Guide to the Human Genome
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Name: SHH Sequence: fasta or formatted (462aa) NCBI GI: 4506939
Description:

sonic hedgehog preproprotein

Referenced in:

Hedgehog and Related Pathways

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine            12.3         57           2
 C cysteine            1.5          7           1
 D aspartate           5.6         26           2
 E glutamate           5.6         26           2
 F phenylalanine       2.8         13           1
 G glycine            10.6         49           5
 H histidine           3.2         15           2
 I isoleucine          2.8         13           2
 K lysine              4.3         20           2
 L leucine            11.5         53           3
 M methionine          1.1          5           1
 N asparagine          2.2         10           1
 P proline             5.0         23           2
 Q glutamine           1.9          9           1
 R arginine            7.4         34           2
 S serine              7.1         33           2
 T threonine           4.5         21           2
 V valine              6.1         28           2
 W tryptophan          1.3          6           1
 Y tyrosine            3.0         14           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   sonic hedgehog preproprotein 
IHH                   0.500   Indian hedgehog homolog 
DHH                   0.460   desert hedgehog preproprotein 
POU3F3                0.013   POU class 3 homeobox 3 
EVX2                  0.013   even-skipped homeobox 2 
SUZ12                 0.011   joined to JAZF1 
LOC100292058          0.011   PREDICTED: hypothetical protein XP_002344766 
LOC100290367          0.011   PREDICTED: hypothetical protein XP_002347417 
LOC100288730          0.011   PREDICTED: hypothetical protein XP_002343287 
ANO8                  0.010   anoctamin 8 
ZIC2                  0.010   zinc finger protein of the cerebellum 2 
KCNQ3                 0.010   potassium voltage-gated channel KQT-like protein 3 [H...
CCDC85C               0.009   coiled-coil domain containing 85C 
SOX4                  0.009   SRY (sex determining region Y)-box 4 
FUSSEL18              0.009   PREDICTED: functional smad suppressing element 18 [...
FUSSEL18              0.009   PREDICTED: functional smad suppressing element 18 [...
FUSSEL18              0.009   PREDICTED: functional smad suppressing element 18 [...
ZNF282                0.009   zinc finger protein 282 
RFX1                  0.009   regulatory factor X1 
LOC645602             0.009   PREDICTED: hypothetical protein 
LOC645602             0.009   PREDICTED: hypothetical protein 
LOC645602             0.009   PREDICTED: hypothetical protein 
KIF26A                0.009   kinesin family member 26A 
GDF7                  0.009   growth differentiation factor 7 preproprotein 
DACH1                 0.008   dachshund homolog 1 isoform b 
DACH1                 0.008   dachshund homolog 1 isoform a 
DACH1                 0.008   dachshund homolog 1 isoform c 
COL17A1               0.008   alpha 1 type XVII collagen 
ARID1B                0.008   AT rich interactive domain 1B (SWI1-like) isoform 2 ...
MARCH9                0.008   membrane-associated RING-CH protein IX 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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