query: 507  PCQGNGVPVLKGSR--CDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTR 564
            PC  +G     G R   DC   +   G         +  +D  W+ WS W+ C G   ++
Sbjct: 1869 PCLVDGARYWPGQRIKADCQLCICQDGRPRRCRLNPDCAVDCGWSSWSPWAKCLGPCGSQ 1928

Query: 565  Q-----RQCNNPPPQNGGSPCSG 582
                  R  NNP P   G  C G
Sbjct: 1929 SIQWSFRSSNNPRPSGRGRQCRG 1951



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 32/112 (28%), Positives = 45/112 (40%), Gaps = 20/112 (17%)

Query: 62   PIDCELSSWSSWTTCDPCQKKRYRYAYLL---QPSQFHGEPCNFSDKEVEDCVTNRPCGS 118
            P+ C  S+WSSW  CD       R  +      P+ + G PC    +E++ C T   CG+
Sbjct: 2713 PLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHT--VCGT 2770

Query: 119  QV----------RCEGFVCAQTG----RCVNRRLLCNGDNDC-GDQSDEANC 155
            +V           C     A  G    R  +R     GD+ C GD + E  C
Sbjct: 2771 EVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSRLCPSPGDSSCPGDATQEEPC 2822



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 14/30 (46%), Positives = 18/30 (60%)

Query: 126  VCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            +C + G CV    LC+  +DCGD SDE  C
Sbjct: 1382 LCQENGHCVPHGWLCDNQDDCGDGSDEEGC 1411



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 23/87 (26%), Positives = 34/87 (39%), Gaps = 12/87 (13%)

Query: 507  PCQGNGVPVLKGSRCDCICPVGSQGLACEVS---------YRKNTPIDGKWNCWSNWSSC 557
            PC  +  P L      C C +      C  +         Y    P +  W+ WS+W+ C
Sbjct: 4318 PCSRSCGPGLASRSGSCPCLMAKADPTCNSTFLHLDTQGCYSGPCPEECVWSSWSSWTRC 4377

Query: 558  SGRRKTRQRQCNNPPPQNG---GSPCS 581
            S R   +QR  +  P   G   G+PC+
Sbjct: 4378 SCRVLVQQRYRHQGPASRGARAGAPCT 4404



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 14/33 (42%), Positives = 20/33 (60%)

Query: 123  EGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            +G +    GRC+   LLC+G  DC D +DE +C
Sbjct: 1454 QGLLACADGRCLPPALLCDGHPDCLDAADEESC 1486



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 24/80 (30%), Positives = 33/80 (41%), Gaps = 10/80 (12%)

Query: 516  LKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGR-----RKTRQRQCNN 570
            L+ S  +C C  G    + +  +      DG +  WS W  CS        +TR RQC  
Sbjct: 3786 LRTSCGNCSCAHGKLSCSLDDCFEA----DGGFGPWSPWGPCSRSCGGLGTRTRSRQCVL 3841

Query: 571  PPPQNGGSPCSGPASETLDC 590
              P   G  C GP  + L+C
Sbjct: 3842 TMPTLSGQGCRGPRQD-LEC 3860



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 19/57 (33%), Positives = 28/57 (49%), Gaps = 1/57 (1%)

Query: 96   HGEPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDE 152
            HG  C+  D +  D      C +    EG +   +G C+   LLC+  +DCGD +DE
Sbjct: 1392 HGWLCDNQD-DCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDE 1447



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 4/53 (7%)

Query: 62   PIDCELSSWSSWTTCDPCQ---KKRYRYAYLLQPSQFHGEPCNFSDKEVEDCV 111
            P +C  SSWSSWT C  C+   ++RYR+          G PC   D     C+
Sbjct: 4363 PEECVWSSWSSWTRCS-CRVLVQQRYRHQGPASRGARAGAPCTRLDGHFRPCL 4414



 Score = 33.9 bits (76), Expect = 0.43
 Identities = 28/95 (29%), Positives = 38/95 (40%), Gaps = 17/95 (17%)

Query: 500  VSSCHCAPCQGNG---VPVLKGSRCDCI-CPVGSQGLACEVSYRKNTPIDGKWNCWSNWS 555
            +SSC C     N    +   +  + DC  C   ++ L C     +  P+ G W   S WS
Sbjct: 4720 ISSCRCGLPSANASWELAPAQAVQLDCQNCTCVNESLVCP---HQECPVLGPW---SAWS 4773

Query: 556  SCS----GRRKTRQRQCNNPPPQNGGSPCSGPASE 586
            SCS    G    R R C   P   G +PC    +E
Sbjct: 4774 SCSAPCGGGTMERHRTCEGGP---GVAPCQAQDTE 4805



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 32/95 (33%)

Query: 506  APCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGR----- 560
            APC+G+    L+G  C  +C                T + G W  W++WSSCS       
Sbjct: 2752 APCEGDRQE-LQG--CHTVC---------------GTEVFG-WTPWTSWSSCSQSCLAPG 2792

Query: 561  ----RKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
                 ++R R C +P    G S C G A++   CS
Sbjct: 2793 GGPGWRSRSRLCPSP----GDSSCPGDATQEEPCS 2823



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 3/48 (6%)

Query: 108  EDCVTN---RPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDE 152
            EDC      R CG         CA+   CV+   LC+G   C D SDE
Sbjct: 1588 EDCADGSDERGCGGPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDE 1635



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 29/129 (22%), Positives = 44/129 (34%), Gaps = 13/129 (10%)

Query: 31   RGERPHSFGSNAVNKSFAKSRQMRSVDVTLMPIDCELSSWSSWTTC-DPCQKKRYRYAYL 89
            R  R    G   +        Q ++      P+D E S+WS W+ C +PC+    R    
Sbjct: 1717 RSRRCSPLGLLVLQNCPGPEHQSQACFTAACPVDGEWSTWSPWSVCSEPCRGTMTRQRQC 1776

Query: 90   LQPSQFHGEPCNFSDKEVEDCVTNRPCGS----QVRCEGFV-------CAQTGRCVNRRL 138
              P Q  G  C      +      +PC         C G +       C  T   ++ ++
Sbjct: 1777 HSP-QNGGRTCAALPGGLHSTRQTKPCPQDGCPNATCSGELMFQPCAPCPLTCDDISGQV 1835

Query: 139  LCNGDNDCG 147
             C  D  CG
Sbjct: 1836 TCPPDWPCG 1844



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 20/59 (33%), Positives = 28/59 (47%), Gaps = 6/59 (10%)

Query: 62   PIDCELSSWSSWTTCD-PCQ---KKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPC 116
            P+ C  S W+ W+ C   C    ++R+R A    P+ F G  C     E E C + RPC
Sbjct: 2983 PVACGWSPWTLWSLCSCSCNVGIRRRFR-AGTAPPAAFGGAECQGPTMEAEFC-SLRPC 3039



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 20/59 (33%), Positives = 26/59 (44%), Gaps = 15/59 (25%)

Query: 517  KGSRCDCICPV----GSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKTRQRQCNNP 571
            +G R D  CP     G++G   E      T + G W  WS+WS CS       R C +P
Sbjct: 3852 RGPRQDLECPSPDCPGAEGSTVEPV----TGLPGGWGPWSSWSPCS-------RSCTDP 3899



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 16/42 (38%), Positives = 20/42 (47%), Gaps = 7/42 (16%)

Query: 115  PCGS-QVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            PCG  + RC       +G C  R   C+ + DC D SDE  C
Sbjct: 1564 PCGPFEFRCG------SGECTPRGWRCDQEEDCADGSDERGC 1599



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 12/25 (48%), Positives = 16/25 (64%)

Query: 133  CVNRRLLCNGDNDCGDQSDEANCRR 157
            CV +  +C+G  DC D SDE +C R
Sbjct: 2403 CVEQAQVCDGREDCLDGSDERHCAR 2427



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 30/82 (36%), Positives = 34/82 (41%), Gaps = 17/82 (20%)

Query: 505  CAPCQ---GNGVPVLKGSRCDCI--CPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCS- 558
            C+P Q   G+G  +    RCD    C  GS    C         +D     WS WSSCS 
Sbjct: 2464 CSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC---------VDCVLAPWSVWSSCSR 2514

Query: 559  --GRRKTRQRQCNNPPPQNGGS 578
              G   T QRQ    PP  GGS
Sbjct: 2515 SCGLGLTFQRQELLRPPLPGGS 2536



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 17/45 (37%), Positives = 20/45 (44%), Gaps = 1/45 (2%)

Query: 109  DCVTNRPCGSQVRC-EGFVCAQTGRCVNRRLLCNGDNDCGDQSDE 152
            D      C  QV C  G V    G C+    LC+G  DC D +DE
Sbjct: 1479 DAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADE 1523



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 16/32 (50%), Positives = 18/32 (56%), Gaps = 1/32 (3%)

Query: 124  GFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            G  CA +G CV R   C+G  DC D SDE  C
Sbjct: 2238 GLRCA-SGECVLRGGPCDGVLDCEDGSDEEGC 2268



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 15/53 (28%), Positives = 22/53 (41%), Gaps = 1/53 (1%)

Query: 62   PIDCELSSWSSWTTCDPCQKKRYR-YAYLLQPSQFHGEPCNFSDKEVEDCVTN 113
            P+D     W  W+ CD C  + +R  A    P+   G PC  +  +   C  N
Sbjct: 3470 PVDGAWGPWGPWSPCDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQEN 3522



 Score = 30.4 bits (67), Expect = 4.8
 Identities = 40/165 (24%), Positives = 54/165 (32%), Gaps = 25/165 (15%)

Query: 31   RGERPHSFGSNAVNKSFAKSRQMRSVDVTLMPIDCELSSWSSWTTCDPC----QKKRYRY 86
            R  RP   G +         ++ R  ++   P+    S WS W+ CD      Q  R R 
Sbjct: 3971 RAYRPPGPGGHWCPNILTAYQERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGQSLRSR- 4029

Query: 87   AYLLQPSQFHGEPCNFSDKEVEDCVTNRPC--GSQVRCEGFVCAQTGRCVNR------RL 138
            +    PS+  G PC     +   C    PC  G     E   CA   RC  R       +
Sbjct: 4030 SCSSPPSKNGGAPCAGERHQARLC-NPMPCEAGCPAGMEVVTCA--NRCPRRCSDLQEGI 4086

Query: 139  LCNGDNDC--------GDQSDEANCRRI-YKKCQHEMDQYWGIGS 174
            +C  D  C        G    +  C  I +  C       W  GS
Sbjct: 4087 VCQDDQVCQKGCRCPKGSLEQDGGCVPIGHCDCTDAQGHSWAPGS 4131



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 7/59 (11%)

Query: 63   IDCELSSWSSWTTC-DPCQKKRYRYAYLL----QPSQFHGEPCNFSDKEVEDCVTNRPC 116
            +DC  SSWS W  C  PC  +  ++++      +PS   G  C    ++   C T  PC
Sbjct: 1908 VDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSG-RGRQCRGIHRKARRCQT-EPC 1964


>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
          Length = 1170

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 38/95 (40%), Positives = 45/95 (47%), Gaps = 10/95 (10%)

Query: 505 CAPCQGNGVPVLKGSRCDCI---CPVGS-QGLACEVSY-RKNTPIDGKWNCWSNWSSCS- 558
           C+   GNG+   +G  CD +   C   S Q   C +    K    DG W+ WS WSSCS 
Sbjct: 391 CSTSCGNGIQQ-RGRSCDSLNNRCEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSV 449

Query: 559 ---GRRKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
                  TR R CN+P PQ  G PC G A ET  C
Sbjct: 450 TCGDGVITRIRLCNSPSPQMNGKPCEGEARETKAC 484



 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 34/98 (34%), Positives = 44/98 (44%), Gaps = 13/98 (13%)

Query: 505 CAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNT-------PIDGKWNCWSNWSSC 557
           C+   G+GV + +   C+   P    G  CE   R+         PI+G W  WS W  C
Sbjct: 447 CSVTCGDGV-ITRIRLCNSPSPQ-MNGKPCEGEARETKACKKDACPINGGWGPWSPWDIC 504

Query: 558 S----GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           S    G  + R R CNNP PQ GG  C G  +E   C+
Sbjct: 505 SVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICN 542



 Score = 36.6 bits (83), Expect = 0.067
 Identities = 28/99 (28%), Positives = 37/99 (37%), Gaps = 21/99 (21%)

Query: 501 SSCHCAPCQGNGVPVLKGSRCD---CICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSC 557
           + CHC     N V + K   C    C       G  C   +  ++  DG W+ WS W+SC
Sbjct: 337 TECHCQ----NSVTICKKVSCPIMPCSNATVPDGECCPRCWPSDSADDG-WSPWSEWTSC 391

Query: 558 SGRRKTRQRQCNNPPPQNGGS------PCSGPASETLDC 590
           S         C N   Q G S       C G + +T  C
Sbjct: 392 S-------TSCGNGIQQRGRSCDSLNNRCEGSSVQTRTC 423


>gi|209977117 unc-5 homolog D [Homo sapiens]
          Length = 953

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 29/68 (42%), Positives = 38/68 (55%), Gaps = 7/68 (10%)

Query: 531 GLACE-VSYRKNT-----PIDGKWNCWSNWSSCSGR-RKTRQRQCNNPPPQNGGSPCSGP 583
           G  CE +S +K T     P+DG W  WS WS CS      R R+C  PPP+NGG  C G 
Sbjct: 288 GAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGL 347

Query: 584 ASETLDCS 591
           + E+ +C+
Sbjct: 348 SQESENCT 355



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 19/52 (36%), Positives = 31/52 (59%), Gaps = 4/52 (7%)

Query: 544 IDGKWNCWSNWSSCSGRR----KTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           ++G W+ W+ WS+C+ R     + R R C NP P NGG+ C G + + + C+
Sbjct: 251 VNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCT 302



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 19/67 (28%), Positives = 31/67 (46%), Gaps = 3/67 (4%)

Query: 46  SFAKSRQMRSVDVT-LMPIDCELSSWSSWTTCDP-CQKKRYRYAYLLQPSQFHGEPCNFS 103
           +F +   ++ +  T L P+D     WS W+ C P C+  R R      P +  G+ C   
Sbjct: 289 AFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIREC-TAPPPRNGGKFCEGL 347

Query: 104 DKEVEDC 110
            +E E+C
Sbjct: 348 SQESENC 354


>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
          Length = 1172

 Score = 56.6 bits (135), Expect = 6e-08
 Identities = 31/83 (37%), Positives = 42/83 (50%), Gaps = 10/83 (12%)

Query: 513 VPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCS----GRRKTRQRQC 568
           VP + G  C      G +  AC+ +     PIDG+W+ WS WS+C+    G  + R R C
Sbjct: 468 VPQMGGKNCK---GSGRETKACQGA---PCPIDGRWSPWSPWSACTVTCAGGIRERTRVC 521

Query: 569 NNPPPQNGGSPCSGPASETLDCS 591
           N+P PQ GG  C G   E   C+
Sbjct: 522 NSPEPQYGGKACVGDVQERQMCN 544



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 39/97 (40%), Positives = 48/97 (49%), Gaps = 14/97 (14%)

Query: 505 CAPCQGNGVPVLKGSRCD-----CICPVGSQGLACEVSYRKNTPI--DGKWNCWSNWSSC 557
           C+   G+G    +G  CD     C+ P   Q  AC +S + +T I  DG W+ WS WSSC
Sbjct: 393 CSVTCGSGTQQ-RGRSCDVTSNTCLGP-SIQTRACSLS-KCDTRIRQDGGWSHWSPWSSC 449

Query: 558 SGR----RKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
           S        TR R CN+P PQ GG  C G   ET  C
Sbjct: 450 SVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKAC 486



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 20/75 (26%), Positives = 31/75 (41%), Gaps = 14/75 (18%)

Query: 523 CICPVGSQGLACEVSYRKNTPIDGK--WNCWSNWSSCS----GRRKTRQRQCNNPPPQNG 576
           C  P   +G  C         +DG+  W+ W+ W+ CS       + R R C+       
Sbjct: 360 CASPSFVEGECCPSCLHS---VDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVT----- 411

Query: 577 GSPCSGPASETLDCS 591
            + C GP+ +T  CS
Sbjct: 412 SNTCLGPSIQTRACS 426



 Score = 29.6 bits (65), Expect = 8.1
 Identities = 24/89 (26%), Positives = 37/89 (41%), Gaps = 16/89 (17%)

Query: 51  RQMRSVDVTLMPIDCELSSWSSWT----TCDPCQKKRYRYAYLLQPSQFHG--------- 97
           R+ ++      PID   S WS W+    TC    ++R R     +P Q+ G         
Sbjct: 481 RETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNSPEP-QYGGKACVGDVQE 539

Query: 98  -EPCNFSDKEVEDCVTNRPCGSQVRCEGF 125
            + CN     V+ C++N PC    +C  F
Sbjct: 540 RQMCNKRSCPVDGCLSN-PCFPGAQCSSF 567


>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score = 56.2 bits (134), Expect = 8e-08
 Identities = 22/52 (42%), Positives = 33/52 (63%), Gaps = 4/52 (7%)

Query: 544 IDGKWNCWSNWSSCSGRR----KTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           ++G W+ W++WS CS       + R+R CNNP P+ GG PC GP+ E  +C+
Sbjct: 783 VNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECN 834



 Score = 53.5 bits (127), Expect = 5e-07
 Identities = 23/53 (43%), Positives = 29/53 (54%), Gaps = 4/53 (7%)

Query: 543 PIDGKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           P+DG W+CWS W+ CS    G    R R C+NP P  GG  C G  +E   C+
Sbjct: 839 PVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCN 891



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 22/59 (37%), Positives = 30/59 (50%), Gaps = 7/59 (11%)

Query: 540 KNTPIDGKWNCWSNWSSCS-------GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           +N  +DG +  WS W+ C+       G    R R C++P PQ GG  C GP  E  +CS
Sbjct: 535 RNLTVDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCS 593



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/55 (38%), Positives = 29/55 (52%), Gaps = 4/55 (7%)

Query: 541 NTPIDGKWNCWSNWSSCSGRR----KTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           N   +G W  W++WS CS       + RQR C+NP P++GG  C G   E   C+
Sbjct: 591 NCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCN 645



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 31/114 (27%), Positives = 41/114 (35%), Gaps = 24/114 (21%)

Query: 499 EVSSCHCAPCQGNGVPVLKG--SRCDCICPVGSQ-------------------GLACEVS 537
           E   C+  PC  +GV       ++C   C  G                     GL  E +
Sbjct: 829 EYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEA 888

Query: 538 YRKNTPIDGKWNCWSNWSSCSGRR-KTRQRQCNNPPPQNGGSPCSGPASETLDC 590
                P    W+ WS+WS C     + R RQC    P   GS CSG  +E+  C
Sbjct: 889 LCNTQPCPESWSEWSDWSECEASGVQVRARQCILLFPM--GSQCSGNTTESRPC 940


>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
          Length = 1151

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 24/52 (46%), Positives = 30/52 (57%), Gaps = 4/52 (7%)

Query: 544 IDGKWNCWSNWSSCSGRR----KTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           + G W  W  WSSCS       + R+R C NP P+NGG PC G A+E  DC+
Sbjct: 852 VSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCN 903



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 30/96 (31%), Positives = 44/96 (45%), Gaps = 12/96 (12%)

Query: 507 PCQ-----GNGVPVLKGSRCDCICPVGSQGLAC--EVSYRKNTPIDGKWNCWSNWSSCSG 559
           PC+      +G  + +   CD   P    GL C     +  N   +G W  WS+W+ CS 
Sbjct: 620 PCEHLDGDNSGSCLCRARSCDSPRP-RCGGLDCLGPAIHIANCSRNGAWTPWSSWALCST 678

Query: 560 RR----KTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
                 + RQR C+NP P++GG  C G + E   C+
Sbjct: 679 SCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCN 714



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 20/53 (37%), Positives = 27/53 (50%), Gaps = 4/53 (7%)

Query: 543 PIDGKWNCWSNWS----SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           P+ G W+CW++WS    SC G    R R C +P P  G   C G  +E   C+
Sbjct: 908 PVRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCA 960



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 16/44 (36%), Positives = 24/44 (54%), Gaps = 3/44 (6%)

Query: 548  WNCWSNWSSCS-GRRKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
            W+ WS WS C+    ++R R C    P  G S C+G +S++  C
Sbjct: 968  WSPWSEWSKCTDDGAQSRSRHCEELLP--GSSACAGNSSQSRPC 1009



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 32/116 (27%), Positives = 42/116 (36%), Gaps = 34/116 (29%)

Query: 504 HCAPCQGNGV--PVLKGSRCDCICPVGSQ--------------GLACEVSYRK------N 541
           H A C  NG   P    + C   C +G Q              G  C    R+      N
Sbjct: 657 HIANCSRNGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNEN 716

Query: 542 TP--IDGKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           TP  +   W  W +WS CS    G  ++R+R C N      G+ C G   E   C+
Sbjct: 717 TPCPVPIFWASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCN 766


>gi|16933525 unc5C [Homo sapiens]
          Length = 931

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 30/97 (30%), Positives = 46/97 (47%), Gaps = 14/97 (14%)

Query: 496 FQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWS 555
           +QK   +C       N  P+  G+ C+       Q +AC        P+DG+W  WS WS
Sbjct: 280 YQKRTRTCT------NPAPLNGGAFCE---GQSVQKIACTTL----CPVDGRWTPWSKWS 326

Query: 556 SCSGR-RKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           +C       R+R+C  P P+NGG  C G   ++ +C+
Sbjct: 327 TCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCT 363



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 23/66 (34%), Positives = 36/66 (54%), Gaps = 10/66 (15%)

Query: 536 VSYRKNTP------IDGKWNCWSNWSSCSGR----RKTRQRQCNNPPPQNGGSPCSGPAS 585
           V+ RK+T       ++G W+ W+ WS C+ R     + R R C NP P NGG+ C G + 
Sbjct: 245 VAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSV 304

Query: 586 ETLDCS 591
           + + C+
Sbjct: 305 QKIACT 310


>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
           18 preproprotein [Homo sapiens]
          Length = 1221

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/79 (36%), Positives = 39/79 (49%), Gaps = 5/79 (6%)

Query: 508 CQGNGVPVLKGSRCDCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCS----GRRKT 563
           C+   +P  +G+ C  +     QG   +       PI G+W+ WS WS CS    G  K 
Sbjct: 553 CETKFMPAAEGTVCG-LSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKF 611

Query: 564 RQRQCNNPPPQNGGSPCSG 582
           ++R CNNP PQ GG  C G
Sbjct: 612 QERHCNNPKPQYGGLFCPG 630


>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
          Length = 1522

 Score = 52.8 bits (125), Expect = 9e-07
 Identities = 40/114 (35%), Positives = 53/114 (46%), Gaps = 17/114 (14%)

Query: 487 QNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQ--GLACEVSYRKNT-- 542
           Q  +  +EE+  + S+C     QG+ V         C+ P G+   G   E     NT  
Sbjct: 288 QTGESGVEEWS-QWSTCSVTCGQGSQVRTRT-----CVSPYGTHCSGPLRESRVCNNTAL 341

Query: 543 -PIDGKWNCWSNWSSCS---GR-RKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
            P+ G W  WS WS CS   GR ++TR R C   PPQ GG PC GP +    C+
Sbjct: 342 CPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCT--PPQYGGRPCEGPETHHKPCN 393



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 22/52 (42%), Positives = 31/52 (59%), Gaps = 6/52 (11%)

Query: 543 PIDGKWNCWSNWS----SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDC 590
           P+DG+W  WS+WS    +CS   + R RQC      +GGS C GP +E+ +C
Sbjct: 398 PVDGQWQEWSSWSQCSVTCSNGTQQRSRQCT--AAAHGGSECRGPWAESREC 447



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 19/58 (32%), Positives = 23/58 (39%), Gaps = 6/58 (10%)

Query: 538 YRKNTPIDGKWNCWSNWS----SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           Y      +G+WN W +WS    SC G  + R R C        G  C G   E   CS
Sbjct: 448 YNPECTANGQWNQWGHWSGCSKSCDGGWERRIRTCQGAVIT--GQQCEGTGEEVRRCS 503


>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
           motif, 17 preproprotein [Homo sapiens]
          Length = 1095

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 32/89 (35%), Positives = 40/89 (44%), Gaps = 10/89 (11%)

Query: 508 CQGNGVPVLKGSRC--DCICPVGSQGLACEVSYRKNTPIDGKWNCWSNWSSCSGRRKT-- 563
           C+    P L G+ C  D  C  G     C         +DG W+ W  WS CS    T  
Sbjct: 508 CKTKLDPPLDGTECGADKWCRAGE----CVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGA 563

Query: 564 --RQRQCNNPPPQNGGSPCSGPASETLDC 590
             RQR+C+NPPP  GG+ C G + E   C
Sbjct: 564 RFRQRKCDNPPPGPGGTHCPGASVEHAVC 592


>gi|62243567 netrin receptor Unc5h1 [Homo sapiens]
          Length = 842

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 20/49 (40%), Positives = 30/49 (61%), Gaps = 1/49 (2%)

Query: 544 IDGKWNCWSNWSSCS-GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           +DG W+ WS WS+C       R R+C++P P+NGG  C G   +T +C+
Sbjct: 241 VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCT 289


>gi|93102379 low density lipoprotein-related protein 1B precursor
            [Homo sapiens]
          Length = 4599

 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 24/56 (42%), Positives = 34/56 (60%), Gaps = 4/56 (7%)

Query: 104  DKEVEDCVTNRPCGSQVR-CEG---FVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            +K+ ED    + C   +R C+    F C  TGRC+N+  +C+GD DC DQSDE +C
Sbjct: 1076 EKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDC 1131



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 23/67 (34%), Positives = 35/67 (52%), Gaps = 8/67 (11%)

Query: 103 SDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKC 162
           SD++  +C  +     Q +C      Q  RC+ +R LC+G NDCG   DE+N     + C
Sbjct: 874 SDEDSVNCFNHSCPDDQFKC------QNNRCIPKRWLCDGANDCGSNEDESNQTCTARTC 927

Query: 163 QHEMDQY 169
           Q  +DQ+
Sbjct: 928 Q--VDQF 932



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 24/67 (35%), Positives = 31/67 (46%), Gaps = 3/67 (4%)

Query: 101  NFSDKEVEDCVTNRPCGSQVRCEG--FVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRI 158
            +FSD+   +C T     S   C G  F C   G CV     C+G+ DC D SDE  C   
Sbjct: 1033 DFSDEAQINC-TKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGT 1091

Query: 159  YKKCQHE 165
             + C H+
Sbjct: 1092 IRLCDHK 1098



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 23/60 (38%), Positives = 30/60 (50%), Gaps = 10/60 (16%)

Query: 98   EPCNFSDKEVEDCVTNRPCGSQVRCEG--FVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            + C     E +DC        + RC+   F C  TG C     +C+G+NDCGD SDE NC
Sbjct: 3340 DDCGDGSDEPDDC-------PEFRCQPGRFQCG-TGLCALPAFICDGENDCGDNSDELNC 3391



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 6/54 (11%)

Query: 103  SDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCR 156
            SD+++  C  NR C       GF      RC+    LC+G+NDCGD SDE +C+
Sbjct: 2540 SDEKLLYC-ENRSCR-----RGFKPCYNRRCIPHGKLCDGENDCGDNSDELDCK 2587



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 20/51 (39%), Positives = 27/51 (52%), Gaps = 4/51 (7%)

Query: 109  DCVTNRP---CGSQVRCEG-FVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            DC  N     C + V   G F C +  +C+   L CNG +DCGD+ DE +C
Sbjct: 3381 DCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 20/39 (51%), Positives = 23/39 (58%), Gaps = 1/39 (2%)

Query: 125  FVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQ 163
            F+CA  G CV+ R  C+GD DC D SDE NC     K Q
Sbjct: 3520 FLCAN-GDCVSSRFWCDGDFDCADGSDERNCETSCSKDQ 3557



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 32/118 (27%), Positives = 48/118 (40%), Gaps = 11/118 (9%)

Query: 100  CNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIY 159
            CN  + +  D      C ++ + + F C     C+  R LC+G +DC D SDE NC R  
Sbjct: 3613 CN-GEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGG 3671

Query: 160  KKCQHEMDQYWGIGSLA--------SGINLFTNSFEGPVLDHRYYAGGCSPHYILNTR 209
              C+   D++    SL            +   NS E P +  ++      PH   N R
Sbjct: 3672 NICR--ADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHRCRNNR 3727



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 22/57 (38%), Positives = 32/57 (56%), Gaps = 6/57 (10%)

Query: 100 CNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDE-ANC 155
           C  ++ E     T R C    + + F C   GRC+ R  LC+ ++DCGDQ+DE A+C
Sbjct: 911 CGSNEDESNQTCTARTC----QVDQFSCGN-GRCIPRAWLCDREDDCGDQTDEMASC 962



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 16/31 (51%), Positives = 23/31 (74%), Gaps = 1/31 (3%)

Query: 125  FVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            FVC ++GRC++ +  C+ D+DCGD SDE  C
Sbjct: 973  FVC-KSGRCISSKWHCDSDDDCGDGSDEVGC 1002



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 18/37 (48%), Positives = 22/37 (59%), Gaps = 1/37 (2%)

Query: 120  VRCEGFV-CAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            V+  GF+ C  T  CV    +C+G NDCGD SDE  C
Sbjct: 2638 VKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKC 2674



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 30/79 (37%), Positives = 37/79 (46%), Gaps = 14/79 (17%)

Query: 92   PSQF---HGEPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCV-NRRLLCNGDNDCG 147
            P QF   H + C     E   C   R CG+    E F CA  GRC+ N +  C+GD DC 
Sbjct: 2819 PKQFVCDHDDDCGDGSDESPQC-GYRQCGT----EEFSCAD-GRCLLNTQWQCDGDFDCP 2872

Query: 148  DQSDEA----NCRRIYKKC 162
            D SDEA     C+   + C
Sbjct: 2873 DHSDEAPLNPKCKSAEQSC 2891



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 20/58 (34%), Positives = 30/58 (51%), Gaps = 5/58 (8%)

Query: 98   EPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            E C + + E      +  C S+     ++CA  G C++  L CNG+ DC D SDE +C
Sbjct: 3576 EDCKYGEDEKSCEPASPTCSSRE----YICASDG-CISASLKCNGEYDCADGSDEMDC 3628



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 20/42 (47%), Positives = 25/42 (59%), Gaps = 8/42 (19%)

Query: 118  SQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEA--NCRR 157
            +Q RC       +GRC+     C+GDNDCGD SDEA  NC +
Sbjct: 1009 NQFRCS------SGRCIPGHWACDGDNDCGDFSDEAQINCTK 1044



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 7/70 (10%)

Query: 103 SDKEVEDCVTNRPCGSQVRC--EGFVCAQTGRCVNRRLLCNGDNDCGDQSDE-ANCRRIY 159
           SD+ ++ C    P   +++C      C  T +CV+   LCNG  DC D  DE  +C+ + 
Sbjct: 62  SDESLDTC----PEEVEIKCPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELL 117

Query: 160 KKCQHEMDQY 169
             CQ    QY
Sbjct: 118 SNCQQLNCQY 127



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 15/31 (48%), Positives = 20/31 (64%)

Query: 125  FVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            F C  T  C+++  +C+ D DC D SDEANC
Sbjct: 3441 FQCKTTKHCISKLWVCDEDPDCADASDEANC 3471



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 16/31 (51%), Positives = 21/31 (67%), Gaps = 1/31 (3%)

Query: 125  FVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            F+C + GRC+    LC+  +DCGD SDE NC
Sbjct: 2896 FMC-KNGRCIPSGGLCDNKDDCGDGSDERNC 2925



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 24/75 (32%), Positives = 32/75 (42%), Gaps = 15/75 (20%)

Query: 96   HGEPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQT------GRCVNRRLLCNGDNDCGDQ 149
            HG+ C+  +    DC  N     ++ C+   CA        G C+ R   CN + DC D 
Sbjct: 2567 HGKLCDGEN----DCGDN---SDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADA 2619

Query: 150  SDEANCRRIYKKCQH 164
            SDE NC      C H
Sbjct: 2620 SDEKNCNN--TDCTH 2632



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 24/72 (33%), Positives = 36/72 (50%), Gaps = 11/72 (15%)

Query: 108  EDCVTNRPCGSQVRCEGFVCAQTG--RCVNRRL------LCNGDNDCGDQSDEANC--RR 157
            +DC  N      + C  F+C  T   RC N R+      +CNG ++CGD SDE +C  + 
Sbjct: 3697 DDCGDNSDEAPDM-CVKFLCPSTRPHRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKL 3755

Query: 158  IYKKCQHEMDQY 169
             YK    + D++
Sbjct: 3756 TYKARPCKKDEF 3767



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 16/50 (32%), Positives = 28/50 (56%), Gaps = 1/50 (2%)

Query: 105  KEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEAN 154
            K+ ED      C S      F C+   +C+++  +C+G++DCGD  DE++
Sbjct: 2705 KDCEDGRDEFHCDSSCSWNQFACSAQ-KCISKHWICDGEDDCGDGLDESD 2753



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 14/29 (48%), Positives = 19/29 (65%)

Query: 125 FVCAQTGRCVNRRLLCNGDNDCGDQSDEA 153
           F+C     CV++  LC+GD DC D SDE+
Sbjct: 37  FLCHDHVTCVSQSWLCDGDPDCPDDSDES 65



 Score = 34.7 bits (78), Expect = 0.25
 Identities = 14/42 (33%), Positives = 23/42 (54%), Gaps = 1/42 (2%)

Query: 115  PCGSQVRCE-GFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            P  ++ +CE  +    +GRC+    +C+G  DC D  DE +C
Sbjct: 2675 PVQNKHKCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC 2716



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 22/61 (36%), Positives = 30/61 (49%), Gaps = 12/61 (19%)

Query: 110  CVT-NRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDE-------ANCRRIYKK 161
            CVT N  C +      F C   G C++ +L C+G   C D+SDE        +CRR +K 
Sbjct: 2503 CVTKNSSCNAYSE---FECGN-GECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKP 2558

Query: 162  C 162
            C
Sbjct: 2559 C 2559



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 17/39 (43%), Positives = 22/39 (56%), Gaps = 3/39 (7%)

Query: 116  CGSQVRCEG--FVCAQTGRCVNRRLLCNGDNDCGDQSDE 152
            CG+ + C    F C  +  CV R  LC+G+ DC D SDE
Sbjct: 2756 CGA-ITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDE 2793



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 19/57 (33%), Positives = 29/57 (50%), Gaps = 8/57 (14%)

Query: 110  CVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEA-NCRRIYKKCQHE 165
            C  N  C        F+C     C+ ++ +C+ D+DCGD SDE+  C   Y++C  E
Sbjct: 2799 CAPNNTCDENA----FMC-HNKVCIPKQFVCDHDDDCGDGSDESPQCG--YRQCGTE 2848



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 5/43 (11%)

Query: 114  RPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCR 156
            RPC    + + F C+   +C+   L C+  +DCGD SDE  CR
Sbjct: 3760 RPC----KKDEFACSNK-KCIPMDLQCDRLDDCGDGSDEQGCR 3797



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 13/32 (40%), Positives = 17/32 (53%), Gaps = 1/32 (3%)

Query: 125  FVCAQTGRCVNRRLLCNGDNDCGDQSDEANCR 156
            F C +   C+     C+  NDC D SDE NC+
Sbjct: 3481 FQC-KNNNCIPDHWRCDSQNDCSDNSDEENCK 3511



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 15/39 (38%), Positives = 18/39 (46%), Gaps = 8/39 (20%)

Query: 122  CEGFVCA--------QTGRCVNRRLLCNGDNDCGDQSDE 152
            C+ F+C          T  C+    LCNG  DC D SDE
Sbjct: 1131 CDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 4/64 (6%)

Query: 89   LLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGD 148
            LL P + H   C  +     D   NR C S      F C +T +C+     C+  +DCGD
Sbjct: 3289 LLAPGKTHTCACPTNFYLAAD---NRTCLSNCTASQFRC-KTDKCIPFWWKCDTVDDCGD 3344

Query: 149  QSDE 152
             SDE
Sbjct: 3345 GSDE 3348



 Score = 31.2 bits (69), Expect = 2.8
 Identities = 16/59 (27%), Positives = 25/59 (42%), Gaps = 1/59 (1%)

Query: 104  DKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKC 162
            D +  D    R C +    + F C+  G+C+  +  C+G  DC    DE +C      C
Sbjct: 3537 DFDCADGSDERNCETSCSKDQFRCSN-GQCIPAKWKCDGHEDCKYGEDEKSCEPASPTC 3594



 Score = 30.8 bits (68), Expect = 3.7
 Identities = 19/62 (30%), Positives = 27/62 (43%), Gaps = 11/62 (17%)

Query: 96  HGEPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDE--A 153
           +G  C F+  E    +       + RC+         C+  R  C+GD+DC D SDE   
Sbjct: 829 NGTTCTFNPGEALPHICK---AGEFRCKN------RHCIQARWKCDGDDDCLDGSDEDSV 879

Query: 154 NC 155
           NC
Sbjct: 880 NC 881


>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
           [Homo sapiens]
          Length = 1584

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 34/122 (27%), Positives = 47/122 (38%), Gaps = 30/122 (24%)

Query: 497 QKEVSSCHCAPCQGNGVPV-----LKGSRCDCICPVGSQ------------GLACEVS-- 537
           +K+   C+ A C G  V          S C   C  G Q            G  C+    
Sbjct: 450 EKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWV 509

Query: 538 -----YRKNTPIDGKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSGPASETL 588
                + +  P+DGKW  W++W SCS       + R+R C+   P  GG+ C GP  E  
Sbjct: 510 ETRDCFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSG--PFFGGAACQGPQDEYR 567

Query: 589 DC 590
            C
Sbjct: 568 QC 569



 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 23/51 (45%), Positives = 28/51 (54%), Gaps = 2/51 (3%)

Query: 543 PIDGKWNCWSNWSSCSGR--RKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           P+ G W+ WS WS CS    R  R R     PPQ GG+PC GP  +T  C+
Sbjct: 407 PVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCN 457



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 18/50 (36%), Positives = 21/50 (42%), Gaps = 5/50 (10%)

Query: 546 GKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
           G W  WS W  C+    G  +TR R C   P   GG  C G   E   C+
Sbjct: 262 GGWKLWSLWGECTRDCGGGLQTRTRTCLPAPGVEGGG-CEGVLEEGRQCN 310



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 21/81 (25%), Positives = 31/81 (38%), Gaps = 7/81 (8%)

Query: 34  RPHSFGSNAVNKSFAKSRQMRSVDVTLMP---IDCELSSWSSWTTCD-PCQKKRYRYAYL 89
           RP  FG N         +Q +  ++ L P   +D   + WSSW+ C   C + R +    
Sbjct: 437 RPPQFGGNPCE---GPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRE 493

Query: 90  LQPSQFHGEPCNFSDKEVEDC 110
                + G  C     E  DC
Sbjct: 494 CNGPSYGGAECQGHWVETRDC 514



 Score = 31.6 bits (70), Expect = 2.1
 Identities = 14/50 (28%), Positives = 22/50 (44%), Gaps = 1/50 (2%)

Query: 62  PIDCELSSWSSWTTCDPCQKKRYR-YAYLLQPSQFHGEPCNFSDKEVEDC 110
           P+      WS W+ C     + +R      +P QF G PC   +K+ + C
Sbjct: 407 PVHGAWDEWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFC 456


>gi|4507157 sortilin-related receptor containing LDLR class A repeats
            preproprotein [Homo sapiens]
          Length = 2214

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 21/45 (46%), Positives = 29/45 (64%), Gaps = 1/45 (2%)

Query: 119  QVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQ 163
            Q R + + C+ +G C+    +C+GDNDC D SDEANC  IY  C+
Sbjct: 1157 QCRSDEYNCS-SGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCE 1200



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 4/64 (6%)

Query: 104  DKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQ 163
            D + +D     P   + +C GF C   G C+     C+G  DC D SDE +C  +   C 
Sbjct: 1221 DTDCQDGSDEDPVNCEKKCNGFRCPN-GTCIPSSKHCDGLRDCSDGSDEQHCEPL---CT 1276

Query: 164  HEMD 167
            H MD
Sbjct: 1277 HFMD 1280



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 22/51 (43%), Positives = 25/51 (49%), Gaps = 11/51 (21%)

Query: 105  KEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            KE   C+ N     Q RC        G C+N    C+ DNDCGD SDE NC
Sbjct: 1073 KEENTCLRN-----QYRCSN------GNCINSIWWCDFDNDCGDMSDERNC 1112



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 18/32 (56%), Positives = 22/32 (68%), Gaps = 1/32 (3%)

Query: 124  GFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            GF C Q G C++    C+G +DCGD SDEANC
Sbjct: 1329 GFQC-QNGVCISLIWKCDGMDDCGDYSDEANC 1359



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 20/59 (33%), Positives = 33/59 (55%), Gaps = 5/59 (8%)

Query: 100  CNFSDKEVEDCVTNRPCGSQVRCE---GFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            C+F D +  D    R C + + C+    F C ++G C+     C+ ++DCGD SDE++C
Sbjct: 1097 CDF-DNDCGDMSDERNCPTTI-CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHC 1153



 Score = 38.5 bits (88), Expect = 0.018
 Identities = 17/37 (45%), Positives = 21/37 (56%), Gaps = 6/37 (16%)

Query: 119  QVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            Q RCE       G C+  R  C+ +NDCGD SDE +C
Sbjct: 1373 QFRCEN------GHCIPNRWKCDRENDCGDWSDEKDC 1403



 Score = 36.6 bits (83), Expect = 0.067
 Identities = 21/45 (46%), Positives = 25/45 (55%), Gaps = 8/45 (17%)

Query: 122  CEG--FVCAQTGRCVNRRLLCNGDNDCGDQSDE--ANCRRIYKKC 162
            CE   F C + G C+ +R  C+GD DC D SDE   NC    KKC
Sbjct: 1199 CEASNFQC-RNGHCIPQRWACDGDTDCQDGSDEDPVNCE---KKC 1239



 Score = 34.3 bits (77), Expect = 0.33
 Identities = 16/37 (43%), Positives = 19/37 (51%), Gaps = 2/37 (5%)

Query: 121  RCEGFV--CAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            RC+ F   C Q   C+     C+G  DC D  DEANC
Sbjct: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANC 1506



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 12/26 (46%), Positives = 15/26 (57%)

Query: 130  TGRCVNRRLLCNGDNDCGDQSDEANC 155
            +G CV    +C+G  DC D SDE  C
Sbjct: 1428 SGTCVMDTWVCDGYRDCADGSDEEAC 1453



 Score = 30.0 bits (66), Expect = 6.2
 Identities = 16/45 (35%), Positives = 20/45 (44%), Gaps = 2/45 (4%)

Query: 113  NRPCGSQVRCEG--FVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            N P  S + C    F C     C+     C+G  DC D+SDE  C
Sbjct: 1505 NCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549


>gi|110825974 ADAM metallopeptidase with thrombospondin type 1
           motif, 2 isoform 1 preproprotein [Homo sapiens]
          Length = 1211

 Score = 50.1 bits (118), Expect = 6e-06
 Identities = 25/51 (49%), Positives = 28/51 (54%), Gaps = 4/51 (7%)

Query: 545 DGKWNCWSNWSSCSGRRKT----RQRQCNNPPPQNGGSPCSGPASETLDCS 591
           DG W  WS + SCS    T    R RQC+NP P NGG  CSG A +   CS
Sbjct: 561 DGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCS 611


>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
           13 isoform 3 preproprotein [Homo sapiens]
          Length = 1340

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 36/104 (34%), Positives = 44/104 (42%), Gaps = 19/104 (18%)

Query: 502 SCHCAP-----CQGNGVPVLKGSRC--DCICPVGSQGLACEVSYRKNTPIDGKWNCWSNW 554
           SCH  P     C    VP+L G+ C  +  C  G      E+     TPI      WS+W
Sbjct: 305 SCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVEL-----TPIAAVHGRWSSW 359

Query: 555 S-------SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
                   SC G   TR+RQCNNP P  GG  C G   +   C+
Sbjct: 360 GPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN 403



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 35/125 (28%), Positives = 50/125 (40%), Gaps = 14/125 (11%)

Query: 18  LCAALGCLSLP-----GSRGERPHSFGSNAVNKSFAKSRQMRSVDVTLMPIDCELSSWSS 72
           +C AL C + P      SR   P   G+    + +    + RS+ V L PI      WSS
Sbjct: 300 MCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSL-VELTPIAAVHGRWSS 358

Query: 73  WTTCDPCQKK-------RYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQVRCEGF 125
           W    PC +        R R     +P+ F G  C  +D + E C T     +Q+     
Sbjct: 359 WGPRSPCSRSCGGGVVTRRRQCNNPRPA-FGGRACVGADLQAEMCNTQACEKTQLEFMSQ 417

Query: 126 VCAQT 130
            CA+T
Sbjct: 418 QCART 422


>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
           13 isoform 2 preproprotein [Homo sapiens]
          Length = 1371

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 36/104 (34%), Positives = 44/104 (42%), Gaps = 19/104 (18%)

Query: 502 SCHCAP-----CQGNGVPVLKGSRC--DCICPVGSQGLACEVSYRKNTPIDGKWNCWSNW 554
           SCH  P     C    VP+L G+ C  +  C  G      E+     TPI      WS+W
Sbjct: 336 SCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVEL-----TPIAAVHGRWSSW 390

Query: 555 S-------SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
                   SC G   TR+RQCNNP P  GG  C G   +   C+
Sbjct: 391 GPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN 434



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 35/125 (28%), Positives = 50/125 (40%), Gaps = 14/125 (11%)

Query: 18  LCAALGCLSLP-----GSRGERPHSFGSNAVNKSFAKSRQMRSVDVTLMPIDCELSSWSS 72
           +C AL C + P      SR   P   G+    + +    + RS+ V L PI      WSS
Sbjct: 331 MCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSL-VELTPIAAVHGRWSS 389

Query: 73  WTTCDPCQKK-------RYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQVRCEGF 125
           W    PC +        R R     +P+ F G  C  +D + E C T     +Q+     
Sbjct: 390 WGPRSPCSRSCGGGVVTRRRQCNNPRPA-FGGRACVGADLQAEMCNTQACEKTQLEFMSQ 448

Query: 126 VCAQT 130
            CA+T
Sbjct: 449 QCART 453


>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
           13 isoform 1 preproprotein [Homo sapiens]
          Length = 1427

 Score = 49.7 bits (117), Expect = 8e-06
 Identities = 36/104 (34%), Positives = 44/104 (42%), Gaps = 19/104 (18%)

Query: 502 SCHCAP-----CQGNGVPVLKGSRC--DCICPVGSQGLACEVSYRKNTPIDGKWNCWSNW 554
           SCH  P     C    VP+L G+ C  +  C  G      E+     TPI      WS+W
Sbjct: 336 SCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVEL-----TPIAAVHGRWSSW 390

Query: 555 S-------SCSGRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
                   SC G   TR+RQCNNP P  GG  C G   +   C+
Sbjct: 391 GPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCN 434



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 35/125 (28%), Positives = 50/125 (40%), Gaps = 14/125 (11%)

Query: 18  LCAALGCLSLP-----GSRGERPHSFGSNAVNKSFAKSRQMRSVDVTLMPIDCELSSWSS 72
           +C AL C + P      SR   P   G+    + +    + RS+ V L PI      WSS
Sbjct: 331 MCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSL-VELTPIAAVHGRWSS 389

Query: 73  WTTCDPCQKK-------RYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQVRCEGF 125
           W    PC +        R R     +P+ F G  C  +D + E C T     +Q+     
Sbjct: 390 WGPRSPCSRSCGGGVVTRRRQCNNPRPA-FGGRACVGADLQAEMCNTQACEKTQLEFMSQ 448

Query: 126 VCAQT 130
            CA+T
Sbjct: 449 QCART 453


>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
           9 preproprotein [Homo sapiens]
          Length = 1935

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 35/122 (28%), Positives = 50/122 (40%), Gaps = 17/122 (13%)

Query: 479 FAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVPVLKGSRCDCICPVGSQGLACEVSY 538
           F   S V   M Q    +   V+  H   C+    P   G+ C+        G  C+  +
Sbjct: 525 FGPGSQVCPYMMQCRRLWCNNVNGVHKG-CRTQHTPWADGTECE-------PGKHCKYGF 576

Query: 539 ----RKNTPI-DGKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSGPASETLD 589
                 + P+ DG W  WS + +CS    G  KT  R+CN P P+NGG  C G   +   
Sbjct: 577 CVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRRMKFKS 636

Query: 590 CS 591
           C+
Sbjct: 637 CN 638


>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
           1 preproprotein [Homo sapiens]
          Length = 967

 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 30/94 (31%), Positives = 38/94 (40%), Gaps = 15/94 (15%)

Query: 508 CQGNGVPVLKGSRCD----CICPVGSQGLACEVSYRKN--TPIDGKWNCWSNWSSCS--- 558
           CQ    P   G+ C     CI      G     + RK+  TP  G W  W  W  CS   
Sbjct: 521 CQTKHFPWADGTSCGEGKWCI-----NGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTC 575

Query: 559 -GRRKTRQRQCNNPPPQNGGSPCSGPASETLDCS 591
            G  +   R+C+NP P+NGG  C G       C+
Sbjct: 576 GGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCN 609


>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
           motif, 16 preproprotein [Homo sapiens]
          Length = 1224

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 32/107 (29%), Positives = 46/107 (42%), Gaps = 14/107 (13%)

Query: 487 QNMKQALEEFQKEVSS---CHCA--PCQGNGVPVLKGSRC--DCICPVGSQGLACEVSYR 539
           +  K  + +F+K++     CH     C+   +P  +G+ C  D  C  G      +    
Sbjct: 524 EKAKLCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQ---CVKYGDE 580

Query: 540 KNTPIDGKWNCWSNWSSCS----GRRKTRQRQCNNPPPQNGGSPCSG 582
              P  G W+ WS+WS CS    G    R R C NP P +GG  C G
Sbjct: 581 GPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEG 627


>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
          Length = 4544

 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/87 (35%), Positives = 43/87 (49%), Gaps = 6/87 (6%)

Query: 73   WTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRPCGSQV-RCEG---FVCA 128
            + TC P +  R      L   Q+  +  N    + ++   N  C SQ  +C     F+C+
Sbjct: 2855 YPTCGPSEF-RCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCS 2913

Query: 129  QTGRCVNRRLLCNGDNDCGDQSDEANC 155
             +GRCV   LLCNG +DCGD SDE  C
Sbjct: 2914 -SGRCVAEALLCNGQDDCGDSSDERGC 2939



 Score = 47.0 bits (110), Expect = 5e-05
 Identities = 23/58 (39%), Positives = 28/58 (48%), Gaps = 6/58 (10%)

Query: 98   EPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            + C     E  DC   +    Q +C       TG C N   +C+GDNDC D SDEANC
Sbjct: 3357 DDCGDHSDEPPDCPEFKCRPGQFQCS------TGICTNPAFICDGDNDCQDNSDEANC 3408



 Score = 46.6 bits (109), Expect = 6e-05
 Identities = 27/66 (40%), Positives = 35/66 (53%), Gaps = 10/66 (15%)

Query: 104  DKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQ 163
            D   E+  T RPC        F CA  GRC+  R  C+GD+DC D SDE +C     +C 
Sbjct: 3563 DNSDEESCTPRPCSESE----FSCAN-GRCIAGRWKCDGDHDCADGSDEKDCT---PRC- 3613

Query: 164  HEMDQY 169
             +MDQ+
Sbjct: 3614 -DMDQF 3618



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 16/34 (47%), Positives = 23/34 (67%)

Query: 125  FVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRI 158
            F C  + RC+++  +C+GDNDC D SDE NC  +
Sbjct: 1110 FGCKDSARCISKAWVCDGDNDCEDNSDEENCESL 1143



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 18/31 (58%), Positives = 20/31 (64%), Gaps = 1/31 (3%)

Query: 125  FVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            F C   GRC+N    C+ DNDCGD SDEA C
Sbjct: 982  FTC-NNGRCININWRCDNDNDCGDNSDEAGC 1011



 Score = 43.1 bits (100), Expect = 7e-04
 Identities = 22/55 (40%), Positives = 27/55 (49%), Gaps = 3/55 (5%)

Query: 103  SDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDE--ANC 155
            +D +  D      C        F C  +GRC+     C+GDNDCGD SDE  ANC
Sbjct: 998  NDNDCGDNSDEAGCSHSCSSTQFKC-NSGRCIPEHWTCDGDNDCGDYSDETHANC 1051



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 22/64 (34%), Positives = 31/64 (48%), Gaps = 3/64 (4%)

Query: 101  NFSDKEVEDCVTN--RPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRI 158
            ++SD+   +C     RP G     + F C   G C+  R  C+GD DC D SDE +C  +
Sbjct: 1042 DYSDETHANCTNQATRPPGG-CHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGV 1100

Query: 159  YKKC 162
               C
Sbjct: 1101 THVC 1104



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 19/42 (45%), Positives = 24/42 (57%)

Query: 116  CGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRR 157
            C S+   + F     GRCV+  L CNG +DCGD SDE  C +
Sbjct: 2561 CNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNK 2602



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 21/49 (42%), Positives = 31/49 (63%), Gaps = 5/49 (10%)

Query: 109  DCV--TNRPCG-SQVRC--EGFVCAQTGRCVNRRLLCNGDNDCGDQSDE 152
            DCV  ++ P   +Q+ C  + F C  +GRC+  R  C+G++DCGD SDE
Sbjct: 3478 DCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDE 3526



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 24/54 (44%), Positives = 29/54 (53%), Gaps = 8/54 (14%)

Query: 103  SDKEVEDCVTNRPCGS-QVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            SD+  E+C   R C   Q RC+        RCV  R  C+ DNDCGD SDE +C
Sbjct: 3524 SDEPKEEC-DERTCEPYQFRCKN------NRCVPGRWQCDYDNDCGDNSDEESC 3570



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 17/38 (44%), Positives = 23/38 (60%), Gaps = 1/38 (2%)

Query: 125 FVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKC 162
           F C +  RC+  R LC+GDNDCG+  DE+N     + C
Sbjct: 900 FKC-ENNRCIPNRWLCDGDNDCGNSEDESNATCSARTC 936



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 21/52 (40%), Positives = 28/52 (53%), Gaps = 3/52 (5%)

Query: 104 DKEVEDCVTNRPCGSQVRCEG--FVCAQTGRCVNRRLLCNGDNDCGDQSDEA 153
           D +   C+ N       +C+   F CA + RC+  R  C+GDNDC D SDEA
Sbjct: 836 DADGVTCLANPSYVPPPQCQPGEFACANS-RCIQERWKCDGDNDCLDNSDEA 886



 Score = 40.0 bits (92), Expect = 0.006
 Identities = 28/78 (35%), Positives = 36/78 (46%), Gaps = 11/78 (14%)

Query: 92   PSQFHGEPCNFSDKEVEDCVTNRPCGS--------QVRC--EGFVCAQTGRCVNRRLLCN 141
            PSQF     N     +  C     CG         +V C    F C+ T RC+ R  +C+
Sbjct: 3415 PSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCD 3474

Query: 142  GDNDCGDQSDE-ANCRRI 158
             DNDC D SDE ANC ++
Sbjct: 3475 RDNDCVDGSDEPANCTQM 3492



 Score = 38.9 bits (89), Expect = 0.013
 Identities = 28/93 (30%), Positives = 42/93 (45%), Gaps = 7/93 (7%)

Query: 64   DCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSDKEVEDCVTNRP---CGSQV 120
            DC    +S    C   ++ R    Y   PS     P +++  + +DC        C    
Sbjct: 2678 DC--GDYSDERDCPGVKRPRCPLNYFACPSG-RCIPMSWTCDKEDDCEHGEDETHCNKFC 2734

Query: 121  RCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEA 153
                F C Q  RC++++ LC+G +DCGD SDEA
Sbjct: 2735 SEAQFEC-QNHRCISKQWLCDGSDDCGDGSDEA 2766



 Score = 38.1 bits (87), Expect = 0.023
 Identities = 20/56 (35%), Positives = 25/56 (44%), Gaps = 5/56 (8%)

Query: 98   EPCNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEA 153
            + C     E   C   + CG       F C  T  CV  R LC+GD DC D +DE+
Sbjct: 2757 DDCGDGSDEAAHC-EGKTCGPS----SFSCPGTHVCVPERWLCDGDKDCADGADES 2807



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 21/66 (31%), Positives = 34/66 (51%), Gaps = 9/66 (13%)

Query: 107  VEDCVTNRPCGSQVRCEG-FVCAQTGRCVNRRLLCNGDNDCGDQSDE-------ANCRRI 158
            ++D +T R   S  R +  F CA  G C+N  L C+G   C D+SDE         C++ 
Sbjct: 2511 LQDDLTCRAVNSSCRAQDEFECAN-GECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKT 2569

Query: 159  YKKCQH 164
            +++C +
Sbjct: 2570 FRQCSN 2575



 Score = 37.4 bits (85), Expect = 0.039
 Identities = 23/67 (34%), Positives = 33/67 (49%), Gaps = 11/67 (16%)

Query: 97   GEPCNFSDK-----EVEDCVTNRPCGSQVRCEG---FVCAQTGRCVNRRLLCNGDNDCGD 148
            G  C+ +D      + EDC    P      C+    F+C +  RC++  L CN  +DCGD
Sbjct: 3713 GRQCDGTDNCGDGTDEEDC--EPPTAHTTHCKDKKEFLC-RNQRCLSSSLRCNMFDDCGD 3769

Query: 149  QSDEANC 155
             SDE +C
Sbjct: 3770 GSDEEDC 3776



 Score = 37.0 bits (84), Expect = 0.051
 Identities = 14/29 (48%), Positives = 18/29 (62%)

Query: 127  CAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            C +T  C     +C+G NDCGD SDE +C
Sbjct: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDC 2688



 Score = 35.8 bits (81), Expect = 0.11
 Identities = 29/86 (33%), Positives = 37/86 (43%), Gaps = 8/86 (9%)

Query: 103 SDKEVEDCVTNRPCGSQVRCEG--FVCAQTGRCVNRRLLCNGDNDCGDQSDEA-NCRRIY 159
           SD+  E C    P     RC+     C  T  CV    LCNG  DC D SDE  +CR + 
Sbjct: 57  SDEAPEIC----PQSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQ 112

Query: 160 KKCQHEMDQYWGIGSLASGINLFTNS 185
             C     Q+  + +L  G   + NS
Sbjct: 113 GNCSRLGCQHHCVPTL-DGPTCYCNS 137



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 22/57 (38%), Positives = 30/57 (52%), Gaps = 6/57 (10%)

Query: 100 CNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDE-ANC 155
           C  S+ E     + R C        F CA +GRC+     C+ D+DCGD+SDE A+C
Sbjct: 920 CGNSEDESNATCSARTCPPNQ----FSCA-SGRCIPISWTCDLDDDCGDRSDESASC 971



 Score = 35.4 bits (80), Expect = 0.15
 Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 1/59 (1%)

Query: 104  DKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKC 162
            D +  D    + C  +   + F C ++G C+  R  C+ D DC D SDE  C    + C
Sbjct: 3597 DHDCADGSDEKDCTPRCDMDQFQC-KSGHCIPLRWRCDADADCMDGSDEEACGTGVRTC 3654



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 24/81 (29%), Positives = 30/81 (37%), Gaps = 15/81 (18%)

Query: 109  DCVTNRPCGSQVRCEGFVCA--------QTGRCVNRRLLCNGDNDCGDQSDEA----NCR 156
            DC  N     +  CE   C          T  C+    LC+G++DCGD SDE      C 
Sbjct: 1130 DCEDN---SDEENCESLACRPPSHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCS 1186

Query: 157  RIYKKCQHEMDQYWGIGSLAS 177
                 C H      G G + S
Sbjct: 1187 LNNGGCSHNCSVAPGEGIVCS 1207



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 19/56 (33%), Positives = 23/56 (41%), Gaps = 1/56 (1%)

Query: 100  CNFSDKEVEDCVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANC 155
            CN +D +  D     PC       G    + G C+     CN   DC D SDE NC
Sbjct: 2585 CNGAD-DCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNC 2639



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 18/70 (25%), Positives = 32/70 (45%), Gaps = 7/70 (10%)

Query: 101  NFSDKEVEDCVTNRPCGSQVRCE-GFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIY 159
            ++SD+   DC    P   + RC   +    +GRC+     C+ ++DC    DE +C +  
Sbjct: 2681 DYSDER--DC----PGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHCNKFC 2734

Query: 160  KKCQHEMDQY 169
             + Q E   +
Sbjct: 2735 SEAQFECQNH 2744



 Score = 33.1 bits (74), Expect = 0.74
 Identities = 15/44 (34%), Positives = 24/44 (54%), Gaps = 5/44 (11%)

Query: 110  CVTNRPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEA 153
            C+ N  C  +     F+C Q  +C+ +  +C+ D DC D SDE+
Sbjct: 2812 CLYNSTCDDRE----FMC-QNRQCIPKHFVCDHDRDCADGSDES 2850



 Score = 32.7 bits (73), Expect = 0.96
 Identities = 19/53 (35%), Positives = 26/53 (49%), Gaps = 4/53 (7%)

Query: 103  SDKEVEDCVTNRPCGSQVRC---EGFVCAQTGRCVNRRLLCNGDNDCGDQSDE 152
            +D +  D      CG+ VR    + F C  T  C      C+G++DCGD SDE
Sbjct: 3634 ADADCMDGSDEEACGTGVRTCPLDEFQCNNT-LCKPLAWKCDGEDDCGDNSDE 3685



 Score = 32.3 bits (72), Expect = 1.3
 Identities = 15/39 (38%), Positives = 21/39 (53%), Gaps = 1/39 (2%)

Query: 114  RPCGSQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDE 152
            R C S      FVC +  +C+     C+ ++DCGD SDE
Sbjct: 3328 RTCVSNCTASQFVC-KNDKCIPFWWKCDTEDDCGDHSDE 3365



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 12/29 (41%), Positives = 17/29 (58%)

Query: 125 FVCAQTGRCVNRRLLCNGDNDCGDQSDEA 153
           F C     C+++   C+G+ DC D SDEA
Sbjct: 32  FACRDQITCISKGWRCDGERDCPDGSDEA 60



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 9/56 (16%)

Query: 108  EDCVTNRPCGSQVRCEGFVCAQTG--RCVNRRLL------CNGDNDCGDQSDEANC 155
            +DC  N     +  C  FVC      RC N R+       C+G ++CGD +DE +C
Sbjct: 3677 DDCGDNSDENPE-ECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDC 3731


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,463,523
Number of Sequences: 37866
Number of extensions: 1144880
Number of successful extensions: 3975
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 118
Number of HSP's successfully gapped in prelim test: 53
Number of HSP's that attempted gapping in prelim test: 3028
Number of HSP's gapped (non-prelim): 844
length of query: 591
length of database: 18,247,518
effective HSP length: 108
effective length of query: 483
effective length of database: 14,157,990
effective search space: 6838309170
effective search space used: 6838309170
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.