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Search of human proteins with 4557241
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557241 actinin, alpha 3 [Homo sapiens]
(901 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557241 actinin, alpha 3 [Homo sapiens] 1807 0.0
gi|4501893 actinin, alpha 2 [Homo sapiens] 1481 0.0
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 1454 0.0
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 1440 0.0
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 1439 0.0
gi|12025678 actinin, alpha 4 [Homo sapiens] 1390 0.0
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 432 e-121
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 432 e-121
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 422 e-118
gi|67782321 spectrin beta isoform a [Homo sapiens] 409 e-114
gi|67782319 spectrin beta isoform b [Homo sapiens] 409 e-114
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 403 e-112
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 345 1e-94
gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 260 4e-69
gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) ... 260 4e-69
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 252 1e-66
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 249 8e-66
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 248 1e-65
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 248 1e-65
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 248 1e-65
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 248 1e-65
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 248 1e-65
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 248 1e-65
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 245 2e-64
gi|221316624 dystonin isoform 4 [Homo sapiens] 236 7e-62
gi|221316622 dystonin isoform 3 [Homo sapiens] 236 7e-62
gi|221316618 dystonin isoform 2 [Homo sapiens] 236 7e-62
gi|34577047 dystonin isoform 1 [Homo sapiens] 236 7e-62
gi|33188445 microfilament and actin filament cross-linker protei... 231 2e-60
gi|110611228 utrophin [Homo sapiens] 196 8e-50
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 1807 bits (4681), Expect = 0.0
Identities = 901/901 (100%), Positives = 901/901 (100%)
Query: 1 MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLR 60
MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLR
Sbjct: 1 MMMVMQPEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLR 60
Query: 61 KAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVK 120
KAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVK
Sbjct: 61 KAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVK 120
Query: 121 LVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNV 180
LVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNV
Sbjct: 121 LVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNV 180
Query: 181 QNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAED 240
QNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAED
Sbjct: 181 QNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAED 240
Query: 241 IVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASEL 300
IVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASEL
Sbjct: 241 IVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASEL 300
Query: 301 LEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLR 360
LEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLR
Sbjct: 301 LEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLR 360
Query: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLH 420
LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLH
Sbjct: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLH 420
Query: 421 EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDY 480
EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDY
Sbjct: 421 EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDY 480
Query: 481 HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD 540
HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD
Sbjct: 481 HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD 540
Query: 541 GAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRP 600
GAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRP
Sbjct: 541 GAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRP 600
Query: 601 CSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWI 660
CSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWI
Sbjct: 601 CSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWI 660
Query: 661 QAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHT 720
QAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHT
Sbjct: 661 QAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHT 720
Query: 721 VYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMM 780
VYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMM
Sbjct: 721 VYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMM 780
Query: 781 EPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVA 840
EPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVA
Sbjct: 781 EPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVA 840
Query: 841 SFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESD 900
SFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESD
Sbjct: 841 SFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESD 900
Query: 901 L 901
L
Sbjct: 901 L 901
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 1481 bits (3833), Expect = 0.0
Identities = 713/877 (81%), Positives = 801/877 (91%)
Query: 25 EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 84
EYM QEE+WDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE
Sbjct: 18 EYMIQEEEWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 77
Query: 85 VISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTI 144
VISGERLP+PD+GKMRFHKIANVNKALD+IASKGVKLVSIGAEEIVDGN+KMTLGMIWTI
Sbjct: 78 VISGERLPKPDRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 137
Query: 145 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDL 204
ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVN+QNFHTSWKDGL LCALIHRHRPDL
Sbjct: 138 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDL 197
Query: 205 IDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFA 264
IDY+KL KDDPIGN+N A E+AEK+LDIPKMLDAEDIVNTPKPDE+AIMTYVSCFYHAFA
Sbjct: 198 IDYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCFYHAFA 257
Query: 265 GAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQ 324
GAEQAETAANRICKVLAVNQENE+LMEEYE+LASELLEWIRRT+PWLENR E +M AMQ
Sbjct: 258 GAEQAETAANRICKVLAVNQENERLMEEYERLASELLEWIRRTIPWLENRTPEKTMQAMQ 317
Query: 325 RKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRG 384
+KLEDFRDYRR HKPP++QEKCQLEINFNTLQTKLR+S+RPAFMPSEGK+VSDIA AW+
Sbjct: 318 KKLEDFRDYRRKHKPPKVQEKCQLEINFNTLQTKLRISNRPAFMPSEGKMVSDIAGAWQR 377
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEV 444
LEQ EKGYE+WLL+EIRRL+RL+HLAEKFRQKAS HE W GKE++L Q+DY+SA L EV
Sbjct: 378 LEQAEKGYEEWLLNEIRRLERLEHLAEKFRQKASTHETWAYGKEQILLQKDYESASLTEV 437
Query: 445 RALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT 504
RALLR+HEAFESDLAAHQDRVE IAA+AQELNELDYH+A +VN RCQ ICDQWD LGTLT
Sbjct: 438 RALLRKHEAFESDLAAHQDRVEQIAAIAQELNELDYHDAVNVNDRCQKICDQWDRLGTLT 497
Query: 505 QKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTA 564
QKRR+ALERMEKLLETIDQL LEFA+RAAPFNNW++GA+EDLQD+++VHS+EE QSL+TA
Sbjct: 498 QKRREALERMEKLLETIDQLHLEFAKRAAPFNNWMEGAMEDLQDMFIVHSIEEIQSLITA 557
Query: 565 HDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKL 624
H+QFKATLPEAD ER +IM IQ E++K+ Q+Y +R S+NPY T++ ++ TKWD V++L
Sbjct: 558 HEQFKATLPEADGERQSIMAIQNEVEKVIQSYNIRISSSNPYSTVTMDELRTKWDKVKQL 617
Query: 625 VPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAG 684
VP RDQ+LQEELARQ NERLRRQFAAQANAIGPWIQ K+EE+ R + + G+LE+QM
Sbjct: 618 VPIRDQSLQEELARQHANERLRRQFAAQANAIGPWIQNKMEEIARSSIQITGALEDQMNQ 677
Query: 685 LRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINE 744
L+Q E NIINYK NID+LEGDHQL+QE+LVFDNKHT Y+MEHIRVGWE LLT+IARTINE
Sbjct: 678 LKQYEHNIINYKNNIDKLEGDHQLIQEALVFDNKHTNYTMEHIRVGWELLLTTIARTINE 737
Query: 745 VENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLGEVEFARI 804
VE Q+LTRDAKG++QEQ+NEFRASFNHFDR++NG+M+ +DFRACLISMGYDLGE EFARI
Sbjct: 738 VETQILTRDAKGITQEQMNEFRASFNHFDRRKNGLMDHEDFRACLISMGYDLGEAEFARI 797
Query: 805 MTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAK 864
MT+VDPN G VTFQ+FIDFMTRETA+TDT EQV+ASF+ILA DK YI EELRRELP
Sbjct: 798 MTLVDPNGQGTVTFQSFIDFMTRETADTDTAEQVIASFRILASDKPYILAEELRRELPPD 857
Query: 865 QAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901
QA+YCI+RM Y G G+ GALDY AFSSALYGESDL
Sbjct: 858 QAQYCIKRMPAYSGPGSVPGALDYAAFSSALYGESDL 894
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 1454 bits (3764), Expect = 0.0
Identities = 698/877 (79%), Positives = 799/877 (91%)
Query: 25 EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 84
+YM+ EEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLLE
Sbjct: 11 DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
Query: 85 VISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTI 144
VISGERL +P++GKMR HKI+NVNKALDFIASKGVKLVSIGAEEIVDGN+KMTLGMIWTI
Sbjct: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
Query: 145 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDL 204
ILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVN+QNFH SWKDGL CALIHRHRP+L
Sbjct: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
Query: 205 IDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFA 264
IDY KLRKDDP+ NLNTAF+VAEKYLDIPKMLDAEDIV T +PDEKAIMTYVS FYHAF+
Sbjct: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
Query: 265 GAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQ 324
GA++AETAANRICKVLAVNQENE+LME+YEKLAS+LLEWIRRT+PWLENRV E +M AMQ
Sbjct: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
Query: 325 RKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRG 384
+KLEDFRDYRRLHKPP++QEKCQLEINFNTLQTKLRLS+RPAFMPSEG++VSDI NAW
Sbjct: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEV 444
LEQVEKGYE+WLL+EIRRL+RL HLAEKFRQKAS+HEAWT GKE ML Q+DY++A L E+
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
Query: 445 RALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT 504
+ALL++HEAFESDLAAHQDRVE IAA+AQELNELDY+++ SVN+RCQ ICDQWDNLG LT
Sbjct: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
Query: 505 QKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTA 564
QKRR+ALER EKLLETIDQL LE+A+RAAPFNNW++GA+EDLQD ++VH++EE Q L TA
Sbjct: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
Query: 565 HDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKL 624
H+QFKATLP+AD+ER AI+GI E+ KI QTY + TNPY T++PQ+IN KWD VR+L
Sbjct: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
Query: 625 VPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAG 684
VP RDQ L EE ARQQ NERLR+QF AQAN IGPWIQ K+EE+GR++ + G+LE+Q++
Sbjct: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
Query: 685 LRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINE 744
LRQ E++I+NYK ID+LEGDHQL+QE+L+FDNKHT Y+MEHIRVGWEQLLT+IARTINE
Sbjct: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
Query: 745 VENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLGEVEFARI 804
VENQ+LTRDAKG+SQEQ+NEFRASFNHFDRK+ GMM+ DDFRACLISMGY++GE EFARI
Sbjct: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRKKTGMMDTDDFRACLISMGYNMGEAEFARI 790
Query: 805 MTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRRELPAK 864
M++VDPN GVVTFQAFIDFM+RETA+TDT +QV+ASFKILAGDKNYIT +ELRRELP
Sbjct: 791 MSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRRELPPD 850
Query: 865 QAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901
QAEYCI RM PY G + GALDY++FS+ALYGESDL
Sbjct: 851 QAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 887
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 1440 bits (3727), Expect = 0.0
Identities = 693/882 (78%), Positives = 797/882 (90%), Gaps = 5/882 (0%)
Query: 25 EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 84
+YM+ EEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLLE
Sbjct: 11 DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
Query: 85 VISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTI 144
VISGERL +P++GKMR HKI+NVNKALDFIASKGVKLVSIGAEEIVDGN+KMTLGMIWTI
Sbjct: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
Query: 145 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDL 204
ILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVN+QNFH SWKDGL CALIHRHRP+L
Sbjct: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
Query: 205 IDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFA 264
IDY KLRKDDP+ NLNTAF+VAEKYLDIPKMLDAEDIV T +PDEKAIMTYVS FYHAF+
Sbjct: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
Query: 265 GAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQ 324
GA++AETAANRICKVLAVNQENE+LME+YEKLAS+LLEWIRRT+PWLENRV E +M AMQ
Sbjct: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
Query: 325 RKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRG 384
+KLEDFRDYRRLHKPP++QEKCQLEINFNTLQTKLRLS+RPAFMPSEG++VSDI NAW
Sbjct: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEV 444
LEQVEKGYE+WLL+EIRRL+RL HLAEKFRQKAS+HEAWT GKE ML Q+DY++A L E+
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
Query: 445 RALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT 504
+ALL++HEAFESDLAAHQDRVE IAA+AQELNELDY+++ SVN+RCQ ICDQWDNLG LT
Sbjct: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
Query: 505 QKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTA 564
QKRR+ALER EKLLETIDQL LE+A+RAAPFNNW++GA+EDLQD ++VH++EE Q L TA
Sbjct: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
Query: 565 HDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKL 624
H+QFKATLP+AD+ER AI+GI E+ KI QTY + TNPY T++PQ+IN KWD VR+L
Sbjct: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
Query: 625 VPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAG 684
VP RDQ L EE ARQQ NERLR+QF AQAN IGPWIQ K+EE+GR++ + G+LE+Q++
Sbjct: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
Query: 685 LRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINE 744
LRQ E++I+NYK ID+LEGDHQL+QE+L+FDNKHT Y+MEHIRVGWEQLLT+IARTINE
Sbjct: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
Query: 745 VENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDL-----GEV 799
VENQ+LTRDAKG+SQEQ+NEFRASFNHFDR +G + P++F+ACLIS+GYD+ GE
Sbjct: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQGEA 790
Query: 800 EFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFKILAGDKNYITPEELRR 859
EFARIM++VDPN GVVTFQAFIDFM+RETA+TDT +QV+ASFKILAGDKNYIT +ELRR
Sbjct: 791 EFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQVMASFKILAGDKNYITMDELRR 850
Query: 860 ELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901
ELP QAEYCI RM PY G + GALDY++FS+ALYGESDL
Sbjct: 851 ELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYGESDL 892
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 1439 bits (3726), Expect = 0.0
Identities = 698/904 (77%), Positives = 799/904 (88%), Gaps = 27/904 (2%)
Query: 25 EYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLE 84
+YM+ EEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFR+GLKLMLLLE
Sbjct: 11 DYMQPEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLE 70
Query: 85 VISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTI 144
VISGERL +P++GKMR HKI+NVNKALDFIASKGVKLVSIGAEEIVDGN+KMTLGMIWTI
Sbjct: 71 VISGERLAKPERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTI 130
Query: 145 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDL 204
ILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVN+QNFH SWKDGL CALIHRHRP+L
Sbjct: 131 ILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPEL 190
Query: 205 IDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFA 264
IDY KLRKDDP+ NLNTAF+VAEKYLDIPKMLDAEDIV T +PDEKAIMTYVS FYHAF+
Sbjct: 191 IDYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSFYHAFS 250
Query: 265 GAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQ 324
GA++AETAANRICKVLAVNQENE+LME+YEKLAS+LLEWIRRT+PWLENRV E +M AMQ
Sbjct: 251 GAQKAETAANRICKVLAVNQENEQLMEDYEKLASDLLEWIRRTIPWLENRVPENTMHAMQ 310
Query: 325 RKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRG 384
+KLEDFRDYRRLHKPP++QEKCQLEINFNTLQTKLRLS+RPAFMPSEG++VSDI NAW
Sbjct: 311 QKLEDFRDYRRLHKPPKVQEKCQLEINFNTLQTKLRLSNRPAFMPSEGRMVSDINNAWGC 370
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEV 444
LEQVEKGYE+WLL+EIRRL+RL HLAEKFRQKAS+HEAWT GKE ML Q+DY++A L E+
Sbjct: 371 LEQVEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDGKEAMLRQKDYETATLSEI 430
Query: 445 RALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLT 504
+ALL++HEAFESDLAAHQDRVE IAA+AQELNELDY+++ SVN+RCQ ICDQWDNLG LT
Sbjct: 431 KALLKKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSPSVNARCQKICDQWDNLGALT 490
Query: 505 QKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTA 564
QKRR+ALER EKLLETIDQL LE+A+RAAPFNNW++GA+EDLQD ++VH++EE Q L TA
Sbjct: 491 QKRREALERTEKLLETIDQLYLEYAKRAAPFNNWMEGAMEDLQDTFIVHTIEEIQGLTTA 550
Query: 565 HDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKL 624
H+QFKATLP+AD+ER AI+GI E+ KI QTY + TNPY T++PQ+IN KWD VR+L
Sbjct: 551 HEQFKATLPDADKERLAILGIHNEVSKIVQTYHVNMAGTNPYTTITPQEINGKWDHVRQL 610
Query: 625 VPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAG 684
VP RDQ L EE ARQQ NERLR+QF AQAN IGPWIQ K+EE+GR++ + G+LE+Q++
Sbjct: 611 VPRRDQALTEEHARQQHNERLRKQFGAQANVIGPWIQTKMEEIGRISIEMHGTLEDQLSH 670
Query: 685 LRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINE 744
LRQ E++I+NYK ID+LEGDHQL+QE+L+FDNKHT Y+MEHIRVGWEQLLT+IARTINE
Sbjct: 671 LRQYEKSIVNYKPKIDQLEGDHQLIQEALIFDNKHTNYTMEHIRVGWEQLLTTIARTINE 730
Query: 745 VENQVLTRDAKGLSQEQLNEFRASFNHFDR---------------------------KRN 777
VENQ+LTRDAKG+SQEQ+NEFRASFNHFDR K+
Sbjct: 731 VENQILTRDAKGISQEQMNEFRASFNHFDRDHSGTLGPEEFKACLISLGYDIGNDPQKKT 790
Query: 778 GMMEPDDFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQ 837
GMM+ DDFRACLISMGY++GE EFARIM++VDPN GVVTFQAFIDFM+RETA+TDT +Q
Sbjct: 791 GMMDTDDFRACLISMGYNMGEAEFARIMSIVDPNRLGVVTFQAFIDFMSRETADTDTADQ 850
Query: 838 VVASFKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYG 897
V+ASFKILAGDKNYIT +ELRRELP QAEYCI RM PY G + GALDY++FS+ALYG
Sbjct: 851 VMASFKILAGDKNYITMDELRRELPPDQAEYCIARMAPYTGPDSVPGALDYMSFSTALYG 910
Query: 898 ESDL 901
ESDL
Sbjct: 911 ESDL 914
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 1390 bits (3597), Expect = 0.0
Identities = 666/900 (74%), Positives = 790/900 (87%), Gaps = 8/900 (0%)
Query: 7 PEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQI 66
P G G G GGG G+YM QE+DWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQI
Sbjct: 15 PSSAGNGAG---GGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQI 71
Query: 67 ENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGA 126
ENI+EDFR+GLKLMLLLEVISGERLP+P++GKMR HKI NVNKALDFIASKGVKLVSIGA
Sbjct: 72 ENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGA 131
Query: 127 EEIVDGNLKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTS 186
EEIVDGN KMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPY+NVNVQNFH S
Sbjct: 132 EEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHIS 191
Query: 187 WKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPK 246
WKDGLA ALIHRHRP+LI+Y KLRKDDP+ NLN AFEVAEKYLDIPKMLDAEDIVNT +
Sbjct: 192 WKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTAR 251
Query: 247 PDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRR 306
PDEKAIMTYVS FYHAF+GA++AETAANRICKVLAVNQENE LME+YEKLAS+LLEWIRR
Sbjct: 252 PDEKAIMTYVSSFYHAFSGAQKAETAANRICKVLAVNQENEHLMEDYEKLASDLLEWIRR 311
Query: 307 TVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPA 366
T+PWLE+RV + ++ MQ+KLEDFRDYRR+HKPP++QEKCQLEINFNTLQTKLRLS+RPA
Sbjct: 312 TIPWLEDRVPQKTIQEMQQKLEDFRDYRRVHKPPKVQEKCQLEINFNTLQTKLRLSNRPA 371
Query: 367 FMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRG 426
FMPSEGK+VSDI N W+ LEQ EKGYE+WLL+EIRRL+RL HLAEKFRQKAS+HEAWT G
Sbjct: 372 FMPSEGKMVSDINNGWQHLEQAEKGYEEWLLNEIRRLERLDHLAEKFRQKASIHEAWTDG 431
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
KE ML RDY++A L +++AL+R+HEAFESDLAAHQDRVE IAA+AQELNELDY+++ +V
Sbjct: 432 KEAMLKHRDYETATLSDIKALIRKHEAFESDLAAHQDRVEQIAAIAQELNELDYYDSHNV 491
Query: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDL 546
N+RCQ ICDQWD LG+LT RR+ALE+ EK LE IDQL LE+A+RAAPFNNW++ A+EDL
Sbjct: 492 NTRCQKICDQWDALGSLTHSRREALEKTEKQLEAIDQLHLEYAKRAAPFNNWMESAMEDL 551
Query: 547 QDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606
QD+++VH++EE + L++AHDQFK+TLP+ADRER AI+ I E Q+I ++ ++ +NPY
Sbjct: 552 QDMFIVHTIEEIEGLISAHDQFKSTLPDADREREAILAIHKEAQRIAESNHIKLSGSNPY 611
Query: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
T++PQ IN+KW+ V++LVP RD L EE ++QQ NE LRRQFA+QAN +GPWIQ K+EE
Sbjct: 612 TTVTPQIINSKWEKVQQLVPKRDHALLEEQSKQQSNEHLRRQFASQANVVGPWIQTKMEE 671
Query: 667 VGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEH 726
+GR++ + G+LE+Q++ L+Q E++I++YK N+D LE HQL+QE+L+FDNKHT Y+MEH
Sbjct: 672 IGRISIEMNGTLEDQLSHLKQYERSIVDYKPNLDLLEQQHQLIQEALIFDNKHTNYTMEH 731
Query: 727 IRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFR 786
IRVGWEQLLT+IARTINEVENQ+LTRDAKG+SQEQ+ EFRASFNHFD+ G + P++F+
Sbjct: 732 IRVGWEQLLTTIARTINEVENQILTRDAKGISQEQMQEFRASFNHFDKDHGGALGPEEFK 791
Query: 787 ACLISMGYDL-----GEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVAS 841
ACLIS+GYD+ GE EF RIM++VDPN +G+VTFQAFIDFM+RET +TDT +QV+AS
Sbjct: 792 ACLISLGYDVENDRQGEAEFNRIMSLVDPNHSGLVTFQAFIDFMSRETTDTDTADQVIAS 851
Query: 842 FKILAGDKNYITPEELRRELPAKQAEYCIRRMVPYKGSGAPAGALDYVAFSSALYGESDL 901
FK+LAGDKN+IT EELRRELP QAEYCI RM PY+G A GALDY +FS+ALYGESDL
Sbjct: 852 FKVLAGDKNFITAEELRRELPPDQAEYCIARMAPYQGPDAVPGALDYKSFSTALYGESDL 911
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 432 bits (1111), Expect = e-121
Identities = 260/630 (41%), Positives = 372/630 (59%), Gaps = 35/630 (5%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
E Q+KTFT W NSHL + +I ++ D R+G L+ LLEV+SGERLP+P KG+MR H
Sbjct: 40 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 99
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVE------E 157
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 100 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 159
Query: 158 TSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217
SAK+ LLLWCQ KTA Y NVN+ NF TSW+DG+A ALIH+HRPDLID+ KL+K +
Sbjct: 160 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 219
Query: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277
NL AF +AE++L + K+LD EDI + PDEK+I+TYV +YH F+ + RI
Sbjct: 220 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 278
Query: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
KVL E EK++E+YE LAS+LLEWI +T+ L NR S+ +Q++L+ F YR +
Sbjct: 279 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 338
Query: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397
KPP+ EK LE+ T+Q+K+R +++ +MP EGKL+SDI AW LE+ E E L
Sbjct: 339 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 398
Query: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESD 457
+E+ R ++L+ LA +F +KA++ E W + ++SQ ++ L V A ++HEA E+D
Sbjct: 399 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFD-LPAVEAATKKHEAIETD 457
Query: 458 LAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKL 517
+AA+++RV+ + A+A+EL +YH+ + +R + W+ L L + RR LE M
Sbjct: 458 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE-MNLG 516
Query: 518 LETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQF-KATLPEAD 576
L+ I Q L +W+D + LV S + + LL D K TL EAD
Sbjct: 517 LQKIFQEMLYIM-------DWMD------EMKVLVLSQDYGKHLLGVEDLLQKHTLVEAD 563
Query: 577 --RERGAIMGIQGEIQKIC-QTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQ 633
+ + G+ QK G +PC PQ I + + Q
Sbjct: 564 IGIQAERVRGVNASAQKFATDGEGYKPC--------DPQVIRDRVAHMEFCYQELCQLAA 615
Query: 634 EELARQQVNERLRRQFAAQANAIGPWIQAK 663
E AR + + RL + F A G WI+ K
Sbjct: 616 ERRARLEESRRLWKFFWEMAEEEG-WIREK 644
Score = 60.8 bits (146), Expect = 5e-09
Identities = 64/262 (24%), Positives = 109/262 (41%), Gaps = 26/262 (9%)
Query: 402 RLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
RL+ + L + F + A E W R KE++LS DY L +R LL +H AFE +++
Sbjct: 620 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGKDLTSVMR-LLSKHRAFEDEMSGR 677
Query: 462 QDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETI 521
E +++ ++ + + R I +QW NL L+ R+ LE
Sbjct: 678 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 730
Query: 522 DQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
L +F A + W+ ++ + + H TQSL+ H K E R
Sbjct: 731 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 786
Query: 582 IMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQV 641
+ + + + Q + + +P + I ++ V +L R Q LQ+ LA
Sbjct: 787 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 837
Query: 642 NERLRRQFAAQANAIGPWIQAK 663
L + F ++A+A WI K
Sbjct: 838 ---LYKMF-SEADACELWIDEK 855
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 386 EQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVR 445
E ++K + W RL +F + AS+ EAW G+E LS R+ ++ EV
Sbjct: 1988 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSV-DEVE 2040
Query: 446 ALLRRHEAFESDLAAHQDRVEHIAAL 471
L++RHEAFE A +R + L
Sbjct: 2041 KLIKRHEAFEKSAATWDERFSALERL 2066
Score = 43.5 bits (101), Expect = 9e-04
Identities = 65/351 (18%), Positives = 132/351 (37%), Gaps = 30/351 (8%)
Query: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLH 420
L + + +P E D+ G+E+ K + + LQ L + F + A
Sbjct: 790 LHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE-ADAC 848
Query: 421 EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDY 480
E W KE+ L+ L +++ + R E+ E ++ RV + +A++L +
Sbjct: 849 ELWIDEKEQWLNNMQIPEKL-EDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGH 907
Query: 481 HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD 540
+ ++ + +W L +++DAL + L +I LE +W+
Sbjct: 908 PSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSAL--SIQNYHLE----CNETKSWI- 958
Query: 541 GAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRP 600
+ ++ S ++ + L + L +R+ AI ++QK +
Sbjct: 959 -----REKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEH 1013
Query: 601 CSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWI 660
I +I+ W+ ++ + +R+ +L E Q QF + W+
Sbjct: 1014 PDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ--------QFLRDLDDFQSWL 1065
Query: 661 QAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQE 711
+ + + +L E L Q E N K ID E D+Q +++
Sbjct: 1066 SRTQTAIA--SEDMPNTLTEAEKLLTQHE----NIKNEIDNYEEDYQKMRD 1110
Score = 40.0 bits (92), Expect = 0.010
Identities = 50/219 (22%), Positives = 89/219 (40%), Gaps = 35/219 (15%)
Query: 373 KLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEA--WT----RG 426
K +++ AW+ L E RR+ RL +KFR + + + W R
Sbjct: 1871 KRENEVLEAWKSLLDA---------CESRRV-RLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1920
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
E RD S V L+ H+ ++++ A D L + L ++ + +
Sbjct: 1921 IEAQEKPRDVSS-----VELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEI 1975
Query: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE---FARRAAPFNNWLDGAV 543
+ L LT+KR++ +++ E E + +L LE F+R A+ WL G
Sbjct: 1976 KEK----------LLQLTEKRKEMIDKWEDRWEWL-RLILEVHQFSRDASVAEAWLLGQE 2024
Query: 544 EDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAI 582
L + SV+E + L+ H+ F+ + D A+
Sbjct: 2025 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2063
Score = 35.8 bits (81), Expect = 0.18
Identities = 30/138 (21%), Positives = 57/138 (41%), Gaps = 12/138 (8%)
Query: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
+KF Q W E+ML+ +D + + + +H+AF ++LA++++ ++ I
Sbjct: 1265 QKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1322
Query: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE-FA 529
+L A V + + W+ L + TQ + L D + E F
Sbjct: 1323 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL---------FDANKAELFT 1373
Query: 530 RRAAPFNNWLDGAVEDLQ 547
+ A + WL G +Q
Sbjct: 1374 QSCADLDKWLHGLESQIQ 1391
Score = 34.7 bits (78), Expect = 0.41
Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 410 AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIA 469
AE F Q + + W G E + DY L V LL++ + E+ + + +E +
Sbjct: 1369 AELFTQSCADLDKWLHGLESQIQSDDYGKD-LTSVNILLKKQQMLENQMEVRKKEIEELQ 1427
Query: 470 ALAQELNE 477
+ AQ L++
Sbjct: 1428 SQAQALSQ 1435
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 432 bits (1111), Expect = e-121
Identities = 260/630 (41%), Positives = 372/630 (59%), Gaps = 35/630 (5%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
E Q+KTFT W NSHL + +I ++ D R+G L+ LLEV+SGERLP+P KG+MR H
Sbjct: 53 EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMRIHC 112
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVE------E 157
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG+IWTIILRF IQDISVE +
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDNKEK 172
Query: 158 TSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217
SAK+ LLLWCQ KTA Y NVN+ NF TSW+DG+A ALIH+HRPDLID+ KL+K +
Sbjct: 173 KSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHY 232
Query: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277
NL AF +AE++L + K+LD EDI + PDEK+I+TYV +YH F+ + RI
Sbjct: 233 NLQNAFNLAEQHLGLTKLLDPEDI-SVDHPDEKSIITYVVTYYHYFSKMKALAVEGKRIG 291
Query: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
KVL E EK++E+YE LAS+LLEWI +T+ L NR S+ +Q++L+ F YR +
Sbjct: 292 KVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRTVE 351
Query: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397
KPP+ EK LE+ T+Q+K+R +++ +MP EGKL+SDI AW LE+ E E L
Sbjct: 352 KPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELALR 411
Query: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESD 457
+E+ R ++L+ LA +F +KA++ E W + ++SQ ++ L V A ++HEA E+D
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFD-LPAVEAATKKHEAIETD 470
Query: 458 LAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKL 517
+AA+++RV+ + A+A+EL +YH+ + +R + W+ L L + RR LE M
Sbjct: 471 IAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLE-MNLG 529
Query: 518 LETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQF-KATLPEAD 576
L+ I Q L +W+D + LV S + + LL D K TL EAD
Sbjct: 530 LQKIFQEMLYIM-------DWMD------EMKVLVLSQDYGKHLLGVEDLLQKHTLVEAD 576
Query: 577 --RERGAIMGIQGEIQKIC-QTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQ 633
+ + G+ QK G +PC PQ I + + Q
Sbjct: 577 IGIQAERVRGVNASAQKFATDGEGYKPC--------DPQVIRDRVAHMEFCYQELCQLAA 628
Query: 634 EELARQQVNERLRRQFAAQANAIGPWIQAK 663
E AR + + RL + F A G WI+ K
Sbjct: 629 ERRARLEESRRLWKFFWEMAEEEG-WIREK 657
Score = 60.8 bits (146), Expect = 5e-09
Identities = 64/262 (24%), Positives = 109/262 (41%), Gaps = 26/262 (9%)
Query: 402 RLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
RL+ + L + F + A E W R KE++LS DY L +R LL +H AFE +++
Sbjct: 633 RLEESRRLWKFFWEMAE-EEGWIREKEKILSSDDYGKDLTSVMR-LLSKHRAFEDEMSGR 690
Query: 462 QDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETI 521
E +++ ++ + + R I +QW NL L+ R+ LE
Sbjct: 691 SGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEA------- 743
Query: 522 DQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
L +F A + W+ ++ + + H TQSL+ H K E R
Sbjct: 744 -SLLHQFQADADDIDAWMLDILKIVSSSDVGHDEYSTQSLVKKH---KDVAEEIANYRPT 799
Query: 582 IMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQV 641
+ + + + Q + + +P + I ++ V +L R Q LQ+ LA
Sbjct: 800 LDTLHEQASALPQEH-----AESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLA---- 850
Query: 642 NERLRRQFAAQANAIGPWIQAK 663
L + F ++A+A WI K
Sbjct: 851 ---LYKMF-SEADACELWIDEK 868
Score = 43.9 bits (102), Expect = 7e-04
Identities = 28/86 (32%), Positives = 42/86 (48%), Gaps = 7/86 (8%)
Query: 386 EQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVR 445
E ++K + W RL +F + AS+ EAW G+E LS R+ ++ EV
Sbjct: 2001 EMIDKWEDRW------EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSV-DEVE 2053
Query: 446 ALLRRHEAFESDLAAHQDRVEHIAAL 471
L++RHEAFE A +R + L
Sbjct: 2054 KLIKRHEAFEKSAATWDERFSALERL 2079
Score = 43.5 bits (101), Expect = 9e-04
Identities = 65/351 (18%), Positives = 132/351 (37%), Gaps = 30/351 (8%)
Query: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLH 420
L + + +P E D+ G+E+ K + + LQ L + F + A
Sbjct: 803 LHEQASALPQEHAESPDVRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSE-ADAC 861
Query: 421 EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDY 480
E W KE+ L+ L +++ + R E+ E ++ RV + +A++L +
Sbjct: 862 ELWIDEKEQWLNNMQIPEKL-EDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGH 920
Query: 481 HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD 540
+ ++ + +W L +++DAL + L +I LE +W+
Sbjct: 921 PSEKEIKAQQDKLNTRWSQFRELVDRKKDAL--LSAL--SIQNYHLE----CNETKSWI- 971
Query: 541 GAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRP 600
+ ++ S ++ + L + L +R+ AI ++QK +
Sbjct: 972 -----REKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEH 1026
Query: 601 CSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWI 660
I +I+ W+ ++ + +R+ +L E Q QF + W+
Sbjct: 1027 PDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQ--------QFLRDLDDFQSWL 1078
Query: 661 QAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQE 711
+ + + +L E L Q E N K ID E D+Q +++
Sbjct: 1079 SRTQTAIA--SEDMPNTLTEAEKLLTQHE----NIKNEIDNYEEDYQKMRD 1123
Score = 40.0 bits (92), Expect = 0.010
Identities = 50/219 (22%), Positives = 89/219 (40%), Gaps = 35/219 (15%)
Query: 373 KLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEA--WT----RG 426
K +++ AW+ L E RR+ RL +KFR + + + W R
Sbjct: 1884 KRENEVLEAWKSLLDA---------CESRRV-RLVDTGDKFRFFSMVRDLMLWMEDVIRQ 1933
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
E RD S V L+ H+ ++++ A D L + L ++ + +
Sbjct: 1934 IEAQEKPRDVSS-----VELLMNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEI 1988
Query: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE---FARRAAPFNNWLDGAV 543
+ L LT+KR++ +++ E E + +L LE F+R A+ WL G
Sbjct: 1989 KEK----------LLQLTEKRKEMIDKWEDRWEWL-RLILEVHQFSRDASVAEAWLLGQE 2037
Query: 544 EDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAI 582
L + SV+E + L+ H+ F+ + D A+
Sbjct: 2038 PYLSSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSAL 2076
Score = 35.8 bits (81), Expect = 0.18
Identities = 30/138 (21%), Positives = 57/138 (41%), Gaps = 12/138 (8%)
Query: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
+KF Q W E+ML+ +D + + + +H+AF ++LA++++ ++ I
Sbjct: 1278 QKFLQDCQELSLWIN--EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEK 1335
Query: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE-FA 529
+L A V + + W+ L + TQ + L D + E F
Sbjct: 1336 EGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRL---------FDANKAELFT 1386
Query: 530 RRAAPFNNWLDGAVEDLQ 547
+ A + WL G +Q
Sbjct: 1387 QSCADLDKWLHGLESQIQ 1404
Score = 34.7 bits (78), Expect = 0.41
Identities = 18/68 (26%), Positives = 32/68 (47%), Gaps = 1/68 (1%)
Query: 410 AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIA 469
AE F Q + + W G E + DY L V LL++ + E+ + + +E +
Sbjct: 1382 AELFTQSCADLDKWLHGLESQIQSDDYGKD-LTSVNILLKKQQMLENQMEVRKKEIEELQ 1440
Query: 470 ALAQELNE 477
+ AQ L++
Sbjct: 1441 SQAQALSQ 1448
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 422 bits (1086), Expect = e-118
Identities = 252/652 (38%), Positives = 368/652 (56%), Gaps = 43/652 (6%)
Query: 30 EEDWDRDLLLDPAWEKQ------------QRKTFTAWCNSHLRKAGTQIENIEEDFRNGL 77
+ DWD D +E+ Q+KTFT W NSHL + ++ ++ D R+G
Sbjct: 30 DSDWDNDSSSARLFERSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGR 89
Query: 78 KLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMT 137
L+ LLEV+SGE LP+P KG+MR H + NV+KAL F+ + V L ++G+ +IVDGN ++T
Sbjct: 90 NLLRLLEVLSGEILPKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLT 149
Query: 138 LGMIWTIILRFAIQDISVE------ETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGL 191
LG++WTIILRF IQDISVE + SAK+ LLLWCQ KTA Y NVNV NF TSW+DGL
Sbjct: 150 LGLVWTIILRFQIQDISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGL 209
Query: 192 ALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKA 251
A A++H+HRPDL+D+ L+K + NL AF +AEK L + K+LD ED VN +PDEK+
Sbjct: 210 AFNAIVHKHRPDLLDFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPED-VNVDQPDEKS 268
Query: 252 IMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWL 311
I+TYV+ +YH F+ + RI KVL E E+L+E+YE LASELL+WI +T+ L
Sbjct: 269 IITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTL 328
Query: 312 ENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSE 371
+R S+S +Q +L+ F YR + KPP+ EK LE+ T+Q+KLR +++ + P E
Sbjct: 329 NDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPRE 388
Query: 372 GKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML 431
G+L+SDI AW LE+ E E L +E+ R ++L+ LA +F +KA++ E W + ++
Sbjct: 389 GRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLV 448
Query: 432 SQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQ 491
SQ ++ L V A +R+HEA E+D+ A+ RV+ + A+A EL YH+ + +R
Sbjct: 449 SQDNF-GLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
Query: 492 AICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWL 551
+ WD L + RR+ L +L + L +W++ LQ L
Sbjct: 508 NVARLWDFLRQMVAARRERLLLNLELQKVFQDLLY--------LMDWMEEMKGRLQSQDL 559
Query: 552 VHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSP 611
+ + LL H+ L EAD + +Q E + LR C NP P
Sbjct: 560 GRHLAGVEDLLQLHE-----LVEAD------IAVQAERVRAVSASALRFC--NPGKEYRP 606
Query: 612 QDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRR--QFAAQANAIGPWIQ 661
D + V KL S + + AR+ E RR +F + W++
Sbjct: 607 CDPQLVSERVAKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVR 658
Score = 58.2 bits (139), Expect = 3e-08
Identities = 82/401 (20%), Positives = 150/401 (37%), Gaps = 46/401 (11%)
Query: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
+++A +E L E +K+ +LL + W+E G + R L D +LH
Sbjct: 518 QMVAARRERLLLNLELQKVFQDLLY----LMDWMEEMKGRLQSQDLGRHLAGVEDLLQLH 573
Query: 338 KPPRIQEKCQLEINFNTLQTKLRLSHR-PAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
+ Q E + LR + + P + +LVS+ + ++E+ YE
Sbjct: 574 ELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSE------RVAKLEQSYEALC 627
Query: 397 LSEIRRLQRLQHLAE--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAF 454
R RL+ +F + EAW R ++ +L+ D L +R LL +H A
Sbjct: 628 ELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR-LLNKHTAL 686
Query: 455 ESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERM 514
+++ ++ Q+L + A+ ++R + QW+ L L ++R L +
Sbjct: 687 RGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQA 746
Query: 515 EKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH----DQFKA 570
L +F A WL A+ + L H TQ+L H ++ ++
Sbjct: 747 ASL--------YQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
P D R + + + + G P Y L + R +
Sbjct: 799 HRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQAR------------AGERAR 846
Query: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLA 671
L+ LA + ++A A G W++ K + + LA
Sbjct: 847 ALEAALALYTM--------LSEAGACGLWVEEKEQWLNGLA 879
Score = 46.6 bits (109), Expect = 1e-04
Identities = 88/416 (21%), Positives = 160/416 (38%), Gaps = 84/416 (20%)
Query: 339 PPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLS 398
P R+++ ++ F TL+ ++ + ++ V+DIA EQ+ K
Sbjct: 881 PERLEDLEVVQQRFETLEPEMNT------LAAQITAVNDIA------EQLLKANPPGKDR 928
Query: 399 EIRRLQRLQHLAEKFRQ-----KASLH---------------EAWTRGKEEMLSQRDYDS 438
+ ++L H ++FR+ KA+L +AW R K +++
Sbjct: 929 IVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKTKVIESTQGLG 988
Query: 439 ALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWD 498
L V AL R+ E DL A RV + A L +A ++N+R + + W+
Sbjct: 989 NDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQAVAINARLREVQTGWE 1048
Query: 499 NLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEET 558
+L ++R ++L +L +F R F WL T
Sbjct: 1049 DLRATMRRREESLGEARRL--------QDFLRSLDDFQAWLG----------------RT 1084
Query: 559 QSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQD----- 613
Q+ + A ++ ATLPEA+ ++GE+++ Y R + +T D
Sbjct: 1085 QTAV-ASEEGPATLPEAEALLAQHAALRGEVERAQSEYS-RLRALGEEVTRDQADPQCLF 1142
Query: 614 -------INTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
+ T W+ + ++ SR Q LA+ + R A QA + +E
Sbjct: 1143 LRQRLEALGTGWEELGRMWESR----QGRLAQAHGFQGFLRD-ARQAEGV-----LSSQE 1192
Query: 667 VGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR----LEGDHQLLQESLVFDNK 718
+ G+L+ A +++ E + N +R LE QL+ E + +K
Sbjct: 1193 YVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADK 1248
Score = 45.1 bits (105), Expect = 3e-04
Identities = 51/254 (20%), Positives = 101/254 (39%), Gaps = 15/254 (5%)
Query: 488 SRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQ 547
S+ +A+ + +G + +A E+L+E + L E + W++ + L
Sbjct: 281 SKMKALAVEGKRIGKVLDHAMEA----ERLVEKYESLASELLQ-------WIEQTIVTLN 329
Query: 548 DVWLVHSVEETQSLLTAHDQFKAT-LPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606
D L +S+ Q+ L + + ++ P E+G + + IQ + + +
Sbjct: 330 DRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREG 389
Query: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
+S DIN W+ + K R+ L+ EL RQ+ E+L +F +A W+
Sbjct: 390 RLIS--DINKAWERLEKAEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRL 447
Query: 667 VGRLAAGL-AGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSME 725
V + GL ++E + E +I+ Y + ++ L D K
Sbjct: 448 VSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHDIKRIAARQH 507
Query: 726 HIRVGWEQLLTSIA 739
++ W+ L +A
Sbjct: 508 NVARLWDFLRQMVA 521
Score = 41.2 bits (95), Expect = 0.004
Identities = 42/176 (23%), Positives = 77/176 (43%), Gaps = 20/176 (11%)
Query: 370 SEGKLVSD-IANAWRGLEQVEKGYED---WLLSEIRRLQRLQHLAEKFRQKASLHEAWTR 425
SEG + +D I +E+ K +D L +R + QH + HE
Sbjct: 1240 SEGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQ------DCHELKLW 1293
Query: 426 GKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAAS 485
E+ML+ +D + + ++H+AF ++LAA++D ++ + +EL A
Sbjct: 1294 IDEKMLTAQDVSYDEARNLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKAL 1353
Query: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE-FARRAAPFNNWLD 540
V+ + + + +WD L T TQ + +L D + E FA+ +WL+
Sbjct: 1354 VSEKLRDLHRRWDELETTTQAKARSL---------FDANRAELFAQSCCALESWLE 1400
Score = 39.3 bits (90), Expect = 0.017
Identities = 47/182 (25%), Positives = 73/182 (40%), Gaps = 20/182 (10%)
Query: 410 AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIA 469
AE F Q E+W + L DY L V LL++ + E ++A + VE I
Sbjct: 1385 AELFAQSCCALESWLESLQAQLHSDDYGKD-LTSVNILLKKQQMLEWEMAVREKEVEAIQ 1443
Query: 470 ALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFA 529
A A+ L + D A V +A+ +++ L Q R+ R++ E Q +F
Sbjct: 1444 AQAKALAQED-QGAGEVERTSRAVEEKF---RALCQPMRERCRRLQASRE-----QHQFH 1494
Query: 530 RRAAPFNNWLDGAV---------EDLQDVWLVHSVEET-QSLLTAHDQFKATLPEADRER 579
R W+ + +DL V L+ +T Q + H+ A L E R
Sbjct: 1495 RDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRAL 1554
Query: 580 GA 581
GA
Sbjct: 1555 GA 1556
Score = 39.3 bits (90), Expect = 0.017
Identities = 46/207 (22%), Positives = 85/207 (41%), Gaps = 35/207 (16%)
Query: 372 GKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML 431
G+ + +A AW L+ S R Q L +KFR ++ E E L
Sbjct: 1879 GRHMQAVAEAWAQLQG----------SSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNL 1928
Query: 432 SQ------RDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAAS 485
RD SA L +++ + ++++ A DR + +EL ++ A
Sbjct: 1929 QMDAQERPRDVSSADL-----VIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEE 1983
Query: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE---FARRAAPFNNWLDGA 542
++ + L L +R++ E+ ++ ++ + QL LE F R A WL
Sbjct: 1984 ISEK----------LSQLQARRQETAEKWQEKMDWL-QLVLEVLVFGRDAGMAEAWLCSQ 2032
Query: 543 VEDLQDVWLVHSVEETQSLLTAHDQFK 569
++ L +V+E +SL+ H+ F+
Sbjct: 2033 EPLVRSAELGCTVDEVESLIKRHEAFQ 2059
Score = 36.2 bits (82), Expect = 0.14
Identities = 29/100 (29%), Positives = 46/100 (46%), Gaps = 14/100 (14%)
Query: 383 RGLEQVEKGYE--DWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSAL 440
R E EK E DWL + L F + A + EAW +E ++ +
Sbjct: 1994 RRQETAEKWQEKMDWLQLVLEVLV--------FGRDAGMAEAWLCSQEPLVRSAEL-GCT 2044
Query: 441 LQEVRALLRRHEAFESDLAAHQDR---VEHIAALAQELNE 477
+ EV +L++RHEAF+ A ++R +E + AL + E
Sbjct: 2045 VDEVESLIKRHEAFQKSAVAWEERFCALEKLTALEEREKE 2084
Score = 34.7 bits (78), Expect = 0.41
Identities = 34/140 (24%), Positives = 57/140 (40%), Gaps = 12/140 (8%)
Query: 405 RLQHLAEKFRQKASLH---EAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
R Q LA + + LH +A R + + D L AL RRH A+E D+ A
Sbjct: 1793 RGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRHCAYEHDIQAL 1852
Query: 462 QDRVEHIAALAQELNE-LDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLET 520
+V+ + L + +A + QA+ + W Q + + R + LL+T
Sbjct: 1853 SPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAW------AQLQGSSAARRQLLLDT 1906
Query: 521 IDQLQLEFARRAAPFNNWLD 540
D+ + F + W+D
Sbjct: 1907 TDKFR--FFKAVRELMLWMD 1924
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 409 bits (1052), Expect = e-114
Identities = 248/638 (38%), Positives = 358/638 (56%), Gaps = 32/638 (5%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
E Q+KTFT W NSHL + +I ++ +D R+G L+ LLEV+SGE LP+P KGKMR H
Sbjct: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV------EE 157
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
Query: 158 TSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217
SAK+ LLLWCQ KTA Y +VNV NF +SWKDGLA ALIH+HRPDLID+ KL+ +
Sbjct: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
Query: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277
NL AF VAE+ L I +LD ED+ T PDEK+I+TYV FYH F+ + R+
Sbjct: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
Query: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
KV+ E EK++E+Y LAS+LL WI +T+ L +R S++ +Q++L+ F YR +
Sbjct: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
Query: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397
KPP+ QEK LE+ T+Q+++R +++ + P +GKLVSDI AW LE+ E E L
Sbjct: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
Query: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRD--YDSALLQEVRALLRRHEAFE 455
+E+ R ++L+ LA +F +KA++ E W + +++Q + YD L V A ++HEA E
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYD---LAAVEAAKKKHEAIE 468
Query: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERME 515
+D AA+++RV + LAQEL + +YH+ + +R I W L L Q RR LE
Sbjct: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
Query: 516 KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEA 575
L + + +W+D L + E + LL H L EA
Sbjct: 529 ALQKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKH-----KLMEA 575
Query: 576 DRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEE 635
D + IQG+ K L+ Y PQ I + + +
Sbjct: 576 D------IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
Query: 636 LARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAG 673
A+ + ++RL + F + + WI+ K + L G
Sbjct: 630 KAQLEQSKRLWK-FFWEMDEAESWIKEKEQIYSSLDYG 666
Score = 54.7 bits (130), Expect = 4e-07
Identities = 66/303 (21%), Positives = 130/303 (42%), Gaps = 34/303 (11%)
Query: 423 WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHE 482
W K +++ L + A+ R+ E D+AA Q RV+ + +Q+L + +
Sbjct: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
Query: 483 AASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGA 542
+ R + + + W L + +L+ E LL + QLQ F + F WL
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
Query: 543 VEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCS 602
+ + + S+ E + LL H K E D + + ++ +K+ Q
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIK---DEIDGHQDSYQRVKESGEKVIQG------Q 1131
Query: 603 TNP-YITLSP--QDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPW 659
T+P Y+ L + ++T W+ + ++ SR TL + L Q+ + ++ A +N +
Sbjct: 1132 TDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ--EY 1189
Query: 660 IQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR----LEGDHQLLQESLVF 715
A +E SLE AG+R+ E + + + N D+ ++ ++L+ E ++
Sbjct: 1190 TLAHLEP--------PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLY 1241
Query: 716 DNK 718
+K
Sbjct: 1242 SDK 1244
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/338 (20%), Positives = 126/338 (37%), Gaps = 21/338 (6%)
Query: 299 ELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTK 358
+L + + ++ W++ + + L + D + HK Q +
Sbjct: 532 KLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAAT 591
Query: 359 LRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKAS 418
L+ + + P + +++ D + LEQ + + +L++ + L KF +
Sbjct: 592 LKFTEGKGYQPCDPQVIQDRISH---LEQCFEELSNMAAGRKAQLEQSKRLW-KFFWEMD 647
Query: 419 LHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNEL 478
E+W + KE++ S DY L V L R+H+AFE +L +E I A +
Sbjct: 648 EAESWIKEKEQIYSSLDYGKDLTS-VLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVAR 706
Query: 479 DYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNW 538
+ +R + + QWD L L + L+ E +F A W
Sbjct: 707 KQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF--------FQFQGDADDLKAW 758
Query: 539 LDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGL 598
L A L + T++L H F L E + RG + ++ + Q + +
Sbjct: 759 LQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESRGVMEHLEQQAQGFPEEF-- 813
Query: 599 RPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEEL 636
+P +T Q + + V R Q LQE L
Sbjct: 814 ---RDSPDVTHRLQALRELYQQVVAQADLRQQRLQEAL 848
Score = 49.3 bits (116), Expect = 2e-05
Identities = 79/338 (23%), Positives = 137/338 (40%), Gaps = 45/338 (13%)
Query: 412 KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAAL 471
+F+ A +AW + +LS D RAL ++H+ F +L + +EH+
Sbjct: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDE-GATRALGKKHKDFLEELEESRGVMEHLEQQ 805
Query: 472 AQELNELDYHEAASVNSRCQAICDQWDNL---GTLTQKR-RDALERMEKLLETIDQLQLE 527
AQ E ++ ++ V R QA+ + + + L Q+R ++AL+ ET D +L
Sbjct: 806 AQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELW 863
Query: 528 FARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQG 587
+ WL A ++ D + +E Q DQ TL I G+
Sbjct: 864 MGEK----EKWL--AEMEMPDT--LEDLEVVQHRFDILDQEMKTLMTQ------IDGVNL 909
Query: 588 EIQKICQTYGLRPCSTNPYITLSPQD-INTKWDMVRKLVPSRDQTLQEELARQQVNERLR 646
+ ++ R Y QD +NT+W + LV R R+ V+ LR
Sbjct: 910 AANSLVESGHPRSREVKQY-----QDHLNTRWQAFQTLVSER---------REAVDSALR 955
Query: 647 -RQFAAQANAIGPWIQAK---VEEVGRLAAGLAG--SLEEQMAGLRQQEQNIINYKTNID 700
+ WI K VE L LAG +++ +++GL E+++ + +D
Sbjct: 956 VHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGL---ERDVAAIQARVD 1012
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSI 738
LE + Q L +S + +H+ W+ L S+
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 12/142 (8%)
Query: 372 GKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML 431
G+ + W+GL+Q +G ED LL E+ +LQ F Q +AW ++ +
Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQED-LLGEVSQLQ-------AFLQDLDDFQAWLSITQKAV 1084
Query: 432 SQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL--NELDYHEAASVNSR 489
+ D + L E LL++H + ++ HQD + + +++ + D E + R
Sbjct: 1085 ASEDMPES-LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTD-PEYLLLGQR 1142
Query: 490 CQAICDQWDNLGTLTQKRRDAL 511
+ + W+ LG + + R L
Sbjct: 1143 LEGLDTGWNALGRMWESRSHTL 1164
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/139 (24%), Positives = 62/139 (44%), Gaps = 9/139 (6%)
Query: 388 VEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEA--WTRGKEEMLSQRDYDSALLQEVR 445
+EK + D L RR ++L+ K + L + W + + DY + L Q V+
Sbjct: 1456 IEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNL-QTVQ 1514
Query: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNL----- 500
+++++ ++++ H RVE + Q+L E + + R + WD L
Sbjct: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAA 1574
Query: 501 GTLTQKRRDALERMEKLLE 519
G L Q+ RDA E + L+
Sbjct: 1575 GRL-QRLRDANEAQQYYLD 1592
Score = 40.0 bits (92), Expect = 0.010
Identities = 24/65 (36%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 402 RLQRLQHLAE--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLA 459
R +RL+ L E +F + AS+ EAW +E L+ D+ + V L++RHEAFE A
Sbjct: 2001 RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTV-DSVEKLIKRHEAFEKSTA 2059
Query: 460 AHQDR 464
+ +R
Sbjct: 2060 SWAER 2064
Score = 38.1 bits (87), Expect = 0.037
Identities = 33/135 (24%), Positives = 58/135 (42%), Gaps = 11/135 (8%)
Query: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
+ F Q W K YD A + + +H+AF ++LA+H+ +E+I A
Sbjct: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEA--RNLHNKWLKHQAFVAELASHEGWLENIDA 1334
Query: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
++L + A V+ + +A+ WD L T+++ L L+L+
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
Query: 531 RAAPFNNWLDGAVED 545
A N W+ A+ED
Sbjct: 1387 THADLNKWI-SAMED 1400
Score = 35.0 bits (79), Expect = 0.31
Identities = 27/146 (18%), Positives = 62/146 (42%), Gaps = 6/146 (4%)
Query: 369 PSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQ--KASLHEAWTRG 426
P E + D+ + + L ++ Y+ + R QRLQ + + + E W
Sbjct: 810 PEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
KE+ L++ + L +++ + R + + ++ +++ + A L E + + V
Sbjct: 867 KEKWLAEMEMPDTL-EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREV 925
Query: 487 NSRCQAICDQWDNLGTLTQKRRDALE 512
+ +W TL +RR+A++
Sbjct: 926 KQYQDHLNTRWQAFQTLVSERREAVD 951
Score = 35.0 bits (79), Expect = 0.31
Identities = 35/133 (26%), Positives = 59/133 (44%), Gaps = 14/133 (10%)
Query: 387 QVEKGY---EDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQ----RDYDSA 439
QV+K Y +D R+L+ + HL + R+ L E W KE + S +D+D
Sbjct: 1667 QVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL-EQWISEKELVASSPEMGQDFDHV 1725
Query: 440 LLQEVRALLRRHEAFESDLAA-HQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWD 498
L L + F + A Q+RV+++ A + L + + EAA++ + + W
Sbjct: 1726 TL-----LRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780
Query: 499 NLGTLTQKRRDAL 511
+L L R L
Sbjct: 1781 DLLELIDTRMQLL 1793
>gi|67782319 spectrin beta isoform b [Homo sapiens]
Length = 2137
Score = 409 bits (1052), Expect = e-114
Identities = 248/638 (38%), Positives = 358/638 (56%), Gaps = 32/638 (5%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
E Q+KTFT W NSHL + +I ++ +D R+G L+ LLEV+SGE LP+P KGKMR H
Sbjct: 53 EVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMRIHC 112
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV------EE 157
+ NV+KAL F+ + V L ++G+ +IVDGN ++ LG+IWTIILRF IQDI V E
Sbjct: 113 LENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEGRET 172
Query: 158 TSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217
SAK+ LLLWCQ KTA Y +VNV NF +SWKDGLA ALIH+HRPDLID+ KL+ +
Sbjct: 173 RSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSNARH 232
Query: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277
NL AF VAE+ L I +LD ED+ T PDEK+I+TYV FYH F+ + R+
Sbjct: 233 NLEHAFNVAERQLGIIPLLDPEDVF-TENPDEKSIITYVVAFYHYFSKMKVLAVEGKRVG 291
Query: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
KV+ E EK++E+Y LAS+LL WI +T+ L +R S++ +Q++L+ F YR +
Sbjct: 292 KVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRTVE 351
Query: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397
KPP+ QEK LE+ T+Q+++R +++ + P +GKLVSDI AW LE+ E E L
Sbjct: 352 KPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELALR 411
Query: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRD--YDSALLQEVRALLRRHEAFE 455
+E+ R ++L+ LA +F +KA++ E W + +++Q + YD L V A ++HEA E
Sbjct: 412 NELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYD---LAAVEAAKKKHEAIE 468
Query: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERME 515
+D AA+++RV + LAQEL + +YH+ + +R I W L L Q RR LE
Sbjct: 469 TDTAAYEERVRALEDLAQELEKENYHDQKRITARKDNILRLWSYLQELLQSRRQRLETTL 528
Query: 516 KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEA 575
L + + +W+D L + E + LL H L EA
Sbjct: 529 ALQKLFQDMLHSI--------DWMDEIKAHLLSAEFGKHLLEVEDLLQKH-----KLMEA 575
Query: 576 DRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEE 635
D + IQG+ K L+ Y PQ I + + +
Sbjct: 576 D------IAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGR 629
Query: 636 LARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAG 673
A+ + ++RL + F + + WI+ K + L G
Sbjct: 630 KAQLEQSKRLWK-FFWEMDEAESWIKEKEQIYSSLDYG 666
Score = 54.7 bits (130), Expect = 4e-07
Identities = 66/303 (21%), Positives = 130/303 (42%), Gaps = 34/303 (11%)
Query: 423 WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHE 482
W K +++ L + A+ R+ E D+AA Q RV+ + +Q+L + +
Sbjct: 969 WITDKTKVVESTKDLGRDLAGIIAIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQ 1028
Query: 483 AASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGA 542
+ R + + + W L + +L+ E LL + QLQ F + F WL
Sbjct: 1029 KEDIGQRQKHLEELWQGL-------QQSLQGQEDLLGEVSQLQ-AFLQDLDDFQAWLSIT 1080
Query: 543 VEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCS 602
+ + + S+ E + LL H K E D + + ++ +K+ Q
Sbjct: 1081 QKAVASEDMPESLPEAEQLLQQHAGIK---DEIDGHQDSYQRVKESGEKVIQG------Q 1131
Query: 603 TNP-YITLSP--QDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPW 659
T+P Y+ L + ++T W+ + ++ SR TL + L Q+ + ++ A +N +
Sbjct: 1132 TDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQ--EY 1189
Query: 660 IQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR----LEGDHQLLQESLVF 715
A +E SLE AG+R+ E + + + N D+ ++ ++L+ E ++
Sbjct: 1190 TLAHLEP--------PDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVAEGNLY 1241
Query: 716 DNK 718
+K
Sbjct: 1242 SDK 1244
Score = 52.8 bits (125), Expect = 1e-06
Identities = 69/338 (20%), Positives = 126/338 (37%), Gaps = 21/338 (6%)
Query: 299 ELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTK 358
+L + + ++ W++ + + L + D + HK Q +
Sbjct: 532 KLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKLMEADIAIQGDKVKAITAAT 591
Query: 359 LRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKAS 418
L+ + + P + +++ D + LEQ + + +L++ + L KF +
Sbjct: 592 LKFTEGKGYQPCDPQVIQDRISH---LEQCFEELSNMAAGRKAQLEQSKRLW-KFFWEMD 647
Query: 419 LHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNEL 478
E+W + KE++ S DY L V L R+H+AFE +L +E I A +
Sbjct: 648 EAESWIKEKEQIYSSLDYGKDLTS-VLILQRKHKAFEDELRGLDAHLEQIFQEAHGMVAR 706
Query: 479 DYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNW 538
+ +R + + QWD L L + L+ E +F A W
Sbjct: 707 KQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENF--------FQFQGDADDLKAW 758
Query: 539 LDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGL 598
L A L + T++L H F L E + RG + ++ + Q + +
Sbjct: 759 LQDAHRLLSGEDVGQDEGATRALGKKHKDF---LEELEESRGVMEHLEQQAQGFPEEF-- 813
Query: 599 RPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEEL 636
+P +T Q + + V R Q LQE L
Sbjct: 814 ---RDSPDVTHRLQALRELYQQVVAQADLRQQRLQEAL 848
Score = 49.3 bits (116), Expect = 2e-05
Identities = 79/338 (23%), Positives = 137/338 (40%), Gaps = 45/338 (13%)
Query: 412 KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAAL 471
+F+ A +AW + +LS D RAL ++H+ F +L + +EH+
Sbjct: 747 QFQGDADDLKAWLQDAHRLLSGEDVGQDE-GATRALGKKHKDFLEELEESRGVMEHLEQQ 805
Query: 472 AQELNELDYHEAASVNSRCQAICDQWDNL---GTLTQKR-RDALERMEKLLETIDQLQLE 527
AQ E ++ ++ V R QA+ + + + L Q+R ++AL+ ET D +L
Sbjct: 806 AQGFPE-EFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGET-DACELW 863
Query: 528 FARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQG 587
+ WL A ++ D + +E Q DQ TL I G+
Sbjct: 864 MGEK----EKWL--AEMEMPDT--LEDLEVVQHRFDILDQEMKTLMTQ------IDGVNL 909
Query: 588 EIQKICQTYGLRPCSTNPYITLSPQD-INTKWDMVRKLVPSRDQTLQEELARQQVNERLR 646
+ ++ R Y QD +NT+W + LV R R+ V+ LR
Sbjct: 910 AANSLVESGHPRSREVKQY-----QDHLNTRWQAFQTLVSER---------REAVDSALR 955
Query: 647 -RQFAAQANAIGPWIQAK---VEEVGRLAAGLAG--SLEEQMAGLRQQEQNIINYKTNID 700
+ WI K VE L LAG +++ +++GL E+++ + +D
Sbjct: 956 VHNYCVDCEETSKWITDKTKVVESTKDLGRDLAGIIAIQRKLSGL---ERDVAAIQARVD 1012
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSI 738
LE + Q L +S + +H+ W+ L S+
Sbjct: 1013 ALERESQQLMDSHPEQKEDIGQRQKHLEELWQGLQQSL 1050
Score = 45.4 bits (106), Expect = 2e-04
Identities = 34/142 (23%), Positives = 64/142 (45%), Gaps = 12/142 (8%)
Query: 372 GKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML 431
G+ + W+GL+Q +G ED LL E+ +LQ F Q +AW ++ +
Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQED-LLGEVSQLQ-------AFLQDLDDFQAWLSITQKAV 1084
Query: 432 SQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL--NELDYHEAASVNSR 489
+ D + L E LL++H + ++ HQD + + +++ + D E + R
Sbjct: 1085 ASEDMPES-LPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTD-PEYLLLGQR 1142
Query: 490 CQAICDQWDNLGTLTQKRRDAL 511
+ + W+ LG + + R L
Sbjct: 1143 LEGLDTGWNALGRMWESRSHTL 1164
Score = 42.4 bits (98), Expect = 0.002
Identities = 34/139 (24%), Positives = 62/139 (44%), Gaps = 9/139 (6%)
Query: 388 VEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEA--WTRGKEEMLSQRDYDSALLQEVR 445
+EK + D L RR ++L+ K + L + W + + DY + L Q V+
Sbjct: 1456 IEKRFLDLLEPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNL-QTVQ 1514
Query: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNL----- 500
+++++ ++++ H RVE + Q+L E + + R + WD L
Sbjct: 1515 LFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAA 1574
Query: 501 GTLTQKRRDALERMEKLLE 519
G L Q+ RDA E + L+
Sbjct: 1575 GRL-QRLRDANEAQQYYLD 1592
Score = 40.0 bits (92), Expect = 0.010
Identities = 24/65 (36%), Positives = 37/65 (56%), Gaps = 3/65 (4%)
Query: 402 RLQRLQHLAE--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLA 459
R +RL+ L E +F + AS+ EAW +E L+ D+ + V L++RHEAFE A
Sbjct: 2001 RWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTV-DSVEKLIKRHEAFEKSTA 2059
Query: 460 AHQDR 464
+ +R
Sbjct: 2060 SWAER 2064
Score = 38.1 bits (87), Expect = 0.037
Identities = 33/135 (24%), Positives = 58/135 (42%), Gaps = 11/135 (8%)
Query: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
+ F Q W K YD A + + +H+AF ++LA+H+ +E+I A
Sbjct: 1277 QNFLQNCQELTLWINDKLLTSQDVSYDEA--RNLHNKWLKHQAFVAELASHEGWLENIDA 1334
Query: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
++L + A V+ + +A+ WD L T+++ L L+L+
Sbjct: 1335 EGKQLMDEKPQFTALVSQKLEALHRLWDELQATTKEKTQHLSAARS-----SDLRLQ--- 1386
Query: 531 RAAPFNNWLDGAVED 545
A N W+ A+ED
Sbjct: 1387 THADLNKWI-SAMED 1400
Score = 35.0 bits (79), Expect = 0.31
Identities = 27/146 (18%), Positives = 62/146 (42%), Gaps = 6/146 (4%)
Query: 369 PSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQ--KASLHEAWTRG 426
P E + D+ + + L ++ Y+ + R QRLQ + + + E W
Sbjct: 810 PEEFRDSPDVTHRLQALREL---YQQVVAQADLRQQRLQEALDLYTVFGETDACELWMGE 866
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
KE+ L++ + L +++ + R + + ++ +++ + A L E + + V
Sbjct: 867 KEKWLAEMEMPDTL-EDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSREV 925
Query: 487 NSRCQAICDQWDNLGTLTQKRRDALE 512
+ +W TL +RR+A++
Sbjct: 926 KQYQDHLNTRWQAFQTLVSERREAVD 951
Score = 35.0 bits (79), Expect = 0.31
Identities = 35/133 (26%), Positives = 59/133 (44%), Gaps = 14/133 (10%)
Query: 387 QVEKGY---EDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQ----RDYDSA 439
QV+K Y +D R+L+ + HL + R+ L E W KE + S +D+D
Sbjct: 1667 QVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL-EQWISEKELVASSPEMGQDFDHV 1725
Query: 440 LLQEVRALLRRHEAFESDLAA-HQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWD 498
L L + F + A Q+RV+++ A + L + + EAA++ + + W
Sbjct: 1726 TL-----LRDKFRDFARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWA 1780
Query: 499 NLGTLTQKRRDAL 511
+L L R L
Sbjct: 1781 DLLELIDTRMQLL 1793
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
[Homo sapiens]
Length = 2564
Score = 403 bits (1036), Expect = e-112
Identities = 258/685 (37%), Positives = 376/685 (54%), Gaps = 40/685 (5%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
E Q+KTFT W NSHL + G I ++ D R+G L LLEV+SGE+LPRP +G+MR H
Sbjct: 60 EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMRIHS 119
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVE-----ET 158
+ NV+KAL F+ + V L ++G+ +IVDGN ++TLG++WTIILRF IQ I +E ET
Sbjct: 120 LENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDNRET 179
Query: 159 -SAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIG 217
SAK+ LLLWCQ KTA Y VN+QNF TSW+DGLA ALIHRHRPDL+D++KL K +
Sbjct: 180 RSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSNANY 239
Query: 218 NLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRIC 277
NL AF AE++L + ++LD ED VN PDEK+I+TYV FYH F+ + RI
Sbjct: 240 NLQRAFRTAEQHLGLARLLDPED-VNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKRIG 298
Query: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
KVL E K++E YE+LA+ELL WI RTV + N+ S+S +Q++L+ F Y L
Sbjct: 299 KVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCTLE 358
Query: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLL 397
KP + QEK LE+ ++Q+KLR +R F+P EG + DI AW LE+ E E L
Sbjct: 359 KPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAALR 418
Query: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESD 457
+E+ R ++L+ LA++F K ++ E+W + ++SQ ++ L V A +++HEA E+D
Sbjct: 419 AELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYE-LPAVEAAMKKHEAIEAD 477
Query: 458 LAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKL 517
+AA+++RV+ +A LAQ L Y++ V ++ ++ QW L L RR LE+ L
Sbjct: 478 IAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLVGARRTRLEQNLAL 537
Query: 518 LETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADR 577
+ ++ +W++ L + E LL H + + A
Sbjct: 538 QKVFQEM--------VYMVDWMEEMQAQLLSRECGQHLVEADDLLQKHGLLEGDI-AAQS 588
Query: 578 ERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
ER + + + Q G +PC PQ I + + V + LQE+ A
Sbjct: 589 ER--VEALNAAALRFSQLQGYQPC--------DPQVICNRVNHVHGCLAE----LQEQAA 634
Query: 638 RQQVNERLRRQFAA---QANAIGPWIQAKVEEV----GRLAAGLAGSLEEQMAG--LRQQ 688
R++ R A + W + K + G AAG AG+ L
Sbjct: 635 RRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694
Query: 689 EQNIINYKTNIDRLEGDHQLLQESL 713
+ + +K L G LLQ++L
Sbjct: 695 ARLLAQHKILQGELGGRRALLQQAL 719
Score = 52.0 bits (123), Expect = 2e-06
Identities = 93/493 (18%), Positives = 191/493 (38%), Gaps = 72/493 (14%)
Query: 267 EQAETAANRICKVLAVNQENEKLM---EEYEKLASEL---LEWIRRTVPWLENRVGEPSM 320
E+ R+ ++L QE +L+ +E ++A +L L W++ +P +
Sbjct: 1488 ERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGL 1547
Query: 321 SAMQRKLEDFRDYRRLHKP--PRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDI 378
A+Q+ ++ + RR + PR++E + R + E + V
Sbjct: 1548 QAVQQHIKKNQGLRREIQAHGPRLEEVLE------------RAGALASLRSPEAEAVR-- 1593
Query: 379 ANAWRGLEQVEKGYEDWLLSEIRRLQRLQHL--AEKFRQKASLHEAWTRGKEEMLSQRDY 436
RGLEQ++ + + RR Q L E++ + EAW G++E+L +
Sbjct: 1594 ----RGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWL-GEQELLMMSED 1648
Query: 437 DSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQ 496
Q LL++H E + +++ + ++ + L E+ + ++ ++ R +
Sbjct: 1649 KGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708
Query: 497 WDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVE 556
+ L L ++RR ALE+ L + +R+ + +W+ L E
Sbjct: 1709 YVALKELGEERRVALEQQYWL--------YQLSRQVSELEHWIAEKEVVAGSPELGQDFE 1760
Query: 557 ETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLS--PQDI 614
L +F + A RER + + + ++ + C T++ +
Sbjct: 1761 HVSVLQEKFSEFASETGMAGRER--LAAVNQMVDELIE------CGHTAAATMAEWKDGL 1812
Query: 615 NTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGL 674
N W + +L+ +R Q L R +F + A + I+ K + RL
Sbjct: 1813 NEAWAELLELMGTRAQLL--------AASRELHKFFSDARELQGQIEEKRRRLPRLT--- 1861
Query: 675 AGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEH-------- 726
+ E ++ + ++ ++ L + LQE TVY+ EH
Sbjct: 1862 --TPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAA--QLRTVYAGEHAEAIASRE 1917
Query: 727 --IRVGWEQLLTS 737
+ GW++LL++
Sbjct: 1918 QEVLQGWKELLSA 1930
Score = 48.5 bits (114), Expect = 3e-05
Identities = 71/308 (23%), Positives = 126/308 (40%), Gaps = 30/308 (9%)
Query: 264 AGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAM 323
A AE E R ++LA ++E K + +L ++ E RR PS S+M
Sbjct: 1815 AWAELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSM 1873
Query: 324 QRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWR 383
QR L F +L + + QL+ L+T H A E +++ +
Sbjct: 1874 QRTLRAFEHDLQL----LVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVL-------Q 1922
Query: 384 GLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHE--AWTRGKEEMLSQRDYDSALL 441
G +++ ED L + A+ R + + + +W G + D +
Sbjct: 1923 GWKELLSACEDARL-------HVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDV- 1974
Query: 442 QEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLG 501
V L+ H+ +++L A RV + QEL +++ QA Q D LG
Sbjct: 1975 SSVEVLMNYHQGLKTELEA---RVPELTT-CQELGRSLLLNKSAMADEIQA---QLDKLG 2027
Query: 502 TLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSL 561
T ++ + +R + L+ + ++ +FA+ A + WL LQ L SV+E + L
Sbjct: 2028 TRKEEVSEKWDRHWEWLQQMLEVH-QFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQL 2086
Query: 562 LTAHDQFK 569
+ H+ F+
Sbjct: 2087 IRRHEAFR 2094
Score = 44.3 bits (103), Expect = 5e-04
Identities = 100/469 (21%), Positives = 187/469 (39%), Gaps = 42/469 (8%)
Query: 342 IQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIR 401
++E + +F T + + A +EG L + E V + E +++R
Sbjct: 1234 VEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLR 1293
Query: 402 RLQRLQHLAEKFRQKASL---HEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDL 458
Q +Q L ++ + L HE E+ML RD ++ RH+AF ++L
Sbjct: 1294 AQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAEL 1353
Query: 459 AAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLL 518
A +++ +E I Q+L + AASV + I W L + TQ + L K
Sbjct: 1354 AQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK-- 1411
Query: 519 ETIDQLQLEFARRAAPFNNWLDGAVEDLQ---DVWLVHS-VEETQSLLTAHDQFKATLPE 574
DQL FA + ++ ++D+ D+ V+S +++ QS+ + +++ + E
Sbjct: 1412 --ADQLVQSFAELDKKLLH-MESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGE 1468
Query: 575 ADRERGAI------MGIQGEIQKICQTYGLR---PCSTNPYITLSPQ-------DINTKW 618
+ A+ + GE Q +R P + L+ + D++ +
Sbjct: 1469 LQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQVAHDLDDEL 1528
Query: 619 DMVRKLVPSRDQT-----LQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAG 673
V++ +P QT LQ + N+ LRR+ A GP ++ +E G LA+
Sbjct: 1529 AWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAH----GPRLEEVLERAGALASL 1584
Query: 674 LAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQ 733
+ E GL Q + + +R + Q+L + + + + +G EQ
Sbjct: 1585 RSPEAEAVRRGLEQLQSAWAGLREAAERRQ---QVLDAAFQVEQYYFDVAEVEAWLG-EQ 1640
Query: 734 LLTSIARTINEVENQVLTRDAKGLSQEQ-LNEFRASFNHFDRKRNGMME 781
L ++ + E L K L EQ + + S R+ ++E
Sbjct: 1641 ELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLE 1689
Score = 44.3 bits (103), Expect = 5e-04
Identities = 26/73 (35%), Positives = 41/73 (56%), Gaps = 3/73 (4%)
Query: 401 RRLQRLQHLAE--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDL 458
R + LQ + E +F Q+A + +AW +E +L R+ S++ EV L+RRHEAF
Sbjct: 2039 RHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSV-DEVEQLIRRHEAFRKAA 2097
Query: 459 AAHQDRVEHIAAL 471
AA ++R + L
Sbjct: 2098 AAWEERFSSLRRL 2110
Score = 36.6 bits (83), Expect = 0.11
Identities = 78/352 (22%), Positives = 139/352 (39%), Gaps = 57/352 (16%)
Query: 402 RLQRLQHLAEKFRQKASLH--EAWTRGKEE-MLSQRDYDSALLQEVRALLRRHEAFESDL 458
R Q L+ +R +H E W KE+ +LS R DS L +V + R E+ + ++
Sbjct: 873 RRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDS--LDDVEVVQHRFESLDQEM 930
Query: 459 AAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERM---- 514
+ RV + QEL E + + V S + +W+ + L ++R++ + +
Sbjct: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990
Query: 515 EKLLETID-QLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP 573
+LE + + Q+ RRA GA++ W + +E + L A + +A L
Sbjct: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQ-----WRLSGLE---AALQALEPRQAAL- 1041
Query: 574 EADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQ 633
E A++ + Q G +++ +W + S Q
Sbjct: 1042 ---LEEAALLAERFPAQAARLHQG-------------AEELGAEWG----ALASAAQACG 1081
Query: 634 EELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNII 693
E +A RL+R F +A W+ E G L SLEE A L +
Sbjct: 1082 EAVA---AAGRLQR-FLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAA--- 1134
Query: 694 NYKTNIDRLEGDHQLL---QESLVFDNKHTVYS-------MEHIRVGWEQLL 735
K +D+ E D+ + E+L+ + + + H+ +GW +LL
Sbjct: 1135 -LKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLL 1185
Score = 30.4 bits (67), Expect = 7.7
Identities = 59/268 (22%), Positives = 106/268 (39%), Gaps = 36/268 (13%)
Query: 402 RLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
RLQR H + F + G E L L+E ALL RH A + ++
Sbjct: 1089 RLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLARHAALKEEVDQR 1142
Query: 462 QDRVEHIAALAQELNELDYHE---AASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLL 518
++ I A ++ L D E +++ + W L L + RR+AL +
Sbjct: 1143 EEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAH--- 1199
Query: 519 ETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRE 578
I QL L R+A + A+ + V SVEE L H F T+ + ++
Sbjct: 1200 --IYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEA---LKQHRDFLTTMELSQQK 1254
Query: 579 -RGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
+ A+ +G +++ YG + + + R L +++ L+ +
Sbjct: 1255 MQVAVQAAEGLLRQ-GNIYGEQ----------------AQEAVTRLLEKNQENQLRAQQW 1297
Query: 638 RQQVNERLRRQ-FAAQANAIGPWIQAKV 664
Q+++++L Q F + + WI K+
Sbjct: 1298 MQKLHDQLELQHFLRDCHELDGWIHEKM 1325
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 345 bits (885), Expect = 1e-94
Identities = 209/564 (37%), Positives = 312/564 (55%), Gaps = 27/564 (4%)
Query: 45 KQQRKTFTAWCNSHLR--KAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFH 102
+ Q KTFT W N+ + +AG +I N+ + +G+ L+ LLE+ISGE LP P +G++R H
Sbjct: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78
Query: 103 KIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISVEET---- 158
+ N ++AL F+ +K V + IG E IVDG+ + LG+IW IILRF I IS+++
Sbjct: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137
Query: 159 -----SAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKD 213
S KE LL+WCQRKTA Y NVN+ +F SW DGL ALIH HRPDL+DY LR D
Sbjct: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197
Query: 214 DPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAA 273
P+ NL AF VAE+ L I ++LD ED+ +PDE++IMTYVS +YH + Q +T
Sbjct: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVA-AAQPDERSIMTYVSLYYHYCSRLHQGQTVQ 256
Query: 274 NRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDY 333
R+ K+L QE E L +YE+L ++LL WI LE R S+ AM++ L F +
Sbjct: 257 RRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIF 316
Query: 334 RRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYE 393
R KPPR+Q++ E LQT L+ +R F+P EG +++++ W GLE E
Sbjct: 317 RTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376
Query: 394 DWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEA 453
L + +LQRL+ LA +F+ KA+L E++ + E++L Q A L V A ++R
Sbjct: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436
Query: 454 FESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALER 513
E+ + + R + +A +A L + YH A V R + + +W L Q +R +
Sbjct: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQHLQGQRKQVAD 496
Query: 514 MEKLLETIDQL--------QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH 565
M+ +L + ++ +L+ R+ L VE LQ H + E Q ++AH
Sbjct: 497 MQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR----HDLLEAQ--VSAH 550
Query: 566 DQFKATLPEADRERGAIMGIQGEI 589
+ L + E + +G E+
Sbjct: 551 GAHVSHLAQQTAELDSSLGTSVEV 574
Score = 61.2 bits (147), Expect = 4e-09
Identities = 96/408 (23%), Positives = 166/408 (40%), Gaps = 36/408 (8%)
Query: 343 QEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRR 402
Q + + ++ Q + L AF+ L D+ R L Q K + L E R
Sbjct: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLLQRFKSLRE-PLQERRT 2852
Query: 403 LQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462
+ L KF + A AW + K + + +DY + L VR L +H+ ES++++H+
Sbjct: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQS-LSAVRHLQEQHQNLESEMSSHE 2911
Query: 463 DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522
+ +L + + A V +R Q + +L +RR L++ ++ + +
Sbjct: 2912 ALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLT 2971
Query: 523 QLQLEFARRAAPFNNWL--DGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERG 580
+L +WL G V D +D + HS E TQ+LL + K L EA R
Sbjct: 2972 EL--------LEAGSWLAERGHVLDSED--MGHSAEATQALLRRLEATKRDL-EAFSPR- 3019
Query: 581 AIMGIQGEIQKICQTYGL---RPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
I+++ QT L R +P + Q + + + +R LQE+L
Sbjct: 3020 --------IERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQL- 3070
Query: 638 RQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKT 697
Q+++ R A A+ ++ G+ G+ LEE+ R++ Q++ K
Sbjct: 3071 --QLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVK-VLEEKFDAFRKEVQSLGQAKV 3127
Query: 698 -NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSI-ARTIN 743
+ +L G L+ H I WE+L +I ART N
Sbjct: 3128 YALRKLAG---TLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTEN 3172
Score = 57.8 bits (138), Expect = 5e-08
Identities = 91/382 (23%), Positives = 149/382 (39%), Gaps = 49/382 (12%)
Query: 344 EKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYED-WLLSEIRR 402
++C+ E++ T L S + + SDI GLEQ E W +++
Sbjct: 2478 QECKAELDSWTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQL 2537
Query: 403 LQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462
Q L+ + F E W KE+ L+ L + LL +H+ E DL
Sbjct: 2538 QQALE--LQLFLSSVEKMERWLCSKEDSLASEGLWDPLAP-MEPLLWKHKMLEWDLEVQA 2594
Query: 463 DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERM-------- 514
++ + A A+ L++ + EA S RCQA+ + + L RR LE +
Sbjct: 2595 GKISALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQ 2654
Query: 515 ----------EKLLETIDQLQLEFA------RRAAPFNNWLDGAVEDLQDVWLVHSVEET 558
EK L +++ L+ A ++ F LD ++ Q++ E
Sbjct: 2655 DSQEVAAWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQEL-----QREG 2709
Query: 559 QSLLTAHDQFKATLPEADRERGAIMG-IQ-------GEIQKICQTYGLRPCSTNPYITLS 610
Q LL + E E GA+ G +Q ++QK C+ LR L
Sbjct: 2710 QRLLQGGHPASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLE 2769
Query: 611 PQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRL 670
P ++ + V + +P + E L Q+ E + A QA A+ QA V E
Sbjct: 2770 PIEVELRAPTVGQALPG----VGELLGTQRELEAAVDKKARQAEALLGQAQAFVRE---- 2821
Query: 671 AAGLAGSLEEQMAGLRQQEQNI 692
LA +EEQ L Q+ +++
Sbjct: 2822 GHCLAQDVEEQARRLLQRFKSL 2843
Score = 53.1 bits (126), Expect = 1e-06
Identities = 60/252 (23%), Positives = 106/252 (42%), Gaps = 36/252 (14%)
Query: 299 ELLEWIRRTVPWLENRVGEPSMSAMQRKLED-------FRDYRRLHKPPRIQEKCQLEIN 351
E L+ + W++ + + ++ + + LE R++R + + C I+
Sbjct: 2224 EFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSIS 2283
Query: 352 FNTLQTKLRLSHRPAFMPSEGKLV----SDIANAWRGLEQVEKGYEDWLLS--EIRRLQR 405
+LQ K R P E K++ S + N W Y+ L EI L R
Sbjct: 2284 DLSLQLKNR-------DPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336
Query: 406 -LQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
L ++ ++ ++K +L +A GK+ L+ V+ LLR+HE E ++ Q +
Sbjct: 2337 ELDNVTKRIQEKEALIQALDCGKD------------LESVQRLLRKHEELEREVHPIQAQ 2384
Query: 465 VEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRR---DALERMEKLLETI 521
VE + L + A + R Q + + W L + QKRR DAL + +KL +
Sbjct: 2385 VESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAML 2444
Query: 522 DQLQLEFARRAA 533
+L + R A
Sbjct: 2445 QELLVSAQRLRA 2456
Score = 48.5 bits (114), Expect = 3e-05
Identities = 30/118 (25%), Positives = 55/118 (46%), Gaps = 1/118 (0%)
Query: 409 LAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHI 468
L F Q A+ E W + + L + L +++ LL+ H+AFE+++ AH++ + +
Sbjct: 2115 LMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLK-HQAFEAEVQAHEEVMTSV 2173
Query: 469 AALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQL 526
A + L + A V+ R Q + W++L R LE LE + ++ L
Sbjct: 2174 AKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFLEFLQRVDL 2231
Score = 48.1 bits (113), Expect = 4e-05
Identities = 58/264 (21%), Positives = 106/264 (40%), Gaps = 45/264 (17%)
Query: 393 EDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHE 452
+ WL E LQ+ + F + H+AW L D ++E +LL++H
Sbjct: 1166 QQWL-QEGLELQKFGREVDGFTATCANHQAWLH-----LDNLGED---VREALSLLQQHR 1216
Query: 453 AFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALE 512
F L+ R E + A ++L + + A +V + Q+I QW L +++RR L
Sbjct: 1217 EFGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQL- 1275
Query: 513 RMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA-- 570
+ LQL+ W E +Q W+ E + L+ AH+ A
Sbjct: 1276 --------LASLQLQ---------EWKQDVAELMQ--WM-----EEKGLMAAHEPSGARR 1311
Query: 571 ----TLPEADRERGAIMGIQGEIQKICQT----YGLRPCSTNPYITLSPQDINTKWDMVR 622
TL + ++ + ++ + Q RPC I Q + +KW+ +
Sbjct: 1312 NILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQED-IQTRLQGLRSKWEALN 1370
Query: 623 KLVPSRDQTLQEELARQQVNERLR 646
+ + R LQ+ ++Q+ +L+
Sbjct: 1371 RKMTERGDELQQAGQQEQLLRQLQ 1394
Score = 47.4 bits (111), Expect = 6e-05
Identities = 78/362 (21%), Positives = 141/362 (38%), Gaps = 59/362 (16%)
Query: 368 MPSEGKL--VSDIANAWRGLEQVEKGYEDWLLSEIRRLQR---------LQHLAEKFRQK 416
+P EG+ +++IA+ R ++ Y W +++ R Q LQHL + +Q
Sbjct: 442 LPQEGRFQALAEIADILR-----QEQYHSW--ADVARRQEEVTVRWQRLLQHLQGQRKQV 494
Query: 417 ASLHEAWTRGKE--------EMLSQRDYDSAL---LQEVRALLRRHEAFESDLAAHQDRV 465
A + + +E E L + +A L EV LL+RH+ E+ ++AH V
Sbjct: 495 ADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVSAHGAHV 554
Query: 466 EHIAALAQELNELDYHEAASV---NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522
H LAQ+ ELD SV ++ + + +L L + RR LE+ +
Sbjct: 555 SH---LAQQTAELDSSLGTSVEVLQAKARTLAQLQQSLVALVRARRALLEQTLQ------ 605
Query: 523 QLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAI 582
+ EF R WL + + + L + + L H KA E R +
Sbjct: 606 --RAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKH---KALEAEVHRHQAVC 660
Query: 583 MGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVN 642
+ ++ + + R T P + + W +++ V R LQ L
Sbjct: 661 V----DLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTAL------ 710
Query: 643 ERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIIN-YKTNIDR 701
L Q+ A A W++ + + R + G + E + + + ++ + + R
Sbjct: 711 --LVLQYFADAAEAASWLRERRSSLERASCGQDQAAAETLLRRHVRLERVLRAFAAELRR 768
Query: 702 LE 703
LE
Sbjct: 769 LE 770
Score = 45.8 bits (107), Expect = 2e-04
Identities = 70/338 (20%), Positives = 128/338 (37%), Gaps = 25/338 (7%)
Query: 501 GTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQS 560
G Q+R L ++ L+ + LQ ++ + A W+ L+ S+ +
Sbjct: 252 GQTVQRR---LTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308
Query: 561 LLTAHDQFKAT-LPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWD 619
LL A F+ P ++RGA + +Q Q RP P+ L +++ W
Sbjct: 309 LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQAQNRRPFL--PHEGLGLAELSQCWA 366
Query: 620 MVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQ--AKVEEVGRLAAGLAGS 677
+ +R Q LQ+ L + Q E L R+F +A +++ +V + R +
Sbjct: 367 GLEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLAT 426
Query: 678 LEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTS 737
+E + L E I+ + L +L++ E + V W++LL
Sbjct: 427 VEAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARRQEEVTVRWQRLLQH 486
Query: 738 IARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPDDFRACLISMGYDLG 797
+ +V + L E A+ + + + EP AC G L
Sbjct: 487 LQGQRKQVADMQAVLSL-------LQEVEAASHQLEE----LQEPARSTAC----GQQLA 531
Query: 798 EVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTT 835
EV ++ D A V A + + ++TAE D++
Sbjct: 532 EV--VELLQRHDLLEAQVSAHGAHVSHLAQQTAELDSS 567
Score = 43.5 bits (101), Expect = 9e-04
Identities = 92/480 (19%), Positives = 181/480 (37%), Gaps = 89/480 (18%)
Query: 275 RICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYR 334
R C+ A + ++Y SEL W+ P +S+ ++ R
Sbjct: 1578 RACEARAQCLQQAVTFQQYFLDVSELEGWVEEK---------RPLVSSRDYGRDEAATLR 1628
Query: 335 RLHKPPRIQEKCQLEINFNTL----QTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEK 390
++K +QE +L I ++++ QT L+ +P + ++V + L + +
Sbjct: 1629 LINKHQALQE--ELAIYWSSMEELDQTAQTLTGPE--VPEQQRVVQE------RLREQLR 1678
Query: 391 GYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRR 450
++ + R L+ L E R+ L + W +++ + + L +
Sbjct: 1679 ALQELAATRDRELEGTLRLHEFLREAEDL-QGWLASQKQAAKGGESLGEDPEHALHLCTK 1737
Query: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
F+ + RV LA+ L E + V R Q + W L LTQ R A
Sbjct: 1738 FAKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHA 1797
Query: 511 LERME-------KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLT 563
L E LLE + Q+Q +A N DL + ++ L
Sbjct: 1798 LRDTETTLRVHRDLLEVLTQVQ----EKATSLPN---NVARDLCGL---------EAQLR 1841
Query: 564 AHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK 623
+H + L +R+ ++ G +QK+C P + Q + W ++++
Sbjct: 1842 SHQGLERELVGTERQLQELLETAGRVQKLC------PGPQAHAVQQRQQAVTQAWAVLQR 1895
Query: 624 LVPSRDQTLQEE--LAR------------QQVNERLRRQFAAQANAIGP-------WIQA 662
+ R L+ LAR +V + L+ + ++Q + GP W++A
Sbjct: 1896 RMEQRRAQLERARLLARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRA 1955
Query: 663 KVE----------EVGRLAAGLAGS----LEEQMAGLRQQEQNII-NYKTNIDRLEGDHQ 707
++E ++G+ A AG+ ++E++ L+ Q + + +RL+ + Q
Sbjct: 1956 ELEAREKLWQQATQLGQQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQ 2015
Score = 43.1 bits (100), Expect = 0.001
Identities = 83/429 (19%), Positives = 157/429 (36%), Gaps = 49/429 (11%)
Query: 285 ENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQE 344
E L+ ++ + A E + W++ +P + S+SA++ E ++
Sbjct: 2855 EARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEALT 2914
Query: 345 KCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQ 404
+ L + +Q +H A ++Q+EK RR
Sbjct: 2915 RVVLGTGYKLVQAGHFAAHEVAAR----------------VQQLEKAMAHLRAEAARRRL 2958
Query: 405 RLQHLAEKFRQKASLHEA--WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQ 462
LQ E + L EA W + +L D + + +ALLRR EA + DL A
Sbjct: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSA-EATQALLRRLEATKRDLEAFS 3017
Query: 463 DRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETID 522
R+E + A L E+ V ++ QA+ + L + R L+ +
Sbjct: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQ---------E 3068
Query: 523 QLQL-EFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
QLQL + R + WL + +E + L D F+ + + +
Sbjct: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAK-- 3126
Query: 582 IMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQV 641
++K+ T P+I I W+ + + + +R + L A +V
Sbjct: 3127 ----VYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENL---AAAHEV 3179
Query: 642 NERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDR 701
+ +Q AA+ +Q +++E L G G ++ +R +Q + ++
Sbjct: 3180 HS--FQQAAAE-------LQGRMQEKTALMKGEDGG--HSLSSVRTLQQQHRRLERELEA 3228
Query: 702 LEGDHQLLQ 710
+E + LQ
Sbjct: 3229 MEKEVARLQ 3237
Score = 39.3 bits (90), Expect = 0.017
Identities = 66/351 (18%), Positives = 135/351 (38%), Gaps = 35/351 (9%)
Query: 404 QRLQHLAEKFRQKASLHEA-----WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDL 458
QR + AE +++ L E+ W + L ++ S + + LLR H+ ++
Sbjct: 1058 QRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEV-SVDVASAQRLLREHQDLLEEI 1116
Query: 459 AAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALE---RME 515
Q+R++ + A +Q + LD ++ V + + + Q L L ++R+ L+ ++
Sbjct: 1117 HLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQ 1176
Query: 516 KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEA 575
K +D A A + LD ED V E SLL H +F L
Sbjct: 1177 KFGREVDGFTATCANHQAWLH--LDNLGED---------VREALSLLQQHREFGRLLSTL 1225
Query: 576 DRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEE 635
R + GE K+ Q+ P + + Q I +W +R Q E+
Sbjct: 1226 G-PRAEALRAHGE--KLVQSQ--HPAAHT--VREQLQSIQAQW--------TRLQGRSEQ 1270
Query: 636 LARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINY 695
RQ + +++ + W++ K +G ++ + + E ++
Sbjct: 1271 RRRQLLASLQLQEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLAT 1330
Query: 696 KTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVE 746
+ +++ L+ + L + ++ +R WE L + +E++
Sbjct: 1331 RRHVEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMTERGDELQ 1381
Score = 39.3 bits (90), Expect = 0.017
Identities = 44/199 (22%), Positives = 80/199 (40%), Gaps = 36/199 (18%)
Query: 328 EDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQ 387
+D R +RL K + QLE TL K M + + +A + LE+
Sbjct: 1414 QDLRSSQRLQKRHQ-----QLESESRTLAAK---------MAALASMAHGMAASPAILEE 1459
Query: 388 VEKGYEDWLLSEIRRLQRLQ-HLA------------EKFRQKASLHEAWTRGKEEMLSQR 434
+K +RRL+ LQ HLA +F +++ +W S
Sbjct: 1460 TQK--------HLRRLELLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPT 1511
Query: 435 DYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAIC 494
Y L ++L R+H+ + ++ AHQ +V+ + + + L + +A + +CQ +
Sbjct: 1512 SYTECL-NGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570
Query: 495 DQWDNLGTLTQKRRDALER 513
W L + R L++
Sbjct: 1571 GHWAELERACEARAQCLQQ 1589
Score = 39.3 bits (90), Expect = 0.017
Identities = 64/278 (23%), Positives = 112/278 (40%), Gaps = 32/278 (11%)
Query: 386 EQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVR 445
+Q ++ Y+ W + RLQ Q R+ L E +E+ + + ++EV
Sbjct: 1994 DQRDQVYQTWARKQ-ERLQAEQQEQLFLRECGRLEEILAA--QEVSLKTSALGSSVEEVE 2050
Query: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQ 505
L+R+HE F L A QD+ E AAL + L L V R + + + L +
Sbjct: 2051 QLIRKHEVFLKVLTA-QDKKE--AALRERLKTL---RRPRVRDRLPILLQRRMRVKELAE 2104
Query: 506 KRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAH 565
R AL L F + A +W+ + L++ + + L H
Sbjct: 2105 SRGHALH--------ASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKH 2156
Query: 566 DQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLV 625
F+A + +A E + +GE + Q++ ++ Q + W+ +R+ +
Sbjct: 2157 QAFEAEV-QAHEEVMTSVAKKGE-ALLAQSH-----PRAGEVSQRLQGLRKHWEDLRQAM 2209
Query: 626 PSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK 663
R Q L++ R+ E L+R A+A WIQ K
Sbjct: 2210 ALRGQELED---RRNFLEFLQRVDLAEA-----WIQEK 2239
Score = 34.7 bits (78), Expect = 0.41
Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 1/54 (1%)
Query: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
+K RQ+ EAW E +L + DY ++ +V LL RH+ E LAA +++
Sbjct: 3388 QKLRQRLEQAEAWLACWEGLLLKPDYGHSV-SDVELLLHRHQDLEKLLAAQEEK 3440
>gi|154759259 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 2 [Homo sapiens]
Length = 2472
Score = 260 bits (665), Expect = 4e-69
Identities = 156/500 (31%), Positives = 271/500 (54%), Gaps = 24/500 (4%)
Query: 412 KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAA-HQDRVEHIAA 470
+F KA + E+W KE L DY L V+ LL + E F++ L A Q+ + +I A
Sbjct: 1980 QFNWKADVVESWIGEKENSLKTDDYGRDL-SSVQTLLTKQETFDAGLQAFQQEGIANITA 2038
Query: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
L +L + ++ ++ +R ++ +W L + R+ L + ++ L L FA+
Sbjct: 2039 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2098
Query: 531 RAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQ 590
+A+ FN+W + A EDL D +S+EE ++L AHD F+++L A + + + +I+
Sbjct: 2099 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2158
Query: 591 KICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFA 650
++NPY + + + W ++K++ R+ LQ+E RQ+ N++LR++FA
Sbjct: 2159 SF-------RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2211
Query: 651 AQANAIGPWIQAKVEEV--GRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQL 708
ANA WIQ + G +G+LE Q+ +++ Q I ++ + ++E
Sbjct: 2212 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2271
Query: 709 LQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRAS 768
++E+L+ DNK+T +S + W+QL R + +E Q+ R+ G+++E L EF
Sbjct: 2272 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2331
Query: 769 FNHFDRKRNGMMEPDDFRACLISMGYDLGEV-------EFARIMTMVDPNAAGVVTFQAF 821
F HFD+ ++G + +F++CL S+GYDL V EF I+ VDPN G V+ Q +
Sbjct: 2332 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2391
Query: 822 IDFM-TRETAETDTTEQVVASFKILAGD-KNYITPEELRRELPAKQAEYCIRRMVPY--- 876
+ FM +RET ++E++ ++F+ L+ + K Y+T EEL + L +QA+YC+ M PY
Sbjct: 2392 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2451
Query: 877 KGSGAPAGALDYVAFSSALY 896
KG P A DYV F+ +L+
Sbjct: 2452 KGRELPT-AFDYVEFTRSLF 2470
Score = 77.0 bits (188), Expect = 7e-14
Identities = 90/428 (21%), Positives = 181/428 (42%), Gaps = 39/428 (9%)
Query: 362 SHRPAFMP--SEGKLVSDIANAWRGLEQVEKGY----EDWLLSEIRRL-----QRLQHLA 410
+H PA GK +SD G E++++ E W E+++L QRL+
Sbjct: 1815 AHEPAIQGVLDTGKKLSDDNTI--GKEEIQQRLAQFVEHW--KELKQLAAARGQRLEESL 1870
Query: 411 E--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHI 468
E +F EAW K +++ DY L ++ LL++HEAFE+D H+DRV +
Sbjct: 1871 EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAA-IQGLLKKHEAFETDFTVHKDRVNDV 1929
Query: 469 AALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEF 528
Q+L + + H +++S+ + + G ++ + A +R KL E + L+F
Sbjct: 1930 CTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE--NSAFLQF 1981
Query: 529 ARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGE 588
+A +W+ L+ + Q+LLT + F A L +E I I
Sbjct: 1982 NWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQE--GIANITAL 2039
Query: 589 IQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQ 648
++ ++ + I + +W + +R + L E + + E L
Sbjct: 2040 KDQLLAAKHVQ----SKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2095
Query: 649 FAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQ----EQNIINYKTNIDRLEG 704
FA +A+A W + E+ L + + E++ LR+ ++ + + + ++L
Sbjct: 2096 FAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2152
Query: 705 DHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNE 764
+ ++ V N +T ++ME + W L I E++ + ++ +++ +
Sbjct: 2153 LDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQ 2212
Query: 765 FRASFNHF 772
+F+ +
Sbjct: 2213 HANAFHQW 2220
Score = 64.7 bits (156), Expect = 4e-10
Identities = 56/212 (26%), Positives = 90/212 (42%), Gaps = 20/212 (9%)
Query: 375 VSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQR 434
+ ++ WR L+Q L E +L H ++F + A + W K + L+
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
Query: 435 DYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAIC 494
+Y L V+AL R+HE FE DLAA D+V + A+ L + A + +C +
Sbjct: 1260 NYGHDLAS-VQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 495 DQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHS 554
W +LG KR D +R KL ++ D LQ F +W++G + L
Sbjct: 1319 QAWSSLG----KRAD--QRKAKLGDSHD-LQ-RFLSDFRDLMSWINGIRGLVSSDELAKD 1370
Query: 555 VEETQSLLTAHDQFKATLPEADRERGAIMGIQ 586
V ++LL H + + E D G +
Sbjct: 1371 VTGAEALLERHQEHRT---EIDARAGTFQAFE 1399
Score = 58.9 bits (141), Expect = 2e-08
Identities = 70/310 (22%), Positives = 132/310 (42%), Gaps = 59/310 (19%)
Query: 287 EKLMEEYEKL--ASELLEWIRR---TVPWLENR--------VGEP--SMSAMQRKLEDFR 331
EK+ E+ KL A +L++++R + W+ ++ +G+ + +Q+K E+F+
Sbjct: 136 EKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQ 195
Query: 332 DYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVS----DIANAWRGLEQ 387
H+ R+ E N KL P E +L+ ++ AW+ L+
Sbjct: 196 TDMAAHEE-RVNE-------VNQFAAKLIQEQHP-----EEELIKTKQDEVNAAWQRLKG 242
Query: 388 VEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHE--AWTRGKEEMLSQRDYDSALLQEVR 445
+ ++R +L AE R + E +W + KE++++ D+ L V+
Sbjct: 243 LA----------LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLAS-VQ 291
Query: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQ 505
ALLR+HE E DLAA +D+V+ + A A L + A + + + + W+ + TL
Sbjct: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
Query: 506 KRRDALE---RMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLL 562
+R L R+++ L L +W+ + L V ++LL
Sbjct: 352 ERHARLNDSYRLQRFLADFRDL-----------TSWVTEMKALINADELASDVAGAEALL 400
Query: 563 TAHDQFKATL 572
H + K +
Sbjct: 401 DRHQEHKGEI 410
Score = 58.5 bits (140), Expect = 3e-08
Identities = 85/416 (20%), Positives = 164/416 (39%), Gaps = 60/416 (14%)
Query: 288 KLMEEYEKLA-SELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKC 346
+++E+ KL S+ L+ R V +E + E +A +D + + H+ + E
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQSKHQKHQAFE-A 1597
Query: 347 QLEINFNTLQTKLRLSH----RPAFMPSEGKL---VSDIANAWRGLEQVEKGYEDWLLSE 399
+L N + ++ + + + R A SE + ++ +A+ W+ L Q + + L E
Sbjct: 1598 ELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQKLKE 1656
Query: 400 IRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLA 459
+ Q + F + W E +L+ DY L V LL++H+ E+D++
Sbjct: 1657 ANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGKDLAS-VNNLLKKHQLLEADIS 1708
Query: 460 AHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLE 519
AH+DR++ + + A L + + V + I ++ + ++ RR L +L
Sbjct: 1709 AHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESHRL-- 1766
Query: 520 TIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRER 579
+F R +W+ + + Q+L H + +A E
Sbjct: 1767 ------HQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEA---ELAAHE 1817
Query: 580 GAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTK-------WDMVRKLVPSRDQTL 632
AI G+ +K+ T+ ++I + W +++L +R Q L
Sbjct: 1818 PAIQGVLDTGKKLSDDN-----------TIGKEEIQQRLAQFVEHWKELKQLAAARGQRL 1866
Query: 633 QEELARQQVNERLRRQFAAQANAIGPWIQAKV-----EEVGRLAAGLAGSLEEQMA 683
+E L Q QF A WI K+ E+ G A + G L++ A
Sbjct: 1867 EESLEYQ--------QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEA 1914
Score = 57.0 bits (136), Expect = 8e-08
Identities = 56/264 (21%), Positives = 106/264 (40%), Gaps = 36/264 (13%)
Query: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
++F + E W E L+ DY L V+ L ++H E+D+AAHQDR++ I
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITI 739
Query: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
A++ + + +A ++ + +A+ +++ L + + R +KL +++ QL R
Sbjct: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQL--FR 791
Query: 531 RAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP------EADRERGAIMG 584
W+ + Q+LL H +A + +A ++G M
Sbjct: 792 DVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMV 851
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNER 644
+G + ++N KW+ ++ R Q L++ L Q
Sbjct: 852 EEGHF-------------AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQ----- 893
Query: 645 LRRQFAAQANAIGPWIQAKVEEVG 668
Q+ A AN W++ K VG
Sbjct: 894 ---QYFADANEAESWMREKEPIVG 914
Score = 54.3 bits (129), Expect = 5e-07
Identities = 87/419 (20%), Positives = 165/419 (39%), Gaps = 52/419 (12%)
Query: 377 DIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ---HLAEKFRQKASLHEAWTRGKEEMLSQ 433
D N + E + YE + R Q+L L + FR E W R KE + +
Sbjct: 751 DAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED-EETWIREKEPIAAS 809
Query: 434 RDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI 493
+ L+ V+ LL++H+A ++++A H+ R++ + + E + A V ++ +
Sbjct: 810 TNRGKDLIG-VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
Query: 494 CDQWDNLGTLTQKRRDALERMEKLLETIDQLQL-EFARRAAPFNNWLDGAVEDLQDVWLV 552
+W+ L +RR LE D LQ ++ A +W+ +
Sbjct: 869 NQKWEALKAKASQRRQDLE---------DSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
Query: 553 HSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITL--- 609
+ ++LL H+ A + + +I ++ + Q Q T + L
Sbjct: 920 KDEDSAEALLKKHE---ALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
Query: 610 -----SPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKV 664
SP+++ K + L+ S + ++ + +VN+R AA + P A
Sbjct: 977 DYQEKSPREVTMKKGDILTLLNSTN----KDWWKVEVNDRQGFVPAAYVKKLDPAQSASR 1032
Query: 665 EEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSM 724
E + LEEQ + +QEQ I+ +T I + G L + V + H++ +
Sbjct: 1033 ENL----------LEEQGSIALRQEQ--IDNQTRITKEAGSVSLRMKQ-VEELYHSLLEL 1079
Query: 725 EHIRVGWEQLLTS---IARTINEVENQV------LTRDAKGLSQEQLNEFRASFNHFDR 774
R G + + R NE++ + LT + G EQ+ + F+ F +
Sbjct: 1080 GEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK 1138
Score = 48.5 bits (114), Expect = 3e-05
Identities = 70/338 (20%), Positives = 132/338 (39%), Gaps = 42/338 (12%)
Query: 405 RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
RLQ FR S W + +++ + S + ALL RH+ + ++ AH+D
Sbjct: 362 RLQRFLADFRDLTS----WVTEMKALINADELASDVAG-AEALLDRHQEHKGEIDAHEDS 416
Query: 465 VEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQL 524
+ Q L ++ + V + + ++ L L + RR E+ L
Sbjct: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-------DL 469
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
QL F R +NW+ L + L S++ ++LL H+ F+ +L + + A+
Sbjct: 470 QL-FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL-- 526
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELAR---QQV 641
+ + N Y + +D+ T+ R + SR L E R Q
Sbjct: 527 ---------DEFATKLIQNNHY---AMEDVATR----RDALLSRRNALHERAMRRRAQLA 570
Query: 642 NERLRRQFAAQANAIGPWIQAKV----EEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKT 697
+ +QF ++ + W+ K+ +E + + L G +++ A + N ++
Sbjct: 571 DSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSAN----QS 626
Query: 698 NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
ID LE Q L + + M + W++LL
Sbjct: 627 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
Score = 48.5 bits (114), Expect = 3e-05
Identities = 79/386 (20%), Positives = 145/386 (37%), Gaps = 43/386 (11%)
Query: 408 HLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEH 467
H +F + E+W + K+ ++ DY L V+ L ++H+ E++LAAH+ ++
Sbjct: 1764 HRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTG-VQNLRKKHKRLEAELAAHEPAIQG 1822
Query: 468 IAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE 527
+ ++L++ + + R + W L L R LE + + + ++ E
Sbjct: 1823 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1882
Query: 528 FARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP-EADRERGAIMGIQ 586
A W++ + + ++ Q LL H+ F+ DR Q
Sbjct: 1883 EA--------WINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQ 1934
Query: 587 GEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLR 646
I+K I+ + +N K + K R L E A Q N +
Sbjct: 1935 DLIKK--------NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWK-- 1984
Query: 647 RQFAAQANAIGPWI-----QAKVEEVGRLAAGLAGSLEEQM---AGLRQ-QEQNIINYKT 697
A+ + WI K ++ GR + + L +Q AGL+ Q++ I N
Sbjct: 1985 ------ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2038
Query: 698 NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL-TSIARTINEVENQVLTRDAKG 756
D+L + +S + +H + W QLL S AR +E Q R +
Sbjct: 2039 LKDQLLAAKHV--QSKAIEARHA-----SLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2091
Query: 757 LSQEQLNEFRASFNHFDRKRNGMMEP 782
L + A + F+ + +P
Sbjct: 2092 LFLTFAKKASAFNSWFENAEEDLTDP 2117
Score = 45.4 bits (106), Expect = 2e-04
Identities = 71/378 (18%), Positives = 144/378 (38%), Gaps = 36/378 (9%)
Query: 369 PSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ--HLAEKFRQKASLHEAWTRG 426
PS K++ + +QV Y + R Q+L+ + + F++ A E W +
Sbjct: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
K ++ S +Y ++ L++H+AFE+++ A+ + + + + + ++
Sbjct: 63 KLQIASDENYKDPT--NLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
Query: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDL 546
+R + QW+ L +K R E+ KLL+ Q +++ R +W++ +
Sbjct: 121 RTRLMELHRQWE---LLLEKMR---EKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
Query: 547 QDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606
L +E + L ++F+ + A ER E+ +
Sbjct: 173 TSEELGQDLEHVEVLQKKFEEFQTDM-AAHEER------VNEVNQFAAKLIQEQHPEEEL 225
Query: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK--- 663
I ++N W ++ L R L Q+ N + + WI+ K
Sbjct: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
Query: 664 --VEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTV 721
++ GR A + L + GL E+++ + + L + LQ+S
Sbjct: 278 MASDDFGRDLASVQALLRKH-EGL---ERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
Query: 722 YSMEHIRVGWEQLLTSIA 739
E + WEQ+ T A
Sbjct: 334 VKREELITNWEQIRTLAA 351
Score = 45.1 bits (105), Expect = 3e-04
Identities = 37/163 (22%), Positives = 76/163 (46%), Gaps = 17/163 (10%)
Query: 408 HLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEH 467
HL + FR L ++W K + + Y ++ +++H+AFE++L+A+Q R++
Sbjct: 574 HLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAELSANQSRIDA 630
Query: 468 IAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE 527
+ Q+L +++++ V +R + W L T+ + L + Q +
Sbjct: 631 LEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQ--------QQQ 682
Query: 528 FARRAAPFNNWL---DG--AVEDL-QDVWLVHSVEETQSLLTA 564
F R WL +G A +D +D+ V ++++ +LL A
Sbjct: 683 FNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725
Score = 43.5 bits (101), Expect = 9e-04
Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 17/180 (9%)
Query: 397 LSEIRRLQRLQHL-AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455
L E+RR Q Q + + F + + W +E L D +L V ALL++HE FE
Sbjct: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSL-DSVEALLKKHEDFE 513
Query: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALER-- 513
L+A ++++ + A +L + +++ V +R A+ RR+AL
Sbjct: 514 KSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-----------SRRNALHERA 562
Query: 514 MEKLLETIDQLQL-EFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATL 572
M + + D L +F R + +W++ ++ D Q + H F+A L
Sbjct: 563 MRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDE-AYKDPSNLQGKVQKHQAFEAEL 621
Score = 33.1 bits (74), Expect = 1.2
Identities = 64/309 (20%), Positives = 117/309 (37%), Gaps = 41/309 (13%)
Query: 290 MEEYEKLASELLEWIRRTVPWLE-NRVGEP--SMSAMQRKLEDFRDYRRLHKPPRIQEKC 346
++ + + A E EWI L + G S+ A+QRK E F ++
Sbjct: 1235 VQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFE-----------RDLA 1283
Query: 347 QLEINFNTL-QTKLRL--SHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRL 403
L N+L +T RL SH + + K +++ AW L + D +++
Sbjct: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKC-TELNQAWSSLGK----RADQRKAKLGDS 1338
Query: 404 QRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQD 463
LQ FR S W G ++S D + + ALL RH+ +++ A
Sbjct: 1339 HDLQRFLSDFRDLMS----WINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDARAG 1393
Query: 464 RVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRD---ALERMEKLLET 520
+ Q+L ++ + + + L L Q+R D A + +L+
Sbjct: 1394 TFQAFEQFGQQLLAHGHYASPEIKQK----------LDILDQERADLEKAWVQRRMMLDQ 1443
Query: 521 IDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERG 580
+LQL F R NW+ L S++ ++L+ H+ F + + +
Sbjct: 1444 CLELQL-FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIA 1502
Query: 581 AIMGIQGEI 589
A+ ++
Sbjct: 1503 ALQAFADQL 1511
Score = 31.2 bits (69), Expect = 4.5
Identities = 33/165 (20%), Positives = 71/165 (43%), Gaps = 21/165 (12%)
Query: 284 QENEKLMEEYEKLASELLEWIRRTVPWL--------ENRVGEPSMSAMQRKLEDFRDYRR 335
+EN+KL +E+ + A+ +WI+ T +L E+ E + A +RK ++ R R
Sbjct: 2201 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRS 2260
Query: 336 LHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDW 395
K ++E ++ L L ++ + G +A W L+Q+ +
Sbjct: 2261 QLK--------KIEDLGAAMEEALILDNKYTEHSTVG-----LAQQWDQLDQLGMRMQHN 2307
Query: 396 LLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSAL 440
L +I+ E ++ + + + + + K L+ +++ S L
Sbjct: 2308 LEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCL 2352
>gi|194595509 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)
isoform 1 [Homo sapiens]
Length = 2477
Score = 260 bits (665), Expect = 4e-69
Identities = 156/500 (31%), Positives = 271/500 (54%), Gaps = 24/500 (4%)
Query: 412 KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAA-HQDRVEHIAA 470
+F KA + E+W KE L DY L V+ LL + E F++ L A Q+ + +I A
Sbjct: 1985 QFNWKADVVESWIGEKENSLKTDDYGRDL-SSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
Query: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
L +L + ++ ++ +R ++ +W L + R+ L + ++ L L FA+
Sbjct: 2044 LKDQLLAAKHVQSKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLTFAK 2103
Query: 531 RAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQ 590
+A+ FN+W + A EDL D +S+EE ++L AHD F+++L A + + + +I+
Sbjct: 2104 KASAFNSWFENAEEDLTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAELDRQIK 2163
Query: 591 KICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFA 650
++NPY + + + W ++K++ R+ LQ+E RQ+ N++LR++FA
Sbjct: 2164 SF-------RVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFA 2216
Query: 651 AQANAIGPWIQAKVEEV--GRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQL 708
ANA WIQ + G +G+LE Q+ +++ Q I ++ + ++E
Sbjct: 2217 QHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRSQLKKIEDLGAA 2276
Query: 709 LQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRAS 768
++E+L+ DNK+T +S + W+QL R + +E Q+ R+ G+++E L EF
Sbjct: 2277 MEEALILDNKYTEHSTVGLAQQWDQLDQLGMRMQHNLEQQIQARNTTGVTEEALKEFSMM 2336
Query: 769 FNHFDRKRNGMMEPDDFRACLISMGYDLGEV-------EFARIMTMVDPNAAGVVTFQAF 821
F HFD+ ++G + +F++CL S+GYDL V EF I+ VDPN G V+ Q +
Sbjct: 2337 FKHFDKDKSGRLNHQEFKSCLRSLGYDLPMVEEGEPDPEFEAILDTVDPNRDGHVSLQEY 2396
Query: 822 IDFM-TRETAETDTTEQVVASFKILAGD-KNYITPEELRRELPAKQAEYCIRRMVPY--- 876
+ FM +RET ++E++ ++F+ L+ + K Y+T EEL + L +QA+YC+ M PY
Sbjct: 2397 MAFMISRETENVKSSEEIESAFRALSSEGKPYVTKEELYQNLTREQADYCVSHMKPYVDG 2456
Query: 877 KGSGAPAGALDYVAFSSALY 896
KG P A DYV F+ +L+
Sbjct: 2457 KGRELPT-AFDYVEFTRSLF 2475
Score = 77.0 bits (188), Expect = 7e-14
Identities = 90/428 (21%), Positives = 181/428 (42%), Gaps = 39/428 (9%)
Query: 362 SHRPAFMP--SEGKLVSDIANAWRGLEQVEKGY----EDWLLSEIRRL-----QRLQHLA 410
+H PA GK +SD G E++++ E W E+++L QRL+
Sbjct: 1820 AHEPAIQGVLDTGKKLSDDNTI--GKEEIQQRLAQFVEHW--KELKQLAAARGQRLEESL 1875
Query: 411 E--KFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHI 468
E +F EAW K +++ DY L ++ LL++HEAFE+D H+DRV +
Sbjct: 1876 EYQQFVANVEEEEAWINEKMTLVASEDYGDTLAA-IQGLLKKHEAFETDFTVHKDRVNDV 1934
Query: 469 AALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEF 528
Q+L + + H +++S+ + + G ++ + A +R KL E + L+F
Sbjct: 1935 CTNGQDLIKKNNHHEENISSKMKGL------NGKVSDLEKAAAQRKAKLDE--NSAFLQF 1986
Query: 529 ARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGE 588
+A +W+ L+ + Q+LLT + F A L +E I I
Sbjct: 1987 NWKADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQE--GIANITAL 2044
Query: 589 IQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQ 648
++ ++ + I + +W + +R + L E + + E L
Sbjct: 2045 KDQLLAAKHVQ----SKAIEARHASLMKRWSQLLANSAARKKKLLEAQSHFRKVEDLFLT 2100
Query: 649 FAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQ----EQNIINYKTNIDRLEG 704
FA +A+A W + E+ L + + E++ LR+ ++ + + + ++L
Sbjct: 2101 FAKKASAFNSWFENAEED---LTDPVRCNSLEEIKALREAHDAFRSSLSSAQADFNQLAE 2157
Query: 705 DHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNE 764
+ ++ V N +T ++ME + W L I E++ + ++ +++ +
Sbjct: 2158 LDRQIKSFRVASNPYTWFTMEALEETWRNLQKIIKERELELQKEQRRQEENDKLRQEFAQ 2217
Query: 765 FRASFNHF 772
+F+ +
Sbjct: 2218 HANAFHQW 2225
Score = 64.7 bits (156), Expect = 4e-10
Identities = 56/212 (26%), Positives = 90/212 (42%), Gaps = 20/212 (9%)
Query: 375 VSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQR 434
+ ++ WR L+Q L E +L H ++F + A + W K + L+
Sbjct: 1208 IKELNERWRSLQQ--------LAEERSQLLGSAHEVQRFHRDADETKEWIEEKNQALNTD 1259
Query: 435 DYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAIC 494
+Y L V+AL R+HE FE DLAA D+V + A+ L + A + +C +
Sbjct: 1260 NYGHDLAS-VQALQRKHEGFERDLAALGDKVNSLGETAERLIQSHPESAEDLQEKCTELN 1318
Query: 495 DQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHS 554
W +LG KR D +R KL ++ D LQ F +W++G + L
Sbjct: 1319 QAWSSLG----KRAD--QRKAKLGDSHD-LQ-RFLSDFRDLMSWINGIRGLVSSDELAKD 1370
Query: 555 VEETQSLLTAHDQFKATLPEADRERGAIMGIQ 586
V ++LL H + + E D G +
Sbjct: 1371 VTGAEALLERHQEHRT---EIDARAGTFQAFE 1399
Score = 58.9 bits (141), Expect = 2e-08
Identities = 70/310 (22%), Positives = 132/310 (42%), Gaps = 59/310 (19%)
Query: 287 EKLMEEYEKL--ASELLEWIRR---TVPWLENR--------VGEP--SMSAMQRKLEDFR 331
EK+ E+ KL A +L++++R + W+ ++ +G+ + +Q+K E+F+
Sbjct: 136 EKMREKGIKLLQAQKLVQYLRECEDVMDWINDKEAIVTSEELGQDLEHVEVLQKKFEEFQ 195
Query: 332 DYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVS----DIANAWRGLEQ 387
H+ R+ E N KL P E +L+ ++ AW+ L+
Sbjct: 196 TDMAAHEE-RVNE-------VNQFAAKLIQEQHP-----EEELIKTKQDEVNAAWQRLKG 242
Query: 388 VEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHE--AWTRGKEEMLSQRDYDSALLQEVR 445
+ ++R +L AE R + E +W + KE++++ D+ L V+
Sbjct: 243 LA----------LQRQGKLFGAAEVQRFNRDVDETISWIKEKEQLMASDDFGRDLAS-VQ 291
Query: 446 ALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQ 505
ALLR+HE E DLAA +D+V+ + A A L + A + + + + W+ + TL
Sbjct: 292 ALLRKHEGLERDLAALEDKVKALCAEADRLQQSHPLSATQIQVKREELITNWEQIRTLAA 351
Query: 506 KRRDALE---RMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLL 562
+R L R+++ L L +W+ + L V ++LL
Sbjct: 352 ERHARLNDSYRLQRFLADFRDL-----------TSWVTEMKALINADELASDVAGAEALL 400
Query: 563 TAHDQFKATL 572
H + K +
Sbjct: 401 DRHQEHKGEI 410
Score = 57.0 bits (136), Expect = 8e-08
Identities = 56/264 (21%), Positives = 106/264 (40%), Gaps = 36/264 (13%)
Query: 411 EKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAA 470
++F + E W E L+ DY L V+ L ++H E+D+AAHQDR++ I
Sbjct: 681 QQFNRNVEDIELWLYEVEGHLASDDYGKDLTN-VQNLQKKHALLEADVAAHQDRIDGITI 739
Query: 471 LAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
A++ + + +A ++ + +A+ +++ L + + R +KL +++ QL R
Sbjct: 740 QARQFQDAGHFDAENIKKKQEALVARYEAL------KEPMVARKQKLADSLRLQQL--FR 791
Query: 531 RAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP------EADRERGAIMG 584
W+ + Q+LL H +A + +A ++G M
Sbjct: 792 DVEDEETWIREKEPIAASTNRGKDLIGVQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMV 851
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNER 644
+G + ++N KW+ ++ R Q L++ L Q
Sbjct: 852 EEGHF-------------AAEDVKAKLHELNQKWEALKAKASQRRQDLEDSLQAQ----- 893
Query: 645 LRRQFAAQANAIGPWIQAKVEEVG 668
Q+ A AN W++ K VG
Sbjct: 894 ---QYFADANEAESWMREKEPIVG 914
Score = 55.5 bits (132), Expect = 2e-07
Identities = 85/420 (20%), Positives = 160/420 (38%), Gaps = 63/420 (15%)
Query: 288 KLMEEYEKLA-SELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKC 346
+++E+ KL S+ L+ R V +E + E +A +D + + + Q+
Sbjct: 1539 QMIEKRSKLGESQTLQQFSRDVDEIEAWISEKLQTASDESYKDPTNIQLSKLLSKHQKHQ 1598
Query: 347 QLEINFNTLQTKLR--------LSHRPAFMPSEGKL---VSDIANAWRGLEQVEKGYEDW 395
E + ++R L R A SE + ++ +A+ W+ L Q + +
Sbjct: 1599 AFEAELHANADRIRGVIDMGNSLIERGACAGSEDAVKARLAALADQWQFLVQ-KSAEKSQ 1657
Query: 396 LLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455
L E + Q + F + W E +L+ DY L V LL++H+ E
Sbjct: 1658 KLKEANKQQNFNTGIKDF-------DFWLSEVEALLASEDYGKDLAS-VNNLLKKHQLLE 1709
Query: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERME 515
+D++AH+DR++ + + A L + + V + I ++ + ++ RR L
Sbjct: 1710 ADISAHEDRLKDLNSQADSLMTSSAFDTSQVKDKRDTINGRFQKIKSMAASRRAKLNESH 1769
Query: 516 KLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEA 575
+L +F R +W+ + + Q+L H + +A E
Sbjct: 1770 RL--------HQFFRDMDDEESWIKEKKLLVGSEDYGRDLTGVQNLRKKHKRLEA---EL 1818
Query: 576 DRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTK-------WDMVRKLVPSR 628
AI G+ +K+ T+ ++I + W +++L +R
Sbjct: 1819 AAHEPAIQGVLDTGKKLSDDN-----------TIGKEEIQQRLAQFVEHWKELKQLAAAR 1867
Query: 629 DQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKV-----EEVGRLAAGLAGSLEEQMA 683
Q L+E L Q QF A WI K+ E+ G A + G L++ A
Sbjct: 1868 GQRLEESLEYQ--------QFVANVEEEEAWINEKMTLVASEDYGDTLAAIQGLLKKHEA 1919
Score = 54.3 bits (129), Expect = 5e-07
Identities = 87/419 (20%), Positives = 165/419 (39%), Gaps = 52/419 (12%)
Query: 377 DIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ---HLAEKFRQKASLHEAWTRGKEEMLSQ 433
D N + E + YE + R Q+L L + FR E W R KE + +
Sbjct: 751 DAENIKKKQEALVARYEALKEPMVARKQKLADSLRLQQLFRDVED-EETWIREKEPIAAS 809
Query: 434 RDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI 493
+ L+ V+ LL++H+A ++++A H+ R++ + + E + A V ++ +
Sbjct: 810 TNRGKDLIG-VQNLLKKHQALQAEIAGHEPRIKAVTQKGNAMVEEGHFAAEDVKAKLHEL 868
Query: 494 CDQWDNLGTLTQKRRDALERMEKLLETIDQLQL-EFARRAAPFNNWLDGAVEDLQDVWLV 552
+W+ L +RR LE D LQ ++ A +W+ +
Sbjct: 869 NQKWEALKAKASQRRQDLE---------DSLQAQQYFADANEAESWMREKEPIVGSTDYG 919
Query: 553 HSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITL--- 609
+ ++LL H+ A + + +I ++ + Q Q T + L
Sbjct: 920 KDEDSAEALLKKHE---ALMSDLSAYGSSIQALREQAQSCRQQVAPTDDETGKELVLALY 976
Query: 610 -----SPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKV 664
SP+++ K + L+ S + ++ + +VN+R AA + P A
Sbjct: 977 DYQEKSPREVTMKKGDILTLLNSTN----KDWWKVEVNDRQGFVPAAYVKKLDPAQSASR 1032
Query: 665 EEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSM 724
E + LEEQ + +QEQ I+ +T I + G L + V + H++ +
Sbjct: 1033 ENL----------LEEQGSIALRQEQ--IDNQTRITKEAGSVSLRMKQ-VEELYHSLLEL 1079
Query: 725 EHIRVGWEQLLTS---IARTINEVENQV------LTRDAKGLSQEQLNEFRASFNHFDR 774
R G + + R NE++ + LT + G EQ+ + F+ F +
Sbjct: 1080 GEKRKGMLEKSCKKFMLFREANELQQWINEKEAALTSEEVGADLEQVEVLQKKFDDFQK 1138
Score = 48.5 bits (114), Expect = 3e-05
Identities = 70/338 (20%), Positives = 132/338 (39%), Gaps = 42/338 (12%)
Query: 405 RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
RLQ FR S W + +++ + S + ALL RH+ + ++ AH+D
Sbjct: 362 RLQRFLADFRDLTS----WVTEMKALINADELASDVAG-AEALLDRHQEHKGEIDAHEDS 416
Query: 465 VEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQL 524
+ Q L ++ + V + + ++ L L + RR E+ L
Sbjct: 417 FKSADESGQALLAAGHYASDEVREKLTVLSEERAALLELWELRRQQYEQCM-------DL 469
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
QL F R +NW+ L + L S++ ++LL H+ F+ +L + + A+
Sbjct: 470 QL-FYRDTEQVDNWMSKQEAFLLNEDLGDSLDSVEALLKKHEDFEKSLSAQEEKITAL-- 526
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELAR---QQV 641
+ + N Y + +D+ T+ R + SR L E R Q
Sbjct: 527 ---------DEFATKLIQNNHY---AMEDVATR----RDALLSRRNALHERAMRRRAQLA 570
Query: 642 NERLRRQFAAQANAIGPWIQAKV----EEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKT 697
+ +QF ++ + W+ K+ +E + + L G +++ A + N ++
Sbjct: 571 DSFHLQQFFRDSDELKSWVNEKMKTATDEAYKDPSNLQGKVQKHQAFEAELSAN----QS 626
Query: 698 NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
ID LE Q L + + M + W++LL
Sbjct: 627 RIDALEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLL 664
Score = 48.5 bits (114), Expect = 3e-05
Identities = 79/386 (20%), Positives = 145/386 (37%), Gaps = 43/386 (11%)
Query: 408 HLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEH 467
H +F + E+W + K+ ++ DY L V+ L ++H+ E++LAAH+ ++
Sbjct: 1769 HRLHQFFRDMDDEESWIKEKKLLVGSEDYGRDLTG-VQNLRKKHKRLEAELAAHEPAIQG 1827
Query: 468 IAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE 527
+ ++L++ + + R + W L L R LE + + + ++ E
Sbjct: 1828 VLDTGKKLSDDNTIGKEEIQQRLAQFVEHWKELKQLAAARGQRLEESLEYQQFVANVEEE 1887
Query: 528 FARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLP-EADRERGAIMGIQ 586
A W++ + + ++ Q LL H+ F+ DR Q
Sbjct: 1888 EA--------WINEKMTLVASEDYGDTLAAIQGLLKKHEAFETDFTVHKDRVNDVCTNGQ 1939
Query: 587 GEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLR 646
I+K I+ + +N K + K R L E A Q N +
Sbjct: 1940 DLIKK--------NNHHEENISSKMKGLNGKVSDLEKAAAQRKAKLDENSAFLQFNWK-- 1989
Query: 647 RQFAAQANAIGPWI-----QAKVEEVGRLAAGLAGSLEEQM---AGLRQ-QEQNIINYKT 697
A+ + WI K ++ GR + + L +Q AGL+ Q++ I N
Sbjct: 1990 ------ADVVESWIGEKENSLKTDDYGRDLSSVQTLLTKQETFDAGLQAFQQEGIANITA 2043
Query: 698 NIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL-TSIARTINEVENQVLTRDAKG 756
D+L + +S + +H + W QLL S AR +E Q R +
Sbjct: 2044 LKDQLLAAKHV--QSKAIEARHA-----SLMKRWSQLLANSAARKKKLLEAQSHFRKVED 2096
Query: 757 LSQEQLNEFRASFNHFDRKRNGMMEP 782
L + A + F+ + +P
Sbjct: 2097 LFLTFAKKASAFNSWFENAEEDLTDP 2122
Score = 45.4 bits (106), Expect = 2e-04
Identities = 71/378 (18%), Positives = 144/378 (38%), Gaps = 36/378 (9%)
Query: 369 PSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQ--HLAEKFRQKASLHEAWTRG 426
PS K++ + +QV Y + R Q+L+ + + F++ A E W +
Sbjct: 3 PSGVKVLETAEDIQERRQQVLDRYHRFKELSTLRRQKLEDSYRFQFFQRDAEELEKWIQE 62
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
K ++ S +Y ++ L++H+AFE+++ A+ + + + + + ++
Sbjct: 63 KLQIASDENYKDPT--NLQGKLQKHQAFEAEVQANSGAIVKLDETGNLMISEGHFASETI 120
Query: 487 NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDL 546
+R + QW+ L +K R E+ KLL+ Q +++ R +W++ +
Sbjct: 121 RTRLMELHRQWE---LLLEKMR---EKGIKLLQA--QKLVQYLRECEDVMDWINDKEAIV 172
Query: 547 QDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606
L +E + L ++F+ + A ER E+ +
Sbjct: 173 TSEELGQDLEHVEVLQKKFEEFQTDM-AAHEER------VNEVNQFAAKLIQEQHPEEEL 225
Query: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK--- 663
I ++N W ++ L R L Q+ N + + WI+ K
Sbjct: 226 IKTKQDEVNAAWQRLKGLALQRQGKLFGAAEVQRFNRDVDETIS--------WIKEKEQL 277
Query: 664 --VEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTV 721
++ GR A + L + GL E+++ + + L + LQ+S
Sbjct: 278 MASDDFGRDLASVQALLRKH-EGL---ERDLAALEDKVKALCAEADRLQQSHPLSATQIQ 333
Query: 722 YSMEHIRVGWEQLLTSIA 739
E + WEQ+ T A
Sbjct: 334 VKREELITNWEQIRTLAA 351
Score = 45.1 bits (105), Expect = 3e-04
Identities = 37/163 (22%), Positives = 76/163 (46%), Gaps = 17/163 (10%)
Query: 408 HLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEH 467
HL + FR L ++W K + + Y ++ +++H+AFE++L+A+Q R++
Sbjct: 574 HLQQFFRDSDEL-KSWVNEKMKTATDEAYKDP--SNLQGKVQKHQAFEAELSANQSRIDA 630
Query: 468 IAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLE 527
+ Q+L +++++ V +R + W L T+ + L + Q +
Sbjct: 631 LEKAGQKLIDVNHYAKDEVAARMNEVISLWKKLLEATELKGIKLREANQ--------QQQ 682
Query: 528 FARRAAPFNNWL---DG--AVEDL-QDVWLVHSVEETQSLLTA 564
F R WL +G A +D +D+ V ++++ +LL A
Sbjct: 683 FNRNVEDIELWLYEVEGHLASDDYGKDLTNVQNLQKKHALLEA 725
Score = 43.5 bits (101), Expect = 9e-04
Identities = 43/180 (23%), Positives = 77/180 (42%), Gaps = 17/180 (9%)
Query: 397 LSEIRRLQRLQHL-AEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455
L E+RR Q Q + + F + + W +E L D +L V ALL++HE FE
Sbjct: 455 LWELRRQQYEQCMDLQLFYRDTEQVDNWMSKQEAFLLNEDLGDSL-DSVEALLKKHEDFE 513
Query: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALER-- 513
L+A ++++ + A +L + +++ V +R A+ RR+AL
Sbjct: 514 KSLSAQEEKITALDEFATKLIQNNHYAMEDVATRRDALL-----------SRRNALHERA 562
Query: 514 MEKLLETIDQLQL-EFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATL 572
M + + D L +F R + +W++ ++ D Q + H F+A L
Sbjct: 563 MRRRAQLADSFHLQQFFRDSDELKSWVNEKMKTATDE-AYKDPSNLQGKVQKHQAFEAEL 621
Score = 33.1 bits (74), Expect = 1.2
Identities = 64/309 (20%), Positives = 117/309 (37%), Gaps = 41/309 (13%)
Query: 290 MEEYEKLASELLEWIRRTVPWLE-NRVGEP--SMSAMQRKLEDFRDYRRLHKPPRIQEKC 346
++ + + A E EWI L + G S+ A+QRK E F ++
Sbjct: 1235 VQRFHRDADETKEWIEEKNQALNTDNYGHDLASVQALQRKHEGFE-----------RDLA 1283
Query: 347 QLEINFNTL-QTKLRL--SHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRL 403
L N+L +T RL SH + + K +++ AW L + D +++
Sbjct: 1284 ALGDKVNSLGETAERLIQSHPESAEDLQEKC-TELNQAWSSLGK----RADQRKAKLGDS 1338
Query: 404 QRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQD 463
LQ FR S W G ++S D + + ALL RH+ +++ A
Sbjct: 1339 HDLQRFLSDFRDLMS----WINGIRGLVSS-DELAKDVTGAEALLERHQEHRTEIDARAG 1393
Query: 464 RVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRD---ALERMEKLLET 520
+ Q+L ++ + + + L L Q+R D A + +L+
Sbjct: 1394 TFQAFEQFGQQLLAHGHYASPEIKQK----------LDILDQERADLEKAWVQRRMMLDQ 1443
Query: 521 IDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERG 580
+LQL F R NW+ L S++ ++L+ H+ F + + +
Sbjct: 1444 CLELQL-FHRDCEQAENWMAAREAFLNTEDKGDSLDSVEALIKKHEDFDKAINVQEEKIA 1502
Query: 581 AIMGIQGEI 589
A+ ++
Sbjct: 1503 ALQAFADQL 1511
Score = 31.2 bits (69), Expect = 4.5
Identities = 33/165 (20%), Positives = 71/165 (43%), Gaps = 21/165 (12%)
Query: 284 QENEKLMEEYEKLASELLEWIRRTVPWL--------ENRVGEPSMSAMQRKLEDFRDYRR 335
+EN+KL +E+ + A+ +WI+ T +L E+ E + A +RK ++ R R
Sbjct: 2206 EENDKLRQEFAQHANAFHQWIQETRTYLLDGSCMVEESGTLESQLEATKRKHQEIRAMRS 2265
Query: 336 LHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDW 395
K ++E ++ L L ++ + G +A W L+Q+ +
Sbjct: 2266 QLK--------KIEDLGAAMEEALILDNKYTEHSTVG-----LAQQWDQLDQLGMRMQHN 2312
Query: 396 LLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSAL 440
L +I+ E ++ + + + + + K L+ +++ S L
Sbjct: 2313 LEQQIQARNTTGVTEEALKEFSMMFKHFDKDKSGRLNHQEFKSCL 2357
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 252 bits (643), Expect = 1e-66
Identities = 210/674 (31%), Positives = 316/674 (46%), Gaps = 52/674 (7%)
Query: 7 PEGLGAGEGRFAGGGGGGEYMEQEEDWDRDLL-LDPAWEKQQRKTFTAWCNSHLRKAGTQ 65
P LG + GGG G + +R ++ + ++ Q+KTFT W N HL KA
Sbjct: 30 PWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIRIADERDRVQKKTFTKWVNKHLIKAQRH 89
Query: 66 IENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIG 125
I ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFHK+ NV ALD++ + VKLV+I
Sbjct: 90 ISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLRHRQVKLVNIR 148
Query: 126 AEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETSAKEGLLLWCQRKTAPYRNVNVQ 181
++I DGN K+TLG+IWTIIL F I DI V E+ +AKE LLLW QR Y+ +
Sbjct: 149 NDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCD 208
Query: 182 NFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDI 241
NF +SW+DG A+IHRH+P LID K+ + + NL+ AF VAE+ L + ++LD ED
Sbjct: 209 NFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED- 267
Query: 242 VNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELL 301
V+ P+PDEK+I+TYVS Y A + E + +EY +L LL
Sbjct: 268 VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA--------NELQLRWQEYRELVLLLL 319
Query: 302 EWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKL-- 359
+W+R E R S ++ F ++ + P + +K + + + +L+ +
Sbjct: 320 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQA 379
Query: 360 -RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKAS 418
+L P + P D+ W L E L SE RL+ LQ + K + +A
Sbjct: 380 GQLKVPPGYHP------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAG 433
Query: 419 LHEAWTRGKEEMLSQRDYDSALLQ-EVRALL-----RRHEAFESDLAAHQDRVEHIAALA 472
L EE L+Q D ALLQ +VR L +R E DL + +
Sbjct: 434 L-------CEEQLNQAD---ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV 483
Query: 473 QELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRA 532
Q L + + + + R + ++ + T R A + + Q+ L+ +R
Sbjct: 484 QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA--GVAAPATQVAQVTLQSVQRR 541
Query: 533 APFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKI 592
D + LQD L+ VEE Q + ++ LP + + G+ G+ I++
Sbjct: 542 PELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGVDLPSVEAQLGSHRGLHQSIEEF 595
Query: 593 CQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQ 652
LSP D + +L + L AR + E L F A
Sbjct: 596 RAKIERARSDEG---QLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL-HSFVAA 651
Query: 653 ANAIGPWIQAKVEE 666
A W+ K EE
Sbjct: 652 ATKELMWLNEKEEE 665
Score = 44.7 bits (104), Expect = 4e-04
Identities = 116/589 (19%), Positives = 224/589 (38%), Gaps = 62/589 (10%)
Query: 219 LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI-- 276
L A E A+K L + A + + ++ + S AE A AA
Sbjct: 2063 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2122
Query: 277 CKVLAVNQ--ENEKLMEEYEKL-------------ASELLEWIRRTVPWLENRVGEPSMS 321
+V A + ++ + +EE E+L A E +R+ R + +
Sbjct: 2123 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2182
Query: 322 AMQRKLEDFRDYRRLHK--PPRIQEKCQLEINFNTLQTKLR-LSHRPAFMPSE-GKLVSD 377
A+++K + + K +++K Q+E TL+ +L H+ + E +L ++
Sbjct: 2183 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2242
Query: 378 IANAWRGLEQVEKGY---------------------EDWLLSEIRRLQR-LQHLAEKFRQ 415
A R QVE+ +L + QR LQ AEK +Q
Sbjct: 2243 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2302
Query: 416 KASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL 475
A + +E R L + RAL + + R++ A L Q+
Sbjct: 2303 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2362
Query: 476 NELDYHEAASVNSRCQAICDQW--DNLG---TLTQKRRDAL------ERMEKLLETIDQL 524
EL +A + + + Q + G TL +R+ L ER++ + + +
Sbjct: 2363 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2422
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Q A F + E L L + E+ + T Q + + +A+R R AI
Sbjct: 2423 QARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2481
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK-LVPSRDQTLQEELARQQVNE 643
++ E +K+ Q L + T+ + + + +++ + +D LQ E +Q
Sbjct: 2482 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2541
Query: 644 RLRRQF---AAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+L + F A+A + Q + +++ + L S+EE + E+ + + +
Sbjct: 2542 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2601
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQV 749
+LE + +E L +N+ E +++ EQ ++A + +QV
Sbjct: 2602 QLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2647
Score = 40.0 bits (92), Expect = 0.010
Identities = 95/511 (18%), Positives = 200/511 (39%), Gaps = 32/511 (6%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRK 326
E+AE A + + +E E+ +E ++ A+E L +R + + A ++K
Sbjct: 1635 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1693
Query: 327 LEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAF--MPSEGKLVSDIANAWRG 384
E R+ RR K Q Q E+ L+ + +L+ A + +E +L+ A +G
Sbjct: 1694 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1752
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML-----SQRDYDSA 439
+Q L E+ RLQR A + RQ+ A R + E+L + +
Sbjct: 1753 EQQ-----RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1807
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI-CDQWD 498
++ + L +LA R+ +A A+ +L +AA + + + ++
Sbjct: 1808 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1867
Query: 499 NLGTLTQKRRDA---LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSV 555
+G T+ + +A L+ E E + +L + A + D+++
Sbjct: 1868 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1927
Query: 556 EETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDIN 615
L + TL + + I+ ++ +K + + +
Sbjct: 1928 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1987
Query: 616 TKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLA 675
+K + R +EE R++ ER+++ AA+ A +A +EEV RL A +
Sbjct: 1988 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKV- 2045
Query: 676 GSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
E+ LR++ + + + +L+ + Q+ L + K ++++ +Q L
Sbjct: 2046 ----EEARRLRERAE-----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2096
Query: 736 TSIARTINEVENQVLTRDAKGLSQEQLNEFR 766
++++ + +A + E+ E R
Sbjct: 2097 QQEQSVLDQLRGEA---EAARRAAEEAEEAR 2124
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 249 bits (636), Expect = 8e-66
Identities = 207/656 (31%), Positives = 308/656 (46%), Gaps = 59/656 (8%)
Query: 24 GEYMEQEEDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLL 83
G Q+E +RD + Q+KTFT W N HL KA I ++ ED R+G L+ LL
Sbjct: 29 GRRWAQDEQDERD--------RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLL 80
Query: 84 EVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWT 143
EV+SG+ LPR +KG+MRFHK+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWT
Sbjct: 81 EVLSGDSLPR-EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWT 139
Query: 144 IILRFAIQDISV----EETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHR 199
IIL F I DI V E+ +AKE LLLW QR Y+ + NF +SW+DG A+IHR
Sbjct: 140 IILHFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHR 199
Query: 200 HRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCF 259
H+P LID K+ + + NL+ AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS
Sbjct: 200 HKPLLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSL 258
Query: 260 YHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPS 319
Y A + E + +EY +L LL+W+R E R S
Sbjct: 259 YDAMPRVPDVQDGVRA--------NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSS 310
Query: 320 MSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVS 376
++ F ++ + P + +K + + + +L+ + +L P + P
Sbjct: 311 FEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------L 364
Query: 377 DIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDY 436
D+ W L E L SE RL+ LQ + K + +A L EE L+Q D
Sbjct: 365 DVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL-------CEEQLNQAD- 416
Query: 437 DSALLQ-EVRALL-----RRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRC 490
ALLQ +VR L +R E DL + + Q L + + + + R
Sbjct: 417 --ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRV 474
Query: 491 QAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVW 550
+ ++ + T R A + + Q+ L+ +R D + LQD
Sbjct: 475 YRLHERLVAIRTEYNLRLKA--GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD-- 527
Query: 551 LVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLS 610
L+ VEE Q + ++ LP + + G+ G+ I++ LS
Sbjct: 528 LLAWVEENQHRVDG-AEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---QLS 583
Query: 611 PQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
P D + +L + L AR + E L F A A W+ K EE
Sbjct: 584 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 638
Score = 44.7 bits (104), Expect = 4e-04
Identities = 116/589 (19%), Positives = 224/589 (38%), Gaps = 62/589 (10%)
Query: 219 LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI-- 276
L A E A+K L + A + + ++ + S AE A AA
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 277 CKVLAVNQ--ENEKLMEEYEKL-------------ASELLEWIRRTVPWLENRVGEPSMS 321
+V A + ++ + +EE E+L A E +R+ R + +
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 322 AMQRKLEDFRDYRRLHK--PPRIQEKCQLEINFNTLQTKLR-LSHRPAFMPSE-GKLVSD 377
A+++K + + K +++K Q+E TL+ +L H+ + E +L ++
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
Query: 378 IANAWRGLEQVEKGY---------------------EDWLLSEIRRLQR-LQHLAEKFRQ 415
A R QVE+ +L + QR LQ AEK +Q
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 416 KASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL 475
A + +E R L + RAL + + R++ A L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 476 NELDYHEAASVNSRCQAICDQW--DNLG---TLTQKRRDAL------ERMEKLLETIDQL 524
EL +A + + + Q + G TL +R+ L ER++ + + +
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Q A F + E L L + E+ + T Q + + +A+R R AI
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK-LVPSRDQTLQEELARQQVNE 643
++ E +K+ Q L + T+ + + + +++ + +D LQ E +Q
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 644 RLRRQF---AAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+L + F A+A + Q + +++ + L S+EE + E+ + + +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQV 749
+LE + +E L +N+ E +++ EQ ++A + +QV
Sbjct: 2575 QLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 40.0 bits (92), Expect = 0.010
Identities = 95/511 (18%), Positives = 200/511 (39%), Gaps = 32/511 (6%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRK 326
E+AE A + + +E E+ +E ++ A+E L +R + + A ++K
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 327 LEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAF--MPSEGKLVSDIANAWRG 384
E R+ RR K Q Q E+ L+ + +L+ A + +E +L+ A +G
Sbjct: 1667 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML-----SQRDYDSA 439
+Q L E+ RLQR A + RQ+ A R + E+L + +
Sbjct: 1726 EQQ-----RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI-CDQWD 498
++ + L +LA R+ +A A+ +L +AA + + + ++
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 499 NLGTLTQKRRDA---LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSV 555
+G T+ + +A L+ E E + +L + A + D+++
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 556 EETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDIN 615
L + TL + + I+ ++ +K + + +
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 616 TKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLA 675
+K + R +EE R++ ER+++ AA+ A +A +EEV RL A +
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKV- 2018
Query: 676 GSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
E+ LR++ + + + +L+ + Q+ L + K ++++ +Q L
Sbjct: 2019 ----EEARRLRERAE-----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 736 TSIARTINEVENQVLTRDAKGLSQEQLNEFR 766
++++ + +A + E+ E R
Sbjct: 2070 QQEQSVLDQLRGEA---EAARRAAEEAEEAR 2097
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 248 bits (634), Expect = 1e-65
Identities = 202/636 (31%), Positives = 302/636 (47%), Gaps = 51/636 (8%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
++ Q+KTFT W N HL KA I ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFHK
Sbjct: 41 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 99
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 100 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 159
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW QR Y+ + NF +SW+DG A+IHRH+P LID K+ + + NL
Sbjct: 160 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 219
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
+ AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS Y A +
Sbjct: 220 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 274
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
E + +EY +L LL+W+R E R S ++ F ++ + P
Sbjct: 275 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 330
Query: 340 PRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
+ +K + + + +L+ + +L P + P D+ W L E L
Sbjct: 331 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 384
Query: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQ-EVRALL-----RR 450
SE RL+ LQ + K + +A L EE L+Q D ALLQ +VR L +R
Sbjct: 385 RSEFERLECLQRIVTKLQMEAGL-------CEEQLNQAD---ALLQSDVRLLAAGKVPQR 434
Query: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
E DL + + Q L + + + + R + ++ + T R A
Sbjct: 435 AGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 494
Query: 511 LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA 570
+ + Q+ L+ +R D + LQD L+ VEE Q + ++
Sbjct: 495 --GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGV 546
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
LP + + G+ G+ I++ LSP D + +L +
Sbjct: 547 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---QLSPATRGAYRDCLGRLDLQYAK 603
Query: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
L AR + E L F A A W+ K EE
Sbjct: 604 LLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 638
Score = 44.7 bits (104), Expect = 4e-04
Identities = 116/589 (19%), Positives = 224/589 (38%), Gaps = 62/589 (10%)
Query: 219 LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI-- 276
L A E A+K L + A + + ++ + S AE A AA
Sbjct: 2036 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2095
Query: 277 CKVLAVNQ--ENEKLMEEYEKL-------------ASELLEWIRRTVPWLENRVGEPSMS 321
+V A + ++ + +EE E+L A E +R+ R + +
Sbjct: 2096 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2155
Query: 322 AMQRKLEDFRDYRRLHK--PPRIQEKCQLEINFNTLQTKLR-LSHRPAFMPSE-GKLVSD 377
A+++K + + K +++K Q+E TL+ +L H+ + E +L ++
Sbjct: 2156 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2215
Query: 378 IANAWRGLEQVEKGY---------------------EDWLLSEIRRLQR-LQHLAEKFRQ 415
A R QVE+ +L + QR LQ AEK +Q
Sbjct: 2216 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2275
Query: 416 KASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL 475
A + +E R L + RAL + + R++ A L Q+
Sbjct: 2276 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2335
Query: 476 NELDYHEAASVNSRCQAICDQW--DNLG---TLTQKRRDAL------ERMEKLLETIDQL 524
EL +A + + + Q + G TL +R+ L ER++ + + +
Sbjct: 2336 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2395
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Q A F + E L L + E+ + T Q + + +A+R R AI
Sbjct: 2396 QARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2454
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK-LVPSRDQTLQEELARQQVNE 643
++ E +K+ Q L + T+ + + + +++ + +D LQ E +Q
Sbjct: 2455 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2514
Query: 644 RLRRQF---AAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+L + F A+A + Q + +++ + L S+EE + E+ + + +
Sbjct: 2515 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2574
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQV 749
+LE + +E L +N+ E +++ EQ ++A + +QV
Sbjct: 2575 QLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2620
Score = 40.0 bits (92), Expect = 0.010
Identities = 95/511 (18%), Positives = 200/511 (39%), Gaps = 32/511 (6%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRK 326
E+AE A + + +E E+ +E ++ A+E L +R + + A ++K
Sbjct: 1608 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1666
Query: 327 LEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAF--MPSEGKLVSDIANAWRG 384
E R+ RR K Q Q E+ L+ + +L+ A + +E +L+ A +G
Sbjct: 1667 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1725
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML-----SQRDYDSA 439
+Q L E+ RLQR A + RQ+ A R + E+L + +
Sbjct: 1726 EQQ-----RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1780
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI-CDQWD 498
++ + L +LA R+ +A A+ +L +AA + + + ++
Sbjct: 1781 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1840
Query: 499 NLGTLTQKRRDA---LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSV 555
+G T+ + +A L+ E E + +L + A + D+++
Sbjct: 1841 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1900
Query: 556 EETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDIN 615
L + TL + + I+ ++ +K + + +
Sbjct: 1901 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1960
Query: 616 TKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLA 675
+K + R +EE R++ ER+++ AA+ A +A +EEV RL A +
Sbjct: 1961 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKV- 2018
Query: 676 GSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
E+ LR++ + + + +L+ + Q+ L + K ++++ +Q L
Sbjct: 2019 ----EEARRLRERAE-----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2069
Query: 736 TSIARTINEVENQVLTRDAKGLSQEQLNEFR 766
++++ + +A + E+ E R
Sbjct: 2070 QQEQSVLDQLRGEA---EAARRAAEEAEEAR 2097
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 248 bits (634), Expect = 1e-65
Identities = 202/636 (31%), Positives = 302/636 (47%), Gaps = 51/636 (8%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
++ Q+KTFT W N HL KA I ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFHK
Sbjct: 45 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 103
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 104 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 163
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW QR Y+ + NF +SW+DG A+IHRH+P LID K+ + + NL
Sbjct: 164 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 223
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
+ AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS Y A +
Sbjct: 224 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 278
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
E + +EY +L LL+W+R E R S ++ F ++ + P
Sbjct: 279 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 334
Query: 340 PRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
+ +K + + + +L+ + +L P + P D+ W L E L
Sbjct: 335 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 388
Query: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQ-EVRALL-----RR 450
SE RL+ LQ + K + +A L EE L+Q D ALLQ +VR L +R
Sbjct: 389 RSEFERLECLQRIVTKLQMEAGL-------CEEQLNQAD---ALLQSDVRLLAAGKVPQR 438
Query: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
E DL + + Q L + + + + R + ++ + T R A
Sbjct: 439 AGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 498
Query: 511 LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA 570
+ + Q+ L+ +R D + LQD L+ VEE Q + ++
Sbjct: 499 --GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGV 550
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
LP + + G+ G+ I++ LSP D + +L +
Sbjct: 551 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---QLSPATRGAYRDCLGRLDLQYAK 607
Query: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
L AR + E L F A A W+ K EE
Sbjct: 608 LLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 642
Score = 44.7 bits (104), Expect = 4e-04
Identities = 116/589 (19%), Positives = 224/589 (38%), Gaps = 62/589 (10%)
Query: 219 LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI-- 276
L A E A+K L + A + + ++ + S AE A AA
Sbjct: 2040 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2099
Query: 277 CKVLAVNQ--ENEKLMEEYEKL-------------ASELLEWIRRTVPWLENRVGEPSMS 321
+V A + ++ + +EE E+L A E +R+ R + +
Sbjct: 2100 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2159
Query: 322 AMQRKLEDFRDYRRLHK--PPRIQEKCQLEINFNTLQTKLR-LSHRPAFMPSE-GKLVSD 377
A+++K + + K +++K Q+E TL+ +L H+ + E +L ++
Sbjct: 2160 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2219
Query: 378 IANAWRGLEQVEKGY---------------------EDWLLSEIRRLQR-LQHLAEKFRQ 415
A R QVE+ +L + QR LQ AEK +Q
Sbjct: 2220 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2279
Query: 416 KASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL 475
A + +E R L + RAL + + R++ A L Q+
Sbjct: 2280 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2339
Query: 476 NELDYHEAASVNSRCQAICDQW--DNLG---TLTQKRRDAL------ERMEKLLETIDQL 524
EL +A + + + Q + G TL +R+ L ER++ + + +
Sbjct: 2340 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2399
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Q A F + E L L + E+ + T Q + + +A+R R AI
Sbjct: 2400 QARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2458
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK-LVPSRDQTLQEELARQQVNE 643
++ E +K+ Q L + T+ + + + +++ + +D LQ E +Q
Sbjct: 2459 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2518
Query: 644 RLRRQF---AAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+L + F A+A + Q + +++ + L S+EE + E+ + + +
Sbjct: 2519 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2578
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQV 749
+LE + +E L +N+ E +++ EQ ++A + +QV
Sbjct: 2579 QLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2624
Score = 40.0 bits (92), Expect = 0.010
Identities = 95/511 (18%), Positives = 200/511 (39%), Gaps = 32/511 (6%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRK 326
E+AE A + + +E E+ +E ++ A+E L +R + + A ++K
Sbjct: 1612 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1670
Query: 327 LEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAF--MPSEGKLVSDIANAWRG 384
E R+ RR K Q Q E+ L+ + +L+ A + +E +L+ A +G
Sbjct: 1671 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1729
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML-----SQRDYDSA 439
+Q L E+ RLQR A + RQ+ A R + E+L + +
Sbjct: 1730 EQQ-----RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1784
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI-CDQWD 498
++ + L +LA R+ +A A+ +L +AA + + + ++
Sbjct: 1785 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1844
Query: 499 NLGTLTQKRRDA---LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSV 555
+G T+ + +A L+ E E + +L + A + D+++
Sbjct: 1845 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1904
Query: 556 EETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDIN 615
L + TL + + I+ ++ +K + + +
Sbjct: 1905 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1964
Query: 616 TKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLA 675
+K + R +EE R++ ER+++ AA+ A +A +EEV RL A +
Sbjct: 1965 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKV- 2022
Query: 676 GSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
E+ LR++ + + + +L+ + Q+ L + K ++++ +Q L
Sbjct: 2023 ----EEARRLRERAE-----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2073
Query: 736 TSIARTINEVENQVLTRDAKGLSQEQLNEFR 766
++++ + +A + E+ E R
Sbjct: 2074 QQEQSVLDQLRGEA---EAARRAAEEAEEAR 2101
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 248 bits (634), Expect = 1e-65
Identities = 202/636 (31%), Positives = 302/636 (47%), Gaps = 51/636 (8%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
++ Q+KTFT W N HL KA I ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFHK
Sbjct: 9 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 67
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 68 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 127
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW QR Y+ + NF +SW+DG A+IHRH+P LID K+ + + NL
Sbjct: 128 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 187
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
+ AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS Y A +
Sbjct: 188 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 242
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
E + +EY +L LL+W+R E R S ++ F ++ + P
Sbjct: 243 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 298
Query: 340 PRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
+ +K + + + +L+ + +L P + P D+ W L E L
Sbjct: 299 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 352
Query: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQ-EVRALL-----RR 450
SE RL+ LQ + K + +A L EE L+Q D ALLQ +VR L +R
Sbjct: 353 RSEFERLECLQRIVTKLQMEAGL-------CEEQLNQAD---ALLQSDVRLLAAGKVPQR 402
Query: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
E DL + + Q L + + + + R + ++ + T R A
Sbjct: 403 AGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 462
Query: 511 LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA 570
+ + Q+ L+ +R D + LQD L+ VEE Q + ++
Sbjct: 463 --GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGV 514
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
LP + + G+ G+ I++ LSP D + +L +
Sbjct: 515 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---QLSPATRGAYRDCLGRLDLQYAK 571
Query: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
L AR + E L F A A W+ K EE
Sbjct: 572 LLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 606
Score = 44.7 bits (104), Expect = 4e-04
Identities = 116/589 (19%), Positives = 224/589 (38%), Gaps = 62/589 (10%)
Query: 219 LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI-- 276
L A E A+K L + A + + ++ + S AE A AA
Sbjct: 2004 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2063
Query: 277 CKVLAVNQ--ENEKLMEEYEKL-------------ASELLEWIRRTVPWLENRVGEPSMS 321
+V A + ++ + +EE E+L A E +R+ R + +
Sbjct: 2064 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2123
Query: 322 AMQRKLEDFRDYRRLHK--PPRIQEKCQLEINFNTLQTKLR-LSHRPAFMPSE-GKLVSD 377
A+++K + + K +++K Q+E TL+ +L H+ + E +L ++
Sbjct: 2124 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2183
Query: 378 IANAWRGLEQVEKGY---------------------EDWLLSEIRRLQR-LQHLAEKFRQ 415
A R QVE+ +L + QR LQ AEK +Q
Sbjct: 2184 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2243
Query: 416 KASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL 475
A + +E R L + RAL + + R++ A L Q+
Sbjct: 2244 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2303
Query: 476 NELDYHEAASVNSRCQAICDQW--DNLG---TLTQKRRDAL------ERMEKLLETIDQL 524
EL +A + + + Q + G TL +R+ L ER++ + + +
Sbjct: 2304 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2363
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Q A F + E L L + E+ + T Q + + +A+R R AI
Sbjct: 2364 QARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2422
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK-LVPSRDQTLQEELARQQVNE 643
++ E +K+ Q L + T+ + + + +++ + +D LQ E +Q
Sbjct: 2423 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2482
Query: 644 RLRRQF---AAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+L + F A+A + Q + +++ + L S+EE + E+ + + +
Sbjct: 2483 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2542
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQV 749
+LE + +E L +N+ E +++ EQ ++A + +QV
Sbjct: 2543 QLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2588
Score = 40.0 bits (92), Expect = 0.010
Identities = 95/511 (18%), Positives = 200/511 (39%), Gaps = 32/511 (6%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRK 326
E+AE A + + +E E+ +E ++ A+E L +R + + A ++K
Sbjct: 1576 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1634
Query: 327 LEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAF--MPSEGKLVSDIANAWRG 384
E R+ RR K Q Q E+ L+ + +L+ A + +E +L+ A +G
Sbjct: 1635 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1693
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML-----SQRDYDSA 439
+Q L E+ RLQR A + RQ+ A R + E+L + +
Sbjct: 1694 EQQ-----RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1748
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI-CDQWD 498
++ + L +LA R+ +A A+ +L +AA + + + ++
Sbjct: 1749 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1808
Query: 499 NLGTLTQKRRDA---LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSV 555
+G T+ + +A L+ E E + +L + A + D+++
Sbjct: 1809 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1868
Query: 556 EETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDIN 615
L + TL + + I+ ++ +K + + +
Sbjct: 1869 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1928
Query: 616 TKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLA 675
+K + R +EE R++ ER+++ AA+ A +A +EEV RL A +
Sbjct: 1929 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKV- 1986
Query: 676 GSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
E+ LR++ + + + +L+ + Q+ L + K ++++ +Q L
Sbjct: 1987 ----EEARRLRERAE-----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2037
Query: 736 TSIARTINEVENQVLTRDAKGLSQEQLNEFR 766
++++ + +A + E+ E R
Sbjct: 2038 QQEQSVLDQLRGEA---EAARRAAEEAEEAR 2065
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 248 bits (634), Expect = 1e-65
Identities = 202/636 (31%), Positives = 302/636 (47%), Gaps = 51/636 (8%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
++ Q+KTFT W N HL KA I ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFHK
Sbjct: 178 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 236
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 237 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 296
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW QR Y+ + NF +SW+DG A+IHRH+P LID K+ + + NL
Sbjct: 297 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 356
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
+ AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS Y A +
Sbjct: 357 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 411
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
E + +EY +L LL+W+R E R S ++ F ++ + P
Sbjct: 412 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 467
Query: 340 PRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
+ +K + + + +L+ + +L P + P D+ W L E L
Sbjct: 468 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 521
Query: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQ-EVRALL-----RR 450
SE RL+ LQ + K + +A L EE L+Q D ALLQ +VR L +R
Sbjct: 522 RSEFERLECLQRIVTKLQMEAGL-------CEEQLNQAD---ALLQSDVRLLAAGKVPQR 571
Query: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
E DL + + Q L + + + + R + ++ + T R A
Sbjct: 572 AGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 631
Query: 511 LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA 570
+ + Q+ L+ +R D + LQD L+ VEE Q + ++
Sbjct: 632 --GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGV 683
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
LP + + G+ G+ I++ LSP D + +L +
Sbjct: 684 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---QLSPATRGAYRDCLGRLDLQYAK 740
Query: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
L AR + E L F A A W+ K EE
Sbjct: 741 LLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 775
Score = 44.7 bits (104), Expect = 4e-04
Identities = 116/589 (19%), Positives = 224/589 (38%), Gaps = 62/589 (10%)
Query: 219 LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI-- 276
L A E A+K L + A + + ++ + S AE A AA
Sbjct: 2173 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232
Query: 277 CKVLAVNQ--ENEKLMEEYEKL-------------ASELLEWIRRTVPWLENRVGEPSMS 321
+V A + ++ + +EE E+L A E +R+ R + +
Sbjct: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2292
Query: 322 AMQRKLEDFRDYRRLHK--PPRIQEKCQLEINFNTLQTKLR-LSHRPAFMPSE-GKLVSD 377
A+++K + + K +++K Q+E TL+ +L H+ + E +L ++
Sbjct: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352
Query: 378 IANAWRGLEQVEKGY---------------------EDWLLSEIRRLQR-LQHLAEKFRQ 415
A R QVE+ +L + QR LQ AEK +Q
Sbjct: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412
Query: 416 KASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL 475
A + +E R L + RAL + + R++ A L Q+
Sbjct: 2413 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472
Query: 476 NELDYHEAASVNSRCQAICDQW--DNLG---TLTQKRRDAL------ERMEKLLETIDQL 524
EL +A + + + Q + G TL +R+ L ER++ + + +
Sbjct: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Q A F + E L L + E+ + T Q + + +A+R R AI
Sbjct: 2533 QARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2591
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK-LVPSRDQTLQEELARQQVNE 643
++ E +K+ Q L + T+ + + + +++ + +D LQ E +Q
Sbjct: 2592 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2651
Query: 644 RLRRQF---AAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+L + F A+A + Q + +++ + L S+EE + E+ + + +
Sbjct: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQV 749
+LE + +E L +N+ E +++ EQ ++A + +QV
Sbjct: 2712 QLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2757
Score = 40.0 bits (92), Expect = 0.010
Identities = 95/511 (18%), Positives = 200/511 (39%), Gaps = 32/511 (6%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRK 326
E+AE A + + +E E+ +E ++ A+E L +R + + A ++K
Sbjct: 1745 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1803
Query: 327 LEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAF--MPSEGKLVSDIANAWRG 384
E R+ RR K Q Q E+ L+ + +L+ A + +E +L+ A +G
Sbjct: 1804 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML-----SQRDYDSA 439
+Q L E+ RLQR A + RQ+ A R + E+L + +
Sbjct: 1863 EQQ-----RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1917
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI-CDQWD 498
++ + L +LA R+ +A A+ +L +AA + + + ++
Sbjct: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977
Query: 499 NLGTLTQKRRDA---LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSV 555
+G T+ + +A L+ E E + +L + A + D+++
Sbjct: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037
Query: 556 EETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDIN 615
L + TL + + I+ ++ +K + + +
Sbjct: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097
Query: 616 TKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLA 675
+K + R +EE R++ ER+++ AA+ A +A +EEV RL A +
Sbjct: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKV- 2155
Query: 676 GSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
E+ LR++ + + + +L+ + Q+ L + K ++++ +Q L
Sbjct: 2156 ----EEARRLRERAE-----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2206
Query: 736 TSIARTINEVENQVLTRDAKGLSQEQLNEFR 766
++++ + +A + E+ E R
Sbjct: 2207 QQEQSVLDQLRGEA---EAARRAAEEAEEAR 2234
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 248 bits (634), Expect = 1e-65
Identities = 202/636 (31%), Positives = 302/636 (47%), Gaps = 51/636 (8%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
++ Q+KTFT W N HL KA I ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFHK
Sbjct: 19 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 77
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 78 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 137
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW QR Y+ + NF +SW+DG A+IHRH+P LID K+ + + NL
Sbjct: 138 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 197
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
+ AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS Y A +
Sbjct: 198 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 252
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
E + +EY +L LL+W+R E R S ++ F ++ + P
Sbjct: 253 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 308
Query: 340 PRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
+ +K + + + +L+ + +L P + P D+ W L E L
Sbjct: 309 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 362
Query: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQ-EVRALL-----RR 450
SE RL+ LQ + K + +A L EE L+Q D ALLQ +VR L +R
Sbjct: 363 RSEFERLECLQRIVTKLQMEAGL-------CEEQLNQAD---ALLQSDVRLLAAGKVPQR 412
Query: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
E DL + + Q L + + + + R + ++ + T R A
Sbjct: 413 AGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 472
Query: 511 LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA 570
+ + Q+ L+ +R D + LQD L+ VEE Q + ++
Sbjct: 473 --GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGV 524
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
LP + + G+ G+ I++ LSP D + +L +
Sbjct: 525 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---QLSPATRGAYRDCLGRLDLQYAK 581
Query: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
L AR + E L F A A W+ K EE
Sbjct: 582 LLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 616
Score = 44.7 bits (104), Expect = 4e-04
Identities = 116/589 (19%), Positives = 224/589 (38%), Gaps = 62/589 (10%)
Query: 219 LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI-- 276
L A E A+K L + A + + ++ + S AE A AA
Sbjct: 2014 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
Query: 277 CKVLAVNQ--ENEKLMEEYEKL-------------ASELLEWIRRTVPWLENRVGEPSMS 321
+V A + ++ + +EE E+L A E +R+ R + +
Sbjct: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2133
Query: 322 AMQRKLEDFRDYRRLHK--PPRIQEKCQLEINFNTLQTKLR-LSHRPAFMPSE-GKLVSD 377
A+++K + + K +++K Q+E TL+ +L H+ + E +L ++
Sbjct: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193
Query: 378 IANAWRGLEQVEKGY---------------------EDWLLSEIRRLQR-LQHLAEKFRQ 415
A R QVE+ +L + QR LQ AEK +Q
Sbjct: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253
Query: 416 KASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL 475
A + +E R L + RAL + + R++ A L Q+
Sbjct: 2254 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
Query: 476 NELDYHEAASVNSRCQAICDQW--DNLG---TLTQKRRDAL------ERMEKLLETIDQL 524
EL +A + + + Q + G TL +R+ L ER++ + + +
Sbjct: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2373
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Q A F + E L L + E+ + T Q + + +A+R R AI
Sbjct: 2374 QARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2432
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK-LVPSRDQTLQEELARQQVNE 643
++ E +K+ Q L + T+ + + + +++ + +D LQ E +Q
Sbjct: 2433 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2492
Query: 644 RLRRQF---AAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+L + F A+A + Q + +++ + L S+EE + E+ + + +
Sbjct: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQV 749
+LE + +E L +N+ E +++ EQ ++A + +QV
Sbjct: 2553 QLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2598
Score = 40.0 bits (92), Expect = 0.010
Identities = 95/511 (18%), Positives = 200/511 (39%), Gaps = 32/511 (6%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRK 326
E+AE A + + +E E+ +E ++ A+E L +R + + A ++K
Sbjct: 1586 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1644
Query: 327 LEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAF--MPSEGKLVSDIANAWRG 384
E R+ RR K Q Q E+ L+ + +L+ A + +E +L+ A +G
Sbjct: 1645 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML-----SQRDYDSA 439
+Q L E+ RLQR A + RQ+ A R + E+L + +
Sbjct: 1704 EQQ-----RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1758
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI-CDQWD 498
++ + L +LA R+ +A A+ +L +AA + + + ++
Sbjct: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
Query: 499 NLGTLTQKRRDA---LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSV 555
+G T+ + +A L+ E E + +L + A + D+++
Sbjct: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
Query: 556 EETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDIN 615
L + TL + + I+ ++ +K + + +
Sbjct: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938
Query: 616 TKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLA 675
+K + R +EE R++ ER+++ AA+ A +A +EEV RL A +
Sbjct: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKV- 1996
Query: 676 GSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
E+ LR++ + + + +L+ + Q+ L + K ++++ +Q L
Sbjct: 1997 ----EEARRLRERAE-----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2047
Query: 736 TSIARTINEVENQVLTRDAKGLSQEQLNEFR 766
++++ + +A + E+ E R
Sbjct: 2048 QQEQSVLDQLRGEA---EAARRAAEEAEEAR 2075
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 248 bits (634), Expect = 1e-65
Identities = 202/636 (31%), Positives = 302/636 (47%), Gaps = 51/636 (8%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
++ Q+KTFT W N HL KA I ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFHK
Sbjct: 27 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 85
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 86 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 145
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW QR Y+ + NF +SW+DG A+IHRH+P LID K+ + + NL
Sbjct: 146 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 205
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
+ AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS Y A +
Sbjct: 206 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 260
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
E + +EY +L LL+W+R E R S ++ F ++ + P
Sbjct: 261 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 316
Query: 340 PRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
+ +K + + + +L+ + +L P + P D+ W L E L
Sbjct: 317 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 370
Query: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQ-EVRALL-----RR 450
SE RL+ LQ + K + +A L EE L+Q D ALLQ +VR L +R
Sbjct: 371 RSEFERLECLQRIVTKLQMEAGL-------CEEQLNQAD---ALLQSDVRLLAAGKVPQR 420
Query: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
E DL + + Q L + + + + R + ++ + T R A
Sbjct: 421 AGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 480
Query: 511 LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA 570
+ + Q+ L+ +R D + LQD L+ VEE Q + ++
Sbjct: 481 --GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGV 532
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
LP + + G+ G+ I++ LSP D + +L +
Sbjct: 533 DLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEG---QLSPATRGAYRDCLGRLDLQYAK 589
Query: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
L AR + E L F A A W+ K EE
Sbjct: 590 LLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 624
Score = 44.7 bits (104), Expect = 4e-04
Identities = 116/589 (19%), Positives = 224/589 (38%), Gaps = 62/589 (10%)
Query: 219 LNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRI-- 276
L A E A+K L + A + + ++ + S AE A AA
Sbjct: 2022 LQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2081
Query: 277 CKVLAVNQ--ENEKLMEEYEKL-------------ASELLEWIRRTVPWLENRVGEPSMS 321
+V A + ++ + +EE E+L A E +R+ R + +
Sbjct: 2082 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA 2141
Query: 322 AMQRKLEDFRDYRRLHK--PPRIQEKCQLEINFNTLQTKLR-LSHRPAFMPSE-GKLVSD 377
A+++K + + K +++K Q+E TL+ +L H+ + E +L ++
Sbjct: 2142 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2201
Query: 378 IANAWRGLEQVEKGY---------------------EDWLLSEIRRLQR-LQHLAEKFRQ 415
A R QVE+ +L + QR LQ AEK +Q
Sbjct: 2202 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2261
Query: 416 KASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL 475
A + +E R L + RAL + + R++ A L Q+
Sbjct: 2262 VAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2321
Query: 476 NELDYHEAASVNSRCQAICDQW--DNLG---TLTQKRRDAL------ERMEKLLETIDQL 524
EL +A + + + Q + G TL +R+ L ER++ + + +
Sbjct: 2322 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2381
Query: 525 QLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMG 584
Q A F + E L L + E+ + T Q + + +A+R R AI
Sbjct: 2382 QARAEEDAQRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2440
Query: 585 IQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRK-LVPSRDQTLQEELARQQVNE 643
++ E +K+ Q L + T+ + + + +++ + +D LQ E +Q
Sbjct: 2441 LEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKA 2500
Query: 644 RLRRQF---AAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+L + F A+A + Q + +++ + L S+EE + E+ + + +
Sbjct: 2501 KLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2560
Query: 701 RLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQV 749
+LE + +E L +N+ E +++ EQ ++A + +QV
Sbjct: 2561 QLEQQRRQQEELLAEENQRL---REQLQLLEEQHRAALAHSEEVTASQV 2606
Score = 40.0 bits (92), Expect = 0.010
Identities = 95/511 (18%), Positives = 200/511 (39%), Gaps = 32/511 (6%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRK 326
E+AE A + + +E E+ +E ++ A+E L +R + + A ++K
Sbjct: 1594 EEAERRAQQQAEAERAREEAERELERWQLKANEALR-LRLQAEEVAQQKSLAQAEAEKQK 1652
Query: 327 LEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAF--MPSEGKLVSDIANAWRG 384
E R+ RR K Q Q E+ L+ + +L+ A + +E +L+ A +G
Sbjct: 1653 EEAEREARRRGKAEE-QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1711
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEML-----SQRDYDSA 439
+Q L E+ RLQR A + RQ+ A R + E+L + +
Sbjct: 1712 EQQ-----RQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1766
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAI-CDQWD 498
++ + L +LA R+ +A A+ +L +AA + + + ++
Sbjct: 1767 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1826
Query: 499 NLGTLTQKRRDA---LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSV 555
+G T+ + +A L+ E E + +L + A + D+++
Sbjct: 1827 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1886
Query: 556 EETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDIN 615
L + TL + + I+ ++ +K + + +
Sbjct: 1887 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1946
Query: 616 TKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLA 675
+K + R +EE R++ ER+++ AA+ A +A +EEV RL A +
Sbjct: 1947 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA-ARQRKAALEEVERLKAKV- 2004
Query: 676 GSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLL 735
E+ LR++ + + + +L+ + Q+ L + K ++++ +Q L
Sbjct: 2005 ----EEARRLRERAE-----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTL 2055
Query: 736 TSIARTINEVENQVLTRDAKGLSQEQLNEFR 766
++++ + +A + E+ E R
Sbjct: 2056 QQEQSVLDQLRGEA---EAARRAAEEAEEAR 2083
>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo
sapiens]
Length = 1369
Score = 245 bits (625), Expect = 2e-64
Identities = 203/636 (31%), Positives = 301/636 (47%), Gaps = 51/636 (8%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
++ Q+KT T W N HL KA I ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFHK
Sbjct: 174 DRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHK 232
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ +
Sbjct: 233 LQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMT 292
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW QR Y+ + NF +SW+DG A+IHRH+P LID K+ + + NL
Sbjct: 293 AKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENL 352
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
+ AF VAE+ L + ++LD ED V+ P+PDEK+I+TYVS Y A +
Sbjct: 353 DQAFSVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRA---- 407
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
E + +EY +L LL+W+R E R S ++ F ++ + P
Sbjct: 408 ----NELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELP 463
Query: 340 PRIQEKCQLEINFNTLQTKL---RLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWL 396
+ +K + + + +L+ + +L P + P D+ W L E L
Sbjct: 464 AKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHP------LDVEKEWGKLHVAILEREKQL 517
Query: 397 LSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALL------RR 450
SE RL+ LQ + K + +A L EE L Q D ALLQ LL +R
Sbjct: 518 RSEFERLECLQRIVTKLQMEAGL-------CEEQLHQAD---ALLQSDIRLLAAGKVPQR 567
Query: 451 HEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDA 510
E DL + + Q L + + + + R + ++ + T R A
Sbjct: 568 AGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKA 627
Query: 511 LERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKA 570
+ + Q+ L+ +R D + LQD L+ VEE Q + ++
Sbjct: 628 --GVAAPATQVAQVTLQSVQRRPELE---DSTLRYLQD--LLAWVEENQHRVDG-AEWGV 679
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
LP + + G+ G+ I++ Q R S LSP D + +L +
Sbjct: 680 DLPSVEAQLGSHRGLHQSIEEF-QAKIERARSDEG--QLSPATRGAYRDCLGRLDLQYAK 736
Query: 631 TLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
L AR + E L F A A W+ K EE
Sbjct: 737 LLNSSKARLRSLESL-HSFVAAATKELMWLNEKEEE 771
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 236 bits (602), Expect = 7e-62
Identities = 140/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
+K Q+KTFT W N HL K + ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFH+
Sbjct: 63 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 121
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 122 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 181
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW Q+ T Y + +NF T W+DG A+IH++RPDLID + + NL
Sbjct: 182 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 241
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
AF VAEK + + ++LD ED V+ PDEK+++TYVS Y AF +
Sbjct: 242 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 292
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
+ N K + EY+ + + L++WIR V + R + ++ + ++ P
Sbjct: 293 IGANDVEVKWI-EYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 351
Query: 340 PRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSE 399
P+ EK +++ + L+ + +G +DI W L E L E
Sbjct: 352 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 408
Query: 400 IRRLQRLQHLAEKFRQKASLHE 421
+ RL+ LQ +A + ++ + + E
Sbjct: 409 VERLEMLQQIANRVQRDSVICE 430
Score = 53.5 bits (127), Expect = 9e-07
Identities = 113/570 (19%), Positives = 217/570 (38%), Gaps = 83/570 (14%)
Query: 234 KMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLA-------VNQEN 286
++L +DI++ IMT S E+ ++ ++ KVL +N E
Sbjct: 3820 EILRHKDIIDDLVKSGHKIMTACS--------EEEKQSMKKKLDKVLKNYDTICQINSER 3871
Query: 287 EKLMEEYEKLASELLEWIRRTVPWL-ENRVGEPSMSAMQRKLEDFRDYRRLHKPPR---I 342
+E + L ++ E PWL E + + A + E R + H+ R
Sbjct: 3872 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3931
Query: 343 QEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRR 402
+ K ++ T L LS P EG + + A D L S+I+
Sbjct: 3932 EHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVA-----------ADTLYSQIKE 3974
Query: 403 --LQRLQHLAEKFRQKASLHEAWTRGKE------EMLSQRDYDSALLQEVRALLRRHEAF 454
+R L E Q H+ + E E L Q SA +++++ + ++
Sbjct: 3975 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 4034
Query: 455 ESDLAAHQDRVEHIAALAQEL------NELDYHEAASVNSRCQAICDQWDNLGTLTQKRR 508
D+ Q E + +E+ + D A +V + + W+N+ TL ++R
Sbjct: 4035 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDI-SAKAVQDKLDQMVFIWENIHTLVEERE 4093
Query: 509 DALERMEKLLETI--DQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHD 566
L + +L E D + L + + DL+D + SV + Q A +
Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDT------QDFIRDLEDPGIDPSVVKQQQ--EAAE 4145
Query: 567 QFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVP 626
+ + E ++ + E+ C P + S ++N+ WD + K
Sbjct: 4146 TIREEIDGLQEELDIVINLGSELIAACGE------PDKPIVKKSIDELNSAWDSLNKAWK 4199
Query: 627 SRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQ---AKVEEVGRLAAGLAGSLEEQMA 683
R L+E + + Q+ A+ W+ K+ + + L ++++Q+
Sbjct: 4200 DRIDKLEEAM-------QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE-TVKQQIE 4251
Query: 684 GLRQQEQNIINYKTNIDRLEGDHQLLQESLVFD-NKHTVYS-MEHIRVGWEQLLTSIART 741
L+Q + + ++RL +LL + + + +KHTV + +++ W+ L I
Sbjct: 4252 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINR 4311
Query: 742 INEVENQVLTRDAKGLSQEQLNEFRASFNH 771
+++E +L A G Q L+E A H
Sbjct: 4312 QHKLEGALL---ALGQFQHALDELLAWLTH 4338
Score = 50.4 bits (119), Expect = 7e-06
Identities = 77/366 (21%), Positives = 136/366 (37%), Gaps = 52/366 (14%)
Query: 290 MEEYEKLASELLEWIRRTVPWLENRVGE-PSMSAMQRKLEDFRDYRRLHKPPRIQEKCQL 348
+EE + A + + ++ W++ G+ SMS + LE + K + E Q
Sbjct: 4205 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK-SEAYQQ 4263
Query: 349 EINFNTLQTKLRLSHRPAFMPSEGKLVSD----IANAWRGLEQVEKGYEDWLLSEIRRLQ 404
+I L + L + S+ V D + W LE+ + L + L
Sbjct: 4264 QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG 4323
Query: 405 RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
+ QH ++ AW E +LS++ + + L +H ++D+ AHQ
Sbjct: 4324 QFQHALDELL-------AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4376
Query: 465 VEHIAALAQELNELDY-HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQ 523
VE + +L E EA+++ ++ + + +W N+ T++R+
Sbjct: 4377 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQ-------------- 4422
Query: 524 LQLEFARRAAPFNNWLDGAVEDLQDVWLVHS-------------VEETQSLLTAHDQFKA 570
QL+ A R A G +EDLQ WL + E + L H + A
Sbjct: 4423 -QLDGALRQA---KGFHGEIEDLQQ-WLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4477
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
+ ++M QK Q P S I ++ KW+ V + R
Sbjct: 4478 AFEAKEETYKSLM------QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4531
Query: 631 TLQEEL 636
L+E L
Sbjct: 4532 KLEEAL 4537
Score = 48.1 bits (113), Expect = 4e-05
Identities = 63/314 (20%), Positives = 131/314 (41%), Gaps = 25/314 (7%)
Query: 344 EKCQLEINFNTLQTKLR--LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIR 401
+K + EI Q K+ L + + E L ++++ G+ + K E + ++
Sbjct: 2723 QKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQ 2782
Query: 402 RLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
LQ + +F+Q + +AW K+E ++ SA L + +L++ H+ F L A
Sbjct: 2783 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ 2842
Query: 462 QDRVEHIAALAQE-LNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDAL-ERMEKLLE 519
E A + L + E A++ + I WD ++R + L E +EK L+
Sbjct: 2843 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2902
Query: 520 TIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRER 579
+Q++ + W+D +L+++ E ++ + + K+ E D+
Sbjct: 2903 YKEQVETLWP--------WIDKCQNNLEEIKFCLDPAEGENSIA---KLKSLQKEMDQHF 2951
Query: 580 GAIMGIQGEIQKICQTYGLRPCSTN-PYITLSPQDINTKWDMVRKLVPSRDQTLQEELAR 638
G + + + L C + +T + + K DMV + + S+ L+ +
Sbjct: 2952 GMVELLNNTANSL-----LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 3006
Query: 639 ----QQVNERLRRQ 648
Q+V++ +RQ
Sbjct: 3007 FKEFQEVSKESKRQ 3020
Score = 40.0 bits (92), Expect = 0.010
Identities = 82/423 (19%), Positives = 159/423 (37%), Gaps = 52/423 (12%)
Query: 383 RGLEQVEKGYEDWLLSEIRRLQ---RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSA 439
+ +++++ YE L ++++ LQ EKF + E W + E+ L + +
Sbjct: 1838 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1897
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDN 499
+ + L+R ++F D+ +H+ + +I + E A S + R D
Sbjct: 1898 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLE----AAKSCSKRDGGKVDTSAT 1953
Query: 500 LGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD---GAVEDLQDVWLVHSVE 556
+ +K A +R L + L + ++ D G + LQ S
Sbjct: 1954 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2013
Query: 557 ETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTY--------GLRPCSTNPYIT 608
++ + + L E +G I Q ++K+ +T L P + T
Sbjct: 2014 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2073
Query: 609 LSPQDINTKWDMVRKLVPSRDQTLQEELARQ-QVNERLRRQFAAQANAIGPWIQAKVEEV 667
L DI +++ + K V R++ LQ L R V + L N +++ ++E
Sbjct: 2074 L--DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN-----VESSLKEQ 2126
Query: 668 GRLAAGLAG---------SLEEQMAGLRQQEQNIINYK-------------TNIDRLEGD 705
G++ LE+ +AG RQ N +N K +++ D
Sbjct: 2127 GQVPLNSTALQDIISKNIMLEQDIAG-RQSSINAMNEKVKKFMETTDPSTASSLQAKMKD 2185
Query: 706 HQLLQESLVFDNKHTVYSMEHIRVGWE--QLLTSIARTINEVENQVLTR-DAKGLSQEQL 762
+K T+ ME ++ E + L+ +T E + Q LT D G +L
Sbjct: 2186 LSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2245
Query: 763 NEF 765
+++
Sbjct: 2246 SQY 2248
Score = 38.1 bits (87), Expect = 0.037
Identities = 68/305 (22%), Positives = 112/305 (36%), Gaps = 35/305 (11%)
Query: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYED---WLLSEIRRLQ-RLQHLAEKFRQK 416
+ + AF GK S + R ++ +G D W+ +++ L R + + K
Sbjct: 4797 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4856
Query: 417 ASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELN 476
+ EA R EE S L E LR H D A + ++ ++L
Sbjct: 4857 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4916
Query: 477 E--LDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAA- 533
E + ++A ++ AIC D++ T+ R E++L Q Q A A
Sbjct: 4917 EKRAELNKATTMGDTVLAICHP-DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4975
Query: 534 ------------PFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
+ W + + D + +EE ++L+ H F + E R+
Sbjct: 4976 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTF---MEEMTRK--- 5029
Query: 582 IMGIQGEIQKICQTYGLR---PCSTNPYI-TLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
Q ++ K+ +TY R P S +I L K L PS QT Q E
Sbjct: 5030 ----QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQT-QIETK 5084
Query: 638 RQQVN 642
+VN
Sbjct: 5085 NPRVN 5089
Score = 34.3 bits (77), Expect = 0.54
Identities = 99/572 (17%), Positives = 216/572 (37%), Gaps = 80/572 (13%)
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
NT E+ ++ + LD+ V + + F + AN+ CK+
Sbjct: 3121 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3180
Query: 280 LAVNQENEK----LMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDF----R 331
+ +E + + E L+ + + + R + E + ++LE+F +
Sbjct: 3181 MLATEETSPDLVGIKRDLEALSKQCNKLLDRA------QAREEQVEGTIKRLEEFYSKLK 3234
Query: 332 DYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFM-----PSEGKLVSDIANAWRGLE 386
++ L + E+ Q + T +L+ F P +GK D+ +GL
Sbjct: 3235 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ-QDVNWLGQGLI 3293
Query: 387 Q----------VEKGYED----WLLSEIRRLQRLQHLAE------KFRQKASLHEAWTRG 426
Q +E +D W + QR L E +F+ +W
Sbjct: 3294 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3353
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL-NELDYHEAAS 485
EE+++ + SA + V+A ++ + + L + VE I +++ + +
Sbjct: 3354 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK 3413
Query: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVED 545
+ + + +W+ L + R + LE I + +F P N WL +
Sbjct: 3414 ILKQLSLLDSRWEALLNKAETRN-------RQLEGISVVAQQFHETLEPLNEWLTTIEKR 3466
Query: 546 LQDVWLVHS-VEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTN 604
L + + + + + + H + + ++ + I G+ K+ + +
Sbjct: 3467 LVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSS------RED 3519
Query: 605 PYITLSPQDINTKWDM-VRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK 663
+ S D + W + +++ SR + LQ+ L ++ F + W+
Sbjct: 3520 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI-------FGEDEVELMNWLNEV 3572
Query: 664 VEEVGRLAAG--LAGSLEEQMAGLRQQEQNIINYKTNIDR--LEGDHQLLQ----ESLVF 715
+++ +L+ L +Q + LR +++I+ K N+D+ L G L Q E L+
Sbjct: 3573 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3632
Query: 716 DNKHTVYSMEHIRVGWE---QLLTSIARTINE 744
+K +E I+ ++ +L T +A+T+ +
Sbjct: 3633 QDK-----LEAIKARYKDITKLSTDVAKTLEQ 3659
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 236 bits (602), Expect = 7e-62
Identities = 140/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
+K Q+KTFT W N HL K + ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFH+
Sbjct: 74 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 132
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 133 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 192
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW Q+ T Y + +NF T W+DG A+IH++RPDLID + + NL
Sbjct: 193 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 252
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
AF VAEK + + ++LD ED V+ PDEK+++TYVS Y AF +
Sbjct: 253 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 303
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
+ N K + EY+ + + L++WIR V + R + ++ + ++ P
Sbjct: 304 IGANDVEVKWI-EYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 362
Query: 340 PRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSE 399
P+ EK +++ + L+ + +G +DI W L E L E
Sbjct: 363 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 419
Query: 400 IRRLQRLQHLAEKFRQKASLHE 421
+ RL+ LQ +A + ++ + + E
Sbjct: 420 VERLEMLQQIANRVQRDSVICE 441
Score = 53.5 bits (127), Expect = 9e-07
Identities = 113/570 (19%), Positives = 217/570 (38%), Gaps = 83/570 (14%)
Query: 234 KMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLA-------VNQEN 286
++L +DI++ IMT S E+ ++ ++ KVL +N E
Sbjct: 3831 EILRHKDIIDDLVKSGHKIMTACS--------EEEKQSMKKKLDKVLKNYDTICQINSER 3882
Query: 287 EKLMEEYEKLASELLEWIRRTVPWL-ENRVGEPSMSAMQRKLEDFRDYRRLHKPPR---I 342
+E + L ++ E PWL E + + A + E R + H+ R
Sbjct: 3883 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3942
Query: 343 QEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRR 402
+ K ++ T L LS P EG + + A D L S+I+
Sbjct: 3943 EHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVA-----------ADTLYSQIKE 3985
Query: 403 --LQRLQHLAEKFRQKASLHEAWTRGKE------EMLSQRDYDSALLQEVRALLRRHEAF 454
+R L E Q H+ + E E L Q SA +++++ + ++
Sbjct: 3986 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 4045
Query: 455 ESDLAAHQDRVEHIAALAQEL------NELDYHEAASVNSRCQAICDQWDNLGTLTQKRR 508
D+ Q E + +E+ + D A +V + + W+N+ TL ++R
Sbjct: 4046 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDI-SAKAVQDKLDQMVFIWENIHTLVEERE 4104
Query: 509 DALERMEKLLETI--DQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHD 566
L + +L E D + L + + DL+D + SV + Q A +
Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDT------QDFIRDLEDPGIDPSVVKQQQ--EAAE 4156
Query: 567 QFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVP 626
+ + E ++ + E+ C P + S ++N+ WD + K
Sbjct: 4157 TIREEIDGLQEELDIVINLGSELIAACGE------PDKPIVKKSIDELNSAWDSLNKAWK 4210
Query: 627 SRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQ---AKVEEVGRLAAGLAGSLEEQMA 683
R L+E + + Q+ A+ W+ K+ + + L ++++Q+
Sbjct: 4211 DRIDKLEEAM-------QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE-TVKQQIE 4262
Query: 684 GLRQQEQNIINYKTNIDRLEGDHQLLQESLVFD-NKHTVYS-MEHIRVGWEQLLTSIART 741
L+Q + + ++RL +LL + + + +KHTV + +++ W+ L I
Sbjct: 4263 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINR 4322
Query: 742 INEVENQVLTRDAKGLSQEQLNEFRASFNH 771
+++E +L A G Q L+E A H
Sbjct: 4323 QHKLEGALL---ALGQFQHALDELLAWLTH 4349
Score = 50.4 bits (119), Expect = 7e-06
Identities = 77/366 (21%), Positives = 136/366 (37%), Gaps = 52/366 (14%)
Query: 290 MEEYEKLASELLEWIRRTVPWLENRVGE-PSMSAMQRKLEDFRDYRRLHKPPRIQEKCQL 348
+EE + A + + ++ W++ G+ SMS + LE + K + E Q
Sbjct: 4216 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK-SEAYQQ 4274
Query: 349 EINFNTLQTKLRLSHRPAFMPSEGKLVSD----IANAWRGLEQVEKGYEDWLLSEIRRLQ 404
+I L + L + S+ V D + W LE+ + L + L
Sbjct: 4275 QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG 4334
Query: 405 RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
+ QH ++ AW E +LS++ + + L +H ++D+ AHQ
Sbjct: 4335 QFQHALDELL-------AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4387
Query: 465 VEHIAALAQELNELDY-HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQ 523
VE + +L E EA+++ ++ + + +W N+ T++R+
Sbjct: 4388 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQ-------------- 4433
Query: 524 LQLEFARRAAPFNNWLDGAVEDLQDVWLVHS-------------VEETQSLLTAHDQFKA 570
QL+ A R A G +EDLQ WL + E + L H + A
Sbjct: 4434 -QLDGALRQA---KGFHGEIEDLQQ-WLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4488
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
+ ++M QK Q P S I ++ KW+ V + R
Sbjct: 4489 AFEAKEETYKSLM------QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4542
Query: 631 TLQEEL 636
L+E L
Sbjct: 4543 KLEEAL 4548
Score = 48.1 bits (113), Expect = 4e-05
Identities = 63/314 (20%), Positives = 131/314 (41%), Gaps = 25/314 (7%)
Query: 344 EKCQLEINFNTLQTKLR--LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIR 401
+K + EI Q K+ L + + E L ++++ G+ + K E + ++
Sbjct: 2734 QKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQ 2793
Query: 402 RLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
LQ + +F+Q + +AW K+E ++ SA L + +L++ H+ F L A
Sbjct: 2794 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ 2853
Query: 462 QDRVEHIAALAQE-LNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDAL-ERMEKLLE 519
E A + L + E A++ + I WD ++R + L E +EK L+
Sbjct: 2854 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2913
Query: 520 TIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRER 579
+Q++ + W+D +L+++ E ++ + + K+ E D+
Sbjct: 2914 YKEQVETLWP--------WIDKCQNNLEEIKFCLDPAEGENSIA---KLKSLQKEMDQHF 2962
Query: 580 GAIMGIQGEIQKICQTYGLRPCSTN-PYITLSPQDINTKWDMVRKLVPSRDQTLQEELAR 638
G + + + L C + +T + + K DMV + + S+ L+ +
Sbjct: 2963 GMVELLNNTANSL-----LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 3017
Query: 639 ----QQVNERLRRQ 648
Q+V++ +RQ
Sbjct: 3018 FKEFQEVSKESKRQ 3031
Score = 40.0 bits (92), Expect = 0.010
Identities = 82/423 (19%), Positives = 159/423 (37%), Gaps = 52/423 (12%)
Query: 383 RGLEQVEKGYEDWLLSEIRRLQ---RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSA 439
+ +++++ YE L ++++ LQ EKF + E W + E+ L + +
Sbjct: 1849 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1908
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDN 499
+ + L+R ++F D+ +H+ + +I + E A S + R D
Sbjct: 1909 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLE----AAKSCSKRDGGKVDTSAT 1964
Query: 500 LGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD---GAVEDLQDVWLVHSVE 556
+ +K A +R L + L + ++ D G + LQ S
Sbjct: 1965 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2024
Query: 557 ETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTY--------GLRPCSTNPYIT 608
++ + + L E +G I Q ++K+ +T L P + T
Sbjct: 2025 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2084
Query: 609 LSPQDINTKWDMVRKLVPSRDQTLQEELARQ-QVNERLRRQFAAQANAIGPWIQAKVEEV 667
L DI +++ + K V R++ LQ L R V + L N +++ ++E
Sbjct: 2085 L--DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN-----VESSLKEQ 2137
Query: 668 GRLAAGLAG---------SLEEQMAGLRQQEQNIINYK-------------TNIDRLEGD 705
G++ LE+ +AG RQ N +N K +++ D
Sbjct: 2138 GQVPLNSTALQDIISKNIMLEQDIAG-RQSSINAMNEKVKKFMETTDPSTASSLQAKMKD 2196
Query: 706 HQLLQESLVFDNKHTVYSMEHIRVGWE--QLLTSIARTINEVENQVLTR-DAKGLSQEQL 762
+K T+ ME ++ E + L+ +T E + Q LT D G +L
Sbjct: 2197 LSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2256
Query: 763 NEF 765
+++
Sbjct: 2257 SQY 2259
Score = 38.1 bits (87), Expect = 0.037
Identities = 68/305 (22%), Positives = 112/305 (36%), Gaps = 35/305 (11%)
Query: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYED---WLLSEIRRLQ-RLQHLAEKFRQK 416
+ + AF GK S + R ++ +G D W+ +++ L R + + K
Sbjct: 4808 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4867
Query: 417 ASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELN 476
+ EA R EE S L E LR H D A + ++ ++L
Sbjct: 4868 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4927
Query: 477 E--LDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAA- 533
E + ++A ++ AIC D++ T+ R E++L Q Q A A
Sbjct: 4928 EKRAELNKATTMGDTVLAICHP-DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4986
Query: 534 ------------PFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
+ W + + D + +EE ++L+ H F + E R+
Sbjct: 4987 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTF---MEEMTRK--- 5040
Query: 582 IMGIQGEIQKICQTYGLR---PCSTNPYI-TLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
Q ++ K+ +TY R P S +I L K L PS QT Q E
Sbjct: 5041 ----QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQT-QIETK 5095
Query: 638 RQQVN 642
+VN
Sbjct: 5096 NPRVN 5100
Score = 34.3 bits (77), Expect = 0.54
Identities = 99/572 (17%), Positives = 216/572 (37%), Gaps = 80/572 (13%)
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
NT E+ ++ + LD+ V + + F + AN+ CK+
Sbjct: 3132 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3191
Query: 280 LAVNQENEK----LMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDF----R 331
+ +E + + E L+ + + + R + E + ++LE+F +
Sbjct: 3192 MLATEETSPDLVGIKRDLEALSKQCNKLLDRA------QAREEQVEGTIKRLEEFYSKLK 3245
Query: 332 DYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFM-----PSEGKLVSDIANAWRGLE 386
++ L + E+ Q + T +L+ F P +GK D+ +GL
Sbjct: 3246 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ-QDVNWLGQGLI 3304
Query: 387 Q----------VEKGYED----WLLSEIRRLQRLQHLAE------KFRQKASLHEAWTRG 426
Q +E +D W + QR L E +F+ +W
Sbjct: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL-NELDYHEAAS 485
EE+++ + SA + V+A ++ + + L + VE I +++ + +
Sbjct: 3365 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK 3424
Query: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVED 545
+ + + +W+ L + R + LE I + +F P N WL +
Sbjct: 3425 ILKQLSLLDSRWEALLNKAETRN-------RQLEGISVVAQQFHETLEPLNEWLTTIEKR 3477
Query: 546 LQDVWLVHS-VEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTN 604
L + + + + + + H + + ++ + I G+ K+ + +
Sbjct: 3478 LVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSS------RED 3530
Query: 605 PYITLSPQDINTKWDM-VRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK 663
+ S D + W + +++ SR + LQ+ L ++ F + W+
Sbjct: 3531 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI-------FGEDEVELMNWLNEV 3583
Query: 664 VEEVGRLAAG--LAGSLEEQMAGLRQQEQNIINYKTNIDR--LEGDHQLLQ----ESLVF 715
+++ +L+ L +Q + LR +++I+ K N+D+ L G L Q E L+
Sbjct: 3584 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3643
Query: 716 DNKHTVYSMEHIRVGWE---QLLTSIARTINE 744
+K +E I+ ++ +L T +A+T+ +
Sbjct: 3644 QDK-----LEAIKARYKDITKLSTDVAKTLEQ 3670
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 236 bits (602), Expect = 7e-62
Identities = 140/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
+K Q+KTFT W N HL K + ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFH+
Sbjct: 212 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 270
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 271 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 330
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW Q+ T Y + +NF T W+DG A+IH++RPDLID + + NL
Sbjct: 331 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 390
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
AF VAEK + + ++LD ED V+ PDEK+++TYVS Y AF +
Sbjct: 391 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 441
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
+ N K + EY+ + + L++WIR V + R + ++ + ++ P
Sbjct: 442 IGANDVEVKWI-EYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 500
Query: 340 PRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSE 399
P+ EK +++ + L+ + +G +DI W L E L E
Sbjct: 501 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 557
Query: 400 IRRLQRLQHLAEKFRQKASLHE 421
+ RL+ LQ +A + ++ + + E
Sbjct: 558 VERLEMLQQIANRVQRDSVICE 579
Score = 53.5 bits (127), Expect = 9e-07
Identities = 113/570 (19%), Positives = 217/570 (38%), Gaps = 83/570 (14%)
Query: 234 KMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLA-------VNQEN 286
++L +DI++ IMT S E+ ++ ++ KVL +N E
Sbjct: 3969 EILRHKDIIDDLVKSGHKIMTACS--------EEEKQSMKKKLDKVLKNYDTICQINSER 4020
Query: 287 EKLMEEYEKLASELLEWIRRTVPWL-ENRVGEPSMSAMQRKLEDFRDYRRLHKPPR---I 342
+E + L ++ E PWL E + + A + E R + H+ R
Sbjct: 4021 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 4080
Query: 343 QEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRR 402
+ K ++ T L LS P EG + + A D L S+I+
Sbjct: 4081 EHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVA-----------ADTLYSQIKE 4123
Query: 403 --LQRLQHLAEKFRQKASLHEAWTRGKE------EMLSQRDYDSALLQEVRALLRRHEAF 454
+R L E Q H+ + E E L Q SA +++++ + ++
Sbjct: 4124 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 4183
Query: 455 ESDLAAHQDRVEHIAALAQEL------NELDYHEAASVNSRCQAICDQWDNLGTLTQKRR 508
D+ Q E + +E+ + D A +V + + W+N+ TL ++R
Sbjct: 4184 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDI-SAKAVQDKLDQMVFIWENIHTLVEERE 4242
Query: 509 DALERMEKLLETI--DQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHD 566
L + +L E D + L + + DL+D + SV + Q A +
Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDT------QDFIRDLEDPGIDPSVVKQQQ--EAAE 4294
Query: 567 QFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVP 626
+ + E ++ + E+ C P + S ++N+ WD + K
Sbjct: 4295 TIREEIDGLQEELDIVINLGSELIAACGE------PDKPIVKKSIDELNSAWDSLNKAWK 4348
Query: 627 SRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQ---AKVEEVGRLAAGLAGSLEEQMA 683
R L+E + + Q+ A+ W+ K+ + + L ++++Q+
Sbjct: 4349 DRIDKLEEAM-------QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE-TVKQQIE 4400
Query: 684 GLRQQEQNIINYKTNIDRLEGDHQLLQESLVFD-NKHTVYS-MEHIRVGWEQLLTSIART 741
L+Q + + ++RL +LL + + + +KHTV + +++ W+ L I
Sbjct: 4401 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINR 4460
Query: 742 INEVENQVLTRDAKGLSQEQLNEFRASFNH 771
+++E +L A G Q L+E A H
Sbjct: 4461 QHKLEGALL---ALGQFQHALDELLAWLTH 4487
Score = 50.4 bits (119), Expect = 7e-06
Identities = 77/366 (21%), Positives = 136/366 (37%), Gaps = 52/366 (14%)
Query: 290 MEEYEKLASELLEWIRRTVPWLENRVGE-PSMSAMQRKLEDFRDYRRLHKPPRIQEKCQL 348
+EE + A + + ++ W++ G+ SMS + LE + K + E Q
Sbjct: 4354 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK-SEAYQQ 4412
Query: 349 EINFNTLQTKLRLSHRPAFMPSEGKLVSD----IANAWRGLEQVEKGYEDWLLSEIRRLQ 404
+I L + L + S+ V D + W LE+ + L + L
Sbjct: 4413 QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG 4472
Query: 405 RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
+ QH ++ AW E +LS++ + + L +H ++D+ AHQ
Sbjct: 4473 QFQHALDELL-------AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4525
Query: 465 VEHIAALAQELNELDY-HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQ 523
VE + +L E EA+++ ++ + + +W N+ T++R+
Sbjct: 4526 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQ-------------- 4571
Query: 524 LQLEFARRAAPFNNWLDGAVEDLQDVWLVHS-------------VEETQSLLTAHDQFKA 570
QL+ A R A G +EDLQ WL + E + L H + A
Sbjct: 4572 -QLDGALRQA---KGFHGEIEDLQQ-WLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4626
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
+ ++M QK Q P S I ++ KW+ V + R
Sbjct: 4627 AFEAKEETYKSLM------QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4680
Query: 631 TLQEEL 636
L+E L
Sbjct: 4681 KLEEAL 4686
Score = 48.1 bits (113), Expect = 4e-05
Identities = 63/314 (20%), Positives = 131/314 (41%), Gaps = 25/314 (7%)
Query: 344 EKCQLEINFNTLQTKLR--LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIR 401
+K + EI Q K+ L + + E L ++++ G+ + K E + ++
Sbjct: 2872 QKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQ 2931
Query: 402 RLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
LQ + +F+Q + +AW K+E ++ SA L + +L++ H+ F L A
Sbjct: 2932 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ 2991
Query: 462 QDRVEHIAALAQE-LNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDAL-ERMEKLLE 519
E A + L + E A++ + I WD ++R + L E +EK L+
Sbjct: 2992 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 3051
Query: 520 TIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRER 579
+Q++ + W+D +L+++ E ++ + + K+ E D+
Sbjct: 3052 YKEQVETLWP--------WIDKCQNNLEEIKFCLDPAEGENSIA---KLKSLQKEMDQHF 3100
Query: 580 GAIMGIQGEIQKICQTYGLRPCSTN-PYITLSPQDINTKWDMVRKLVPSRDQTLQEELAR 638
G + + + L C + +T + + K DMV + + S+ L+ +
Sbjct: 3101 GMVELLNNTANSL-----LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 3155
Query: 639 ----QQVNERLRRQ 648
Q+V++ +RQ
Sbjct: 3156 FKEFQEVSKESKRQ 3169
Score = 40.0 bits (92), Expect = 0.010
Identities = 82/423 (19%), Positives = 159/423 (37%), Gaps = 52/423 (12%)
Query: 383 RGLEQVEKGYEDWLLSEIRRLQ---RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSA 439
+ +++++ YE L ++++ LQ EKF + E W + E+ L + +
Sbjct: 1987 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 2046
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDN 499
+ + L+R ++F D+ +H+ + +I + E A S + R D
Sbjct: 2047 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLE----AAKSCSKRDGGKVDTSAT 2102
Query: 500 LGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD---GAVEDLQDVWLVHSVE 556
+ +K A +R L + L + ++ D G + LQ S
Sbjct: 2103 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 2162
Query: 557 ETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTY--------GLRPCSTNPYIT 608
++ + + L E +G I Q ++K+ +T L P + T
Sbjct: 2163 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2222
Query: 609 LSPQDINTKWDMVRKLVPSRDQTLQEELARQ-QVNERLRRQFAAQANAIGPWIQAKVEEV 667
L DI +++ + K V R++ LQ L R V + L N +++ ++E
Sbjct: 2223 L--DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN-----VESSLKEQ 2275
Query: 668 GRLAAGLAG---------SLEEQMAGLRQQEQNIINYK-------------TNIDRLEGD 705
G++ LE+ +AG RQ N +N K +++ D
Sbjct: 2276 GQVPLNSTALQDIISKNIMLEQDIAG-RQSSINAMNEKVKKFMETTDPSTASSLQAKMKD 2334
Query: 706 HQLLQESLVFDNKHTVYSMEHIRVGWE--QLLTSIARTINEVENQVLTR-DAKGLSQEQL 762
+K T+ ME ++ E + L+ +T E + Q LT D G +L
Sbjct: 2335 LSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2394
Query: 763 NEF 765
+++
Sbjct: 2395 SQY 2397
Score = 38.1 bits (87), Expect = 0.037
Identities = 68/305 (22%), Positives = 112/305 (36%), Gaps = 35/305 (11%)
Query: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYED---WLLSEIRRLQ-RLQHLAEKFRQK 416
+ + AF GK S + R ++ +G D W+ +++ L R + + K
Sbjct: 4946 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 5005
Query: 417 ASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELN 476
+ EA R EE S L E LR H D A + ++ ++L
Sbjct: 5006 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 5065
Query: 477 E--LDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAA- 533
E + ++A ++ AIC D++ T+ R E++L Q Q A A
Sbjct: 5066 EKRAELNKATTMGDTVLAICHP-DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 5124
Query: 534 ------------PFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
+ W + + D + +EE ++L+ H F + E R+
Sbjct: 5125 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTF---MEEMTRK--- 5178
Query: 582 IMGIQGEIQKICQTYGLR---PCSTNPYI-TLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
Q ++ K+ +TY R P S +I L K L PS QT Q E
Sbjct: 5179 ----QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQT-QIETK 5233
Query: 638 RQQVN 642
+VN
Sbjct: 5234 NPRVN 5238
Score = 34.3 bits (77), Expect = 0.54
Identities = 99/572 (17%), Positives = 216/572 (37%), Gaps = 80/572 (13%)
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
NT E+ ++ + LD+ V + + F + AN+ CK+
Sbjct: 3270 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3329
Query: 280 LAVNQENEK----LMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDF----R 331
+ +E + + E L+ + + + R + E + ++LE+F +
Sbjct: 3330 MLATEETSPDLVGIKRDLEALSKQCNKLLDRA------QAREEQVEGTIKRLEEFYSKLK 3383
Query: 332 DYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFM-----PSEGKLVSDIANAWRGLE 386
++ L + E+ Q + T +L+ F P +GK D+ +GL
Sbjct: 3384 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ-QDVNWLGQGLI 3442
Query: 387 Q----------VEKGYED----WLLSEIRRLQRLQHLAE------KFRQKASLHEAWTRG 426
Q +E +D W + QR L E +F+ +W
Sbjct: 3443 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3502
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL-NELDYHEAAS 485
EE+++ + SA + V+A ++ + + L + VE I +++ + +
Sbjct: 3503 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK 3562
Query: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVED 545
+ + + +W+ L + R + LE I + +F P N WL +
Sbjct: 3563 ILKQLSLLDSRWEALLNKAETRN-------RQLEGISVVAQQFHETLEPLNEWLTTIEKR 3615
Query: 546 LQDVWLVHS-VEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTN 604
L + + + + + + H + + ++ + I G+ K+ + +
Sbjct: 3616 LVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSS------RED 3668
Query: 605 PYITLSPQDINTKWDM-VRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK 663
+ S D + W + +++ SR + LQ+ L ++ F + W+
Sbjct: 3669 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI-------FGEDEVELMNWLNEV 3721
Query: 664 VEEVGRLAAG--LAGSLEEQMAGLRQQEQNIINYKTNIDR--LEGDHQLLQ----ESLVF 715
+++ +L+ L +Q + LR +++I+ K N+D+ L G L Q E L+
Sbjct: 3722 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3781
Query: 716 DNKHTVYSMEHIRVGWE---QLLTSIARTINE 744
+K +E I+ ++ +L T +A+T+ +
Sbjct: 3782 QDK-----LEAIKARYKDITKLSTDVAKTLEQ 3808
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 236 bits (602), Expect = 7e-62
Identities = 140/382 (36%), Positives = 211/382 (55%), Gaps = 18/382 (4%)
Query: 44 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHK 103
+K Q+KTFT W N HL K + ++ ED R+G L+ LLEV+SG+ LPR +KG+MRFH+
Sbjct: 34 DKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR-EKGRMRFHR 92
Query: 104 IANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDISV----EETS 159
+ NV ALD++ + VKLV+I ++I DGN K+TLG+IWTIIL F I DI V E+ S
Sbjct: 93 LQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESEDMS 152
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
AKE LLLW Q+ T Y + +NF T W+DG A+IH++RPDLID + + NL
Sbjct: 153 AKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLANL 212
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
AF VAEK + + ++LD ED V+ PDEK+++TYVS Y AF +
Sbjct: 213 EHAFYVAEK-IGVIRLLDPED-VDVSSPDEKSVITYVSSLYDAFPKVPEGGEG------- 263
Query: 280 LAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKP 339
+ N K + EY+ + + L++WIR V + R + ++ + ++ P
Sbjct: 264 IGANDVEVKWI-EYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIP 322
Query: 340 PRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSE 399
P+ EK +++ + L+ + +G +DI W L E L E
Sbjct: 323 PKETEKSKIKRLYKLLEIWIEFGRIKLL---QGYHPNDIEKEWGKLIIAMLEREKALRPE 379
Query: 400 IRRLQRLQHLAEKFRQKASLHE 421
+ RL+ LQ +A + ++ + + E
Sbjct: 380 VERLEMLQQIANRVQRDSVICE 401
Score = 53.5 bits (127), Expect = 9e-07
Identities = 113/570 (19%), Positives = 217/570 (38%), Gaps = 83/570 (14%)
Query: 234 KMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKVLA-------VNQEN 286
++L +DI++ IMT S E+ ++ ++ KVL +N E
Sbjct: 3791 EILRHKDIIDDLVKSGHKIMTACS--------EEEKQSMKKKLDKVLKNYDTICQINSER 3842
Query: 287 EKLMEEYEKLASELLEWIRRTVPWL-ENRVGEPSMSAMQRKLEDFRDYRRLHKPPR---I 342
+E + L ++ E PWL E + + A + E R + H+ R
Sbjct: 3843 YLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIA 3902
Query: 343 QEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIRR 402
+ K ++ T L LS P EG + + A D L S+I+
Sbjct: 3903 EHKPHIDKMNKTGPQLLELS------PGEGFSIQEKYVA-----------ADTLYSQIKE 3945
Query: 403 --LQRLQHLAEKFRQKASLHEAWTRGKE------EMLSQRDYDSALLQEVRALLRRHEAF 454
+R L E Q H+ + E E L Q SA +++++ + ++
Sbjct: 3946 DVKKRAVALDEAISQSTQFHDKIDQILESLERIVERLRQPPSISAEVEKIKEQISENKNV 4005
Query: 455 ESDLAAHQDRVEHIAALAQEL------NELDYHEAASVNSRCQAICDQWDNLGTLTQKRR 508
D+ Q E + +E+ + D A +V + + W+N+ TL ++R
Sbjct: 4006 SVDMEKLQPLYETLKQRGEEMIARSGGTDKDI-SAKAVQDKLDQMVFIWENIHTLVEERE 4064
Query: 509 DALERMEKLLETI--DQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHD 566
L + +L E D + L + + DL+D + SV + Q A +
Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDT------QDFIRDLEDPGIDPSVVKQQQ--EAAE 4116
Query: 567 QFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVP 626
+ + E ++ + E+ C P + S ++N+ WD + K
Sbjct: 4117 TIREEIDGLQEELDIVINLGSELIAACGE------PDKPIVKKSIDELNSAWDSLNKAWK 4170
Query: 627 SRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQ---AKVEEVGRLAAGLAGSLEEQMA 683
R L+E + + Q+ A+ W+ K+ + + L ++++Q+
Sbjct: 4171 DRIDKLEEAM-------QAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLE-TVKQQIE 4222
Query: 684 GLRQQEQNIINYKTNIDRLEGDHQLLQESLVFD-NKHTVYS-MEHIRVGWEQLLTSIART 741
L+Q + + ++RL +LL + + + +KHTV + +++ W+ L I
Sbjct: 4223 ELKQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINR 4282
Query: 742 INEVENQVLTRDAKGLSQEQLNEFRASFNH 771
+++E +L A G Q L+E A H
Sbjct: 4283 QHKLEGALL---ALGQFQHALDELLAWLTH 4309
Score = 50.4 bits (119), Expect = 7e-06
Identities = 77/366 (21%), Positives = 136/366 (37%), Gaps = 52/366 (14%)
Query: 290 MEEYEKLASELLEWIRRTVPWLENRVGE-PSMSAMQRKLEDFRDYRRLHKPPRIQEKCQL 348
+EE + A + + ++ W++ G+ SMS + LE + K + E Q
Sbjct: 4176 LEEAMQAAVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFK-SEAYQQ 4234
Query: 349 EINFNTLQTKLRLSHRPAFMPSEGKLVSD----IANAWRGLEQVEKGYEDWLLSEIRRLQ 404
+I L + L + S+ V D + W LE+ + L + L
Sbjct: 4235 QIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALG 4294
Query: 405 RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDR 464
+ QH ++ AW E +LS++ + + L +H ++D+ AHQ
Sbjct: 4295 QFQHALDELL-------AWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQST 4347
Query: 465 VEHIAALAQELNELDY-HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQ 523
VE + +L E EA+++ ++ + + +W N+ T++R+
Sbjct: 4348 VEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQ-------------- 4393
Query: 524 LQLEFARRAAPFNNWLDGAVEDLQDVWLVHS-------------VEETQSLLTAHDQFKA 570
QL+ A R A G +EDLQ WL + E + L H + A
Sbjct: 4394 -QLDGALRQA---KGFHGEIEDLQQ-WLTDTERHLLASKPLGGLPETAKEQLNVHMEVCA 4448
Query: 571 TLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQ 630
+ ++M QK Q P S I ++ KW+ V + R
Sbjct: 4449 AFEAKEETYKSLM------QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKT 4502
Query: 631 TLQEEL 636
L+E L
Sbjct: 4503 KLEEAL 4508
Score = 48.1 bits (113), Expect = 4e-05
Identities = 63/314 (20%), Positives = 131/314 (41%), Gaps = 25/314 (7%)
Query: 344 EKCQLEINFNTLQTKLR--LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYEDWLLSEIR 401
+K + EI Q K+ L + + E L ++++ G+ + K E + ++
Sbjct: 2694 QKMKQEIQQEKKQIKVAQALCEDLSALVKEEYLKAELSRQLEGILKSFKDVEQKAENHVQ 2753
Query: 402 RLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAH 461
LQ + +F+Q + +AW K+E ++ SA L + +L++ H+ F L A
Sbjct: 2754 HLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKDFSKTLTAQ 2813
Query: 462 QDRVEHIAALAQE-LNELDYHEAASVNSRCQAICDQWDNLGTLTQKRRDAL-ERMEKLLE 519
E A + L + E A++ + I WD ++R + L E +EK L+
Sbjct: 2814 SHMYEKTIAEGENLLLKTQGSEKAALQLQLNTIKTNWDTFNKQVKERENKLKESLEKALK 2873
Query: 520 TIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRER 579
+Q++ + W+D +L+++ E ++ + + K+ E D+
Sbjct: 2874 YKEQVETLWP--------WIDKCQNNLEEIKFCLDPAEGENSIA---KLKSLQKEMDQHF 2922
Query: 580 GAIMGIQGEIQKICQTYGLRPCSTN-PYITLSPQDINTKWDMVRKLVPSRDQTLQEELAR 638
G + + + L C + +T + + K DMV + + S+ L+ +
Sbjct: 2923 GMVELLNNTANSL-----LSVCEIDKEVVTDENKSLIQKVDMVTEQLHSKKFCLENMTQK 2977
Query: 639 ----QQVNERLRRQ 648
Q+V++ +RQ
Sbjct: 2978 FKEFQEVSKESKRQ 2991
Score = 40.0 bits (92), Expect = 0.010
Identities = 82/423 (19%), Positives = 159/423 (37%), Gaps = 52/423 (12%)
Query: 383 RGLEQVEKGYEDWLLSEIRRLQ---RLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSA 439
+ +++++ YE L ++++ LQ EKF + E W + E+ L + +
Sbjct: 1809 KNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEFEHWLQQSEQELENLEAGAD 1868
Query: 440 LLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDN 499
+ + L+R ++F D+ +H+ + +I + E A S + R D
Sbjct: 1869 DINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLE----AAKSCSKRDGGKVDTSAT 1924
Query: 500 LGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLD---GAVEDLQDVWLVHSVE 556
+ +K A +R L + L + ++ D G + LQ S
Sbjct: 1925 HREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCGLLAGLQACEATASKH 1984
Query: 557 ETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTY--------GLRPCSTNPYIT 608
++ + + L E +G I Q ++K+ +T L P + T
Sbjct: 1985 LSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLDARGSLLPAKNDIQKT 2044
Query: 609 LSPQDINTKWDMVRKLVPSRDQTLQEELARQ-QVNERLRRQFAAQANAIGPWIQAKVEEV 667
L DI +++ + K V R++ LQ L R V + L N +++ ++E
Sbjct: 2045 L--DDIVGRYEDLSKSVNERNEKLQITLTRSLSVQDGLDEMLDWMGN-----VESSLKEQ 2097
Query: 668 GRLAAGLAG---------SLEEQMAGLRQQEQNIINYK-------------TNIDRLEGD 705
G++ LE+ +AG RQ N +N K +++ D
Sbjct: 2098 GQVPLNSTALQDIISKNIMLEQDIAG-RQSSINAMNEKVKKFMETTDPSTASSLQAKMKD 2156
Query: 706 HQLLQESLVFDNKHTVYSMEHIRVGWE--QLLTSIARTINEVENQVLTR-DAKGLSQEQL 762
+K T+ ME ++ E + L+ +T E + Q LT D G +L
Sbjct: 2157 LSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTEVDVPGKDVTEL 2216
Query: 763 NEF 765
+++
Sbjct: 2217 SQY 2219
Score = 38.1 bits (87), Expect = 0.037
Identities = 68/305 (22%), Positives = 112/305 (36%), Gaps = 35/305 (11%)
Query: 361 LSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYED---WLLSEIRRLQ-RLQHLAEKFRQK 416
+ + AF GK S + R ++ +G D W+ +++ L R + + K
Sbjct: 4768 IDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISK 4827
Query: 417 ASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELN 476
+ EA R EE S L E LR H D A + ++ ++L
Sbjct: 4828 QTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLE 4887
Query: 477 E--LDYHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAA- 533
E + ++A ++ AIC D++ T+ R E++L Q Q A A
Sbjct: 4888 EKRAELNKATTMGDTVLAICHP-DSITTIKHWITIIRARFEEVLAWAKQHQQRLASALAG 4946
Query: 534 ------------PFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA 581
+ W + + D + +EE ++L+ H F + E R+
Sbjct: 4947 LIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTF---MEEMTRK--- 5000
Query: 582 IMGIQGEIQKICQTYGLR---PCSTNPYI-TLSPQDINTKWDMVRKLVPSRDQTLQEELA 637
Q ++ K+ +TY R P S +I L K L PS QT Q E
Sbjct: 5001 ----QPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQT-QIETK 5055
Query: 638 RQQVN 642
+VN
Sbjct: 5056 NPRVN 5060
Score = 34.3 bits (77), Expect = 0.54
Identities = 99/572 (17%), Positives = 216/572 (37%), Gaps = 80/572 (13%)
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYHAFAGAEQAETAANRICKV 279
NT E+ ++ + LD+ V + + F + AN+ CK+
Sbjct: 3092 NTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKETIKAFLKKLEALMASNDNANKTCKM 3151
Query: 280 LAVNQENEK----LMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDF----R 331
+ +E + + E L+ + + + R + E + ++LE+F +
Sbjct: 3152 MLATEETSPDLVGIKRDLEALSKQCNKLLDRA------QAREEQVEGTIKRLEEFYSKLK 3205
Query: 332 DYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFM-----PSEGKLVSDIANAWRGLE 386
++ L + E+ Q + T +L+ F P +GK D+ +GL
Sbjct: 3206 EFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQ-QDVNWLGQGLI 3264
Query: 387 Q----------VEKGYED----WLLSEIRRLQRLQHLAE------KFRQKASLHEAWTRG 426
Q +E +D W + QR L E +F+ +W
Sbjct: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324
Query: 427 KEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL-NELDYHEAAS 485
EE+++ + SA + V+A ++ + + L + VE I +++ + +
Sbjct: 3325 TEELVANQKPPSAEFKVVKAQIQEQKLLQRLLDDRKSTVEVIKREGEKIATTAEPADKVK 3384
Query: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVED 545
+ + + +W+ L + R + LE I + +F P N WL +
Sbjct: 3385 ILKQLSLLDSRWEALLNKAETRN-------RQLEGISVVAQQFHETLEPLNEWLTTIEKR 3437
Query: 546 LQDVWLVHS-VEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTN 604
L + + + + + + H + + ++ + I G+ K+ + +
Sbjct: 3438 LVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQAVSI-GQSLKVLSS------RED 3490
Query: 605 PYITLSPQDINTKWDM-VRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAK 663
+ S D + W + +++ SR + LQ+ L ++ F + W+
Sbjct: 3491 KDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKI-------FGEDEVELMNWLNEV 3543
Query: 664 VEEVGRLAAG--LAGSLEEQMAGLRQQEQNIINYKTNIDR--LEGDHQLLQ----ESLVF 715
+++ +L+ L +Q + LR +++I+ K N+D+ L G L Q E L+
Sbjct: 3544 HDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLII 3603
Query: 716 DNKHTVYSMEHIRVGWE---QLLTSIARTINE 744
+K +E I+ ++ +L T +A+T+ +
Sbjct: 3604 QDK-----LEAIKARYKDITKLSTDVAKTLEQ 3630
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 231 bits (589), Expect = 2e-60
Identities = 145/406 (35%), Positives = 220/406 (54%), Gaps = 32/406 (7%)
Query: 28 EQEEDWDRDLLLDPAW----------EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGL 77
EQ++ +D +LDPA ++ Q+KTFT W N HL K I ++ ED R+G
Sbjct: 51 EQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGH 110
Query: 78 KLMLLLEVISGERLPRPDKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMT 137
L+ LLEV+SG +LPR +KG+MRFH++ NV ALDF+ + VKLV+I ++I DGN K+T
Sbjct: 111 NLISLLEVLSGIKLPR-EKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLT 169
Query: 138 LGMIWTIILRFAIQDISVE----ETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLAL 193
LG+IWTIIL F I DI + + SAKE LLLW Q+ TA Y + NF + W DG
Sbjct: 170 LGLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMF 229
Query: 194 CALIHRHRPDLIDYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIM 253
ALIHR+RPDL+D +++ NL AFEVAE+ L + ++LDAED V+ P PDEK+++
Sbjct: 230 NALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAED-VDVPSPDEKSVI 287
Query: 254 TYVSCFYHAFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLEN 313
TYVS Y AF + + E + +EY+ L+ WI++ + +
Sbjct: 288 TYVSSIYDAFPKVPEGGEGISA--------TEVDSRWQEYQSRVDSLIPWIKQHTILMSD 339
Query: 314 RVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGK 373
+ + ++ + ++ + +EK ++E + L+ + +G
Sbjct: 340 KTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGR---IKLPQGY 396
Query: 374 LVSDIANAWRGL--EQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKA 417
+D+ W L E +E+ E L + RL+ L +A K + A
Sbjct: 397 HPNDVEEEWGKLIIEMLER--EKSLRPAVERLELLLQIANKIQNGA 440
Score = 47.8 bits (112), Expect = 5e-05
Identities = 72/342 (21%), Positives = 143/342 (41%), Gaps = 38/342 (11%)
Query: 434 RDYDS--ALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDY-HEAASVNSRC 490
RD DS + +++VR L + + D+ A + H+ L+ L E ++N +C
Sbjct: 3088 RDTDSLQSQIEDVRLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQC 3147
Query: 491 QAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVW 550
G LT++ + E++E L ++ +F R+ N+ A E W
Sbjct: 3148 ----------GKLTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQW 3193
Query: 551 LVHS-VEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITL 609
+V + VE L F+ + D + + + G Q + Q+ G + C +
Sbjct: 3194 VVGTEVEIINQQLADFKMFQKE--QVDPLQMKLQQVNGLGQGLIQSAG-KDCDVQG-LEH 3249
Query: 610 SPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGR 669
++IN +W+ + K V R LQE L +F + W+ A EE+
Sbjct: 3250 DMEEINARWNTLNKKVAQRIAQLQEALLH-------CGKFQDALEPLLSWL-ADTEEL-- 3299
Query: 670 LAAGLAGSLEEQMAGLRQQEQNII-----NYKTNIDRLEGD-HQLLQESLVFDNKHTVYS 723
+A S E ++ + QEQ ++ + K +D L+ + ++ Q + + D +
Sbjct: 3300 IANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKATVDMLQAEGGRIAQSAELADREKITGQ 3359
Query: 724 MEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEF 765
+E + W +LL+ A ++E+ ++ + E +++F
Sbjct: 3360 LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDF 3401
Score = 46.6 bits (109), Expect = 1e-04
Identities = 53/248 (21%), Positives = 107/248 (43%), Gaps = 20/248 (8%)
Query: 284 QENEKLMEEYEKLASELLEWIRRTVPWLENRVGEP-SMSAMQRKLEDFRDYRRLHKPPRI 342
+E + +E+ + A + + ++ WL+N V + +M + L +D K ++
Sbjct: 4144 KERLEKLEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKV 4203
Query: 343 QEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLV----SDIANAWRGLEQVEKGYEDWLLS 398
E Q +I L + L + A ++ ++ +++ + W L + + L
Sbjct: 4204 -EVYQQQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWENLGEKIAHRQHKLEG 4262
Query: 399 EIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDL 458
+ L + QH E+ +W EE+L + S + + L +H ++D+
Sbjct: 4263 ALLALGQFQHALEELM-------SWLTHTEELLDAQRPISGDPKVIEVELAKHHVLKNDV 4315
Query: 459 AAHQDRVEHIAALAQELNELDY-HEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKL 517
AHQ VE + EL E +A+S+ SR +A+ W+++ T+ ER ++L
Sbjct: 4316 LAHQATVETVNKAGNELLESSAGDDASSLRSRLEAMNQCWESVLQKTE------EREQQL 4369
Query: 518 LETIDQLQ 525
T+ Q Q
Sbjct: 4370 QSTLQQAQ 4377
Score = 45.4 bits (106), Expect = 2e-04
Identities = 100/513 (19%), Positives = 193/513 (37%), Gaps = 87/513 (16%)
Query: 224 EVAEKYLDIPKML----DAEDIVNTPKPDEKAIM-TYVSCFYH----AFAGAEQAETAAN 274
E+AE + + K+ D +I P PD + + T S H +++ AE++
Sbjct: 1983 ELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQK 2042
Query: 275 RICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYR 334
I + +V + E L++ ++ L + V L + V + +++ + +D
Sbjct: 2043 AIAQSQSVQESLESLLQSIGEVEQNLEG---KQVSSLSSGVIQEALATNMKLKQDIA--- 2096
Query: 335 RLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQVEKGYED 394
++K LE + + + +GKL ++++ + L ++ E
Sbjct: 2097 --------RQKSSLEATREMVTRFMETADSTTAAVLQGKL-AEVSQRFEQLCLQQQEKES 2147
Query: 395 WLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLS---QRDYD-SALLQEVRALLRR 450
L + + + +HL+ K +Q + K ML+ Q D D + Q+++ L
Sbjct: 2148 SLKKLLPQAEMFEHLSGKLQQ-------FMENKSRMLASGNQPDQDITHFFQQIQELNLE 2200
Query: 451 HE-------------------AFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQ 491
E F DL HQDRV+++ EL + E S CQ
Sbjct: 2201 MEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQK-TVKEREKDASSCQ 2259
Query: 492 AICDQWDNLGTLTQKRRDALERMEKLLET---IDQLQLEFARRAAPFNNWLDGAVEDLQD 548
D++ L QK E ET +L+ + + ++W
Sbjct: 2260 EQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGT----- 2314
Query: 549 VWLVHSVEETQSLLTAHDQ--FKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPY 606
VEE T+ + + T P++ + G+I+ G + G C
Sbjct: 2315 -----LVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVG--SSVGSVNGYHTCKDLTE 2367
Query: 607 ITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEE 666
I D+N K++ + ++ R ++LQ L R + + +AN++ W+++K E
Sbjct: 2368 IQCDMSDVNLKYEKLGGVLHERQESLQAILNRME-------EVHKEANSVLQWLESKEEV 2420
Query: 667 VGRLAA--------GLAGSLEEQMAGLRQQEQN 691
+ + A + E A L + EQN
Sbjct: 2421 LKSMDAMSSPTKTETVKAQAESNKAFLAELEQN 2453
Score = 42.4 bits (98), Expect = 0.002
Identities = 84/465 (18%), Positives = 183/465 (39%), Gaps = 47/465 (10%)
Query: 262 AFAGAEQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMS 321
A A Q ET ++ K LA N++ + ++ + +P +E G S
Sbjct: 1660 AVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGA---S 1716
Query: 322 AMQRKLEDFRDYRRLHKPP-RIQEKCQL------EINFNTLQTKLRLSHRPAFMPSEGKL 374
+ L+ Y +++ P ++ ++C++ E+ L AF+ G
Sbjct: 1717 LEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHN 1776
Query: 375 VSDIANAW--RGLEQVEKGYEDWLL---SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEE 429
++ + L ++++ Y L +E++++Q LQ +KF Q E+W E+
Sbjct: 1777 LTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEK 1836
Query: 430 MLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSR 489
L + + + +LL+R +F D+ +H+ + + Q++ +++ NS
Sbjct: 1837 ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDME-------NSF 1889
Query: 490 CQAICDQWDNLGTLTQ-KRRDALERMEKLLETIDQL----------QLEFARRAAPFNNW 538
+ + +G L + K +DA ER L +L +F A W
Sbjct: 1890 KEG--KEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAW 1947
Query: 539 L---DGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQT 595
+ + VE L + Q L Q + L E + + +Q + I +
Sbjct: 1948 MQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE---HQVPVEKLQKVARDIMEI 2004
Query: 596 YGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANA 655
G P + ++ + I + + + + R LQ+ +A+ Q +
Sbjct: 2005 EG-EPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGE 2063
Query: 656 IGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNID 700
+ ++ K +V L++G+ ++E +A + +Q+I K++++
Sbjct: 2064 VEQNLEGK--QVSSLSSGV---IQEALATNMKLKQDIARQKSSLE 2103
Score = 42.4 bits (98), Expect = 0.002
Identities = 89/494 (18%), Positives = 191/494 (38%), Gaps = 58/494 (11%)
Query: 287 EKLMEEYEKLASELLEWIRRT---VPWLENRVG----EPSMSAMQRKLEDFRDYRRLHKP 339
++ ++E+ KL +W++ T +P E + E + ++ L+D+ L +
Sbjct: 2259 QEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEE 2318
Query: 340 PRIQ----EKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVS---------DIANAWRGLE 386
+ E +EI Q K + +PS G V D+ +
Sbjct: 2319 INCKGTSLENLIMEITAPDSQGKTG-----SILPSVGSSVGSVNGYHTCKDLTEIQCDMS 2373
Query: 387 QVEKGYEDW---LLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSA--LL 441
V YE L LQ + + E+ ++A+ W KEE+L D S+
Sbjct: 2374 DVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKT 2433
Query: 442 QEVRALLRRHEAFESDLAAHQDRVEHIA-ALAQELNEL-DYHEAASVNSRCQAICDQWDN 499
+ V+A ++AF ++L + +++ + ALA L + EA + + + +W+
Sbjct: 2434 ETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWER 2493
Query: 500 LGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQ 559
+T R+ LE L F + WL +E + ++ +
Sbjct: 2494 ATEVTVARQRQLEESASHLAC-------FQAAESQLRPWL---MEKELMMGVLGPLSIDP 2543
Query: 560 SLLTAH-DQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKW 618
++L A Q + L E + R + Q I G ST+ + Q IN KW
Sbjct: 2544 NMLNAQKQQVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ-VQKELQSINQKW 2602
Query: 619 DMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSL 678
+ + SR + + + + + L + + + A+G + + ++
Sbjct: 2603 VELTDKLNSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQ------------SAI 2650
Query: 679 EEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQLLTSI 738
Q ++QQ + ++++++L DH++ + + D + ++++ ++ L ++
Sbjct: 2651 STQPEAVKQQLEETSEIRSDLEQL--DHEVKEAQTLCDELSVLIGEQYLKDELKKRLETV 2708
Query: 739 ARTINEVENQVLTR 752
A + +E+ R
Sbjct: 2709 ALPLQGLEDLAADR 2722
Score = 40.8 bits (94), Expect = 0.006
Identities = 31/141 (21%), Positives = 61/141 (43%), Gaps = 6/141 (4%)
Query: 390 KGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLR 449
+G ED I RLQ ++F+Q W K+ ++ SA L+ +++ L+
Sbjct: 2713 QGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQ 2772
Query: 450 RHEAFESDLAAHQDRVEHIAALAQE--LNELDYHEAASVNSRCQAICDQWDNLGTLTQKR 507
+E F+ L H E I A + L+ E ++ ++ + + W+ L T R
Sbjct: 2773 ENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELSKKTADR 2832
Query: 508 ----RDALERMEKLLETIDQL 524
+D +++ +K ++ L
Sbjct: 2833 QSRLKDCMQKAQKYQWHVEDL 2853
Score = 38.9 bits (89), Expect = 0.022
Identities = 73/392 (18%), Positives = 153/392 (39%), Gaps = 42/392 (10%)
Query: 500 LGTLTQKRRDALERMEKLLETIDQLQLE---FARRAAPFNNWLDGAVEDLQDVWLVHSVE 556
LG L ++ +L + E L+ + LQ E F + F +WL+ + ++L+++ S
Sbjct: 1789 LGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSP 1848
Query: 557 ET-QSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTY-----GLRPCSTNPYITLS 610
ET SLL F + +G + + QK+ G P +
Sbjct: 1849 ETLPSLLKRQGSFSE---DVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDK 1905
Query: 611 PQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVEEVGRL 670
+D ++ + L L + QF A+++ W+QA V +L
Sbjct: 1906 LKDATERYTALHSKCTRLGSHLNMLLGQYH-------QFQNSADSLQAWMQACEANVEKL 1958
Query: 671 ----AAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLE---GDHQLLQESLVFDNKHTVYS 723
A G L+EQ+A +Q ++ + ++ +++L+ D ++ D++H +
Sbjct: 1959 LSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET 2018
Query: 724 MEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNHFDRKRNGMMEPD 783
+ I ++ L S+A + ++ + + QE L S ++ G
Sbjct: 2019 TDSILSHFQSLSYSLAERSSLLQKAIAQSQS---VQESLESLLQSIGEVEQNLEGKQ--- 2072
Query: 784 DFRACLISMGYDLGEVEFARIMTMVDPNAAGVVTFQAFIDFMTRETAETDTTEQVVASFK 843
+ S+ + + A M + A + +A + +TR D+T V K
Sbjct: 2073 -----VSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGK 2127
Query: 844 ILAGDKNYITPEELRRELPAKQAEYCIRRMVP 875
+ + + E+L L ++ E +++++P
Sbjct: 2128 LAEVSQRF---EQLC--LQQQEKESSLKKLLP 2154
Score = 38.5 bits (88), Expect = 0.028
Identities = 81/465 (17%), Positives = 173/465 (37%), Gaps = 73/465 (15%)
Query: 278 KVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLH 337
K L ++ +L +++ EL W+R L G+ S ++ F+ ++
Sbjct: 3594 KALRTLEQARQLATKFQSTYEELTGWLREVEEELATSGGQ---SPTGEQIPQFQQRQKEL 3650
Query: 338 KPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEG--KLVSDIANAWRGLEQVEKGYEDW 395
K ++ + L+ + L L + EG KLVSD ++ + D
Sbjct: 3651 KKEVMEHRLVLDTVNEVSRALLELV---PWRAREGLDKLVSDANEQYKLVSDTIGQRVDE 3707
Query: 396 LLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQEVRALLRRHEAFE 455
+ + I+R Q+ + Q A AW + L + A L+ +AF
Sbjct: 3708 IDAAIQRSQQ-------YEQAADAELAWVAETKRKLMALGPIRLEQDQTTAQLQVQKAFS 3760
Query: 456 SDLAAHQDRVEHIAALAQELNELDYHEAASV-NSRCQAICDQWDNLGTLTQKRRDALERM 514
D+ H+D ++ + + E+ E +V + +++ Q++ + L +R LER
Sbjct: 3761 IDIIRHKDSMDELFSHRSEIFGTCGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERA 3820
Query: 515 EKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPE 574
+ L+ +F + W +EET++L+ A LP
Sbjct: 3821 QVLVN-------QFWETYEELSPW----------------IEETRALI-------AQLPS 3850
Query: 575 ADRERGAIMGIQGEIQKICQTYGLRPCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQE 634
+ + Q E++++ ++ + + + PQ +++L P + ++E
Sbjct: 3851 PAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQ--------LKELNPEEGEMVEE 3902
Query: 635 ELAR-----QQVNERLRRQFAAQANAIGPWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQE 689
+ + Q+ E +R++ A A+ ++ E + +LE + LR
Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQ--STQITEFHDKIEPMLETLENLSSRLRMPP 3960
Query: 690 QNIINYKTNIDRLEGDHQLLQESLVFDNKHTVYSMEHIRVGWEQL 734
+D++ + DNK +E ++ +E L
Sbjct: 3961 L----IPAEVDKI--------RECISDNKSATVELEKLQPSFEAL 3993
Score = 33.5 bits (75), Expect = 0.91
Identities = 94/536 (17%), Positives = 204/536 (38%), Gaps = 77/536 (14%)
Query: 267 EQAETAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLEN-----------RV 315
E+ E+ + + +N E +E + L ++ E PW+E +
Sbjct: 3794 EKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPWIEETRALIAQLPSPAI 3853
Query: 316 GEPSMSAMQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLV 375
+ Q ++ R+ HK P I + ++ L P EG++V
Sbjct: 3854 DHEQLRQQQEEMRQLRESIAEHK-PHIDKLLKIGPQLKELN------------PEEGEMV 3900
Query: 376 SDIANAWRGLEQVEKGYEDWLLSEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRD 435
+ ++ E Y + E+R QR L E Q + E + + + + +
Sbjct: 3901 EE------KYQKAENMYAQ-IKEEVR--QRALALDEAVSQSTQITEFHDKIEPMLETLEN 3951
Query: 436 YDSAL---------LQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASV 486
S L + ++R + +++ +L Q E + +EL + + A
Sbjct: 3952 LSSRLRMPPLIPAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEEL--IGRSQGADK 4009
Query: 487 NSRCQAICDQWDNLGTLTQK-RRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVED 545
+ + I D+ D + + + A ER K L+ ++ + + AA L ++D
Sbjct: 4010 DLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAA-----LLTTIKD 4064
Query: 546 LQDVWLVHSVEE---TQSLLTAHDQFKATLPEADRERGAIMGIQGEIQ--KICQTYGLRP 600
QD+ VH +E S++ + T+ E G+ E++ +I +
Sbjct: 4065 TQDI--VHDLESPGIDPSIIKQQVEAAETIKEETD------GLHEELEFIRILGADLIFA 4116
Query: 601 C--STNPYITLSPQDINTKWDMVRKLVPSRDQTLQEEL-ARQQVNERLRRQFAAQANAIG 657
C + P + S ++N W+ + K R + L++ + A Q + L+ F N +
Sbjct: 4117 CGETEKPEVRKSIDEMNNAWENLNKTWKERLEKLEDAMQAAVQYQDTLQAMFDWLDNTV- 4175
Query: 658 PWIQAKVEEVGRLAAGLAGSLEEQMAGLRQQEQNIINYKTNIDRLEGDHQLLQESLVFDN 717
K+ + + L ++++Q+ +++ + + + +++L +L+ + +
Sbjct: 4176 ----IKLCTMPPVGTDL-NTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLKKATDET 4230
Query: 718 KHTVY--SMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNEFRASFNH 771
+ + ++ WE L IA +++E +L A G Q L E + H
Sbjct: 4231 DRDIIREPLTELKHLWENLGEKIAHRQHKLEGALL---ALGQFQHALEELMSWLTH 4283
Score = 33.1 bits (74), Expect = 1.2
Identities = 35/170 (20%), Positives = 66/170 (38%), Gaps = 9/170 (5%)
Query: 385 LEQVEKGYEDWLLSEIRRLQRLQH---LAEKFRQKASLHEAWTRGKEEMLSQRDYDSALL 441
LE +E + + L R ++L+ LA++F + A + E+ L+ +
Sbjct: 3360 LESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVGTQT 3419
Query: 442 QEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWDNLG 501
+++ + RH+A E D+ H V + Q L+ L V + ++ D+L
Sbjct: 3420 AKIQQQIIRHKALEEDIENHATDVHQAVKIGQSLSSLTSPAEQGV------LSEKIDSLQ 3473
Query: 502 TLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWL 551
+ +D R LL+ F NWL + L V++
Sbjct: 3474 ARYSEIQDRCCRKAALLDQALSNARLFGEDEVEVLNWLAEVEDKLSSVFV 3523
>gi|110611228 utrophin [Homo sapiens]
Length = 3433
Score = 196 bits (498), Expect = 8e-50
Identities = 170/634 (26%), Positives = 294/634 (46%), Gaps = 76/634 (11%)
Query: 47 QRKTFTAWCNSHLRKAGTQ-IENIEEDFRNGLKLMLLLEVISGERLPRPDKGKMRFHKIA 105
Q+KTFT W N+ K+G I ++ D ++G KL+ LLE ++G LP+ ++G R H +
Sbjct: 33 QKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPK-ERGSTRVHALN 91
Query: 106 NVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQDI------SVEETS 159
NVN+ L + V+LV+IG +IVDGN K+TLG++W+IIL + ++D+ +++T+
Sbjct: 92 NVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTN 151
Query: 160 AKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNL 219
+++ LL W ++ T PY VNV NF TSW DGLA A++HRH+PDL + K+ K PI L
Sbjct: 152 SEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERL 211
Query: 220 NTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCFYH---------AFAGAEQAE 270
AF A+ YL I K+LD ED+ PD+K+I+ Y++ + A E
Sbjct: 212 EHAFSKAQTYLGIEKLLDPEDVA-VQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLP 270
Query: 271 TAANRICKVLAVNQENEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDF 330
+ C+ A+N ++ EE+E +E + + + + Q LE+
Sbjct: 271 RKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEV---------DMDLDSYQIALEEV 321
Query: 331 RDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAWRGLEQV-- 388
+ L QE Q +I+ + + K + + AFM S + + + Q+
Sbjct: 322 LTW-LLSAEDTFQE--QDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLIT 378
Query: 389 ------EKGYE----------DWLLSEIRRLQRLQHLAEKFR--QKASLHE--AWTRGKE 428
E+ +E W + + R L + QK L + AW E
Sbjct: 379 QGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTE 438
Query: 429 EMLSQR-----DYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEA 483
E + + D D LQ+ LL H++ +SDL A Q +V + + ++E A
Sbjct: 439 ERIQKMETCPLDDDVKSLQK---LLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESA 495
Query: 484 ASV-NSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGA 542
++ + Q + ++W + T++R + L+ I+ L E WL
Sbjct: 496 TAILEDQLQKLGERWTAVCRWTEERWNRLQE-------INILWQELLEEQCLLKAWLTEK 548
Query: 543 VEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYG--LRP 600
E L V + ++ + L + + + + +R + ++ +I Q G L
Sbjct: 549 EEALNKV-QTSNFKDQKELSVSVRRLAILKEDMEMKRQTL----DQLSEIGQDVGQLLDN 603
Query: 601 CSTNPYITLSPQDINTKWD-MVRKLVPSRDQTLQ 633
+ I +++ +WD +V++L S +Q Q
Sbjct: 604 SKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQ 637
Score = 49.3 bits (116), Expect = 2e-05
Identities = 68/352 (19%), Positives = 139/352 (39%), Gaps = 31/352 (8%)
Query: 423 WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL---NELD 479
W E+ ++D S ++EV+ HEAF +L AHQ V + +L L
Sbjct: 324 WLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLS 383
Query: 480 YHEAASVNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWL 539
E + + + +W+ L R ++++R +L + + +LQ + ++ + +
Sbjct: 384 DEEEFEIQEQMTLLNARWEAL------RVESMDRQSRLHDVLMELQKKQLQQLSAWLTLT 437
Query: 540 DGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLR 599
+ ++ ++ L V+ Q LL H ++ L + E+ + + + + + G
Sbjct: 438 EERIQKMETCPLDDDVKSLQKLLEEHKSLQSDL---EAEQVKVNSLTHMVVIVDENSGE- 493
Query: 600 PCSTNPYITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPW 659
S + Q + +W V + R LQE Q E L Q +A W
Sbjct: 494 --SATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQ--ELLEEQCLLKA-----W 544
Query: 660 IQAKVEEVGRLAAGLAGSLEEQMAGLRQ---QEQNIINYKTNIDRL----EGDHQLLQES 712
+ K E + ++ +E +R+ ++++ + +D+L + QLL S
Sbjct: 545 LTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNS 604
Query: 713 LVFDNKHTVYSMEHIRVGWEQLLTSIARTINEVENQVLTRDAKGLSQEQLNE 764
+K E + W+ L+ + + N+V V + Q+ L E
Sbjct: 605 KA--SKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLE 654
Score = 42.4 bits (98), Expect = 0.002
Identities = 51/252 (20%), Positives = 112/252 (44%), Gaps = 31/252 (12%)
Query: 286 NEKLMEEYEKLASELLEWIRRTVPWLENRVGEPSMSAMQRKLEDFRDYRRLHKPPRIQEK 345
++ LME +K +L W+ T E R+ + + +D + ++L ++E
Sbjct: 416 HDVLMELQKKQLQQLSAWLTLT----EERIQKMETCPLD---DDVKSLQKL-----LEEH 463
Query: 346 CQLEINFNTLQTKLR-LSHRPAFMP-SEGKLVSDIANAWRGLEQVEKGYEDWLL------ 397
L+ + Q K+ L+H + + G+ + I +Q++K E W
Sbjct: 464 KSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILE-----DQLQKLGERWTAVCRWTE 518
Query: 398 SEIRRLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDSALLQ-EVRALLRRHEAFES 456
RLQ + L ++ ++ L +AW KEE L++ + Q E+ +RR +
Sbjct: 519 ERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKE 578
Query: 457 DLAAHQDRVEHIAALAQELNELDYHEAAS--VNSRCQAICDQWDNLGTLTQKRRDALERM 514
D+ + ++ ++ + Q++ +L + AS +NS + + +WD +L Q+ D+ ++
Sbjct: 579 DMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWD---SLVQRLEDSSNQV 635
Query: 515 EKLLETIDQLQL 526
+ + + Q+
Sbjct: 636 TQAVAKLGMSQI 647
Score = 38.5 bits (88), Expect = 0.028
Identities = 60/319 (18%), Positives = 126/319 (39%), Gaps = 33/319 (10%)
Query: 428 EEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQEL-NELDYHE-AAS 485
++ML ++E+ + R + ++DL +++++ LAQ L N+ + +
Sbjct: 2246 DQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTA 2305
Query: 486 VNSRCQAICDQWDNLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVED 545
+ + + + +QWD + R+ LE M ID LQ + R + +
Sbjct: 2306 ITEKLERVKNQWDGTQHGVELRQQQLEDM-----IIDSLQWDDHREET------EELMRK 2354
Query: 546 LQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGAIMGIQGEIQKICQTYGLRPCSTNP 605
+ + L + L E G +M +QK+ + YG
Sbjct: 2355 YEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYG---SDDTR 2411
Query: 606 YITLSPQDINTKWDMVRKLVPSRDQTLQEELARQQVNERLRRQFAAQANAIGPWIQAKVE 665
+ + + + T W +++ + R L+ E Q + R F WIQ
Sbjct: 2412 NVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFL-------KWIQEAET 2464
Query: 666 EVGRL--AAGLAGSLEEQMAG--LRQQEQNI---INYKTNIDR-LEGDHQLLQESLVFDN 717
V L A+ +L++ + L+QQ Q+I I+ +I + ++G+ Q + ++L
Sbjct: 2465 TVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSE 2524
Query: 718 KHTV--YSMEHIRVGWEQL 734
+ T+ + ++ + W L
Sbjct: 2525 EATMLQHRLDDMNQRWNDL 2543
Score = 37.4 bits (85), Expect = 0.063
Identities = 92/439 (20%), Positives = 166/439 (37%), Gaps = 115/439 (26%)
Query: 279 VLAVNQENEKLMEEY----EKLASELLEWIRRTVPWLENRVGEP---------SMSAMQR 325
V+A + +KL+EEY + E E+++ + L+ + + ++ A +R
Sbjct: 2391 VMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRR 2450
Query: 326 KLEDFRDYRR------------LHKPPRIQEKC---QLEINFNTLQTKLRLSHRPAFMPS 370
LE+F + + H+ +Q+ +L+ +Q ++ +H F
Sbjct: 2451 DLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEID-AHNDIFKSI 2509
Query: 371 EG---KLVSDIANAWRG------LEQVEKGYEDWLLSEIRRLQRLQHLAEKF-RQKASLH 420
+G K+V + N+ L+ + + + D L+ AEK+ R SL
Sbjct: 2510 DGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLE 2569
Query: 421 EA--WTRGKEEMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNEL 478
E W K+E L ++ D+ A Q + +H AL +EL E
Sbjct: 2570 ELIKWLNMKDEEL-----------------KKQMPIGGDVPALQLQYDHCKALRRELKEK 2612
Query: 479 DYHEAASVNSRCQAICDQ--------WDNLGTLTQKRRDALERMEKLLETIDQLQLEFAR 530
+Y +V+ + DQ NL + T+ + ER +K+ + + + E
Sbjct: 2613 EYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPE--ERAQKIAKAMRKQSSEVKE 2670
Query: 531 RAAPFN----NW---LDGAVEDLQDVWLVHSVEETQSLLTAHDQFKATLPEADRERGA-- 581
+ N NW +D A+E L+D L A D A + EA+ R
Sbjct: 2671 KWESLNAVTSNWQKQVDKALEKLRD------------LQGAMDDLDADMKEAESVRNGWK 2718
Query: 582 ------IMGIQGEIQKICQ------------------TYGLRPCSTNPYITLSPQ--DIN 615
I +Q I+KI + L P +P + +S Q D+N
Sbjct: 2719 PVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLN 2778
Query: 616 TKWDMVRKLVPSRDQTLQE 634
+W +++ V R + LQE
Sbjct: 2779 MRWKLLQVSVDDRLKQLQE 2797
Score = 34.7 bits (78), Expect = 0.41
Identities = 33/164 (20%), Positives = 65/164 (39%), Gaps = 22/164 (13%)
Query: 373 KLVSDIANAWRGLEQVEKGYE---DWLLSEIRRLQ-RLQHLAEKFRQKASLHEAWTRGKE 428
K S++ W L V ++ D L ++R LQ + L ++ S+ W
Sbjct: 2663 KQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGW----- 2717
Query: 429 EMLSQRDYDSALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNS 488
+ L+ ++ + + AF ++A +V+ + L+ +L+ LD H + ++
Sbjct: 2718 -----KPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSR 2772
Query: 489 RCQAICDQW--------DNLGTLTQKRRDALERMEKLLETIDQL 524
+ + +W D L L + RD + L T QL
Sbjct: 2773 QLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQL 2816
Score = 33.5 bits (75), Expect = 0.91
Identities = 60/309 (19%), Positives = 126/309 (40%), Gaps = 35/309 (11%)
Query: 270 ETAANRICKVLAVNQENEKLMEEYEKLAS------ELLEWIRRTVP-WLENRVGEPSMSA 322
+T ++ K +A + +L E EK A+ E+ EW+ + +LE S
Sbjct: 1103 QTQLEKLSKEIAT--QKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEE 1160
Query: 323 MQRKLEDFRDYRRLHKPPRIQEKCQLEINFNTLQTKLRLSHRPAFMPSEGKLVSDIANAW 382
++ +E+ + + ++ Q E+ L+ ++L A +PS G+ ++ N
Sbjct: 1161 LESAVEEMKRAK--------EDVLQKEVRVKILKDNIKLL--AAKVPSGGQELTSELNV- 1209
Query: 383 RGLEQVEKGYEDWLLSEIR----RLQRLQHLAEKFRQKASLHEAWTRGKEEMLSQRDYDS 438
V + Y+ L + IR L+ + + L W EE + +
Sbjct: 1210 -----VLENYQ-LLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTE--- 1260
Query: 439 ALLQEVRALLRRHEAFESDLAAHQDRVEHIAALAQELNELDYHEAASVNSRCQAICDQWD 498
L ++ A+ E+ ES L D I L Q L + + ++ + +A +++
Sbjct: 1261 VLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDI-ISEKLEAFNSRYE 1319
Query: 499 NLGTLTQKRRDALERMEKLLETIDQLQLEFARRAAPFNNWLDGAVEDLQDVWLV-HSVEE 557
+L L + ++ +LE+ ++L DQ+ + L + D D + V ++
Sbjct: 1320 DLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQK 1379
Query: 558 TQSLLTAHD 566
Q+ ++AH+
Sbjct: 1380 IQAEISAHE 1388
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,655,013
Number of Sequences: 37866
Number of extensions: 1430336
Number of successful extensions: 6988
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 141
Number of HSP's successfully gapped in prelim test: 173
Number of HSP's that attempted gapping in prelim test: 5800
Number of HSP's gapped (non-prelim): 1056
length of query: 901
length of database: 18,247,518
effective HSP length: 111
effective length of query: 790
effective length of database: 14,044,392
effective search space: 11095069680
effective search space used: 11095069680
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.