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Search of human proteins with 4557321
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens]
(267 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens] 529 e-150
gi|71773110 apolipoprotein A-IV precursor [Homo sapiens] 107 1e-23
gi|63079709 apolipoprotein AV [Homo sapiens] 70 1e-12
gi|4557325 apolipoprotein E precursor [Homo sapiens] 59 6e-09
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 47 2e-05
gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens] 46 3e-05
gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens] 46 3e-05
gi|210032790 hypothetical protein LOC27146 [Homo sapiens] 44 1e-04
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 43 3e-04
gi|116008447 CAP-GLY domain containing linker protein 2 isoform ... 43 3e-04
gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2... 43 3e-04
gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens] 42 4e-04
gi|229577185 epidermal growth factor receptor pathway substrate ... 42 7e-04
gi|4503593 epidermal growth factor receptor pathway substrate 15... 42 7e-04
gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens] 42 7e-04
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 42 7e-04
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 42 7e-04
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 42 7e-04
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 41 0.001
gi|35038601 spindle assembly abnormal protein 6 [Homo sapiens] 41 0.001
gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens] 41 0.001
gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens] 41 0.001
gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens] 40 0.002
gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens] 40 0.002
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 40 0.002
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 40 0.002
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 40 0.002
gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens] 40 0.003
gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens] 40 0.003
gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens] 40 0.003
>gi|4557321 apolipoprotein A-I preproprotein [Homo sapiens]
Length = 267
Score = 529 bits (1362), Expect = e-150
Identities = 267/267 (100%), Positives = 267/267 (100%)
Query: 1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 60
MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS
Sbjct: 1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 60
Query: 61 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 120
ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK
Sbjct: 61 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 120
Query: 121 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 180
VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV
Sbjct: 121 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 180
Query: 181 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 240
DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ
Sbjct: 181 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 240
Query: 241 GLLPVLESFKVSFLSALEEYTKKLNTQ 267
GLLPVLESFKVSFLSALEEYTKKLNTQ
Sbjct: 241 GLLPVLESFKVSFLSALEEYTKKLNTQ 267
>gi|71773110 apolipoprotein A-IV precursor [Homo sapiens]
Length = 396
Score = 107 bits (266), Expect = 1e-23
Identities = 67/265 (25%), Positives = 130/265 (49%), Gaps = 10/265 (3%)
Query: 1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGS 60
+KA VLTLA++ + G++A D+ WD Y L ++ ++ V + S
Sbjct: 3 LKAVVLTLALVAVAGARAEV--SADQVATVMWD--------YFSQLSNNAKEAVEHLQKS 52
Query: 61 ALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAK 120
L +QLN D V + L+++L P E + L K++E L++E+ K+LEE++A+
Sbjct: 53 ELTQQLNALFQDKLGEVNTYAGDLQKKLVPFATELHERLAKDSEKLKEEIGKELEELRAR 112
Query: 121 VQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHV 180
+ P+ ++ +K + + +Q++EP +L+ + +L+ +L+P + M R +
Sbjct: 113 LLPHANEVSQKIGDNLRELQQRLEPYADQLRTQVSTQAEQLRRQLTPYAQRMERVLRENA 172
Query: 181 DALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQ 240
D+L+ L P++DEL+ ++ +E LK E+ K + + L P +D ++
Sbjct: 173 DSLQASLRPHADELKAKIDQNVEELKGRLTPYADEFKVKIDQTVEELRRSLAPYAQDTQE 232
Query: 241 GLLPVLESFKVSFLSALEEYTKKLN 265
L LE EE +++
Sbjct: 233 KLNHQLEGLTFQMKKNAEELKARIS 257
Score = 68.9 bits (167), Expect = 4e-12
Identities = 44/185 (23%), Positives = 87/185 (47%), Gaps = 15/185 (8%)
Query: 77 VTSTFSKLREQLGPVTQEF-----------WDNLEKETEGLRQEMSKDLEEVKAKVQPYL 125
V++ +LR QL P Q +L + L+ ++ +++EE+K ++ PY
Sbjct: 146 VSTQAEQLRRQLTPYAQRMERVLRENADSLQASLRPHADELKAKIDQNVEELKGRLTPYA 205
Query: 126 DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRT 185
D+F+ K + +E R+ + P + QE +L L ++ EE++ R A + LR
Sbjct: 206 DEFKVKIDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQ 265
Query: 186 HLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPV 245
LAP ++++R L E L+++ LAE + + + +P E+ + L+
Sbjct: 266 RLAPLAEDVRGNLRGNTEGLQKS----LAELGGHLDQQVEEFRRRVEPYGENFNKALVQQ 321
Query: 246 LESFK 250
+E +
Sbjct: 322 MEQLR 326
Score = 52.8 bits (125), Expect = 3e-07
Identities = 33/153 (21%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 77 VTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEM 136
+ T +LR L P Q+ + L + EGL +M K+ EE+KA++ ++ +++
Sbjct: 212 IDQTVEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKARISASAEELRQRLAPLA 271
Query: 137 ELYR-------QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAP 189
E R + ++ AEL Q++ E + ++ P GE ++ LR L P
Sbjct: 272 EDVRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGP 331
Query: 190 YSDELRQRLAARLEALKENGGARLAEYHAKATE 222
++ ++ L+ + L++ + + + K ++
Sbjct: 332 HAGDVEGHLSFLEKDLRDKVNSFFSTFKEKESQ 364
Score = 50.8 bits (120), Expect = 1e-06
Identities = 33/148 (22%), Positives = 74/148 (50%), Gaps = 9/148 (6%)
Query: 35 VKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQE 94
V++L +D+ Q EG + N + L ++++ +LR++L P+ ++
Sbjct: 216 VEELRRSLAPYAQDTQEKLNHQLEGLTFQMKKNAEELKA--RISASAEELRQRLAPLAED 273
Query: 95 FWDNLEKETEGLRQEMSK-------DLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLR 147
NL TEGL++ +++ +EE + +V+PY ++F K ++ME RQK+ P
Sbjct: 274 VRGNLRGNTEGLQKSLAELGGHLDQQVEEFRRRVEPYGENFNKALVQQMEQLRQKLGPHA 333
Query: 148 AELQEGARQKLHELQEKLSPLGEEMRDR 175
+++ +L++K++ +++
Sbjct: 334 GDVEGHLSFLEKDLRDKVNSFFSTFKEK 361
>gi|63079709 apolipoprotein AV [Homo sapiens]
Length = 366
Score = 70.5 bits (171), Expect = 1e-12
Identities = 60/270 (22%), Positives = 120/270 (44%), Gaps = 23/270 (8%)
Query: 3 AAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSAL 62
AAVLT A+ L+ A + + WD + D GR V Q +
Sbjct: 5 AAVLTWALALLSAFSAT------QARKGFWD-------YFSQTSGDKGR--VEQIHQQKM 49
Query: 63 GKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQ 122
++ L D+ + + +K E+L P++ L ++ G+R+++ ++LEEVKA++Q
Sbjct: 50 ARE-PATLKDSLEQDLNNMNKFLEKLRPLSGSEAPRLPQDPVGMRRQLQEELEEVKARLQ 108
Query: 123 PYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR-------DR 175
PY+ + + +E RQ+++P +L E ++ ELQE+L +GE+ + D
Sbjct: 109 PYMAEAHELVGWNLEGLRQQLKPYTMDLMEQVALRVQELQEQLRVVGEDTKAQLLGGVDE 168
Query: 176 ARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPAL 235
A A + L++ + ++ ++ E+L G + E H H + +
Sbjct: 169 AWALLQGLQSRVVHHTGRFKELFHPYAESLVSGIGRHVQELHRSVAPHAPASPARLSRCV 228
Query: 236 EDLRQGLLPVLESFKVSFLSALEEYTKKLN 265
+ L + L ++ L++ ++L+
Sbjct: 229 QVLSRKLTLKAKALHARIQQNLDQLREELS 258
>gi|4557325 apolipoprotein E precursor [Homo sapiens]
Length = 317
Score = 58.5 bits (140), Expect = 6e-09
Identities = 61/293 (20%), Positives = 116/293 (39%), Gaps = 26/293 (8%)
Query: 1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSP------------WDRVKDLATVYVDVLKD 48
MK L V FL G QA+ + P+ W+ Y+ ++
Sbjct: 1 MKVLWAALLVTFLAGCQAKVEQAVETEPEPELRQQTEWQSGQRWELALGRFWDYLRWVQT 60
Query: 49 SGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQ 108
+ S + ++L + + + + S+L EQL PV +E L KE + +
Sbjct: 61 LSEQVQEELLSSQVTQELRALMDETMKELKAYKSELEEQLTPVAEETRARLSKELQAAQA 120
Query: 109 EMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPL 168
+ D+E+V ++ Y + Q + E R ++ +L++ + +LQ++L+
Sbjct: 121 RLGADMEDVCGRLVQYRGEVQAMLGQSTEELRVRLASHLRKLRKRLLRDADDLQKRLAVY 180
Query: 169 GEEMRDRARAHVDALRTHLAPYSDELRQRLAA-----------RLEALKENGGARLAEYH 217
R+ A + A+R L P ++ R R A R +A E AR+ E
Sbjct: 181 QAGAREGAERGLSAIRERLGPLVEQGRVRAATVGSLAGQPLQERAQAWGERLRARMEEMG 240
Query: 218 AKATEHLSTLSE---KAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ 267
++ + L + E + + LE+ Q + E+F+ S E + + Q
Sbjct: 241 SRTRDRLDEVKEQVAEVRAKLEEQAQQIRLQAEAFQARLKSWFEPLVEDMQRQ 293
Score = 28.9 bits (63), Expect = 4.9
Identities = 15/77 (19%), Positives = 37/77 (48%), Gaps = 4/77 (5%)
Query: 56 QFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLE 115
Q A G++L ++ + +++EQ+ V + LE++ + +R +
Sbjct: 222 QERAQAWGERLRARMEEMGSRTRDRLDEVKEQVAEVRAK----LEEQAQQIRLQAEAFQA 277
Query: 116 EVKAKVQPYLDDFQKKW 132
+K+ +P ++D Q++W
Sbjct: 278 RLKSWFEPLVEDMQRQW 294
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 46.6 bits (109), Expect = 2e-05
Identities = 42/179 (23%), Positives = 84/179 (46%), Gaps = 5/179 (2%)
Query: 64 KQLNLKLLDNWDSVTSTFSKLREQ-LGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQ 122
+QL KL + + +EQ L + + +E+E +R+E S+ L ++A+VQ
Sbjct: 619 QQLREKLCQEEEEEILRLHQQKEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQ 678
Query: 123 PYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDA 182
+ + + E E QK LR EL+ + + L++K + E++++ A +
Sbjct: 679 SSTQADEDQIRAEQEASLQK---LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKS 735
Query: 183 LRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHL-STLSEKAKPALEDLRQ 240
+ L ++ Q+L +LE ++ A L + H+ E L S+L K + + L++
Sbjct: 736 EQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELERLCSSLEAKHREVVSSLQK 794
Score = 40.0 bits (92), Expect = 0.002
Identities = 69/296 (23%), Positives = 116/296 (39%), Gaps = 68/296 (22%)
Query: 16 SQARHFWQQDEPPQSP-----WDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKL 70
S R ++EPPQ P W ++L G D ++L QL+L+
Sbjct: 483 SPPRSLATEEEPPQGPEGQPEWKEAEEL-----------GED-----SAASLSLQLSLQR 526
Query: 71 LDNWDSVTSTFSKLREQ------LGPVTQEFWDNLEKET--------------------E 104
+ S + K +EQ LGP +E D EK E
Sbjct: 527 -EQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPE 585
Query: 105 GLRQEMSKDLEEVKAKV-----QPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLH 159
L + K +EE A+V + L+ Q+K Q+ E Q+ E L + Q L
Sbjct: 586 QLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQKEQSLS 645
Query: 160 ELQEKLSPLGEE----MRDRARAHVDALRTHLAPYS----DELRQRLAARLEALKENGGA 211
L+E+L EE MR+ + LR + + D++R A L+ L+E
Sbjct: 646 SLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKLRE---- 701
Query: 212 RLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ 267
E ++ ++L +K + LE L++ + +S + + +A E+ ++L Q
Sbjct: 702 ---ELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQ 754
Score = 31.6 bits (70), Expect = 0.76
Identities = 34/164 (20%), Positives = 65/164 (39%), Gaps = 11/164 (6%)
Query: 83 KLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDD----FQKKWQEEMEL 138
K R+ L + +E + + E L K L++++ +++ + +K+ E+E
Sbjct: 717 KNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGERKEAVATLEKEHSAELER 776
Query: 139 YRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRL 198
+E E+ ++K+ E Q+K ++ + V H+A Y EL L
Sbjct: 777 LCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQKCLGQVEHRVHQKSYHVAGYEHELSSLL 836
Query: 199 AAR---LEALKENGGARLAEYH----AKATEHLSTLSEKAKPAL 235
+ +E E ++ E H AKA E K + L
Sbjct: 837 REKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAEL 880
Score = 31.2 bits (69), Expect = 0.99
Identities = 49/197 (24%), Positives = 83/197 (42%), Gaps = 18/197 (9%)
Query: 82 SKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPY-----------LDDFQK 130
S LRE+ V E L+K E +Q M+K E+ +A+ + L+ Q+
Sbjct: 834 SLLREKRQEVEGEHERRLDKMKEEHQQVMAKAREQYEAEERKQRAELLGHLTGELERLQR 893
Query: 131 KWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPY 190
+ E+E RQ+ +L+ R++ +LQ+ L +D +A + L
Sbjct: 894 AHERELETVRQEQHKRLEDLRRRHREQERKLQDLELDLETRAKD-VKARLALLEVQEETA 952
Query: 191 SDELRQRL-AARLEALKENGGA---RLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVL 246
E +Q L R ALK + E K HL +++ + L++L+ L L
Sbjct: 953 RREKQQLLDVQRQVALKSEEATATHQQLEEAQKEHTHLLQSNQQLREILDELQARKLK-L 1011
Query: 247 ESFKVSFLSALEEYTKK 263
ES +V L A + +K
Sbjct: 1012 ES-QVDLLQAQSQQLQK 1027
>gi|154350244 hypothetical protein LOC79632 isoform 2 [Homo sapiens]
Length = 971
Score = 46.2 bits (108), Expect = 3e-05
Identities = 61/236 (25%), Positives = 102/236 (43%), Gaps = 41/236 (17%)
Query: 59 GSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDL---- 114
GSA G L L D+ + + + ++ L T++ N+E E E RQ+ + +
Sbjct: 447 GSAEG--LIASLQDSQERLQNELDLTKDSLKE-TKDALLNVEGELEQERQQHEETIAAMK 503
Query: 115 EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAEL------------------------ 150
EE K KV D + KW E + RQ+ LR EL
Sbjct: 504 EEEKLKVDKMAHDLEIKWTENL---RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 560
Query: 151 --QEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKEN 208
++ ++K+ +L ++S L + + + +L+ A ++ E RQRL LE L+E
Sbjct: 561 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE-RQRLTQELEELEEQ 619
Query: 209 GGAR---LAEYHAKATEHLSTLSEKAKPALED-LRQGLLPVLESFKVSFLSALEEY 260
R L E H A + + EK + ALE+ L+Q L+S K + ++E +
Sbjct: 620 HQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGF 675
Score = 31.6 bits (70), Expect = 0.76
Identities = 35/173 (20%), Positives = 70/173 (40%), Gaps = 29/173 (16%)
Query: 108 QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSP 167
+ ++K LEE++ + + ++D++ K + Y ++++ L+ Q + L +EK +
Sbjct: 108 ESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS-QLFTAESLQASKEKEAD 166
Query: 168 LGEEMRDR---ARAHVDALRTHLAPYSDELR------QRLAARLEALKEN---------- 208
L +E + + R + L+T L DE Q+L L + N
Sbjct: 167 LRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDD 226
Query: 209 ---GGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALE 258
G L H + L+ E+ + DL VL++ + L A +
Sbjct: 227 AKEGEMALLSKHKEVESELAAARERLQQQASDL------VLKASHIGMLQATQ 273
Score = 29.3 bits (64), Expect = 3.8
Identities = 34/170 (20%), Positives = 69/170 (40%), Gaps = 16/170 (9%)
Query: 64 KQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQP 123
K L +L + + SK E+L + + ++++ DLEE K +
Sbjct: 342 KNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKL 401
Query: 124 YLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR--DRARAHVD 181
L++ + + Q+E+E L+E KL+ +++ L + +R ++ +
Sbjct: 402 NLEEDKNQLQQELE-----------NLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAE 450
Query: 182 ALRTHLAPYSDELRQRLAARLEALKENGGARL---AEYHAKATEHLSTLS 228
L L + L+ L ++LKE A L E + +H T++
Sbjct: 451 GLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIA 500
Score = 28.1 bits (61), Expect = 8.4
Identities = 40/198 (20%), Positives = 88/198 (44%), Gaps = 36/198 (18%)
Query: 45 VLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETE 104
VLK S ++ + + + +++ +K L+ S S++ E+L LE+E
Sbjct: 260 VLKAS---HIGMLQATQMTQEVTIKDLE------SEKSRVNERLS--------QLEEERA 302
Query: 105 GLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEK 164
LR + EE K ++ + + + E Y ++++ L++ L+E ++ +L E
Sbjct: 303 FLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEE----EVTQLNEA 358
Query: 165 LSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHL 224
S EE+ + ++A+ +S+ +R + +++ L E H K +L
Sbjct: 359 HSKTLEELAWKHHMAIEAV------HSNAIRDKKKLQMD---------LEEQHNKDKLNL 403
Query: 225 STLSEKAKPALEDLRQGL 242
+ + LE+L++ L
Sbjct: 404 EEDKNQLQQELENLKEVL 421
>gi|154350226 hypothetical protein LOC79632 isoform 1 [Homo sapiens]
Length = 1140
Score = 46.2 bits (108), Expect = 3e-05
Identities = 61/236 (25%), Positives = 102/236 (43%), Gaps = 41/236 (17%)
Query: 59 GSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDL---- 114
GSA G L L D+ + + + ++ L T++ N+E E E RQ+ + +
Sbjct: 567 GSAEG--LIASLQDSQERLQNELDLTKDSLKE-TKDALLNVEGELEQERQQHEETIAAMK 623
Query: 115 EEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAEL------------------------ 150
EE K KV D + KW E + RQ+ LR EL
Sbjct: 624 EEEKLKVDKMAHDLEIKWTENL---RQECSKLREELRLQHEEDKKSAMSQLLQLKDREKN 680
Query: 151 --QEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKEN 208
++ ++K+ +L ++S L + + + +L+ A ++ E RQRL LE L+E
Sbjct: 681 AARDSWQKKVEDLLNQISLLKQNLEIQLSQSQTSLQQLQAQFTQE-RQRLTQELEELEEQ 739
Query: 209 GGAR---LAEYHAKATEHLSTLSEKAKPALED-LRQGLLPVLESFKVSFLSALEEY 260
R L E H A + + EK + ALE+ L+Q L+S K + ++E +
Sbjct: 740 HQQRHKSLKEAHVLAFQTMEEEKEKEQRALENHLQQKHSAELQSLKDAHRESMEGF 795
Score = 31.6 bits (70), Expect = 0.76
Identities = 35/173 (20%), Positives = 70/173 (40%), Gaps = 29/173 (16%)
Query: 108 QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSP 167
+ ++K LEE++ + + ++D++ K + Y ++++ L+ Q + L +EK +
Sbjct: 228 ESLNKMLEELRLERKKLIEDYEGKLNKAQSFYERELDTLKRS-QLFTAESLQASKEKEAD 286
Query: 168 LGEEMRDR---ARAHVDALRTHLAPYSDELR------QRLAARLEALKEN---------- 208
L +E + + R + L+T L DE Q+L L + N
Sbjct: 287 LRKEFQGQEAILRKTIGKLKTELQMVQDEAGSLLDKCQKLQTALAIAENNVQVLQKQLDD 346
Query: 209 ---GGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALE 258
G L H + L+ E+ + DL VL++ + L A +
Sbjct: 347 AKEGEMALLSKHKEVESELAAARERLQQQASDL------VLKASHIGMLQATQ 393
Score = 29.3 bits (64), Expect = 3.8
Identities = 34/170 (20%), Positives = 69/170 (40%), Gaps = 16/170 (9%)
Query: 64 KQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQP 123
K L +L + + SK E+L + + ++++ DLEE K +
Sbjct: 462 KNLQSRLEEEVTQLNEAHSKTLEELAWKHHMAIEAVHSNAIRDKKKLQMDLEEQHNKDKL 521
Query: 124 YLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR--DRARAHVD 181
L++ + + Q+E+E L+E KL+ +++ L + +R ++ +
Sbjct: 522 NLEEDKNQLQQELE-----------NLKEVLEDKLNTANQEIGHLQDMVRKSEQGLGSAE 570
Query: 182 ALRTHLAPYSDELRQRLAARLEALKENGGARL---AEYHAKATEHLSTLS 228
L L + L+ L ++LKE A L E + +H T++
Sbjct: 571 GLIASLQDSQERLQNELDLTKDSLKETKDALLNVEGELEQERQQHEETIA 620
Score = 28.1 bits (61), Expect = 8.4
Identities = 40/198 (20%), Positives = 88/198 (44%), Gaps = 36/198 (18%)
Query: 45 VLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETE 104
VLK S ++ + + + +++ +K L+ S S++ E+L LE+E
Sbjct: 380 VLKAS---HIGMLQATQMTQEVTIKDLE------SEKSRVNERLS--------QLEEERA 422
Query: 105 GLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEK 164
LR + EE K ++ + + + E Y ++++ L++ L+E ++ +L E
Sbjct: 423 FLRSKTQSLDEEQKQQILELEKKVNEAKRTQQEYYERELKNLQSRLEE----EVTQLNEA 478
Query: 165 LSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHL 224
S EE+ + ++A+ +S+ +R + +++ L E H K +L
Sbjct: 479 HSKTLEELAWKHHMAIEAV------HSNAIRDKKKLQMD---------LEEQHNKDKLNL 523
Query: 225 STLSEKAKPALEDLRQGL 242
+ + LE+L++ L
Sbjct: 524 EEDKNQLQQELENLKEVL 541
>gi|210032790 hypothetical protein LOC27146 [Homo sapiens]
Length = 1060
Score = 43.9 bits (102), Expect = 1e-04
Identities = 40/144 (27%), Positives = 62/144 (43%), Gaps = 6/144 (4%)
Query: 98 NLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQK 157
+L KE Q + +D + KAK+Q + Q+ ++ YR+ ++ L+ +L + R+K
Sbjct: 582 SLLKEKTSKIQRLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALK-QLSDLEREK 640
Query: 158 L-HELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEY 216
L ELQE +H ALR Q L A E LK+ L
Sbjct: 641 LQRELQETTQQNHAMKAQLEASHQRALRM----LEKARHQELKATEERLKKESSHSLQIQ 696
Query: 217 HAKATEHLSTLSEKAKPALEDLRQ 240
H L L EKA+ L++ R+
Sbjct: 697 HQTHRLELQALEEKARQELQEERE 720
Score = 34.3 bits (77), Expect = 0.12
Identities = 20/82 (24%), Positives = 40/82 (48%), Gaps = 1/82 (1%)
Query: 93 QEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQE 152
+E E+E E +RQ M + + + + Q D +K +Q + + +V L +L+
Sbjct: 219 EELQATYERENEAIRQAMQQSVSQALWQWQEKESDLRKNFQVQESALQAQVRKLEGDLEH 278
Query: 153 GARQKLHELQEKLSPLGEEMRD 174
R K+ +L++ L E ++D
Sbjct: 279 RGR-KISDLKKYAQKLKERIQD 299
Score = 33.9 bits (76), Expect = 0.15
Identities = 21/74 (28%), Positives = 37/74 (50%), Gaps = 11/74 (14%)
Query: 102 ETEGLRQEMSKDLEEVKAKVQ-----------PYLDDFQKKWQEEMELYRQKVEPLRAEL 150
ETE ++Q+ +DL ++K + + L+D KK E++ R VE R +L
Sbjct: 398 ETEYMKQQYEEDLRKIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKL 457
Query: 151 QEGARQKLHELQEK 164
Q +L E+++K
Sbjct: 458 QREVEAQLEEVRKK 471
Score = 31.2 bits (69), Expect = 0.99
Identities = 33/143 (23%), Positives = 60/143 (41%), Gaps = 25/143 (17%)
Query: 83 KLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQK 142
K++ Q + D L K E L ++ + +++ V++ V+ Q++ + ++E R+K
Sbjct: 412 KIKHQTEEEKKHLKDQLVKRLEDLVKKHTVEIKSVRSSVEAERKKLQREVEAQLEEVRKK 471
Query: 143 VE-----------PLRAELQEGARQ--KLHEL--QEKLSPLG--EEMRDRARAHVDALRT 185
E L +LQ + +L E Q K P G E ++ R H L T
Sbjct: 472 SEKEIKQLEEEKAALNVKLQNSLLEVLRLEEFIQQNKTRPTGAEESPQELGRQHCSILET 531
Query: 186 --------HLAPYSDELRQRLAA 200
+P +E + +LAA
Sbjct: 532 QDPCLKLDETSPRGEEYQDKLAA 554
Score = 31.2 bits (69), Expect = 0.99
Identities = 32/163 (19%), Positives = 65/163 (39%), Gaps = 8/163 (4%)
Query: 69 KLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDF 128
+L ++W S + Q+ ++ N ++ + L+Q + E+++ ++Q +
Sbjct: 593 RLEEDWQSQKAKLQAQVSQMQQALEQCTSNYREDLQALKQLSDLEREKLQRELQ---ETT 649
Query: 129 QKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEE----MRDRARAHVDALR 184
Q+ + +L LR L++ Q+L +E+L R + AL
Sbjct: 650 QQNHAMKAQLEASHQRALRM-LEKARHQELKATEERLKKESSHSLQIQHQTHRLELQALE 708
Query: 185 THLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTL 227
E R+R+ A+ L E+ L+E A + H L
Sbjct: 709 EKARQELQEERERMQAQQALLLESLRQELSEQQAACSGHQKDL 751
Score = 29.3 bits (64), Expect = 3.8
Identities = 23/86 (26%), Positives = 44/86 (51%), Gaps = 6/86 (6%)
Query: 125 LDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQE-KLSPLGEEMRDRARAHVDAL 183
L D ++ + E+E ++Q+ + LR + R+ L E Q+ + + E +R R + A+
Sbjct: 814 LQDAVRRLRAEVEQHQQEAQKLRDQ-----RRFLEETQQAQRAREVETLRQEHRKEMQAM 868
Query: 184 RTHLAPYSDELRQRLAARLEALKENG 209
+ +L+ RLAA LK++G
Sbjct: 869 VADFSSAQAQLQARLAALEAELKDSG 894
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 42.7 bits (99), Expect = 3e-04
Identities = 54/255 (21%), Positives = 109/255 (42%), Gaps = 22/255 (8%)
Query: 1 MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGR--DYVSQFE 58
++A +L L + +AR +Q+ + D + + A+ +L + R ++Q E
Sbjct: 1685 LEAEILQLQEELASSERARRHAEQERDELA--DEITNSASGKSALLDEKRRLEARIAQLE 1742
Query: 59 GSALGKQLNLKLL-DNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEV 117
+Q N++LL D + T L +L + ++++ RQ++ + +E+
Sbjct: 1743 EELEEEQSNMELLNDRFRKTTLQVDTLNAELAAER-----SAAQKSDNARQQLERQNKEL 1797
Query: 118 KAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQK------LHELQEKLSPLGEE 171
KAK+Q + K++ + K+ L +L++ A+++ + ++KL + +
Sbjct: 1798 KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ 1857
Query: 172 MRDRARAHVDALRTHLAPYSDEL----RQRLAARLEALKENGGAR-LAEYHAKATEHLST 226
+ D R H D + + + + RQ A EA + N R L ATE
Sbjct: 1858 VEDE-RRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEG 1916
Query: 227 LSEKAKPALEDLRQG 241
LS + LR+G
Sbjct: 1917 LSREVSTLKNRLRRG 1931
Score = 34.3 bits (77), Expect = 0.12
Identities = 39/158 (24%), Positives = 75/158 (47%), Gaps = 23/158 (14%)
Query: 108 QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQ---KLHELQEK 164
+E +K+L +++ K + + D +++ ++E E R EL++ R+ + +LQ++
Sbjct: 1019 EEKAKNLAKIRNKQEVMISDLEERLKKE--------EKTRQELEKAKRKLDGETTDLQDQ 1070
Query: 165 LSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLA-ARLEALKENGGARLA-EYHAKATE 222
++ L +A +D L+ LA +EL+ LA E L +N ++ E A+ E
Sbjct: 1071 IAEL--------QAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAE 1122
Query: 223 HLSTL-SEKA-KPALEDLRQGLLPVLESFKVSFLSALE 258
SEKA + E ++ L LE+ K L+
Sbjct: 1123 LQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160
Score = 32.3 bits (72), Expect = 0.44
Identities = 35/134 (26%), Positives = 63/134 (47%), Gaps = 19/134 (14%)
Query: 117 VKAKVQPYL------DDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGE 170
V KV+P L ++ Q K EE+ ++K + EL+E R+ L+EK + L E
Sbjct: 837 VFTKVKPLLQVTRQEEELQAK-DEELLKVKEKQTKVEGELEEMERKHQQLLEEK-NILAE 894
Query: 171 EMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKE--NGGARLAEYHAKATEHLSTLS 228
+++ T L ++E+R RLAA+ + L+E + E + + L
Sbjct: 895 QLQ---------AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEK 945
Query: 229 EKAKPALEDLRQGL 242
+K + ++DL + L
Sbjct: 946 KKMQAHIQDLEEQL 959
Score = 32.0 bits (71), Expect = 0.58
Identities = 41/162 (25%), Positives = 80/162 (49%), Gaps = 18/162 (11%)
Query: 84 LREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQK- 142
L E+L + E D L+ T +QE+ E+ A+++ L++ K + +++ RQ+
Sbjct: 1144 LSEELEALKTELEDTLD--TTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRH 1201
Query: 143 ---VEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLA 199
+E L +L++ R K + + K G E ++ A + + S+ R++L
Sbjct: 1202 ATALEELSEQLEQAKRFKANLEKNK---QGLETDNKELACEVKVLQQVKAESEHKRKKLD 1258
Query: 200 ARLEAL--KENGGARL-AEYHAKAT------EHLSTLSEKAK 232
A+++ L K + G RL E KA+ +++STL E+A+
Sbjct: 1259 AQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAE 1300
Score = 30.4 bits (67), Expect = 1.7
Identities = 29/117 (24%), Positives = 54/117 (46%), Gaps = 14/117 (11%)
Query: 97 DNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKK---WQEEMELYRQKVEPLRAELQ-- 151
+ E++ + LR +M +DL K V + + +K ++++E R ++E L ELQ
Sbjct: 1500 EEFERQNKQLRADM-EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQAT 1558
Query: 152 EGARQKLH--------ELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAA 200
E A+ +L + + L E+ ++ R + +R A DE +QR A
Sbjct: 1559 EDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALA 1615
>gi|116008447 CAP-GLY domain containing linker protein 2 isoform 1
[Homo sapiens]
Length = 1046
Score = 42.7 bits (99), Expect = 3e-04
Identities = 59/225 (26%), Positives = 84/225 (37%), Gaps = 38/225 (16%)
Query: 43 VDVLKDSGRDYVSQFEGSALGKQL----NLKLLDNW----DSVTSTFSKLREQLGPVTQE 94
VD L+ + Y + G Q N+ L+DNW DS+ S K E L
Sbjct: 578 VDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNS 637
Query: 95 FWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGA 154
+KE L+ M E +K + Q L + Q K E ++ ++ E LR
Sbjct: 638 GPGAQQKEIGELKAVM----EGIKMEHQLELGNLQAKHDLETAMHVKEKEALR------- 686
Query: 155 RQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELR----------------QRL 198
+KL E QE+L+ L R + R L D+ R +
Sbjct: 687 -EKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQ 745
Query: 199 AARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLL 243
A +E LKE LAE E L + K +E LR+ LL
Sbjct: 746 AQAIEFLKEQ--ISLAEKKMLDYERLQRAEAQGKQEVESLREKLL 788
>gi|14702162 CAP-GLY domain containing linker protein 2 isoform 2
[Homo sapiens]
Length = 1011
Score = 42.7 bits (99), Expect = 3e-04
Identities = 59/225 (26%), Positives = 84/225 (37%), Gaps = 38/225 (16%)
Query: 43 VDVLKDSGRDYVSQFEGSALGKQL----NLKLLDNW----DSVTSTFSKLREQLGPVTQE 94
VD L+ + Y + G Q N+ L+DNW DS+ S K E L
Sbjct: 543 VDKLRAANEKYAQEVAGLKDKVQQATSENMGLMDNWKSKLDSLASDHQKSLEDLKATLNS 602
Query: 95 FWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGA 154
+KE L+ M E +K + Q L + Q K E ++ ++ E LR
Sbjct: 603 GPGAQQKEIGELKAVM----EGIKMEHQLELGNLQAKHDLETAMHVKEKEALR------- 651
Query: 155 RQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELR----------------QRL 198
+KL E QE+L+ L R + R L D+ R +
Sbjct: 652 -EKLQEAQEELAGLQRHWRAQLEVQASQHRLELQEAQDQRRDAELRVHELEKLDVEYRGQ 710
Query: 199 AARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLL 243
A +E LKE LAE E L + K +E LR+ LL
Sbjct: 711 AQAIEFLKEQ--ISLAEKKMLDYERLQRAEAQGKQEVESLREKLL 753
>gi|4885399 structural maintenance of chromosomes 3 [Homo sapiens]
Length = 1217
Score = 42.4 bits (98), Expect = 4e-04
Identities = 46/170 (27%), Positives = 78/170 (45%), Gaps = 28/170 (16%)
Query: 98 NLEKETEGLRQEMSK----------DLEEVKAKVQPYLDDFQKKWQE-----EMELYRQK 142
+L KETEG R+++++ LEE K ++ Y +KW + E +Y Q+
Sbjct: 177 SLMKETEGKREKINELLKYIEERLHTLEEEKEELAQY-----QKWDKMRRALEYTIYNQE 231
Query: 143 VEPLRAELQE--GARQKLHELQEKLSPLGEEMRDR---ARAHVDALRTHLAPYSDELRQR 197
+ RA+L E R+ E +L ++ RD+ V L+T ++ +E Q
Sbjct: 232 LNETRAKLDELSAKRETSGEKSRQLRDAQQDARDKMEDIERQVRELKTKISAMKEEKEQL 291
Query: 198 LAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLE 247
A R E +K+ +L + L+ SE+ K L++ RQ LL +E
Sbjct: 292 SAERQEQIKQR--TKLELKAKDLQDELAGNSEQRKRLLKE-RQKLLEKIE 338
>gi|229577185 epidermal growth factor receptor pathway substrate 15
isoform B [Homo sapiens]
Length = 582
Score = 41.6 bits (96), Expect = 7e-04
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 27/124 (21%)
Query: 93 QEFWDNLEKETEGLR---------QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKV 143
Q+ D +++E L+ QE+ +L+E KA+++ L + +KK EE +L +
Sbjct: 57 QDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL----I 112
Query: 144 EPLRAEL--QEG-----------ARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPY 190
L+AEL QE AR++L LQ++ + L EE + +A ++ L+ HL
Sbjct: 113 SSLKAELTSQESQISTYEEELAKAREELSRLQQETAEL-EESVESGKAQLEPLQQHLQDS 171
Query: 191 SDEL 194
E+
Sbjct: 172 QQEI 175
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 41.6 bits (96), Expect = 7e-04
Identities = 35/124 (28%), Positives = 62/124 (50%), Gaps = 27/124 (21%)
Query: 93 QEFWDNLEKETEGLR---------QEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKV 143
Q+ D +++E L+ QE+ +L+E KA+++ L + +KK EE +L +
Sbjct: 371 QDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL----I 426
Query: 144 EPLRAEL--QEG-----------ARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPY 190
L+AEL QE AR++L LQ++ + L EE + +A ++ L+ HL
Sbjct: 427 SSLKAELTSQESQISTYEEELAKAREELSRLQQETAEL-EESVESGKAQLEPLQQHLQDS 485
Query: 191 SDEL 194
E+
Sbjct: 486 QQEI 489
>gi|48255883 troponin T type 2, cardiac isoform 4 [Homo sapiens]
Length = 282
Score = 41.6 bits (96), Expect = 7e-04
Identities = 39/136 (28%), Positives = 65/136 (47%), Gaps = 9/136 (6%)
Query: 107 RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS 166
R+ M KDL E++A ++ + ++ +KK +EE+ + ++E RAE E R + +E+ +
Sbjct: 87 RKRMEKDLNELQALIEAHFEN-RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN 145
Query: 167 PLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLST 226
L EE RAR + R DE R++ A L + GG + + T
Sbjct: 146 RLAEE---RARREEEENRRKA---EDEARKKKA--LSNMMHFGGYIQKAQTERKSGKRQT 197
Query: 227 LSEKAKPALEDLRQGL 242
EK K L + R+ L
Sbjct: 198 EREKKKKILAERRKVL 213
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 41.6 bits (96), Expect = 7e-04
Identities = 58/214 (27%), Positives = 91/214 (42%), Gaps = 45/214 (21%)
Query: 52 DYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMS 111
D +++F A ++ +K L+ KLR + + D L KE +G RQE
Sbjct: 1031 DRLAEFSSQAAEEEEKVKSLN----------KLRLKYEATIADMEDRLRKEEKG-RQE-- 1077
Query: 112 KDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAEL----------------QEGAR 155
LE++K + LD + QE+M +Q+ E LRA+L + GAR
Sbjct: 1078 --LEKLKRR----LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1131
Query: 156 -QKLHELQEKLSPLGEEMRDR-----ARAHVDALRTHLAPYSDELRQRLAARLEALKENG 209
Q L L+E + L E D AR + R L + LR L L++
Sbjct: 1132 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1191
Query: 210 GARLAEYHAKATEHLSTLSEKAK---PALEDLRQ 240
R ++ + TE TL E+ + A+++LRQ
Sbjct: 1192 ELR-SKREQEVTELKKTLEEETRIHEAAVQELRQ 1224
Score = 31.6 bits (70), Expect = 0.76
Identities = 35/127 (27%), Positives = 66/127 (51%), Gaps = 11/127 (8%)
Query: 120 KVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR-A 178
KV+P L ++ E ++ Q+++ ++ ELQ+ + +++ ELQ +++ L EE RAR A
Sbjct: 865 KVKPLLQVTRQ--DEVLQARAQELQKVQ-ELQQQSAREVGELQGRVAQLEEE---RARLA 918
Query: 179 HVDALRTHLAPYSDELRQRLAAR---LEALKENGGARLAEYHAKATEHLSTLSEKAKPAL 235
L ++E R RLAAR LE + AR+ E + + + T ++ + +
Sbjct: 919 EQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGE-EEECSRQMQTEKKRLQQHI 977
Query: 236 EDLRQGL 242
++L L
Sbjct: 978 QELEAHL 984
>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
Length = 1995
Score = 41.6 bits (96), Expect = 7e-04
Identities = 58/214 (27%), Positives = 91/214 (42%), Gaps = 45/214 (21%)
Query: 52 DYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMS 111
D +++F A ++ +K L+ KLR + + D L KE +G RQE
Sbjct: 1023 DRLAEFSSQAAEEEEKVKSLN----------KLRLKYEATIADMEDRLRKEEKG-RQE-- 1069
Query: 112 KDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAEL----------------QEGAR 155
LE++K + LD + QE+M +Q+ E LRA+L + GAR
Sbjct: 1070 --LEKLKRR----LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1123
Query: 156 -QKLHELQEKLSPLGEEMRDR-----ARAHVDALRTHLAPYSDELRQRLAARLEALKENG 209
Q L L+E + L E D AR + R L + LR L L++
Sbjct: 1124 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1183
Query: 210 GARLAEYHAKATEHLSTLSEKAK---PALEDLRQ 240
R ++ + TE TL E+ + A+++LRQ
Sbjct: 1184 ELR-SKREQEVTELKKTLEEETRIHEAAVQELRQ 1216
Score = 31.6 bits (70), Expect = 0.76
Identities = 35/127 (27%), Positives = 66/127 (51%), Gaps = 11/127 (8%)
Query: 120 KVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR-A 178
KV+P L ++ E ++ Q+++ ++ ELQ+ + +++ ELQ +++ L EE RAR A
Sbjct: 857 KVKPLLQVTRQ--DEVLQARAQELQKVQ-ELQQQSAREVGELQGRVAQLEEE---RARLA 910
Query: 179 HVDALRTHLAPYSDELRQRLAAR---LEALKENGGARLAEYHAKATEHLSTLSEKAKPAL 235
L ++E R RLAAR LE + AR+ E + + + T ++ + +
Sbjct: 911 EQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGE-EEECSRQMQTEKKRLQQHI 969
Query: 236 EDLRQGL 242
++L L
Sbjct: 970 QELEAHL 976
>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
Length = 2036
Score = 41.6 bits (96), Expect = 7e-04
Identities = 58/214 (27%), Positives = 91/214 (42%), Gaps = 45/214 (21%)
Query: 52 DYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMS 111
D +++F A ++ +K L+ KLR + + D L KE +G RQE
Sbjct: 1064 DRLAEFSSQAAEEEEKVKSLN----------KLRLKYEATIADMEDRLRKEEKG-RQE-- 1110
Query: 112 KDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAEL----------------QEGAR 155
LE++K + LD + QE+M +Q+ E LRA+L + GAR
Sbjct: 1111 --LEKLKRR----LDGESSELQEQMVEQQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1164
Query: 156 -QKLHELQEKLSPLGEEMRDR-----ARAHVDALRTHLAPYSDELRQRLAARLEALKENG 209
Q L L+E + L E D AR + R L + LR L L++
Sbjct: 1165 AQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQ 1224
Query: 210 GARLAEYHAKATEHLSTLSEKAK---PALEDLRQ 240
R ++ + TE TL E+ + A+++LRQ
Sbjct: 1225 ELR-SKREQEVTELKKTLEEETRIHEAAVQELRQ 1257
Score = 31.6 bits (70), Expect = 0.76
Identities = 35/127 (27%), Positives = 66/127 (51%), Gaps = 11/127 (8%)
Query: 120 KVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRAR-A 178
KV+P L ++ E ++ Q+++ ++ ELQ+ + +++ ELQ +++ L EE RAR A
Sbjct: 898 KVKPLLQVTRQ--DEVLQARAQELQKVQ-ELQQQSAREVGELQGRVAQLEEE---RARLA 951
Query: 179 HVDALRTHLAPYSDELRQRLAAR---LEALKENGGARLAEYHAKATEHLSTLSEKAKPAL 235
L ++E R RLAAR LE + AR+ E + + + T ++ + +
Sbjct: 952 EQLRAEAELCAEAEETRGRLAARKQELELVVSELEARVGE-EEECSRQMQTEKKRLQQHI 1010
Query: 236 EDLRQGL 242
++L L
Sbjct: 1011 QELEAHL 1017
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 41.2 bits (95), Expect = 0.001
Identities = 25/109 (22%), Positives = 57/109 (52%), Gaps = 6/109 (5%)
Query: 69 KLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDF 128
K+ + + + K++EQ ++ W+ EK E ++ ++ EE+ + + + +
Sbjct: 589 KMREQEEKMWEQEEKMQEQ----EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQ 644
Query: 129 QKKWQEEMELYRQKVEPLR--AELQEGARQKLHELQEKLSPLGEEMRDR 175
++K E+ E R++ E +R E +G +K+ E +EK+ E+MR++
Sbjct: 645 EEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQ 693
Score = 37.7 bits (86), Expect = 0.011
Identities = 32/162 (19%), Positives = 78/162 (48%), Gaps = 11/162 (6%)
Query: 17 QARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDS 76
Q W+QDE + +R+++ ++ K + E ++ ++ +
Sbjct: 505 QEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMR---EEER 561
Query: 77 VTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEM 136
+ K+RE+ + +E + ++++ E +R++ K E+ + K+Q + +K W++E
Sbjct: 562 MREREKKMREE-EEMMREQEEKMQEQEEKMREQEEKMWEQ-EEKMQ---EQEEKMWEQEE 616
Query: 137 ELYRQKVEPLRAELQE---GARQKLHELQEKLSPLGEEMRDR 175
+++ Q+ E E +E +K+ E +EK+ E+MR++
Sbjct: 617 KMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Score = 35.4 bits (80), Expect = 0.052
Identities = 32/159 (20%), Positives = 72/159 (45%), Gaps = 17/159 (10%)
Query: 17 QARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDS 76
Q W+QDE + +R+++ ++ K + + + E K+ + ++
Sbjct: 357 QEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREK---------KMREEEET 407
Query: 77 VTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEM 136
+ K+++Q + W+ EKE + R K+ + K+Q + +K W++E
Sbjct: 408 MREQEEKMQKQ----EENMWEQEEKEWQQQRLPEQKEKLWEQEKMQ---EQEEKIWEQE- 459
Query: 137 ELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDR 175
E R + E E + ++K+ E ++++ E+MRD+
Sbjct: 460 EKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQ 498
Score = 31.6 bits (70), Expect = 0.76
Identities = 35/152 (23%), Positives = 75/152 (49%), Gaps = 7/152 (4%)
Query: 83 KLREQLGPVTQEFWDNLEKETEGLRQEMSKDL--EEVKAKVQPYLDDFQKKWQEEMELYR 140
+LREQ G + +E + + ++ + LR E K+L +E + + Q L + +++ QE+ E
Sbjct: 263 RLREQEGKM-REQEEKMRRQEKRLR-EQEKELREQEKELREQKKLREQEEQMQEQEEKMW 320
Query: 141 QKVEPLRAELQEGARQ--KLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRL 198
++ E +R + ++ RQ +L E ++++ ++MRD+ + L + +R++
Sbjct: 321 EQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ-DERLREKEERMREQE 379
Query: 199 AARLEALKENGGARLAEYHAKATEHLSTLSEK 230
+ K R+ E K E T+ E+
Sbjct: 380 KMWEQEEKMQEEERIREREKKMREEEETMREQ 411
Score = 31.2 bits (69), Expect = 0.99
Identities = 19/78 (24%), Positives = 45/78 (57%), Gaps = 3/78 (3%)
Query: 102 ETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQ--KLH 159
+T L++EM + EE++ + + +K W++E E R++ +R + ++ RQ +L
Sbjct: 228 QTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQE-ERLREQEGKMREQEEKMRRQEKRLR 286
Query: 160 ELQEKLSPLGEEMRDRAR 177
E +++L +E+R++ +
Sbjct: 287 EQEKELREQEKELREQKK 304
Score = 30.8 bits (68), Expect = 1.3
Identities = 24/94 (25%), Positives = 48/94 (51%), Gaps = 15/94 (15%)
Query: 83 KLREQLGPVTQEFWDN---LEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELY 139
K+R+Q + W+ L ++ E +R++ +E K + + + + +KK +EE E
Sbjct: 353 KMRDQ----EERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408
Query: 140 RQKVEPLR--------AELQEGARQKLHELQEKL 165
R++ E ++ E +E +Q+L E +EKL
Sbjct: 409 REQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 442
Score = 28.5 bits (62), Expect = 6.4
Identities = 23/126 (18%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 69 KLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDF 128
K+ + + + K+REQ +E E++ ++M E+++ + +
Sbjct: 647 KMWEQEEKMREQEEKMREQ-----EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQE 701
Query: 129 QKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLA 188
+K W +E +++ Q E + ++++ E +E++ E+M++R H +
Sbjct: 702 EKMWGQEEKMWGQ-------EEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCL 754
Query: 189 PYSDEL 194
P S L
Sbjct: 755 PPSKVL 760
>gi|35038601 spindle assembly abnormal protein 6 [Homo sapiens]
Length = 657
Score = 41.2 bits (95), Expect = 0.001
Identities = 45/195 (23%), Positives = 83/195 (42%), Gaps = 19/195 (9%)
Query: 64 KQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQP 123
K+ L L+ + D T R+ L QE + LR E + + K
Sbjct: 161 KEEKLSLMQSLDDATKQLDFTRKTLAEKKQEL--------DKLRNEWASHTAALTNKHSQ 212
Query: 124 YLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRD------RAR 177
L + ++K + Y+Q+ E + +L+ +Q +H+LQ +LS L +D +
Sbjct: 213 ELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGD 272
Query: 178 AHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKA---KPA 234
+ + L+ L+ +EL QR + +L+ E H K +H++ L K +
Sbjct: 273 STIRELKAKLSGVEEEL-QRTKQEVLSLRRENSTLDVECHEK-EKHVNQLQTKVAVLEQE 330
Query: 235 LEDLRQGLLPVLESF 249
++D Q +L E+F
Sbjct: 331 IKDKDQLVLRTKEAF 345
>gi|48255879 troponin T type 2, cardiac isoform 2 [Homo sapiens]
Length = 288
Score = 40.8 bits (94), Expect = 0.001
Identities = 41/138 (29%), Positives = 69/138 (50%), Gaps = 12/138 (8%)
Query: 107 RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS 166
R+ M KDL E++A ++ + ++ +KK +EE+ + ++E RAE E R + +E+ +
Sbjct: 92 RKRMEKDLNELQALIEAHFEN-RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN 150
Query: 167 PLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGG--ARLAEYHAKATEHL 224
L EE RAR + R DE R++ A L + GG + A+ K+ +
Sbjct: 151 RLAEE---RARREEEENRRKA---EDEARKKKA--LSNMMHFGGYIQKQAQTERKSGKR- 201
Query: 225 STLSEKAKPALEDLRQGL 242
T EK K L + R+ L
Sbjct: 202 QTEREKKKKILAERRKVL 219
>gi|71361682 nuclear mitotic apparatus protein 1 [Homo sapiens]
Length = 2115
Score = 40.8 bits (94), Expect = 0.001
Identities = 52/211 (24%), Positives = 94/211 (44%), Gaps = 20/211 (9%)
Query: 51 RDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLE------KETE 104
R V Q S K+ LK + + +T +QL +E +L K+ E
Sbjct: 550 RHQVEQLSSSLKQKEQQLKEVA--EKQEATRQDHAQQLATAAEEREASLRERDAALKQLE 607
Query: 105 GLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRA--ELQ---EGARQKLH 159
L +E + LE ++ ++Q + + R+K E R ELQ E ARQ+ H
Sbjct: 608 ALEKEKAAKLEILQQQLQVANEARDSAQTSVTQAQREKAELSRKVEELQACVETARQEQH 667
Query: 160 ELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAK 219
E Q +++ L ++R + + + +A D+L+++L A E+LK G+ L E +
Sbjct: 668 EAQAQVAELELQLRSEQQKATE--KERVAQEKDQLQEQLQALKESLKVTKGS-LEEEKRR 724
Query: 220 ATEHLSTLSEKAKPALEDLRQGLLPVLESFK 250
A + L E+ + + +L+ ++E K
Sbjct: 725 AADAL----EEQQRCISELKAETRSLVEQHK 751
Score = 37.0 bits (84), Expect = 0.018
Identities = 59/238 (24%), Positives = 93/238 (39%), Gaps = 25/238 (10%)
Query: 47 KDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVT--QEFWDNLEKETE 104
++ GR A +L ++L + + F+ L+E L +E D +
Sbjct: 1011 QERGRAQADLALEKAARAELEMRLQNALNEQRVEFATLQEALAHALTEKEGKDQELAKLR 1070
Query: 105 GLRQEMSKDLEEVKAKVQPYLDDFQKKWQE-------------EMELYRQKVEPLRAELQ 151
GL K+LEE++ V+ + KK +E E K+E LRAE+
Sbjct: 1071 GLEAAQIKELEELRQTVKQLKEQLAKKEKEHASGSGAQSEAAGRTEPTGPKLEALRAEVS 1130
Query: 152 EGARQKLHELQEKLSPLGE--EMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENG 209
+ Q+ + QE+ L E +RA D+ L +E Q L AL +
Sbjct: 1131 K-LEQQCQKQQEQADSLERSLEAERASRAERDSALETLQGQLEEKAQELGHSQSAL-ASA 1188
Query: 210 GARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ 267
LA + K +H S ++ K + RQ K S +S+LEE LN Q
Sbjct: 1189 QRELAAFRTKVQDH-SKAEDEWKAQVARGRQE-----AERKNSLISSLEEEVSILNRQ 1240
Score = 33.1 bits (74), Expect = 0.26
Identities = 43/166 (25%), Positives = 67/166 (40%), Gaps = 34/166 (20%)
Query: 129 QKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLA 188
+K+ +EE+E +Q LRAEL R EL E L PL +++ ++ R LR A
Sbjct: 1378 EKRHREELEQSKQAAGGLRAELLRAQR----ELGE-LIPLRQKVAEQERT-AQQLRAEKA 1431
Query: 189 PYSDEL------------------------RQRLAARLEALKENGGARLAEYHAKATEHL 224
Y+++L RQ L L+ +E LA A A L
Sbjct: 1432 SYAEQLSMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQELAAVRADAETRL 1491
Query: 225 STLSEKAKPALEDLRQGLLPVLESFKVSFL---SALEEYTKKLNTQ 267
+ + +A+ +L + + E KV L +E +KL Q
Sbjct: 1492 AEVQREAQSTAREL-EVMTAKYEGAKVKVLEERQRFQEERQKLTAQ 1536
Score = 31.2 bits (69), Expect = 0.99
Identities = 54/234 (23%), Positives = 95/234 (40%), Gaps = 50/234 (21%)
Query: 80 TFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEV----KAKVQPYLDDFQKKWQEE 135
T +LR + ++ ++ K+ GL E ++ L E + ++ LD ++K+ +E
Sbjct: 1422 TAQQLRAEKASYAEQL--SMLKKAHGLLAEENRGLGERANLGRQFLEVELDQAREKYVQE 1479
Query: 136 MELYRQKVEPLRAELQEGARQKLHELQ--------EKLSPLGE-----EMRDRARAHVDA 182
+ R E AE+Q A+ EL+ K+ L E E R + A V+
Sbjct: 1480 LAAVRADAETRLAEVQREAQSTARELEVMTAKYEGAKVKVLEERQRFQEERQKLTAQVEQ 1539
Query: 183 LRTHLAPYS---DELRQRLA----------ARLEALKENGG----------ARLAEYHA- 218
L + +EL ++LA +L+A++ GG A+L E A
Sbjct: 1540 LEVFQREQTKQVEELSKKLADSDQASKVQQQKLKAVQAQGGESQQEAQRLQAQLNELQAQ 1599
Query: 219 -----KATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ 267
+A EH EKAK + +Q + E + L L++ K+L +
Sbjct: 1600 LSQKEQAAEHYKLQMEKAKTHYDAKKQQNQELQEQLR--SLEQLQKENKELRAE 1651
>gi|48255881 troponin T type 2, cardiac isoform 3 [Homo sapiens]
Length = 285
Score = 40.4 bits (93), Expect = 0.002
Identities = 42/140 (30%), Positives = 68/140 (48%), Gaps = 19/140 (13%)
Query: 107 RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS 166
R+ M KDL E++A ++ + ++ +KK +EE+ + ++E RAE E R + +E+ +
Sbjct: 92 RKRMEKDLNELQALIEAHFEN-RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN 150
Query: 167 PLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLS- 225
L EE RAR + R DE R++ A L + GG + + TE S
Sbjct: 151 RLAEE---RARREEEENRRKA---EDEARKKKA--LSNMMHFGG------YIQKTERKSG 196
Query: 226 ---TLSEKAKPALEDLRQGL 242
T EK K L + R+ L
Sbjct: 197 KRQTEREKKKKILAERRKVL 216
>gi|48255877 troponin T type 2, cardiac isoform 1 [Homo sapiens]
Length = 295
Score = 40.4 bits (93), Expect = 0.002
Identities = 42/140 (30%), Positives = 68/140 (48%), Gaps = 19/140 (13%)
Query: 107 RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS 166
R+ M KDL E++A ++ + ++ +KK +EE+ + ++E RAE E R + +E+ +
Sbjct: 102 RKRMEKDLNELQALIEAHFEN-RKKEEEELVSLKDRIERRRAERAEQQRIRNEREKERQN 160
Query: 167 PLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLS- 225
L EE RAR + R DE R++ A L + GG + + TE S
Sbjct: 161 RLAEE---RARREEEENRRKA---EDEARKKKA--LSNMMHFGG------YIQKTERKSG 206
Query: 226 ---TLSEKAKPALEDLRQGL 242
T EK K L + R+ L
Sbjct: 207 KRQTEREKKKKILAERRKVL 226
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/178 (23%), Positives = 80/178 (44%), Gaps = 26/178 (14%)
Query: 102 ETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQ-------------KVEPLRA 148
E+ G +EM KDL E A + +DD +E + R+ +E +
Sbjct: 1760 ESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKE 1819
Query: 149 ELQEGARQKLHELQEKLSPLGEEMR--DRARA---HVDALRTHLAPYSDELRQRLAARLE 203
++ G RQ + L+E L E R D + +V+ ++T L P S+EL ++ +
Sbjct: 1820 AVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQ 1879
Query: 204 ALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYT 261
+K+ +LAE ++A H + L++ + + G+L ++ + +A + Y+
Sbjct: 1880 EIKDR---KLAEKVSQAESHAAQLNDSSA-----VLDGILDEAKNISFNATAAFKAYS 1929
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 40.0 bits (92), Expect = 0.002
Identities = 41/178 (23%), Positives = 80/178 (44%), Gaps = 26/178 (14%)
Query: 102 ETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQ-------------KVEPLRA 148
E+ G +EM KDL E A + +DD +E + R+ +E +
Sbjct: 1760 ESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKE 1819
Query: 149 ELQEGARQKLHELQEKLSPLGEEMR--DRARA---HVDALRTHLAPYSDELRQRLAARLE 203
++ G RQ + L+E L E R D + +V+ ++T L P S+EL ++ +
Sbjct: 1820 AVESGKRQIENTLKEGNDILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQ 1879
Query: 204 ALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYT 261
+K+ +LAE ++A H + L++ + + G+L ++ + +A + Y+
Sbjct: 1880 EIKDR---KLAEKVSQAESHAAQLNDSSA-----VLDGILDEAKNISFNATAAFKAYS 1929
>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
sapiens]
Length = 1937
Score = 40.0 bits (92), Expect = 0.002
Identities = 52/186 (27%), Positives = 92/186 (49%), Gaps = 37/186 (19%)
Query: 72 DNWDSVTSTFSKLREQL----GPVTQEF-----WDNLEKETEG---LRQEMSKDLEEVKA 119
D + +T +KL +Q+ G + QE + +++ EG L QE + D+E K
Sbjct: 1018 DKVNILTKAKTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQ 1077
Query: 120 KVQPYLDDFQKKWQEEMELYRQKVEPLRA-ELQEGARQKLHELQEKLSPLGEEMR-DRA- 176
+ LD+ +K + E+ K+E +A E+Q ++K+ ELQ ++ LGEE+ +RA
Sbjct: 1078 Q----LDEKLEKKEFEISNLISKIEDEQAVEIQ--LQKKIKELQARIEELGEEIEAERAS 1131
Query: 177 RAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALE 236
RA + R+ L+ +E+ +R L+E GGA A+ L++K + +
Sbjct: 1132 RAKAEKQRSDLSRELEEISER-------LEEAGGATSAQVE---------LNKKREAEFQ 1175
Query: 237 DLRQGL 242
LR+ L
Sbjct: 1176 KLRRDL 1181
Score = 37.7 bits (86), Expect = 0.011
Identities = 37/144 (25%), Positives = 66/144 (45%), Gaps = 6/144 (4%)
Query: 55 SQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDL 114
SQ E +L +L K+ + ++ LR + + QE D E+ EG +Q +L
Sbjct: 1473 SQKESRSLSTEL-FKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAEGGKQ--IHEL 1529
Query: 115 EEVKAKVQPYLDDFQKKWQE-EMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMR 173
E++K +V+ + Q +E E L ++ + LR +L+ Q E+ K++ EE+
Sbjct: 1530 EKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLE--LNQVKSEVDRKIAEKDEEID 1587
Query: 174 DRARAHVDALRTHLAPYSDELRQR 197
R H + T + E+R R
Sbjct: 1588 QLKRNHTRVVETMQSTLDAEIRSR 1611
Score = 31.6 bits (70), Expect = 0.76
Identities = 41/175 (23%), Positives = 74/175 (42%), Gaps = 18/175 (10%)
Query: 99 LEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKL 158
L K+ E Q++ +DLEE + + + +KK + M ++++ L+ Q+ ++K
Sbjct: 1166 LNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEK- 1224
Query: 159 HELQEKLSPLGE--EMRDRARAHVDALRTHLAPYSDELR------QRLAARLEALKENGG 210
EL+ + L E +A+ +++ + L EL+ QRL L A +
Sbjct: 1225 SELKMETDDLSSNAEAISKAKGNLEKMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQ 1284
Query: 211 ARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLN 265
EY + E + +S+ L +Q +E K LEE TK N
Sbjct: 1285 TEAGEYSRQLDEKDALVSQ-----LSRSKQASTQQIEELK----HQLEEETKAKN 1330
>gi|112789538 troponin T3, skeletal, fast isoform 2 [Homo sapiens]
Length = 256
Score = 39.7 bits (91), Expect = 0.003
Identities = 38/139 (27%), Positives = 67/139 (48%), Gaps = 16/139 (11%)
Query: 107 RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS 166
++ +KDL E++A + + + +KK +EE+ ++++E RAE E R + + +E+ +
Sbjct: 59 KKRQNKDLMELQALIDSHFEA-RKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQN 117
Query: 167 PLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATE---H 223
L EE R DA R D+L+++ A + GA + Y AKA +
Sbjct: 118 RLAEE--KARREEEDAKRR----AEDDLKKKKAL------SSMGANYSSYLAKADQKRGK 165
Query: 224 LSTLSEKAKPALEDLRQGL 242
T E K L + R+ L
Sbjct: 166 KQTAREMKKKILAERRKPL 184
Score = 31.2 bits (69), Expect = 0.99
Identities = 46/195 (23%), Positives = 78/195 (40%), Gaps = 28/195 (14%)
Query: 86 EQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYL-------------DDFQKKW 132
E++ V +++ + E + E E+ +++ E + K +P L DD QKK
Sbjct: 4 EEVEQVEEQYEEEEEAQEEAA--EVHEEVHEPEEKPRPKLTAPKIPEGEKVDFDDIQKKR 61
Query: 133 QEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSD 192
Q + + Q + E ++ ++L L+E++ E R RA +R A
Sbjct: 62 QNKDLMELQALIDSHFEARKKEEEELVALKERI-----EKRRAERAEQQRIR---AEKER 113
Query: 193 ELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKP--ALEDLRQGLLPVLESFK 250
E + RLA +E R AE K + LS++ A D ++G K
Sbjct: 114 ERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMK 173
Query: 251 VSFLSALEEYTKKLN 265
L+ E K LN
Sbjct: 174 KKILA---ERRKPLN 185
>gi|112789536 troponin T3, skeletal, fast isoform 3 [Homo sapiens]
Length = 250
Score = 39.7 bits (91), Expect = 0.003
Identities = 38/139 (27%), Positives = 67/139 (48%), Gaps = 16/139 (11%)
Query: 107 RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS 166
++ +KDL E++A + + + +KK +EE+ ++++E RAE E R + + +E+ +
Sbjct: 53 KKRQNKDLMELQALIDSHFEA-RKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQN 111
Query: 167 PLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATE---H 223
L EE R DA R D+L+++ A + GA + Y AKA +
Sbjct: 112 RLAEE--KARREEEDAKRR----AEDDLKKKKAL------SSMGANYSSYLAKADQKRGK 159
Query: 224 LSTLSEKAKPALEDLRQGL 242
T E K L + R+ L
Sbjct: 160 KQTAREMKKKILAERRKPL 178
Score = 32.0 bits (71), Expect = 0.58
Identities = 46/187 (24%), Positives = 74/187 (39%), Gaps = 18/187 (9%)
Query: 86 EQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPY-----LDDFQKKWQEEMELYR 140
E++ V +++ + E + E QE K ++ A P DD QKK Q + +
Sbjct: 4 EEVEQVEEQYEEEEEAQEEEEVQEEEKPRPKLTAPKIPEGEKVDFDDIQKKRQNKDLMEL 63
Query: 141 QKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAA 200
Q + E ++ ++L L+E++ E R RA +R A E + RLA
Sbjct: 64 QALIDSHFEARKKEEEELVALKERI-----EKRRAERAEQQRIR---AEKERERQNRLAE 115
Query: 201 RLEALKENGGARLAEYHAKATEHLSTLSEKAKP--ALEDLRQGLLPVLESFKVSFLSALE 258
+E R AE K + LS++ A D ++G K L+
Sbjct: 116 EKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMKKKILA--- 172
Query: 259 EYTKKLN 265
E K LN
Sbjct: 173 ERRKPLN 179
>gi|5803203 troponin T3, skeletal, fast isoform 1 [Homo sapiens]
Length = 258
Score = 39.7 bits (91), Expect = 0.003
Identities = 38/139 (27%), Positives = 67/139 (48%), Gaps = 16/139 (11%)
Query: 107 RQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLS 166
++ +KDL E++A + + + +KK +EE+ ++++E RAE E R + + +E+ +
Sbjct: 61 KKRQNKDLMELQALIDSHFEA-RKKEEEELVALKERIEKRRAERAEQQRIRAEKERERQN 119
Query: 167 PLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATE---H 223
L EE R DA R D+L+++ A + GA + Y AKA +
Sbjct: 120 RLAEE--KARREEEDAKRR----AEDDLKKKKAL------SSMGANYSSYLAKADQKRGK 167
Query: 224 LSTLSEKAKPALEDLRQGL 242
T E K L + R+ L
Sbjct: 168 KQTAREMKKKILAERRKPL 186
Score = 30.8 bits (68), Expect = 1.3
Identities = 46/195 (23%), Positives = 77/195 (39%), Gaps = 26/195 (13%)
Query: 86 EQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYL-------------DDFQKKW 132
E++ V +++ + E + E QE + + + + K +P L DD QKK
Sbjct: 4 EEVEQVEEQYEEEEEAQEEEEVQEDTAEEDAEEEKPRPKLTAPKIPEGEKVDFDDIQKKR 63
Query: 133 QEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSD 192
Q + + Q + E ++ ++L L+E++ E R RA +R A
Sbjct: 64 QNKDLMELQALIDSHFEARKKEEEELVALKERI-----EKRRAERAEQQRIR---AEKER 115
Query: 193 ELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKP--ALEDLRQGLLPVLESFK 250
E + RLA +E R AE K + LS++ A D ++G K
Sbjct: 116 ERQNRLAEEKARREEEDAKRRAEDDLKKKKALSSMGANYSSYLAKADQKRGKKQTAREMK 175
Query: 251 VSFLSALEEYTKKLN 265
L+ E K LN
Sbjct: 176 KKILA---ERRKPLN 187
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,714,438
Number of Sequences: 37866
Number of extensions: 429581
Number of successful extensions: 3371
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 87
Number of HSP's successfully gapped in prelim test: 491
Number of HSP's that attempted gapping in prelim test: 2339
Number of HSP's gapped (non-prelim): 1269
length of query: 267
length of database: 18,247,518
effective HSP length: 100
effective length of query: 167
effective length of database: 14,460,918
effective search space: 2414973306
effective search space used: 2414973306
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.