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Search of human proteins with 45331215
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo
sapiens]
(669 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo sa... 1327 0.0
gi|7662176 ProSAPiP1 protein [Homo sapiens] 323 4e-88
gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo sa... 314 1e-85
gi|62177129 Nedd4 binding protein 3 [Homo sapiens] 196 4e-50
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 82 2e-15
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 81 3e-15
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 81 4e-15
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 81 4e-15
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 81 4e-15
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 81 4e-15
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 81 4e-15
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 81 4e-15
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 81 4e-15
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 81 4e-15
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 78 3e-14
gi|195947367 golgi autoantigen, golgin subfamily a, 8B [Homo sap... 77 4e-14
gi|31083099 golgi autoantigen, golgin subfamily a, 8A [Homo sapi... 77 4e-14
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 77 4e-14
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 77 4e-14
gi|148746195 trichohyalin [Homo sapiens] 75 1e-13
gi|239745083 PREDICTED: similar to Golgin subfamily A member 8-l... 74 4e-13
gi|239745081 PREDICTED: similar to Golgin subfamily A member 8-l... 74 4e-13
gi|221139761 zinc finger protein 853 [Homo sapiens] 73 7e-13
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 72 1e-12
gi|239745085 PREDICTED: similar to Golgin subfamily A member 8-l... 71 3e-12
gi|21735548 centrosomal protein 2 [Homo sapiens] 71 4e-12
gi|239745087 PREDICTED: similar to Golgin subfamily A member 8-l... 71 4e-12
gi|31982906 cingulin-like 1 [Homo sapiens] 70 5e-12
gi|157738667 FYVE and coiled-coil domain containing 1 [Homo sapi... 70 6e-12
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 69 1e-11
>gi|45331215 leucine zipper, putative tumor suppressor 2 [Homo
sapiens]
Length = 669
Score = 1327 bits (3434), Expect = 0.0
Identities = 669/669 (100%), Positives = 669/669 (100%)
Query: 1 MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQD 60
MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQD
Sbjct: 1 MAIVQTLPVPLEPAPEAATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQD 60
Query: 61 GLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHL 120
GLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHL
Sbjct: 61 GLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHL 120
Query: 121 RGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLT 180
RGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLT
Sbjct: 121 RGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLT 180
Query: 181 QLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTT 240
QLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTT
Sbjct: 181 QLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTT 240
Query: 241 SSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRA 300
SSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRA
Sbjct: 241 SSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRA 300
Query: 301 SPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEE 360
SPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEE
Sbjct: 301 SPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEE 360
Query: 361 RQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLER 420
RQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLER
Sbjct: 361 RQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLER 420
Query: 421 RCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALRE 480
RCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALRE
Sbjct: 421 RCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALRE 480
Query: 481 ARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREP 540
ARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREP
Sbjct: 481 ARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREP 540
Query: 541 PVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGER 600
PVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGER
Sbjct: 541 PVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGER 600
Query: 601 LAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCIC 660
LAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCIC
Sbjct: 601 LAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCIC 660
Query: 661 LEEITATEI 669
LEEITATEI
Sbjct: 661 LEEITATEI 669
>gi|7662176 ProSAPiP1 protein [Homo sapiens]
Length = 673
Score = 323 bits (827), Expect = 4e-88
Identities = 261/702 (37%), Positives = 358/702 (50%), Gaps = 128/702 (18%)
Query: 1 MAIVQTLPVPLEPA--PEAATAPQAP---------VMGSVSSLIS----------GRPCP 39
MA ++TLPV +P P A AP+ MGSV S ++ G
Sbjct: 1 MAKLETLPVRADPGRDPLLAFAPRPSELGPPDPRLAMGSVGSGVAHAQEFAMKSVGTRTG 60
Query: 40 GGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPRKAVPVTSFTYINEDFR--- 96
GG + GP G G ++E P P + + + Y+N + R
Sbjct: 61 GGGSQGSFPGPRGS-----------GSGASRER--PGRYPSEDKGLANSLYLNGELRGSD 107
Query: 97 ----------TESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPT 146
+ S S + A Q +H PPKL+ SGKL++ E L+RP+
Sbjct: 108 HTDVCGNVVGSSGGSSSSGGSDKAPPQYREPSH----PPKLLATSGKLDQCSEP-LVRPS 162
Query: 147 AFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLAFS 206
AFKPV+PK S+ + P+ G + L GG S + +
Sbjct: 163 AFKPVVPK--NFHSMQNLCPPQTNGTPEGRQGPGGLKGGLDKSRTMTP------------ 208
Query: 207 GWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTT--SSPGGHL-----PSHGSGRGALPG 259
A G SG LSDSGRNSL+SLPTYS+ ++ S+ H+ S+GSG G G
Sbjct: 209 --AGGSGSG-LSDSGRNSLTSLPTYSSSYSQHLAPLSASTSHINRIGTASYGSGSGGSSG 265
Query: 260 PARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPP 319
G + SDSGR+SS + S GR G LGSG G P PP
Sbjct: 266 GGSGYQDLGT-SDSGRASSKSGSSSSMGRP--GHLGSGEGG-------GGGLPFAACSPP 315
Query: 320 SDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQ 379
S AL+ LE +L ++E E+ LR SL+++EA + Q EERQ+ W+RE LR+ C+ +
Sbjct: 316 SPSALIQ-ELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGK 374
Query: 380 ----AQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPR 435
A+RAQRAQQ LQLQV +LQQ+K+QLQ++ A+L+++RE+LE + A ++EQ + PR
Sbjct: 375 LQQVARRAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPR 434
Query: 436 LEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGL 495
+EETKWEVCQK+GEISLLKQQLK+SQA++ QK SE+V LR LRE RA+LR E + L
Sbjct: 435 IEETKWEVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQLREGRASLREKEEQLLSL 494
Query: 496 QEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPA-TADPFLLAE 554
+++ +++ LE G+L A PV PA D E
Sbjct: 495 RDSFSSKQASLEL-----------------GEGELPAACLKPALTPVDPAEPQDALATCE 537
Query: 555 SDEAKVQRAA--------------AGVGG-----SLRAQVERLRVELQRERRRGEEQRDS 595
SDEAK++R A A GG +LR +V RL+ EL ERR E Q S
Sbjct: 538 SDEAKMRRQAGVAAAASLVSVDGEAEAGGESGTRALRREVGRLQAELAAERRARERQGAS 597
Query: 596 FEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQ 637
F ER W EKE+VI YQKQLQ +Y++MY+RN+QLE+ L++
Sbjct: 598 FAEERRVWLEEKEKVIEYQKQLQLSYVEMYQRNQQLERRLRE 639
Score = 30.8 bits (68), Expect = 4.2
Identities = 36/156 (23%), Positives = 61/156 (39%), Gaps = 6/156 (3%)
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ---R 562
++ + L QE LR Q +A A + E + L + K+Q R
Sbjct: 321 IQELEERLWEKEQEVAALRRSLEQSEAAVAQVLEERQKAWERELAELRQGCSGKLQQVAR 380
Query: 563 AAAGVGGSLRAQVERL---RVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
A L+ QV RL + +LQ E R QR+ E + A Q E+ + ++ +
Sbjct: 381 RAQRAQQGLQLQVLRLQQDKKQLQEEAARLMRQREELEDKVAACQKEQADFLPRIEETKW 440
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQ 655
Q L+Q+L+ ++ + +GL Q
Sbjct: 441 EVCQKAGEISLLKQQLKDSQADVSQKLSEIVGLRSQ 476
>gi|10440566 leucine zipper, putative tumor suppressor 1 [Homo
sapiens]
Length = 596
Score = 314 bits (805), Expect = 1e-85
Identities = 243/658 (36%), Positives = 320/658 (48%), Gaps = 76/658 (11%)
Query: 26 MGSVSSLISG-----RPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAVPPR 80
MGSVSSLISG + C R R DGLLR G+
Sbjct: 1 MGSVSSLISGHSFHSKHCRASQYKLRKSSHL-KKLNRYSDGLLRFGFSQDSG--HGKSSS 57
Query: 81 KAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGP--PPKLIPVSGKLEKNM 138
K F YI + P + + P PPKL+P S +LE
Sbjct: 58 KMGKSEDFFYIKVSQKARGSHHPDYTALSSGDLGGQAGVDFDPSTPPKLMPFSNQLEMGS 117
Query: 139 EKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSA 198
EK +RPTAFKPVLP+ SG+ + S+S +
Sbjct: 118 EKGAVRPTAFKPVLPR------------------SGA------ILHSSPESASHQLHPAP 153
Query: 199 ADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGA---EPTTSSPGGHLPSHGSGRG 255
DKP G SG LSDSGRNS+SSLPT+ST + +P + G P+ G
Sbjct: 154 PDKPKE-QELKPGLCSGALSDSGRNSMSSLPTHSTSSSYQLDPLVTPVG---PTSRFG-- 207
Query: 256 ALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPP 315
G A + G DS S + S GG G S+ ++ P
Sbjct: 208 ---GSAHNITQGIVLQDSNMMSLKALSFSDGGSKLG------------HSNKADKGPSCV 252
Query: 316 PPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALR-- 373
P S + LE KL +RE LQ+L+ S +E E AYEER R + E E
Sbjct: 253 RSPISTDECSIQELEQKLLEREGALQKLQRSFEEKELASSLAYEERPRRCRDELEGPEPK 312
Query: 374 --EDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRE 431
+Q++QRAQQ+L LQV QLQQEKRQL+ + L++E++ LE + + ERE+
Sbjct: 313 GGNKLKQASQKSQRAQQVLHLQVLQLQQEKRQLRQELESLMKEQDLLETKLRSYEREKTS 372
Query: 432 LGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGR 491
GP LEET+WEVCQKSGEISLLKQQLKESQ E+ K SE++ L+ L++ R L E R
Sbjct: 373 FGPALEETQWEVCQKSGEISLLKQQLKESQTEVNAKASEILGLKAQLKDTRGKLEGLELR 432
Query: 492 ARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
+ L+ A R + LELE C ELQR + EAE LREK L+ E LR P
Sbjct: 433 TQDLEGALRTKGLELEVCENELQRKKNEAELLREKVNLLEQELQELRAQAALARDMGPPT 492
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVI 611
E A L+ ++ERLR EL+ ER+ ++ F+ ERL W+ EKE+VI
Sbjct: 493 FPEDVPA------------LQRELERLRAELREERQGHDQMSSGFQHERLVWKEEKEKVI 540
Query: 612 RYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI 669
+YQKQLQ +Y+ MY+RN++LE+ LQQL+ A E ++ L + I E+I ATEI
Sbjct: 541 QYQKQLQQSYVAMYQRNQRLEKALQQLARGDSAGEPLEVDL--EGADIPYEDIIATEI 596
>gi|62177129 Nedd4 binding protein 3 [Homo sapiens]
Length = 544
Score = 196 bits (499), Expect = 4e-50
Identities = 194/625 (31%), Positives = 263/625 (42%), Gaps = 104/625 (16%)
Query: 18 ATAPQAPVMGSVSSLISGRPCPGGPAPPRHHGPPGPTFFRQQDGLLRGGYEAQEPLCPAV 77
A P MGSV SL+ + G G RQ DGLLR G +E L
Sbjct: 4 APGPAGIAMGSVGSLLERQDFSPEELRAALAGSRGS---RQPDGLLRKGLGQREFLSYLH 60
Query: 78 PPRKAVPVTSFTYINEDFRTESPPSPSSDVEDAREQRAHNAHLRGPPPKLIPVSGKLEKN 137
P+K T N + P+ + + RA + P +
Sbjct: 61 LPKKDSKSTK----NTKRAPRNEPADYATLYYREHSRAGDFSKTSLPER---------GR 107
Query: 138 MEKILIRPTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSS 197
+K IRP+ FKP +G S+ S + L S GSL L P S +S +
Sbjct: 108 FDKCRIRPSVFKPTAGNGKGFLSMQSLASHKGQKLWRSNGSLHTLACHPPLSPGPRASQA 167
Query: 198 AADKPLAFSGWASGCPSGTLSDSGRNSLSSLPTYSTGGAEPTTSSPGGHLPSHGSGRGAL 257
A A S GG EP S S G G
Sbjct: 168 RAQLLHALS------------------------LDEGGPEPEPSLSDS---SSGGSFGRS 200
Query: 258 PGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPP 317
PG TGPS SSS LGG + G P SC P PP
Sbjct: 201 PG------TGPSPF----SSSLGHLNHLGGSLDRASQGPKEAGPPAVLSC-----LPEPP 245
Query: 318 PPSDEALLHCVLEGKLRDREAELQQLRDSLDENEAT--MCQAYEERQRHWQREREALR-E 374
PP + + G + E +L+ L + + + Q EERQR W E + L E
Sbjct: 246 PPYEFSCSSAEEMGAVLPETCE--ELKRGLGDEDGSNPFTQVLEERQRLWLAELKRLYVE 303
Query: 375 DCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGP 434
Q+A+R+++ LQLQ+F QQE+R+L+ + + Q R TL P
Sbjct: 304 RLHEVTQKAERSERNLQLQLFMAQQEQRRLRKEL-RAQQGLAPEPRAPGTLPEADPSARP 362
Query: 435 RLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARG 494
EE +WEVCQK+ EISLLKQQL+E+QAEL QK +E+ +L+ LR +RA
Sbjct: 363 E-EEARWEVCQKTAEISLLKQQLREAQAELAQKLAEIFSLKTQLRGSRA----------- 410
Query: 495 LQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE 554
+ +A EL R R+ L+E+A + +A + E
Sbjct: 411 ----------QAQAQDAELVRLREAVRSLQEQAPREEAPGS-----------------CE 443
Query: 555 SDEAKVQRAAAGVGGS-LRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRY 613
+D+ K + GGS R E+LR EL +ER RG+EQ FE ER WQ EKE+V+RY
Sbjct: 444 TDDCKSRGLLGEAGGSEARDSAEQLRAELLQERLRGQEQALRFEQERRTWQEEKERVLRY 503
Query: 614 QKQLQHNYIQMYRRNRQLEQELQQL 638
Q+++Q Y+ MYRRN+ LEQEL+ L
Sbjct: 504 QREIQGGYMDMYRRNQALEQELRAL 528
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 81.6 bits (200), Expect = 2e-15
Identities = 108/406 (26%), Positives = 172/406 (42%), Gaps = 48/406 (11%)
Query: 269 SHSDSG-RSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGE-RSPPPPPPPPSDEALLH 326
S S+SG + S S+ T GL G T + P SS G RSP P P ++
Sbjct: 462 SDSESGVQLSGSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTL 521
Query: 327 CVLEGKLRDREAELQQ--------------LRDSLDENEATMCQAYEERQRHWQREREAL 372
++ L R+ ++Q LR L ++E+ E+ QR + A+
Sbjct: 522 ALIHSALHKRQLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAM 581
Query: 373 R--EDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQR 430
+ ED + QR + A +LL + L + Q +L QERE+L+ L R++
Sbjct: 582 QAHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQR- 640
Query: 431 ELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQ---KGSELVALRVALREA--RATL 485
RLEE + + Q + +++L+ S +L Q K S L V +REA RATL
Sbjct: 641 ---DRLEEEQEDAVQDGARV---RRELERSHRQLEQLEGKRSVLAKELVEVREALSRATL 694
Query: 486 RVSEGRARGLQEA-----ARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREP 540
+ +A + A A A +ELE +L R E L++ +L A L +
Sbjct: 695 QRDMLQAEKAEVAEALTKAEAGRVELELSMTKL---RAEEASLQDSLSKLSALNESLAQD 751
Query: 541 PVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGER 600
+ L+A+ +E K + + G R Q E+ + E+ R EE R E R
Sbjct: 752 KLDLNR----LVAQLEEEK-----SALQGRQR-QAEQEATVAREEQERLEELRLEQEVAR 801
Query: 601 LAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARE 646
+ + Q+ L+ + QL+++L QLS +L RE
Sbjct: 802 QGLEGSLRVAEQAQEALEQQLPTLRHERSQLQEQLAQLSRQLSGRE 847
Score = 78.2 bits (191), Expect = 2e-14
Identities = 96/353 (27%), Positives = 156/353 (44%), Gaps = 48/353 (13%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
L +L + ++ LQ R E EAT+ + +ER + E+E R+ + A++AQ+
Sbjct: 758 LVAQLEEEKSALQG-RQRQAEQEATVAREEQERLEELRLEQEVARQGLEGSLRVAEQAQE 816
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
L+ Q+ L+ E+ QLQ+ AQL QL R LE+ +RE
Sbjct: 817 ALEQQLPTLRHERSQLQEQLAQL---SRQLSGREQELEQARRE--------------AQR 859
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ L++ +E +A + V L A RE R TL R R +EA E++
Sbjct: 860 QVEALERAAREKEALAKEHAGLAVQLVAAEREGR-TLSEEATRLRLEKEALEGSLFEVQR 918
Query: 509 CSQELQRHRQ----EAEQLREKAGQLDAEAAGLREPPV---PPATADPFLLAESDEAKVQ 561
+L+ R+ E + L L E AGLR+ + A+ D L+A+ K+
Sbjct: 919 QLAQLEARREQLEAEGQALLLAKETLTGELAGLRQQIIATQEKASLDKELMAQ----KLV 974
Query: 562 RAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNY 621
+A SLR Q +LQR +R E AW+ + + + Q QLQ
Sbjct: 975 QAEREAQASLREQRAAHEEDLQRLQREKE----------AAWRELEAERAQLQSQLQREQ 1024
Query: 622 IQMYRRNRQLEQELQQLSLELEA-RELADLGL----AEQAPCICLEEITATEI 669
++ R LE E ++LS E+ A ++ D GL +E+ + L+E T +
Sbjct: 1025 EELLAR---LEAEKEELSEEIAALQQERDEGLLLAESEKQQALSLKESEKTAL 1074
Score = 58.5 bits (140), Expect = 2e-08
Identities = 98/359 (27%), Positives = 147/359 (40%), Gaps = 68/359 (18%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
LE + + R+A+ +Q +D N T E R QRE A AA AQ +R
Sbjct: 1090 LEMERQKRDAQSRQEQDRSTVNALTS----ELRDLRAQREEAA-----AAHAQEVRR--- 1137
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLE-------REQRELGPRLEETK- 440
LQ++ R L L+E E+L + LE RE E +L E++
Sbjct: 1138 --------LQEQARDLGKQRDSCLREAEELRTQLRLLEDARDGLRRELLEAQRKLRESQE 1189
Query: 441 ---------WEVCQKSGEISLLKQQLKESQAEL---VQKG-SELVALRVA---------- 477
E+ + GE + ++ L+ S EL V+K SE ++L++A
Sbjct: 1190 GREVQRQEAGELRRSLGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLAL 1249
Query: 478 LREARATLRVSEGRAR-GLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAG 536
L EAR + G R GLQE R+R LEA +ELQ R++ + L + +L E A
Sbjct: 1250 LEEARTAVGKEAGELRTGLQEVERSR---LEA-RRELQELRRQMKMLDSENTRLGRELAE 1305
Query: 537 LREPPVPPATADPFLLAESDEAKVQRAAAGVGGSL---RAQVERLRVELQRERRRGEEQR 593
L+ L E E + +R G+ L A +E +R ELQ +R+ +EQ
Sbjct: 1306 LQ---------GRLALGERAEKESRRETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQE 1356
Query: 594 DSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
F E+ +KQ + + + E +L L L A E GL
Sbjct: 1357 GEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAARAEAAELGLRLSAAEGRAQGL 1415
Score = 56.2 bits (134), Expect = 9e-08
Identities = 101/441 (22%), Positives = 174/441 (39%), Gaps = 67/441 (15%)
Query: 251 GSGRGALPGPA-RGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGE 309
G G G P PA R VP P+ S G G SP + C
Sbjct: 1443 GLGLGRAPSPAPRPVPGSPARDAPAEGS-----------------GEGLN-SPSTLECSP 1484
Query: 310 RSPPPPPPP---PSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQ 366
S PP P P P+ L + G LR+ EL+ + DE T A + +
Sbjct: 1485 GSQPPSPGPATSPASPDLDPEAVRGALREFLQELRSAQRERDELR-TQTSALNRQLAEME 1543
Query: 367 REREALR------EDCAAQAQRAQRAQQL----LQLQVFQLQQEKRQLQDDFAQLLQERE 416
ER++ + A+++ A+R+ +Q ++ ++ R+ + + L +
Sbjct: 1544 AERDSATSRARQLQKAVAESEEARRSVDGRLSGVQAELALQEESVRRSERERRATLDQVA 1603
Query: 417 QLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV 476
LER E E R ++ + K + G+ LK+ L S++ V+ + +L
Sbjct: 1604 TLERSLQATESELRASQEKISKMKANETKLEGDKRRLKEVLDASESRTVKLELQRRSLEG 1663
Query: 477 ALREARATLRVSEGRARGLQEAA-----RARELELEACSQEL--QRHRQEAEQLREKAGQ 529
L+ +R L E +A+ LQ+ + + E++A + +L +R ++ E G
Sbjct: 1664 ELQRSRLGLSDREAQAQALQDRVDSLQRQVADSEVKAGTLQLTVERLNGALAKVEESEGA 1723
Query: 530 LDAEAAGLREPPVPPATADPFLLAESDE-AKVQRAAAGVGGSLRAQVERL---RVELQRE 585
L + GL E A + L + D+ +Q+A + ERL R L
Sbjct: 1724 LRDKVRGLTE---ALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQERLDAARQALSEA 1780
Query: 586 RRRGE---EQRDSFEGE-------RLAWQAEKEQVIRYQKQLQH------NYIQMYRRNR 629
R++ EQ + GE R+ + + +Q+ +Q Q N +Q + R
Sbjct: 1781 RKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAAALNTVQKLQDER 1840
Query: 630 QLEQE----LQQLSLELEARE 646
+L QE LQ+ +LEA +
Sbjct: 1841 RLLQERLGSLQRALAQLEAEK 1861
Score = 53.5 bits (127), Expect = 6e-07
Identities = 75/283 (26%), Positives = 121/283 (42%), Gaps = 31/283 (10%)
Query: 331 GKLRD---REAE-----LQQLRDSLDENEATMCQAYEERQRHWQREREALREDC------ 376
GK RD REAE L+ L D+ D + +A + + R Q RE R++
Sbjct: 1146 GKQRDSCLREAEELRTQLRLLEDARDGLRRELLEA-QRKLRESQEGREVQRQEAGELRRS 1204
Query: 377 ----AAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQREL 432
A + + +R+ + L+ V + + E+ L+ Q+ LE + +E EL
Sbjct: 1205 LGEGAKEREALRRSNEELRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGEL 1264
Query: 433 GPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRA 492
L+E + + E+ L++Q+K +E + G EL L+ L + S
Sbjct: 1265 RTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESRRET 1324
Query: 493 RGLQEAARARELELEACSQEL---QRHRQEAE-----QLREKAGQLDAEAAGLREPPVPP 544
GL++ E LE QEL QR QE E + R G L+ EA G + +
Sbjct: 1325 LGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLE-EARGTEKQQLDH 1383
Query: 545 ATADPFLL--AESDEAKV-QRAAAGVGGSLRAQVERLRVELQR 584
A L A ++ A++ R +A G + + E RVE+QR
Sbjct: 1384 ARGLELKLEAARAEAAELGLRLSAAEGRAQGLEAELARVEVQR 1426
Score = 49.3 bits (116), Expect = 1e-05
Identities = 62/250 (24%), Positives = 106/250 (42%), Gaps = 36/250 (14%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQ 398
++Q LR + + E +A + Q+ RE LR+ +A Q+L Q + LQ
Sbjct: 1790 QVQTLRGEVADLELQRVEA----EGQLQQLREVLRQRQEGEAAALNTVQKL-QDERRLLQ 1844
Query: 399 QEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLK 458
+ LQ AQL E+ ++ER LE+++ L L++ + E + + L
Sbjct: 1845 ERLGSLQRALAQLEAEKREVERSALRLEKDRVALRRTLDKVEREKLRSHEDTVRL----- 1899
Query: 459 ESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQ 518
AE + L + L EA+ ++ E + L+++ +LE++A Q+L+ +Q
Sbjct: 1900 --SAEKGRLDRTLTGAELELAEAQRQIQQLEAQVVVLEQSHSPAQLEVDAQQQQLEL-QQ 1956
Query: 519 EAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERL 578
E E+LR Q + L + A QR L QV L
Sbjct: 1957 EVERLRSAQAQTER------------------TLEARERAHRQRVR-----GLEEQVSTL 1993
Query: 579 RVELQRERRR 588
+ +LQ+E RR
Sbjct: 1994 KGQLQQELRR 2003
Score = 48.9 bits (115), Expect = 1e-05
Identities = 88/372 (23%), Positives = 142/372 (38%), Gaps = 62/372 (16%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQ---------RHWQREREALREDCAAQ 379
L ++ E+E L+ + ++ E + E R R +E E R + +
Sbjct: 1222 LRSAVKKAESERISLKLANEDKEQKLALLEEARTAVGKEAGELRTGLQEVERSRLEARRE 1281
Query: 380 AQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEET 439
Q +R ++L + +L +E +LQ A L ER + E R TL QR L E
Sbjct: 1282 LQELRRQMKMLDSENTRLGRELAELQGRLA--LGERAEKESRRETLGLRQRLLKG---EA 1336
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVA------------------LRVALREA 481
EV ++ E+ + +++L+E + E + L+ L + L A
Sbjct: 1337 SLEVMRQ--ELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQLDHARGLELKLEAA 1394
Query: 482 RAT-------LRVSEGRARGLQE-------AARARELELEACSQELQR----HRQEAEQL 523
RA L +EGRA+GL+ RA E +L L+R R +
Sbjct: 1395 RAEAAELGLRLSAAEGRAQGLEAELARVEVQRRAAEAQLGGLRSALRRGLGLGRAPSPAP 1454
Query: 524 REKAGQ--LDAEAAGLREPPVPPATAD-------PFLLAESDEAKVQRAAAGVGGSLRAQ 574
R G DA A G E P+T + P + A V G+LR
Sbjct: 1455 RPVPGSPARDAPAEGSGEGLNSPSTLECSPGSQPPSPGPATSPASPDLDPEAVRGALREF 1514
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
++ LR QRER Q + + +AE++ +QLQ + R ++
Sbjct: 1515 LQELR-SAQRERDELRTQTSALNRQLAEMEAERDSATSRARQLQKAVAESEEARRSVDGR 1573
Query: 635 LQQLSLELEARE 646
L + EL +E
Sbjct: 1574 LSGVQAELALQE 1585
Score = 44.7 bits (104), Expect = 3e-04
Identities = 77/363 (21%), Positives = 142/363 (39%), Gaps = 63/363 (17%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
LE + R E ELQ+ R L + EA QA ++R QR+ D +A Q +
Sbjct: 1654 LELQRRSLEGELQRSRLGLSDREA-QAQALQDRVDSLQRQVA----DSEVKAGTLQLTVE 1708
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQ--------------LERRCATLEREQRELGP 434
L + ++++ + L+D L + Q L++ E +++ L
Sbjct: 1709 RLNGALAKVEESEGALRDKVRGLTEALAQSSASLNSTRDKNLHLQKALTACEHDRQVLQE 1768
Query: 435 RLEETKWEVCQKSGEISLLKQQLKESQAEL-------VQKGSELVALRVALREARATLRV 487
RL+ + + + + S L +Q++ + E+ V+ +L LR LR+ +
Sbjct: 1769 RLDAARQALSEARKQSSSLGEQVQTLRGEVADLELQRVEAEGQLQQLREVLRQRQEGEAA 1828
Query: 488 SEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATA 547
+ + LQ+ R + L + + L + E ++ A +L+ + LR T
Sbjct: 1829 ALNTVQKLQDERRLLQERLGSLQRALAQLEAEKREVERSALRLEKDRVALRR------TL 1882
Query: 548 DPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQR---ERRRGEEQRDSFEGERLAWQ 604
D KV+R LR+ + +R+ ++ +R + + E +R Q
Sbjct: 1883 D----------KVERE------KLRSHEDTVRLSAEKGRLDRTLTGAELELAEAQRQIQQ 1926
Query: 605 AEKEQVIRYQK--------QLQHNYIQMYRRNRQLEQELQQLSLELEARELAD----LGL 652
E + V+ Q Q +++ + +L Q LEARE A GL
Sbjct: 1927 LEAQVVVLEQSHSPAQLEVDAQQQQLELQQEVERLRSAQAQTERTLEARERAHRQRVRGL 1986
Query: 653 AEQ 655
EQ
Sbjct: 1987 EEQ 1989
Score = 43.9 bits (102), Expect = 5e-04
Identities = 80/372 (21%), Positives = 149/372 (40%), Gaps = 35/372 (9%)
Query: 322 EALLHCVLEGKLRD---REAELQQLRDSLDENEATMCQAYEERQRHWQR-EREALREDCA 377
+ALL LE +LRD RE +L Q + D ++A + E +R E++ L +D
Sbjct: 360 QALLQAQLEEQLRDKVLREKDLAQQQMQSDLDKADLSARVTELGLAVKRLEKQNLEKD-Q 418
Query: 378 AQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLE 437
++ + L L++ QE+ L+ + + LQ Q R A E G +L
Sbjct: 419 VNKDLTEKLEALESLRL----QEQAALETEDGEGLQ---QTLRDLAQAVLSDSESGVQLS 471
Query: 438 ETKWEVCQKSGEISLLKQQLKESQAELVQKG----------------SELVALRVALREA 481
++ +G + L Q S G S L + AL +
Sbjct: 472 GSERTADASNGSLRGLSGQRTPSPPRRSSPGRGRSPRRGPSPACSDSSTLALIHSALHKR 531
Query: 482 RATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKA-GQLDAEAAGLREP 540
+ ++ GR Q+ +L E + ++ ++LR+K G + A RE
Sbjct: 532 QLQVQDMRGRYEASQDLLGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQAHEDAQREV 591
Query: 541 PVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRV---ELQRERRRGEEQRDSFE 597
+ + +S+ A + A LR + E+L+ EL+R+R R EE+++
Sbjct: 592 QRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDRLEEEQEDAV 651
Query: 598 GERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAP 657
+ + E E+ R +QL+ + + ++ + L + +L+ R++ AE A
Sbjct: 652 QDGARVRRELERSHRQLEQLEGKRSVLAKELVEVREALSRATLQ---RDMLQAEKAEVAE 708
Query: 658 CICLEEITATEI 669
+ E E+
Sbjct: 709 ALTKAEAGRVEL 720
Score = 42.7 bits (99), Expect = 0.001
Identities = 63/266 (23%), Positives = 113/266 (42%), Gaps = 37/266 (13%)
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISL---L 453
LQQE +++D AQ ER++L + + E+ E RLE + E + G + L
Sbjct: 86 LQQELSRVEDLLAQSRAERDELAIKYNAVS-ERLEQALRLEPGELETQEPRGLVRQSVEL 144
Query: 454 KQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQEL 513
++QL+E QA +K L A + + ++ +G+ LQ R ELE Q L
Sbjct: 145 RRQLQEEQASYRRK---LQAYQEGQQRQAQLVQRLQGKI--LQYKKRCSELE----QQLL 195
Query: 514 QRHRQ-EAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLR 572
+R + E ++LR+ D E+A L+ +E + + A V LR
Sbjct: 196 ERSGELEQQRLRDTEHSQDLESA---------------LIRLEEEQQRSASLAQVNAMLR 240
Query: 573 AQVER-------LRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMY 625
Q+++ L ++++ R E AW+ E+E Y + ++
Sbjct: 241 EQLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNAYFSNEHSRLLLLW 300
Query: 626 RRNRQLEQELQQLSLELEARELADLG 651
R+ + + ++ + E R+L LG
Sbjct: 301 RQVVGFRRLVSEVKMFTE-RDLLQLG 325
Score = 41.2 bits (95), Expect = 0.003
Identities = 84/337 (24%), Positives = 152/337 (45%), Gaps = 48/337 (14%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQ 391
+L E E Q+ R L + + +E Q ++R+ +A +E QAQ QR LQ
Sbjct: 123 RLEPGELETQEPR-GLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQR----LQ 177
Query: 392 LQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGP---RLEETKWEVCQKSG 448
++ Q ++ +L+ QLL+ +LE++ ++L RLEE + Q+S
Sbjct: 178 GKILQYKKRCSELEQ---QLLERSGELEQQRLRDTEHSQDLESALIRLEEEQ----QRSA 230
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALRE-------ARATLRVSEGRARGLQEAARA 501
++ + L+E +L Q GS AL +R+ R L E R +E+ A
Sbjct: 231 SLAQVNAMLRE---QLDQAGSANQALSEDIRKVTNDWTRCRKELEHREAAWRREEESFNA 287
Query: 502 -------RELELEACSQELQRHRQEAEQLREK-----AGQLDAEAAGLREPPVPPATADP 549
R L L +R E + E+ G+L + ++E + +T
Sbjct: 288 YFSNEHSRLLLLWRQVVGFRRLVSEVKMFTERDLLQLGGELARTSRAVQEAGLGLSTG-- 345
Query: 550 FLLAES-DEAKVQRAAAGVGGSLRAQV-ERLRVELQRERRRGEEQRDSFEGERLAWQAEK 607
LAES EA +++ A L+AQ+ E+LR ++ RE+ ++Q S + ++ A
Sbjct: 346 LRLAESRAEAALEKQAL-----LQAQLEEQLRDKVLREKDLAQQQMQS-DLDKADLSARV 399
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQL-SLELE 643
++ K+L+ ++ + N+ L ++L+ L SL L+
Sbjct: 400 TELGLAVKRLEKQNLEKDQVNKDLTEKLEALESLRLQ 436
Score = 37.7 bits (86), Expect = 0.035
Identities = 49/202 (24%), Positives = 91/202 (45%), Gaps = 17/202 (8%)
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
E S+L Q+ +L Q +++ +L +RE T +S+ + L A L +
Sbjct: 23 ESSVLCQEKGLGARDLAQD-AQITSLPALIREI-VTRNLSQPESPVLLPATEMASLL--S 78
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
+E Q +QE ++ + Q AE L + + ++++A
Sbjct: 79 LQEENQLLQQELSRVEDLLAQSRAERDELA------------IKYNAVSERLEQALRLEP 126
Query: 569 GSLRAQVERLRVELQRE-RRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRR 627
G L Q R V E RR+ +E++ S+ + A+Q +++ + ++LQ +Q +R
Sbjct: 127 GELETQEPRGLVRQSVELRRQLQEEQASYRRKLQAYQEGQQRQAQLVQRLQGKILQYKKR 186
Query: 628 NRQLEQELQQLSLELEARELAD 649
+LEQ+L + S ELE + L D
Sbjct: 187 CSELEQQLLERSGELEQQRLRD 208
Score = 35.8 bits (81), Expect = 0.13
Identities = 54/215 (25%), Positives = 85/215 (39%), Gaps = 42/215 (19%)
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAREL---EL 506
+ L++QL +S++E +L LR + ++ E R +Q A EL E
Sbjct: 549 LGTLRKQLSDSESERRALEEQLQRLR---DKTDGAMQAHEDAQREVQRLRSANELLSREK 605
Query: 507 EACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAG 566
+ LQ +Q+AE+LR++ +L A LR L E E VQ A
Sbjct: 606 SNLAHSLQVAQQQAEELRQEREKLQAAQEELRR--------QRDRLEEEQEDAVQDGA-- 655
Query: 567 VGGSLRAQVERLRVELQRERRRGEEQRDSFEGER--LAWQAEKEQVIRYQKQLQHNYIQM 624
R+R EL+R R Q + EG+R LA + + + + LQ + +Q
Sbjct: 656 ----------RVRRELERSHR----QLEQLEGKRSVLAKELVEVREALSRATLQRDMLQA 701
Query: 625 YRRN----------RQLEQELQQLSLELEARELAD 649
+ ++E EL L E L D
Sbjct: 702 EKAEVAEALTKAEAGRVELELSMTKLRAEEASLQD 736
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 81.3 bits (199), Expect = 3e-15
Identities = 122/503 (24%), Positives = 216/503 (42%), Gaps = 68/503 (13%)
Query: 178 SLTQLFGGPASSSSSSSSSSAADKPLAFSGWASGCPSGTLSDSGRNSLSSL-PTYSTGGA 236
S Q+F A ++S + S+A K L GT + + + L L P +
Sbjct: 92 SQIQVFEDGADTTSPETPDSSASKVLK--------REGTDTTAKTSKLRGLKPKKAPTAR 143
Query: 237 EPTTSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDS-GRSSSSKSTGSLGGRVAGGLLG 295
+ TT P P+ GA GPS S S G SSS+ + +A ++
Sbjct: 144 KTTTRRPKPTRPASTGVAGASSS------LGPSGSASAGELSSSEPSTPAQTPLAAPIIP 197
Query: 296 SGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMC 355
+ SP + PP P P +E L ++RD E +L+ LR E++A +
Sbjct: 198 TPVLTSPGAV------PPLPSPSKEEEGL-----RAQVRDLEEKLETLRLKRAEDKAKLK 246
Query: 356 QAYE-----ERQRHWQREREALREDCAAQAQRAQR-AQQLLQLQVFQLQQEKRQLQDDFA 409
+ + E+ + W+ + + + D + + A++ A++ L+ + + +E D
Sbjct: 247 ELEKHKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKE-RYMEEMADTADAIE 305
Query: 410 QLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGS 469
++E E R +L++E L R++E L L+ +AE+ +KGS
Sbjct: 306 MATLDKEMAEERAESLQQEVEALKERVDE--------------LTTDLEILKAEIEEKGS 351
Query: 470 ELVALRVALR---EARATLRVSEGRARGLQEAARARELEL----EACSQELQRHRQEAEQ 522
+ A L+ E A L+ + R R L + + ++L E +QEL+ RQ+ E+
Sbjct: 352 DGAASSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRER 411
Query: 523 LREKAGQLDAEAAGLREPPVPPATADPFLLAESD-----EAKVQRAAAGVGGSLRAQVER 577
L+E+ Q ++ L+E A+ + +D E KV+ VG L A E
Sbjct: 412 LQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVG-DLEAMNE- 469
Query: 578 LRVELQRERRRGE-EQRDSFE--GERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
+ ELQ R E E R+ + G R+ E ++ + ++ +Y Q ++ RQL
Sbjct: 470 MNDELQENARETELELREQLDMAGARVR---EAQKRVEAAQETVADYQQTIKKYRQLTAH 526
Query: 635 LQQLSLELEARELADLGLAEQAP 657
LQ ++ EL ++ A + +Q P
Sbjct: 527 LQDVNRELTNQQEASVERQQQPP 549
Score = 32.7 bits (73), Expect = 1.1
Identities = 31/109 (28%), Positives = 42/109 (38%), Gaps = 25/109 (22%)
Query: 98 ESPPSPSSDV--EDAREQRAHNAHLRGPPPKLIPVSGKLEKNMEKILIRPTAFKPVLPKP 155
E+P S +S V + + A + LRG PK P + K PKP
Sbjct: 107 ETPDSSASKVLKREGTDTTAKTSKLRGLKPKKAPTARKTTTRR--------------PKP 152
Query: 156 RGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLA 204
P +TG++G+ SL A SSS S+ A PLA
Sbjct: 153 TR---------PASTGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLA 192
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 28/328 (8%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL--REDCAAQAQRAQRAQQL 389
+L + EA L++ R + + QA E + QR +E + RE+ A AQ+ +R+ Q
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+LQQ ++ + + ++ E ER +E E R + +LE T+ + GE
Sbjct: 1421 ------ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE----GRARGLQEAARARELE 505
+ L+ + +E++A+ Q E LR +++ R +E R + EAAR ++
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQRA 563
L+A L+ R +AE+ + Q + E A R+ V TA AE S A
Sbjct: 1535 LQA----LEELRLQAEEAERRLRQAEVERA--RQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 564 AAGVGGSLRAQ---VERLRVELQR---ERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL 617
A + SL+ + V +LR E +R ++ E R+ E E WQ + + +R +L
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RL 1646
Query: 618 QHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q + + Q E E Q+ E EAR
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/336 (29%), Positives = 151/336 (44%), Gaps = 41/336 (12%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMC--QAYEERQRHW--QREREALREDCAAQAQRAQR 385
E + EAE + R L NEA QA E Q+ Q E E +E+ +A+R +
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 386 AQQLLQLQVFQLQQE---KRQLQDDFAQ--LLQEREQLERRCATLEREQRELGPRLEETK 440
A++ Q +QE +RQL + AQ L E+E + R T + EQ+ LEE
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR--QLLEE-- 1734
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV----ALREARATLRVSEGRARGLQ 496
E+ + E + Q+ +E +AEL + +E+ L A E+R+T S+ R
Sbjct: 1735 -ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-- 1791
Query: 497 EAARAREL-----ELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
EA R REL L A ++E +R RQ AE E A + AEA + + L
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAE---EDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG---ERLA-WQAEK 607
E++ A ++ A ++ RL + +RRR EEQ + ERLA +
Sbjct: 1849 KTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
+ + QK L + + R+ RQ+E+E+ L E
Sbjct: 1903 DSELERQKGLVEDTL---RQRRQVEEEILALKASFE 1935
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 42/342 (12%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
++ L E +Q + +L+E E + E R+ + E+E+ R+ AQ +R Q
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ F +QQ++++LQ Q +QL R E + + E Q
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ ++LK+S E Q ++ A LR + +E A +A +A + +A
Sbjct: 2110 QVE-EAERLKQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQA 2162
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
E+++H++ AEQ + Q++ E LR L E+D K
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLR-----------LQLEETDHQK--------- 2202
Query: 569 GSLRAQVERLR---VELQRERRRGEE-------QRDSFEGERLAWQAEKEQVIRYQKQLQ 618
L +++RL+ E R+R + EE Q + + +AE +I K
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 619 HNYIQ-MYRRNRQLEQELQQLSLELE----ARELADLGLAEQ 655
++Q + +Q+ +E +LS+ + R+LA+ LA+Q
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/377 (23%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 333 LRDREAELQQLRDSLD------ENEATMCQAYEERQRHWQRERE------ALREDCAAQA 380
LRD++ + L++ + E A + A +E R Q E AL E +
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA--------TLERE---Q 429
+A + L+ + LQQ+K Q+ +L +++EQ+ ++ A TLE E Q
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATL---- 485
E+ E K V + S + ++ + + + + G +L +A +E + TL
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTL 2434
Query: 486 ----RVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREP 540
+ S+ A L+EA E E E QE + + ++E+++ + QL E L++
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 541 PVPPATADPFL----LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-- 594
+ + D L E ++AK+++ + A+ ++LR E QR++++ E++R
Sbjct: 2495 FL--SEKDSLLQRERFIEQEKAKLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 595 --SFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
S E R +E V R Q++LQ Q ++ L +E Q+L +L+ E
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-----E 2603
Query: 653 AEQAPCICLEEITATEI 669
+A EE+TA+++
Sbjct: 2604 QHRAALAHSEEVTASQV 2620
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 49/350 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
L+++EAE ++LR L E+EA + EE+ + + E +R QL +
Sbjct: 1856 LKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIE-------------ERLAQLRKA 1901
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEV--CQKSGEI 450
+L+++K ++D L++R Q+E L+ + E + E+ + + E
Sbjct: 1902 SDSELERQKGLVEDT----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE--- 507
+L ++ QAEL +A R A RV + A +EAAR R+ LE
Sbjct: 1958 TLRSKE----QAELEAARQRQLAAEEERRRREAEERVQKSLAAE-EEAARQRKAALEEVE 2012
Query: 508 ---ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAA 564
A +E +R R+ AEQ + QL EAA R A A E + + +
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072
Query: 565 AGVGGSLRAQVERLR--------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ 616
V LR + E R +Q ER + +R E ERL AE++ R Q Q
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 617 -----LQHNYIQMYRRNRQLEQ----ELQQLSLELEA-RELADLGLAEQA 656
L+ Q R Q EQ + Q E+E ++ A+ L ++A
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/351 (24%), Positives = 157/351 (44%), Gaps = 29/351 (8%)
Query: 336 REAELQQL-------RDSLDENEATMCQAYEERQR-------HWQREREALREDCAAQAQ 381
R+ EL+QL R+S D A + A +++ Q RE LR++ A +
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKW 441
+ +++ + Q F +Q ++D QL+ + QLE + ++ + + G ++
Sbjct: 1258 IERHGEKVEECQRFA-KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1316
Query: 442 -EVCQKSGEISLLKQQLKESQAELVQKGSELVAL----RVALREARATLRVSEGRARGLQ 496
++ E++ L Q + +E +++ E L R RE A + + + R L
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1376
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
EA + + E ++ELQ+ QE E +R + +DA+ ++ + +E++
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAE 1432
Query: 557 -EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK 615
+AK ++A A LR + E V LQ E E QR EGE A +A E+ ++
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQLEAT--ERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 616 QLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLA--EQAPCICLEEI 664
Q Q ++ R+ + Q +Q +EL +R A+ A +Q LEE+
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Score = 50.4 bits (119), Expect = 5e-06
Identities = 77/337 (22%), Positives = 147/337 (43%), Gaps = 27/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +R RE Q+L E T Q+ E+E +R A+ ++ ++ +QL
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA-------QQRLAAEQELIR--LRAETEQGEQQRQL 1731
Query: 390 LQLQVFQLQQEK----RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
L+ ++ +LQ+E ++ Q+ A+L + R ++E A+ R + E E++K +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 446 KSGEISLLKQQLKESQAELVQ-KGSELVALRVALREARATLRVSEGRARGLQEAARAR-- 502
++G L ++ +A + K +A A R+ RV + + EA R +
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 503 -ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E+ L+ E +R R+ AE + +L+ +AA + + A L ++ +++++
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA-QHKADIEERLAQ---LRKASDSELE 1907
Query: 562 RAAAGVGGSL--RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
R V +L R QVE + L+ + + E E ++ E +R ++Q +
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQA 656
R RQL E ++ E E R L E+A
Sbjct: 1968 E----AARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000
Score = 44.3 bits (103), Expect = 4e-04
Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 26/265 (9%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALREDCAAQAQR 382
+L+ E + Q L E +A E+ QRER E L +D A+AQ+
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+ QQ Q Q ++QE+++L + + + + E + E ++L + + +
Sbjct: 2530 LREEQQRQQQQ---MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ + Q L+E + E+ A +VA AT + GR AA
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA-----ATKTLPNGRDALDGPAA--- 2638
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E E L+R + A++L+E AG L AE L+ T D E +Q
Sbjct: 2639 EAEPEHSFDGLRR-KVSAQRLQE-AGILSAEE--LQRLAQGHTTVDELARREDVRHYLQG 2694
Query: 563 AAAGVGGSLRAQVERLRV--ELQRE 585
++ G L+A E+L V LQR+
Sbjct: 2695 RSSIAGLLLKATNEKLSVYAALQRQ 2719
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/322 (22%), Positives = 134/322 (41%), Gaps = 26/322 (8%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQRER--EALREDCAAQAQRAQRAQQLLQLQVFQ 396
E Q + +L E EAT + R + ++ +ALR++ AQ + LQ + +
Sbjct: 1114 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG----AQEVGERLQQRHGE 1169
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQ 456
E + ++ AQLL+ + + + +RE +LG +L + + + + Q
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR----ESADPLGAWLQD 1225
Query: 457 LKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQ-ELQ 514
+ Q ++ ++ A+R LR+ +A L E ++E R + + A ELQ
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQ 1285
Query: 515 RHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQ 574
+A QL+ A+ ++P V + ++
Sbjct: 1286 LVTYKA--------QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
E LR ++ E R E+QR + E ERL AE E + Q+QL + Q + + +E
Sbjct: 1338 SETLR-RMEEEERLAEQQR-AEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKE 1392
Query: 635 LQQ-LSLELEARELADLGLAEQ 655
LQQ + E+ RE A + +Q
Sbjct: 1393 LQQRMQEEVVRREEAAVDAQQQ 1414
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 28/328 (8%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL--REDCAAQAQRAQRAQQL 389
+L + EA L++ R + + QA E + QR +E + RE+ A AQ+ +R+ Q
Sbjct: 1365 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1424
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+LQQ ++ + + ++ E ER +E E R + +LE T+ + GE
Sbjct: 1425 ------ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1478
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE----GRARGLQEAARARELE 505
+ L+ + +E++A+ Q E LR +++ R +E R + EAAR ++
Sbjct: 1479 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1538
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQRA 563
L+A L+ R +AE+ + Q + E A R+ V TA AE S A
Sbjct: 1539 LQA----LEELRLQAEEAERRLRQAEVERA--RQVQVALETAQRSAEAELQSKRASFAEK 1592
Query: 564 AAGVGGSLRAQ---VERLRVELQR---ERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL 617
A + SL+ + V +LR E +R ++ E R+ E E WQ + + +R +L
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RL 1650
Query: 618 QHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q + + Q E E Q+ E EAR
Sbjct: 1651 QAEEVAQQKSLAQAEAEKQKEEAEREAR 1678
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/336 (29%), Positives = 151/336 (44%), Gaps = 41/336 (12%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMC--QAYEERQRHW--QREREALREDCAAQAQRAQR 385
E + EAE + R L NEA QA E Q+ Q E E +E+ +A+R +
Sbjct: 1623 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1682
Query: 386 AQQLLQLQVFQLQQE---KRQLQDDFAQ--LLQEREQLERRCATLEREQRELGPRLEETK 440
A++ Q +QE +RQL + AQ L E+E + R T + EQ+ LEE
Sbjct: 1683 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR--QLLEE-- 1738
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV----ALREARATLRVSEGRARGLQ 496
E+ + E + Q+ +E +AEL + +E+ L A E+R+T S+ R
Sbjct: 1739 -ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-- 1795
Query: 497 EAARAREL-----ELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
EA R REL L A ++E +R RQ AE E A + AEA + + L
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAE---EDAARQRAEAERVLAEKLAAIGEATRL 1852
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG---ERLA-WQAEK 607
E++ A ++ A ++ RL + +RRR EEQ + ERLA +
Sbjct: 1853 KTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1906
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
+ + QK L + + R+ RQ+E+E+ L E
Sbjct: 1907 DSELERQKGLVEDTL---RQRRQVEEEILALKASFE 1939
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 42/342 (12%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
++ L E +Q + +L+E E + E R+ + E+E+ R+ AQ +R Q
Sbjct: 1994 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2053
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ F +QQ++++LQ Q +QL R E + + E Q
Sbjct: 2054 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2113
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ ++LK+S E Q ++ A LR + +E A +A +A + +A
Sbjct: 2114 QVE-EAERLKQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQA 2166
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
E+++H++ AEQ + Q++ E LR L E+D K
Sbjct: 2167 ADAEMEKHKKFAEQTLRQKAQVEQELTTLR-----------LQLEETDHQK--------- 2206
Query: 569 GSLRAQVERLR---VELQRERRRGEE-------QRDSFEGERLAWQAEKEQVIRYQKQLQ 618
L +++RL+ E R+R + EE Q + + +AE +I K
Sbjct: 2207 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2266
Query: 619 HNYIQ-MYRRNRQLEQELQQLSLELE----ARELADLGLAEQ 655
++Q + +Q+ +E +LS+ + R+LA+ LA+Q
Sbjct: 2267 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2308
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/377 (23%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 333 LRDREAELQQLRDSLD------ENEATMCQAYEERQRHWQRERE------ALREDCAAQA 380
LRD++ + L++ + E A + A +E R Q E AL E +
Sbjct: 2260 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2319
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA--------TLERE---Q 429
+A + L+ + LQQ+K Q+ +L +++EQ+ ++ A TLE E Q
Sbjct: 2320 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2379
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATL---- 485
E+ E K V + S + ++ + + + + G +L +A +E + TL
Sbjct: 2380 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTL 2438
Query: 486 ----RVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREP 540
+ S+ A L+EA E E E QE + + ++E+++ + QL E L++
Sbjct: 2439 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2498
Query: 541 PVPPATADPFL----LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-- 594
+ + D L E ++AK+++ + A+ ++LR E QR++++ E++R
Sbjct: 2499 FL--SEKDSLLQRERFIEQEKAKLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRL 2552
Query: 595 --SFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
S E R +E V R Q++LQ Q ++ L +E Q+L +L+ E
Sbjct: 2553 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-----E 2607
Query: 653 AEQAPCICLEEITATEI 669
+A EE+TA+++
Sbjct: 2608 QHRAALAHSEEVTASQV 2624
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 49/350 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
L+++EAE ++LR L E+EA + EE+ + + E +R QL +
Sbjct: 1860 LKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIE-------------ERLAQLRKA 1905
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEV--CQKSGEI 450
+L+++K ++D L++R Q+E L+ + E + E+ + + E
Sbjct: 1906 SDSELERQKGLVEDT----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE--- 507
+L ++ QAEL +A R A RV + A +EAAR R+ LE
Sbjct: 1962 TLRSKE----QAELEAARQRQLAAEEERRRREAEERVQKSLAAE-EEAARQRKAALEEVE 2016
Query: 508 ---ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAA 564
A +E +R R+ AEQ + QL EAA R A A E + + +
Sbjct: 2017 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2076
Query: 565 AGVGGSLRAQVERLR--------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ 616
V LR + E R +Q ER + +R E ERL AE++ R Q Q
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2136
Query: 617 -----LQHNYIQMYRRNRQLEQ----ELQQLSLELEA-RELADLGLAEQA 656
L+ Q R Q EQ + Q E+E ++ A+ L ++A
Sbjct: 2137 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2186
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/351 (24%), Positives = 157/351 (44%), Gaps = 29/351 (8%)
Query: 336 REAELQQL-------RDSLDENEATMCQAYEERQR-------HWQREREALREDCAAQAQ 381
R+ EL+QL R+S D A + A +++ Q RE LR++ A +
Sbjct: 1202 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1261
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKW 441
+ +++ + Q F +Q ++D QL+ + QLE + ++ + + G ++
Sbjct: 1262 IERHGEKVEECQRFA-KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1320
Query: 442 -EVCQKSGEISLLKQQLKESQAELVQKGSELVAL----RVALREARATLRVSEGRARGLQ 496
++ E++ L Q + +E +++ E L R RE A + + + R L
Sbjct: 1321 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1380
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
EA + + E ++ELQ+ QE E +R + +DA+ ++ + +E++
Sbjct: 1381 EAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAE 1436
Query: 557 -EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK 615
+AK ++A A LR + E V LQ E E QR EGE A +A E+ ++
Sbjct: 1437 IQAKARQAEAAERSRLRIEEEIRVVRLQLEAT--ERQRGGAEGELQALRARAEEAEAQKR 1494
Query: 616 QLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLA--EQAPCICLEEI 664
Q Q ++ R+ + Q +Q +EL +R A+ A +Q LEE+
Sbjct: 1495 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1545
Score = 50.4 bits (119), Expect = 5e-06
Identities = 77/337 (22%), Positives = 147/337 (43%), Gaps = 27/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +R RE Q+L E T Q+ E+E +R A+ ++ ++ +QL
Sbjct: 1685 EQAVRQRELAEQELEKQRQLAEGTA-------QQRLAAEQELIR--LRAETEQGEQQRQL 1735
Query: 390 LQLQVFQLQQEK----RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
L+ ++ +LQ+E ++ Q+ A+L + R ++E A+ R + E E++K +
Sbjct: 1736 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1795
Query: 446 KSGEISLLKQQLKESQAELVQ-KGSELVALRVALREARATLRVSEGRARGLQEAARAR-- 502
++G L ++ +A + K +A A R+ RV + + EA R +
Sbjct: 1796 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1855
Query: 503 -ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E+ L+ E +R R+ AE + +L+ +AA + + A L ++ +++++
Sbjct: 1856 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA-QHKADIEERLAQ---LRKASDSELE 1911
Query: 562 RAAAGVGGSL--RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
R V +L R QVE + L+ + + E E ++ E +R ++Q +
Sbjct: 1912 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1971
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQA 656
R RQL E ++ E E R L E+A
Sbjct: 1972 E----AARQRQLAAEEERRRREAEERVQKSLAAEEEA 2004
Score = 44.3 bits (103), Expect = 4e-04
Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 26/265 (9%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALREDCAAQAQR 382
+L+ E + Q L E +A E+ QRER E L +D A+AQ+
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2533
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+ QQ Q Q ++QE+++L + + + + E + E ++L + + +
Sbjct: 2534 LREEQQRQQQQ---MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2590
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ + Q L+E + E+ A +VA AT + GR AA
Sbjct: 2591 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA-----ATKTLPNGRDALDGPAA--- 2642
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E E L+R + A++L+E AG L AE L+ T D E +Q
Sbjct: 2643 EAEPEHSFDGLRR-KVSAQRLQE-AGILSAEE--LQRLAQGHTTVDELARREDVRHYLQG 2698
Query: 563 AAAGVGGSLRAQVERLRV--ELQRE 585
++ G L+A E+L V LQR+
Sbjct: 2699 RSSIAGLLLKATNEKLSVYAALQRQ 2723
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/322 (22%), Positives = 134/322 (41%), Gaps = 26/322 (8%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQRER--EALREDCAAQAQRAQRAQQLLQLQVFQ 396
E Q + +L E EAT + R + ++ +ALR++ AQ + LQ + +
Sbjct: 1118 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG----AQEVGERLQQRHGE 1173
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQ 456
E + ++ AQLL+ + + + +RE +LG +L + + + + Q
Sbjct: 1174 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR----ESADPLGAWLQD 1229
Query: 457 LKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQ-ELQ 514
+ Q ++ ++ A+R LR+ +A L E ++E R + + A ELQ
Sbjct: 1230 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQ 1289
Query: 515 RHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQ 574
+A QL+ A+ ++P V + ++
Sbjct: 1290 LVTYKA--------QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1341
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
E LR ++ E R E+QR + E ERL AE E + Q+QL + Q + + +E
Sbjct: 1342 SETLR-RMEEEERLAEQQR-AEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKE 1396
Query: 635 LQQ-LSLELEARELADLGLAEQ 655
LQQ + E+ RE A + +Q
Sbjct: 1397 LQQRMQEEVVRREEAAVDAQQQ 1418
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 28/328 (8%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL--REDCAAQAQRAQRAQQL 389
+L + EA L++ R + + QA E + QR +E + RE+ A AQ+ +R+ Q
Sbjct: 1361 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1420
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+LQQ ++ + + ++ E ER +E E R + +LE T+ + GE
Sbjct: 1421 ------ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1474
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE----GRARGLQEAARARELE 505
+ L+ + +E++A+ Q E LR +++ R +E R + EAAR ++
Sbjct: 1475 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1534
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQRA 563
L+A L+ R +AE+ + Q + E A R+ V TA AE S A
Sbjct: 1535 LQA----LEELRLQAEEAERRLRQAEVERA--RQVQVALETAQRSAEAELQSKRASFAEK 1588
Query: 564 AAGVGGSLRAQ---VERLRVELQR---ERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL 617
A + SL+ + V +LR E +R ++ E R+ E E WQ + + +R +L
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RL 1646
Query: 618 QHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q + + Q E E Q+ E EAR
Sbjct: 1647 QAEEVAQQKSLAQAEAEKQKEEAEREAR 1674
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/336 (29%), Positives = 151/336 (44%), Gaps = 41/336 (12%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMC--QAYEERQRHW--QREREALREDCAAQAQRAQR 385
E + EAE + R L NEA QA E Q+ Q E E +E+ +A+R +
Sbjct: 1619 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1678
Query: 386 AQQLLQLQVFQLQQE---KRQLQDDFAQ--LLQEREQLERRCATLEREQRELGPRLEETK 440
A++ Q +QE +RQL + AQ L E+E + R T + EQ+ LEE
Sbjct: 1679 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR--QLLEE-- 1734
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV----ALREARATLRVSEGRARGLQ 496
E+ + E + Q+ +E +AEL + +E+ L A E+R+T S+ R
Sbjct: 1735 -ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-- 1791
Query: 497 EAARAREL-----ELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
EA R REL L A ++E +R RQ AE E A + AEA + + L
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAE---EDAARQRAEAERVLAEKLAAIGEATRL 1848
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG---ERLA-WQAEK 607
E++ A ++ A ++ RL + +RRR EEQ + ERLA +
Sbjct: 1849 KTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1902
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
+ + QK L + + R+ RQ+E+E+ L E
Sbjct: 1903 DSELERQKGLVEDTL---RQRRQVEEEILALKASFE 1935
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 42/342 (12%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
++ L E +Q + +L+E E + E R+ + E+E+ R+ AQ +R Q
Sbjct: 1990 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2049
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ F +QQ++++LQ Q +QL R E + + E Q
Sbjct: 2050 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2109
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ ++LK+S E Q ++ A LR + +E A +A +A + +A
Sbjct: 2110 QVE-EAERLKQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQA 2162
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
E+++H++ AEQ + Q++ E LR L E+D K
Sbjct: 2163 ADAEMEKHKKFAEQTLRQKAQVEQELTTLR-----------LQLEETDHQK--------- 2202
Query: 569 GSLRAQVERLR---VELQRERRRGEE-------QRDSFEGERLAWQAEKEQVIRYQKQLQ 618
L +++RL+ E R+R + EE Q + + +AE +I K
Sbjct: 2203 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2262
Query: 619 HNYIQ-MYRRNRQLEQELQQLSLELE----ARELADLGLAEQ 655
++Q + +Q+ +E +LS+ + R+LA+ LA+Q
Sbjct: 2263 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2304
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/377 (23%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 333 LRDREAELQQLRDSLD------ENEATMCQAYEERQRHWQRERE------ALREDCAAQA 380
LRD++ + L++ + E A + A +E R Q E AL E +
Sbjct: 2256 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2315
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA--------TLERE---Q 429
+A + L+ + LQQ+K Q+ +L +++EQ+ ++ A TLE E Q
Sbjct: 2316 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2375
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATL---- 485
E+ E K V + S + ++ + + + + G +L +A +E + TL
Sbjct: 2376 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTL 2434
Query: 486 ----RVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREP 540
+ S+ A L+EA E E E QE + + ++E+++ + QL E L++
Sbjct: 2435 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2494
Query: 541 PVPPATADPFL----LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-- 594
+ + D L E ++AK+++ + A+ ++LR E QR++++ E++R
Sbjct: 2495 FL--SEKDSLLQRERFIEQEKAKLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRL 2548
Query: 595 --SFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
S E R +E V R Q++LQ Q ++ L +E Q+L +L+ E
Sbjct: 2549 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-----E 2603
Query: 653 AEQAPCICLEEITATEI 669
+A EE+TA+++
Sbjct: 2604 QHRAALAHSEEVTASQV 2620
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 49/350 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
L+++EAE ++LR L E+EA + EE+ + + E +R QL +
Sbjct: 1856 LKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIE-------------ERLAQLRKA 1901
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEV--CQKSGEI 450
+L+++K ++D L++R Q+E L+ + E + E+ + + E
Sbjct: 1902 SDSELERQKGLVEDT----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE--- 507
+L ++ QAEL +A R A RV + A +EAAR R+ LE
Sbjct: 1958 TLRSKE----QAELEAARQRQLAAEEERRRREAEERVQKSLAAE-EEAARQRKAALEEVE 2012
Query: 508 ---ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAA 564
A +E +R R+ AEQ + QL EAA R A A E + + +
Sbjct: 2013 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2072
Query: 565 AGVGGSLRAQVERLR--------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ 616
V LR + E R +Q ER + +R E ERL AE++ R Q Q
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2132
Query: 617 -----LQHNYIQMYRRNRQLEQ----ELQQLSLELEA-RELADLGLAEQA 656
L+ Q R Q EQ + Q E+E ++ A+ L ++A
Sbjct: 2133 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2182
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/351 (24%), Positives = 157/351 (44%), Gaps = 29/351 (8%)
Query: 336 REAELQQL-------RDSLDENEATMCQAYEERQR-------HWQREREALREDCAAQAQ 381
R+ EL+QL R+S D A + A +++ Q RE LR++ A +
Sbjct: 1198 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1257
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKW 441
+ +++ + Q F +Q ++D QL+ + QLE + ++ + + G ++
Sbjct: 1258 IERHGEKVEECQRFA-KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1316
Query: 442 -EVCQKSGEISLLKQQLKESQAELVQKGSELVAL----RVALREARATLRVSEGRARGLQ 496
++ E++ L Q + +E +++ E L R RE A + + + R L
Sbjct: 1317 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1376
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
EA + + E ++ELQ+ QE E +R + +DA+ ++ + +E++
Sbjct: 1377 EAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAE 1432
Query: 557 -EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK 615
+AK ++A A LR + E V LQ E E QR EGE A +A E+ ++
Sbjct: 1433 IQAKARQAEAAERSRLRIEEEIRVVRLQLEAT--ERQRGGAEGELQALRARAEEAEAQKR 1490
Query: 616 QLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLA--EQAPCICLEEI 664
Q Q ++ R+ + Q +Q +EL +R A+ A +Q LEE+
Sbjct: 1491 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1541
Score = 50.4 bits (119), Expect = 5e-06
Identities = 77/337 (22%), Positives = 147/337 (43%), Gaps = 27/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +R RE Q+L E T Q+ E+E +R A+ ++ ++ +QL
Sbjct: 1681 EQAVRQRELAEQELEKQRQLAEGTA-------QQRLAAEQELIR--LRAETEQGEQQRQL 1731
Query: 390 LQLQVFQLQQEK----RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
L+ ++ +LQ+E ++ Q+ A+L + R ++E A+ R + E E++K +
Sbjct: 1732 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1791
Query: 446 KSGEISLLKQQLKESQAELVQ-KGSELVALRVALREARATLRVSEGRARGLQEAARAR-- 502
++G L ++ +A + K +A A R+ RV + + EA R +
Sbjct: 1792 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1851
Query: 503 -ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E+ L+ E +R R+ AE + +L+ +AA + + A L ++ +++++
Sbjct: 1852 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA-QHKADIEERLAQ---LRKASDSELE 1907
Query: 562 RAAAGVGGSL--RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
R V +L R QVE + L+ + + E E ++ E +R ++Q +
Sbjct: 1908 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1967
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQA 656
R RQL E ++ E E R L E+A
Sbjct: 1968 E----AARQRQLAAEEERRRREAEERVQKSLAAEEEA 2000
Score = 44.3 bits (103), Expect = 4e-04
Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 26/265 (9%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALREDCAAQAQR 382
+L+ E + Q L E +A E+ QRER E L +D A+AQ+
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2529
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+ QQ Q Q ++QE+++L + + + + E + E ++L + + +
Sbjct: 2530 LREEQQRQQQQ---MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2586
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ + Q L+E + E+ A +VA AT + GR AA
Sbjct: 2587 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA-----ATKTLPNGRDALDGPAA--- 2638
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E E L+R + A++L+E AG L AE L+ T D E +Q
Sbjct: 2639 EAEPEHSFDGLRR-KVSAQRLQE-AGILSAEE--LQRLAQGHTTVDELARREDVRHYLQG 2694
Query: 563 AAAGVGGSLRAQVERLRV--ELQRE 585
++ G L+A E+L V LQR+
Sbjct: 2695 RSSIAGLLLKATNEKLSVYAALQRQ 2719
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/322 (22%), Positives = 134/322 (41%), Gaps = 26/322 (8%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQRER--EALREDCAAQAQRAQRAQQLLQLQVFQ 396
E Q + +L E EAT + R + ++ +ALR++ AQ + LQ + +
Sbjct: 1114 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG----AQEVGERLQQRHGE 1169
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQ 456
E + ++ AQLL+ + + + +RE +LG +L + + + + Q
Sbjct: 1170 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR----ESADPLGAWLQD 1225
Query: 457 LKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQ-ELQ 514
+ Q ++ ++ A+R LR+ +A L E ++E R + + A ELQ
Sbjct: 1226 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQ 1285
Query: 515 RHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQ 574
+A QL+ A+ ++P V + ++
Sbjct: 1286 LVTYKA--------QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1337
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
E LR ++ E R E+QR + E ERL AE E + Q+QL + Q + + +E
Sbjct: 1338 SETLR-RMEEEERLAEQQR-AEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKE 1392
Query: 635 LQQ-LSLELEARELADLGLAEQ 655
LQQ + E+ RE A + +Q
Sbjct: 1393 LQQRMQEEVVRREEAAVDAQQQ 1414
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 28/328 (8%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL--REDCAAQAQRAQRAQQL 389
+L + EA L++ R + + QA E + QR +E + RE+ A AQ+ +R+ Q
Sbjct: 1329 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1388
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+LQQ ++ + + ++ E ER +E E R + +LE T+ + GE
Sbjct: 1389 ------ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1442
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE----GRARGLQEAARARELE 505
+ L+ + +E++A+ Q E LR +++ R +E R + EAAR ++
Sbjct: 1443 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1502
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQRA 563
L+A L+ R +AE+ + Q + E A R+ V TA AE S A
Sbjct: 1503 LQA----LEELRLQAEEAERRLRQAEVERA--RQVQVALETAQRSAEAELQSKRASFAEK 1556
Query: 564 AAGVGGSLRAQ---VERLRVELQR---ERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL 617
A + SL+ + V +LR E +R ++ E R+ E E WQ + + +R +L
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RL 1614
Query: 618 QHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q + + Q E E Q+ E EAR
Sbjct: 1615 QAEEVAQQKSLAQAEAEKQKEEAEREAR 1642
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/336 (29%), Positives = 151/336 (44%), Gaps = 41/336 (12%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMC--QAYEERQRHW--QREREALREDCAAQAQRAQR 385
E + EAE + R L NEA QA E Q+ Q E E +E+ +A+R +
Sbjct: 1587 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1646
Query: 386 AQQLLQLQVFQLQQE---KRQLQDDFAQ--LLQEREQLERRCATLEREQRELGPRLEETK 440
A++ Q +QE +RQL + AQ L E+E + R T + EQ+ LEE
Sbjct: 1647 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR--QLLEE-- 1702
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV----ALREARATLRVSEGRARGLQ 496
E+ + E + Q+ +E +AEL + +E+ L A E+R+T S+ R
Sbjct: 1703 -ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-- 1759
Query: 497 EAARAREL-----ELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
EA R REL L A ++E +R RQ AE E A + AEA + + L
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAE---EDAARQRAEAERVLAEKLAAIGEATRL 1816
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG---ERLA-WQAEK 607
E++ A ++ A ++ RL + +RRR EEQ + ERLA +
Sbjct: 1817 KTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1870
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
+ + QK L + + R+ RQ+E+E+ L E
Sbjct: 1871 DSELERQKGLVEDTL---RQRRQVEEEILALKASFE 1903
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 42/342 (12%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
++ L E +Q + +L+E E + E R+ + E+E+ R+ AQ +R Q
Sbjct: 1958 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2017
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ F +QQ++++LQ Q +QL R E + + E Q
Sbjct: 2018 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2077
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ ++LK+S E Q ++ A LR + +E A +A +A + +A
Sbjct: 2078 QVE-EAERLKQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQA 2130
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
E+++H++ AEQ + Q++ E LR L E+D K
Sbjct: 2131 ADAEMEKHKKFAEQTLRQKAQVEQELTTLR-----------LQLEETDHQK--------- 2170
Query: 569 GSLRAQVERLR---VELQRERRRGEE-------QRDSFEGERLAWQAEKEQVIRYQKQLQ 618
L +++RL+ E R+R + EE Q + + +AE +I K
Sbjct: 2171 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2230
Query: 619 HNYIQ-MYRRNRQLEQELQQLSLELE----ARELADLGLAEQ 655
++Q + +Q+ +E +LS+ + R+LA+ LA+Q
Sbjct: 2231 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2272
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/377 (23%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 333 LRDREAELQQLRDSLD------ENEATMCQAYEERQRHWQRERE------ALREDCAAQA 380
LRD++ + L++ + E A + A +E R Q E AL E +
Sbjct: 2224 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2283
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA--------TLERE---Q 429
+A + L+ + LQQ+K Q+ +L +++EQ+ ++ A TLE E Q
Sbjct: 2284 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2343
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATL---- 485
E+ E K V + S + ++ + + + + G +L +A +E + TL
Sbjct: 2344 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTL 2402
Query: 486 ----RVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREP 540
+ S+ A L+EA E E E QE + + ++E+++ + QL E L++
Sbjct: 2403 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2462
Query: 541 PVPPATADPFL----LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-- 594
+ + D L E ++AK+++ + A+ ++LR E QR++++ E++R
Sbjct: 2463 FL--SEKDSLLQRERFIEQEKAKLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRL 2516
Query: 595 --SFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
S E R +E V R Q++LQ Q ++ L +E Q+L +L+ E
Sbjct: 2517 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-----E 2571
Query: 653 AEQAPCICLEEITATEI 669
+A EE+TA+++
Sbjct: 2572 QHRAALAHSEEVTASQV 2588
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 49/350 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
L+++EAE ++LR L E+EA + EE+ + + E +R QL +
Sbjct: 1824 LKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIE-------------ERLAQLRKA 1869
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEV--CQKSGEI 450
+L+++K ++D L++R Q+E L+ + E + E+ + + E
Sbjct: 1870 SDSELERQKGLVEDT----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE--- 507
+L ++ QAEL +A R A RV + A +EAAR R+ LE
Sbjct: 1926 TLRSKE----QAELEAARQRQLAAEEERRRREAEERVQKSLAAE-EEAARQRKAALEEVE 1980
Query: 508 ---ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAA 564
A +E +R R+ AEQ + QL EAA R A A E + + +
Sbjct: 1981 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2040
Query: 565 AGVGGSLRAQVERLR--------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ 616
V LR + E R +Q ER + +R E ERL AE++ R Q Q
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2100
Query: 617 -----LQHNYIQMYRRNRQLEQ----ELQQLSLELEA-RELADLGLAEQA 656
L+ Q R Q EQ + Q E+E ++ A+ L ++A
Sbjct: 2101 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2150
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/351 (24%), Positives = 157/351 (44%), Gaps = 29/351 (8%)
Query: 336 REAELQQL-------RDSLDENEATMCQAYEERQR-------HWQREREALREDCAAQAQ 381
R+ EL+QL R+S D A + A +++ Q RE LR++ A +
Sbjct: 1166 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1225
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKW 441
+ +++ + Q F +Q ++D QL+ + QLE + ++ + + G ++
Sbjct: 1226 IERHGEKVEECQRFA-KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1284
Query: 442 -EVCQKSGEISLLKQQLKESQAELVQKGSELVAL----RVALREARATLRVSEGRARGLQ 496
++ E++ L Q + +E +++ E L R RE A + + + R L
Sbjct: 1285 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1344
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
EA + + E ++ELQ+ QE E +R + +DA+ ++ + +E++
Sbjct: 1345 EAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAE 1400
Query: 557 -EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK 615
+AK ++A A LR + E V LQ E E QR EGE A +A E+ ++
Sbjct: 1401 IQAKARQAEAAERSRLRIEEEIRVVRLQLEAT--ERQRGGAEGELQALRARAEEAEAQKR 1458
Query: 616 QLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLA--EQAPCICLEEI 664
Q Q ++ R+ + Q +Q +EL +R A+ A +Q LEE+
Sbjct: 1459 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1509
Score = 50.4 bits (119), Expect = 5e-06
Identities = 77/337 (22%), Positives = 147/337 (43%), Gaps = 27/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +R RE Q+L E T Q+ E+E +R A+ ++ ++ +QL
Sbjct: 1649 EQAVRQRELAEQELEKQRQLAEGTA-------QQRLAAEQELIR--LRAETEQGEQQRQL 1699
Query: 390 LQLQVFQLQQEK----RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
L+ ++ +LQ+E ++ Q+ A+L + R ++E A+ R + E E++K +
Sbjct: 1700 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1759
Query: 446 KSGEISLLKQQLKESQAELVQ-KGSELVALRVALREARATLRVSEGRARGLQEAARAR-- 502
++G L ++ +A + K +A A R+ RV + + EA R +
Sbjct: 1760 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1819
Query: 503 -ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E+ L+ E +R R+ AE + +L+ +AA + + A L ++ +++++
Sbjct: 1820 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA-QHKADIEERLAQ---LRKASDSELE 1875
Query: 562 RAAAGVGGSL--RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
R V +L R QVE + L+ + + E E ++ E +R ++Q +
Sbjct: 1876 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1935
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQA 656
R RQL E ++ E E R L E+A
Sbjct: 1936 E----AARQRQLAAEEERRRREAEERVQKSLAAEEEA 1968
Score = 44.3 bits (103), Expect = 4e-04
Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 26/265 (9%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALREDCAAQAQR 382
+L+ E + Q L E +A E+ QRER E L +D A+AQ+
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2497
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+ QQ Q Q ++QE+++L + + + + E + E ++L + + +
Sbjct: 2498 LREEQQRQQQQ---MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2554
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ + Q L+E + E+ A +VA AT + GR AA
Sbjct: 2555 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA-----ATKTLPNGRDALDGPAA--- 2606
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E E L+R + A++L+E AG L AE L+ T D E +Q
Sbjct: 2607 EAEPEHSFDGLRR-KVSAQRLQE-AGILSAEE--LQRLAQGHTTVDELARREDVRHYLQG 2662
Query: 563 AAAGVGGSLRAQVERLRV--ELQRE 585
++ G L+A E+L V LQR+
Sbjct: 2663 RSSIAGLLLKATNEKLSVYAALQRQ 2687
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/322 (22%), Positives = 134/322 (41%), Gaps = 26/322 (8%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQRER--EALREDCAAQAQRAQRAQQLLQLQVFQ 396
E Q + +L E EAT + R + ++ +ALR++ AQ + LQ + +
Sbjct: 1082 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG----AQEVGERLQQRHGE 1137
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQ 456
E + ++ AQLL+ + + + +RE +LG +L + + + + Q
Sbjct: 1138 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR----ESADPLGAWLQD 1193
Query: 457 LKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQ-ELQ 514
+ Q ++ ++ A+R LR+ +A L E ++E R + + A ELQ
Sbjct: 1194 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQ 1253
Query: 515 RHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQ 574
+A QL+ A+ ++P V + ++
Sbjct: 1254 LVTYKA--------QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1305
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
E LR ++ E R E+QR + E ERL AE E + Q+QL + Q + + +E
Sbjct: 1306 SETLR-RMEEEERLAEQQR-AEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKE 1360
Query: 635 LQQ-LSLELEARELADLGLAEQ 655
LQQ + E+ RE A + +Q
Sbjct: 1361 LQQRMQEEVVRREEAAVDAQQQ 1382
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 28/328 (8%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL--REDCAAQAQRAQRAQQL 389
+L + EA L++ R + + QA E + QR +E + RE+ A AQ+ +R+ Q
Sbjct: 1498 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1557
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+LQQ ++ + + ++ E ER +E E R + +LE T+ + GE
Sbjct: 1558 ------ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE----GRARGLQEAARARELE 505
+ L+ + +E++A+ Q E LR +++ R +E R + EAAR ++
Sbjct: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1671
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQRA 563
L+A L+ R +AE+ + Q + E A R+ V TA AE S A
Sbjct: 1672 LQA----LEELRLQAEEAERRLRQAEVERA--RQVQVALETAQRSAEAELQSKRASFAEK 1725
Query: 564 AAGVGGSLRAQ---VERLRVELQR---ERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL 617
A + SL+ + V +LR E +R ++ E R+ E E WQ + + +R +L
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RL 1783
Query: 618 QHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q + + Q E E Q+ E EAR
Sbjct: 1784 QAEEVAQQKSLAQAEAEKQKEEAEREAR 1811
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/336 (29%), Positives = 151/336 (44%), Gaps = 41/336 (12%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMC--QAYEERQRHW--QREREALREDCAAQAQRAQR 385
E + EAE + R L NEA QA E Q+ Q E E +E+ +A+R +
Sbjct: 1756 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1815
Query: 386 AQQLLQLQVFQLQQE---KRQLQDDFAQ--LLQEREQLERRCATLEREQRELGPRLEETK 440
A++ Q +QE +RQL + AQ L E+E + R T + EQ+ LEE
Sbjct: 1816 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR--QLLEE-- 1871
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV----ALREARATLRVSEGRARGLQ 496
E+ + E + Q+ +E +AEL + +E+ L A E+R+T S+ R
Sbjct: 1872 -ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-- 1928
Query: 497 EAARAREL-----ELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
EA R REL L A ++E +R RQ AE E A + AEA + + L
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAE---EDAARQRAEAERVLAEKLAAIGEATRL 1985
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG---ERLA-WQAEK 607
E++ A ++ A ++ RL + +RRR EEQ + ERLA +
Sbjct: 1986 KTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 2039
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
+ + QK L + + R+ RQ+E+E+ L E
Sbjct: 2040 DSELERQKGLVEDTL---RQRRQVEEEILALKASFE 2072
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 42/342 (12%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
++ L E +Q + +L+E E + E R+ + E+E+ R+ AQ +R Q
Sbjct: 2127 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2186
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ F +QQ++++LQ Q +QL R E + + E Q
Sbjct: 2187 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2246
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ ++LK+S E Q ++ A LR + +E A +A +A + +A
Sbjct: 2247 QVE-EAERLKQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQA 2299
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
E+++H++ AEQ + Q++ E LR L E+D K
Sbjct: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLR-----------LQLEETDHQK--------- 2339
Query: 569 GSLRAQVERLR---VELQRERRRGEE-------QRDSFEGERLAWQAEKEQVIRYQKQLQ 618
L +++RL+ E R+R + EE Q + + +AE +I K
Sbjct: 2340 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2399
Query: 619 HNYIQ-MYRRNRQLEQELQQLSLELE----ARELADLGLAEQ 655
++Q + +Q+ +E +LS+ + R+LA+ LA+Q
Sbjct: 2400 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/377 (23%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 333 LRDREAELQQLRDSLD------ENEATMCQAYEERQRHWQRERE------ALREDCAAQA 380
LRD++ + L++ + E A + A +E R Q E AL E +
Sbjct: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2452
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA--------TLERE---Q 429
+A + L+ + LQQ+K Q+ +L +++EQ+ ++ A TLE E Q
Sbjct: 2453 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2512
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATL---- 485
E+ E K V + S + ++ + + + + G +L +A +E + TL
Sbjct: 2513 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTL 2571
Query: 486 ----RVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREP 540
+ S+ A L+EA E E E QE + + ++E+++ + QL E L++
Sbjct: 2572 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631
Query: 541 PVPPATADPFL----LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-- 594
+ + D L E ++AK+++ + A+ ++LR E QR++++ E++R
Sbjct: 2632 FL--SEKDSLLQRERFIEQEKAKLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685
Query: 595 --SFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
S E R +E V R Q++LQ Q ++ L +E Q+L +L+ E
Sbjct: 2686 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-----E 2740
Query: 653 AEQAPCICLEEITATEI 669
+A EE+TA+++
Sbjct: 2741 QHRAALAHSEEVTASQV 2757
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 49/350 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
L+++EAE ++LR L E+EA + EE+ + + E +R QL +
Sbjct: 1993 LKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIE-------------ERLAQLRKA 2038
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEV--CQKSGEI 450
+L+++K ++D L++R Q+E L+ + E + E+ + + E
Sbjct: 2039 SDSELERQKGLVEDT----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE--- 507
+L ++ QAEL +A R A RV + A +EAAR R+ LE
Sbjct: 2095 TLRSKE----QAELEAARQRQLAAEEERRRREAEERVQKSLAAE-EEAARQRKAALEEVE 2149
Query: 508 ---ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAA 564
A +E +R R+ AEQ + QL EAA R A A E + + +
Sbjct: 2150 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2209
Query: 565 AGVGGSLRAQVERLR--------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ 616
V LR + E R +Q ER + +R E ERL AE++ R Q Q
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2269
Query: 617 -----LQHNYIQMYRRNRQLEQ----ELQQLSLELEA-RELADLGLAEQA 656
L+ Q R Q EQ + Q E+E ++ A+ L ++A
Sbjct: 2270 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2319
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/351 (24%), Positives = 157/351 (44%), Gaps = 29/351 (8%)
Query: 336 REAELQQL-------RDSLDENEATMCQAYEERQR-------HWQREREALREDCAAQAQ 381
R+ EL+QL R+S D A + A +++ Q RE LR++ A +
Sbjct: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKW 441
+ +++ + Q F +Q ++D QL+ + QLE + ++ + + G ++
Sbjct: 1395 IERHGEKVEECQRFA-KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1453
Query: 442 -EVCQKSGEISLLKQQLKESQAELVQKGSELVAL----RVALREARATLRVSEGRARGLQ 496
++ E++ L Q + +E +++ E L R RE A + + + R L
Sbjct: 1454 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1513
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
EA + + E ++ELQ+ QE E +R + +DA+ ++ + +E++
Sbjct: 1514 EAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAE 1569
Query: 557 -EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK 615
+AK ++A A LR + E V LQ E E QR EGE A +A E+ ++
Sbjct: 1570 IQAKARQAEAAERSRLRIEEEIRVVRLQLEAT--ERQRGGAEGELQALRARAEEAEAQKR 1627
Query: 616 QLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLA--EQAPCICLEEI 664
Q Q ++ R+ + Q +Q +EL +R A+ A +Q LEE+
Sbjct: 1628 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1678
Score = 50.4 bits (119), Expect = 5e-06
Identities = 77/337 (22%), Positives = 147/337 (43%), Gaps = 27/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +R RE Q+L E T Q+ E+E +R A+ ++ ++ +QL
Sbjct: 1818 EQAVRQRELAEQELEKQRQLAEGTA-------QQRLAAEQELIR--LRAETEQGEQQRQL 1868
Query: 390 LQLQVFQLQQEK----RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
L+ ++ +LQ+E ++ Q+ A+L + R ++E A+ R + E E++K +
Sbjct: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928
Query: 446 KSGEISLLKQQLKESQAELVQ-KGSELVALRVALREARATLRVSEGRARGLQEAARAR-- 502
++G L ++ +A + K +A A R+ RV + + EA R +
Sbjct: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1988
Query: 503 -ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E+ L+ E +R R+ AE + +L+ +AA + + A L ++ +++++
Sbjct: 1989 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA-QHKADIEERLAQ---LRKASDSELE 2044
Query: 562 RAAAGVGGSL--RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
R V +L R QVE + L+ + + E E ++ E +R ++Q +
Sbjct: 2045 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 2104
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQA 656
R RQL E ++ E E R L E+A
Sbjct: 2105 E----AARQRQLAAEEERRRREAEERVQKSLAAEEEA 2137
Score = 44.3 bits (103), Expect = 4e-04
Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 26/265 (9%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALREDCAAQAQR 382
+L+ E + Q L E +A E+ QRER E L +D A+AQ+
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2666
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+ QQ Q Q ++QE+++L + + + + E + E ++L + + +
Sbjct: 2667 LREEQQRQQQQ---MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2723
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ + Q L+E + E+ A +VA AT + GR AA
Sbjct: 2724 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA-----ATKTLPNGRDALDGPAA--- 2775
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E E L+R + A++L+E AG L AE L+ T D E +Q
Sbjct: 2776 EAEPEHSFDGLRR-KVSAQRLQE-AGILSAEE--LQRLAQGHTTVDELARREDVRHYLQG 2831
Query: 563 AAAGVGGSLRAQVERLRV--ELQRE 585
++ G L+A E+L V LQR+
Sbjct: 2832 RSSIAGLLLKATNEKLSVYAALQRQ 2856
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/322 (22%), Positives = 134/322 (41%), Gaps = 26/322 (8%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQRER--EALREDCAAQAQRAQRAQQLLQLQVFQ 396
E Q + +L E EAT + R + ++ +ALR++ AQ + LQ + +
Sbjct: 1251 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG----AQEVGERLQQRHGE 1306
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQ 456
E + ++ AQLL+ + + + +RE +LG +L + + + + Q
Sbjct: 1307 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR----ESADPLGAWLQD 1362
Query: 457 LKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQ-ELQ 514
+ Q ++ ++ A+R LR+ +A L E ++E R + + A ELQ
Sbjct: 1363 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQ 1422
Query: 515 RHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQ 574
+A QL+ A+ ++P V + ++
Sbjct: 1423 LVTYKA--------QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1474
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
E LR ++ E R E+QR + E ERL AE E + Q+QL + Q + + +E
Sbjct: 1475 SETLR-RMEEEERLAEQQR-AEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKE 1529
Query: 635 LQQ-LSLELEARELADLGLAEQ 655
LQQ + E+ RE A + +Q
Sbjct: 1530 LQQRMQEEVVRREEAAVDAQQQ 1551
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 28/328 (8%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL--REDCAAQAQRAQRAQQL 389
+L + EA L++ R + + QA E + QR +E + RE+ A AQ+ +R+ Q
Sbjct: 1339 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1398
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+LQQ ++ + + ++ E ER +E E R + +LE T+ + GE
Sbjct: 1399 ------ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE----GRARGLQEAARARELE 505
+ L+ + +E++A+ Q E LR +++ R +E R + EAAR ++
Sbjct: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1512
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQRA 563
L+A L+ R +AE+ + Q + E A R+ V TA AE S A
Sbjct: 1513 LQA----LEELRLQAEEAERRLRQAEVERA--RQVQVALETAQRSAEAELQSKRASFAEK 1566
Query: 564 AAGVGGSLRAQ---VERLRVELQR---ERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL 617
A + SL+ + V +LR E +R ++ E R+ E E WQ + + +R +L
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RL 1624
Query: 618 QHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q + + Q E E Q+ E EAR
Sbjct: 1625 QAEEVAQQKSLAQAEAEKQKEEAEREAR 1652
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/336 (29%), Positives = 151/336 (44%), Gaps = 41/336 (12%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMC--QAYEERQRHW--QREREALREDCAAQAQRAQR 385
E + EAE + R L NEA QA E Q+ Q E E +E+ +A+R +
Sbjct: 1597 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1656
Query: 386 AQQLLQLQVFQLQQE---KRQLQDDFAQ--LLQEREQLERRCATLEREQRELGPRLEETK 440
A++ Q +QE +RQL + AQ L E+E + R T + EQ+ LEE
Sbjct: 1657 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR--QLLEE-- 1712
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV----ALREARATLRVSEGRARGLQ 496
E+ + E + Q+ +E +AEL + +E+ L A E+R+T S+ R
Sbjct: 1713 -ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-- 1769
Query: 497 EAARAREL-----ELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
EA R REL L A ++E +R RQ AE E A + AEA + + L
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAE---EDAARQRAEAERVLAEKLAAIGEATRL 1826
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG---ERLA-WQAEK 607
E++ A ++ A ++ RL + +RRR EEQ + ERLA +
Sbjct: 1827 KTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1880
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
+ + QK L + + R+ RQ+E+E+ L E
Sbjct: 1881 DSELERQKGLVEDTL---RQRRQVEEEILALKASFE 1913
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 42/342 (12%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
++ L E +Q + +L+E E + E R+ + E+E+ R+ AQ +R Q
Sbjct: 1968 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2027
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ F +QQ++++LQ Q +QL R E + + E Q
Sbjct: 2028 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2087
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ ++LK+S E Q ++ A LR + +E A +A +A + +A
Sbjct: 2088 QVE-EAERLKQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQA 2140
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
E+++H++ AEQ + Q++ E LR L E+D K
Sbjct: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLR-----------LQLEETDHQK--------- 2180
Query: 569 GSLRAQVERLR---VELQRERRRGEE-------QRDSFEGERLAWQAEKEQVIRYQKQLQ 618
L +++RL+ E R+R + EE Q + + +AE +I K
Sbjct: 2181 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2240
Query: 619 HNYIQ-MYRRNRQLEQELQQLSLELE----ARELADLGLAEQ 655
++Q + +Q+ +E +LS+ + R+LA+ LA+Q
Sbjct: 2241 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/377 (23%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 333 LRDREAELQQLRDSLD------ENEATMCQAYEERQRHWQRERE------ALREDCAAQA 380
LRD++ + L++ + E A + A +E R Q E AL E +
Sbjct: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2293
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA--------TLERE---Q 429
+A + L+ + LQQ+K Q+ +L +++EQ+ ++ A TLE E Q
Sbjct: 2294 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2353
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATL---- 485
E+ E K V + S + ++ + + + + G +L +A +E + TL
Sbjct: 2354 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTL 2412
Query: 486 ----RVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREP 540
+ S+ A L+EA E E E QE + + ++E+++ + QL E L++
Sbjct: 2413 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472
Query: 541 PVPPATADPFL----LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-- 594
+ + D L E ++AK+++ + A+ ++LR E QR++++ E++R
Sbjct: 2473 FL--SEKDSLLQRERFIEQEKAKLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526
Query: 595 --SFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
S E R +E V R Q++LQ Q ++ L +E Q+L +L+ E
Sbjct: 2527 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-----E 2581
Query: 653 AEQAPCICLEEITATEI 669
+A EE+TA+++
Sbjct: 2582 QHRAALAHSEEVTASQV 2598
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 49/350 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
L+++EAE ++LR L E+EA + EE+ + + E +R QL +
Sbjct: 1834 LKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIE-------------ERLAQLRKA 1879
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEV--CQKSGEI 450
+L+++K ++D L++R Q+E L+ + E + E+ + + E
Sbjct: 1880 SDSELERQKGLVEDT----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE--- 507
+L ++ QAEL +A R A RV + A +EAAR R+ LE
Sbjct: 1936 TLRSKE----QAELEAARQRQLAAEEERRRREAEERVQKSLAAE-EEAARQRKAALEEVE 1990
Query: 508 ---ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAA 564
A +E +R R+ AEQ + QL EAA R A A E + + +
Sbjct: 1991 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2050
Query: 565 AGVGGSLRAQVERLR--------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ 616
V LR + E R +Q ER + +R E ERL AE++ R Q Q
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2110
Query: 617 -----LQHNYIQMYRRNRQLEQ----ELQQLSLELEA-RELADLGLAEQA 656
L+ Q R Q EQ + Q E+E ++ A+ L ++A
Sbjct: 2111 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/351 (24%), Positives = 157/351 (44%), Gaps = 29/351 (8%)
Query: 336 REAELQQL-------RDSLDENEATMCQAYEERQR-------HWQREREALREDCAAQAQ 381
R+ EL+QL R+S D A + A +++ Q RE LR++ A +
Sbjct: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKW 441
+ +++ + Q F +Q ++D QL+ + QLE + ++ + + G ++
Sbjct: 1236 IERHGEKVEECQRFA-KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1294
Query: 442 -EVCQKSGEISLLKQQLKESQAELVQKGSELVAL----RVALREARATLRVSEGRARGLQ 496
++ E++ L Q + +E +++ E L R RE A + + + R L
Sbjct: 1295 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1354
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
EA + + E ++ELQ+ QE E +R + +DA+ ++ + +E++
Sbjct: 1355 EAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAE 1410
Query: 557 -EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK 615
+AK ++A A LR + E V LQ E E QR EGE A +A E+ ++
Sbjct: 1411 IQAKARQAEAAERSRLRIEEEIRVVRLQLEAT--ERQRGGAEGELQALRARAEEAEAQKR 1468
Query: 616 QLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLA--EQAPCICLEEI 664
Q Q ++ R+ + Q +Q +EL +R A+ A +Q LEE+
Sbjct: 1469 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1519
Score = 50.4 bits (119), Expect = 5e-06
Identities = 77/337 (22%), Positives = 147/337 (43%), Gaps = 27/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +R RE Q+L E T Q+ E+E +R A+ ++ ++ +QL
Sbjct: 1659 EQAVRQRELAEQELEKQRQLAEGTA-------QQRLAAEQELIR--LRAETEQGEQQRQL 1709
Query: 390 LQLQVFQLQQEK----RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
L+ ++ +LQ+E ++ Q+ A+L + R ++E A+ R + E E++K +
Sbjct: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
Query: 446 KSGEISLLKQQLKESQAELVQ-KGSELVALRVALREARATLRVSEGRARGLQEAARAR-- 502
++G L ++ +A + K +A A R+ RV + + EA R +
Sbjct: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1829
Query: 503 -ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E+ L+ E +R R+ AE + +L+ +AA + + A L ++ +++++
Sbjct: 1830 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA-QHKADIEERLAQ---LRKASDSELE 1885
Query: 562 RAAAGVGGSL--RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
R V +L R QVE + L+ + + E E ++ E +R ++Q +
Sbjct: 1886 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1945
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQA 656
R RQL E ++ E E R L E+A
Sbjct: 1946 E----AARQRQLAAEEERRRREAEERVQKSLAAEEEA 1978
Score = 44.3 bits (103), Expect = 4e-04
Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 26/265 (9%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALREDCAAQAQR 382
+L+ E + Q L E +A E+ QRER E L +D A+AQ+
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2507
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+ QQ Q Q ++QE+++L + + + + E + E ++L + + +
Sbjct: 2508 LREEQQRQQQQ---MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2564
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ + Q L+E + E+ A +VA AT + GR AA
Sbjct: 2565 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA-----ATKTLPNGRDALDGPAA--- 2616
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E E L+R + A++L+E AG L AE L+ T D E +Q
Sbjct: 2617 EAEPEHSFDGLRR-KVSAQRLQE-AGILSAEE--LQRLAQGHTTVDELARREDVRHYLQG 2672
Query: 563 AAAGVGGSLRAQVERLRV--ELQRE 585
++ G L+A E+L V LQR+
Sbjct: 2673 RSSIAGLLLKATNEKLSVYAALQRQ 2697
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/322 (22%), Positives = 134/322 (41%), Gaps = 26/322 (8%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQRER--EALREDCAAQAQRAQRAQQLLQLQVFQ 396
E Q + +L E EAT + R + ++ +ALR++ AQ + LQ + +
Sbjct: 1092 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG----AQEVGERLQQRHGE 1147
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQ 456
E + ++ AQLL+ + + + +RE +LG +L + + + + Q
Sbjct: 1148 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR----ESADPLGAWLQD 1203
Query: 457 LKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQ-ELQ 514
+ Q ++ ++ A+R LR+ +A L E ++E R + + A ELQ
Sbjct: 1204 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQ 1263
Query: 515 RHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQ 574
+A QL+ A+ ++P V + ++
Sbjct: 1264 LVTYKA--------QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1315
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
E LR ++ E R E+QR + E ERL AE E + Q+QL + Q + + +E
Sbjct: 1316 SETLR-RMEEEERLAEQQR-AEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKE 1370
Query: 635 LQQ-LSLELEARELADLGLAEQ 655
LQQ + E+ RE A + +Q
Sbjct: 1371 LQQRMQEEVVRREEAAVDAQQQ 1392
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 28/328 (8%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL--REDCAAQAQRAQRAQQL 389
+L + EA L++ R + + QA E + QR +E + RE+ A AQ+ +R+ Q
Sbjct: 1347 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1406
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+LQQ ++ + + ++ E ER +E E R + +LE T+ + GE
Sbjct: 1407 ------ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1460
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE----GRARGLQEAARARELE 505
+ L+ + +E++A+ Q E LR +++ R +E R + EAAR ++
Sbjct: 1461 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1520
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQRA 563
L+A L+ R +AE+ + Q + E A R+ V TA AE S A
Sbjct: 1521 LQA----LEELRLQAEEAERRLRQAEVERA--RQVQVALETAQRSAEAELQSKRASFAEK 1574
Query: 564 AAGVGGSLRAQ---VERLRVELQR---ERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL 617
A + SL+ + V +LR E +R ++ E R+ E E WQ + + +R +L
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RL 1632
Query: 618 QHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q + + Q E E Q+ E EAR
Sbjct: 1633 QAEEVAQQKSLAQAEAEKQKEEAEREAR 1660
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/336 (29%), Positives = 151/336 (44%), Gaps = 41/336 (12%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMC--QAYEERQRHW--QREREALREDCAAQAQRAQR 385
E + EAE + R L NEA QA E Q+ Q E E +E+ +A+R +
Sbjct: 1605 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1664
Query: 386 AQQLLQLQVFQLQQE---KRQLQDDFAQ--LLQEREQLERRCATLEREQRELGPRLEETK 440
A++ Q +QE +RQL + AQ L E+E + R T + EQ+ LEE
Sbjct: 1665 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR--QLLEE-- 1720
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV----ALREARATLRVSEGRARGLQ 496
E+ + E + Q+ +E +AEL + +E+ L A E+R+T S+ R
Sbjct: 1721 -ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-- 1777
Query: 497 EAARAREL-----ELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
EA R REL L A ++E +R RQ AE E A + AEA + + L
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAE---EDAARQRAEAERVLAEKLAAIGEATRL 1834
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG---ERLA-WQAEK 607
E++ A ++ A ++ RL + +RRR EEQ + ERLA +
Sbjct: 1835 KTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1888
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
+ + QK L + + R+ RQ+E+E+ L E
Sbjct: 1889 DSELERQKGLVEDTL---RQRRQVEEEILALKASFE 1921
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 42/342 (12%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
++ L E +Q + +L+E E + E R+ + E+E+ R+ AQ +R Q
Sbjct: 1976 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2035
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ F +QQ++++LQ Q +QL R E + + E Q
Sbjct: 2036 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2095
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ ++LK+S E Q ++ A LR + +E A +A +A + +A
Sbjct: 2096 QVE-EAERLKQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQA 2148
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
E+++H++ AEQ + Q++ E LR L E+D K
Sbjct: 2149 ADAEMEKHKKFAEQTLRQKAQVEQELTTLR-----------LQLEETDHQK--------- 2188
Query: 569 GSLRAQVERLR---VELQRERRRGEE-------QRDSFEGERLAWQAEKEQVIRYQKQLQ 618
L +++RL+ E R+R + EE Q + + +AE +I K
Sbjct: 2189 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2248
Query: 619 HNYIQ-MYRRNRQLEQELQQLSLELE----ARELADLGLAEQ 655
++Q + +Q+ +E +LS+ + R+LA+ LA+Q
Sbjct: 2249 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2290
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/377 (23%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 333 LRDREAELQQLRDSLD------ENEATMCQAYEERQRHWQRERE------ALREDCAAQA 380
LRD++ + L++ + E A + A +E R Q E AL E +
Sbjct: 2242 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2301
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA--------TLERE---Q 429
+A + L+ + LQQ+K Q+ +L +++EQ+ ++ A TLE E Q
Sbjct: 2302 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2361
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATL---- 485
E+ E K V + S + ++ + + + + G +L +A +E + TL
Sbjct: 2362 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTL 2420
Query: 486 ----RVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREP 540
+ S+ A L+EA E E E QE + + ++E+++ + QL E L++
Sbjct: 2421 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2480
Query: 541 PVPPATADPFL----LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-- 594
+ + D L E ++AK+++ + A+ ++LR E QR++++ E++R
Sbjct: 2481 FL--SEKDSLLQRERFIEQEKAKLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRL 2534
Query: 595 --SFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
S E R +E V R Q++LQ Q ++ L +E Q+L +L+ E
Sbjct: 2535 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-----E 2589
Query: 653 AEQAPCICLEEITATEI 669
+A EE+TA+++
Sbjct: 2590 QHRAALAHSEEVTASQV 2606
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 49/350 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
L+++EAE ++LR L E+EA + EE+ + + E +R QL +
Sbjct: 1842 LKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIE-------------ERLAQLRKA 1887
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEV--CQKSGEI 450
+L+++K ++D L++R Q+E L+ + E + E+ + + E
Sbjct: 1888 SDSELERQKGLVEDT----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE--- 507
+L ++ QAEL +A R A RV + A +EAAR R+ LE
Sbjct: 1944 TLRSKE----QAELEAARQRQLAAEEERRRREAEERVQKSLAAE-EEAARQRKAALEEVE 1998
Query: 508 ---ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAA 564
A +E +R R+ AEQ + QL EAA R A A E + + +
Sbjct: 1999 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2058
Query: 565 AGVGGSLRAQVERLR--------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ 616
V LR + E R +Q ER + +R E ERL AE++ R Q Q
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2118
Query: 617 -----LQHNYIQMYRRNRQLEQ----ELQQLSLELEA-RELADLGLAEQA 656
L+ Q R Q EQ + Q E+E ++ A+ L ++A
Sbjct: 2119 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2168
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/351 (24%), Positives = 157/351 (44%), Gaps = 29/351 (8%)
Query: 336 REAELQQL-------RDSLDENEATMCQAYEERQR-------HWQREREALREDCAAQAQ 381
R+ EL+QL R+S D A + A +++ Q RE LR++ A +
Sbjct: 1184 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1243
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKW 441
+ +++ + Q F +Q ++D QL+ + QLE + ++ + + G ++
Sbjct: 1244 IERHGEKVEECQRFA-KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1302
Query: 442 -EVCQKSGEISLLKQQLKESQAELVQKGSELVAL----RVALREARATLRVSEGRARGLQ 496
++ E++ L Q + +E +++ E L R RE A + + + R L
Sbjct: 1303 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1362
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
EA + + E ++ELQ+ QE E +R + +DA+ ++ + +E++
Sbjct: 1363 EAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAE 1418
Query: 557 -EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK 615
+AK ++A A LR + E V LQ E E QR EGE A +A E+ ++
Sbjct: 1419 IQAKARQAEAAERSRLRIEEEIRVVRLQLEAT--ERQRGGAEGELQALRARAEEAEAQKR 1476
Query: 616 QLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLA--EQAPCICLEEI 664
Q Q ++ R+ + Q +Q +EL +R A+ A +Q LEE+
Sbjct: 1477 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1527
Score = 50.4 bits (119), Expect = 5e-06
Identities = 77/337 (22%), Positives = 147/337 (43%), Gaps = 27/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +R RE Q+L E T Q+ E+E +R A+ ++ ++ +QL
Sbjct: 1667 EQAVRQRELAEQELEKQRQLAEGTA-------QQRLAAEQELIR--LRAETEQGEQQRQL 1717
Query: 390 LQLQVFQLQQEK----RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
L+ ++ +LQ+E ++ Q+ A+L + R ++E A+ R + E E++K +
Sbjct: 1718 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1777
Query: 446 KSGEISLLKQQLKESQAELVQ-KGSELVALRVALREARATLRVSEGRARGLQEAARAR-- 502
++G L ++ +A + K +A A R+ RV + + EA R +
Sbjct: 1778 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1837
Query: 503 -ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E+ L+ E +R R+ AE + +L+ +AA + + A L ++ +++++
Sbjct: 1838 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA-QHKADIEERLAQ---LRKASDSELE 1893
Query: 562 RAAAGVGGSL--RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
R V +L R QVE + L+ + + E E ++ E +R ++Q +
Sbjct: 1894 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1953
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQA 656
R RQL E ++ E E R L E+A
Sbjct: 1954 E----AARQRQLAAEEERRRREAEERVQKSLAAEEEA 1986
Score = 44.3 bits (103), Expect = 4e-04
Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 26/265 (9%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALREDCAAQAQR 382
+L+ E + Q L E +A E+ QRER E L +D A+AQ+
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2515
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+ QQ Q Q ++QE+++L + + + + E + E ++L + + +
Sbjct: 2516 LREEQQRQQQQ---MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2572
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ + Q L+E + E+ A +VA AT + GR AA
Sbjct: 2573 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA-----ATKTLPNGRDALDGPAA--- 2624
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E E L+R + A++L+E AG L AE L+ T D E +Q
Sbjct: 2625 EAEPEHSFDGLRR-KVSAQRLQE-AGILSAEE--LQRLAQGHTTVDELARREDVRHYLQG 2680
Query: 563 AAAGVGGSLRAQVERLRV--ELQRE 585
++ G L+A E+L V LQR+
Sbjct: 2681 RSSIAGLLLKATNEKLSVYAALQRQ 2705
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/322 (22%), Positives = 134/322 (41%), Gaps = 26/322 (8%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQRER--EALREDCAAQAQRAQRAQQLLQLQVFQ 396
E Q + +L E EAT + R + ++ +ALR++ AQ + LQ + +
Sbjct: 1100 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG----AQEVGERLQQRHGE 1155
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQ 456
E + ++ AQLL+ + + + +RE +LG +L + + + + Q
Sbjct: 1156 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR----ESADPLGAWLQD 1211
Query: 457 LKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQ-ELQ 514
+ Q ++ ++ A+R LR+ +A L E ++E R + + A ELQ
Sbjct: 1212 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQ 1271
Query: 515 RHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQ 574
+A QL+ A+ ++P V + ++
Sbjct: 1272 LVTYKA--------QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1323
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
E LR ++ E R E+QR + E ERL AE E + Q+QL + Q + + +E
Sbjct: 1324 SETLR-RMEEEERLAEQQR-AEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKE 1378
Query: 635 LQQ-LSLELEARELADLGLAEQ 655
LQQ + E+ RE A + +Q
Sbjct: 1379 LQQRMQEEVVRREEAAVDAQQQ 1400
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 80.9 bits (198), Expect = 4e-15
Identities = 88/328 (26%), Positives = 149/328 (45%), Gaps = 28/328 (8%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL--REDCAAQAQRAQRAQQL 389
+L + EA L++ R + + QA E + QR +E + RE+ A AQ+ +R+ Q
Sbjct: 1388 RLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE 1447
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+LQQ ++ + + ++ E ER +E E R + +LE T+ + GE
Sbjct: 1448 ------ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE 1501
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE----GRARGLQEAARARELE 505
+ L+ + +E++A+ Q E LR +++ R +E R + EAAR ++
Sbjct: 1502 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRA 1561
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQRA 563
L+A L+ R +AE+ + Q + E A R+ V TA AE S A
Sbjct: 1562 LQA----LEELRLQAEEAERRLRQAEVERA--RQVQVALETAQRSAEAELQSKRASFAEK 1615
Query: 564 AAGVGGSLRAQ---VERLRVELQR---ERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL 617
A + SL+ + V +LR E +R ++ E R+ E E WQ + + +R +L
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL--RL 1673
Query: 618 QHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q + + Q E E Q+ E EAR
Sbjct: 1674 QAEEVAQQKSLAQAEAEKQKEEAEREAR 1701
Score = 65.1 bits (157), Expect = 2e-10
Identities = 98/336 (29%), Positives = 151/336 (44%), Gaps = 41/336 (12%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMC--QAYEERQRHW--QREREALREDCAAQAQRAQR 385
E + EAE + R L NEA QA E Q+ Q E E +E+ +A+R +
Sbjct: 1646 EAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGK 1705
Query: 386 AQQLLQLQVFQLQQE---KRQLQDDFAQ--LLQEREQLERRCATLEREQRELGPRLEETK 440
A++ Q +QE +RQL + AQ L E+E + R T + EQ+ LEE
Sbjct: 1706 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR--QLLEE-- 1761
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRV----ALREARATLRVSEGRARGLQ 496
E+ + E + Q+ +E +AEL + +E+ L A E+R+T S+ R
Sbjct: 1762 -ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA-- 1818
Query: 497 EAARAREL-----ELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFL 551
EA R REL L A ++E +R RQ AE E A + AEA + + L
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAE---EDAARQRAEAERVLAEKLAAIGEATRL 1875
Query: 552 LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG---ERLA-WQAEK 607
E++ A ++ A ++ RL + +RRR EEQ + ERLA +
Sbjct: 1876 KTEAEIALKEKEAE------NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKAS 1929
Query: 608 EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
+ + QK L + + R+ RQ+E+E+ L E
Sbjct: 1930 DSELERQKGLVEDTL---RQRRQVEEEILALKASFE 1962
Score = 64.7 bits (156), Expect = 3e-10
Identities = 77/342 (22%), Positives = 143/342 (41%), Gaps = 42/342 (12%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
++ L E +Q + +L+E E + E R+ + E+E+ R+ AQ +R Q
Sbjct: 2017 VQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA 2076
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ F +QQ++++LQ Q +QL R E + + E Q
Sbjct: 2077 EEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRR 2136
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
++ ++LK+S E Q ++ A LR + +E A +A +A + +A
Sbjct: 2137 QVE-EAERLKQSAEEQAQARAQAQAAAEKLR------KEAEQEAARRAQAEQAALRQKQA 2189
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
E+++H++ AEQ + Q++ E LR L E+D K
Sbjct: 2190 ADAEMEKHKKFAEQTLRQKAQVEQELTTLR-----------LQLEETDHQK--------- 2229
Query: 569 GSLRAQVERLR---VELQRERRRGEE-------QRDSFEGERLAWQAEKEQVIRYQKQLQ 618
L +++RL+ E R+R + EE Q + + +AE +I K
Sbjct: 2230 NLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNT 2289
Query: 619 HNYIQ-MYRRNRQLEQELQQLSLELE----ARELADLGLAEQ 655
++Q + +Q+ +E +LS+ + R+LA+ LA+Q
Sbjct: 2290 QRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2331
Score = 60.5 bits (145), Expect = 5e-09
Identities = 90/377 (23%), Positives = 169/377 (44%), Gaps = 52/377 (13%)
Query: 333 LRDREAELQQLRDSLD------ENEATMCQAYEERQRHWQRERE------ALREDCAAQA 380
LRD++ + L++ + E A + A +E R Q E AL E +
Sbjct: 2283 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2342
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA--------TLERE---Q 429
+A + L+ + LQQ+K Q+ +L +++EQ+ ++ A TLE E Q
Sbjct: 2343 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQ 2402
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATL---- 485
E+ E K V + S + ++ + + + + G +L +A +E + TL
Sbjct: 2403 LEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTL 2461
Query: 486 ----RVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREP 540
+ S+ A L+EA E E E QE + + ++E+++ + QL E L++
Sbjct: 2462 EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQS 2521
Query: 541 PVPPATADPFL----LAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-- 594
+ + D L E ++AK+++ + A+ ++LR E QR++++ E++R
Sbjct: 2522 FL--SEKDSLLQRERFIEQEKAKLEQ----LFQDEVAKAQQLREEQQRQQQQMEQERQRL 2575
Query: 595 --SFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
S E R +E V R Q++LQ Q ++ L +E Q+L +L+ E
Sbjct: 2576 VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-----E 2630
Query: 653 AEQAPCICLEEITATEI 669
+A EE+TA+++
Sbjct: 2631 QHRAALAHSEEVTASQV 2647
Score = 59.7 bits (143), Expect = 8e-09
Identities = 91/350 (26%), Positives = 146/350 (41%), Gaps = 49/350 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
L+++EAE ++LR L E+EA + EE+ + + E +R QL +
Sbjct: 1883 LKEKEAENERLR-RLAEDEAFQRRRLEEQAAQHKADIE-------------ERLAQLRKA 1928
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEV--CQKSGEI 450
+L+++K ++D L++R Q+E L+ + E + E+ + + E
Sbjct: 1929 SDSELERQKGLVEDT----LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1984
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE--- 507
+L ++ QAEL +A R A RV + A +EAAR R+ LE
Sbjct: 1985 TLRSKE----QAELEAARQRQLAAEEERRRREAEERVQKSLAAE-EEAARQRKAALEEVE 2039
Query: 508 ---ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAA 564
A +E +R R+ AEQ + QL EAA R A A E + + +
Sbjct: 2040 RLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQE 2099
Query: 565 AGVGGSLRAQVERLR--------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ 616
V LR + E R +Q ER + +R E ERL AE++ R Q Q
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQ 2159
Query: 617 -----LQHNYIQMYRRNRQLEQ----ELQQLSLELEA-RELADLGLAEQA 656
L+ Q R Q EQ + Q E+E ++ A+ L ++A
Sbjct: 2160 AAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2209
Score = 57.4 bits (137), Expect = 4e-08
Identities = 85/351 (24%), Positives = 157/351 (44%), Gaps = 29/351 (8%)
Query: 336 REAELQQL-------RDSLDENEATMCQAYEERQR-------HWQREREALREDCAAQAQ 381
R+ EL+QL R+S D A + A +++ Q RE LR++ A +
Sbjct: 1225 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1284
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKW 441
+ +++ + Q F +Q ++D QL+ + QLE + ++ + + G ++
Sbjct: 1285 IERHGEKVEECQRFA-KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEY 1343
Query: 442 -EVCQKSGEISLLKQQLKESQAELVQKGSELVAL----RVALREARATLRVSEGRARGLQ 496
++ E++ L Q + +E +++ E L R RE A + + + R L
Sbjct: 1344 VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLA 1403
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
EA + + E ++ELQ+ QE E +R + +DA+ ++ + +E++
Sbjct: 1404 EAHAQAKAQAEREAKELQQRMQE-EVVRREEAAVDAQQ---QKRSIQEELQQLRQSSEAE 1459
Query: 557 -EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK 615
+AK ++A A LR + E V LQ E E QR EGE A +A E+ ++
Sbjct: 1460 IQAKARQAEAAERSRLRIEEEIRVVRLQLEAT--ERQRGGAEGELQALRARAEEAEAQKR 1517
Query: 616 QLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLA--EQAPCICLEEI 664
Q Q ++ R+ + Q +Q +EL +R A+ A +Q LEE+
Sbjct: 1518 QAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL 1568
Score = 50.4 bits (119), Expect = 5e-06
Identities = 77/337 (22%), Positives = 147/337 (43%), Gaps = 27/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +R RE Q+L E T Q+ E+E +R A+ ++ ++ +QL
Sbjct: 1708 EQAVRQRELAEQELEKQRQLAEGTA-------QQRLAAEQELIR--LRAETEQGEQQRQL 1758
Query: 390 LQLQVFQLQQEK----RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
L+ ++ +LQ+E ++ Q+ A+L + R ++E A+ R + E E++K +
Sbjct: 1759 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1818
Query: 446 KSGEISLLKQQLKESQAELVQ-KGSELVALRVALREARATLRVSEGRARGLQEAARAR-- 502
++G L ++ +A + K +A A R+ RV + + EA R +
Sbjct: 1819 EAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTE 1878
Query: 503 -ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E+ L+ E +R R+ AE + +L+ +AA + + A L ++ +++++
Sbjct: 1879 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA-QHKADIEERLAQ---LRKASDSELE 1934
Query: 562 RAAAGVGGSL--RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
R V +L R QVE + L+ + + E E ++ E +R ++Q +
Sbjct: 1935 RQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAEL 1994
Query: 620 NYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQA 656
R RQL E ++ E E R L E+A
Sbjct: 1995 E----AARQRQLAAEEERRRREAEERVQKSLAAEEEA 2027
Score = 44.3 bits (103), Expect = 4e-04
Identities = 67/265 (25%), Positives = 113/265 (42%), Gaps = 26/265 (9%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALREDCAAQAQR 382
+L+ E + Q L E +A E+ QRER E L +D A+AQ+
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQ 2556
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+ QQ Q Q ++QE+++L + + + + E + E ++L + + +
Sbjct: 2557 LREEQQRQQQQ---MEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEEL 2613
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ + Q L+E + E+ A +VA AT + GR AA
Sbjct: 2614 LAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA-----ATKTLPNGRDALDGPAA--- 2665
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E E L+R + A++L+E AG L AE L+ T D E +Q
Sbjct: 2666 EAEPEHSFDGLRR-KVSAQRLQE-AGILSAEE--LQRLAQGHTTVDELARREDVRHYLQG 2721
Query: 563 AAAGVGGSLRAQVERLRV--ELQRE 585
++ G L+A E+L V LQR+
Sbjct: 2722 RSSIAGLLLKATNEKLSVYAALQRQ 2746
Score = 42.7 bits (99), Expect = 0.001
Identities = 74/322 (22%), Positives = 134/322 (41%), Gaps = 26/322 (8%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQRER--EALREDCAAQAQRAQRAQQLLQLQVFQ 396
E Q + +L E EAT + R + ++ +ALR++ AQ + LQ + +
Sbjct: 1141 EAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRG----AQEVGERLQQRHGE 1196
Query: 397 LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQ 456
E + ++ AQLL+ + + + +RE +LG +L + + + + Q
Sbjct: 1197 RDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYR----ESADPLGAWLQD 1252
Query: 457 LKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQ-ELQ 514
+ Q ++ ++ A+R LR+ +A L E ++E R + + A ELQ
Sbjct: 1253 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQ 1312
Query: 515 RHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQ 574
+A QL+ A+ ++P V + ++
Sbjct: 1313 LVTYKA--------QLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFI 1364
Query: 575 VERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQE 634
E LR ++ E R E+QR + E ERL AE E + Q+QL + Q + + +E
Sbjct: 1365 SETLR-RMEEEERLAEQQR-AEERERL---AEVEAALEKQRQLAEAHAQAKAQAEREAKE 1419
Query: 635 LQQ-LSLELEARELADLGLAEQ 655
LQQ + E+ RE A + +Q
Sbjct: 1420 LQQRMQEEVVRREEAAVDAQQQ 1441
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 77.8 bits (190), Expect = 3e-14
Identities = 103/439 (23%), Positives = 194/439 (44%), Gaps = 54/439 (12%)
Query: 240 TSSPGGHLPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTR 299
T++ LP+ + G + P+G + +G SSS+ + +A ++ +
Sbjct: 124 TTAKTSKLPTRPASTGVAGASSSLGPSGSA--SAGELSSSEPSTPAQTPLAAPIIPTPVL 181
Query: 300 ASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYE 359
SP + PP P P +E L ++RD E +L+ LR E++A + + +
Sbjct: 182 TSPGAV------PPLPSPSKEEEGL-----RAQVRDLEEKLETLRLKRAEDKAKLKELEK 230
Query: 360 -----ERQRHWQREREALREDCAAQAQRAQR-AQQLLQLQVFQLQQEKRQLQDDFAQLLQ 413
E+ + W+ + + + D + + A++ A++ L+ + + +E D
Sbjct: 231 HKIQLEQVQEWKSKMQEQQADLQRRLKEARKEAKEALEAKE-RYMEEMADTADAIEMATL 289
Query: 414 EREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVA 473
++E E R +L++E L R++E L L+ +AE+ +KGS+ A
Sbjct: 290 DKEMAEERAESLQQEVEALKERVDE--------------LTTDLEILKAEIEEKGSDGAA 335
Query: 474 LRVALR---EARATLRVSEGRARGLQEAARARELEL----EACSQELQRHRQEAEQLREK 526
L+ E A L+ + R R L + + ++L E +QEL+ RQ+ E+L+E+
Sbjct: 336 SSYQLKQLEEQNARLKDALVRMRDLSSSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEE 395
Query: 527 AGQLDAEAAGLREPPVPPATADPFLLAESD-----EAKVQRAAAGVGGSLRAQVERLRVE 581
Q ++ L+E A+ + +D E KV+ VG L A E + E
Sbjct: 396 LSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEEKVRELRETVG-DLEAMNE-MNDE 453
Query: 582 LQRERRRGE-EQRDSFE--GERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQL 638
LQ R E E R+ + G R+ E ++ + ++ +Y Q ++ RQL LQ +
Sbjct: 454 LQENARETELELREQLDMAGARVR---EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDV 510
Query: 639 SLELEARELADLGLAEQAP 657
+ EL ++ A + +Q P
Sbjct: 511 NRELTNQQEASVERQQQPP 529
>gi|195947367 golgi autoantigen, golgin subfamily a, 8B [Homo
sapiens]
Length = 603
Score = 77.4 bits (189), Expect = 4e-14
Identities = 96/419 (22%), Positives = 179/419 (42%), Gaps = 65/419 (15%)
Query: 263 GVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDE 322
GVP + SS ++ S GG S +S SS +SP ++
Sbjct: 27 GVPAAAKRNTKANGSSPETAAS------GGCHSSEASSSASSSLHARQSPC------QEQ 74
Query: 323 ALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQR 382
A + L R ++ +L D++ ++ Q ++ + + E++A E
Sbjct: 75 AAV-------LNSRSIKISRLNDTIK----SLKQQKKQVEHQLEEEKKANNEK------- 116
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
Q+A++ L+ Q+ +L EK++L D + E L + R+ E +W
Sbjct: 117 -QKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAGRLQRSSQRIGELEWS 175
Query: 443 VCQ------------KSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEG 490
+C S +LLK+QL++S E + + L+ +L+E +
Sbjct: 176 LCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQLKESLKEVQLERDQYAE 235
Query: 491 RARG--LQEAARARELELEACS--QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPAT 546
+ +G Q R R++ E C+ +E + E+L +L + A P+PP
Sbjct: 236 QIKGERAQWQQRMRKMSQEVCTLKEEKKHDTHRVEELERSLSRLKNQMA----EPLPPDA 291
Query: 547 ADPFLLAESDEAKVQRAAAGVGGSLRAQVER-----LRVELQRERRRGEEQRDSFEGERL 601
P + +E + +++ V G L+AQVE L Q+ER R +E+R + ERL
Sbjct: 292 --PAVSSEVELQDLRKELERVAGELQAQVENNQCISLLNRGQKERLREQEERLQEQQERL 349
Query: 602 AWQAEKEQVIRYQKQLQHNYIQMYRRNR---QLEQELQQLSLELEARELADLGLAEQAP 657
E+E+ ++ + Q + ++ N+ QLEQ++++L +L + + L AE+ P
Sbjct: 350 ---REREKRLQQLAEPQSDLEELKHENKSALQLEQQVKELQEKL-GQVMETLTSAEKEP 404
>gi|31083099 golgi autoantigen, golgin subfamily a, 8A [Homo
sapiens]
Length = 603
Score = 77.4 bits (189), Expect = 4e-14
Identities = 96/419 (22%), Positives = 179/419 (42%), Gaps = 65/419 (15%)
Query: 263 GVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDE 322
GVP + SS ++ S GG S +S SS +SP ++
Sbjct: 27 GVPAAAKRNTKANGSSPETAAS------GGCHSSEASSSASSSLHARQSPC------QEQ 74
Query: 323 ALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQR 382
A + L R ++ +L D++ ++ Q ++ + + E++A E
Sbjct: 75 AAV-------LNSRSIKISRLNDTIK----SLKQQKKQVEHQLEEEKKANNEK------- 116
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
Q+A++ L+ Q+ +L EK++L D + E L + R+ E +W
Sbjct: 117 -QKAERELEGQIQRLNTEKKKLNTDLYHMKHSLRYFEEESKDLAGRLQRSSQRIGELEWS 175
Query: 443 VCQ------------KSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEG 490
+C S +LLK+QL++S E + + L+ +L+E +
Sbjct: 176 LCAVAATQKKKPDGFSSRSKALLKRQLEQSIREQILLKGHVTQLKESLKEVQLERDQYAE 235
Query: 491 RARG--LQEAARARELELEACS--QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPAT 546
+ +G Q R R++ E C+ +E + E+L +L + A P+PP
Sbjct: 236 QIKGERAQWQQRMRKMSQEVCTLKEEKKHDTHRVEELERSLSRLKNQMA----EPLPPDA 291
Query: 547 ADPFLLAESDEAKVQRAAAGVGGSLRAQVER-----LRVELQRERRRGEEQRDSFEGERL 601
P + +E + +++ V G L+AQVE L Q+ER R +E+R + ERL
Sbjct: 292 --PAVSSEVELQDLRKELERVAGELQAQVENNQCISLLNRGQKERLREQEERLQEQQERL 349
Query: 602 AWQAEKEQVIRYQKQLQHNYIQMYRRNR---QLEQELQQLSLELEARELADLGLAEQAP 657
E+E+ ++ + Q + ++ N+ QLEQ++++L +L + + L AE+ P
Sbjct: 350 ---REREKRLQQLAEPQSDLEELKHENKSALQLEQQVKELQEKL-GQVMETLTSAEKEP 404
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 77.4 bits (189), Expect = 4e-14
Identities = 102/413 (24%), Positives = 185/413 (44%), Gaps = 53/413 (12%)
Query: 267 GPSHSDS-GRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALL 325
GPS S S G SSS+ + +A ++ + SP + PP P P +E L
Sbjct: 34 GPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAV------PPLPSPSKEEEGL- 86
Query: 326 HCVLEGKLRDREAELQQLRDSLDENEATMCQAYE-----ERQRHWQREREALREDCAAQA 380
++RD E +L+ LR E++A + + + E+ + W+ + + + D +
Sbjct: 87 ----RAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
Query: 381 QRAQR-AQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEET 439
+ A++ A++ L+ + + +E D ++E E R +L++E L R++E
Sbjct: 143 KEARKEAKEALEAKE-RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE- 200
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALR---EARATLRVSEGRARGLQ 496
L L+ +AE+ +KGS+ A L+ E A L+ + R R L
Sbjct: 201 -------------LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 247
Query: 497 EAARARELEL----EACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLL 552
+ + ++L E +QEL+ RQ+ E+L+E+ Q ++ L+E A+ +
Sbjct: 248 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 307
Query: 553 AESD-----EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGE-EQRDSFE--GERLAWQ 604
+D E KV+ VG L A E + ELQ R E E R+ + G R+
Sbjct: 308 MLTDRNLNLEEKVRELRETVG-DLEAMNE-MNDELQENARETELELREQLDMAGARVR-- 363
Query: 605 AEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAP 657
E ++ + ++ +Y Q ++ RQL LQ ++ EL ++ A + +Q P
Sbjct: 364 -EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 415
Score = 29.6 bits (65), Expect = 9.4
Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 7/60 (11%)
Query: 145 PTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLA 204
PTA K +P+ P+ P+ +TG++G+ SL A SSS S+ A PLA
Sbjct: 6 PTARKTTTRRPK--PTRPA-----STGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLA 58
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 77.4 bits (189), Expect = 4e-14
Identities = 102/413 (24%), Positives = 185/413 (44%), Gaps = 53/413 (12%)
Query: 267 GPSHSDS-GRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALL 325
GPS S S G SSS+ + +A ++ + SP + PP P P +E L
Sbjct: 34 GPSGSASAGELSSSEPSTPAQTPLAAPIIPTPVLTSPGAV------PPLPSPSKEEEGL- 86
Query: 326 HCVLEGKLRDREAELQQLRDSLDENEATMCQAYE-----ERQRHWQREREALREDCAAQA 380
++RD E +L+ LR E++A + + + E+ + W+ + + + D +
Sbjct: 87 ----RAQVRDLEEKLETLRLKRAEDKAKLKELEKHKIQLEQVQEWKSKMQEQQADLQRRL 142
Query: 381 QRAQR-AQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEET 439
+ A++ A++ L+ + + +E D ++E E R +L++E L R++E
Sbjct: 143 KEARKEAKEALEAKE-RYMEEMADTADAIEMATLDKEMAEERAESLQQEVEALKERVDE- 200
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALR---EARATLRVSEGRARGLQ 496
L L+ +AE+ +KGS+ A L+ E A L+ + R R L
Sbjct: 201 -------------LTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLS 247
Query: 497 EAARARELEL----EACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLL 552
+ + ++L E +QEL+ RQ+ E+L+E+ Q ++ L+E A+ +
Sbjct: 248 SSEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVE 307
Query: 553 AESD-----EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGE-EQRDSFE--GERLAWQ 604
+D E KV+ VG L A E + ELQ R E E R+ + G R+
Sbjct: 308 MLTDRNLNLEEKVRELRETVG-DLEAMNE-MNDELQENARETELELREQLDMAGARVR-- 363
Query: 605 AEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAP 657
E ++ + ++ +Y Q ++ RQL LQ ++ EL ++ A + +Q P
Sbjct: 364 -EAQKRVEAAQETVADYQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPP 415
Score = 29.6 bits (65), Expect = 9.4
Identities = 21/60 (35%), Positives = 30/60 (50%), Gaps = 7/60 (11%)
Query: 145 PTAFKPVLPKPRGAPSLPSFMGPRATGLSGSQGSLTQLFGGPASSSSSSSSSSAADKPLA 204
PTA K +P+ P+ P+ +TG++G+ SL A SSS S+ A PLA
Sbjct: 6 PTARKTTTRRPK--PTRPA-----STGVAGASSSLGPSGSASAGELSSSEPSTPAQTPLA 58
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 75.5 bits (184), Expect = 1e-13
Identities = 94/343 (27%), Positives = 149/343 (43%), Gaps = 32/343 (9%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQR-EREALR---EDCAAQAQRAQR 385
E + R RE L++ + L E E + +E + ++ ER+ LR ++ Q QR +R
Sbjct: 243 EKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRR 302
Query: 386 AQQLLQLQVFQL---------QQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRL 436
QQL + Q + QQE+R+ Q++ + REQ ERR L REQ
Sbjct: 303 EQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE------ 356
Query: 437 EETKWEVCQKSGEISLLKQQL-KESQAELVQKGSELVALRVALREARATLRVSEGRARGL 495
EE + + ++ E +QQL +E Q Q+ LR + R E + R
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 416
Query: 496 QEAARARELELEACSQELQRHRQEAEQLRE----KAGQLDAEAAGLREPPVPPATAD--- 548
Q+ R ++L E QE +RH Q+ EQ R K Q + RE +
Sbjct: 417 QQLRREQQLRRE---QEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRK 473
Query: 549 PFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQR--DSFEGERLAWQAE 606
L + +E + +R R Q ER +L+RE+ EQR E ERL +
Sbjct: 474 QQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLR 533
Query: 607 KEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELAD 649
EQ +R +++ + + ++LEQE ++ L+ E E D
Sbjct: 534 SEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRD 576
Score = 74.3 bits (181), Expect = 3e-13
Identities = 89/329 (27%), Positives = 150/329 (45%), Gaps = 35/329 (10%)
Query: 334 RDREAELQQLRDSLDENEATMCQAYEE---RQRHWQREREALREDCAAQAQRAQRAQQLL 390
++ E QQLR +E E+ R++ +RE++ RE + Q+ +R QQL
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 414
Query: 391 QLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEI 450
+ Q + +Q+ R+ Q++ + +++ + ERR L+REQ E R + K E + E
Sbjct: 415 REQQLRREQQLRREQEE--ERHEQKHEQERREQRLKREQEE---RRDWLKREEETERHEQ 469
Query: 451 SLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACS 510
KQQLK Q E ++ L++ E R E + R QE R + L+ +
Sbjct: 470 ERRKQQLKRDQEEERRER----WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 511 QELQRHRQEAEQL-------------REKAGQLDAEAAGLREPPVPPATADPFLLAESDE 557
+ LQ+ + +QL RE+ +L+ E R D LL +E
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQ-LLKREEE 584
Query: 558 AKVQRAAAGVGGSL-----RAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIR 612
+ QR L R +VERL E +RE+R E+ + ++L E+E+ R
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE--R 642
Query: 613 YQKQLQHNYIQMYRRNRQLEQELQQLSLE 641
Q+QL+ Q RR ++L++E ++ LE
Sbjct: 643 RQQQLRRE--QQERREQRLKREEEEERLE 669
Score = 73.6 bits (179), Expect = 6e-13
Identities = 92/328 (28%), Positives = 149/328 (45%), Gaps = 34/328 (10%)
Query: 334 RDREAELQQLRDSLDENEATMCQAYEERQRHWQ--------REREALREDCAAQAQRAQR 385
R+R +LQ+ D L E++ + R + W+ R R L A Q Q ++
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ-LRK 901
Query: 386 AQQLLQLQVFQLQQEKRQLQDDFAQLLQ--EREQLERRCATLEREQRELGPRLEET---- 439
QQLLQ + +LQ+E+R+ + Q Q E EQL++ L RE+RE R E
Sbjct: 902 EQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYR 961
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVS-EGRARGLQEA 498
K + Q+ E L ++ K + E +K E L+ +E LR E R R E
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQ---QEEEQLLREEREKRRRQEWER 1018
Query: 499 ARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEA 558
++ EL+ ++L R +E +L+E+ Q E +E + LL E E
Sbjct: 1019 QYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQE--------EEQLLGEERET 1070
Query: 559 KVQRAAAGV---GGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQ- 614
+ ++ L+ + E+L E +RRR E +R E E L Q E+EQ++R +
Sbjct: 1071 RRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL--QQEEEQLLREER 1128
Query: 615 -KQLQHNYIQMYRRNRQLEQELQQLSLE 641
K+ + + YR +++QE +QL E
Sbjct: 1129 EKRRRQELERQYREEEEVQQEEEQLLRE 1156
Score = 70.1 bits (170), Expect = 6e-12
Identities = 89/322 (27%), Positives = 144/322 (44%), Gaps = 31/322 (9%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRH-----WQREREALREDCAAQAQRAQ 384
E K R RE+ELQ E E Q EE QR WQ E ++ R A+
Sbjct: 736 EEKRRRRESELQW-----QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPL 790
Query: 385 RAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVC 444
R Q+ QL+ + QQ +++ L +E E+ +RR ERE +EL EE + +
Sbjct: 791 REQRERQLRAEERQQREQRF------LPEEEEKEQRRRQRRERE-KELQFLEEEEQLQRR 843
Query: 445 QKSGEISLLKQQLKESQAEL-VQKGSELVALRVALREARATLRVSEGRARGLQEAARARE 503
+++ ++ + L+E Q Q+ R L E R R + LQE R +
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903
Query: 504 LELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRA 563
L+ +ELQR +E + +E+ Q E +E + L E ++ + Q
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE-------EQLLREEREKRRRQER 956
Query: 564 AAGV--GGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQ--KQLQH 619
L+ + E+L E +RRR E ++ E E L Q E+EQ++R + K+ +
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEEL--QQEEEQLLREEREKRRRQ 1014
Query: 620 NYIQMYRRNRQLEQELQQLSLE 641
+ + YR+ +L+QE +QL E
Sbjct: 1015 EWERQYRKKDELQQEEEQLLRE 1036
Score = 68.9 bits (167), Expect = 1e-11
Identities = 86/337 (25%), Positives = 141/337 (41%), Gaps = 30/337 (8%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E L+DR E Q R + + RQ+ ++ERE A+ + Q+
Sbjct: 107 ESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL------AEGEEQSEKQER 160
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
L+ Q+++++ ++ + QE ++ E R A E+ Q G EE E + E
Sbjct: 161 LE------QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEAC 509
+ L+++ +E + + ++ + V +E R V LQE R+ EL+
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 510 S--------QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
QEL+R RQE EQ +++ LR E E + Q
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRL----RREQQLRRKQEEERREQQEERREQQERREQ 330
Query: 562 RAAAGVGGSLRAQVERLRVELQRER---RRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQ 618
+ R Q ER +L+RE+ RR ++ R E ER Q +EQ +R ++QL+
Sbjct: 331 QEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLR 390
Query: 619 HNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQ 655
Q RR +QL +E QQL E + R L +Q
Sbjct: 391 RE--QQLRREQQLRRE-QQLRREQQLRREQQLRREQQ 424
Score = 67.4 bits (163), Expect = 4e-11
Identities = 83/316 (26%), Positives = 147/316 (46%), Gaps = 50/316 (15%)
Query: 330 EGKLRDREAELQQLRDS--LDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQ 387
E + R R+ + +Q R+ L + E + + E++R +RER+ R+D Q Q+ +
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQ-YRKDKKLQ----QKEE 971
Query: 388 QLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKS 447
QLL + EKR+ Q+ + +E E+L++ L RE+RE R E WE +
Sbjct: 972 QLL-----GEEPEKRRRQER-EKKYREEEELQQEEEQLLREEREKRRRQE---WERQYRK 1022
Query: 448 GEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE 507
K +L++ + +L+++ E L+ R+ R + + + L E R
Sbjct: 1023 ------KDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR---- 1072
Query: 508 ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGV 567
QEL+R ++ E+L+++ QL LRE P E + +
Sbjct: 1073 --RQELERQYRKEEELQQEEEQL------LREEP------------EKRRRQERERQCRE 1112
Query: 568 GGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRY--QKQLQHNYIQMY 625
L+ + E+L E + +RRR E +R E E + Q E+EQ++R +K+ + + Y
Sbjct: 1113 EEELQQEEEQLLREEREKRRRQELERQYREEEEV--QQEEEQLLREEPEKRRRQELERQY 1170
Query: 626 RRNRQLEQELQQLSLE 641
R +L+QE +QL E
Sbjct: 1171 REEEELQQEEEQLLRE 1186
Score = 67.0 bits (162), Expect = 5e-11
Identities = 83/337 (24%), Positives = 153/337 (45%), Gaps = 39/337 (11%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQ 391
+LR + E ++ R +E E + Q + +RE+E E+ Q Q +R + +
Sbjct: 646 QLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEE---QEQARERIKSRIP 702
Query: 392 LQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEIS 451
+QL+ E Q +++E RR E+ +R R E +W+ +++
Sbjct: 703 KWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRR----RESELQWQEEERAHRQQ 758
Query: 452 LLKQQLKE-----SQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELEL 506
++Q ++ E ++G + ++ R LRE R +E R + Q E +
Sbjct: 759 QEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKE 818
Query: 507 EACSQELQRHRQ-----EAEQL--REKAGQLDAEAAGLREPPVPPATADP-----FLLAE 554
+ Q +R ++ E EQL RE+A QL E GL+E + + +
Sbjct: 819 QRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQL 878
Query: 555 SDEAKVQRAAAGVGGSLRAQVERLRV-------ELQRE----RRRGEEQRDSFEGERLAW 603
+E K +R +L+ Q+ + + ELQRE RRR E++R E E+L
Sbjct: 879 EEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL-- 936
Query: 604 QAEKEQVIRYQ--KQLQHNYIQMYRRNRQLEQELQQL 638
Q E+EQ++R + K+ + + YR++++L+Q+ +QL
Sbjct: 937 QQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL 973
Score = 65.9 bits (159), Expect = 1e-10
Identities = 93/347 (26%), Positives = 150/347 (43%), Gaps = 39/347 (11%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +L+ R QQLR +E + + EE++ +R + L+ + + + + ++
Sbjct: 525 EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+ Q + +QE+R Q + ++ EQ ERR L+RE+ E R + K E ++ +
Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR------- 502
L ++Q +E + + +++ E L L+ R + A QE AR R
Sbjct: 645 QQLRREQ-QERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPK 703
Query: 503 ---ELELEACS-----------QELQRHRQEAEQ---LREKAGQLDAEAAGLREPPVPPA 545
+LE EA + QE QR RQE E+ RE Q E R+
Sbjct: 704 WQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQ 763
Query: 546 TAD---PFLLAESDEAKVQRAAAGVGGSLRAQVER-LRVE--LQRERRRGEEQRDSFEGE 599
D + E E QR +A LR Q ER LR E QRE+R E+ + +
Sbjct: 764 RRDFTWQWQAEEKSERGRQRLSA--RPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821
Query: 600 RLAWQAEKE-QVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEAR 645
R + EKE Q + ++QLQ R +QL++E L + E R
Sbjct: 822 RQRREREKELQFLEEEEQLQRR-----ERAQQLQEEEDGLQEDQERR 863
Score = 64.7 bits (156), Expect = 3e-10
Identities = 84/327 (25%), Positives = 149/327 (45%), Gaps = 36/327 (11%)
Query: 334 RDRE-AELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
RDR+ E +QLR +E + + +ER R ++ E + +R Q ++ +Q L+
Sbjct: 1553 RDRKFREEEQLRQEREEQQLSR----QERDRKFRLEEQKVRRQ--EQERKFMEDEQQLRR 1606
Query: 393 QVFQ--LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEI 450
Q Q L+QE+ + + QLLQERE+ + L R++R+ EE + ++ ++
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQ-----LHRQERDRKFLEEEPQLRRQEREQQL 1661
Query: 451 SLLKQQLKESQAELVQKGSELVALRVA----LREARATLRVSEGRARGLQEAARARELEL 506
+ + + +L+Q+G E R RE LR E + LQE + R EL
Sbjct: 1662 RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQEL 1721
Query: 507 EACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKV----QR 562
E +E ++ RQE EQ E+ + + L E + P + L + + K Q
Sbjct: 1722 ERKFREEEQLRQETEQ--EQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQL 1779
Query: 563 AAAGVGGSLRAQV--------ERLRVELQRERRRGEEQRDSFEGERLAWQAEK-EQVIRY 613
LR+Q E+LR E + ++ R +++ + E Q E+ EQ +R
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839
Query: 614 QKQLQHNYIQMY---RRNRQLEQELQQ 637
++ Q+ + + ++R+ EQEL Q
Sbjct: 1840 ERDRQYRAEEQFATQEKSRREEQELWQ 1866
Score = 62.8 bits (151), Expect = 1e-09
Identities = 80/357 (22%), Positives = 150/357 (42%), Gaps = 47/357 (13%)
Query: 330 EGKLRDREAEL--QQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQ 387
E K + E +L QQ + + E + + +QR R+R+ E+ Q + Q+
Sbjct: 1514 ERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLS 1573
Query: 388 QLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERR------------------CATLEREQ 429
+ + + F+L+++K + Q+ + +++ +QL R+ ERE+
Sbjct: 1574 RQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREE 1633
Query: 430 RELGPRLEETKWEVCQKSGEISLLKQQLK-------ESQAELVQKGSELVALRV----AL 478
++L + + K+ + +QQL+ + +L+Q+G E R
Sbjct: 1634 QQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693
Query: 479 REARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLR 538
RE LR E + LQE + R ELE +E ++ RQE EQ E+ + + L
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQ--EQLRRQERYRKILE 1751
Query: 539 EPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG 598
E + P + L + + K + + E+LR E + ++ R +E F
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFR------------EEEQLRQEREEQQLRSQESDRKFRE 1799
Query: 599 ERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQ 655
E Q +EQ +R Q+ + + QLE++ Q+L E + + A+ A Q
Sbjct: 1800 EEQLRQEREEQQLRPQQ--RDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ 1854
Score = 62.4 bits (150), Expect = 1e-09
Identities = 85/325 (26%), Positives = 145/325 (44%), Gaps = 20/325 (6%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHW---QREREALREDCAAQAQRAQRA 386
E + R + E ++ R+ + E + + EER+ Q E E L++ ++ Q+ +R
Sbjct: 483 ERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE-QQLRRE 541
Query: 387 QQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRL---EETKWEV 443
Q+ + Q+ + ++EKR Q+ Q L +REQ ERR L+RE+ RL +E + E
Sbjct: 542 QEERREQLLKREEEKRLEQERREQRL-KREQEERRDQLLKREEERRQQRLKREQEERLEQ 600
Query: 444 CQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGR--ARGLQEAARA 501
K E+ L+Q+ + Q ++ E ++ E + R + R + +E
Sbjct: 601 RLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Query: 502 RELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
RE E E Q L+R +E + +E A + +A + +P A++ ++KV
Sbjct: 661 REEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVY 720
Query: 562 RAAAGVGGSLRAQVE-----RLRVELQ-RERRRGEEQRDSFEGER---LAWQAEKEQVIR 612
G R Q + R ELQ +E R Q+ E R WQAE E+ R
Sbjct: 721 SRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE-EKSER 779
Query: 613 YQKQLQHNYIQMYRRNRQLEQELQQ 637
+++L +R RQL E +Q
Sbjct: 780 GRQRLSARPPLREQRERQLRAEERQ 804
Score = 61.2 bits (147), Expect = 3e-09
Identities = 85/335 (25%), Positives = 151/335 (45%), Gaps = 38/335 (11%)
Query: 330 EGKLRDREAE--LQQLRDSLDENEATM-CQAYEERQRHWQREREALREDCAAQAQRAQRA 386
+ +LRDR+++ LQ L E + + +++R RH+ E + RE+ +R +++
Sbjct: 1255 DSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKS 1314
Query: 387 QQLLQLQVFQLQQEKRQLQDDFAQLLQEREQL--ERRCATLEREQRELGPRLEETKWEVC 444
Q+ QL + ++++R+ + D + +E EQL ER L R++R+ R EE +
Sbjct: 1315 QEEKQLLREEREEKRRRQETD--RKFREEEQLLQEREEQPLRRQERDRKFREEELRH--- 1369
Query: 445 QKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAREL 504
Q+ G L ++Q Q + E LR RE + LR R + RE
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQ--LRQDRDR--------KFREE 1419
Query: 505 ELEACSQELQR-HRQEAEQLR--EKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQ 561
E + QE R R+E +Q+R E+ + E LR+ + LL E +E ++
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLH 1479
Query: 562 RAAAGVGGSLRAQVERLRVELQRERRRGEEQRD-SFEGERLAWQAEKEQVIRYQKQLQHN 620
R ER R L+ E++ ++RD F + L Q + + + ++QL
Sbjct: 1480 RQ------------ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527
Query: 621 YIQMYRRNRQLEQELQQLSLELEARELADLGLAEQ 655
Q R+ Q EQ+L++ + R+ D E+
Sbjct: 1528 --QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREE 1560
Score = 58.2 bits (139), Expect = 2e-08
Identities = 74/310 (23%), Positives = 143/310 (46%), Gaps = 40/310 (12%)
Query: 334 RDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQ 393
R+RE ELQ L+E E + ER + Q E + L+ED Q +R + Q+ Q
Sbjct: 825 REREKELQ----FLEEEEQLQRR---ERAQQLQEEEDGLQED---QERRRSQEQRRDQKW 874
Query: 394 VFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLL 453
+QL++E+++ + +EQL + L+ E+ EL + EE + Q+
Sbjct: 875 RWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL--QREEREKRRRQEQERQYRE 932
Query: 454 KQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQEL 513
++QL++ + +L+++ E + R+ R ++ + + L E R QE
Sbjct: 933 EEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR------RQER 986
Query: 514 QRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRA 573
++ +E E+L+++ QL E R + E + ++ L+
Sbjct: 987 EKKYREEEELQQEEEQLLREEREKRR-------------RQEWERQYRKK-----DELQQ 1028
Query: 574 QVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQL--QHNYIQMYRRNRQL 631
+ E+L E +RE+RR +E+ + E Q E+EQ++ +++ + + YR+ +L
Sbjct: 1029 EEEQLLRE-EREKRRLQERERQYREEE-ELQQEEEQLLGEERETRRRQELERQYRKEEEL 1086
Query: 632 EQELQQLSLE 641
+QE +QL E
Sbjct: 1087 QQEEEQLLRE 1096
Score = 56.2 bits (134), Expect = 9e-08
Identities = 80/314 (25%), Positives = 130/314 (41%), Gaps = 44/314 (14%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHWQREREALR-------EDCAAQAQRAQRAQQLLQ 391
E ++ RD L E T E R++ +R++E R E+ + Q+ +R QQL +
Sbjct: 450 EQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRR 509
Query: 392 LQV------FQLQQEKRQLQDDFAQLLQ-EREQLERRCATLEREQRELGPRLEETKWEVC 444
Q + Q+E+ +LQ Q REQ ERR L+RE+ + RLE+ + E
Sbjct: 510 EQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK---RLEQERRE-- 564
Query: 445 QKSGEISLLKQQLKESQAELVQKGSELVALRVAL-REARATLRVSEGRARGLQEAARARE 503
LK++ +E + +L+++ E R+ +E R R+ L++ R RE
Sbjct: 565 ------QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEER-RE 617
Query: 504 LELEACSQELQRHRQ---EAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKV 560
L+ E +R +Q EQ + QL E RE L E +E ++
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQR---------LKREEEEERL 668
Query: 561 QRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHN 620
++ + ER EL E + +R + WQ E E R K
Sbjct: 669 EQRL-----KREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723
Query: 621 YIQMYRRNRQLEQE 634
Q +R RQ ++E
Sbjct: 724 RKQEGQRRRQEQEE 737
Score = 56.2 bits (134), Expect = 9e-08
Identities = 98/373 (26%), Positives = 153/373 (41%), Gaps = 84/373 (22%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQ-REREALREDCAAQAQRAQRAQQ 388
E K + E +L+Q R E + Q EE+Q H Q R+R+ L E+ Q R Q +
Sbjct: 1445 ERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEE---QQLRRQERDR 1501
Query: 389 LLQLQVFQLQQEKRQLQDDFAQL---------LQEREQLERR------------------ 421
+ Q + Q+ +R+ ++ QL LQE +QL R+
Sbjct: 1502 KFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEE 1561
Query: 422 CATLEREQRELGP-------RLEETKWEVCQKSGEISLLKQQLK--ESQAELVQKGSELV 472
ERE+++L RLEE K ++ + +QQL+ E Q +L Q+
Sbjct: 1562 QLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR-- 1619
Query: 473 ALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDA 532
RE L+ E ++ +E + + +E Q RQE EQ
Sbjct: 1620 ----KFREDEQLLQERE------EQQLHRQERDRKFLEEEPQLRRQEREQ---------- 1659
Query: 533 EAAGLREPPVPPATADPFLLAESDEAKVQRAAAG-----VGGSLRAQVERLRVELQRER- 586
LR + LL E +E +++R LR Q ER R LQ E+
Sbjct: 1660 ---QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ-ERERKFLQEEQQ 1715
Query: 587 -RRGEEQRDSFEGERLAWQAEKEQV---IRYQKQLQHNYIQMYRRNRQLE--------QE 634
RR E +R E E+L + E+EQ+ RY+K L+ ++ R +QL +E
Sbjct: 1716 LRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFRE 1775
Query: 635 LQQLSLELEAREL 647
+QL E E ++L
Sbjct: 1776 EEQLRQEREEQQL 1788
Score = 53.9 bits (128), Expect = 5e-07
Identities = 73/275 (26%), Positives = 113/275 (41%), Gaps = 41/275 (14%)
Query: 393 QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISL 452
Q L +EKR D LLQ+R Q E +QR PR + + E Q+
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQ--------EEDQRRFEPRDRQLEEEPGQR------ 136
Query: 453 LKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQ-----EAARARELELE 507
++Q ++ Q + +G E + L E R R E R Q E RA E +L+
Sbjct: 137 -RRQKRQEQERELAEGEEQSEKQERL-EQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 508 ACS--------QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADP-----FLLAE 554
+C E Q R+E +LR K + + R+ V + +
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 555 SDEAKVQRAAAGVGGSLRAQVERL----RVELQRERRRGEEQRDSFEGERLAWQAEKEQV 610
+E K+Q L+ + E+L R EL+RER+ E+Q+ E+ Q ++Q
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQ---QLRRKQE 311
Query: 611 IRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEAR 645
++Q + Q RR +Q E+ QQL E E R
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEER 346
Score = 48.5 bits (114), Expect = 2e-05
Identities = 94/361 (26%), Positives = 151/361 (41%), Gaps = 55/361 (15%)
Query: 336 REAELQQLRDSLDENEAT---------MCQAYEERQRHWQR----EREALREDCAAQAQR 382
+E ELQQ + L E C+ EE Q+ ++ ERE R + R
Sbjct: 1082 KEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYR 1141
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQD------DFAQLLQEREQLERRCATLEREQRELGPRL 436
+ Q + Q+ + + EKR+ Q+ + +L QE EQL R R++RE R
Sbjct: 1142 EEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYRE 1201
Query: 437 EETKWEVCQK-----SGEISLLKQQLKESQAELVQ------KGSELVALRVALREARATL 485
EE +K + S LK Q + + V+ KG E R L +++
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFR-QLEDSQLRD 1260
Query: 486 RVSEGRARGLQEAARARELELEACS-QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPP 544
R S+ + L + R+ E E Q+ RH E EQL E+ Q +A+ +
Sbjct: 1261 RQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQL-EREEQKEAKRRDRK------ 1313
Query: 545 ATADPFLLAESDEAKVQRAAAGVGGSLRAQV--ERLRVELQRERR---------RGEEQR 593
+ + LL E E K +R Q+ ER L+R+ R R +EQ
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQG 1373
Query: 594 DSF--EGERLAWQAEKEQVIRYQKQL--QHNYIQMYR-RNRQLEQELQQLSLELEARELA 648
F E +RL Q + + ++ ++QL Q Q+ + R+R+ +E QQLS + R+
Sbjct: 1374 RKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433
Query: 649 D 649
+
Sbjct: 1434 E 1434
Score = 42.0 bits (97), Expect = 0.002
Identities = 38/142 (26%), Positives = 69/142 (48%), Gaps = 10/142 (7%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
E +LR E Q R D Q +ER+ R +E+ R+ + R +R +Q
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 390 LQLQV----FQLQQEKRQLQDDFAQLLQERE---QLERRCATLE---REQRELGPRLEET 439
L+ Q ++ ++E+ QL++ +L QER+ + E + AT E RE++EL E+
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Query: 440 KWEVCQKSGEISLLKQQLKESQ 461
+ + ++ +++Q KE Q
Sbjct: 1872 RRQERERKLREEHIRRQQKEEQ 1893
Score = 34.3 bits (77), Expect = 0.38
Identities = 38/153 (24%), Positives = 67/153 (43%), Gaps = 13/153 (8%)
Query: 334 RDRE-AELQQLRDSLDENEATMCQA----YEERQRHWQREREALREDCAAQAQRAQRAQQ 388
RDR+ E +QLR +E + ++ EE Q +RE + LR R + Q
Sbjct: 1769 RDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQL 1828
Query: 389 LLQLQVFQLQQEK-RQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVC--- 444
L+ Q +L+QE+ RQ + + QE+ + E + E EQ+ R + + E
Sbjct: 1829 QLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQ 1888
Query: 445 ----QKSGEISLLKQQLKESQAELVQKGSELVA 473
Q+ ++ +K Q + L++ G+ A
Sbjct: 1889 QKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFA 1921
>gi|239745083 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 4 [Homo sapiens]
Length = 590
Score = 73.9 bits (180), Expect = 4e-13
Identities = 91/382 (23%), Positives = 163/382 (42%), Gaps = 47/382 (12%)
Query: 273 SGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGK 332
+G + K+ GS+ G G +SP SSS S P P E V+
Sbjct: 30 AGAKRNRKTNGSIHETATSG----GCHSSPHSSSTS--SSLHAPQSPCQEL---AVVPDS 80
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
+ ++L+ SL + + + EE ++ +++A RE Q QR + L
Sbjct: 81 RSVKVSQLKNTIKSLKQQKKQVVHQLEEEKKANNEKQKAERE-LEVQIQRLNIQKGKLNT 139
Query: 393 QVFQLQQEKRQLQDDFAQL-------LQEREQLERRCATLEREQRELGPRLEE-----TK 440
++ ++ R +++ L LQ + +LER + + Q++ R T+
Sbjct: 140 DLYHTKRSLRYFEEESKDLAVRLQHSLQRKGELERALSAVTATQKKKAERFSSRSKARTE 199
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAAR 500
W++ Q E +LLK QL + + L + V L + RAR Q R
Sbjct: 200 WKLEQSMREQALLKAQLTQLKESLKE---------VQLERDEYAEHLKGERARWQQ---R 247
Query: 501 ARELELEACS--QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEA 558
R++ E CS +E + + E L +L + A PP PPA +E++
Sbjct: 248 MRKMSQEVCSLKKEKKHDKYRVETLERSLSKLKNQMAEPL-PPEPPAVP-----SEAELQ 301
Query: 559 KVQRAAAGVGGSLRAQVE-----RLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRY 613
+++ V G+L+AQVE L E Q+ER R +++R + ERL AE + +
Sbjct: 302 HLRKELERVAGALQAQVEYNQRISLLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKE 361
Query: 614 QKQLQHNYIQMYRRNRQLEQEL 635
+ +Q+ ++ ++L+++L
Sbjct: 362 LNNENKSVLQLEQQVKELQEKL 383
Score = 32.7 bits (73), Expect = 1.1
Identities = 42/205 (20%), Positives = 85/205 (41%), Gaps = 12/205 (5%)
Query: 446 KSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELE 505
+S ++S LK +K + + Q +L + A E + R E + + L +
Sbjct: 81 RSVKVSQLKNTIKSLKQQKKQVVHQLEEEKKANNEKQKAERELEVQIQRLNIQKGKLNTD 140
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQ-- 561
L + L+ +E++ L + Q + G E + TA AE S +K +
Sbjct: 141 LYHTKRSLRYFEEESKDLAVRL-QHSLQRKGELERALSAVTATQKKKAERFSSRSKARTE 199
Query: 562 ---RAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAE----KEQVIRYQ 614
+ L+AQ+ +L+ L+ + +E + +GER WQ ++V +
Sbjct: 200 WKLEQSMREQALLKAQLTQLKESLKEVQLERDEYAEHLKGERARWQQRMRKMSQEVCSLK 259
Query: 615 KQLQHNYIQMYRRNRQLEQELQQLS 639
K+ +H+ ++ R L + Q++
Sbjct: 260 KEKKHDKYRVETLERSLSKLKNQMA 284
>gi|239745081 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 2 [Homo sapiens]
Length = 629
Score = 73.9 bits (180), Expect = 4e-13
Identities = 93/397 (23%), Positives = 169/397 (42%), Gaps = 47/397 (11%)
Query: 273 SGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGK 332
+G + K+ GS+ G G + DSSS S P P E V+
Sbjct: 42 AGAKRNRKTNGSIHETATSG----GCHSPGDSSSTS--SSLHAPQSPCQEL---AVVPDS 92
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
+ ++L+ SL + + + EE ++ +++A RE Q QR + L
Sbjct: 93 RSVKVSQLKNTIKSLKQQKKQVVHQLEEEKKANNEKQKAERE-LEVQIQRLNIQKGKLNT 151
Query: 393 QVFQLQQEKRQLQDDFAQL-------LQEREQLERRCATLEREQRELGPRLEE-----TK 440
++ ++ R +++ L LQ + +LER + + Q++ R T+
Sbjct: 152 DLYHTKRSLRYFEEESKDLAVRLQHSLQRKGELERALSAVTATQKKKAERFSSRSKARTE 211
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAAR 500
W++ Q E +LLK QL + + L + V L + RAR Q R
Sbjct: 212 WKLEQSMREQALLKAQLTQLKESLKE---------VQLERDEYAEHLKGERARWQQ---R 259
Query: 501 ARELELEACS--QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEA 558
R++ E CS +E + + E L +L + A PP PPA +E++
Sbjct: 260 MRKMSQEVCSLKKEKKHDKYRVETLERSLSKLKNQMAEPL-PPEPPAVP-----SEAELQ 313
Query: 559 KVQRAAAGVGGSLRAQVE-----RLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRY 613
+++ V G+L+AQVE L E Q+ER R +++R + ERL AE + +
Sbjct: 314 HLRKELERVAGALQAQVEYNQRISLLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKE 373
Query: 614 QKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADL 650
+ +Q+ ++ ++L+++L + LE +++ L
Sbjct: 374 LNNENKSVLQLEQQVKELQEKLGKERLEAASQQKQQL 410
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 73.2 bits (178), Expect = 7e-13
Identities = 91/405 (22%), Positives = 176/405 (43%), Gaps = 41/405 (10%)
Query: 247 LPSHGSGRGALPGPARGVPTGPSHSDSGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSS 306
L G G L G + G + R+SS + ++ V + TR
Sbjct: 32 LEDGGPGPDTLSGGSGGSESQEEEEPQERNSSPQRP-AVSAPVGASEIAEETRPGQRELQ 90
Query: 307 CGE-RSPPPPPPPPSDEALLHCV--LEGKLRDREAELQQLRDSLDENEATMCQAYEERQR 363
+ P P P E L LE + + ++ QQL E ++ + +
Sbjct: 91 LQQLEQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPEL 150
Query: 364 HWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQ---EKRQLQDDFAQ---LLQEREQ 417
+++ L+ + QR Q+ Q+ LQ Q Q QQ ++ QLQ + L Q++EQ
Sbjct: 151 QLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQ 210
Query: 418 LERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVA 477
L+++ L ++Q +L + + + E Q+ ++ LL+QQ + Q +L+Q+
Sbjct: 211 LQQQ--QLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQ-GQLQQQLLQQ---------- 257
Query: 478 LREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGL 537
++A+ ++ E + LQ+ ++ E Q+ Q +Q+ EQL+++ L
Sbjct: 258 -QQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQ---------L 307
Query: 538 REPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFE 597
+ PP+ P E +E +++ +G + +R +E Q+E R +EQR
Sbjct: 308 QPPPLEP--------EEEEEVELELMPVDLGSEQELEQQRQELERQQELERQQEQRQLQL 359
Query: 598 GERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLEL 642
+ Q ++Q+ + Q+QL+ +Q+ +L + Q++ LEL
Sbjct: 360 KLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLEL 404
Score = 71.6 bits (174), Expect = 2e-12
Identities = 88/387 (22%), Positives = 170/387 (43%), Gaps = 59/387 (15%)
Query: 295 GSGTRASPDSSSCGERSPPPPPPPPSDEA-LLHCVLEGKLRDREAELQQLRDSLDENEAT 353
GSG S + ER+ P P S E + RE +LQQL + +
Sbjct: 45 GSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQLEQQPEPQQQP 104
Query: 354 MCQAYEERQRHWQREREALREDCAAQAQRAQRA------------------QQLLQLQVF 395
+ ++ Q H + +++ ++ +Q Q QQ LQ Q
Sbjct: 105 QHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQV 164
Query: 396 Q----LQQEKRQLQDDFAQ---LLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
Q LQQ++ QLQ AQ +LQ++EQL+++ +EQ+ L + E+ + + +
Sbjct: 165 QEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQV----QEQQLLQQQQEQLQQQQLLQQQ 220
Query: 449 EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEA 508
E L+QQ + Q E +Q+ +L+ L+ + + L+ + + + Q+ ++ +L+
Sbjct: 221 E--QLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQ--QQLLEQQQAQLQ- 275
Query: 509 CSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVG 568
Q+L +QE Q +++ L + L++ + P +P E +E +++ +G
Sbjct: 276 --QQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEP---EEEEEVELELMPVDLG 330
Query: 569 GSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRN 628
+ +R +E Q+E R +EQR + Q +LQ Q+ ++
Sbjct: 331 SEQELEQQRQELERQQELERQQEQR------------------QLQLKLQEELQQLEQQL 372
Query: 629 RQLEQELQQLSLELEARELADLGLAEQ 655
Q +Q+L+Q ++LE + +LG +Q
Sbjct: 373 EQQQQQLEQQEVQLELTPV-ELGAQQQ 398
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/121 (28%), Positives = 59/121 (48%), Gaps = 10/121 (8%)
Query: 340 LQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQ 399
LQQ ++ L + + E + + E E + D ++ + Q+ Q+L + Q + QQ
Sbjct: 295 LQQQQEQLQQQQLQPPPLEPEEEE--EVELELMPVDLGSEQELEQQRQELERQQELERQQ 352
Query: 400 EKRQLQDDFA--------QLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEIS 451
E+RQLQ QL Q+++QLE++ LE ELG + +E + E+ E+
Sbjct: 353 EQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQ 412
Query: 452 L 452
L
Sbjct: 413 L 413
Score = 37.4 bits (85), Expect = 0.045
Identities = 35/122 (28%), Positives = 57/122 (46%), Gaps = 14/122 (11%)
Query: 314 PPPPPPSDEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALR 373
PPP P +E + L E EL+Q R L ERQ+ +R++E +
Sbjct: 309 PPPLEPEEEEEVELELMPVDLGSEQELEQQRQEL------------ERQQELERQQEQRQ 356
Query: 374 EDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLERE-QREL 432
Q + Q QQL Q Q QL+Q++ QL+ +L ++++++ ++ E Q EL
Sbjct: 357 LQLKLQEELQQLEQQLEQQQQ-QLEQQEVQLELTPVELGAQQQEVQLELTPVQPELQLEL 415
Query: 433 GP 434
P
Sbjct: 416 VP 417
Score = 29.6 bits (65), Expect = 9.4
Identities = 21/83 (25%), Positives = 44/83 (53%), Gaps = 12/83 (14%)
Query: 574 QVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQ 633
Q E+L+ ++Q ++ ++Q Q +++Q+++ Q+QLQ Q ++ QL+Q
Sbjct: 190 QQEQLQQQVQEQQLLQQQQE----------QLQQQQLLQQQEQLQQQ--QFQQQQEQLQQ 237
Query: 634 ELQQLSLELEARELADLGLAEQA 656
+ Q L L+ + + L +QA
Sbjct: 238 QQQLLLLQQQGQLQQQLLQQQQA 260
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 72.4 bits (176), Expect = 1e-12
Identities = 60/317 (18%), Positives = 152/317 (47%), Gaps = 12/317 (3%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQ 391
+L+++ AELQ+ ++ ++ + +E +R + ++ L ++ + Q Q +Q Q
Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQ 67
Query: 392 L--QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGE 449
+ Q Q+++++ Q+++ Q+ ++ Q+ + E + RE ++ E + +V ++ G+
Sbjct: 68 VREQEGQVREQEGQVREQEGQVREQEGQVREQ----EGQVREQEGQVREQEGQVREQEGQ 123
Query: 450 ISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEAC 509
+ + Q++E + ++ ++ ++ +RE +R EG+ R ++ + RE E +
Sbjct: 124 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR--EQEGQVREQEGQVR 181
Query: 510 SQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGG 569
QE Q QE Q+ E+ GQ+ + + E + + + ++ + Q G
Sbjct: 182 EQEGQVREQEG-QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG--- 237
Query: 570 SLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNR 629
QV++ ++Q++ + +Q + + + ++EQ+++ ++Q + + +
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 630 QLEQELQQLSLELEARE 646
EQE Q E + RE
Sbjct: 298 MREQEEQMREQEEQMRE 314
Score = 70.5 bits (171), Expect = 5e-12
Identities = 62/320 (19%), Positives = 157/320 (49%), Gaps = 17/320 (5%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
EG++R++E ++++ + E E Q E+ + ++E + ++ + Q Q +Q
Sbjct: 65 EGQVREQEGQVREQEGQVREQEG---QVREQEGQVREQEGQVREQEGQVREQEGQVREQE 121
Query: 390 LQL--QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKS 447
Q+ Q Q+++++ Q+++ Q+ ++ Q+ + E + RE ++ E + +V ++
Sbjct: 122 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQ----EGQVREQEGQVREQEGQVREQE 177
Query: 448 GEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELELE 507
G++ + Q++E + ++ ++ ++ + E ++ E + +E R +E ++
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237
Query: 508 ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGV 567
QE Q +QE EQ++++ Q+ + +RE + +L + ++ + +
Sbjct: 238 --EQEEQVQKQE-EQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294
Query: 568 GGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRR 627
+R Q E++R + ++ R + E+ R+ E ++EQ+ ++Q+ QM+++
Sbjct: 295 EEQMREQEEQMREQEEQMREQEEQMREQEE----QMGKQEEQMWEQKEQMWEQKEQMWKQ 350
Query: 628 NRQL-EQELQQLSLELEARE 646
Q+ EQE Q E + R+
Sbjct: 351 EEQMGEQEEQMQKQEEQVRK 370
Score = 65.1 bits (157), Expect = 2e-10
Identities = 44/219 (20%), Positives = 113/219 (51%), Gaps = 13/219 (5%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL 389
EG++ ++E ++ + + + + E M + EE+ R + + E Q ++ Q+ ++
Sbjct: 198 EGQMGEQEEQMGEQEEQMQKQEEQMGEQ-EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQ 256
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQ---------RELGPRLEETK 440
++ Q Q+++++ Q+++ Q+L+++EQ E+ T E+E+ RE ++ E +
Sbjct: 257 MRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQE 316
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAAR 500
++ ++ ++ ++Q+ E + ++ ++ ++ + E ++ E + R +E R
Sbjct: 317 EQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR 376
Query: 501 ARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLRE 539
+E ++ QE Q +QE EQ+ E+ Q+ + +RE
Sbjct: 377 KQEEQMR--KQEEQMRKQE-EQMGEQKEQMGEQKEQMRE 412
Score = 63.9 bits (154), Expect = 5e-10
Identities = 60/324 (18%), Positives = 159/324 (49%), Gaps = 22/324 (6%)
Query: 328 VLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQ---REREALREDCAAQAQRAQ 384
++E + + + +++L+ L+ ++ + Q + R++ Q +E + ++ + Q Q
Sbjct: 22 LVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 81
Query: 385 RAQQLLQL--QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+Q Q+ Q Q+++++ Q+++ Q+ ++ Q+ + E + RE ++ E + +
Sbjct: 82 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ----EGQVREQEGQVREQEGQ 137
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
V ++ G++ + Q++E + ++ ++ ++ +RE +R EG+ R ++ +
Sbjct: 138 VREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR--EQEGQMG 195
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
E E + QE Q QE EQ++++ Q+ + +R+ + + + ++ + Q
Sbjct: 196 EQEGQMGEQEEQMGEQE-EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQE 254
Query: 563 AAAGVGGSLRAQVERLRVELQRERRRGEE---QRDSFEGERLAWQAEKEQVIRYQKQLQH 619
+R Q E++R + ++ R + E+ Q++ E E + E EQ+ ++Q++
Sbjct: 255 E------QMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQE-EQMREQEEQMRE 307
Query: 620 NYIQMYRRNRQLEQELQQLSLELE 643
QM + Q+ ++ +Q+ + E
Sbjct: 308 QEEQMREQEEQMREQEEQMGKQEE 331
Score = 41.6 bits (96), Expect = 0.002
Identities = 18/113 (15%), Positives = 65/113 (57%), Gaps = 5/113 (4%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRERE--ALREDCAAQAQRAQRAQ 387
E ++R++E ++ + + + E + Q +E++++ W++E + E Q ++ ++ +
Sbjct: 316 EEQMREQEEQMGKQEEQMWEQKE---QMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQE 372
Query: 388 QLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETK 440
+ ++ Q Q+++++ Q++ Q+ +++EQ+ + + ++ ++G + E+ +
Sbjct: 373 EQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMR 425
>gi|239745085 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 3 [Homo sapiens]
Length = 601
Score = 71.2 bits (173), Expect = 3e-12
Identities = 90/382 (23%), Positives = 162/382 (42%), Gaps = 47/382 (12%)
Query: 273 SGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGK 332
+G + K+ GS+ G G + DSSS S P P E V+
Sbjct: 42 AGAKRNRKTNGSIHETATSG----GCHSPGDSSSTS--SSLHAPQSPCQEL---AVVPDS 92
Query: 333 LRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQL 392
+ ++L+ SL + + + EE ++ +++A RE Q QR + L
Sbjct: 93 RSVKVSQLKNTIKSLKQQKKQVVHQLEEEKKANNEKQKAERE-LEVQIQRLNIQKGKLNT 151
Query: 393 QVFQLQQEKRQLQDDFAQL-------LQEREQLERRCATLEREQRELGPRLEE-----TK 440
++ ++ R +++ L LQ + +LER + + Q++ R T+
Sbjct: 152 DLYHTKRSLRYFEEESKDLAVRLQHSLQRKGELERALSAVTATQKKKAERFSSRSKARTE 211
Query: 441 WEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAAR 500
W++ Q E +LLK QL + + L + V L + RAR Q R
Sbjct: 212 WKLEQSMREQALLKAQLTQLKESLKE---------VQLERDEYAEHLKGERARWQQ---R 259
Query: 501 ARELELEACS--QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEA 558
R++ E CS +E + + E L +L + A PP PPA +E++
Sbjct: 260 MRKMSQEVCSLKKEKKHDKYRVETLERSLSKLKNQMAEPL-PPEPPAVP-----SEAELQ 313
Query: 559 KVQRAAAGVGGSLRAQVE-----RLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRY 613
+++ V G+L+AQVE L E Q+ER R +++R + ERL AE + +
Sbjct: 314 HLRKELERVAGALQAQVEYNQRISLLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKE 373
Query: 614 QKQLQHNYIQMYRRNRQLEQEL 635
+ +Q+ ++ ++L+++L
Sbjct: 374 LNNENKSVLQLEQQVKELQEKL 395
Score = 36.2 bits (82), Expect = 0.10
Identities = 47/192 (24%), Positives = 85/192 (44%), Gaps = 48/192 (25%)
Query: 329 LEGKLRDR---EAELQQLRDSLDENEATMCQAYE----ERQRHWQREREALREDCAAQAQ 381
LE +R++ +A+L QL++SL E + + E ER R QR R+ +E C+ + +
Sbjct: 214 LEQSMREQALLKAQLTQLKESLKEVQLERDEYAEHLKGERARWQQRMRKMSQEVCSLKKE 273
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDF----------AQLLQEREQLERRCATLE----- 426
+ ++ L+ L + K Q+ + A+L R++LER L+
Sbjct: 274 KKHDKYRVETLER-SLSKLKNQMAEPLPPEPPAVPSEAELQHLRKELERVAGALQAQVEY 332
Query: 427 ---------------REQRELGPRLEETKWEVCQ----------KSGEISLLKQQLKESQ 461
REQ+E P EE ++ + ++ + L+QQ+KE Q
Sbjct: 333 NQRISLLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQ 392
Query: 462 AELVQKGSELVA 473
+L ++ + LVA
Sbjct: 393 EKLGKRLAHLVA 404
Score = 32.7 bits (73), Expect = 1.1
Identities = 42/205 (20%), Positives = 85/205 (41%), Gaps = 12/205 (5%)
Query: 446 KSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELE 505
+S ++S LK +K + + Q +L + A E + R E + + L +
Sbjct: 93 RSVKVSQLKNTIKSLKQQKKQVVHQLEEEKKANNEKQKAERELEVQIQRLNIQKGKLNTD 152
Query: 506 LEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAE--SDEAKVQ-- 561
L + L+ +E++ L + Q + G E + TA AE S +K +
Sbjct: 153 LYHTKRSLRYFEEESKDLAVRL-QHSLQRKGELERALSAVTATQKKKAERFSSRSKARTE 211
Query: 562 ---RAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAE----KEQVIRYQ 614
+ L+AQ+ +L+ L+ + +E + +GER WQ ++V +
Sbjct: 212 WKLEQSMREQALLKAQLTQLKESLKEVQLERDEYAEHLKGERARWQQRMRKMSQEVCSLK 271
Query: 615 KQLQHNYIQMYRRNRQLEQELQQLS 639
K+ +H+ ++ R L + Q++
Sbjct: 272 KEKKHDKYRVETLERSLSKLKNQMA 296
>gi|21735548 centrosomal protein 2 [Homo sapiens]
Length = 2442
Score = 70.9 bits (172), Expect = 4e-12
Identities = 90/363 (24%), Positives = 153/363 (42%), Gaps = 49/363 (13%)
Query: 339 ELQQLRDSLDENEATMCQAYEERQRHW-QRERE--ALREDCAAQAQRAQRAQQLLQLQVF 395
ELQ+L+D L++ + + E QRE+E L++ ++ + +Q LQ Q+
Sbjct: 1747 ELQELKDQLEQQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLD 1806
Query: 396 QLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQ 455
+ Q+ Q + L QE++Q + + ++ + L LE+ + ++ GE+ K+
Sbjct: 1807 EAQRALAQRDQELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHKE 1866
Query: 456 QLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQE------------------ 497
Q + + EL +G + AL L + RA R E LQ+
Sbjct: 1867 QARRLEEELAVEGRRVQALEEVLGDLRAESREQEKALLALQQQCAEQAQEHEVETRALQD 1926
Query: 498 -------AARARELELEACSQELQ--RHRQE-----AEQLREKAGQLDAEAAGLREPPVP 543
+ R+ ELEA E Q RH++E AE L+E G+ A G + +
Sbjct: 1927 SWLQAQAVLKERDQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLE 1986
Query: 544 PATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRV---ELQRERRRGEEQRDSFE--- 597
A L E+ A +Q + R E LR+ E+Q + R +E +
Sbjct: 1987 QAELSRSL--EASTATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQAL 2044
Query: 598 ---GERLAWQAEKEQVIR--YQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGL 652
E L Q E+EQ++ +++Q N IQ + Q +E + L REL L L
Sbjct: 2045 AQRDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVREL-QLTL 2103
Query: 653 AEQ 655
A++
Sbjct: 2104 AQK 2106
Score = 67.8 bits (164), Expect = 3e-11
Identities = 98/371 (26%), Positives = 162/371 (43%), Gaps = 40/371 (10%)
Query: 330 EGK-LRDREAELQQLRDSLDENEATM---CQAYEERQRHWQREREALREDCAAQAQRAQR 385
EGK LR R +L RD+L + + + + Q+ RE LR+ Q A R
Sbjct: 429 EGKALRQRLQKLTGERDTLAGQTVDLQGEVDSLSKERELLQKAREELRQQLEVLEQEAWR 488
Query: 386 AQQL---LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
+++ LQLQ Q +K + Q++ ++ERE+L+ LE +Q E L +
Sbjct: 489 LRRVNVELQLQGDSAQGQKEEQQEELHLAVRERERLQEMLMGLEAKQSESLSELITLREA 548
Query: 443 VCQKSGEISLLKQQLKESQAELV---QKGSELVALRVALREARATLRVSEGRARGLQEA- 498
+ E LL+Q+ E A L Q +EL + L+ A LR + + L EA
Sbjct: 549 LESSHLEGELLRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAAAVKLSALNEAL 608
Query: 499 ------ARARELELEACSQELQRHRQEAEQLREKAGQLD-AEAAGLREPPVPPATADPFL 551
+ L+LE +Q + + AEQ R A Q+D AEA RE A +
Sbjct: 609 ALDKVGLNQQLLQLEEENQSVCSRMEAAEQAR-NALQVDLAEAEKRRE-----ALWEKNT 662
Query: 552 LAESDEAKVQRAAAGVGGSLR-AQVERLRVELQRERRRGEEQRDSFEGERLAWQA----- 605
E+ K + A A + LR Q E+ ++ + R +++ + + E+L +A
Sbjct: 663 HLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEE 722
Query: 606 -------EKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPC 658
EKE ++R + L+ + R + L ++LQ LS A+EL + L E
Sbjct: 723 VLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLS---SAKELLESSLFEAQQQ 779
Query: 659 ICLEEITATEI 669
+ E+T ++
Sbjct: 780 NSVIEVTKGQL 790
Score = 61.6 bits (148), Expect = 2e-09
Identities = 88/359 (24%), Positives = 160/359 (44%), Gaps = 47/359 (13%)
Query: 328 VLEGKLRDREAELQ----QLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRA 383
+L+ +L++ + EL+ Q RD L + +++ Q++ E L+ AQ
Sbjct: 968 ILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKM-DLQKQVEDLKSQLVAQDDSQ 1026
Query: 384 QRAQQLLQLQVFQLQQEKR---QLQDDFAQL---LQEREQ----LERRCATLEREQRELG 433
+ +Q +Q ++ + Q+ R +L+ + A L L E+EQ L+ + ++E L
Sbjct: 1027 RLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALR 1086
Query: 434 PRLEETKWEVCQKSGEISLLKQQLKESQAELV----QKGSELVALRVALREARATLRVSE 489
++E + E + S ++ LL+Q++KE +A+ + Q EL A + ++ RA+L E
Sbjct: 1087 QDMQEAQGEQKELSAQMELLRQEVKEKEADFLAQEAQLLEELEASHITEQQLRASLWAQE 1146
Query: 490 GRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADP 549
+A LQ R+ E +LEA + E Q Q Q QL + + L++ + P
Sbjct: 1147 AKAAQLQLRLRSTESQLEALAAEQQPGNQAQAQ-----AQLASLYSALQQALGSVCESRP 1201
Query: 550 FLLAESDEAKV-------QRAAAGV-----------GGSLRAQVERLRVELQRERRRGEE 591
L D A Q A + ++ + + +L +L + ++ +
Sbjct: 1202 ELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASALHKLHQDLWKTQQTRDV 1261
Query: 592 QRDSFE--GERLA-WQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEAREL 647
RD + ERL +AEK QV + LQ Q + + + E +Q SLE E EL
Sbjct: 1262 LRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQ--NQEEKSKWEGKQNSLESELMEL 1318
Score = 60.5 bits (145), Expect = 5e-09
Identities = 77/349 (22%), Positives = 157/349 (44%), Gaps = 52/349 (14%)
Query: 334 RDREAELQQL-------RDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRA 386
++R+A +QL + +L++ +A + + + W++ER +++ A + +R
Sbjct: 824 QERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLERE 883
Query: 387 QQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATL----EREQRELGPRLEETKWE 442
+ L++++ + Q E +Q AQ +ER Q E + E+E+ L L +T+ E
Sbjct: 884 KMELEMRLKEQQTEMEAIQ---AQREEERTQAESALCQMQLETEKERVSLLETLLQTQKE 940
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ S ++ L+Q +K + +++ L+ L+EA+ R L+EAAR
Sbjct: 941 LADASQQLERLRQDMK---VQKLKEQETTGILQTQLQEAQ----------RELKEAARQH 987
Query: 503 ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQR 562
+L A +E Q+ L+++ L ++ L+A+ D ++
Sbjct: 988 RDDLAALQEESSSLLQDKMDLQKQVEDLKSQ-----------------LVAQDDSQRL-- 1028
Query: 563 AAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQK--QLQHN 620
V LR E R++ + ER + E E+ ++ IR Q+ L+ +
Sbjct: 1029 VEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQEADSIRQQELSALRQD 1088
Query: 621 YIQMYRRNRQLEQELQQLSLELEARELADLGLAEQAPCICLEEITATEI 669
+ ++L +++ L E++ +E AD LA++A LEE+ A+ I
Sbjct: 1089 MQEAQGEQKELSAQMELLRQEVKEKE-ADF-LAQEAQ--LLEELEASHI 1133
Score = 59.7 bits (143), Expect = 8e-09
Identities = 95/384 (24%), Positives = 159/384 (41%), Gaps = 68/384 (17%)
Query: 326 HCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQR 385
H L+GK E +L SL+ + AT+ + + Q H ++ EALR Q Q
Sbjct: 1974 HAALQGK-EQHLLEQAELSRSLEASTATLQASLDACQAHSRQLEEALR----IQEGEIQD 2028
Query: 386 AQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQL------ERRCATLEREQRELGPRLEET 439
Q V QLQQ Q +D+ + QEREQL +R + +E++ LG EE
Sbjct: 2029 QDLRYQEDVQQLQQALAQ-RDEELRHQQEREQLLEKSLAQRVQENMIQEKQNLGQEREEE 2087
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAA 499
EI L Q ++E Q L QK E++ LR + + ++E
Sbjct: 2088 ---------EIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHSHKTSPMEE-- 2136
Query: 500 RARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAK 559
+ L+L++ LQR E E+L+ Q +A RE A + ++ +
Sbjct: 2137 --QSLKLDSLEPRLQR---ELERLQAALRQTEAREIEWREKAQDLALS--LAQTKASVSS 2189
Query: 560 VQRAAAGVGGSLR---AQVERLRVELQRERRRGEEQRDSFEG------------------ 598
+Q A + S+ ++ +RL+ EL+ RR E++R G
Sbjct: 2190 LQEVAMFLQASVLERDSEQQRLQDELELTRRALEKERLHSPGATSTAELGSRGEQGVQLG 2249
Query: 599 --------------ERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEA 644
E+ +W+ E + + +L+ + ++ R N QL L+Q +E E
Sbjct: 2250 EVSGVEAEPSPDGMEKQSWRQRLEHLQQAVARLEIDRSRLQRHNVQLRSTLEQ--VERER 2307
Query: 645 RELADLGL-AEQAPCICLEEITAT 667
R+L + A QA + + + TA+
Sbjct: 2308 RKLKREAMRAAQAGSLEISKATAS 2331
Score = 58.2 bits (139), Expect = 2e-08
Identities = 82/345 (23%), Positives = 146/345 (42%), Gaps = 41/345 (11%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEE------RQRHWQREREALREDCAAQAQR 382
LE +L D EAE Q+ L + + + Q EE +Q + E L E A+ R
Sbjct: 1269 LEERLTDTEAEKSQVHTELQDLQRQLSQNQEEKSKWEGKQNSLESELMELHETMASLQSR 1328
Query: 383 AQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLE----------RRCATLEREQREL 432
+RA +LQ + Q E+ LQ L + E L+ LE + R
Sbjct: 1329 LRRA----ELQRMEAQGERELLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTA 1384
Query: 433 GPRLEETKWEVCQKSGEISLLKQQ--LKESQAELVQKGSELVALRVALREARA-TLRVSE 489
L+ EV + L++Q LK +Q + +Q+ L+ +A RE TLR
Sbjct: 1385 RSALKLKNEEVESERERAQALQEQGELKVAQGKALQENLALLTQTLAEREEEVETLR--- 1441
Query: 490 GRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADP 549
G+ + L++ ++ LE S +L++ QE + +E+ +L+ + L P+ +
Sbjct: 1442 GQIQELEKQREMQKAALELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPMAVQEREQ 1501
Query: 550 FLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEG--------ERL 601
L + ++ R + R +E +EL+++ + E QR + E L
Sbjct: 1502 KLTVQREQI---RELEKDRETQRNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECL 1558
Query: 602 AWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQ-ELQQLSLELEAR 645
A + E+ ++ + Q I+ R+ ++ L L+L+LE R
Sbjct: 1559 ALELEEN---HHKMECQQKLIKELEGQRETQRVALTHLTLDLEER 1600
Score = 57.8 bits (138), Expect = 3e-08
Identities = 88/377 (23%), Positives = 162/377 (42%), Gaps = 58/377 (15%)
Query: 324 LLHCVLEGKLRDREAELQ--QLRDSLDENEATMCQAYEERQRHWQRE-REALREDCAAQA 380
L H +LE + +D+ E Q Q++D + C A E + H + E ++ L ++ Q
Sbjct: 1524 LEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELEGQR 1583
Query: 381 QRAQRAQQLLQLQVFQLQQE------------------KRQLQDDFAQLLQEREQLERR- 421
+ + A L L + + QE R+LQ+ ++ +REQ+E
Sbjct: 1584 ETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQ 1643
Query: 422 ------CATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALR 475
LER +EL + E + Q++ + +L++ L++ + L ++G EL R
Sbjct: 1644 RQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQR 1703
Query: 476 VALR----EARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLD 531
++ E + + G ++ R +E E+E C QE H E ++L++ QL+
Sbjct: 1704 QLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVE-CQQE---HIHELQELKD---QLE 1756
Query: 532 AEAAGL-------------REPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERL 578
+ GL RE + E E K Q + + + RA +R
Sbjct: 1757 QQLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRD 1816
Query: 579 R--VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRN-RQLEQEL 635
+ LQ+E+++ + Q + + + A Q EQ K+ +H +Q ++ R+LE+EL
Sbjct: 1817 QELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKE-RHGELQDHKEQARRLEEEL 1875
Query: 636 QQLSLELEARE--LADL 650
++A E L DL
Sbjct: 1876 AVEGRRVQALEEVLGDL 1892
Score = 57.0 bits (136), Expect = 6e-08
Identities = 79/355 (22%), Positives = 153/355 (43%), Gaps = 41/355 (11%)
Query: 328 VLEGKLRDREAELQQLRDSLDENEATMCQA--YEERQRHWQREREALREDCAAQAQRAQR 385
+L+ + A+++ L+ ++ E A A EE R + + E+ ++ +RAQ
Sbjct: 1345 LLQAAKENLTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQA 1404
Query: 386 AQQLLQLQVFQ---LQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWE 442
Q+ +L+V Q LQ+ L A+ +E E L + LE+++ LE +
Sbjct: 1405 LQEQGELKVAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLD 1464
Query: 443 VCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR 502
+ +++ E+ L ++Q++ EL + S L L +A++E L V + R L++ +
Sbjct: 1465 LKKRNQEVDLQQEQIQ----ELEKCRSVLEHLPMAVQEREQKLTVQREQIRELEKDRETQ 1520
Query: 503 E-------LELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAES 555
LELE Q ++ R + + L+++ L+ A L E +
Sbjct: 1521 RNVLEHQLLELEKKDQMIESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKELE 1580
Query: 556 DEAKVQRAA--------AGVGGSLRAQVER----------LRVELQRERRRGEEQRDSFE 597
+ + QR A L+AQ + L ELQ + + QR+ E
Sbjct: 1581 GQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIE 1640
Query: 598 -----GERLAWQAEK--EQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEAR 645
E L E+ ++++ ++++Q Q R+ + LE++L+Q+ L L R
Sbjct: 1641 ELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRER 1695
Score = 53.5 bits (127), Expect = 6e-07
Identities = 93/369 (25%), Positives = 149/369 (40%), Gaps = 56/369 (15%)
Query: 322 EALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALRE--DCAAQ 379
EAL LEG+L LR E A + +A + E E D A
Sbjct: 547 EALESSHLEGEL---------LRQEQTEVTAALARAEQSIAELSSSENTLKTEVADLRAA 597
Query: 380 AQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEET 439
A + + L L L Q+ QL+++ + E E+ L+ + E R E
Sbjct: 598 AVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQVDLAEAEKR-REA 656
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAA 499
WE + + L+ QL++++ + G+EL A ++E + ++ +R QEAA
Sbjct: 657 LWE------KNTHLEAQLQKAE----EAGAELQADLRDIQEEKEEIQKKLSESRHQQEAA 706
Query: 500 --RARELELEACSQE--LQRHRQEAEQL-REKAG------QLDAEAAGLREPPVPPATAD 548
+ +L EA QE L R QE E L REKA ++ + L E ++A
Sbjct: 707 TTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAK 766
Query: 549 PFLLAESDEAKVQRAAAGV-GGSLRAQVER--------------LRVELQRERRRGEEQR 593
L + EA+ Q + V G L Q++ L++EL ER + E++R
Sbjct: 767 ELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQER 826
Query: 594 DSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQL-------SLELEARE 646
D+ + + E + + QK + R + E+ Q SLE E E
Sbjct: 827 DAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREKWEKERSWHQQELAKALESLEREKME 886
Query: 647 LADLGLAEQ 655
L ++ L EQ
Sbjct: 887 L-EMRLKEQ 894
Score = 51.2 bits (121), Expect = 3e-06
Identities = 82/330 (24%), Positives = 123/330 (37%), Gaps = 57/330 (17%)
Query: 367 REREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLE 426
R R+A+ +D Q Q A LLQ Q Q ++E + L+ +L ER+ L + L+
Sbjct: 397 RRRQAV-QDLRQQLAGCQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQ 455
Query: 427 RE------QRELGPR-----------LEETKWEVCQKSGEISL----LKQQLKESQAELV 465
E +REL + LE+ W + + + E+ L + Q +E Q EL
Sbjct: 456 GEVDSLSKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELH 515
Query: 466 QKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQE-------LQRHRQ 518
E L+ L A S L+EA + LE E QE L R Q
Sbjct: 516 LAVRERERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQ 575
Query: 519 EAEQLREKAGQLDAEAAGLREPPVPPATADPFL-------------LAESDEAKVQRAAA 565
+L L E A LR V + + L L E +++ R A
Sbjct: 576 SIAELSSSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEA 635
Query: 566 GVGGSLRAQVERLRVELQRER------------RRGEEQRDSFEGERLAWQAEKEQVIRY 613
QV+ E +RE ++ EE + + Q EKE++
Sbjct: 636 AEQARNALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEI--- 692
Query: 614 QKQLQHNYIQMYRRNRQLEQELQQLSLELE 643
QK+L + Q QLEQ Q+ + E
Sbjct: 693 QKKLSESRHQQEAATTQLEQLHQEAKRQEE 722
Score = 41.6 bits (96), Expect = 0.002
Identities = 74/334 (22%), Positives = 127/334 (38%), Gaps = 50/334 (14%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
LE + +R EL QL+ D +A + E +A ++Q+ +
Sbjct: 256 LEKEAHERSQELIQLKSQGDLEKAELQDRVTE---------------LSALLTQSQKQNE 300
Query: 389 LLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCA----TLEREQRELGPRLEETKWEVC 444
+ + L++ L+ + +L++ L R +L++ +++ + E +
Sbjct: 301 DYEKMIKALRETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA 360
Query: 445 QKSG-EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARAR- 502
Q SG E SL SQ + L +R L R ++ + G QEA
Sbjct: 361 QGSGHENSLELDSSIFSQFDYQDADKALTLVRSVLTRRRQAVQDLRQQLAGCQEAVNLLQ 420
Query: 503 ------ELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
E E +A Q LQ+ E + L + L E L + + LL ++
Sbjct: 421 QQHDQWEEEGKALRQRLQKLTGERDTLAGQTVDLQGEVDSL--------SKERELLQKAR 472
Query: 557 EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEE---QRDSFEGERLAWQAEKEQVIRY 613
E LR Q+E L E R RR E Q DS +G++ Q E +R
Sbjct: 473 E------------ELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRE 520
Query: 614 QKQLQHNYIQMYRRNRQLEQELQQLSLELEAREL 647
+++LQ + + + + EL L LE+ L
Sbjct: 521 RERLQEMLMGLEAKQSESLSELITLREALESSHL 554
Score = 40.4 bits (93), Expect = 0.005
Identities = 78/337 (23%), Positives = 132/337 (39%), Gaps = 55/337 (16%)
Query: 341 QQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQE 400
QQLR SL EA Q + R R + + EAL AA+ Q +AQ QL
Sbjct: 1136 QQLRASLWAQEAKAAQL-QLRLRSTESQLEAL----AAEQQPGNQAQAQAQLASLY---- 1186
Query: 401 KRQLQDDFAQLLQEREQLERRCAT------LEREQR------ELGP-------------- 434
LQ + + R +L + LE +Q + GP
Sbjct: 1187 -SALQQALGSVCESRPELSGGGDSAPSVWGLEPDQNGARSLFKRGPLLTALSAEAVASAL 1245
Query: 435 -RLEETKWEVCQKSG----EISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSE 489
+L + W+ Q ++ L+++L +++AE Q +EL L+ L + + +
Sbjct: 1246 HKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQRQLSQNQE----EK 1301
Query: 490 GRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADP 549
+ G Q + + +EL LQ + AE R +A E L+
Sbjct: 1302 SKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEA---QGERELLQAAKENLTAQVE 1358
Query: 550 FLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQ 609
L A EA+ Q +AAG+ L + R L+ + E +R+ + A Q + E
Sbjct: 1359 HLQAAVVEARAQASAAGI---LEEDLRTARSALKLKNEEVESERERAQ----ALQEQGEL 1411
Query: 610 VIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARE 646
+ K LQ N + + + E+E++ L +++ E
Sbjct: 1412 KVAQGKALQENLALLTQTLAEREEEVETLRGQIQELE 1448
Score = 34.7 bits (78), Expect = 0.29
Identities = 61/281 (21%), Positives = 105/281 (37%), Gaps = 20/281 (7%)
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQ-----------R 430
+ Q Q +L+ QV LQQ+ + Q + L+ ++ ++R ATL R+ +
Sbjct: 12 KPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQ 71
Query: 431 ELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEG 490
EL RLE T + Q+ + + L E L ++ +L + R + ++
Sbjct: 72 ELEKRLEATGGPIPQRWENVE--EPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADV 129
Query: 491 RARGLQEAARARELELEACSQELQRHRQEAEQLRE-KAGQLDAEAAGLREPPVPPATADP 549
+ L+E ++ EL R + + +E G L E L T
Sbjct: 130 VNKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGYLKGEHGRLLSLWREVVTFRR 189
Query: 550 FLL-----AESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQ 604
L + D +++ + GSL RL V Q G + D E +L
Sbjct: 190 HFLEMKSATDRDLMELKAEHVRLSGSLLTCCLRLTVGAQSREPNGSGRMDGREPAQLLLL 249
Query: 605 AEKEQVIRYQKQLQHNYIQMYRRNRQLEQ-ELQQLSLELEA 644
K Q + + + + + LE+ ELQ EL A
Sbjct: 250 LAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSA 290
Score = 30.0 bits (66), Expect = 7.2
Identities = 32/140 (22%), Positives = 64/140 (45%), Gaps = 8/140 (5%)
Query: 337 EAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQL---LQLQ 393
E ++ L+ + EN+A + + Q QR+ +R+ A Q Q+L L+
Sbjct: 21 EEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEAT 80
Query: 394 VFQLQQEKRQLQD-DFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKS--GEI 450
+ Q +++ + +LL E+ ++RC +L +L RL K +V K+ ++
Sbjct: 81 GGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQL--RLHMEKADVVNKALREDV 138
Query: 451 SLLKQQLKESQAELVQKGSE 470
L ++ EL++K S+
Sbjct: 139 EKLTVDWSRARDELMRKESQ 158
>gi|239745087 PREDICTED: similar to Golgin subfamily A member 8-like
protein 1 isoform 1 [Homo sapiens]
Length = 547
Score = 70.9 bits (172), Expect = 4e-12
Identities = 93/402 (23%), Positives = 170/402 (42%), Gaps = 48/402 (11%)
Query: 273 SGRSSSSKSTGSLGGRVAGGLLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGK 332
+G + K+ GS+ SG SP S+ G P + C
Sbjct: 42 AGAKRNRKTNGSIHETAT-----SGGCHSPGDSATGIHGESPTSSATLKDLESPCQELAV 96
Query: 333 LRD-REAELQQLRD---SLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQ 388
+ D R ++ QL++ SL + + + EE ++ +++A RE Q QR +
Sbjct: 97 VPDSRSVKVSQLKNTIKSLKQQKKQVVHQLEEEKKANNEKQKAERE-LEVQIQRLNIQKG 155
Query: 389 LLQLQVFQLQQEKRQLQDDFAQL-------LQEREQLERRCATLEREQRELGPRL----- 436
L ++ ++ R +++ L LQ + +LER + + Q++ R
Sbjct: 156 KLNTDLYHTKRSLRYFEEESKDLAVRLQHSLQRKGELERALSAVTATQKKKAERQFSSRS 215
Query: 437 -EETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGL 495
T+W++ Q E +LLK QL + + L + V L + RAR
Sbjct: 216 KARTEWKLEQSMREQALLKAQLTQLKESLKE---------VQLERDEYAEHLKGERARWQ 266
Query: 496 QEAARARELELEACS--QELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLA 553
Q R R++ E CS +E + + E L +L + A PP PPA +
Sbjct: 267 Q---RMRKMSQEVCSLKKEKKHDKYRVETLERSLSKLKNQMAEPL-PPEPPAVP-----S 317
Query: 554 ESDEAKVQRAAAGVGGSLRAQVE-----RLRVELQRERRRGEEQRDSFEGERLAWQAEKE 608
E++ +++ V G+L+AQVE L E Q+ER R +++R + ERL AE +
Sbjct: 318 EAELQHLRKELERVAGALQAQVEYNQRISLLNEGQKERLREQQERLPEQEERLQQLAEPQ 377
Query: 609 QVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELADL 650
+ + +Q+ ++ ++L+++L + LE +++ L
Sbjct: 378 NSFKELNNENKSVLQLEQQVKELQEKLGKERLEAASQQKQQL 419
Score = 43.5 bits (101), Expect = 6e-04
Identities = 52/213 (24%), Positives = 99/213 (46%), Gaps = 37/213 (17%)
Query: 381 QRAQRAQQLLQLQVFQLQQEKRQLQ---DDFAQLLQ-EREQLERRCATLEREQRELGPRL 436
+++ R Q LL+ Q+ QL++ +++Q D++A+ L+ ER + ++R + +E L
Sbjct: 224 EQSMREQALLKAQLTQLKESLKEVQLERDEYAEHLKGERARWQQRMRKMSQEVCSLKKEK 283
Query: 437 EETKWEVCQKSGEISLLKQQLKE----------SQAELVQKGSELVAL------------ 474
+ K+ V +S LK Q+ E S+AEL EL +
Sbjct: 284 KHDKYRVETLERSLSKLKNQMAEPLPPEPPAVPSEAELQHLRKELERVAGALQAQVEYNQ 343
Query: 475 RVALREARATLRVSEGRARGLQEAARAREL--------ELEACSQELQRHRQEAEQLREK 526
R++L R+ E + R ++ R ++L EL ++ + + Q+ ++L+EK
Sbjct: 344 RISLLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQEK 403
Query: 527 AGQLDAEAAGLREPPVPPATADPFLLAESDEAK 559
G+ EAA ++ + TA L+A EA+
Sbjct: 404 LGKERLEAASQQKQQL---TAQLSLMALPGEAQ 433
Score = 39.7 bits (91), Expect = 0.009
Identities = 58/239 (24%), Positives = 102/239 (42%), Gaps = 50/239 (20%)
Query: 329 LEGKLRDR---EAELQQLRDSLDENEATMCQAYE----ERQRHWQREREALREDCAAQAQ 381
LE +R++ +A+L QL++SL E + + E ER R QR R+ +E C+ + +
Sbjct: 223 LEQSMREQALLKAQLTQLKESLKEVQLERDEYAEHLKGERARWQQRMRKMSQEVCSLKKE 282
Query: 382 RAQRAQQLLQLQVFQLQQEKRQLQDDF----------AQLLQEREQLERRCATLE----- 426
+ ++ L+ L + K Q+ + A+L R++LER L+
Sbjct: 283 KKHDKYRVETLER-SLSKLKNQMAEPLPPEPPAVPSEAELQHLRKELERVAGALQAQVEY 341
Query: 427 ---------------REQRELGPRLEETKWEVCQ----------KSGEISLLKQQLKESQ 461
REQ+E P EE ++ + ++ + L+QQ+KE Q
Sbjct: 342 NQRISLLNEGQKERLREQQERLPEQEERLQQLAEPQNSFKELNNENKSVLQLEQQVKELQ 401
Query: 462 AELVQKGSELVALRVALREARATLRVSEGRARG--LQEAARARELELEACSQELQRHRQ 518
+L ++ E + + A+ +L G A+G EAA A + A S HR+
Sbjct: 402 EKLGKERLEAASQQKQQLTAQLSLMALPGEAQGGDEDEAAGAAADGIAAYSNYNNGHRK 460
>gi|31982906 cingulin-like 1 [Homo sapiens]
Length = 1302
Score = 70.5 bits (171), Expect = 5e-12
Identities = 88/340 (25%), Positives = 148/340 (43%), Gaps = 61/340 (17%)
Query: 330 EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDC----------AAQ 379
E LR RE EL L+ +L E ++ Q ++ + + E +ALRE A++
Sbjct: 750 EDLLRKRERELTALKGALKEEVSSHDQEMDKLKEQYDAELQALRESVEEATKNVEVLASR 809
Query: 380 AQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEET 439
+ +++ Q +++V LQ+E +LQ E+LERR A L+R+ +L
Sbjct: 810 SNTSEQDQAGTEMRVKLLQEENEKLQG-------RSEELERRVAQLQRQIEDL------- 855
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAA 499
G+ + K+ LK+ + E+ Q LV R +EA + A
Sbjct: 856 -------KGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVS--------------AR 894
Query: 500 RARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAK 559
RA E ELEA L + QE +QL EK + + LR + + L ++ E K
Sbjct: 895 RALENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLK-NEMENERWHLGKTIE-K 952
Query: 560 VQRAAAGVGGSLRAQVERLRVELQ--RERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQ- 616
+Q+ A + + R L+ +L +E+ R E + + +AEK ++ + Q
Sbjct: 953 LQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQD 1012
Query: 617 ---LQHNYIQMYRR--------NRQLEQELQQLSLELEAR 645
L ++ Y+R + LEQ L+ L ELEA+
Sbjct: 1013 EMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAK 1052
Score = 62.0 bits (149), Expect = 2e-09
Identities = 90/367 (24%), Positives = 159/367 (43%), Gaps = 72/367 (19%)
Query: 332 KLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREAL-----REDCAAQAQRA-QR 385
+L R A+LQ+ + L +EA + ++ + ++ EAL E A A+RA +
Sbjct: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALEN 899
Query: 386 AQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQ 445
+ Q + Q QE++QL + + +++EQL R +E E+ LG +E+ + E+
Sbjct: 900 ELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNEMENERWHLGKTIEKLQKEMAD 959
Query: 446 -----KSGEISLLKQ----------QLKESQAELVQKGSELVALRVALREARATLRVSEG 490
++ + L Q +L E Q +L +K E R+ + + +R+ E
Sbjct: 960 IVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQDEMRLMEE 1019
Query: 491 RARGLQ----EAARAREL----------ELEACSQELQRHRQEAEQLREKAGQLDAEAAG 536
R Q EA R+L ELEA S + +Q+ +K QL+ E
Sbjct: 1020 ELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVSQLEMELEE 1079
Query: 537 LREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSF 596
R + LL+E ++ R+ R Q+E+LR EL +ER R
Sbjct: 1080 ERN--------NSDLLSE----RISRS--------REQMEQLRNELLQER----AARQDL 1115
Query: 597 EGERLAWQAE----KEQVIR----YQKQLQHNYIQMYRRNRQLEQELQQLSLELEARELA 648
E ++++ + + K ++I Y+ + +QM R +LE LE E R+ A
Sbjct: 1116 ECDKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDR-----LESEERDRA 1170
Query: 649 DLGLAEQ 655
+L L+ +
Sbjct: 1171 NLQLSNR 1177
Score = 55.8 bits (133), Expect = 1e-07
Identities = 93/413 (22%), Positives = 168/413 (40%), Gaps = 72/413 (17%)
Query: 293 LLGSGTRASPDSSSCGERSPPPPPPPPSDEALLHCVLEGKLR-----DREAELQQLRDSL 347
L T SPDS + ++ P S+ +L+G+ + E Q L + L
Sbjct: 506 LQNRATATSPDSGA--KKISVKTFPSASNTQATPDLLKGQQELTQQTNEETAKQILYNYL 563
Query: 348 DENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDD 407
E A + + + + L+ A AQ +A +V L ++K +L +
Sbjct: 564 KEGSTDNDDATKRKVNLVFEKIQTLKSRAAGSAQGNNQACNSTS-EVKDLLEQKSKLTIE 622
Query: 408 FAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQK 467
A+L ++ + + ++ E+ + LEE + + +K E S L+Q+L+ES+ EL +
Sbjct: 623 VAELQRQLQLEVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKN 682
Query: 468 GSELVALRVALREARATLR-----------------VSEGRARGL--------------- 495
EL +++ + + +R SE R +G
Sbjct: 683 LEELFQVKMEREQHQTEIRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDL 742
Query: 496 -------QEAARARELELE----ACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPP 544
++ R RE EL A +E+ H QE ++L+E Q DAE LRE V
Sbjct: 743 LIAKEEQEDLLRKRERELTALKGALKEEVSSHDQEMDKLKE---QYDAELQALRE-SVEE 798
Query: 545 ATADPFLLAESDEAKVQRAAAGVGGSLRAQV-----ERLR---VELQRERRRGEEQRDSF 596
AT + +LA Q A G +R ++ E+L+ EL+R + + Q +
Sbjct: 799 ATKNVEVLASRSNTSEQDQA---GTEMRVKLLQEENEKLQGRSEELERRVAQLQRQIEDL 855
Query: 597 EGERLAWQAEKEQVIRYQ---KQLQHNYIQMYRRNRQLEQELQQLSLELEARE 646
+G+ KE + +Y+ +QL+ + + ++ + L ELEA +
Sbjct: 856 KGDE---AKAKETLKKYEGEIRQLEEALVHARKEEKEAVSARRALENELEAAQ 905
Score = 39.3 bits (90), Expect = 0.012
Identities = 41/205 (20%), Positives = 92/205 (44%), Gaps = 21/205 (10%)
Query: 321 DEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYE--ERQRHWQREREALREDCAA 378
D + L +E K+ E EL++ R++ D + ++ E E+ R+ + A R+D
Sbjct: 1058 DRSRLVKQMEDKVSQLEMELEEERNNSDLLSERISRSREQMEQLRNELLQERAARQDLEC 1117
Query: 379 QAQRAQRAQQLLQLQVFQLQQEKR---------------QLQDDFAQLLQEREQLERRCA 423
+R + L+ ++ L+ R +L+D ++R L+
Sbjct: 1118 DKISLERQNKDLKSRIIHLEGSYRSSKEGLVVQMEARIAELEDRLESEERDRANLQLSNR 1177
Query: 424 TLEREQRELGPRLEETKWEVCQKSGEISL----LKQQLKESQAELVQKGSELVALRVALR 479
LER+ +EL ++++ + + ++SL +K+Q++E++ E+ + S L+ L
Sbjct: 1178 RLERKVKELVMQVDDEHLSLTDQKDQLSLRLKAMKRQVEEAEEEIDRLESSKKKLQRELE 1237
Query: 480 EARATLRVSEGRARGLQEAARAREL 504
E +G+ +++ R ++L
Sbjct: 1238 EQMDMNEHLQGQLNSMKKDLRLKKL 1262
>gi|157738667 FYVE and coiled-coil domain containing 1 [Homo
sapiens]
Length = 1478
Score = 70.1 bits (170), Expect = 6e-12
Identities = 77/325 (23%), Positives = 135/325 (41%), Gaps = 25/325 (7%)
Query: 329 LEGKLRDREAELQQLRDSLDENE---------ATMCQAYEERQRHWQREREALREDCAAQ 379
LE L+ EL+ RDSLD+ M Q + + +E + D A +
Sbjct: 340 LESMLQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQE 399
Query: 380 AQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEET 439
Q Q L+ + ++++ RQ QL++E + E A+LER +E+ P E
Sbjct: 400 MQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLVKEMAPLQE-- 457
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAA 499
E+ K E L ++L+E A EL LR ++ + + E R L
Sbjct: 458 --ELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQL 515
Query: 500 RARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAK 559
+ E +L SQ + ++ +QL + L + L PP P + E +EA
Sbjct: 516 QFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELP-VAGEKNEAL 574
Query: 560 VQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
V V SL+ + E +RG Q + ++ +++E++ + ++L+
Sbjct: 575 VP-----VNSSLQEAWGK-----PEEEQRG-LQEAQLDDTKVQEGSQEEELRQANRELEK 623
Query: 620 NYIQMYRRNRQLEQELQQLSLELEA 644
+ RN+ LE +LQ L + +A
Sbjct: 624 ELQNVVGRNQLLEGKLQALQADYQA 648
Score = 55.1 bits (131), Expect = 2e-07
Identities = 81/335 (24%), Positives = 142/335 (42%), Gaps = 36/335 (10%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQ---R 385
L+ +L + E QL L E A ++EE +RE++ +E+ Q + R
Sbjct: 455 LQEELSGKGQEADQLWRRLQELLAHT-SSWEEELAELRREKKQQQEEKELLEQEVRSLTR 513
Query: 386 AQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRL----EETKW 441
Q L+ Q+ Q+ Q L++ QL+Q+++ L ++ LER GP L E+ +
Sbjct: 514 QLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGMLERLAGPPGPELPVAGEKNEA 573
Query: 442 EVCQKS------GEISLLKQQLKESQAE--LVQKGSELVALRVALREARATLRVSEGRAR 493
V S G+ ++ L+E+Q + VQ+GS+ LR A RE L+ GR +
Sbjct: 574 LVPVNSSLQEAWGKPEEEQRGLQEAQLDDTKVQEGSQEEELRQANRELEKELQNVVGRNQ 633
Query: 494 GLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLA 553
L E +L+A + Q +Q ++ L+AE A +R L
Sbjct: 634 LL-------EGKLQALQADYQALQQRESAIQGSLASLEAEQASIRH------------LG 674
Query: 554 ESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRY 613
+ EA + A +++AQ+ LQ + ++ R+ E + +A ++
Sbjct: 675 DQMEASL-LAVRKAKEAMKAQMAEKEAILQSKEGECQQLREEVEQCQQLAEARHRELRAL 733
Query: 614 QKQLQHNYIQMYRRNRQLEQELQQLSLELEARELA 648
+ Q Q + + Q+ + EARELA
Sbjct: 734 ESQCQQQTQLIEVLTAEKGQQGVGPPTDNEARELA 768
Score = 48.5 bits (114), Expect = 2e-05
Identities = 73/341 (21%), Positives = 142/341 (41%), Gaps = 42/341 (12%)
Query: 335 DREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDCAAQAQRAQRAQQLLQLQ- 393
D ++ + ++ + + A Q E+ + +RER + E Q+ + ++ + LQL+
Sbjct: 380 DTASDTKGRQEPIPSDAAQEMQELGEKLQALERERTKVEEVNRQQSAQLEQLVKELQLKE 439
Query: 394 -----VFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSG 448
+ +L +E LQ++ + QE +QL RR L L E + E Q+
Sbjct: 440 DARASLERLVKEMAPLQEELSGKGQEADQLWRRLQELLAHTSSWEEELAELRREKKQQQE 499
Query: 449 EISLLKQQLK---------ESQ-AELVQKGSELVALRVALREARATLRVSEGRARGLQEA 498
E LL+Q+++ E+Q A++ Q S+L + L + + L G L+
Sbjct: 500 EKELLEQEVRSLTRQLQFLETQLAQVSQHVSDLEEQKKQLIQDKDHLSQQVGM---LERL 556
Query: 499 ARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEA 558
A EL ++ + L+E G+ + E GL+E A+ D+
Sbjct: 557 AGPPGPELPVAGEKNEALVPVNSSLQEAWGKPEEEQRGLQE-------------AQLDDT 603
Query: 559 KVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQ 618
KVQ GS ++ + EL++E + + EG+ A QA+ + + + + +Q
Sbjct: 604 KVQE------GSQEEELRQANRELEKELQNVVGRNQLLEGKLQALQADYQALQQRESAIQ 657
Query: 619 HNYIQMYRRNRQLEQELQQLSLEL----EARELADLGLAEQ 655
+ + + Q+ L +A+E +AE+
Sbjct: 658 GSLASLEAEQASIRHLGDQMEASLLAVRKAKEAMKAQMAEK 698
Score = 48.1 bits (113), Expect = 3e-05
Identities = 68/304 (22%), Positives = 118/304 (38%), Gaps = 36/304 (11%)
Query: 308 GERSPPPPPPPPSDEALLHCVL-EGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQ 366
G++ PP + E L + +L + E+Q+L+ + + +A M
Sbjct: 752 GQQGVGPPTDNEARELAAQLALSQAQLEVHQGEVQRLQAQVVDLQAKM------------ 799
Query: 367 REREALREDCAAQAQRAQRAQQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLE 426
R AL + Q+Q + A+ +L+ +QQ K Q + +QE Q R L+
Sbjct: 800 --RAALDDQDKVQSQLSM-AEAVLREHKTLVQQLKEQNEALNRAHVQELLQCSEREGALQ 856
Query: 427 REQ-----------RELGPRLEETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALR 475
E+ R L L + K + E + L++QL + + + G ++ AL
Sbjct: 857 EERADEAQQREEELRALQEELSQAKCSSEEAQLEHAELQEQLHRANTDTAELGIQVCALT 916
Query: 476 VALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAA 535
V L + + LQ+A A E E +++ +QE E L+EK A A
Sbjct: 917 VEKERVEEALACA---VQELQDAKEAASREREGLERQVAGLQQEKESLQEKLKAAKAAAG 973
Query: 536 GLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDS 595
L P AE +Q AA +L+ Q+ ++ Q + E+ S
Sbjct: 974 SL------PGLQAQLAQAEQRAQSLQEAAHQELNTLKFQLSAEIMDYQSRLKNAGEECKS 1027
Query: 596 FEGE 599
G+
Sbjct: 1028 LRGQ 1031
Score = 35.4 bits (80), Expect = 0.17
Identities = 63/320 (19%), Positives = 129/320 (40%), Gaps = 71/320 (22%)
Query: 390 LQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQ----RELGPRLEE------- 438
++L++ QL+ ++QL++ QL +E ++L R + + EQ RE G E
Sbjct: 235 MRLELDQLEVREKQLRERMQQLDRENQEL-RAAVSQQGEQLQTERERGRTAAEDNVRLTC 293
Query: 439 ------TKWEVCQKS---------------------------------GEISLLKQQLKE 459
+WEV Q + + L Q+L+
Sbjct: 294 LVAELQKQWEVTQATQNTVKELQTCLQGLELGAAEKEEDYHTALRRLESMLQPLAQELEA 353
Query: 460 SQAELVQKGSELVALR--VALREARA-TLRVSEGRARGLQEAARARELELEACSQELQRH 516
++ L +K L + +A+ + +A T ++GR + A EL Q L+R
Sbjct: 354 TRDSLDKKNQHLASFPGWLAMAQQKADTASDTKGRQEPIPSDAAQEMQELGEKLQALERE 413
Query: 517 RQEAEQL-REKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQV 575
R + E++ R+++ QL+ L+ A+ + + + A +Q +G G
Sbjct: 414 RTKVEEVNRQQSAQLEQLVKELQLKEDARASLERLV---KEMAPLQEELSGKGQEADQLW 470
Query: 576 ERLR-------------VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYI 622
RL+ EL+RE+++ +E+++ E E + + + + Q+ +
Sbjct: 471 RRLQELLAHTSSWEEELAELRREKKQQQEEKELLEQEVRSLTRQLQFLETQLAQVSQHVS 530
Query: 623 QMYRRNRQLEQELQQLSLEL 642
+ + +QL Q+ LS ++
Sbjct: 531 DLEEQKKQLIQDKDHLSQQV 550
Score = 33.1 bits (74), Expect = 0.85
Identities = 54/255 (21%), Positives = 105/255 (41%), Gaps = 33/255 (12%)
Query: 406 DDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQKSGEISLLKQQLKESQAELV 465
+ F ++ E +QLE R L ++L +E + V Q+ ++ +++ + + + V
Sbjct: 230 EGFDEMRLELDQLEVREKQLRERMQQLDRENQELRAAVSQQGEQLQTERERGRTAAEDNV 289
Query: 466 QKGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRH---RQEAEQ 522
+ L L L++ + ++ + LQ + LEL A +E H R+
Sbjct: 290 R----LTCLVAELQKQWEVTQATQNTVKELQTCLQG--LELGAAEKEEDYHTALRRLESM 343
Query: 523 LREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVEL 582
L+ A +L+A L + A+ +L +A G + E + +
Sbjct: 344 LQPLAQELEATRDSLDKKNQHLASFPGWLAMAQQKADTASDTKG-------RQEPIPSDA 396
Query: 583 QRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLEL 642
+E + E+ + E ER + E+V R Q + QLEQ +++L L+
Sbjct: 397 AQEMQELGEKLQALERER----TKVEEVNRQQ-------------SAQLEQLVKELQLKE 439
Query: 643 EARELADLGLAEQAP 657
+AR + + E AP
Sbjct: 440 DARASLERLVKEMAP 454
>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
Length = 2003
Score = 69.3 bits (168), Expect = 1e-11
Identities = 109/428 (25%), Positives = 166/428 (38%), Gaps = 106/428 (24%)
Query: 321 DEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQR------HWQRERE---- 370
+E L ++R EAE LR+ L+E A +A E Q W+R +E
Sbjct: 1351 EETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQTAQAQLSEWRRRQEEEAG 1410
Query: 371 ALREDCAAQAQRAQRAQQLLQL------QVFQLQQEKRQLQDDFAQLLQEREQLERRCAT 424
AL A+ + A+ A+ L Q V +L++ +R+LQ + + EQ + +T
Sbjct: 1411 ALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVST 1470
Query: 425 LEREQRELGPRLEETKWEVCQKSGE---------------ISLLK--QQLKESQAELVQK 467
LE++QR+ L E K V + E +SL + ++ +E++ EL ++
Sbjct: 1471 LEKKQRKFDQLLAEEKAAVLRAVEERERAEAEGREREARALSLTRALEEEQEAREELERQ 1530
Query: 468 GSELVALRVAL-----------REARATLRVSEGRARGLQ----------EAARARELEL 506
L A AL E RV+E A L+ AA +L L
Sbjct: 1531 NRALRAELEALLSSKDDVGKSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRL 1590
Query: 507 EACSQEL----------------QRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPF 550
E Q L +R RQ A+QLR+ + D E R+ A
Sbjct: 1591 EVTVQALKTQHERDLQGRDEAGEERRRQLAKQLRDAEVERDEE----RKQRTLAVAARKK 1646
Query: 551 LLAESDEAKVQRAAAGVG--------GSLRAQVERL----------RVELQRERRRGEEQ 592
L E +E K Q A+AG G ++AQ++ L R E+ + R E++
Sbjct: 1647 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1706
Query: 593 RDSFEGERLAWQAEKEQVIRYQKQLQHNYIQM--------------YRRNRQLEQELQQL 638
E E L Q E R ++Q Q + +M RQLE L QL
Sbjct: 1707 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL 1766
Query: 639 SLELEARE 646
ELE +
Sbjct: 1767 EEELEEEQ 1774
Score = 65.9 bits (159), Expect = 1e-10
Identities = 85/360 (23%), Positives = 149/360 (41%), Gaps = 60/360 (16%)
Query: 321 DEALLHCVLEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQREREALREDC---- 376
DE L LR+ +A L + ++ L+ +A E+++R E EALR +
Sbjct: 1126 DEGGARAQLLKSLREAQAALAEAQEDLESERVARTKA-EKQRRDLGEELEALRGELEDTL 1184
Query: 377 ----AAQAQRAQRAQQLLQLQ-------------VFQLQQEKRQLQDDFAQLLQEREQ-- 417
A Q R++R Q++ +L+ V +L+Q Q + A+ L++ +
Sbjct: 1185 DSTNAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGK 1244
Query: 418 --LERRCATLEREQRELGPRLEETKWEVCQKSGEISL--LKQQLKESQAEL-------VQ 466
E+ LE E EL R E + + ++ GE L+ QL+E Q +
Sbjct: 1245 GAWEKTRLALEAEVSEL--RAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAE 1302
Query: 467 KGSELVALRVALREARATLRVSEGRARGLQEAARARELELEACSQELQRHRQEAEQLREK 526
+L + L L +E + L + + E +L + LQ + L +
Sbjct: 1303 AAEKLQRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSR 1362
Query: 527 AGQLDAEAAGLREPPVPPATADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVELQRER 586
++AEAAGLRE + +E R AG +++ + +L R
Sbjct: 1363 VRAMEAEAAGLRE--------------QLEEEAAARERAG------RELQTAQAQLSEWR 1402
Query: 587 RRGEEQRDSFE-GERLAWQAEKEQVIRYQK--QLQHNYIQMYRRNRQLEQELQQLSLELE 643
RR EE+ + E GE +A +E Q+ + ++ R R+L+QEL +++LE
Sbjct: 1403 RRQEEEAGALEAGEEARRRAAREAEALTQRLAEKTETVDRLERGRRRLQQELDDATMDLE 1462
Score = 59.3 bits (142), Expect = 1e-08
Identities = 75/336 (22%), Positives = 141/336 (41%), Gaps = 47/336 (13%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQR--EREALREDCAAQAQRAQRA 386
LEG+L + +A++ +E + + + + W+ E RE+ +Q + +++
Sbjct: 1647 LEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKR 1706
Query: 387 QQLLQLQVFQLQQE-------KRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEET 439
+ L+ +V +LQ+E +RQ Q D ++ E A + E+R+L RL +
Sbjct: 1707 LKGLEAEVLRLQEELAASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQL 1766
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAA 499
+ E+ ++ LL + ++ ++ +EL A
Sbjct: 1767 EEELEEEQSNSELLNDRYRKLLLQVESLTTEL-------------------------SAE 1801
Query: 500 RARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAK 559
R+ + E+ Q+L+R Q++E G+L E AG R A LA+++E
Sbjct: 1802 RSFSAKAESGRQQLER------QIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQL 1855
Query: 560 VQRAAAGV--GGSLRAQVERLR---VELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQ 614
Q + G +R +RL+ ++++ ERR ++ RD E L + K Q+ +
Sbjct: 1856 EQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQLRDQLEKGNLRVKQLKRQLEEAE 1915
Query: 615 KQLQHNYIQMYRRNRQLEQELQQLSLELEARELADL 650
++ Q RR Q E E S E RE+ L
Sbjct: 1916 EEASR--AQAGRRRLQRELEDVTESAESMNREVTTL 1949
Score = 58.5 bits (140), Expect = 2e-08
Identities = 74/319 (23%), Positives = 133/319 (41%), Gaps = 18/319 (5%)
Query: 329 LEGKLRDREAELQQLRDSLDENEATMCQ------AYEERQRHWQREREALREDCAA-QAQ 381
LE L E Q+L+ EA M + E++ +ER+ L + A +Q
Sbjct: 980 LEAHLEAEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQ 1039
Query: 382 RAQRAQQLLQLQVFQLQQEKR--QLQDDFAQLLQEREQLERRCATLEREQRELGPRLEET 439
A+ +++ L +L+ E ++D + + R++LE+ L+ E EL ++ E
Sbjct: 1040 AAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVEQ 1099
Query: 440 KWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAA 499
+ + ++ +++L+ + A +G L +LREA+A L ++ + A
Sbjct: 1100 QQRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVAR 1159
Query: 500 RARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESDEAK 559
E + +EL+ R E E + E RE V EA
Sbjct: 1160 TKAEKQRRDLGEELEALRGELEDTLDST-NAQQELRSKREQEVTELKKTLEEETRIHEAA 1218
Query: 560 VQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQH 619
VQ G +L E+L + RRG + ++E RLA +AE ++ LQ
Sbjct: 1219 VQELRQRHGQALGELAEQL-----EQARRG---KGAWEKTRLALEAEVSELRAELSSLQT 1270
Query: 620 NYIQMYRRNRQLEQELQQL 638
+ +R R+LE +LQ++
Sbjct: 1271 ARQEGEQRRRRLELQLQEV 1289
Score = 57.4 bits (137), Expect = 4e-08
Identities = 89/369 (24%), Positives = 149/369 (40%), Gaps = 53/369 (14%)
Query: 333 LRDREAELQQLRDSLDENEATMC-QAYEERQR-----HWQREREALREDCAAQAQRAQRA 386
L D+ ++L + R L++ A QA EE ++ + + EA D + ++ ++
Sbjct: 1015 LEDQNSKLSKERKLLEDRLAEFSSQAAEEEEKVKSLNKLRLKYEATIADMEDRLRKEEKG 1074
Query: 387 QQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQK 446
+Q L+ +L E +LQ+ Q+++++++ E A L R++ EL L + E
Sbjct: 1075 RQELEKLKRRLDGESSELQE---QMVEQQQRAEELRAQLGRKEEELQAALARAEDE---- 1127
Query: 447 SGEISLLKQQLKESQAELVQKGSELVALRVALREA--------------RATLRVSEGRA 492
G + L + L+E+QA L + +L + RVA +A R L +
Sbjct: 1128 GGARAQLLKSLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDST 1187
Query: 493 RGLQEAARARELEL----EACSQELQRHRQEAEQLREKAGQLDAEAAG-LREPPVPPATA 547
QE RE E+ + +E + H ++LR++ GQ E A L +
Sbjct: 1188 NAQQELRSKREQEVTELKKTLEEETRIHEAAVQELRQRHGQALGELAEQLEQARRGKGAW 1247
Query: 548 DPFLLAESDEAKVQRA-------AAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGER 600
+ LA E RA A G R ++E E+Q GE R +
Sbjct: 1248 EKTRLALEAEVSELRAELSSLQTARQEGEQRRRRLELQLQEVQGRAGDGERARAEAAEKL 1307
Query: 601 LAWQAEKEQV-----------IRYQKQLQHNYIQMYRRNRQLEQELQ---QLSLELEARE 646
QAE E V IR K+L Q++ L++E + L + A E
Sbjct: 1308 QRAQAELENVSGALNEAESKTIRLSKELSSTEAQLHDAQELLQEETRAKLALGSRVRAME 1367
Query: 647 LADLGLAEQ 655
GL EQ
Sbjct: 1368 AEAAGLREQ 1376
Score = 55.5 bits (132), Expect = 2e-07
Identities = 78/333 (23%), Positives = 138/333 (41%), Gaps = 43/333 (12%)
Query: 331 GKLRDREAELQQLRDSLDENEATMCQAYEERQRHWQRER---------EALRED--CAAQ 379
G L R + +Q + S C AY + RHWQ R + R+D A+
Sbjct: 824 GYLARRAFQKRQQQQSALRVMQRNCAAYL-KLRHWQWWRLFTKVKPLLQVTRQDEVLQAR 882
Query: 380 AQRAQRAQQLLQL---QVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRL 436
AQ Q+ Q+L Q +V +LQ QL+++ A+L ++ CA E + L R
Sbjct: 883 AQELQKVQELQQQSAREVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAARK 942
Query: 437 EETKWEVCQKSGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQ 496
+E + V S L+ ++ E + Q +E L+ ++E A L EG + LQ
Sbjct: 943 QELELVV-------SELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLEAEEGARQKLQ 995
Query: 497 EAARARELELEACSQELQRHRQEAEQLREKAGQLDAEAAGLREPPVPPATADPFLLAESD 556
LE ++++ ++ L ++ +L E L + A+ A +
Sbjct: 996 -------LEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLED-----RLAEFSSQAAEE 1043
Query: 557 EAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERLAWQAE----KEQVIR 612
E KV+ LR + E +++ R+ E+ R E + E +EQ++
Sbjct: 1044 EEKVKSL-----NKLRLKYEATIADMEDRLRKEEKGRQELEKLKRRLDGESSELQEQMVE 1098
Query: 613 YQKQLQHNYIQMYRRNRQLEQELQQLSLELEAR 645
Q++ + Q+ R+ +L+ L + E AR
Sbjct: 1099 QQQRAEELRAQLGRKEEELQAALARAEDEGGAR 1131
Score = 50.8 bits (120), Expect = 4e-06
Identities = 77/352 (21%), Positives = 148/352 (42%), Gaps = 51/352 (14%)
Query: 328 VLEGKLRDREAELQQLRDSLDENE-ATMCQAYEERQRHWQREREALREDCAAQAQRAQRA 386
V E D A++ +L D L E A + + Q ER+ D A + +R Q A
Sbjct: 1561 VAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLA 1620
Query: 387 QQLLQLQVFQLQQEKRQLQDDFAQLLQEREQLERRCATLEREQRELGPRLEETKWEVCQK 446
+QL +V + ++ K++ + R++LE L+ + G EE
Sbjct: 1621 KQLRDAEVERDEERKQR-----TLAVAARKKLEGELEELKAQMASAGQGKEEAV------ 1669
Query: 447 SGEISLLKQQLKESQAELVQKGSELVALRVALREARATLRVSEGRARGLQEAARARELEL 506
+QL++ QA++ + E+ R + E + R SE R +GL+ + EL
Sbjct: 1670 --------KQLRKMQAQMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQEEL 1721
Query: 507 EACSQELQRHRQEAEQLREKA--GQLDAEA-----------AGLREPPVPPATADPFLLA 553
A + ++ +Q+ +++ ++ G L A G E + ++ LL
Sbjct: 1722 AASDRARRQAQQDRDEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLN 1781
Query: 554 E------------SDEAKVQRAAAGVGGSLRAQVERLRVELQRERRRGEEQRDSFEGERL 601
+ + E +R+ + S R Q+ER EL+ R GEE + ++
Sbjct: 1782 DRYRKLLLQVESLTTELSAERSFSAKAESGRQQLERQIQELR--GRLGEEDAGARARHKM 1839
Query: 602 AWQAEKEQVIRYQKQLQ---HNYIQMYRRNRQLEQELQQLSLEL-EARELAD 649
A + ++ + ++QL+ I + R+ E+ L+++ L++ E R +AD
Sbjct: 1840 TIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD 1891
Score = 38.5 bits (88), Expect = 0.020
Identities = 49/184 (26%), Positives = 78/184 (42%), Gaps = 45/184 (24%)
Query: 473 ALRVALREARATLRVSEG-------RARGLQEAARARELELEACSQELQRHRQEAEQLRE 525
ALRV R A L++ + + L + R E+ L+A +QELQ+ ++ +Q
Sbjct: 840 ALRVMQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQDEV-LQARAQELQKVQELQQQSAR 898
Query: 526 KAGQLDAEAAGLREPPVPPAT---ADPFLLAESDEAKVQRAAAGVGGSLRAQVERLRVEL 582
+ G+L A L E A A+ L AE++E + + AA + ++E + EL
Sbjct: 899 EVGELQGRVAQLEEERARLAEQLRAEAELCAEAEETRGRLAAR------KQELELVVSEL 952
Query: 583 QRERRRGEEQRDSFEGERLAWQAEKEQVIRYQKQLQHNYIQMYRRNRQLEQELQQLSLEL 642
E R GEE+ S QM ++L+Q +Q+L L
Sbjct: 953 --EARVGEEEECSR--------------------------QMQTEKKRLQQHIQELEAHL 984
Query: 643 EARE 646
EA E
Sbjct: 985 EAEE 988
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.129 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,413,575
Number of Sequences: 37866
Number of extensions: 2082879
Number of successful extensions: 34084
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 606
Number of HSP's successfully gapped in prelim test: 1821
Number of HSP's that attempted gapping in prelim test: 16068
Number of HSP's gapped (non-prelim): 12302
length of query: 669
length of database: 18,247,518
effective HSP length: 109
effective length of query: 560
effective length of database: 14,120,124
effective search space: 7907269440
effective search space used: 7907269440
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.