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Search of human proteins with 4507249
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
(540 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens] 1085 0.0
gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens] 561 e-160
gi|209180457 target of myb1 isoform 2 [Homo sapiens] 106 6e-23
gi|4885637 target of myb1 isoform 1 [Homo sapiens] 106 6e-23
gi|131888135 target of myb1-like 2 isoform 3 [Homo sapiens] 101 2e-21
gi|4758528 hepatocyte growth factor-regulated tyrosine kinase su... 91 3e-18
gi|209180450 target of myb1 isoform 4 [Homo sapiens] 88 2e-17
gi|209180448 target of myb1 isoform 3 [Homo sapiens] 87 3e-17
gi|191252812 target of myb1-like 1 [Homo sapiens] 76 9e-14
gi|20336267 ADP-ribosylation factor binding protein 3 isoform lo... 75 2e-13
gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens] 74 4e-13
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom... 70 6e-12
gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Ho... 70 6e-12
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 67 3e-11
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 67 4e-11
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 65 2e-10
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 65 2e-10
gi|9558729 golgi associated, gamma adaptin ear containing, ARF b... 64 3e-10
gi|48527952 golgi associated, gamma adaptin ear containing, ARF ... 64 3e-10
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 63 6e-10
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 60 4e-09
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 60 4e-09
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 60 4e-09
gi|9558751 ADP-ribosylation factor binding protein 2 [Homo sapiens] 59 1e-08
gi|46094081 development and differentiation enhancing factor 1 [... 59 1e-08
gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens] 58 3e-08
gi|4507247 SH3 and cysteine rich domain [Homo sapiens] 57 4e-08
gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo... 56 7e-08
gi|166235148 osteoclast stimulating factor 1 [Homo sapiens] 56 1e-07
gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo ... 55 1e-07
>gi|4507249 signal transducing adaptor molecule 1 [Homo sapiens]
Length = 540
Score = 1085 bits (2806), Expect = 0.0
Identities = 540/540 (100%), Positives = 540/540 (100%)
Query: 1 MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPH 60
MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPH
Sbjct: 1 MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPH 60
Query: 61 VAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFK 120
VAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFK
Sbjct: 61 VAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVLNKGHPKVCEKLKALMVEWTDEFK 120
Query: 121 NDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAI 180
NDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAI
Sbjct: 121 NDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAI 180
Query: 181 ELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVL 240
ELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVL
Sbjct: 181 ELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVL 240
Query: 241 DDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPEPA 300
DDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPEPA
Sbjct: 241 DDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPEPA 300
Query: 301 FIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSEL 360
FIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSEL
Sbjct: 301 FIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSEL 360
Query: 361 NVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAGNA 420
NVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAGNA
Sbjct: 361 NVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAGNA 420
Query: 421 QMSHLQSYSLPPEQLSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQAPVY 480
QMSHLQSYSLPPEQLSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQAPVY
Sbjct: 421 QMSHLQSYSLPPEQLSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQAPVY 480
Query: 481 SPPPAATAAAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQPYSQKALL 540
SPPPAATAAAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQPYSQKALL
Sbjct: 481 SPPPAATAAAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQPYSQKALL 540
>gi|188219625 signal transducing adaptor molecule 2 [Homo sapiens]
Length = 525
Score = 561 bits (1446), Expect = e-160
Identities = 301/539 (55%), Positives = 371/539 (68%), Gaps = 22/539 (4%)
Query: 1 MPLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPH 60
MPLF NPF+QDVEKAT+E NT EDW LI+DICDKVG + G KDCL++IM+RVNHK PH
Sbjct: 1 MPLFTANPFEQDVEKATNEYNTTEDWSLIMDICDKVGSTPNGAKDCLKAIMKRVNHKVPH 60
Query: 61 VAMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVL-NKGHPKVCEKLKALMVEWTDEF 119
VA+QALTLLGACV+NCGKIFHLEVCSRDFA+EV V+ NK HPKVCEKLK+LMVEW++EF
Sbjct: 61 VALQALTLLGACVANCGKIFHLEVCSRDFATEVRAVIKNKAHPKVCEKLKSLMVEWSEEF 120
Query: 120 KNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANK-KEEEDLAK 178
+ DPQ SLISA IK++KE+G+TFP GSQ A + GT +NK KE+ED+AK
Sbjct: 121 QKDPQFSLISATIKSMKEEGITFPPAGSQTVSAAAKN--------GTSSNKNKEDEDIAK 172
Query: 179 AIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIIT 238
AIELSL+EQ+QQ T +LYPS+ L N RKVRA+YDFEA EDNELTFK GEII
Sbjct: 173 AIELSLQEQKQQHTETKSLYPSSEIQLNN--KVARKVRALYDFEAVEDNELTFKHGEIII 230
Query: 239 VLDDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQVETIEPEPE 298
VLDDSD NWWKGE H+GIGLFPSNFVT +L E E +K V DDV+ E + EPE
Sbjct: 231 VLDDSDANWWKGENHRGIGLFPSNFVTTNLNIETEAAAVDKLNV-IDDDVE-EIKKSEPE 288
Query: 299 PAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELS 358
P +IDEDKMD+ LQ+LQS DP+D +PD +LL LE +C QMGP+IDEKLE+IDRKHSELS
Sbjct: 289 PVYIDEDKMDRALQVLQSIDPTDSKPDSQDLLDLEDICQQMGPMIDEKLEEIDRKHSELS 348
Query: 359 ELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQVYAGPPPSGAYLVAG 418
ELNVKV+EAL LY KL+NE P+YS+Y+KL +Y +S Q Y G Y+
Sbjct: 349 ELNVKVLEALELYNKLVNEAPVYSVYSKLHPPAHYPPASSGVPMQTYPVQSHGGNYMGQS 408
Query: 419 NAQMSHLQSYSLPPEQLSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQAP 478
Q++ QSYSL P+Q+ L +PP+ N ++ +Q Q +Y +T +V TY +Q
Sbjct: 409 IHQVTVAQSYSLGPDQIGPLRS--LPPNVNSSVTAQPAQTSYLSTGQDTVSNPTYMNQNS 466
Query: 479 VYSPPPAATA----AAATADVTLYQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQP 533
TA + D++ YQN N+PQ+ + +T P Q QQP
Sbjct: 467 NLQSATGTTAYTQQMGMSVDMSSYQNTTSNLPQLAGFPVTVPA--HPVAQQHTNYHQQP 523
>gi|209180457 target of myb1 isoform 2 [Homo sapiens]
Length = 493
Score = 106 bits (264), Expect = 6e-23
Identities = 55/143 (38%), Positives = 87/143 (60%), Gaps = 5/143 (3%)
Query: 6 TNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRR-VNHKDPHVAMQ 64
++P Q +EKAT +EDW L ++ICD + ++ GPKD LR++ +R V +K+ H M
Sbjct: 10 SSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVML 69
Query: 65 ALTLLGACVSNCGKIFHLEVCSRDFASE--VSNVLNKGHPK--VCEKLKALMVEWTDEFK 120
ALT+L CV NCG FH+ V S+DF V +L K +P V +K+ L+ W D F+
Sbjct: 70 ALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFR 129
Query: 121 NDPQLSLISAMIKNLKEQGVTFP 143
+ P L+ + + ++L+ +G+ FP
Sbjct: 130 SSPDLTGVVTIYEDLRRKGLEFP 152
Score = 29.3 bits (64), Expect = 9.6
Identities = 38/172 (22%), Positives = 63/172 (36%), Gaps = 21/172 (12%)
Query: 284 FSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLI 343
F + V V TI P+ P I DK+ L+Q D PDL ++ +
Sbjct: 94 FVESVLVRTILPKNNPPTIVHDKVLNLIQ--SWADAFRSSPDLTGVVTI----------- 140
Query: 344 DEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQ 403
ED+ RK E ++ ++ + + + S + + SG +
Sbjct: 141 ---YEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQHAAP 197
Query: 404 VYAGPPPSGAYLVAGNAQM-----SHLQSYSLPPEQLSSLSQAVVPPSANPA 450
+ A P SG +A + S L+ S +S + +VP A PA
Sbjct: 198 LPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPA 249
>gi|4885637 target of myb1 isoform 1 [Homo sapiens]
Length = 492
Score = 106 bits (264), Expect = 6e-23
Identities = 55/143 (38%), Positives = 87/143 (60%), Gaps = 5/143 (3%)
Query: 6 TNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRR-VNHKDPHVAMQ 64
++P Q +EKAT +EDW L ++ICD + ++ GPKD LR++ +R V +K+ H M
Sbjct: 10 SSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVML 69
Query: 65 ALTLLGACVSNCGKIFHLEVCSRDFASE--VSNVLNKGHPK--VCEKLKALMVEWTDEFK 120
ALT+L CV NCG FH+ V S+DF V +L K +P V +K+ L+ W D F+
Sbjct: 70 ALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFR 129
Query: 121 NDPQLSLISAMIKNLKEQGVTFP 143
+ P L+ + + ++L+ +G+ FP
Sbjct: 130 SSPDLTGVVTIYEDLRRKGLEFP 152
Score = 29.3 bits (64), Expect = 9.6
Identities = 38/172 (22%), Positives = 63/172 (36%), Gaps = 21/172 (12%)
Query: 284 FSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLI 343
F + V V TI P+ P I DK+ L+Q D PDL ++ +
Sbjct: 94 FVESVLVRTILPKNNPPTIVHDKVLNLIQ--SWADAFRSSPDLTGVVTI----------- 140
Query: 344 DEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQ 403
ED+ RK E ++ ++ + + + S + + SG +
Sbjct: 141 ---YEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQHAAP 197
Query: 404 VYAGPPPSGAYLVAGNAQM-----SHLQSYSLPPEQLSSLSQAVVPPSANPA 450
+ A P SG +A + S L+ S +S + +VP A PA
Sbjct: 198 LPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPA 249
>gi|131888135 target of myb1-like 2 isoform 3 [Homo sapiens]
Length = 507
Score = 101 bits (251), Expect = 2e-21
Identities = 69/244 (28%), Positives = 114/244 (46%), Gaps = 7/244 (2%)
Query: 6 TNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVN-HKDPHVAMQ 64
+ P Q +EKAT +EDW L ++ICD + ++ GPKD +R++ +R+N +++ M
Sbjct: 10 STPVGQCLEKATDGSLQSEDWTLNMEICDIINETEEGPKDAIRALKKRLNGNRNYREVML 69
Query: 65 ALTLLGACVSNCGKIFHLEVCSRDFASE--VSNVLNKGHPK--VCEKLKALMVEWTDEFK 120
ALT+L CV NCG FH+ V +RDF V + K +P V +K+ AL+ W D F+
Sbjct: 70 ALTVLETCVKNCGHRFHILVANRDFIDSVLVKIISPKNNPPTIVQDKVLALIQAWADAFR 129
Query: 121 NDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAK-DPGTVANKKEEEDLAKA 179
+ P L+ + + + LK +GV FP A V + DP + + + A
Sbjct: 130 SSPDLTGVVHIYEELKRKGVEFPMADLDALSPIHTPQRSVPEVDPAATMPRSQSQQRTSA 189
Query: 180 IELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITV 239
S S + T + N + R +R+ D ++ E++
Sbjct: 190 GSYSSPPPAPYSAPQAPALSVTGPITANSEQIAR-LRSELDVVRGNTKVMSEMLTEMVPG 248
Query: 240 LDDS 243
+DS
Sbjct: 249 QEDS 252
Score = 30.0 bits (66), Expect = 5.6
Identities = 31/129 (24%), Positives = 52/129 (40%), Gaps = 25/129 (19%)
Query: 284 FSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLI 343
F D V V+ I P+ P I +DK+ L+Q D PDL ++H+
Sbjct: 94 FIDSVLVKIISPKNNPPTIVQDKVLALIQAW--ADAFRSSPDLTGVVHI----------- 140
Query: 344 DEKLEDIDRKHSELSELNVKVMEALSLYTKLMNE-DPMYSMYAKLQNQPYYMQSSGVSGS 402
E++ RK E ++ + + + + E DP +M QS + +
Sbjct: 141 ---YEELKRKGVEFPMADLDALSPIHTPQRSVPEVDPAATMPRS--------QSQQRTSA 189
Query: 403 QVYAGPPPS 411
Y+ PPP+
Sbjct: 190 GSYSSPPPA 198
>gi|4758528 hepatocyte growth factor-regulated tyrosine kinase
substrate [Homo sapiens]
Length = 777
Score = 90.5 bits (223), Expect = 3e-18
Identities = 46/136 (33%), Positives = 78/136 (57%), Gaps = 1/136 (0%)
Query: 9 FDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTL 68
F++ ++KATS++ DW IL ICD + Q T K + SI ++VN K+PHVA+ AL +
Sbjct: 8 FERLLDKATSQLLLETDWESILQICDLIRQGDTQAKYAVNSIKKKVNDKNPHVALYALEV 67
Query: 69 LGACVSNCGKIFHLEVCSRDFASEVSNVLNKG-HPKVCEKLKALMVEWTDEFKNDPQLSL 127
+ + V NCG+ H EV ++ E+ ++L + V K+ L+ W F+N+P+ +
Sbjct: 68 MESVVKNCGQTVHDEVANKQTMEELKDLLKRQVEVNVRNKILYLIQAWAHAFRNEPKYKV 127
Query: 128 ISAMIKNLKEQGVTFP 143
+ + +K +G FP
Sbjct: 128 VQDTYQIMKVEGHVFP 143
Score = 31.6 bits (70), Expect = 1.9
Identities = 44/151 (29%), Positives = 60/151 (39%), Gaps = 30/151 (19%)
Query: 393 YMQSSGVSGSQV----YAGPPPSGAYLVAGNAQMSHLQSY-SLPPEQLSSLSQAVVPPSA 447
YM +G +G+Q AGP S AY + Q+ S P+ L ++SQ PP +
Sbjct: 635 YMYPAGATGAQAAPQAQAGPTASPAYSSYQPTPTAGYQNVASQAPQSLPAISQ---PPQS 691
Query: 448 NPA--LPSQQTQAAYPNTMVSSVQGNTYPSQAPVYSPPPAATAAAATADVTLYQNAGPNM 505
+ + SQ Y + ++ T PSQ S PP A +YQ P
Sbjct: 692 STMGYMGSQSVSMGYQPYNMQNLM-TTLPSQDA--SLPPQQPYIAGQQP--MYQQMAP-- 744
Query: 506 PQVPNYNLTSSTLPQPGGSQQPPQPQQPYSQ 536
S PQ QQPP QQP +Q
Sbjct: 745 ---------SGGPPQ----QQPPVAQQPQAQ 762
>gi|209180450 target of myb1 isoform 4 [Homo sapiens]
Length = 447
Score = 87.8 bits (216), Expect = 2e-17
Identities = 59/206 (28%), Positives = 100/206 (48%), Gaps = 27/206 (13%)
Query: 6 TNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRR-VNHKDPHVAMQ 64
++P Q +EKAT +EDW L ++ICD + ++ GPKD LR++ +R V +K+ H M
Sbjct: 10 SSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVGNKNFHEVML 69
Query: 65 ALTLLGACVSNCGKIFHLEVCSRDFASE--VSNVLNKGHPKVCEKLKALMVEWTDEFKND 122
ALT+L CV NCG FH+ V S+DF V +L K +P +D
Sbjct: 70 ALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPT--------------IVHD 115
Query: 123 PQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKA--------SPALVAKDPGTVANKKEEE 174
L+LI + + + G ++G+ +++Q + +P +++ D ++
Sbjct: 116 KVLNLIQTVFNSETQSGQ--DSVGTDSSQQEDSGQHAAPLPAPPILSGDTPIAPTPEQIG 173
Query: 175 DLAKAIELSLKEQRQQSTTLSTLYPS 200
L +E+ R S L+ L P+
Sbjct: 174 KLRSELEMVSGNVRVMSEMLTELVPT 199
>gi|209180448 target of myb1 isoform 3 [Homo sapiens]
Length = 460
Score = 87.4 bits (215), Expect = 3e-17
Identities = 45/119 (37%), Positives = 73/119 (61%), Gaps = 5/119 (4%)
Query: 30 LDICDKVGQSRTGPKDCLRSIMRR-VNHKDPHVAMQALTLLGACVSNCGKIFHLEVCSRD 88
++ICD + ++ GPKD LR++ +R V +K+ H M ALT+L CV NCG FH+ V S+D
Sbjct: 1 MEICDIINETEEGPKDALRAVKKRIVGNKNFHEVMLALTVLETCVKNCGHRFHVLVASQD 60
Query: 89 FASE--VSNVLNKGHPK--VCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFP 143
F V +L K +P V +K+ L+ W D F++ P L+ + + ++L+ +G+ FP
Sbjct: 61 FVESVLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSSPDLTGVVTIYEDLRRKGLEFP 119
Score = 29.3 bits (64), Expect = 9.6
Identities = 38/172 (22%), Positives = 63/172 (36%), Gaps = 21/172 (12%)
Query: 284 FSDDVQVETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPELLHLEAMCHQMGPLI 343
F + V V TI P+ P I DK+ L+Q D PDL ++ +
Sbjct: 61 FVESVLVRTILPKNNPPTIVHDKVLNLIQ--SWADAFRSSPDLTGVVTI----------- 107
Query: 344 DEKLEDIDRKHSELSELNVKVMEALSLYTKLMNEDPMYSMYAKLQNQPYYMQSSGVSGSQ 403
ED+ RK E ++ ++ + + + S + + SG +
Sbjct: 108 ---YEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDSVGTDSSQQEDSGQHAAP 164
Query: 404 VYAGPPPSGAYLVAGNAQM-----SHLQSYSLPPEQLSSLSQAVVPPSANPA 450
+ A P SG +A + S L+ S +S + +VP A PA
Sbjct: 165 LPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTELVPTQAEPA 216
>gi|191252812 target of myb1-like 1 [Homo sapiens]
Length = 476
Score = 75.9 bits (185), Expect = 9e-14
Identities = 44/161 (27%), Positives = 83/161 (51%), Gaps = 10/161 (6%)
Query: 13 VEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQ-ALTLLGA 71
+EKAT EDWG + ICD + ++ GPKD ++++ +R++ H +Q L+L+
Sbjct: 19 IEKATFAGVQTEDWGQFMHICDIINTTQDGPKDAVKALKKRISKNYNHKEIQLTLSLIDM 78
Query: 72 CVSNCGKIFHLEVCSRDFASEVSNVLNKGHPK------VCEKLKALMVEWTDEFKNDPQL 125
CV NCG F + ++F E N++ +P+ + ++ + W+ F +
Sbjct: 79 CVQNCGPSFQSLIVKKEFVKE--NLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGGVDV 136
Query: 126 SLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGT 166
S + + +L ++GV FP ++ AE A+ A ++ +P T
Sbjct: 137 SEVKEVYLDLVKKGVQFPPSEAE-AETARQETAQISSNPPT 176
>gi|20336267 ADP-ribosylation factor binding protein 3 isoform long
[Homo sapiens]
Length = 723
Score = 75.1 bits (183), Expect = 2e-13
Identities = 44/134 (32%), Positives = 71/134 (52%), Gaps = 9/134 (6%)
Query: 13 VEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGAC 72
+ KAT+ N EDW I+ CD++ + GP+ +R + ++ A+QALT+L AC
Sbjct: 13 LNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEWEALQALTVLEAC 72
Query: 73 VSNCGKIFHLEVCSRDFASEVSNVLNKGH--PKVCEKLKALMVE----WTDEFKNDPQLS 126
+ NCG+ FH EV F +E+ V++ + +V EK+K ++E WT P+ +
Sbjct: 73 MKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYSWTMAL---PEEA 129
Query: 127 LISAMIKNLKEQGV 140
I LK QG+
Sbjct: 130 KIKDAYHMLKRQGI 143
>gi|4758476 GRB2-related adaptor protein 2 [Homo sapiens]
Length = 330
Score = 73.6 bits (179), Expect = 4e-13
Identities = 30/52 (57%), Positives = 40/52 (76%)
Query: 213 RKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
R RA+YDFEA ED+EL F +GE++ VLD S+P+WW G H +GLFP+N+V
Sbjct: 274 RWARALYDFEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYV 325
Score = 37.7 bits (86), Expect = 0.027
Identities = 16/48 (33%), Positives = 29/48 (60%), Gaps = 1/48 (2%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
A +DF A+ ++EL+F G+++ +L + + W+K E G P NF+
Sbjct: 5 AKFDFTASGEDELSFHTGDVLKILSNQE-EWFKAELGSQEGYVPKNFI 51
>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
sapiens]
Length = 217
Score = 69.7 bits (169), Expect = 6e-12
Identities = 28/51 (54%), Positives = 38/51 (74%)
Query: 215 VRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVT 265
V+A++DF+ ED EL F+ G+ I V+D+SDPNWWKG H G+FP N+VT
Sbjct: 161 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVT 211
Score = 48.9 bits (115), Expect = 1e-05
Identities = 22/49 (44%), Positives = 33/49 (67%), Gaps = 1/49 (2%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVL-DDSDPNWWKGETHQGIGLFPSNFV 264
A YDF+A D+EL+FK G+I+ VL ++ D NW+K E + G P N++
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI 53
>gi|45359859 growth factor receptor-bound protein 2 isoform 2 [Homo
sapiens]
Length = 176
Score = 69.7 bits (169), Expect = 6e-12
Identities = 28/51 (54%), Positives = 38/51 (74%)
Query: 215 VRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVT 265
V+A++DF+ ED EL F+ G+ I V+D+SDPNWWKG H G+FP N+VT
Sbjct: 120 VQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVT 170
Score = 49.7 bits (117), Expect = 7e-06
Identities = 28/74 (37%), Positives = 40/74 (54%), Gaps = 14/74 (18%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVL-DDSDPNWWKGETHQGIGLFPSNFVTADLTAEPEMI 275
A YDF+A D+EL+FK G+I+ VL ++ D NW+K E + G P N++
Sbjct: 5 AKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYI----------- 53
Query: 276 KTEKKTVQFSDDVQ 289
E K F +DVQ
Sbjct: 54 --EMKPHPFGNDVQ 65
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 67.4 bits (163), Expect = 3e-11
Identities = 52/190 (27%), Positives = 88/190 (46%), Gaps = 26/190 (13%)
Query: 197 LYPSTSSLLTNHQHEGRKVRAI------YDFEAAEDNELTFKAGEIITVLDDSDPNWWKG 250
L P TS + + + A+ YD+ A D+EL F G+II VL+ DP+WWKG
Sbjct: 1136 LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG 1195
Query: 251 ETHQGIGLFPSNFVTADLTAEPEMIKTEKKTVQFSDDVQ-VETIEPEPEPAFIDEDKMDQ 309
E + +GLFPSN+V +P Q+ D+ ++ + P E K
Sbjct: 1196 EVNGQVGLFPSNYVKLTTDMDPSQ--------QWCSDLHLLDMLTP-------TERKRQG 1240
Query: 310 LLQMLQSTDPS--DDQPDLPELLHLEAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEA 367
+ L T+ + +D + E+ M ++ L ++++ I EL N+K+++A
Sbjct: 1241 YIHELIVTEENYVNDLQLVTEIFQKPLMESEL--LTEKEVAMIFVNWKELIMCNIKLLKA 1298
Query: 368 LSLYTKLMNE 377
L + K+ E
Sbjct: 1299 LRVRKKMSGE 1308
Score = 48.9 bits (115), Expect = 1e-05
Identities = 28/79 (35%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
Query: 187 QRQQSTTLSTLYPSTSSLLTNHQH-EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDP 245
QR T + S S +L + EG + +A+Y + A +DN L F ++ITVL+ D
Sbjct: 889 QRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQD- 947
Query: 246 NWWKGETHQGIGLFPSNFV 264
WW GE G FP ++V
Sbjct: 948 MWWFGEVQGQKGWFPKSYV 966
Score = 48.1 bits (113), Expect = 2e-05
Identities = 21/53 (39%), Positives = 33/53 (62%), Gaps = 1/53 (1%)
Query: 212 GRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
G + A+Y +E++E +LTF+ G++I V D +WW G G+FPSN+V
Sbjct: 1004 GEEFIAMYTYESSEQGDLTFQQGDVILV-TKKDGDWWTGTVGDKAGVFPSNYV 1055
Score = 39.3 bits (90), Expect = 0.009
Identities = 25/69 (36%), Positives = 37/69 (53%), Gaps = 10/69 (14%)
Query: 205 LTNHQHEGRKV---RAIYDFEAAEDNELTFKAGEIITV----LDDS---DPNWWKGETHQ 254
LT E KV RA+Y FE+ +E+T + G+I+ V +D+S +P W GE
Sbjct: 732 LTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKG 791
Query: 255 GIGLFPSNF 263
G FP+N+
Sbjct: 792 KTGWFPANY 800
Score = 35.0 bits (79), Expect = 0.17
Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 15/115 (13%)
Query: 216 RAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETH-----QGIGLFPSNFVTADLTA 270
+ I + A +LT G++I + + WW+GE + IG FP+N+V
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 271 EPEMIKTE-KKTVQFSDDVQV-----ETIEPEPEPAFIDEDKMDQLLQMLQSTDP 319
++ TE K+ + QV T + + E AF Q++ +L DP
Sbjct: 1140 TSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF----NKGQIINVLNKEDP 1190
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 67.0 bits (162), Expect = 4e-11
Identities = 32/82 (39%), Positives = 45/82 (54%), Gaps = 6/82 (7%)
Query: 197 LYPSTSSLLTNHQHEGRKVRAI------YDFEAAEDNELTFKAGEIITVLDDSDPNWWKG 250
L P TS + + + A+ YD+ A D+EL F G+II VL+ DP+WWKG
Sbjct: 1136 LSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKG 1195
Query: 251 ETHQGIGLFPSNFVTADLTAEP 272
E + +GLFPSN+V +P
Sbjct: 1196 EVNGQVGLFPSNYVKLTTDMDP 1217
Score = 48.9 bits (115), Expect = 1e-05
Identities = 28/79 (35%), Positives = 41/79 (51%), Gaps = 2/79 (2%)
Query: 187 QRQQSTTLSTLYPSTSSLLTNHQH-EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDP 245
QR T + S S +L + EG + +A+Y + A +DN L F ++ITVL+ D
Sbjct: 889 QRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQD- 947
Query: 246 NWWKGETHQGIGLFPSNFV 264
WW GE G FP ++V
Sbjct: 948 MWWFGEVQGQKGWFPKSYV 966
Score = 48.1 bits (113), Expect = 2e-05
Identities = 21/53 (39%), Positives = 33/53 (62%), Gaps = 1/53 (1%)
Query: 212 GRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
G + A+Y +E++E +LTF+ G++I V D +WW G G+FPSN+V
Sbjct: 1004 GEEFIAMYTYESSEQGDLTFQQGDVILV-TKKDGDWWTGTVGDKAGVFPSNYV 1055
Score = 39.3 bits (90), Expect = 0.009
Identities = 25/69 (36%), Positives = 37/69 (53%), Gaps = 10/69 (14%)
Query: 205 LTNHQHEGRKV---RAIYDFEAAEDNELTFKAGEIITV----LDDS---DPNWWKGETHQ 254
LT E KV RA+Y FE+ +E+T + G+I+ V +D+S +P W GE
Sbjct: 732 LTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKG 791
Query: 255 GIGLFPSNF 263
G FP+N+
Sbjct: 792 KTGWFPANY 800
Score = 35.0 bits (79), Expect = 0.17
Identities = 29/115 (25%), Positives = 49/115 (42%), Gaps = 15/115 (13%)
Query: 216 RAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETH-----QGIGLFPSNFVTADLTA 270
+ I + A +LT G++I + + WW+GE + IG FP+N+V
Sbjct: 1080 QVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSPG 1139
Query: 271 EPEMIKTE-KKTVQFSDDVQV-----ETIEPEPEPAFIDEDKMDQLLQMLQSTDP 319
++ TE K+ + QV T + + E AF Q++ +L DP
Sbjct: 1140 TSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAF----NKGQIINVLNKEDP 1190
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 65.1 bits (157), Expect = 2e-10
Identities = 46/170 (27%), Positives = 88/170 (51%), Gaps = 18/170 (10%)
Query: 210 HEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLT 269
H +V A+YD+ A ++EL+F G++I V++ DP+WW+GE + GLFPSN+V
Sbjct: 1100 HPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTD 1159
Query: 270 AEPEMIKTEKKTVQFSDDVQ-VETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPE 328
++P Q+ D+Q ++T++P I+ + + +++Q+ + DL
Sbjct: 1160 SDPSQ--------QWCADLQTLDTMQP------IERKRQGYIHELIQTEERY--MADLQL 1203
Query: 329 LLHL-EAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNE 377
++ + + + G L + ++ I EL N K+++AL + K E
Sbjct: 1204 VVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGE 1253
Score = 51.2 bits (121), Expect = 2e-06
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
E K +A+ + A +DN L F +IITVL+ + NWW GE H G G FP ++V
Sbjct: 872 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFPKSYV 924
Score = 50.1 bits (118), Expect = 5e-06
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 11/117 (9%)
Query: 170 KKEEEDLAKAIELSLKEQRQQSTTLSTLYPS--TSSLLTNHQHEGRKVRAIYDFEAAEDN 227
+K +E + + + ++QR+ TL T+S+L N+ RA+Y FEA +
Sbjct: 695 EKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNY-------RALYPFEARNHD 747
Query: 228 ELTFKAGEIITVLDDS--DPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTV 282
E++F +G+II V + + +P W G G FP N+V ++E E + KK +
Sbjct: 748 EMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKAL 804
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/166 (27%), Positives = 65/166 (39%), Gaps = 25/166 (15%)
Query: 100 GHPKVCEKLKA-LMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPA 158
G +V E LKA + WT K D L+ I + EQ + G + +
Sbjct: 866 GQGQVVENLKAQALCSWTA--KKDNHLNFSKHDIITVLEQQENW-WFGEVHGGRGWFPKS 922
Query: 159 LVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAI 218
V PG+ ++E E L A+ ++ S S G + A+
Sbjct: 923 YVKIIPGSEVKREEPEALYAAVN-----KKPTSAAYSV---------------GEEYIAL 962
Query: 219 YDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
Y + + E +LTF GE I V D WW G G+FPSN+V
Sbjct: 963 YPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYV 1007
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 65.1 bits (157), Expect = 2e-10
Identities = 46/170 (27%), Positives = 88/170 (51%), Gaps = 18/170 (10%)
Query: 210 HEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLT 269
H +V A+YD+ A ++EL+F G++I V++ DP+WW+GE + GLFPSN+V
Sbjct: 1127 HPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTD 1186
Query: 270 AEPEMIKTEKKTVQFSDDVQ-VETIEPEPEPAFIDEDKMDQLLQMLQSTDPSDDQPDLPE 328
++P Q+ D+Q ++T++P I+ + + +++Q+ + DL
Sbjct: 1187 SDPSQ--------QWCADLQTLDTMQP------IERKRQGYIHELIQTEERY--MADLQL 1230
Query: 329 LLHL-EAMCHQMGPLIDEKLEDIDRKHSELSELNVKVMEALSLYTKLMNE 377
++ + + + G L + ++ I EL N K+++AL + K E
Sbjct: 1231 VVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGE 1280
Score = 51.2 bits (121), Expect = 2e-06
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
E K +A+ + A +DN L F +IITVL+ + NWW GE H G G FP ++V
Sbjct: 899 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFPKSYV 951
Score = 50.1 bits (118), Expect = 5e-06
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 11/117 (9%)
Query: 170 KKEEEDLAKAIELSLKEQRQQSTTLSTLYPS--TSSLLTNHQHEGRKVRAIYDFEAAEDN 227
+K +E + + + ++QR+ TL T+S+L N+ RA+Y FEA +
Sbjct: 722 EKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNY-------RALYPFEARNHD 774
Query: 228 ELTFKAGEIITVLDDS--DPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTV 282
E++F +G+II V + + +P W G G FP N+V ++E E + KK +
Sbjct: 775 EMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKAL 831
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/166 (27%), Positives = 65/166 (39%), Gaps = 25/166 (15%)
Query: 100 GHPKVCEKLKA-LMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPA 158
G +V E LKA + WT K D L+ I + EQ + G + +
Sbjct: 893 GQGQVVENLKAQALCSWTA--KKDNHLNFSKHDIITVLEQQENW-WFGEVHGGRGWFPKS 949
Query: 159 LVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAI 218
V PG+ ++E E L A+ ++ S S G + A+
Sbjct: 950 YVKIIPGSEVKREEPEALYAAVN-----KKPTSAAYSV---------------GEEYIAL 989
Query: 219 YDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
Y + + E +LTF GE I V D WW G G+FPSN+V
Sbjct: 990 YPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYV 1034
>gi|9558729 golgi associated, gamma adaptin ear containing, ARF
binding protein 1 isoform 1 [Homo sapiens]
Length = 639
Score = 64.3 bits (155), Expect = 3e-10
Identities = 40/145 (27%), Positives = 68/145 (46%), Gaps = 9/145 (6%)
Query: 2 PLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHV 61
P + + +AT+ +N DW I C+++ + GP R + ++
Sbjct: 3 PAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWE 62
Query: 62 AMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVL------NKGHPKVCEKLKALMVEW 115
A+QALT+L C+ +CGK FH EV F +E+ V+ ++ KV K+ L+ W
Sbjct: 63 AIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSW 122
Query: 116 TDEFKNDPQLSLISAMIKNLKEQGV 140
T P+ I+ + LK+QG+
Sbjct: 123 TVGL---PEEVKIAEAYQMLKKQGI 144
>gi|48527952 golgi associated, gamma adaptin ear containing, ARF
binding protein 1 isoform 2 [Homo sapiens]
Length = 552
Score = 64.3 bits (155), Expect = 3e-10
Identities = 40/145 (27%), Positives = 68/145 (46%), Gaps = 9/145 (6%)
Query: 2 PLFATNPFDQDVEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHV 61
P + + +AT+ +N DW I C+++ + GP R + ++
Sbjct: 3 PAMEPETLEARINRATNPLNKELDWASINGFCEQLNEDFEGPPLATRLLAHKIQSPQEWE 62
Query: 62 AMQALTLLGACVSNCGKIFHLEVCSRDFASEVSNVL------NKGHPKVCEKLKALMVEW 115
A+QALT+L C+ +CGK FH EV F +E+ V+ ++ KV K+ L+ W
Sbjct: 63 AIQALTVLETCMKSCGKRFHDEVGKFRFLNELIKVVSPKYLGSRTSEKVKNKILELLYSW 122
Query: 116 TDEFKNDPQLSLISAMIKNLKEQGV 140
T P+ I+ + LK+QG+
Sbjct: 123 TVGL---PEEVKIAEAYQMLKKQGI 144
Score = 30.4 bits (67), Expect = 4.3
Identities = 62/284 (21%), Positives = 108/284 (38%), Gaps = 40/284 (14%)
Query: 273 EMIKTE---KKTVQFSDDVQVETIEPEPEPA-FIDEDKMDQLLQMLQSTDPSDDQPDLPE 328
+M+K + K + DD P P+ F DE+K L ++L+S+ P D
Sbjct: 137 QMLKKQGIVKSDPKLPDDTTFPLPPPRPKNVIFEDEEKSKMLARLLKSSHPED------- 189
Query: 329 LLHLEAMCHQMGPLIDEKLEDIDRKHSELSEL--NVKVMEALSLYTKL------MNEDPM 380
L + +M +++E I ++ + + E+ NVK++ + + +ED M
Sbjct: 190 LRAANKLIKEMVQEDQKRMEKISKRVNAIEEVNNNVKLLTEMVMSHSQGGAAAGSSEDLM 249
Query: 381 YSMYAKLQNQ--PYYMQSSGVSGSQVYAG----PPPSGAYLVAGNAQMSHLQSYSLPPEQ 434
+Y + + + +S + G PPSG L + QS
Sbjct: 250 KELYQRCERMRPTLFRLASDTEDNDEALGLSDPTPPSGPSL--DGTGWNSFQSSDATEPP 307
Query: 435 LSSLSQAVVPPSANPALPSQQTQAAYPNTMVSSVQGNTYPSQA-PVYSPPPAATAAAATA 493
+L+QA PS P+Q + A + G T Q+ P S T
Sbjct: 308 APALAQA---PSMESRPPAQTSLPASSGLDDLDLLGKTLLQQSLPPESQQVRWEKQQPTP 364
Query: 494 DVTL----YQNAGPNMPQVPNYNLTSSTLPQPGGSQQPPQPQQP 533
+TL +++ + P +L + P+P P PQQP
Sbjct: 365 RLTLRDLQNKSSSCSSPSSSATSLLHTVSPEP-----PRPPQQP 403
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 63.2 bits (152), Expect = 6e-10
Identities = 31/87 (35%), Positives = 53/87 (60%), Gaps = 9/87 (10%)
Query: 210 HEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFVTADLT 269
H +V A+YD+ A ++EL+F G++I V++ DP+WW+GE + GLFPSN+V
Sbjct: 1127 HPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTD 1186
Query: 270 AEPEMIKTEKKTVQFSDDVQ-VETIEP 295
++P Q+ D+Q ++T++P
Sbjct: 1187 SDPSQ--------QWCADLQTLDTMQP 1205
Score = 51.2 bits (121), Expect = 2e-06
Identities = 24/54 (44%), Positives = 33/54 (61%), Gaps = 1/54 (1%)
Query: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
E K +A+ + A +DN L F +IITVL+ + NWW GE H G G FP ++V
Sbjct: 899 ENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFPKSYV 951
Score = 50.1 bits (118), Expect = 5e-06
Identities = 34/117 (29%), Positives = 59/117 (50%), Gaps = 11/117 (9%)
Query: 170 KKEEEDLAKAIELSLKEQRQQSTTLSTLYPS--TSSLLTNHQHEGRKVRAIYDFEAAEDN 227
+K +E + + + ++QR+ TL T+S+L N+ RA+Y FEA +
Sbjct: 722 EKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNY-------RALYPFEARNHD 774
Query: 228 ELTFKAGEIITVLDDS--DPNWWKGETHQGIGLFPSNFVTADLTAEPEMIKTEKKTV 282
E++F +G+II V + + +P W G G FP N+V ++E E + KK +
Sbjct: 775 EMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKAL 831
Score = 44.3 bits (103), Expect = 3e-04
Identities = 45/166 (27%), Positives = 65/166 (39%), Gaps = 25/166 (15%)
Query: 100 GHPKVCEKLKA-LMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPA 158
G +V E LKA + WT K D L+ I + EQ + G + +
Sbjct: 893 GQGQVVENLKAQALCSWTA--KKDNHLNFSKHDIITVLEQQENW-WFGEVHGGRGWFPKS 949
Query: 159 LVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGRKVRAI 218
V PG+ ++E E L A+ ++ S S G + A+
Sbjct: 950 YVKIIPGSEVKREEPEALYAAVN-----KKPTSAAYSV---------------GEEYIAL 989
Query: 219 YDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
Y + + E +LTF GE I V D WW G G+FPSN+V
Sbjct: 990 YPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYV 1034
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 60.5 bits (145), Expect = 4e-09
Identities = 25/54 (46%), Positives = 37/54 (68%)
Query: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
+GRK +A+YDF ++EL+FKAG+IIT L+ D +W GE G+FP N++
Sbjct: 672 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYI 725
Score = 45.8 bits (107), Expect = 1e-04
Identities = 17/47 (36%), Positives = 32/47 (68%)
Query: 218 IYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
++DF A + ++L +GEI+ +L+ D +W++G IG+FP+N+V
Sbjct: 444 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV 490
Score = 41.6 bits (96), Expect = 0.002
Identities = 19/60 (31%), Positives = 35/60 (58%)
Query: 205 LTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
+++H +G + A +++ + +EL+F GEII + + + W +GE G+FP NFV
Sbjct: 507 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFV 566
Score = 40.0 bits (92), Expect = 0.005
Identities = 17/48 (35%), Positives = 29/48 (60%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
A++ F A ++L+FK G+ I +L+ D +W +G G+FP+ FV
Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 656
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 60.5 bits (145), Expect = 4e-09
Identities = 25/54 (46%), Positives = 37/54 (68%)
Query: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
+GRK +A+YDF ++EL+FKAG+IIT L+ D +W GE G+FP N++
Sbjct: 708 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYI 761
Score = 45.8 bits (107), Expect = 1e-04
Identities = 17/47 (36%), Positives = 32/47 (68%)
Query: 218 IYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
++DF A + ++L +GEI+ +L+ D +W++G IG+FP+N+V
Sbjct: 480 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV 526
Score = 41.6 bits (96), Expect = 0.002
Identities = 19/60 (31%), Positives = 35/60 (58%)
Query: 205 LTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
+++H +G + A +++ + +EL+F GEII + + + W +GE G+FP NFV
Sbjct: 543 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFV 602
Score = 40.0 bits (92), Expect = 0.005
Identities = 17/48 (35%), Positives = 29/48 (60%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
A++ F A ++L+FK G+ I +L+ D +W +G G+FP+ FV
Sbjct: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 692
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 60.5 bits (145), Expect = 4e-09
Identities = 25/54 (46%), Positives = 37/54 (68%)
Query: 211 EGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
+GRK +A+YDF ++EL+FKAG+IIT L+ D +W GE G+FP N++
Sbjct: 731 KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYI 784
Score = 45.8 bits (107), Expect = 1e-04
Identities = 17/47 (36%), Positives = 32/47 (68%)
Query: 218 IYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
++DF A + ++L +GEI+ +L+ D +W++G IG+FP+N+V
Sbjct: 503 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYV 549
Score = 41.6 bits (96), Expect = 0.002
Identities = 19/60 (31%), Positives = 35/60 (58%)
Query: 205 LTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
+++H +G + A +++ + +EL+F GEII + + + W +GE G+FP NFV
Sbjct: 566 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFV 625
Score = 40.0 bits (92), Expect = 0.005
Identities = 17/48 (35%), Positives = 29/48 (60%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
A++ F A ++L+FK G+ I +L+ D +W +G G+FP+ FV
Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFV 715
>gi|9558751 ADP-ribosylation factor binding protein 2 [Homo sapiens]
Length = 613
Score = 58.9 bits (141), Expect = 1e-08
Identities = 37/134 (27%), Positives = 64/134 (47%), Gaps = 9/134 (6%)
Query: 13 VEKATSEMNTAEDWGLILDICDKVGQSRTGPKDCLRSIMRRVNHKDPHVAMQALTLLGAC 72
+ KAT + +DW I + C++V GP + ++ A+ ALT+L C
Sbjct: 30 LNKATDPSMSEQDWSAIQNFCEQVNTDPNGPTHAPWLLAHKIQSPQEKEALYALTVLEMC 89
Query: 73 VSNCGKIFHLEVCSRDFASEVSNVLNKGH------PKVCEKLKALMVEWTDEFKNDPQLS 126
+++CG+ FH EV F +E+ VL+ + KV ++ ++ WT F D +
Sbjct: 90 MNHCGEKFHSEVAKFRFLNELIKVLSPKYLGSWATGKVKGRVIEILFSWTVWFPEDIK-- 147
Query: 127 LISAMIKNLKEQGV 140
I + LK+QG+
Sbjct: 148 -IRDAYQMLKKQGI 160
>gi|46094081 development and differentiation enhancing factor 1 [Homo
sapiens]
Length = 1129
Score = 58.5 bits (140), Expect = 1e-08
Identities = 38/132 (28%), Positives = 61/132 (46%), Gaps = 10/132 (7%)
Query: 143 PAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTS 202
P +G A+ + A+ P V K DL+ ++ Q+Q S + L P+
Sbjct: 993 PQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLP 1052
Query: 203 SL-------LTNHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETH-- 253
+ +++ R+V+ IYD +A D+ELTF GE+I V + D WW G
Sbjct: 1053 ETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQ 1112
Query: 254 -QGIGLFPSNFV 264
+ G+FP +FV
Sbjct: 1113 PERKGVFPVSFV 1124
>gi|21450838 SH3 and cysteine rich domain 3 [Homo sapiens]
Length = 364
Score = 57.8 bits (138), Expect = 3e-08
Identities = 23/48 (47%), Positives = 34/48 (70%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
A+Y F+A E ++L F GE ITV+DDS+ WW+G+ + +G FP NF+
Sbjct: 254 ALYRFKALEKDDLDFPPGEKITVIDDSNEEWWRGKIGEKVGFFPPNFI 301
>gi|4507247 SH3 and cysteine rich domain [Homo sapiens]
Length = 402
Score = 57.0 bits (136), Expect = 4e-08
Identities = 23/48 (47%), Positives = 34/48 (70%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
A+Y F E+ +L + G+IIT+L+DS+ +WWKG+ IG FP+NFV
Sbjct: 292 ALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFV 339
>gi|227430336 SH3 domain containing, Ysc84-like 1 isoform 1 [Homo
sapiens]
Length = 342
Score = 56.2 bits (134), Expect = 7e-08
Identities = 44/171 (25%), Positives = 80/171 (46%), Gaps = 34/171 (19%)
Query: 102 PKVCEKLKALMVEWTDEFKNDPQLSLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVA 161
P E L ++ +T++++N+ Q I+A +++ + + + + + S A V
Sbjct: 197 PAQAEDLYEILDSFTEKYENEGQR--INARKAAREQRKSSAKELPPKPLSRPQQSSAPVQ 254
Query: 162 KDPGTVANKKEEEDLAKAIELSLKEQRQQSTTLSTLYPSTSSLLTNHQHEGR-----KVR 216
+ G+ +N+ E + LYP SS H+ G +V
Sbjct: 255 LNSGSQSNRNEYK----------------------LYPGLSSY---HERVGNLNQPIEVT 289
Query: 217 AIYDFEAAEDNELTFKAGEIITVLD--DSDPNWWKGETHQGIGLFPSNFVT 265
A+Y FE + +L F+AG+ ITV+ DS +WW+G+ G+FP+N+VT
Sbjct: 290 ALYSFEGQQPGDLNFQAGDRITVISKTDSHFDWWEGKLRGQTGIFPANYVT 340
>gi|166235148 osteoclast stimulating factor 1 [Homo sapiens]
Length = 214
Score = 55.8 bits (133), Expect = 1e-07
Identities = 25/49 (51%), Positives = 32/49 (65%)
Query: 216 RAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQGIGLFPSNFV 264
RA+Y FE +EL F+ G+II + D SD NWWKG + GL PSN+V
Sbjct: 18 RALYTFEPRTPDELYFEEGDIIYITDMSDTNWWKGTSKGRTGLIPSNYV 66
>gi|224586855 sorbin and SH3 domain containing 2 isoform 8 [Homo
sapiens]
Length = 492
Score = 55.5 bits (132), Expect = 1e-07
Identities = 37/143 (25%), Positives = 61/143 (42%), Gaps = 4/143 (2%)
Query: 126 SLISAMIKNLKEQGVTFPAIGSQAAEQAKASPALVAKDPGTVANKKEEEDLAKAIELSLK 185
S+ S K K + P G ++ SP V + K + + K
Sbjct: 167 SMASDFRKRRKSEPAVGPPRGLGDQSASRTSPGRVDLPGSSTTLTKSFTSSSPSSPSRAK 226
Query: 186 EQRQQSTTLSTLYPSTSSLLTNHQHEGRK----VRAIYDFEAAEDNELTFKAGEIITVLD 241
++ + STL S + K +A+YDF+A EL+FK G+ + +L
Sbjct: 227 DRESPRSYSSTLTDMGRSAPRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILR 286
Query: 242 DSDPNWWKGETHQGIGLFPSNFV 264
D NW++GE H +G+FP ++V
Sbjct: 287 KIDQNWYEGEHHGRVGIFPISYV 309
Score = 38.1 bits (87), Expect = 0.021
Identities = 17/60 (28%), Positives = 32/60 (53%), Gaps = 2/60 (3%)
Query: 207 NHQHEGRKVRAIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGETHQG--IGLFPSNFV 264
N Q G +A+Y++ ++EL + ++I V++ D W+ G + + G FP N+V
Sbjct: 430 NIQGGGEPFQALYNYTPRNEDELELRESDVIDVMEKCDDGWFVGTSRRTKFFGTFPGNYV 489
Score = 31.6 bits (70), Expect = 1.9
Identities = 16/50 (32%), Positives = 29/50 (58%), Gaps = 2/50 (4%)
Query: 217 AIYDFEAAEDNELTFKAGEIITVLDDSDPNWWKGET--HQGIGLFPSNFV 264
A Y+F A + EL+ + G+ + +L D NW++G+ G+FP ++V
Sbjct: 337 AKYNFNADTNVELSLRKGDRVILLKRVDQNWYEGKIPGTNRQGIFPVSYV 386
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.127 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,342,594
Number of Sequences: 37866
Number of extensions: 1067195
Number of successful extensions: 5896
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 244
Number of HSP's successfully gapped in prelim test: 368
Number of HSP's that attempted gapping in prelim test: 4814
Number of HSP's gapped (non-prelim): 1321
length of query: 540
length of database: 18,247,518
effective HSP length: 107
effective length of query: 433
effective length of database: 14,195,856
effective search space: 6146805648
effective search space used: 6146805648
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.