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Search of human proteins with 4506499
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506499 regulatory factor X-associated ankyrin-containing
protein isoform a [Homo sapiens]
(260 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506499 regulatory factor X-associated ankyrin-containing pro... 521 e-148
gi|19924156 regulatory factor X-associated ankyrin-containing pr... 457 e-129
gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo sapi... 241 4e-64
gi|55741641 kinase D-interacting substrate of 220 kDa [Homo sapi... 85 6e-17
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is... 82 4e-16
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens] 80 2e-15
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens] 80 2e-15
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens] 80 2e-15
gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3 ... 79 4e-15
gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2 ... 79 4e-15
gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1 ... 79 4e-15
gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens] 79 4e-15
gi|42734375 ankyrin repeat and sterile alpha motif domain contai... 79 4e-15
gi|156142199 euchromatic histone-lysine N-methyltransferase 2 is... 77 1e-14
gi|156142197 euchromatic histone-lysine N-methyltransferase 2 is... 77 1e-14
gi|62988328 ankyrin repeat domain 50 [Homo sapiens] 77 2e-14
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens] 76 3e-14
gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo sap... 75 7e-14
gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo sap... 75 7e-14
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens] 74 1e-13
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens] 74 1e-13
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens] 74 1e-13
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens] 74 1e-13
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens] 74 1e-13
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 72 5e-13
gi|116534990 ankyrin-like protein 1 [Homo sapiens] 71 8e-13
gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ... 71 8e-13
gi|16975496 cortactin binding protein 2 [Homo sapiens] 71 1e-12
gi|24233530 ankyrin repeat domain 44 [Homo sapiens] 70 1e-12
gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens] 70 1e-12
>gi|4506499 regulatory factor X-associated ankyrin-containing
protein isoform a [Homo sapiens]
Length = 260
Score = 521 bits (1341), Expect = e-148
Identities = 260/260 (100%), Positives = 260/260 (100%)
Query: 1 MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS 60
MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS
Sbjct: 1 MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS 60
Query: 61 PQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKP 120
PQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKP
Sbjct: 61 PQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKP 120
Query: 121 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 180
DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD
Sbjct: 121 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 180
Query: 181 VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 240
VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ
Sbjct: 181 VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 240
Query: 241 VIENHILKLFQSNLVPADPE 260
VIENHILKLFQSNLVPADPE
Sbjct: 241 VIENHILKLFQSNLVPADPE 260
>gi|19924156 regulatory factor X-associated ankyrin-containing
protein isoform b [Homo sapiens]
Length = 237
Score = 457 bits (1177), Expect = e-129
Identities = 236/260 (90%), Positives = 236/260 (90%), Gaps = 23/260 (8%)
Query: 1 MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS 60
MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS
Sbjct: 1 MELTQPAEDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSS 60
Query: 61 PQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKP 120
PQ GSSLKHSTTLTNRQRGNEVSALPATLD DNLVNKP
Sbjct: 61 PQ-GSSLKHSTTLTNRQRGNEVSALPATLDC----------------------DNLVNKP 97
Query: 121 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 180
DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD
Sbjct: 98 DERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERD 157
Query: 181 VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 240
VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ
Sbjct: 158 VDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 217
Query: 241 VIENHILKLFQSNLVPADPE 260
VIENHILKLFQSNLVPADPE
Sbjct: 218 VIENHILKLFQSNLVPADPE 237
>gi|12746412 ankyrin repeat, family A (RFXANK-like), 2 [Homo
sapiens]
Length = 313
Score = 241 bits (616), Expect = 4e-64
Identities = 122/188 (64%), Positives = 145/188 (77%), Gaps = 1/188 (0%)
Query: 65 SSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERG 124
S +K STTLTN+ RGNEVS P +SLS+HQLAAQGE+ L + + +N++N DE G
Sbjct: 124 SPIKQSTTLTNKHRGNEVSTTPLLANSLSVHQLAAQGEMLYLATRIEQ-ENVINHTDEEG 182
Query: 125 FTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
FTPL+WA+A G+I V FLL+ GADP +L K RESALSLA + GYTDIV +LL+ VD+N
Sbjct: 183 FTPLMWAAAHGQIAVVEFLLQNGADPQLLGKGRESALSLACSKGYTDIVKMLLDCGVDVN 242
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
YDWNGGTPLLYAV GNHVKCV+ LL GAD T E DSGY MDLAVALGYR VQQVIE+
Sbjct: 243 EYDWNGGTPLLYAVHGNHVKCVKMLLESGADPTIETDSGYNSMDLAVALGYRSVQQVIES 302
Query: 245 HILKLFQS 252
H+LKL Q+
Sbjct: 303 HLLKLLQN 310
>gi|55741641 kinase D-interacting substrate of 220 kDa [Homo
sapiens]
Length = 1771
Score = 85.1 bits (209), Expect = 6e-17
Identities = 51/147 (34%), Positives = 84/147 (57%), Gaps = 2/147 (1%)
Query: 100 QGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 159
+G + ++E L+ G NL ++ D G+T L+WA G + V LL GA+P +
Sbjct: 81 EGHVHIVEELLKCGVNLEHR-DMGGWTALMWACYKGRTDVVELLLSHGANPSVTGLYSVY 139
Query: 160 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 219
+ A+ G+ DIV LLL+ +N D G TPL++A R H++CV+ LLA GAD+ E
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
Query: 220 ADSGYTPMDLAVALGY-RKVQQVIENH 245
+ T + +AV GY + V+++++ +
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRN 226
Score = 74.3 bits (181), Expect = 1e-13
Identities = 49/145 (33%), Positives = 77/145 (53%), Gaps = 1/145 (0%)
Query: 98 AAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKER 157
A +G D + L+ G VN D+ G TPL+WA+ G +E V+ LL GAD
Sbjct: 145 AGRGHADIVHLLLQNGAK-VNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQEGANS 203
Query: 158 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 217
+AL +A GGYT V +L+R+ ++N+ D +G T L+ A + H + V+ LL G +
Sbjct: 204 MTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQDLLDAGTYVN 263
Query: 218 TEADSGYTPMDLAVALGYRKVQQVI 242
SG T + AV G+ ++ + +
Sbjct: 264 IPDRSGDTVLIGAVRGGHVEIVRAL 288
Score = 66.6 bits (161), Expect = 2e-11
Identities = 44/138 (31%), Positives = 73/138 (52%)
Query: 105 QLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
++ + L VN PD G T LI A G +E VR LL+ AD I ++ ++AL A
Sbjct: 250 EIVQDLLDAGTYVNIPDRSGDTVLIGAVRGGHVEIVRALLQKYADIDIRGQDNKTALYWA 309
Query: 165 STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 224
G +V +L+ + D I +G TPL+ A + +++ VE LL +GA ++ G
Sbjct: 310 VEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSAVDKKGD 369
Query: 225 TPMDLAVALGYRKVQQVI 242
TP+ +A+ RK+ +++
Sbjct: 370 TPLHIAIRGRSRKLAELL 387
Score = 53.5 bits (127), Expect = 2e-07
Identities = 44/156 (28%), Positives = 77/156 (49%), Gaps = 1/156 (0%)
Query: 87 ATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 146
+ L S S+ + + LK L K + V++ +E G TPL+ A+ G +E V+ L++
Sbjct: 2 SVLISQSVINYVEEENIPALKALLEKCKD-VDERNECGQTPLMIAAEQGNLEIVKELIKN 60
Query: 147 GADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 206
GA+ ++ + +AL AS G+ IV LL+ V++ D G T L++A V
Sbjct: 61 GANCNLEDLDNWTALISASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVV 120
Query: 207 EALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
E LL+ GA+ + P+ A G+ + ++
Sbjct: 121 ELLLSHGANPSVTGLYSVYPIIWAAGRGHADIVHLL 156
Score = 51.2 bits (121), Expect = 9e-07
Identities = 32/114 (28%), Positives = 56/114 (49%)
Query: 127 PLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIY 186
P+IWA+ G + V LL+ GA + K + L A+ G+ + V LL D++
Sbjct: 140 PIIWAAGRGHADIVHLLLQNGAKVNCSDKYGTTPLVWAARKGHLECVKHLLAMGADVDQE 199
Query: 187 DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ 240
N T L+ AV+G + + V+ +L R ++ G T + +A G+ ++ Q
Sbjct: 200 GANSMTALIVAVKGGYTQSVKEILKRNPNVNLTDKDGNTALMIASKEGHTEIVQ 253
Score = 51.2 bits (121), Expect = 9e-07
Identities = 35/107 (32%), Positives = 50/107 (46%), Gaps = 3/107 (2%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T L WA G VR +L+ D I K+ E+ L A+ ++V LLL++ ++
Sbjct: 304 TALYWAVEKGNATMVRDILQCNPDTEICTKDGETPLIKATKMRNIEVVELLLDKGAKVSA 363
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGAD---LTTEADSGYTPMDL 229
D G TPL A+RG K E LL D L +G TP ++
Sbjct: 364 VDKKGDTPLHIAIRGRSRKLAELLLRNPKDGRLLYRPNKAGETPYNI 410
Score = 39.7 bits (91), Expect = 0.003
Identities = 30/109 (27%), Positives = 52/109 (47%)
Query: 137 IETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
I ++ LLE D + ++ L +A+ G +IV L++ + N+ D + T L+
Sbjct: 18 IPALKALLEKCKDVDERNECGQTPLMIAAEQGNLEIVKELIKNGANCNLEDLDNWTALIS 77
Query: 197 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A + HV VE LL G +L G+T + A G V +++ +H
Sbjct: 78 ASKEGHVHIVEELLKCGVNLEHRDMGGWTALMWACYKGRTDVVELLLSH 126
>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
isoform 1 [Homo sapiens]
Length = 1298
Score = 82.4 bits (202), Expect = 4e-16
Identities = 46/140 (32%), Positives = 73/140 (52%)
Query: 91 SLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADP 150
S +H A +G + ++ L G VN D+ G+TP+IWA+ + ++ V+ LL G+D
Sbjct: 840 STCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDI 899
Query: 151 HILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
+I E L A+ G DI +LL D++ + +G +PL A R N CV L
Sbjct: 900 NIRDNEENICLHWAAFSGCVDIAEILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFL 959
Query: 211 ARGADLTTEADSGYTPMDLA 230
+R +D+T + G TP+ A
Sbjct: 960 SRDSDVTLKNKEGETPLQCA 979
Score = 55.1 bits (131), Expect = 6e-08
Identities = 39/131 (29%), Positives = 67/131 (51%), Gaps = 5/131 (3%)
Query: 119 KPDERGFTP--LIWASAFGEIETVRFLLEWGADPHILAKE--RESALSLASTGGYTDIVG 174
KP + F P L +++ GE++ V +L G DP+ + + S L A+ G+ DI
Sbjct: 731 KPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICH 790
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
+L++ +I+ + TPL+ A NH++ V+ L+ GA + + G T + LA G
Sbjct: 791 MLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKG 850
Query: 235 -YRKVQQVIEN 244
Y VQ ++ N
Sbjct: 851 HYEVVQYLLSN 861
Score = 47.0 bits (110), Expect = 2e-05
Identities = 45/190 (23%), Positives = 84/190 (44%), Gaps = 14/190 (7%)
Query: 47 PEPVNPEPDASVSSPQAGSS-------LKHSTTLTNRQRGNEVSALPATLDSLSIHQLAA 99
PE +P A + P G S L+ + + ++ ++ P L + A
Sbjct: 693 PEGFDPTGPAGLGRPTPGLSQGPGKETLESALIALDSEKPKKLRFHPKQL-----YFSAR 747
Query: 100 QGELDQLKEHLRKG-DNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE 158
QGEL ++ L G D + +PL A+ G ++ L++ GA+ ++++
Sbjct: 748 QGELQKVLLMLVDGIDPNFKMEHQNKRSPLHAAAEAGHVDICHMLVQAGANIDTCSEDQR 807
Query: 159 SALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG-ADLT 217
+ L A+ + + V L++ ++ D G T L A + H + V+ LL+ G D+
Sbjct: 808 TPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVN 867
Query: 218 TEADSGYTPM 227
+ D G+TPM
Sbjct: 868 CQDDGGWTPM 877
>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
Length = 1863
Score = 79.7 bits (195), Expect = 2e-15
Identities = 46/150 (30%), Positives = 82/150 (54%), Gaps = 1/150 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
S + A G LD++ E+L+ G + +N ++ G L A+ G + V+ LL G+
Sbjct: 13 SFLRAARAGNLDKVVEYLKGGID-INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS 71
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K+ +AL +AS G ++V +L++ +IN NG TPL A + NH+ V+ LL
Sbjct: 72 ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 131
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVI 242
GA+ +T + G+TP+ +A+ G+ + ++
Sbjct: 132 GANQSTATEDGFTPLAVALQQGHNQAVAIL 161
Score = 72.8 bits (177), Expect = 3e-13
Identities = 44/115 (38%), Positives = 62/115 (53%)
Query: 116 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 175
+VN+ E GFTPL A+ +G + LL GA A+ + L +AS G T++V L
Sbjct: 204 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 263
Query: 176 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 230
LL+R I+ +G TPL A R H + VE LL RGA L +G +P+ +A
Sbjct: 264 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 318
Score = 68.2 bits (165), Expect = 7e-12
Identities = 45/127 (35%), Positives = 70/127 (55%), Gaps = 4/127 (3%)
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 181
+ G+TPL A+ +++ LL +GA+ +I+ K+ + L LAS G+TD+V LLL++
Sbjct: 606 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 665
Query: 182 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 241
+I++ +G T L A + + V + L GAD GYTP L VA Y V+ V
Sbjct: 666 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP--LIVACHYGNVKMV 723
Query: 242 IENHILK 248
N +LK
Sbjct: 724 --NFLLK 728
Score = 67.4 bits (163), Expect = 1e-11
Identities = 42/131 (32%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+V K +G TPL AS G + V LL+ GA+ H+ K ++L LA+ ++
Sbjct: 635 NIVTK---QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 691
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
+L + D + + G TPL+ A +VK V LL +GA++ + +GYTP+ A G
Sbjct: 692 ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 751
Query: 235 YRKVQQVIENH 245
+ + V+ H
Sbjct: 752 HTHIINVLLQH 762
Score = 65.9 bits (159), Expect = 3e-11
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 9/179 (5%)
Query: 78 RGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEI 137
RG ++ A T D L+ AA+ DQ+ E L + + + G +PL A+ +
Sbjct: 267 RGGQIDA--KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 324
Query: 138 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
E V+ LL+ A + + +AL +A+ G+ + LLL++ + N NG TPL A
Sbjct: 325 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 384
Query: 198 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVP 256
+ N +K +E L+ GA + +SG TP+ +A +G+ N +L L Q+ P
Sbjct: 385 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL-------NIVLLLLQNGASP 436
Score = 63.9 bits (154), Expect = 1e-10
Identities = 51/152 (33%), Positives = 73/152 (48%), Gaps = 7/152 (4%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDE---RGFTPLIWASAFGEIETVRFLLEWGADP 150
IH A G L+ + L+ G + PD RG T L A+ G++E VR LL GA
Sbjct: 414 IHVAAFMGHLNIVLLLLQNGAS----PDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 469
Query: 151 HILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
A+E ++ L +AS G T+IV LLL+ + NG TPL + R V LL
Sbjct: 470 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 529
Query: 211 ARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
GA + G+TP+ +A G V +++
Sbjct: 530 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 561
Score = 63.5 bits (153), Expect = 2e-10
Identities = 46/152 (30%), Positives = 65/152 (42%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G LD K L++ + + G TPL A+ + + LLE GA PH
Sbjct: 546 LHVAAKYGSLDVAKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 604
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK + L +A+ I LL + NI G TPL A + H V LL +G
Sbjct: 605 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 664
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A++ SG T + LA V ++ H
Sbjct: 665 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 696
Score = 59.7 bits (143), Expect = 2e-09
Identities = 48/160 (30%), Positives = 76/160 (47%), Gaps = 2/160 (1%)
Query: 88 TLDSLS-IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 146
TLD L+ +H A G K L K N N GFTPL A I+ + L+++
Sbjct: 341 TLDYLTALHVAAHCGHYRVTKLLLDKRAN-PNARALNGFTPLHIACKKNRIKVMELLVKY 399
Query: 147 GADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 206
GA + + + + +A+ G+ +IV LLL+ ++ + G T L A R V+ V
Sbjct: 400 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 459
Query: 207 EALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 246
LL GA + A TP+ +A LG ++ Q++ H+
Sbjct: 460 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 499
Score = 59.3 bits (142), Expect = 3e-09
Identities = 37/122 (30%), Positives = 61/122 (50%)
Query: 124 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 183
G+TPL ++ G+++ LLE GA + K+ + L +A+ G D+ LLL+R
Sbjct: 509 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 568
Query: 184 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
+ NG TPL A ++ K LL +GA A +GYTP+ +A ++ +
Sbjct: 569 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 628
Query: 244 NH 245
N+
Sbjct: 629 NY 630
Score = 58.2 bits (139), Expect = 7e-09
Identities = 40/132 (30%), Positives = 65/132 (49%)
Query: 87 ATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 146
+T L+ LAAQ + + + L K + + G+TPLI A +G ++ V FLL+
Sbjct: 670 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 729
Query: 147 GADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 206
GA+ + K + L A+ G+T I+ +LL+ N NG T L A R ++ V
Sbjct: 730 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 789
Query: 207 EALLARGADLTT 218
+ L ++TT
Sbjct: 790 DTLKVVTEEVTT 801
Score = 57.8 bits (138), Expect = 9e-09
Identities = 43/149 (28%), Positives = 70/149 (46%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G ++ L +G V+ G TPL AS G V+ LL+ G
Sbjct: 216 LHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 274
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
++ + L A+ G+ +V LLLER + NG +PL A +G+HV+CV+ LL
Sbjct: 275 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 334
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A + T + +A G+ +V +++
Sbjct: 335 APVDDVTLDYLTALHVAAHCGHYRVTKLL 363
Score = 57.4 bits (137), Expect = 1e-08
Identities = 53/177 (29%), Positives = 86/177 (48%), Gaps = 18/177 (10%)
Query: 78 RGNEV-SALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGE 136
RG+ V SA +L I LA Q E+ +K +++G N +N + GFTPL A+
Sbjct: 65 RGSSVDSATKKGNTALHIASLAGQAEV--VKVLVKEGAN-INAQSQNGFTPLYMAAQENH 121
Query: 137 IETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
I+ V++LLE GA+ ++ + L++A G+ V +LLE D + P L+
Sbjct: 122 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV-----RLPALH 176
Query: 197 -AVRGNHVKCVEALLA--RGADLTTE------ADSGYTPMDLAVALGYRKVQQVIEN 244
A R + K LL AD+ ++ +SG+TP+ +A G V ++ N
Sbjct: 177 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233
Score = 57.0 bits (136), Expect = 2e-08
Identities = 41/150 (27%), Positives = 66/150 (44%), Gaps = 1/150 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + +G D + L KG N ++ + G T L A+ ++ L + GAD
Sbjct: 645 LHLASQEGHTDMVTLLLDKGAN-IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 703
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K + L +A G +V LL++ ++N NG TPL A + H + LL G
Sbjct: 704 TKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 763
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
A +G T + +A LGY V ++
Sbjct: 764 AKPNATTANGNTALAIAKRLGYISVVDTLK 793
Score = 55.1 bits (131), Expect = 6e-08
Identities = 41/146 (28%), Positives = 68/146 (46%), Gaps = 1/146 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+++ ++ LR G LV+ TPL AS G+ E V+ LL+ A P
Sbjct: 446 ALHMAARAGQVEVVRCLLRNGA-LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 504
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
+ L +++ G D+ +LLE ++ G TPL A + + + LL R
Sbjct: 505 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 564
Query: 213 GADLTTEADSGYTPMDLAVALGYRKV 238
A + +G TP+ +A +KV
Sbjct: 565 RAAADSAGKNGLTPLHVAAHYDNQKV 590
Score = 53.9 bits (128), Expect = 1e-07
Identities = 36/121 (29%), Positives = 55/121 (45%)
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 181
E G TP+ A+ G + V LL+ GA P + E+AL +A+ G ++V LL
Sbjct: 408 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 467
Query: 182 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 241
++ TPL A R + V+ LL A +GYTP+ ++ G V V
Sbjct: 468 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 527
Query: 242 I 242
+
Sbjct: 528 L 528
Score = 50.1 bits (118), Expect = 2e-06
Identities = 34/118 (28%), Positives = 64/118 (54%), Gaps = 1/118 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A +G + ++E L +G + V+ ++G T L AS G+ E V+ L++ GA+ +
Sbjct: 46 ALHLAAKEGHVGLVQELLGRGSS-VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 104
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
++ + L +A+ + D+V LLE + + +G TPL A++ H + V LL
Sbjct: 105 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 162
>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
Length = 1872
Score = 79.7 bits (195), Expect = 2e-15
Identities = 46/150 (30%), Positives = 82/150 (54%), Gaps = 1/150 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
S + A G LD++ E+L+ G + +N ++ G L A+ G + V+ LL G+
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGID-INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS 92
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K+ +AL +AS G ++V +L++ +IN NG TPL A + NH+ V+ LL
Sbjct: 93 ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVI 242
GA+ +T + G+TP+ +A+ G+ + ++
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 72.8 bits (177), Expect = 3e-13
Identities = 44/115 (38%), Positives = 62/115 (53%)
Query: 116 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 175
+VN+ E GFTPL A+ +G + LL GA A+ + L +AS G T++V L
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
Query: 176 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 230
LL+R I+ +G TPL A R H + VE LL RGA L +G +P+ +A
Sbjct: 285 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 68.2 bits (165), Expect = 7e-12
Identities = 45/127 (35%), Positives = 70/127 (55%), Gaps = 4/127 (3%)
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 181
+ G+TPL A+ +++ LL +GA+ +I+ K+ + L LAS G+TD+V LLL++
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 182 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 241
+I++ +G T L A + + V + L GAD GYTP L VA Y V+ V
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP--LIVACHYGNVKMV 744
Query: 242 IENHILK 248
N +LK
Sbjct: 745 --NFLLK 749
Score = 67.4 bits (163), Expect = 1e-11
Identities = 42/131 (32%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+V K +G TPL AS G + V LL+ GA+ H+ K ++L LA+ ++
Sbjct: 656 NIVTK---QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 712
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
+L + D + + G TPL+ A +VK V LL +GA++ + +GYTP+ A G
Sbjct: 713 ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 772
Query: 235 YRKVQQVIENH 245
+ + V+ H
Sbjct: 773 HTHIINVLLQH 783
Score = 65.9 bits (159), Expect = 3e-11
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 9/179 (5%)
Query: 78 RGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEI 137
RG ++ A T D L+ AA+ DQ+ E L + + + G +PL A+ +
Sbjct: 288 RGGQIDA--KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 138 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
E V+ LL+ A + + +AL +A+ G+ + LLL++ + N NG TPL A
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Query: 198 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVP 256
+ N +K +E L+ GA + +SG TP+ +A +G+ N +L L Q+ P
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL-------NIVLLLLQNGASP 457
Score = 63.9 bits (154), Expect = 1e-10
Identities = 51/152 (33%), Positives = 73/152 (48%), Gaps = 7/152 (4%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDE---RGFTPLIWASAFGEIETVRFLLEWGADP 150
IH A G L+ + L+ G + PD RG T L A+ G++E VR LL GA
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGAS----PDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 151 HILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
A+E ++ L +AS G T+IV LLL+ + NG TPL + R V LL
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
Query: 211 ARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
GA + G+TP+ +A G V +++
Sbjct: 551 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 63.5 bits (153), Expect = 2e-10
Identities = 46/152 (30%), Positives = 65/152 (42%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G LD K L++ + + G TPL A+ + + LLE GA PH
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK + L +A+ I LL + NI G TPL A + H V LL +G
Sbjct: 626 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A++ SG T + LA V ++ H
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 59.7 bits (143), Expect = 2e-09
Identities = 48/160 (30%), Positives = 76/160 (47%), Gaps = 2/160 (1%)
Query: 88 TLDSLS-IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 146
TLD L+ +H A G K L K N N GFTPL A I+ + L+++
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRAN-PNARALNGFTPLHIACKKNRIKVMELLVKY 420
Query: 147 GADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 206
GA + + + + +A+ G+ +IV LLL+ ++ + G T L A R V+ V
Sbjct: 421 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
Query: 207 EALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 246
LL GA + A TP+ +A LG ++ Q++ H+
Sbjct: 481 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Score = 59.3 bits (142), Expect = 3e-09
Identities = 37/122 (30%), Positives = 61/122 (50%)
Query: 124 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 183
G+TPL ++ G+++ LLE GA + K+ + L +A+ G D+ LLL+R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 184 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
+ NG TPL A ++ K LL +GA A +GYTP+ +A ++ +
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 244 NH 245
N+
Sbjct: 650 NY 651
Score = 58.2 bits (139), Expect = 7e-09
Identities = 40/132 (30%), Positives = 65/132 (49%)
Query: 87 ATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 146
+T L+ LAAQ + + + L K + + G+TPLI A +G ++ V FLL+
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
Query: 147 GADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 206
GA+ + K + L A+ G+T I+ +LL+ N NG T L A R ++ V
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 207 EALLARGADLTT 218
+ L ++TT
Sbjct: 811 DTLKVVTEEVTT 822
Score = 57.8 bits (138), Expect = 9e-09
Identities = 43/149 (28%), Positives = 70/149 (46%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G ++ L +G V+ G TPL AS G V+ LL+ G
Sbjct: 237 LHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
++ + L A+ G+ +V LLLER + NG +PL A +G+HV+CV+ LL
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A + T + +A G+ +V +++
Sbjct: 356 APVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 57.4 bits (137), Expect = 1e-08
Identities = 53/177 (29%), Positives = 86/177 (48%), Gaps = 18/177 (10%)
Query: 78 RGNEV-SALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGE 136
RG+ V SA +L I LA Q E+ +K +++G N +N + GFTPL A+
Sbjct: 86 RGSSVDSATKKGNTALHIASLAGQAEV--VKVLVKEGAN-INAQSQNGFTPLYMAAQENH 142
Query: 137 IETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
I+ V++LLE GA+ ++ + L++A G+ V +LLE D + P L+
Sbjct: 143 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV-----RLPALH 197
Query: 197 -AVRGNHVKCVEALLA--RGADLTTE------ADSGYTPMDLAVALGYRKVQQVIEN 244
A R + K LL AD+ ++ +SG+TP+ +A G V ++ N
Sbjct: 198 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Score = 57.0 bits (136), Expect = 2e-08
Identities = 41/150 (27%), Positives = 66/150 (44%), Gaps = 1/150 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + +G D + L KG N ++ + G T L A+ ++ L + GAD
Sbjct: 666 LHLASQEGHTDMVTLLLDKGAN-IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K + L +A G +V LL++ ++N NG TPL A + H + LL G
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
A +G T + +A LGY V ++
Sbjct: 785 AKPNATTANGNTALAIAKRLGYISVVDTLK 814
Score = 55.1 bits (131), Expect = 6e-08
Identities = 41/146 (28%), Positives = 68/146 (46%), Gaps = 1/146 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+++ ++ LR G LV+ TPL AS G+ E V+ LL+ A P
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGA-LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
+ L +++ G D+ +LLE ++ G TPL A + + + LL R
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 213 GADLTTEADSGYTPMDLAVALGYRKV 238
A + +G TP+ +A +KV
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKV 611
Score = 53.9 bits (128), Expect = 1e-07
Identities = 36/121 (29%), Positives = 55/121 (45%)
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 181
E G TP+ A+ G + V LL+ GA P + E+AL +A+ G ++V LL
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 182 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 241
++ TPL A R + V+ LL A +GYTP+ ++ G V V
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 242 I 242
+
Sbjct: 549 L 549
Score = 50.1 bits (118), Expect = 2e-06
Identities = 34/118 (28%), Positives = 64/118 (54%), Gaps = 1/118 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A +G + ++E L +G + V+ ++G T L AS G+ E V+ L++ GA+ +
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSS-VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
++ + L +A+ + D+V LLE + + +G TPL A++ H + V LL
Sbjct: 126 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
Length = 3957
Score = 79.7 bits (195), Expect = 2e-15
Identities = 46/150 (30%), Positives = 82/150 (54%), Gaps = 1/150 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
S + A G LD++ E+L+ G + +N ++ G L A+ G + V+ LL G+
Sbjct: 34 SFLRAARAGNLDKVVEYLKGGID-INTCNQNGLNALHLAAKEGHVGLVQELLGRGSSVDS 92
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K+ +AL +AS G ++V +L++ +IN NG TPL A + NH+ V+ LL
Sbjct: 93 ATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYLLEN 152
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVI 242
GA+ +T + G+TP+ +A+ G+ + ++
Sbjct: 153 GANQSTATEDGFTPLAVALQQGHNQAVAIL 182
Score = 72.8 bits (177), Expect = 3e-13
Identities = 44/115 (38%), Positives = 62/115 (53%)
Query: 116 LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGL 175
+VN+ E GFTPL A+ +G + LL GA A+ + L +AS G T++V L
Sbjct: 225 MVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKL 284
Query: 176 LLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 230
LL+R I+ +G TPL A R H + VE LL RGA L +G +P+ +A
Sbjct: 285 LLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMA 339
Score = 68.2 bits (165), Expect = 7e-12
Identities = 45/127 (35%), Positives = 70/127 (55%), Gaps = 4/127 (3%)
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 181
+ G+TPL A+ +++ LL +GA+ +I+ K+ + L LAS G+TD+V LLL++
Sbjct: 627 KNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGA 686
Query: 182 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 241
+I++ +G T L A + + V + L GAD GYTP L VA Y V+ V
Sbjct: 687 NIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTP--LIVACHYGNVKMV 744
Query: 242 IENHILK 248
N +LK
Sbjct: 745 --NFLLK 749
Score = 67.4 bits (163), Expect = 1e-11
Identities = 42/131 (32%), Positives = 68/131 (51%), Gaps = 3/131 (2%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+V K +G TPL AS G + V LL+ GA+ H+ K ++L LA+ ++
Sbjct: 656 NIVTK---QGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVAD 712
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
+L + D + + G TPL+ A +VK V LL +GA++ + +GYTP+ A G
Sbjct: 713 ILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQG 772
Query: 235 YRKVQQVIENH 245
+ + V+ H
Sbjct: 773 HTHIINVLLQH 783
Score = 65.9 bits (159), Expect = 3e-11
Identities = 52/179 (29%), Positives = 87/179 (48%), Gaps = 9/179 (5%)
Query: 78 RGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEI 137
RG ++ A T D L+ AA+ DQ+ E L + + + G +PL A+ +
Sbjct: 288 RGGQIDA--KTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHV 345
Query: 138 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
E V+ LL+ A + + +AL +A+ G+ + LLL++ + N NG TPL A
Sbjct: 346 ECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKLLLDKRANPNARALNGFTPLHIA 405
Query: 198 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVP 256
+ N +K +E L+ GA + +SG TP+ +A +G+ N +L L Q+ P
Sbjct: 406 CKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHL-------NIVLLLLQNGASP 457
Score = 63.9 bits (154), Expect = 1e-10
Identities = 51/152 (33%), Positives = 73/152 (48%), Gaps = 7/152 (4%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDE---RGFTPLIWASAFGEIETVRFLLEWGADP 150
IH A G L+ + L+ G + PD RG T L A+ G++E VR LL GA
Sbjct: 435 IHVAAFMGHLNIVLLLLQNGAS----PDVTNIRGETALHMAARAGQVEVVRCLLRNGALV 490
Query: 151 HILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
A+E ++ L +AS G T+IV LLL+ + NG TPL + R V LL
Sbjct: 491 DARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLL 550
Query: 211 ARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
GA + G+TP+ +A G V +++
Sbjct: 551 EAGAAHSLATKKGFTPLHVAAKYGSLDVAKLL 582
Score = 63.5 bits (153), Expect = 2e-10
Identities = 46/152 (30%), Positives = 65/152 (42%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G LD K L++ + + G TPL A+ + + LLE GA PH
Sbjct: 567 LHVAAKYGSLDVAKLLLQRRA-AADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHAT 625
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK + L +A+ I LL + NI G TPL A + H V LL +G
Sbjct: 626 AKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKG 685
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A++ SG T + LA V ++ H
Sbjct: 686 ANIHMSTKSGLTSLHLAAQEDKVNVADILTKH 717
Score = 59.7 bits (143), Expect = 2e-09
Identities = 48/160 (30%), Positives = 76/160 (47%), Gaps = 2/160 (1%)
Query: 88 TLDSLS-IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 146
TLD L+ +H A G K L K N N GFTPL A I+ + L+++
Sbjct: 362 TLDYLTALHVAAHCGHYRVTKLLLDKRAN-PNARALNGFTPLHIACKKNRIKVMELLVKY 420
Query: 147 GADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 206
GA + + + + +A+ G+ +IV LLL+ ++ + G T L A R V+ V
Sbjct: 421 GASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVV 480
Query: 207 EALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHI 246
LL GA + A TP+ +A LG ++ Q++ H+
Sbjct: 481 RCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQHM 520
Score = 59.3 bits (142), Expect = 3e-09
Identities = 37/122 (30%), Positives = 61/122 (50%)
Query: 124 GFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDI 183
G+TPL ++ G+++ LLE GA + K+ + L +A+ G D+ LLL+R
Sbjct: 530 GYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAA 589
Query: 184 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
+ NG TPL A ++ K LL +GA A +GYTP+ +A ++ +
Sbjct: 590 DSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLL 649
Query: 244 NH 245
N+
Sbjct: 650 NY 651
Score = 58.2 bits (139), Expect = 7e-09
Identities = 40/132 (30%), Positives = 65/132 (49%)
Query: 87 ATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 146
+T L+ LAAQ + + + L K + + G+TPLI A +G ++ V FLL+
Sbjct: 691 STKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQ 750
Query: 147 GADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 206
GA+ + K + L A+ G+T I+ +LL+ N NG T L A R ++ V
Sbjct: 751 GANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVV 810
Query: 207 EALLARGADLTT 218
+ L ++TT
Sbjct: 811 DTLKVVTEEVTT 822
Score = 57.8 bits (138), Expect = 9e-09
Identities = 43/149 (28%), Positives = 70/149 (46%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G ++ L +G V+ G TPL AS G V+ LL+ G
Sbjct: 237 LHIAAHYGNVNVATLLLNRGA-AVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAK 295
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
++ + L A+ G+ +V LLLER + NG +PL A +G+HV+CV+ LL
Sbjct: 296 TRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHK 355
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A + T + +A G+ +V +++
Sbjct: 356 APVDDVTLDYLTALHVAAHCGHYRVTKLL 384
Score = 57.4 bits (137), Expect = 1e-08
Identities = 53/177 (29%), Positives = 86/177 (48%), Gaps = 18/177 (10%)
Query: 78 RGNEV-SALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGE 136
RG+ V SA +L I LA Q E+ +K +++G N +N + GFTPL A+
Sbjct: 86 RGSSVDSATKKGNTALHIASLAGQAEV--VKVLVKEGAN-INAQSQNGFTPLYMAAQENH 142
Query: 137 IETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
I+ V++LLE GA+ ++ + L++A G+ V +LLE D + P L+
Sbjct: 143 IDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKV-----RLPALH 197
Query: 197 -AVRGNHVKCVEALLA--RGADLTTE------ADSGYTPMDLAVALGYRKVQQVIEN 244
A R + K LL AD+ ++ +SG+TP+ +A G V ++ N
Sbjct: 198 IAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254
Score = 57.0 bits (136), Expect = 2e-08
Identities = 41/150 (27%), Positives = 66/150 (44%), Gaps = 1/150 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + +G D + L KG N ++ + G T L A+ ++ L + GAD
Sbjct: 666 LHLASQEGHTDMVTLLLDKGAN-IHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAH 724
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K + L +A G +V LL++ ++N NG TPL A + H + LL G
Sbjct: 725 TKLGYTPLIVACHYGNVKMVNFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHG 784
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
A +G T + +A LGY V ++
Sbjct: 785 AKPNATTANGNTALAIAKRLGYISVVDTLK 814
Score = 55.1 bits (131), Expect = 6e-08
Identities = 41/146 (28%), Positives = 68/146 (46%), Gaps = 1/146 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+++ ++ LR G LV+ TPL AS G+ E V+ LL+ A P
Sbjct: 467 ALHMAARAGQVEVVRCLLRNGA-LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDA 525
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
+ L +++ G D+ +LLE ++ G TPL A + + + LL R
Sbjct: 526 ATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQR 585
Query: 213 GADLTTEADSGYTPMDLAVALGYRKV 238
A + +G TP+ +A +KV
Sbjct: 586 RAAADSAGKNGLTPLHVAAHYDNQKV 611
Score = 53.9 bits (128), Expect = 1e-07
Identities = 36/121 (29%), Positives = 55/121 (45%)
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 181
E G TP+ A+ G + V LL+ GA P + E+AL +A+ G ++V LL
Sbjct: 429 ESGLTPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGA 488
Query: 182 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 241
++ TPL A R + V+ LL A +GYTP+ ++ G V V
Sbjct: 489 LVDARAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASV 548
Query: 242 I 242
+
Sbjct: 549 L 549
Score = 50.1 bits (118), Expect = 2e-06
Identities = 34/118 (28%), Positives = 64/118 (54%), Gaps = 1/118 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A +G + ++E L +G + V+ ++G T L AS G+ E V+ L++ GA+ +
Sbjct: 67 ALHLAAKEGHVGLVQELLGRGSS-VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINA 125
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
++ + L +A+ + D+V LLE + + +G TPL A++ H + V LL
Sbjct: 126 QSQNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFTPLAVALQQGHNQAVAILL 183
>gi|46519154 ankyrin repeat and KH domain containing 1 isoform 3
[Homo sapiens]
Length = 627
Score = 79.0 bits (193), Expect = 4e-15
Identities = 55/177 (31%), Positives = 94/177 (53%), Gaps = 4/177 (2%)
Query: 70 STTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLI 129
+ LT + N +A +D+ S+ + + G+++ +++ L +G + VN+ E G + L
Sbjct: 187 AAALTRMKAENSHNA--GQVDTRSLAEACSDGDVNAVRKLLDEGRS-VNEHTEEGESLLC 243
Query: 130 WASAFGEIETVRFLLEWGADPHILAKERE-SALSLASTGGYTDIVGLLLERDVDINIYDW 188
A + G E + LL A+ + + + L AS+GGY DIV LLL D D+N
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
Query: 189 NGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
G T L YA G V V+ LL GA++ ++G+TP+ A + G+ +V +V+ +H
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 74.7 bits (182), Expect = 7e-14
Identities = 48/140 (34%), Positives = 78/140 (55%), Gaps = 2/140 (1%)
Query: 100 QGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 159
+G LD ++ L G + +K DE T L+ A G +E R LL+ GA ++ A ES
Sbjct: 382 KGHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 440
Query: 160 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 219
L+LA+ GG+ ++ LL+ER ++ + G TPL+ A R H + V LLA+GA++ +
Sbjct: 441 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
Query: 220 A-DSGYTPMDLAVALGYRKV 238
++ T + LA G+ +V
Sbjct: 501 TEETQETALTLACCGGFSEV 520
Score = 67.4 bits (163), Expect = 1e-11
Identities = 44/143 (30%), Positives = 70/143 (48%)
Query: 96 QLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 155
+ A+ G ++ + L G + +E + L A G ++ VRFLLE GAD
Sbjct: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403
Query: 156 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
E +AL A G+ ++ LLL+ +N+ + +PL A G HV+ L+ RGA+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
Query: 216 LTTEADSGYTPMDLAVALGYRKV 238
L D GYTP+ A G+ ++
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEM 486
Score = 67.4 bits (163), Expect = 1e-11
Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 5/159 (3%)
Query: 85 LPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLL 144
+PA + A G ++ + +G NL DE G+TPL+ A+ G E V LL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLMEAAREGHEEMVALLL 491
Query: 145 EWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
GA+ + +E +E+AL+LA GG++++ L++ DI + TPL+ A + H+
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
+ V+ LLA GA++ +G T + A G+ V V+
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 64.7 bits (156), Expect = 8e-11
Identities = 36/107 (33%), Positives = 60/107 (56%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+ ++ ++ TPL+ AS+ G ++ V+ LL AD + + +AL+ A GG+ DIV
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 221
+LL +I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Score = 45.4 bits (106), Expect = 5e-05
Identities = 22/59 (37%), Positives = 36/59 (61%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
TPL+ AS G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D++
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 595
>gi|46519151 ankyrin repeat and KH domain containing 1 isoform 2
[Homo sapiens]
Length = 616
Score = 79.0 bits (193), Expect = 4e-15
Identities = 55/177 (31%), Positives = 94/177 (53%), Gaps = 4/177 (2%)
Query: 70 STTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLI 129
+ LT + N +A +D+ S+ + + G+++ +++ L +G + VN+ E G + L
Sbjct: 176 AAALTRMKAENSHNA--GQVDTRSLAEACSDGDVNAVRKLLDEGRS-VNEHTEEGESLLC 232
Query: 130 WASAFGEIETVRFLLEWGADPHILAKERE-SALSLASTGGYTDIVGLLLERDVDINIYDW 188
A + G E + LL A+ + + + L AS+GGY DIV LLL D D+N
Sbjct: 233 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 292
Query: 189 NGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
G T L YA G V V+ LL GA++ ++G+TP+ A + G+ +V +V+ +H
Sbjct: 293 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 349
Score = 74.7 bits (182), Expect = 7e-14
Identities = 48/140 (34%), Positives = 78/140 (55%), Gaps = 2/140 (1%)
Query: 100 QGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 159
+G LD ++ L G + +K DE T L+ A G +E R LL+ GA ++ A ES
Sbjct: 371 KGHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 429
Query: 160 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 219
L+LA+ GG+ ++ LL+ER ++ + G TPL+ A R H + V LLA+GA++ +
Sbjct: 430 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 489
Query: 220 A-DSGYTPMDLAVALGYRKV 238
++ T + LA G+ +V
Sbjct: 490 TEETQETALTLACCGGFSEV 509
Score = 67.4 bits (163), Expect = 1e-11
Identities = 44/143 (30%), Positives = 70/143 (48%)
Query: 96 QLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 155
+ A+ G ++ + L G + +E + L A G ++ VRFLLE GAD
Sbjct: 333 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 392
Query: 156 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
E +AL A G+ ++ LLL+ +N+ + +PL A G HV+ L+ RGA+
Sbjct: 393 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 452
Query: 216 LTTEADSGYTPMDLAVALGYRKV 238
L D GYTP+ A G+ ++
Sbjct: 453 LEEVNDEGYTPLMEAAREGHEEM 475
Score = 67.4 bits (163), Expect = 1e-11
Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 5/159 (3%)
Query: 85 LPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLL 144
+PA + A G ++ + +G NL DE G+TPL+ A+ G E V LL
Sbjct: 422 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLMEAAREGHEEMVALLL 480
Query: 145 EWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
GA+ + +E +E+AL+LA GG++++ L++ DI + TPL+ A + H+
Sbjct: 481 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHL 537
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
+ V+ LLA GA++ +G T + A G+ V V+
Sbjct: 538 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 576
Score = 64.7 bits (156), Expect = 8e-11
Identities = 36/107 (33%), Positives = 60/107 (56%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+ ++ ++ TPL+ AS+ G ++ V+ LL AD + + +AL+ A GG+ DIV
Sbjct: 252 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 311
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 221
+LL +I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 312 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 358
Score = 45.4 bits (106), Expect = 5e-05
Identities = 22/59 (37%), Positives = 36/59 (61%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
TPL+ AS G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D++
Sbjct: 526 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLD 584
>gi|46519147 ankyrin repeat and KH domain containing 1 isoform 1
[Homo sapiens]
Length = 2542
Score = 79.0 bits (193), Expect = 4e-15
Identities = 55/177 (31%), Positives = 94/177 (53%), Gaps = 4/177 (2%)
Query: 70 STTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLI 129
+ LT + N +A +D+ S+ + + G+++ +++ L +G + VN+ E G + L
Sbjct: 187 AAALTRMKAENSHNA--GQVDTRSLAEACSDGDVNAVRKLLDEGRS-VNEHTEEGESLLC 243
Query: 130 WASAFGEIETVRFLLEWGADPHILAKERE-SALSLASTGGYTDIVGLLLERDVDINIYDW 188
A + G E + LL A+ + + + L AS+GGY DIV LLL D D+N
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
Query: 189 NGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
G T L YA G V V+ LL GA++ ++G+TP+ A + G+ +V +V+ +H
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 74.7 bits (182), Expect = 7e-14
Identities = 48/140 (34%), Positives = 78/140 (55%), Gaps = 2/140 (1%)
Query: 100 QGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 159
+G LD ++ L G + +K DE T L+ A G +E R LL+ GA ++ A ES
Sbjct: 382 KGHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 440
Query: 160 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 219
L+LA+ GG+ ++ LL+ER ++ + G TPL+ A R H + V LLA+GA++ +
Sbjct: 441 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
Query: 220 A-DSGYTPMDLAVALGYRKV 238
++ T + LA G+ +V
Sbjct: 501 TEETQETALTLACCGGFSEV 520
Score = 72.4 bits (176), Expect = 4e-13
Identities = 41/121 (33%), Positives = 70/121 (57%), Gaps = 1/121 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
TPL+ AS G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D+
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 244
G TPL+ A R H+ V+ L+++GA++ A++ +T + LA A G+ V +++
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 245 H 245
H
Sbjct: 657 H 657
Score = 71.2 bits (173), Expect = 8e-13
Identities = 65/226 (28%), Positives = 100/226 (44%), Gaps = 16/226 (7%)
Query: 16 TPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSLKH---STT 72
TPA L D D A + T E + PE + +S A S+ S
Sbjct: 987 TPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVD 1046
Query: 73 LTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWAS 132
+ N +AL LA G ++L L D + D++GFTPLI A+
Sbjct: 1047 IDAHTESNHDTALT----------LACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAA 1096
Query: 133 AFGEIETVRFLLEWGADPHILA-KERESALSLASTGGYTDIVGLLLERDVDINIYDWNGG 191
G + V LL+ G D + + +++ LSLA +GG ++V LLL R + + +
Sbjct: 1097 TAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY 1156
Query: 192 TPLLYAVRGNHVKCVEALLARGADLTTEADS--GYTPMDLAVALGY 235
TPL A G +V ++ LL GA++ + S G +P+ LA G+
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202
Score = 68.9 bits (167), Expect = 4e-12
Identities = 52/184 (28%), Positives = 91/184 (49%), Gaps = 9/184 (4%)
Query: 79 GNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIE 138
G++++A T + ++ QG + + L + N+ ++ + G TPL+ A++ G E
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAE 1271
Query: 139 TVRFLLEWGADPHI--LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
R LL+ GAD + + R++AL++A+ G+ LL+ R I++ + G TPL
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
Query: 197 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVP 256
A G H V+ L+ GAD+ + TP+ A G+ KV Q + + N P
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV------NQFP 1385
Query: 257 ADPE 260
+D E
Sbjct: 1386 SDIE 1389
Score = 67.4 bits (163), Expect = 1e-11
Identities = 44/143 (30%), Positives = 70/143 (48%)
Query: 96 QLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 155
+ A+ G ++ + L G + +E + L A G ++ VRFLLE GAD
Sbjct: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403
Query: 156 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
E +AL A G+ ++ LLL+ +N+ + +PL A G HV+ L+ RGA+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
Query: 216 LTTEADSGYTPMDLAVALGYRKV 238
L D GYTP+ A G+ ++
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEM 486
Score = 67.4 bits (163), Expect = 1e-11
Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 5/159 (3%)
Query: 85 LPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLL 144
+PA + A G ++ + +G NL DE G+TPL+ A+ G E V LL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLMEAAREGHEEMVALLL 491
Query: 145 EWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
GA+ + +E +E+AL+LA GG++++ L++ DI + TPL+ A + H+
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
+ V+ LLA GA++ +G T + A G+ V V+
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 64.7 bits (156), Expect = 8e-11
Identities = 36/107 (33%), Positives = 60/107 (56%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+ ++ ++ TPL+ AS+ G ++ V+ LL AD + + +AL+ A GG+ DIV
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 221
+LL +I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Score = 57.4 bits (137), Expect = 1e-08
Identities = 31/86 (36%), Positives = 52/86 (60%), Gaps = 1/86 (1%)
Query: 158 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 217
++AL+LA GG+ ++V +L+ RD I D G TPL+ A HV VE LL +G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 218 TEAD-SGYTPMDLAVALGYRKVQQVI 242
+++ + TP+ LA + G ++V ++
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLL 1141
Score = 55.8 bits (133), Expect = 4e-08
Identities = 41/120 (34%), Positives = 60/120 (50%), Gaps = 1/120 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T L A A G E V L+ A K+ + L LA+T G+ +V +LL++ DI
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 186 Y-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
+ TPL A G + V+ LLARGA+ S YTP+ LA + GY + +++ N
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Score = 53.1 bits (126), Expect = 2e-07
Identities = 44/133 (33%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 79 GNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIE 138
G V A AT D+ ++ G D L+ G +L ++ E G TPL+ A+ G +
Sbjct: 558 GANVHATTATGDT-ALTYACENGHTDVADVLLQAGADLEHE-SEGGRTPLMKAARAGHLC 615
Query: 139 TVRFLLEWGADPH-ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
TV+FL+ GA+ + A + +SLA GG+ +V LLL D +G T L+ A
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675
Query: 198 VRGNHVKCVEALL 210
+G H V LL
Sbjct: 676 AKGGHTNVVSYLL 688
Score = 53.1 bits (126), Expect = 2e-07
Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 3/167 (1%)
Query: 79 GNEVSALPATLDSLSIHQLAAQ-GELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEI 137
G E+++ + +S LAA G + +K L G ++ + + T L A G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 138 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI--YDWNGGTPLL 195
E V LL+ A+ AK + L A++GGY ++ +LL++ D+N + T L
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 196 YAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A H K E L+ RGA + G TP+ LA G+ V Q++
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Score = 40.0 bits (92), Expect = 0.002
Identities = 33/117 (28%), Positives = 50/117 (42%), Gaps = 16/117 (13%)
Query: 62 QAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPD 121
QAG+ L+H + G + A A G L ++ + KG N+
Sbjct: 589 QAGADLEHES------EGGRTPLMKA----------ARAGHLCTVQFLISKGANVNRATA 632
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLE 178
T + A A G + V LL GADP K+ + L A+ GG+T++V LL+
Sbjct: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 36.2 bits (82), Expect = 0.029
Identities = 21/63 (33%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 181 VDINIY-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQ 239
VDI+ + + N T L A G H + V L+AR A + G+TP+ LA G+ V
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
Query: 240 QVI 242
+++
Sbjct: 1105 EIL 1107
>gi|37620163 ANKHD1-EIF4EBP3 protein [Homo sapiens]
Length = 2617
Score = 79.0 bits (193), Expect = 4e-15
Identities = 55/177 (31%), Positives = 94/177 (53%), Gaps = 4/177 (2%)
Query: 70 STTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLI 129
+ LT + N +A +D+ S+ + + G+++ +++ L +G + VN+ E G + L
Sbjct: 187 AAALTRMKAENSHNA--GQVDTRSLAEACSDGDVNAVRKLLDEGRS-VNEHTEEGESLLC 243
Query: 130 WASAFGEIETVRFLLEWGADPHILAKERE-SALSLASTGGYTDIVGLLLERDVDINIYDW 188
A + G E + LL A+ + + + L AS+GGY DIV LLL D D+N
Sbjct: 244 LACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSA 303
Query: 189 NGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
G T L YA G V V+ LL GA++ ++G+TP+ A + G+ +V +V+ +H
Sbjct: 304 TGNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDH 360
Score = 74.7 bits (182), Expect = 7e-14
Identities = 48/140 (34%), Positives = 78/140 (55%), Gaps = 2/140 (1%)
Query: 100 QGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 159
+G LD ++ L G + +K DE T L+ A G +E R LL+ GA ++ A ES
Sbjct: 382 KGHLDMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 440
Query: 160 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 219
L+LA+ GG+ ++ LL+ER ++ + G TPL+ A R H + V LLA+GA++ +
Sbjct: 441 PLTLAACGGHVELAALLIERGANLEEVNDEGYTPLMEAAREGHEEMVALLLAQGANINAQ 500
Query: 220 A-DSGYTPMDLAVALGYRKV 238
++ T + LA G+ +V
Sbjct: 501 TEETQETALTLACCGGFSEV 520
Score = 72.4 bits (176), Expect = 4e-13
Identities = 41/121 (33%), Positives = 70/121 (57%), Gaps = 1/121 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
TPL+ AS G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D+
Sbjct: 537 TPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 596
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 244
G TPL+ A R H+ V+ L+++GA++ A++ +T + LA A G+ V +++
Sbjct: 597 ESEGGRTPLMKAARAGHLCTVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLA 656
Query: 245 H 245
H
Sbjct: 657 H 657
Score = 71.2 bits (173), Expect = 8e-13
Identities = 65/226 (28%), Positives = 100/226 (44%), Gaps = 16/226 (7%)
Query: 16 TPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSLKH---STT 72
TPA L D D A + T E + PE + +S A S+ S
Sbjct: 987 TPAQTLTDTLDDLIAAVSTRVPTGSNSSSQTTECLTPESCSQTTSNVASQSMPPVYPSVD 1046
Query: 73 LTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWAS 132
+ N +AL LA G ++L L D + D++GFTPLI A+
Sbjct: 1047 IDAHTESNHDTALT----------LACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAA 1096
Query: 133 AFGEIETVRFLLEWGADPHILA-KERESALSLASTGGYTDIVGLLLERDVDINIYDWNGG 191
G + V LL+ G D + + +++ LSLA +GG ++V LLL R + + +
Sbjct: 1097 TAGHVGVVEILLDKGGDIEAQSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDY 1156
Query: 192 TPLLYAVRGNHVKCVEALLARGADLTTEADS--GYTPMDLAVALGY 235
TPL A G +V ++ LL GA++ + S G +P+ LA G+
Sbjct: 1157 TPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGH 1202
Score = 68.9 bits (167), Expect = 4e-12
Identities = 52/184 (28%), Positives = 91/184 (49%), Gaps = 9/184 (4%)
Query: 79 GNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIE 138
G++++A T + ++ QG + + L + N+ ++ + G TPL+ A++ G E
Sbjct: 1213 GSDINAQIETNRNTALTLACFQGRAEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAE 1271
Query: 139 TVRFLLEWGADPHI--LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
R LL+ GAD + + R++AL++A+ G+ LL+ R I++ + G TPL
Sbjct: 1272 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWL 1331
Query: 197 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVP 256
A G H V+ L+ GAD+ + TP+ A G+ KV Q + + N P
Sbjct: 1332 ASNGGHFDVVQLLVQAGADVDAADNRKITPLMSAFRKGHVKVVQYLVKEV------NQFP 1385
Query: 257 ADPE 260
+D E
Sbjct: 1386 SDIE 1389
Score = 67.4 bits (163), Expect = 1e-11
Identities = 44/143 (30%), Positives = 70/143 (48%)
Query: 96 QLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 155
+ A+ G ++ + L G + +E + L A G ++ VRFLLE GAD
Sbjct: 344 EAASAGHVEVARVLLDHGAGINTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTD 403
Query: 156 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
E +AL A G+ ++ LLL+ +N+ + +PL A G HV+ L+ RGA+
Sbjct: 404 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAN 463
Query: 216 LTTEADSGYTPMDLAVALGYRKV 238
L D GYTP+ A G+ ++
Sbjct: 464 LEEVNDEGYTPLMEAAREGHEEM 486
Score = 67.4 bits (163), Expect = 1e-11
Identities = 49/159 (30%), Positives = 82/159 (51%), Gaps = 5/159 (3%)
Query: 85 LPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLL 144
+PA + A G ++ + +G NL DE G+TPL+ A+ G E V LL
Sbjct: 433 MPADSFESPLTLAACGGHVELAALLIERGANLEEVNDE-GYTPLMEAAREGHEEMVALLL 491
Query: 145 EWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
GA+ + +E +E+AL+LA GG++++ L++ DI + TPL+ A + H+
Sbjct: 492 AQGANINAQTEETQETALTLACCGGFSEVADFLIKAGADIEL---GCSTPLMEASQEGHL 548
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
+ V+ LLA GA++ +G T + A G+ V V+
Sbjct: 549 ELVKYLLASGANVHATTATGDTALTYACENGHTDVADVL 587
Score = 64.7 bits (156), Expect = 8e-11
Identities = 36/107 (33%), Positives = 60/107 (56%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+ ++ ++ TPL+ AS+ G ++ V+ LL AD + + +AL+ A GG+ DIV
Sbjct: 263 NVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSATGNTALTYACAGGFVDIVK 322
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 221
+LL +I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 323 VLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGINTHSN 369
Score = 57.4 bits (137), Expect = 1e-08
Identities = 31/86 (36%), Positives = 52/86 (60%), Gaps = 1/86 (1%)
Query: 158 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 217
++AL+LA GG+ ++V +L+ RD I D G TPL+ A HV VE LL +G D+
Sbjct: 1056 DTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIE 1115
Query: 218 TEAD-SGYTPMDLAVALGYRKVQQVI 242
+++ + TP+ LA + G ++V ++
Sbjct: 1116 AQSERTKDTPLSLACSGGRQEVVDLL 1141
Score = 55.8 bits (133), Expect = 4e-08
Identities = 41/120 (34%), Positives = 60/120 (50%), Gaps = 1/120 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T L A A G E V L+ A K+ + L LA+T G+ +V +LL++ DI
Sbjct: 1057 TALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVVEILLDKGGDIEA 1116
Query: 186 Y-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
+ TPL A G + V+ LLARGA+ S YTP+ LA + GY + +++ N
Sbjct: 1117 QSERTKDTPLSLACSGGRQEVVDLLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1176
Score = 53.1 bits (126), Expect = 2e-07
Identities = 44/133 (33%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 79 GNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIE 138
G V A AT D+ ++ G D L+ G +L ++ E G TPL+ A+ G +
Sbjct: 558 GANVHATTATGDT-ALTYACENGHTDVADVLLQAGADLEHE-SEGGRTPLMKAARAGHLC 615
Query: 139 TVRFLLEWGADPH-ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
TV+FL+ GA+ + A + +SLA GG+ +V LLL D +G T L+ A
Sbjct: 616 TVQFLISKGANVNRATANNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 675
Query: 198 VRGNHVKCVEALL 210
+G H V LL
Sbjct: 676 AKGGHTNVVSYLL 688
Score = 53.1 bits (126), Expect = 2e-07
Identities = 48/167 (28%), Positives = 77/167 (46%), Gaps = 3/167 (1%)
Query: 79 GNEVSALPATLDSLSIHQLAAQ-GELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEI 137
G E+++ + +S LAA G + +K L G ++ + + T L A G
Sbjct: 1178 GAEINSRTGSKLGISPLMLAAMNGHVPAVKLLLDMGSDINAQIETNRNTALTLACFQGRA 1237
Query: 138 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI--YDWNGGTPLL 195
E V LL+ A+ AK + L A++GGY ++ +LL++ D+N + T L
Sbjct: 1238 EVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDTALT 1297
Query: 196 YAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A H K E L+ RGA + G TP+ LA G+ V Q++
Sbjct: 1298 IAADKGHYKFCELLIHRGAHIDVRNKKGNTPLWLASNGGHFDVVQLL 1344
Score = 40.0 bits (92), Expect = 0.002
Identities = 33/117 (28%), Positives = 50/117 (42%), Gaps = 16/117 (13%)
Query: 62 QAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPD 121
QAG+ L+H + G + A A G L ++ + KG N+
Sbjct: 589 QAGADLEHES------EGGRTPLMKA----------ARAGHLCTVQFLISKGANVNRATA 632
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLE 178
T + A A G + V LL GADP K+ + L A+ GG+T++V LL+
Sbjct: 633 NNDHTVVSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTNVVSYLLD 689
Score = 36.2 bits (82), Expect = 0.029
Identities = 21/63 (33%), Positives = 33/63 (52%), Gaps = 1/63 (1%)
Query: 181 VDINIY-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQ 239
VDI+ + + N T L A G H + V L+AR A + G+TP+ LA G+ V
Sbjct: 1045 VDIDAHTESNHDTALTLACAGGHEELVSVLIARDAKIEHRDKKGFTPLILAATAGHVGVV 1104
Query: 240 QVI 242
+++
Sbjct: 1105 EIL 1107
>gi|42734375 ankyrin repeat and sterile alpha motif domain
containing 3 [Homo sapiens]
Length = 656
Score = 79.0 bits (193), Expect = 4e-15
Identities = 50/159 (31%), Positives = 82/159 (51%), Gaps = 1/159 (0%)
Query: 92 LSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH 151
L +H A+ G+ + +KE +++ + +NK + G+TPL++AS G V LLE G +
Sbjct: 37 LDLHTAASIGQYEVVKECVQRRELDLNKKNGGGWTPLMYASYIGHDTIVHLLLEAGVSVN 96
Query: 152 ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLA 211
+ E ++ L LAS+ G I LL++ ++ + D G T L + H V LL
Sbjct: 97 VPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTALFHCTSAGHQHMVRFLLD 156
Query: 212 RGADLTT-EADSGYTPMDLAVALGYRKVQQVIENHILKL 249
GA+ E G+TP+ A A G+ + Q NH +K+
Sbjct: 157 SGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKV 195
Score = 38.9 bits (89), Expect = 0.005
Identities = 32/102 (31%), Positives = 51/102 (50%), Gaps = 10/102 (9%)
Query: 110 LRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERE-----SALSLA 164
L++G L K D +G+T L ++ G VRFLL+ GA+ ++ RE + L A
Sbjct: 122 LQQGAELEMK-DIQGWTALFHCTSAGHQHMVRFLLDSGANANV----REPICGFTPLMEA 176
Query: 165 STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCV 206
+ G+ IV L V ++ D +G T + A + H+K V
Sbjct: 177 AAAGHEIIVQYFLNHGVKVDARDHSGATARMLAKQYGHMKIV 218
Score = 32.3 bits (72), Expect = 0.42
Identities = 37/143 (25%), Positives = 53/143 (37%), Gaps = 1/143 (0%)
Query: 34 GSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLS 93
G DT+V L P P+ A S S Q+G E+ +
Sbjct: 80 GHDTIVHLLLEAGVSVNVPTPEGQTPLMLASSCGNESIAYFLLQQGAELEMKDIQGWTAL 139
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
H +A G ++ L G N + GFTPL+ A+A G V++ L G
Sbjct: 140 FHCTSA-GHQHMVRFLLDSGANANVREPICGFTPLMEAAAAGHEIIVQYFLNHGVKVDAR 198
Query: 154 AKERESALSLASTGGYTDIVGLL 176
+A LA G+ IV L+
Sbjct: 199 DHSGATARMLAKQYGHMKIVALM 221
>gi|156142199 euchromatic histone-lysine N-methyltransferase 2
isoform b [Homo sapiens]
Length = 1176
Score = 77.4 bits (189), Expect = 1e-14
Identities = 49/139 (35%), Positives = 67/139 (48%)
Query: 91 SLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADP 150
S +H A G L+ + L G VN D G+TP+IWA+ IE +R LL GAD
Sbjct: 718 STCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADV 777
Query: 151 HILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
+ E L AS G I +LL D++ +++G TPL A R ++ CV L
Sbjct: 778 TLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFL 837
Query: 211 ARGADLTTEADSGYTPMDL 229
+RGA+ G T DL
Sbjct: 838 SRGANPELRNKEGDTAWDL 856
Score = 64.3 bits (155), Expect = 1e-10
Identities = 42/152 (27%), Positives = 76/152 (50%), Gaps = 2/152 (1%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A +G ++ L+ G N +N D++ TPL+ A +E R++++ G +
Sbjct: 655 LHAAAQKGSVEICHVLLQAGAN-INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 713
Query: 154 AKERESALSLASTGGYTDIVGLLLER-DVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
++ + L A+ G ++V LLL VD+N D G TP+++A H++ + LL R
Sbjct: 714 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 773
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
GAD+T + + A G + +V+ N
Sbjct: 774 GADVTLTDNEENICLHWASFTGSAAIAEVLLN 805
Score = 45.1 bits (105), Expect = 6e-05
Identities = 28/102 (27%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 135 GEIETVRFLLEWGADPHILAKE--RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGT 192
GE++ V +L DP+ + + + + L A+ G +I +LL+ +IN D T
Sbjct: 627 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 686
Query: 193 PLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
PL+ AV NH++ ++ RG + ++ + G T + A +G
Sbjct: 687 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 728
>gi|156142197 euchromatic histone-lysine N-methyltransferase 2
isoform a [Homo sapiens]
Length = 1210
Score = 77.4 bits (189), Expect = 1e-14
Identities = 49/139 (35%), Positives = 67/139 (48%)
Query: 91 SLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADP 150
S +H A G L+ + L G VN D G+TP+IWA+ IE +R LL GAD
Sbjct: 752 STCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTRGADV 811
Query: 151 HILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
+ E L AS G I +LL D++ +++G TPL A R ++ CV L
Sbjct: 812 TLTDNEENICLHWASFTGSAAIAEVLLNARCDLHAVNYHGDTPLHIAARESYHDCVLLFL 871
Query: 211 ARGADLTTEADSGYTPMDL 229
+RGA+ G T DL
Sbjct: 872 SRGANPELRNKEGDTAWDL 890
Score = 64.3 bits (155), Expect = 1e-10
Identities = 42/152 (27%), Positives = 76/152 (50%), Gaps = 2/152 (1%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A +G ++ L+ G N +N D++ TPL+ A +E R++++ G +
Sbjct: 689 LHAAAQKGSVEICHVLLQAGAN-INAVDKQQRTPLMEAVVNNHLEVARYMVQRGGCVYSK 747
Query: 154 AKERESALSLASTGGYTDIVGLLLER-DVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
++ + L A+ G ++V LLL VD+N D G TP+++A H++ + LL R
Sbjct: 748 EEDGSTCLHHAAKIGNLEMVSLLLSTGQVDVNAQDSGGWTPIIWAAEHKHIEVIRMLLTR 807
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
GAD+T + + A G + +V+ N
Sbjct: 808 GADVTLTDNEENICLHWASFTGSAAIAEVLLN 839
Score = 45.1 bits (105), Expect = 6e-05
Identities = 28/102 (27%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 135 GEIETVRFLLEWGADPHILAKE--RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGT 192
GE++ V +L DP+ + + + + L A+ G +I +LL+ +IN D T
Sbjct: 661 GELQKVILMLLDNLDPNFQSDQQSKRTPLHAAAQKGSVEICHVLLQAGANINAVDKQQRT 720
Query: 193 PLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
PL+ AV NH++ ++ RG + ++ + G T + A +G
Sbjct: 721 PLMEAVVNNHLEVARYMVQRGGCVYSKEEDGSTCLHHAAKIG 762
>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
Length = 1429
Score = 76.6 bits (187), Expect = 2e-14
Identities = 53/157 (33%), Positives = 84/157 (53%), Gaps = 5/157 (3%)
Query: 87 ATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEW 146
A DS + + AA G + + +L + VNK D G T LI A+ G E V LL+
Sbjct: 640 ADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDH 699
Query: 147 GADPHILAKERESALSLA-----STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGN 201
GA+ + + +ALS+A ++ G+ +V LL++R +++ D +G TPLL A
Sbjct: 700 GAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEG 759
Query: 202 HVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
HV V+ LL GAD+ ++G TP+ A ++G+ V
Sbjct: 760 HVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASV 796
Score = 70.5 bits (171), Expect = 1e-12
Identities = 53/148 (35%), Positives = 74/148 (50%), Gaps = 2/148 (1%)
Query: 98 AAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKER 157
A +G +D + + L +G V+ D G TPL+ A++ G V LL WGA + E
Sbjct: 756 AYEGHVDVV-DLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814
Query: 158 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 217
+ LS+AS G ++V LL+R +D N D G TPL A H EAL+ +GA
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874
Query: 218 TEADSGYTPMDLAVALG-YRKVQQVIEN 244
+ G P LA G Y VQ ++EN
Sbjct: 875 EIDNDGRIPFILASQEGHYDCVQILLEN 902
Score = 63.5 bits (153), Expect = 2e-10
Identities = 44/153 (28%), Positives = 74/153 (48%), Gaps = 1/153 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
+++ LA + +L + L G N V D G T L + G +E V+ L+ + AD +
Sbjct: 949 TLYILALENQLTMAEYFLENGAN-VEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNA 1007
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
E+ SAL A+ G+ +V LL+E ++ G T L A + H+ V+ LL
Sbjct: 1008 ADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEH 1067
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
GAD G T M +A G+ ++ +++E +
Sbjct: 1068 GADPNHADQFGRTAMRVAAKNGHSQIIKLLEKY 1100
Score = 63.2 bits (152), Expect = 2e-10
Identities = 58/209 (27%), Positives = 95/209 (45%), Gaps = 7/209 (3%)
Query: 39 VLSLFPCTPEPVNPEPDASVSSPQAGSSLKHS--TTLTNRQRGNEVSALPATLDSLSIHQ 96
VL L VN E D + + + S T L N N+ + TL +
Sbjct: 496 VLQLLVKAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTL----LAN 551
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
A G LD + + +G +L + D G TPL A+ G + V L+ GA+ + ++
Sbjct: 552 AAYSGSLDVVNLLVSRGADLEIE-DAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQD 610
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+AL A+ GG+T++V LL V ++ D + T L A G H V LL GA++
Sbjct: 611 GWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEV 670
Query: 217 TTEADSGYTPMDLAVALGYRKVQQVIENH 245
+ G T + A +G+R++ + + +H
Sbjct: 671 NKADNEGRTALIAAAYMGHREIVEHLLDH 699
Score = 63.2 bits (152), Expect = 2e-10
Identities = 40/126 (31%), Positives = 63/126 (50%)
Query: 117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 176
V+ D+ G TPL+ A+ G ++ V LLE GAD + L A++ G+ +V L
Sbjct: 741 VDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTL 800
Query: 177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 236
L ++ D G T L A +V+ V LL RG D D+G+TP+ +A G+R
Sbjct: 801 LFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHR 860
Query: 237 KVQQVI 242
+ + +
Sbjct: 861 LICEAL 866
Score = 60.5 bits (145), Expect = 1e-09
Identities = 49/152 (32%), Positives = 71/152 (46%), Gaps = 11/152 (7%)
Query: 105 QLKEHLRKGDNLVNKPDERGFTPLIWAS-----AFGEIETVRFLLEWGADPHILAKERES 159
++ EHL VN D G T L A+ + G V L++ GA+ K+ +
Sbjct: 691 EIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMT 750
Query: 160 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 219
L +A+ G+ D+V LLLE D++ D NG TPLL A H V LL GA + +
Sbjct: 751 PLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSI 810
Query: 220 ADSGYTPMDLAVALGYRKVQQVI------ENH 245
G T + +A A G +V + + ENH
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENH 842
Score = 56.6 bits (135), Expect = 2e-08
Identities = 39/114 (34%), Positives = 56/114 (49%)
Query: 117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 176
+N D+ G+T L A+ G E V LL G + +AL A+ GG+ DIV L
Sbjct: 604 INHTDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNL 663
Query: 177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 230
L+ ++N D G T L+ A H + VE LL GA++ E G T + +A
Sbjct: 664 LQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVA 717
Score = 55.8 bits (133), Expect = 4e-08
Identities = 37/129 (28%), Positives = 62/129 (48%)
Query: 117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 176
V+ D G T L ASA G +E VR LL+ G D + + L +A+ G+ I L
Sbjct: 807 VDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEAL 866
Query: 177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 236
+E+ N D +G P + A + H CV+ LL +++ G + +A G+R
Sbjct: 867 IEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHR 926
Query: 237 KVQQVIENH 245
+ +++ +H
Sbjct: 927 DIVELLFSH 935
Score = 53.1 bits (126), Expect = 2e-07
Identities = 40/149 (26%), Positives = 67/149 (44%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A +G + + +G N+ D G P I AS G + V+ LLE ++
Sbjct: 851 LHMAAFEGHRLICEALIEQGAR-TNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQR 909
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ +AL +A+ G+ DIV LL D+N D +G L N + E L G
Sbjct: 910 GYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENG 969
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A++ G T + ++ G+ ++ QV+
Sbjct: 970 ANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Score = 51.6 bits (122), Expect = 7e-07
Identities = 44/148 (29%), Positives = 70/148 (47%), Gaps = 2/148 (1%)
Query: 98 AAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKER 157
+AQG ++ ++ L +G + N D+ G+TPL A+ G L+E GA + + +
Sbjct: 822 SAQGNVEVVRTLLDRGLD-ENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTNEIDNDG 880
Query: 158 ESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLT 217
LAS G+ D V +LLE +I+ ++G L A H VE L + GAD+
Sbjct: 881 RIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVN 940
Query: 218 -TEADSGYTPMDLAVALGYRKVQQVIEN 244
+AD T LA+ + +EN
Sbjct: 941 CKDADGRPTLYILALENQLTMAEYFLEN 968
Score = 48.1 bits (113), Expect = 7e-06
Identities = 35/129 (27%), Positives = 58/129 (44%)
Query: 117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 176
VN D G L + ++ + LE GA+ E +AL ++ G+ ++V +L
Sbjct: 939 VNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVL 998
Query: 177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 236
+ D+N D + L A HVK V+ L+ GA + + G T + +A G+
Sbjct: 999 IAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHI 1058
Query: 237 KVQQVIENH 245
V QV+ H
Sbjct: 1059 DVVQVLLEH 1067
Score = 45.8 bits (107), Expect = 4e-05
Identities = 30/98 (30%), Positives = 48/98 (48%)
Query: 117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 176
VN D + L A+ G ++ V+ L+E GA + +AL +A+ G+ D+V +L
Sbjct: 1005 VNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVL 1064
Query: 177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGA 214
LE D N D G T + A + H + ++ L GA
Sbjct: 1065 LEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGA 1102
>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
Length = 4377
Score = 76.3 bits (186), Expect = 3e-14
Identities = 48/175 (27%), Positives = 91/175 (52%), Gaps = 9/175 (5%)
Query: 68 KHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTP 127
KH +R++ ++ +A S + A G L++ ++++ G + +N ++ G
Sbjct: 27 KHRKRSRDRKKKSDANA--------SYLRAARAGHLEKALDYIKNGVD-INICNQNGLNA 77
Query: 128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYD 187
L AS G +E V LL+ A+ K+ +AL +AS G ++V +L+ ++N
Sbjct: 78 LHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS 137
Query: 188 WNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
NG TPL A + NH++ V+ LL GA + + G+TP+ +A+ G+ +V ++
Sbjct: 138 QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLL 192
Score = 74.7 bits (182), Expect = 7e-14
Identities = 39/128 (30%), Positives = 73/128 (57%)
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDV 181
+ G+TPL A+ +++ LLE+GAD + + ++ +++ LA+ G+ D+V LLL R+
Sbjct: 629 KNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNA 688
Query: 182 DINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQV 241
++N+ + +G TPL A + + V E L+ +GA + + GYTP+ + G K+
Sbjct: 689 NVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNF 748
Query: 242 IENHILKL 249
+ H K+
Sbjct: 749 LLQHSAKV 756
Score = 67.8 bits (164), Expect = 9e-12
Identities = 45/149 (30%), Positives = 74/149 (49%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
IH A G ++ + + + G + N + RG T L A+ G+ E VR+L++ GA
Sbjct: 437 IHVAAFMGHVNIVSQLMHHGAS-PNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAK 495
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK+ ++ L +++ G DIV LL++ N +G TPL + R H LL G
Sbjct: 496 AKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHG 555
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A L+ G+TP+ +A G +V ++
Sbjct: 556 ASLSITTKKGFTPLHVAAKYGKLEVANLL 584
Score = 65.5 bits (158), Expect = 5e-11
Identities = 45/153 (29%), Positives = 75/153 (49%), Gaps = 7/153 (4%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H + G+ + +K + G N VN + GFTPL A+ +E V+FLL+ GA +
Sbjct: 110 ALHIASLAGQAEVVKVLVTNGAN-VNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSL 168
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY-AVRGNHVKCVEALLA 211
++ + L++A G+ +V LLLE D + P L+ A R + K LL
Sbjct: 169 ATEDGFTPLAVALQQGHDQVVSLLLENDTKGKV-----RLPALHIAARKDDTKAAALLLQ 223
Query: 212 RGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
+ E+ SG+TP+ +A G V ++ N
Sbjct: 224 NDNNADVESKSGFTPLHIAAHYGNINVATLLLN 256
Score = 65.5 bits (158), Expect = 5e-11
Identities = 44/149 (29%), Positives = 72/149 (48%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
+AA+ + + L + DN + + GFTPL A+ +G I LL A A+
Sbjct: 208 IAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARN 267
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L +AS G ++V LLL+R I+ +G TPL R H + VE LL R A +
Sbjct: 268 DITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPI 327
Query: 217 TTEADSGYTPMDLAVALGYRKVQQVIENH 245
++ +G +P+ +A + Q++ H
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQH 356
Score = 63.2 bits (152), Expect = 2e-10
Identities = 44/168 (26%), Positives = 80/168 (47%), Gaps = 2/168 (1%)
Query: 78 RGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEI 137
RG ++ A T D L+ A+ +Q+ E L + + G +PL A+ +
Sbjct: 290 RGAKIDA--KTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHL 347
Query: 138 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
V+ LL+ + + +AL +A+ G+ + +LL++ + N NG TPL A
Sbjct: 348 NCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA 407
Query: 198 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
+ N +K +E LL GA + +SG TP+ +A +G+ + + +H
Sbjct: 408 CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHH 455
Score = 62.4 bits (150), Expect = 4e-10
Identities = 47/154 (30%), Positives = 77/154 (50%), Gaps = 2/154 (1%)
Query: 77 QRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGE 136
Q G +V A A D +H A G+ D +++ L++G + N G+TPL ++ G
Sbjct: 487 QDGAQVEA-KAKDDQTPLHISARLGKADIVQQLLQQGAS-PNAATTSGYTPLHLSAREGH 544
Query: 137 IETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
+ FLL+ GA I K+ + L +A+ G ++ LLL++ + +G TPL
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604
Query: 197 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLA 230
A ++ K LL +GA A +GYTP+ +A
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638
Score = 62.4 bits (150), Expect = 4e-10
Identities = 48/154 (31%), Positives = 68/154 (44%), Gaps = 7/154 (4%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPD---ERGFTPLIWASAFGEIETVRFLLEWGADP 150
+H A G+L+ L+K + PD + G TPL A+ + + LL+ GA P
Sbjct: 569 LHVAAKYGKLEVANLLLQKSAS----PDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASP 624
Query: 151 HILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
H AK + L +A+ DI LLE D N G + A + HV V LL
Sbjct: 625 HAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLL 684
Query: 211 ARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
R A++ SG TP+ LA V +V+ N
Sbjct: 685 GRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVN 718
Score = 61.6 bits (148), Expect = 7e-10
Identities = 39/141 (27%), Positives = 64/141 (45%)
Query: 105 QLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
++ E L K + E G TP+ A+ G + V L+ GA P+ E+AL +A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473
Query: 165 STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 224
+ G ++V L++ + + TPL + R V+ LL +GA SGY
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533
Query: 225 TPMDLAVALGYRKVQQVIENH 245
TP+ L+ G+ V + +H
Sbjct: 534 TPLHLSAREGHEDVAAFLLDH 554
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/146 (25%), Positives = 69/146 (47%), Gaps = 1/146 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+ + ++ ++ G + K + TPL ++ G+ + V+ LL+ GA P+
Sbjct: 469 ALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQ-TPLHISARLGKADIVQQLLQQGASPNA 527
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
+ L L++ G+ D+ LL+ ++I G TPL A + ++ LL +
Sbjct: 528 ATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK 587
Query: 213 GADLTTEADSGYTPMDLAVALGYRKV 238
A SG TP+ +A +KV
Sbjct: 588 SASPDAAGKSGLTPLHVAAHYDNQKV 613
Score = 55.5 bits (132), Expect = 5e-08
Identities = 35/117 (29%), Positives = 57/117 (48%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
TPL AS G V+ LL+ GA ++ + L + G+ +V +LL+R I
Sbjct: 270 TPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILS 329
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
NG +PL A +G+H+ CV+ LL + + T + +A G+ KV +V+
Sbjct: 330 KTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVL 386
Score = 50.8 bits (120), Expect = 1e-06
Identities = 42/152 (27%), Positives = 67/152 (44%), Gaps = 2/152 (1%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G K L K N N GFTPL A I+ + LL+ GA
Sbjct: 370 ALHVAAHCGHYKVAKVLLDKKAN-PNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQA 428
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
+ + + + +A+ G+ +IV L+ N + G T L A R + V L+
Sbjct: 429 VTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQD 488
Query: 213 GADLTTEADSGYTPMDLAVALGYRK-VQQVIE 243
GA + +A TP+ ++ LG VQQ+++
Sbjct: 489 GAQVEAKAKDDQTPLHISARLGKADIVQQLLQ 520
Score = 49.3 bits (116), Expect = 3e-06
Identities = 35/113 (30%), Positives = 54/113 (47%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
LAAQ + + E L V+ + G+TPL +G I+ V FLL+ A + K
Sbjct: 703 LAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKN 762
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 209
+ L A+ G+T I+ +LL+ + N NG T L A R ++ V+ L
Sbjct: 763 GYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTL 815
Score = 42.4 bits (98), Expect = 4e-04
Identities = 40/154 (25%), Positives = 64/154 (41%)
Query: 85 LPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLL 144
L T + LS +A QG+ + L + + V+ T L A+ G + + LL
Sbjct: 328 LSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLL 387
Query: 145 EWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVK 204
+ A+P+ A + L +A ++ LLL+ I +G TP+ A HV
Sbjct: 388 DKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVN 447
Query: 205 CVEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
V L+ GA T G T + +A G +V
Sbjct: 448 IVSQLMHHGASPNTTNVRGETALHMAARSGQAEV 481
>gi|38683807 ankyrin repeat domain protein 17 isoform a [Homo
sapiens]
Length = 2603
Score = 74.7 bits (182), Expect = 7e-14
Identities = 42/121 (34%), Positives = 71/121 (58%), Gaps = 1/121 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
TPL+ A+ G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 244
G TPL+ A R HV V+ L+++GA++ T A++ +T + LA A G+ V +++
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 245 H 245
H
Sbjct: 686 H 686
Score = 70.9 bits (172), Expect = 1e-12
Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 2/140 (1%)
Query: 100 QGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 159
+G L+ ++ L G + +K DE T L+ A G +E R LL+ GA ++ A ES
Sbjct: 411 KGHLEMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
Query: 160 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 219
L+LA+ GG+ ++ LL+ER + + G TPL+ A R H + V LL +GA++ +
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 220 A-DSGYTPMDLAVALGYRKV 238
++ T + LA G+ +V
Sbjct: 530 TEETQETALTLACCGGFLEV 549
Score = 69.3 bits (168), Expect = 3e-12
Identities = 51/184 (27%), Positives = 92/184 (50%), Gaps = 9/184 (4%)
Query: 79 GNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIE 138
G++++A T + ++ QG + + L + N+ ++ + G TPL+ A++ G E
Sbjct: 1241 GSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAE 1299
Query: 139 TVRFLLEWGADPHI--LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
R LL+ GAD + + R++AL++A+ G+ LL+ R I++ + G TPL
Sbjct: 1300 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWL 1359
Query: 197 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVP 256
A G H+ V+ L+ GAD+ + TP+ A G+ KV + + + N P
Sbjct: 1360 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEV------NQFP 1413
Query: 257 ADPE 260
+D E
Sbjct: 1414 SDSE 1417
Score = 67.4 bits (163), Expect = 1e-11
Identities = 44/143 (30%), Positives = 68/143 (47%)
Query: 96 QLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 155
+ + G ++ + L G + +E + L A G +E VRFLLE GAD
Sbjct: 373 EAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432
Query: 156 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
E +AL A G+ ++ LLL+ +N+ + +PL A G HV+ L+ RGA
Sbjct: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS 492
Query: 216 LTTEADSGYTPMDLAVALGYRKV 238
L D GYTP+ A G+ ++
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEM 515
Score = 67.0 bits (162), Expect = 2e-11
Identities = 50/178 (28%), Positives = 90/178 (50%), Gaps = 3/178 (1%)
Query: 66 SLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGF 125
+L + R R E +A D+ S+ + ++G+++ +++ L +G + VN+ E G
Sbjct: 211 ALDEAAAALTRMRA-ESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRS-VNEHTEEGE 268
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERE-SALSLASTGGYTDIVGLLLERDVDIN 184
+ L A + G E + LL A+ + + + L A+ GG+ IV LLL D+N
Sbjct: 269 SLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVN 328
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
G T L YA G +V V+ LL GA + ++G+TP+ A + G+ +V +++
Sbjct: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Score = 66.6 bits (161), Expect = 2e-11
Identities = 75/280 (26%), Positives = 117/280 (41%), Gaps = 58/280 (20%)
Query: 10 LIQTQQ-----TPASELGDPEDPGEEAADG-----SDTVVLSLFPCTPEPVNPEPDASVS 59
L +TQQ +PA L D D A G S+T S+ +P P P + +
Sbjct: 1003 LTETQQGLMVASPAQTLNDTLDDIMAAVSGRASAMSNTPTHSIAASISQPQTPTP-SPII 1061
Query: 60 SPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNK 119
SP A + + + + N +AL LA G ++L + L + +
Sbjct: 1062 SPSAMLPIYPAIDIDAQTESNHDTALT----------LACAGGHEELVQTLLERGASIEH 1111
Query: 120 PDERGFTPLIWASAFGEIETVRFLLEWGAD-----------PHILA-------------- 154
D++GFTPLI A+ G + V LL+ GAD P LA
Sbjct: 1112 RDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDTPLSLACSGGRQEVVELLLA 1171
Query: 155 ----KERESA-----LSLASTGGYTDIVGLLLERDVDINIYDWN--GGTPLLYAVRGNHV 203
KE + LSLA++GGY +I+ +LL +IN + G +PL+ A H
Sbjct: 1172 RGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSRTGSKLGISPLMLAAMNGHT 1231
Query: 204 KCVEALLARGADLTTEADSG-YTPMDLAVALGYRKVQQVI 242
V+ LL G+D+ + ++ T + LA G +V ++
Sbjct: 1232 AAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1271
Score = 65.1 bits (157), Expect = 6e-11
Identities = 48/159 (30%), Positives = 81/159 (50%), Gaps = 5/159 (3%)
Query: 85 LPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLL 144
+PA + A G ++ + +G +L DE G+TPL+ A+ G E V LL
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDE-GYTPLMEAAREGHEEMVALLL 520
Query: 145 EWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
GA+ + +E +E+AL+LA GG+ ++ L++ DI + TPL+ A + H+
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHL 577
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
+ V+ LLA GA++ +G T + A G+ V V+
Sbjct: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
Score = 63.9 bits (154), Expect = 1e-10
Identities = 36/107 (33%), Positives = 58/107 (54%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+ ++ + TPL+ A+ G ++ V+ LL AD + + +AL+ A GGY D+V
Sbjct: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 221
+LLE I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 352 VLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Score = 63.9 bits (154), Expect = 1e-10
Identities = 45/120 (37%), Positives = 62/120 (51%), Gaps = 1/120 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T L A A G E V+ LLE GA K+ + L LA+T G+ +V +LL+ DI
Sbjct: 1085 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 1144
Query: 186 Y-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
+ TPL A G + VE LLARGA+ S YTP+ LA + GY + +++ N
Sbjct: 1145 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 1204
Score = 55.8 bits (133), Expect = 4e-08
Identities = 47/170 (27%), Positives = 77/170 (45%), Gaps = 9/170 (5%)
Query: 75 NRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAF 134
N + G+++ P L +++ H A + LD G ++ + + T L A
Sbjct: 1210 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDM-------GSDINAQIETNRNTALTLACFQ 1262
Query: 135 GEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI--YDWNGGT 192
G E V LL+ A+ AK + L A++GGY ++ +LL++ D+N + T
Sbjct: 1263 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1322
Query: 193 PLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
L A H K E L+ RGA + G TP+ LA G+ V Q++
Sbjct: 1323 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1372
Score = 53.1 bits (126), Expect = 2e-07
Identities = 45/133 (33%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 79 GNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIE 138
G V A AT D+ ++ G D L+ G +L ++ E G TPL+ A+ G +
Sbjct: 587 GANVHATTATGDT-ALTYACENGHTDVADVLLQAGADLEHE-SEGGRTPLMKAARAGHVC 644
Query: 139 TVRFLLEWGADPH-ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
TV+FL+ GA+ + A + LSLA GG+ +V LLL D +G T L+ A
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 198 VRGNHVKCVEALL 210
+G H V LL
Sbjct: 705 AKGGHTSVVCYLL 717
Score = 38.5 bits (88), Expect = 0.006
Identities = 33/117 (28%), Positives = 49/117 (41%), Gaps = 16/117 (13%)
Query: 62 QAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPD 121
QAG+ L+H + G + A A G + ++ + KG N+
Sbjct: 618 QAGADLEHES------EGGRTPLMKA----------ARAGHVCTVQFLISKGANVNRTTA 661
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLE 178
T L A A G + V LL GADP K+ + L A+ GG+T +V LL+
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
>gi|38683816 ankyrin repeat domain protein 17 isoform b [Homo
sapiens]
Length = 2352
Score = 74.7 bits (182), Expect = 7e-14
Identities = 42/121 (34%), Positives = 71/121 (58%), Gaps = 1/121 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
TPL+ A+ G +E V++LL GA+ H ++AL+ A G+TD+ +LL+ D+
Sbjct: 566 TPLMEAAQEGHLELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVLLQAGADLEH 625
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLT-TEADSGYTPMDLAVALGYRKVQQVIEN 244
G TPL+ A R HV V+ L+++GA++ T A++ +T + LA A G+ V +++
Sbjct: 626 ESEGGRTPLMKAARAGHVCTVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLA 685
Query: 245 H 245
H
Sbjct: 686 H 686
Score = 70.9 bits (172), Expect = 1e-12
Identities = 46/140 (32%), Positives = 76/140 (54%), Gaps = 2/140 (1%)
Query: 100 QGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERES 159
+G L+ ++ L G + +K DE T L+ A G +E R LL+ GA ++ A ES
Sbjct: 411 KGHLEMVRFLLEAGADQEHKTDEM-HTALMEACMDGHVEVARLLLDSGAQVNMPADSFES 469
Query: 160 ALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTE 219
L+LA+ GG+ ++ LL+ER + + G TPL+ A R H + V LL +GA++ +
Sbjct: 470 PLTLAACGGHVELAALLIERGASLEEVNDEGYTPLMEAAREGHEEMVALLLGQGANINAQ 529
Query: 220 A-DSGYTPMDLAVALGYRKV 238
++ T + LA G+ +V
Sbjct: 530 TEETQETALTLACCGGFLEV 549
Score = 69.3 bits (168), Expect = 3e-12
Identities = 51/184 (27%), Positives = 92/184 (50%), Gaps = 9/184 (4%)
Query: 79 GNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIE 138
G++++A T + ++ QG + + L + N+ ++ + G TPL+ A++ G E
Sbjct: 990 GSDINAQIETNRNTALTLACFQGRTEVVSLLLDRKANVEHRA-KTGLTPLMEAASGGYAE 1048
Query: 139 TVRFLLEWGADPHI--LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLY 196
R LL+ GAD + + R++AL++A+ G+ LL+ R I++ + G TPL
Sbjct: 1049 VGRVLLDKGADVNAPPVPSSRDTALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWL 1108
Query: 197 AVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVP 256
A G H+ V+ L+ GAD+ + TP+ A G+ KV + + + N P
Sbjct: 1109 AANGGHLDVVQLLVQAGADVDAADNRKITPLMAAFRKGHVKVVRYLVKEV------NQFP 1162
Query: 257 ADPE 260
+D E
Sbjct: 1163 SDSE 1166
Score = 67.4 bits (163), Expect = 1e-11
Identities = 44/143 (30%), Positives = 68/143 (47%)
Query: 96 QLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAK 155
+ + G ++ + L G + +E + L A G +E VRFLLE GAD
Sbjct: 373 EAGSAGHVEVARLLLENGAGINTHSNEFKESALTLACYKGHLEMVRFLLEAGADQEHKTD 432
Query: 156 ERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
E +AL A G+ ++ LLL+ +N+ + +PL A G HV+ L+ RGA
Sbjct: 433 EMHTALMEACMDGHVEVARLLLDSGAQVNMPADSFESPLTLAACGGHVELAALLIERGAS 492
Query: 216 LTTEADSGYTPMDLAVALGYRKV 238
L D GYTP+ A G+ ++
Sbjct: 493 LEEVNDEGYTPLMEAAREGHEEM 515
Score = 67.0 bits (162), Expect = 2e-11
Identities = 50/178 (28%), Positives = 90/178 (50%), Gaps = 3/178 (1%)
Query: 66 SLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGF 125
+L + R R E +A D+ S+ + ++G+++ +++ L +G + VN+ E G
Sbjct: 211 ALDEAAAALTRMRA-ESTANAGQSDNRSLAEACSEGDVNAVRKLLIEGRS-VNEHTEEGE 268
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERE-SALSLASTGGYTDIVGLLLERDVDIN 184
+ L A + G E + LL A+ + + + L A+ GG+ IV LLL D+N
Sbjct: 269 SLLCLACSAGYYELAQVLLAMHANVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVN 328
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
G T L YA G +V V+ LL GA + ++G+TP+ A + G+ +V +++
Sbjct: 329 AQSSTGNTALTYACAGGYVDVVKVLLESGASIEDHNENGHTPLMEAGSAGHVEVARLL 386
Score = 65.1 bits (157), Expect = 6e-11
Identities = 48/159 (30%), Positives = 81/159 (50%), Gaps = 5/159 (3%)
Query: 85 LPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLL 144
+PA + A G ++ + +G +L DE G+TPL+ A+ G E V LL
Sbjct: 462 MPADSFESPLTLAACGGHVELAALLIERGASLEEVNDE-GYTPLMEAAREGHEEMVALLL 520
Query: 145 EWGADPHILAKE-RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
GA+ + +E +E+AL+LA GG+ ++ L++ DI + TPL+ A + H+
Sbjct: 521 GQGANINAQTEETQETALTLACCGGFLEVADFLIKAGADIEL---GCSTPLMEAAQEGHL 577
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
+ V+ LLA GA++ +G T + A G+ V V+
Sbjct: 578 ELVKYLLAAGANVHATTATGDTALTYACENGHTDVADVL 616
Score = 65.1 bits (157), Expect = 6e-11
Identities = 73/299 (24%), Positives = 123/299 (41%), Gaps = 69/299 (23%)
Query: 2 ELTQPAEDLIQTQQTPASELG---DPEDPGEEAADGSDTVVL------------------ 40
+LT P+ DL + + P L P++P + A+ + T+ +
Sbjct: 733 QLTPPSHDLNRAPRVPVQALPMVVPPQEPDKPPANVATTLPIRNKAVSGRASAMSNTPTH 792
Query: 41 SLFPCTPEPVNPEPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQ 100
S+ +P P P + + SP A + + + + N +AL LA
Sbjct: 793 SIAASISQPQTPTP-SPIISPSAMLPIYPAIDIDAQTESNHDTALT----------LACA 841
Query: 101 GELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGAD----------- 149
G ++L + L + + D++GFTPLI A+ G + V LL+ GAD
Sbjct: 842 GGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEAQSERTKDT 901
Query: 150 PHILA------------------KERESA-----LSLASTGGYTDIVGLLLERDVDINIY 186
P LA KE + LSLA++GGY +I+ +LL +IN
Sbjct: 902 PLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLNAGAEINSR 961
Query: 187 DWN--GGTPLLYAVRGNHVKCVEALLARGADLTTEADSG-YTPMDLAVALGYRKVQQVI 242
+ G +PL+ A H V+ LL G+D+ + ++ T + LA G +V ++
Sbjct: 962 TGSKLGISPLMLAAMNGHTAAVKLLLDMGSDINAQIETNRNTALTLACFQGRTEVVSLL 1020
Score = 63.9 bits (154), Expect = 1e-10
Identities = 36/107 (33%), Positives = 58/107 (54%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
N+ ++ + TPL+ A+ G ++ V+ LL AD + + +AL+ A GGY D+V
Sbjct: 292 NVEDRGIKGDITPLMAAANGGHVKIVKLLLAHKADVNAQSSTGNTALTYACAGGYVDVVK 351
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEAD 221
+LLE I ++ NG TPL+ A HV+ LL GA + T ++
Sbjct: 352 VLLESGASIEDHNENGHTPLMEAGSAGHVEVARLLLENGAGINTHSN 398
Score = 63.9 bits (154), Expect = 1e-10
Identities = 45/120 (37%), Positives = 62/120 (51%), Gaps = 1/120 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T L A A G E V+ LLE GA K+ + L LA+T G+ +V +LL+ DI
Sbjct: 834 TALTLACAGGHEELVQTLLERGASIEHRDKKGFTPLILAATAGHVGVVEILLDNGADIEA 893
Query: 186 Y-DWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
+ TPL A G + VE LLARGA+ S YTP+ LA + GY + +++ N
Sbjct: 894 QSERTKDTPLSLACSGGRQEVVELLLARGANKEHRNVSDYTPLSLAASGGYVNIIKILLN 953
Score = 55.8 bits (133), Expect = 4e-08
Identities = 47/170 (27%), Positives = 77/170 (45%), Gaps = 9/170 (5%)
Query: 75 NRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAF 134
N + G+++ P L +++ H A + LD G ++ + + T L A
Sbjct: 959 NSRTGSKLGISPLMLAAMNGHTAAVKLLLDM-------GSDINAQIETNRNTALTLACFQ 1011
Query: 135 GEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI--YDWNGGT 192
G E V LL+ A+ AK + L A++GGY ++ +LL++ D+N + T
Sbjct: 1012 GRTEVVSLLLDRKANVEHRAKTGLTPLMEAASGGYAEVGRVLLDKGADVNAPPVPSSRDT 1071
Query: 193 PLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
L A H K E L+ RGA + G TP+ LA G+ V Q++
Sbjct: 1072 ALTIAADKGHYKFCELLIGRGAHIDVRNKKGNTPLWLAANGGHLDVVQLL 1121
Score = 53.1 bits (126), Expect = 2e-07
Identities = 45/133 (33%), Positives = 65/133 (48%), Gaps = 3/133 (2%)
Query: 79 GNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIE 138
G V A AT D+ ++ G D L+ G +L ++ E G TPL+ A+ G +
Sbjct: 587 GANVHATTATGDT-ALTYACENGHTDVADVLLQAGADLEHE-SEGGRTPLMKAARAGHVC 644
Query: 139 TVRFLLEWGADPH-ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
TV+FL+ GA+ + A + LSLA GG+ +V LLL D +G T L+ A
Sbjct: 645 TVQFLISKGANVNRTTANNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEA 704
Query: 198 VRGNHVKCVEALL 210
+G H V LL
Sbjct: 705 AKGGHTSVVCYLL 717
Score = 38.5 bits (88), Expect = 0.006
Identities = 33/117 (28%), Positives = 49/117 (41%), Gaps = 16/117 (13%)
Query: 62 QAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPD 121
QAG+ L+H + G + A A G + ++ + KG N+
Sbjct: 618 QAGADLEHES------EGGRTPLMKA----------ARAGHVCTVQFLISKGANVNRTTA 661
Query: 122 ERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLE 178
T L A A G + V LL GADP K+ + L A+ GG+T +V LL+
Sbjct: 662 NNDHTVLSLACAGGHLAVVELLLAHGADPTHRLKDGSTMLIEAAKGGHTSVVCYLLD 718
>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
Length = 1897
Score = 73.9 bits (180), Expect = 1e-13
Identities = 61/231 (26%), Positives = 95/231 (41%), Gaps = 1/231 (0%)
Query: 8 EDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSL 67
++L+Q +P E P AA T V VN + + + +
Sbjct: 454 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 513
Query: 68 KHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTP 127
H+ + N L T +H A +G ++ + L K + ++GFTP
Sbjct: 514 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTP 572
Query: 128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYD 187
L A+ +G++ LLE A P+ K + L +A DIV LLL R +
Sbjct: 573 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 632
Query: 188 WNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
WNG TPL A + N V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 633 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 683
Score = 73.2 bits (178), Expect = 2e-13
Identities = 51/171 (29%), Positives = 83/171 (48%), Gaps = 5/171 (2%)
Query: 75 NRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAF 134
NR R + A AT S + A G LD+ +HLR G + +N ++ G L AS
Sbjct: 34 NRSRDRKKKADAAT----SFLRAARSGNLDKALDHLRNGVD-INTCNQNGLNGLHLASKE 88
Query: 135 GEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPL 194
G ++ V LL K+ +AL +A+ G ++V L+ ++N G TPL
Sbjct: 89 GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPL 148
Query: 195 LYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A + NH++ V+ LL GA+ + G+TP+ +A+ G+ V + N+
Sbjct: 149 YMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINY 199
Score = 70.5 bits (171), Expect = 1e-12
Identities = 47/149 (31%), Positives = 79/149 (53%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + G L +K L++G + N + + TPL A+ G E ++LL+ A +
Sbjct: 441 LHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 499
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK+ ++ L A+ G+T++V LLLE + + N+ G TPL A R HV+ V ALL +
Sbjct: 500 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 559
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A G+TP+ +A G +V +++
Sbjct: 560 ASQACMTKKGFTPLHVAAKYGKVRVAELL 588
Score = 66.6 bits (161), Expect = 2e-11
Identities = 42/152 (27%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H LD +K L +G + + P G+TPL A+ ++E R LL++G +
Sbjct: 606 LHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 664
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + + L LA+ G+ ++V LLL + + N+ + +G TPL + HV + L+ G
Sbjct: 665 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 724
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
+ GYTP+ +A G K+ + + H
Sbjct: 725 VMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756
Score = 65.9 bits (159), Expect = 3e-11
Identities = 40/131 (30%), Positives = 66/131 (50%)
Query: 105 QLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
++ E L K ++ E G TPL AS G + V+ LL+ GA P++ + E+ L +A
Sbjct: 418 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 477
Query: 165 STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 224
+ G+T++ LL+ +N + TPL A R H V+ LL A+ +G+
Sbjct: 478 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 537
Query: 225 TPMDLAVALGY 235
TP+ +A G+
Sbjct: 538 TPLHIAAREGH 548
Score = 65.1 bits (157), Expect = 6e-11
Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A L+ + L +G + VN + G TPL AS G + VR LL+ GA
Sbjct: 243 LHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 301
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K+ + L A+ G+ I +LL+ I NG +P+ A +G+H+ CV LL
Sbjct: 302 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 361
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A++ TP+ +A G+ +V +V+
Sbjct: 362 AEIDDITLDHLTPLHVAAHCGHHRVAKVL 390
Score = 63.5 bits (153), Expect = 2e-10
Identities = 41/148 (27%), Positives = 74/148 (50%)
Query: 88 TLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 147
T D L+ AA+ ++ E L + + G +P+ A+ ++ VR LL++
Sbjct: 302 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 361
Query: 148 ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVE 207
A+ + + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E
Sbjct: 362 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 421
Query: 208 ALLARGADLTTEADSGYTPMDLAVALGY 235
LL GA + +SG TP+ +A +G+
Sbjct: 422 LLLKTGASIDAVTESGLTPLHVASFMGH 449
Score = 61.6 bits (148), Expect = 7e-10
Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 30/171 (17%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+ + ++E + G N VN ++GFTPL A+ +E V+FLLE GA+ ++
Sbjct: 114 ALHIAALAGQDEVVRELVNYGAN-VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 172
Query: 153 LAKERESALSLASTGGYTDIVG-----------------------------LLLERDVDI 183
++ + L++A G+ ++V +LL+ D +
Sbjct: 173 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 232
Query: 184 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
++ G TPL A ++ + LL RGA + +G TP+ +A G
Sbjct: 233 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 283
Score = 60.1 bits (144), Expect = 2e-09
Identities = 40/149 (26%), Positives = 73/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + +G + ++ L +G + K + TPL A+ G + LL+ GA
Sbjct: 276 LHIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAK 334
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +G
Sbjct: 335 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 394
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A + A +G+TP+ +A + +V +++
Sbjct: 395 AKPNSRALNGFTPLHIACKKNHVRVMELL 423
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 30/181 (16%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA----- 148
++ A + L+ +K L G N N E GFTPL A G V L+ +G
Sbjct: 148 LYMAAQENHLEVVKFLLENGANQ-NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 206
Query: 149 ------------------------DPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
+P +L+K + L +A+ ++ LLL R +N
Sbjct: 207 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 266
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
NG TPL A R +V V LL RGA + T+ TP+ A G+ ++ +++ +
Sbjct: 267 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 326
Query: 245 H 245
H
Sbjct: 327 H 327
Score = 58.9 bits (141), Expect = 4e-09
Identities = 51/163 (31%), Positives = 76/163 (46%), Gaps = 9/163 (5%)
Query: 88 TLDSLS-IHQLAAQGELDQLKEHLRKGDNLVNKPDER---GFTPLIWASAFGEIETVRFL 143
TLD L+ +H A G K L KG KP+ R GFTPL A + + L
Sbjct: 368 TLDHLTPLHVAAHCGHHRVAKVLLDKGA----KPNSRALNGFTPLHIACKKNHVRVMELL 423
Query: 144 LEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
L+ GA + + + L +AS G+ IV LL+R N+ + TPL A R H
Sbjct: 424 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 483
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGY-RKVQQVIENH 245
+ + LL A + +A TP+ A +G+ V+ ++EN+
Sbjct: 484 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 526
Score = 58.9 bits (141), Expect = 4e-09
Identities = 40/116 (34%), Positives = 61/116 (52%), Gaps = 1/116 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H +A +G + + + L K +V+ G+TPL AS +G I+ V+FLL+ AD +
Sbjct: 705 LHLVAQEGHVP-VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 763
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 209
K S L A+ G+TDIV LLL+ N +G TPL A R ++ + L
Sbjct: 764 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 819
Score = 56.6 bits (135), Expect = 2e-08
Identities = 43/152 (28%), Positives = 67/152 (44%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G++ ++ E L + D N + G TPL A ++ V+ LL G PH
Sbjct: 573 LHVAAKYGKV-RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 631
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
A + L +A+ ++ LL+ N G TPL A + H + V LL++
Sbjct: 632 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 691
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A+ SG TP+ L G+ V V+ H
Sbjct: 692 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 723
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 71/153 (46%), Gaps = 1/153 (0%)
Query: 86 PATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLE 145
PA +H A Q +++ + L+ G + N +G TPL A+ G E V LL
Sbjct: 631 PAWNGYTPLHIAAKQNQVEVARSLLQYGGS-ANAESVQGVTPLHLAAQEGHAEMVALLLS 689
Query: 146 WGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC 205
A+ ++ K + L L + G+ + +L++ V ++ G TPL A ++K
Sbjct: 690 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 749
Query: 206 VEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
V+ LL AD+ + GY+P+ A G+ +
Sbjct: 750 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 782
Score = 56.2 bits (134), Expect = 3e-08
Identities = 42/150 (28%), Positives = 65/150 (43%), Gaps = 1/150 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A +G + + L K N N ++ G TPL + G + L++ G
Sbjct: 672 LHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 730
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + L +AS G +V LL+ D+N G +PL A + H V LL G
Sbjct: 731 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 790
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
A + G TP+ +A LGY V V++
Sbjct: 791 ASPNEVSSDGTTPLAIAKRLGYISVTDVLK 820
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/134 (29%), Positives = 64/134 (47%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
+AA+ + + L + D + + GFTPL A+ + + + LL GA + +
Sbjct: 212 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 271
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L +AS G +V LLL+R I + TPL A R HV+ E LL GA +
Sbjct: 272 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 331
Query: 217 TTEADSGYTPMDLA 230
+ +G +P+ +A
Sbjct: 332 QAKTKNGLSPIHMA 345
Score = 48.5 bits (114), Expect = 6e-06
Identities = 40/160 (25%), Positives = 80/160 (50%), Gaps = 4/160 (2%)
Query: 55 DASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLS-IHQLAAQGELDQLKEHLRKG 113
DA+ S +A S L + + G +++ + L+ +H + +G + + E L K
Sbjct: 44 DAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLHK- 100
Query: 114 DNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIV 173
+ ++ ++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + ++V
Sbjct: 101 EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVV 160
Query: 174 GLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
LLE + N+ +G TPL A++ H V L+ G
Sbjct: 161 KFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 200
>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
Length = 1881
Score = 73.9 bits (180), Expect = 1e-13
Identities = 61/231 (26%), Positives = 95/231 (41%), Gaps = 1/231 (0%)
Query: 8 EDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSL 67
++L+Q +P E P AA T V VN + + + +
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 68 KHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTP 127
H+ + N L T +H A +G ++ + L K + ++GFTP
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTP 539
Query: 128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYD 187
L A+ +G++ LLE A P+ K + L +A DIV LLL R +
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 188 WNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
WNG TPL A + N V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Score = 70.5 bits (171), Expect = 1e-12
Identities = 45/153 (29%), Positives = 76/153 (49%), Gaps = 1/153 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
S + A G LD+ +HLR G + +N ++ G L AS G ++ V LL
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K+ +AL +A+ G ++V L+ ++N G TPL A + NH++ V+ LL
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
GA+ + G+TP+ +A+ G+ V + N+
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 70.5 bits (171), Expect = 1e-12
Identities = 47/149 (31%), Positives = 79/149 (53%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + G L +K L++G + N + + TPL A+ G E ++LL+ A +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK+ ++ L A+ G+T++V LLLE + + N+ G TPL A R HV+ V ALL +
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A G+TP+ +A G +V +++
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 66.6 bits (161), Expect = 2e-11
Identities = 42/152 (27%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H LD +K L +G + + P G+TPL A+ ++E R LL++G +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + + L LA+ G+ ++V LLL + + N+ + +G TPL + HV + L+ G
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
+ GYTP+ +A G K+ + + H
Sbjct: 692 VMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Score = 65.9 bits (159), Expect = 3e-11
Identities = 40/131 (30%), Positives = 66/131 (50%)
Query: 105 QLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
++ E L K ++ E G TPL AS G + V+ LL+ GA P++ + E+ L +A
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 165 STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 224
+ G+T++ LL+ +N + TPL A R H V+ LL A+ +G+
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
Query: 225 TPMDLAVALGY 235
TP+ +A G+
Sbjct: 505 TPLHIAAREGH 515
Score = 65.1 bits (157), Expect = 6e-11
Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A L+ + L +G + VN + G TPL AS G + VR LL+ GA
Sbjct: 210 LHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K+ + L A+ G+ I +LL+ I NG +P+ A +G+H+ CV LL
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A++ TP+ +A G+ +V +V+
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 63.5 bits (153), Expect = 2e-10
Identities = 41/148 (27%), Positives = 74/148 (50%)
Query: 88 TLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 147
T D L+ AA+ ++ E L + + G +P+ A+ ++ VR LL++
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 148 ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVE 207
A+ + + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
Query: 208 ALLARGADLTTEADSGYTPMDLAVALGY 235
LL GA + +SG TP+ +A +G+
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 61.6 bits (148), Expect = 7e-10
Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 30/171 (17%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+ + ++E + G N VN ++GFTPL A+ +E V+FLLE GA+ ++
Sbjct: 81 ALHIAALAGQDEVVRELVNYGAN-VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 153 LAKERESALSLASTGGYTDIVG-----------------------------LLLERDVDI 183
++ + L++A G+ ++V +LL+ D +
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 184 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
++ G TPL A ++ + LL RGA + +G TP+ +A G
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Score = 60.1 bits (144), Expect = 2e-09
Identities = 40/149 (26%), Positives = 73/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + +G + ++ L +G + K + TPL A+ G + LL+ GA
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +G
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A + A +G+TP+ +A + +V +++
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 30/181 (16%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA----- 148
++ A + L+ +K L G N N E GFTPL A G V L+ +G
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQ-NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 149 ------------------------DPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
+P +L+K + L +A+ ++ LLL R +N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
NG TPL A R +V V LL RGA + T+ TP+ A G+ ++ +++ +
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 245 H 245
H
Sbjct: 294 H 294
Score = 58.9 bits (141), Expect = 4e-09
Identities = 51/163 (31%), Positives = 76/163 (46%), Gaps = 9/163 (5%)
Query: 88 TLDSLS-IHQLAAQGELDQLKEHLRKGDNLVNKPDER---GFTPLIWASAFGEIETVRFL 143
TLD L+ +H A G K L KG KP+ R GFTPL A + + L
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGA----KPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 144 LEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
L+ GA + + + L +AS G+ IV LL+R N+ + TPL A R H
Sbjct: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGY-RKVQQVIENH 245
+ + LL A + +A TP+ A +G+ V+ ++EN+
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Score = 58.9 bits (141), Expect = 4e-09
Identities = 40/116 (34%), Positives = 61/116 (52%), Gaps = 1/116 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H +A +G + + + L K +V+ G+TPL AS +G I+ V+FLL+ AD +
Sbjct: 672 LHLVAQEGHVP-VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 209
K S L A+ G+TDIV LLL+ N +G TPL A R ++ + L
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 56.6 bits (135), Expect = 2e-08
Identities = 43/152 (28%), Positives = 67/152 (44%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G++ ++ E L + D N + G TPL A ++ V+ LL G PH
Sbjct: 540 LHVAAKYGKV-RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
A + L +A+ ++ LL+ N G TPL A + H + V LL++
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A+ SG TP+ L G+ V V+ H
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 71/153 (46%), Gaps = 1/153 (0%)
Query: 86 PATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLE 145
PA +H A Q +++ + L+ G + N +G TPL A+ G E V LL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGS-ANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 146 WGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC 205
A+ ++ K + L L + G+ + +L++ V ++ G TPL A ++K
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 206 VEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
V+ LL AD+ + GY+P+ A G+ +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 56.2 bits (134), Expect = 3e-08
Identities = 42/150 (28%), Positives = 65/150 (43%), Gaps = 1/150 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A +G + + L K N N ++ G TPL + G + L++ G
Sbjct: 639 LHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + L +AS G +V LL+ D+N G +PL A + H V LL G
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
A + G TP+ +A LGY V V++
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/134 (29%), Positives = 64/134 (47%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
+AA+ + + L + D + + GFTPL A+ + + + LL GA + +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L +AS G +V LLL+R I + TPL A R HV+ E LL GA +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 217 TTEADSGYTPMDLA 230
+ +G +P+ +A
Sbjct: 299 QAKTKNGLSPIHMA 312
Score = 50.1 bits (118), Expect = 2e-06
Identities = 41/162 (25%), Positives = 81/162 (50%), Gaps = 4/162 (2%)
Query: 53 EPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLS-IHQLAAQGELDQLKEHLR 111
E DA+ S +A S L + + G +++ + L+ +H + +G + + E L
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 112 KGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTD 171
K + ++ ++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + +
Sbjct: 67 K-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 172 IVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+V LLE + N+ +G TPL A++ H V L+ G
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 244
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
Length = 1880
Score = 73.9 bits (180), Expect = 1e-13
Identities = 61/231 (26%), Positives = 95/231 (41%), Gaps = 1/231 (0%)
Query: 8 EDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSL 67
++L+Q +P E P AA T V VN + + + +
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 68 KHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTP 127
H+ + N L T +H A +G ++ + L K + ++GFTP
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTP 539
Query: 128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYD 187
L A+ +G++ LLE A P+ K + L +A DIV LLL R +
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 188 WNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
WNG TPL A + N V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Score = 70.5 bits (171), Expect = 1e-12
Identities = 45/153 (29%), Positives = 76/153 (49%), Gaps = 1/153 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
S + A G LD+ +HLR G + +N ++ G L AS G ++ V LL
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K+ +AL +A+ G ++V L+ ++N G TPL A + NH++ V+ LL
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
GA+ + G+TP+ +A+ G+ V + N+
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 70.5 bits (171), Expect = 1e-12
Identities = 47/149 (31%), Positives = 79/149 (53%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + G L +K L++G + N + + TPL A+ G E ++LL+ A +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK+ ++ L A+ G+T++V LLLE + + N+ G TPL A R HV+ V ALL +
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A G+TP+ +A G +V +++
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 66.6 bits (161), Expect = 2e-11
Identities = 42/152 (27%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H LD +K L +G + + P G+TPL A+ ++E R LL++G +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + + L LA+ G+ ++V LLL + + N+ + +G TPL + HV + L+ G
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
+ GYTP+ +A G K+ + + H
Sbjct: 692 VMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Score = 65.9 bits (159), Expect = 3e-11
Identities = 40/131 (30%), Positives = 66/131 (50%)
Query: 105 QLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
++ E L K ++ E G TPL AS G + V+ LL+ GA P++ + E+ L +A
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 165 STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 224
+ G+T++ LL+ +N + TPL A R H V+ LL A+ +G+
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
Query: 225 TPMDLAVALGY 235
TP+ +A G+
Sbjct: 505 TPLHIAAREGH 515
Score = 65.1 bits (157), Expect = 6e-11
Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A L+ + L +G + VN + G TPL AS G + VR LL+ GA
Sbjct: 210 LHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K+ + L A+ G+ I +LL+ I NG +P+ A +G+H+ CV LL
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A++ TP+ +A G+ +V +V+
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 63.5 bits (153), Expect = 2e-10
Identities = 41/148 (27%), Positives = 74/148 (50%)
Query: 88 TLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 147
T D L+ AA+ ++ E L + + G +P+ A+ ++ VR LL++
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 148 ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVE 207
A+ + + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
Query: 208 ALLARGADLTTEADSGYTPMDLAVALGY 235
LL GA + +SG TP+ +A +G+
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 61.6 bits (148), Expect = 7e-10
Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 30/171 (17%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+ + ++E + G N VN ++GFTPL A+ +E V+FLLE GA+ ++
Sbjct: 81 ALHIAALAGQDEVVRELVNYGAN-VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 153 LAKERESALSLASTGGYTDIVG-----------------------------LLLERDVDI 183
++ + L++A G+ ++V +LL+ D +
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 184 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
++ G TPL A ++ + LL RGA + +G TP+ +A G
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Score = 60.1 bits (144), Expect = 2e-09
Identities = 40/149 (26%), Positives = 73/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + +G + ++ L +G + K + TPL A+ G + LL+ GA
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +G
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A + A +G+TP+ +A + +V +++
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 30/181 (16%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA----- 148
++ A + L+ +K L G N N E GFTPL A G V L+ +G
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQ-NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 149 ------------------------DPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
+P +L+K + L +A+ ++ LLL R +N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
NG TPL A R +V V LL RGA + T+ TP+ A G+ ++ +++ +
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 245 H 245
H
Sbjct: 294 H 294
Score = 58.9 bits (141), Expect = 4e-09
Identities = 51/163 (31%), Positives = 76/163 (46%), Gaps = 9/163 (5%)
Query: 88 TLDSLS-IHQLAAQGELDQLKEHLRKGDNLVNKPDER---GFTPLIWASAFGEIETVRFL 143
TLD L+ +H A G K L KG KP+ R GFTPL A + + L
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGA----KPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 144 LEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
L+ GA + + + L +AS G+ IV LL+R N+ + TPL A R H
Sbjct: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGY-RKVQQVIENH 245
+ + LL A + +A TP+ A +G+ V+ ++EN+
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Score = 58.9 bits (141), Expect = 4e-09
Identities = 40/116 (34%), Positives = 61/116 (52%), Gaps = 1/116 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H +A +G + + + L K +V+ G+TPL AS +G I+ V+FLL+ AD +
Sbjct: 672 LHLVAQEGHVP-VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 209
K S L A+ G+TDIV LLL+ N +G TPL A R ++ + L
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 56.6 bits (135), Expect = 2e-08
Identities = 43/152 (28%), Positives = 67/152 (44%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G++ ++ E L + D N + G TPL A ++ V+ LL G PH
Sbjct: 540 LHVAAKYGKV-RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
A + L +A+ ++ LL+ N G TPL A + H + V LL++
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A+ SG TP+ L G+ V V+ H
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 71/153 (46%), Gaps = 1/153 (0%)
Query: 86 PATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLE 145
PA +H A Q +++ + L+ G + N +G TPL A+ G E V LL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGS-ANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 146 WGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC 205
A+ ++ K + L L + G+ + +L++ V ++ G TPL A ++K
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 206 VEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
V+ LL AD+ + GY+P+ A G+ +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 56.2 bits (134), Expect = 3e-08
Identities = 42/150 (28%), Positives = 65/150 (43%), Gaps = 1/150 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A +G + + L K N N ++ G TPL + G + L++ G
Sbjct: 639 LHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + L +AS G +V LL+ D+N G +PL A + H V LL G
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
A + G TP+ +A LGY V V++
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/134 (29%), Positives = 64/134 (47%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
+AA+ + + L + D + + GFTPL A+ + + + LL GA + +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L +AS G +V LLL+R I + TPL A R HV+ E LL GA +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 217 TTEADSGYTPMDLA 230
+ +G +P+ +A
Sbjct: 299 QAKTKNGLSPIHMA 312
Score = 50.1 bits (118), Expect = 2e-06
Identities = 41/162 (25%), Positives = 81/162 (50%), Gaps = 4/162 (2%)
Query: 53 EPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLS-IHQLAAQGELDQLKEHLR 111
E DA+ S +A S L + + G +++ + L+ +H + +G + + E L
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 112 KGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTD 171
K + ++ ++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + +
Sbjct: 67 K-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 172 IVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+V LLE + N+ +G TPL A++ H V L+ G
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 244
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
Length = 1719
Score = 73.9 bits (180), Expect = 1e-13
Identities = 61/231 (26%), Positives = 95/231 (41%), Gaps = 1/231 (0%)
Query: 8 EDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSL 67
++L+Q +P E P AA T V VN + + + +
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 68 KHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTP 127
H+ + N L T +H A +G ++ + L K + ++GFTP
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTP 539
Query: 128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYD 187
L A+ +G++ LLE A P+ K + L +A DIV LLL R +
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 188 WNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
WNG TPL A + N V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Score = 70.5 bits (171), Expect = 1e-12
Identities = 45/153 (29%), Positives = 76/153 (49%), Gaps = 1/153 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
S + A G LD+ +HLR G + +N ++ G L AS G ++ V LL
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K+ +AL +A+ G ++V L+ ++N G TPL A + NH++ V+ LL
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
GA+ + G+TP+ +A+ G+ V + N+
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 70.5 bits (171), Expect = 1e-12
Identities = 47/149 (31%), Positives = 79/149 (53%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + G L +K L++G + N + + TPL A+ G E ++LL+ A +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK+ ++ L A+ G+T++V LLLE + + N+ G TPL A R HV+ V ALL +
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A G+TP+ +A G +V +++
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 66.6 bits (161), Expect = 2e-11
Identities = 42/152 (27%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H LD +K L +G + + P G+TPL A+ ++E R LL++G +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + + L LA+ G+ ++V LLL + + N+ + +G TPL + HV + L+ G
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
+ GYTP+ +A G K+ + + H
Sbjct: 692 VMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Score = 65.9 bits (159), Expect = 3e-11
Identities = 40/131 (30%), Positives = 66/131 (50%)
Query: 105 QLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
++ E L K ++ E G TPL AS G + V+ LL+ GA P++ + E+ L +A
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 165 STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 224
+ G+T++ LL+ +N + TPL A R H V+ LL A+ +G+
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
Query: 225 TPMDLAVALGY 235
TP+ +A G+
Sbjct: 505 TPLHIAAREGH 515
Score = 65.1 bits (157), Expect = 6e-11
Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A L+ + L +G + VN + G TPL AS G + VR LL+ GA
Sbjct: 210 LHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K+ + L A+ G+ I +LL+ I NG +P+ A +G+H+ CV LL
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A++ TP+ +A G+ +V +V+
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 63.5 bits (153), Expect = 2e-10
Identities = 41/148 (27%), Positives = 74/148 (50%)
Query: 88 TLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 147
T D L+ AA+ ++ E L + + G +P+ A+ ++ VR LL++
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 148 ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVE 207
A+ + + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
Query: 208 ALLARGADLTTEADSGYTPMDLAVALGY 235
LL GA + +SG TP+ +A +G+
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 61.6 bits (148), Expect = 7e-10
Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 30/171 (17%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+ + ++E + G N VN ++GFTPL A+ +E V+FLLE GA+ ++
Sbjct: 81 ALHIAALAGQDEVVRELVNYGAN-VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 153 LAKERESALSLASTGGYTDIVG-----------------------------LLLERDVDI 183
++ + L++A G+ ++V +LL+ D +
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 184 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
++ G TPL A ++ + LL RGA + +G TP+ +A G
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Score = 60.1 bits (144), Expect = 2e-09
Identities = 40/149 (26%), Positives = 73/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + +G + ++ L +G + K + TPL A+ G + LL+ GA
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +G
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A + A +G+TP+ +A + +V +++
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 30/181 (16%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA----- 148
++ A + L+ +K L G N N E GFTPL A G V L+ +G
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQ-NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 149 ------------------------DPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
+P +L+K + L +A+ ++ LLL R +N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
NG TPL A R +V V LL RGA + T+ TP+ A G+ ++ +++ +
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 245 H 245
H
Sbjct: 294 H 294
Score = 58.9 bits (141), Expect = 4e-09
Identities = 51/163 (31%), Positives = 76/163 (46%), Gaps = 9/163 (5%)
Query: 88 TLDSLS-IHQLAAQGELDQLKEHLRKGDNLVNKPDER---GFTPLIWASAFGEIETVRFL 143
TLD L+ +H A G K L KG KP+ R GFTPL A + + L
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGA----KPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 144 LEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
L+ GA + + + L +AS G+ IV LL+R N+ + TPL A R H
Sbjct: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGY-RKVQQVIENH 245
+ + LL A + +A TP+ A +G+ V+ ++EN+
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Score = 58.9 bits (141), Expect = 4e-09
Identities = 40/116 (34%), Positives = 61/116 (52%), Gaps = 1/116 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H +A +G + + + L K +V+ G+TPL AS +G I+ V+FLL+ AD +
Sbjct: 672 LHLVAQEGHVP-VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 209
K S L A+ G+TDIV LLL+ N +G TPL A R ++ + L
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 56.6 bits (135), Expect = 2e-08
Identities = 43/152 (28%), Positives = 67/152 (44%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G++ ++ E L + D N + G TPL A ++ V+ LL G PH
Sbjct: 540 LHVAAKYGKV-RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
A + L +A+ ++ LL+ N G TPL A + H + V LL++
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A+ SG TP+ L G+ V V+ H
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 71/153 (46%), Gaps = 1/153 (0%)
Query: 86 PATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLE 145
PA +H A Q +++ + L+ G + N +G TPL A+ G E V LL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGS-ANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 146 WGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC 205
A+ ++ K + L L + G+ + +L++ V ++ G TPL A ++K
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 206 VEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
V+ LL AD+ + GY+P+ A G+ +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 56.2 bits (134), Expect = 3e-08
Identities = 42/150 (28%), Positives = 65/150 (43%), Gaps = 1/150 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A +G + + L K N N ++ G TPL + G + L++ G
Sbjct: 639 LHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + L +AS G +V LL+ D+N G +PL A + H V LL G
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
A + G TP+ +A LGY V V++
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/134 (29%), Positives = 64/134 (47%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
+AA+ + + L + D + + GFTPL A+ + + + LL GA + +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L +AS G +V LLL+R I + TPL A R HV+ E LL GA +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 217 TTEADSGYTPMDLA 230
+ +G +P+ +A
Sbjct: 299 QAKTKNGLSPIHMA 312
Score = 50.1 bits (118), Expect = 2e-06
Identities = 41/162 (25%), Positives = 81/162 (50%), Gaps = 4/162 (2%)
Query: 53 EPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLS-IHQLAAQGELDQLKEHLR 111
E DA+ S +A S L + + G +++ + L+ +H + +G + + E L
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 112 KGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTD 171
K + ++ ++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + +
Sbjct: 67 K-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 172 IVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+V LLE + N+ +G TPL A++ H V L+ G
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 244
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
Length = 1856
Score = 73.9 bits (180), Expect = 1e-13
Identities = 61/231 (26%), Positives = 95/231 (41%), Gaps = 1/231 (0%)
Query: 8 EDLIQTQQTPASELGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSL 67
++L+Q +P E P AA T V VN + + + +
Sbjct: 421 KNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARI 480
Query: 68 KHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTP 127
H+ + N L T +H A +G ++ + L K + ++GFTP
Sbjct: 481 GHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMT-KKGFTP 539
Query: 128 LIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYD 187
L A+ +G++ LLE A P+ K + L +A DIV LLL R +
Sbjct: 540 LHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPA 599
Query: 188 WNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
WNG TPL A + N V+ +LL G E+ G TP+ LA G+ ++
Sbjct: 600 WNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEM 650
Score = 70.5 bits (171), Expect = 1e-12
Identities = 45/153 (29%), Positives = 76/153 (49%), Gaps = 1/153 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
S + A G LD+ +HLR G + +N ++ G L AS G ++ V LL
Sbjct: 15 SFLRAARSGNLDKALDHLRNGVD-INTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K+ +AL +A+ G ++V L+ ++N G TPL A + NH++ V+ LL
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
Query: 213 GADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
GA+ + G+TP+ +A+ G+ V + N+
Sbjct: 134 GANQNVATEDGFTPLAVALQQGHENVVAHLINY 166
Score = 70.5 bits (171), Expect = 1e-12
Identities = 47/149 (31%), Positives = 79/149 (53%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + G L +K L++G + N + + TPL A+ G E ++LL+ A +
Sbjct: 408 LHVASFMGHLPIVKNLLQRGAS-PNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAK 466
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
AK+ ++ L A+ G+T++V LLLE + + N+ G TPL A R HV+ V ALL +
Sbjct: 467 AKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEKE 526
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A G+TP+ +A G +V +++
Sbjct: 527 ASQACMTKKGFTPLHVAAKYGKVRVAELL 555
Score = 66.6 bits (161), Expect = 2e-11
Identities = 42/152 (27%), Positives = 75/152 (49%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H LD +K L +G + + P G+TPL A+ ++E R LL++G +
Sbjct: 573 LHVAVHHNNLDIVKLLLPRGGS-PHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSANAE 631
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + + L LA+ G+ ++V LLL + + N+ + +G TPL + HV + L+ G
Sbjct: 632 SVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHG 691
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
+ GYTP+ +A G K+ + + H
Sbjct: 692 VMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723
Score = 65.9 bits (159), Expect = 3e-11
Identities = 40/131 (30%), Positives = 66/131 (50%)
Query: 105 QLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLA 164
++ E L K ++ E G TPL AS G + V+ LL+ GA P++ + E+ L +A
Sbjct: 385 RVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMA 444
Query: 165 STGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGY 224
+ G+T++ LL+ +N + TPL A R H V+ LL A+ +G+
Sbjct: 445 ARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGH 504
Query: 225 TPMDLAVALGY 235
TP+ +A G+
Sbjct: 505 TPLHIAAREGH 515
Score = 65.1 bits (157), Expect = 6e-11
Identities = 45/149 (30%), Positives = 72/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A L+ + L +G + VN + G TPL AS G + VR LL+ GA
Sbjct: 210 LHIAAHYENLNVAQLLLNRGAS-VNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETK 268
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K+ + L A+ G+ I +LL+ I NG +P+ A +G+H+ CV LL
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A++ TP+ +A G+ +V +V+
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVL 357
Score = 63.5 bits (153), Expect = 2e-10
Identities = 41/148 (27%), Positives = 74/148 (50%)
Query: 88 TLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 147
T D L+ AA+ ++ E L + + G +P+ A+ ++ VR LL++
Sbjct: 269 TKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYD 328
Query: 148 ADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVE 207
A+ + + + L +A+ G+ + +LL++ N NG TPL A + NHV+ +E
Sbjct: 329 AEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVME 388
Query: 208 ALLARGADLTTEADSGYTPMDLAVALGY 235
LL GA + +SG TP+ +A +G+
Sbjct: 389 LLLKTGASIDAVTESGLTPLHVASFMGH 416
Score = 61.6 bits (148), Expect = 7e-10
Identities = 44/171 (25%), Positives = 79/171 (46%), Gaps = 30/171 (17%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G+ + ++E + G N VN ++GFTPL A+ +E V+FLLE GA+ ++
Sbjct: 81 ALHIAALAGQDEVVRELVNYGAN-VNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQNV 139
Query: 153 LAKERESALSLASTGGYTDIVG-----------------------------LLLERDVDI 183
++ + L++A G+ ++V +LL+ D +
Sbjct: 140 ATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNP 199
Query: 184 NIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
++ G TPL A ++ + LL RGA + +G TP+ +A G
Sbjct: 200 DVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRG 250
Score = 60.1 bits (144), Expect = 2e-09
Identities = 40/149 (26%), Positives = 73/149 (48%), Gaps = 1/149 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H + +G + ++ L +G + K + TPL A+ G + LL+ GA
Sbjct: 243 LHIASRRGNVIMVRLLLDRGAQIETKTKDE-LTPLHCAARNGHVRISEILLDHGAPIQAK 301
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K S + +A+ G + D V LLL+ D +I+ + TPL A H + + LL +G
Sbjct: 302 TKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKG 361
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVI 242
A + A +G+TP+ +A + +V +++
Sbjct: 362 AKPNSRALNGFTPLHIACKKNHVRVMELL 390
Score = 59.3 bits (142), Expect = 3e-09
Identities = 48/181 (26%), Positives = 75/181 (41%), Gaps = 30/181 (16%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA----- 148
++ A + L+ +K L G N N E GFTPL A G V L+ +G
Sbjct: 115 LYMAAQENHLEVVKFLLENGANQ-NVATEDGFTPLAVALQQGHENVVAHLINYGTKGKVR 173
Query: 149 ------------------------DPHILAKERESALSLASTGGYTDIVGLLLERDVDIN 184
+P +L+K + L +A+ ++ LLL R +N
Sbjct: 174 LPALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVN 233
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
NG TPL A R +V V LL RGA + T+ TP+ A G+ ++ +++ +
Sbjct: 234 FTPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLD 293
Query: 245 H 245
H
Sbjct: 294 H 294
Score = 58.9 bits (141), Expect = 4e-09
Identities = 51/163 (31%), Positives = 76/163 (46%), Gaps = 9/163 (5%)
Query: 88 TLDSLS-IHQLAAQGELDQLKEHLRKGDNLVNKPDER---GFTPLIWASAFGEIETVRFL 143
TLD L+ +H A G K L KG KP+ R GFTPL A + + L
Sbjct: 335 TLDHLTPLHVAAHCGHHRVAKVLLDKGA----KPNSRALNGFTPLHIACKKNHVRVMELL 390
Query: 144 LEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHV 203
L+ GA + + + L +AS G+ IV LL+R N+ + TPL A R H
Sbjct: 391 LKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHT 450
Query: 204 KCVEALLARGADLTTEADSGYTPMDLAVALGY-RKVQQVIENH 245
+ + LL A + +A TP+ A +G+ V+ ++EN+
Sbjct: 451 EVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENN 493
Score = 58.9 bits (141), Expect = 4e-09
Identities = 40/116 (34%), Positives = 61/116 (52%), Gaps = 1/116 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H +A +G + + + L K +V+ G+TPL AS +G I+ V+FLL+ AD +
Sbjct: 672 LHLVAQEGHVP-VADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAK 730
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEAL 209
K S L A+ G+TDIV LLL+ N +G TPL A R ++ + L
Sbjct: 731 TKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAKRLGYISVTDVL 786
Score = 56.6 bits (135), Expect = 2e-08
Identities = 43/152 (28%), Positives = 67/152 (44%), Gaps = 1/152 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A G++ ++ E L + D N + G TPL A ++ V+ LL G PH
Sbjct: 540 LHVAAKYGKV-RVAELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSP 598
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
A + L +A+ ++ LL+ N G TPL A + H + V LL++
Sbjct: 599 AWNGYTPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQ 658
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
A+ SG TP+ L G+ V V+ H
Sbjct: 659 ANGNLGNKSGLTPLHLVAQEGHVPVADVLIKH 690
Score = 56.2 bits (134), Expect = 3e-08
Identities = 41/153 (26%), Positives = 71/153 (46%), Gaps = 1/153 (0%)
Query: 86 PATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLE 145
PA +H A Q +++ + L+ G + N +G TPL A+ G E V LL
Sbjct: 598 PAWNGYTPLHIAAKQNQVEVARSLLQYGGS-ANAESVQGVTPLHLAAQEGHAEMVALLLS 656
Query: 146 WGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKC 205
A+ ++ K + L L + G+ + +L++ V ++ G TPL A ++K
Sbjct: 657 KQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKL 716
Query: 206 VEALLARGADLTTEADSGYTPMDLAVALGYRKV 238
V+ LL AD+ + GY+P+ A G+ +
Sbjct: 717 VKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDI 749
Score = 56.2 bits (134), Expect = 3e-08
Identities = 42/150 (28%), Positives = 65/150 (43%), Gaps = 1/150 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A +G + + L K N N ++ G TPL + G + L++ G
Sbjct: 639 LHLAAQEGHAEMVALLLSKQAN-GNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDAT 697
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+ + L +AS G +V LL+ D+N G +PL A + H V LL G
Sbjct: 698 TRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNG 757
Query: 214 ADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
A + G TP+ +A LGY V V++
Sbjct: 758 ASPNEVSSDGTTPLAIAKRLGYISVTDVLK 787
Score = 55.8 bits (133), Expect = 4e-08
Identities = 39/134 (29%), Positives = 64/134 (47%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
+AA+ + + L + D + + GFTPL A+ + + + LL GA + +
Sbjct: 179 IAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQN 238
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L +AS G +V LLL+R I + TPL A R HV+ E LL GA +
Sbjct: 239 GITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPI 298
Query: 217 TTEADSGYTPMDLA 230
+ +G +P+ +A
Sbjct: 299 QAKTKNGLSPIHMA 312
Score = 50.1 bits (118), Expect = 2e-06
Identities = 41/162 (25%), Positives = 81/162 (50%), Gaps = 4/162 (2%)
Query: 53 EPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLS-IHQLAAQGELDQLKEHLR 111
E DA+ S +A S L + + G +++ + L+ +H + +G + + E L
Sbjct: 9 EADAATSFLRAARSGNLDKALDHLRNGVDINT--CNQNGLNGLHLASKEGHVKMVVELLH 66
Query: 112 KGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTD 171
K + ++ ++G T L A+ G+ E VR L+ +GA+ + +++ + L +A+ + +
Sbjct: 67 K-EIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLE 125
Query: 172 IVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+V LLE + N+ +G TPL A++ H V L+ G
Sbjct: 126 VVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167
Score = 39.3 bits (90), Expect = 0.003
Identities = 29/120 (24%), Positives = 56/120 (46%), Gaps = 1/120 (0%)
Query: 126 TPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
T + A+ G ++ L G D + + + L LAS G+ +V LL +++ +
Sbjct: 14 TSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILET 73
Query: 186 YDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQ-VIEN 244
G T L A + V L+ GA++ ++ G+TP+ +A + +V + ++EN
Sbjct: 74 TTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLEN 133
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 72.0 bits (175), Expect = 5e-13
Identities = 51/152 (33%), Positives = 79/152 (51%), Gaps = 4/152 (2%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
+AAQ + L L N+ DE G+ PL +A+ G+ T R LL+ GA +E
Sbjct: 401 IAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE 460
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L LA+ + ++ LL+ R D N+++ G TPL A HV V+ L ++GA+L
Sbjct: 461 GWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520
Query: 217 TTEADSGYTPMDLAVALGYRKVQQVIENHILK 248
+ + TP+ LAV G KV+ + H+LK
Sbjct: 521 DAQQRNLRTPLHLAVERG--KVRAI--QHLLK 548
Score = 64.7 bits (156), Expect = 8e-11
Identities = 50/169 (29%), Positives = 82/169 (48%), Gaps = 3/169 (1%)
Query: 78 RGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEI 137
+G E+ A L + +H +G++ + +HL K + + D+ G+ PL A+A G+
Sbjct: 516 QGAELDAQQRNLRT-PLHLAVERGKVRAI-QHLLKSGAVPDALDQSGYGPLHTAAARGKY 573
Query: 138 ETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYA 197
+ LL +GA + + + L LA+ G+ +I+ LL E ++ TPL A
Sbjct: 574 LICKMLLRYGASLELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLA 633
Query: 198 VRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG-YRKVQQVIENH 245
R V ALL GAD SG+TP+ LAV + V ++E+H
Sbjct: 634 ARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHH 682
Score = 60.5 bits (145), Expect = 1e-09
Identities = 51/162 (31%), Positives = 76/162 (46%), Gaps = 4/162 (2%)
Query: 84 ALPATLDSLS---IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETV 140
A+P LD +H AA+G+ K LR G +L P +G+TPL A+ G +E +
Sbjct: 551 AVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASL-ELPTHQGWTPLHLAAYKGHLEII 609
Query: 141 RFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRG 200
L E A+ L + L LA+ G +V LL+ D N + +G TPL AV+
Sbjct: 610 HLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAEQSGWTPLHLAVQR 669
Query: 201 NHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
+ V LL A++ G+TP LA G + +V+
Sbjct: 670 STFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVL 711
Score = 53.9 bits (128), Expect = 1e-07
Identities = 52/206 (25%), Positives = 83/206 (40%), Gaps = 8/206 (3%)
Query: 44 PCTPEPVNPEPDASVSSPQAGSSLKHSTTLTNRQRGNEVSALPATLDSLSIHQLAAQGEL 103
PC + + E D +S Q+ ++ S L + P ++ +L
Sbjct: 276 PCFLD-ITIETDILLSLLQSRVAVPESKALARKVSCKLSLRQPGEVNEDISQELMDSDSG 334
Query: 104 DQLKEHLRKGD--NLVNKPDE-----RGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
+ LK L+ D NLV + +E TPL + A G +E VR LL D
Sbjct: 335 NYLKRALQLSDRKNLVPRDEELCIYENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTAS 394
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L +A+ D+ LLL D N D +G PL +A + LL GA +
Sbjct: 395 GYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACV 454
Query: 217 TTEADSGYTPMDLAVALGYRKVQQVI 242
+ G+TP+ LA + V +++
Sbjct: 455 DAQEREGWTPLHLAAQNNFENVARLL 480
Score = 51.6 bits (122), Expect = 7e-07
Identities = 44/151 (29%), Positives = 68/151 (45%), Gaps = 3/151 (1%)
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
LAAQ + + L N + G TPL A+ FG + V+ L GA+ +
Sbjct: 467 LAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQRN 526
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPL-LYAVRGNHVKCVEALLARGAD 215
+ L LA G + LL+ + D +G PL A RG ++ C + LL GA
Sbjct: 527 LRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLIC-KMLLRYGAS 585
Query: 216 LTTEADSGYTPMDLAVALGYRKVQQVI-ENH 245
L G+TP+ LA G+ ++ ++ E+H
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESH 616
Score = 40.8 bits (94), Expect = 0.001
Identities = 24/78 (30%), Positives = 37/78 (47%)
Query: 168 GYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPM 227
G + V LLL +VD++ +G TPLL A + LLA GAD + G+ P+
Sbjct: 373 GSVEQVRLLLAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPL 432
Query: 228 DLAVALGYRKVQQVIENH 245
A G +++ +H
Sbjct: 433 HFAAQNGDDGTARLLLDH 450
Score = 37.0 bits (84), Expect = 0.017
Identities = 32/106 (30%), Positives = 50/106 (47%), Gaps = 1/106 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A GE + L+ G + N ++ G+TPL A +V LLE A+ H
Sbjct: 630 LHLAARHGEEAVVSALLQCGAD-PNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHAR 688
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVR 199
K + LA+ G T I+ +L+E +++ D TPL A+R
Sbjct: 689 NKVGWTPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALR 734
>gi|116534990 ankyrin-like protein 1 [Homo sapiens]
Length = 1119
Score = 71.2 bits (173), Expect = 8e-13
Identities = 44/156 (28%), Positives = 86/156 (55%), Gaps = 2/156 (1%)
Query: 89 LDSLSIHQLAAQGELDQLKEHLRKGD-NLVNKPDERGFTPLIWASAFGEIETVRFLLEWG 147
+D+ +H AA+G+++ +++ R ++++ D+ G TPL A +IE+V+FLL G
Sbjct: 62 MDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRG 121
Query: 148 ADPHILAKERESALSLASTGGYTDIVGLLLE-RDVDINIYDWNGGTPLLYAVRGNHVKCV 206
A+P++ + L +A G +++ +LLE R +D+N+ NG T ++ A N+ + +
Sbjct: 122 ANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEAL 181
Query: 207 EALLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
+ LL +GA G P+ A G ++ ++I
Sbjct: 182 QILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEII 217
Score = 54.7 bits (130), Expect = 8e-08
Identities = 48/150 (32%), Positives = 73/150 (48%), Gaps = 11/150 (7%)
Query: 102 ELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESAL 161
++ Q+KE LV D G TPL +A G +V LL + H +K+++S L
Sbjct: 398 QMQQIKE-------LVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPL 450
Query: 162 SLASTGGYTDIVGLLLERDVD---INIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTT 218
A++ G + LL+ D +N D +G TPL A + H K V+ LL +GA L
Sbjct: 451 HFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGA-LFL 509
Query: 219 EADSGYTPMDLAVALGYRKVQQVIENHILK 248
+G+T + A GY + +VI + LK
Sbjct: 510 SDHNGWTALHHASMGGYTQTMKVILDTNLK 539
Score = 53.5 bits (127), Expect = 2e-07
Identities = 46/148 (31%), Positives = 73/148 (49%), Gaps = 9/148 (6%)
Query: 75 NRQRGNEVSALPATLDSLS-IHQLAAQGELDQLKEHLR--KGDNLVNKPDERGFTPLIWA 131
N G VS + D S +H A+ G ++ + L+ L+N+ D G TPL A
Sbjct: 430 NNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLA 489
Query: 132 SAFGEIETVRFLLEWGADPHILAKERE--SALSLASTGGYTDIVGLLLERDVDI-NIYDW 188
+ G + V+ LL+ GA + + +AL AS GGYT + ++L+ ++ + D
Sbjct: 490 AKNGHDKVVQLLLKKGA---LFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDE 546
Query: 189 NGGTPLLYAVRGNHVKCVEALLARGADL 216
+G T L +A R H K V LL+ AD+
Sbjct: 547 DGNTALHFAAREGHAKAVALLLSHNADI 574
Score = 41.2 bits (95), Expect = 0.001
Identities = 45/186 (24%), Positives = 71/186 (38%), Gaps = 44/186 (23%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNL-------VNKPDERGFTPLIWASAFGEIETVRFLLEW 146
IHQ A G + ++ LR G+ +N + TPL A G++E ++ L+
Sbjct: 202 IHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDN 261
Query: 147 GADPHILAKERESALSLASTGGYTDIVGLLLER--------------------------- 179
GA + K R +A+ A+T G T+IV L++
Sbjct: 262 GAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDH 321
Query: 180 ----------DVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDL 229
DIN D G +PL+ A V LL++GA + + + G + L
Sbjct: 322 HELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHL 381
Query: 230 AVALGY 235
V Y
Sbjct: 382 TVQQPY 387
Score = 38.9 bits (89), Expect = 0.005
Identities = 31/98 (31%), Positives = 46/98 (46%), Gaps = 3/98 (3%)
Query: 93 SIHQLAAQGELDQLKEHLRKGD---NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGAD 149
+IH A QG + +K + ++VN D T L AS F E +L+ GAD
Sbjct: 275 AIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGAD 334
Query: 150 PHILAKERESALSLASTGGYTDIVGLLLERDVDINIYD 187
+ + E S L LA+ +IV LLL + ++I D
Sbjct: 335 INKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKD 372
Score = 32.7 bits (73), Expect = 0.33
Identities = 19/56 (33%), Positives = 30/56 (53%)
Query: 190 GGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
G TPL AV N ++ V+ LL+RGA+ + P+ +AV +V +V+ H
Sbjct: 98 GNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEH 153
>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
Length = 226
Score = 71.2 bits (173), Expect = 8e-13
Identities = 48/154 (31%), Positives = 74/154 (48%)
Query: 89 LDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGA 148
+ +L + LA G+L++LKE + +L + D+ T L WA + G E V FLL+ G
Sbjct: 5 VSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGV 64
Query: 149 DPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEA 208
+ S L +A++ G +IV LL + +N + NG TPL YA N +
Sbjct: 65 PVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVM 124
Query: 209 LLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
LL GA+ + T M A A G K+ ++
Sbjct: 125 LLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
Score = 58.5 bits (140), Expect = 6e-09
Identities = 42/137 (30%), Positives = 66/137 (48%), Gaps = 1/137 (0%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+H A+ G + +K L KG VN ++ G TPL +A++ E LLE GA+P
Sbjct: 77 LHIAASAGRDEIVKALLGKGAQ-VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
+A+ A+ G ++ +LL NI D G TPL A V+ + L+++G
Sbjct: 136 DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195
Query: 214 ADLTTEADSGYTPMDLA 230
A + E TP+ +A
Sbjct: 196 ASIYIENKEEKTPLQVA 212
>gi|16975496 cortactin binding protein 2 [Homo sapiens]
Length = 1663
Score = 70.9 bits (172), Expect = 1e-12
Identities = 63/179 (35%), Positives = 84/179 (46%), Gaps = 14/179 (7%)
Query: 65 SSLKHSTTLTNRQRGNEVSAL---PATLDSLSIHQLAAQGELDQLKEHLRKGDN--LVNK 119
SSL TT+ N VSA P DSL + A G L L G L +
Sbjct: 654 SSLVIPTTIAFCSSINPVSASSCRPGASDSLLV---TASGWSPSLTPLLMSGGPAPLAGR 710
Query: 120 PDERGFTPLIWASAFGEIETVRFLL-EWGADPHILAKERESALSLASTGGYTDIVGLLLE 178
P T L A+A G + + LL E G D + ++ SAL A+ G+TD V LLL
Sbjct: 711 P-----TLLQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLS 765
Query: 179 RDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK 237
+ +N D NG TPL A H +CVE L++ A++ AD G TP+ LA G ++
Sbjct: 766 AEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKE 824
Score = 62.8 bits (151), Expect = 3e-10
Identities = 43/141 (30%), Positives = 67/141 (47%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHIL 153
+ Q AAQG + L L + +N E G + L A+ G + VR LL A +
Sbjct: 714 LQQAAAQGNVTLLSMLLNEEGLDINYSCEDGHSALYSAAKNGHTDCVRLLLSAEAQVNAA 773
Query: 154 AKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARG 213
K + L A+ G+ + V LL+ D +IN G TPL A + + +C++ LL G
Sbjct: 774 DKNGFTPLCAAAAQGHFECVELLISYDANINHAADGGQTPLYLACKNGNKECIKLLLEAG 833
Query: 214 ADLTTEADSGYTPMDLAVALG 234
+ + + G+TP+ AV G
Sbjct: 834 TNRSVKTTDGWTPVHAAVDTG 854
Score = 51.2 bits (121), Expect = 9e-07
Identities = 35/118 (29%), Positives = 60/118 (50%), Gaps = 1/118 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
+++ A G D ++ L + VN D+ GFTPL A+A G E V L+ + A+ +
Sbjct: 747 ALYSAAKNGHTDCVRL-LLSAEAQVNAADKNGFTPLCAAAAQGHFECVELLISYDANINH 805
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALL 210
A ++ L LA G + + LLLE + ++ +G TP+ AV +V ++ L+
Sbjct: 806 AADGGQTPLYLACKNGNKECIKLLLEAGTNRSVKTTDGWTPVHAAVDTGNVDSLKLLM 863
>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
Length = 919
Score = 70.5 bits (171), Expect = 1e-12
Identities = 46/157 (29%), Positives = 81/157 (51%), Gaps = 3/157 (1%)
Query: 90 DSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGAD 149
D ++H A G LD + + G + K D++G+TPL A++ G+I V+ LL G +
Sbjct: 148 DRRALHWAAYMGHLDVVALLINHGAEVTCK-DKKGYTPLHAAASNGQINVVKHLLNLGVE 206
Query: 150 PHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNH-VKCVEA 208
+ +AL +A G +V L++ ++N + NG TPL +A H C+E
Sbjct: 207 IDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLEL 266
Query: 209 LLARGADLTTEADSGYTPMDLAVALG-YRKVQQVIEN 244
L+ GAD+ ++ G +P+ + G + + Q +I+N
Sbjct: 267 LVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQN 303
Score = 58.9 bits (141), Expect = 4e-09
Identities = 39/140 (27%), Positives = 68/140 (48%), Gaps = 1/140 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H A G ++ + L KG N +N D++ L WA+ G ++ V L+ GA+
Sbjct: 118 ALHHAALNGHVEMVNLLLAKGAN-INAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTC 176
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K+ + L A++ G ++V LL V+I+ + G T L A V L+
Sbjct: 177 KDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELIDY 236
Query: 213 GADLTTEADSGYTPMDLAVA 232
GA++ ++G+TP+ A A
Sbjct: 237 GANVNQPNNNGFTPLHFAAA 256
Score = 58.2 bits (139), Expect = 7e-09
Identities = 50/166 (30%), Positives = 74/166 (44%), Gaps = 6/166 (3%)
Query: 94 IHQLAAQGELDQLKEHLRKGDN--LVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH 151
+H G L+ L DN V+ D +G TPL+ A A+G I+ V LLE A+
Sbjct: 613 LHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVD 672
Query: 152 ILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLA 211
+ +AL G+ + V +LLE++V I D G TPL YA H + LL
Sbjct: 673 TVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYAAARGHATWLSELLQ 732
Query: 212 RG---ADLTTEADSGYTPMDLAVALGYRK-VQQVIENHILKLFQSN 253
D + + GYTP+ A G ++ ++E + F N
Sbjct: 733 MALSEEDCCFKDNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGN 778
Score = 55.1 bits (131), Expect = 6e-08
Identities = 37/133 (27%), Positives = 65/133 (48%), Gaps = 4/133 (3%)
Query: 117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 176
VN D+ TPL A+A ++ ++ + ++ + +AL A+ G+ ++V LL
Sbjct: 75 VNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLL 134
Query: 177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 236
L + +IN +D L +A H+ V L+ GA++T + GYTP+ A + G
Sbjct: 135 LAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNG-- 192
Query: 237 KVQQVIENHILKL 249
Q + H+L L
Sbjct: 193 --QINVVKHLLNL 203
Score = 53.5 bits (127), Expect = 2e-07
Identities = 39/131 (29%), Positives = 59/131 (45%), Gaps = 4/131 (3%)
Query: 117 VNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVGLL 176
VN D G T L A+ G +E V LL GA+ + K+ AL A+ G+ D+V LL
Sbjct: 108 VNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALL 167
Query: 177 LERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYR 236
+ ++ D G TPL A + V+ LL G ++ G T + +A G
Sbjct: 168 INHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNG-- 225
Query: 237 KVQQVIENHIL 247
Q + N ++
Sbjct: 226 --QDAVVNELI 234
Score = 53.1 bits (126), Expect = 2e-07
Identities = 38/141 (26%), Positives = 67/141 (47%), Gaps = 3/141 (2%)
Query: 98 AAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPH---ILA 154
A +G + ++ + G ++ K + TPL + G +R LLE +P +
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642
Query: 155 KERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGA 214
+ ++ L LA G+ D V LLLE++ +++ D G T L + H +CV+ LL +
Sbjct: 643 AKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 702
Query: 215 DLTTEADSGYTPMDLAVALGY 235
+ + G TP+ A A G+
Sbjct: 703 SILCKDSRGRTPLHYAAARGH 723
Score = 52.4 bits (124), Expect = 4e-07
Identities = 43/161 (26%), Positives = 72/161 (44%), Gaps = 4/161 (2%)
Query: 88 TLDS---LSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLL 144
TLDS +H A G+ + ++ + G VN D TPL A A E V+ L+
Sbjct: 11 TLDSEKRTPLHVAAFLGDAEIIELLILSGAR-VNAKDNMWLTPLHRAVASRSEEAVQVLI 69
Query: 145 EWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVK 204
+ AD + K ++ L +A+ +++ +N+ D G T L +A HV+
Sbjct: 70 KHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVE 129
Query: 205 CVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENH 245
V LLA+GA++ + A +G+ V ++ NH
Sbjct: 130 MVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINH 170
Score = 52.0 bits (123), Expect = 5e-07
Identities = 54/208 (25%), Positives = 79/208 (37%), Gaps = 11/208 (5%)
Query: 45 CTPEPVNPEPDASVSSPQAGSSLKHSTTLTNR--------QRGNEVSALPATLDSLSIHQ 96
C VN D ++ S S L H T + R Q G E+ + + +H
Sbjct: 263 CLELLVNNGADVNIQSKDGKSPL-HMTAVHGRFTRSQTLIQNGGEIDCVDKD-GNTPLHV 320
Query: 97 LAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKE 156
A G + L LR K PL A+ + R LL G + K
Sbjct: 321 AARYGH-ELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKF 379
Query: 157 RESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADL 216
+ L A+ GG + + LL D + D G TPL YA H C+E L+ GA++
Sbjct: 380 GRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANV 439
Query: 217 TTEADSGYTPMDLAVALGYRKVQQVIEN 244
D G T + A A + + ++ N
Sbjct: 440 NETDDWGRTALHYAAASDMDRNKTILGN 467
Score = 50.1 bits (118), Expect = 2e-06
Identities = 62/243 (25%), Positives = 101/243 (41%), Gaps = 22/243 (9%)
Query: 21 LGDPEDPGEEAADGSDTVVLSLFPCTPEPVNPEPDASVSSPQAGSSLKHSTTLTNRQ--- 77
LG+ D EE + C + + + S+ + +S+ ++ +RQ
Sbjct: 465 LGNAHDNSEELERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLE 524
Query: 78 -------RGNEVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIW 130
G E S AT L LAA Q E L + ++ DE+G T L
Sbjct: 525 LLLERTNSGFEESDSGATKSPL---HLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDL 581
Query: 131 ASAFGEIETVRFLLEWGADPHILAKE---RESALSLASTGGYTDIVGLLLE---RDVDIN 184
A+ G E V L+ GA I K+ + + L + G+T + LLLE ++
Sbjct: 582 AAFKGHTECVEALINPGAS--IFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVD 639
Query: 185 IYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRK-VQQVIE 243
+ D G TPL+ AV H+ V LL + A++ T G T + + G+ + VQ ++E
Sbjct: 640 VKDAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLE 699
Query: 244 NHI 246
+
Sbjct: 700 QEV 702
Score = 45.8 bits (107), Expect = 4e-05
Identities = 44/157 (28%), Positives = 68/157 (43%), Gaps = 9/157 (5%)
Query: 94 IHQLAAQGELDQLKEHLRKG---DNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADP 150
+H AA+G L E L+ ++ K D +G+TPL WA G + LLE
Sbjct: 715 LHYAAARGHATWLSELLQMALSEEDCCFK-DNQGYTPLHWACYNGNENCIEVLLEQKCFR 773
Query: 151 HILAKERESALSLASTGGYTDIVGLLLERDVDINIY---DWNGGTPLLYAVRGNHVKCVE 207
+ + L A + + LLL +D +I D G TPL A +HV+C++
Sbjct: 774 KFIGNPF-TPLHCAIINDHGNCASLLLGA-IDSSIVSCRDDKGRTPLRAAAFADHVECLQ 831
Query: 208 ALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIEN 244
LL A + +SG T + +A G ++ N
Sbjct: 832 LLLRHSAPVNAVDNSGKTALMMAAENGQAGAVDILVN 868
Score = 44.7 bits (104), Expect = 8e-05
Identities = 50/187 (26%), Positives = 77/187 (41%), Gaps = 31/187 (16%)
Query: 94 IHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFG----------------EI 137
+H AA ++ + G N VN+ D+ G T L +A+A E+
Sbjct: 417 LHYAAANCHFHCIETLVTTGAN-VNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEEL 475
Query: 138 ETVR------------FLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINI 185
E R FLL+ A+P I KE +++ A+ G+ + LLLER
Sbjct: 476 ERARELKEKEATLCLEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFE 535
Query: 186 YDWNGGT--PLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIE 243
+G T PL A H + +E LL DL + G T +DLA G+ + + +
Sbjct: 536 ESDSGATKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALI 595
Query: 244 NHILKLF 250
N +F
Sbjct: 596 NPGASIF 602
Score = 42.4 bits (98), Expect = 4e-04
Identities = 28/102 (27%), Positives = 50/102 (49%), Gaps = 1/102 (0%)
Query: 115 NLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHILAKERESALSLASTGGYTDIVG 174
++V+ D++G TPL A+ +E ++ LL A + + ++AL +A+ G V
Sbjct: 805 SIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGAVD 864
Query: 175 LLLER-DVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGAD 215
+L+ D+ + D + TPL A H KC +L + D
Sbjct: 865 ILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQD 906
Score = 38.1 bits (87), Expect = 0.008
Identities = 27/94 (28%), Positives = 44/94 (46%)
Query: 149 DPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEA 208
D + L E+ + L +A+ G +I+ LL+ +N D TPL AV + V+
Sbjct: 8 DVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQV 67
Query: 209 LLARGADLTTEADSGYTPMDLAVALGYRKVQQVI 242
L+ AD+ + TP+ +A A K +VI
Sbjct: 68 LIKHSADVNARDKNWQTPLHVAAANKAVKCAEVI 101
Score = 33.5 bits (75), Expect = 0.19
Identities = 20/71 (28%), Positives = 33/71 (46%)
Query: 175 LLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLARGADLTTEADSGYTPMDLAVALG 234
+L+ + D+N D TPL A + +E L+ GA + + + TP+ AVA
Sbjct: 1 MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60
Query: 235 YRKVQQVIENH 245
+ QV+ H
Sbjct: 61 SEEAVQVLIKH 71
>gi|39812133 ankyrin repeat domain 2 isoform a [Homo sapiens]
Length = 360
Score = 70.5 bits (171), Expect = 1e-12
Identities = 46/137 (33%), Positives = 71/137 (51%), Gaps = 1/137 (0%)
Query: 93 SIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETVRFLLEWGADPHI 152
++H+ + +G ++ L++ L G V+ D T + WA G +E V+ L GAD ++
Sbjct: 184 ALHRASLEGHMEILEKLLDNGAT-VDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNV 242
Query: 153 LAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRGNHVKCVEALLAR 212
K + L +A G +IV L ++IN D G T L AVR N K ++ LL
Sbjct: 243 RDKLLSTPLHVAVRTGQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLH 302
Query: 213 GADLTTEADSGYTPMDL 229
GAD+ T+ +G TP DL
Sbjct: 303 GADMMTKNLAGKTPTDL 319
Score = 58.2 bits (139), Expect = 7e-09
Identities = 48/179 (26%), Positives = 81/179 (45%), Gaps = 1/179 (0%)
Query: 81 EVSALPATLDSLSIHQLAAQGELDQLKEHLRKGDNLVNKPDERGFTPLIWASAFGEIETV 140
E + +D + + A +G++ +++ L G + + D+ T L AS G +E +
Sbjct: 139 EPEEITGPVDEETFLKAAVEGKMKVIEKFLADGGS-ADTCDQFRRTALHRASLEGHMEIL 197
Query: 141 RFLLEWGADPHILAKERESALSLASTGGYTDIVGLLLERDVDINIYDWNGGTPLLYAVRG 200
LL+ GA + +A+ A GG+ ++V LL D N+ D TPL AVR
Sbjct: 198 EKLLDNGATVDFQDRLDCTAMHWACRGGHLEVVKLLQSHGADTNVRDKLLSTPLHVAVRT 257
Query: 201 NHVKCVEALLARGADLTTEADSGYTPMDLAVALGYRKVQQVIENHILKLFQSNLVPADP 259
V+ VE L+ G ++ G T + AV L K+ +++ H + NL P
Sbjct: 258 GQVEIVEHFLSLGLEINARDREGDTALHDAVRLNRYKIIKLLLLHGADMMTKNLAGKTP 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.132 0.382
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,790,250
Number of Sequences: 37866
Number of extensions: 514167
Number of successful extensions: 3796
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 338
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 1604
Number of HSP's gapped (non-prelim): 1440
length of query: 260
length of database: 18,247,518
effective HSP length: 100
effective length of query: 160
effective length of database: 14,460,918
effective search space: 2313746880
effective search space used: 2313746880
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.