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Search of human proteins with 4506475
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506475 renin preproprotein [Homo sapiens]
(406 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506475 renin preproprotein [Homo sapiens] 830 0.0
gi|4503143 cathepsin D preproprotein [Homo sapiens] 328 4e-90
gi|4758754 napsin A preproprotein [Homo sapiens] 298 6e-81
gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens] 287 1e-77
gi|23943854 pepsinogen 5, group I [Homo sapiens] 261 1e-69
gi|119372302 pepsinogen 4, group I [Homo sapiens] 259 4e-69
gi|119372298 pepsinogen 3, group I [Homo sapiens] 259 4e-69
gi|4505757 progastricsin (pepsinogen C) [Homo sapiens] 234 8e-62
gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens] 176 4e-44
gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprot... 104 2e-22
gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprot... 100 2e-21
gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprot... 92 6e-19
gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprote... 83 5e-16
gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprot... 74 2e-13
gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprot... 58 1e-08
gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo s... 58 2e-08
gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprot... 47 2e-05
>gi|4506475 renin preproprotein [Homo sapiens]
Length = 406
Score = 830 bits (2143), Expect = 0.0
Identities = 406/406 (100%), Positives = 406/406 (100%)
Query: 1 MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW 60
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW
Sbjct: 1 MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEW 60
Query: 61 SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL 120
SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL
Sbjct: 61 SQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRL 120
Query: 121 YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM 180
YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM
Sbjct: 121 YTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEM 180
Query: 181 PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG 240
PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG
Sbjct: 181 PALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGG 240
Query: 241 QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG 300
QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG
Sbjct: 241 QIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISG 300
Query: 301 STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK 360
STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK
Sbjct: 301 STSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKK 360
Query: 361 LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR 406
LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Sbjct: 361 LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR 406
>gi|4503143 cathepsin D preproprotein [Homo sapiens]
Length = 412
Score = 328 bits (842), Expect = 4e-90
Identities = 169/400 (42%), Positives = 246/400 (61%), Gaps = 22/400 (5%)
Query: 24 LPTDTTTFKRIFLKRMPSIRESLKERG---VDMARLGP--EWSQPMKRLTLGNTTSSVIL 78
L + RI L + SIR ++ E G D+ GP ++SQ + +T G +L
Sbjct: 14 LAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPE--VL 71
Query: 79 TNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSY 138
NYMD QYYGEIGIGTPPQ F VVFDTGSSN+WVPS C L AC H +++ SS+Y
Sbjct: 72 KNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTY 131
Query: 139 KHNGTELTLRYSTGTVSGFLSQDIITV-----------GGITV-TQMFGEVTEMPALPFM 186
NGT + Y +G++SG+LSQD ++V GG+ V Q+FGE T+ P + F+
Sbjct: 132 VKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFI 191
Query: 187 LAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGG 246
A+FDG++GM + ++ V P+FDN++ Q ++ +++FSFY +RD + GG+++LGG
Sbjct: 192 AAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQP--GGELMLGG 249
Query: 247 SDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIE 306
+D ++Y+G+ Y+N+ + WQ+ + V V S LC++GC A+VDTG S + G +
Sbjct: 250 TDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVR 309
Query: 307 KLMEALGAKKRL-FDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLA 365
+L +A+GA + +Y++ C + TLP I+ LGGK Y L+ DY + S + K LC
Sbjct: 310 ELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSG 369
Query: 366 IHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALA 405
MDIPPP+GP W LG FI ++YT FDR NNR+GFA A
Sbjct: 370 FMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEA 409
>gi|4758754 napsin A preproprotein [Homo sapiens]
Length = 420
Score = 298 bits (763), Expect = 6e-81
Identities = 157/358 (43%), Positives = 211/358 (58%), Gaps = 13/358 (3%)
Query: 60 WSQPMKRLTLGNTTSS-----VILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPS 114
W +P + LG + V L+NY D QY+GEIG+GTPPQ F V FDTGSSN+WVPS
Sbjct: 47 WREPAELPKLGAPSPGDKPIFVPLSNYRDVQYFGEIGLGTPPQNFTVAFDTGSSNLWVPS 106
Query: 115 SKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGIT-VTQM 173
+C C H FD SSS++ NGT+ ++Y TG V G LS+D +T+GGI + +
Sbjct: 107 RRCHFFSVPCWLHHRFDPKASSSFQANGTKFAIQYGTGRVDGILSEDKLTIGGIKGASVI 166
Query: 174 FGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSE 233
FGE P+L F A FDG++G+GF ++ V P D ++ QG+L + VFSFY NRD E
Sbjct: 167 FGEALWEPSLVFAFAHFDGILGLGFPILSVEGVRPPMDVLVEQGLLDKPVFSFYLNRDPE 226
Query: 234 NSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDT 293
GG++VLGGSDP HY ++ + WQI M+ V VG LC GC A++DT
Sbjct: 227 EPD--GGELVLGGSDPAHYIPPLTFVPVTVPAYWQIHMERVKVGPGLTLCAKGCAAILDT 284
Query: 294 GASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEGPTLPDISFHLGGKEYTLTSADYVF 352
G S I+G T I L A+G L +Y++ C+E P LP +SF LGG + LT+ DYV
Sbjct: 285 GTSLITGPTEEIRALHAAIGGIPLLAGEYIILCSEIPKLPAVSFLLGGVWFNLTAHDYVI 344
Query: 353 QESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDR----RNNRIGFALAR 406
Q + + +LC A+D+PPP GP W LG F+ + FDR + R+G A AR
Sbjct: 345 QTTRNGVRLCLSGFQALDVPPPAGPFWILGDVFLGTYVAVFDRGDMKSSARVGLARAR 402
>gi|4503145 cathepsin E isoform a preproprotein [Homo sapiens]
Length = 396
Score = 287 bits (735), Expect = 1e-77
Identities = 143/377 (37%), Positives = 222/377 (58%), Gaps = 9/377 (2%)
Query: 33 RIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLG---NTTSSVILTNYMDTQYYGE 89
R+ L+R PS+++ L+ R ++ + M + T + ++ L NY+D +Y+G
Sbjct: 23 RVPLRRHPSLKKKLRARS-QLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGT 81
Query: 90 IGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY 149
I IG+PPQ F V+FDTGSSN+WVPS C+ AC H F S SS+Y G +++Y
Sbjct: 82 ISIGSPPQNFTVIFDTGSSNLWVPSVYCTS--PACKTHSRFQPSQSSTYSQPGQSFSIQY 139
Query: 150 STGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTP 208
TG++SG + D ++V G+TV Q FGE P F+ AEFDG++G+G+ A+G VTP
Sbjct: 140 GTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTP 199
Query: 209 IFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQ 268
+FDN+++Q ++ +FS Y + + E G +++ GG D H+ G+ +++ + K WQ
Sbjct: 200 VFDNMMAQNLVDLPMFSVYMSSNPEGGA--GSELIFGGYDHSHFSGSLNWVPVTKQAYWQ 257
Query: 269 IQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEG 328
I + + VG + + C +GC A+VDTG S I+G + I++L A+GA +Y V+C
Sbjct: 258 IALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANL 317
Query: 329 PTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRK 388
+PD++F + G YTL+ Y + + C+ +DI PP GP W LG FIR+
Sbjct: 318 NVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQ 377
Query: 389 FYTEFDRRNNRIGFALA 405
FY+ FDR NNR+G A A
Sbjct: 378 FYSVFDRGNNRVGLAPA 394
>gi|23943854 pepsinogen 5, group I [Homo sapiens]
Length = 388
Score = 261 bits (666), Expect = 1e-69
Identities = 140/384 (36%), Positives = 213/384 (55%), Gaps = 30/384 (7%)
Query: 33 RIFLKRMPSIRESLKERGV-----------DMARLGPEWSQPMKRLTLGNTTSSVILTNY 81
++ L R S+R +L ERG+ + P+W P L NY
Sbjct: 19 KVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP-------TLVDEQPLENY 71
Query: 82 MDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHN 141
+D +Y+G IGIGTP Q F VVFDTGSSN+WVPS CS L AC H F+ DSS+Y+
Sbjct: 72 LDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNRFNPEDSSTYQST 129
Query: 142 GTELTLRYSTGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIE 200
+++ Y TG+++G L D + VGGI+ T Q+FG P A FDG++G+ +
Sbjct: 130 SETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPS 189
Query: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYIN 260
+ TP+FDNI +QG++ +D+FS Y + D ++ G ++ GG D +Y G+ +++
Sbjct: 190 ISSSGATPVFDNIWNQGLVSQDLFSVYLSADDKS----GSVVIFGGIDSSYYTGSLNWVP 245
Query: 261 LIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRL-F 319
+ G WQI + +++ T+ C +GC A+VDTG S ++G TS I + +GA +
Sbjct: 246 VTVEGYWQITVDSITMNGETIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDG 305
Query: 320 DYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTW 379
D VV C+ +LPDI F + G +Y + + Y+ Q S+ C M++P +G W
Sbjct: 306 DMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----SEGSCISGFQGMNVPTESGELW 361
Query: 380 ALGATFIRKFYTEFDRRNNRIGFA 403
LG FIR+++T FDR NN++G A
Sbjct: 362 ILGDVFIRQYFTVFDRANNQVGLA 385
>gi|119372302 pepsinogen 4, group I [Homo sapiens]
Length = 388
Score = 259 bits (661), Expect = 4e-69
Identities = 139/384 (36%), Positives = 212/384 (55%), Gaps = 30/384 (7%)
Query: 33 RIFLKRMPSIRESLKERGV-----------DMARLGPEWSQPMKRLTLGNTTSSVILTNY 81
++ L R S+R +L ERG+ + P+W P L NY
Sbjct: 19 KVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWEAP-------TLVDEQPLENY 71
Query: 82 MDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHN 141
+D +Y+G IGIGTP Q F VVFDTGSSN+WVPS CS L AC H F+ DSS+Y+
Sbjct: 72 LDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNRFNPEDSSTYQST 129
Query: 142 GTELTLRYSTGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIE 200
+++ Y TG+++G L D + VGGI+ T Q+FG P A FDG++G+ +
Sbjct: 130 SETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPS 189
Query: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYIN 260
+ TP+FDNI +QG++ +D+FS Y + D ++ G ++ GG D +Y G+ +++
Sbjct: 190 ISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS----GSVVIFGGIDSSYYTGSLNWVP 245
Query: 261 LIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRL-F 319
+ G WQI + +++ + C +GC A+VDTG S ++G TS I + +GA +
Sbjct: 246 VTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDG 305
Query: 320 DYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTW 379
D VV C+ +LPDI F + G +Y + + Y+ Q S+ C M++P +G W
Sbjct: 306 DMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----SEGSCISGFQGMNLPTESGELW 361
Query: 380 ALGATFIRKFYTEFDRRNNRIGFA 403
LG FIR+++T FDR NN++G A
Sbjct: 362 ILGDVFIRQYFTVFDRANNQVGLA 385
>gi|119372298 pepsinogen 3, group I [Homo sapiens]
Length = 388
Score = 259 bits (661), Expect = 4e-69
Identities = 139/384 (36%), Positives = 212/384 (55%), Gaps = 30/384 (7%)
Query: 33 RIFLKRMPSIRESLKERGV-----------DMARLGPEWSQPMKRLTLGNTTSSVILTNY 81
++ L R S+R +L ERG+ + P+W P L NY
Sbjct: 19 KVPLIRKKSLRRTLSERGLLKDFLKKHNLNPARKYFPQWKAP-------TLVDEQPLENY 71
Query: 82 MDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHN 141
+D +Y+G IGIGTP Q F VVFDTGSSN+WVPS CS L AC H F+ DSS+Y+
Sbjct: 72 LDMEYFGTIGIGTPAQDFTVVFDTGSSNLWVPSVYCSSL--ACTNHNRFNPEDSSTYQST 129
Query: 142 GTELTLRYSTGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIE 200
+++ Y TG+++G L D + VGGI+ T Q+FG P A FDG++G+ +
Sbjct: 130 SETVSITYGTGSMTGILGYDTVQVGGISDTNQIFGLSETEPGSFLYYAPFDGILGLAYPS 189
Query: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYIN 260
+ TP+FDNI +QG++ +D+FS Y + D ++ G ++ GG D +Y G+ +++
Sbjct: 190 ISSSGATPVFDNIWNQGLVSQDLFSVYLSADDQS----GSVVIFGGIDSSYYTGSLNWVP 245
Query: 261 LIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRL-F 319
+ G WQI + +++ + C +GC A+VDTG S ++G TS I + +GA +
Sbjct: 246 VTVEGYWQITVDSITMNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDG 305
Query: 320 DYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTW 379
D VV C+ +LPDI F + G +Y + + Y+ Q S+ C M++P +G W
Sbjct: 306 DMVVSCSAISSLPDIVFTINGVQYPVPPSAYILQ----SEGSCISGFQGMNLPTESGELW 361
Query: 380 ALGATFIRKFYTEFDRRNNRIGFA 403
LG FIR+++T FDR NN++G A
Sbjct: 362 ILGDVFIRQYFTVFDRANNQVGLA 385
>gi|4505757 progastricsin (pepsinogen C) [Homo sapiens]
Length = 388
Score = 234 bits (598), Expect = 8e-62
Identities = 132/377 (35%), Positives = 204/377 (54%), Gaps = 13/377 (3%)
Query: 33 RIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGI 92
++ LK+ SIRE++KE+G+ L P + G+ + + YMD Y+GEI I
Sbjct: 20 KVPLKKFKSIRETMKEKGLLGEFLRTHKYDPAWKYRFGDLSVTYEPMAYMDAAYFGEISI 79
Query: 93 GTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTG 152
GTPPQ F V+FDTGSSN+WVPS C AC H F+ S+SS+Y NG +L+Y +G
Sbjct: 80 GTPPQNFLVLFDTGSSNLWVPSVYCQS--QACTSHSRFNPSESSTYSTNGQTFSLQYGSG 137
Query: 153 TVSGFLSQDIITVGGITV-TQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFD 211
+++GF D +TV I V Q FG P F+ A+FDG++G+ + ++ T
Sbjct: 138 SLTGFFGYDTLTVQSIQVPNQEFGLSENEPGTNFVYAQFDGIMGLAYPALSVDEATTAMQ 197
Query: 212 NIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQM 271
++ +G L VFS Y S S GG +V GG D Y G ++ + + WQI +
Sbjct: 198 GMVQEGALTSPVFSVYL---SNQQGSSGGAVVFGGVDSSLYTGQIYWAPVTQELYWQIGI 254
Query: 272 KGVSV-GSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLF-DYVVKCNEGP 329
+ + G ++ C +GC A+VDTG S ++ + L++A GA++ + ++V CN
Sbjct: 255 EEFLIGGQASGWCSEGCQAIVDTGTSLLTVPQQYMSALLQATGAQEDEYGQFLVNCNSIQ 314
Query: 330 TLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTG-PTWALGATFIRK 388
LP ++F + G E+ L + Y+ S+ CT+ + + G P W LG F+R
Sbjct: 315 NLPSLTFIINGVEFPLPPSSYIL----SNNGYCTVGVEPTYLSSQNGQPLWILGDVFLRS 370
Query: 389 FYTEFDRRNNRIGFALA 405
+Y+ +D NNR+GFA A
Sbjct: 371 YYSVYDLGNNRVGFATA 387
>gi|23110952 cathepsin E isoform b preproprotein [Homo sapiens]
Length = 363
Score = 176 bits (445), Expect = 4e-44
Identities = 92/253 (36%), Positives = 148/253 (58%), Gaps = 9/253 (3%)
Query: 33 RIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLG---NTTSSVILTNYMDTQYYGE 89
R+ L+R PS+++ L+ R ++ + M + T + ++ L NY+D +Y+G
Sbjct: 23 RVPLRRHPSLKKKLRARS-QLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGT 81
Query: 90 IGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRY 149
I IG+PPQ F V+FDTGSSN+WVPS C+ AC H F S SS+Y G +++Y
Sbjct: 82 ISIGSPPQNFTVIFDTGSSNLWVPSVYCTS--PACKTHSRFQPSQSSTYSQPGQSFSIQY 139
Query: 150 STGTVSGFLSQDIITVGGITVT-QMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTP 208
TG++SG + D ++V G+TV Q FGE P F+ AEFDG++G+G+ A+G VTP
Sbjct: 140 GTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTP 199
Query: 209 IFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQ 268
+FDN+++Q ++ +FS Y + + E G +++ GG D H+ G+ +++ + K WQ
Sbjct: 200 VFDNMMAQNLVDLPMFSVYMSSNPEG--GAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQ 257
Query: 269 IQMKGVSVGSSTL 281
I + + TL
Sbjct: 258 IALDNMLWSVPTL 270
>gi|19923395 beta-site APP-cleaving enzyme 2 isoform A preproprotein
[Homo sapiens]
Length = 518
Score = 104 bits (259), Expect = 2e-22
Identities = 87/346 (25%), Positives = 165/346 (47%), Gaps = 36/346 (10%)
Query: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
YY E+ IGTPPQ +++ DTGSSN V + S + T FD SS+Y+ G ++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDT------YFDTERSSTYRSKGFDV 145
Query: 146 TLRYSTGTVSGFLSQDIITV-GGITVTQMFGEVTEMPALPFML--AEFDGVVGMGF--IE 200
T++Y+ G+ +GF+ +D++T+ G + + T + F L +++G++G+ + +
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYY---NRDSENSQSLGGQIVLGGSDPQHYEGNFH 257
+ + FD++++Q + +VFS S + GG +VLGG +P Y+G+
Sbjct: 206 KPSSSLETFFDSLVTQANI-PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIW 264
Query: 258 YINLIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYISGSTSSIEKLMEALG 313
Y + + +QI++ + +G +L + + A+VD+G + + + ++EA+
Sbjct: 265 YTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVA 324
Query: 314 AKKRLFDY--------VVKC---NEGP--TLPDISFHLGGKEYTLTSADYVFQESYSSKK 360
+ ++ + C +E P P IS +L + + + + + Y
Sbjct: 325 RASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPM 384
Query: 361 L---CTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFA 403
+ + I P T +GAT + FY FDR R+GFA
Sbjct: 385 MGAGLNYECYRFGISPSTN-ALVIGATVMEGFYVIFDRAQKRVGFA 429
>gi|21040360 beta-site APP-cleaving enzyme 2 isoform C preproprotein
[Homo sapiens]
Length = 468
Score = 100 bits (250), Expect = 2e-21
Identities = 88/330 (26%), Positives = 155/330 (46%), Gaps = 54/330 (16%)
Query: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
YY E+ IGTPPQ +++ DTGSSN V + S + T FD SS+Y+ G ++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDT------YFDTERSSTYRSKGFDV 145
Query: 146 TLRYSTGTVSGFLSQDIITVG-GITVTQMFGEVTEMPALPFMLA--EFDGVVGMGF--IE 200
T++Y+ G+ +GF+ +D++T+ G + + T + F L +++G++G+ + +
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYY---NRDSENSQSLGGQIVLGGSDPQHYEGNFH 257
+ + FD++++Q + +VFS S + GG +VLGG +P Y+G+
Sbjct: 206 KPSSSLETFFDSLVTQANIP-NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIW 264
Query: 258 YINLIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYISGSTSSIEKLMEALG 313
Y + + +QI++ + +G +L + + A+VD+G + L
Sbjct: 265 YTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTL--------------LR 310
Query: 314 AKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPP 373
+++FD VV+ +L I +G L Y F S S+ L
Sbjct: 311 LPQKVFDAVVEAVARASLLYIQPMMGAG---LNYECYRFGISPSTNAL------------ 355
Query: 374 PTGPTWALGATFIRKFYTEFDRRNNRIGFA 403
+GAT + FY FDR R+GFA
Sbjct: 356 ------VIGATVMEGFYVIFDRAQKRVGFA 379
>gi|21040362 beta-site APP-cleaving enzyme 2 isoform B preproprotein
[Homo sapiens]
Length = 396
Score = 92.4 bits (228), Expect = 6e-19
Identities = 64/239 (26%), Positives = 126/239 (52%), Gaps = 19/239 (7%)
Query: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
YY E+ IGTPPQ +++ DTGSSN V + S + T FD SS+Y+ G ++
Sbjct: 92 YYLEMLIGTPPQKLQILVDTGSSNFAVAGTPHSYIDT------YFDTERSSTYRSKGFDV 145
Query: 146 TLRYSTGTVSGFLSQDIITV-GGITVTQMFGEVTEMPALPFML--AEFDGVVGMGF--IE 200
T++Y+ G+ +GF+ +D++T+ G + + T + F L +++G++G+ + +
Sbjct: 146 TVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLA 205
Query: 201 QAIGRVTPIFDNIISQGVLKEDVFSFYY---NRDSENSQSLGGQIVLGGSDPQHYEGNFH 257
+ + FD++++Q + +VFS S + GG +VLGG +P Y+G+
Sbjct: 206 KPSSSLETFFDSLVTQANI-PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIW 264
Query: 258 YINLIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYISGSTSSIEKLMEAL 312
Y + + +QI++ + +G +L + + A+VD+G + + + ++EA+
Sbjct: 265 YTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAV 323
>gi|6912266 beta-site APP-cleaving enzyme 1 isoform A preproprotein
[Homo sapiens]
Length = 501
Score = 82.8 bits (203), Expect = 5e-16
Identities = 83/356 (23%), Positives = 156/356 (43%), Gaps = 48/356 (13%)
Query: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
YY E+ +G+PPQT ++ DTGSSN V ++ L H+ + SS+Y+ +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128
Query: 146 TLRYSTGTVSGFLSQDIITV---GGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQA 202
+ Y+ G G L D++++ +TV +TE + ++G++G+ + E A
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 203 --IGRVTPIFDNIISQGVLKEDVFSF------YYNRDSENSQSLGGQIVLGGSDPQHYEG 254
+ P FD+++ Q + ++FS + SE S+GG +++GG D Y G
Sbjct: 189 RPDDSLEPFFDSLVKQTHV-PNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTG 247
Query: 255 NFHYINLIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYIS----------- 299
+ Y + + +++ + V + L + + ++VD+G + +
Sbjct: 248 SLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVK 307
Query: 300 --GSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGK------EYTLTSADYV 351
+ SS EK + ++L + P IS +L G+ T+ Y+
Sbjct: 308 SIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYL 367
Query: 352 --FQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALA 405
++ +S+ C + I + T +GA + FY FDR RIGFA++
Sbjct: 368 RPVEDVATSQDDC----YKFAISQSSTGT-VMGAVIMEGFYVVFDRARKRIGFAVS 418
>gi|21040366 beta-site APP-cleaving enzyme 1 isoform B preproprotein
[Homo sapiens]
Length = 476
Score = 73.9 bits (180), Expect = 2e-13
Identities = 79/350 (22%), Positives = 145/350 (41%), Gaps = 61/350 (17%)
Query: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
YY E+ +G+PPQT ++ DTGSSN V ++ L H+ + SS+Y+ +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128
Query: 146 TLRYSTGTVSGFLSQDIITV---GGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQA 202
+ Y+ G G L D++++ +TV +TE + ++G++G+ + E A
Sbjct: 129 YVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIA 188
Query: 203 --IGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYIN 260
G P+ SE S+GG +++GG D Y G+ Y
Sbjct: 189 RLCGAGFPL--------------------NQSEVLASVGGSMIIGGIDHSLYTGSLWYTP 228
Query: 261 LIKTGVWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYIS-------------GSTS 303
+ + +++ + V + L + + ++VD+G + + + S
Sbjct: 229 IRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAAS 288
Query: 304 SIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGK------EYTLTSADYV--FQES 355
S EK + ++L + P IS +L G+ T+ Y+ ++
Sbjct: 289 STEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDV 348
Query: 356 YSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALA 405
+S+ C + I + T +GA + FY FDR RIGFA++
Sbjct: 349 ATSQDDC----YKFAISQSSTGT-VMGAVIMEGFYVVFDRARKRIGFAVS 393
>gi|21040364 beta-site APP-cleaving enzyme 1 isoform C preproprotein
[Homo sapiens]
Length = 457
Score = 58.2 bits (139), Expect = 1e-08
Identities = 75/345 (21%), Positives = 135/345 (39%), Gaps = 70/345 (20%)
Query: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
YY E+ +G+PPQT ++ DTGSSN V ++ L H+ + SS+Y+ +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128
Query: 146 TLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGR 205
+ Y+ G G L D+ ++ F + + +P + F Q G
Sbjct: 129 YVPYTQGKWEGELGTDL---PDDSLEPFFDSLVKQTHVPNL-----------FSLQLCGA 174
Query: 206 VTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTG 265
P+ SE S+GG +++GG D Y G+ Y + +
Sbjct: 175 GFPL--------------------NQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREW 214
Query: 266 VWQIQMKGVSVGSSTLLCE----DGCLALVDTGASYIS-------------GSTSSIEKL 308
+++ + V + L + + ++VD+G + + + SS EK
Sbjct: 215 YYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKF 274
Query: 309 MEALGAKKRLFDYVVKCNEGPTLPDISFHLGGK------EYTLTSADYV--FQESYSSKK 360
+ ++L + P IS +L G+ T+ Y+ ++ +S+
Sbjct: 275 PDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQD 334
Query: 361 LCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALA 405
C + I + T +GA + FY FDR RIGFA++
Sbjct: 335 DC----YKFAISQSSTGT-VMGAVIMEGFYVVFDRARKRIGFAVS 374
>gi|169218035 PREDICTED: similar to pepsinogen 3, group I [Homo
sapiens]
Length = 87
Score = 57.8 bits (138), Expect = 2e-08
Identities = 28/79 (35%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 276 VGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRL-FDYVVKCNEGPTLPDI 334
+ + C +GC A+VDTG S ++G TS I + +GA + D VV C+ +LPDI
Sbjct: 1 MNGEAIACAEGCQAIVDTGTSLLTGPTSPIANIQSDIGASENSDGDMVVSCSAISSLPDI 60
Query: 335 SFHLGGKEYTLTSADYVFQ 353
F + G +Y + + Y+ Q
Sbjct: 61 VFTINGVQYPVPPSAYILQ 79
>gi|21040368 beta-site APP-cleaving enzyme 1 isoform D preproprotein
[Homo sapiens]
Length = 432
Score = 47.4 bits (111), Expect = 2e-05
Identities = 76/327 (23%), Positives = 125/327 (38%), Gaps = 59/327 (18%)
Query: 86 YYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTEL 145
YY E+ +G+PPQT ++ DTGSSN V ++ L H+ + SS+Y+ +
Sbjct: 75 YYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFL------HRYYQRQLSSTYRDLRKGV 128
Query: 146 TLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGR 205
+ Y+ G G L D++ G + Q EV LA G + +G I+ ++
Sbjct: 129 YVPYTQGKWEGELGTDLLCGAGFPLNQ--SEV---------LASVGGSMIIGGIDHSL-- 175
Query: 206 VTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTG 265
++ + +E + R N Q L D + + L K
Sbjct: 176 ---YTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK- 231
Query: 266 VWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTS-------SIEKLMEALGAKKRL 318
V++ +K + SST DG L + + +G+T S+ + E R+
Sbjct: 232 VFEAAVKSIKAASSTEKFPDG-FWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRI 290
Query: 319 FDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPT 378
LP +L E TS D ++ + S T+
Sbjct: 291 ----------TILP--QQYLRPVEDVATSQDDCYKFAISQSSTGTV-------------- 324
Query: 379 WALGATFIRKFYTEFDRRNNRIGFALA 405
+GA + FY FDR RIGFA++
Sbjct: 325 --MGAVIMEGFYVVFDRARKRIGFAVS 349
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,776,034
Number of Sequences: 37866
Number of extensions: 682089
Number of successful extensions: 1278
Number of sequences better than 10.0: 17
Number of HSP's better than 10.0 without gapping: 17
Number of HSP's successfully gapped in prelim test: 0
Number of HSP's that attempted gapping in prelim test: 1204
Number of HSP's gapped (non-prelim): 23
length of query: 406
length of database: 18,247,518
effective HSP length: 105
effective length of query: 301
effective length of database: 14,271,588
effective search space: 4295747988
effective search space used: 4295747988
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.