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Search of human proteins with 4506569
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506569 roundabout 1 isoform a [Homo sapiens]
(1651 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506569 roundabout 1 isoform a [Homo sapiens] 3365 0.0
gi|19743806 roundabout 1 isoform b [Homo sapiens] 3246 0.0
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 3236 0.0
gi|224994171 roundabout 1 isoform c [Homo sapiens] 3214 0.0
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 3080 0.0
gi|224994173 roundabout 1 isoform d [Homo sapiens] 3054 0.0
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 1397 0.0
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 1397 0.0
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 958 0.0
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 238 3e-62
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42... 229 1e-59
gi|157311649 neogenin homolog 1 [Homo sapiens] 223 1e-57
gi|118572606 hemicentin 1 [Homo sapiens] 221 5e-57
gi|7657359 contactin 5 isoform long [Homo sapiens] 219 2e-56
gi|28373129 contactin 5 isoform short [Homo sapiens] 219 2e-56
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 208 3e-53
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 208 4e-53
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 208 4e-53
gi|109150416 peroxidasin [Homo sapiens] 206 2e-52
gi|28373122 contactin 4 isoform a precursor [Homo sapiens] 205 3e-52
gi|222352127 sidekick 2 [Homo sapiens] 204 7e-52
gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo... 204 7e-52
gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo ... 204 7e-52
gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo s... 204 7e-52
gi|119220552 sidekick 1 [Homo sapiens] 203 1e-51
gi|75709184 contactin 3 [Homo sapiens] 202 2e-51
gi|110431348 deleted in colorectal carcinoma [Homo sapiens] 200 1e-50
gi|7657361 contactin 6 [Homo sapiens] 194 8e-49
gi|126517478 peroxidasin homolog-like [Homo sapiens] 193 1e-48
gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens] 192 2e-48
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 3365 bits (8724), Expect = 0.0
Identities = 1651/1651 (100%), Positives = 1651/1651 (100%)
Query: 1 MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSR 60
MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSR
Sbjct: 1 MKWKHVPFLVMISLLSLSPNHLFLAQLIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSR 60
Query: 61 LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 120
LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM
Sbjct: 61 LRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRM 120
Query: 121 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM 180
LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM
Sbjct: 121 LLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM 180
Query: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 240
VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC
Sbjct: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 240
Query: 241 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300
VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG
Sbjct: 241 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300
Query: 301 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360
ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360
Query: 361 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420
VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR
Sbjct: 361 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420
Query: 421 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG 480
SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG
Sbjct: 421 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATG 480
Query: 481 SPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYI 540
SPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYI
Sbjct: 481 SPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYI 540
Query: 541 EVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFS 600
EVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFS
Sbjct: 541 EVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFS 600
Query: 601 HASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPT 660
HASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPT
Sbjct: 601 HASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPT 660
Query: 661 SQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGE 720
SQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGE
Sbjct: 661 SQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGE 720
Query: 721 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 780
SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ
Sbjct: 721 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 780
Query: 781 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 840
GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP
Sbjct: 781 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 840
Query: 841 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFI 900
FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFI
Sbjct: 841 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAFI 900
Query: 901 AGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGG 960
AGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGG
Sbjct: 901 AGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVSSGG 960
Query: 961 RPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYN 1020
RPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYN
Sbjct: 961 RPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIANYN 1020
Query: 1021 NQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQ 1080
NQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQ
Sbjct: 1021 NQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATTQLIQ 1080
Query: 1081 SNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQ 1140
SNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQ
Sbjct: 1081 SNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTIPYNQ 1140
Query: 1141 SYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSE 1200
SYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSE
Sbjct: 1141 SYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPHSNSE 1200
Query: 1201 EYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1260
EYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST
Sbjct: 1201 EYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYSHQST 1260
Query: 1261 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVS 1320
ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVS
Sbjct: 1261 ATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISGPLVS 1320
Query: 1321 DMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEE 1380
DMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEE
Sbjct: 1321 DMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGSASEE 1380
Query: 1381 DNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRP 1440
DNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRP
Sbjct: 1381 DNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQCPRP 1440
Query: 1441 TSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQ 1500
TSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQ
Sbjct: 1441 TSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQSKTQ 1500
Query: 1501 LEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDG 1560
LEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDG
Sbjct: 1501 LEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQQNDG 1560
Query: 1561 KGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQA 1620
KGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQA
Sbjct: 1561 KGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQREQA 1620
Query: 1621 NVGRRNIAEMQVLGGYERGEDNNEELEETES 1651
NVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1621 NVGRRNIAEMQVLGGYERGEDNNEELEETES 1651
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 3246 bits (8416), Expect = 0.0
Identities = 1594/1595 (99%), Positives = 1595/1595 (100%)
Query: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
+GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 177 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 236
SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 237 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 297 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 356
KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 317
Query: 357 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 416
PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT
Sbjct: 318 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 377
Query: 417 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 476
NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC
Sbjct: 378 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 437
Query: 477 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 536
VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW
Sbjct: 438 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 497
Query: 537 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 596
SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII
Sbjct: 498 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 557
Query: 597 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQD 656
EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQD
Sbjct: 558 EAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQD 617
Query: 657 VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGA 716
VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGA
Sbjct: 618 VLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGA 677
Query: 717 NHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS 776
NHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS
Sbjct: 678 NHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPS 737
Query: 777 APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 836
APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS
Sbjct: 738 APPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 797
Query: 837 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 896
VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ
Sbjct: 798 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 857
Query: 897 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAV 956
PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAV
Sbjct: 858 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAV 917
Query: 957 SSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCI 1016
SSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCI
Sbjct: 918 SSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCI 977
Query: 1017 ANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATT 1076
ANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATT
Sbjct: 978 ANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYATT 1037
Query: 1077 QLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTI 1136
QLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTI
Sbjct: 1038 QLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPTI 1097
Query: 1137 PYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPH 1196
PYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPH
Sbjct: 1098 PYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHPPPH 1157
Query: 1197 SNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYS 1256
SNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYS
Sbjct: 1158 SNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAVSYS 1217
Query: 1257 HQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISG 1316
HQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISG
Sbjct: 1218 HQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGYISG 1277
Query: 1317 PLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGS 1376
PLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGS
Sbjct: 1278 PLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMINGWGS 1337
Query: 1377 ASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ 1436
ASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ
Sbjct: 1338 ASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFHASQ 1397
Query: 1437 CPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ 1496
CPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ
Sbjct: 1398 CPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSPTAQ 1457
Query: 1497 SKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQ 1556
SKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQ
Sbjct: 1458 SKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREAQEQ 1517
Query: 1557 QNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQ 1616
QNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQ
Sbjct: 1518 QNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSGSRQ 1577
Query: 1617 REQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1651
REQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1578 REQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1612
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 3236 bits (8389), Expect = 0.0
Identities = 1592/1598 (99%), Positives = 1593/1598 (99%), Gaps = 3/1598 (0%)
Query: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
+GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 177 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 236
SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 237 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 297 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ---EPPHF 353
KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ EPPHF
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Query: 354 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 413
VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL
Sbjct: 318 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 414 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 473
TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533
LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE
Sbjct: 438 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
Query: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 593
ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS
Sbjct: 498 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
Query: 594 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 653
YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK
Sbjct: 558 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Query: 654 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 713
TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP
Sbjct: 618 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
Query: 714 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 773
SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE
Sbjct: 678 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
Query: 774 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 833
APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS
Sbjct: 738 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 834 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 893
TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
Query: 894 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG 953
VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG
Sbjct: 858 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG 917
Query: 954 EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 1013
EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA
Sbjct: 918 EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 977
Query: 1014 DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY 1073
DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY
Sbjct: 978 DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY 1037
Query: 1074 ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1133
ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP
Sbjct: 1038 ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1097
Query: 1134 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1193
PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP
Sbjct: 1098 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1157
Query: 1194 PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV 1253
PPHSNSEEYNISVDESYDQEMPCPVPPAR YLQQDELEEEEDERGPTPPVRGAASSPAAV
Sbjct: 1158 PPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDERGPTPPVRGAASSPAAV 1217
Query: 1254 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1313
SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY
Sbjct: 1218 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1277
Query: 1314 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1373
ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING
Sbjct: 1278 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1337
Query: 1374 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1433
WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH
Sbjct: 1338 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1397
Query: 1434 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1493
ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP
Sbjct: 1398 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1457
Query: 1494 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA 1553
TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVL GRQVVDMRTNPGDPREA
Sbjct: 1458 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLGGRQVVDMRTNPGDPREA 1517
Query: 1554 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1613
QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG
Sbjct: 1518 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1577
Query: 1614 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1651
SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1578 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1615
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 3214 bits (8333), Expect = 0.0
Identities = 1585/1598 (99%), Positives = 1586/1598 (99%), Gaps = 12/1598 (0%)
Query: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
+GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 177 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 236
SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 237 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 297 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ---EPPHF 353
KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ EPPHF
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Query: 354 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 413
VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL
Sbjct: 318 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 414 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 473
TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533
LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE
Sbjct: 438 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
Query: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 593
ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS
Sbjct: 498 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
Query: 594 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 653
YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK
Sbjct: 558 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Query: 654 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 713
TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP
Sbjct: 618 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
Query: 714 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 773
SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE
Sbjct: 678 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
Query: 774 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 833
APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS
Sbjct: 738 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 834 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 893
TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
Query: 894 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG 953
VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKV TYQRGG
Sbjct: 858 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKV---------TYQRGG 908
Query: 954 EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 1013
EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA
Sbjct: 909 EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 968
Query: 1014 DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY 1073
DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY
Sbjct: 969 DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY 1028
Query: 1074 ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1133
ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP
Sbjct: 1029 ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1088
Query: 1134 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1193
PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP
Sbjct: 1089 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1148
Query: 1194 PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV 1253
PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV
Sbjct: 1149 PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV 1208
Query: 1254 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1313
SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY
Sbjct: 1209 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1268
Query: 1314 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1373
ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING
Sbjct: 1269 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1328
Query: 1374 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1433
WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH
Sbjct: 1329 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1388
Query: 1434 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1493
ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP
Sbjct: 1389 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1448
Query: 1494 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA 1553
TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA
Sbjct: 1449 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA 1508
Query: 1554 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1613
QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG
Sbjct: 1509 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1568
Query: 1614 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1651
SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1569 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1606
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 3080 bits (7984), Expect = 0.0
Identities = 1531/1598 (95%), Positives = 1533/1598 (95%), Gaps = 56/1598 (3%)
Query: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
+GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 177 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 236
SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 237 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 297 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ---EPPHF 353
KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ EPPHF
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Query: 354 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 413
VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL
Sbjct: 318 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 414 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 473
TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533
LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE
Sbjct: 438 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
Query: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 593
ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS
Sbjct: 498 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
Query: 594 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 653
YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK
Sbjct: 558 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Query: 654 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 713
TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP
Sbjct: 618 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
Query: 714 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 773
SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE
Sbjct: 678 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
Query: 774 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 833
APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS
Sbjct: 738 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 834 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 893
TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
Query: 894 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG 953
VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG
Sbjct: 858 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG 917
Query: 954 EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 1013
EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA
Sbjct: 918 EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 977
Query: 1014 DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY 1073
D + T Y L
Sbjct: 978 DW------------------QPTPYATTQL------------------------------ 989
Query: 1074 ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1133
IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP
Sbjct: 990 -----IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1044
Query: 1134 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1193
PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP
Sbjct: 1045 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1104
Query: 1194 PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV 1253
PPHSNSEEYNISVDESYDQEMPCPVPPAR YLQQDELEEEEDERGPTPPVRGAASSPAAV
Sbjct: 1105 PPHSNSEEYNISVDESYDQEMPCPVPPARTYLQQDELEEEEDERGPTPPVRGAASSPAAV 1164
Query: 1254 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1313
SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY
Sbjct: 1165 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1224
Query: 1314 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1373
ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING
Sbjct: 1225 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1284
Query: 1374 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1433
WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH
Sbjct: 1285 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1344
Query: 1434 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1493
ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP
Sbjct: 1345 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1404
Query: 1494 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA 1553
TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVL GRQVVDMRTNPGDPREA
Sbjct: 1405 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLGGRQVVDMRTNPGDPREA 1464
Query: 1554 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1613
QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG
Sbjct: 1465 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1524
Query: 1614 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1651
SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1525 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1562
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 3054 bits (7918), Expect = 0.0
Identities = 1522/1598 (95%), Positives = 1524/1598 (95%), Gaps = 67/1598 (4%)
Query: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
+GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 137
Query: 177 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 236
SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG
Sbjct: 138 SDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAG 197
Query: 237 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR
Sbjct: 198 KYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 257
Query: 297 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ---EPPHF 353
KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ EPPHF
Sbjct: 258 KDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQVGSEPPHF 317
Query: 354 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 413
VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL
Sbjct: 318 VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDL 377
Query: 414 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 473
TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV
Sbjct: 378 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV 437
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533
LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE
Sbjct: 438 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 497
Query: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 593
ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS
Sbjct: 498 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 557
Query: 594 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 653
YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK
Sbjct: 558 YIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 617
Query: 654 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 713
TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP
Sbjct: 618 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRP 677
Query: 714 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 773
SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE
Sbjct: 678 SGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEE 737
Query: 774 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 833
APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS
Sbjct: 738 APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGS 797
Query: 834 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 893
TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV
Sbjct: 798 TFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDV 857
Query: 894 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGG 953
VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRK VTYQRGG
Sbjct: 858 VKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRK---------VTYQRGG 908
Query: 954 EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPA 1013
EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRP
Sbjct: 909 EAVSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPG 968
Query: 1014 DCIANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPY 1073
+ T Y L
Sbjct: 969 --------------------QPTPYATTQL------------------------------ 978
Query: 1074 ATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1133
IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP
Sbjct: 979 -----IQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVP 1033
Query: 1134 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1193
PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP
Sbjct: 1034 PTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPPAHP 1093
Query: 1194 PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV 1253
PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV
Sbjct: 1094 PPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAAV 1153
Query: 1254 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1313
SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY
Sbjct: 1154 SYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYGY 1213
Query: 1314 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1373
ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING
Sbjct: 1214 ISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMING 1273
Query: 1374 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1433
WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH
Sbjct: 1274 WGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHFH 1333
Query: 1434 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1493
ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP
Sbjct: 1334 ASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKSP 1393
Query: 1494 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA 1553
TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA
Sbjct: 1394 TAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSSYKGREVLDGRQVVDMRTNPGDPREA 1453
Query: 1554 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1613
QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG
Sbjct: 1454 QEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYCRPTFPTSNNPRDPSSSSSMSSRGSG 1513
Query: 1614 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1651
SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES
Sbjct: 1514 SRQREQANVGRRNIAEMQVLGGYERGEDNNEELEETES 1551
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 1397 bits (3615), Expect = 0.0
Identities = 762/1462 (52%), Positives = 949/1462 (64%), Gaps = 170/1462 (11%)
Query: 58 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 117
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 37 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 96
Query: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 97 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 156
Query: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 157 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 216
Query: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 297
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 217 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 276
Query: 298 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 357
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FVV+P
Sbjct: 277 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 336
Query: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 417
RDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLTITN
Sbjct: 337 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 396
Query: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 477
+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L C
Sbjct: 397 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 456
Query: 478 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 537
ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE +WS
Sbjct: 457 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 516
Query: 538 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597
A ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++YIIE
Sbjct: 517 AVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIE 574
Query: 598 AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDV 657
AFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+TQD+
Sbjct: 575 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDI 634
Query: 658 LPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 717
P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 635 SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGL 694
Query: 718 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 777
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEAPSA
Sbjct: 695 QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSA 754
Query: 778 PPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 836
PPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD + S
Sbjct: 755 PPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRS 814
Query: 837 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 896
V+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DVVKQ
Sbjct: 815 VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQ 874
Query: 897 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRG-GEA 955
PAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG G
Sbjct: 875 PAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA-------------VTFQRGDGGL 920
Query: 956 VSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADC 1015
+S+G RPGLLN +P + PWLAD+WP T N NS N D
Sbjct: 921 MSNGSRPGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDV 969
Query: 1016 IANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYAT 1075
+ Q D +T ML + +Y +D + K ++NS + Q TPYAT
Sbjct: 970 LPPVPGQGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYAT 1015
Query: 1076 TQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPT 1135
TQ++ SN+++ + D + WK QQK ++ Y++ +QNK
Sbjct: 1016 TQILH---SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------- 1058
Query: 1136 IPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPP 1194
N GG KK + K K G WA++ LPPPP P
Sbjct: 1059 --------GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPL 1098
Query: 1195 PHSNSEEYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSP 1250
P + E Y + E+ YD + CP P + YL Q DEL EE+D+R PTPPVRG ASSP
Sbjct: 1099 PGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP 1157
Query: 1251 AAVSYSHQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSP 1298
A+S+ QSTATLTPSP+EE+QPMLQ D ++T H+Q QP P
Sbjct: 1158 -AISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQP 1212
Query: 1299 PPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASS 1358
P PP GY+SG L+SD++TD +D+AD E ++ R LR L+QTP SS
Sbjct: 1213 PVPP--------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSS 1260
Query: 1359 VGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKV 1418
+ +L+SSVTG SS R +S F TD++ + A++
Sbjct: 1261 MDNLDSSVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------- 1296
Query: 1419 ARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYT 1477
SQ PRPT K ++ QP RRE T
Sbjct: 1297 ---------------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMT 1326
Query: 1478 DDLPPPPVPPPAIKSPTAQSKT 1499
D+ P P+ SP S +
Sbjct: 1327 DEEALVPYSKPSFPSPGGHSSS 1348
Score = 90.1 bits (222), Expect = 2e-17
Identities = 62/201 (30%), Positives = 87/201 (43%), Gaps = 10/201 (4%)
Query: 337 GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 396
G+ + S PP V P D +V+ G T C+A G P P I W ++G +
Sbjct: 33 GQGQGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKD 92
Query: 397 QPPQSSSRFSVSQTGDLTITNVQRS--DVGYYICQTLNVAGSIITK-AYLEVTDVIADRP 453
P L I + +RS D G Y+C N G +++ A LEV + D
Sbjct: 93 DPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDD-- 150
Query: 454 PPVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQI 512
RQ P + VA +L C G P PTI W+KD V + ++ RI + G L I
Sbjct: 151 ---FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERI-SIRGGKLMI 206
Query: 513 RYAKLGDTGRYTCIASTPSGE 533
+ D G YTC+ + GE
Sbjct: 207 SNTRKSDAGMYTCVGTNMVGE 227
Score = 47.8 bits (112), Expect = 9e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1481 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1530
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1210 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1269
Query: 1531 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1582
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1270 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1329
Query: 1583 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1634
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1330 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1380
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 1397 bits (3615), Expect = 0.0
Identities = 762/1462 (52%), Positives = 949/1462 (64%), Gaps = 170/1462 (11%)
Query: 58 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 117
GSRLRQEDFPPRIVEHPSD+IVSKGEP TLNCKAEGRPTPTIEWYK GERVETDKDDPRS
Sbjct: 21 GSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNCKAEGRPTPTIEWYKDGERVETDKDDPRS 80
Query: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
HRMLLPSGSLFFLRIVHGR+S+PDEG YVCVARNYLGEAVS NASLEVA+LRDDFRQNP+
Sbjct: 81 HRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPT 140
Query: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237
DV+VA GEPA++ECQPPRGHPEPTI WKKD +DDK+ERI+IRGGKLMI+ TRKSDAG
Sbjct: 141 DVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKEERISIRGGKLMISNTRKSDAGM 200
Query: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 297
Y CVGTNMVGER+S+ AELTV ERP+F++RP N V +++ EF+C+ +GDP PTVRW+K
Sbjct: 201 YTCVGTNMVGERDSDPAELTVFERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKK 260
Query: 298 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 357
DD +LP+ RY+I+DD+TL+I+K + D G+Y C+AEN VGK EASATLTV+ PP FVV+P
Sbjct: 261 DDADLPRGRYDIKDDYTLRIKKTMSTDEGTYMCIAENRVGKMEASATLTVRAPPQFVVRP 320
Query: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 417
RDQ+VA GRTVTF CE GNPQPA+FW++EGSQNLLF QP Q +SR SVS TGDLTITN
Sbjct: 321 RDQIVAQGRTVTFPCETKGNPQPAVFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITN 380
Query: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 477
+QRSD GYYICQ L VAGSI+ KA LEVTDV+ DRPPP+I QGP NQT+AVDGT +L C
Sbjct: 381 IQRSDAGYYICQALTVAGSILAKAQLEVTDVLTDRPPPIILQGPANQTLAVDGTALLKCK 440
Query: 478 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 537
ATG P+P I W K+G +D R E G LQI+ ++ DTG YTC+A++ SGE +WS
Sbjct: 441 ATGDPLPVISWLKEGFTFPGRDPRATIQEQGTLQIKNLRISDTGTYTCVATSSSGETSWS 500
Query: 538 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597
A ++V E G + + D + +P PSKP+VTDV++N+VTLSWQP ++YIIE
Sbjct: 501 AVLDVTESGATIS--KNYDLSDLPGPPSKPQVTDVTKNSVTLSWQPGTPGTLPASAYIIE 558
Query: 598 AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDV 657
AFS + +SWQTVA +VKT ++GL+PN IYLF+VRA N G+SDPS +SDPV+TQD+
Sbjct: 559 AFSQSVSNSWQTVANHVKTTLYTVRGLRPNTIYLFMVRAINPQGLSDPSPMSDPVRTQDI 618
Query: 658 LPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 717
P +QGVDH+QVQ+ELG+ ++ LHNP VL+ ++++V WTVD+Q Q+IQGY+++YR +
Sbjct: 619 SPPAQGVDHRQVQKELGDVLVRLHNPVVLTPTTVQVTWTVDRQPQFIQGYRVMYRQTSGL 678
Query: 718 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 777
S W + + P + S V+ +L+KGV YEIK RP+FNEFQG DSE K +T EEAPSA
Sbjct: 679 QATSSWQNLDAKVPTERSAVLVNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSA 738
Query: 778 PPQGVTV-SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFS 836
PPQ VTV + N T+I VSW PPP D QNG++QEYK+WCLGNETR+HINKTVD + S
Sbjct: 739 PPQSVTVLTVGSYNSTSISVSWDPPPPDHQNGIIQEYKIWCLGNETRFHINKTVDAAIRS 798
Query: 837 VVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQ 896
V+I L PGI+Y VEVAAST AG GVKSEPQ I + V E+ S+ +QI+DVVKQ
Sbjct: 799 VIIGGLFPGIQYRVEVAASTSAGVGVKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQ 858
Query: 897 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRG-GEA 955
PAFIAGIG ACW+ILM FSIWLY RKKR GL S YA VT+QRG G
Sbjct: 859 PAFIAGIGGACWVILMGFSIWLYWRRKKRKGL-SNYA-------------VTFQRGDGGL 904
Query: 956 VSSGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADC 1015
+S+G RPGLLN +P + PWLAD+WP T N NS N D
Sbjct: 905 MSNGSRPGLLNAGDP-SYPWLADSWPATS----------LPVNNSNSGPNEIGNFGRGDV 953
Query: 1016 IANYNNQLDNKQTNLMLPESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQPTPYAT 1075
+ Q D +T ML + +Y +D + K ++NS + Q TPYAT
Sbjct: 954 LPPVPGQGD--KTATMLSDGAIYSSIDFTTK----TSYNSS--------SQITQATPYAT 999
Query: 1076 TQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPPT 1135
TQ++ SN+++ + D + WK QQK ++ Y++ +QNK
Sbjct: 1000 TQILH---SNSIHELAVDLPDPQWKSSIQQKTDLMGFGYSLPDQNK-------------- 1042
Query: 1136 IPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADL-LPPPPAHPP 1194
N GG KK + K K G WA++ LPPPP P
Sbjct: 1043 --------GNNGGKGGKK------------KKNKNSSKPQKNNGSTWANVPLPPPPVQPL 1082
Query: 1195 PHSNSEEYNISVDES-YDQEMPCPVPPARMYLQQ---DELEEEEDERGPTPPVRGAASSP 1250
P + E Y + E+ YD + CP P + YL Q DEL EE+D+R PTPPVRG ASSP
Sbjct: 1083 PGTELEHYAVEQQENGYDSDSWCPPLPVQTYLHQGLEDEL-EEDDDRVPTPPVRGVASSP 1141
Query: 1251 AAVSYSHQSTATLTPSPQEELQPMLQ------------DCPEETGHMQHQPDRRRQPVSP 1298
A+S+ QSTATLTPSP+EE+QPMLQ D ++T H+Q QP P
Sbjct: 1142 -AISFGQQSTATLTPSPREEMQPMLQAHLDELTRAYQFDIAKQTWHIQ----SNNQPPQP 1196
Query: 1299 PPPPRPISPPHTYGYISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASS 1358
P PP GY+SG L+SD++TD +D+AD E ++ R LR L+QTP SS
Sbjct: 1197 PVPP--------LGYVSGALISDLETDV---ADDDADDEEEALEIPR-PLRALDQTPGSS 1244
Query: 1359 VGDLESSVTGSMINGWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKV 1418
+ +L+SSVTG SS R +S F TD++ + A++
Sbjct: 1245 MDNLDSSVTGKAFT-----------SSQRPRPTS---PFSTDSNTSAALS---------- 1280
Query: 1419 ARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPG-HLRRETYT 1477
SQ PRPT K ++ QP RRE T
Sbjct: 1281 ---------------QSQRPRPT---------------KKHKGGRMDQQPALPHRREGMT 1310
Query: 1478 DDLPPPPVPPPAIKSPTAQSKT 1499
D+ P P+ SP S +
Sbjct: 1311 DEEALVPYSKPSFPSPGGHSSS 1332
Score = 47.8 bits (112), Expect = 9e-05
Identities = 45/174 (25%), Positives = 73/174 (41%), Gaps = 23/174 (13%)
Query: 1481 PPPPVPPPA---------IKSPTAQSKTQLEVRPVVVPK-LPSMDARTDRSSDRKGSSYK 1530
P PPVPP +++ A E + +P+ L ++D S D SS
Sbjct: 1194 PQPPVPPLGYVSGALISDLETDVADDDADDEEEALEIPRPLRALDQTPGSSMDNLDSSVT 1253
Query: 1531 GREVLDG---RQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTH-----LIQE 1582
G+ R T+ + Q + +K + D PA H +E
Sbjct: 1254 GKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKKHKGGRMDQQPALPHRREGMTDEE 1313
Query: 1583 DILPYCRPTFPTSNNPRDPSSSSSMSSRGS-GSRQREQANVG-RRNIAEMQVLG 1634
++PY +P+FP +P SSS + SS+GS G R+ E G +RN +++ +G
Sbjct: 1314 ALVPYSKPSFP---SPGGHSSSGTASSKGSTGPRKTEVLRAGHQRNASDLLDIG 1364
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 958 bits (2477), Expect = 0.0
Identities = 550/1251 (43%), Positives = 741/1251 (59%), Gaps = 124/1251 (9%)
Query: 58 GSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 117
GSR+ ED PRIVE P DL+VS+GEPATL C+AEGRP P IEWYK G RV T ++DPR+
Sbjct: 54 GSRVGPEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRPRPNIEWYKNGARVATVREDPRA 113
Query: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
HR+LLPSG+LFF RIVHGR++RPDEGVY CVARNYLG A S NASLEVA+LRDDFRQ+P
Sbjct: 114 HRLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPG 173
Query: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237
+V+VAVGEPAV+EC PPRGHPEP++SW+KDG+ L +++ RITIRGGKLM+++T KSDAG
Sbjct: 174 NVVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGRITIRGGKLMMSHTLKSDAGM 233
Query: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 297
YVCV +NM GERES AE+ VLERPSF++RP N V D F CE +GDP P +RWRK
Sbjct: 234 YVCVASNMAGERESAAAEVMVLERPSFLRRPVNQVVLADAPVTFLCEVKGDPPPRLRWRK 293
Query: 298 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 357
+DGELP RYEIR DH+L I V+A D G+YTCVAEN VG+AEAS +L+V PP V +P
Sbjct: 294 EDGELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEASGSLSVHVPPQLVTQP 353
Query: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 417
+DQ+ A G +V FQCE GNP PAIFW++EGSQ LLF Q Q + RFSVS G L IT
Sbjct: 354 QDQMAAPGESVAFQCETKGNPPPAIFWQKEGSQVLLFPSQSLQPTGRFSVSPRGQLNITA 413
Query: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCV 477
VQR D GYY+CQ ++VAGSI+ KA LE+ D PPVI QGP NQT+ + + L C
Sbjct: 414 VQRGDAGYYVCQAVSVAGSILAKALLEIKGASLDGLPPVILQGPANQTLVLGSSVWLPCR 473
Query: 478 ATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWS 537
TG+P P++ W+KDG + D + K + NG L I + D G Y+C+A + +GEATWS
Sbjct: 474 VTGNPQPSVRWKKDGQWLQGDDLQFKTMANGTLYIANVQEMDMGFYSCVAKSSTGEATWS 533
Query: 538 AYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597
+++++E V P PT+P+ P APS+P VT++++N++TL+W+PN +GA TSY+IE
Sbjct: 534 GWLKMRE-DWGVSPDPPTEPSSPPGAPSQPVVTEITKNSITLTWKPNPQTGAAVTSYVIE 592
Query: 598 AFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDV 657
AFS A+G++W+TVA+ V+ ET + GL+PN IYLFLVRA A+G+S+PS +S+PV+TQD
Sbjct: 593 AFSPAAGNTWRTVADGVQLETHTVSGLQPNTIYLFLVRAVGAWGLSEPSPVSEPVRTQDS 652
Query: 658 LPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 717
P+ D + Q+ L + L P VL +++V WTVD Q +QG+++ +R +G
Sbjct: 653 SPSRPVEDPWRGQQGLAEVAVRLQEPIVLGPRTLQVSWTVDGPVQLVQGFRVSWRVAGPE 712
Query: 718 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 777
G W + ++++P++ S V+ L G +IK + E GA+S EEAPS
Sbjct: 713 GG--SWTMLDLQSPSQQSTVLRGLPPGTQIQIKVQAQGQEGLGAESLSVTRSIPEEAPSG 770
Query: 778 PPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSV 837
PPQGV V+ ++I VSW+PP QNG++ EY++WCLGNE+R+H+N++ G S
Sbjct: 771 PPQGVAVALGGDGNSSITVSWEPPLPSQQNGVITEYQIWCLGNESRFHLNRSAAGWARSA 830
Query: 838 VIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP--EDQVSLAQQISDVVK 895
++ LVPG+ Y VAA+T AG GV S P +QL + + + P E LA +++ V++
Sbjct: 831 MLRGLVPGLLYRTLVAAATSAGVGVPSAPVLVQLPSPPD-LEPGLEVGAGLAVRLARVLR 889
Query: 896 QPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEA 955
+PAF+AG GAAC +L+ LY RK+R L+ A SF +TP V++
Sbjct: 890 EPAFLAGSGAACGALLLGLCAALYWRRKQRKELSHYTA------SFAYTPAVSFPHSEGL 943
Query: 956 VSSGGRP--GLLNISEPAAQPWLADTWPNTGNNHN--DCSISCCTAGNGNSDSNLTTYSR 1011
+ RP GL PA WLAD+WP+ + + + SCC + N D + Y+
Sbjct: 944 SGASSRPPMGL----GPAPYSWLADSWPHPSRSPSAQEPRGSCCPS---NPDPDDRYYNE 996
Query: 1012 PADCIANYNNQLDNKQTNLMLP-ESTVYGDVDLSNKINEMKTFNSPNLKDGRFVNPSGQP 1070
A + L P E VY +D + + E++TF+ G +PSG
Sbjct: 997 -----AGISLYLAQTARGTAAPGEGPVYSTIDPAGE--ELQTFHG-----GFPQHPSGDL 1044
Query: 1071 TPYATTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRAND 1130
P+ +Q S GDSG K G+ K PVQ LN +
Sbjct: 1045 GPW--SQYAPPEWS------QGDSGAKG----GKVKLLGKPVQ-----MPSLNWP----E 1083
Query: 1131 TVPPTIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP 1190
+PP P S S G + +G+ P+ W +P
Sbjct: 1084 ALPPPPP---------------SCELSCLEGPEEELEGSSEPE-------EWCPPMPERS 1121
Query: 1191 AHPPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSP 1250
P S+ C V P+R + PTP
Sbjct: 1122 HLTEPSSSG---------------GCLVTPSR-----------RETPSPTP--------- 1146
Query: 1251 AAVSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPP 1301
SY QSTATLTPSP + QP P + H+ P RR P+ P P
Sbjct: 1147 ---SYGQQSTATLTPSPPDPPQP-----PTDMPHLHQMP--RRVPLGPSSP 1187
Score = 42.0 bits (97), Expect = 0.005
Identities = 61/223 (27%), Positives = 86/223 (38%), Gaps = 65/223 (29%)
Query: 1415 GLKVARRQMQDAAGRRHFHASQCPRPTSPVSTDSNMSAAVMQKTRPAK----KLKHQPGH 1470
G++ AR A H S P P++ S + T P + + + +P
Sbjct: 1196 GIREARPAGLGAGPAASPHLSPSPAPSTASSAPGRTWQGNGEMTPPLQGPRARFRKKPKA 1255
Query: 1471 L--RRETYTDDLPPPPVPPPAIKSPTAQSKTQLEVRPVVVPKLPSMDARTDRSSDRKGSS 1528
L RRE DLPPPP+PPP ++ A LE+R + S++ +RS +RK
Sbjct: 1256 LPYRRENSPGDLPPPPLPPPEEEASWA-----LELR--AAGSMSSLER--ERSGERKAV- 1305
Query: 1529 YKGREVLDGRQVVDMRTNPGDPREAQEQQNDGKGRGNKAAKRDLPPAKTHLIQEDILPYC 1588
Q V + AA+R L P +E LPY
Sbjct: 1306 ----------QAVPL-----------------------AAQRVLHPD-----EEAWLPYS 1327
Query: 1589 RPTF----------PTSNNPRDPSSSSSMSSRGSG-SRQREQA 1620
RP+F T+ + SSSS SRG G SR R Q+
Sbjct: 1328 RPSFLSRGQGTSTCSTAGSNSSRGSSSSRGSRGPGRSRSRSQS 1370
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 238 bits (608), Expect = 3e-62
Identities = 228/907 (25%), Positives = 373/907 (41%), Gaps = 97/907 (10%)
Query: 27 LIPDPEDVERGNDHGTPIPTSDNDDNSLGYTGSRLRQ------------EDFPPRIVEHP 74
++PD RG + T + TS +S Y R+ ED PRIV
Sbjct: 415 VLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSF 474
Query: 75 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134
S+ +V+ GE +L C A+G P PT+ W E + D R+++ + G+ V
Sbjct: 475 SEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH-RTNQYTMSDGTTISHMNVT 533
Query: 135 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS-----DVMVAVGEPAVM 189
G + R D GVY C ARN +G A + A + V R PS ++ G ++
Sbjct: 534 GPQIR-DGGVYRCTARNLVGSA-EYQARINV-------RGPPSIRAMRNITAVAGRDTLI 584
Query: 190 ECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS-DAGKYVCVGTNMVGE 248
C+ G+P +I W KD L D ++ G L +T +K D G+Y+C
Sbjct: 585 NCRVI-GYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQL 643
Query: 249 RESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT-VRWRKDDGELPKSRY 307
S+ + V + P ++ ++ C +P + WRKD G++ S
Sbjct: 644 SISQSVHVAV-KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKD-GQVIISGS 701
Query: 308 EIRDDH-----TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 362
+ + +L+I V+ G+YTC+A N L V+ PP FVV+P +Q
Sbjct: 702 GVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDG 761
Query: 363 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 422
G+ C G P P + W+ Y P + R + L I +V D
Sbjct: 762 IYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEED 821
Query: 423 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGS 481
+GYY+CQ N G+ I+K+ + P +I P N T+A+ G L+C A G
Sbjct: 822 IGYYLCQASNGVGTDISKSMFLTVKI-----PAMITSHP-NTTIAIKGHAKELNCTARGE 875
Query: 482 PVPTILWRKDGVLVS---TQDSRIKQLENG-----VLQIRYAKLGDTGRYTCIASTPSGE 533
I W K ++ I +NG L+++ A GD+ ++C A GE
Sbjct: 876 RPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGE 935
Query: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTS 593
+ VQE P P + E+ +V ++ L W + + T
Sbjct: 936 DRGLIQLTVQE----------------PPDPPELEIREVKARSMNLRWTQRFDGNSIITG 979
Query: 594 YIIEAFSHASGSSWQTVAENVK--TETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDP 651
+ IE + + ++ N+ + I L P ++Y + + N G S+PS+
Sbjct: 980 FDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSK-ELT 1038
Query: 652 VKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQGYK 708
+ T++ P +D ++S SI+V W + Q+ I+GY+
Sbjct: 1039 ISTEEAAPDGPPMD---------------VTLQPVTSQSIQVTWKAPKKELQNGVIRGYQ 1083
Query: 709 ILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARPFFNEFQGADSEIKF 767
I YR + + + E++ + V + +L+K Y + + F G S
Sbjct: 1084 IGYRENSPG-SNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEIN 1142
Query: 768 AKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYH 825
A TLE+ PS PP+ V + ++SW PP T NG+++ Y+V W L + +
Sbjct: 1143 ATTLEDVPSQPPENVRALSITSD--VAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWG 1200
Query: 826 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL--DAHGNPVSPEDQ 883
+ + + V + + YSV+V A T AG GV+S +IQ D G P +
Sbjct: 1201 EMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV 1260
Query: 884 VSLAQQI 890
S A +
Sbjct: 1261 PSSASSV 1267
Score = 144 bits (362), Expect = 9e-34
Identities = 145/488 (29%), Positives = 205/488 (42%), Gaps = 68/488 (13%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
P I++ V G L C A G P P I W K G LP+ S
Sbjct: 286 PTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRP--------------LPADSR 331
Query: 128 FFLRIVHGRKS---RPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
+ RI S D G Y+C N G A + + + L P + +G
Sbjct: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--VTLTPKKLKTGIG 389
Query: 185 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG---GKLMITYTRKSDAGKYVCV 241
++ C G PE TI W ++ + L DE I+IRG L+IT +KS +G Y C
Sbjct: 390 STVILSC-ALTGSPEFTIRWYRN-TELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCF 447
Query: 242 GTNMVGERESEVAE---LTVLE--RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
T R+++ A+ + LE P V S V + C A+G P PTV W
Sbjct: 448 AT-----RKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
Query: 297 KD------DGELPKSRYEIRDDHTLKIRKVTA---GDMGSYTCVAENMVGKAEASATLTV 347
D DG ++Y + D T+ VT D G Y C A N+VG AE A + V
Sbjct: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINV 562
Query: 348 QEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSV 407
+ PP + R+ GR C G P +I W ++ LL + R V
Sbjct: 563 RGPPS-IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDA---LLL-----PDNHRQVV 613
Query: 408 SQTGDLTITNVQRS-DVGYYICQTLNVAGSIITKAYLEVTDV--IADRPPPVIRQGPVNQ 464
+ G L +T+VQ+ D G Y+C S++ + L ++ +A + PP+I+ P
Sbjct: 614 FENGTLKLTDVQKGMDEGEYLC-------SVLIQPQLSISQSVHVAVKVPPLIQ--PFEF 664
Query: 465 TVAVDGTFV-LSCVATGSPVP-TILWRKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDT 520
A G + + CV + +P I WRKDG V++S I+ E LQI L
Sbjct: 665 PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHN 724
Query: 521 GRYTCIAS 528
G YTCIAS
Sbjct: 725 GNYTCIAS 732
Score = 135 bits (340), Expect = 3e-31
Identities = 235/1024 (22%), Positives = 377/1024 (36%), Gaps = 133/1024 (12%)
Query: 36 RGNDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRP 95
R D GT I N S TG + + P + P L G L+C G P
Sbjct: 345 RTEDSGTYICEVTNTFGSAEATGILMVID--PLHVTLTPKKLKTGIGSTVILSCALTGSP 402
Query: 96 TPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE 155
TI WY+ E V D+ + + S L I +KS G Y C A
Sbjct: 403 EFTIRWYRNTELVLPDE------AISIRGLSNETLLITSAQKSH--SGAYQCFATRKAQT 454
Query: 156 AVSHNASLEVAILRDD---FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL- 211
A + L D + S+ +V GE + C +G P PT++W D P+
Sbjct: 455 A----QDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMC-AAKGAPPPTVTWALDDEPIV 509
Query: 212 ---DDKDERITIRGG----KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF 264
+ + T+ G + +T + D G Y C N+VG E + A + V PS
Sbjct: 510 RDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQ-ARINVRGPPS- 567
Query: 265 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAG 323
++ N+ C G P +++W KD LP + R + ++ TLK+ V G
Sbjct: 568 IRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKG 627
Query: 324 -DMGSYTC-VAENMVGKAEASATLTVQEPPHFVVKPRD-QVVALGRTVTFQCEATGNPQP 380
D G Y C V S + V+ PP +++P + ++G+ + C + P
Sbjct: 628 MDEGEYLCSVLIQPQLSISQSVHVAVKVPP--LIQPFEFPPASIGQLLYIPCVVSSGDMP 685
Query: 381 -AIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIIT 439
I WR++G + S +S S L I++V G Y C N A ++
Sbjct: 686 IRITWRKDGQVIISGSGVTIESKEFMS-----SLQISSVSLKHNGNYTCIASNAAATVSR 740
Query: 440 KAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQD 499
+ L V R PP P NQ VL+C G P P ++W+ + Q
Sbjct: 741 ERQLIV------RVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQ 794
Query: 500 -------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG-EATWSAYIEVQEFGVPVQ- 550
RI+ L N L IR+ D G Y C AS G + + S ++ V+ +P
Sbjct: 795 YHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK---IPAMI 851
Query: 551 PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 610
P I + T + + W+ ++ P + ++ A+ + V
Sbjct: 852 TSHPNTTIAIKGHAKELNCTARGERPIIIRWEKG-DTVIDPDR--VMRYAIATKDNGDEV 908
Query: 611 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 670
+K +K F A N+YG +G+ VQ
Sbjct: 909 VSTLK-----LKPADRGDSVFFSCHAINSYG------------------EDRGLIQLTVQ 945
Query: 671 RELGNAVLHLHNPTVLSSSSIEVHWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVR 729
L + + + S+ + WT + I G+ I Y+ +SD F+
Sbjct: 946 EPPDPPELEIRE---VKARSMNLRWTQRFDGNSIITGFDIEYK------NKSDSWDFKQS 996
Query: 730 T----PAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVS 785
T P N I DL Y I+ F + S+ T E AP PP VT+
Sbjct: 997 TRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTL- 1055
Query: 786 KNDGNGTAILVSWQPPPEDTQNGMVQEYKVW----CLGNETRYHI-NKTVDGSTFSVVIP 840
+I V+W+ P ++ QNG+++ Y++ G+ +Y I G + +
Sbjct: 1056 -QPVTSQSIQVTWKAPKKELQNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLD 1114
Query: 841 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVV----KQ 896
L +Y V V A AG+G S + P P + V SDV +
Sbjct: 1115 NLKKFAQYGVVVQAFNRAGTG-PSSSEINATTLEDVPSQPPENVRALSITSDVAVISWSE 1173
Query: 897 PAFIAGIGAACWIILMVFSIWLYRHRKKRNGLTST-----YAGIRKVPSFTFTPTVTYQR 951
P G ++ +S+++ + +T+T G+ K +++ + Y +
Sbjct: 1174 PPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYS-VQVLAYTQ 1232
Query: 952 GGEAVSS------------GGRPGLLNISEPAAQ---PWLADTWPNTGNNHNDCSISCCT 996
G+ V S G G+ + A+ WL T PN +I C +
Sbjct: 1233 AGDGVRSSVLYIQTKEDVPGPPAGIKAVPSSASSVVVSWLPPTKPN--GVIRKYTIFCSS 1290
Query: 997 AGNG 1000
G+G
Sbjct: 1291 PGSG 1294
Score = 132 bits (331), Expect = 4e-30
Identities = 186/833 (22%), Positives = 322/833 (38%), Gaps = 112/833 (13%)
Query: 82 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL-PSGSLFFLRIVHGRKSRP 140
G +NC+ G P +I+WYK + P +HR ++ +G+L + G
Sbjct: 579 GRDTLINCRVIGYPYYSIKWYKDALLL------PDNHRQVVFENGTLKLTDVQKGM---- 628
Query: 141 DEGVYVC--VARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 198
DEG Y+C + + L + S + +++V L F P+ ++G+ + C G
Sbjct: 629 DEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPA----SIGQLLYIPCVVSSGDM 684
Query: 199 EPTISWKKDGSPLDDKDERITIRGGKLM----ITYTRKSDAGKYVCVGTNMVGERESEVA 254
I+W+KDG + +TI + M I+ G Y C+ +N E
Sbjct: 685 PIRITWRKDGQVIIS-GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRE-R 742
Query: 255 ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY------- 307
+L V P FV +P+N + C G P P V W+ G +Y
Sbjct: 743 QLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTG 802
Query: 308 --EIRDDHTLKIRKVTAGDMGSYTCVAENMVGK-AEASATLTVQEPPHFVVKPRDQVVAL 364
+I + +L IR V D+G Y C A N VG S LTV+ P P +
Sbjct: 803 RIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK 862
Query: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS--QTGDLTITNVQ--- 419
G C A G I W + + P R++++ GD ++ ++
Sbjct: 863 GHAKELNCTARGERPIIIRWEKGDT------VIDPDRVMRYAIATKDNGDEVVSTLKLKP 916
Query: 420 --RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV------IRQGPVNQTVAVDGT 471
R D ++ C +N G + +++T PP + R + T DG
Sbjct: 917 ADRGDSVFFSCHAINSYGE--DRGLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGN 974
Query: 472 FVLSCVATGSPVPTILW----RKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCI 526
+++ + W + + + I L V IR GR
Sbjct: 975 SIITGFDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGR---- 1030
Query: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP--- 583
S PS E T S E P PP D L P V+ ++ ++W+
Sbjct: 1031 -SEPSKELTIST-----EEAAPDGPPM--DVTLQP----------VTSQSIQVTWKAPKK 1072
Query: 584 NLNSGATPTSYIIEAFSHASGSSWQTVAENVK----TETSAIKGLKPNAIYLFLVRAANA 639
L +G Y I ++ GS+ Q +K +E + LK A Y +V+A N
Sbjct: 1073 ELQNGVI-RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNR 1131
Query: 640 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 699
G S + +DV P+ + + + AV+ P + + +
Sbjct: 1132 AGTGPSSSEINATTLEDV-PSQPPENVRALSITSDVAVISWSEPPRSTLNGV-------- 1182
Query: 700 QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQ 759
++GY++++ + + + +W + T + V + + K NY ++ +
Sbjct: 1183 ----LKGYRVIF---WSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGD 1235
Query: 760 GADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLG 819
G S + + +T E+ P PP G+ + + ++++VSW PP + NG++++Y ++C
Sbjct: 1236 GVRSSVLYIQTKEDVPG-PPAGIKAVPS--SASSVVVSWLPPTKP--NGVIRKYTIFCSS 1290
Query: 820 NETRYHINKTVDGSTFSVV--IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQ 870
+ + S + I L G +Y + VAA T AG G SE I+
Sbjct: 1291 PGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIE 1343
Score = 131 bits (330), Expect = 5e-30
Identities = 133/477 (27%), Positives = 193/477 (40%), Gaps = 42/477 (8%)
Query: 89 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHR----MLLPSGSLFFLRIVHGRKSRPDEG 143
C A G P+ + WY G+ + H L P F +H +
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIH-------DN 159
Query: 144 VYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE--PT 201
Y C A N G+ S N ++ A+ R+ + D G AV +C P E
Sbjct: 160 DYFCTAENAAGKIRSPNIRVK-AVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Query: 202 ISWKKDG-SPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNMV-GE-RESEVAELT 257
+SW+KD S + + IT GG L I+ +K DA Y C+ + GE R+S A L+
Sbjct: 219 VSWEKDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
Query: 258 VLER----PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDH 313
V + P+ + + V + E C A G P+P +RW KD LP +
Sbjct: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
Query: 314 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 373
L I + D G+Y C N G AEA+ L V +P H + P+ +G TV C
Sbjct: 338 GLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVILSCA 397
Query: 374 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 433
TG+P+ I W R L P ++ S +S L IT+ Q+S G Y C
Sbjct: 398 LTGSPEFTIRWYRNTELVL-----PDEAISIRGLSNE-TLLITSAQKSHSGAYQCFATRK 451
Query: 434 AGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR-KDG 492
A + A + + D P I + V F L C A G+P PT+ W D
Sbjct: 452 AQTAQDFAIIALED-----GTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDE 506
Query: 493 VLVSTQDSRIKQ--LENGV----LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
+V R Q + +G + + ++ D G Y C A G A + A I V+
Sbjct: 507 PIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
Score = 102 bits (253), Expect = 4e-21
Identities = 93/324 (28%), Positives = 140/324 (43%), Gaps = 29/324 (8%)
Query: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKC---EARGDPVPTVR 294
Y C N G+ S + + R + R + + A FKC + + V V
Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Query: 295 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGD-MGSYTCVAENMVG---KAEASATLTVQE 349
W KD + P+ R+ I L I V D + +Y C+ ++ + A L+V +
Sbjct: 221 WEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTD 280
Query: 350 PPHFVVKPRD----QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 405
P + D Q V G TV C A+G P PAI W ++G +P + SR+
Sbjct: 281 PAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDG--------RPLPADSRW 332
Query: 406 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT 465
+ TG LTI++++ D G YIC+ N GS L V D P + P
Sbjct: 333 TKRITG-LTISDLRTEDSGTYICEVTNTFGSAEATGILMVID------PLHVTLTPKKLK 385
Query: 466 VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYT 524
+ T +LSC TGSP TI W ++ LV ++ I+ L N L I A+ +G Y
Sbjct: 386 TGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQ 445
Query: 525 CIASTPSGEATWSAYIEVQEFGVP 548
C A+ + A A I +++ G P
Sbjct: 446 CFATRKAQTAQDFAIIALED-GTP 468
Score = 69.3 bits (168), Expect = 3e-11
Identities = 76/310 (24%), Positives = 121/310 (39%), Gaps = 44/310 (14%)
Query: 474 LSCVATGSPVPTILWRKDG----VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 529
L C + G P P + W KD + VS R+ NG L +R K D+G YTC A+
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHT-NGTLLLRAVKAEDSGYYTCTATN 1427
Query: 530 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 589
G T + VQ VP PR T V+ S +++TL+W P N G+
Sbjct: 1428 TGGFDTIIVNLLVQ---VPPDQPRLT-------------VSKTSASSITLTWIPGDNGGS 1471
Query: 590 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 649
+ ++++ +S + W+ V + + + LK Y + A N+ G S+I
Sbjct: 1472 SIRGFVLQ-YSVDNSEEWKDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRISEII 1530
Query: 650 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 709
+ KT P+ H +A L+L W + I +
Sbjct: 1531 E-AKTHGREPSFSKDQHLFTHINSTHARLNLQG------------W--NNGGCPITAIVL 1575
Query: 710 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 769
YRP G W +R + V + +LR+ YE++ R N + +FA
Sbjct: 1576 EYRPKGT------WAWQGLRANSSGEVFLTELREATWYELRMRA-CNSAGCGNETAQFAT 1628
Query: 770 TLEEAPSAPP 779
+ + PP
Sbjct: 1629 LDYDGSTIPP 1638
Score = 50.8 bits (120), Expect = 1e-05
Identities = 32/74 (43%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 283 CEARGDPVPTVRWRKD--DGELPKSRYEIRDDHT---LKIRKVTAGDMGSYTCVAENMVG 337
C + GDP P V+W KD D +P S R HT L +R V A D G YTC A N G
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
Query: 338 KAEASATLTVQEPP 351
L VQ PP
Sbjct: 1431 FDTIIVNLLVQVPP 1444
Score = 45.8 bits (107), Expect = 3e-04
Identities = 72/359 (20%), Positives = 127/359 (35%), Gaps = 51/359 (14%)
Query: 300 GELPKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
G+ S YE + +I + G A G+ +S +T++ K
Sbjct: 1294 GQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAG----KAP 1349
Query: 359 DQVVALGRTVT--------FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
++++ G TVT C + G+P PA+ W ++ + + P +
Sbjct: 1350 AKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAI----PVSMDGHRLIHTN 1405
Query: 411 GDLTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468
G L + V+ D GYY C N G +II ++V D+P + + +
Sbjct: 1406 GTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLLVQVP---PDQPRLTVSKTSASSITLT 1462
Query: 469 ------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGR 522
G+ + V S + W+ V +S+ + K + K G +
Sbjct: 1463 WIPGDNGGSSIRGFVLQYSVDNSEEWK--DVFISSSERSFK--------LDSLKCGTWYK 1512
Query: 523 YTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 582
A G S IE + G +P D +L T ++ L+ Q
Sbjct: 1513 VKLAAKNSVGSGRISEIIEAKTHG--REPSFSKDQHLF---------THINSTHARLNLQ 1561
Query: 583 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 641
N+G P + I+ + +WQ + N E + L+ Y +RA N+ G
Sbjct: 1562 -GWNNGGCPITAIVLEYRPKGTWAWQGLRANSSGEV-FLTELREATWYELRMRACNSAG 1618
Score = 37.0 bits (84), Expect = 0.16
Identities = 34/157 (21%), Positives = 58/157 (36%), Gaps = 14/157 (8%)
Query: 196 GHPEPTISWKKDGS----PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
G P P + W KD P+ R+ G L++ + D+G Y C TN G ++
Sbjct: 1375 GDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN-TGGFDT 1433
Query: 252 EVAELTVLERPSFVK------RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
+ L V P + S++ +T RG +++ D+ E K
Sbjct: 1434 IIVNLLVQVPPDQPRLTVSKTSASSITLTWIPGDNGGSSIRGF---VLQYSVDNSEEWKD 1490
Query: 306 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 342
+ + + K+ + G A+N VG S
Sbjct: 1491 VFISSSERSFKLDSLKCGTWYKVKLAAKNSVGSGRIS 1527
Score = 34.7 bits (78), Expect = 0.79
Identities = 26/88 (29%), Positives = 37/88 (42%), Gaps = 12/88 (13%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLP 123
P +I+ + + L C + G P P ++W K E D P S HR++
Sbjct: 1349 PAKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDSE----DSAIPVSMDGHRLIHT 1404
Query: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARN 151
+G+L LR V D G Y C A N
Sbjct: 1405 NGTL-LLRAVKAE----DSGYYTCTATN 1427
>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
precursor [Homo sapiens]
Length = 2012
Score = 229 bits (585), Expect = 1e-59
Identities = 261/981 (26%), Positives = 401/981 (40%), Gaps = 143/981 (14%)
Query: 64 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDP----RSHR 119
ED P+I+ S+ +VS EP +L C +G P PTI W T DDP SHR
Sbjct: 403 EDGTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITW--------TLDDDPILKGGSHR 454
Query: 120 ---MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
M+ G++ + + R D GVY C A N G V + A + V R P
Sbjct: 455 ISQMITSEGNVVSYLNISSSQVR-DGGVYRCTANNSAG-VVLYQARINV---RGPASIRP 509
Query: 177 SDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKS- 233
+ A+ G + C+ G+P +I W K+ + L ++ G L ++ +K
Sbjct: 510 MKNITAIAGRDTYIHCRVI-GYPYYSIKWYKNSNLLPFNHRQVAFENNGTLKLSDVQKEV 568
Query: 234 DAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-T 292
D G+Y C S+ +TV + P F++ ++ C +P T
Sbjct: 569 DEGEYTCNVLVQPQLSTSQSVHVTV-KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPIT 627
Query: 293 VRWRKDDGELPKSRYEIRDD----HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348
+ W+KD +P S D+ +L+I ++ G+YTC+A N E + L V+
Sbjct: 628 ITWQKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVR 687
Query: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
PP FVV+PRDQ G+ V C A G P P I W+ + +QP + R V
Sbjct: 688 VPPKFVVQPRDQDGIYGKAVILNCSAEGYPVPTIVWKFSKGAGVP-QFQPIALNGRIQVL 746
Query: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKA-YLEVTDVIADRPPPVIRQGPVNQTVA 467
G L I +V D GYY+C+ N G+ ++K+ YL V + P +I P N T+A
Sbjct: 747 SNGSLLIKHVVEEDSGYYLCKVSNDVGADVSKSMYLTV------KIPAMITSYP-NTTLA 799
Query: 468 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSR--IKQLENG-----VLQIRYAKLGD 519
G +SC A G + W K+ +++ + +R + E G LQI D
Sbjct: 800 TQGQKKEMSCTAHGEKPIIVRWEKEDRIINPEMARYLVSTKEVGEEVISTLQILPTVRED 859
Query: 520 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 579
+G ++C A GE + VQE P P + E+ DV T+TL
Sbjct: 860 SGFFSCHAINSYGEDRGIIQLTVQE----------------PPDPPEIEIKDVKARTITL 903
Query: 580 SWQPNLNSGATPTSYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLVRAA 637
W + + T Y IE + + S+ +T + + ++ I + P++ Y + A
Sbjct: 904 RWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSPQLNSATIIDIHPSSTYSIRMYAK 963
Query: 638 NAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV 697
N G S+PS + + P + +HL +SS SI V W
Sbjct: 964 NRIGKSEPSN-ELTITADEAAPDGPPQE------------VHLE---PISSQSIRVTWKA 1007
Query: 698 DQ---QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV-VIPDLRKGVNYEIKARP 753
+ Q+ I+GY+I YR G + + V T + V + +L K Y + +
Sbjct: 1008 PKKHLQNGIIRGYQIGYREYSTG-GNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQA 1066
Query: 754 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 813
G S+ TLE+ PS PP+ V + +I +SW ++ NG++Q +
Sbjct: 1067 CNRAGTGPSSQEIITTTLEDVPSYPPENVQAIAT--SPESISISWSTLSKEALNGILQGF 1124
Query: 814 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 871
+V W + K + + S+ + L YS++V A T AG GV+SE F +
Sbjct: 1125 RVIYWANLMDGELGEIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRT 1184
Query: 872 --DAHGNPVSPEDQVSLAQQISDVVKQPAFIAGIGAACWIILMVFSIWLYRHRKKRNGLT 929
D G P AG+ AA MVF WL K NG+
Sbjct: 1185 KEDVPGPP-----------------------AGVKAAAASASMVFVSWL--PPLKLNGI- 1218
Query: 930 STYAGIRKVPSFTFTPTVTYQRGGEAVSSGGRPGLLNISEPAAQP-WLADTWPNTGNN-- 986
IRK F P T ISE A P + PN N
Sbjct: 1219 -----IRKYTVFCSHPYPTV-----------------ISEFEASPDSFSYRIPNLSRNRQ 1256
Query: 987 HNDCSISCCTAGNGNSDSNLT 1007
++ ++ +AG GNS +T
Sbjct: 1257 YSVWVVAVTSAGRGNSSEIIT 1277
Score = 150 bits (378), Expect = 1e-35
Identities = 197/861 (22%), Positives = 327/861 (37%), Gaps = 119/861 (13%)
Query: 51 DNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET 110
+NS G + R P + ++ G ++C+ G P +I+WYK +
Sbjct: 487 NNSAGVVLYQARINVRGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKWYKNSNLL-- 544
Query: 111 DKDDPRSHRMLL--PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE-AVSHNASLEVAI 167
P +HR + +G+L + + DEG Y C N L + +S + S+ V +
Sbjct: 545 ----PFNHRQVAFENNGTLKLSDV----QKEVDEGEYTC---NVLVQPQLSTSQSVHVTV 593
Query: 168 LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP--------LDDKDERIT 219
F Q ++G+ + C G TI+W+KDG P +D+ D +
Sbjct: 594 KVPPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDGRPIPGSLGVTIDNIDFTSS 653
Query: 220 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSA 279
+R L + + G Y C+ N E + ++L V P FV +P + +
Sbjct: 654 LRISNLSLMHN-----GNYTCIARNEAAAVEHQ-SQLIVRVPPKFVVQPRDQDGIYGKAV 707
Query: 280 EFKCEARGDPVPTVRWRKDDGE-LPK-------SRYEIRDDHTLKIRKVTAGDMGSYTCV 331
C A G PVPT+ W+ G +P+ R ++ + +L I+ V D G Y C
Sbjct: 708 ILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSGYYLCK 767
Query: 332 AENMVG-KAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
N VG S LTV+ P P + G+ C A G + W +E
Sbjct: 768 VSNDVGADVSKSMYLTVKIPAMITSYPNTTLATQGQKKEMSCTAHGEKPIIVRWEKEDR- 826
Query: 391 NLLFSYQPPQSSSRFSVSQTGDLTITNVQ-----RSDVGYYICQTLNVAGSIITKAYLEV 445
P + S + G+ I+ +Q R D G++ C +N G + +++
Sbjct: 827 ----IINPEMARYLVSTKEVGEEVISTLQILPTVREDSGFFSCHAINSYGE--DRGIIQL 880
Query: 446 TDVIADRPPPV------IRQGPVNQTVAVDGT-----FVLSCVATGSPVPTILWRKDGVL 494
T PP + R + T+ DG + + C + KD
Sbjct: 881 TVQEPPDPPEIEIKDVKARTITLRWTMGFDGNSPITGYDIECKNKSDSWDSAQRTKDVSP 940
Query: 495 VSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRP 554
+ I + IR G+ S PS E T + P
Sbjct: 941 QLNSATIIDIHPSSTYSIRMYAKNRIGK-----SEPSNELT-----------ITADEAAP 984
Query: 555 TDPNLIPSAPSKPEVTDVSRNTVTLSW---QPNLNSGATPTSYIIEAFSHASGSSWQ--- 608
P P + + +S ++ ++W + +L +G Y I +++G ++Q
Sbjct: 985 DGP------PQEVHLEPISSQSIRVTWKAPKKHLQNGII-RGYQIGYREYSTGGNFQFNI 1037
Query: 609 -TVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHK 667
+V + +E + L Y +V+A N G SQ +DV +
Sbjct: 1038 ISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQEIITTTLEDV----PSYPPE 1093
Query: 668 QVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWL 724
VQ S SI + W+ + + +QG++++Y AN + +
Sbjct: 1094 NVQ------------AIATSPESISISWSTLSKEALNGILQGFRVIY---WANLMDGELG 1138
Query: 725 VFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTV 784
+ T + S+ + L K NY I+ F G SE F +T E+ P PP GV
Sbjct: 1139 EIKNITTTQPSLELDGLEKYTNYSIQVLAFTRAGDGVRSEQIFTRTKEDVP-GPPAGVKA 1197
Query: 785 SKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVP 844
+ + + + VSW PP + NG++++Y V+C +FS IP L
Sbjct: 1198 AA--ASASMVFVSWLPPLK--LNGIIRKYTVFCSHPYPTVISEFEASPDSFSYRIPNLSR 1253
Query: 845 GIRYSVEVAASTGAGSGVKSE 865
+YSV V A T AG G SE
Sbjct: 1254 NRQYSVWVVAVTSAGRGNSSE 1274
Score = 127 bits (319), Expect = 9e-29
Identities = 193/853 (22%), Positives = 335/853 (39%), Gaps = 105/853 (12%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
P + P + S G +L+C G + WY+ GE + K+ +
Sbjct: 313 PLKATISPRKVKSSVGSQVSLSCSVTGTEDQELSWYRNGEILNPGKN--------VRITG 364
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVMVAV 183
+ ++ + D G Y C R + +S ++V +L D S+ +V+
Sbjct: 365 INHENLIMDHMVKSDGGAYQCFVRK---DKLSAQDYVQV-VLEDGTPKIISAFSEKVVSP 420
Query: 184 GEPAVMECQPPRGHPEPTISWKKDGSPL-----DDKDERITIRG---GKLMITYTRKSDA 235
EP + C +G P PTI+W D P+ + IT G L I+ ++ D
Sbjct: 421 AEPVSLMCN-VKGTPLPTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDG 479
Query: 236 GKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRW 295
G Y C N G + A + V P+ ++ N+ C G P +++W
Sbjct: 480 GVYRCTANNSAGVVLYQ-ARINV-RGPASIRPMKNITAIAGRDTYIHCRVIGYPYYSIKW 537
Query: 296 RKDDGELPKSRYEI--RDDHTLKIRKVTAG-DMGSYTC-VAENMVGKAEASATLTVQEPP 351
K+ LP + ++ ++ TLK+ V D G YTC V S +TV+ PP
Sbjct: 538 YKNSNLLPFNHRQVAFENNGTLKLSDVQKEVDEGEYTCNVLVQPQLSTSQSVHVTVKVPP 597
Query: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRFSVSQ- 409
F+ ++G+ V C P I W+++G +P S ++
Sbjct: 598 -FIQPFEFPRFSIGQRVFIPCVVVSGDLPITITWQKDG--------RPIPGSLGVTIDNI 648
Query: 410 --TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 467
T L I+N+ G Y C N A ++ ++ L V R PP P +Q
Sbjct: 649 DFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIV------RVPPKFVVQPRDQDGI 702
Query: 468 VDGTFVLSCVATGSPVPTILWR--KDGVLVSTQ----DSRIKQLENGVLQIRYAKLGDTG 521
+L+C A G PVPTI+W+ K + Q + RI+ L NG L I++ D+G
Sbjct: 703 YGKAVILNCSAEGYPVPTIVWKFSKGAGVPQFQPIALNGRIQVLSNGSLLIKHVVEEDSG 762
Query: 522 RYTCIASTPSG-EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEV--TDVSRNTVT 578
Y C S G + + S Y+ V+ + P T + + K E+ T +
Sbjct: 763 YYLCKVSNDVGADVSKSMYLTVKIPAMITSYPNTT----LATQGQKKEMSCTAHGEKPII 818
Query: 579 LSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAAN 638
+ W+ II S + V E V + + ++ ++ + F A N
Sbjct: 819 VRWEKE--------DRIINPEMARYLVSTKEVGEEVISTLQILPTVREDSGF-FSCHAIN 869
Query: 639 AYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVD 698
+YG +G+ VQ + + + + + +I + WT+
Sbjct: 870 SYG------------------EDRGIIQLTVQEPPDPPEIEIKD---VKARTITLRWTMG 908
Query: 699 -QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNE 757
+ I GY I + + ++ +S +V +P NS I D+ Y I+ N
Sbjct: 909 FDGNSPITGYDIECK-NKSDSWDSAQRTKDV-SPQLNSATIIDIHPSSTYSIRMYA-KNR 965
Query: 758 FQGADSEIKFAKTLEE-APSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV- 815
++ + T +E AP PPQ V + + +I V+W+ P + QNG+++ Y++
Sbjct: 966 IGKSEPSNELTITADEAAPDGPPQEVHLEPI--SSQSIRVTWKAPKKHLQNGIIRGYQIG 1023
Query: 816 ---WCLGNETRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL 871
+ G +++ I+ G + + L +Y + V A AG+G S+ + I
Sbjct: 1024 YREYSTGGNFQFNIISVDTSGDSEVYTLDNLNKFTQYGLVVQACNRAGTGPSSQ-EIITT 1082
Query: 872 DAHGNPVSPEDQV 884
P P + V
Sbjct: 1083 TLEDVPSYPPENV 1095
Score = 122 bits (307), Expect = 2e-27
Identities = 129/487 (26%), Positives = 194/487 (39%), Gaps = 62/487 (12%)
Query: 89 CKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLPSGSL--------FFLRIVHGRKSR 139
C A G P T+ WY GE + D R + P+G+L F ++H
Sbjct: 46 CPAAGIPPVTLRWYLATGEEIY----DVPGIRHVHPNGTLQIFPFPPSSFSTLIH----- 96
Query: 140 PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPE 199
+ Y C A N G+ S + ++ A+LR+ + D G AV +C P
Sbjct: 97 --DNTYYCTAENPSGKIRSQDVHIK-AVLREPYTVRVEDQKTMRGNVAVFKCIIPSSVEA 153
Query: 200 --PTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA-GKYVCVGTNM-VGE-RESEVA 254
+SW+KD L + G L I + D Y C+ + GE R+S A
Sbjct: 154 YITVVSWEKDTVSLVSGSRFLITSTGALYIKDVQNEDGLYNYRCITRHRYTGETRQSNSA 213
Query: 255 ELTVLERPSFVKRPSNLAVTVDDS-----------AEFKCEARGDPVPTVRWRKDDGELP 303
L FV P+N A ++ D E C+A G P P RW KD+ L
Sbjct: 214 RL-------FVSDPANSAPSILDGFDHRKAMAGQRVELPCKALGHPEPDYRWLKDNMPLE 266
Query: 304 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 363
S + L I + D GSY C N G A+ L V++P + PR +
Sbjct: 267 LSGRFQKTVTGLLIENIRPSDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISPRKVKSS 326
Query: 364 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 423
+G V+ C TG + W R G P + R + +L + ++ +SD
Sbjct: 327 VGSQVSLSCSVTGTEDQELSWYRNG------EILNPGKNVRITGINHENLIMDHMVKSDG 380
Query: 424 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV 483
G Y C + + Y++V V+ D P +I + V+ L C G+P+
Sbjct: 381 GAYQCFVRK--DKLSAQDYVQV--VLEDGTPKII-SAFSEKVVSPAEPVSLMCNVKGTPL 435
Query: 484 PTILWR-KDGVLVSTQDSRIKQL---ENGV---LQIRYAKLGDTGRYTCIASTPSGEATW 536
PTI W D ++ RI Q+ E V L I +++ D G Y C A+ +G +
Sbjct: 436 PTITWTLDDDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGVVLY 495
Query: 537 SAYIEVQ 543
A I V+
Sbjct: 496 QARINVR 502
Score = 107 bits (268), Expect = 7e-23
Identities = 127/490 (25%), Positives = 188/490 (38%), Gaps = 43/490 (8%)
Query: 82 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 141
G+ L CKA G P P W K +E ++ LL I + R S D
Sbjct: 239 GQRVELPCKALGHPEPDYRWLKDNMPLELSGRFQKTVTGLL---------IENIRPS--D 287
Query: 142 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPT 201
G YVC N G A L+ +P V +VG + C G +
Sbjct: 288 SGSYVCEVSNRYGTAKVIGRLYVKQPLKATI--SPRKVKSSVGSQVSLSCS-VTGTEDQE 344
Query: 202 ISWKKDGSPLD-DKDERIT-IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 259
+SW ++G L+ K+ RIT I L++ + KSD G Y C + V +
Sbjct: 345 LSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFVRKDKLSAQDYVQVVLED 404
Query: 260 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHT---- 314
P + S V+ + C +G P+PT+ W DD + K + I T
Sbjct: 405 GTPKIISAFSEKVVSPAEPVSLMCNVKGTPLPTITWTLDDDPILKGGSHRISQMITSEGN 464
Query: 315 ----LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL-GRTVT 369
L I D G Y C A N G A + V+ P ++P + A+ GR
Sbjct: 465 VVSYLNISSSQVRDGGVYRCTANNSAGVVLYQARINVRGPAS--IRPMKNITAIAGRDTY 522
Query: 370 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS-DVGYYIC 428
C G P +I W + + NLL P + + + G L +++VQ+ D G Y C
Sbjct: 523 IHCRVIGYPYYSIKWYK--NSNLL-----PFNHRQVAFENNGTLKLSDVQKEVDEGEYTC 575
Query: 429 QTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILW 488
L V + T + VT + PP I+ + F+ V +G TI W
Sbjct: 576 NVL-VQPQLSTSQSVHVTVKV----PPFIQPFEFPRFSIGQRVFIPCVVVSGDLPITITW 630
Query: 489 RKDG-VLVSTQDSRIKQLE-NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 546
+KDG + + I ++ L+I L G YTCIA + + + V+
Sbjct: 631 QKDGRPIPGSLGVTIDNIDFTSSLRISNLSLMHNGNYTCIARNEAAAVEHQSQLIVRVPP 690
Query: 547 VPVQPPRPTD 556
V PR D
Sbjct: 691 KFVVQPRDQD 700
Score = 82.4 bits (202), Expect = 3e-15
Identities = 79/319 (24%), Positives = 134/319 (42%), Gaps = 41/319 (12%)
Query: 473 VLSCVATGSPVPTILWRKDG---VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 529
VL C A G P P + W KD + T D R NG IR K D+G Y+CIA+
Sbjct: 1304 VLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANN 1363
Query: 530 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGA 589
G ++VQ VP PR T V+ + +++TLSW P N G+
Sbjct: 1364 NWGSDEIILNLQVQ---VPPDQPRLT-------------VSKTTSSSITLSWLPGDNGGS 1407
Query: 590 TPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 649
+ YI++ +S + W + + + ++ LK Y F + A N G P +IS
Sbjct: 1408 SIRGYILQ-YSEDNSEQWGSFPISPSERSYRLENLKCGTWYKFTLTAQNGVG---PGRIS 1463
Query: 650 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKI 709
+ ++ + + Q +++ + + L+ + W + I + +
Sbjct: 1464 EIIEAKTLGKEPQFSKEQELFASINTTRVRLN----------LIGW--NDGGCPITSFTL 1511
Query: 710 LYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAK 769
YRP G + W + RT S ++ DL++ YE++ R N A+ + FA
Sbjct: 1512 EYRP----FGTTVWTTAQ-RTSLSKSYILYDLQEATWYELQMR-VCNSAGCAEKQANFAT 1565
Query: 770 TLEEAPSAPPQGVTVSKND 788
+ + PP +V +N+
Sbjct: 1566 LNYDGSTIPPLIKSVVQNE 1584
Score = 53.5 bits (127), Expect = 2e-06
Identities = 30/74 (40%), Positives = 36/74 (48%), Gaps = 5/74 (6%)
Query: 283 CEARGDPVPTVRWRKDDGELPK-----SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 337
C+A GDP P V+W KD P R I + + IR V A D G Y+C+A N G
Sbjct: 1307 CKAVGDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWG 1366
Query: 338 KAEASATLTVQEPP 351
E L VQ PP
Sbjct: 1367 SDEIILNLQVQVPP 1380
Score = 47.4 bits (111), Expect = 1e-04
Identities = 81/387 (20%), Positives = 144/387 (37%), Gaps = 68/387 (17%)
Query: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVT- 369
D + +I ++ S VA G+ +S +TV+ + K +++ TVT
Sbjct: 1242 DSFSYRIPNLSRNRQYSVWVVAVTSAGRGNSSEIITVEP----LAKAPARILTFSGTVTT 1297
Query: 370 -------FQCEATGNPQPAIFWRRE--GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420
C+A G+P PA+ W ++ G+ +L+ R S+ G I V+
Sbjct: 1298 PWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLV------TIDGRRSIFSNGSFIIRTVKA 1351
Query: 421 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD-------GTFV 473
D GYY C N GS L+V V D+P + + + ++ + G+ +
Sbjct: 1352 EDSGYYSCIANNNWGSDEIILNLQV-QVPPDQPRLTVSK-TTSSSITLSWLPGDNGGSSI 1409
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533
+ S + W + S + R++ L K G ++T A G
Sbjct: 1410 RGYILQYSEDNSEQWGSFPISPSERSYRLENL----------KCGTWYKFTLTAQNGVGP 1459
Query: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP-T 592
S IE + G +P + L S T V N + W N G P T
Sbjct: 1460 GRISEIIEAKTLG--KEPQFSKEQELFASI----NTTRVRLNLI--GW----NDGGCPIT 1507
Query: 593 SYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD-------- 644
S+ +E + + W T +++ + L+ Y +R N+ G ++
Sbjct: 1508 SFTLE-YRPFGTTVWTTAQRTSLSKSYILYDLQEATWYELQMRVCNSAGCAEKQANFATL 1566
Query: 645 -------PSQISDPVKTQDVLPTSQGV 664
P I V+ ++ L T++G+
Sbjct: 1567 NYDGSTIPPLIKSVVQNEEGLTTNEGL 1593
Score = 35.0 bits (79), Expect = 0.60
Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 10/90 (11%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK--GGERVETDKDDPRSHRMLLPS 124
P RI+ + + L CKA G P+P ++W K G D RS + +
Sbjct: 1285 PARILTFSGTVTTPWMKDIVLPCKAVGDPSPAVKWMKDSNGTPSLVTIDGRRS---IFSN 1341
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLG 154
GS F +R V D G Y C+A N G
Sbjct: 1342 GS-FIIRTVKAE----DSGYYSCIANNNWG 1366
Score = 33.5 bits (75), Expect = 1.8
Identities = 38/171 (22%), Positives = 67/171 (39%), Gaps = 17/171 (9%)
Query: 196 GHPEPTISWKKD--GSP--LDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
G P P + W KD G+P + R G +I + D+G Y C+ N G E
Sbjct: 1311 GDPSPAVKWMKDSNGTPSLVTIDGRRSIFSNGSFIIRTVKAEDSGYYSCIANNNWGSDEI 1370
Query: 252 EVAELTVLERPS----FVKRPSNLAVTVD--DSAEFKCEARGDPVPTVRWRKDDGELPKS 305
+ L V P V + ++ ++T+ RG +++ +D+ E S
Sbjct: 1371 -ILNLQVQVPPDQPRLTVSKTTSSSITLSWLPGDNGGSSIRG---YILQYSEDNSEQWGS 1426
Query: 306 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL---TVQEPPHF 353
+ + ++ + G +T A+N VG S + T+ + P F
Sbjct: 1427 FPISPSERSYRLENLKCGTWYKFTLTAQNGVGPGRISEIIEAKTLGKEPQF 1477
>gi|157311649 neogenin homolog 1 [Homo sapiens]
Length = 1461
Score = 223 bits (568), Expect = 1e-57
Identities = 224/825 (27%), Positives = 342/825 (41%), Gaps = 100/825 (12%)
Query: 74 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 133
P D + +G LNC A P+P IEW K G + DD R LLP GSLF +V
Sbjct: 59 PVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDD---RRQLLPDGSLFISNVV 115
Query: 134 HGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 192
H + ++PDEG Y CVA LG +S A L VA L F P V G A++ C+
Sbjct: 116 HSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGL-PRFTSQPEPSSVYAGNNAILNCE 174
Query: 193 PPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 252
P + W+++ PL D I + G L+I+ + D G Y CV + + S+
Sbjct: 175 V-NADLVPFVRWEQNRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSD 233
Query: 253 VAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP--- 303
EL VL P F+K+PS L + C A G P PT++W K++ L
Sbjct: 234 EVELKVLPDPEVISDLVFLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTES 293
Query: 304 KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA 363
R + +L+I VT D G+Y C+A+N EA A LTVQ P F+ +P +
Sbjct: 294 SERLVLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAH 353
Query: 364 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 423
+ F+CE TG P P + W + G + Y F + + +L + + +SD
Sbjct: 354 ESMDIVFECEVTGKPTPTVKWVKNGDMVIPSDY--------FKIVKEHNLQVLGLVKSDE 405
Query: 424 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSP 482
G+Y C N G+ A L + + P + P + ++ T F+ T +
Sbjct: 406 GFYQCIAENDVGNAQAGAQLIILEHAPATTGP-LPSAPRDVVASLVSTRFIKLTWRTPAS 464
Query: 483 VP-------TILWRKDGVLVSTQDSRIKQLEN-GVLQIRYAKLGDTGRY--TCIASTPSG 532
P ++ + K+G+ R++ + G +Q+ L Y +A G
Sbjct: 465 DPHGDNLTYSVFYTKEGI----ARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHG 520
Query: 533 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 592
SA + V E VQ P P PNL A S ++T++W+ ++
Sbjct: 521 SGESSAPLRV-ETQPEVQLPGPA-PNLRAYA--------ASPTSITVTWETPVSGNGEIQ 570
Query: 593 SYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAY--GISDPSQISD 650
+Y + + +V + + I GLK Y F V A N + G+S P
Sbjct: 571 NYKLYYMEKGTDKEQDV---DVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDV--- 624
Query: 651 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYIQGY 707
V+T +P++ N L + N S SI +HW Q+ I GY
Sbjct: 625 AVRTLSDVPSAAP----------QNLSLEVRN-----SKSIMIHWQPPAPATQNGQITGY 669
Query: 708 KILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKF 767
KI YR + ++ LV + + S +I L +G Y + G ++
Sbjct: 670 KIRYRKASRKSDVTETLV----SGTQLSQLIEGLDRGTEYNFRVAALTINGTGPATDWLS 725
Query: 768 AKTLE---------EAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-WC 817
A+T E E PS+ V T+I+VSW PP + QN +V+ Y + +
Sbjct: 726 AETFESDLDETRVPEVPSSLHVRPLV-------TSIVVSWTPP--ENQNIVVRGYAIGYG 776
Query: 818 LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 862
+G+ I VD I L P Y + + A G G+
Sbjct: 777 IGSPHAQTIK--VDYKQRYYTIENLDPSSHYVITLKAFNNVGEGI 819
Score = 147 bits (371), Expect = 8e-35
Identities = 220/889 (24%), Positives = 344/889 (38%), Gaps = 141/889 (15%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
PR P V G A LNC+ P + W + + + D + LPSG L
Sbjct: 152 PRFTSQPEPSSVYAGNNAILNCEVNADLVPFVRWEQNRQPLLLD-----DRVIKLPSGML 206
Query: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDVM 180
G D G+Y CV + G ++ +E+ +L D F + PS ++
Sbjct: 207 VISNATEG-----DGGLYRCVVES--GGPPKYSDEVELKVLPDPEVISDLVFLKQPSPLV 259
Query: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDER-ITIRGGKLMITYTRKSDAGKY 238
+G+ V+ C G P PTI W K+ LD + ER + + GG L I+ + DAG Y
Sbjct: 260 RVIGQDVVLPC-VASGLPTPTIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTY 318
Query: 239 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 298
C+ N E++ AELTV +P F+K+P+N+ F+CE G P PTV+W K+
Sbjct: 319 FCIADNGNETIEAQ-AELTVQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN 377
Query: 299 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV-- 355
D +P ++I +H L++ + D G Y C+AEN VG A+A A L + E
Sbjct: 378 GDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLIILEHAPATTGP 437
Query: 356 ---KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS----QNLLFS-YQPPQSSSRFSV 407
PRD V +L T + + WR S NL +S + + +R V
Sbjct: 438 LPSAPRDVVASLVSTRFIK----------LTWRTPASDPHGDNLTYSVFYTKEGIARERV 487
Query: 408 SQTG-----DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 462
T +TI N+ + V + N GS + A L V + P V GP
Sbjct: 488 ENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRV-----ETQPEVQLPGPA 542
Query: 463 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG-DTG 521
L A T+ W T S +++N ++ Y + G D
Sbjct: 543 PN---------LRAYAASPTSITVTW-------ETPVSGNGEIQN--YKLYYMEKGTDKE 584
Query: 522 RYTCIAS---TPSGEATWSAY----IEVQEFGVPVQPPRPTDPNL--IPS-APSKPEVTD 571
+ ++S T +G ++ Y + + G V P L +PS AP +
Sbjct: 585 QDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEV 644
Query: 572 VSRNTVTLSWQP--NLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET---SAIKGLKP 626
+ ++ + WQP T Y I + S V E + + T I+GL
Sbjct: 645 RNSKSIMIHWQPPAPATQNGQITGYKIR---YRKASRKSDVTETLVSGTQLSQLIEGLDR 701
Query: 627 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 686
Y F V A I+ +D + + +D +V + LH+ P V
Sbjct: 702 GTEYNFRVAALT---INGTGPATDWLSAETF---ESDLDETRVPEVPSS--LHV-RPLV- 751
Query: 687 SSSSIEVHWT-VDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 745
+SI V WT + Q+ ++GY I Y G+ H ++ + ++ R I +L
Sbjct: 752 --TSIVVSWTPPENQNIVVRGYAIGY-GIGSPHAQTIKVDYKQR-----YYTIENLDPSS 803
Query: 746 NYEIKARPFFNEFQGA-------------DSEI-------KFAKTLEEAPSAPPQGVTVS 785
+Y I + F N +G SE+ + + P PP GV S
Sbjct: 804 HYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQAS 863
Query: 786 KNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPG 845
+ I + P+ + + Y V N K + +T S ++ L P
Sbjct: 864 ILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNANATTLSYLVTGLKPN 923
Query: 846 IRYSVEVAASTGAGSGVKSEPQFIQLDAHGN-----PVSPEDQVSLAQQ 889
Y V + G S S + AHG P SP V++ +
Sbjct: 924 TLYEFSVMVTKGRRSSTWS------MTAHGTTFELVPTSPPKDVTVVSK 966
Score = 122 bits (305), Expect = 4e-27
Identities = 189/864 (21%), Positives = 329/864 (38%), Gaps = 98/864 (11%)
Query: 71 VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFL 130
++ PS L+ G+ L C A G PTPTI+W K E ++T+ + +LL GSL
Sbjct: 252 LKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALDTESSE---RLVLLAGGSLEIS 308
Query: 131 RIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVME 190
+ + D G Y C+A N E + A L V + +F + P+++ V E
Sbjct: 309 DV-----TEDDAGTYFCIADNG-NETIEAQAELTVQA-QPEFLKQPTNIYAHESMDIVFE 361
Query: 191 CQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERE 250
C+ G P PT+ W K+G + D ++ L + KSD G Y C+ N VG +
Sbjct: 362 CEVT-GKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 420
Query: 251 SEVAELTVLERPSFV-----KRPSNLAVTVDDSAEFKCEAR-------GDPVPTVRWRKD 298
+ A+L +LE P ++ ++ + K R GD + +
Sbjct: 421 AG-AQLIILEHAPATTGPLPSAPRDVVASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTK 479
Query: 299 DGELPKSRYEIRD---DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV 355
+G + + R E + + I+ + + + +A+N G E+SA L V+ P +
Sbjct: 480 EG-IARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEVQL 538
Query: 356 K-PRDQVVALGR-----TVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 409
P + A TVT++ +GN + QN Y + V
Sbjct: 539 PGPAPNLRAYAASPTSITVTWETPVSGNGE---------IQNYKLYYMEKGTDKEQDVDV 589
Query: 410 TG-DLTITNVQRSDVGYYICQTLNVAGSIITK---AYLEVTDVIADRPPPVIRQGPVNQT 465
+ TI +++ + N G ++ A ++DV + P + + +++
Sbjct: 590 SSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSKS 649
Query: 466 VAVDGTFVLSCVATGSPVP-TILWRK-----DGVLVSTQDSRIKQLENGVLQIRYAKLGD 519
+ + G I +RK D +++ QL G+ + G
Sbjct: 650 IMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDR------GT 703
Query: 520 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 579
+ A T +G + ++ + F + R +P PS V + ++ +
Sbjct: 704 EYNFRVAALTINGTGPATDWLSAETFESDLDETR------VPEVPSSLHVRPLV-TSIVV 756
Query: 580 SWQPNLNSGATPTSYIIEAFSHASGSSW-QTVAENVKTETSAIKGLKPNAIYLFLVRAAN 638
SW P N Y A + GS QT+ + K I+ L P++ Y+ ++A N
Sbjct: 757 SWTPPENQNIVVRGY---AIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFN 813
Query: 639 AYGISDP---SQISDP-VKTQDV------LPTSQGVDHKQVQRELGNAVLHLHNPTVL-- 686
G P S ++ P T +V P + D + +G L + T+
Sbjct: 814 NVGEGIPLYESAVTRPHTDTSEVDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRIT 873
Query: 687 -SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGV 745
+ +S+ H + Y +K P+ + ++ S ++ L+
Sbjct: 874 WADNSLPKHQKITDSRYYTVRWKTNI-PANTKYKNANATTL--------SYLVTGLKPNT 924
Query: 746 NYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDT 805
YE S T E P++PP+ VTV +G I+V+WQPP E
Sbjct: 925 LYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTIIVNWQPPSE-- 982
Query: 806 QNGMVQEYKVWC---LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 862
NG + Y ++ + E + + V G+ + I L Y ++ A G G
Sbjct: 983 ANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSKGMGP 1042
Query: 863 KSEP-QFIQLDAHGNPVSPEDQVS 885
SE QF A + P DQ S
Sbjct: 1043 MSEAVQFRTPKADSSDKMPNDQAS 1066
Score = 97.4 bits (241), Expect = 1e-19
Identities = 147/630 (23%), Positives = 217/630 (34%), Gaps = 92/630 (14%)
Query: 264 FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIRKV 320
F+ P + S C A +P P + W+KD L R ++ D +L I V
Sbjct: 55 FLVEPVDTLSVRGSSVILNCSAYSEPSPKIEWKKDGTFLNLVSDDRRQLLPDGSLFISNV 114
Query: 321 TAG-----DMGSYTCVA--ENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCE 373
D G Y CVA E++ +A L V P F +P V G CE
Sbjct: 115 VHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNCE 174
Query: 374 ATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNV 433
+ P + W + + QP R +G L I+N D G Y C +
Sbjct: 175 VNADLVPFVRWEQ--------NRQPLLLDDRVIKLPSGMLVISNATEGDGGLYRCVVESG 226
Query: 434 A----GSIITKAYLEVTDVIAD-----RPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484
+ L +VI+D +P P++R + VL CVA+G P P
Sbjct: 227 GPPKYSDEVELKVLPDPEVISDLVFLKQPSPLVR--------VIGQDVVLPCVASGLPTP 278
Query: 485 TILWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
TI W K+ + T+ S R+ L G L+I D G Y CIA +G T A E+
Sbjct: 279 TIKWMKNEEALDTESSERLVLLAGGSLEISDVTEDDAGTYFCIAD--NGNETIEAQAELT 336
Query: 544 EFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSH-- 601
P +PT+ S E + T T+ W N P+ Y H
Sbjct: 337 VQAQPEFLKQPTNIYAHESMDIVFECEVTGKPTPTVKWVKN-GDMVIPSDYFKIVKEHNL 395
Query: 602 -------ASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 654
+ +Q +AEN A L ++ A A PS D V
Sbjct: 396 QVLGLVKSDEGFYQCIAENDVGNAQA-------GAQLIILEHAPATTGPLPSAPRDVV-- 446
Query: 655 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPS 714
+++S+ I++ W + G + Y
Sbjct: 447 ----------------------------ASLVSTRFIKLTWRTPASDPH--GDNLTYSVF 476
Query: 715 GANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEA 774
G + V P + V I +L Y + G S +T E
Sbjct: 477 YTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNKHGSGESSAPLRVETQPEV 536
Query: 775 PSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGST 834
P + + T+I V+W+ P + NG +Q YK++ + T + VD S+
Sbjct: 537 -QLPGPAPNLRAYAASPTSITVTWETPV--SGNGEIQNYKLYYMEKGT--DKEQDVDVSS 591
Query: 835 FSVVIPFLVPGIRYSVEVAASTGAGSGVKS 864
S I L YS V A G GV +
Sbjct: 592 HSYTINGLKKYTEYSFRVVAYNKHGPGVST 621
Score = 51.2 bits (121), Expect = 8e-06
Identities = 31/119 (26%), Positives = 55/119 (46%), Gaps = 12/119 (10%)
Query: 38 NDHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTP 97
+D GT +DN + ++ Q P ++ P+++ + C+ G+PTP
Sbjct: 313 DDAGTYFCIADNGNETIEAQAELTVQAQ--PEFLKQPTNIYAHESMDIVFECEVTGKPTP 370
Query: 98 TIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEA 156
T++W K G+ V P + ++ +L L +V + DEG Y C+A N +G A
Sbjct: 371 TVKWVKNGDMV-----IPSDYFKIVKEHNLQVLGLV-----KSDEGFYQCIAENDVGNA 419
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 221 bits (563), Expect = 5e-57
Identities = 170/559 (30%), Positives = 244/559 (43%), Gaps = 33/559 (5%)
Query: 63 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 122
Q PP I P+++ V TL C+A G P P+I W K G + D++ S+R LL
Sbjct: 3799 QVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ-NSYR-LL 3856
Query: 123 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 182
SGSL + S D Y C N G+ L V + P+D +V
Sbjct: 3857 SSGSLVIIS-----PSVDDTATYECTVTNGAGDD-KRTVDLTVQV-PPSIADEPTDFLVT 3909
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCV 241
PAV+ C G P P+I W K+G L + + I G + I T+ + AG+Y CV
Sbjct: 3910 KHAPAVITCTAS-GVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCV 3968
Query: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 301
N G V L V E P +PS L V +++ CEA G P P + W+K+
Sbjct: 3969 ARNAAGSAHRHVT-LHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGIN 4027
Query: 302 LPKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRD 359
+ S + + L+I + D G+Y CVA+N G A L VQ PP ++
Sbjct: 4028 VNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKE 4087
Query: 360 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 419
V+A+ + +T CEA G P P I W ++G + S R V +G L I VQ
Sbjct: 4088 YVIAVDKPITLSCEADGLPPPDITWHKDGRAIV--------ESIRQRVLSSGSLQIAFVQ 4139
Query: 420 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 479
D G+Y C NVAGS T L V PP IR + TV + +L CVA
Sbjct: 4140 PGDAGHYTCMAANVAGSSSTSTKLTV------HVPPRIRSTEGHYTVNENSQAILPCVAD 4193
Query: 480 GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 539
G P P I W+KD VL++ + G L + L D+G YTC+A+ +GE T +
Sbjct: 4194 GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVS 4253
Query: 540 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNL-----NSGATPTSY 594
+ V + P N + T + +T ++ N+ +S +
Sbjct: 4254 LTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSEL 4313
Query: 595 IIEAFSHASGSSWQTVAEN 613
+IE S ++ AEN
Sbjct: 4314 VIERVSKEDSGTYVCTAEN 4332
Score = 213 bits (541), Expect = 2e-54
Identities = 146/484 (30%), Positives = 220/484 (45%), Gaps = 33/484 (6%)
Query: 67 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I + P D+ V + TL CK++ P P I W + GER++ + R+ + S
Sbjct: 3619 PPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQA------TPRVRILS 3672
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
G + L+I D Y CVA N G+ + + + + P +++ +
Sbjct: 3673 GGRY-LQI--NNADLGDTANYTCVASNIAGKTTRE--FILTVNVPPNIKGGPQSLVILLN 3727
Query: 185 EPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCVGT 243
+ V+EC G P P I+W+KDG+ L R +I G L I +D G+Y+C+ T
Sbjct: 3728 KSTVLECIA-EGVPTPRITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMAT 3786
Query: 244 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 303
N G + +L V PS P+N+ V V+ CEA G P P++ WRK+ L
Sbjct: 3787 NAAGTDRRRI-DLQVHVPPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLN 3845
Query: 304 ----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRD 359
++ Y + +L I + D +Y C N G + + LTVQ PP +P D
Sbjct: 3846 VDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTD 3905
Query: 360 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 419
+V C A+G P P+I W + G + L P+ + + +G + I Q
Sbjct: 3906 FLVTKHAPAVITCTASGVPFPSIHWTKNGIRLL------PRGDG-YRILSSGAIEILATQ 3958
Query: 420 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 479
+ G Y C N AGS L V + PPVI+ P V ++ +L C AT
Sbjct: 3959 LNHAGRYTCVARNAAGSAHRHVTLHVHE------PPVIQPQPSELHVILNNPILLPCEAT 4012
Query: 480 GSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 539
G+P P I W+K+G+ V+T L +G LQI A D G Y C+A P+G A
Sbjct: 4013 GTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPAGTALGKIK 4072
Query: 540 IEVQ 543
+ VQ
Sbjct: 4073 LNVQ 4076
Score = 212 bits (539), Expect = 3e-54
Identities = 158/519 (30%), Positives = 231/519 (44%), Gaps = 38/519 (7%)
Query: 87 LNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYV 146
+ C+A G P P I W K G + SH LL +G + +RIV + S D VY
Sbjct: 3362 IECRATGTPPPQINWLKNGLPLPLS-----SHIRLLAAGQV--IRIVRAQVS--DVAVYT 3412
Query: 147 CVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKK 206
CVA N G H A D ++ V G M C G P P+++W +
Sbjct: 3413 CVASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITD-GTPAPSMAWLR 3471
Query: 207 DGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF- 264
DG PL D ++ G L + D+GKY C+ +N GE L VLE P
Sbjct: 3472 DGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFI-LKVLEPPHIN 3530
Query: 265 -VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRY--EIRDDHTLKIRKVT 321
+ ++V V++ E C A G P P + W KD LP++ + L+I
Sbjct: 3531 GSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQ 3590
Query: 322 AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV--KPRDQVVALGRTVTFQCEATGNPQ 379
D G YTC+A + G + + V PP+ +PRD V R VT +C++ P
Sbjct: 3591 VEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPP 3650
Query: 380 PAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSII 438
P I W R G + Q++ R + G L I N D Y C N+AG
Sbjct: 3651 PVITWLRNGERL--------QATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKT- 3701
Query: 439 TKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQ 498
T+ ++ +V PP I+ GP + + ++ + VL C+A G P P I WRKDG +++
Sbjct: 3702 TREFILTVNV-----PPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGN 3756
Query: 499 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN 558
+R LENG L I+ A + DTGRY C+A+ +G T I++Q P P PT+
Sbjct: 3757 HARYSILENGFLHIQSAHVTDTGRYLCMATNAAG--TDRRRIDLQVHVPPSIAPGPTNMT 3814
Query: 559 LIPSAPSKPEVTDVSRNTVTLSWQPN---LNSGATPTSY 594
+I + + +++W+ N LN SY
Sbjct: 3815 VIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQNSY 3853
Score = 206 bits (525), Expect = 1e-52
Identities = 145/482 (30%), Positives = 212/482 (43%), Gaps = 31/482 (6%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I H + +++ +P TL+C+A+G P P I W+K G + + +L SGS
Sbjct: 4078 PPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVES-----IRQRVLSSGS 4132
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
L + G D G Y C+A N G + S + L V + R V
Sbjct: 4133 LQIAFVQPG-----DAGHYTCMAANVAGSS-STSTKLTVHV-PPRIRSTEGHYTVNENSQ 4185
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTNM 245
A++ C G P P I+WKKD L + + T G+L++ D+G Y CV N
Sbjct: 4186 AILPCVAD-GIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNA 4244
Query: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
GE ++ LTV P+F + P ++++ + C+A G P+P + W ++ +P
Sbjct: 4245 AGE-DTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAH 4303
Query: 306 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK-PRDQVVAL 364
+ L I +V+ D G+Y C AEN VG +A + V+EPP F P + + L
Sbjct: 4304 FDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPL 4363
Query: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 424
G CE G+P P I W R+G + S R G L I D G
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDI--------EISHRIRQLGNGSLAIYGTVNEDAG 4415
Query: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484
Y C N AG + L + + PP+I PV + G +L+C ATG P P
Sbjct: 4416 DYTCVATNEAGVVERSMSLTL------QSPPIITLEPVETVINAGGKIILNCQATGEPQP 4469
Query: 485 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 544
TI W + G +S D R+ L N L I A+ DT + C+A G + VQ
Sbjct: 4470 TITWSRQGHSIS-WDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528
Query: 545 FG 546
G
Sbjct: 4529 HG 4530
Score = 196 bits (498), Expect = 2e-49
Identities = 151/485 (31%), Positives = 230/485 (47%), Gaps = 47/485 (9%)
Query: 76 DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHG 135
D+I++ P +L C+ P PT+ WYK G + T D ++LP G + +
Sbjct: 2788 DVIINN--PISLYCETNAAPPPTLTWYKDGHPL-TSSDKV----LILPGGRVLQIP---- 2836
Query: 136 RKSRPDEGVYVCVARNYLGE-AVSHNASLEVA-ILRDDFRQNPSDVMVAVGEPAVMECQP 193
R D G Y CVA N GE ++ ++ + V I++ P +V V V + A++EC
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALIECLS 2896
Query: 194 PRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERESE 252
G P P SW+KDG PL + D + G+++ I T+ +D G+YVCV N G + +
Sbjct: 2897 S-GSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAK-K 2954
Query: 253 VAELTVLERPSFV-KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG--ELPKSRYEI 309
L V PS + + NL V V++ CE G P P + W K++ +L + +
Sbjct: 2955 YFNLNVHVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIV 3014
Query: 310 RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV------VA 363
TL+I + D G YTC+A N G+++ +LTV PP +K D V
Sbjct: 3015 PGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVYVPPS--IKDHDSESLSVVNVR 3072
Query: 364 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSD 422
G +V+ +CE+ P P I W + G S+ + G L I + SD
Sbjct: 3073 EGTSVSLECESNAVPPPVITWYKNGRMIT--------ESTHVEILADGQMLHIKKAEVSD 3124
Query: 423 VGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVATG 480
G Y+C+ +NVAG +L V PP I +GP + + + L+C ATG
Sbjct: 3125 TGQYVCRAINVAGRDDKNFHLNVY------VPPSI-EGPEREVIVETISNPVTLTCDATG 3177
Query: 481 SPVPTILWRKDGVLVSTQDS-RIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGEATWSA 538
P PTI W K+ + DS ++ L G LQI ++ D+G YTCIAS G+A
Sbjct: 3178 IPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYY 3237
Query: 539 YIEVQ 543
++ +Q
Sbjct: 3238 FLSIQ 3242
Score = 192 bits (487), Expect = 3e-48
Identities = 149/517 (28%), Positives = 235/517 (45%), Gaps = 49/517 (9%)
Query: 52 NSLGYTGSRLRQEDFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 108
N G T + + P ++ E +++ V + L C+ EG P+P I WYK +V
Sbjct: 1342 NEAGTTERKYNLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQV 1401
Query: 109 ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 168
S + +G + L R + D G Y C A N G + + +++V +
Sbjct: 1402 TES-----STIQTVNNGKILKLF----RATPEDAGRYSCKAINIAGTSQKY-FNIDVLVP 1451
Query: 169 RDDFRQN-PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL--DDKDERITIRGGKL 225
N P++V V + +ECQ +G P P I W KDG PL D + + RG L
Sbjct: 1452 PTIIGTNFPNEVSVVLNRDVALECQV-KGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVL 1510
Query: 226 MITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKC 283
+ R++D G+Y C +N G++ ++ +LT+ PS ++++V ++ + +C
Sbjct: 1511 HLKNARRNDKGRYQCTVSNAAGKQAKDI-KLTIYIPPSIKGGNVTTDISVLINSLIKLEC 1569
Query: 284 EARGDPVPTVRWRKDDGELPKSRYEIRDD--HTLKIRKVTAGDMGSYTCVAENMVGKAEA 341
E RG P+P + W KD + S + D L I + D +YTC N+ G AE
Sbjct: 1570 ETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEK 1629
Query: 342 SATLTVQEPPHF---VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 398
S + V PP + P ++ V + ++T +C+A GNP P + W ++G P
Sbjct: 1630 SFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGV--------P 1681
Query: 399 PQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI 457
+++ + G L I + Q D G YIC +VAG K ++V PP I
Sbjct: 1682 VKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVL------VPPAI 1735
Query: 458 RQGPVNQ--TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYA 515
G V V+ L C TGSP PTI+W KDG L+ +D L L I A
Sbjct: 1736 EGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQA 1795
Query: 516 KLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 552
++ +TG Y C+A+ +G+ +EF V V P
Sbjct: 1796 QVSNTGLYRCMAANTAGD-------HKKEFEVTVHVP 1825
Score = 191 bits (484), Expect = 7e-48
Identities = 148/500 (29%), Positives = 223/500 (44%), Gaps = 52/500 (10%)
Query: 73 HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 132
HP+++IV++G+ +L C+ +G P PT+ W K G + K +L G + L+
Sbjct: 2298 HPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVE-----ILDEGHILQLKN 2352
Query: 133 VHGRKSRPDEGVYVCVARNYLGEA-VSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMEC 191
+H D G YVCVA N G ++ S+ ++P ++ V + C
Sbjct: 2353 IHVS----DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTC 2408
Query: 192 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERE 250
+ G P P+I+W KDG P+ + + GG+++ + T DAG+Y CV N GE E
Sbjct: 2409 EAS-GIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE-E 2466
Query: 251 SEVAELTVLERPSFVKRPS--NLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK--SR 306
++ L+VL P V + ++ V S CE G+PVP + W KD L + +
Sbjct: 2467 RKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAH 2526
Query: 307 YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV-----KPRDQV 361
+ I L+I V G YTC+A + G S +L V P P D
Sbjct: 2527 HIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVT 2586
Query: 362 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQR 420
V L + CEA P I W ++G+ P +S+ + G L I N Q
Sbjct: 2587 VILNSPTSLVCEAYSYPPATITWFKDGT--------PLESNRNIRILPGGRTLQILNAQE 2638
Query: 421 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG--------PVNQTVAVDGTF 472
+ G Y C N AG +I + EV I PP+I +G P + V+ T
Sbjct: 2639 DNAGRYSCVATNEAGEMIK--HYEVKVYI----PPIINKGDLWGPGLSPKEVKIKVNNTL 2692
Query: 473 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 532
L C A P ++ W KDG + + D LQI+ A++ DTGRYTC+AS +G
Sbjct: 2693 TLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAG 2752
Query: 533 EATWSAYIEVQEFGVPVQPP 552
E + +F V +Q P
Sbjct: 2753 E-------DELDFDVNIQVP 2765
Score = 189 bits (480), Expect = 2e-47
Identities = 170/605 (28%), Positives = 269/605 (44%), Gaps = 91/605 (15%)
Query: 67 PPRIVEHPS--DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP IV + D+ V + + TL C+ G P P I W+K G+ ++ D+ +H ++ S
Sbjct: 2477 PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE----AHHII--S 2530
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGE---AVSHNASLEVAILRDDFRQNPSDVMV 181
G F L+I + + P G Y C+A + G + S N + I NP DV V
Sbjct: 2531 GGRF-LQITNVQV--PHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTV 2587
Query: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVC 240
+ P + C+ +P TI+W KDG+PL+ +++ RI G L I ++ +AG+Y C
Sbjct: 2588 ILNSPTSLVCEA-YSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSC 2646
Query: 241 VGTNMVGERESEVAELTVLERPSFVK--------RPSNLAVTVDDSAEFKCEARGDPVPT 292
V TN GE E+ V P K P + + V+++ +CEA P +
Sbjct: 2647 VATNEAGEMIKHY-EVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSAS 2705
Query: 293 VRWRKDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 349
+ W KD G+ KS + + HTL+I++ D G YTCVA N+ G+ E + +Q
Sbjct: 2706 LSWYKD-GQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQV 2764
Query: 350 PPHFVV------------KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQ 397
PP F + V + ++ CE P P + W ++G
Sbjct: 2765 PPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDG--------H 2816
Query: 398 PPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 456
P SS + + G L I + D G Y C +N AG + + V PP+
Sbjct: 2817 PLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVL------VPPI 2870
Query: 457 IRQG----PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQ 511
I+ P TV V+ + ++ C+++GSP P W+KDG + +D K L NG +LQ
Sbjct: 2871 IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPL-LEDDHHKFLSNGRILQ 2929
Query: 512 IRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD 571
I ++ D GRY C+A +G A + F + V P P++I P +T
Sbjct: 2930 ILNTQITDIGRYVCVAENTAGSAK-------KYFNLNVHVP----PSVI--GPKSENLTV 2976
Query: 572 VSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYL 631
V N ++L+ + SG P SW + +K T+ + + P L
Sbjct: 2977 VVNNFISLTCEV---SGFPPPDL-----------SWLKNEQPIKLNTNTL--IVPGGRTL 3020
Query: 632 FLVRA 636
++RA
Sbjct: 3021 QIIRA 3025
Score = 181 bits (459), Expect = 5e-45
Identities = 155/536 (28%), Positives = 236/536 (44%), Gaps = 50/536 (9%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I+ ++ V + L C+++ P PT+ W K G + L S +
Sbjct: 2103 PPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPG-------LSISEN 2155
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAIL---RDDFRQNPSDVMVA 182
L+I + D G Y C A N G+ ++N ++ V D+ Q + V
Sbjct: 2156 RSVLKIEDAQVQ--DTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQ----LTVI 2209
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGG--KLMITYTRKSDAGKYV 239
G + C+ G P P + WKK GSP L D R+ I G +L I+ KSDA Y
Sbjct: 2210 EGNLISLLCESS-GIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYS 2268
Query: 240 CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
CV +N+ G + E L V RP+ P+ + VT S +CE +G P PTV W
Sbjct: 2269 CVASNVAGTAKKEY-NLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPTVTWM 2327
Query: 297 KDDGELPKSR-YEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354
KD L K++ EI D+ H L+++ + D G Y CVA N+ G + L+V PP +
Sbjct: 2328 KDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSII 2387
Query: 355 ---VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
P + V +V+ CEA+G P P+I W ++G + S+S +S
Sbjct: 2388 GNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDG-------WPVSLSNSVRILSGGR 2440
Query: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT-VAVDG 470
L + D G Y C N AG ++ + PP ++ + + V
Sbjct: 2441 MLRLMQTTMEDAGQYTCVVRNAAGE-----ERKIFGLSVLVPPHIVGENTLEDVKVKEKQ 2495
Query: 471 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 530
+ L+C TG+PVP I W KDG + ++ LQI ++ TGRYTC+AS+P
Sbjct: 2496 SVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSP 2555
Query: 531 SGEATWSAYIEVQEFGVPV-----QPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 581
+G + S + V F P P D +I ++P+ S T++W
Sbjct: 2556 AGHKSRSFSLNV--FVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITW 2609
Score = 179 bits (455), Expect = 2e-44
Identities = 157/548 (28%), Positives = 236/548 (43%), Gaps = 47/548 (8%)
Query: 67 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I+ P+++ V L C+ +G P P I W+K G+ + DP LL
Sbjct: 1451 PPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLG--DPNVE--LLDR 1506
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN-PSDVMVAV 183
G + L+ R D+G Y C N G+ + L + I N +D+ V +
Sbjct: 1507 GQVLHLK----NARRNDKGRYQCTVSNAAGKQAK-DIKLTIYIPPSIKGGNVTTDISVLI 1561
Query: 184 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDAGKYVCVG 242
+EC+ RG P P I+W KDG P+ + + I +G L I + SD+ Y C
Sbjct: 1562 NSLIKLECET-RGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHV 1620
Query: 243 TNMVGERESEVAELTVLERPSF---VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 299
N+ G E + V P + P N V + S +C+A G+P P + W KD
Sbjct: 1621 ANVAGTAEKSF-HVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKAAGNPSPILTWLKD- 1678
Query: 300 GELPKSRYEIRDD---HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 356
G K+ IR + L+I D G Y CVA ++ G+ E + V PP ++
Sbjct: 1679 GVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPP--AIE 1736
Query: 357 PRDQ----VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG- 411
D+ +V + + C TG+P P I W ++G Q F + G
Sbjct: 1737 GGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDG--------QLIDERDGFKILLNGR 1788
Query: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471
L I Q S+ G Y C N AG K EVT + PP I+ +++ V V
Sbjct: 1789 KLVIAQAQVSNTGLYRCMAANTAGD--HKKEFEVTVHV----PPTIKSSGLSERVVVKYK 1842
Query: 472 FV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIAST 529
V L C+A G P P+I W KD V+T +K +G VLQI L D GRYTC+A+
Sbjct: 1843 PVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATN 1902
Query: 530 PSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN--LNS 587
+GE + V E + + ++ S P + E ++W + L S
Sbjct: 1903 AAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLS 1962
Query: 588 GATPTSYI 595
G+T +++
Sbjct: 1963 GSTSMTFL 1970
Score = 178 bits (452), Expect = 3e-44
Identities = 159/563 (28%), Positives = 236/563 (41%), Gaps = 59/563 (10%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP +++ P+++ V+ GE A L C + W + + R R+ P+
Sbjct: 519 PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQR----------NDRDVRLAEPARI 568
Query: 127 LFFLRIVHGRKSRP--DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA-- 182
+ KS D G Y C+ + E S AS+ + + Q P V V
Sbjct: 569 RTLANLSLELKSVKFNDAGEYHCMVSS---EGGSSAASVFLTV------QEPPKVTVMPK 619
Query: 183 ----VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKY 238
G V G+P+P I+W + + G L I DAG Y
Sbjct: 620 NQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTLFIKNAAPKDAGIY 679
Query: 239 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 298
C+ +N G + + + L +E P + S L V + D +C+ G P P V+W K
Sbjct: 680 GCLASNSAGT-DKQNSTLRYIEAPKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKG 738
Query: 299 DGELPKSRYEIRDD--HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 356
D EL S + I D LKI++ D G YTCVA N G+A TL V PP F+ +
Sbjct: 739 DLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINEAGRATGKITLDVGSPPVFIQE 798
Query: 357 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 416
P D + +G VT C G P+P I WRR + + + P S S S +TG L I
Sbjct: 799 PADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPI---FSRPFSVSSISQLRTGALFIL 855
Query: 417 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 476
N+ SD G YIC+ N G I ++ + VT ++A P+I P V L C
Sbjct: 856 NLWASDKGTYICEAENQFGKIQSETTVTVTGLVA----PLIGISPSVANVIEGQQLTLPC 911
Query: 477 -VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG--E 533
+ G+P+P W K+ ++ Q+ I +G L I +L D G YTC+AS +G
Sbjct: 912 TLLAGNPIPERRWIKNSAML-LQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNN 970
Query: 534 ATWSAYIEV-------QEF-----GVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 581
T S + V Q+ G+PV P N KP V + + +
Sbjct: 971 KTTSVVVHVLPTIQHGQQILSTIEGIPVTLPCKASGN------PKPSVIWSKKGELISTS 1024
Query: 582 QPNLNSGATPTSYIIEAFSHASG 604
++GA + Y++ SG
Sbjct: 1025 SAKFSAGADGSLYVVSPGGEESG 1047
Score = 177 bits (449), Expect = 8e-44
Identities = 140/468 (29%), Positives = 201/468 (42%), Gaps = 34/468 (7%)
Query: 75 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134
+D+ V L C+ G P P I WYK G+ + + S + + G +L I
Sbjct: 1555 TDISVLINSLIKLECETRGLPMPAITWYKDGQPIMSS-----SQALYIDKGQ--YLHIPR 1607
Query: 135 GRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQP 193
+ S D Y C N G A S + + V + + P + V + +EC+
Sbjct: 1608 AQVS--DSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNLATPLNKQVVIAHSLTLECKA 1665
Query: 194 PRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESE 252
G+P P ++W KDG P+ D RI G KL I ++ D G+Y+CV T++ GE+E +
Sbjct: 1666 A-GNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIK 1724
Query: 253 VAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIR 310
E+ VL P+ S V V++ E C G P PT+ W KD G+L R +
Sbjct: 1725 Y-EVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSPPPTIMWLKD-GQLIDERDGFK 1782
Query: 311 ---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP-RDQVVALGR 366
+ L I + + G Y C+A N G + +TV PP ++VV +
Sbjct: 1783 ILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYK 1842
Query: 367 TVTFQCEATGNPQPAIFWRREGSQ-NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 425
V QC A G P P+I W ++ N QSS R L I D G
Sbjct: 1843 PVALQCIANGIPNPSITWLKDDQPVNTAQGNLKIQSSGRV-------LQIAKTLLEDAGR 1895
Query: 426 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV-NQTVAVDGTFVLSCVATGSPVP 484
Y C N AG L V + PP + G + N+TV V L C A G+PVP
Sbjct: 1896 YTCVATNAAGETQQHIQLHVHE-----PPSLEDAGKMLNETVLVSNPVQLECKAAGNPVP 1950
Query: 485 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 532
I W KD L+S S ++ I A++ D G Y C+A +G
Sbjct: 1951 VITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAG 1998
Score = 177 bits (448), Expect = 1e-43
Identities = 136/473 (28%), Positives = 212/473 (44%), Gaps = 41/473 (8%)
Query: 75 SDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134
S+ +V K +P L C A G P P+I W K + V T + + + + SG + +
Sbjct: 1834 SERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLK----IQSSGRVLQI---- 1885
Query: 135 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM---VAVGEPAVMEC 191
+ D G Y CVA N GE H +++ + ++ ++ V V P +EC
Sbjct: 1886 AKTLLEDAGRYTCVATNAAGETQQH---IQLHVHEPPSLEDAGKMLNETVLVSNPVQLEC 1942
Query: 192 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLM-ITYTRKSDAGKYVCVGTNMVGERE 250
+ G+P P I+W KD L + G+++ I + SDAG Y CV N G E
Sbjct: 1943 KAA-GNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATE 2001
Query: 251 SEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE-- 308
+ L V PS + +AV V++ +CEARG P P++ W KD P S +
Sbjct: 2002 LFYS-LQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGS--PVSSFSNG 2058
Query: 309 ---IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALG 365
+ L + D G YTCVA N G+ + L V PP+ + + ++ V +
Sbjct: 2059 LQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIMGEEQNVSVLIS 2118
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVG 424
+ V C++ P P + W ++G P S+S+ L I + Q D G
Sbjct: 2119 QAVELLCQSDAIPPPTLTWLKDG--------HPLLKKPGLSISENRSVLKIEDAQVQDTG 2170
Query: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV-LSCVATGSPV 483
Y C+ NVAG T+ V + PP + + Q ++G + L C ++G P
Sbjct: 2171 RYTCEATNVAGK--TEKNYNVNIWV---PPNIGGSDELTQLTVIEGNLISLLCESSGIPP 2225
Query: 484 PTILWRKDGVLVSTQD-SRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGEA 534
P ++W+K G V T R++ L G LQI A+ D Y+C+AS +G A
Sbjct: 2226 PNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTA 2278
Score = 175 bits (443), Expect = 4e-43
Identities = 138/491 (28%), Positives = 211/491 (42%), Gaps = 40/491 (8%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP+I P L V G+ + C A+G P P I W KGG + D + H + P G+
Sbjct: 1170 PPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGE----HHVSNPDGT 1225
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLG----EAVSHNASLEVAILRDDFRQNPSDVMVA 182
L + + D G+Y CVA N G E H E + D +
Sbjct: 1226 LSI-----DQATPSDAGIYTCVATNIAGTDETEITLH--VQEPPTVEDLEPPYNTTFQER 1278
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI--RGGKLMITYTRKSDAGKYVC 240
V + P +G P+PTI W +G L ++ I+I G L+I D G+Y+C
Sbjct: 1279 VANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYIC 1338
Query: 241 VGTNMVGERESEVAELTVLERPSF--VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 298
V N G E + L V P ++ +N++V ++ CE G P P + W KD
Sbjct: 1339 VAVNEAGTTERKY-NLKVHVPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKD 1397
Query: 299 DGELPKSR--YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 356
+ ++ +S + + LK+ + T D G Y+C A N+ G ++ + V PP +
Sbjct: 1398 NVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGT 1457
Query: 357 --PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-L 413
P + V L R V +C+ G P P I W ++G LF P + G L
Sbjct: 1458 NFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKP--LFLGDP-----NVELLDRGQVL 1510
Query: 414 TITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ--TVAVDGT 471
+ N +R+D G Y C N AG L + PP I+ G V +V ++
Sbjct: 1511 HLKNARRNDKGRYQCTVSNAAGKQAKDIKLTI------YIPPSIKGGNVTTDISVLINSL 1564
Query: 472 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 531
L C G P+P I W KDG + + + + L I A++ D+ YTC + +
Sbjct: 1565 IKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSATYTCHVANVA 1624
Query: 532 GEATWSAYIEV 542
G A S +++V
Sbjct: 1625 GTAEKSFHVDV 1635
Score = 171 bits (432), Expect = 7e-42
Identities = 150/533 (28%), Positives = 237/533 (44%), Gaps = 67/533 (12%)
Query: 74 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 133
P ++ + TL C+A P+ ++ WYK G+ +++D H + +G L+I
Sbjct: 2681 PKEVKIKVNNTLTLECEAYAIPSASLSWYKDGQPLKSD-----DHVNIAANGHT--LQIK 2733
Query: 134 HGRKSRPDEGVYVCVARNYLGE-----------AVSHNASLEVAILRDDFRQNPSDVMVA 182
+ S D G Y CVA N GE S E+ + D R + ++
Sbjct: 2734 EAQIS--DTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVI- 2790
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCV 241
+ P + C+ P PT++W KDG PL D+ + + GG+ L I + DAG+Y CV
Sbjct: 2791 INNPISLYCET-NAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCV 2849
Query: 242 GTNMVGERESEVAELTVLERPSFVKR-----PSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
N GE +S ++ VL P +K P + V V+ SA +C + G P P W+
Sbjct: 2850 AVNEAGE-DSLQYDVRVLV-PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQ 2907
Query: 297 KDDGELPKSRYE--IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354
KD L + + + + L+I D+G Y CVAEN G A+ L V PP +
Sbjct: 2908 KDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVI 2967
Query: 355 -VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-D 412
K + V + ++ CE +G P P + W L + QP + ++ + G
Sbjct: 2968 GPKSENLTVVVNNFISLTCEVSGFPPPDLSW--------LKNEQPIKLNTNTLIVPGGRT 3019
Query: 413 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV---D 469
L I + SD G Y C +N AG K L V PP I+ V +
Sbjct: 3020 LQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY------VPPSIKDHDSESLSVVNVRE 3073
Query: 470 GTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIA 527
GT V L C + P P I W K+G ++ T+ + ++ L +G +L I+ A++ DTG+Y C A
Sbjct: 3074 GTSVSLECESNAVPPPVITWYKNGRMI-TESTHVEILADGQMLHIKKAEVSDTGQYVCRA 3132
Query: 528 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 580
+G + ++ V VP P++ P + + + N VTL+
Sbjct: 3133 INVAGRDDKNFHLNVY---VP--------PSI--EGPEREVIVETISNPVTLT 3172
Score = 170 bits (431), Expect = 9e-42
Identities = 143/500 (28%), Positives = 219/500 (43%), Gaps = 59/500 (11%)
Query: 67 PPRIVEH---PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 123
PP I+ + P ++ V + +L C+A G P P+I W+K G V S+ + +
Sbjct: 2383 PPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSL------SNSVRIL 2436
Query: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP-SDVMVA 182
SG LR++ + + D G Y CV RN GE L V + +N DV V
Sbjct: 2437 SGGRM-LRLM--QTTMEDAGQYTCVVRNAAGEE-RKIFGLSVLVPPHIVGENTLEDVKVK 2492
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCV 241
+ + C+ G+P P I+W KDG PL + + I GG+ L IT + G+Y C+
Sbjct: 2493 EKQSVTLTCEVT-GNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCL 2551
Query: 242 GTNMVGERESEVAELTVLERPSFVK-----RPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
++ G + S L V P+ P ++ V ++ CEA P T+ W
Sbjct: 2552 ASSPAGHK-SRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWF 2610
Query: 297 KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 353
KD L +R IR TL+I + G Y+CVA N G+ + V PP
Sbjct: 2611 KDGTPLESNR-NIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPII 2669
Query: 354 V--------VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRF 405
+ P++ + + T+T +CEA P ++ W ++G QP +S
Sbjct: 2670 NKGDLWGPGLSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDG--------QPLKSDDHV 2721
Query: 406 SVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN- 463
+++ G L I Q SD G Y C N+AG + L+ DV PP + +
Sbjct: 2722 NIAANGHTLQIKEAQISDTGRYTCVASNIAG----EDELDF-DVNIQVPPSFQKLWEIGN 2776
Query: 464 ----------QTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 513
+ V ++ L C +P PT+ W KDG +++ D + VLQI
Sbjct: 2777 MLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIP 2836
Query: 514 YAKLGDTGRYTCIASTPSGE 533
AK+ D GRYTC+A +GE
Sbjct: 2837 RAKVEDAGRYTCVAVNEAGE 2856
Score = 169 bits (428), Expect = 2e-41
Identities = 149/484 (30%), Positives = 216/484 (44%), Gaps = 44/484 (9%)
Query: 67 PPRIVEHPSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
PP ++ S+ L V +L C+ G P P + W K + ++ + ++ +++P G
Sbjct: 2963 PPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLN-----TNTLIVPGG 3017
Query: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVA 182
L+I+ + S D G Y C+A N GE+ SL V + ++D ++ S V V
Sbjct: 3018 RT--LQIIRAKVS--DGGEYTCIAINQAGES-KKKFSLTVYVPPSIKDHDSESLSVVNVR 3072
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCV 241
G +EC+ P P I+W K+G + + I G L I SD G+YVC
Sbjct: 3073 EGTSVSLECES-NAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCR 3131
Query: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAV-TVDDSAEFKCEARGDPVPTVRWRKDDG 300
N+ G R+ + L V PS + V T+ + C+A G P PT+ W K+
Sbjct: 3132 AINVAG-RDDKNFHLNVYVPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHK 3190
Query: 301 ELPKS-RYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVK 356
+ S E+R L+I + D G+YTC+A NM GKA+ L++Q PP
Sbjct: 3191 RIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGA 3250
Query: 357 --PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS--SSRFSVSQTGD 412
P D V LG V C A G P P I W ++G +P S + R VS G
Sbjct: 3251 EIPSDVSVLLGENVELVCNANGIPTPLIQWLKDG--------KPIASGETERIRVSANGS 3302
Query: 413 -LTITNVQRSDVGYYICQTLNVAG--SIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 469
L I SD G Y C N AG I + VT I + VD
Sbjct: 3303 TLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGN-----KDEAEKLMTLVD 3357
Query: 470 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIAS 528
+ + C ATG+P P I W K+G L S I+ L G V++I A++ D YTC+AS
Sbjct: 3358 TSINIECRATGTPPPQINWLKNG-LPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVAS 3416
Query: 529 TPSG 532
+G
Sbjct: 3417 NRAG 3420
Score = 163 bits (413), Expect = 1e-39
Identities = 140/498 (28%), Positives = 212/498 (42%), Gaps = 45/498 (9%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
P I + + V P L C+A G P P++ W K G V + + +L G +
Sbjct: 2012 PSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNG----LQVLSGGRI 2067
Query: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 187
L D G Y CVA N GE + L V + + +V V + +
Sbjct: 2068 LALT----SAQISDTGRYTCVAVNAAGEK-QRDIDLRVYV-PPNIMGEEQNVSVLISQAV 2121
Query: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVGTNMV 246
+ CQ P PT++W KDG PL K I+ L I + D G+Y C TN+
Sbjct: 2122 ELLCQSD-AIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVA 2180
Query: 247 GERESEV-AELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE-LPK 304
G+ E + V + L V + CE+ G P P + W+K L
Sbjct: 2181 GKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTD 2240
Query: 305 SRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV---VKPR 358
S +R L+I D Y+CVA N+ G A+ L V P P
Sbjct: 2241 SMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPT 2300
Query: 359 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITN 417
+ +V G++++ +CE G P P + W ++G P + + G L + N
Sbjct: 2301 EIIVTRGKSISLECEVQGIPPPTVTWMKDG--------HPLIKAKGVEILDEGHILQLKN 2352
Query: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI--RQGPVNQTVAVDGTFVLS 475
+ SD G Y+C +NVAG + K Y D+ PP +I + P N +V + L+
Sbjct: 2353 IHVSDTGRYVCVAVNVAG-MTDKKY----DLSVHAPPSIIGNHRSPENISVVEKNSVSLT 2407
Query: 476 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGEA 534
C A+G P+P+I W KDG VS +S ++ L G +L++ + D G+YTC+ +GE
Sbjct: 2408 CEASGIPLPSITWFKDGWPVSLSNS-VRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGE- 2465
Query: 535 TWSAYIEVQEFGVPVQPP 552
E + FG+ V P
Sbjct: 2466 ------ERKIFGLSVLVP 2477
Score = 160 bits (405), Expect = 1e-38
Identities = 138/525 (26%), Positives = 214/525 (40%), Gaps = 62/525 (11%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKA-EGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
P I PS V +G+ TL C G P P W K + + + + GS
Sbjct: 890 PLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNP-----YITVRSDGS 944
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV-GE 185
L R+ D G Y CVA N G ++N + V + Q+ ++ + G
Sbjct: 945 LHIERV-----QLQDGGEYTCVASNVAG---TNNKTTSVVVHVLPTIQHGQQILSTIEGI 996
Query: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GKLMITYTRKSDAGKYVCVGTN 244
P + C+ G+P+P++ W K G + + + G L + ++G+YVC TN
Sbjct: 997 PVTLPCKAS-GNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATN 1055
Query: 245 MVGERESEVAELTVLERPSFV--------KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
G + +V +LTV RP +P ++V + CE + P P + W
Sbjct: 1056 TAGYAKRKV-QLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEVKSLPPPIITWA 1114
Query: 297 KDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354
K+ + R+ ++KI + D G Y CVA N+ G + L V PP
Sbjct: 1115 KETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVPPKIQ 1174
Query: 355 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414
P+ V +G+ V C A G P P I W + GS L+ + G L+
Sbjct: 1175 RGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLV-------DGEHHVSNPDGTLS 1227
Query: 415 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD--VIADRPPP---VIRQGPVNQTVAVD 469
I SD G Y C N+AG+ T+ L V + + D PP ++ NQ +
Sbjct: 1228 IDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVANQRIE-- 1285
Query: 470 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIAS 528
C A G+P PTI W +G ++ ++ I LE+G +L I D G Y C+A
Sbjct: 1286 ----FPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAV 1341
Query: 529 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS 573
+G +++ + V P P K +VT+VS
Sbjct: 1342 NEAGTTE-------RKYNLKVHVP--------PVIKDKEQVTNVS 1371
Score = 160 bits (405), Expect = 1e-38
Identities = 140/481 (29%), Positives = 201/481 (41%), Gaps = 34/481 (7%)
Query: 67 PPRIV--EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP + E PSD+ V GE L C A G PTP I+W K G+ + + + + + S
Sbjct: 3244 PPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETE-----RIRVS 3298
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVS-HNASLEVAILRDDFRQNPSDVMVAV 183
+ L I S D G Y CVA N GE N ++ V + +M V
Sbjct: 3299 ANGSTLNIYGALTS--DTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLV 3356
Query: 184 GEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRGGKLMITYTRKSDAGKYVCVG 242
+EC+ G P P I+W K+G PL R+ G + I + SD Y CV
Sbjct: 3357 DTSINIECR-ATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVA 3415
Query: 243 TNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWRKDDG 300
+N G +++ L V P+ +TV S C G P P++ W +D
Sbjct: 3416 SNRAGV-DNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQ 3474
Query: 301 ELPKSRYEIRDDH--TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
L + H L++ K D G YTC+A N G+ L V EPPH
Sbjct: 3475 PLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEE 3534
Query: 359 DQVVA--LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 416
+ ++ + + C A+G P P + W ++G PQ+ ++ L I+
Sbjct: 3535 HEEISVIVNNPLELTCIASGIPAPKMTWMKDGR-------PLPQTDQVQTLGGGEVLRIS 3587
Query: 417 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI-RQGPVNQTVAVDGTFVLS 475
Q D G Y C + AG K YL V PP + P + TV + L
Sbjct: 3588 TAQVEDTGRYTCLASSPAGD-DDKEYLVRVHV----PPNIAGTDEPRDITVLRNRQVTLE 3642
Query: 476 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGEA 534
C + P P I W ++G + R++ L G LQI A LGDT YTC+AS +G+
Sbjct: 3643 CKSDAVPPPVITWLRNGERLQA-TPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKT 3701
Query: 535 T 535
T
Sbjct: 3702 T 3702
Score = 82.8 bits (203), Expect = 3e-15
Identities = 59/218 (27%), Positives = 84/218 (38%), Gaps = 13/218 (5%)
Query: 315 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 374
L I KVT D G Y C+A + G A V EPP + P + V G C
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEPPPVIQVPNNVTVTPGERAVLTCLI 543
Query: 375 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVA 434
+ W+R L +R L + +V+ +D G Y C +
Sbjct: 544 ISAVDYNLTWQRNDRDVRL------AEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEG 597
Query: 435 GSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVL 494
GS +L V + PP + P NQ+ + C ATG P P I W + +
Sbjct: 598 GSSAASVFLTVQE------PPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMF 651
Query: 495 VSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 532
+ R + +G L I+ A D G Y C+AS +G
Sbjct: 652 I-VGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAG 688
Score = 68.2 bits (165), Expect = 6e-11
Identities = 47/149 (31%), Positives = 75/149 (50%), Gaps = 13/149 (8%)
Query: 408 SQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 467
S + +L I V SD G+Y C ++ AG+ + + +V++ PPPVI Q P N TV
Sbjct: 479 SASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE-----PPPVI-QVPNNVTVT 532
Query: 468 VDGTFVLSCVATGSPVPTILW-RKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 526
VL+C+ + + W R D + + +RI+ L N L+++ K D G Y C+
Sbjct: 533 PGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCM 592
Query: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 555
S+ G + S ++ VQE PP+ T
Sbjct: 593 VSSEGGSSAASVFLTVQE------PPKVT 615
Score = 34.7 bits (78), Expect = 0.79
Identities = 28/103 (27%), Positives = 44/103 (42%), Gaps = 9/103 (8%)
Query: 485 TILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQE 544
T+ + ++GV + D +K+ + L I L D G Y CIA + +G + +V E
Sbjct: 460 TLSFVRNGVTLGV-DQYLKESASVNLDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE 518
Query: 545 FGVPVQPPRPTDPNLIPSAPSKPEVTD---VSRNTVTLSWQPN 584
PP PN + P + V +S L+WQ N
Sbjct: 519 -----PPPVIQVPNNVTVTPGERAVLTCLIISAVDYNLTWQRN 556
>gi|7657359 contactin 5 isoform long [Homo sapiens]
Length = 1100
Score = 219 bits (558), Expect = 2e-56
Identities = 225/855 (26%), Positives = 339/855 (39%), Gaps = 82/855 (9%)
Query: 65 DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
D+ P V+ P D+I S + LNC+ G P P+ W + G ++ + D +R
Sbjct: 96 DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 151
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181
L G+ I+ D G Y C+A N +G +S A+L+ A L + + S V V
Sbjct: 152 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 207
Query: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 238
G+ V+ C PP PE SW + P +D I+ G L I+ + SD G Y
Sbjct: 208 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 267
Query: 239 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 288
+C+ N V S LT+ E V P + + + +C A G+
Sbjct: 268 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 327
Query: 289 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348
PVPT+ W K +G +P + L+I V D G Y C AEN GK L V
Sbjct: 328 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 387
Query: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
PH+V K D + G + ++C+ATG P+P W + G P SR +
Sbjct: 388 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRVEM- 438
Query: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468
G L I NV +SD G Y C N G+I A L+ ++A P + Q V
Sbjct: 439 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTIIVTK 495
Query: 469 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 528
D V+ C GSP PTI W+K G ++ RI L +G L+I A D G+Y C
Sbjct: 496 DQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE 554
Query: 529 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 588
G A A + V+E P I P + E+T ++ L+ + ++
Sbjct: 555 NVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIHDAS 600
Query: 589 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648
T Y E+++ + S+ + N L+ A YG
Sbjct: 601 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG------- 649
Query: 649 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYK 708
+ Q + V+ G + + S++++ D S I Y
Sbjct: 650 ---CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-ISSYN 705
Query: 709 ILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--SEIK 766
+ R + ++ V E+ T S + DL V YE + N D + +
Sbjct: 706 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPSTPSR 764
Query: 767 FAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHI 826
+T E P P VS G ++++W+P E+ QNG Y V N TR
Sbjct: 765 MIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK 822
Query: 827 NKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP-VS 879
K V S S I P L P + V+V G G S+ I A G P +
Sbjct: 823 EKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEPSAA 878
Query: 880 PEDQVSLAQQISDVV 894
P D + + +S+++
Sbjct: 879 PTDVKATSVSVSEIL 893
Score = 175 bits (443), Expect = 4e-43
Identities = 205/765 (26%), Positives = 303/765 (39%), Gaps = 106/765 (13%)
Query: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 191
D G Y+C+ +N + A + + + D P V A G MEC
Sbjct: 263 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 322
Query: 192 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
G+P PTI+W K + K R+ L I + DAG Y C N G + S
Sbjct: 323 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 379
Query: 252 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 310
+L V P +V++ ++ + ++C+A G P PT RW K+ L P+SR E+
Sbjct: 380 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 439
Query: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPHFVVKPRDQ--VVALGRT 367
+ L I V D G Y C+AEN G ASA L + P F + + +V +
Sbjct: 440 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE 498
Query: 368 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 427
V +C+ G+P+P I W++ + + + R ++ G L I N +SD G Y+
Sbjct: 499 VVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGKYV 550
Query: 428 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPVPT 485
C+ NV GS A L V + P I P + V + VL+C A S T
Sbjct: 551 CRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 604
Query: 486 ILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 539
W G + ++ S Q + L IR L GRY C T + + A
Sbjct: 605 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 664
Query: 540 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 599
+ V+ PP P P V +++ +T TLSW P ++ + +SY ++A
Sbjct: 665 LLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 709
Query: 600 SHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQISD 650
S S WQT VKT I G L P Y F V A N G DPS S
Sbjct: 710 SPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSR 764
Query: 651 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ-- 705
++T + +P + PT +S S H V + S+ Q
Sbjct: 765 MIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQNG 804
Query: 706 ---GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEFQG 760
GY + +RP+G W V + + + D + +E+K + N+ G
Sbjct: 805 EGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG 860
Query: 761 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-CLG 819
S+I + E PSA P V + + ILV+W+ E E W +
Sbjct: 861 PFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME 918
Query: 820 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 864
E KT +F V++ L Y V A GAG G S
Sbjct: 919 QEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 962
Score = 158 bits (400), Expect = 4e-38
Identities = 206/851 (24%), Positives = 338/851 (39%), Gaps = 106/851 (12%)
Query: 43 PIPTSDNDDNSLGYTGSRLRQEDFPPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEW 101
P P + +D +G ++ P+I H P + +KG + C A G P PTI W
Sbjct: 284 PTPLTLRNDGVMG---------EYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW 334
Query: 102 YKGGERVETDKDDPRSHRML-LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHN 160
K + + +S +L +P+ L D G+Y C A N G+ S
Sbjct: 335 MKVNGYIPSKARLRKSQAVLEIPNVQL------------DDAGIYECRAENSRGKN-SFR 381
Query: 161 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 220
L+V + + +D + G P EC+ G P PT W K+G PL + R+ +
Sbjct: 382 GQLQVYTY-PHWVEKLNDTQLDSGSPLRWECKAT-GKPRPTYRWLKNGVPLSPQS-RVEM 438
Query: 221 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL-ERPSFV--KRPSNLAVTVDD 277
G LMI +SDAG Y C+ N G + AEL +L P+F + + VT D
Sbjct: 439 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYAS-AELKILASAPTFALNQLKKTIIVTKDQ 497
Query: 278 SAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 336
+C+ +G P PT+ W+K D + ++ R I D +L+I + D G Y C EN+
Sbjct: 498 EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVF 557
Query: 337 GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA--TGNPQPAIFWRREGSQNLLF 394
G AE A+L+V+EP + P+ + +G ++ C+A + +W +G Q + F
Sbjct: 558 GSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKG-QPIDF 616
Query: 395 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454
+ S + + + DL I N+ G Y C+ A S+ +A L V PP
Sbjct: 617 EEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG--PPGPP 674
Query: 455 PVIRQGPVNQTVAVDGTFVLSCVATG-SPVPTI-LWRKDGVLVSTQDSR-IKQLENGVLQ 511
++ + ++ A T S A SP+ + L + + Q + + ++ G ++
Sbjct: 675 GIVIVEEITESTA---TLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDME 731
Query: 512 IRYA-KLGDTGRY--TCIASTPSGEATWSAYIEVQEFGVPVQPPR--PTDPNLIPSAPSK 566
A L Y +A+ P G G P P R T+ + +AP+
Sbjct: 732 SAMAVDLNPWVEYEFRVVATNPIGT------------GDPSTPSRMIRTNEAVPKTAPTN 779
Query: 567 PEVTDVSRNTVTLSWQPNLNSGATPTSY-IIEAFSHASGSSWQTVAENVKTETSAIK--- 622
R+ + ++W+P + I AF W+ E + T + A K
Sbjct: 780 VSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK---EKMVTSSEASKFIY 836
Query: 623 ---GLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 679
+ P + V N G SQI + + + P++ D K
Sbjct: 837 RDESVPPLTPFEVKVGVYNNKGDGPFSQIV-VICSAEGEPSAAPTDVK------------ 883
Query: 680 LHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHG-----ESDWLVFEVRTPAKN 734
T +S S I V W ++S L RP G G E + V+T
Sbjct: 884 ---ATSVSVSEILVAWKHIKES--------LGRPQGFEVGYWKDMEQEDTAETVKTRGNE 932
Query: 735 S-VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTA 793
S V++ L Y R + G S A T + PS P + + + G+
Sbjct: 933 SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNL---RWEQQGSQ 989
Query: 794 ILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVA 853
+ + W+P V YKV+ + + ++ ++ V+P G+ Y +EV
Sbjct: 990 VSLGWEPVIPLANESEVVGYKVFY--RQEGHSNSQVIETQKLQAVVPLPDAGV-YIIEVR 1046
Query: 854 ASTGAGSGVKS 864
A + G G S
Sbjct: 1047 AYSEGGDGTAS 1057
Score = 129 bits (323), Expect = 3e-29
Identities = 190/794 (23%), Positives = 312/794 (39%), Gaps = 113/794 (14%)
Query: 119 RMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN--- 175
R+ S S F R S P G + ++LG A ++ + + + D F+Q+
Sbjct: 36 RIKKSSSSSLFGSKTRPRYSSPSLGTLSASSPSWLGAAQNYYSPINLYHSSDAFKQDESV 95
Query: 176 ---------PSDVMVAVG---EPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITIRG 222
P D++ + + C+ RG+P P+ W ++G+ +D + D R ++
Sbjct: 96 DYGPVFVQEPDDIIFPTDSDEKKVALNCE-VRGNPVPSYRWLRNGTEIDLESDYRYSLID 154
Query: 223 GKLMITY-TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 281
G +I+ + D+G Y C+ TN VG S A L +F R + AV+V +
Sbjct: 155 GTFIISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGR-TRSAVSVREGQGV 213
Query: 282 KCEARGDP-VPTVRWRKDDGELP------KSRYEIRDDHTLKIRKVTAGDMGSYTCVAEN 334
P P + + E P R+ ++ L I KV D+GSY C+ +N
Sbjct: 214 VLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSYICLVKN 273
Query: 335 MVGKAEA---SATLTVQ--------EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIF 383
V A LT++ EP V P A G TV +C A GNP P I
Sbjct: 274 TVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTIT 333
Query: 384 WRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYL 443
W + + Y P S +R SQ L I NVQ D G Y C+ N G + L
Sbjct: 334 WMK------VNGYIP--SKARLRKSQ-AVLEIPNVQLDDAGIYECRAENSRGKNSFRGQL 384
Query: 444 EVTDVIADRPPPVIRQGPVNQTVAVDGT-FVLSCVATGSPVPTILWRKDGVLVSTQDSRI 502
+V P + + +N T G+ C ATG P PT W K+GV +S Q SR+
Sbjct: 385 QVYTY-----PHWVEK--LNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQ-SRV 436
Query: 503 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS 562
++ NGVL I D G Y C+A G SA +++ + S
Sbjct: 437 -EMVNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELKI-----------------LAS 478
Query: 563 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE----- 617
AP+ + + T+ ++ + P S G + V EN +
Sbjct: 479 APT--FALNQLKKTIIVTKDQEVVIECKPQGSPKPTISWKKGD--RAVRENKRIAILPDG 534
Query: 618 TSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAV 677
+ I + ++ R N +G ++I + ++ PT + K+ + +G ++
Sbjct: 535 SLRILNASKSDEGKYVCRGENVFG---SAEIIASLSVKE--PTRIELTPKRTELTVGESI 589
Query: 678 LHLHNPTVLSSSSIEV--HWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNS 735
+ N + +S++V +WT ++G I + G + +N
Sbjct: 590 --VLNCKAIHDASLDVTFYWT-------LKGQPIDFEEEGGHFESIRAQASSADLMIRNI 640
Query: 736 VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAIL 795
+++ R G + ADS A+ L P PP G+ + + TA L
Sbjct: 641 LLMHAGRYGCRVQTT----------ADSVSDEAELLVRGPPGPP-GIVIVEEITESTATL 689
Query: 796 VSWQPPPED---TQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 852
SW P ++ + +Q + LG +T + + + G S + L P + Y V
Sbjct: 690 -SWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV 748
Query: 853 AASTGAGSGVKSEP 866
A+ G+G S P
Sbjct: 749 VATNPIGTGDPSTP 762
>gi|28373129 contactin 5 isoform short [Homo sapiens]
Length = 1026
Score = 219 bits (558), Expect = 2e-56
Identities = 225/855 (26%), Positives = 339/855 (39%), Gaps = 82/855 (9%)
Query: 65 DFPPRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
D+ P V+ P D+I S + LNC+ G P P+ W + G ++ + D +R
Sbjct: 22 DYGPVFVQEPDDIIFPTDSDEKKVALNCEVRGNPVPSYRWLRNGTEIDLESD----YRYS 77
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181
L G+ I+ D G Y C+A N +G +S A+L+ A L + + S V V
Sbjct: 78 LIDGTF----IISNPSEAKDSGHYQCLATNTVGSILSREATLQFAYLGNFSGRTRSAVSV 133
Query: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKY 238
G+ V+ C PP PE SW + P +D I+ G L I+ + SD G Y
Sbjct: 134 REGQGVVLMCSPPPHSPEIIYSWVFNEFPSFVAEDSRRFISQETGNLYISKVQTSDVGSY 193
Query: 239 VCVGTNMVGERE--SEVAELTV--------LERPSFVKRPSNLAVTVDDSAEFKCEARGD 288
+C+ N V S LT+ E V P + + + +C A G+
Sbjct: 194 ICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMECFALGN 253
Query: 289 PVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348
PVPT+ W K +G +P + L+I V D G Y C AEN GK L V
Sbjct: 254 PVPTITWMKVNGYIPSKARLRKSQAVLEIPNVQLDDAGIYECRAENSRGKNSFRGQLQVY 313
Query: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
PH+V K D + G + ++C+ATG P+P W + G P SR +
Sbjct: 314 TYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNG--------VPLSPQSRVEM- 364
Query: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468
G L I NV +SD G Y C N G+I A L+ ++A P + Q V
Sbjct: 365 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYASAELK---ILASAPTFALNQLKKTIIVTK 421
Query: 469 DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 528
D V+ C GSP PTI W+K G ++ RI L +G L+I A D G+Y C
Sbjct: 422 DQEVVIECKPQGSPKPTISWKK-GDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGE 480
Query: 529 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 588
G A A + V+E P I P + E+T ++ L+ + ++
Sbjct: 481 NVFGSAEIIASLSVKE------------PTRIELTPKRTELT--VGESIVLNCKAIHDAS 526
Query: 589 ATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQI 648
T Y E+++ + S+ + N L+ A YG
Sbjct: 527 LDVTFYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRN----ILLMHAGRYG------- 575
Query: 649 SDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYK 708
+ Q + V+ G + + S++++ D S I Y
Sbjct: 576 ---CRVQTTADSVSDEAELLVRGPPGPPGIVIVEEITESTATLSWSPAADNHSP-ISSYN 631
Query: 709 ILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD--SEIK 766
+ R + ++ V E+ T S + DL V YE + N D + +
Sbjct: 632 LQARSPFSLGWQTVKTVPEIITGDMESAMAVDLNPWVEYEFRV-VATNPIGTGDPSTPSR 690
Query: 767 FAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHI 826
+T E P P VS G ++++W+P E+ QNG Y V N TR
Sbjct: 691 MIRTNEAVPKTAP--TNVSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK 748
Query: 827 NKTVDGSTFSVVI------PFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNP-VS 879
K V S S I P L P + V+V G G S+ I A G P +
Sbjct: 749 EKMVTSSEASKFIYRDESVPPLTP---FEVKVGVYNNKGDGPFSQIVVI-CSAEGEPSAA 804
Query: 880 PEDQVSLAQQISDVV 894
P D + + +S+++
Sbjct: 805 PTDVKATSVSVSEIL 819
Score = 175 bits (443), Expect = 4e-43
Identities = 205/765 (26%), Positives = 303/765 (39%), Gaps = 106/765 (13%)
Query: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN---------PSDVMVAVGEPAVMEC 191
D G Y+C+ +N + A + + + D P V A G MEC
Sbjct: 189 DVGSYICLVKNTVTNARVLSPPTPLTLRNDGVMGEYEPKIEVHFPFTVTAAKGTTVKMEC 248
Query: 192 QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
G+P PTI+W K + K R+ L I + DAG Y C N G + S
Sbjct: 249 FA-LGNPVPTITWMKVNGYIPSK-ARLRKSQAVLEIPNVQLDDAGIYECRAENSRG-KNS 305
Query: 252 EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIR 310
+L V P +V++ ++ + ++C+A G P PT RW K+ L P+SR E+
Sbjct: 306 FRGQLQVYTYPHWVEKLNDTQLDSGSPLRWECKATGKPRPTYRWLKNGVPLSPQSRVEMV 365
Query: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPHFVVKPRDQ--VVALGRT 367
+ L I V D G Y C+AEN G ASA L + P F + + +V +
Sbjct: 366 NG-VLMIHNVNQSDAGMYQCLAENKYGAIYASAELKILASAPTFALNQLKKTIIVTKDQE 424
Query: 368 VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYI 427
V +C+ G+P+P I W++ + + + R ++ G L I N +SD G Y+
Sbjct: 425 VVIECKPQGSPKPTISWKKGD--------RAVRENKRIAILPDGSLRILNASKSDEGKYV 476
Query: 428 CQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT--GSPVPT 485
C+ NV GS A L V + P I P + V + VL+C A S T
Sbjct: 477 CRGENVFGSAEIIASLSVKE------PTRIELTPKRTELTVGESIVLNCKAIHDASLDVT 530
Query: 486 ILWRKDGVLVSTQD------SRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAY 539
W G + ++ S Q + L IR L GRY C T + + A
Sbjct: 531 FYWTLKGQPIDFEEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAE 590
Query: 540 IEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF 599
+ V+ PP P P V +++ +T TLSW P ++ + +SY ++A
Sbjct: 591 LLVRG------PPGP---------PGIVIVEEITESTATLSWSPAADNHSPISSYNLQAR 635
Query: 600 SHASGSSWQTVAENVKTETSAIKG---------LKPNAIYLFLVRAANAYGISDPSQISD 650
S S WQT VKT I G L P Y F V A N G DPS S
Sbjct: 636 SPFS-LGWQT----VKTVPEIITGDMESAMAVDLNPWVEYEFRVVATNPIGTGDPSTPSR 690
Query: 651 PVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQ-- 705
++T + +P + PT +S S H V + S+ Q
Sbjct: 691 MIRTNEAVPKTA--------------------PTNVSGRSGRRHELVIAWEPVSEEFQNG 730
Query: 706 ---GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD--LRKGVNYEIKARPFFNEFQG 760
GY + +RP+G W V + + + D + +E+K + N+ G
Sbjct: 731 EGFGYIVAFRPNGTR----GWKEKMVTSSEASKFIYRDESVPPLTPFEVKVGVYNNKGDG 786
Query: 761 ADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVW-CLG 819
S+I + E PSA P V + + ILV+W+ E E W +
Sbjct: 787 PFSQIVVICSAEGEPSAAP--TDVKATSVSVSEILVAWKHIKESLGRPQGFEVGYWKDME 844
Query: 820 NETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 864
E KT +F V++ L Y V A GAG G S
Sbjct: 845 QEDTAETVKTRGNESF-VILTGLEGNTLYHFTVRAYNGAGYGPPS 888
Score = 158 bits (400), Expect = 4e-38
Identities = 206/851 (24%), Positives = 338/851 (39%), Gaps = 106/851 (12%)
Query: 43 PIPTSDNDDNSLGYTGSRLRQEDFPPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEW 101
P P + +D +G ++ P+I H P + +KG + C A G P PTI W
Sbjct: 210 PTPLTLRNDGVMG---------EYEPKIEVHFPFTVTAAKGTTVKMECFALGNPVPTITW 260
Query: 102 YKGGERVETDKDDPRSHRML-LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHN 160
K + + +S +L +P+ L D G+Y C A N G+ S
Sbjct: 261 MKVNGYIPSKARLRKSQAVLEIPNVQL------------DDAGIYECRAENSRGKN-SFR 307
Query: 161 ASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI 220
L+V + + +D + G P EC+ G P PT W K+G PL + R+ +
Sbjct: 308 GQLQVYTY-PHWVEKLNDTQLDSGSPLRWECKAT-GKPRPTYRWLKNGVPLSPQS-RVEM 364
Query: 221 RGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL-ERPSFV--KRPSNLAVTVDD 277
G LMI +SDAG Y C+ N G + AEL +L P+F + + VT D
Sbjct: 365 VNGVLMIHNVNQSDAGMYQCLAENKYGAIYAS-AELKILASAPTFALNQLKKTIIVTKDQ 423
Query: 278 SAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMV 336
+C+ +G P PT+ W+K D + ++ R I D +L+I + D G Y C EN+
Sbjct: 424 EVVIECKPQGSPKPTISWKKGDRAVRENKRIAILPDGSLRILNASKSDEGKYVCRGENVF 483
Query: 337 GKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA--TGNPQPAIFWRREGSQNLLF 394
G AE A+L+V+EP + P+ + +G ++ C+A + +W +G Q + F
Sbjct: 484 GSAEIIASLSVKEPTRIELTPKRTELTVGESIVLNCKAIHDASLDVTFYWTLKG-QPIDF 542
Query: 395 SYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454
+ S + + + DL I N+ G Y C+ A S+ +A L V PP
Sbjct: 543 EEEGGHFESIRAQASSADLMIRNILLMHAGRYGCRVQTTADSVSDEAELLVRG--PPGPP 600
Query: 455 PVIRQGPVNQTVAVDGTFVLSCVATG-SPVPTI-LWRKDGVLVSTQDSR-IKQLENGVLQ 511
++ + ++ A T S A SP+ + L + + Q + + ++ G ++
Sbjct: 601 GIVIVEEITESTA---TLSWSPAADNHSPISSYNLQARSPFSLGWQTVKTVPEIITGDME 657
Query: 512 IRYA-KLGDTGRY--TCIASTPSGEATWSAYIEVQEFGVPVQPPR--PTDPNLIPSAPSK 566
A L Y +A+ P G G P P R T+ + +AP+
Sbjct: 658 SAMAVDLNPWVEYEFRVVATNPIGT------------GDPSTPSRMIRTNEAVPKTAPTN 705
Query: 567 PEVTDVSRNTVTLSWQPNLNSGATPTSY-IIEAFSHASGSSWQTVAENVKTETSAIK--- 622
R+ + ++W+P + I AF W+ E + T + A K
Sbjct: 706 VSGRSGRRHELVIAWEPVSEEFQNGEGFGYIVAFRPNGTRGWK---EKMVTSSEASKFIY 762
Query: 623 ---GLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 679
+ P + V N G SQI + + + P++ D K
Sbjct: 763 RDESVPPLTPFEVKVGVYNNKGDGPFSQIV-VICSAEGEPSAAPTDVK------------ 809
Query: 680 LHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHG-----ESDWLVFEVRTPAKN 734
T +S S I V W ++S L RP G G E + V+T
Sbjct: 810 ---ATSVSVSEILVAWKHIKES--------LGRPQGFEVGYWKDMEQEDTAETVKTRGNE 858
Query: 735 S-VVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTA 793
S V++ L Y R + G S A T + PS P + + + G+
Sbjct: 859 SFVILTGLEGNTLYHFTVRAYNGAGYGPPSSEVSATTKKSPPSQAPSNL---RWEQQGSQ 915
Query: 794 ILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVA 853
+ + W+P V YKV+ + + ++ ++ V+P G+ Y +EV
Sbjct: 916 VSLGWEPVIPLANESEVVGYKVFY--RQEGHSNSQVIETQKLQAVVPLPDAGV-YIIEVR 972
Query: 854 ASTGAGSGVKS 864
A + G G S
Sbjct: 973 AYSEGGDGTAS 983
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 208 bits (530), Expect = 3e-53
Identities = 149/478 (31%), Positives = 215/478 (44%), Gaps = 31/478 (6%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
P + PS + E L C+A G P PTI W K G V T +LP G L
Sbjct: 2666 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 2720
Query: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 187
RI H S D G Y+C+A+N G A+ V + D+ G A
Sbjct: 2721 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 2773
Query: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 246
+ C+ RG PEP I+W KDG P+ + + TI+ G+L++ DAG Y C N V
Sbjct: 2774 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2832
Query: 247 GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 306
G V LT+L P F P + ++ + D +C ARG P P + W +D + +
Sbjct: 2833 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2891
Query: 307 YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA-LG 365
E TL+ V+ D G+Y C AEN VG+ +A + + V+E P + +V +G
Sbjct: 2892 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 2951
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 425
++ C G+P P I W ++G P + S Q G LTI +R D G
Sbjct: 2952 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIRRTERDDAGR 3003
Query: 426 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 485
Y C N G + K + ++ + PV + P + TV L C ATG P PT
Sbjct: 3004 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 3057
Query: 486 ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
I W + G + R++ L +G L + + GD G Y C+A G AT A++ V+
Sbjct: 3058 IEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3114
Score = 196 bits (498), Expect = 2e-49
Identities = 162/531 (30%), Positives = 232/531 (43%), Gaps = 47/531 (8%)
Query: 44 IPTSDNDD------NSLGYTGSRLRQEDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPT 96
+ T+D+ D N+ G T R E P I P + VS + A L C+A+G P
Sbjct: 2360 LSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA 2419
Query: 97 PTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEA 156
P + W K +RV D PR +LP GSL ++ D G Y+C+A N G
Sbjct: 2420 PLVSWRK--DRVPLDPRSPRFE--ILPEGSLRIQPVL-----AQDAGHYLCLASNSAG-- 2468
Query: 157 VSHNASLEVAILRDD-FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD 215
S ++ +L +PS++ + PA++ C+ G P+P + W KDG LD +
Sbjct: 2469 -SDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKLDFRL 2526
Query: 216 ERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLA 272
++ R L++T D+ ++ CV +N VGE + ++TV P+ ++
Sbjct: 2527 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH-RLYQVTVHVPPTIADDQTDFT 2585
Query: 273 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTC 330
VT+ C + G P PTV W K +L S Y + L+I + G YTC
Sbjct: 2586 VTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTC 2645
Query: 331 VAENMVGKAEASATLTVQEPPHFVVKPRDQVV--ALGRTVTFQCEATGNPQPAIFWRREG 388
A N G A LTVQ P VVKP VV V CEA+G P+P I W++EG
Sbjct: 2646 SARNSAGVAHKHVFLTVQASP--VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 2703
Query: 389 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 448
+ V G L I + D G Y+C N AGS + K L V
Sbjct: 2704 LN--------VATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV--- 2752
Query: 449 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG 508
+ PPVI G + + L C A GSP P I W KDG VS + + +G
Sbjct: 2753 ---QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG 2809
Query: 509 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL 559
L ++ + D G YTC A G A ++ + +PV P D +L
Sbjct: 2810 ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI--LVLPVFTTLPGDRSL 2858
Score = 192 bits (489), Expect = 2e-48
Identities = 158/510 (30%), Positives = 222/510 (43%), Gaps = 49/510 (9%)
Query: 67 PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 123
PP I + L+ GE T+ C G P + W K G + P S R LL
Sbjct: 2028 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 2080
Query: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 180
GS LRI + D G++ CVA + G A N +L+V + L QN DV+
Sbjct: 2081 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 2135
Query: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 240
V G + C+ RG P P +SW KDG PL + +G L + D+G Y C
Sbjct: 2136 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 2191
Query: 241 VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 298
V + GE +LTV+E P +P+ L++T E C+A+G P P + W KD
Sbjct: 2192 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 2250
Query: 299 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
L + R L++R D G YTC+AE+ G E S + VQ PP+ +V PR
Sbjct: 2251 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 2304
Query: 359 DQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 415
+G + +C P P I W R+G ++ RF L +
Sbjct: 2305 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQL 2357
Query: 416 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 475
+ +D G Y C N AGS +E+ V P IR GP V+V+ T +L
Sbjct: 2358 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLP 2411
Query: 476 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 535
C A G P P + WRKD V + + R + L G L+I+ D G Y C+AS +G
Sbjct: 2412 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 2471
Query: 536 WSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 565
+ V E P P P++ L P+
Sbjct: 2472 QGRDLRVLE--PPAIAPSPSNLTLTAHTPA 2499
Score = 186 bits (472), Expect = 2e-46
Identities = 156/542 (28%), Positives = 231/542 (42%), Gaps = 56/542 (10%)
Query: 67 PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I + P++L ++ G P L C A+G P P I W+K G+ + +++ R+ R+L
Sbjct: 2211 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 2270
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
D G+Y C+A + G S V + P VG
Sbjct: 2271 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 2311
Query: 185 ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 240
V+EC P P I+W +DG L +D + RG L + +D+G Y C
Sbjct: 2312 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 2370
Query: 241 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300
N G S + + P+ P + V+V+ +A C+A G P P V WRKD
Sbjct: 2371 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 2429
Query: 301 EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
L P+S R+EI + +L+I+ V A D G Y C+A N G L V EPP P
Sbjct: 2430 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2489
Query: 359 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 418
+ + CEA+G+P+P + W ++G Q L F Q + + + L +T
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAP 2544
Query: 419 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 478
D + C N G + Y V PP I + TV + VL+C +
Sbjct: 2545 GPQDSAQFECVVSNEVGE-AHRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLTCHS 2598
Query: 479 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 538
TG P PT+ W K G + + S + +G L+I A GRYTC A +G A
Sbjct: 2599 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHV 2658
Query: 539 YIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 591
++ VQ PV P P+ + L+P E + + R T+T WQ + AT
Sbjct: 2659 FLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNVATG 2709
Query: 592 TS 593
S
Sbjct: 2710 VS 2711
Score = 184 bits (466), Expect = 8e-46
Identities = 168/527 (31%), Positives = 234/527 (44%), Gaps = 71/527 (13%)
Query: 86 TLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVY 145
TL C++ P PTI WYK G+ V P S +L G L L+I + S D G Y
Sbjct: 1376 TLECESWAVPPPTIRWYKDGQPVT-----PSSRLQVLGEGRL--LQIQPTQVS--DSGRY 1426
Query: 146 VCVARNYLGE-----------------AVSHNASLEVAILRDDFRQNPSDVMVAV-GEPA 187
+CVA N GE +A+ E+ ++ R ++ V PA
Sbjct: 1427 LCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPA 1486
Query: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMV 246
+ C P P ++W ++ PL DE ++GG+ L I R +AG+Y C +N V
Sbjct: 1487 YLYCDT-NAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEV 1545
Query: 247 GERESEVAELTVLERPSFVKRPSNLA--VTVDDSA--EFKCEARGDPVPTVRWRKDDGEL 302
GE EL VL P + L VTV+ S+ +C A G+PVPT+ W ++
Sbjct: 1546 GEDWLHY-ELLVLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPF 1604
Query: 303 -PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360
P R ++ +D L++ D SY CVAEN G AE TL VQ PP +Q
Sbjct: 1605 SPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQ 1664
Query: 361 VVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 419
V A L +V+ C+ +P P + W ++ SQ L + F + T L + +
Sbjct: 1665 VTAILNSSVSLPCDVHAHPNPEVTWYKD-SQALSLGEEV------FLLPGTHTLQLGRAR 1717
Query: 420 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ----TVAVDGTFVLS 475
SD G Y C+ LN AG L V PP RQ P V V VLS
Sbjct: 1718 LSDSGMYTCEALNAAGRDQKLVQLSVL------VPPAFRQAPRGPQDAVLVRVGDKAVLS 1771
Query: 476 CVATGSPVPTILWRKDG-VLVSTQDSRIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGE 533
C P PT+ W KDG LV Q R + L G L+I+ A++ D G Y+C S +GE
Sbjct: 1772 CETDALPEPTVTWYKDGQPLVLAQ--RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGE 1829
Query: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLS 580
A V+ F + VQ P PT N P V+ V+ + + L+
Sbjct: 1830 A-------VRTFTLTVQVP-PTFEN-----PKTETVSQVAGSPLVLT 1863
Score = 181 bits (460), Expect = 4e-45
Identities = 145/478 (30%), Positives = 202/478 (42%), Gaps = 34/478 (7%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I P + V + TL C A G P P + W+KG + V S + S
Sbjct: 603 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 655
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
LRI + S D G Y CVA N G + L V + V V P
Sbjct: 656 GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 712
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 243
+ C G P PT+ W KDG+P+ ++ G L + R SD+G+Y CV
Sbjct: 713 VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 771
Query: 244 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 302
+ VGE +V L V PS + N++V ++S +C++ P P + W KD L
Sbjct: 772 SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 830
Query: 303 PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 361
P+ + D L ++ + D G YTC A N G +E L V P F ++ +
Sbjct: 831 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 890
Query: 362 -VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQ 419
V G CE G P P I WR++G P + + VS G L + Q
Sbjct: 891 TVREGHPTRLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 944
Query: 420 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVLSC 476
+ G Y C+ NV G+ LEV PP I R+ P +V DG L C
Sbjct: 945 LAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATLEC 998
Query: 477 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 534
ATG P PT+ W +DG V + Q + L + A+ TGRY+C+A +G A
Sbjct: 999 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1056
Score = 177 bits (449), Expect = 8e-44
Identities = 158/512 (30%), Positives = 225/512 (43%), Gaps = 58/512 (11%)
Query: 74 PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 132
P D ++V G+ A L+C+ + P PT+ WYK G+ + L G L I
Sbjct: 1756 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVL-----AQRTQALRGGQR--LEI 1808
Query: 133 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 192
+ S D+G+Y C N GEAV +L V + V G P V+ C
Sbjct: 1809 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1865
Query: 193 PPRGHPEPTISWKKDGSPLDDKD-ERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
G P PT++W KD P++ + RGG+L ++ + + AG Y CV N E
Sbjct: 1866 -VSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 1924
Query: 252 EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 302
+ + VL P R S +A V CEA G P P V W KD L
Sbjct: 1925 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 1981
Query: 303 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 362
P R+ + D +L ++ + A D G+YTCVA N G+ T+ V PP + + D
Sbjct: 1982 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP-TIKQGADGSG 2039
Query: 363 AL----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITN 417
L G VT C G+P + W ++G P S R + +G L I+
Sbjct: 2040 TLVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISK 2091
Query: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV- 473
VQ +D G + C + AG L+V + PPV+ PV N V V G+ V
Sbjct: 2092 VQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVE 2143
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSG 532
L C A G P+P + W KDG + +Q LE G LQ+ GD+G Y+C+A + +G
Sbjct: 2144 LPCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAG 2198
Query: 533 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 564
EA + V E +PT+ +L P AP
Sbjct: 2199 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2230
Score = 177 bits (448), Expect = 1e-43
Identities = 146/489 (29%), Positives = 212/489 (43%), Gaps = 44/489 (8%)
Query: 63 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 122
Q PP I+ ++ V E L C++ P P + W+K G +E PR L
Sbjct: 784 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 838
Query: 123 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 182
+L + R D G Y C A N G + H +L V + + + V
Sbjct: 839 ADKALLQV----DRADVWDAGHYTCEALNQAGHSEKH-YNLNVWVAPVFPLRESHTLTVR 893
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 239
G P + C+ RG P P ISW+KDG PL + + ++ G L + + + G Y
Sbjct: 894 EGHPTRLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 952
Query: 240 CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
C +N+VG S+ +L V P + P+ ++V D A +C A G P PTV W
Sbjct: 953 CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 1011
Query: 297 KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 353
+ DG+ + ++ +L + + A G Y+CVAEN+ G+AE L+V PP
Sbjct: 1012 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1070
Query: 354 V--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
+ + P + AL +T CEA G P PAI W F + P S +
Sbjct: 1071 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTYLLA 1121
Query: 411 GD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468
G L +T Q D G Y C N AG +EV PP I + + + V
Sbjct: 1122 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKV 1175
Query: 469 -DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 526
DG T L C TG P P + W KDG ++ D+ + +LQ+ A L G Y+CI
Sbjct: 1176 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1235
Query: 527 ASTPSGEAT 535
A+ GE T
Sbjct: 1236 AANAVGEKT 1244
Score = 176 bits (447), Expect = 1e-43
Identities = 132/481 (27%), Positives = 201/481 (41%), Gaps = 30/481 (6%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I PS+L ++ PA L C+A G P P + W+K G++++ + LLPS +
Sbjct: 2481 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNA 2538
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
L D + CV N +GEA H + + +D V + P
Sbjct: 2539 LLLTA-----PGPQDSAQFECVVSNEVGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAP 2591
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNM 245
V+ C G P PT+SW K G+ L + + G L I AG+Y C N
Sbjct: 2592 VVLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS 2650
Query: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
G V LTV P PS + ++ CEA G P PT+ W+K+ +
Sbjct: 2651 AGVAHKHVF-LTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATG 2709
Query: 306 -RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 364
++ L+I + D G+Y C+A+N G A L VQ PP D
Sbjct: 2710 VSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTE 2769
Query: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDV 423
G C+A G+P+P I W ++G QP + +F++ +G+L + N++ D
Sbjct: 2770 GSHAFLPCKARGSPEPNITWDKDG--------QPVSGAEGKFTIQPSGELLVKNLEGQDA 2821
Query: 424 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV 483
G Y C N G + +L + + PV P ++++ + L C A GSP
Sbjct: 2822 GTYTCTAENAVGRARRRVHLTILVL------PVFTTLPGDRSLRLGDRLWLRCAARGSPT 2875
Query: 484 PTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
P I W + V+ S +Q LQ D+G Y C A G +++ V+
Sbjct: 2876 PRIGWTVNDRPVTEGVS--EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 2933
Query: 544 E 544
E
Sbjct: 2934 E 2934
Score = 173 bits (439), Expect = 1e-42
Identities = 127/385 (32%), Positives = 176/385 (45%), Gaps = 32/385 (8%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I DL ++G A L CKA G P P I W K G+ V + PSG
Sbjct: 2755 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 2810
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
L ++ + G+ D G Y C A N +G A L + +L F P D + +G+
Sbjct: 2811 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 2863
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 246
+ C RG P P I W + P+ + G L + D+G YVC N V
Sbjct: 2864 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQD-GGSTLQRAAVSREDSGTYVCWAENRV 2921
Query: 247 GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 302
G ++ V E VL+ +F S L V S + C RGDPVP + W KD L
Sbjct: 2922 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 2977
Query: 303 PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360
S R+++++ +L IR+ D G Y C+AEN +G A+ L +Q P F V+P+D
Sbjct: 2978 RGSHLRHQLQNG-SLTIRRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 3036
Query: 361 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420
V G V +C+ATG P P I W + G QP ++S R G L + NV+
Sbjct: 3037 TVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVET 3088
Query: 421 SDVGYYICQTLNVAGSIITKAYLEV 445
D G Y C N+ GS +A+L V
Sbjct: 3089 GDAGTYDCVAHNLLGSATARAFLVV 3113
Score = 173 bits (438), Expect = 1e-42
Identities = 156/572 (27%), Positives = 238/572 (41%), Gaps = 72/572 (12%)
Query: 52 NSLGYTGSRLRQE-DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 107
N +G + L+ E PP+I E P+ + V + ATL C A G+P PT+ W + G+
Sbjct: 957 NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP 1016
Query: 108 VETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 167
V + L G + R G Y CVA N G A E+++
Sbjct: 1017 VGAELG-----LQLQNQGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSV 1064
Query: 168 LRDDFRQNPSD----VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG 223
L D + A+ P + C+ G P P I W + P+ ++ + GG
Sbjct: 1065 LVPPELIGDLDPLTNITAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGG 1123
Query: 224 -KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAE 280
L +T T++ D+G Y C+ +N GE + + VL PS + V D +A
Sbjct: 1124 WMLKMTQTQEQDSGLYSCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAH 1182
Query: 281 FKCEARGDPVPTVRWRKDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 338
C G P P + W KD L + + + D L++ + G Y+C+A N VG+
Sbjct: 1183 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGE 1242
Query: 339 AEASATLTVQEPPHFVVKPRDQV-----VALGRTVTFQCEATGNPQPAIFWRREGSQNLL 393
L+V P + D V + ++ CEA P P I W ++G+
Sbjct: 1243 KTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA---- 1298
Query: 394 FSYQPPQSSSRFSVSQ-TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 452
P ++S + T L I N Q+ D G Y C N G + ++EV
Sbjct: 1299 ----PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI----- 1349
Query: 453 PPPVIRQGPVNQT------VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 506
PP + + P+ + V+ T L C + P PTI W KDG V T SR++ L
Sbjct: 1350 PPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLG 1408
Query: 507 NG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 565
G +LQI+ ++ D+GRY C+A+ +GE + Q+F V +Q P P
Sbjct: 1409 EGRLLQIQPTQVSDSGRYLCVATNVAGE-------DDQDFNVLIQVP-----------PM 1450
Query: 566 KPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597
+V D S LS + G T I+E
Sbjct: 1451 FQKVGDFSAAFEILSREEEARGGVTEYREIVE 1482
Score = 162 bits (410), Expect = 3e-39
Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 69/519 (13%)
Query: 67 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I + ++ G+ A L C G P P + W+K G + +H + P
Sbjct: 1161 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 1215
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 181
G L L+++ S G Y C+A N +GE H + L IL +V V
Sbjct: 1216 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 1271
Query: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 240
V P + C+ P P I+W KDG+P + + G L I +K DAG+Y C
Sbjct: 1272 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1330
Query: 241 VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 293
V TN +GE + VL PS K + V+ + +CE+ P PT+
Sbjct: 1331 VVTNELGEAVKNY-HVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTI 1389
Query: 294 RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
RW KD + P SR ++ + L+I+ D G Y CVA N+ G+ + + +Q PP
Sbjct: 1390 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1449
Query: 352 HFV----------VKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 391
F + R++ G T C+ P P + W RE
Sbjct: 1450 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 1506
Query: 392 LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450
QP + SV Q G L I V+ + G Y C+ N G L V
Sbjct: 1507 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 1558
Query: 451 DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 505
PPVI G + TV T L C A G+PVPTI W ++G L + R++ L
Sbjct: 1559 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 1613
Query: 506 ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
E+G VLQ+ A++ D Y C+A +G A + VQ
Sbjct: 1614 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1652
Score = 162 bits (409), Expect = 3e-39
Identities = 129/472 (27%), Positives = 192/472 (40%), Gaps = 45/472 (9%)
Query: 79 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 135
+ + PA L C P P + WY+ +D P S +L G + + +V
Sbjct: 1480 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 1531
Query: 136 RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 193
+ G Y C A N +GE H L + ++ D + +V V ++C P
Sbjct: 1532 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 1586
Query: 194 PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 252
G+P PTISW ++G P + G+ L ++ +DA Y+CV N G E +
Sbjct: 1587 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 1645
Query: 253 VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 309
+ L V P + ++ S C+ P P V W KD L + +
Sbjct: 1646 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 1705
Query: 310 RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALG 365
HTL++ + D G YTC A N G+ + L+V PP F PR +V +G
Sbjct: 1706 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1765
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVG 424
CE P+P + W ++G QP + R + G L I Q SD G
Sbjct: 1766 DKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKG 1817
Query: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVATGSP 482
Y C+ NVAG + L V + PP + P +TV+ VL+C +G P
Sbjct: 1818 LYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVP 1870
Query: 483 VPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 534
PT+ W KD + V + G LQ+ + G YTC+A EA
Sbjct: 1871 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 1922
Score = 160 bits (405), Expect = 1e-38
Identities = 144/505 (28%), Positives = 204/505 (40%), Gaps = 48/505 (9%)
Query: 67 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV-----------ETDKD 113
PP I E VS G+ TL C A G P P I W K + V +
Sbjct: 16 PPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWG 75
Query: 114 DPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFR 173
HR+L SL F RI G D G+Y C A N G A L +
Sbjct: 76 QVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA 130
Query: 174 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR--GGKLMITYTR 231
+V+ G ++C G P P + W KD P+ + ++ G L IT +
Sbjct: 131 GAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSH 189
Query: 232 KSDAGKYVCVGTNMVGERESEVAELTVLERPSF--VKRPSNLAVTVDDSAEFKCEARGDP 289
D G+Y CV + G++ + +L V P+ +AV D + CEARG P
Sbjct: 190 VGDEGRYQCVAFSPAGQQARDF-QLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVP 248
Query: 290 VPTVRWRKDDGELPKSRYEI--RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
P + W KD LP S + R L++ + + D G YTC A N VG AE + L V
Sbjct: 249 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDV 308
Query: 348 QEPPHFVV---KPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 404
PP +P GR V +C A G+P P + W EG P S+
Sbjct: 309 YVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL--------PVAESNE 360
Query: 405 FSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP--VIRQGP 461
+ G L + + + G Y C + AG + + +EV + PP ++ +G
Sbjct: 361 SRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV------QVPPQLLVAEGL 414
Query: 462 VNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 521
T V L C A+GSPVPTI W ++G + L I + +L +G
Sbjct: 415 GQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSG 474
Query: 522 RYTCIASTPSGEATWSAYIEVQEFG 546
+ C A+ +G A A +EV G
Sbjct: 475 LFACQATNEAGTA--GAEVEVSVHG 497
Score = 155 bits (393), Expect = 2e-37
Identities = 148/534 (27%), Positives = 216/534 (40%), Gaps = 43/534 (8%)
Query: 67 PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I ++ V + L C+A G PTP I W+K G + P S +++
Sbjct: 218 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 271
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAV 183
G ++ GR D GVY C A N +G A + + V + P V
Sbjct: 272 GGR---QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 328
Query: 184 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 242
G P +EC RGHP PT+SW +G P+ + +E R+ G L + ++ +G Y CV
Sbjct: 329 GRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 387
Query: 243 TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-- 299
++ GE + + E+ V + + + V E C+A G PVPT++W ++
Sbjct: 388 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 447
Query: 300 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QEPPHFVVKP 357
E TL I V G + C A N G A A ++V + P + P
Sbjct: 448 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 507
Query: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQTG 411
Q G A +P W L+ + P S + S
Sbjct: 508 IGQY-HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP 566
Query: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471
L I V D G Y C N+AG + L+V PP I GPVN+ V + +
Sbjct: 567 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENAS 620
Query: 472 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 531
L C+A+G P P + W K VS+ ++ VL+I A+L D G Y C+AS +
Sbjct: 621 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 680
Query: 532 GEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 584
G +G+ V PPR T P PS P V R T + P+
Sbjct: 681 GSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 724
Score = 153 bits (387), Expect = 1e-36
Identities = 148/519 (28%), Positives = 212/519 (40%), Gaps = 71/519 (13%)
Query: 71 VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
V+ P L+V++G +P L C+A G P PTI+W + G E + +
Sbjct: 402 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQV 456
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181
G+ + V S G++ C A N G A A +EV++ + P + V
Sbjct: 457 ASQGTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 506
Query: 182 AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 223
+G+ PA C PP RG HP+P + W GS L + I +
Sbjct: 507 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 563
Query: 224 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 280
L I D G Y C TN+ GE + EVA L VL P+ P N AV + S
Sbjct: 564 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 622
Query: 281 FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 336
+C A G P P V W K G P S + D L+I + D GSY CVA N+
Sbjct: 623 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 680
Query: 337 GKAEASATLTVQEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 395
G E L V PP + P V + V C ATG P P + W ++G+
Sbjct: 681 GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP----- 735
Query: 396 YQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454
P + V G LT+ + + SD G Y C ++ G L+V P
Sbjct: 736 -VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMP 788
Query: 455 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 514
P I +N +V + + L C + P P + W KDG + + + +LQ+
Sbjct: 789 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 848
Query: 515 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 553
A + D G YTC A +G + + + + PV P R
Sbjct: 849 ADVWDAGHYTCEALNQAGHS--EKHYNLNVWVAPVFPLR 885
Score = 142 bits (358), Expect = 3e-33
Identities = 121/456 (26%), Positives = 190/456 (41%), Gaps = 35/456 (7%)
Query: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 200
DEG+Y C A N GE+ +L+V ++ + P + V +EC G P P
Sbjct: 577 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 633
Query: 201 TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 259
+SW K P+ +++ G L I + SDAG Y CV +N+ G E L V
Sbjct: 634 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 692
Query: 260 ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 314
P PS V V+ C A G P PT+ W KD + +
Sbjct: 693 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 752
Query: 315 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 374
L + A D G Y+CVA + VG+ L V PP + + + V +V +C++
Sbjct: 753 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQS 812
Query: 375 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYICQTL 431
P P + W ++G R V + D + V R+DV G+Y C+ L
Sbjct: 813 HAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 862
Query: 432 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 491
N AG ++ + + +A P +R+ TV LSC G P P I WRKD
Sbjct: 863 NQAGH--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTRLSCECRGVPFPKISWRKD 917
Query: 492 GVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ---EFG 546
G + + + ++ + +L + A+L G YTC S G ++ +EV +
Sbjct: 918 GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 977
Query: 547 VPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 582
P +P PT +++ + E + T++W+
Sbjct: 978 GPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 1011
Score = 133 bits (334), Expect = 2e-30
Identities = 103/319 (32%), Positives = 143/319 (44%), Gaps = 23/319 (7%)
Query: 37 GNDHGTPIPTSDNDDNSLGYTGSRLRQEDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRP 95
G D GT T++N ++G R+ P P D + G+ L C A G P
Sbjct: 2818 GQDAGTYTCTAEN---AVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSP 2874
Query: 96 TPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG- 154
TP I W T D P + + G R SR D G YVC A N +G
Sbjct: 2875 TPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA---VSREDSGTYVCWAENRVGR 2923
Query: 155 -EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD 213
+AVS E +L+ + S ++ VG ++C RG P P I W KDG PL
Sbjct: 2924 TQAVSFVHVKEAPVLQGEAF---SYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLPLRG 2979
Query: 214 KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAV 273
R ++ G L I T + DAG+Y C+ N +G + +V L + P F P ++ V
Sbjct: 2980 SHLRHQLQNGSLTIRRTERDDAGRYQCLAENEMGVAK-KVVILVLQSAPVFQVEPQDMTV 3038
Query: 274 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVA 332
D +C+A G+P PT+ W + L SR D +L + V GD G+Y CVA
Sbjct: 3039 RSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 3098
Query: 333 ENMVGKAEASATLTVQEPP 351
N++G A A A L V+ P
Sbjct: 3099 HNLLGSATARAFLVVRGEP 3117
Score = 125 bits (313), Expect = 4e-28
Identities = 120/414 (28%), Positives = 172/414 (41%), Gaps = 41/414 (9%)
Query: 155 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKD----GSP 210
E + + S+ +R+D R+ ++V G+ +EC G P P I W KD G P
Sbjct: 6 EPLLNTGSVVPPSIREDGRK--ANVSGMAGQSLTLECDA-NGFPVPEIVWLKDAQLVGVP 62
Query: 211 L------------DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 258
L R+ G L ++ D+G Y C N G + + L V
Sbjct: 63 LGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDF-HLLV 121
Query: 259 LERPSFVKRPSNLAVT--VDDSAEFKCEARGDPVPTVRWRKD-DGELPKSRY-EIRDD-H 313
L PS + + V E +C G P P V W KD LP + ++++D
Sbjct: 122 LTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ 181
Query: 314 TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL--GRTVTFQ 371
L+I GD G Y CVA + G+ L V PP VA+ V
Sbjct: 182 VLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLL 241
Query: 372 CEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTL 431
CEA G P P I W ++G+ LL P S+ L + Q SD G Y C+
Sbjct: 242 CEARGVPTPNITWFKDGA--LL-----PTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKAS 294
Query: 432 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV-AVDGTFV-LSCVATGSPVPTILWR 489
N G+ L+V PP + G V AV G V L CVA G P PT+ W
Sbjct: 295 NAVGAAEKATRLDVYV-----PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWH 349
Query: 490 KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
+G+ V+ + + + VL++ +G Y+C+AS+P+GEA +EVQ
Sbjct: 350 HEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ 403
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 208 bits (529), Expect = 4e-53
Identities = 149/478 (31%), Positives = 215/478 (44%), Gaps = 31/478 (6%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
P + PS + E L C+A G P PTI W K G V T +LP G L
Sbjct: 2757 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 2811
Query: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 187
RI H S D G Y+C+A+N G A+ V + D+ G A
Sbjct: 2812 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 2864
Query: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 246
+ C+ RG PEP I+W KDG P+ + + TI+ G+L++ DAG Y C N V
Sbjct: 2865 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2923
Query: 247 GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 306
G V LT+L P F P + ++ + D +C ARG P P + W +D + +
Sbjct: 2924 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 2982
Query: 307 YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA-LG 365
E TL+ V+ D G+Y C AEN VG+ +A + + V+E P + +V +G
Sbjct: 2983 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 3042
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 425
++ C G+P P I W ++G P + S Q G LTI +R D G
Sbjct: 3043 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIHRTERDDAGR 3094
Query: 426 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 485
Y C N G + K + ++ + PV + P + TV L C ATG P PT
Sbjct: 3095 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 3148
Query: 486 ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
I W + G + R++ L +G L + + GD G Y C+A G AT A++ V+
Sbjct: 3149 IEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 3205
Score = 196 bits (498), Expect = 2e-49
Identities = 162/531 (30%), Positives = 232/531 (43%), Gaps = 47/531 (8%)
Query: 44 IPTSDNDD------NSLGYTGSRLRQEDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPT 96
+ T+D+ D N+ G T R E P I P + VS + A L C+A+G P
Sbjct: 2451 LSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA 2510
Query: 97 PTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEA 156
P + W K +RV D PR +LP GSL ++ D G Y+C+A N G
Sbjct: 2511 PLVSWRK--DRVPLDPRSPRFE--ILPEGSLRIQPVL-----AQDAGHYLCLASNSAG-- 2559
Query: 157 VSHNASLEVAILRDD-FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD 215
S ++ +L +PS++ + PA++ C+ G P+P + W KDG LD +
Sbjct: 2560 -SDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKLDFRL 2617
Query: 216 ERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLA 272
++ R L++T D+ ++ CV +N VGE + ++TV P+ ++
Sbjct: 2618 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH-RLYQVTVHVPPTIADDQTDFT 2676
Query: 273 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTC 330
VT+ C + G P PTV W K +L S Y + L+I + G YTC
Sbjct: 2677 VTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTC 2736
Query: 331 VAENMVGKAEASATLTVQEPPHFVVKPRDQVV--ALGRTVTFQCEATGNPQPAIFWRREG 388
A N G A LTVQ P VVKP VV V CEA+G P+P I W++EG
Sbjct: 2737 SARNSAGVAHKHVFLTVQASP--VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 2794
Query: 389 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 448
+ V G L I + D G Y+C N AGS + K L V
Sbjct: 2795 LN--------VATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV--- 2843
Query: 449 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG 508
+ PPVI G + + L C A GSP P I W KDG VS + + +G
Sbjct: 2844 ---QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG 2900
Query: 509 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL 559
L ++ + D G YTC A G A ++ + +PV P D +L
Sbjct: 2901 ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI--LVLPVFTTLPGDRSL 2949
Score = 192 bits (489), Expect = 2e-48
Identities = 158/510 (30%), Positives = 222/510 (43%), Gaps = 49/510 (9%)
Query: 67 PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 123
PP I + L+ GE T+ C G P + W K G + P S R LL
Sbjct: 2119 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 2171
Query: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 180
GS LRI + D G++ CVA + G A N +L+V + L QN DV+
Sbjct: 2172 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 2226
Query: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 240
V G + C+ RG P P +SW KDG PL + +G L + D+G Y C
Sbjct: 2227 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 2282
Query: 241 VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 298
V + GE +LTV+E P +P+ L++T E C+A+G P P + W KD
Sbjct: 2283 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 2341
Query: 299 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
L + R L++R D G YTC+AE+ G E S + VQ PP+ +V PR
Sbjct: 2342 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 2395
Query: 359 DQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 415
+G + +C P P I W R+G ++ RF L +
Sbjct: 2396 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQL 2448
Query: 416 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 475
+ +D G Y C N AGS +E+ V P IR GP V+V+ T +L
Sbjct: 2449 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLP 2502
Query: 476 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 535
C A G P P + WRKD V + + R + L G L+I+ D G Y C+AS +G
Sbjct: 2503 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 2562
Query: 536 WSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 565
+ V E P P P++ L P+
Sbjct: 2563 QGRDLRVLE--PPAIAPSPSNLTLTAHTPA 2590
Score = 186 bits (472), Expect = 2e-46
Identities = 156/542 (28%), Positives = 231/542 (42%), Gaps = 56/542 (10%)
Query: 67 PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I + P++L ++ G P L C A+G P P I W+K G+ + +++ R+ R+L
Sbjct: 2302 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 2361
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
D G+Y C+A + G S V + P VG
Sbjct: 2362 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 2402
Query: 185 ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 240
V+EC P P I+W +DG L +D + RG L + +D+G Y C
Sbjct: 2403 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 2461
Query: 241 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300
N G S + + P+ P + V+V+ +A C+A G P P V WRKD
Sbjct: 2462 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 2520
Query: 301 EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
L P+S R+EI + +L+I+ V A D G Y C+A N G L V EPP P
Sbjct: 2521 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2580
Query: 359 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 418
+ + CEA+G+P+P + W ++G Q L F Q + + + L +T
Sbjct: 2581 NLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAP 2635
Query: 419 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 478
D + C N G + Y V PP I + TV + VL+C +
Sbjct: 2636 GPQDSAQFECVVSNEVGE-AHRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLTCHS 2689
Query: 479 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 538
TG P PT+ W K G + + S + +G L+I A GRYTC A +G A
Sbjct: 2690 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHV 2749
Query: 539 YIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 591
++ VQ PV P P+ + L+P E + + R T+T WQ + AT
Sbjct: 2750 FLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNVATG 2800
Query: 592 TS 593
S
Sbjct: 2801 VS 2802
Score = 184 bits (467), Expect = 6e-46
Identities = 175/569 (30%), Positives = 246/569 (43%), Gaps = 86/569 (15%)
Query: 44 IPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 103
IP S + D+ LG G + ++ TL C++ P PTI WYK
Sbjct: 1440 IPPSISKDDPLGEVGVK---------------EVKTKVNSTLTLECESWAVPPPTIRWYK 1484
Query: 104 GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE-------- 155
G+ V P S +L G L L+I + S D G Y+CVA N GE
Sbjct: 1485 DGQPVT-----PSSRLQVLGEGRL--LQIQPTQVS--DSGRYLCVATNVAGEDDQDFNVL 1535
Query: 156 ---------AVSHNASLEVAILRDDFRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWK 205
+A+ E+ ++ R ++ V PA + C P P ++W
Sbjct: 1536 IQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDT-NAIPPPDLTWY 1594
Query: 206 KDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF 264
++ PL DE ++GG+ L I R +AG+Y C +N VGE EL VL P
Sbjct: 1595 REDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY-ELLVLTPPVI 1653
Query: 265 VKRPSNLA--VTVDDSA--EFKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDD-HTLKIR 318
+ L VTV+ S+ +C A G+PVPT+ W ++ P R ++ +D L++
Sbjct: 1654 LGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVS 1713
Query: 319 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA-LGRTVTFQCEATGN 377
D SY CVAEN G AE TL VQ PP +QV A L +V+ C+ +
Sbjct: 1714 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAH 1773
Query: 378 PQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSI 437
P P + W ++ SQ L + F + T L + + SD G Y C+ LN AG
Sbjct: 1774 PNPEVTWYKD-SQALSLGEEV------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRD 1826
Query: 438 ITKAYLEVTDVIADRPPPVIRQGPVNQ----TVAVDGTFVLSCVATGSPVPTILWRKDG- 492
L V PP RQ P V V VLSC P PT+ W KDG
Sbjct: 1827 QKLVQLSVL------VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQ 1880
Query: 493 VLVSTQDSRIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 551
LV Q R + L G L+I+ A++ D G Y+C S +GEA V+ F + VQ
Sbjct: 1881 PLVLAQ--RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA-------VRTFTLTVQV 1931
Query: 552 PRPTDPNLIPSAPSKPEVTDVSRNTVTLS 580
P PT N P V+ V+ + + L+
Sbjct: 1932 P-PTFEN-----PKTETVSQVAGSPLVLT 1954
Score = 183 bits (465), Expect = 1e-45
Identities = 145/478 (30%), Positives = 204/478 (42%), Gaps = 34/478 (7%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I P + V + TL C A G P P + W+KG + V S + S
Sbjct: 694 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 746
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
LRI + S D G Y CVA N G + L V + V V P
Sbjct: 747 GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 803
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 243
+ C G P PT+ W KDG+P+ ++ G L + R SD+G+Y CV
Sbjct: 804 VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 862
Query: 244 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 302
+ VGE +V L V PS + N++V ++S +C++ P P + W KD L
Sbjct: 863 SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 921
Query: 303 PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 361
P+ + D L ++ + D G YTC A N G++E L V P F ++ +
Sbjct: 922 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTL 981
Query: 362 -VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQ 419
V G + CE G P P I WR++G P + + VS G L + Q
Sbjct: 982 TVREGHPTSLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 1035
Query: 420 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVLSC 476
+ G Y C+ NV G+ LEV PP I R+ P +V DG L C
Sbjct: 1036 LAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATLEC 1089
Query: 477 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 534
ATG P PT+ W +DG V + Q + L + A+ TGRY+C+A +G A
Sbjct: 1090 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 1147
Score = 177 bits (449), Expect = 8e-44
Identities = 146/489 (29%), Positives = 212/489 (43%), Gaps = 44/489 (8%)
Query: 63 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 122
Q PP I+ ++ V E L C++ P P + W+K G +E PR L
Sbjct: 875 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 929
Query: 123 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 182
+L + R D G Y C A N G + H +L V + + + V
Sbjct: 930 ADKALLQV----DRADVWDAGHYTCEALNQAGRSEKH-YNLNVWVAPVFPLRESHTLTVR 984
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 239
G P + C+ RG P P ISW+KDG PL + + ++ G L + + + G Y
Sbjct: 985 EGHPTSLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 1043
Query: 240 CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
C +N+VG S+ +L V P + P+ ++V D A +C A G P PTV W
Sbjct: 1044 CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 1102
Query: 297 KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 353
+ DG+ + ++ +L + + A G Y+CVAEN+ G+AE L+V PP
Sbjct: 1103 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 1161
Query: 354 V--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
+ + P + AL +T CEA G P PAI W F + P S +
Sbjct: 1162 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTYLLA 1212
Query: 411 GD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468
G L +T Q D G Y C N AG +EV PP I + + + V
Sbjct: 1213 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKV 1266
Query: 469 -DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 526
DG T L C TG P P + W KDG ++ D+ + +LQ+ A L G Y+CI
Sbjct: 1267 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1326
Query: 527 ASTPSGEAT 535
A+ GE T
Sbjct: 1327 AANAVGEKT 1335
Score = 177 bits (449), Expect = 8e-44
Identities = 158/512 (30%), Positives = 226/512 (44%), Gaps = 58/512 (11%)
Query: 74 PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 132
P D ++V G+ A L+C+ + P PT+ WYK G+ + + L G L I
Sbjct: 1847 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-----RTQALRGGQR--LEI 1899
Query: 133 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 192
+ S D+G+Y C N GEAV +L V + V G P V+ C
Sbjct: 1900 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 1956
Query: 193 PPRGHPEPTISWKKDGSPLDDKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
G P PT++W KD P++ + RGG+L ++ + + AG Y CV N E
Sbjct: 1957 VS-GVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 2015
Query: 252 EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 302
+ + VL P R S +A V CEA G P P V W KD L
Sbjct: 2016 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 2072
Query: 303 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 362
P R+ + D +L ++ + A D G+YTCVA N G+ T+ V PP + + D
Sbjct: 2073 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP-TIKQGADGSG 2130
Query: 363 AL----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITN 417
L G VT C G+P + W ++G P S R + +G L I+
Sbjct: 2131 TLVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISK 2182
Query: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV- 473
VQ +D G + C + AG L+V + PPV+ PV N V V G+ V
Sbjct: 2183 VQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVE 2234
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSG 532
L C A G P+P + W KDG + +Q LE G LQ+ GD+G Y+C+A + +G
Sbjct: 2235 LPCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAG 2289
Query: 533 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 564
EA + V E +PT+ +L P AP
Sbjct: 2290 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2321
Score = 176 bits (447), Expect = 1e-43
Identities = 132/481 (27%), Positives = 201/481 (41%), Gaps = 30/481 (6%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I PS+L ++ PA L C+A G P P + W+K G++++ + LLPS +
Sbjct: 2572 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNA 2629
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
L D + CV N +GEA H + + +D V + P
Sbjct: 2630 LLLTA-----PGPQDSAQFECVVSNEVGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAP 2682
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNM 245
V+ C G P PT+SW K G+ L + + G L I AG+Y C N
Sbjct: 2683 VVLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS 2741
Query: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
G V LTV P PS + ++ CEA G P PT+ W+K+ +
Sbjct: 2742 AGVAHKHVF-LTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATG 2800
Query: 306 -RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 364
++ L+I + D G+Y C+A+N G A L VQ PP D
Sbjct: 2801 VSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTE 2860
Query: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDV 423
G C+A G+P+P I W ++G QP + +F++ +G+L + N++ D
Sbjct: 2861 GSHAFLPCKARGSPEPNITWDKDG--------QPVSGAEGKFTIQPSGELLVKNLEGQDA 2912
Query: 424 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV 483
G Y C N G + +L + + PV P ++++ + L C A GSP
Sbjct: 2913 GTYTCTAENAVGRARRRVHLTILVL------PVFTTLPGDRSLRLGDRLWLRCAARGSPT 2966
Query: 484 PTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
P I W + V+ S +Q LQ D+G Y C A G +++ V+
Sbjct: 2967 PRIGWTVNDRPVTEGVS--EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 3024
Query: 544 E 544
E
Sbjct: 3025 E 3025
Score = 174 bits (440), Expect = 8e-43
Identities = 156/572 (27%), Positives = 238/572 (41%), Gaps = 72/572 (12%)
Query: 52 NSLGYTGSRLRQE-DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 107
N +G + L+ E PP+I E P+ + V + ATL C A G+P PT+ W + G+
Sbjct: 1048 NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP 1107
Query: 108 VETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 167
V + L G + R G Y CVA N G A E+++
Sbjct: 1108 VGAELG-----LQLQNQGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSV 1155
Query: 168 LRDDFRQNPSD----VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG 223
L D + A+ P + C+ G P P I W + P+ ++ + GG
Sbjct: 1156 LVPPELIGDLDPLTNITAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGG 1214
Query: 224 -KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAE 280
L +T T++ D+G Y C+ +N GE + + VL PS + V D +A
Sbjct: 1215 WMLKMTQTQEQDSGLYSCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAH 1273
Query: 281 FKCEARGDPVPTVRWRKDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 338
C G P P + W KD L + + + D L++ + G Y+C+A N VG+
Sbjct: 1274 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGE 1333
Query: 339 AEASATLTVQEPPHFVVKPRDQV-----VALGRTVTFQCEATGNPQPAIFWRREGSQNLL 393
L+V P + D V + ++ CEA P P I W ++G+
Sbjct: 1334 KTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA---- 1389
Query: 394 FSYQPPQSSSRFSVSQ-TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 452
P ++S + T L I N Q+ D G Y C N G + ++EV
Sbjct: 1390 ----PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI----- 1440
Query: 453 PPPVIRQGPVNQT------VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 506
PP + + P+ + V+ T L C + P PTI W KDG V T SR++ L
Sbjct: 1441 PPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLG 1499
Query: 507 NG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 565
G +LQI+ ++ D+GRY C+A+ +GE + Q+F V +Q P P
Sbjct: 1500 EGRLLQIQPTQVSDSGRYLCVATNVAGE-------DDQDFNVLIQVP-----------PM 1541
Query: 566 KPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597
+V D S LS + G T I+E
Sbjct: 1542 FQKVGDFSAAFEILSREEEARGGVTEYREIVE 1573
Score = 171 bits (434), Expect = 4e-42
Identities = 126/385 (32%), Positives = 175/385 (45%), Gaps = 32/385 (8%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I DL ++G A L CKA G P P I W K G+ V + PSG
Sbjct: 2846 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 2901
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
L ++ + G+ D G Y C A N +G A L + +L F P D + +G+
Sbjct: 2902 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 2954
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 246
+ C RG P P I W + P+ + G L + D+G YVC N V
Sbjct: 2955 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQD-GGSTLQRAAVSREDSGTYVCWAENRV 3012
Query: 247 GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 302
G ++ V E VL+ +F S L V S + C RGDPVP + W KD L
Sbjct: 3013 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 3068
Query: 303 PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360
S R+++++ +L I + D G Y C+AEN +G A+ L +Q P F V+P+D
Sbjct: 3069 RGSHLRHQLQNG-SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 3127
Query: 361 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420
V G V +C+ATG P P I W + G QP ++S R G L + NV+
Sbjct: 3128 TVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVET 3179
Query: 421 SDVGYYICQTLNVAGSIITKAYLEV 445
D G Y C N+ GS +A+L V
Sbjct: 3180 GDAGTYDCVAHNLLGSATARAFLVV 3204
Score = 162 bits (410), Expect = 3e-39
Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 69/519 (13%)
Query: 67 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I + ++ G+ A L C G P P + W+K G + +H + P
Sbjct: 1252 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 1306
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 181
G L L+++ S G Y C+A N +GE H + L IL +V V
Sbjct: 1307 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 1362
Query: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 240
V P + C+ P P I+W KDG+P + + G L I +K DAG+Y C
Sbjct: 1363 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1421
Query: 241 VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 293
V TN +GE + VL PS K + V+ + +CE+ P PT+
Sbjct: 1422 VVTNELGEAVKNY-HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTI 1480
Query: 294 RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
RW KD + P SR ++ + L+I+ D G Y CVA N+ G+ + + +Q PP
Sbjct: 1481 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 1540
Query: 352 HFV----------VKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 391
F + R++ G T C+ P P + W RE
Sbjct: 1541 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 1597
Query: 392 LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450
QP + SV Q G L I V+ + G Y C+ N G L V
Sbjct: 1598 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 1649
Query: 451 DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 505
PPVI G + TV T L C A G+PVPTI W ++G L + R++ L
Sbjct: 1650 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 1704
Query: 506 ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
E+G VLQ+ A++ D Y C+A +G A + VQ
Sbjct: 1705 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 1743
Score = 162 bits (409), Expect = 3e-39
Identities = 129/472 (27%), Positives = 192/472 (40%), Gaps = 45/472 (9%)
Query: 79 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 135
+ + PA L C P P + WY+ +D P S +L G + + +V
Sbjct: 1571 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 1622
Query: 136 RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 193
+ G Y C A N +GE H L + ++ D + +V V ++C P
Sbjct: 1623 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 1677
Query: 194 PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 252
G+P PTISW ++G P + G+ L ++ +DA Y+CV N G E +
Sbjct: 1678 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 1736
Query: 253 VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 309
+ L V P + ++ S C+ P P V W KD L + +
Sbjct: 1737 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 1796
Query: 310 RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALG 365
HTL++ + D G YTC A N G+ + L+V PP F PR +V +G
Sbjct: 1797 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 1856
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVG 424
CE P+P + W ++G QP + R + G L I Q SD G
Sbjct: 1857 DKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKG 1908
Query: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVATGSP 482
Y C+ NVAG + L V + PP + P +TV+ VL+C +G P
Sbjct: 1909 LYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVP 1961
Query: 483 VPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 534
PT+ W KD + V + G LQ+ + G YTC+A EA
Sbjct: 1962 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 2013
Score = 155 bits (393), Expect = 2e-37
Identities = 148/534 (27%), Positives = 216/534 (40%), Gaps = 43/534 (8%)
Query: 67 PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I ++ V + L C+A G PTP I W+K G + P S +++
Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 362
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAV 183
G ++ GR D GVY C A N +G A + + V + P V
Sbjct: 363 GGR---QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 419
Query: 184 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 242
G P +EC RGHP PT+SW +G P+ + +E R+ G L + ++ +G Y CV
Sbjct: 420 GRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 478
Query: 243 TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-- 299
++ GE + + E+ V + + + V E C+A G PVPT++W ++
Sbjct: 479 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 538
Query: 300 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QEPPHFVVKP 357
E TL I V G + C A N G A A ++V + P + P
Sbjct: 539 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 598
Query: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQTG 411
Q G A +P W L+ + P S + S
Sbjct: 599 IGQY-HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP 657
Query: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471
L I V D G Y C N+AG + L+V PP I GPVN+ V + +
Sbjct: 658 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENAS 711
Query: 472 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 531
L C+A+G P P + W K VS+ ++ VL+I A+L D G Y C+AS +
Sbjct: 712 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 771
Query: 532 GEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 584
G +G+ V PPR T P PS P V R T + P+
Sbjct: 772 GSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 815
Score = 153 bits (387), Expect = 1e-36
Identities = 149/519 (28%), Positives = 212/519 (40%), Gaps = 71/519 (13%)
Query: 71 VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
V+ P L+V++G +P L C+A G P PTI+W + G E + +
Sbjct: 493 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAE-----ELAGVQV 547
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181
G+ L I H G++ C A N G A A +EV++ + P + V
Sbjct: 548 ASQGTT--LHIDHVELDH--SGLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 597
Query: 182 AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 223
+G+ PA C PP RG HP+P + W GS L + I +
Sbjct: 598 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 654
Query: 224 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 280
L I D G Y C TN+ GE + EVA L VL P+ P N AV + S
Sbjct: 655 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 713
Query: 281 FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 336
+C A G P P V W K G P S + D L+I + D GSY CVA N+
Sbjct: 714 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 771
Query: 337 GKAEASATLTVQEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 395
G E L V PP + P V + V C ATG P P + W ++G+
Sbjct: 772 GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP----- 826
Query: 396 YQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454
P + V G LT+ + + SD G Y C ++ G L+V P
Sbjct: 827 -VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMP 879
Query: 455 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 514
P I +N +V + + L C + P P + W KDG + + + +LQ+
Sbjct: 880 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 939
Query: 515 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 553
A + D G YTC A +G + + + + PV P R
Sbjct: 940 ADVWDAGHYTCEALNQAGRS--EKHYNLNVWVAPVFPLR 976
Score = 148 bits (374), Expect = 4e-35
Identities = 146/540 (27%), Positives = 210/540 (38%), Gaps = 74/540 (13%)
Query: 52 NSLGYTGSRLRQEDF-PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV 108
N +G T R + + PP I E VS G+ TL C A G P P I W K + V
Sbjct: 78 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 137
Query: 109 -----------ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV 157
+ HR+L SL F RI GR R G +
Sbjct: 138 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQA---------GGSA 188
Query: 158 SHNASLEVAILRDDFRQNPS-------------------DVMVAVGEPAVMECQPPRGHP 198
A + F Q P+ +V+ G ++C G P
Sbjct: 189 QTKAPWXAGLA--GFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTS-GVP 245
Query: 199 EPTISWKKDGSPLDDKDERITIR--GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAEL 256
P + W KD P+ + ++ G L IT + D G+Y CV + G++ + +L
Sbjct: 246 TPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDF-QL 304
Query: 257 TVLERPSF--VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEI--RDD 312
V P+ +AV D + CEARG P P + W KD LP S + R
Sbjct: 305 RVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGG 364
Query: 313 HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV---KPRDQVVALGRTVT 369
L++ + + D G YTC A N VG AE + L V PP +P GR V
Sbjct: 365 RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVA 424
Query: 370 FQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYIC 428
+C A G+P P + W EG P S+ + G L + + + G Y C
Sbjct: 425 LECVARGHPSPTLSWHHEGL--------PVAESNESRLETDGSVLRLESPGEASSGLYSC 476
Query: 429 QTLNVAGSIITKAYLEVTDVIADRPPP--VIRQGPVNQTVAVDGTFVLSCVATGSPVPTI 486
+ AG + + +EV + PP ++ +G T V L C A+GSPVPTI
Sbjct: 477 VASSPAGEAVLQYSVEV------QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTI 530
Query: 487 LWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 546
W ++G + L I + +L +G + C A+ +G A A +EV G
Sbjct: 531 QWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTA--GAEVEVSVHG 588
Score = 142 bits (359), Expect = 2e-33
Identities = 121/456 (26%), Positives = 190/456 (41%), Gaps = 35/456 (7%)
Query: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 200
DEG+Y C A N GE+ +L+V ++ + P + V +EC G P P
Sbjct: 668 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 724
Query: 201 TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 259
+SW K P+ +++ G L I + SDAG Y CV +N+ G E L V
Sbjct: 725 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 783
Query: 260 ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 314
P PS V V+ C A G P PT+ W KD + +
Sbjct: 784 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 843
Query: 315 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 374
L + A D G Y+CVA + VG+ L V PP + + + V +V +C++
Sbjct: 844 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQS 903
Query: 375 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYICQTL 431
P P + W ++G R V + D + V R+DV G+Y C+ L
Sbjct: 904 HAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 953
Query: 432 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 491
N AG ++ + + +A P +R+ TV LSC G P P I WRKD
Sbjct: 954 NQAGR--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTSLSCECRGVPFPKISWRKD 1008
Query: 492 GVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ---EFG 546
G + + + ++ + +L + A+L G YTC S G ++ +EV +
Sbjct: 1009 GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 1068
Query: 547 VPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 582
P +P PT +++ + E + T++W+
Sbjct: 1069 GPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 1102
Score = 132 bits (333), Expect = 2e-30
Identities = 103/319 (32%), Positives = 143/319 (44%), Gaps = 23/319 (7%)
Query: 37 GNDHGTPIPTSDNDDNSLGYTGSRLRQEDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRP 95
G D GT T++N ++G R+ P P D + G+ L C A G P
Sbjct: 2909 GQDAGTYTCTAEN---AVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSP 2965
Query: 96 TPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG- 154
TP I W T D P + + G R SR D G YVC A N +G
Sbjct: 2966 TPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA---VSREDSGTYVCWAENRVGR 3014
Query: 155 -EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD 213
+AVS E +L+ + S ++ VG ++C RG P P I W KDG PL
Sbjct: 3015 TQAVSFVHVKEAPVLQGEAF---SYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLPLRG 3070
Query: 214 KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAV 273
R ++ G L I T + DAG+Y C+ N +G + +V L + P F P ++ V
Sbjct: 3071 SHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK-KVVILVLQSAPVFQVEPQDMTV 3129
Query: 274 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVA 332
D +C+A G+P PT+ W + L SR D +L + V GD G+Y CVA
Sbjct: 3130 RSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 3189
Query: 333 ENMVGKAEASATLTVQEPP 351
N++G A A A L V+ P
Sbjct: 3190 HNLLGSATARAFLVVRGEP 3208
Score = 132 bits (331), Expect = 4e-30
Identities = 153/585 (26%), Positives = 231/585 (39%), Gaps = 72/585 (12%)
Query: 82 GEPATLNCKAEGRPTPTIEWYK-------GGERVETDKDDPRSHRMLLPSGSLFFLRIVH 134
G L C G PTP +EW K GG ++ +D LRI
Sbjct: 232 GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQ-------------VLRITG 278
Query: 135 GRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPP 194
DEG Y CVA + G+ + + L V + N + + + + V
Sbjct: 279 SHVG--DEGRYQCVAFSPAGQQ-ARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEA 335
Query: 195 RGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESEV 253
RG P P I+W KDG+ L + + RGG+ L + + SDAG Y C +N VG E +
Sbjct: 336 RGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE-KA 394
Query: 254 AELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---GELPKSRY 307
L V P+ RP + +C ARG P PT+ W + E +SR
Sbjct: 395 TRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRL 454
Query: 308 EIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVV-KPRDQVVAL-G 365
E D L++ G Y+CVA + G+A ++ VQ PP +V + QV + G
Sbjct: 455 E-TDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVG 513
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITNVQRSDVG 424
+ + C+A+G+P P I W + G +P + + V+ G L I +V+ G
Sbjct: 514 QPLELPCQASGSPVPTIQWLQNG--------RPAEELAGVQVASQGTTLHIDHVELDHSG 565
Query: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ---TVAVDGTFVLSC---VA 478
+ CQ N AG+ A EV + P + + P+ Q +F +C V
Sbjct: 566 LFACQATNEAGT----AGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVH 621
Query: 479 TG---SPVPTIL--WRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 532
G P P ++ W G L + LQI L D G YTC A+ +G
Sbjct: 622 RGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAG 681
Query: 533 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP----------SKPEVTDVSRNTVTLSWQ 582
E+ ++V P P P + ++ +A P+V+ + SW
Sbjct: 682 ESKREVALKV--LVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWM 739
Query: 583 PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPN 627
+ IE + S++ VA NV T GL+ N
Sbjct: 740 -GVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVN 783
Score = 125 bits (315), Expect = 3e-28
Identities = 138/495 (27%), Positives = 197/495 (39%), Gaps = 64/495 (12%)
Query: 89 CKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCV 148
C G P P + W KG ++ + +L GSLF + S D G Y C
Sbjct: 24 CGTHGTPKPQVTWRKG---PSSEPLHGQPGVAVLEEGSLFLASV-----SPADSGDYECQ 75
Query: 149 ARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWK 205
A N +G + S A L V + +R+D R+ ++V G+ +EC G P P I W
Sbjct: 76 ATNEVG-STSRRAKLVVYVPPSIREDGRK--ANVSGMAGQSLTLECD-ANGFPVPEIVWL 131
Query: 206 KD----GSPL------------DDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGER 249
KD G PL R+ G L + +G+ +
Sbjct: 132 KDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTK 191
Query: 250 ESEVAELTVLER---PSFVKRPSNLAVTVDDSA-----------EFKCEARGDPVPTVRW 295
A L E+ P P+ +V +A E +C G P P V W
Sbjct: 192 APWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEW 251
Query: 296 RKD-DGELPKSRY-EIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH 352
KD LP + ++++D L+I GD G Y CVA + G+ L V PP
Sbjct: 252 TKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPT 311
Query: 353 FVVKPRDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
VA+ V CEA G P P I W ++G+ LL P S+
Sbjct: 312 IWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA--LL-----PTSTKVVYTRGG 364
Query: 411 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV-AVD 469
L + Q SD G Y C+ N G+ L+V PP + G V AV
Sbjct: 365 RQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVY-----VPPTIEGAGGRPYVVKAVA 419
Query: 470 GTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 528
G V L CVA G P PT+ W +G+ V+ + + + VL++ +G Y+C+AS
Sbjct: 420 GRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVAS 479
Query: 529 TPSGEATWSAYIEVQ 543
+P+GEA +EVQ
Sbjct: 480 SPAGEAVLQYSVEVQ 494
Score = 99.8 bits (247), Expect = 2e-20
Identities = 115/428 (26%), Positives = 163/428 (38%), Gaps = 58/428 (13%)
Query: 196 GHPEPTISWKKDGS--PLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEV 253
G P+P ++W+K S PL + + G L + +D+G Y C TN VG S
Sbjct: 28 GTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGS-TSRR 86
Query: 254 AELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD------------ 299
A+L V PS + R +N++ S +C+A G PVP + W KD
Sbjct: 87 AKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGY 146
Query: 300 ------GELPKSRY--EIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP- 350
G++ R E + H +I+ +G G+ + A Q P
Sbjct: 147 GWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFEQFPT 206
Query: 351 PHFVVKP----------RDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 399
PH P +V+ L G V QC +G P P + W ++ L
Sbjct: 207 PHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL------- 259
Query: 400 QSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 458
V + G L IT D G Y C + AG L V PP I
Sbjct: 260 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV------HAPPTIW 313
Query: 459 QGPVNQTVAV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 516
VAV D L C A G P P I W KDG L+ T + LQ+ A+
Sbjct: 314 GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQ 373
Query: 517 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD-VSRN 575
D G YTC AS G A + ++V + P P ++ + +P + V+R
Sbjct: 374 SSDAGVYTCKASNAVGAAEKATRLDV--YVPPTIEGAGGRPYVVKAVAGRPVALECVARG 431
Query: 576 --TVTLSW 581
+ TLSW
Sbjct: 432 HPSPTLSW 439
Score = 87.8 bits (216), Expect = 8e-17
Identities = 80/295 (27%), Positives = 120/295 (40%), Gaps = 30/295 (10%)
Query: 265 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP---KSRYEIRDDHTLKIRKVT 321
+K ++A+TV A C G P P V WRK P + + ++ +L + V+
Sbjct: 7 IKGLGDVALTVGLEAG-GCGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVS 65
Query: 322 AGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA--LGRTVTFQCEATGNPQ 379
D G Y C A N VG A L V PP R V+ G+++T +C+A G P
Sbjct: 66 PADSGDYECQATNEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPV 125
Query: 380 PAIFWRRE--------GSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTL 431
P I W ++ G + Q + + L +Q G Q
Sbjct: 126 PEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQ-- 183
Query: 432 NVAGSIITKA-----------YLEVTDVIADRPPPVIRQGPVNQTVAVDGTFV-LSCVAT 479
GS TKA + PP V+ G + + + G V L C +
Sbjct: 184 -AGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLAGADVELQCWTS 242
Query: 480 GSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSGE 533
G P P + W KD V ++ E+G VL+I + +GD GRY C+A +P+G+
Sbjct: 243 GVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 297
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 208 bits (529), Expect = 4e-53
Identities = 149/478 (31%), Positives = 215/478 (44%), Gaps = 31/478 (6%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
P + PS + E L C+A G P PTI W K G V T +LP G L
Sbjct: 3948 PVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST-----QVLPGGQL 4002
Query: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPA 187
RI H S D G Y+C+A+N G A+ V + D+ G A
Sbjct: 4003 ---RIAHA--SPEDAGNYLCIAKNSAGSAMGKTRL--VVQVPPVIENGLPDLSTTEGSHA 4055
Query: 188 VMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNMV 246
+ C+ RG PEP I+W KDG P+ + + TI+ G+L++ DAG Y C N V
Sbjct: 4056 FLPCKA-RGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 4114
Query: 247 GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR 306
G V LT+L P F P + ++ + D +C ARG P P + W +D + +
Sbjct: 4115 GRARRRV-HLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGV 4173
Query: 307 YEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA-LG 365
E TL+ V+ D G+Y C AEN VG+ +A + + V+E P + +V +G
Sbjct: 4174 SEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAPVLQGEAFSYLVEPVG 4233
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 425
++ C G+P P I W ++G P + S Q G LTI +R D G
Sbjct: 4234 GSIQLDCVVRGDPVPDIHWIKDGL--------PLRGSHLRHQLQNGSLTIHRTERDDAGR 4285
Query: 426 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 485
Y C N G + K + ++ + PV + P + TV L C ATG P PT
Sbjct: 4286 YQCLAENEMG--VAKKVV----ILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPT 4339
Query: 486 ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
I W + G + R++ L +G L + + GD G Y C+A G AT A++ V+
Sbjct: 4340 IEWLQAGQPLRA-SRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVR 4396
Score = 196 bits (498), Expect = 2e-49
Identities = 162/531 (30%), Positives = 232/531 (43%), Gaps = 47/531 (8%)
Query: 44 IPTSDNDD------NSLGYTGSRLRQEDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRPT 96
+ T+D+ D N+ G T R E P I P + VS + A L C+A+G P
Sbjct: 3642 LSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA 3701
Query: 97 PTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEA 156
P + W K +RV D PR +LP GSL ++ D G Y+C+A N G
Sbjct: 3702 PLVSWRK--DRVPLDPRSPRFE--ILPEGSLRIQPVL-----AQDAGHYLCLASNSAG-- 3750
Query: 157 VSHNASLEVAILRDD-FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD 215
S ++ +L +PS++ + PA++ C+ G P+P + W KDG LD +
Sbjct: 3751 -SDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEAS-GSPKPLVVWWKDGQKLDFRL 3808
Query: 216 ERITIR---GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLA 272
++ R L++T D+ ++ CV +N VGE + ++TV P+ ++
Sbjct: 3809 QQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAH-RLYQVTVHVPPTIADDQTDFT 3867
Query: 273 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTC 330
VT+ C + G P PTV W K +L S Y + L+I + G YTC
Sbjct: 3868 VTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTC 3927
Query: 331 VAENMVGKAEASATLTVQEPPHFVVKPRDQVV--ALGRTVTFQCEATGNPQPAIFWRREG 388
A N G A LTVQ P VVKP VV V CEA+G P+P I W++EG
Sbjct: 3928 SARNSAGVAHKHVFLTVQASP--VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEG 3985
Query: 389 SQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDV 448
+ V G L I + D G Y+C N AGS + K L V
Sbjct: 3986 LN--------VATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVV--- 4034
Query: 449 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG 508
+ PPVI G + + L C A GSP P I W KDG VS + + +G
Sbjct: 4035 ---QVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG 4091
Query: 509 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL 559
L ++ + D G YTC A G A ++ + +PV P D +L
Sbjct: 4092 ELLVKNLEGQDAGTYTCTAENAVGRARRRVHLTI--LVLPVFTTLPGDRSL 4140
Score = 192 bits (489), Expect = 2e-48
Identities = 158/510 (30%), Positives = 222/510 (43%), Gaps = 49/510 (9%)
Query: 67 PPRI---VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 123
PP I + L+ GE T+ C G P + W K G + P S R LL
Sbjct: 3310 PPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPL------PLSQRTLL- 3362
Query: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVM 180
GS LRI + D G++ CVA + G A N +L+V + L QN DV+
Sbjct: 3363 HGSGHTLRI--SKVQLADAGIFTCVAASPAGVA-DRNFTLQVQVPPVLEPVEFQN--DVV 3417
Query: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVC 240
V G + C+ RG P P +SW KDG PL + +G L + D+G Y C
Sbjct: 3418 VVRGSLVELPCEA-RGVPLPLVSWMKDGEPLLSQSLE---QGPSLQLEAVGAGDSGTYSC 3473
Query: 241 VGTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 298
V + GE +LTV+E P +P+ L++T E C+A+G P P + W KD
Sbjct: 3474 VAVSEAGEARRHF-QLTVMEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKD 3532
Query: 299 DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
L + R L++R D G YTC+AE+ G E S + VQ PP+ +V PR
Sbjct: 3533 GQALTRLENNSRATRVLRVR-----DAGLYTCLAESPAGAIEKSFRVRVQAPPN-IVGPR 3586
Query: 359 DQVVALGRT---VTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 415
+G + +C P P I W R+G ++ RF L +
Sbjct: 3587 GPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRF-------LQL 3639
Query: 416 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLS 475
+ +D G Y C N AGS +E+ V P IR GP V+V+ T +L
Sbjct: 3640 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTV------PTIRSGPPAVNVSVNQTALLP 3693
Query: 476 CVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEAT 535
C A G P P + WRKD V + + R + L G L+I+ D G Y C+AS +G
Sbjct: 3694 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDR 3753
Query: 536 WSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 565
+ V E P P P++ L P+
Sbjct: 3754 QGRDLRVLE--PPAIAPSPSNLTLTAHTPA 3781
Score = 186 bits (472), Expect = 2e-46
Identities = 156/542 (28%), Positives = 231/542 (42%), Gaps = 56/542 (10%)
Query: 67 PPRIVE--HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I + P++L ++ G P L C A+G P P I W+K G+ + +++ R+ R+L
Sbjct: 3493 PPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQALTRLENNSRATRVLRVR 3552
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
D G+Y C+A + G S V + P VG
Sbjct: 3553 ----------------DAGLYTCLAESPAGAI---EKSFRVRVQAPPNIVGPRGPRFVVG 3593
Query: 185 ---EPAVMECQPPRGHPEPTISWKKDGSPL-DDKDERITIRGGKLMITYTRKSDAGKYVC 240
V+EC P P I+W +DG L +D + RG L + +D+G Y C
Sbjct: 3594 LAPGQLVLECSV-EAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQALSTADSGDYSC 3652
Query: 241 VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300
N G S + + P+ P + V+V+ +A C+A G P P V WRKD
Sbjct: 3653 TARNAAGST-SVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 3711
Query: 301 EL-PKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPR 358
L P+S R+EI + +L+I+ V A D G Y C+A N G L V EPP P
Sbjct: 3712 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 3771
Query: 359 DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNV 418
+ + CEA+G+P+P + W ++G Q L F Q + + + L +T
Sbjct: 3772 NLTLTAHTPALLPCEASGSPKPLVVWWKDG-QKLDFRLQ----QGAYRLLPSNALLLTAP 3826
Query: 419 QRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVA 478
D + C N G + Y V PP I + TV + VL+C +
Sbjct: 3827 GPQDSAQFECVVSNEVGE-AHRLYQVTVHV-----PPTIADDQTDFTVTMMAPVVLTCHS 3880
Query: 479 TGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 538
TG P PT+ W K G + + S + +G L+I A GRYTC A +G A
Sbjct: 3881 TGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHV 3940
Query: 539 YIEVQEFGVPVQPPRPT-------DPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATP 591
++ VQ PV P P+ + L+P E + + R T+T WQ + AT
Sbjct: 3941 FLTVQ--ASPVVKPLPSVVRAVAEEEVLLPC-----EASGIPRPTIT--WQKEGLNVATG 3991
Query: 592 TS 593
S
Sbjct: 3992 VS 3993
Score = 184 bits (467), Expect = 6e-46
Identities = 175/569 (30%), Positives = 246/569 (43%), Gaps = 86/569 (15%)
Query: 44 IPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYK 103
IP S + D+ LG G + ++ TL C++ P PTI WYK
Sbjct: 2631 IPPSISKDDPLGEVGVK---------------EVKTKVNSTLTLECESWAVPPPTIRWYK 2675
Query: 104 GGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE-------- 155
G+ V P S +L G L L+I + S D G Y+CVA N GE
Sbjct: 2676 DGQPVT-----PSSRLQVLGEGRL--LQIQPTQVS--DSGRYLCVATNVAGEDDQDFNVL 2726
Query: 156 ---------AVSHNASLEVAILRDDFRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWK 205
+A+ E+ ++ R ++ V PA + C P P ++W
Sbjct: 2727 IQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDT-NAIPPPDLTWY 2785
Query: 206 KDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF 264
++ PL DE ++GG+ L I R +AG+Y C +N VGE EL VL P
Sbjct: 2786 REDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHY-ELLVLTPPVI 2844
Query: 265 VKRPSNLA--VTVDDSA--EFKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDD-HTLKIR 318
+ L VTV+ S+ +C A G+PVPT+ W ++ P R ++ +D L++
Sbjct: 2845 LGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVS 2904
Query: 319 KVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVA-LGRTVTFQCEATGN 377
D SY CVAEN G AE TL VQ PP +QV A L +V+ C+ +
Sbjct: 2905 TAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAH 2964
Query: 378 PQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSI 437
P P + W ++ SQ L + F + T L + + SD G Y C+ LN AG
Sbjct: 2965 PNPEVTWYKD-SQALSLGEEV------FLLPGTHTLQLGRARLSDSGMYTCEALNAAGRD 3017
Query: 438 ITKAYLEVTDVIADRPPPVIRQGPVNQ----TVAVDGTFVLSCVATGSPVPTILWRKDG- 492
L V PP RQ P V V VLSC P PT+ W KDG
Sbjct: 3018 QKLVQLSVL------VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQ 3071
Query: 493 VLVSTQDSRIKQLENGV-LQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQP 551
LV Q R + L G L+I+ A++ D G Y+C S +GEA V+ F + VQ
Sbjct: 3072 PLVLAQ--RTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEA-------VRTFTLTVQV 3122
Query: 552 PRPTDPNLIPSAPSKPEVTDVSRNTVTLS 580
P PT N P V+ V+ + + L+
Sbjct: 3123 P-PTFEN-----PKTETVSQVAGSPLVLT 3145
Score = 182 bits (462), Expect = 2e-45
Identities = 145/478 (30%), Positives = 203/478 (42%), Gaps = 34/478 (7%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I P + V + TL C A G P P + W+KG + V S + S
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGHQPVS-------SWMGVTVSVD 1937
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
LRI + S D G Y CVA N G + L V + V V P
Sbjct: 1938 GRVLRIEQAQLS--DAGSYRCVASNVAG-STELRYGLRVNVPPRITLPPSLPGPVLVNTP 1994
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDE---RITIRGGKLMITYTRKSDAGKYVCVGT 243
+ C G P PT+ W KDG+P+ ++ G L + R SD+G+Y CV
Sbjct: 1995 VRLTCNAT-GAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAV 2053
Query: 244 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL- 302
+ VGE +V L V PS + N++V ++S +C++ P P + W KD L
Sbjct: 2054 SAVGEDRQDVV-LQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE 2112
Query: 303 PKSRYEIRDDHTL-KIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQV 361
P+ + D L ++ + D G YTC A N G +E L V P F ++ +
Sbjct: 2113 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 2172
Query: 362 -VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT-ITNVQ 419
V G + CE G P P I WR++G P + + VS G L + Q
Sbjct: 2173 TVREGHPTSLSCECRGVPFPKISWRKDGQP------LPGEGAGLQHVSAVGRLLYLGQAQ 2226
Query: 420 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVI---RQGPVNQTVAVDGTFVLSC 476
+ G Y C+ NV G+ LEV PP I R+ P +V DG L C
Sbjct: 2227 LAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIAGPREPPTQVSVVQDGVATLEC 2280
Query: 477 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 534
ATG P PT+ W +DG V + Q + L + A+ TGRY+C+A +G A
Sbjct: 2281 NATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRA 2338
Score = 177 bits (449), Expect = 8e-44
Identities = 146/489 (29%), Positives = 212/489 (43%), Gaps = 44/489 (8%)
Query: 63 QEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLL 122
Q PP I+ ++ V E L C++ P P + W+K G +E PR L
Sbjct: 2066 QVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLE-----PRPGVHLS 2120
Query: 123 PSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVA 182
+L + R D G Y C A N G + H +L V + + + V
Sbjct: 2121 ADKALLQV----DRADVWDAGHYTCEALNQAGHSEKH-YNLNVWVAPVFPLRESHTLTVR 2175
Query: 183 VGEPAVMECQPPRGHPEPTISWKKDGSPLDDKD---ERITIRGGKLMITYTRKSDAGKYV 239
G P + C+ RG P P ISW+KDG PL + + ++ G L + + + G Y
Sbjct: 2176 EGHPTSLSCE-CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYT 2234
Query: 240 CVGTNMVGERESEVAELTVLERPSFV---KRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
C +N+VG S+ +L V P + P+ ++V D A +C A G P PTV W
Sbjct: 2235 CECSNVVG-NSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWE 2293
Query: 297 KDDGELPKSRYEIR---DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHF 353
+ DG+ + ++ +L + + A G Y+CVAEN+ G+AE L+V PP
Sbjct: 2294 R-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPEL 2352
Query: 354 V--VKPRDQV-VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
+ + P + AL +T CEA G P PAI W F + P S +
Sbjct: 2353 IGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRW---------FRGEEPVSPGEDTYLLA 2403
Query: 411 GD--LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAV 468
G L +T Q D G Y C N AG +EV PP I + + + V
Sbjct: 2404 GGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL------VPPSIENEDLEEVIKV 2457
Query: 469 -DG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 526
DG T L C TG P P + W KDG ++ D+ + +LQ+ A L G Y+CI
Sbjct: 2458 LDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCI 2517
Query: 527 ASTPSGEAT 535
A+ GE T
Sbjct: 2518 AANAVGEKT 2526
Score = 177 bits (449), Expect = 8e-44
Identities = 158/512 (30%), Positives = 226/512 (44%), Gaps = 58/512 (11%)
Query: 74 PSD-LIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRI 132
P D ++V G+ A L+C+ + P PT+ WYK G+ + + L G L I
Sbjct: 3038 PQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQ-----RTQALRGGQR--LEI 3090
Query: 133 VHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQ 192
+ S D+G+Y C N GEAV +L V + V G P V+ C
Sbjct: 3091 QEAQVS--DKGLYSCKVSNVAGEAV-RTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCD 3147
Query: 193 PPRGHPEPTISWKKDGSPLDDKDER-ITIRGGKLMITYTRKSDAGKYVCVGTNMVGERES 251
G P PT++W KD P++ + RGG+L ++ + + AG Y CV N E
Sbjct: 3148 VS-GVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARK 3206
Query: 252 EVAELTVLERPSFVKRPSNLA----VTVDDSAEFKCEARGDPVPTVRWRKDDGEL----- 302
+ + VL P R S +A V CEA G P P V W KD L
Sbjct: 3207 DFV-VAVLVAPRI--RSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMG 3263
Query: 303 PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV 362
P R+ + D +L ++ + A D G+YTCVA N G+ T+ V PP + + D
Sbjct: 3264 PHLRFYL-DGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPP-TIKQGADGSG 3321
Query: 363 AL----GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG-DLTITN 417
L G VT C G+P + W ++G P S R + +G L I+
Sbjct: 3322 TLVSRPGELVTMVCPVRGSPPIHVSWLKDG--------LPLPLSQRTLLHGSGHTLRISK 3373
Query: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV---NQTVAVDGTFV- 473
VQ +D G + C + AG L+V + PPV+ PV N V V G+ V
Sbjct: 3374 VQLADAGIFTCVAASPAGVADRNFTLQV------QVPPVLE--PVEFQNDVVVVRGSLVE 3425
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENG-VLQIRYAKLGDTGRYTCIASTPSG 532
L C A G P+P + W KDG + +Q LE G LQ+ GD+G Y+C+A + +G
Sbjct: 3426 LPCEARGVPLPLVSWMKDGEPLLSQ-----SLEQGPSLQLEAVGAGDSGTYSCVAVSEAG 3480
Query: 533 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 564
EA + V E +PT+ +L P AP
Sbjct: 3481 EARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 3512
Score = 176 bits (447), Expect = 1e-43
Identities = 132/481 (27%), Positives = 201/481 (41%), Gaps = 30/481 (6%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I PS+L ++ PA L C+A G P P + W+K G++++ + LLPS +
Sbjct: 3763 PPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQ--QGAYRLLPSNA 3820
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
L D + CV N +GEA H + + +D V + P
Sbjct: 3821 LLLTA-----PGPQDSAQFECVVSNEVGEA--HRLYQVTVHVPPTIADDQTDFTVTMMAP 3873
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGTNM 245
V+ C G P PT+SW K G+ L + + G L I AG+Y C N
Sbjct: 3874 VVLTCHST-GIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNS 3932
Query: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
G V LTV P PS + ++ CEA G P PT+ W+K+ +
Sbjct: 3933 AGVAHKHVF-LTVQASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATG 3991
Query: 306 -RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVAL 364
++ L+I + D G+Y C+A+N G A L VQ PP D
Sbjct: 3992 VSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTE 4051
Query: 365 GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS-RFSVSQTGDLTITNVQRSDV 423
G C+A G+P+P I W ++G QP + +F++ +G+L + N++ D
Sbjct: 4052 GSHAFLPCKARGSPEPNITWDKDG--------QPVSGAEGKFTIQPSGELLVKNLEGQDA 4103
Query: 424 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV 483
G Y C N G + +L + + PV P ++++ + L C A GSP
Sbjct: 4104 GTYTCTAENAVGRARRRVHLTILVL------PVFTTLPGDRSLRLGDRLWLRCAARGSPT 4157
Query: 484 PTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
P I W + V+ S +Q LQ D+G Y C A G +++ V+
Sbjct: 4158 PRIGWTVNDRPVTEGVS--EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVK 4215
Query: 544 E 544
E
Sbjct: 4216 E 4216
Score = 174 bits (440), Expect = 8e-43
Identities = 156/572 (27%), Positives = 238/572 (41%), Gaps = 72/572 (12%)
Query: 52 NSLGYTGSRLRQE-DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGER 107
N +G + L+ E PP+I E P+ + V + ATL C A G+P PT+ W + G+
Sbjct: 2239 NVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQP 2298
Query: 108 VETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI 167
V + L G + R G Y CVA N G A E+++
Sbjct: 2299 VGAELG-----LQLQNQGQSLHVE----RAQAAHTGRYSCVAENLAGRA---ERKFELSV 2346
Query: 168 LRDDFRQNPSD----VMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGG 223
L D + A+ P + C+ G P P I W + P+ ++ + GG
Sbjct: 2347 LVPPELIGDLDPLTNITAALHSPLTLLCEA-MGIPPPAIRWFRGEEPVSPGEDTYLLAGG 2405
Query: 224 -KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDD--SAE 280
L +T T++ D+G Y C+ +N GE + + VL PS + V D +A
Sbjct: 2406 WMLKMTQTQEQDSGLYSCLASNEAGEARRNFS-VEVLVPPSIENEDLEEVIKVLDGQTAH 2464
Query: 281 FKCEARGDPVPTVRWRKDDGELPK--SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGK 338
C G P P + W KD L + + + D L++ + G Y+C+A N VG+
Sbjct: 2465 LMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGE 2524
Query: 339 AEASATLTVQEPPHFVVKPRDQV-----VALGRTVTFQCEATGNPQPAIFWRREGSQNLL 393
L+V P + D V + ++ CEA P P I W ++G+
Sbjct: 2525 KTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMKDGA---- 2580
Query: 394 FSYQPPQSSSRFSVSQ-TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 452
P ++S + T L I N Q+ D G Y C N G + ++EV
Sbjct: 2581 ----PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLI----- 2631
Query: 453 PPPVIRQGPVNQT------VAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLE 506
PP + + P+ + V+ T L C + P PTI W KDG V T SR++ L
Sbjct: 2632 PPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPV-TPSSRLQVLG 2690
Query: 507 NG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPS 565
G +LQI+ ++ D+GRY C+A+ +GE + Q+F V +Q P P
Sbjct: 2691 EGRLLQIQPTQVSDSGRYLCVATNVAGE-------DDQDFNVLIQVP-----------PM 2732
Query: 566 KPEVTDVSRNTVTLSWQPNLNSGATPTSYIIE 597
+V D S LS + G T I+E
Sbjct: 2733 FQKVGDFSAAFEILSREEEARGGVTEYREIVE 2764
Score = 171 bits (434), Expect = 4e-42
Identities = 126/385 (32%), Positives = 175/385 (45%), Gaps = 32/385 (8%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP I DL ++G A L CKA G P P I W K G+ V + PSG
Sbjct: 4037 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVS----GAEGKFTIQPSGE 4092
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEP 186
L ++ + G+ D G Y C A N +G A L + +L F P D + +G+
Sbjct: 4093 LL-VKNLEGQ----DAGTYTCTAENAVGRA-RRRVHLTILVL-PVFTTLPGDRSLRLGDR 4145
Query: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 246
+ C RG P P I W + P+ + G L + D+G YVC N V
Sbjct: 4146 LWLRCAA-RGSPTPRIGWTVNDRPVTEGVSEQD-GGSTLQRAAVSREDSGTYVCWAENRV 4203
Query: 247 GERES----EVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL 302
G ++ V E VL+ +F S L V S + C RGDPVP + W KD L
Sbjct: 4204 GRTQAVSFVHVKEAPVLQGEAF----SYLVEPVGGSIQLDCVVRGDPVPDIHWIKDGLPL 4259
Query: 303 PKS--RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ 360
S R+++++ +L I + D G Y C+AEN +G A+ L +Q P F V+P+D
Sbjct: 4260 RGSHLRHQLQNG-SLTIHRTERDDAGRYQCLAENEMGVAKKVVILVLQSAPVFQVEPQDM 4318
Query: 361 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420
V G V +C+ATG P P I W + G QP ++S R G L + NV+
Sbjct: 4319 TVRSGDDVALRCQATGEPTPTIEWLQAG--------QPLRASRRLRTLPDGSLWLENVET 4370
Query: 421 SDVGYYICQTLNVAGSIITKAYLEV 445
D G Y C N+ GS +A+L V
Sbjct: 4371 GDAGTYDCVAHNLLGSATARAFLVV 4395
Score = 164 bits (414), Expect = 9e-40
Identities = 142/497 (28%), Positives = 204/497 (41%), Gaps = 53/497 (10%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
P++ H S S+G ++C A G PTP I W + + ++ +D R H + G+L
Sbjct: 608 PQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ---EDSRIH--VDAQGTL 662
Query: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSD------VMV 181
I+ G + D G Y C A N +G E L + PS V+V
Sbjct: 663 ----IIQG-VAPEDAGNYSCQATNEVG------TDQETVTLY--YTDPPSVSAVNAVVLV 709
Query: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 241
AVGE AV+ C+ G P P + W + G + E + GKL I ++ DAG Y C
Sbjct: 710 AVGEEAVLVCEAS-GVPPPRVIWYRGGLEMILAPEGSS--SGKLRIPAAQERDAGTYTCR 766
Query: 242 GTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGE 301
N +G+ +E+ +L V P + P ++ V + SA C A G P PTV WR+ DG+
Sbjct: 767 AVNELGDASAEI-QLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 825
Query: 302 L--------PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QEPP 351
SR D L V D Y C A N+ GK +A A L V PP
Sbjct: 826 PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPP 885
Query: 352 HFVVKPRDQVVALGRTVTFQCEA-TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
V G+ V+ C G P P W ++G +P SR S+
Sbjct: 886 QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDG--------RPLPPGSRHSIRAD 937
Query: 411 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 470
G L + + G Y C N AGS +E+ + R P N+ V
Sbjct: 938 GSLHLDRALQEHAGRYSCVATNTAGS--QHRDVELVVQVPPRIHPTATHHITNEGVPAS- 994
Query: 471 TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTP 530
L CVA+G P PTI W K+ ++++ + G L I D G Y C A+
Sbjct: 995 ---LPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNT 1051
Query: 531 SGEATWSAYIEVQEFGV 547
G ++ + V +
Sbjct: 1052 VGFSSQEMRLSVNRLAL 1068
Score = 162 bits (410), Expect = 3e-39
Identities = 148/521 (28%), Positives = 211/521 (40%), Gaps = 49/521 (9%)
Query: 52 NSLGYTGSRLRQEDF-PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERV 108
N +G T R + + PP I E VS G+ TL C A G P P I W K + V
Sbjct: 1282 NEVGSTSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLV 1341
Query: 109 -----------ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV 157
+ HR+L SL F RI G D G+Y C A N G A
Sbjct: 1342 GVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEG-----DSGLYSCRAENQAGTAQ 1396
Query: 158 SHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER 217
L + +V+ G ++C G P P + W KD P+
Sbjct: 1397 RDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTS-GVPTPQVEWTKDRQPVLPGGPH 1455
Query: 218 ITIR--GGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSF--VKRPSNLAV 273
+ ++ G L IT + D G+Y CV + G++ + +L V P+ +AV
Sbjct: 1456 LQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDF-QLRVHAPPTIWGSNETGEVAV 1514
Query: 274 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEI--RDDHTLKIRKVTAGDMGSYTCV 331
D + CEARG P P + W KD LP S + R L++ + + D G YTC
Sbjct: 1515 MEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCK 1574
Query: 332 AENMVGKAEASATLTVQEPPHFVV---KPRDQVVALGRTVTFQCEATGNPQPAIFWRREG 388
A N VG AE + L V PP +P GR V +C A G+P P + W EG
Sbjct: 1575 ASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG 1634
Query: 389 SQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTD 447
P S+ + G L + + + G Y C + AG + + +EV
Sbjct: 1635 L--------PVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEV-- 1684
Query: 448 VIADRPPP--VIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 505
+ PP ++ +G T V L C A+GSPVPTI W ++G
Sbjct: 1685 ----QVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVAS 1740
Query: 506 ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFG 546
+ L I + +L +G + C A+ +G A A +EV G
Sbjct: 1741 QGTTLHIDHVELDHSGLFACQATNEAGTA--GAEVEVSVHG 1779
Score = 162 bits (410), Expect = 3e-39
Identities = 150/519 (28%), Positives = 216/519 (41%), Gaps = 69/519 (13%)
Query: 67 PPRIVEHPSDLIVS--KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I + ++ G+ A L C G P P + W+K G + +H + P
Sbjct: 2443 PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD----AHH-ISPD 2497
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH---NASLEVAILRDDFRQNPSDVMV 181
G L L+++ S G Y C+A N +GE H + L IL +V V
Sbjct: 2498 GVL--LQVLQANLS--SAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTV 2553
Query: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVC 240
V P + C+ P P I+W KDG+P + + G L I +K DAG+Y C
Sbjct: 2554 TVNNPISLICEA-LAFPSPNITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 2612
Query: 241 VGTNMVGERESEVAELTVLERPSFVKRP-------SNLAVTVDDSAEFKCEARGDPVPTV 293
V TN +GE + VL PS K + V+ + +CE+ P PT+
Sbjct: 2613 VVTNELGEAVKNY-HVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTI 2671
Query: 294 RWRKDDGEL-PKSRYEIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
RW KD + P SR ++ + L+I+ D G Y CVA N+ G+ + + +Q PP
Sbjct: 2672 RWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPP 2731
Query: 352 HFV----------VKPRDQVVALGRT----------VTFQCEATGNPQPAIFWRREGSQN 391
F + R++ G T C+ P P + W RE
Sbjct: 2732 MFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED--- 2788
Query: 392 LLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450
QP + SV Q G L I V+ + G Y C+ N G L V
Sbjct: 2789 -----QPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT--- 2840
Query: 451 DRPPPVIRQGPVNQ-----TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 505
PPVI G + TV T L C A G+PVPTI W ++G L + R++ L
Sbjct: 2841 ---PPVIL-GDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG-LPFSPSPRLQVL 2895
Query: 506 ENG-VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ 543
E+G VLQ+ A++ D Y C+A +G A + VQ
Sbjct: 2896 EDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQ 2934
Score = 162 bits (409), Expect = 3e-39
Identities = 129/472 (27%), Positives = 192/472 (40%), Gaps = 45/472 (9%)
Query: 79 VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS---HRMLLPSGSLFFLRIVHG 135
+ + PA L C P P + WY+ +D P S +L G + + +V
Sbjct: 2762 IVENNPAYLYCDTNAIPPPDLTWYR--------EDQPLSAGDEVSVLQGGRVLQIPLVRA 2813
Query: 136 RKSRPDEGVYVCVARNYLGEAVSHNASLEVA--ILRDDFRQNPSDVMVAVGEPAVMECQP 193
+ G Y C A N +GE H L + ++ D + +V V ++C P
Sbjct: 2814 ENA----GRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASSTVSLQC-P 2868
Query: 194 PRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKYVCVGTNMVGERESE 252
G+P PTISW ++G P + G+ L ++ +DA Y+CV N G E +
Sbjct: 2869 ALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE-K 2927
Query: 253 VAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR--YEI 309
+ L V P + ++ S C+ P P V W KD L + +
Sbjct: 2928 LFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLL 2987
Query: 310 RDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQ----VVALG 365
HTL++ + D G YTC A N G+ + L+V PP F PR +V +G
Sbjct: 2988 PGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVG 3047
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD-LTITNVQRSDVG 424
CE P+P + W ++G QP + R + G L I Q SD G
Sbjct: 3048 DKAVLSCETDALPEPTVTWYKDG--------QPLVLAQRTQALRGGQRLEIQEAQVSDKG 3099
Query: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVA--VDGTFVLSCVATGSP 482
Y C+ NVAG + L V + PP + P +TV+ VL+C +G P
Sbjct: 3100 LYSCKVSNVAGEAVRTFTLTV------QVPPTF-ENPKTETVSQVAGSPLVLTCDVSGVP 3152
Query: 483 VPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEA 534
PT+ W KD + V + G LQ+ + G YTC+A EA
Sbjct: 3153 APTVTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEA 3204
Score = 161 bits (408), Expect = 4e-39
Identities = 175/644 (27%), Positives = 246/644 (38%), Gaps = 66/644 (10%)
Query: 5 HVPFLVMISLLSLSPNHLFL----AQLIPDPEDVERGNDHGTPIPTSDNDDNSL------ 54
H P LV S+ S P L L A+L + E GN + S ++ +
Sbjct: 441 HQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVS 500
Query: 55 ----GYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVET 110
G +++ D PP++V P+ + VS GE A L+C+ G + W
Sbjct: 501 RAGTGRAKAQIVVTDPPPQLVPAPN-VTVSPGETAVLSCRVLGEAPYNLTWV-------- 551
Query: 111 DKDDPRSHRMLLPS----GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVA 166
R R+L S L L + D G Y CVA N G AS+ +
Sbjct: 552 -----RDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVT---RASVWLL 603
Query: 167 ILR-DDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRG-GK 224
+ + S + G + C G+P P ISW ++ L + D RI + G
Sbjct: 604 VREAPQVSIHTSSQHFSQGVEVKVSCSAS-GYPTPHISWSRESQALQE-DSRIHVDAQGT 661
Query: 225 LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCE 284
L+I DAG Y C TN VG + E L + PS + + V V + A CE
Sbjct: 662 LIIQGVAPEDAGNYSCQATNEVGT-DQETVTLYYTDPPSVSAVNAVVLVAVGEEAVLVCE 720
Query: 285 ARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASAT 344
A G P P V W + E+ + E L+I D G+YTC A N +G A A
Sbjct: 721 ASGVPPPRVIWYRGGLEMILAP-EGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQ 779
Query: 345 LTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 404
L V P PRD V LGR+ C ATG P P + WRR Q L + SR
Sbjct: 780 LAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGR-GSR 838
Query: 405 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 464
+G L +V D Y+C+ NV G + +A L VT PP + P +
Sbjct: 839 SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVT---GHAPPQIASSAPTVR 895
Query: 465 TVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT 524
+ + V G P+P W KDG + SR +G L + A GRY+
Sbjct: 896 VLEGQPVSLPCIVLAGRPLPERHWLKDGRPL-PPGSRHSIRADGSLHLDRALQEHAGRYS 954
Query: 525 CIASTPSGEATWSAYIEVQEFGVPVQPPR--------------PTDPNLIPSAPSKPEVT 570
C+A+ +G + VQ PPR P + S P +T
Sbjct: 955 CVATNTAGSQHRDVELVVQ------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTIT 1008
Query: 571 DVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENV 614
S P+ N T I + + +G+ T V
Sbjct: 1009 WTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTV 1052
Score = 161 bits (407), Expect = 6e-39
Identities = 159/548 (29%), Positives = 219/548 (39%), Gaps = 69/548 (12%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
PP++ P L V GE LNC AEG P P + W K G ++ P GS
Sbjct: 1119 PPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRG----------PQGS 1168
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDF--RQNPSDVMVAV- 183
+ F I D G Y C A N G +E+ +L S ++ V
Sbjct: 1169 VHFAAI-----RTSDAGRYRCEASNSAGVDA---WEVELRVLEPPHWGADETSGLLERVA 1220
Query: 184 GEPAVMECQPPRGHPEPTISWKKDGS--PLDDKDERITIRGGKLMITYTRKSDAGKYVCV 241
GE A + C P RG P+P ++W+K S PL + + G L + +D+G Y C
Sbjct: 1221 GENASLPC-PARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQ 1279
Query: 242 GTNMVGERESEVAELTVLERPSFVK--RPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD 299
TN VG S A+L V PS + R +N++ S +C+A G PVP + W KD
Sbjct: 1280 ATNEVGS-TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDA 1338
Query: 300 ------------------GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 341
G++ R + + +L ++ GD G Y+C AEN G A+
Sbjct: 1339 QLVGVPLGWAGYGWDLGWGQVGGHRL-LDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQR 1397
Query: 342 SATLTVQEPPHFVVKPRDQVV--ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPP 399
L V PP + Q V G V QC +G P P + W ++ L
Sbjct: 1398 DFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL------- 1450
Query: 400 QSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 458
V + G L IT D G Y C + AG L V PP I
Sbjct: 1451 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRV------HAPPTIW 1504
Query: 459 QGPVNQTVAV--DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 516
VAV D L C A G P P I W KDG L+ T + LQ+ A+
Sbjct: 1505 GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQ 1564
Query: 517 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD-VSRN 575
D G YTC AS G A + ++V + P P ++ + +P + V+R
Sbjct: 1565 SSDAGVYTCKASNAVGAAEKATRLDV--YVPPTIEGAGGRPYVVKAVAGRPVALECVARG 1622
Query: 576 --TVTLSW 581
+ TLSW
Sbjct: 1623 HPSPTLSW 1630
Score = 155 bits (393), Expect = 2e-37
Identities = 142/534 (26%), Positives = 196/534 (36%), Gaps = 83/534 (15%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKG-GERVETDKDDPRSHRMLLP-SG 125
P++ E P D+ V G A L C+A GRP PT+ W +G G+ + R R P SG
Sbjct: 786 PQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSRSRQPDSG 845
Query: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
LFF + + D+ YVC ARN G+ + + + V V G+
Sbjct: 846 VLFFESV-----APEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQ 900
Query: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 245
P + C G P P W KDG PL G L + + AG+Y CV TN
Sbjct: 901 PVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNT 960
Query: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVP-------------- 291
G + +V EL V P ++ A C A G P P
Sbjct: 961 AGSQHRDV-ELVVQVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSR 1019
Query: 292 -------------------------------TVRWRKDDGELPKSR----------YEIR 310
TV + + L +R Y +
Sbjct: 1020 GPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLL 1079
Query: 311 DDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTF 370
+L++ +V GD G Y C A N G A L VQ PP PR V +G +
Sbjct: 1080 PSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDL 1139
Query: 371 QCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQT 430
C A GNP+P + W ++G ++ + PQ S F+ +T SD G Y C+
Sbjct: 1140 NCVAEGNPEPQLSWSKDG---VVLQGRGPQGSVHFAAIRT----------SDAGRYRCEA 1186
Query: 431 LNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG-TFVLSCVATGSPVPTILWR 489
N AG + L V + PP V G L C A G+P P + WR
Sbjct: 1187 SNSAGVDAWEVELRVLE-----PPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWR 1241
Query: 490 KDGVLVSTQ-DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 542
K + LE G L + D+G Y C A+ G + A + V
Sbjct: 1242 KGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV 1295
Score = 155 bits (393), Expect = 2e-37
Identities = 148/534 (27%), Positives = 216/534 (40%), Gaps = 43/534 (8%)
Query: 67 PPRI--VEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
PP I ++ V + L C+A G PTP I W+K G + P S +++
Sbjct: 1500 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALL------PTSTKVVYTR 1553
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVMVAV 183
G ++ GR D GVY C A N +G A + + V + P V
Sbjct: 1554 GGR---QLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVA 1610
Query: 184 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDE-RITIRGGKLMITYTRKSDAGKYVCVG 242
G P +EC RGHP PT+SW +G P+ + +E R+ G L + ++ +G Y CV
Sbjct: 1611 GRPVALECVA-RGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA 1669
Query: 243 TNMVGERESEVA-ELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDD-- 299
++ GE + + E+ V + + + V E C+A G PVPT++W ++
Sbjct: 1670 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRP 1729
Query: 300 GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV--QEPPHFVVKP 357
E TL I V G + C A N G A A ++V + P + P
Sbjct: 1730 AEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 1789
Query: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQS------SSRFSVSQTG 411
Q G A +P W L+ + P S + S
Sbjct: 1790 IGQY-HWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPP 1848
Query: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGT 471
L I V D G Y C N+AG + L+V PP I GPVN+ V + +
Sbjct: 1849 PLQIEKVDLRDEGIYTCAATNLAGESKREVALKVL------VPPNIEPGPVNKAVLENAS 1902
Query: 472 FVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPS 531
L C+A+G P P + W K VS+ ++ VL+I A+L D G Y C+AS +
Sbjct: 1903 VTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 1962
Query: 532 GEATWSAYIEVQEFGVPVQ-PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPN 584
G +G+ V PPR T P PS P V R T + P+
Sbjct: 1963 GSTE-------LRYGLRVNVPPRITLP---PSLPGPVLVNTPVRLTCNATGAPS 2006
Score = 153 bits (387), Expect = 1e-36
Identities = 148/519 (28%), Positives = 212/519 (40%), Gaps = 71/519 (13%)
Query: 71 VEHPSDLIVSKG---------EPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
V+ P L+V++G +P L C+A G P PTI+W + G E + +
Sbjct: 1684 VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEE-----LAGVQV 1738
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181
G+ + V S G++ C A N G A A +EV++ + P + V
Sbjct: 1739 ASQGTTLHIDHVELDHS----GLFACQATNEAGTA---GAEVEVSVHGE---WAPGVLEV 1788
Query: 182 AVGE-----------PAVMECQPP--RG---HPEPTI--SWKKDGSPLDDKDERITIRGG 223
+G+ PA C PP RG HP+P + W GS L + I +
Sbjct: 1789 PIGQYHWGXEHHSSFPAA--CDPPVHRGWGAHPKPPLVEGWCSPGS-LWGEPTGIPVAYS 1845
Query: 224 ---KLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAE 280
L I D G Y C TN+ GE + EVA L VL P+ P N AV + S
Sbjct: 1846 LPPPLQIEKVDLRDEGIYTCAATNLAGESKREVA-LKVLVPPNIEPGPVNKAVLENASVT 1904
Query: 281 FKCEARGDPVPTVRWRKDDGELPKSRY----EIRDDHTLKIRKVTAGDMGSYTCVAENMV 336
+C A G P P V W K G P S + D L+I + D GSY CVA N+
Sbjct: 1905 LECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 1962
Query: 337 GKAEASATLTVQEPPHFVVKPR-DQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 395
G E L V PP + P V + V C ATG P P + W ++G+
Sbjct: 1963 GSTELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNP----- 2017
Query: 396 YQPPQSSSRFSVSQTGD-LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPP 454
P + V G LT+ + + SD G Y C ++ G L+V P
Sbjct: 2018 -VSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMP 2070
Query: 455 PVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRY 514
P I +N +V + + L C + P P + W KDG + + + +LQ+
Sbjct: 2071 PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDR 2130
Query: 515 AKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPR 553
A + D G YTC A +G + + + + PV P R
Sbjct: 2131 ADVWDAGHYTCEALNQAGHS--EKHYNLNVWVAPVFPLR 2167
Score = 153 bits (386), Expect = 2e-36
Identities = 147/490 (30%), Positives = 206/490 (42%), Gaps = 53/490 (10%)
Query: 82 GEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPD 141
GE A+L C A G P P + W KG ++ + +L GSLF + S D
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPS---SEPLHGQPGVAVLEEGSLFLASV-----SPAD 1272
Query: 142 EGVYVCVARNYLGEAVSHNASLEVAI---LRDDFRQNPSDVMVAVGEPAVMECQPPRGHP 198
G Y C A N +G + S A L V + +R+D R+ ++V G+ +EC G P
Sbjct: 1273 SGDYECQATNEVG-STSRRAKLVVYVPPSIREDGRK--ANVSGMAGQSLTLECDA-NGFP 1328
Query: 199 EPTISWKKD----GSPL------------DDKDERITIRGGKLMITYTRKSDAGKYVCVG 242
P I W KD G PL R+ G L ++ D+G Y C
Sbjct: 1329 VPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRA 1388
Query: 243 TNMVGERESEVAELTVLERPSFVKRPSNLAVT--VDDSAEFKCEARGDPVPTVRWRKD-D 299
N G + + L VL PS + + V E +C G P P V W KD
Sbjct: 1389 ENQAGTAQRDF-HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQ 1447
Query: 300 GELPKSRY-EIRDD-HTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 357
LP + ++++D L+I GD G Y CVA + G+ L V PP
Sbjct: 1448 PVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSN 1507
Query: 358 RDQVVAL--GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTI 415
VA+ V CEA G P P I W ++G+ LL P S+ L +
Sbjct: 1508 ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGA--LL-----PTSTKVVYTRGGRQLQL 1560
Query: 416 TNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTV-AVDGTFV- 473
Q SD G Y C+ N G+ L+V PP + G V AV G V
Sbjct: 1561 GRAQSSDAGVYTCKASNAVGAAEKATRLDVYV-----PPTIEGAGGRPYVVKAVAGRPVA 1615
Query: 474 LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533
L CVA G P PT+ W +G+ V+ + + + VL++ +G Y+C+AS+P+GE
Sbjct: 1616 LECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGE 1675
Query: 534 ATWSAYIEVQ 543
A +EVQ
Sbjct: 1676 AVLQYSVEVQ 1685
Score = 142 bits (359), Expect = 2e-33
Identities = 121/456 (26%), Positives = 190/456 (41%), Gaps = 35/456 (7%)
Query: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEP 200
DEG+Y C A N GE+ +L+V ++ + P + V +EC G P P
Sbjct: 1859 DEGIYTCAATNLAGES-KREVALKV-LVPPNIEPGPVNKAVLENASVTLECLAS-GVPPP 1915
Query: 201 TISWKKDGSPLDD-KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL 259
+SW K P+ +++ G L I + SDAG Y CV +N+ G E L V
Sbjct: 1916 DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYG-LRVN 1974
Query: 260 ERPSFVKRPSNLA-VTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE----IRDDHT 314
P PS V V+ C A G P PT+ W KD + +
Sbjct: 1975 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 2034
Query: 315 LKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEA 374
L + A D G Y+CVA + VG+ L V PP + + + V +V +C++
Sbjct: 2035 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALECQS 2094
Query: 375 TGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV---GYYICQTL 431
P P + W ++G R V + D + V R+DV G+Y C+ L
Sbjct: 2095 HAMPPPVLSWWKDGRP----------LEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 2144
Query: 432 NVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD 491
N AG ++ + + +A P +R+ TV LSC G P P I WRKD
Sbjct: 2145 NQAGH--SEKHYNLNVWVAPVFP--LRESHT-LTVREGHPTSLSCECRGVPFPKISWRKD 2199
Query: 492 GVLVSTQDSRIKQLE--NGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQ---EFG 546
G + + + ++ + +L + A+L G YTC S G ++ +EV +
Sbjct: 2200 GQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIA 2259
Query: 547 VPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQ 582
P +P PT +++ + E + T++W+
Sbjct: 2260 GPREP--PTQVSVVQDGVATLECNATGKPPPTVTWE 2293
Score = 138 bits (347), Expect = 5e-32
Identities = 133/488 (27%), Positives = 187/488 (38%), Gaps = 87/488 (17%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS-HRMLLPSG 125
PPRI + I ++G PA+L C A G P PTI W K ET+ R H + G
Sbjct: 975 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTK-----ETNALTSRGPHYNVSKEG 1029
Query: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
+L + S D G YVC A N +G + ++ ++V
Sbjct: 1030 TLLI-----AQPSAQDAGAYVCTATNTVGFS-------------------SQEMRLSVNR 1065
Query: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 245
A+ + W++ G + G L + + D+G Y C +N
Sbjct: 1066 LALSK-----------YVWEEYG----------LLPSGSLRLAQVQVGDSGHYECTASNP 1104
Query: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKS 305
G L V P P L V V ++ + C A G+P P + W K DG + +
Sbjct: 1105 AGSASHRYV-LGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSK-DGVVLQG 1162
Query: 306 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVV--A 363
R H IR D G Y C A N G L V EPPH+ ++
Sbjct: 1163 RGPQGSVHFAAIR---TSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLERV 1219
Query: 364 LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDV 423
G + C A G P+P + WR+ S +P +V + G L + +V +D
Sbjct: 1220 AGENASLPCPARGTPKPQVTWRKGPSS------EPLHGQPGVAVLEEGSLFLASVSPADS 1273
Query: 424 GYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG--PVNQTVAVDGTFVLSCVATGS 481
G Y CQ N GS +A L V PP IR+ N + + L C A G
Sbjct: 1274 GDYECQATNEVGSTSRRAKLVV------YVPPSIREDGRKANVSGMAGQSLTLECDANGF 1327
Query: 482 PVPTILWRKDGVLVST--------------QDSRIKQLENG-VLQIRYAKLGDTGRYTCI 526
PVP I+W KD LV Q + L+ G L + GD+G Y+C
Sbjct: 1328 PVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCR 1387
Query: 527 ASTPSGEA 534
A +G A
Sbjct: 1388 AENQAGTA 1395
Score = 132 bits (333), Expect = 2e-30
Identities = 103/319 (32%), Positives = 143/319 (44%), Gaps = 23/319 (7%)
Query: 37 GNDHGTPIPTSDNDDNSLGYTGSRLRQEDFP-PRIVEHPSDLIVSKGEPATLNCKAEGRP 95
G D GT T++N ++G R+ P P D + G+ L C A G P
Sbjct: 4100 GQDAGTYTCTAEN---AVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSP 4156
Query: 96 TPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG- 154
TP I W T D P + + G R SR D G YVC A N +G
Sbjct: 4157 TPRIGW--------TVNDRPVTEGVSEQDGGSTLQRAA---VSREDSGTYVCWAENRVGR 4205
Query: 155 -EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD 213
+AVS E +L+ + S ++ VG ++C RG P P I W KDG PL
Sbjct: 4206 TQAVSFVHVKEAPVLQGEAF---SYLVEPVGGSIQLDCVV-RGDPVPDIHWIKDGLPLRG 4261
Query: 214 KDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAV 273
R ++ G L I T + DAG+Y C+ N +G + +V L + P F P ++ V
Sbjct: 4262 SHLRHQLQNGSLTIHRTERDDAGRYQCLAENEMGVAK-KVVILVLQSAPVFQVEPQDMTV 4320
Query: 274 TVDDSAEFKCEARGDPVPTVRWRKDDGELPKSR-YEIRDDHTLKIRKVTAGDMGSYTCVA 332
D +C+A G+P PT+ W + L SR D +L + V GD G+Y CVA
Sbjct: 4321 RSGDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVA 4380
Query: 333 ENMVGKAEASATLTVQEPP 351
N++G A A A L V+ P
Sbjct: 4381 HNLLGSATARAFLVVRGEP 4399
>gi|109150416 peroxidasin [Homo sapiens]
Length = 1479
Score = 206 bits (523), Expect = 2e-52
Identities = 140/400 (35%), Positives = 186/400 (46%), Gaps = 21/400 (5%)
Query: 150 RNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGS 209
R G +V+ E+ R P D V G C+ G+P+P I W ++ +
Sbjct: 226 RRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRA-EGNPKPEIIWLRNNN 284
Query: 210 PLDDK-DERITIRG-GKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL---ERPSF 264
L K D R+ + G LMI T+++D G Y C+ N+ GE +++ L RP+F
Sbjct: 285 ELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTF 344
Query: 265 VKRPSNLAVTVDDSAEFKCEARGDPVPTVRW-RKDDGELPKS-RYEIRDDHTLKIRKVTA 322
V +P N V V +S +C A G P P + W R D LP R I L I+ V
Sbjct: 345 VIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQ 404
Query: 323 GDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAI 382
GD G Y C A N + A+A + VQ P F V P+D+VV G+TV FQCEA GNP P I
Sbjct: 405 GDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVI 464
Query: 383 FWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAY 442
W + GSQ + R V +G L I+ V D G Y CQ +N+ GS A+
Sbjct: 465 AWTKGGSQLSV--------DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAH 516
Query: 443 LEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRI 502
L + R PV P + TV V L C + G P P I W KDGV V T+ +
Sbjct: 517 L----TVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQV-TESGKF 571
Query: 503 KQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEV 542
G L I D GRY C+A G A+ S + V
Sbjct: 572 HISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSV 611
Score = 190 bits (483), Expect = 9e-48
Identities = 131/400 (32%), Positives = 180/400 (45%), Gaps = 32/400 (8%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
PRI P D V+ G C+AEG P P I W + + D S LL G+L
Sbjct: 246 PRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTD---SRLNLLDDGTL 302
Query: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEV--AILRDDFRQNPSDVMVAVGE 185
D+G+Y C+A+N GE + +L + R F P + V VGE
Sbjct: 303 MI-----QNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGE 357
Query: 186 PAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIR-GGKLMITYTRKSDAGKYVCVGT 243
+EC GHP P ISW + D +PL D R+ I G L I + D+G+Y C T
Sbjct: 358 SVTLECS-ATGHPPPRISWTRGDRTPL-PVDPRVNITPSGGLYIQNVVQGDSGEYACSAT 415
Query: 244 NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP 303
N + + A + V P F P + V + +F+CEA+G+P P + W K +L
Sbjct: 416 NNI-DSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLS 474
Query: 304 -KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE--PPHFVVKPRDQ 360
R+ + TL+I V D G Y C A N++G + A LTVQ P F P D
Sbjct: 475 VDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDT 534
Query: 361 VVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQR 420
V +G V C + G P+PAI W ++G Q S +F +S G LTI +V
Sbjct: 535 TVEVGANVQLPCSSQGEPEPAITWNKDGVQ--------VTESGKFHISPEGFLTINDVGP 586
Query: 421 SDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 460
+D G Y C N GS V+ V++ P V R G
Sbjct: 587 ADAGRYECVARNTIGS------ASVSMVLSVNVPDVSRNG 620
Score = 143 bits (360), Expect = 2e-33
Identities = 114/413 (27%), Positives = 173/413 (41%), Gaps = 27/413 (6%)
Query: 260 ERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK---SRYEIRDDHTLK 316
ERP P + VT ++ F C A G+P P + W +++ EL SR + DD TL
Sbjct: 244 ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM 303
Query: 317 IRKVTAGDMGSYTCVAENMVGKAEAS-ATLTV---QEPPHFVVKPRDQVVALGRTVTFQC 372
I+ D G Y C+A+N+ G+ + TL P FV++P++ V +G +VT +C
Sbjct: 304 IQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLEC 363
Query: 373 EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLN 432
ATG+P P I W R G + P R +++ +G L I NV + D G Y C N
Sbjct: 364 SATGHPPPRISWTR-GDRT------PLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATN 416
Query: 433 VAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDG 492
S+ A++ V + P P ++ V T C A G+P P I W K G
Sbjct: 417 NIDSVHATAFIIVQAL------PQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGG 470
Query: 493 VLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPP 552
+S D R L +G L+I L D G+Y C A G A++ VQ PV
Sbjct: 471 SQLSV-DRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFAS 529
Query: 553 RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE 612
P+D + A + + ++W G T H S + T+ +
Sbjct: 530 IPSDTTVEVGANVQLPCSSQGEPEPAITWN---KDGVQVTE---SGKFHISPEGFLTIND 583
Query: 613 NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVD 665
+ + + N I V + + D S+ DP ++ VD
Sbjct: 584 VGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVD 636
Score = 100 bits (249), Expect = 1e-20
Identities = 69/205 (33%), Positives = 94/205 (45%), Gaps = 12/205 (5%)
Query: 343 ATLTVQE----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQP 398
AT+T +E P +P+D V G TV F C A GNP+P I W R ++ +
Sbjct: 234 ATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSM----- 288
Query: 399 PQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIR 458
++ SR ++ G L I N Q +D G Y C NVAG + T+ RP VI+
Sbjct: 289 -KTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQ 347
Query: 459 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 518
P N V V + L C ATG P P I W + D R+ +G L I+ G
Sbjct: 348 --PQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQG 405
Query: 519 DTGRYTCIASTPSGEATWSAYIEVQ 543
D+G Y C A+ +A+I VQ
Sbjct: 406 DSGEYACSATNNIDSVHATAFIIVQ 430
>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
Length = 1026
Score = 205 bits (522), Expect = 3e-52
Identities = 216/847 (25%), Positives = 338/847 (39%), Gaps = 102/847 (12%)
Query: 68 PRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
P ++ PS ++ S+ + LNC+ +G P P I W G V+T D R +
Sbjct: 26 PIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMD----FRYSVVE 81
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
GSL +++ D G Y C A N G VS A L+ A L + + S V V G
Sbjct: 82 GSL----LINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRG 137
Query: 185 EPAVMECQPPRGHPEPTISWKKDGSP-LDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 243
+ V+ C PP E + +W + P D ++ G L I KSD G Y CV T
Sbjct: 138 QGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVT 197
Query: 244 NMVGERESEVAELTVLER---------PSF-VKRPSNLAVTVDDSAEFKCEARGDPVPTV 293
N V + ++ R P V+ P + + + +C A G+PVPT+
Sbjct: 198 NTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTI 257
Query: 294 RWRKDDGE-LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH 352
WR+ DG+ + + + + L+I D G Y CVAEN GK A LT P+
Sbjct: 258 IWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPN 317
Query: 353 FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 412
++ K D VA+ V ++C+A G P+P W + G +P + R + Q G
Sbjct: 318 WIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNG--------EPLLTRDRIQIEQ-GT 368
Query: 413 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 472
L IT V SD G Y C N G I + A L V V D ++++ + V V G
Sbjct: 369 LNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTL---VKVGGEV 425
Query: 473 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 532
V+ C SP P W+K G + ++ RI E+G L+I D G YTCIA+ G
Sbjct: 426 VIECKPKASPKPVYTWKK-GRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFG 484
Query: 533 EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPT 592
A+ + + V++ + PP D + S +VT + +W + N
Sbjct: 485 TASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTW--SFNGHLIDF 542
Query: 593 SYIIEAFSHASG--SSWQTVAENVKTETSAIKGLKPNAIYLFLVR-------AANAYGIS 643
+ F G S+ + N++ LK Y+ +V+ AA +
Sbjct: 543 DRDGDHFERVGGQDSAGDLMIRNIQ--------LKHAGKYVCMVQTSVDRLSAAADLIVR 594
Query: 644 DPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TVDQQSQ 702
P + V ++ T+ + + +++ + + + V W V +
Sbjct: 595 GPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYV----IQARTPFSVGWQAVSTVPE 650
Query: 703 YIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGAD 762
I G G N W+ +E RT A N + I + +RP
Sbjct: 651 LIDGKTFTATVVGLN----PWVEYEFRTVAANVIGIGE---------PSRP--------- 688
Query: 763 SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY--------- 813
SE + +T E P P VS G+ + ++++W+ PE+ QNG Y
Sbjct: 689 SEKR--RTEEALPEVTP--ANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGK 744
Query: 814 KVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDA 873
+W L + + D S + + P + V+V G G S P + A
Sbjct: 745 MIWML------TVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFS-PTTVVYSA 797
Query: 874 HGNPVSP 880
P P
Sbjct: 798 EEEPTKP 804
Score = 204 bits (520), Expect = 4e-52
Identities = 216/780 (27%), Positives = 352/780 (45%), Gaps = 105/780 (13%)
Query: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASL---EVAILRDDFR------- 173
+G+L+ ++ + D G Y CV N V+++ L ILR+D
Sbjct: 176 TGNLYIAKV-----EKSDVGNYTCVVTN----TVTNHKVLGPPTPLILRNDGVMGEYEPK 226
Query: 174 ---QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITY 229
Q P V A G +EC G+P PTI W++ DG P+ K R G L I
Sbjct: 227 IEVQFPETVPTAKGATVKLECFA-LGNPVPTIIWRRADGKPIARKARRHK-SNGILEIPN 284
Query: 230 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 289
++ DAG Y CV N G+ + +LT +P+++++ +++ V ++++ ++C+A G P
Sbjct: 285 FQQEDAGLYECVAENSRGKNVAR-GQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRP 343
Query: 290 VPTVRWRKDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
PT +W K+ GE L + R +I + TL I V D G Y C+AEN G ++A L+V
Sbjct: 344 KPTYKWLKN-GEPLLTRDRIQI-EQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSV 401
Query: 348 -QEPPHF--VVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 404
P F + R +V +G V +C+ +P+P W++ +++L + + R
Sbjct: 402 IAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKK--GRDIL------KENER 453
Query: 405 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 464
++S+ G+L I NV +SD G Y C N G+ + L V D P + P +
Sbjct: 454 ITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKD------PTRVMVPPSSM 507
Query: 465 TVAVDGTFVLSCVATGSPVPTIL--WRKDGVLVSTQDS-----RIKQLEN-GVLQIRYAK 516
V V + VL C T I+ W +G L+ R+ ++ G L IR +
Sbjct: 508 DVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQ 567
Query: 517 LGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNT 576
L G+Y C+ T + +A + V+ PP P P A + E+TD T
Sbjct: 568 LKHAGKYVCMVQTSVDRLSAAADLIVRG------PPGP------PEAVTIDEITDT---T 612
Query: 577 VTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYL 631
LSW+P ++ + T Y+I+A + S WQ V+ + KT T+ + GL P Y
Sbjct: 613 AQLSWRPGPDNHSPITMYVIQARTPFS-VGWQAVSTVPELIDGKTFTATVVGLNPWVEYE 671
Query: 632 FLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSI 691
F AAN GI +PS+ S+ +T++ LP V V G S S +
Sbjct: 672 FRTVAANVIGIGEPSRPSEKRRTEEALPE---VTPANVSGGGG------------SKSEL 716
Query: 692 EVHW-TVDQQSQYIQ--GYKILYRPSGANHGESDWLVFEVRTPAKNSVVI--PDLRKGVN 746
+ W TV ++ Q + GY + +RP +G+ W++ + + + V +
Sbjct: 717 VITWETVPEELQNGRGFGYVVAFRP----YGKMIWMLTVLASADASRYVFRNESVHPFSP 772
Query: 747 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQ 806
+E+K F N+ +G S + EE P+ PP ++ + T I V W P E +
Sbjct: 773 FEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPP--ASIFARSLSATDIEVFWASPLEKNR 830
Query: 807 NGMVQEYKVWCLGNETRYHINKTVD--GSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKS 864
G +Q Y+V +E + + + G+ S I L + Y + V A AG+G S
Sbjct: 831 -GRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSS 889
Score = 151 bits (381), Expect = 6e-36
Identities = 128/422 (30%), Positives = 187/422 (44%), Gaps = 39/422 (9%)
Query: 41 GTPIPTSDNDDNSLGYTGSRLRQEDFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTI 99
G P P +D +G ++ P+I V+ P + +KG L C A G P PTI
Sbjct: 207 GPPTPLILRNDGVMG---------EYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTI 257
Query: 100 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 159
W + + K R H+ S L I + ++ D G+Y CVA N G+ V+
Sbjct: 258 IWRRADGKPIARK--ARRHK------SNGILEIPNFQQE--DAGLYECVAENSRGKNVAR 307
Query: 160 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 219
A + ++ Q +D+ VA+ E EC+ G P+PT W K+G PL +D RI
Sbjct: 308 GQLTFYA--QPNWIQKINDIHVAMEENVFWECKA-NGRPKPTYKWLKNGEPLLTRD-RIQ 363
Query: 220 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE-RPSF----VKRPSNLAVT 274
I G L IT SDAG Y C+ N G S AEL+V+ P F +KR + V
Sbjct: 364 IEQGTLNITIVNLSDAGMYQCLAENKHGVIFSN-AELSVIAVGPDFSRTLLKRVT--LVK 420
Query: 275 VDDSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAE 333
V +C+ + P P W+K L ++ R I +D L+I VT D GSYTC+A
Sbjct: 421 VGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIAT 480
Query: 334 NMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 393
N G A ++ L V++P +V P V +G ++ C+ T + I + + +L+
Sbjct: 481 NHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLI 540
Query: 394 -FSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADR 452
F GDL I N+Q G Y+C + A D+I
Sbjct: 541 DFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAA-----DLIVRG 595
Query: 453 PP 454
PP
Sbjct: 596 PP 597
>gi|222352127 sidekick 2 [Homo sapiens]
Length = 2172
Score = 204 bits (518), Expect = 7e-52
Identities = 227/856 (26%), Positives = 347/856 (40%), Gaps = 106/856 (12%)
Query: 79 VSKGEPATLNC-KAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 137
VS GE A + + P P + W++ G ++ P S + +L L V
Sbjct: 124 VSHGEAAVIRAPRIASFPQPQVTWFRDGRKIP-----PSSRIAITLENTLVILSTV---- 174
Query: 138 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM-------------VAVG 184
PD G Y A N + N + + L + P+D + VA
Sbjct: 175 -APDAGRYYVQAVN---DKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGT 230
Query: 185 EPAVMECQP-PRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 243
+EC R + I WKKDG L I+ +L I SDAG Y C
Sbjct: 231 SEVTLECVANARPLIKLHIIWKKDGVLLSGG---ISDHNRRLTIPNPTGSDAGYYECEAV 287
Query: 244 NMVGERESEV--AELTVLERPSFVKRPS-NLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300
S V A L+VLE P FVK P ++ ++ + C+A+G P P++ W KD
Sbjct: 288 LRSSSVPSVVRGAYLSVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDAA 347
Query: 301 --ELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE-PPHFVVK 356
E+ K +R+ R+D L+I + D G + C A N G+ + S L V P+
Sbjct: 348 VVEVEKLTRFRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSIAPNITRG 407
Query: 357 PRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTIT 416
P D V G +V CE +G P+PAI W++ S Q P RF+ ++G L I+
Sbjct: 408 PLDSTVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLP----RFTPLESGSLLIS 463
Query: 417 NVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSC 476
SD G Y C N G + +A ++ R I + P +Q+V + C
Sbjct: 464 PTHISDAGTYTCLATNSRG--VDEASADLVVWARTR----ITKPPQDQSVIKGTQASMVC 517
Query: 477 VATGSPVPTI--LWRKDGVLVSTQDS-RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGE 533
T P TI +W KDG + T+ RI+ NG L I GD G YTC + G
Sbjct: 518 GVTHDPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGN 577
Query: 534 ATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVT--DVSRNTVTLSWQPNLNSGATP 591
+ SA++ V++ +P AP P T V R + L+W + +
Sbjct: 578 DSRSAHLRVRQ---------------LPHAPEHPVATLSTVERRAINLTWTKPFDGNSPL 622
Query: 592 TSYIIEAFSHASGSSWQTVAENV--KTETSAIKGLKPNAIYLFLVRAANAYGISDPSQIS 649
YI+E + + W + +V K + +KGL P Y F + A N G S+ +
Sbjct: 623 IRYILE--MSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVNDVGKGQFSKDT 680
Query: 650 DPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW---TVDQQSQYIQG 706
+ V + PT+ Q + + ++ SI + W Q+ ++G
Sbjct: 681 ERVSLPEEPPTA------PPQNVIASG---------RTNQSIMIQWQPPPESHQNGILKG 725
Query: 707 YKILYRPSGANHGESDWLVFEVRTPAK-NSVVIPDLRKGVNYEIKARPFFNEFQGADSEI 765
Y I Y +G G F+ T A N++++ DL NYEI+ + + G S
Sbjct: 726 YIIRYCLAGLPVGYQ----FKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSSK 781
Query: 766 KFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYH 825
TL+ P+ PP V N T I +W P NG+ Q YK+ E
Sbjct: 782 VTEWTLQGVPTVPPGNVHAEAT--NSTTIRFTWNAPSPQFINGINQGYKLIAWEPEQEEE 839
Query: 826 INKTVDGSTF--SVVIPFLVPGIR----YSVEVAASTGAGSGVKSEPQFIQLDAHGNPVS 879
+ F S+ + F V G++ Y V T G G +S PQ ++ H +
Sbjct: 840 VTMVTARPNFQDSIHVGF-VSGLKKFTEYFTSVLCFTTPGDGPRSTPQLVR--THEDVPG 896
Query: 880 PEDQVSLAQQISDVVK 895
P +S ++ + +K
Sbjct: 897 PVGHLSFSEILDTSLK 912
Score = 195 bits (496), Expect = 3e-49
Identities = 220/871 (25%), Positives = 338/871 (38%), Gaps = 98/871 (11%)
Query: 63 QEDFPPRIVEHPSDLIVS-KGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
Q+D P P V +G L C AEG +W + + +R +
Sbjct: 21 QDDVSPYFKTEPVRTQVHLEGNRLVLTCMAEGSWPLEFKWLHNNRELTKFSLE---YRYM 77
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181
+ S R G Y C+ RN +G + ++VA + F + V
Sbjct: 78 ITS------------LDRTHAGFYRCIVRNRMGALLQRQTEVQVAYM-GSFEEGEKHQSV 124
Query: 182 AVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCV 241
+ GE AV+ P+P ++W +DG + L+I T DAG+Y
Sbjct: 125 SHGEAAVIRAPRIASFPQPQVTWFRDGRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQ 184
Query: 242 GTNMVG--ERESEVAELTVLE--------RPSFVKRPSNLAVTVDDS-AEFKCEARGDPV 290
N + S+ LTV P+ + P N +V S +C A P+
Sbjct: 185 AVNDKNGDNKTSQPITLTVENVGGPADPIAPTIIIPPKNTSVVAGTSEVTLECVANARPL 244
Query: 291 PTVR--WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA---ENMVGKAEASATL 345
+ W+KD L + + L I T D G Y C A + V A L
Sbjct: 245 IKLHIIWKKDGVLLSGGISD--HNRRLTIPNPTGSDAGYYECEAVLRSSSVPSVVRGAYL 302
Query: 346 TVQEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 404
+V EPP FV +P + A + + V C+A G P P+I W ++ + + +R
Sbjct: 303 SVLEPPQFVKEPERHITAEMEKVVDIPCQAKGVPPPSITWYKDA------AVVEVEKLTR 356
Query: 405 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQ 464
F G L I+ + D G + C N AG + T YL VT + P I +GP++
Sbjct: 357 FRQRNDGGLQISGLVPDDTGMFQCFARNAAGEVQTSTYLAVTSI-----APNITRGPLDS 411
Query: 465 TVAVDGTFVLSCVATGSPVPTILWRKDGVLV---STQDSRIKQLENGVLQIRYAKLGDTG 521
TV + VL+C +G+P P I W+K ++ S Q R LE+G L I + D G
Sbjct: 412 TVIDGMSVVLACETSGAPRPAITWQKGERILASGSVQLPRFTPLESGSLLISPTHISDAG 471
Query: 522 RYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSW 581
YTC+A+ G SA + V +PP+ A VT R T+ W
Sbjct: 472 TYTCLATNSRGVDEASADLVVWARTRITKPPQDQSVIKGTQASMVCGVTHDPRVTIRYIW 531
Query: 582 QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYG 641
+ + + T + I + S QT + ++ T T + N R+A+
Sbjct: 532 EKDGATLGTESHPRIRLDRNGSLHISQTWSGDIGTYTCRVISAGGND-----SRSAHLRV 586
Query: 642 ISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQS 701
P PV T + + ++ + GN+ L + +L S WTV
Sbjct: 587 RQLPHAPEHPVATLSTV-ERRAINLTWTKPFDGNSPLIRY---ILEMSENNAPWTV---- 638
Query: 702 QYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGA 761
L+ V P SV + L +Y+ + + +G
Sbjct: 639 ----------------------LLASV-DPKATSVTVKGLVPARSYQFRLCAVNDVGKGQ 675
Query: 762 DSEIKFAKTL-EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV-WCL- 818
S+ +L EE P+APPQ V S +I++ WQPPPE QNG+++ Y + +CL
Sbjct: 676 FSKDTERVSLPEEPPTAPPQNVIASGR--TNQSIMIQWQPPPESHQNGILKGYIIRYCLA 733
Query: 819 GNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPV 878
G Y D ++++ L+ Y +EVAA AG GV S + + G P
Sbjct: 734 GLPVGYQFKNITDADVNNLLLEDLIIWTNYEIEVAAYNSAGLGVYSS-KVTEWTLQGVPT 792
Query: 879 SPEDQVSLAQQISDVVK------QPAFIAGI 903
P V S ++ P FI GI
Sbjct: 793 VPPGNVHAEATNSTTIRFTWNAPSPQFINGI 823
Score = 91.3 bits (225), Expect = 7e-18
Identities = 90/338 (26%), Positives = 141/338 (41%), Gaps = 55/338 (16%)
Query: 561 PSAPSKPEVT--DVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET 618
P PS+P V DV +V LSW+P + G +P Y W + +V
Sbjct: 1400 PQPPSRPMVQQEDVRARSVLLSWEPG-SDGLSPVRYYTIQTRELPSGRWALHSASVSHNA 1458
Query: 619 SA--IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 676
S+ + LKP Y F V+A N G S+ S+ S+ + T P
Sbjct: 1459 SSFIVDRLKPFTSYKFRVKATNDIGDSEFSEESESLTTLQAAPDEA-------------- 1504
Query: 677 VLHLHNPTVLS-----SSSIEVHW---TVDQQSQYIQGYKILYRP-----------SGAN 717
PT+LS ++S+ + W D+ + + G++I YR G N
Sbjct: 1505 ------PTILSVTPHTTTSVLIRWQPPAEDKINGILLGFRIRYRELLYEGLRGFTLRGIN 1558
Query: 718 HGESDWL----VFEVRTPAKNSVV---IPDLRKGVNYEIKARPFFNEFQGADSEIKFAKT 770
+ + W ++ +R ++ S+ + +L K YEI+ + +G S +
Sbjct: 1559 NPGATWAELTSMYSMRNLSRPSLTQYELDNLNKHRRYEIRMSVYNAVGEGPSSPPQEVFV 1618
Query: 771 LEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYHINK 828
E P+A P+ V V + T + V+W+PPP D+QNG +Q YK+ W K
Sbjct: 1619 GEAVPTAAPRNVVV--HGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVK 1676
Query: 829 TVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 866
T+ + SV + L Y V VAA AG G +S P
Sbjct: 1677 TLFLAENSVKLKNLTGYTAYMVSVAAFNAAGDGPRSTP 1714
Score = 82.4 bits (202), Expect = 3e-15
Identities = 90/388 (23%), Positives = 150/388 (38%), Gaps = 41/388 (10%)
Query: 505 LENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAP 564
L N L+ R L YT + + + GVP + P P P
Sbjct: 946 LPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQVSASTISSGVPPELPGP---------P 996
Query: 565 SKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHA--SGSSWQTV---AENVKTETS 619
+ ++++ +VTL ++P + + + +++EA G W + + +
Sbjct: 997 TNLGISNIGPRSVTLQFRPGYDGKTSISRWLVEAQVGVVGEGEEWLLIHQLSNEPDARSM 1056
Query: 620 AIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 679
+ L P Y F +R N G S PSQ S ++T P ++ A +
Sbjct: 1057 EVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPP------------DMAPANVS 1104
Query: 680 LHNPTVLSSSSIEVHWTVDQQSQY-----IQGYKILYRPSGANHGESDWLVFEVRTPAKN 734
L S +S+ + W + +Y GYKI Y S HG++ L V+ +
Sbjct: 1105 LR---TASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSD-GHGKT--LSHVVQDRVER 1158
Query: 735 SVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAI 794
I DL + Y ++ + F G S+ +T E PS+ P V+ +++
Sbjct: 1159 DYTIEDLEEWTEYRVQVQAFNAIGSGPWSQTVVGRTRESVPSSGPTNVSALAT--TSSSM 1216
Query: 795 LVSWQPPPEDTQNGMVQEYKVWC--LGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEV 852
LV W PE +NG+V YKV ++T+ S+ S + L + Y V+V
Sbjct: 1217 LVRWSEVPEADRNGLVLGYKVMYKEKDSDTQPRFWLVEGNSSRSAQLTGLGKYVLYEVQV 1276
Query: 853 AASTGAGSGVKSEPQFIQLDAHGNPVSP 880
A T G G S P ++ P P
Sbjct: 1277 LAFTRIGDGSPSHPPILERTLDDVPGPP 1304
Score = 76.6 bits (187), Expect = 2e-13
Identities = 199/867 (22%), Positives = 294/867 (33%), Gaps = 127/867 (14%)
Query: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
T + L P I P D V G L C+ G P P I W K GER+
Sbjct: 391 TSTYLAVTSIAPNITRGPLDSTVIDGMSVVLACETSGAPRPAITWQK-GERILASGSVQL 449
Query: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNP 176
L SGSL D G Y C+A N G V ++ V R + P
Sbjct: 450 PRFTPLESGSLLI-----SPTHISDAGTYTCLATNSRG--VDEASADLVVWARTRITKPP 502
Query: 177 SDVMVAVGEPAVMECQPPRGHPEPTIS--WKKDGSPL-DDKDERITI-RGGKLMITYTRK 232
D V G A M C P TI W+KDG+ L + RI + R G L I+ T
Sbjct: 503 QDQSVIKGTQASMVCGVTH-DPRVTIRYIWEKDGATLGTESHPRIRLDRNGSLHISQTWS 561
Query: 233 SDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPT 292
D G Y C G +S A L V + P + P TV+ A
Sbjct: 562 GDIGTYTC-RVISAGGNDSRSAHLRVRQLPHAPEHPVATLSTVERRA-----------IN 609
Query: 293 VRWRKD-DGELPKSRY--EIRDDH---------------TLKIRKVTAGDMGSYTCVAEN 334
+ W K DG P RY E+ +++ ++ ++ + + A N
Sbjct: 610 LTWTKPFDGNSPLIRYILEMSENNAPWTVLLASVDPKATSVTVKGLVPARSYQFRLCAVN 669
Query: 335 MVGKAEASA-TLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLL 393
VGK + S T V P P V+A GRT +Q+++
Sbjct: 670 DVGKGQFSKDTERVSLPEEPPTAPPQNVIASGRT---------------------NQSIM 708
Query: 394 FSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP 453
+QPP S + + + G + + VGY Q N+ + + LE + +
Sbjct: 709 IQWQPPPESHQNGILK-GYIIRYCLAGLPVGY---QFKNITDADVNNLLLEDLIIWTNYE 764
Query: 454 PPVIRQGPVNQTVAVDGT--FVLSCVATGSPVPTILWRKDGVLVS-TQDSRIKQLENGVL 510
V V + L V T P + + T ++ Q NG+
Sbjct: 765 IEVAAYNSAGLGVYSSKVTEWTLQGVPTVPPGNVHAEATNSTTIRFTWNAPSPQFINGIN 824
Query: 511 QIRYAKLG----DTGRYTCIASTP-----------SGEATWSAYI-EVQEFGVPVQPPRP 554
Q Y + T + + P SG ++ Y V F P PR
Sbjct: 825 Q-GYKLIAWEPEQEEEVTMVTARPNFQDSIHVGFVSGLKKFTEYFTSVLCFTTPGDGPRS 883
Query: 555 TDPNLIPSAPSKP------EVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQ 608
T P L+ + P +++ ++ +SWQ T Y I + ++
Sbjct: 884 T-PQLVRTHEDVPGPVGHLSFSEILDTSLKVSWQEPGEKNGILTGYRISWEEYNRTNTRV 942
Query: 609 TVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQ 668
T T + GL Y V A + G Q+S + V P G
Sbjct: 943 THYLPNVTLEYRVTGLTALTTYTIEVAAMTSKG---QGQVSASTISSGVPPELPGPPTNL 999
Query: 669 VQRELG-NAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFE 727
+G +V P +SI W V+ Q + GE +WL+
Sbjct: 1000 GISNIGPRSVTLQFRPGYDGKTSIS-RWLVEAQVGVV------------GEGE-EWLLIH 1045
Query: 728 --VRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSE-IKFAKTLEEAPSAPPQGVTV 784
P S+ +PDL Y + R S+ + +TL+ P P V
Sbjct: 1046 QLSNEPDARSMEVPDLNPFTCYSFRMRQVNIVGTSPPSQPSRKIQTLQAPPDMAP--ANV 1103
Query: 785 SKNDGNGTAILVSWQPPPEDTQNGMVQE--YKVWCLGNE----TRYHINKTVDGSTFSVV 838
S + T++ + W P PE NG + YK+ ++ T H+ D
Sbjct: 1104 SLRTASETSLWLRWMPLPEMEYNGNPESVGYKIKYSRSDGHGKTLSHV--VQDRVERDYT 1161
Query: 839 IPFLVPGIRYSVEVAASTGAGSGVKSE 865
I L Y V+V A GSG S+
Sbjct: 1162 IEDLEEWTEYRVQVQAFNAIGSGPWSQ 1188
Score = 51.2 bits (121), Expect = 8e-06
Identities = 63/278 (22%), Positives = 117/278 (42%), Gaps = 31/278 (11%)
Query: 546 GVPVQPP---RPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHA 602
G P PP R D +P P +V +V L WQP +Y I +
Sbjct: 1285 GSPSHPPILERTLDD--VPGPPMGILFPEVRTTSVRLIWQPPAAPNGIILAYQITHRLNT 1342
Query: 603 SGSSWQTV---AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLP 659
+ ++ TV A + + T+ GLKP ++YLF + A G + ++ V T +
Sbjct: 1343 TTANTATVEVLAPSARQYTAT--GLKPESVYLFRITAQTRKGWGEAAEAL--VVTTEKRD 1398
Query: 660 TSQGVDHKQVQRE--LGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYKILYRPSGAN 717
Q VQ+E +VL P S + ++T+ Q++ + + + +
Sbjct: 1399 RPQPPSRPMVQQEDVRARSVLLSWEPGSDGLSPVR-YYTI--QTRELPSGRWALHSASVS 1455
Query: 718 HGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSA 777
H S ++V ++ + +KA + + ++ E + TL+ AP
Sbjct: 1456 HNASSFIVDRLKP-----------FTSYKFRVKATNDIGDSEFSE-ESESLTTLQAAPDE 1503
Query: 778 PPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV 815
P ++V+ + T++L+ WQPP ED NG++ +++
Sbjct: 1504 APTILSVTPH--TTTSVLIRWQPPAEDKINGILLGFRI 1539
Score = 50.1 bits (118), Expect = 2e-05
Identities = 73/317 (23%), Positives = 118/317 (37%), Gaps = 39/317 (12%)
Query: 562 SAPSKPEVTDVSRNTVTLSWQPNL--NSGATPTSYIIEAFSHASGSSWQTVAENVKTETS 619
+AP V + + ++W+P + Y I + G+ + V E S
Sbjct: 1625 AAPRNVVVHGATATQLDVTWEPPPLDSQNGDIQGYKIYFWEAQRGNLTERVKTLFLAENS 1684
Query: 620 A-IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTS-QGVDHKQVQRELGNAV 677
+K L Y+ V A NA G P +TQ P++ V +
Sbjct: 1685 VKLKNLTGYTAYMVSVAAFNAAG-DGPRSTPTQGQTQQAAPSAPSSVKFSE--------- 1734
Query: 678 LHLHNPTVLSSSSIEVHWTVDQ-QSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSV 736
L+++S+ V W Q + ++GY+++Y P G S + +V+ + +
Sbjct: 1735 --------LTTTSVNVSWEAPQFPNGILEGYRLVYEPCSPVDGVSKIVTVDVKGNSPLWL 1786
Query: 737 VIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAP-PQGVTVSKNDGNGTAIL 795
+ DL +GV Y + R + EI+ T AP P GV + +AI
Sbjct: 1787 KVKDLAEGVTYRFRIRAKTFTY---GPEIEANVTTGPGEGAPGPPGVPIIVR--YSSAIA 1841
Query: 796 VSWQPPPEDTQNGMVQEYKVWCLGNETRY------HINKTVDGSTFSVVIPFLVPGIRYS 849
+ W D G + Y + ++ I K V TFS+ I L PG+ Y
Sbjct: 1842 IHWS--SGDPGKGPITRYVIEARPSDEGLWDILIKDIPKEVSSYTFSMDI--LKPGVSYD 1897
Query: 850 VEVAASTGAGSGVKSEP 866
V A G G S P
Sbjct: 1898 FRVIAVNDYGFGTPSSP 1914
Score = 40.0 bits (92), Expect = 0.019
Identities = 34/121 (28%), Positives = 48/121 (39%), Gaps = 9/121 (7%)
Query: 545 FGVPVQPPRPTDPNLIPSAPSKPEVTDVSR--NTVTLSWQPNLNSGATPTSYIIEAFSHA 602
+G ++ T P AP P V + R + + + W T Y+IEA
Sbjct: 1808 YGPEIEANVTTGPG--EGAPGPPGVPIIVRYSSAIAIHWSSGDPGKGPITRYVIEARPSD 1865
Query: 603 SGSSWQTVAENVKTETSA----IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVL 658
G W + +++ E S+ + LKP Y F V A N YG PS S V Q
Sbjct: 1866 EGL-WDILIKDIPKEVSSYTFSMDILKPGVSYDFRVIAVNDYGFGTPSSPSQSVPAQKAN 1924
Query: 659 P 659
P
Sbjct: 1925 P 1925
Score = 32.3 bits (72), Expect = 3.9
Identities = 56/230 (24%), Positives = 93/230 (40%), Gaps = 38/230 (16%)
Query: 536 WSAY-IEVQEFGVPVQPPRPTDPN-----LIPSAPSKPEVTDVSRNTVTLSWQ-PNLNSG 588
++AY + V F PR T PSAPS + ++++ +V +SW+ P +G
Sbjct: 1693 YTAYMVSVAAFNAAGDGPRSTPTQGQTQQAAPSAPSSVKFSELTTTSVNVSWEAPQFPNG 1752
Query: 589 ATPTSYII-EAFSHASGSSWQTVAENVKTETS---AIKGLKPNAIYLFLVRAAN-AYGIS 643
++ E S G S + V +VK + +K L Y F +RA YG
Sbjct: 1753 ILEGYRLVYEPCSPVDGVS-KIVTVDVKGNSPLWLKVKDLAEGVTYRFRIRAKTFTYGPE 1811
Query: 644 DPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLS-SSSIEVHWTV-DQQS 701
+ ++ + P GV P ++ SS+I +HW+ D
Sbjct: 1812 IEANVT--TGPGEGAPGPPGV------------------PIIVRYSSAIAIHWSSGDPGK 1851
Query: 702 QYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPD-LRKGVNYEIK 750
I Y I RPS + G D L+ ++ + D L+ GV+Y+ +
Sbjct: 1852 GPITRYVIEARPS--DEGLWDILIKDIPKEVSSYTFSMDILKPGVSYDFR 1899
>gi|221316760 L1 cell adhesion molecule isoform 3 precursor [Homo
sapiens]
Length = 1248
Score = 204 bits (518), Expect = 7e-52
Identities = 224/865 (25%), Positives = 356/865 (41%), Gaps = 95/865 (10%)
Query: 52 NSLGYTGS---RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 108
N LG S RL E P E + V +GE L C P ++ + +
Sbjct: 113 NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKIL 172
Query: 109 ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 168
+D+ + + +G+L+F ++ + + Y+C A + +++ +
Sbjct: 173 HIKQDERVT---MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVK 225
Query: 169 RDD----------FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER 217
+ F N S +VA+ G+P V+EC G P PTI W + P+ +R
Sbjct: 226 ATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DR 282
Query: 218 ITIRGGK--LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 275
+T + L + + D G+Y C+ N +G +TV P ++ +P +
Sbjct: 283 VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGP 341
Query: 276 DDSAEFKCEARGDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 332
++A C+ +G P P V WR + EL K + L + V D C A
Sbjct: 342 GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEA 401
Query: 333 ENMVGKAEASATLTVQEPPHFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
N G A+A + V + P ++ +Q + G T C+A G P P++ W E
Sbjct: 402 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 461
Query: 391 NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450
+L RF G L I ++Q +D G Y C N ++ A L+V D
Sbjct: 462 TVL-------QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ 514
Query: 451 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLEN 507
I QGP + +C A+ P P+I WR DG L DS +E+
Sbjct: 515 ------ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED 568
Query: 508 GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKP 567
G L I D G Y+C+AST A + V V P P P L+ S
Sbjct: 569 GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS----- 616
Query: 568 EVTDVSRNTVTLSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKP 626
++ ++++ V +SW P + A Y IE + W ++ + +TS L P
Sbjct: 617 DLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSP 676
Query: 627 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 686
Y F V A N YG +PS +S+ V T + P VD K E N V+
Sbjct: 677 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI-------- 728
Query: 687 SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVN 746
+ + W +D + +Q Y++ +RP G W V P +V+ + V
Sbjct: 729 --TWKPLRW-MDWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVP 778
Query: 747 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPED 804
YEIK + ++ +G + ++ + E+ P A P +G+ + N +A+LV W+P
Sbjct: 779 YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLA 834
Query: 805 TQNGMVQEYKV--WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAAST 856
G ++ Y V W G++ ++ HI+K V +T SV++ L P Y +EV A
Sbjct: 835 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN 894
Query: 857 GAGSGVKSEPQFIQLDAHGNPVSPE 881
G GSG SE F G P PE
Sbjct: 895 GRGSGPASE--FTFSTPEGVPGHPE 917
Score = 191 bits (486), Expect = 4e-48
Identities = 148/509 (29%), Positives = 227/509 (44%), Gaps = 35/509 (6%)
Query: 67 PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
PP I E P L+V + +L C+A G+P W + G + ++ + SG
Sbjct: 29 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 88
Query: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
S F + + ++ +G+Y C A N LG A+SH L ++ V V GE
Sbjct: 89 S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 147
Query: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 240
V+ C PP I W +DER+T+ + G L SD Y+C
Sbjct: 148 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 207
Query: 241 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 289
GT + ++E +L V S + R L + S+ +C A G P
Sbjct: 208 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 265
Query: 290 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348
PT++W + G +P R ++ + TL++ KV D G Y C+AEN +G A + +TV+
Sbjct: 266 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 325
Query: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
P+++ KP+ + G T C+ G PQP + WR G + ++ +
Sbjct: 326 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKYRI- 379
Query: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT-VA 467
Q G L ++NVQ SD C+ N G ++ AY+ V + P ++ NQT +A
Sbjct: 380 QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQTYMA 433
Query: 468 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 526
V G T L C A G+PVP++ W + QD R NG L IR + DTGRY C+
Sbjct: 434 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCL 493
Query: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 555
A+ T A ++V++ Q PR T
Sbjct: 494 AANDQNNVTIMANLKVKDATQITQGPRST 522
Score = 174 bits (441), Expect = 6e-43
Identities = 201/825 (24%), Positives = 338/825 (40%), Gaps = 87/825 (10%)
Query: 65 DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
D PR++ S L+ +G+P L C AEG PTPTI+W + + D+ ++H
Sbjct: 232 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 291
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 180
L L++ D+G Y C+A N LG A ++ ++E A + P +
Sbjct: 292 LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 338
Query: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 238
GE A ++CQ +G P+P ++W+ +G P+++ KD++ I+ G L+++ + SD
Sbjct: 339 YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 397
Query: 239 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 296
C N G + A + V++ P+ + N +A C+A G PVP+V+W
Sbjct: 398 QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 456
Query: 297 KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354
+DG L R+ + TL IR + A D G Y C+A N A L V++
Sbjct: 457 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 516
Query: 355 VKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 412
PR + G VTF C+A+ +P QP+I WR +G Q S ++ + + G
Sbjct: 517 QGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-EDGR 570
Query: 413 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 472
L I ++ SD G Y C + ++A L V V GPV + V D
Sbjct: 571 LVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSDLHL 620
Query: 473 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIASTPS 531
+ S P + D + E + K+ T + +P
Sbjct: 621 LTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPY 677
Query: 532 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQPN-- 584
T+ + ++G P +P ++ + P A + DV + ++W+P
Sbjct: 678 VHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 735
Query: 585 LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 644
++ A Y ++ + WQ + V + Y V+A N+ G
Sbjct: 736 MDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGP 793
Query: 645 PSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VDQQS 701
Q++ G D+ Q A+ L +L+SS++ V W + Q
Sbjct: 794 EPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLAQVK 837
Query: 702 QYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFFNEF 758
+++GY + Y G+ S + + V PA SV++ LR +Y ++ + F
Sbjct: 838 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 897
Query: 759 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEYKVW 816
G SE F+ T E P P + + T++L+ WQPP G V Y
Sbjct: 898 SGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL 953
Query: 817 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 861
G + + N D + + L P +RY ++ A+T G G
Sbjct: 954 DEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 997
>gi|13435353 L1 cell adhesion molecule isoform 2 precursor [Homo
sapiens]
Length = 1253
Score = 204 bits (518), Expect = 7e-52
Identities = 224/865 (25%), Positives = 356/865 (41%), Gaps = 95/865 (10%)
Query: 52 NSLGYTGS---RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 108
N LG S RL E P E + V +GE L C P ++ + +
Sbjct: 118 NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKIL 177
Query: 109 ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 168
+D+ + + +G+L+F ++ + + Y+C A + +++ +
Sbjct: 178 HIKQDERVT---MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVK 230
Query: 169 RDD----------FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER 217
+ F N S +VA+ G+P V+EC G P PTI W + P+ +R
Sbjct: 231 ATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DR 287
Query: 218 ITIRGGK--LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 275
+T + L + + D G+Y C+ N +G +TV P ++ +P +
Sbjct: 288 VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGP 346
Query: 276 DDSAEFKCEARGDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 332
++A C+ +G P P V WR + EL K + L + V D C A
Sbjct: 347 GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEA 406
Query: 333 ENMVGKAEASATLTVQEPPHFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
N G A+A + V + P ++ +Q + G T C+A G P P++ W E
Sbjct: 407 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466
Query: 391 NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450
+L RF G L I ++Q +D G Y C N ++ A L+V D
Sbjct: 467 TVL-------QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ 519
Query: 451 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLEN 507
I QGP + +C A+ P P+I WR DG L DS +E+
Sbjct: 520 ------ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED 573
Query: 508 GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKP 567
G L I D G Y+C+AST A + V V P P P L+ S
Sbjct: 574 GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS----- 621
Query: 568 EVTDVSRNTVTLSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKP 626
++ ++++ V +SW P + A Y IE + W ++ + +TS L P
Sbjct: 622 DLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSP 681
Query: 627 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 686
Y F V A N YG +PS +S+ V T + P VD K E N V+
Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI-------- 733
Query: 687 SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVN 746
+ + W +D + +Q Y++ +RP G W V P +V+ + V
Sbjct: 734 --TWKPLRW-MDWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVP 783
Query: 747 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPED 804
YEIK + ++ +G + ++ + E+ P A P +G+ + N +A+LV W+P
Sbjct: 784 YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLA 839
Query: 805 TQNGMVQEYKV--WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAAST 856
G ++ Y V W G++ ++ HI+K V +T SV++ L P Y +EV A
Sbjct: 840 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN 899
Query: 857 GAGSGVKSEPQFIQLDAHGNPVSPE 881
G GSG SE F G P PE
Sbjct: 900 GRGSGPASE--FTFSTPEGVPGHPE 922
Score = 191 bits (486), Expect = 4e-48
Identities = 148/509 (29%), Positives = 227/509 (44%), Gaps = 35/509 (6%)
Query: 67 PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
PP I E P L+V + +L C+A G+P W + G + ++ + SG
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
S F + + ++ +G+Y C A N LG A+SH L ++ V V GE
Sbjct: 94 S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 152
Query: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 240
V+ C PP I W +DER+T+ + G L SD Y+C
Sbjct: 153 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 212
Query: 241 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 289
GT + ++E +L V S + R L + S+ +C A G P
Sbjct: 213 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270
Query: 290 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348
PT++W + G +P R ++ + TL++ KV D G Y C+AEN +G A + +TV+
Sbjct: 271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 330
Query: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
P+++ KP+ + G T C+ G PQP + WR G + ++ +
Sbjct: 331 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKYRI- 384
Query: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT-VA 467
Q G L ++NVQ SD C+ N G ++ AY+ V + P ++ NQT +A
Sbjct: 385 QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQTYMA 438
Query: 468 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 526
V G T L C A G+PVP++ W + QD R NG L IR + DTGRY C+
Sbjct: 439 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCL 498
Query: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 555
A+ T A ++V++ Q PR T
Sbjct: 499 AANDQNNVTIMANLKVKDATQITQGPRST 527
Score = 174 bits (441), Expect = 6e-43
Identities = 201/825 (24%), Positives = 338/825 (40%), Gaps = 87/825 (10%)
Query: 65 DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
D PR++ S L+ +G+P L C AEG PTPTI+W + + D+ ++H
Sbjct: 237 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 296
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 180
L L++ D+G Y C+A N LG A ++ ++E A + P +
Sbjct: 297 LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 343
Query: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 238
GE A ++CQ +G P+P ++W+ +G P+++ KD++ I+ G L+++ + SD
Sbjct: 344 YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 402
Query: 239 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 296
C N G + A + V++ P+ + N +A C+A G PVP+V+W
Sbjct: 403 QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 461
Query: 297 KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354
+DG L R+ + TL IR + A D G Y C+A N A L V++
Sbjct: 462 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 521
Query: 355 VKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 412
PR + G VTF C+A+ +P QP+I WR +G Q S ++ + + G
Sbjct: 522 QGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-EDGR 575
Query: 413 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 472
L I ++ SD G Y C + ++A L V V GPV + V D
Sbjct: 576 LVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSDLHL 625
Query: 473 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIASTPS 531
+ S P + D + E + K+ T + +P
Sbjct: 626 LTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPY 682
Query: 532 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQPN-- 584
T+ + ++G P +P ++ + P A + DV + ++W+P
Sbjct: 683 VHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 740
Query: 585 LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 644
++ A Y ++ + WQ + V + Y V+A N+ G
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGP 798
Query: 645 PSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VDQQS 701
Q++ G D+ Q A+ L +L+SS++ V W + Q
Sbjct: 799 EPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLAQVK 842
Query: 702 QYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFFNEF 758
+++GY + Y G+ S + + V PA SV++ LR +Y ++ + F
Sbjct: 843 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 759 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEYKVW 816
G SE F+ T E P P + + T++L+ WQPP G V Y
Sbjct: 903 SGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL 958
Query: 817 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 861
G + + N D + + L P +RY ++ A+T G G
Sbjct: 959 DEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 1002
>gi|4557707 L1 cell adhesion molecule isoform 1 precursor [Homo
sapiens]
Length = 1257
Score = 204 bits (518), Expect = 7e-52
Identities = 224/865 (25%), Positives = 356/865 (41%), Gaps = 95/865 (10%)
Query: 52 NSLGYTGS---RLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERV 108
N LG S RL E P E + V +GE L C P ++ + +
Sbjct: 118 NKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGESVVLPCNPPPSAEPLRIYWMNSKIL 177
Query: 109 ETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL 168
+D+ + + +G+L+F ++ + + Y+C A + +++ +
Sbjct: 178 HIKQDERVT---MGQNGNLYFANVL----TSDNHSDYICHAHFPGTRTIIQKEPIDLRVK 230
Query: 169 RDD----------FRQNPSDVMVAV-GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER 217
+ F N S +VA+ G+P V+EC G P PTI W + P+ +R
Sbjct: 231 ATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIA-EGFPTPTIKWLRPSGPMPA--DR 287
Query: 218 ITIRGGK--LMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 275
+T + L + + D G+Y C+ N +G +TV P ++ +P +
Sbjct: 288 VTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSAR-HAYYVTVEAAPYWLHKPQSHLYGP 346
Query: 276 DDSAEFKCEARGDPVPTVRWRKDD---GELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVA 332
++A C+ +G P P V WR + EL K + L + V D C A
Sbjct: 347 GETARLDCQVQGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVTQCEA 406
Query: 333 ENMVGKAEASATLTVQEPPHFVVKPRDQ--VVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
N G A+A + V + P ++ +Q + G T C+A G P P++ W E
Sbjct: 407 RNRHGLLLANAYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWLDEDGT 466
Query: 391 NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450
+L RF G L I ++Q +D G Y C N ++ A L+V D
Sbjct: 467 TVL-------QDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQ 519
Query: 451 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPV--PTILWRKDGV-LVSTQDSRIKQLEN 507
I QGP + +C A+ P P+I WR DG L DS +E+
Sbjct: 520 ------ITQGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRDLQELGDSDKYFIED 573
Query: 508 GVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKP 567
G L I D G Y+C+AST A + V V P P P L+ S
Sbjct: 574 GRLVIHSLDYSDQGNYSCVASTELDVVESRAQLLV------VGSPGPV-PRLVLS----- 621
Query: 568 EVTDVSRNTVTLSWQPNLNSGATPTSYIIE-AFSHASGSSWQTVAENVKTETSAIKGLKP 626
++ ++++ V +SW P + A Y IE + W ++ + +TS L P
Sbjct: 622 DLHLLTQSQVRVSWSPAEDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSP 681
Query: 627 NAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 686
Y F V A N YG +PS +S+ V T + P VD K E N V+
Sbjct: 682 YVHYTFRVTAINKYGPGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVI-------- 733
Query: 687 SSSSIEVHWTVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVN 746
+ + W +D + +Q Y++ +RP G W V P +V+ + V
Sbjct: 734 --TWKPLRW-MDWNAPQVQ-YRVQWRPQGT---RGPWQEQIVSDP---FLVVSNTSTFVP 783
Query: 747 YEIKARPFFNEFQGADSEIKFAKTLEEAPSAPP--QGVTVSKNDGNGTAILVSWQPPPED 804
YEIK + ++ +G + ++ + E+ P A P +G+ + N +A+LV W+P
Sbjct: 784 YEIKVQAVNSQGKGPEPQVTIGYSGEDYPQAIPELEGIEIL----NSSAVLVKWRPVDLA 839
Query: 805 TQNGMVQEYKV--WCLGNETRY---HINK---TVDGSTFSVVIPFLVPGIRYSVEVAAST 856
G ++ Y V W G++ ++ HI+K V +T SV++ L P Y +EV A
Sbjct: 840 QVKGHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFN 899
Query: 857 GAGSGVKSEPQFIQLDAHGNPVSPE 881
G GSG SE F G P PE
Sbjct: 900 GRGSGPASE--FTFSTPEGVPGHPE 922
Score = 191 bits (486), Expect = 4e-48
Identities = 148/509 (29%), Positives = 227/509 (44%), Gaps = 35/509 (6%)
Query: 67 PPRIVEH-PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSG 125
PP I E P L+V + +L C+A G+P W + G + ++ + SG
Sbjct: 34 PPVITEQSPRRLVVFPTDDISLKCEASGKPEVQFRWTRDGVHFKPKEELGVTVYQSPHSG 93
Query: 126 SLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVGE 185
S F + + ++ +G+Y C A N LG A+SH L ++ V V GE
Sbjct: 94 S-FTITGNNSNFAQRFQGIYRCFASNKLGTAMSHEIRLMAEGAPKWPKETVKPVEVEEGE 152
Query: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITI-RGGKLMITYTRKSDA-GKYVC--- 240
V+ C PP I W +DER+T+ + G L SD Y+C
Sbjct: 153 SVVLPCNPPPSAEPLRIYWMNSKILHIKQDERVTMGQNGNLYFANVLTSDNHSDYICHAH 212
Query: 241 -VGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF----------KCEARGDP 289
GT + ++E +L V S + R L + S+ +C A G P
Sbjct: 213 FPGTRTIIQKEP--IDLRVKATNSMIDRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFP 270
Query: 290 VPTVRWRKDDGELPKSRYEIRDDH-TLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ 348
PT++W + G +P R ++ + TL++ KV D G Y C+AEN +G A + +TV+
Sbjct: 271 TPTIKWLRPSGPMPADRVTYQNHNKTLQLLKVGEEDDGEYRCLAENSLGSARHAYYVTVE 330
Query: 349 EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
P+++ KP+ + G T C+ G PQP + WR G + ++ +
Sbjct: 331 AAPYWLHKPQSHLYGPGETARLDCQVQGRPQPEVTWRING-----IPVEELAKDQKYRI- 384
Query: 409 QTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT-VA 467
Q G L ++NVQ SD C+ N G ++ AY+ V + P ++ NQT +A
Sbjct: 385 QRGALILSNVQPSDTMVTQCEARNRHGLLLANAYIYVVQL----PAKILTAD--NQTYMA 438
Query: 468 VDG-TFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCI 526
V G T L C A G+PVP++ W + QD R NG L IR + DTGRY C+
Sbjct: 439 VQGSTAYLLCKAFGAPVPSVQWLDEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCL 498
Query: 527 ASTPSGEATWSAYIEVQEFGVPVQPPRPT 555
A+ T A ++V++ Q PR T
Sbjct: 499 AANDQNNVTIMANLKVKDATQITQGPRST 527
Score = 174 bits (441), Expect = 6e-43
Identities = 201/825 (24%), Positives = 338/825 (40%), Gaps = 87/825 (10%)
Query: 65 DFPPRIV---EHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRML 121
D PR++ S L+ +G+P L C AEG PTPTI+W + + D+ ++H
Sbjct: 237 DRKPRLLFPTNSSSHLVALQGQPLVLECIAEGFPTPTIKWLRPSGPMPADRVTYQNHNKT 296
Query: 122 LPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAV-SHNASLEVAILRDDFRQNPSDVM 180
L L++ D+G Y C+A N LG A ++ ++E A + P +
Sbjct: 297 LQ-----LLKV-----GEEDDGEYRCLAENSLGSARHAYYVTVEAAPY---WLHKPQSHL 343
Query: 181 VAVGEPAVMECQPPRGHPEPTISWKKDGSPLDD--KDERITIRGGKLMITYTRKSDAGKY 238
GE A ++CQ +G P+P ++W+ +G P+++ KD++ I+ G L+++ + SD
Sbjct: 344 YGPGETARLDCQV-QGRPQPEVTWRINGIPVEELAKDQKYRIQRGALILSNVQPSDTMVT 402
Query: 239 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV--DDSAEFKCEARGDPVPTVRWR 296
C N G + A + V++ P+ + N +A C+A G PVP+V+W
Sbjct: 403 QCEARNRHGLLLAN-AYIYVVQLPAKILTADNQTYMAVQGSTAYLLCKAFGAPVPSVQWL 461
Query: 297 KDDGE--LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354
+DG L R+ + TL IR + A D G Y C+A N A L V++
Sbjct: 462 DEDGTTVLQDERFFPYANGTLGIRDLQANDTGRYFCLAANDQNNVTIMANLKVKDATQIT 521
Query: 355 VKPRDQVVALGRTVTFQCEATGNP--QPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGD 412
PR + G VTF C+A+ +P QP+I WR +G Q S ++ + + G
Sbjct: 522 QGPRSTIEKKGSRVTFTCQASFDPSLQPSITWRGDGRD-----LQELGDSDKYFI-EDGR 575
Query: 413 LTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTF 472
L I ++ SD G Y C + ++A L V V GPV + V D
Sbjct: 576 LVIHSLDYSDQGNYSCVASTELDVVESRAQLLV----------VGSPGPVPRLVLSDLHL 625
Query: 473 VLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQ-IRYAKLGDTGRYTCIASTPS 531
+ S P + D + E + K+ T + +P
Sbjct: 626 LTQSQVRVSWSPA---EDHNAPIEKYDIEFEDKEMAPEKWYSLGKVPGNQTSTTLKLSPY 682
Query: 532 GEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVS-----RNTVTLSWQPN-- 584
T+ + ++G P +P ++ + P A + DV + ++W+P
Sbjct: 683 VHYTFRV-TAINKYG-PGEPSPVSETVVTPEAAPEKNPVDVKGEGNETTNMVITWKPLRW 740
Query: 585 LNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 644
++ A Y ++ + WQ + V + Y V+A N+ G
Sbjct: 741 MDWNAPQVQYRVQWRPQGTRGPWQE--QIVSDPFLVVSNTSTFVPYEIKVQAVNSQGKGP 798
Query: 645 PSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWT---VDQQS 701
Q++ G D+ Q A+ L +L+SS++ V W + Q
Sbjct: 799 EPQVTIGYS---------GEDYPQ-------AIPELEGIEILNSSAVLVKWRPVDLAQVK 842
Query: 702 QYIQGYKILYRPSGANHGESDWLVFE--VRTPAKN-SVVIPDLRKGVNYEIKARPFFNEF 758
+++GY + Y G+ S + + V PA SV++ LR +Y ++ + F
Sbjct: 843 GHLRGYNVTYWREGSQRKHSKRHIHKDHVVVPANTTSVILSGLRPYSSYHLEVQAFNGRG 902
Query: 759 QGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNGMVQEYKVW 816
G SE F+ T E P P + + T++L+ WQPP G V Y
Sbjct: 903 SGPASEFTFS-TPEGVPGHPE---ALHLECQSNTSLLLRWQPPLSHNGVLTGYVLSYHPL 958
Query: 817 CLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 861
G + + N D + + L P +RY ++ A+T G G
Sbjct: 959 DEGGKGQLSFNLR-DPELRTHNLTDLSPHLRYRFQLQATTKEGPG 1002
>gi|119220552 sidekick 1 [Homo sapiens]
Length = 2213
Score = 203 bits (516), Expect = 1e-51
Identities = 213/822 (25%), Positives = 326/822 (39%), Gaps = 89/822 (10%)
Query: 79 VSKGEPATLNC-KAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRK 137
VS+G A LN P P + W++ G ++ P + + L L
Sbjct: 202 VSQGRAAILNLLPITSYPRPQVTWFREGHKII-----PSNRIAITLENQLVILAT----- 251
Query: 138 SRPDEGVYVCVARNYLGEAVSHNASLEVAILRD---DFRQNPSDVM-------VAVGEPA 187
+ D G Y A N + + ++I RD P+ V+ VA
Sbjct: 252 TTSDAGAYYVQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSET 311
Query: 188 VMEC-QPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT--N 244
+EC R + +++WK++G + G +L I+ +D G YVC
Sbjct: 312 TLECIASARPVEDLSVTWKRNGVRITSGLHSF---GRRLTISNPTSADTGPYVCEAALPG 368
Query: 245 MVGERESEVAELTVLERPSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDD---G 300
E A L ++E P F P S ++ V+++ + C+A G P+PT++W KD
Sbjct: 369 SAFEPARATAFLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAISIS 428
Query: 301 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE-PPHFVVKPRD 359
L RY++ L+I+K+ D G + C A N G+ + L V P F +P D
Sbjct: 429 RLQNPRYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIAPVFTQRPVD 488
Query: 360 QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQ 419
V G T +CE +G P+PAI W+RE S + P RF + ++G L I V
Sbjct: 489 TTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIP----RFMLLESGGLQIAPVF 544
Query: 420 RSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVAT 479
D G Y C N GS+ A L V + + PP + V T L C AT
Sbjct: 545 IQDAGNYTCYAANTEGSLNASATLTVWNRTSIVHPPE------DHVVIKGTTATLHCGAT 598
Query: 480 GSPVPTI--LWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 536
P ++ +W+KD V L + SRI ++G L I GD G Y+C + G +
Sbjct: 599 HDPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQTWSGDIGDYSCEIVSEGGNDSR 658
Query: 537 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYII 596
A +EV E P P + +P+ + V LSW + + YI+
Sbjct: 659 MARLEVIEL--------PHSPQNLLVSPNSSH-----SHAVVLSWVRPFDGNSPILYYIV 705
Query: 597 EAFSHASGSSWQTVAENVKTETSAI--KGLKPNAIYLFLVRAANAYGISDPSQISDPVKT 654
E + S W+ NV E + + GL P Y F V A N G S + +
Sbjct: 706 ELSEN--NSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEVGRGQYSAETSRLML 763
Query: 655 QDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY---IQGYKILY 711
+ P++ + R ++ SI V W ++++ ++GY + Y
Sbjct: 764 PEEPPSAPPKNIVASGR---------------TNQSIMVQWQPPPETEHNGVLRGYILRY 808
Query: 712 RPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTL 771
R +G ++ + +P N ++ DL YEI+ + G S TL
Sbjct: 809 RLAGL---PGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSRAVTEYTL 865
Query: 772 EEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD 831
+ P+APPQ V N T I W PPP+ NG+ Q YK+ + +
Sbjct: 866 QGVPTAPPQNVQTEAV--NSTTIQFLWNPPPQQFINGINQGYKLLAWPADAPEAVTVVTI 923
Query: 832 GSTFSVV----IPFLVPGIRYSVEVAASTGAGSGVKSEPQFI 869
F V I L Y V T G G S PQ +
Sbjct: 924 APDFHGVHHGHITNLKKFTAYFTSVLCFTTPGDGPPSTPQLV 965
Score = 196 bits (499), Expect = 1e-49
Identities = 209/850 (24%), Positives = 330/850 (38%), Gaps = 96/850 (11%)
Query: 61 LRQEDFPPRIVEHPS-DLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHR 119
L Q+D P P I +G L C AEG +W + + T + ++
Sbjct: 97 LAQDDVAPYFKTEPGLPQIHLEGNRLVLTCLAEGSWPLEFKWMRDDSELTTYSSE---YK 153
Query: 120 MLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDV 179
++PS + D G Y CV RN +G + + ++VA + F
Sbjct: 154 YIIPS------------LQKLDAGFYRCVVRNRMGALLQRKSEVQVAYM-GSFMDTDQRK 200
Query: 180 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYV 239
V+ G A++ P +P P ++W ++G + + +L+I T SDAG Y
Sbjct: 201 TVSQGRAAILNLLPITSYPRPQVTWFREGHKIIPSNRIAITLENQLVILATTTSDAGAYY 260
Query: 240 CVGTNMVG--ERESEVAELTVLE--------RPSFVKRPSNLAVTVDDS-AEFKCEARGD 288
N + S L++ P+ V P N +V S +C A
Sbjct: 261 VQAVNEKNGENKTSPFIHLSIARDVGTPETMAPTIVVPPGNRSVVAGSSETTLECIASAR 320
Query: 289 PVP--TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAE---NMVGKAEASA 343
PV +V W+++ + + L I T+ D G Y C A + A A+A
Sbjct: 321 PVEDLSVTWKRNGVRITSGLHSF--GRRLTISNPTSADTGPYVCEAALPGSAFEPARATA 378
Query: 344 TLTVQEPPHFVVKPRDQVVA-LGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSS 402
L + EPP+F +P ++ A + TV C+A G P P + W ++ + Q P
Sbjct: 379 FLFIIEPPYFTAEPESRISAEVEETVDIGCQAMGVPLPTLQWYKDAIS--ISRLQNP--- 433
Query: 403 SRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPV 462
R+ V +G L I ++ D G + C N G I T YL+VT++ PV Q PV
Sbjct: 434 -RYKVLASGGLRIQKLRPEDSGIFQCFASNEGGEIQTHTYLDVTNIA-----PVFTQRPV 487
Query: 463 NQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQ---LENGVLQIRYAKLGD 519
+ TV T +L C +G+P P I W+++ ++++ RI + LE+G LQI + D
Sbjct: 488 DTTVTDGMTAILRCEVSGAPKPAITWKRENHILASGSVRIPRFMLLESGGLQIAPVFIQD 547
Query: 520 TGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTL 579
G YTC A+ G SA + V V PP + V
Sbjct: 548 AGNYTCYAANTEGSLNASATLTVWNRTSIVHPPED--------------------HVVIK 587
Query: 580 SWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANA 639
L+ GAT + + W+ +NV L P++ +V +
Sbjct: 588 GTTATLHCGATHDPRVSLRY------VWK--KDNV--------ALTPSSTSRIVVEKDGS 631
Query: 640 YGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQ 699
IS S + S+G + ++ R + H ++S +S H V
Sbjct: 632 LLIS--QTWSGDIGDYSCEIVSEGGNDSRMARLEVIELPHSPQNLLVSPNSSHSHAVVLS 689
Query: 700 QSQYIQGYK-ILYRPSGANHGESDWLVFEVRT-PAKNSVVIPDLRKGVNYEIKARPFFNE 757
+ G ILY + S W V P V + L Y+ +
Sbjct: 690 WVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVCAVNEV 749
Query: 758 FQGA-DSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY--K 814
+G +E EE PSAPP+ + S +I+V WQPPPE NG+++ Y +
Sbjct: 750 GRGQYSAETSRLMLPEEPPSAPPKNIVASGR--TNQSIMVQWQPPPETEHNGVLRGYILR 807
Query: 815 VWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAH 874
G Y ++ L+ +Y ++VAA GAG GV S +
Sbjct: 808 YRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQYEIQVAAYNGAGLGVFSR-AVTEYTLQ 866
Query: 875 GNPVSPEDQV 884
G P +P V
Sbjct: 867 GVPTAPPQNV 876
Score = 93.6 bits (231), Expect = 1e-18
Identities = 95/343 (27%), Positives = 145/343 (42%), Gaps = 47/343 (13%)
Query: 557 PNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSS--WQTVAENV 614
P +P APS ++++S + TL ++P + + + +I+E A G W T+ E
Sbjct: 1066 PPDLPGAPSNLVISNISPRSATLQFRPGYDGKTSISRWIVEGQVGAIGDEEEWVTLYEEE 1125
Query: 615 K---TETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKT----QDVLPTSQGVDHK 667
+ I L P Y F ++ N G S S S ++T DV PTS V
Sbjct: 1126 NEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSSRVIQTLQAPPDVAPTSVTV--- 1182
Query: 668 QVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY-----IQGYKILYRPSGANHGESD 722
S +S+ + W SQY GY+I Y S +S
Sbjct: 1183 ----------------RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDL---QSS 1223
Query: 723 WLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGV 782
+ V + I +L + + YE++ + F G SE+ +T E PSA P+ V
Sbjct: 1224 AVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSEVVRGRTRESVPSAAPENV 1283
Query: 783 TVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC----LGNETRYHINKTVDGSTFSVV 838
S + T IL++W PE QNG++ YK+ L E R HI + T S +
Sbjct: 1284 --SAEAVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIVR--GNHTQSAL 1339
Query: 839 IPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQL---DAHGNPV 878
+ L + Y ++V A T G+GV S P ++ DA G PV
Sbjct: 1340 LAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPPV 1382
Score = 92.8 bits (229), Expect = 2e-18
Identities = 196/884 (22%), Positives = 300/884 (33%), Gaps = 162/884 (18%)
Query: 57 TGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
T + L + P + P D V+ G A L C+ G P P I W K +
Sbjct: 469 THTYLDVTNIAPVFTQRPVDTTVTDGMTAILRCEVSGAPKPAITW-KRENHILASGSVRI 527
Query: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL-RDDFRQN 175
MLL SG L + D G Y C A N G S NAS + + R
Sbjct: 528 PRFMLLESGGLQIAPVF-----IQDAGNYTCYAANTEG---SLNASATLTVWNRTSIVHP 579
Query: 176 PSDVMVAVGEPAVMECQPPRGHPEPTIS----WKKDGSPL-DDKDERITI-RGGKLMITY 229
P D +V G A + C +P +S WKKD L RI + + G L+I+
Sbjct: 580 PEDHVVIKGTTATLHCGATH---DPRVSLRYVWKKDNVALTPSSTSRIVVEKDGSLLISQ 636
Query: 230 TRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDP 289
T D G Y C + G +S +A L V+E P P NL V+ + S
Sbjct: 637 TWSGDIGDYSCEIVS-EGGNDSRMARLEVIELP---HSPQNLLVSPNSSHSH-------- 684
Query: 290 VPTVRW-RKDDGELPKSRYEIRDDHTLKIRKVTAGDMG-----------------SYTCV 331
+ W R DG P Y + KV ++G +
Sbjct: 685 AVVLSWVRPFDGNSPILYYIVELSENNSPWKVHLSNVGPEMTGVTVSGLTPARTYQFRVC 744
Query: 332 AENMVGK----AEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRRE 387
A N VG+ AE S + +EPP P +VA GRT
Sbjct: 745 AVNEVGRGQYSAETSRLMLPEEPPS---APPKNIVASGRT-------------------- 781
Query: 388 GSQNLLFSYQPPQSSSRFSVSQ-----------TGDLTITNVQRSDVGYYICQTL----- 431
+Q+++ +QPP + V + G+ N+ +V Y + L
Sbjct: 782 -NQSIMVQWQPPPETEHNGVLRGYILRYRLAGLPGEYQQRNITSPEVNYCLVTDLIIWTQ 840
Query: 432 --------NVAG-SIITKAYLEVT-DVIADRPPPVIRQGPVNQTVA-----VDGTFVLSC 476
N AG + ++A E T + PP ++ VN T ++
Sbjct: 841 YEIQVAAYNGAGLGVFSRAVTEYTLQGVPTAPPQNVQTEAVNSTTIQFLWNPPPQQFING 900
Query: 477 VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATW 536
+ G + + W D T + + + + + + ++T
Sbjct: 901 INQGYKL--LAWPADAPEAVT----VVTIAPDFHGVHHGHITNLKKFT------------ 942
Query: 537 SAYIEVQEFGVPVQPPRPTDPNLIPSAPSKP------EVTDVSRNTVTLSWQPNLNSGAT 590
+ + V F P P P+ P L+ + KP T++ ++ +SWQ L
Sbjct: 943 AYFTSVLCFTTPGDGP-PSTPQLVWTQEDKPGAVGHLSFTEILDTSLKVSWQEPLEKNGI 1001
Query: 591 PTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISD 650
T Y I + S T N T I+GL Y V A A G ++
Sbjct: 1002 ITGYQISWEVYGRNDSRLTHTLNSTTHEYKIQGLSSLTTYTIDVAAVTAVG---TGLVTS 1058
Query: 651 PVKTQDVLPTSQGVDHKQVQRELG--NAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQGYK 708
+ V P G V + +A L P +SI W V+ Q
Sbjct: 1059 STISSGVPPDLPGAPSNLVISNISPRSATLQF-RPGYDGKTSIS-RWIVEGQ-------- 1108
Query: 709 ILYRPSGANHGESDWLVF--EVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADS-EI 765
GA E +W+ E P + IP+L +Y + + S
Sbjct: 1109 -----VGAIGDEEEWVTLYEEENEPDAQMLEIPNLTPYTHYRFRMKQVNIVGPSPYSPSS 1163
Query: 766 KFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQ----EYKVWCLGNE 821
+ +TL+ P P VTV + T++ + W P P+ NG + K W +
Sbjct: 1164 RVIQTLQAPPDVAPTSVTV--RTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQ 1221
Query: 822 TRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSE 865
+ D I L + Y +++ A G+G SE
Sbjct: 1222 SSAVAQVVSDRLEREFTIEELEEWMEYELQMQAFNAVGAGPWSE 1265
Score = 75.9 bits (185), Expect = 3e-13
Identities = 86/342 (25%), Positives = 139/342 (40%), Gaps = 51/342 (14%)
Query: 552 PRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVA 611
P P L+P A +V+ ++ L W P + GA+P Y WQT +
Sbjct: 1477 PAPPRELLVPQA-------EVTARSLRLQWVPG-SDGASPIRYFTMQVRELPRGEWQTYS 1528
Query: 612 ENVKTETSA--IKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 669
++ E +A + L+P Y ++A N G SD S ++ V T +P
Sbjct: 1529 SSISHEATACVVDRLRPFTSYKLRLKATNDIGDSDFSSETEAVTTLQDVPG--------- 1579
Query: 670 QRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQY---IQGYKILYRP------SG----- 715
E +V + T ++SS+ + W + +QGY+I YR SG
Sbjct: 1580 --EPPGSV----SATPHTTSSVLIQWQPPRDESLNGLLQGYRIYYRELEYEAGSGTEAKT 1633
Query: 716 -----ANHGE-SDWLVFEVRTPAKNSVV--IPDLRKGVNYEIKARPFFNEFQGADSEIKF 767
A H E + F+ + S + + L+K YE+ + + S
Sbjct: 1634 LKNPIALHAELTAQSSFKTVNSSSTSTMCELTHLKKYRRYEVIMTAYNIIGESPASAPVE 1693
Query: 768 AKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGNETRYH 825
E AP+ PQ V V+ + + V+W PPP ++QNG +Q YK+ W ++
Sbjct: 1694 VFVGEAAPAMAPQNVQVTPL--TASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETE 1751
Query: 826 INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQ 867
K + V + L +Y V ++A AG G KS+PQ
Sbjct: 1752 KMKVLFLPEPVVRLKNLTSHTKYLVSISAFNAAGDGPKSDPQ 1793
Score = 57.4 bits (137), Expect = 1e-07
Identities = 84/332 (25%), Positives = 138/332 (41%), Gaps = 37/332 (11%)
Query: 563 APSKPEVTDVSRNTVTLSWQP----NLNSGATPTSYIIEAFSHASGSSW--QTVAENVKT 616
AP+ V S ++ L W P N Y I+ + SS Q V++ ++
Sbjct: 1176 APTSVTVRTASETSLRLRWVPLPDSQYNGNPESVGYRIKYWRSDLQSSAVAQVVSDRLER 1235
Query: 617 ETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNA 676
E + I+ L+ Y ++A NA G S++ +T++ +P++ + V E
Sbjct: 1236 EFT-IEELEEWMEYELQMQAFNAVGAGPWSEVVRG-RTRESVPSAAP---ENVSAE---- 1286
Query: 677 VLHLHNPTVLSSSSIEVHWT-VDQQSQ--YIQGYKILYRPSGANHGESDWLVFEVRTPAK 733
+SS+ I + WT V +Q Q I GYKIL+R + +V R
Sbjct: 1287 --------AVSSTQILLTWTSVPEQDQNGLILGYKILFRAKDLDPEPRSHIV---RGNHT 1335
Query: 734 NSVVIPDLRKGVNYEIKARPFFNEFQGADSE-IKFAKTLEEAPSAPPQGVTVSKNDGNGT 792
S ++ LRK V YE++ F G S + +T ++AP P V + + T
Sbjct: 1336 QSALLAGLRKFVLYELQVLAFTRIGNGVPSTPLILERTKDDAPGPP---VRLVFPEVRLT 1392
Query: 793 AILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVD-GSTF-SVVIPFLVPGIRYSV 850
++ + WQPP E NG++ Y++ + H TV+ G+T L P Y
Sbjct: 1393 SVRIVWQPPEE--PNGIILGYQIAYRLASSSPHTFTTVEVGATVRQFTATDLAPESAYIF 1450
Query: 851 EVAASTGAGSGVKSEPQFIQLDAHGNPVSPED 882
++A T G G E I + P P +
Sbjct: 1451 RLSAKTRQGWGEPLEATVITTEKRERPAPPRE 1482
Score = 47.8 bits (112), Expect = 9e-05
Identities = 88/403 (21%), Positives = 152/403 (37%), Gaps = 54/403 (13%)
Query: 563 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENV---KTETS 619
AP +VT ++ + + ++W P + + + S +T V
Sbjct: 1704 APQNVQVTPLTASQLEVTWDPPPPESQNGNIQGYKIYYWEADSQNETEKMKVLFLPEPVV 1763
Query: 620 AIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLH 679
+K L + YL + A NA G S DP QG H+
Sbjct: 1764 RLKNLTSHTKYLVSISAFNAAGDGPKS---DP---------QQGRTHQAAPGAPSFLAF- 1810
Query: 680 LHNPTVLSSSSIEVHWTVDQQSQYI-QGYKILYRPSGANHGESDWLVFEVRTPAKNSVVI 738
+ ++S+++ V W + I QGY+++Y P G S + EVR + + +
Sbjct: 1811 ----SEITSTTLNVSWGEPAAANGILQGYRVVYEPLAPVQGVSKVVTVEVRGNWQRWLKV 1866
Query: 739 PDLRKGVNY--EIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILV 796
DL KGV Y ++AR G + + E P+ V V+K + + + +
Sbjct: 1867 RDLTKGVTYFFRVQARTI---TYGPELQANITAGPAEGSPGSPRDVLVTK---SASELTL 1920
Query: 797 SWQP--PPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAA 854
W + G V E + G + + +++++ + L G+ Y V A
Sbjct: 1921 QWTEGHSGDTPTTGYVIEARPSDEGLWDMFVKDIPRSATSYTLSLDKLRQGVTYEFRVVA 1980
Query: 855 STGAGSGVKSEPQFIQLDAHGNPVSPEDQVSLAQQISDVVKQPAF--IAGIGAACWIILM 912
AG +G P +P VS AQ + ++ F + + + I+L+
Sbjct: 1981 VNEAG--------------YGEPSNPSTAVS-AQVEAPFYEEWWFLLVMALSSLIVILLV 2025
Query: 913 VFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEA 955
VF++ L+ KK ST GI T +VT GG A
Sbjct: 2026 VFALVLHGQNKKYKN-CSTGKGIS-----TMEESVTLDNGGFA 2062
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 202 bits (515), Expect = 2e-51
Identities = 217/845 (25%), Positives = 345/845 (40%), Gaps = 87/845 (10%)
Query: 68 PRIVEHPSDLIV---SKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPS 124
P ++ PS+ I S+ + TL+C+A G P+P W G +D D HR L
Sbjct: 26 PVFIKEPSNSIFPVGSEDKKITLHCEARGNPSPHYRWQLNG----SDIDMSMEHRYKLNG 81
Query: 125 GSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAVG 184
G+L +V D G Y C A N LG VS A L+ A L + + S V V G
Sbjct: 82 GNL----VVINPNRNWDTGTYQCFATNSLGTIVSREAKLQFAYLENFKTKMRSTVSVREG 137
Query: 185 EPAVMECQPPRGHPEPTISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVCV 241
+ V+ C PP E + +W + P +D ++ G L I+ SD G Y CV
Sbjct: 138 QGVVLLCGPPPHSGELSYAWIFNEYPSFVEEDSRRFVSQETGHLYISKVEPSDVGNYTCV 197
Query: 242 GTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPVP 291
T+MV + ++ R V+ P L + + +C A G+P+P
Sbjct: 198 VTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLECFALGNPIP 257
Query: 292 TVRWRKDDGELPKSRYEIRD-DHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP 350
+ WR+ DG S+ ++R L+I D GSY C+AEN GK A LT
Sbjct: 258 QINWRRSDGLPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRGKNVARGRLTYYAK 317
Query: 351 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
PH+V +D +A+ ++ ++C A+G P+P+ W + G+ +L R + +
Sbjct: 318 PHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVL--------EERTQI-EN 368
Query: 411 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD- 469
G LTI+N+ +D G + C N G + + A L+V P + P+ + V V
Sbjct: 369 GALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVV-----ASAPDFSKNPMKKLVQVQV 423
Query: 470 GTFV-LSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 528
G+ V L C SP W+K V V + RI L +G L+I D G YTC+A
Sbjct: 424 GSLVSLDCKPRASPRALSSWKKGDVSVQ-EHERISLLNDGGLKIANVTKADAGTYTCMAE 482
Query: 529 TPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSG 588
G+A + ++ V T+P I APS +V+ + Q +
Sbjct: 483 NQFGKANGTTHLVV------------TEPTRITLAPSNMDVSVGESVILPCQVQHDPLLD 530
Query: 589 ATPTSYIIEAFS--HASGSSWQTVAENVKTETSAIK-GLKPNAIYLFLVRAANAYGISDP 645
T Y A + GS ++ V + + LK + Y+ +V+ G+
Sbjct: 531 IIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQT----GVDSV 586
Query: 646 SQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQ 705
S +D ++ S G E+ + L + S + +++ ++ +
Sbjct: 587 SSAADL-----IVRGSPGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSV 641
Query: 706 GYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEI 765
G++ + V EV ++ + +L V YE + N+ G + +
Sbjct: 642 GWQTV------------TTVPEVIDGKTHTATVVELNPWVEYEFRV-VASNKIGGGEPSL 688
Query: 766 KFAK--TLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC--LGNE 821
K T E P PP V+ G+ + ++++W P PE+ QNG Y V LG
Sbjct: 689 PSEKVRTEEAVPEVPPS--EVNGGGGSRSELVITWDPVPEELQNGEGFGYVVAFRPLGVT 746
Query: 822 TRYH-INKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSP 880
T + + D + +VP Y V+V G G S P A P
Sbjct: 747 TWIQTVVTSPDTPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFS-PVTTVFSAEEEPTVA 805
Query: 881 EDQVS 885
QVS
Sbjct: 806 PSQVS 810
Score = 201 bits (511), Expect = 5e-51
Identities = 199/761 (26%), Positives = 317/761 (41%), Gaps = 102/761 (13%)
Query: 141 DEGVYVCVARNYLGEAVSHNASLEVAILRDDFR---------QNPSDVMVAVGEPAVMEC 191
D G Y CV + + A + + + D Q P + A G +EC
Sbjct: 190 DVGNYTCVVTSMVTNARVLGSPTPLVLRSDGVMGEYEPKIEVQFPETLPAAKGSTVKLEC 249
Query: 192 QPPRGHPEPTISWKK-DGSPLDDKDERITIR--GGKLMITYTRKSDAGKYVCVGTNMVGE 248
G+P P I+W++ DG P K I +R G L I ++ DAG Y C+ N G+
Sbjct: 250 FA-LGNPIPQINWRRSDGLPFSSK---IKLRKFSGVLEIPNFQQEDAGSYECIAENSRGK 305
Query: 249 RESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYE 308
+ LT +P +V+ ++ + V+DS ++C A G P P+ RW K+ L
Sbjct: 306 NVAR-GRLTYYAKPHWVQLIKDVEIAVEDSLYWECRASGKPKPSYRWLKNGAALVLEERT 364
Query: 309 IRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL-TVQEPPHFVVKPRDQVVAL--G 365
++ L I ++ D G + C+AEN G +SA L V P F P ++V + G
Sbjct: 365 QIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQVQVG 424
Query: 366 RTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGY 425
V+ C+ +P+ W++ G ++ Q R S+ G L I NV ++D G
Sbjct: 425 SLVSLDCKPRASPRALSSWKK-GDVSV-------QEHERISLLNDGGLKIANVTKADAGT 476
Query: 426 YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPT 485
Y C N G +L VT+ P I P N V+V + +L C P+
Sbjct: 477 YTCMAENQFGKANGTTHLVVTE------PTRITLAPSNMDVSVGESVILPCQVQHDPLLD 530
Query: 486 IL--WRKDGVLVSTQDS-----RIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSA 538
I+ W +G L + ++ +G L IR +L +G+Y C+ T + +A
Sbjct: 531 IIFTWYFNGALADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAA 590
Query: 539 YIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEA 598
+ V+ P P +V +++ T LSW+ ++ + SY I+A
Sbjct: 591 DLIVRGS---------------PGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQA 635
Query: 599 FSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVK 653
+ S WQTV + KT T+ + L P Y F V A+N G +PS S+ V+
Sbjct: 636 RTPFS-VGWQTVTTVPEVIDGKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVR 694
Query: 654 TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQ-----GYK 708
T++ +P V +V G S S + + W D + +Q GY
Sbjct: 695 TEEAVPE---VPPSEVNGGGG------------SRSELVITW--DPVPEELQNGEGFGYV 737
Query: 709 ILYRPSGANHGESDWLVFEVRTP------AKNSVVIPDLRKGVNYEIKARPFFNEFQGAD 762
+ +RP G + W+ V +P +N ++P YE+K + N+ +G
Sbjct: 738 VAFRPLGV----TTWIQTVVTSPDTPRYVFRNESIVP----YSPYEVKVGVYNNKGEGPF 789
Query: 763 SEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKV--WCLGN 820
S + + EE P+ P VS N + + I VSW P NG + Y+V W G
Sbjct: 790 SPVTTVFSAEEEPTVAPS--QVSANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGG 847
Query: 821 ETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 861
+ V G+ S + L + Y V A AG+G
Sbjct: 848 KEESSSKMKVAGNETSARLRGLKSNLAYYTAVRAYNSAGAG 888
Score = 171 bits (432), Expect = 7e-42
Identities = 218/874 (24%), Positives = 330/874 (37%), Gaps = 118/874 (13%)
Query: 41 GTPIPTSDNDDNSLGYTGSRLRQEDFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTI 99
G+P P D +G ++ P+I V+ P L +KG L C A G P P I
Sbjct: 209 GSPTPLVLRSDGVMG---------EYEPKIEVQFPETLPAAKGSTVKLECFALGNPIPQI 259
Query: 100 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRP-----DEGVYVCVARNYLG 154
W + LP S LR G P D G Y C+A N G
Sbjct: 260 NWRRSDG---------------LPFSSKIKLRKFSGVLEIPNFQQEDAGSYECIAENSRG 304
Query: 155 EAVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDK 214
+ V+ A + + Q DV +AV + EC+ G P+P+ W K+G+ L
Sbjct: 305 KNVARGRLTYYA--KPHWVQLIKDVEIAVEDSLYWECRAS-GKPKPSYRWLKNGAALV-L 360
Query: 215 DERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSN--LA 272
+ER I G L I+ +D+G + C+ N G S V P F K P +
Sbjct: 361 EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFSKNPMKKLVQ 420
Query: 273 VTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDDHTLKIRKVTAGDMGSYTCV 331
V V C+ R P W+K D + + R + +D LKI VT D G+YTC+
Sbjct: 421 VQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDGGLKIANVTKADAGTYTCM 480
Query: 332 AENMVGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQN 391
AEN GKA + L V EP + P + V++G +V C+ +P I + +
Sbjct: 481 AENQFGKANGTTHLVVTEPTRITLAPSNMDVSVGESVILPCQVQHDPLLDIIFTWYFNGA 540
Query: 392 LLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIAD 451
L + + S +GDL I N+Q G Y+C S+ + A L V +
Sbjct: 541 LADFKKDGSHFEKVGGSSSGDLMIRNIQLKHSGKYVCMVQTGVDSVSSAADLIVRG--SP 598
Query: 452 RPPPVIRQGPVNQTVAV--------DGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIK 503
PP ++ + T A + + V+S ++ W+ + D
Sbjct: 599 GPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVID---- 654
Query: 504 QLENGVLQIRYAKLGDTGRYTCIASTPSGEATW----SAYIEVQEFGVPVQPPRPTDPNL 559
G T T + P E + S I E +P + R T+ +
Sbjct: 655 --------------GKTHTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVR-TEEAV 699
Query: 560 IPSAPSKPEVTDVSRNTVTLSWQP---NLNSGATPTSYIIEAFSHASGSSW-QTVAENVK 615
PS+ SR+ + ++W P L +G Y++ AF ++W QTV +
Sbjct: 700 PEVPPSEVNGGGGSRSELVITWDPVPEELQNG-EGFGYVV-AFRPLGVTTWIQTVVTSPD 757
Query: 616 TETSAIK--GLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQREL 673
T + + P + Y V N G S PV T V QV
Sbjct: 758 TPRYVFRNESIVPYSPYEVKVGVYNNKGEGPFS----PVTTVFSAEEEPTVAPSQV---- 809
Query: 674 GNAVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRT 730
+ LSSS IEV W + ++ GY++ Y G S +
Sbjct: 810 --------SANSLSSSEIEVSWNTIPWKLSNGHLLGYEVRYWNGGGKEESSSKMKV---A 858
Query: 731 PAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGN 790
+ S + L+ + Y R + + G S T + PS PP V + D
Sbjct: 859 GNETSARLRGLKSNLAYYTAVRAYNSAGAGPFSATVNVTTKKTPPSQPPGNVVWNATD-- 916
Query: 791 GTAILVSWQPPPEDTQNGMVQEYKVW----CLGNETRYHINKTVDGSTFSVVIPFLVPGI 846
T +L++W+ V YKV+ N + NKT + +V+P
Sbjct: 917 -TKVLLNWEQVKAMENESEVTGYKVFYRTSSQNNVQVLNTNKT----SAELVLPIKED-- 969
Query: 847 RYSVEVAASTGAGSGVKSE----PQFIQLDAHGN 876
Y +EV A+T G G SE P+ +DA G+
Sbjct: 970 -YIIEVKATTDGGDGTSSEQIRIPRITSMDARGS 1002
>gi|110431348 deleted in colorectal carcinoma [Homo sapiens]
Length = 1447
Score = 200 bits (508), Expect = 1e-50
Identities = 185/721 (25%), Positives = 299/721 (41%), Gaps = 82/721 (11%)
Query: 172 FRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPL----DDKDERITIRGGKLMI 227
F PSD + G +++C P I WKKDG L D++ ++++ G L+I
Sbjct: 42 FLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQLS--NGSLLI 99
Query: 228 -----TYTRKSDAGKYVCVGT-NMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEF 281
+ K D G Y C + G S A++ V F+ + ++ + D+
Sbjct: 100 QNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFMGDTVLL 159
Query: 282 KCEARGDPVPTVRWRKDDGELP----KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 337
KCE G+P+PT+ W+K+ +L SR + L+I ++ GD+G Y C A N
Sbjct: 160 KCEVIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSARNPAS 219
Query: 338 KAEAS-ATLTVQEPP------HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
+ A + + P +F+ +P + V G+ +C +G P P+ W R G +
Sbjct: 220 SRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLR-GEE 278
Query: 391 NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450
+ S ++S+ +L I+NV D G Y C +I A L V
Sbjct: 279 VIQL------RSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVL---- 328
Query: 451 DRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVL 510
PP P N C +G PVPT+ W K+G +V D + + L
Sbjct: 329 --VPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSD-YFQIVGGSNL 385
Query: 511 QIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVT 570
+I D G Y C+A +G A SA + V + +P +++PSAP
Sbjct: 386 RILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIP-------SSSVLPSAPRDVVPV 438
Query: 571 DVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET--SAIKGLKPNA 628
VS V LSW+P + ++ + F G + + + + + LKP A
Sbjct: 439 LVSSRFVRLSWRPPAEAKGNIQTFTV--FFSREGDNRERALNTTQPGSLQLTVGNLKPEA 496
Query: 629 IYLFLVRAANAYGISDPSQISDPVK--TQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVL 686
+Y F V A N +G P + S P+K TQ L V++ Q ++L P
Sbjct: 497 MYTFRVVAYNEWG---PGESSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAY 553
Query: 687 SSSSIEVHWTVDQQSQYIQGYKIL---YRPSGANHGESDWLVFEVRTPAKNSVVIPDLRK 743
++ +QGY++ + E D L ++ + L+K
Sbjct: 554 ANGP-------------VQGYRLFCTEVSTGKEQNIEVDGLSYK----------LEGLKK 590
Query: 744 GVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPE 803
Y ++ + G ++ TL + PSAPPQ V++ N +I VSW PPP
Sbjct: 591 FTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEV--VNSRSIKVSWLPPPS 648
Query: 804 DTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVK 863
TQNG + YK+ TR +T++ + + L G +YS +V+A T G+G
Sbjct: 649 GTQNGFITGYKI-RHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPP 707
Query: 864 S 864
S
Sbjct: 708 S 708
Score = 195 bits (495), Expect = 3e-49
Identities = 214/834 (25%), Positives = 319/834 (38%), Gaps = 108/834 (12%)
Query: 69 RIVEHPSDLIVSKGEPATLNCKAEG-RPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
R + PSD + +G L+C AE R P I+W K G + D+ + L +GSL
Sbjct: 41 RFLSEPSDAVTMRGGNVLLDCSAESDRGVPVIKWKKDGIHLALGMDERKQQ---LSNGSL 97
Query: 128 FFLRIVHGRKSRPDEGVYVCVAR-NYLGEAVSHNASLEVA-ILRDDFRQNPSDVMVAVGE 185
I+H R +PDEG+Y C A G +S A + VA LR F V +G+
Sbjct: 98 LIQNILHSRHHKPDEGLYQCEASLGDSGSIISRTAKVAVAGPLR--FLSQTESVTAFMGD 155
Query: 186 PAVMECQPPRGHPEPTISWKK---DGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVG 242
+++C+ G P PTI W+K D +P+ + + G L I+ + D G Y C
Sbjct: 156 TVLLKCE-VIGEPMPTIHWQKNQQDLTPIPGDSRVVVLPSGALQISRLQPGDIGIYRCSA 214
Query: 243 TNMVGERESEVAELTVLERPS------FVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWR 296
N R AE+ +L P F++RPSN+ A +C G P P+ W
Sbjct: 215 RNPASSRTGNEAEVRILSDPGLHRQLYFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWL 274
Query: 297 KDDG--ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFV 354
+ + +L +Y + L I VT D G YTCV ASA LTV PP F+
Sbjct: 275 RGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFL 334
Query: 355 VKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLT 414
P + + F+C +G P P + W + G + Y F + +L
Sbjct: 335 NHPSNLYAYESMDIEFECTVSGKPVPTVNWMKNGDVVIPSDY--------FQIVGGSNLR 386
Query: 415 ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVL 474
I V +SD G+Y C N AG+ T A L V P P I V + D VL
Sbjct: 387 ILGVVKSDEGFYQCVAENEAGNAQTSAQLIV-------PKPAIPSSSVLPSAPRDVVPVL 439
Query: 475 ------------SCVATGS-PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTG 521
A G+ T+ + ++G ++ + + G LQ+ L
Sbjct: 440 VSSRFVRLSWRPPAEAKGNIQTFTVFFSREG---DNRERALNTTQPGSLQLTVGNLKPEA 496
Query: 522 RYT--CIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL-IPSAPSKPEVTDVSRNTVT 578
YT +A G S I+V T P L +P + S ++
Sbjct: 497 MYTFRVVAYNEWGPGESSQPIKV-----------ATQPELQVPGPVENLQAVSTSPTSIL 545
Query: 579 LSWQPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTE--TSAIKGLKPNAIYLFLVRA 636
++W+P + Y + ++G +N++ + + ++GLK Y A
Sbjct: 546 ITWEPPAYANGPVQGYRLFCTEVSTGKE-----QNIEVDGLSYKLEGLKKFTEYSLRFLA 600
Query: 637 ANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW- 695
N YG P +D + T L + V E V++S SI+V W
Sbjct: 601 YNRYG---PGVSTDDI-TVVTLSDVPSAPPQNVSLE------------VVNSRSIKVSWL 644
Query: 696 --TVDQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARP 753
Q+ +I GYKI +R + GE E P + L KG Y +
Sbjct: 645 PPPSGTQNGFITGYKIRHRKT-TRRGE-----METLEPNNLWYLFTGLEKGSQYSFQVSA 698
Query: 754 FFNEFQGADSEIKFAKTLE---EAPSAPPQGVTVSKNDGNGTAILVSWQPP--PEDTQNG 808
G S A+T E + P Q ++ I++SW PP P G
Sbjct: 699 MTVNGTGPPSNWYTAETPENDLDESQVPDQPSSLHVRP-QTNCIIMSWTPPLNPNIVVRG 757
Query: 809 MVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGV 862
+ Y G + Y VD I L Y + + A AG GV
Sbjct: 758 YIIGY-----GVGSPYAETVRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGV 806
Score = 157 bits (397), Expect = 8e-38
Identities = 227/858 (26%), Positives = 329/858 (38%), Gaps = 124/858 (14%)
Query: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
P R + + G+ L C+ G P PTI W K + + D R ++LPSG+
Sbjct: 139 PLRFLSQTESVTAFMGDTVLLKCEVIGEPMPTIHWQKNQQDLTPIPGDSRV--VVLPSGA 196
Query: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDD-------FRQNPSDV 179
L R+ G D G+Y C ARN + A EV IL D F Q PS+V
Sbjct: 197 LQISRLQPG-----DIGIYRCSARNPASSRTGNEA--EVRILSDPGLHRQLYFLQRPSNV 249
Query: 180 MVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGK-LMITYTRKSDAGKY 238
+ G+ AV+EC G+P P+ +W + + + ++ ++ GG L+I+ D+G Y
Sbjct: 250 VAIEGKDAVLECCVS-GYPPPSFTWLRGEEVIQLRSKKYSLLGGSNLLISNVTDDDSGMY 308
Query: 239 VCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKD 298
CV T E S AELTVL P F+ PSNL EF+C G PVPTV W K+
Sbjct: 309 TCVVTYK-NENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSGKPVPTVNWMKN 367
Query: 299 -DGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP--PHFVV 355
D +P ++I L+I V D G Y CVAEN G A+ SA L V +P P V
Sbjct: 368 GDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQLIVPKPAIPSSSV 427
Query: 356 ---KPRDQVVAL--GRTVTFQ----CEATGNPQP-AIFWRREGSQNLLFSYQPPQSSSRF 405
PRD V L R V EA GN Q +F+ REG
Sbjct: 428 LPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQTFTVFFSREGDNR----------ERAL 477
Query: 406 SVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQ------ 459
+ +Q G L +T Y + + AY E + +P V Q
Sbjct: 478 NTTQPGSLQLTVGNLKPEAMYTFRVV---------AYNEWGPGESSQPIKVATQPELQVP 528
Query: 460 GPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGV-LVSTQDSRIKQLENGVLQIRYAKLG 518
GPV AV T S + T P G L T+ S K+ V + Y KL
Sbjct: 529 GPVENLQAV-STSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSY-KLE 586
Query: 519 DTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNL--IPSA-PSKPEVTDVSRN 575
++T + ++ +G V T L +PSA P + V+
Sbjct: 587 GLKKFTEYS---------LRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSR 637
Query: 576 TVTLSW--QPNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTETSAIKGLKPNAIYLFL 633
++ +SW P+ T Y I +T+ N GL+ + Y F
Sbjct: 638 SIKVSWLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPN--NLWYLFTGLEKGSQYSFQ 695
Query: 634 VRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEV 693
V A G PS ++ L SQ D + LH+ T + I +
Sbjct: 696 VSAMTVNGTGPPSNWYTAETPENDLDESQVPDQP--------SSLHVRPQT----NCIIM 743
Query: 694 HWTVD-QQSQYIQGYKILYRPSGANHGESDWLVFEVRTPAKNSVV-IPDLRKGVNYEIKA 751
WT + ++GY I Y G+ + E+ VR +K I L +Y I
Sbjct: 744 SWTPPLNPNIVVRGYIIGY-GVGSPYAET------VRVDSKQRYYSIERLESSSHYVISL 796
Query: 752 RPFFNEFQGA--------------DSEIKFAKTLEEAPSA---------PPQGVTVSKND 788
+ F N +G + + L++ P++ PP GV
Sbjct: 797 KAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSVPDLSTPMLPPVGVQAVALT 856
Query: 789 GNGTAILVSW--QPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIPFLVPGI 846
+ A+ VSW P++ + V+ Y V + + K+ D ++ S L P
Sbjct: 857 HD--AVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNT 914
Query: 847 RYSVEVAASTGAGSGVKS 864
Y V + S S
Sbjct: 915 MYEFSVMVTKNRRSSTWS 932
Score = 74.3 bits (181), Expect = 9e-13
Identities = 77/334 (23%), Positives = 136/334 (40%), Gaps = 31/334 (9%)
Query: 551 PPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSW-QT 609
P D + +P PS V + N + +SW P LN YII + GS + +T
Sbjct: 716 PENDLDESQVPDQPSSLHVRPQT-NCIIMSWTPPLNPNIVVRGYII---GYGVGSPYAET 771
Query: 610 VAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQV 669
V + K +I+ L+ ++ Y+ ++A N G P + + T+ + + VD+ +
Sbjct: 772 VRVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVP--LYESATTRSITDPTDPVDYYPL 829
Query: 670 QRELGNAVLHLHNPTV---------LSSSSIEVHWT-----VDQQSQYIQGYKILYRPSG 715
+ +V L P + L+ ++ V W +Q++ ++ Y + +R S
Sbjct: 830 LDDFPTSVPDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSF 889
Query: 716 ANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAP 775
+ + ++ S L+ YE N S A T E AP
Sbjct: 890 SASAK-----YKSEDTTSLSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAP 944
Query: 776 SAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNET---RYHINKTVDG 832
++ P+ +TV +G A++VSWQPP E NG + Y ++ ++ I +T+ G
Sbjct: 945 TSAPKDLTVITREGKPRAVIVSWQPPLE--ANGKITAYILFYTLDKNIPIDDWIMETISG 1002
Query: 833 STFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 866
+ I L Y + A G G S+P
Sbjct: 1003 DRLTHQIMDLNLDTMYYFRIQARNSKGVGPLSDP 1036
>gi|7657361 contactin 6 [Homo sapiens]
Length = 1028
Score = 194 bits (492), Expect = 8e-49
Identities = 206/819 (25%), Positives = 321/819 (39%), Gaps = 82/819 (10%)
Query: 68 PRIVEHPSDLI----VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 123
P + P D+I +SK E LNC A G P+P W + G TD D S+ L
Sbjct: 26 PIFTQEPHDVIFPLDLSKSE-VILNCAANGYPSPHYRWKQNG----TDIDFTMSYHYRLD 80
Query: 124 SGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMVAV 183
GSL ++ + D G+Y C+A N LG +S A L+ A + D + S V V
Sbjct: 81 GGSL----AINSPHTDQDIGMYQCLATNLLGTILSRKAKLQFAYIEDFETKTRSTVSVRE 136
Query: 184 GEPAVMECQPPRGHPEPTISWKKDGSPL---DDKDERITIRGGKLMITYTRKSDAGKYVC 240
G+ V+ C PP + + +W + +PL +D ++ G L I SD G Y C
Sbjct: 137 GQGVVLLCGPPPHFGDLSYAWTFNDNPLYVQEDNRRFVSQETGNLYIAKVEPSDVGNYTC 196
Query: 241 VGTNMVGERESEVAELTVLERPS----------FVKRPSNLAVTVDDSAEFKCEARGDPV 290
TN +R + +++R V+ P + D S + +C A G+PV
Sbjct: 197 FITNKEAQRSVQGPPTPLVQRTDGVMGEYEPKIEVRFPETIQAAKDSSVKLECFALGNPV 256
Query: 291 PTVRWRKDDGE-LPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 349
P + WR+ DG LP + L+I D G Y C+A N+ G+ A L
Sbjct: 257 PDISWRRLDGSPLPGKVKYSKSQAILEIPNFQQEDEGFYECIASNLRGRNLAKGQLIFYA 316
Query: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 409
PP + K ++ +++ + ++C+A+G P P W + G + R + +
Sbjct: 317 PPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYTWLKNGER--------LNPEERIQI-E 367
Query: 410 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQT--VA 467
G L IT + SD G Y C N I A L V P + PV + V
Sbjct: 368 NGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVL-----ASAPDFSKSPVKKKSFVQ 422
Query: 468 VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 527
V G V+ C P I W++ G Q RI LE+G L+I D G YTCIA
Sbjct: 423 VGGDIVIGCKPNAFPRAAISWKR-GTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIA 481
Query: 528 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQPNLNS 587
+ G A + + V+E V PP D + S +V+ V W N
Sbjct: 482 TNQFGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVW--FFNG 539
Query: 588 GATPTSYIIEAFSHASGSS-WQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPS 646
+ F G S + N++ S K L L + A + P
Sbjct: 540 DVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSG-KYLCTVQTTLESLSAVADIIVRGPP 598
Query: 647 QISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHWTVDQQSQYIQG 706
+ V+ +D+ T+ + + N+ + + T+ + + V W I
Sbjct: 599 GPPEDVQVEDISSTTSQLSWRAGPD--NNSPIQIF--TIQTRTPFSVGWQAVATVPEILN 654
Query: 707 YKILYRPSGANHGESDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSE-I 765
K + G S W+ +E R A NS+ I G SE
Sbjct: 655 GKTY---NATVVGLSPWVEYEFRVVAGNSIGI---------------------GEPSEPS 690
Query: 766 KFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWC--LGNET- 822
+ +T P P V + G+ + ++++W+ PE+ QNG Y + +G+ T
Sbjct: 691 ELLRTKASVPVVAP--VNIHGGGGSRSELVITWESIPEELQNGEGFGYIIMFRPVGSTTW 748
Query: 823 RYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSG 861
+V+ S F ++P + V+V G G
Sbjct: 749 SKEKVSSVESSRFVYRNESIIPLSPFEVKVGVYNNEGEG 787
Score = 176 bits (445), Expect = 2e-43
Identities = 191/715 (26%), Positives = 305/715 (42%), Gaps = 79/715 (11%)
Query: 176 PSDVMVAVGEPAVMECQPPRGHPEPTISWKK-DGSPLDDKDERITIRGGKLMITYTRKSD 234
P + A +EC G+P P ISW++ DGSPL K + + L I ++ D
Sbjct: 234 PETIQAAKDSSVKLECFA-LGNPVPDISWRRLDGSPLPGK-VKYSKSQAILEIPNFQQED 291
Query: 235 AGKYVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVR 294
G Y C+ +N+ G R +L P + ++ N +++ D+ ++C+A G P P
Sbjct: 292 EGFYECIASNLRG-RNLAKGQLIFYAPPEWEQKIQNTHLSIYDNLLWECKASGKPNPWYT 350
Query: 295 WRKDDGEL-PKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV-QEPPH 352
W K+ L P+ R +I ++ TL I + D G Y C AEN A+A L V P
Sbjct: 351 WLKNGERLNPEERIQI-ENGTLIITMLNVSDSGVYQCAAENKYQIIYANAELRVLASAPD 409
Query: 353 FVVKP--RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
F P + V +G + C+ P+ AI W+R G++ L + S R + +
Sbjct: 410 FSKSPVKKKSFVQVGGDIVIGCKPNAFPRAAISWKR-GTETL-------RQSKRIFLLED 461
Query: 411 GDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDG 470
G L I N+ RSD G Y C N G+ L ++ +R VI P V V
Sbjct: 462 GSLKIYNITRSDAGSYTCIATNQFGTAKNTGSL----IVKERT--VITVPPSKMDVTVGE 515
Query: 471 TFVLSCVATGSPVPTIL--WRKDGVLVSTQDS-----RIKQLENGVLQIRYAKLGDTGRY 523
+ VL C + P ++ W +G ++ + RI G L IR +L +G+Y
Sbjct: 516 SIVLPCQVSHDPSIEVVFVWFFNGDVIDLKKGVAHFERIGGESVGDLMIRNIQLHHSGKY 575
Query: 524 TCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTVTLSWQP 583
C T + A I V+ PP P P +V D+S T LSW+
Sbjct: 576 LCTVQTTLESLSAVADIIVRG------PPGP---------PEDVQVEDISSTTSQLSWRA 620
Query: 584 NLNSGATPTSYIIEAFSHASGSSWQTVAE-----NVKTETSAIKGLKPNAIYLFLVRAAN 638
++ + + I+ + S WQ VA N KT + + GL P Y F V A N
Sbjct: 621 GPDNNSPIQIFTIQTRTPFS-VGWQAVATVPEILNGKTYNATVVGLSPWVEYEFRVVAGN 679
Query: 639 AYGISDPSQISDPVKTQDVLPTSQGVDHKQVQRELGNAVLHLHNPTVLSSSSIEVHW-TV 697
+ GI +PS+ S+ ++T+ +P A +++H S S + + W ++
Sbjct: 680 SIGIGEPSEPSELLRTKASVPVV--------------APVNIHGGGG-SRSELVITWESI 724
Query: 698 DQQSQYIQ--GYKILYRPSGANHGESDWL--VFEVRTPAKNSVVIPDLRKGVNYEIKARP 753
++ Q + GY I++RP G+ + + V R +N +IP +E+K
Sbjct: 725 PEELQNGEGFGYIIMFRPVGSTTWSKEKVSSVESSRFVYRNESIIP----LSPFEVKVGV 780
Query: 754 FFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEY 813
+ NE +G+ S + + E+ P P+G S + + + VSW + G V Y
Sbjct: 781 YNNEGEGSLSTVTIVYSGEDEPQLAPRG--TSLQSFSASEMEVSWNAIAWNRNTGRVLGY 838
Query: 814 KV--WCLGNETRYHINKTVDGSTFSVVIPFLVPGIRYSVEVAASTGAGSGVKSEP 866
+V W ++ V G+ + I L Y V A AG+G S P
Sbjct: 839 EVLYWTDDSKESMIGKIRVSGNVTTKNITGLKANTIYFASVRAYNTAGTGPSSPP 893
Score = 142 bits (359), Expect = 2e-33
Identities = 198/868 (22%), Positives = 332/868 (38%), Gaps = 108/868 (12%)
Query: 41 GTPIPTSDNDDNSLGYTGSRLRQEDFPPRI-VEHPSDLIVSKGEPATLNCKAEGRPTPTI 99
G P P D +G ++ P+I V P + +K L C A G P P I
Sbjct: 209 GPPTPLVQRTDGVMG---------EYEPKIEVRFPETIQAAKDSSVKLECFALGNPVPDI 259
Query: 100 EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH 159
W + D + S S L I + ++ DEG Y C+A N G ++
Sbjct: 260 SWRR--------LDGSPLPGKVKYSKSQAILEIPNFQQE--DEGFYECIASNLRGRNLAK 309
Query: 160 NASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERIT 219
+ A ++ Q + +++ + + EC+ G P P +W K+G L+ +ERI
Sbjct: 310 GQLIFYA--PPEWEQKIQNTHLSIYDNLLWECKAS-GKPNPWYTWLKNGERLNP-EERIQ 365
Query: 220 IRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVL-ERPSFVKRP--SNLAVTVD 276
I G L+IT SD+G Y C N + AEL VL P F K P V V
Sbjct: 366 IENGTLIITMLNVSDSGVYQCAAENKYQIIYAN-AELRVLASAPDFSKSPVKKKSFVQVG 424
Query: 277 DSAEFKCEARGDPVPTVRWRKDDGELPKS-RYEIRDDHTLKIRKVTAGDMGSYTCVAENM 335
C+ P + W++ L +S R + +D +LKI +T D GSYTC+A N
Sbjct: 425 GDIVIGCKPNAFPRAAISWKRGTETLRQSKRIFLLEDGSLKIYNITRSDAGSYTCIATNQ 484
Query: 336 VGKAEASATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFS 395
G A+ + +L V+E V P V +G ++ C+ + +P + + + +++
Sbjct: 485 FGTAKNTGSLIVKERTVITVPPSKMDVTVGESIVLPCQVSHDPSIEVVFVWFFNGDVIDL 544
Query: 396 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP 455
+ R GDL I N+Q G Y+C S+ V D+I PP
Sbjct: 545 KKGVAHFERIGGESVGDLMIRNIQLHHSGKYLCTVQTTLESLSA-----VADIIVRGPP- 598
Query: 456 VIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWR-----KDGVLVSTQDSR--IKQLENG 508
GP D S + WR + + T +R
Sbjct: 599 ----GPPEDVQVED---------ISSTTSQLSWRAGPDNNSPIQIFTIQTRTPFSVGWQA 645
Query: 509 VLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPN-LIPSAPSKP 567
V + G T T + +P W Y G + P++P+ L+ + S P
Sbjct: 646 VATVPEILNGKTYNATVVGLSP-----WVEYEFRVVAGNSIGIGEPSEPSELLRTKASVP 700
Query: 568 EVTDV-------SRNTVTLSWQ--PNLNSGATPTSYIIEAFSHASGSSWQTVAENVKTET 618
V V SR+ + ++W+ P YII F ++W K +
Sbjct: 701 VVAPVNIHGGGGSRSELVITWESIPEELQNGEGFGYII-MFRPVGSTTWS------KEKV 753
Query: 619 SAIKGLKPNAIYLFLVRAANAYGISDPSQISDPV---KTQDVLPTSQGVDHKQVQRELGN 675
S+++ + F+ R + +S P ++ V + + L T V + + +L
Sbjct: 754 SSVESSR------FVYRNESIIPLS-PFEVKVGVYNNEGEGSLSTVTIVYSGEDEPQLAP 806
Query: 676 AVLHLHNPTVLSSSSIEVHWTV---DQQSQYIQGYKILYRPSGANHGESDWLVFEVRTPA 732
L + S+S +EV W ++ + + GY++LY + +
Sbjct: 807 RGTSLQS---FSASEMEVSWNAIAWNRNTGRVLGYEVLYWTDDSKESMIGKIRVSGNVTT 863
Query: 733 KNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQGVTVSKNDGNGT 792
KN I L+ Y R + G S T + PS PP + + +
Sbjct: 864 KN---ITGLKANTIYFASVRAYNTAGTGPSSPPVNVTTKKSPPSQPPANIAWKLTN---S 917
Query: 793 AILVSWQPPPEDTQNGMVQEYKVWCLGN-ETRYHINKTVDGSTFSVVIPFLVPGIRYSVE 851
+ ++W+ V YK+ N +++ HI +T + ++ +++PF Y +E
Sbjct: 918 KLCLNWEHVKTMENESEVLGYKILYRQNRQSKTHILET-NNTSAELLVPFEED---YLIE 973
Query: 852 VAASTGAGSGVKSE----PQFIQLDAHG 875
+ + G G SE P+ L + G
Sbjct: 974 IRTVSDGGDGSSSEEIRIPKMSSLSSRG 1001
>gi|126517478 peroxidasin homolog-like [Homo sapiens]
Length = 1463
Score = 193 bits (490), Expect = 1e-48
Identities = 126/373 (33%), Positives = 185/373 (49%), Gaps = 21/373 (5%)
Query: 176 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD-DKDERITI-RGGKLMITYTRKS 233
P DV V G C+ G+P+P I W + LD + D R+ + G LMI TR+S
Sbjct: 240 PQDVEVPSGNTVYFTCRA-EGNPKPEIIWIHNNHSLDLEDDTRLNVFDDGTLMIRNTRES 298
Query: 234 DAGKYVCVGTNMVGERESEVAEL---TVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPV 290
D G Y C+ N GE +++ A L ++ +PSFV +P + V + S +C A G P
Sbjct: 299 DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGTSTTLECMATGHPH 358
Query: 291 PTVRWRKDDG-ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE 349
P + W +D+G EL SR+ + L ++ +T D G +TC A N G +A+A + VQ
Sbjct: 359 PLITWTRDNGLELDGSRH-VATSSGLYLQNITQRDHGRFTCHANNSHGTVQAAANIIVQA 417
Query: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQ 409
PP F V P+DQVV V + CEA GNP P I W + G Q + + +V
Sbjct: 418 PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPV--------EGQHTVLS 469
Query: 410 TGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 469
+G L I + D G Y CQ ++ G + K +++T + + V Q P + +V V
Sbjct: 470 SGTLRIDRAAQHDQGQYECQAVSSLG--VKKVSVQLT--VKPKALAVFTQLPQDTSVEVG 525
Query: 470 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 529
+SC A G P P I W K+GV + T+ + + G L I A D GRY C+A
Sbjct: 526 KNINISCHAQGEPQPIITWNKEGVQI-TESGKFHVDDEGTLTIYDAGFPDQGRYECVARN 584
Query: 530 PSGEATWSAYIEV 542
G A + ++ V
Sbjct: 585 SFGLAVTNMFLTV 597
Score = 185 bits (469), Expect = 4e-46
Identities = 123/386 (31%), Positives = 179/386 (46%), Gaps = 24/386 (6%)
Query: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
PRI P D+ V G C+AEG P P I W ++ + DD R + + G+L
Sbjct: 234 PRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLE-DDTRLN--VFDDGTL 290
Query: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAIL--RDDFRQNPSDVMVAVGE 185
I + R+S D+GVY C+ARN GEA + +A L + L + F P D V +G
Sbjct: 291 M---IRNTRES--DQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTEVLIGT 345
Query: 186 PAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNM 245
+EC GHP P I+W +D D + G + T++ D G++ C N
Sbjct: 346 STTLECM-ATGHPHPLITWTRDNGLELDGSRHVATSSGLYLQNITQR-DHGRFTCHANNS 403
Query: 246 VGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELP-K 304
G ++ A + V P F P + V + + E+ CEA G+P P + W K G+LP +
Sbjct: 404 HGTVQA-AANIIVQAPPQFTVTPKDQVVLEEHAVEWLCEADGNPPPVIVWTKTGGQLPVE 462
Query: 305 SRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEP--PHFVVKPRDQVV 362
++ + TL+I + D G Y C A + +G + S LTV+ F P+D V
Sbjct: 463 GQHTVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLTVKPKALAVFTQLPQDTSV 522
Query: 363 ALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSD 422
+G+ + C A G PQP I W +EG Q S +F V G LTI + D
Sbjct: 523 EVGKNINISCHAQGEPQPIITWNKEGVQ--------ITESGKFHVDDEGTLTIYDAGFPD 574
Query: 423 VGYYICQTLNVAGSIITKAYLEVTDV 448
G Y C N G +T +L VT +
Sbjct: 575 QGRYECVARNSFGLAVTNMFLTVTAI 600
Score = 128 bits (321), Expect = 5e-29
Identities = 91/318 (28%), Positives = 142/318 (44%), Gaps = 27/318 (8%)
Query: 253 VAELTVLE----RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKS 305
VA +TV E P P ++ V ++ F C A G+P P + W ++ L +
Sbjct: 221 VASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDLEDDT 280
Query: 306 RYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL----TVQEPPHFVVKPRDQV 361
R + DD TL IR D G Y C+A N G+A+ + + ++ P FV++P+D
Sbjct: 281 RLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFVIQPQDTE 340
Query: 362 VALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRS 421
V +G + T +C ATG+P P I W R+ L SR + +G L + N+ +
Sbjct: 341 VLIGTSTTLECMATGHPHPLITWTRDNGLEL--------DGSRHVATSSG-LYLQNITQR 391
Query: 422 DVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGS 481
D G + C N G++ A + V + PP P +Q V + C A G+
Sbjct: 392 DHGRFTCHANNSHGTVQAAANIIV------QAPPQFTVTPKDQVVLEEHAVEWLCEADGN 445
Query: 482 PVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIE 541
P P I+W K G + + L +G L+I A D G+Y C A + G S +
Sbjct: 446 PPPVIVWTKTGGQLPVEGQH-TVLSSGTLRIDRAAQHDQGQYECQAVSSLGVKKVSVQLT 504
Query: 542 VQEFGVPVQPPRPTDPNL 559
V+ + V P D ++
Sbjct: 505 VKPKALAVFTQLPQDTSV 522
Score = 90.9 bits (224), Expect = 9e-18
Identities = 68/207 (32%), Positives = 95/207 (45%), Gaps = 14/207 (6%)
Query: 341 ASATLTVQE----PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSY 396
A A++TV+E P +P+D V G TV F C A GNP+P I W L
Sbjct: 220 AVASVTVEEFNCQSPRITFEPQDVEVPSGNTVYFTCRAEGNPKPEIIWIHNNHSLDL--- 276
Query: 397 QPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPV 456
+ +R +V G L I N + SD G Y C N AG T++ + + +P V
Sbjct: 277 ---EDDTRLNVFDDGTLMIRNTRESDQGVYQCMARNSAGEAKTQSAMLRYSSLPAKPSFV 333
Query: 457 IRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAK 516
I+ P + V + + L C+ATG P P I W +D L SR +G L ++
Sbjct: 334 IQ--PQDTEVLIGTSTTLECMATGHPHPLITWTRDNGL-ELDGSRHVATSSG-LYLQNIT 389
Query: 517 LGDTGRYTCIASTPSGEATWSAYIEVQ 543
D GR+TC A+ G +A I VQ
Sbjct: 390 QRDHGRFTCHANNSHGTVQAAANIIVQ 416
Score = 73.9 bits (180), Expect = 1e-12
Identities = 61/210 (29%), Positives = 95/210 (45%), Gaps = 15/210 (7%)
Query: 39 DHGTPIPTSDNDDNSLGYTGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPT 98
DHG ++N ++ + + Q PP+ P D +V + C+A+G P P
Sbjct: 392 DHGRFTCHANNSHGTVQAAANIIVQA--PPQFTVTPKDQVVLEEHAVEWLCEADGNPPPV 449
Query: 99 IEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG-EAV 157
I W K G ++ + +L SG+ LRI R ++ D+G Y C A + LG + V
Sbjct: 450 IVWTKTGGQLPVE-----GQHTVLSSGT---LRI--DRAAQHDQGQYECQAVSSLGVKKV 499
Query: 158 SHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDER 217
S +++ L F Q P D V VG+ + C +G P+P I+W K+G + + +
Sbjct: 500 SVQLTVKPKALA-VFTQLPQDTSVEVGKNINISCH-AQGEPQPIITWNKEGVQITESGKF 557
Query: 218 ITIRGGKLMITYTRKSDAGKYVCVGTNMVG 247
G L I D G+Y CV N G
Sbjct: 558 HVDDEGTLTIYDAGFPDQGRYECVARNSFG 587
>gi|17511435 roundabout homolog 4, magic roundabout [Homo sapiens]
Length = 1007
Score = 192 bits (489), Expect = 2e-48
Identities = 276/1084 (25%), Positives = 414/1084 (38%), Gaps = 154/1084 (14%)
Query: 449 IADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVST---------QD 499
+A PP I P +Q G +SC A+G P PTI W +G +S D
Sbjct: 26 MAQDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPD 85
Query: 500 SRIKQLE---NGVLQIRYAKLGDTGRYTCIASTPSGEAT-----WSAYIEVQEFGVPVQP 551
+ L+ G A D G YTC AS G A S + ++F +
Sbjct: 86 GTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQI---- 141
Query: 552 PRPTDPNLIPSAPSKPEVTDV-SRNTVTLSWQPNLNSGATPTSYIIEAFSHASGSSWQTV 610
+P D + E T+SW + A ++ H +
Sbjct: 142 -QPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLA------LQPGRHTVSGGSLLM 194
Query: 611 AENVKTETSAIKGLKPNAIYLFLVRAANAYGISDPSQISDPVKTQDVLPTSQGVDHKQVQ 670
A K++ + N+ RAA I +P ++PV
Sbjct: 195 ARAEKSDEGTYMCVATNSAGHRESRAARV-SIQEPQDYTEPV------------------ 235
Query: 671 RELGNAVLHLHNPTVLSSSSIE---------VHWTVDQQSQYIQGYKILYRPSGANHGE- 720
EL + L N T+L+ E + W V + Q Y L+R A G+
Sbjct: 236 -ELLAVRIQLENVTLLNPDPAEGPKPRPAVWLSWKVSGPAAPAQSYTALFRTQTAPGGQG 294
Query: 721 SDWLVFEVRTPAKNSVVIPDLRKGVNYEIKARPFFNEFQGADSEIKFAKTLEEAPSAPPQ 780
+ W E S + L G +YE K RP +G DS + + E+ PSAPPQ
Sbjct: 295 APWA--EELLAGWQSAELGGLHWGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQ 352
Query: 781 GVTVSKNDGNGTAILVSWQPPPEDTQNGMVQEYKVWCLGNETRYHINKTVDGSTFSVVIP 840
VT+ GNGT + VSW PPP + NG+++ Y+VW LGN + N TV G + I
Sbjct: 353 EVTLKP--GNGT-VFVSWVPPPAENHNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLEIA 409
Query: 841 FLVPGIRYSVEVAASTGAGSGVKSEPQFIQLDAHGNPVSPEDQVS---LAQQISDVVKQP 897
+PG Y V+VAA TGAG+G S P + L+ + E +Q+ +K+P
Sbjct: 410 THMPG-SYCVQVAAVTGAGAGEPSRPVCLLLEQAMERATQEPSEHGPWTLEQLRATLKRP 468
Query: 898 AFIAGIGAACWIILMVFSIWLYRHRKKRNGLTSTYAGIRKVPSFTFTPTVTYQRGGEAVS 957
IA G A W++L+ ++ ++R R+ R L P + +A+
Sbjct: 469 EVIATCGVALWLLLLGTAVCIHRRRRARVHL---------------GPGLYRYTSEDAI- 512
Query: 958 SGGRPGLLNISEPAAQPWLADTWPNTGNNHNDCSISCCTAGNGNSDSNLTTYSRPADCIA 1017
L + + + WLADTW +T + D S S + +D+ P DC
Sbjct: 513 ------LKHRMDHSDSQWLADTWRSTSGS-RDLSSSSSLSSRLGADAR-----DPLDCRR 560
Query: 1018 NYNNQLDNKQTNLMLPE-STVYGDVDLSNKINEMKTFNSPNLKDGRFVNP--SGQPTPYA 1074
+ + +LP+ ST YG + ++ + SP + R + P + +P +
Sbjct: 561 SLLSWDSRSPGVPLLPDTSTFYGSL-IAELPSSTPARPSPQVPAVRRLPPQLAQLSSPCS 619
Query: 1075 TTQLIQSNLSNNMNNGSGDSGEKHWKPLGQQKQEVAPVQYNIVEQNKLNKDYRANDTVPP 1134
++ + S + S E WK ++KQE+ + + + + + RA +
Sbjct: 620 SSDSLCSRRGLSSPRLSLAPAEA-WK--AKKKQELQHANSSPLLRGSHSLELRACEL--- 673
Query: 1135 TIPYNQSYDQNTGGSYNSSDRGSSTSGSQGHKKGARTPKVPKQGGMNWADLLPPPP--AH 1192
N G S G+ + A PK+ LPP P H
Sbjct: 674 ---------GNRGSKNLSQSPGAVPQALVAWR--ALGPKLLSSSNELVTRHLPPAPLFPH 722
Query: 1193 PPPHSNSEEYNISVDESYDQEMPCPVPPARMYLQQDELEEEEDERGPTPPVRGAASSPAA 1252
P + S++ V + P P + + P SS +
Sbjct: 723 ETPPTQSQQTQPPVAPQAPSSILLPAAPIPILSPCSPPSPQASSLSGPSPASSRLSSSSL 782
Query: 1253 VSYSHQSTATLTPSPQEELQPMLQDCPEETGHMQHQPDRRRQPVSPPPPPRPISPPHTYG 1312
S + LTP EE+ L+ + + R VS P PR SPP TYG
Sbjct: 783 SSLGEDQDSVLTP---EEVALCLE--------LSEGEETPRNSVS--PMPRAPSPPTTYG 829
Query: 1313 YISGPLVSDMDTDAPEEEEDEADMEVAKMQTRRLLLRGLEQTPASSVGDLESSVTGSMIN 1372
YIS P S+ TD + R L TP S GS+ N
Sbjct: 830 YISVPTASEF-TDMGRTGGGVGPKGGVLLCPPRPCL-----TPTPS--------EGSLAN 875
Query: 1373 GWGSASEEDNISSGRSSVSSSDGSFFTDADFAQAVAAAAEYAGLKVARRQMQDAAGRRHF 1432
GWGSASE++ S+ S VSSSDGSF DA FA+A+A A + G + R+ A
Sbjct: 876 GWGSASEDNAASARASLVSSSDGSFLADAHFARALAVAVDSFGFGLEPRE----ADCVFI 931
Query: 1433 HASQCPRPTSPVSTDSNMSAAVMQKTRPAKKLKHQPGHLRRETYTDDLPPPPVPPPAIKS 1492
AS P P + N+S + + RP + H +R +PP P P I S
Sbjct: 932 DASSPPSPRDEIFLTPNLSLPLWE-WRPDWLEDMEVSHTQR--LGRGMPPWP-PDSQISS 987
Query: 1493 PTAQ 1496
+Q
Sbjct: 988 QRSQ 991
Score = 176 bits (446), Expect = 2e-43
Identities = 92/218 (42%), Positives = 123/218 (56%), Gaps = 9/218 (4%)
Query: 64 EDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLP 123
+D PP+I+ HP D + PA ++C+A G+P PTI W G+ + DP LLP
Sbjct: 28 QDSPPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHH---LLP 84
Query: 124 SGSLFFLR------IVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPS 177
G+L L+ G+ D GVY C A N LG AVS A L VA+LR+DF+ P
Sbjct: 85 DGTLLLLQPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPR 144
Query: 178 DVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGK 237
D++ VGE +EC PP GHPEPT+SW KDG PL + R T+ GG L++ KSD G
Sbjct: 145 DMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMARAEKSDEGT 204
Query: 238 YVCVGTNMVGERESEVAELTVLERPSFVKRPSNLAVTV 275
Y+CV TN G RES A +++ E + + LAV +
Sbjct: 205 YMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRI 242
Score = 77.4 bits (189), Expect = 1e-13
Identities = 101/423 (23%), Positives = 158/423 (37%), Gaps = 58/423 (13%)
Query: 262 PSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL---PKSRYEIRDDHTLKIR 318
P + P + A C+A G P PT+RW + L P + + D TL +
Sbjct: 32 PQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLL 91
Query: 319 KVTA-----------GDMGSYTCVAENMVGKA-EASATLTVQE-PPHFVVKPRDQVVALG 365
+ A D+G YTC A N +G A A L+V F ++PRD V +G
Sbjct: 92 QPPARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVG 151
Query: 366 RTVTFQC-EATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVG 424
T +C G+P+P + W ++G + QP R +VS G L + ++SD G
Sbjct: 152 EQFTLECGPPWGHPEPTVSWWKDGKP---LALQP----GRHTVS-GGSLLMARAEKSDEG 203
Query: 425 YYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVP 484
Y+C N AG ++A D PV + + ++ +L+ P P
Sbjct: 204 TYMCVATNSAGHRESRAARVSIQEPQDYTEPV---ELLAVRIQLENVTLLNPDPAEGPKP 260
Query: 485 T----ILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYT--CIASTPSGEATWSA 538
+ W+ G Q + + + A G + +A S E
Sbjct: 261 RPAVWLSWKVSGPAAPAQS------YTALFRTQTAPGGQGAPWAEELLAGWQSAELGGLH 314
Query: 539 YIEVQEFGVPVQPPRPTDPN----------LIPSAPSKPEVTDVSRNTVTLSW--QPNLN 586
+ + EF V R P+ +PSAP + TV +SW P N
Sbjct: 315 WGQDYEFKVRPSSGRARGPDSNVLLLRLPEKVPSAPPQEVTLKPGNGTVFVSWVPPPAEN 374
Query: 587 SGATPTSYIIEAFSHAS--GSSWQTVAENVKTETSAIKGLKPNAIYLFLVRAANAYGISD 644
Y + + + S ++W V E + E I P + Y V A G +
Sbjct: 375 HNGIIRGYQVWSLGNTSLPPANWTVVGEQTQLE---IATHMPGS-YCVQVAAVTGAGAGE 430
Query: 645 PSQ 647
PS+
Sbjct: 431 PSR 433
Score = 73.6 bits (179), Expect = 2e-12
Identities = 65/225 (28%), Positives = 93/225 (41%), Gaps = 24/225 (10%)
Query: 175 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLD--DKDERITIRGGKLMITY--- 229
+P D + PA M CQ G P PTI W +G PL D + G L++
Sbjct: 37 HPQDQLFQGPGPARMSCQAS-GQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLLLQPPA 95
Query: 230 --------TRKSDAGKYVCVGTNMVGERESEVAELTV-LERPSFVKRPSNLAVTVDDSAE 280
+D G Y C +N +G S A L+V + R F +P ++ V +
Sbjct: 96 RGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLREDFQIQPRDMVAVVGEQFT 155
Query: 281 FKCEAR-GDPVPTVRWRKDDGELP--KSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVG 337
+C G P PTV W KD L R+ + L R D G+Y CVA N G
Sbjct: 156 LECGPPWGHPEPTVSWWKDGKPLALQPGRHTVSGGSLLMAR-AEKSDEGTYMCVATNSAG 214
Query: 338 KAEA-SATLTVQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPA 381
E+ +A +++QEP + + V L + + NP PA
Sbjct: 215 HRESRAARVSIQEPQDYT----EPVELLAVRIQLENVTLLNPDPA 255
Score = 68.2 bits (165), Expect = 6e-11
Identities = 81/320 (25%), Positives = 121/320 (37%), Gaps = 54/320 (16%)
Query: 350 PPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGS--------------QNLLFS 395
PP +V P+DQ+ C+A+G P P I W G L
Sbjct: 31 PPQILVHPQDQLFQGPGPARMSCQASGQPPPTIRWLLNGQPLSMVPPDPHHLLPDGTLLL 90
Query: 396 YQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK-AYLEVTDVIADRPP 454
QPP G +D+G Y C+ N G+ +++ A L V + D
Sbjct: 91 LQPP---------ARGHAHDGQALSTDLGVYTCEASNRLGTAVSRGARLSVAVLRED--- 138
Query: 455 PVIRQGPVNQTVAVDGTFVLSC-VATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIR 513
+ P + V F L C G P PT+ W KDG ++ Q R + G L +
Sbjct: 139 --FQIQPRDMVAVVGEQFTLECGPPWGHPEPTVSWWKDGKPLALQPGR-HTVSGGSLLMA 195
Query: 514 YAKLGDTGRYTCIASTPSG-EATWSAYIEVQE----------FGVPVQPPRPTDPNLIPS 562
A+ D G Y C+A+ +G + +A + +QE V +Q T N P+
Sbjct: 196 RAEKSDEGTYMCVATNSAGHRESRAARVSIQEPQDYTEPVELLAVRIQLENVTLLNPDPA 255
Query: 563 APSKPEVTDVSRNTVTLSWQPNLNSGATPTSYIIEAF--SHASGSSWQTVAENVKT--ET 618
KP R V LSW+ ++ A P F A G AE + ++
Sbjct: 256 EGPKP------RPAVWLSWK--VSGPAAPAQSYTALFRTQTAPGGQGAPWAEELLAGWQS 307
Query: 619 SAIKGLKPNAIYLFLVRAAN 638
+ + GL Y F VR ++
Sbjct: 308 AELGGLHWGQDYEFKVRPSS 327
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.130 0.387
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 76,966,395
Number of Sequences: 37866
Number of extensions: 4310933
Number of successful extensions: 35478
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 306
Number of HSP's successfully gapped in prelim test: 731
Number of HSP's that attempted gapping in prelim test: 19087
Number of HSP's gapped (non-prelim): 8875
length of query: 1651
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1535
effective length of database: 13,855,062
effective search space: 21267520170
effective search space used: 21267520170
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.