Search of human proteins with 4506217

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
sapiens]
         (226 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo ...   452   e-128
gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo ...   303   1e-82
gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]                        124   9e-29
gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]                       115   4e-26
gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]                        115   4e-26
gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]                        115   4e-26
gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]                       114   5e-26
gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]                        114   5e-26
gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]                        114   5e-26
gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]                        114   5e-26
gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]                        114   5e-26
gi|68131557 ankyrin repeat domain 28 [Homo sapiens]                   110   7e-25
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   108   3e-24
gi|62988328 ankyrin repeat domain 50 [Homo sapiens]                   106   1e-23
gi|24233530 ankyrin repeat domain 44 [Homo sapiens]                   105   2e-23
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...   105   4e-23
gi|224465233 euchromatic histone-lysine N-methyltransferase 1 is...   104   7e-23
gi|223634006 hypothetical protein LOC441869 [Homo sapiens]            103   9e-23
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   103   1e-22
gi|89363047 death-associated protein kinase 1 [Homo sapiens]          102   2e-22
gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]    102   2e-22
gi|219842212 protein phosphatase 1, regulatory (inhibitor) subun...   101   5e-22
gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit...   101   5e-22
gi|96975023 ankyrin repeat and death domain containing 1A [Homo ...   101   5e-22
gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo ...   100   8e-22
gi|157743284 ankyrin repeat domain 52 [Homo sapiens]                  100   1e-21
gi|34304381 inversin isoform a [Homo sapiens]                         100   1e-21
gi|34304379 inversin isoform b [Homo sapiens]                         100   1e-21
gi|30348954 mindbomb homolog 1 [Homo sapiens]                          99   2e-21
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu...    98   7e-21

>gi|4506217 proteasome 26S non-ATPase subunit 10 isoform 1 [Homo
           sapiens]
          Length = 226

 Score =  452 bits (1164), Expect = e-128
 Identities = 226/226 (100%), Positives = 226/226 (100%)

Query: 1   MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60
           MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
Sbjct: 1   MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60

Query: 61  QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
           QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
Sbjct: 61  QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120

Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 180
           IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC
Sbjct: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 180

Query: 181 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226
           DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG
Sbjct: 181 DEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMVEG 226


>gi|28605137 proteasome 26S non-ATPase subunit 10 isform 2 [Homo
           sapiens]
          Length = 151

 Score =  303 bits (775), Expect = 1e-82
 Identities = 149/149 (100%), Positives = 149/149 (100%)

Query: 1   MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60
           MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL
Sbjct: 1   MEGCVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL 60

Query: 61  QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120
           QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE
Sbjct: 61  QLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHE 120

Query: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAK 149
           IAVMLLEGGANPDAKDHYEATAMHRAAAK
Sbjct: 121 IAVMLLEGGANPDAKDHYEATAMHRAAAK 149



 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 40/135 (29%), Positives = 67/135 (49%)

Query: 78  HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH 137
           ++A S   +E+ +++L   +     +Q+  T LH+A S    EI   LL+ G   + KD 
Sbjct: 12  NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71

Query: 138 YEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197
              + +H AA+ G  +++  LL   A  N  +  G TPLH A  + R E A +L+  GA+
Sbjct: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131

Query: 198 IYIENKEEKTPLQVA 212
              ++  E T +  A
Sbjct: 132 PDAKDHYEATAMHRA 146


>gi|32967601 ankyrin 3 isoform 1 [Homo sapiens]
          Length = 4377

 Score =  124 bits (310), Expect = 9e-29
 Identities = 71/192 (36%), Positives = 107/192 (55%)

Query: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
           E++   +L   +  + T +   T LH A   G  E+   LLQ     +    +G +PLH+
Sbjct: 545 EDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHV 604

Query: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
           AA     ++   LL +GA  +A  +NG TPLH AA KN+ +IA  LLE GA+ +A     
Sbjct: 605 AAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQG 664

Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199
             ++H AA +G++ M+ +LL   A+ N+ +  G TPLHLA  E+RV  A++LV+QGA + 
Sbjct: 665 IASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVD 724

Query: 200 IENKEEKTPLQV 211
            + K   TPL V
Sbjct: 725 AQTKMGYTPLHV 736



 Score =  115 bits (288), Expect = 3e-26
 Identities = 67/177 (37%), Positives = 97/177 (54%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T+    TALH A  +G  E+V +L+Q G  V  K     +PLHI+A  G+ +IV+ LL +
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA  NA   +G TPLH +A +   ++A  LL+ GA+         T +H AA  G L++ 
Sbjct: 522 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVA 581

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           ++LL   AS +     G TPLH+A   +  + A LL+ QGAS +   K   TPL +A
Sbjct: 582 NLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIA 638



 Score =  114 bits (286), Expect = 5e-26
 Identities = 68/207 (32%), Positives = 112/207 (54%), Gaps = 1/207 (0%)

Query: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
           E++ E +L   +      ++  + LH A    H   V+ LLQ  VPV+D  +   + LH+
Sbjct: 314 EQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHV 373

Query: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
           AA  G  ++ K LL K A  NA   NG TPLH A  KNR ++  +LL+ GA+  A     
Sbjct: 374 AAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESG 433

Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199
            T +H AA  G++ ++  L+++ AS N  +  G T LH+A    + E  + LV  GA + 
Sbjct: 434 LTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVE 493

Query: 200 IENKEEKTPLQV-AKGGLGLILKRMVE 225
            + K+++TPL + A+ G   I++++++
Sbjct: 494 AKAKDDQTPLHISARLGKADIVQQLLQ 520



 Score =  109 bits (273), Expect = 2e-24
 Identities = 63/171 (36%), Positives = 89/171 (52%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC     +++E LL+ G  +    ++G +P+H+AA  G   IV  L+  GA  N 
Sbjct: 402 TPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNT 461

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N  G T LH AA   + E+   L++ GA  +AK   + T +H +A  G   ++  LL  
Sbjct: 462 TNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQ 521

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            AS N   T G TPLHL+  E   + A  L+  GAS+ I  K+  TPL VA
Sbjct: 522 GASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVA 572



 Score =  107 bits (267), Expect = 8e-24
 Identities = 63/193 (32%), Positives = 103/193 (53%), Gaps = 2/193 (1%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T ++  T LH A   G+  +V+ LL  G  ++ K   G +PLH  A +G +++V+ LL +
Sbjct: 264 TARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDR 323

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
            A + +  +NG +PLH A   +      +LL+     D   +   TA+H AA  G+ K+ 
Sbjct: 324 AAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVA 383

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA--K 213
            +LL  KA+ N +   G TPLH+AC + R++  +LL+  GASI    +   TP+ VA   
Sbjct: 384 KVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFM 443

Query: 214 GGLGLILKRMVEG 226
           G + ++ + M  G
Sbjct: 444 GHVNIVSQLMHHG 456



 Score =  105 bits (263), Expect = 2e-23
 Identities = 71/219 (32%), Positives = 107/219 (48%), Gaps = 30/219 (13%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           +Q+   ALH A   GH E+V  LLQ    V+     G + LHIA+ AG+ E+VK L+  G
Sbjct: 71  NQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNG 130

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP------------------------ 132
           A VNA +QNG TPL+ AA +N  E+   LL+ GA+                         
Sbjct: 131 ANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVS 190

Query: 133 -----DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEE 187
                D K      A+H AA K + K   +LL    + +++   G TPLH+A     +  
Sbjct: 191 LLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINV 250

Query: 188 AKLLVSQGASIYIENKEEKTPLQVA-KGGLGLILKRMVE 225
           A LL+++ A++    + + TPL VA K G   ++K +++
Sbjct: 251 ATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLD 289



 Score =  103 bits (258), Expect = 9e-23
 Identities = 62/183 (33%), Positives = 99/183 (54%), Gaps = 1/183 (0%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG+ E ++  ++ D +      +D +T LH +   G  +IV+ LLQ G   N    +G
Sbjct: 474 ARSGQAEVVRY-LVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSG 532

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
           ++PLH++A  G +++   LL  GA ++   + G TPLH AA   + E+A +LL+  A+PD
Sbjct: 533 YTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPD 592

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           A      T +H AA   N K+  +LL   AS +     G TPLH+A  + +++ A  L+ 
Sbjct: 593 AAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLE 652

Query: 194 QGA 196
            GA
Sbjct: 653 YGA 655



 Score =  102 bits (254), Expect = 3e-22
 Identities = 65/192 (33%), Positives = 101/192 (52%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           ++ E +L   +      +   T +H A   GH  IV  L+  G   N  +  G + LH+A
Sbjct: 414 KVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMA 473

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A +G+ E+V+ L+  GAQV A  ++  TPLH +A   + +I   LL+ GA+P+A      
Sbjct: 474 ARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGY 533

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI 200
           T +H +A +G+  +   LL + AS +I   +G TPLH+A    ++E A LL+ + AS   
Sbjct: 534 TPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDA 593

Query: 201 ENKEEKTPLQVA 212
             K   TPL VA
Sbjct: 594 AGKSGLTPLHVA 605



 Score = 99.0 bits (245), Expect = 3e-21
 Identities = 54/156 (34%), Positives = 81/156 (51%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A      +I   LL+ G   N     G + +H+AA  G  ++V  LLG+ A VN 
Sbjct: 633 TPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNL 692

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N++G TPLH AA ++R  +A +L+  GA+ DA+     T +H     GN+K+++ LL +
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH 752

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197
            A  N +   G TPLH A  +       +L+   AS
Sbjct: 753 SAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNAS 788



 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 52/152 (34%), Positives = 78/152 (51%), Gaps = 3/152 (1%)

Query: 28  ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
           AD +  TR       ++H A   GH ++V  LL     VN  + +G +PLH+AA   R  
Sbjct: 655 ADANAVTR---QGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVN 711

Query: 88  IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
           + + L+ +GA V+A  + G TPLH        +I   LL+  A  +AK     T +H+AA
Sbjct: 712 VAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAA 771

Query: 148 AKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
            +G+  +I++LL   AS N     GNT L +A
Sbjct: 772 QQGHTHIINVLLQNNASPNELTVNGNTALGIA 803



 Score = 82.8 bits (203), Expect = 2e-16
 Identities = 52/144 (36%), Positives = 73/144 (50%), Gaps = 1/144 (0%)

Query: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128
           K DA  S L  AA AG  E     +  G  +N  NQNG   LH A+ +   E+   LL+ 
Sbjct: 38  KSDANASYLR-AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQR 96

Query: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA 188
            AN DA      TA+H A+  G  +++ +L+   A+ N Q   G TPL++A  E  +E  
Sbjct: 97  EANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVV 156

Query: 189 KLLVSQGASIYIENKEEKTPLQVA 212
           K L+  GAS  +  ++  TPL VA
Sbjct: 157 KFLLDNGASQSLATEDGFTPLAVA 180



 Score = 80.9 bits (198), Expect = 8e-16
 Identities = 59/224 (26%), Positives = 96/224 (42%), Gaps = 29/224 (12%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+ + ++ + +      Q+  T L+ A    H E+V+FLL  G   +   + G++PL +A
Sbjct: 121 EVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA 180

Query: 81  ASAGRDEIVKALLG---------------------KGAQVNAVNQN--------GCTPLH 111
              G D++V  LL                      K A +   N N        G TPLH
Sbjct: 181 LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLH 240

Query: 112 YAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTE 171
            AA      +A +LL   A  D     + T +H A+ +GN  M+ +LL   A  + +  +
Sbjct: 241 IAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRD 300

Query: 172 GNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
           G TPLH        +  ++L+ + A I  + K   +PL +A  G
Sbjct: 301 GLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQG 344



 Score = 80.1 bits (196), Expect = 1e-15
 Identities = 51/170 (30%), Positives = 81/170 (47%)

Query: 43  ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           ALH A     T+    LLQ     + +  +G++PLHIAA  G   +   LL + A V+  
Sbjct: 205 ALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFT 264

Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
            +N  TPLH A+ +    +  +LL+ GA  DAK     T +H  A  G+ +++ +LL   
Sbjct: 265 ARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRA 324

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A    +   G +PLH+A   + +   +LL+     +     +  T L VA
Sbjct: 325 APILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVA 374



 Score = 72.0 bits (175), Expect = 4e-13
 Identities = 54/182 (29%), Positives = 84/182 (46%), Gaps = 15/182 (8%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           +++   T LH A       + E L+  G  V+ +   G++PLH+    G  +IV  LL  
Sbjct: 693 SNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQH 752

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
            A+VNA  +NG TPLH AA +    I  +LL+  A+P+       TA+  A   G + ++
Sbjct: 753 SAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVV 812

Query: 156 HIL------------LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENK 203
             L            +  K   N+ +T  N  L ++ DE R   A  ++S G   YI + 
Sbjct: 813 DTLKIVTEETMTTTTVTEKHKMNVPETM-NEVLDMSDDEVRKANAPEMLSDGE--YISDV 869

Query: 204 EE 205
           EE
Sbjct: 870 EE 871


>gi|188595682 ankyrin 2 isoform 3 [Homo sapiens]
          Length = 1863

 Score =  115 bits (287), Expect = 4e-26
 Identities = 63/171 (36%), Positives = 95/171 (55%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH +   G  ++   LL+ G   +     G++PLH+AA  G  ++ K LL + A  ++
Sbjct: 511 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 570

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             +NG TPLH AA  +  ++A++LLE GA+P A      T +H AA K  +++   LL Y
Sbjct: 571 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 630

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A TNI   +G TPLHLA  E   +   LL+ +GA+I++  K   T L +A
Sbjct: 631 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 681



 Score =  113 bits (283), Expect = 1e-25
 Identities = 71/193 (36%), Positives = 107/193 (55%), Gaps = 2/193 (1%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T ++  T LH A   G+T +V+ LL  G  ++ K   G +PLH AA +G D++V+ LL +
Sbjct: 241 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 300

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA + A  +NG +PLH AA  +  E    LL+  A  D       TA+H AA  G+ ++ 
Sbjct: 301 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT 360

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA--K 213
            +LL  +A+ N +   G TPLH+AC + R++  +LLV  GASI    +   TP+ VA   
Sbjct: 361 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 420

Query: 214 GGLGLILKRMVEG 226
           G L ++L  +  G
Sbjct: 421 GHLNIVLLLLQNG 433



 Score =  107 bits (268), Expect = 6e-24
 Identities = 67/181 (37%), Positives = 97/181 (53%), Gaps = 1/181 (0%)

Query: 32  LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
           L  RT ++  + LH A    H E V+ LLQ   PV+D      + LH+AA  G   + K 
Sbjct: 304 LLART-KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 362

Query: 92  LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151
           LL K A  NA   NG TPLH A  KNR ++  +L++ GA+  A      T +H AA  G+
Sbjct: 363 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 422

Query: 152 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211
           L ++ +LL   AS ++ +  G T LH+A    +VE  + L+  GA +    +EE+TPL +
Sbjct: 423 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 482

Query: 212 A 212
           A
Sbjct: 483 A 483



 Score =  106 bits (265), Expect = 1e-23
 Identities = 60/171 (35%), Positives = 92/171 (53%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC     +++E L++ G  +    ++G +P+H+AA  G   IV  LL  GA  + 
Sbjct: 379 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 438

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N  G T LH AA   + E+   LL  GA  DA+   E T +H A+  G  +++ +LL +
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A  +   T G TPLH++  E +V+ A +L+  GA+  +  K+  TPL VA
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 549



 Score =  106 bits (265), Expect = 1e-23
 Identities = 66/177 (37%), Positives = 96/177 (54%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T+    TALH A  AG  E+V  LL+ G  V+ +     +PLHIA+  G+ EIV+ LL  
Sbjct: 439 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 498

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
            A  +A   NG TPLH +A + + ++A +LLE GA          T +H AA  G+L + 
Sbjct: 499 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 558

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL  +A+ +     G TPLH+A   +  + A LL+ +GAS +   K   TPL +A
Sbjct: 559 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 615



 Score =  105 bits (261), Expect = 4e-23
 Identities = 77/244 (31%), Positives = 113/244 (46%), Gaps = 38/244 (15%)

Query: 6   SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
           SN      A +G L+++ E +     + T  +Q+   ALH A   GH  +V+ LL  G  
Sbjct: 10  SNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGSS 68

Query: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
           V+     G + LHIA+ AG+ E+VK L+ +GA +NA +QNG TPL+ AA +N  ++   L
Sbjct: 69  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 128

Query: 126 LEGGANP-----------------------------DAKDHYEATAMHRAAAKGNLKMIH 156
           LE GAN                              D K      A+H AA K + K   
Sbjct: 129 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 188

Query: 157 ILLYYKASTNIQD--------TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTP 208
           +LL    + ++Q           G TPLH+A     V  A LL+++GA++    +   TP
Sbjct: 189 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 248

Query: 209 LQVA 212
           L VA
Sbjct: 249 LHVA 252



 Score =  102 bits (255), Expect = 2e-22
 Identities = 67/185 (36%), Positives = 93/185 (50%), Gaps = 3/185 (1%)

Query: 28  ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
           A  SLAT+      T LH A   G  ++ + LLQ     +     G +PLH+AA     +
Sbjct: 533 AAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 589

Query: 88  IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
           +   LL KGA  +A  +NG TPLH AA KN+ +IA  LL  GA  +       T +H A+
Sbjct: 590 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 649

Query: 148 AKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKT 207
            +G+  M+ +LL   A+ ++    G T LHLA  E++V  A +L   GA      K   T
Sbjct: 650 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 709

Query: 208 PLQVA 212
           PL VA
Sbjct: 710 PLIVA 714



 Score = 98.6 bits (244), Expect = 4e-21
 Identities = 63/171 (36%), Positives = 94/171 (54%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T +H A   GH  IV  LLQ G   +  +  G + LH+AA AG+ E+V+ LL  GA V+A
Sbjct: 412 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 471

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             +   TPLH A+   + EI  +LL+  A+PDA      T +H +A +G + +  +LL  
Sbjct: 472 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 531

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A+ ++   +G TPLH+A     ++ AKLL+ + A+     K   TPL VA
Sbjct: 532 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 582



 Score = 96.7 bits (239), Expect = 1e-20
 Identities = 57/192 (29%), Positives = 95/192 (49%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           ++ + +L  ++ A    ++  T LH A    + ++   LL+ G   +     G++PLHIA
Sbjct: 556 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 615

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A   + +I   LL  GA+ N V + G TPLH A+ +   ++  +LL+ GAN         
Sbjct: 616 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 675

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI 200
           T++H AA +  + +  IL  + A  +     G TPL +AC    V+    L+ QGA++  
Sbjct: 676 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 735

Query: 201 ENKEEKTPLQVA 212
           + K   TPL  A
Sbjct: 736 KTKNGYTPLHQA 747



 Score = 94.7 bits (234), Expect = 6e-20
 Identities = 57/178 (32%), Positives = 86/178 (48%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T ++  T LH A      +I   LL  G   N     G +PLH+A+  G  ++V  LL K
Sbjct: 604 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 663

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA ++   ++G T LH AA +++  +A +L + GA+ DA      T +  A   GN+KM+
Sbjct: 664 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 723

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
           + LL   A+ N +   G TPLH A  +       +L+  GA          T L +AK
Sbjct: 724 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 781



 Score = 85.5 bits (210), Expect = 3e-17
 Identities = 58/178 (32%), Positives = 86/178 (48%), Gaps = 8/178 (4%)

Query: 43  ALHWACSAGHTEIVEFLLQLG--------VPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
           ALH A     T+    LLQ          + VN   ++G++PLHIAA  G   +   LL 
Sbjct: 174 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 233

Query: 95  KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKM 154
           +GA V+   +NG TPLH A+ +    +  +LL+ G   DAK     T +H AA  G+ ++
Sbjct: 234 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 293

Query: 155 IHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +LL   A    +   G +PLH+A   + VE  K L+   A +     +  T L VA
Sbjct: 294 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 351



 Score = 79.0 bits (193), Expect = 3e-15
 Identities = 58/237 (24%), Positives = 100/237 (42%), Gaps = 38/237 (16%)

Query: 16  SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS 75
           +G+ E +K  +    ++  ++ Q+  T L+ A    H ++V++LL+ G   +   + G++
Sbjct: 86  AGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 144

Query: 76  PLHIAASAGRDEIVKALLGKGAQ------------------------------------- 98
           PL +A   G ++ V  LL    +                                     
Sbjct: 145 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 204

Query: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
           VN   ++G TPLH AA      +A +LL  GA  D       T +H A+ +GN  M+ +L
Sbjct: 205 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 264

Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
           L      + +  +G TPLH A      +  +LL+ +GA +    K   +PL +A  G
Sbjct: 265 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 321



 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 39/117 (33%), Positives = 59/117 (50%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T+LH A       + + L + G   +     G++PL +A   G  ++V  LL +GA VNA
Sbjct: 676 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 735

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
             +NG TPLH AA +    I  +LL+ GA P+A      TA+  A   G + ++  L
Sbjct: 736 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 792


>gi|52426737 ankyrin 2 isoform 2 [Homo sapiens]
          Length = 1872

 Score =  115 bits (287), Expect = 4e-26
 Identities = 63/171 (36%), Positives = 95/171 (55%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH +   G  ++   LL+ G   +     G++PLH+AA  G  ++ K LL + A  ++
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             +NG TPLH AA  +  ++A++LLE GA+P A      T +H AA K  +++   LL Y
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A TNI   +G TPLHLA  E   +   LL+ +GA+I++  K   T L +A
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702



 Score =  113 bits (283), Expect = 1e-25
 Identities = 71/193 (36%), Positives = 107/193 (55%), Gaps = 2/193 (1%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T ++  T LH A   G+T +V+ LL  G  ++ K   G +PLH AA +G D++V+ LL +
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA + A  +NG +PLH AA  +  E    LL+  A  D       TA+H AA  G+ ++ 
Sbjct: 322 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT 381

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA--K 213
            +LL  +A+ N +   G TPLH+AC + R++  +LLV  GASI    +   TP+ VA   
Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 214 GGLGLILKRMVEG 226
           G L ++L  +  G
Sbjct: 442 GHLNIVLLLLQNG 454



 Score =  107 bits (268), Expect = 6e-24
 Identities = 67/181 (37%), Positives = 97/181 (53%), Gaps = 1/181 (0%)

Query: 32  LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
           L  RT ++  + LH A    H E V+ LLQ   PV+D      + LH+AA  G   + K 
Sbjct: 325 LLART-KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383

Query: 92  LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151
           LL K A  NA   NG TPLH A  KNR ++  +L++ GA+  A      T +H AA  G+
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443

Query: 152 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211
           L ++ +LL   AS ++ +  G T LH+A    +VE  + L+  GA +    +EE+TPL +
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503

Query: 212 A 212
           A
Sbjct: 504 A 504



 Score =  106 bits (265), Expect = 1e-23
 Identities = 60/171 (35%), Positives = 92/171 (53%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC     +++E L++ G  +    ++G +P+H+AA  G   IV  LL  GA  + 
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N  G T LH AA   + E+   LL  GA  DA+   E T +H A+  G  +++ +LL +
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A  +   T G TPLH++  E +V+ A +L+  GA+  +  K+  TPL VA
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570



 Score =  106 bits (265), Expect = 1e-23
 Identities = 66/177 (37%), Positives = 96/177 (54%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T+    TALH A  AG  E+V  LL+ G  V+ +     +PLHIA+  G+ EIV+ LL  
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
            A  +A   NG TPLH +A + + ++A +LLE GA          T +H AA  G+L + 
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL  +A+ +     G TPLH+A   +  + A LL+ +GAS +   K   TPL +A
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636



 Score =  105 bits (261), Expect = 4e-23
 Identities = 77/244 (31%), Positives = 113/244 (46%), Gaps = 38/244 (15%)

Query: 6   SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
           SN      A +G L+++ E +     + T  +Q+   ALH A   GH  +V+ LL  G  
Sbjct: 31  SNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
           V+     G + LHIA+ AG+ E+VK L+ +GA +NA +QNG TPL+ AA +N  ++   L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 126 LEGGANP-----------------------------DAKDHYEATAMHRAAAKGNLKMIH 156
           LE GAN                              D K      A+H AA K + K   
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209

Query: 157 ILLYYKASTNIQD--------TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTP 208
           +LL    + ++Q           G TPLH+A     V  A LL+++GA++    +   TP
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 209 LQVA 212
           L VA
Sbjct: 270 LHVA 273



 Score =  102 bits (255), Expect = 2e-22
 Identities = 67/185 (36%), Positives = 93/185 (50%), Gaps = 3/185 (1%)

Query: 28  ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
           A  SLAT+      T LH A   G  ++ + LLQ     +     G +PLH+AA     +
Sbjct: 554 AAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610

Query: 88  IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
           +   LL KGA  +A  +NG TPLH AA KN+ +IA  LL  GA  +       T +H A+
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670

Query: 148 AKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKT 207
            +G+  M+ +LL   A+ ++    G T LHLA  E++V  A +L   GA      K   T
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730

Query: 208 PLQVA 212
           PL VA
Sbjct: 731 PLIVA 735



 Score = 98.6 bits (244), Expect = 4e-21
 Identities = 63/171 (36%), Positives = 94/171 (54%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T +H A   GH  IV  LLQ G   +  +  G + LH+AA AG+ E+V+ LL  GA V+A
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             +   TPLH A+   + EI  +LL+  A+PDA      T +H +A +G + +  +LL  
Sbjct: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A+ ++   +G TPLH+A     ++ AKLL+ + A+     K   TPL VA
Sbjct: 553 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603



 Score = 96.7 bits (239), Expect = 1e-20
 Identities = 57/192 (29%), Positives = 95/192 (49%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           ++ + +L  ++ A    ++  T LH A    + ++   LL+ G   +     G++PLHIA
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A   + +I   LL  GA+ N V + G TPLH A+ +   ++  +LL+ GAN         
Sbjct: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI 200
           T++H AA +  + +  IL  + A  +     G TPL +AC    V+    L+ QGA++  
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756

Query: 201 ENKEEKTPLQVA 212
           + K   TPL  A
Sbjct: 757 KTKNGYTPLHQA 768



 Score = 94.7 bits (234), Expect = 6e-20
 Identities = 57/178 (32%), Positives = 86/178 (48%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T ++  T LH A      +I   LL  G   N     G +PLH+A+  G  ++V  LL K
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA ++   ++G T LH AA +++  +A +L + GA+ DA      T +  A   GN+KM+
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
           + LL   A+ N +   G TPLH A  +       +L+  GA          T L +AK
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802



 Score = 85.5 bits (210), Expect = 3e-17
 Identities = 58/178 (32%), Positives = 86/178 (48%), Gaps = 8/178 (4%)

Query: 43  ALHWACSAGHTEIVEFLLQLG--------VPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
           ALH A     T+    LLQ          + VN   ++G++PLHIAA  G   +   LL 
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254

Query: 95  KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKM 154
           +GA V+   +NG TPLH A+ +    +  +LL+ G   DAK     T +H AA  G+ ++
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 314

Query: 155 IHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +LL   A    +   G +PLH+A   + VE  K L+   A +     +  T L VA
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372



 Score = 79.0 bits (193), Expect = 3e-15
 Identities = 58/237 (24%), Positives = 100/237 (42%), Gaps = 38/237 (16%)

Query: 16  SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS 75
           +G+ E +K  +    ++  ++ Q+  T L+ A    H ++V++LL+ G   +   + G++
Sbjct: 107 AGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 165

Query: 76  PLHIAASAGRDEIVKALLGKGAQ------------------------------------- 98
           PL +A   G ++ V  LL    +                                     
Sbjct: 166 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 225

Query: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
           VN   ++G TPLH AA      +A +LL  GA  D       T +H A+ +GN  M+ +L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285

Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
           L      + +  +G TPLH A      +  +LL+ +GA +    K   +PL +A  G
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342



 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 39/117 (33%), Positives = 59/117 (50%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T+LH A       + + L + G   +     G++PL +A   G  ++V  LL +GA VNA
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
             +NG TPLH AA +    I  +LL+ GA P+A      TA+  A   G + ++  L
Sbjct: 757 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813


>gi|52426735 ankyrin 2 isoform 1 [Homo sapiens]
          Length = 3957

 Score =  115 bits (287), Expect = 4e-26
 Identities = 63/171 (36%), Positives = 95/171 (55%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH +   G  ++   LL+ G   +     G++PLH+AA  G  ++ K LL + A  ++
Sbjct: 532 TPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADS 591

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             +NG TPLH AA  +  ++A++LLE GA+P A      T +H AA K  +++   LL Y
Sbjct: 592 AGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNY 651

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A TNI   +G TPLHLA  E   +   LL+ +GA+I++  K   T L +A
Sbjct: 652 GAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGLTSLHLA 702



 Score =  113 bits (283), Expect = 1e-25
 Identities = 71/193 (36%), Positives = 107/193 (55%), Gaps = 2/193 (1%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T ++  T LH A   G+T +V+ LL  G  ++ K   G +PLH AA +G D++V+ LL +
Sbjct: 262 TARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLER 321

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA + A  +NG +PLH AA  +  E    LL+  A  D       TA+H AA  G+ ++ 
Sbjct: 322 GAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVT 381

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA--K 213
            +LL  +A+ N +   G TPLH+AC + R++  +LLV  GASI    +   TP+ VA   
Sbjct: 382 KLLLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFM 441

Query: 214 GGLGLILKRMVEG 226
           G L ++L  +  G
Sbjct: 442 GHLNIVLLLLQNG 454



 Score =  107 bits (268), Expect = 6e-24
 Identities = 67/181 (37%), Positives = 97/181 (53%), Gaps = 1/181 (0%)

Query: 32  LATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKA 91
           L  RT ++  + LH A    H E V+ LLQ   PV+D      + LH+AA  G   + K 
Sbjct: 325 LLART-KNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVAAHCGHYRVTKL 383

Query: 92  LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151
           LL K A  NA   NG TPLH A  KNR ++  +L++ GA+  A      T +H AA  G+
Sbjct: 384 LLDKRANPNARALNGFTPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGH 443

Query: 152 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211
           L ++ +LL   AS ++ +  G T LH+A    +VE  + L+  GA +    +EE+TPL +
Sbjct: 444 LNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHI 503

Query: 212 A 212
           A
Sbjct: 504 A 504



 Score =  106 bits (265), Expect = 1e-23
 Identities = 60/171 (35%), Positives = 92/171 (53%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC     +++E L++ G  +    ++G +P+H+AA  G   IV  LL  GA  + 
Sbjct: 400 TPLHIACKKNRIKVMELLVKYGASIQAITESGLTPIHVAAFMGHLNIVLLLLQNGASPDV 459

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N  G T LH AA   + E+   LL  GA  DA+   E T +H A+  G  +++ +LL +
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A  +   T G TPLH++  E +V+ A +L+  GA+  +  K+  TPL VA
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVA 570



 Score =  106 bits (265), Expect = 1e-23
 Identities = 66/177 (37%), Positives = 96/177 (54%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T+    TALH A  AG  E+V  LL+ G  V+ +     +PLHIA+  G+ EIV+ LL  
Sbjct: 460 TNIRGETALHMAARAGQVEVVRCLLRNGALVDARAREEQTPLHIASRLGKTEIVQLLLQH 519

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
            A  +A   NG TPLH +A + + ++A +LLE GA          T +H AA  G+L + 
Sbjct: 520 MAHPDAATTNGYTPLHISAREGQVDVASVLLEAGAAHSLATKKGFTPLHVAAKYGSLDVA 579

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL  +A+ +     G TPLH+A   +  + A LL+ +GAS +   K   TPL +A
Sbjct: 580 KLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636



 Score =  105 bits (261), Expect = 4e-23
 Identities = 77/244 (31%), Positives = 113/244 (46%), Gaps = 38/244 (15%)

Query: 6   SNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP 65
           SN      A +G L+++ E +     + T  +Q+   ALH A   GH  +V+ LL  G  
Sbjct: 31  SNASFLRAARAGNLDKVVEYLKGGIDINT-CNQNGLNALHLAAKEGHVGLVQELLGRGSS 89

Query: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
           V+     G + LHIA+ AG+ E+VK L+ +GA +NA +QNG TPL+ AA +N  ++   L
Sbjct: 90  VDSATKKGNTALHIASLAGQAEVVKVLVKEGANINAQSQNGFTPLYMAAQENHIDVVKYL 149

Query: 126 LEGGANP-----------------------------DAKDHYEATAMHRAAAKGNLKMIH 156
           LE GAN                              D K      A+H AA K + K   
Sbjct: 150 LENGANQSTATEDGFTPLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAA 209

Query: 157 ILLYYKASTNIQD--------TEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTP 208
           +LL    + ++Q           G TPLH+A     V  A LL+++GA++    +   TP
Sbjct: 210 LLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITP 269

Query: 209 LQVA 212
           L VA
Sbjct: 270 LHVA 273



 Score =  102 bits (255), Expect = 2e-22
 Identities = 67/185 (36%), Positives = 93/185 (50%), Gaps = 3/185 (1%)

Query: 28  ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDE 87
           A  SLAT+      T LH A   G  ++ + LLQ     +     G +PLH+AA     +
Sbjct: 554 AAHSLATKK---GFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQK 610

Query: 88  IVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
           +   LL KGA  +A  +NG TPLH AA KN+ +IA  LL  GA  +       T +H A+
Sbjct: 611 VALLLLEKGASPHATAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLAS 670

Query: 148 AKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKT 207
            +G+  M+ +LL   A+ ++    G T LHLA  E++V  A +L   GA      K   T
Sbjct: 671 QEGHTDMVTLLLDKGANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYT 730

Query: 208 PLQVA 212
           PL VA
Sbjct: 731 PLIVA 735



 Score = 98.6 bits (244), Expect = 4e-21
 Identities = 63/171 (36%), Positives = 94/171 (54%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T +H A   GH  IV  LLQ G   +  +  G + LH+AA AG+ E+V+ LL  GA V+A
Sbjct: 433 TPIHVAAFMGHLNIVLLLLQNGASPDVTNIRGETALHMAARAGQVEVVRCLLRNGALVDA 492

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             +   TPLH A+   + EI  +LL+  A+PDA      T +H +A +G + +  +LL  
Sbjct: 493 RAREEQTPLHIASRLGKTEIVQLLLQHMAHPDAATTNGYTPLHISAREGQVDVASVLLEA 552

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A+ ++   +G TPLH+A     ++ AKLL+ + A+     K   TPL VA
Sbjct: 553 GAAHSLATKKGFTPLHVAAKYGSLDVAKLLLQRRAAADSAGKNGLTPLHVA 603



 Score = 96.7 bits (239), Expect = 1e-20
 Identities = 57/192 (29%), Positives = 95/192 (49%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           ++ + +L  ++ A    ++  T LH A    + ++   LL+ G   +     G++PLHIA
Sbjct: 577 DVAKLLLQRRAAADSAGKNGLTPLHVAAHYDNQKVALLLLEKGASPHATAKNGYTPLHIA 636

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A   + +I   LL  GA+ N V + G TPLH A+ +   ++  +LL+ GAN         
Sbjct: 637 AKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDKGANIHMSTKSGL 696

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI 200
           T++H AA +  + +  IL  + A  +     G TPL +AC    V+    L+ QGA++  
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756

Query: 201 ENKEEKTPLQVA 212
           + K   TPL  A
Sbjct: 757 KTKNGYTPLHQA 768



 Score = 94.7 bits (234), Expect = 6e-20
 Identities = 57/178 (32%), Positives = 86/178 (48%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T ++  T LH A      +I   LL  G   N     G +PLH+A+  G  ++V  LL K
Sbjct: 625 TAKNGYTPLHIAAKKNQMQIASTLLNYGAETNIVTKQGVTPLHLASQEGHTDMVTLLLDK 684

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA ++   ++G T LH AA +++  +A +L + GA+ DA      T +  A   GN+KM+
Sbjct: 685 GANIHMSTKSGLTSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMV 744

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
           + LL   A+ N +   G TPLH A  +       +L+  GA          T L +AK
Sbjct: 745 NFLLKQGANVNAKTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAK 802



 Score = 85.5 bits (210), Expect = 3e-17
 Identities = 58/178 (32%), Positives = 86/178 (48%), Gaps = 8/178 (4%)

Query: 43  ALHWACSAGHTEIVEFLLQLG--------VPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
           ALH A     T+    LLQ          + VN   ++G++PLHIAA  G   +   LL 
Sbjct: 195 ALHIAARKDDTKSAALLLQNDHNADVQSKMMVNRTTESGFTPLHIAAHYGNVNVATLLLN 254

Query: 95  KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKM 154
           +GA V+   +NG TPLH A+ +    +  +LL+ G   DAK     T +H AA  G+ ++
Sbjct: 255 RGAAVDFTARNGITPLHVASKRGNTNMVKLLLDRGGQIDAKTRDGLTPLHCAARSGHDQV 314

Query: 155 IHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +LL   A    +   G +PLH+A   + VE  K L+   A +     +  T L VA
Sbjct: 315 VELLLERGAPLLARTKNGLSPLHMAAQGDHVECVKHLLQHKAPVDDVTLDYLTALHVA 372



 Score = 79.0 bits (193), Expect = 3e-15
 Identities = 58/237 (24%), Positives = 100/237 (42%), Gaps = 38/237 (16%)

Query: 16  SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS 75
           +G+ E +K  +    ++  ++ Q+  T L+ A    H ++V++LL+ G   +   + G++
Sbjct: 107 AGQAEVVKVLVKEGANINAQS-QNGFTPLYMAAQENHIDVVKYLLENGANQSTATEDGFT 165

Query: 76  PLHIAASAGRDEIVKALLGKGAQ------------------------------------- 98
           PL +A   G ++ V  LL    +                                     
Sbjct: 166 PLAVALQQGHNQAVAILLENDTKGKVRLPALHIAARKDDTKSAALLLQNDHNADVQSKMM 225

Query: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
           VN   ++G TPLH AA      +A +LL  GA  D       T +H A+ +GN  M+ +L
Sbjct: 226 VNRTTESGFTPLHIAAHYGNVNVATLLLNRGAAVDFTARNGITPLHVASKRGNTNMVKLL 285

Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
           L      + +  +G TPLH A      +  +LL+ +GA +    K   +PL +A  G
Sbjct: 286 LDRGGQIDAKTRDGLTPLHCAARSGHDQVVELLLERGAPLLARTKNGLSPLHMAAQG 342



 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 39/117 (33%), Positives = 59/117 (50%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T+LH A       + + L + G   +     G++PL +A   G  ++V  LL +GA VNA
Sbjct: 697 TSLHLAAQEDKVNVADILTKHGADQDAHTKLGYTPLIVACHYGNVKMVNFLLKQGANVNA 756

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
             +NG TPLH AA +    I  +LL+ GA P+A      TA+  A   G + ++  L
Sbjct: 757 KTKNGYTPLHQAAQQGHTHIINVLLQHGAKPNATTANGNTALAIAKRLGYISVVDTL 813


>gi|215598574 ankyrin 1 isoform 9 [Homo sapiens]
          Length = 1897

 Score =  114 bits (286), Expect = 5e-26
 Identities = 67/171 (39%), Positives = 93/171 (54%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC   H  ++E LL+ G  ++   ++G +PLH+A+  G   IVK LL +GA  N 
Sbjct: 406 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 465

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N    TPLH AA     E+A  LL+  A  +AK   + T +H AA  G+  M+ +LL  
Sbjct: 466 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 525

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A+ N+  T G+TPLH+A  E  VE    L+ + AS     K+  TPL VA
Sbjct: 526 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 576



 Score =  114 bits (286), Expect = 5e-26
 Identities = 75/211 (35%), Positives = 109/211 (51%), Gaps = 3/211 (1%)

Query: 5   VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
           VSN+ V    ++A      E+ + +L +K+      +D +T LH A   GHT +V+ LL+
Sbjct: 465 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 524

Query: 62  LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
                N    AG +PLHIAA  G  E V ALL K A    + + G TPLH AA   +  +
Sbjct: 525 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 584

Query: 122 AVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACD 181
           A +LLE  A+P+A      T +H A    NL ++ +LL    S +     G TPLH+A  
Sbjct: 585 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 644

Query: 182 EERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +VE A+ L+  G S   E+ +  TPL +A
Sbjct: 645 QNQVEVARSLLQYGGSANAESVQGVTPLHLA 675



 Score =  108 bits (270), Expect = 4e-24
 Identities = 61/169 (36%), Positives = 89/169 (52%)

Query: 44  LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
           +H A    H + V  LLQ    ++D      +PLH+AA  G   + K LL KGA+ N+  
Sbjct: 342 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 401

Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163
            NG TPLH A  KN   +  +LL+ GA+ DA      T +H A+  G+L ++  LL   A
Sbjct: 402 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 461

Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           S N+ + +  TPLH+A      E AK L+   A +  + K+++TPL  A
Sbjct: 462 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 510



 Score =  106 bits (265), Expect = 1e-23
 Identities = 64/188 (34%), Positives = 99/188 (52%), Gaps = 1/188 (0%)

Query: 26  ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
           +L D+     T  +D  T LH A   GH  I E LL  G P+  K   G SP+H+AA   
Sbjct: 290 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 349

Query: 85  RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
             + V+ LL   A+++ +  +  TPLH AA    H +A +LL+ GA P+++     T +H
Sbjct: 350 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 409

Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
            A  K +++++ +LL   AS +     G TPLH+A     +   K L+ +GAS  + N +
Sbjct: 410 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 469

Query: 205 EKTPLQVA 212
            +TPL +A
Sbjct: 470 VETPLHMA 477



 Score =  105 bits (262), Expect = 3e-23
 Identities = 67/199 (33%), Positives = 101/199 (50%), Gaps = 1/199 (0%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A  G +E +   +  + S A  T +   T LH A   G   + E LL+     N     G
Sbjct: 544 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 602

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            +PLH+A      +IVK LL +G   ++   NG TPLH AA +N+ E+A  LL+ G + +
Sbjct: 603 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 662

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           A+     T +H AA +G+ +M+ +LL  +A+ N+ +  G TPLHL   E  V  A +L+ 
Sbjct: 663 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 722

Query: 194 QGASIYIENKEEKTPLQVA 212
            G  +    +   TPL VA
Sbjct: 723 HGVMVDATTRMGYTPLHVA 741



 Score =  105 bits (261), Expect = 4e-23
 Identities = 61/172 (35%), Positives = 88/172 (51%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A      E+   LLQ G   N +   G +PLH+AA  G  E+V  LL K A  N 
Sbjct: 637 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 696

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N++G TPLH  A +    +A +L++ G   DA      T +H A+  GN+K++  LL +
Sbjct: 697 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 756

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
           +A  N +   G +PLH A  +   +   LL+  GAS    + +  TPL +AK
Sbjct: 757 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 808



 Score =  103 bits (256), Expect = 2e-22
 Identities = 72/240 (30%), Positives = 113/240 (47%), Gaps = 30/240 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG L++  + +     + T  +Q+    LH A   GH ++V  LL   + +      G
Sbjct: 53  ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 111

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            + LHIAA AG+DE+V+ L+  GA VNA +Q G TPL+ AA +N  E+   LLE GAN +
Sbjct: 112 NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 171

Query: 134 A-----------------------------KDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
                                         K      A+H AA   + +   +LL    +
Sbjct: 172 VATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 231

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224
            ++    G TPLH+A   E +  A+LL+++GAS+    +   TPL +A     +I+ R++
Sbjct: 232 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 291



 Score =  100 bits (249), Expect = 1e-21
 Identities = 66/171 (38%), Positives = 90/171 (52%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A   GH  IV+ LLQ G   N  +    +PLH+AA AG  E+ K LL   A+VNA
Sbjct: 439 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 498

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             ++  TPLH AA      +  +LLE  ANP+       T +H AA +G+++ +  LL  
Sbjct: 499 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 558

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +AS      +G TPLH+A    +V  A+LL+ + A      K   TPL VA
Sbjct: 559 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 609



 Score = 99.8 bits (247), Expect = 2e-21
 Identities = 58/174 (33%), Positives = 85/174 (48%)

Query: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
           D  T LH A   GH  + + LL  G   N +   G++PLHIA       +++ LL  GA 
Sbjct: 370 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 429

Query: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
           ++AV ++G TPLH A+      I   LL+ GA+P+  +    T +H AA  G+ ++   L
Sbjct: 430 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 489

Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           L  KA  N +  +  TPLH A         KLL+   A+  +      TPL +A
Sbjct: 490 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 543



 Score = 95.1 bits (235), Expect = 4e-20
 Identities = 62/177 (35%), Positives = 87/177 (49%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T Q+  T LH A   G+  +V  LL  G  +  K     +PLH AA  G   I + LL  
Sbjct: 268 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 327

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA + A  +NG +P+H AA  +  +   +LL+  A  D       T +H AA  G+ ++ 
Sbjct: 328 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 387

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL   A  N +   G TPLH+AC +  V   +LL+  GASI    +   TPL VA
Sbjct: 388 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 444



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 57/170 (33%), Positives = 85/170 (50%)

Query: 43  ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           ALH A     T     LLQ     +     G++PLHIAA      + + LL +GA VN  
Sbjct: 209 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 268

Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
            QNG TPLH A+ +    +  +LL+ GA  + K   E T +H AA  G++++  ILL + 
Sbjct: 269 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 328

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A    +   G +P+H+A   + ++  +LL+   A I     +  TPL VA
Sbjct: 329 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 378



 Score = 82.0 bits (201), Expect = 4e-16
 Identities = 59/231 (25%), Positives = 104/231 (45%), Gaps = 30/231 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A +G+ E ++E +    ++  ++ Q   T L+ A    H E+V+FLL+ G   N   + G
Sbjct: 119 ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 177

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
           ++PL +A   G + +V  L+  G +                              + +++
Sbjct: 178 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 237

Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
            G TPLH AA      +A +LL  GA+ +       T +H A+ +GN+ M+ +LL   A 
Sbjct: 238 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 297

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
              +  +  TPLH A     V  +++L+  GA I  + K   +P+ +A  G
Sbjct: 298 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 348



 Score = 81.6 bits (200), Expect = 5e-16
 Identities = 50/159 (31%), Positives = 78/159 (49%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+  S+L     A        T LH A   GH E+V  LL      N  + +G +PLH+ 
Sbjct: 649 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 708

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A  G   +   L+  G  V+A  + G TPLH A+     ++   LL+  A+ +AK     
Sbjct: 709 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 768

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
           + +H+AA +G+  ++ +LL   AS N   ++G TPL +A
Sbjct: 769 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 807



 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 41/138 (29%), Positives = 71/138 (51%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+   +L+ ++     ++   T LH     GH  + + L++ GV V+     G++PLH+A
Sbjct: 682 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 741

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           +  G  ++VK LL   A VNA  + G +PLH AA +   +I  +LL+ GA+P+       
Sbjct: 742 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 801

Query: 141 TAMHRAAAKGNLKMIHIL 158
           T +  A   G + +  +L
Sbjct: 802 TPLAIAKRLGYISVTDVL 819



 Score = 67.4 bits (163), Expect = 9e-12
 Identities = 49/182 (26%), Positives = 88/182 (48%), Gaps = 5/182 (2%)

Query: 19  LEELKESILADKSLATRTDQ-----DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           L+E KE   +++    R+       D+ T+   A  +G+ +     L+ GV +N  +  G
Sbjct: 19  LQEQKEKEESNRKRRNRSRDRKKKADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNG 78

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            + LH+A+  G  ++V  LL K   +    + G T LH AA   + E+   L+  GAN +
Sbjct: 79  LNGLHLASKEGHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVVRELVNYGANVN 138

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           A+     T ++ AA + +L+++  LL   A+ N+   +G TPL +A  +        L++
Sbjct: 139 AQSQKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDGFTPLAVALQQGHENVVAHLIN 198

Query: 194 QG 195
            G
Sbjct: 199 YG 200



 Score = 44.3 bits (103), Expect = 9e-05
 Identities = 38/144 (26%), Positives = 60/144 (41%), Gaps = 34/144 (23%)

Query: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128
           K DA  S L  A S   D+ +  L   G  +N  NQNG   LH A+ +            
Sbjct: 42  KADAATSFLRAARSGNLDKALDHLRN-GVDINTCNQNGLNGLHLASKE------------ 88

Query: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA 188
                                G++KM+  LL+ +        +GNT LH+A    + E  
Sbjct: 89  ---------------------GHVKMVVELLHKEIILETTTKKGNTALHIAALAGQDEVV 127

Query: 189 KLLVSQGASIYIENKEEKTPLQVA 212
           + LV+ GA++  ++++  TPL +A
Sbjct: 128 RELVNYGANVNAQSQKGFTPLYMA 151


>gi|70780359 ankyrin 1 isoform 1 [Homo sapiens]
          Length = 1881

 Score =  114 bits (286), Expect = 5e-26
 Identities = 67/171 (39%), Positives = 93/171 (54%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC   H  ++E LL+ G  ++   ++G +PLH+A+  G   IVK LL +GA  N 
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N    TPLH AA     E+A  LL+  A  +AK   + T +H AA  G+  M+ +LL  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A+ N+  T G+TPLH+A  E  VE    L+ + AS     K+  TPL VA
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543



 Score =  114 bits (286), Expect = 5e-26
 Identities = 75/211 (35%), Positives = 109/211 (51%), Gaps = 3/211 (1%)

Query: 5   VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
           VSN+ V    ++A      E+ + +L +K+      +D +T LH A   GHT +V+ LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 62  LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
                N    AG +PLHIAA  G  E V ALL K A    + + G TPLH AA   +  +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 122 AVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACD 181
           A +LLE  A+P+A      T +H A    NL ++ +LL    S +     G TPLH+A  
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 182 EERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +VE A+ L+  G S   E+ +  TPL +A
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLA 642



 Score =  108 bits (270), Expect = 4e-24
 Identities = 61/169 (36%), Positives = 89/169 (52%)

Query: 44  LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
           +H A    H + V  LLQ    ++D      +PLH+AA  G   + K LL KGA+ N+  
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163
            NG TPLH A  KN   +  +LL+ GA+ DA      T +H A+  G+L ++  LL   A
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428

Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           S N+ + +  TPLH+A      E AK L+   A +  + K+++TPL  A
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477



 Score =  106 bits (265), Expect = 1e-23
 Identities = 64/188 (34%), Positives = 99/188 (52%), Gaps = 1/188 (0%)

Query: 26  ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
           +L D+     T  +D  T LH A   GH  I E LL  G P+  K   G SP+H+AA   
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316

Query: 85  RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
             + V+ LL   A+++ +  +  TPLH AA    H +A +LL+ GA P+++     T +H
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376

Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
            A  K +++++ +LL   AS +     G TPLH+A     +   K L+ +GAS  + N +
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436

Query: 205 EKTPLQVA 212
            +TPL +A
Sbjct: 437 VETPLHMA 444



 Score =  105 bits (262), Expect = 3e-23
 Identities = 67/199 (33%), Positives = 101/199 (50%), Gaps = 1/199 (0%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A  G +E +   +  + S A  T +   T LH A   G   + E LL+     N     G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            +PLH+A      +IVK LL +G   ++   NG TPLH AA +N+ E+A  LL+ G + +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           A+     T +H AA +G+ +M+ +LL  +A+ N+ +  G TPLHL   E  V  A +L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 194 QGASIYIENKEEKTPLQVA 212
            G  +    +   TPL VA
Sbjct: 690 HGVMVDATTRMGYTPLHVA 708



 Score =  105 bits (261), Expect = 4e-23
 Identities = 61/172 (35%), Positives = 88/172 (51%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A      E+   LLQ G   N +   G +PLH+AA  G  E+V  LL K A  N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N++G TPLH  A +    +A +L++ G   DA      T +H A+  GN+K++  LL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
           +A  N +   G +PLH A  +   +   LL+  GAS    + +  TPL +AK
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score =  103 bits (256), Expect = 2e-22
 Identities = 72/240 (30%), Positives = 113/240 (47%), Gaps = 30/240 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG L++  + +     + T  +Q+    LH A   GH ++V  LL   + +      G
Sbjct: 20  ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            + LHIAA AG+DE+V+ L+  GA VNA +Q G TPL+ AA +N  E+   LLE GAN +
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138

Query: 134 A-----------------------------KDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
                                         K      A+H AA   + +   +LL    +
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224
            ++    G TPLH+A   E +  A+LL+++GAS+    +   TPL +A     +I+ R++
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258



 Score =  100 bits (249), Expect = 1e-21
 Identities = 66/171 (38%), Positives = 90/171 (52%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A   GH  IV+ LLQ G   N  +    +PLH+AA AG  E+ K LL   A+VNA
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             ++  TPLH AA      +  +LLE  ANP+       T +H AA +G+++ +  LL  
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +AS      +G TPLH+A    +V  A+LL+ + A      K   TPL VA
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 99.8 bits (247), Expect = 2e-21
 Identities = 58/174 (33%), Positives = 85/174 (48%)

Query: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
           D  T LH A   GH  + + LL  G   N +   G++PLHIA       +++ LL  GA 
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
           ++AV ++G TPLH A+      I   LL+ GA+P+  +    T +H AA  G+ ++   L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           L  KA  N +  +  TPLH A         KLL+   A+  +      TPL +A
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score = 95.1 bits (235), Expect = 4e-20
 Identities = 62/177 (35%), Positives = 87/177 (49%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T Q+  T LH A   G+  +V  LL  G  +  K     +PLH AA  G   I + LL  
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA + A  +NG +P+H AA  +  +   +LL+  A  D       T +H AA  G+ ++ 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL   A  N +   G TPLH+AC +  V   +LL+  GASI    +   TPL VA
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 57/170 (33%), Positives = 85/170 (50%)

Query: 43  ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           ALH A     T     LLQ     +     G++PLHIAA      + + LL +GA VN  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
            QNG TPLH A+ +    +  +LL+ GA  + K   E T +H AA  G++++  ILL + 
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A    +   G +P+H+A   + ++  +LL+   A I     +  TPL VA
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 82.0 bits (201), Expect = 4e-16
 Identities = 59/231 (25%), Positives = 104/231 (45%), Gaps = 30/231 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A +G+ E ++E +    ++  ++ Q   T L+ A    H E+V+FLL+ G   N   + G
Sbjct: 86  ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
           ++PL +A   G + +V  L+  G +                              + +++
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
            G TPLH AA      +A +LL  GA+ +       T +H A+ +GN+ M+ +LL   A 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
              +  +  TPLH A     V  +++L+  GA I  + K   +P+ +A  G
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315



 Score = 81.6 bits (200), Expect = 5e-16
 Identities = 50/159 (31%), Positives = 78/159 (49%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+  S+L     A        T LH A   GH E+V  LL      N  + +G +PLH+ 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A  G   +   L+  G  V+A  + G TPLH A+     ++   LL+  A+ +AK     
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
           + +H+AA +G+  ++ +LL   AS N   ++G TPL +A
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 41/138 (29%), Positives = 71/138 (51%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+   +L+ ++     ++   T LH     GH  + + L++ GV V+     G++PLH+A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           +  G  ++VK LL   A VNA  + G +PLH AA +   +I  +LL+ GA+P+       
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768

Query: 141 TAMHRAAAKGNLKMIHIL 158
           T +  A   G + +  +L
Sbjct: 769 TPLAIAKRLGYISVTDVL 786



 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 44/159 (27%), Positives = 79/159 (49%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           + D+ T+   A  +G+ +     L+ GV +N  +  G + LH+A+  G  ++V  LL K 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
             +    + G T LH AA   + E+   L+  GAN +A+     T ++ AA + +L+++ 
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195
            LL   A+ N+   +G TPL +A  +        L++ G
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 27/100 (27%), Positives = 52/100 (52%)

Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172
           AA     + A+  L  G + +  +      +H A+ +G++KM+  LL+ +        +G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           NT LH+A    + E  + LV+ GA++  ++++  TPL +A
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118


>gi|70780357 ankyrin 1 isoform 3 [Homo sapiens]
          Length = 1880

 Score =  114 bits (286), Expect = 5e-26
 Identities = 67/171 (39%), Positives = 93/171 (54%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC   H  ++E LL+ G  ++   ++G +PLH+A+  G   IVK LL +GA  N 
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N    TPLH AA     E+A  LL+  A  +AK   + T +H AA  G+  M+ +LL  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A+ N+  T G+TPLH+A  E  VE    L+ + AS     K+  TPL VA
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543



 Score =  114 bits (286), Expect = 5e-26
 Identities = 75/211 (35%), Positives = 109/211 (51%), Gaps = 3/211 (1%)

Query: 5   VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
           VSN+ V    ++A      E+ + +L +K+      +D +T LH A   GHT +V+ LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 62  LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
                N    AG +PLHIAA  G  E V ALL K A    + + G TPLH AA   +  +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 122 AVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACD 181
           A +LLE  A+P+A      T +H A    NL ++ +LL    S +     G TPLH+A  
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 182 EERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +VE A+ L+  G S   E+ +  TPL +A
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLA 642



 Score =  108 bits (270), Expect = 4e-24
 Identities = 61/169 (36%), Positives = 89/169 (52%)

Query: 44  LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
           +H A    H + V  LLQ    ++D      +PLH+AA  G   + K LL KGA+ N+  
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163
            NG TPLH A  KN   +  +LL+ GA+ DA      T +H A+  G+L ++  LL   A
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428

Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           S N+ + +  TPLH+A      E AK L+   A +  + K+++TPL  A
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477



 Score =  106 bits (265), Expect = 1e-23
 Identities = 64/188 (34%), Positives = 99/188 (52%), Gaps = 1/188 (0%)

Query: 26  ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
           +L D+     T  +D  T LH A   GH  I E LL  G P+  K   G SP+H+AA   
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316

Query: 85  RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
             + V+ LL   A+++ +  +  TPLH AA    H +A +LL+ GA P+++     T +H
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376

Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
            A  K +++++ +LL   AS +     G TPLH+A     +   K L+ +GAS  + N +
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436

Query: 205 EKTPLQVA 212
            +TPL +A
Sbjct: 437 VETPLHMA 444



 Score =  105 bits (262), Expect = 3e-23
 Identities = 67/199 (33%), Positives = 101/199 (50%), Gaps = 1/199 (0%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A  G +E +   +  + S A  T +   T LH A   G   + E LL+     N     G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            +PLH+A      +IVK LL +G   ++   NG TPLH AA +N+ E+A  LL+ G + +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           A+     T +H AA +G+ +M+ +LL  +A+ N+ +  G TPLHL   E  V  A +L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 194 QGASIYIENKEEKTPLQVA 212
            G  +    +   TPL VA
Sbjct: 690 HGVMVDATTRMGYTPLHVA 708



 Score =  105 bits (261), Expect = 4e-23
 Identities = 61/172 (35%), Positives = 88/172 (51%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A      E+   LLQ G   N +   G +PLH+AA  G  E+V  LL K A  N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N++G TPLH  A +    +A +L++ G   DA      T +H A+  GN+K++  LL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
           +A  N +   G +PLH A  +   +   LL+  GAS    + +  TPL +AK
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score =  103 bits (256), Expect = 2e-22
 Identities = 72/240 (30%), Positives = 113/240 (47%), Gaps = 30/240 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG L++  + +     + T  +Q+    LH A   GH ++V  LL   + +      G
Sbjct: 20  ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            + LHIAA AG+DE+V+ L+  GA VNA +Q G TPL+ AA +N  E+   LLE GAN +
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138

Query: 134 A-----------------------------KDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
                                         K      A+H AA   + +   +LL    +
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224
            ++    G TPLH+A   E +  A+LL+++GAS+    +   TPL +A     +I+ R++
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258



 Score =  100 bits (249), Expect = 1e-21
 Identities = 66/171 (38%), Positives = 90/171 (52%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A   GH  IV+ LLQ G   N  +    +PLH+AA AG  E+ K LL   A+VNA
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             ++  TPLH AA      +  +LLE  ANP+       T +H AA +G+++ +  LL  
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +AS      +G TPLH+A    +V  A+LL+ + A      K   TPL VA
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 99.8 bits (247), Expect = 2e-21
 Identities = 58/174 (33%), Positives = 85/174 (48%)

Query: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
           D  T LH A   GH  + + LL  G   N +   G++PLHIA       +++ LL  GA 
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
           ++AV ++G TPLH A+      I   LL+ GA+P+  +    T +H AA  G+ ++   L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           L  KA  N +  +  TPLH A         KLL+   A+  +      TPL +A
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score = 95.1 bits (235), Expect = 4e-20
 Identities = 62/177 (35%), Positives = 87/177 (49%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T Q+  T LH A   G+  +V  LL  G  +  K     +PLH AA  G   I + LL  
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA + A  +NG +P+H AA  +  +   +LL+  A  D       T +H AA  G+ ++ 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL   A  N +   G TPLH+AC +  V   +LL+  GASI    +   TPL VA
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 57/170 (33%), Positives = 85/170 (50%)

Query: 43  ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           ALH A     T     LLQ     +     G++PLHIAA      + + LL +GA VN  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
            QNG TPLH A+ +    +  +LL+ GA  + K   E T +H AA  G++++  ILL + 
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A    +   G +P+H+A   + ++  +LL+   A I     +  TPL VA
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 82.0 bits (201), Expect = 4e-16
 Identities = 59/231 (25%), Positives = 104/231 (45%), Gaps = 30/231 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A +G+ E ++E +    ++  ++ Q   T L+ A    H E+V+FLL+ G   N   + G
Sbjct: 86  ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
           ++PL +A   G + +V  L+  G +                              + +++
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
            G TPLH AA      +A +LL  GA+ +       T +H A+ +GN+ M+ +LL   A 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
              +  +  TPLH A     V  +++L+  GA I  + K   +P+ +A  G
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315



 Score = 81.6 bits (200), Expect = 5e-16
 Identities = 50/159 (31%), Positives = 78/159 (49%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+  S+L     A        T LH A   GH E+V  LL      N  + +G +PLH+ 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A  G   +   L+  G  V+A  + G TPLH A+     ++   LL+  A+ +AK     
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
           + +H+AA +G+  ++ +LL   AS N   ++G TPL +A
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 41/138 (29%), Positives = 71/138 (51%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+   +L+ ++     ++   T LH     GH  + + L++ GV V+     G++PLH+A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           +  G  ++VK LL   A VNA  + G +PLH AA +   +I  +LL+ GA+P+       
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768

Query: 141 TAMHRAAAKGNLKMIHIL 158
           T +  A   G + +  +L
Sbjct: 769 TPLAIAKRLGYISVTDVL 786



 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 44/159 (27%), Positives = 79/159 (49%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           + D+ T+   A  +G+ +     L+ GV +N  +  G + LH+A+  G  ++V  LL K 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
             +    + G T LH AA   + E+   L+  GAN +A+     T ++ AA + +L+++ 
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195
            LL   A+ N+   +G TPL +A  +        L++ G
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 27/100 (27%), Positives = 52/100 (52%)

Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172
           AA     + A+  L  G + +  +      +H A+ +G++KM+  LL+ +        +G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           NT LH+A    + E  + LV+ GA++  ++++  TPL +A
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118


>gi|70780355 ankyrin 1 isoform 2 [Homo sapiens]
          Length = 1719

 Score =  114 bits (286), Expect = 5e-26
 Identities = 67/171 (39%), Positives = 93/171 (54%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC   H  ++E LL+ G  ++   ++G +PLH+A+  G   IVK LL +GA  N 
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N    TPLH AA     E+A  LL+  A  +AK   + T +H AA  G+  M+ +LL  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A+ N+  T G+TPLH+A  E  VE    L+ + AS     K+  TPL VA
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543



 Score =  114 bits (286), Expect = 5e-26
 Identities = 75/211 (35%), Positives = 109/211 (51%), Gaps = 3/211 (1%)

Query: 5   VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
           VSN+ V    ++A      E+ + +L +K+      +D +T LH A   GHT +V+ LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 62  LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
                N    AG +PLHIAA  G  E V ALL K A    + + G TPLH AA   +  +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 122 AVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACD 181
           A +LLE  A+P+A      T +H A    NL ++ +LL    S +     G TPLH+A  
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 182 EERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +VE A+ L+  G S   E+ +  TPL +A
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLA 642



 Score =  108 bits (270), Expect = 4e-24
 Identities = 61/169 (36%), Positives = 89/169 (52%)

Query: 44  LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
           +H A    H + V  LLQ    ++D      +PLH+AA  G   + K LL KGA+ N+  
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163
            NG TPLH A  KN   +  +LL+ GA+ DA      T +H A+  G+L ++  LL   A
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428

Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           S N+ + +  TPLH+A      E AK L+   A +  + K+++TPL  A
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477



 Score =  106 bits (265), Expect = 1e-23
 Identities = 64/188 (34%), Positives = 99/188 (52%), Gaps = 1/188 (0%)

Query: 26  ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
           +L D+     T  +D  T LH A   GH  I E LL  G P+  K   G SP+H+AA   
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316

Query: 85  RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
             + V+ LL   A+++ +  +  TPLH AA    H +A +LL+ GA P+++     T +H
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376

Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
            A  K +++++ +LL   AS +     G TPLH+A     +   K L+ +GAS  + N +
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436

Query: 205 EKTPLQVA 212
            +TPL +A
Sbjct: 437 VETPLHMA 444



 Score =  105 bits (262), Expect = 3e-23
 Identities = 67/199 (33%), Positives = 101/199 (50%), Gaps = 1/199 (0%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A  G +E +   +  + S A  T +   T LH A   G   + E LL+     N     G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            +PLH+A      +IVK LL +G   ++   NG TPLH AA +N+ E+A  LL+ G + +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           A+     T +H AA +G+ +M+ +LL  +A+ N+ +  G TPLHL   E  V  A +L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 194 QGASIYIENKEEKTPLQVA 212
            G  +    +   TPL VA
Sbjct: 690 HGVMVDATTRMGYTPLHVA 708



 Score =  105 bits (261), Expect = 4e-23
 Identities = 61/172 (35%), Positives = 88/172 (51%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A      E+   LLQ G   N +   G +PLH+AA  G  E+V  LL K A  N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N++G TPLH  A +    +A +L++ G   DA      T +H A+  GN+K++  LL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
           +A  N +   G +PLH A  +   +   LL+  GAS    + +  TPL +AK
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score =  103 bits (256), Expect = 2e-22
 Identities = 72/240 (30%), Positives = 113/240 (47%), Gaps = 30/240 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG L++  + +     + T  +Q+    LH A   GH ++V  LL   + +      G
Sbjct: 20  ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            + LHIAA AG+DE+V+ L+  GA VNA +Q G TPL+ AA +N  E+   LLE GAN +
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138

Query: 134 A-----------------------------KDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
                                         K      A+H AA   + +   +LL    +
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224
            ++    G TPLH+A   E +  A+LL+++GAS+    +   TPL +A     +I+ R++
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258



 Score =  100 bits (249), Expect = 1e-21
 Identities = 66/171 (38%), Positives = 90/171 (52%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A   GH  IV+ LLQ G   N  +    +PLH+AA AG  E+ K LL   A+VNA
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             ++  TPLH AA      +  +LLE  ANP+       T +H AA +G+++ +  LL  
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +AS      +G TPLH+A    +V  A+LL+ + A      K   TPL VA
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 99.8 bits (247), Expect = 2e-21
 Identities = 58/174 (33%), Positives = 85/174 (48%)

Query: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
           D  T LH A   GH  + + LL  G   N +   G++PLHIA       +++ LL  GA 
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
           ++AV ++G TPLH A+      I   LL+ GA+P+  +    T +H AA  G+ ++   L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           L  KA  N +  +  TPLH A         KLL+   A+  +      TPL +A
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score = 95.1 bits (235), Expect = 4e-20
 Identities = 62/177 (35%), Positives = 87/177 (49%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T Q+  T LH A   G+  +V  LL  G  +  K     +PLH AA  G   I + LL  
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA + A  +NG +P+H AA  +  +   +LL+  A  D       T +H AA  G+ ++ 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL   A  N +   G TPLH+AC +  V   +LL+  GASI    +   TPL VA
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 57/170 (33%), Positives = 85/170 (50%)

Query: 43  ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           ALH A     T     LLQ     +     G++PLHIAA      + + LL +GA VN  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
            QNG TPLH A+ +    +  +LL+ GA  + K   E T +H AA  G++++  ILL + 
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A    +   G +P+H+A   + ++  +LL+   A I     +  TPL VA
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 82.0 bits (201), Expect = 4e-16
 Identities = 59/231 (25%), Positives = 104/231 (45%), Gaps = 30/231 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A +G+ E ++E +    ++  ++ Q   T L+ A    H E+V+FLL+ G   N   + G
Sbjct: 86  ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
           ++PL +A   G + +V  L+  G +                              + +++
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
            G TPLH AA      +A +LL  GA+ +       T +H A+ +GN+ M+ +LL   A 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
              +  +  TPLH A     V  +++L+  GA I  + K   +P+ +A  G
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315



 Score = 81.6 bits (200), Expect = 5e-16
 Identities = 50/159 (31%), Positives = 78/159 (49%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+  S+L     A        T LH A   GH E+V  LL      N  + +G +PLH+ 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A  G   +   L+  G  V+A  + G TPLH A+     ++   LL+  A+ +AK     
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
           + +H+AA +G+  ++ +LL   AS N   ++G TPL +A
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 41/138 (29%), Positives = 71/138 (51%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+   +L+ ++     ++   T LH     GH  + + L++ GV V+     G++PLH+A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           +  G  ++VK LL   A VNA  + G +PLH AA +   +I  +LL+ GA+P+       
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768

Query: 141 TAMHRAAAKGNLKMIHIL 158
           T +  A   G + +  +L
Sbjct: 769 TPLAIAKRLGYISVTDVL 786



 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 44/159 (27%), Positives = 79/159 (49%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           + D+ T+   A  +G+ +     L+ GV +N  +  G + LH+A+  G  ++V  LL K 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
             +    + G T LH AA   + E+   L+  GAN +A+     T ++ AA + +L+++ 
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195
            LL   A+ N+   +G TPL +A  +        L++ G
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 27/100 (27%), Positives = 52/100 (52%)

Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172
           AA     + A+  L  G + +  +      +H A+ +G++KM+  LL+ +        +G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           NT LH+A    + E  + LV+ GA++  ++++  TPL +A
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118


>gi|70780353 ankyrin 1 isoform 4 [Homo sapiens]
          Length = 1856

 Score =  114 bits (286), Expect = 5e-26
 Identities = 67/171 (39%), Positives = 93/171 (54%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH AC   H  ++E LL+ G  ++   ++G +PLH+A+  G   IVK LL +GA  N 
Sbjct: 373 TPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNV 432

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N    TPLH AA     E+A  LL+  A  +AK   + T +H AA  G+  M+ +LL  
Sbjct: 433 SNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLEN 492

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            A+ N+  T G+TPLH+A  E  VE    L+ + AS     K+  TPL VA
Sbjct: 493 NANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVA 543



 Score =  114 bits (286), Expect = 5e-26
 Identities = 75/211 (35%), Positives = 109/211 (51%), Gaps = 3/211 (1%)

Query: 5   VSNLMV---CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ 61
           VSN+ V    ++A      E+ + +L +K+      +D +T LH A   GHT +V+ LL+
Sbjct: 432 VSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLE 491

Query: 62  LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
                N    AG +PLHIAA  G  E V ALL K A    + + G TPLH AA   +  +
Sbjct: 492 NNANPNLATTAGHTPLHIAAREGHVETVLALLEKEASQACMTKKGFTPLHVAAKYGKVRV 551

Query: 122 AVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACD 181
           A +LLE  A+P+A      T +H A    NL ++ +LL    S +     G TPLH+A  
Sbjct: 552 AELLLERDAHPNAAGKNGLTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAK 611

Query: 182 EERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +VE A+ L+  G S   E+ +  TPL +A
Sbjct: 612 QNQVEVARSLLQYGGSANAESVQGVTPLHLA 642



 Score =  108 bits (270), Expect = 4e-24
 Identities = 61/169 (36%), Positives = 89/169 (52%)

Query: 44  LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVN 103
           +H A    H + V  LLQ    ++D      +PLH+AA  G   + K LL KGA+ N+  
Sbjct: 309 IHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRA 368

Query: 104 QNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKA 163
            NG TPLH A  KN   +  +LL+ GA+ DA      T +H A+  G+L ++  LL   A
Sbjct: 369 LNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGA 428

Query: 164 STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           S N+ + +  TPLH+A      E AK L+   A +  + K+++TPL  A
Sbjct: 429 SPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNAKAKDDQTPLHCA 477



 Score =  106 bits (265), Expect = 1e-23
 Identities = 64/188 (34%), Positives = 99/188 (52%), Gaps = 1/188 (0%)

Query: 26  ILADKSLATRTD-QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
           +L D+     T  +D  T LH A   GH  I E LL  G P+  K   G SP+H+AA   
Sbjct: 257 LLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQGD 316

Query: 85  RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
             + V+ LL   A+++ +  +  TPLH AA    H +A +LL+ GA P+++     T +H
Sbjct: 317 HLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLH 376

Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
            A  K +++++ +LL   AS +     G TPLH+A     +   K L+ +GAS  + N +
Sbjct: 377 IACKKNHVRVMELLLKTGASIDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVK 436

Query: 205 EKTPLQVA 212
            +TPL +A
Sbjct: 437 VETPLHMA 444



 Score =  105 bits (262), Expect = 3e-23
 Identities = 67/199 (33%), Positives = 101/199 (50%), Gaps = 1/199 (0%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A  G +E +   +  + S A  T +   T LH A   G   + E LL+     N     G
Sbjct: 511 AREGHVETVLALLEKEASQACMTKKGF-TPLHVAAKYGKVRVAELLLERDAHPNAAGKNG 569

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            +PLH+A      +IVK LL +G   ++   NG TPLH AA +N+ E+A  LL+ G + +
Sbjct: 570 LTPLHVAVHHNNLDIVKLLLPRGGSPHSPAWNGYTPLHIAAKQNQVEVARSLLQYGGSAN 629

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           A+     T +H AA +G+ +M+ +LL  +A+ N+ +  G TPLHL   E  V  A +L+ 
Sbjct: 630 AESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIK 689

Query: 194 QGASIYIENKEEKTPLQVA 212
            G  +    +   TPL VA
Sbjct: 690 HGVMVDATTRMGYTPLHVA 708



 Score =  105 bits (261), Expect = 4e-23
 Identities = 61/172 (35%), Positives = 88/172 (51%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A      E+   LLQ G   N +   G +PLH+AA  G  E+V  LL K A  N 
Sbjct: 604 TPLHIAAKQNQVEVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNL 663

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
            N++G TPLH  A +    +A +L++ G   DA      T +H A+  GN+K++  LL +
Sbjct: 664 GNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQH 723

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
           +A  N +   G +PLH A  +   +   LL+  GAS    + +  TPL +AK
Sbjct: 724 QADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIAK 775



 Score =  103 bits (256), Expect = 2e-22
 Identities = 72/240 (30%), Positives = 113/240 (47%), Gaps = 30/240 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG L++  + +     + T  +Q+    LH A   GH ++V  LL   + +      G
Sbjct: 20  ARSGNLDKALDHLRNGVDINT-CNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            + LHIAA AG+DE+V+ L+  GA VNA +Q G TPL+ AA +N  E+   LLE GAN +
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVKFLLENGANQN 138

Query: 134 A-----------------------------KDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
                                         K      A+H AA   + +   +LL    +
Sbjct: 139 VATEDGFTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPN 198

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILKRMV 224
            ++    G TPLH+A   E +  A+LL+++GAS+    +   TPL +A     +I+ R++
Sbjct: 199 PDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLL 258



 Score =  100 bits (249), Expect = 1e-21
 Identities = 66/171 (38%), Positives = 90/171 (52%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           T LH A   GH  IV+ LLQ G   N  +    +PLH+AA AG  E+ K LL   A+VNA
Sbjct: 406 TPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYLLQNKAKVNA 465

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
             ++  TPLH AA      +  +LLE  ANP+       T +H AA +G+++ +  LL  
Sbjct: 466 KAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIAAREGHVETVLALLEK 525

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +AS      +G TPLH+A    +V  A+LL+ + A      K   TPL VA
Sbjct: 526 EASQACMTKKGFTPLHVAAKYGKVRVAELLLERDAHPNAAGKNGLTPLHVA 576



 Score = 99.8 bits (247), Expect = 2e-21
 Identities = 58/174 (33%), Positives = 85/174 (48%)

Query: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
           D  T LH A   GH  + + LL  G   N +   G++PLHIA       +++ LL  GA 
Sbjct: 337 DHLTPLHVAAHCGHHRVAKVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGAS 396

Query: 99  VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHIL 158
           ++AV ++G TPLH A+      I   LL+ GA+P+  +    T +H AA  G+ ++   L
Sbjct: 397 IDAVTESGLTPLHVASFMGHLPIVKNLLQRGASPNVSNVKVETPLHMAARAGHTEVAKYL 456

Query: 159 LYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           L  KA  N +  +  TPLH A         KLL+   A+  +      TPL +A
Sbjct: 457 LQNKAKVNAKAKDDQTPLHCAARIGHTNMVKLLLENNANPNLATTAGHTPLHIA 510



 Score = 95.1 bits (235), Expect = 4e-20
 Identities = 62/177 (35%), Positives = 87/177 (49%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T Q+  T LH A   G+  +V  LL  G  +  K     +PLH AA  G   I + LL  
Sbjct: 235 TPQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDH 294

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA + A  +NG +P+H AA  +  +   +LL+  A  D       T +H AA  G+ ++ 
Sbjct: 295 GAPIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVAAHCGHHRVA 354

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL   A  N +   G TPLH+AC +  V   +LL+  GASI    +   TPL VA
Sbjct: 355 KVLLDKGAKPNSRALNGFTPLHIACKKNHVRVMELLLKTGASIDAVTESGLTPLHVA 411



 Score = 90.5 bits (223), Expect = 1e-18
 Identities = 57/170 (33%), Positives = 85/170 (50%)

Query: 43  ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           ALH A     T     LLQ     +     G++PLHIAA      + + LL +GA VN  
Sbjct: 176 ALHIAARNDDTRTAAVLLQNDPNPDVLSKTGFTPLHIAAHYENLNVAQLLLNRGASVNFT 235

Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
            QNG TPLH A+ +    +  +LL+ GA  + K   E T +H AA  G++++  ILL + 
Sbjct: 236 PQNGITPLHIASRRGNVIMVRLLLDRGAQIETKTKDELTPLHCAARNGHVRISEILLDHG 295

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A    +   G +P+H+A   + ++  +LL+   A I     +  TPL VA
Sbjct: 296 APIQAKTKNGLSPIHMAAQGDHLDCVRLLLQYDAEIDDITLDHLTPLHVA 345



 Score = 82.0 bits (201), Expect = 4e-16
 Identities = 59/231 (25%), Positives = 104/231 (45%), Gaps = 30/231 (12%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A +G+ E ++E +    ++  ++ Q   T L+ A    H E+V+FLL+ G   N   + G
Sbjct: 86  ALAGQDEVVRELVNYGANVNAQS-QKGFTPLYMAAQENHLEVVKFLLENGANQNVATEDG 144

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQ-----------------------------VNAVNQ 104
           ++PL +A   G + +V  L+  G +                              + +++
Sbjct: 145 FTPLAVALQQGHENVVAHLINYGTKGKVRLPALHIAARNDDTRTAAVLLQNDPNPDVLSK 204

Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
            G TPLH AA      +A +LL  GA+ +       T +H A+ +GN+ M+ +LL   A 
Sbjct: 205 TGFTPLHIAAHYENLNVAQLLLNRGASVNFTPQNGITPLHIASRRGNVIMVRLLLDRGAQ 264

Query: 165 TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
              +  +  TPLH A     V  +++L+  GA I  + K   +P+ +A  G
Sbjct: 265 IETKTKDELTPLHCAARNGHVRISEILLDHGAPIQAKTKNGLSPIHMAAQG 315



 Score = 81.6 bits (200), Expect = 5e-16
 Identities = 50/159 (31%), Positives = 78/159 (49%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+  S+L     A        T LH A   GH E+V  LL      N  + +G +PLH+ 
Sbjct: 616 EVARSLLQYGGSANAESVQGVTPLHLAAQEGHAEMVALLLSKQANGNLGNKSGLTPLHLV 675

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           A  G   +   L+  G  V+A  + G TPLH A+     ++   LL+  A+ +AK     
Sbjct: 676 AQEGHVPVADVLIKHGVMVDATTRMGYTPLHVASHYGNIKLVKFLLQHQADVNAKTKLGY 735

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
           + +H+AA +G+  ++ +LL   AS N   ++G TPL +A
Sbjct: 736 SPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGTTPLAIA 774



 Score = 72.4 bits (176), Expect = 3e-13
 Identities = 41/138 (29%), Positives = 71/138 (51%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+   +L+ ++     ++   T LH     GH  + + L++ GV V+     G++PLH+A
Sbjct: 649 EMVALLLSKQANGNLGNKSGLTPLHLVAQEGHVPVADVLIKHGVMVDATTRMGYTPLHVA 708

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA 140
           +  G  ++VK LL   A VNA  + G +PLH AA +   +I  +LL+ GA+P+       
Sbjct: 709 SHYGNIKLVKFLLQHQADVNAKTKLGYSPLHQAAQQGHTDIVTLLLKNGASPNEVSSDGT 768

Query: 141 TAMHRAAAKGNLKMIHIL 158
           T +  A   G + +  +L
Sbjct: 769 TPLAIAKRLGYISVTDVL 786



 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 44/159 (27%), Positives = 79/159 (49%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           + D+ T+   A  +G+ +     L+ GV +N  +  G + LH+A+  G  ++V  LL K 
Sbjct: 9   EADAATSFLRAARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKE 68

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
             +    + G T LH AA   + E+   L+  GAN +A+     T ++ AA + +L+++ 
Sbjct: 69  IILETTTKKGNTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMAAQENHLEVVK 128

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQG 195
            LL   A+ N+   +G TPL +A  +        L++ G
Sbjct: 129 FLLENGANQNVATEDGFTPLAVALQQGHENVVAHLINYG 167



 Score = 43.1 bits (100), Expect = 2e-04
 Identities = 27/100 (27%), Positives = 52/100 (52%)

Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172
           AA     + A+  L  G + +  +      +H A+ +G++KM+  LL+ +        +G
Sbjct: 19  AARSGNLDKALDHLRNGVDINTCNQNGLNGLHLASKEGHVKMVVELLHKEIILETTTKKG 78

Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           NT LH+A    + E  + LV+ GA++  ++++  TPL +A
Sbjct: 79  NTALHIAALAGQDEVVRELVNYGANVNAQSQKGFTPLYMA 118


>gi|68131557 ankyrin repeat domain 28 [Homo sapiens]
          Length = 1053

 Score =  110 bits (276), Expect = 7e-25
 Identities = 71/212 (33%), Positives = 113/212 (53%), Gaps = 2/212 (0%)

Query: 15  YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW 74
           ++G  +E++ +++  K      D + RT LH A   G  EI+E L+  G  VN KD    
Sbjct: 17  FNGDPDEVR-ALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWL 75

Query: 75  SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
           +PLH A ++  +E V+ LL   A VNA ++N  TPLH AA+    + A  L+   +N + 
Sbjct: 76  TPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNV 135

Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194
            D    TA+H AA  G+ +M+ +LL   A+ N  D +    +H A     +E  KLLVS 
Sbjct: 136 SDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSH 195

Query: 195 GASIYIENKEEKTPLQ-VAKGGLGLILKRMVE 225
           GA +  ++K+  TPL   A  G+  ++K +++
Sbjct: 196 GAEVTCKDKKSYTPLHAAASSGMISVVKYLLD 227



 Score =  100 bits (250), Expect = 8e-22
 Identities = 65/201 (32%), Positives = 104/201 (51%), Gaps = 1/201 (0%)

Query: 12  NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
           ++A + K  +  E+++   S    +D+  RTALH A  +GH E+V+ LL  G  +N  D 
Sbjct: 112 HIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDK 171

Query: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
                +H AA  G  E+VK L+  GA+V   ++   TPLH AAS     +   LL+ G +
Sbjct: 172 KDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVD 231

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA-KL 190
            +  + Y  T +H A   G   +++ L+   A  N ++ +G TPLH A          +L
Sbjct: 232 MNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLEL 291

Query: 191 LVSQGASIYIENKEEKTPLQV 211
           LV  GA + +++K+ KTPL +
Sbjct: 292 LVGNGADVNMKSKDGKTPLHM 312



 Score = 99.8 bits (247), Expect = 2e-21
 Identities = 63/193 (32%), Positives = 97/193 (50%)

Query: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
           EE  + +L   +     D++ +T LH A +    +  E L+ L   VN  D AG + LH 
Sbjct: 87  EEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEALVPLLSNVNVSDRAGRTALHH 146

Query: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
           AA +G  E+VK LL +GA +NA ++     +H+AA     E+  +L+  GA    KD   
Sbjct: 147 AAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHIEVVKLLVSHGAEVTCKDKKS 206

Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199
            T +H AA+ G + ++  LL      N  +  GNTPLH+AC   +      L+  GA + 
Sbjct: 207 YTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVACYNGQDVVVNELIDCGAIVN 266

Query: 200 IENKEEKTPLQVA 212
            +N++  TPL  A
Sbjct: 267 QKNEKGFTPLHFA 279



 Score = 97.1 bits (240), Expect = 1e-20
 Identities = 69/223 (30%), Positives = 103/223 (46%), Gaps = 47/223 (21%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D   RT LH A + G+ E +  LL  G   N KD  G SPLH AA+    + + AL+G G
Sbjct: 402 DDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSG 461

Query: 97  AQVNAVNQNGCTPLHYAASKNRH-EIAVMLLEGGANPDAKD-------HYEATAMHR--- 145
           A VN +++ GCTPLHYAA+ +   +    LL   ANP  +D       HY A   HR   
Sbjct: 462 ASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGHRLCL 521

Query: 146 -----------------------------------AAAKGNLKMIHILLYYKASTNIQDT 170
                                              AA  G+ + + +L+      +++++
Sbjct: 522 QLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNS 581

Query: 171 EGNTPLHLACDEERVEEAKLLVSQGASIYIENK-EEKTPLQVA 212
            G TPL LA  +  VE   +L++QGASI +++   ++TP+  A
Sbjct: 582 SGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAA 624



 Score = 91.3 bits (225), Expect = 6e-19
 Identities = 57/175 (32%), Positives = 85/175 (48%)

Query: 38  QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
           +D +T LH     G     + ++Q G  ++ +D  G +PLHIAA  G + ++  L+  GA
Sbjct: 304 KDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGA 363

Query: 98  QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHI 157
                  +G  PLH AA     +    LL  G + D  D +  T +H AAA GNL+ +++
Sbjct: 364 DTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNL 423

Query: 158 LLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           LL   A  N +D  G +PLH A      +    LV  GAS+   ++   TPL  A
Sbjct: 424 LLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYA 478



 Score = 89.4 bits (220), Expect = 2e-18
 Identities = 69/236 (29%), Positives = 107/236 (45%), Gaps = 35/236 (14%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           AY G +E +K  +++  +  T  D+ S T LH A S+G   +V++LL LGV +N+ +  G
Sbjct: 181 AYMGHIEVVK-LLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYG 239

Query: 74  WSPLHIAASAGRDEIVKALL----------------------------------GKGAQV 99
            +PLH+A   G+D +V  L+                                  G GA V
Sbjct: 240 NTPLHVACYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADV 299

Query: 100 NAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL 159
           N  +++G TPLH  A   R   +  +++ GA  D +D    T +H AA  G+  +I+ L+
Sbjct: 300 NMKSKDGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLI 359

Query: 160 YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
              A T  +   G  PLHLA      +  + L+S G  I   +   +T L  A  G
Sbjct: 360 TSGADTAKRGIHGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAG 415



 Score = 89.0 bits (219), Expect = 3e-18
 Identities = 61/189 (32%), Positives = 92/189 (48%), Gaps = 5/189 (2%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA- 72
           AY G  + L+  + +   L  R +   RT L  A   GH E V+ L+  G  +  KD   
Sbjct: 558 AYHGHHQALEVLVQSLLDLDVR-NSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYIL 616

Query: 73  GWSPLHIAASAGRDEIVKALLGKGAQVNAVN---QNGCTPLHYAASKNRHEIAVMLLEGG 129
             +P+H AA+ G  E ++ L+G     NAV+    NG TPL  +      +    LL  G
Sbjct: 617 KRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKG 676

Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAK 189
           AN DAKD +  TA+HR A  G+ + +  LL + A   ++D+ G TP+HL+     +    
Sbjct: 677 ANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLG 736

Query: 190 LLVSQGASI 198
            L+   AS+
Sbjct: 737 ALLQSAASM 745



 Score = 86.7 bits (213), Expect = 2e-17
 Identities = 70/216 (32%), Positives = 103/216 (47%), Gaps = 10/216 (4%)

Query: 17  GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSP 76
           G L  L +S  +  +     D    TALHWAC  GH   VE LL+  V    + +A +SP
Sbjct: 733 GVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEVFQKTEGNA-FSP 791

Query: 77  LHIAA---SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
           LH A    + G  E++   LG  + VNA +  G TPLH AA  +  E   +LL   A  +
Sbjct: 792 LHCAVINDNEGAAEMLIDTLG-ASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVN 850

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLHLACDEERVEEAKLL- 191
           + D    T +  AA  G    + +L+    A   +QD   NT LHLAC +     A L+ 
Sbjct: 851 SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLIL 910

Query: 192 --VSQGASIYIENKEEKTPLQV-AKGGLGLILKRMV 224
             ++    I   N   +TPL V A+ GL ++++ ++
Sbjct: 911 EKITDRNLINATNAALQTPLHVAARNGLTMVVQELL 946



 Score = 79.3 bits (194), Expect = 2e-15
 Identities = 49/160 (30%), Positives = 78/160 (48%)

Query: 24  ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83
           ++I+   ++    D++  T LH A   GH  ++  L+  G     +   G  PLH+AA +
Sbjct: 323 QTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLITSGADTAKRGIHGMFPLHLAALS 382

Query: 84  GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
           G  +  + LL  G  ++  +  G T LH AA+    E   +LL  GA+ + KD +  + +
Sbjct: 383 GFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLECLNLLLNTGADFNKKDKFGRSPL 442

Query: 144 HRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEE 183
           H AAA  N + +  L+   AS N  D  G TPLH A   +
Sbjct: 443 HYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAATSD 482



 Score = 79.3 bits (194), Expect = 2e-15
 Identities = 62/184 (33%), Positives = 92/184 (50%), Gaps = 11/184 (5%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D + +T L  +   GHT+ V  LL  G  V+ KD  G + LH  A  G +E V ALL  G
Sbjct: 650 DGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHG 709

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG----ANPDAKDHYEATAMHRAAAKGNL 152
           A+    +  G TP+H +A+     +   LL+      ANP   D++  TA+H A   G+ 
Sbjct: 710 AKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHE 769

Query: 153 KMIHILLYYKASTNIQDTEGN--TPLHLACDEERVEEAKLLV-SQGASIY-IENKEEKTP 208
             + +LL  +     Q TEGN  +PLH A   +    A++L+ + GASI    + + +TP
Sbjct: 770 TCVELLLEQEV---FQKTEGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTP 826

Query: 209 LQVA 212
           L  A
Sbjct: 827 LHAA 830



 Score = 78.2 bits (191), Expect = 5e-15
 Identities = 62/216 (28%), Positives = 97/216 (44%), Gaps = 41/216 (18%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+  RTALH     GH E V+ LLQ G     +D  G +P+H++A+ G   ++ ALL   
Sbjct: 683 DKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSA 742

Query: 97  AQVNA----VNQNGCTPLHYAASKNRHEIAVMLL-------------------------E 127
           A ++A     + +G T LH+A   N HE  V LL                         E
Sbjct: 743 ASMDANPATADNHGYTALHWACY-NGHETCVELLLEQEVFQKTEGNAFSPLHCAVINDNE 801

Query: 128 GGANP----------DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLH 177
           G A            +A D    T +H AA   +++ + +LL + A  N  D+ G TPL 
Sbjct: 802 GAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLM 861

Query: 178 LACDEERVEEAKLLVSQ-GASIYIENKEEKTPLQVA 212
           +A +  +    ++LVS   A + +++  + T L +A
Sbjct: 862 MAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLA 897



 Score = 70.1 bits (170), Expect = 1e-12
 Identities = 56/194 (28%), Positives = 92/194 (47%), Gaps = 11/194 (5%)

Query: 36  TDQDSRTA---LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKAL 92
           +D D+R     LH A   GH + +E L+Q  + ++ ++ +G +PL +AA  G  E V  L
Sbjct: 543 SDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVL 602

Query: 93  LGKGAQVNAVNQN-GCTPLHYAASKNRHEIAVMLLEGGANP----DAKDHYEATAMHRAA 147
           + +GA +   +     TP+H AA+ N H   + LL G A P    D +D    T +  + 
Sbjct: 603 INQGASILVKDYILKRTPIH-AAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSV 661

Query: 148 AKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKT 207
             G+   ++ LL   A+ + +D  G T LH        E    L+  GA   + +   +T
Sbjct: 662 LNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGRT 721

Query: 208 P--LQVAKGGLGLI 219
           P  L  A G +G++
Sbjct: 722 PIHLSAACGHIGVL 735



 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 50/154 (32%), Positives = 71/154 (46%), Gaps = 5/154 (3%)

Query: 31  SLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVK 90
           S+   TD   RT LH A    H E ++ LL     VN  D  G +PL +AA  G+   V+
Sbjct: 814 SIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAENGQTNTVE 873

Query: 91  ALLGK-GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA---TAMHRA 146
            L+    A++   + +  T LH A SK     A+++LE   + +  +   A   T +H A
Sbjct: 874 MLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAALQTPLHVA 933

Query: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC 180
           A  G   ++  LL   AS    D  G TP  LAC
Sbjct: 934 ARNGLTMVVQELLGKGASVLAVDENGYTPA-LAC 966



 Score = 64.3 bits (155), Expect = 8e-11
 Identities = 53/189 (28%), Positives = 93/189 (49%), Gaps = 16/189 (8%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQ---LGV--------PVNDKDD-AGWSPLHIAASAG 84
           D+    A+H++ + GH   ++ +     L V         ++D D+ A  SPLH+AA  G
Sbjct: 502 DKQGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHG 561

Query: 85  RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH-YEATAM 143
             + ++ L+     ++  N +G TPL  AA K   E   +L+  GA+   KD+  + T +
Sbjct: 562 HHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPI 621

Query: 144 HRAAAKGNLKMIHILLYYKASTN---IQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI 200
           H AA  G+ + + +L+      N   IQD  G TPL L+      +    L+++GA++  
Sbjct: 622 HAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDA 681

Query: 201 ENKEEKTPL 209
           ++K  +T L
Sbjct: 682 KDKWGRTAL 690



 Score = 59.7 bits (143), Expect = 2e-09
 Identities = 40/117 (34%), Positives = 62/117 (52%), Gaps = 4/117 (3%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP---VNDKD 70
           A +G+   ++  + +  +  T  D    TALH ACS GH      +L+       +N  +
Sbjct: 864 AENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATN 923

Query: 71  DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTP-LHYAASKNRHEIAVMLL 126
            A  +PLH+AA  G   +V+ LLGKGA V AV++NG TP L  A +K+  +   ++L
Sbjct: 924 AALQTPLHVAARNGLTMVVQELLGKGASVLAVDENGYTPALACAPNKDVADCLALIL 980



 Score = 38.5 bits (88), Expect = 0.005
 Identities = 22/68 (32%), Positives = 33/68 (48%)

Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
           +A   G+   +  L++ K   N QD E  TPLH A      E  +LL+  GA +  ++ +
Sbjct: 14  QAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSK 73

Query: 205 EKTPLQVA 212
             TPL  A
Sbjct: 74  WLTPLHRA 81


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase 2 [Homo sapiens]
          Length = 1166

 Score =  108 bits (271), Expect = 3e-24
 Identities = 70/218 (32%), Positives = 107/218 (49%), Gaps = 21/218 (9%)

Query: 16  SGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS 75
           +G +E +K  +  +K  +  T     T LH+A   G  ++VE+LLQ G  V  +DD G  
Sbjct: 34  NGDVERVKRLVTPEKVNSRDTAGRKSTPLHFAAGFGRKDVVEYLLQNGANVQARDDGGLI 93

Query: 76  PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAK 135
           PLH A S G  E+V  LL  GA  NA +    TPLH AA K + ++ ++LL+ GA P  +
Sbjct: 94  PLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIR 153

Query: 136 D--------------------HYEATAMHRAAAKGN-LKMIHILLYYKASTNIQDTEGNT 174
           +                     Y+   +  +A  GN  KM+ +L     + +  D   +T
Sbjct: 154 NTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKMMALLTPLNVNCHASDGRKST 213

Query: 175 PLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           PLHLA    RV+  +LL+  GA ++ ++K +  PL  A
Sbjct: 214 PLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHNA 251



 Score = 97.1 bits (240), Expect = 1e-20
 Identities = 72/221 (32%), Positives = 104/221 (47%), Gaps = 23/221 (10%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A +G +E +K+            +    T LH+A       +VE+LLQ G  V+ KD  G
Sbjct: 500 AKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKGG 559

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
             PLH A S G  E+ + L+  GA VN  +    TPLH AA+K ++EI  +LL+ GA+P 
Sbjct: 560 LVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADPT 619

Query: 134 AKDHYEAT--------------------AMHRAAAKGNLKMIHILLYYKASTNIQDTEG- 172
            K+    T                    A+  AA KG L  +   L    + N +DT+G 
Sbjct: 620 KKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVK-KLSSPDNVNCRDTQGR 678

Query: 173 -NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +TPLHLA     +E A+ L+  GA +  ++K    PL  A
Sbjct: 679 HSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNA 719



 Score = 95.5 bits (236), Expect = 3e-20
 Identities = 70/229 (30%), Positives = 101/229 (44%), Gaps = 54/229 (23%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+     LH ACS GH E+ E L++ G  VN  D   ++PLH AA+ G+ EI K LL  G
Sbjct: 556 DKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHG 615

Query: 97  AQVNAVNQN-------------------------------GC------------------ 107
           A     N++                               GC                  
Sbjct: 616 ADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLARVKKLSSPDNVNCRDT 675

Query: 108 -----TPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
                TPLH AA  N  E+A  LL+ GA+ +A+D      +H AA+ G++ +  +L+ Y 
Sbjct: 676 QGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYN 735

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211
           A  N  D    TPLH A  + R +   LL++ GA   ++N+E +TPL +
Sbjct: 736 ACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDL 784



 Score = 94.7 bits (234), Expect = 6e-20
 Identities = 68/207 (32%), Positives = 101/207 (48%), Gaps = 24/207 (11%)

Query: 31  SLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGRDEI 88
           S A    + +   L  AC  G  E V+ L+     VN +D AG   +PLH AA  GR ++
Sbjct: 15  SAAAEAVEPAARELFEACRNGDVERVKRLVT-PEKVNSRDTAGRKSTPLHFAAGFGRKDV 73

Query: 89  VKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
           V+ LL  GA V A +  G  PLH A S    E+  +LL  GA+P+A+D++  T +H AA 
Sbjct: 74  VEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHEAAI 133

Query: 149 KGNLKMIHILLYYKASTNIQDTEGNTPLHLA------------CDEERVEEAK------- 189
           KG + +  +LL + A   I++T+G T L LA              +E +E A+       
Sbjct: 134 KGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNEEKM 193

Query: 190 --LLVSQGASIYIENKEEKTPLQVAKG 214
             LL     + +  +  + TPL +A G
Sbjct: 194 MALLTPLNVNCHASDGRKSTPLHLAAG 220



 Score = 85.5 bits (210), Expect = 3e-17
 Identities = 66/247 (26%), Positives = 104/247 (42%), Gaps = 54/247 (21%)

Query: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
           +++ E +L + +     D      LH ACS GH E+V  LL+ G   N +D+  ++PLH 
Sbjct: 71  KDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLRHGADPNARDNWNYTPLHE 130

Query: 80  AASAGR------------------------------------------DEIVKA------ 91
           AA  G+                                          DE++++      
Sbjct: 131 AAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGEYKKDELLESARSGNE 190

Query: 92  ------LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
                 L       +A +    TPLH AA  NR +I  +LL+ GA+  AKD  +   +H 
Sbjct: 191 EKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGDLVPLHN 250

Query: 146 AAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEE 205
           A + G+ ++  +L+ + A  N  D    TPLH A  + RVE   LL+S GA   + N   
Sbjct: 251 ACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHN 310

Query: 206 KTPLQVA 212
           K+ + +A
Sbjct: 311 KSAIDLA 317



 Score = 83.2 bits (204), Expect = 2e-16
 Identities = 50/136 (36%), Positives = 75/136 (55%), Gaps = 1/136 (0%)

Query: 47  ACSAGHTEIVEFLLQL-GVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQN 105
           A  AG  E V+ L  +  V   D +    +PLH AA   R  +V+ LL  GA V+A ++ 
Sbjct: 499 AAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDKG 558

Query: 106 GCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAST 165
           G  PLH A S   +E+A +L++ GA  +  D ++ T +H AAAKG  ++  +LL + A  
Sbjct: 559 GLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAAAKGKYEICKLLLQHGADP 618

Query: 166 NIQDTEGNTPLHLACD 181
             ++ +GNTPL L  D
Sbjct: 619 TKKNRDGNTPLDLVKD 634



 Score = 81.3 bits (199), Expect = 6e-16
 Identities = 61/222 (27%), Positives = 95/222 (42%), Gaps = 27/222 (12%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI- 79
           ++ E ++  ++     D   +T+LH A   GH +    LL  G   N     G++ L + 
Sbjct: 414 DVVEVVVKHEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG 473

Query: 80  -------------------------AASAGRDEIVKALLG-KGAQVNAVNQNGCTPLHYA 113
                                    AA AG  E VK L   +      +     TPLH+A
Sbjct: 474 NENVQQLLQEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFA 533

Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGN 173
           A  NR  +   LL+ GA+  AKD      +H A + G+ ++  +L+ + A  N+ D    
Sbjct: 534 AGYNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKF 593

Query: 174 TPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
           TPLH A  + + E  KLL+  GA    +N++  TPL + K G
Sbjct: 594 TPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG 635



 Score = 80.5 bits (197), Expect = 1e-15
 Identities = 69/223 (30%), Positives = 100/223 (44%), Gaps = 24/223 (10%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG  E++   +         +D    T LH A      +IV+ LLQ G  V+ KD   
Sbjct: 185 ARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLQHGADVHAKDKGD 244

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
             PLH A S G  E+ + L+  GA VNA++    TPLH AASKNR E+  +LL  GA+P 
Sbjct: 245 LVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPT 304

Query: 134 AKDHYEATAMH---------------------RAAAKGNLKMIHILLYYKASTNIQDTEG 172
             + +  +A+                      +AA + ++  I   L  +          
Sbjct: 305 LLNCHNKSAIDLAPTPQLKERLAYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKHPQTH 364

Query: 173 NTPLHLACDE---ERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            T LH A      +R +  +LL+ +GA+I  + KE  TPL VA
Sbjct: 365 ETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVA 407



 Score = 77.4 bits (189), Expect = 9e-15
 Identities = 44/120 (36%), Positives = 68/120 (56%), Gaps = 2/120 (1%)

Query: 66  VNDKDDAGW--SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAV 123
           VN +D  G   +PLH+AA     E+ + LL  GA VNA ++ G  PLH AAS    ++A 
Sbjct: 670 VNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAA 729

Query: 124 MLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEE 183
           +L++  A  +A D +  T +H AA KG  ++  +LL + A   +++ EG TPL L   ++
Sbjct: 730 LLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADD 789



 Score = 76.6 bits (187), Expect = 2e-14
 Identities = 48/135 (35%), Positives = 66/135 (48%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A  G L  +K+    D      T     T LH A    + E+ E+LLQ G  VN +D  G
Sbjct: 653 AKKGCLARVKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGG 712

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
             PLH AAS G  ++   L+   A VNA ++   TPLH AA K R ++  +LL  GA+P 
Sbjct: 713 LIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPT 772

Query: 134 AKDHYEATAMHRAAA 148
            K+    T +   +A
Sbjct: 773 LKNQEGQTPLDLVSA 787



 Score = 71.6 bits (174), Expect = 5e-13
 Identities = 57/206 (27%), Positives = 94/206 (45%), Gaps = 32/206 (15%)

Query: 38  QDSRTALHWACSAGHT---EIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
           Q   TALH A ++ +    +I E LL+ G  +N+K     +PLH+A+    +++V+ ++ 
Sbjct: 362 QTHETALHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVK 421

Query: 95  KGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH---------- 144
             A+VNA++  G T LH AA     +   +LL  G +P+       TA+           
Sbjct: 422 HEAKVNALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLL 481

Query: 145 ----------------RAAAKGNLKMIHILLYYKASTNIQDTEG--NTPLHLACDEERVE 186
                            AA  G+++ +  L   + S N +D EG  +TPLH A    RV 
Sbjct: 482 QEGISLGNSEADRQLLEAAKAGDVETVKKLCTVQ-SVNCRDIEGRQSTPLHFAAGYNRVS 540

Query: 187 EAKLLVSQGASIYIENKEEKTPLQVA 212
             + L+  GA ++ ++K    PL  A
Sbjct: 541 VVEYLLQHGADVHAKDKGGLVPLHNA 566



 Score = 70.5 bits (171), Expect = 1e-12
 Identities = 57/222 (25%), Positives = 91/222 (40%), Gaps = 27/222 (12%)

Query: 18  KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77
           K +++ E +L   +      ++  T LH A    H ++VE +++    VN  D+ G + L
Sbjct: 378 KRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTSL 437

Query: 78  HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHY-----------AASKNRHEIAVMLL 126
           H AA  G  +  + LL  G   N ++  G T L               S    E    LL
Sbjct: 438 HRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQEGISLGNSEADRQLL 497

Query: 127 EGGANPDAK----------------DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT 170
           E     D +                +  ++T +H AA    + ++  LL + A  + +D 
Sbjct: 498 EAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVSVVEYLLQHGADVHAKDK 557

Query: 171 EGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            G  PLH AC     E A+LLV  GA + + +  + TPL  A
Sbjct: 558 GGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEA 599



 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 45/142 (31%), Positives = 78/142 (54%), Gaps = 9/142 (6%)

Query: 77  LHIAASAG---RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
           LH AA++    R +I + LL KGA +N   +   TPLH A+ K  +++  ++++  A  +
Sbjct: 368 LHCAAASPYPKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVN 427

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           A D+   T++HRAA  G+L+   +LL Y    NI   +G T L +    E V++   L+ 
Sbjct: 428 ALDNLGQTSLHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMG--NENVQQ---LLQ 482

Query: 194 QGASIYIENKEEKTPLQVAKGG 215
           +G S+   ++ ++  L+ AK G
Sbjct: 483 EGISLG-NSEADRQLLEAAKAG 503



 Score = 54.7 bits (130), Expect = 6e-08
 Identities = 33/112 (29%), Positives = 50/112 (44%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+ E +L   +     D+     LH A S GH ++   L++    VN  D   ++PLH A
Sbjct: 693 EVAEYLLQHGADVNAQDKGGLIPLHNAASYGHVDVAALLIKYNACVNATDKWAFTPLHEA 752

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
           A  GR ++   LL  GA     NQ G TPL   ++ +   +    +   A P
Sbjct: 753 AQKGRTQLCALLLAHGADPTLKNQEGQTPLDLVSADDVSALLTAAMPPSALP 804



 Score = 51.6 bits (122), Expect = 5e-07
 Identities = 56/226 (24%), Positives = 91/226 (40%), Gaps = 26/226 (11%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVP-----VNDKDDAGWS 75
           E+ E ++   +     D    T LH A S    E+   LL  G        ++K     +
Sbjct: 258 EVTELLVKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSYGADPTLLNCHNKSAIDLA 317

Query: 76  PL-------------HIAASAGRDEIVKALLGKGAQVNAVN----QNGCTPLHYAASK-- 116
           P              H    A R+  V  +  K   +  VN    Q   T LH AA+   
Sbjct: 318 PTPQLKERLAYEFKGHSLLQAAREADVTRIK-KHLSLEMVNFKHPQTHETALHCAAASPY 376

Query: 117 -NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTP 175
             R +I  +LL  GAN + K     T +H A+ K +  ++ +++ ++A  N  D  G T 
Sbjct: 377 PKRKQICELLLRKGANINEKTKEFLTPLHVASEKAHNDVVEVVVKHEAKVNALDNLGQTS 436

Query: 176 LHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLILK 221
           LH A     ++  +LL+S G    I + +  T LQ+    +  +L+
Sbjct: 437 LHRAAYCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQLLQ 482


>gi|62988328 ankyrin repeat domain 50 [Homo sapiens]
          Length = 1429

 Score =  106 bits (265), Expect = 1e-23
 Identities = 55/176 (31%), Positives = 98/176 (55%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D + RT L  A + G+ E+V  LL  G+  N +DDAGW+PLH+AA  G   I +AL+ +G
Sbjct: 811 DSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQG 870

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
           A+ N ++ +G  P   A+ +  ++   +LLE  +N D + +    A+  AA +G+  ++ 
Sbjct: 871 ARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVE 930

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +L  + A  N +D +G   L++   E ++  A+  +  GA++   + E +T L V+
Sbjct: 931 LLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVS 986



 Score =  106 bits (264), Expect = 2e-23
 Identities = 71/215 (33%), Positives = 116/215 (53%), Gaps = 6/215 (2%)

Query: 17  GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSP 76
           G  E++  ++L   +   + D + RTAL  A   GH EIVE LL  G  VN +D  G + 
Sbjct: 654 GGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTA 713

Query: 77  LHIA-----ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
           L +A     AS G   +V  L+ +GA+V+  +++G TPL  AA +   ++  +LLEGGA+
Sbjct: 714 LSVAALCVPASKGHASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGAD 773

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
            D  D+   T +  AA+ G+  +++ LL++ A+ +  D+EG T L +A  +  VE  + L
Sbjct: 774 VDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTL 833

Query: 192 VSQGASIYIENKEEKTPLQVAK-GGLGLILKRMVE 225
           + +G      +    TPL +A   G  LI + ++E
Sbjct: 834 LDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIE 868



 Score = 94.4 bits (233), Expect = 7e-20
 Identities = 69/204 (33%), Positives = 98/204 (48%), Gaps = 6/204 (2%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWAC-----SAGHTEIVEFLLQLGVPVND 68
           AY G   E+ E +L   +     D D RTAL  A      S GH  +V  L+  G  V+ 
Sbjct: 685 AYMGH-REIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKGHASVVSLLIDRGAEVDH 743

Query: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128
            D  G +PL +AA  G  ++V  LL  GA V+  + NG TPL  AAS     +   LL  
Sbjct: 744 CDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFW 803

Query: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA 188
           GA  D+ D    T +  A+A+GN++++  LL      N +D  G TPLH+A  E      
Sbjct: 804 GAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLIC 863

Query: 189 KLLVSQGASIYIENKEEKTPLQVA 212
           + L+ QGA     + + + P  +A
Sbjct: 864 EALIEQGARTNEIDNDGRIPFILA 887



 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 67/182 (36%), Positives = 92/182 (50%), Gaps = 5/182 (2%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           TDQD  TAL  A   GHTE+V  LL  GV V+  D    + L  AA  G ++IV  LL  
Sbjct: 607 TDQDGWTALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQH 666

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA-----AAKG 150
           GA+VN  +  G T L  AA     EI   LL+ GA  + +D    TA+  A     A+KG
Sbjct: 667 GAEVNKADNEGRTALIAAAYMGHREIVEHLLDHGAEVNHEDVDGRTALSVAALCVPASKG 726

Query: 151 NLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQ 210
           +  ++ +L+   A  +  D +G TPL +A  E  V+   LL+  GA +   +   +TPL 
Sbjct: 727 HASVVSLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLL 786

Query: 211 VA 212
            A
Sbjct: 787 AA 788



 Score = 89.7 bits (221), Expect = 2e-18
 Identities = 61/202 (30%), Positives = 97/202 (48%)

Query: 11  CNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD 70
           C +  + + E+   ++L + +   + D + RT L  A  +G  ++V  L+  G  +  +D
Sbjct: 516 CIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVVNLLVSRGADLEIED 575

Query: 71  DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130
             G +PL +AA  G  ++V  L+G GA +N  +Q+G T L  AA     E+   LL  G 
Sbjct: 576 AHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWGGHTEVVSALLYAGV 635

Query: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKL 190
             D  D    TA+  AA  G+  ++  LL + A  N  D EG T L  A      E  + 
Sbjct: 636 KVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTALIAAAYMGHREIVEH 695

Query: 191 LVSQGASIYIENKEEKTPLQVA 212
           L+  GA +  E+ + +T L VA
Sbjct: 696 LLDHGAEVNHEDVDGRTALSVA 717



 Score = 89.7 bits (221), Expect = 2e-18
 Identities = 55/189 (29%), Positives = 93/189 (49%)

Query: 24   ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83
            E+++   +     D D R     A   GH + V+ LL+    ++ +   G + L +AA  
Sbjct: 864  EALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALE 923

Query: 84   GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
            G  +IV+ L   GA VN  + +G   L+  A +N+  +A   LE GAN +A D    TA+
Sbjct: 924  GHRDIVELLFSHGADVNCKDADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTAL 983

Query: 144  HRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENK 203
            H +  +G+++M+ +L+ Y A  N  D E  + L  A  +  V+  +LL+  GA +     
Sbjct: 984  HVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCN 1043

Query: 204  EEKTPLQVA 212
            +  T L +A
Sbjct: 1044 QGATALCIA 1052



 Score = 87.8 bits (216), Expect = 7e-18
 Identities = 58/189 (30%), Positives = 96/189 (50%), Gaps = 1/189 (0%)

Query: 25  SILADKSLAT-RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83
           S+L D+       D+D  T L  A   GH ++V+ LL+ G  V+  D+ G +PL  AAS 
Sbjct: 732 SLLIDRGAEVDHCDKDGMTPLLVAAYEGHVDVVDLLLEGGADVDHTDNNGRTPLLAAASM 791

Query: 84  GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
           G   +V  LL  GA V++++  G T L  A+++   E+   LL+ G + + +D    T +
Sbjct: 792 GHASVVNTLLFWGAAVDSIDSEGRTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPL 851

Query: 144 HRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENK 203
           H AA +G+  +   L+   A TN  D +G  P  LA  E   +  ++L+   ++I     
Sbjct: 852 HMAAFEGHRLICEALIEQGARTNEIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGY 911

Query: 204 EEKTPLQVA 212
           + +  L+VA
Sbjct: 912 DGRNALRVA 920



 Score = 85.9 bits (211), Expect = 3e-17
 Identities = 59/197 (29%), Positives = 101/197 (51%), Gaps = 1/197 (0%)

Query: 26   ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
            +L +KS   +   D R AL  A   GH +IVE L   G  VN KD  G   L+I A   +
Sbjct: 899  LLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFSHGADVNCKDADGRPTLYILALENQ 958

Query: 86   DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
              + +  L  GA V A +  G T LH +  +   E+  +L+   A+ +A D+ + +A+  
Sbjct: 959  LTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQS 1018

Query: 146  AAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEE 205
            AA +G++K++ +L+ + A  +    +G T L +A  E  ++  ++L+  GA     ++  
Sbjct: 1019 AAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFG 1078

Query: 206  KTPLQV-AKGGLGLILK 221
            +T ++V AK G   I+K
Sbjct: 1079 RTAMRVAAKNGHSQIIK 1095



 Score = 85.5 bits (210), Expect = 3e-17
 Identities = 59/198 (29%), Positives = 97/198 (48%), Gaps = 1/198 (0%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           AY G ++ + + +L   +    TD + RT L  A S GH  +V  LL  G  V+  D  G
Sbjct: 756 AYEGHVDVV-DLLLEGGADVDHTDNNGRTPLLAAASMGHASVVNTLLFWGAAVDSIDSEG 814

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            + L IA++ G  E+V+ LL +G   N  +  G TPLH AA +    I   L+E GA  +
Sbjct: 815 RTVLSIASAQGNVEVVRTLLDRGLDENHRDDAGWTPLHMAAFEGHRLICEALIEQGARTN 874

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
             D+        A+ +G+   + ILL  K++ + +  +G   L +A  E   +  +LL S
Sbjct: 875 EIDNDGRIPFILASQEGHYDCVQILLENKSNIDQRGYDGRNALRVAALEGHRDIVELLFS 934

Query: 194 QGASIYIENKEEKTPLQV 211
            GA +  ++ + +  L +
Sbjct: 935 HGADVNCKDADGRPTLYI 952



 Score = 81.3 bits (199), Expect = 6e-16
 Identities = 50/144 (34%), Positives = 77/144 (53%)

Query: 22   LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
            + E  L + +    +D + RTALH +C  GH E+V+ L+     VN  D+   S L  AA
Sbjct: 961  MAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYHADVNAADNEKRSALQSAA 1020

Query: 82   SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEAT 141
              G  ++V+ L+  GA V+     G T L  AA +   ++  +LLE GA+P+  D +  T
Sbjct: 1021 WQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQVLLEHGADPNHADQFGRT 1080

Query: 142  AMHRAAAKGNLKMIHILLYYKAST 165
            AM  AA  G+ ++I +L  Y AS+
Sbjct: 1081 AMRVAAKNGHSQIIKLLEKYGASS 1104



 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 48/161 (29%), Positives = 77/161 (47%)

Query: 37   DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
            D D R  L+         + E+ L+ G  V   D  G + LH++   G  E+V+ L+   
Sbjct: 943  DADGRPTLYILALENQLTMAEYFLENGANVEASDAEGRTALHVSCWQGHMEMVQVLIAYH 1002

Query: 97   AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
            A VNA +    + L  AA +   ++  +L+E GA  D   +  ATA+  AA +G++ ++ 
Sbjct: 1003 ADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIAAQEGHIDVVQ 1062

Query: 157  ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197
            +LL + A  N  D  G T + +A      +  KLL   GAS
Sbjct: 1063 VLLEHGADPNHADQFGRTAMRVAAKNGHSQIIKLLEKYGAS 1103



 Score = 67.4 bits (163), Expect = 9e-12
 Identities = 44/162 (27%), Positives = 81/162 (50%), Gaps = 2/162 (1%)

Query: 54  EIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
           E+++ L++ G  VN +DD   +   +  +  R++ ++ LL  GA VN  + NG T L  A
Sbjct: 495 EVLQLLVKAGAHVNSEDDR--TSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANA 552

Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGN 173
           A     ++  +L+  GA+ + +D +  T +  AA +G+ K+++ L+   A+ N  D +G 
Sbjct: 553 AYSGSLDVVNLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGW 612

Query: 174 TPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
           T L  A      E    L+  G  +   + + +T L+ A  G
Sbjct: 613 TALRSAAWGGHTEVVSALLYAGVKVDCADADSRTALRAAAWG 654



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 50/183 (27%), Positives = 82/183 (44%)

Query: 30  KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
           K+ A    +D RT+     +    + +  LL  G  VN  D  G + L  AA +G  ++V
Sbjct: 502 KAGAHVNSEDDRTSCIVRQALEREDSIRTLLDNGASVNQCDSNGRTLLANAAYSGSLDVV 561

Query: 90  KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAK 149
             L+ +GA +   + +G TPL  AA +   ++   L+  GAN +  D    TA+  AA  
Sbjct: 562 NLLVSRGADLEIEDAHGHTPLTLAARQGHTKVVNCLIGCGANINHTDQDGWTALRSAAWG 621

Query: 150 GNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPL 209
           G+ +++  LLY     +  D +  T L  A      +    L+  GA +   + E +T L
Sbjct: 622 GHTEVVSALLYAGVKVDCADADSRTALRAAAWGGHEDIVLNLLQHGAEVNKADNEGRTAL 681

Query: 210 QVA 212
             A
Sbjct: 682 IAA 684



 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 36/107 (33%), Positives = 57/107 (53%), Gaps = 1/107 (0%)

Query: 21   ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
            E+ + ++A  +     D + R+AL  A   GH ++V+ L++ G  V+   + G + L IA
Sbjct: 993  EMVQVLIAYHADVNAADNEKRSALQSAAWQGHVKVVQLLIEHGAVVDHTCNQGATALCIA 1052

Query: 81   ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127
            A  G  ++V+ LL  GA  N  +Q G T +  AA KN H   + LLE
Sbjct: 1053 AQEGHIDVVQVLLEHGADPNHADQFGRTAMRVAA-KNGHSQIIKLLE 1098


>gi|24233530 ankyrin repeat domain 44 [Homo sapiens]
          Length = 919

 Score =  105 bits (263), Expect = 2e-23
 Identities = 69/201 (34%), Positives = 102/201 (50%), Gaps = 1/201 (0%)

Query: 12  NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
           ++A + K  +  E I+   S    +D+  RTALH A   GH E+V  LL  G  +N  D 
Sbjct: 87  HVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVNLLLAKGANINAFDK 146

Query: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
                LH AA  G  ++V  L+  GA+V   ++ G TPLH AAS  +  +   LL  G  
Sbjct: 147 KDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAAASNGQINVVKHLLNLGVE 206

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA-KL 190
            D  + Y  TA+H A   G   +++ L+ Y A+ N  +  G TPLH A          +L
Sbjct: 207 IDEINVYGNTALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLEL 266

Query: 191 LVSQGASIYIENKEEKTPLQV 211
           LV+ GA + I++K+ K+PL +
Sbjct: 267 LVNNGADVNIQSKDGKSPLHM 287



 Score =  104 bits (259), Expect = 7e-23
 Identities = 60/176 (34%), Positives = 97/176 (55%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D + RT LH A   G  EI+E L+  G  VN KD+   +PLH A ++  +E V+ L+   
Sbjct: 13  DSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVLIKHS 72

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
           A VNA ++N  TPLH AA+    + A +++   ++ +  D    TA+H AA  G+++M++
Sbjct: 73  ADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHVEMVN 132

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +LL   A+ N  D +    LH A     ++   LL++ GA +  ++K+  TPL  A
Sbjct: 133 LLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVTCKDKKGYTPLHAA 188



 Score = 92.4 bits (228), Expect = 3e-19
 Identities = 59/199 (29%), Positives = 94/199 (47%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A + + EE  + ++   +     D++ +T LH A +    +  E ++ L   VN  D  G
Sbjct: 56  AVASRSEEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGG 115

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            + LH AA  G  E+V  LL KGA +NA ++     LH+AA     ++  +L+  GA   
Sbjct: 116 RTALHHAALNGHVEMVNLLLAKGANINAFDKKDRRALHWAAYMGHLDVVALLINHGAEVT 175

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
            KD    T +H AA+ G + ++  LL      +  +  GNT LH+AC   +      L+ 
Sbjct: 176 CKDKKGYTPLHAAASNGQINVVKHLLNLGVEIDEINVYGNTALHIACYNGQDAVVNELID 235

Query: 194 QGASIYIENKEEKTPLQVA 212
            GA++   N    TPL  A
Sbjct: 236 YGANVNQPNNNGFTPLHFA 254



 Score = 86.3 bits (212), Expect = 2e-17
 Identities = 51/147 (34%), Positives = 80/147 (54%)

Query: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
           VN  D    +PLH+AA  G  EI++ L+  GA+VNA +    TPLH A +    E   +L
Sbjct: 9   VNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRSEEAVQVL 68

Query: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185
           ++  A+ +A+D    T +H AAA   +K   +++   +S N+ D  G T LH A     V
Sbjct: 69  IKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHHAALNGHV 128

Query: 186 EEAKLLVSQGASIYIENKEEKTPLQVA 212
           E   LL+++GA+I   +K+++  L  A
Sbjct: 129 EMVNLLLAKGANINAFDKKDRRALHWA 155



 Score = 81.6 bits (200), Expect = 5e-16
 Identities = 58/173 (33%), Positives = 82/173 (47%), Gaps = 6/173 (3%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG---VPVNDKD 70
           A+ G  E ++  I    S+  + +   RT LH +   GHT  +  LL++      V+ KD
Sbjct: 583 AFKGHTECVEALINPGASIFVKDNVTKRTPLHASVINGHTLCLRLLLEIADNPEAVDVKD 642

Query: 71  DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130
             G +PL +A + G  + V  LL K A V+ V+  GCT LH        E   MLLE   
Sbjct: 643 AKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEV 702

Query: 131 NPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTN---IQDTEGNTPLHLAC 180
           +   KD    T +H AAA+G+   +  LL    S      +D +G TPLH AC
Sbjct: 703 SILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWAC 755



 Score = 81.3 bits (199), Expect = 6e-16
 Identities = 56/175 (32%), Positives = 84/175 (48%), Gaps = 1/175 (0%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEI-VKALLGKGAQVN 100
           TALH AC  G   +V  L+  G  VN  ++ G++PLH AA++    + ++ L+  GA VN
Sbjct: 216 TALHIACYNGQDAVVNELIDYGANVNQPNNNGFTPLHFAAASTHGALCLELLVNNGADVN 275

Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY 160
             +++G +PLH  A   R   +  L++ G   D  D    T +H AA  G+  +I+ L  
Sbjct: 276 IQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRT 335

Query: 161 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGG 215
             A T         PLHLA      +  + L+S G  I   +K  +T L  A  G
Sbjct: 336 SGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAG 390



 Score = 78.6 bits (192), Expect = 4e-15
 Identities = 68/254 (26%), Positives = 106/254 (41%), Gaps = 65/254 (25%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+  RT LH A + G+ E ++ L   G   + KD  G +PLH AA+      ++ L+  G
Sbjct: 377 DKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTG 436

Query: 97  AQVNAVNQNGCTPLHYAASK----------NRHE------------------IAVMLLEG 128
           A VN  +  G T LHYAA+           N H+                      LL+ 
Sbjct: 437 ANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCLEFLLQN 496

Query: 129 GANPDAKD-------HYEA----------------------------TAMHRAAAKGNLK 153
            ANP  +D       HY A                            + +H AA  G+ +
Sbjct: 497 DANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAAYNGHHQ 556

Query: 154 MIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI-ENKEEKTPLQVA 212
            + +LL      +I+D +G T L LA  +   E  + L++ GASI++ +N  ++TPL  +
Sbjct: 557 ALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKRTPLHAS 616

Query: 213 K-GGLGLILKRMVE 225
              G  L L+ ++E
Sbjct: 617 VINGHTLCLRLLLE 630



 Score = 77.4 bits (189), Expect = 9e-15
 Identities = 52/175 (29%), Positives = 79/175 (45%)

Query: 38  QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
           +D ++ LH     G     + L+Q G  ++  D  G +PLH+AA  G + ++  L   GA
Sbjct: 279 KDGKSPLHMTAVHGRFTRSQTLIQNGGEIDCVDKDGNTPLHVAARYGHELLINTLRTSGA 338

Query: 98  QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHI 157
                  +   PLH AA     +    LL  G   D  D +  T +H AAA GN++ I +
Sbjct: 339 DTAKCGIHSMFPLHLAALNAHSDCCRKLLSSGFEIDTPDKFGRTCLHAAAAGGNVECIKL 398

Query: 158 LLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           L    A  + +D  G TPLH A         + LV+ GA++   +   +T L  A
Sbjct: 399 LQSSGADFHKKDKCGRTPLHYAAANCHFHCIETLVTTGANVNETDDWGRTALHYA 453



 Score = 77.4 bits (189), Expect = 9e-15
 Identities = 59/178 (33%), Positives = 93/178 (52%), Gaps = 6/178 (3%)

Query: 40  SRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV 99
           +++ LH A   GH + +E LLQ  V ++ +D+ G + L +AA  G  E V+AL+  GA +
Sbjct: 542 TKSPLHLAAYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASI 601

Query: 100 NAV-NQNGCTPLHYAASKNRHEIAV-MLLEGGANPDAKDHYEA---TAMHRAAAKGNLKM 154
               N    TPLH A+  N H + + +LLE   NP+A D  +A   T +  A A G++  
Sbjct: 602 FVKDNVTKRTPLH-ASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDA 660

Query: 155 IHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + +LL  +A+ +  D  G T LH        E  ++L+ Q  SI  ++   +TPL  A
Sbjct: 661 VSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718



 Score = 76.3 bits (186), Expect = 2e-14
 Identities = 55/172 (31%), Positives = 81/172 (47%), Gaps = 1/172 (0%)

Query: 42  TALHWACSAGHTEI-VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100
           T LH+A ++ H  + +E L+  G  VN +   G SPLH+ A  GR    + L+  G +++
Sbjct: 249 TPLHFAAASTHGALCLELLVNNGADVNIQSKDGKSPLHMTAVHGRFTRSQTLIQNGGEID 308

Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY 160
            V+++G TPLH AA      +   L   GA+      +    +H AA   +      LL 
Sbjct: 309 CVDKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLS 368

Query: 161 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
                +  D  G T LH A     VE  KLL S GA  + ++K  +TPL  A
Sbjct: 369 SGFEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYA 420



 Score = 75.1 bits (183), Expect = 5e-14
 Identities = 57/170 (33%), Positives = 82/170 (48%), Gaps = 5/170 (2%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD-A 72
           AY+G  + L+  + +   L  R D+  RTAL  A   GHTE VE L+  G  +  KD+  
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIR-DEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVT 608

Query: 73  GWSPLHIAASAGRDEIVKALLGKGAQVNAV---NQNGCTPLHYAASKNRHEIAVMLLEGG 129
             +PLH +   G    ++ LL       AV   +  G TPL  A +    +   +LLE  
Sbjct: 609 KRTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKE 668

Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
           AN D  D    TA+HR    G+ + + +LL  + S   +D+ G TPLH A
Sbjct: 669 ANVDTVDILGCTALHRGIMTGHEECVQMLLEQEVSILCKDSRGRTPLHYA 718



 Score = 70.5 bits (171), Expect = 1e-12
 Identities = 48/181 (26%), Positives = 92/181 (50%), Gaps = 6/181 (3%)

Query: 24  ESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG--WSPLHIAA 81
           E +L + +  +  D++   ++H+A + GH + +E LL+      ++ D+G   SPLH+AA
Sbjct: 491 EFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLAA 550

Query: 82  SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHY-EA 140
             G  + ++ LL     ++  ++ G T L  AA K   E    L+  GA+   KD+  + 
Sbjct: 551 YNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTKR 610

Query: 141 TAMHRAAAKGNLKMIHILLYY---KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197
           T +H +   G+   + +LL       + +++D +G TPL LA     ++   LL+ + A+
Sbjct: 611 TPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLAVAYGHIDAVSLLLEKEAN 670

Query: 198 I 198
           +
Sbjct: 671 V 671



 Score = 68.9 bits (167), Expect = 3e-12
 Identities = 56/186 (30%), Positives = 86/186 (46%), Gaps = 19/186 (10%)

Query: 19  LEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQ-------LGVPVNDKDD 71
           L EL +  L+++    + D    T LHWAC  G+   +E LL+       +G P      
Sbjct: 727 LSELLQMALSEEDCCFK-DNQGYTPLHWACYNGNENCIEVLLEQKCFRKFIGNP------ 779

Query: 72  AGWSPLHIAASAGRDEIVKALLGK--GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGG 129
             ++PLH A           LLG    + V+  +  G TPL  AA  +  E   +LL   
Sbjct: 780 --FTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHS 837

Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILL-YYKASTNIQDTEGNTPLHLACDEERVEEA 188
           A  +A D+   TA+  AA  G    + IL+   +A   ++D + NTPLHLAC +   + A
Sbjct: 838 APVNAVDNSGKTALMMAAENGQAGAVDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCA 897

Query: 189 KLLVSQ 194
            L++ +
Sbjct: 898 LLILDK 903



 Score = 68.6 bits (166), Expect = 4e-12
 Identities = 38/121 (31%), Positives = 66/121 (54%)

Query: 92  LLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGN 151
           L+ K   VN ++    TPLH AA     EI  +L+  GA  +AKD+   T +HRA A  +
Sbjct: 2   LIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASRS 61

Query: 152 LKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211
            + + +L+ + A  N +D    TPLH+A   + V+ A++++   +S+ + ++  +T L  
Sbjct: 62  EEAVQVLIKHSADVNARDKNWQTPLHVAAANKAVKCAEVIIPLLSSVNVSDRGGRTALHH 121

Query: 212 A 212
           A
Sbjct: 122 A 122



 Score = 66.6 bits (161), Expect = 2e-11
 Identities = 51/181 (28%), Positives = 76/181 (41%), Gaps = 16/181 (8%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+D  T LH A   GH  ++  L   G            PLH+AA     +  + LL  G
Sbjct: 311 DKDGNTPLHVAARYGHELLINTLRTSGADTAKCGIHSMFPLHLAALNAHSDCCRKLLSSG 370

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
            +++  ++ G T LH AA+    E   +L   GA+   KD    T +H AAA  +   I 
Sbjct: 371 FEIDTPDKFGRTCLHAAAAGGNVECIKLLQSSGADFHKKDKCGRTPLHYAAANCHFHCIE 430

Query: 157 ILLYYKASTNIQDTEGNTPLHLAC----------------DEERVEEAKLLVSQGASIYI 200
            L+   A+ N  D  G T LH A                 + E +E A+ L  + A++ +
Sbjct: 431 TLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLCL 490

Query: 201 E 201
           E
Sbjct: 491 E 491



 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 55/213 (25%), Positives = 84/213 (39%), Gaps = 37/213 (17%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D   +T L  A + GH + V  LL+    V+  D  G + LH     G +E V+ LL + 
Sbjct: 642 DAKGQTPLMLAVAYGHIDAVSLLLEKEANVDTVDILGCTALHRGIMTGHEECVQMLLEQE 701

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA---KDHYEATAMHRAAAKGNLK 153
             +   +  G TPLHYAA++        LL+   + +    KD+   T +H A   GN  
Sbjct: 702 VSILCKDSRGRTPLHYAAARGHATWLSELLQMALSEEDCCFKDNQGYTPLHWACYNGNEN 761

Query: 154 MIHILLYYK----------------------------------ASTNIQDTEGNTPLHLA 179
            I +LL  K                                  +  + +D +G TPL  A
Sbjct: 762 CIEVLLEQKCFRKFIGNPFTPLHCAIINDHGNCASLLLGAIDSSIVSCRDDKGRTPLRAA 821

Query: 180 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
              + VE  +LL+   A +   +   KT L +A
Sbjct: 822 AFADHVECLQLLLRHSAPVNAVDNSGKTALMMA 854



 Score = 61.6 bits (148), Expect = 5e-10
 Identities = 55/223 (24%), Positives = 98/223 (43%), Gaps = 34/223 (15%)

Query: 24  ESILADKSLATRTDQDSRTALHWACSAG----------------------------HTEI 55
           E+++   +    TD   RTALH+A ++                              T  
Sbjct: 430 ETLVTTGANVNETDDWGRTALHYAAASDMDRNKTILGNAHDNSEELERARELKEKEATLC 489

Query: 56  VEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCT--PLHYA 113
           +EFLLQ     + +D  G++ +H AA+ G  + ++ LL +       + +G T  PLH A
Sbjct: 490 LEFLLQNDANPSIRDKEGYNSIHYAAAYGHRQCLELLLERTNSGFEESDSGATKSPLHLA 549

Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQD-TEG 172
           A    H+   +LL+   + D +D    TA+  AA KG+ + +  L+   AS  ++D    
Sbjct: 550 AYNGHHQALEVLLQSLVDLDIRDEKGRTALDLAAFKGHTECVEALINPGASIFVKDNVTK 609

Query: 173 NTPLHLACDEERVEEAKLLV---SQGASIYIENKEEKTPLQVA 212
            TPLH +         +LL+       ++ +++ + +TPL +A
Sbjct: 610 RTPLHASVINGHTLCLRLLLEIADNPEAVDVKDAKGQTPLMLA 652



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 27/89 (30%), Positives = 44/89 (49%)

Query: 124 MLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEE 183
           ML+    + +  D  + T +H AA  G+ ++I +L+   A  N +D    TPLH A    
Sbjct: 1   MLIHKTEDVNTLDSEKRTPLHVAAFLGDAEIIELLILSGARVNAKDNMWLTPLHRAVASR 60

Query: 184 RVEEAKLLVSQGASIYIENKEEKTPLQVA 212
             E  ++L+   A +   +K  +TPL VA
Sbjct: 61  SEEAVQVLIKHSADVNARDKNWQTPLHVA 89



 Score = 34.3 bits (77), Expect = 0.089
 Identities = 26/110 (23%), Positives = 41/110 (37%), Gaps = 34/110 (30%)

Query: 29  DKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWS------------- 75
           D S+ +  D   RT L  A  A H E ++ LL+   PVN  D++G +             
Sbjct: 803 DSSIVSCRDDKGRTPLRAAAFADHVECLQLLLRHSAPVNAVDNSGKTALMMAAENGQAGA 862

Query: 76  ---------------------PLHIAASAGRDEIVKALLGKGAQVNAVNQ 104
                                PLH+A S G ++    +L K    + +N+
Sbjct: 863 VDILVNSAQADLTVKDKDLNTPLHLACSKGHEKCALLILDKIQDESLINE 912


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
           polymerase [Homo sapiens]
          Length = 1327

 Score =  105 bits (261), Expect = 4e-23
 Identities = 75/232 (32%), Positives = 111/232 (47%), Gaps = 33/232 (14%)

Query: 14  AYSGKLEELKESI----------LADKSLATRTDQDSRTA--LHWACSAGHTEIVEFLLQ 61
           A SG L EL E+           L D +     D   R +  LH+A   G  ++VE LLQ
Sbjct: 178 AVSGALRELLEACRNGDVSRVKRLVDAANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQ 237

Query: 62  LGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEI 121
           +G  V+ +DD G  PLH A S G  E+V  LL +GA  NA +    TPLH AA K + ++
Sbjct: 238 MGANVHARDDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDV 297

Query: 122 AVMLLEGGANPDAKD--------------------HYEATAMHRAAAKGN-LKMIHILLY 160
            ++LL+ GA+P+ ++                     Y+   +  AA  GN  K++ +L  
Sbjct: 298 CIVLLQHGADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTP 357

Query: 161 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
              + +  D   +TPLHLA    RV   +LL+  GA ++ ++K    PL  A
Sbjct: 358 LNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNA 409



 Score = 96.7 bits (239), Expect = 1e-20
 Identities = 71/230 (30%), Positives = 101/230 (43%), Gaps = 54/230 (23%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+     LH ACS GH E+ E L++ G  VN  D   ++PLH AA+ G+ EI K LL  G
Sbjct: 714 DKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEICKLLLKHG 773

Query: 97  AQVNAVNQN-------------------------------GC------------------ 107
           A     N++                               GC                  
Sbjct: 774 ADPTKKNRDGNTPLDLVKEGDTDIQDLLRGDAALLDAAKKGCLARVQKLCTPENINCRDT 833

Query: 108 -----TPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
                TPLH AA  N  E+A  LLE GA+ +A+D      +H AA+ G++ +  +L+ Y 
Sbjct: 834 QGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYN 893

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
              N  D    TPLH A  + R +   LL++ GA   ++N+E +TPL +A
Sbjct: 894 TCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLA 943



 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 66/191 (34%), Positives = 97/191 (50%), Gaps = 24/191 (12%)

Query: 47  ACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGRDEIVKALLGKGAQVNAVNQ 104
           AC  G    V+ L+     VN KD AG   SPLH AA  GR ++V+ LL  GA V+A + 
Sbjct: 189 ACRNGDVSRVKRLVD-AANVNAKDMAGRKSSPLHFAAGFGRKDVVEHLLQMGANVHARDD 247

Query: 105 NGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKAS 164
            G  PLH A S    E+  +LL  GA+P+A+D++  T +H AA KG + +  +LL + A 
Sbjct: 248 GGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHGAD 307

Query: 165 TNIQDTEGNTPLHLA------------CDEERVEEAK---------LLVSQGASIYIENK 203
            NI++T+G + L LA              +E +E A+         LL     + +  + 
Sbjct: 308 PNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDG 367

Query: 204 EEKTPLQVAKG 214
            + TPL +A G
Sbjct: 368 RKSTPLHLAAG 378



 Score = 89.7 bits (221), Expect = 2e-18
 Identities = 71/223 (31%), Positives = 102/223 (45%), Gaps = 24/223 (10%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG  E+L   +         +D    T LH A       IV+ LLQ G  V+ KD  G
Sbjct: 343 ARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGG 402

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
             PLH A S G  E+ + LL  GA VNA++    TPLH AASKNR E+  +LL  GA+P 
Sbjct: 403 LVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPT 462

Query: 134 AKD---------------------HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172
             +                      ++  ++ +AA + +L  +   L  +     Q    
Sbjct: 463 LVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQPQSH 522

Query: 173 NTPLHLA---CDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            T LH A      +R +  +LL+ +GA++  +NK+  TPL VA
Sbjct: 523 ETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVA 565



 Score = 85.1 bits (209), Expect = 4e-17
 Identities = 56/159 (35%), Positives = 85/159 (53%), Gaps = 3/159 (1%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQL-GVPVNDKDDAGWSPLHI 79
           E  + IL++ +    +D D R  L  A  AG  E V+ L     V   D +    +PLH 
Sbjct: 633 EAVQQILSESTPIRTSDVDYR--LLEASKAGDLETVKQLCSSQNVNCRDLEGRHSTPLHF 690

Query: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
           AA   R  +V+ LL  GA V+A ++ G  PLH A S   +E+A +L+  GA+ +  D ++
Sbjct: 691 AAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWK 750

Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178
            T +H AAAKG  ++  +LL + A    ++ +GNTPL L
Sbjct: 751 FTPLHEAAAKGKYEICKLLLKHGADPTKKNRDGNTPLDL 789



 Score = 84.7 bits (208), Expect = 6e-17
 Identities = 69/230 (30%), Positives = 94/230 (40%), Gaps = 54/230 (23%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--- 93
           D      LH ACS GH E+V  LL  G   N +D+  ++PLH AA  G+ ++   LL   
Sbjct: 246 DDGGLIPLHNACSFGHAEVVSLLLCQGADPNARDNWNYTPLHEAAIKGKIDVCIVLLQHG 305

Query: 94  ---------GKGA----------------------------------------QVNAVNQ 104
                    GK A                                         VN    
Sbjct: 306 ADPNIRNTDGKSALDLADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHAS 365

Query: 105 NG--CTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
           +G   TPLH AA  NR  I  +LL+ GA+  AKD      +H A + G+ ++  +LL + 
Sbjct: 366 DGRKSTPLHLAAGYNRVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHG 425

Query: 163 ASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A  N  D    TPLH A  + RVE   LL+S GA   + N   K+ + +A
Sbjct: 426 ACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475



 Score = 78.6 bits (192), Expect = 4e-15
 Identities = 63/207 (30%), Positives = 90/207 (43%), Gaps = 29/207 (14%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI----------------- 79
           D   +TALH A  AGH +    LL  G   +     G++   +                 
Sbjct: 588 DTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQILSESTPIRT 647

Query: 80  ---------AASAGRDEIVKALLGKGAQVNAVNQNG--CTPLHYAASKNRHEIAVMLLEG 128
                    A+ AG  E VK L      VN  +  G   TPLH+AA  NR  +   LL  
Sbjct: 648 SDVDYRLLEASKAGDLETVKQLCSS-QNVNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHH 706

Query: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEA 188
           GA+  AKD      +H A + G+ ++  +L+ + AS N+ D    TPLH A  + + E  
Sbjct: 707 GADVHAKDKGGLVPLHNACSYGHYEVAELLVRHGASVNVADLWKFTPLHEAAAKGKYEIC 766

Query: 189 KLLVSQGASIYIENKEEKTPLQVAKGG 215
           KLL+  GA    +N++  TPL + K G
Sbjct: 767 KLLLKHGADPTKKNRDGNTPLDLVKEG 793



 Score = 77.8 bits (190), Expect = 7e-15
 Identities = 51/155 (32%), Positives = 83/155 (53%), Gaps = 2/155 (1%)

Query: 27  LADKSL-ATRTDQDSRTALHWACSAGHTE-IVEFLLQLGVPVNDKDDAGWSPLHIAASAG 84
           LAD S  A  T +  +  L  A  +G+ E ++  L  L V  +  D    +PLH+AA   
Sbjct: 321 LADPSAKAVLTGEYKKDELLEAARSGNEEKLMALLTPLNVNCHASDGRKSTPLHLAAGYN 380

Query: 85  RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMH 144
           R  IV+ LL  GA V+A ++ G  PLH A S   +E+  +LL+ GA  +A D ++ T +H
Sbjct: 381 RVRIVQLLLQHGADVHAKDKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLH 440

Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
            AA+K  +++  +LL + A   + +  G + + +A
Sbjct: 441 EAASKNRVEVCSLLLSHGADPTLVNCHGKSAVDMA 475



 Score = 77.0 bits (188), Expect = 1e-14
 Identities = 44/120 (36%), Positives = 68/120 (56%), Gaps = 2/120 (1%)

Query: 66  VNDKDDAGWS--PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAV 123
           +N +D  G +  PLH+AA     E+ + LL  GA VNA ++ G  PLH AAS    +IA 
Sbjct: 828 INCRDTQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAA 887

Query: 124 MLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEE 183
           +L++     +A D +  T +H AA KG  ++  +LL + A   +++ EG TPL LA  ++
Sbjct: 888 LLIKYNTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADD 947



 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 63/230 (27%), Positives = 106/230 (46%), Gaps = 33/230 (14%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHT---EIVEFLLQLGVPVNDKD 70
           A    L ++K++ LA + +  +  Q   TALH A ++ H    ++ E LL+ G  VN+K+
Sbjct: 497 AREADLAKVKKT-LALEIINFKQPQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKN 555

Query: 71  DAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130
               +PLH+AA    +++++ L   GA++NA++  G T LH AA     +   +LL  G+
Sbjct: 556 KDFMTPLHVAAERAHNDVMEVLHKHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGS 615

Query: 131 NPDAKDHYEATA--------------------------MHRAAAKGNLKMIHILLYYKAS 164
           +P        TA                          +  A+  G+L+ +   L    +
Sbjct: 616 DPSIISLQGFTAAQMGNEAVQQILSESTPIRTSDVDYRLLEASKAGDLETVK-QLCSSQN 674

Query: 165 TNIQDTEG--NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            N +D EG  +TPLH A    RV   + L+  GA ++ ++K    PL  A
Sbjct: 675 VNCRDLEGRHSTPLHFAAGYNRVSVVEYLLHHGADVHAKDKGGLVPLHNA 724



 Score = 73.9 bits (180), Expect = 1e-13
 Identities = 43/113 (38%), Positives = 59/113 (52%)

Query: 36  TDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           T   + T LH A    + E+ E+LL+ G  VN +D  G  PLH AAS G  +I   L+  
Sbjct: 833 TQGRNSTPLHLAAGYNNLEVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKY 892

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAA 148
              VNA ++   TPLH AA K R ++  +LL  GA+P  K+    T +  A A
Sbjct: 893 NTCVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATA 945



 Score = 64.7 bits (156), Expect = 6e-11
 Identities = 65/241 (26%), Positives = 96/241 (39%), Gaps = 57/241 (23%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--- 93
           D+     LH ACS GH E+ E LL+ G  VN  D   ++PLH AAS  R E+   LL   
Sbjct: 399 DKGGLVPLHNACSYGHYEVTELLLKHGACVNAMDLWQFTPLHEAASKNRVEVCSLLLSHG 458

Query: 94  ---------GKGA--------------------------------------QVNAVN--- 103
                    GK A                                       +  +N   
Sbjct: 459 ADPTLVNCHGKSAVDMAPTPELRERLTYEFKGHSLLQAAREADLAKVKKTLALEIINFKQ 518

Query: 104 -QNGCTPLHYAASK---NRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILL 159
            Q+  T LH A +     R ++  +LL  GAN + K+    T +H AA + +  ++ +L 
Sbjct: 519 PQSHETALHCAVASLHPKRKQVTELLLRKGANVNEKNKDFMTPLHVAAERAHNDVMEVLH 578

Query: 160 YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAKGGLGLI 219
            + A  N  DT G T LH A     ++  +LL+S G+   I + +  T  Q+    +  I
Sbjct: 579 KHGAKMNALDTLGQTALHRAALAGHLQTCRLLLSYGSDPSIISLQGFTAAQMGNEAVQQI 638

Query: 220 L 220
           L
Sbjct: 639 L 639



 Score = 56.2 bits (134), Expect = 2e-08
 Identities = 35/112 (31%), Positives = 51/112 (45%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+ E +L   +     D+     LH A S GH +I   L++    VN  D   ++PLH A
Sbjct: 851 EVAEYLLEHGADVNAQDKGGLIPLHNAASYGHVDIAALLIKYNTCVNATDKWAFTPLHEA 910

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
           A  GR ++   LL  GA     NQ G TPL  A + +   + +  +   A P
Sbjct: 911 AQKGRTQLCALLLAHGADPTMKNQEGQTPLDLATADDIRALLIDAMPPEALP 962


>gi|224465233 euchromatic histone-lysine N-methyltransferase 1
           isoform 1 [Homo sapiens]
          Length = 1298

 Score =  104 bits (259), Expect = 7e-23
 Identities = 60/176 (34%), Positives = 97/176 (55%), Gaps = 1/176 (0%)

Query: 38  QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
           +D RT L  A    H E V++L++ G  V+ KD  G + LH+AA  G  E+V+ LL  G 
Sbjct: 804 EDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQ 863

Query: 98  Q-VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
             VN  +  G TP+ +A      ++  +LL  G++ + +D+ E   +H AA  G + +  
Sbjct: 864 MDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAE 923

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           ILL  K   +  +  G++PLH+A  E R +   L +S+ + + ++NKE +TPLQ A
Sbjct: 924 ILLAAKCDLHAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCA 979



 Score = 85.1 bits (209), Expect = 4e-17
 Identities = 63/196 (32%), Positives = 100/196 (51%), Gaps = 3/196 (1%)

Query: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG--WSPL 77
           E L+ +++A  S   +  +     L+++   G  + V  +L  G+  N K +     SPL
Sbjct: 718 ETLESALIALDSEKPKKLRFHPKQLYFSARQGELQKVLLMLVDGIDPNFKMEHQNKRSPL 777

Query: 78  HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH 137
           H AA AG  +I   L+  GA ++  +++  TPL  AA  N  E    L++ GA  D KD 
Sbjct: 778 HAAAEAGHVDICHMLVQAGANIDTCSEDQRTPLMEAAENNHLEAVKYLIKAGALVDPKDA 837

Query: 138 YEATAMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196
             +T +H AA KG+ +++  LL   +   N QD  G TP+  A + + V+  KLL+S+G+
Sbjct: 838 EGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDGGWTPMIWATEYKHVDLVKLLLSKGS 897

Query: 197 SIYIENKEEKTPLQVA 212
            I I + EE   L  A
Sbjct: 898 DINIRDNEENICLHWA 913



 Score = 67.0 bits (162), Expect = 1e-11
 Identities = 50/168 (29%), Positives = 76/168 (45%), Gaps = 35/168 (20%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG-VPVNDKDDA 72
           A +  LE +K  I A  +L    D +  T LH A   GH E+V++LL  G + VN +DD 
Sbjct: 814 AENNHLEAVKYLIKAG-ALVDPKDAEGSTCLHLAAKKGHYEVVQYLLSNGQMDVNCQDDG 872

Query: 73  GWSPLHIAASAGRDEIVKALLGKGAQVN-------------------------------- 100
           GW+P+  A      ++VK LL KG+ +N                                
Sbjct: 873 GWTPMIWATEYKHVDLVKLLLSKGSDINIRDNEENICLHWAAFSGCVDIAEILLAAKCDL 932

Query: 101 -AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAA 147
            AVN +G +PLH AA +NR++  V+ L   ++   K+    T +  A+
Sbjct: 933 HAVNIHGDSPLHIAARENRYDCVVLFLSRDSDVTLKNKEGETPLQCAS 980


>gi|223634006 hypothetical protein LOC441869 [Homo sapiens]
          Length = 399

 Score =  103 bits (258), Expect = 9e-23
 Identities = 69/192 (35%), Positives = 105/192 (54%), Gaps = 14/192 (7%)

Query: 38  QDSR--TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK 95
           +D+R  TA HWA + G   ++E L   G  ++         L +AA+AGR   ++ LL +
Sbjct: 173 EDARGWTAAHWAAAGGRLAVLELLAAGGAGLD-------GALLVAAAAGRGAALRFLLAR 225

Query: 96  GAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
           GA+V+A +  G T L  AA+  R +   +LL  GA+P  +D +  +A+HRAAA+G+L  +
Sbjct: 226 GARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAV 285

Query: 156 HILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK-- 213
            +L+   A  + +DT G TPLH A  E  VE A  L+ +GA +       KTPL +A   
Sbjct: 286 QLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHLAAER 345

Query: 214 ---GGLGLILKR 222
                +GL+L R
Sbjct: 346 GHGPTVGLLLSR 357



 Score = 85.5 bits (210), Expect = 3e-17
 Identities = 72/237 (30%), Positives = 103/237 (43%), Gaps = 32/237 (13%)

Query: 22  LKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAA 81
           L   +L   +     D   RT LH A   GH  +V  LLQ G PV   D AG + LH AA
Sbjct: 56  LVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRAGRTALHEAA 115

Query: 82  SAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE----GGANPDAKDH 137
             G   + + LL +GA   A +  G TPLH+AA+     +A  LLE    G A  +A+D 
Sbjct: 116 WHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAPGPGPAAAEAEDA 175

Query: 138 YEATAMHRAAAKGNLKMIHI--------------------------LLYYKASTNIQDTE 171
              TA H AAA G L ++ +                          LL   A  + +D  
Sbjct: 176 RGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLLARGARVDARDGA 235

Query: 172 GNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQ--VAKGGLGLILKRMVEG 226
           G T L LA    R ++ ++L+  GA   I ++  ++ L    A+G L  +   + +G
Sbjct: 236 GATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLLAVQLLVTQG 292



 Score = 85.1 bits (209), Expect = 4e-17
 Identities = 67/206 (32%), Positives = 91/206 (44%), Gaps = 30/206 (14%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALL--- 93
           D+  RTALH A   GH+ + E LLQ G     +   G +PLH AA+ G   +   LL   
Sbjct: 104 DRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPLHWAAALGHTLLAARLLEAP 163

Query: 94  GKG-AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG------------------------ 128
           G G A   A +  G T  H+AA+  R  +  +L  G                        
Sbjct: 164 GPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGLDGALLVAAAAGRGAALRFLL 223

Query: 129 --GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVE 186
             GA  DA+D   ATA+  AAA G  + I +LL + A   I+D  G + LH A     + 
Sbjct: 224 ARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGHLL 283

Query: 187 EAKLLVSQGASIYIENKEEKTPLQVA 212
             +LLV+QGA +   +    TPL  A
Sbjct: 284 AVQLLVTQGAEVDARDTLGLTPLHHA 309



 Score = 84.0 bits (206), Expect = 1e-16
 Identities = 57/156 (36%), Positives = 86/156 (55%), Gaps = 2/156 (1%)

Query: 43  ALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           AL  A +AG    + FLL  G  V+ +D AG + L +AA+ GR + ++ LLG GA     
Sbjct: 206 ALLVAAAAGRGAALRFLLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIR 265

Query: 103 NQNGCTPLHYAASKNRHEIAVMLL-EGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
           +++G + LH AA++  H +AV LL   GA  DA+D    T +H A+ +G++++   LL  
Sbjct: 266 DRHGRSALHRAAARG-HLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDR 324

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197
            A  +       TPLHLA +        LL+S+GAS
Sbjct: 325 GAQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGAS 360



 Score = 80.9 bits (198), Expect = 8e-16
 Identities = 60/179 (33%), Positives = 90/179 (50%), Gaps = 8/179 (4%)

Query: 28  ADKSLATRTDQDSRTA----LHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASA 83
           ++++L TRT+  S       L  A   G   +V  LL+ G  V ++D AG +PLH+A   
Sbjct: 25  SEEALGTRTEGPSVVQGWGHLLQAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLR 84

Query: 84  GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
           G   +V+ LL +GA V AV++ G T LH AA      +A +LL+ GA+  A+     T +
Sbjct: 85  GHAPLVRLLLQRGAPVGAVDRAGRTALHEAAWHGHSRVAELLLQRGASAAARSGTGLTPL 144

Query: 144 HRAAAKGNLKMIHILLYY----KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASI 198
           H AAA G+  +   LL       A+   +D  G T  H A    R+   +LL + GA +
Sbjct: 145 HWAAALGHTLLAARLLEAPGPGPAAAEAEDARGWTAAHWAAAGGRLAVLELLAAGGAGL 203



 Score = 73.2 bits (178), Expect = 2e-13
 Identities = 49/143 (34%), Positives = 75/143 (52%)

Query: 26  ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
           +LA  +     D    TAL  A + G ++ +E LL  G     +D  G S LH AA+ G 
Sbjct: 222 LLARGARVDARDGAGATALGLAAALGRSQDIEVLLGHGADPGIRDRHGRSALHRAAARGH 281

Query: 86  DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHR 145
              V+ L+ +GA+V+A +  G TPLH+A+ +   E+A  LL+ GA  DA      T +H 
Sbjct: 282 LLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRGAQVDATGWLRKTPLHL 341

Query: 146 AAAKGNLKMIHILLYYKASTNIQ 168
           AA +G+   + +LL   AS  ++
Sbjct: 342 AAERGHGPTVGLLLSRGASPTLR 364



 Score = 70.5 bits (171), Expect = 1e-12
 Identities = 39/106 (36%), Positives = 56/106 (52%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+  R+ALH A + GH   V+ L+  G  V+ +D  G +PLH A+  G  E+   LL +G
Sbjct: 266 DRHGRSALHRAAARGHLLAVQLLVTQGAEVDARDTLGLTPLHHASREGHVEVAGCLLDRG 325

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATA 142
           AQV+A      TPLH AA +       +LL  GA+P  +  +   A
Sbjct: 326 AQVDATGWLRKTPLHLAAERGHGPTVGLLLSRGASPTLRTQWAEVA 371



 Score = 33.1 bits (74), Expect = 0.20
 Identities = 21/68 (30%), Positives = 33/68 (48%)

Query: 145 RAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKE 204
           +A  +G   ++  LL   AS   +D  G TPLHLA         +LL+ +GA +   ++ 
Sbjct: 47  QAVWRGPAGLVTQLLRQGASVEERDHAGRTPLHLAVLRGHAPLVRLLLQRGAPVGAVDRA 106

Query: 205 EKTPLQVA 212
            +T L  A
Sbjct: 107 GRTALHEA 114


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  103 bits (257), Expect = 1e-22
 Identities = 65/195 (33%), Positives = 102/195 (52%), Gaps = 2/195 (1%)

Query: 18  KLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPL 77
           +L + K  +  D+ L     ++  T LH+  + G  E V  LL   V V+ +  +G++PL
Sbjct: 342 QLSDRKNLVPRDEELCIY--ENKVTPLHFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPL 399

Query: 78  HIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDH 137
            IAA   + ++   LL  GA  N V+++G  PLH+AA       A +LL+ GA  DA++ 
Sbjct: 400 LIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 459

Query: 138 YEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGAS 197
              T +H AA      +  +L+  +A  N+ + EG TPLH+A     V   KLL SQGA 
Sbjct: 460 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAE 519

Query: 198 IYIENKEEKTPLQVA 212
           +  + +  +TPL +A
Sbjct: 520 LDAQQRNLRTPLHLA 534



 Score = 97.4 bits (241), Expect = 9e-21
 Identities = 65/209 (31%), Positives = 98/209 (46%), Gaps = 2/209 (0%)

Query: 13  LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72
           +A   +  +L   +LA  + A R D+D    LH+A   G       LL  G  V+ ++  
Sbjct: 401 IAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQERE 460

Query: 73  GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
           GW+PLH+AA    + + + L+ + A  N     G TPLH AA      +  +L   GA  
Sbjct: 461 GWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAEL 520

Query: 133 DAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLV 192
           DA+     T +H A  +G ++ I  LL   A  +  D  G  PLH A    +    K+L+
Sbjct: 521 DAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLL 580

Query: 193 SQGASIYIENKEEKTPLQVA--KGGLGLI 219
             GAS+ +   +  TPL +A  KG L +I
Sbjct: 581 RYGASLELPTHQGWTPLHLAAYKGHLEII 609



 Score = 97.1 bits (240), Expect = 1e-20
 Identities = 67/186 (36%), Positives = 87/186 (46%), Gaps = 1/186 (0%)

Query: 41  RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100
           RT LH A   G    ++ LL+ G   +  D +G+ PLH AA+ G+  I K LL  GA + 
Sbjct: 528 RTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLE 587

Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY 160
                G TPLH AA K   EI  +L E  AN  A      T +H AA  G   ++  LL 
Sbjct: 588 LPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQ 647

Query: 161 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK-GGLGLI 219
             A  N  +  G TPLHLA           L+   A+++  NK   TP  +A   G   I
Sbjct: 648 CGADPNAAEQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAI 707

Query: 220 LKRMVE 225
           LK +VE
Sbjct: 708 LKVLVE 713



 Score = 94.7 bits (234), Expect = 6e-20
 Identities = 60/201 (29%), Positives = 99/201 (49%)

Query: 12  NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
           +LA     E +   +++ ++     + + +T LH A   GH  +V+ L   G  ++ +  
Sbjct: 466 HLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVAAYFGHVSLVKLLTSQGAELDAQQR 525

Query: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
              +PLH+A   G+   ++ LL  GA  +A++Q+G  PLH AA++ ++ I  MLL  GA+
Sbjct: 526 NLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGAS 585

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
            +   H   T +H AA KG+L++IH+L    A+         TPLHLA           L
Sbjct: 586 LELPTHQGWTPLHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSAL 645

Query: 192 VSQGASIYIENKEEKTPLQVA 212
           +  GA      +   TPL +A
Sbjct: 646 LQCGADPNAAEQSGWTPLHLA 666



 Score = 94.0 bits (232), Expect = 9e-20
 Identities = 60/196 (30%), Positives = 95/196 (48%), Gaps = 1/196 (0%)

Query: 17  GKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSP 76
           GK+  ++  +L   ++    DQ     LH A + G   I + LL+ G  +      GW+P
Sbjct: 538 GKVRAIQH-LLKSGAVPDALDQSGYGPLHTAAARGKYLICKMLLRYGASLELPTHQGWTP 596

Query: 77  LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKD 136
           LH+AA  G  EI+  L    A + A+     TPLH AA      +   LL+ GA+P+A +
Sbjct: 597 LHLAAYKGHLEIIHLLAESHANMGALGAVNWTPLHLAARHGEEAVVSALLQCGADPNAAE 656

Query: 137 HYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA 196
               T +H A  +     +  LL + A+ + ++  G TP HLA  +      K+LV  GA
Sbjct: 657 QSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAGA 716

Query: 197 SIYIENKEEKTPLQVA 212
            + +++    TPLQ+A
Sbjct: 717 QLDVQDGVSCTPLQLA 732



 Score = 91.7 bits (226), Expect = 5e-19
 Identities = 64/199 (32%), Positives = 94/199 (47%), Gaps = 6/199 (3%)

Query: 32  LATRTDQDSRTALHW-----ACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRD 86
           LA   D D +TA  +     A      ++   LL  G   N  D+ GW+PLH AA  G D
Sbjct: 382 LAHEVDVDCQTASGYTPLLIAAQDQQPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDD 441

Query: 87  EIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRA 146
              + LL  GA V+A  + G TPLH AA  N   +A +L+   A+P+  +    T +H A
Sbjct: 442 GTARLLLDHGACVDAQEREGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTPLHVA 501

Query: 147 AAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEK 206
           A  G++ ++ +L    A  + Q     TPLHLA +  +V   + L+  GA     ++   
Sbjct: 502 AYFGHVSLVKLLTSQGAELDAQQRNLRTPLHLAVERGKVRAIQHLLKSGAVPDALDQSGY 561

Query: 207 TPLQVAKG-GLGLILKRMV 224
            PL  A   G  LI K ++
Sbjct: 562 GPLHTAAARGKYLICKMLL 580



 Score = 49.7 bits (117), Expect = 2e-06
 Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 1/92 (1%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           +Q   T LH A        V  LL+    V+ ++  GW+P H+AA  G   I+K L+  G
Sbjct: 656 EQSGWTPLHLAVQRSTFLSVINLLEHHANVHARNKVGWTPAHLAALKGNTAILKVLVEAG 715

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128
           AQ++  +   CTPL  A  ++R +  +  LEG
Sbjct: 716 AQLDVQDGVSCTPLQLAL-RSRKQGIMSFLEG 746



 Score = 32.0 bits (71), Expect = 0.44
 Identities = 17/58 (29%), Positives = 30/58 (51%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQV 99
           T  H A   G+T I++ L++ G  ++ +D    +PL +A  + +  I+  L GK   V
Sbjct: 694 TPAHLAALKGNTAILKVLVEAGAQLDVQDGVSCTPLQLALRSRKQGIMSFLEGKEPSV 751


>gi|89363047 death-associated protein kinase 1 [Homo sapiens]
          Length = 1430

 Score =  102 bits (255), Expect = 2e-22
 Identities = 61/176 (34%), Positives = 88/176 (50%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+    ALH A   GH ++ + L   G   N +D    +PLH AA  G   + KAL   G
Sbjct: 442 DKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYYSVAKALCEAG 501

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
             VN  N+ G TPL  A+++  H+I   L E GA+ +A D     A+H A  +  +++I 
Sbjct: 502 CNVNIKNREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIK 561

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            LL      + QD  GNTPLH+AC +  +     L     ++ I NK  +TPL +A
Sbjct: 562 TLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617



 Score = 98.6 bits (244), Expect = 4e-21
 Identities = 56/176 (31%), Positives = 92/176 (52%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+    A++WA   GH + ++FL +   P++ KD +G   LH+AA  G  ++ + L   G
Sbjct: 409 DKGGSNAVYWAARHGHVDTLKFLSENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFG 468

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
           +  N  ++   TPLH AA    + +A  L E G N + K+    T +  A+A+G   ++ 
Sbjct: 469 SNPNIQDKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVE 528

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            L  + A  N  D +G+  LHLA    ++E  K L+SQG  +  +++   TPL VA
Sbjct: 529 CLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVA 584



 Score = 89.7 bits (221), Expect = 2e-18
 Identities = 54/177 (30%), Positives = 90/177 (50%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D++  T LH A   G+  + + L + G  VN K+  G +PL  A++ G  +IV+ L   G
Sbjct: 475 DKEEETPLHCAAWHGYYSVAKALCEAGCNVNIKNREGETPLLTASARGYHDIVECLAEHG 534

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
           A +NA +++G   LH A  + + E+   LL  G   D +D +  T +H A   GN+ ++ 
Sbjct: 535 ADLNACDKDGHIALHLAVRRCQMEVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVV 594

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
            L     + +I +  G TPLHLA +   ++  + L   GAS+     + KT   +A+
Sbjct: 595 ALCEANCNLDISNKYGRTPLHLAANNGILDVVRYLCLMGASVEALTTDGKTAEDLAR 651



 Score = 81.3 bits (199), Expect = 6e-16
 Identities = 52/155 (33%), Positives = 75/155 (48%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           +++  T L  A + G+ +IVE L + G  +N  D  G   LH+A    + E++K LL +G
Sbjct: 508 NREGETPLLTASARGYHDIVECLAEHGADLNACDKDGHIALHLAVRRCQMEVIKTLLSQG 567

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
             V+  +++G TPLH A       I V L E   N D  + Y  T +H AA  G L ++ 
Sbjct: 568 CFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLAANNGILDVVR 627

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
            L    AS     T+G T   LA  E+    A LL
Sbjct: 628 YLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662



 Score = 80.1 bits (196), Expect = 1e-15
 Identities = 47/147 (31%), Positives = 75/147 (51%)

Query: 66  VNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
           VN  +  G  PL IAA  G  +I++ L+ +G++++  ++ G   +++AA     +    L
Sbjct: 372 VNQPNKHGTPPLLIAAGCGNIQILQLLIKRGSRIDVQDKGGSNAVYWAARHGHVDTLKFL 431

Query: 126 LEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERV 185
            E     D KD     A+H AA  G+  +  +L  + ++ NIQD E  TPLH A      
Sbjct: 432 SENKCPLDVKDKSGEMALHVAARYGHADVAQLLCSFGSNPNIQDKEEETPLHCAAWHGYY 491

Query: 186 EEAKLLVSQGASIYIENKEEKTPLQVA 212
             AK L   G ++ I+N+E +TPL  A
Sbjct: 492 SVAKALCEAGCNVNIKNREGETPLLTA 518



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 31/105 (29%), Positives = 53/105 (50%)

Query: 21  ELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIA 80
           E+ +++L+        D+   T LH AC  G+  IV  L +    ++  +  G +PLH+A
Sbjct: 558 EVIKTLLSQGCFVDYQDRHGNTPLHVACKDGNMPIVVALCEANCNLDISNKYGRTPLHLA 617

Query: 81  ASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVML 125
           A+ G  ++V+ L   GA V A+  +G T    A S+    +A +L
Sbjct: 618 ANNGILDVVRYLCLMGASVEALTTDGKTAEDLARSEQHEHVAGLL 662


>gi|41327752 diabetes related ankyrin repeat protein [Homo sapiens]
          Length = 305

 Score =  102 bits (255), Expect = 2e-22
 Identities = 61/165 (36%), Positives = 89/165 (53%)

Query: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHI 79
           E L +  L D       D+  RTALHWAC  GH+++V  LL  G  V+ +D    +P+  
Sbjct: 124 EYLIDKYLTDGGDPNAHDKLHRTALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFW 183

Query: 80  AASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYE 139
           A   G   I+K LL +GA+VNA ++ G TPLH A      +    L+E GA+ +A+D   
Sbjct: 184 ACRGGHLVILKQLLNQGARVNARDKIGSTPLHVAVRTRHPDCLEHLIECGAHLNAQDKEG 243

Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEER 184
            TA+H A   G+ K + +LL Y A   +++    TP+ LA D +R
Sbjct: 244 DTALHEAVRHGSYKAMKLLLLYGAELGVRNAASVTPVQLARDWQR 288



 Score = 31.2 bits (69), Expect = 0.75
 Identities = 27/111 (24%), Positives = 48/111 (43%), Gaps = 4/111 (3%)

Query: 118 RHEIAVMLLEGGANPDAKDHYEATAMH---RAAAKGNLKMIHILLYYKASTNIQDTEGNT 174
           RH +     E    P ++   E   +    +AAA+    +I   L      N  D    T
Sbjct: 87  RHRVPPRKPEPLVKPQSQAQVEPVGLEMFLKAAAENQEYLIDKYLTDGGDPNAHDKLHRT 146

Query: 175 PLHLACDEERVEEAKLLVSQGASIYIENKEEKTPL-QVAKGGLGLILKRMV 224
            LH AC +   +    L+  GA++   +  ++TP+    +GG  +ILK+++
Sbjct: 147 ALHWACLKGHSQLVNKLLVAGATVDARDLLDRTPVFWACRGGHLVILKQLL 197


>gi|219842212 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform a [Homo sapiens]
          Length = 1030

 Score =  101 bits (252), Expect = 5e-22
 Identities = 67/201 (33%), Positives = 97/201 (48%), Gaps = 27/201 (13%)

Query: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
           D  TALH AC   + ++V+FL++ G  +N  D+ GW PLH AAS G  +I + L+G+GA 
Sbjct: 72  DGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAH 131

Query: 99  VNAVNQNGCTPLHYAASKNRHEIA--------------------VMLLE-------GGAN 131
           V AVN  G TPL  A  +   E+                     +ML +       G  N
Sbjct: 132 VGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHIN 191

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
                    TA+H AAAKG  +++ +L+      NI+D +G TPLH A    + E  ++L
Sbjct: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251

Query: 192 VSQGASIYIENKEEKTPLQVA 212
           V     + + NK  +T   VA
Sbjct: 252 VDNLCDMEMVNKVGQTAFDVA 272



 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 4/140 (2%)

Query: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128
           K D G   L   +S   DE++K LL +GA +N  N +G T LH A   +  ++   L+E 
Sbjct: 37  KFDDGAVFLAACSSGDTDEVLK-LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVEN 95

Query: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEE- 187
           GAN +  D+     +H AA+ G L +   L+   A     ++EG+TPL +A +EE +EE 
Sbjct: 96  GANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA-EEEAMEEL 154

Query: 188 -AKLLVSQGASIYIENKEEK 206
               +  QG  I    KEE+
Sbjct: 155 LQNEVNRQGVDIEAARKEEE 174



 Score = 62.0 bits (149), Expect = 4e-10
 Identities = 62/210 (29%), Positives = 87/210 (41%), Gaps = 27/210 (12%)

Query: 30  KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
           K   T+   D       ACS+G T+ V  LL  G  +N  +  G + LH A      ++V
Sbjct: 30  KRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMV 89

Query: 90  KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA--------KDHYEAT 141
           K L+  GA +N  +  G  PLH AAS    +IA  L+  GA+  A         D  E  
Sbjct: 90  KFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE 149

Query: 142 AMH--------------RAAAKGNLK-MIHILLYYKASTNIQDT----EGNTPLHLACDE 182
           AM                AA K   + M+     +  S +I D      G T LH+A  +
Sbjct: 150 AMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAK 209

Query: 183 ERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
              E  KLL+  G  + I++ +  TPL  A
Sbjct: 210 GYTEVLKLLIQAGYDVNIKDYDGWTPLHAA 239



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 49/200 (24%), Positives = 88/200 (44%), Gaps = 28/200 (14%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK- 95
           D +    LH A S G+ +I EFL+  G  V   +  G +PL IA     +E+++  + + 
Sbjct: 103 DNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQ 162

Query: 96  GAQVNAVNQ--------------------------NGCTPLHYAASKNRHEIAVMLLEGG 129
           G  + A  +                          +G T LH AA+K   E+  +L++ G
Sbjct: 163 GVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAG 222

Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAK 189
            + + KD+   T +H AA  G  +   IL+       + +  G T   +A DE+ +   +
Sbjct: 223 YDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-DEDILGYLE 281

Query: 190 LLVSQGASIYIENKEEKTPL 209
            L  +   ++ E +++K+PL
Sbjct: 282 ELQKKQNLLHSEKRDKKSPL 301



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 33/101 (32%), Positives = 51/101 (50%)

Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172
           A S    +  + LL  GA+ +  +    TA+H+A    N+ M+  L+   A+ N  D EG
Sbjct: 47  ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106

Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
             PLH A     ++ A+ L+ QGA +   N E  TPL +A+
Sbjct: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 147


>gi|4505317 protein phosphatase 1, regulatory (inhibitor) subunit
           12A isoform a [Homo sapiens]
          Length = 1030

 Score =  101 bits (252), Expect = 5e-22
 Identities = 67/201 (33%), Positives = 97/201 (48%), Gaps = 27/201 (13%)

Query: 39  DSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQ 98
           D  TALH AC   + ++V+FL++ G  +N  D+ GW PLH AAS G  +I + L+G+GA 
Sbjct: 72  DGLTALHQACIDDNVDMVKFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAH 131

Query: 99  VNAVNQNGCTPLHYAASKNRHEIA--------------------VMLLE-------GGAN 131
           V AVN  G TPL  A  +   E+                     +ML +       G  N
Sbjct: 132 VGAVNSEGDTPLDIAEEEAMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHIN 191

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
                    TA+H AAAKG  +++ +L+      NI+D +G TPLH A    + E  ++L
Sbjct: 192 DVRHAKSGGTALHVAAAKGYTEVLKLLIQAGYDVNIKDYDGWTPLHAAAHWGKEEACRIL 251

Query: 192 VSQGASIYIENKEEKTPLQVA 212
           V     + + NK  +T   VA
Sbjct: 252 VDNLCDMEMVNKVGQTAFDVA 272



 Score = 65.9 bits (159), Expect = 3e-11
 Identities = 48/140 (34%), Positives = 72/140 (51%), Gaps = 4/140 (2%)

Query: 69  KDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEG 128
           K D G   L   +S   DE++K LL +GA +N  N +G T LH A   +  ++   L+E 
Sbjct: 37  KFDDGAVFLAACSSGDTDEVLK-LLHRGADINYANVDGLTALHQACIDDNVDMVKFLVEN 95

Query: 129 GANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEE- 187
           GAN +  D+     +H AA+ G L +   L+   A     ++EG+TPL +A +EE +EE 
Sbjct: 96  GANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIA-EEEAMEEL 154

Query: 188 -AKLLVSQGASIYIENKEEK 206
               +  QG  I    KEE+
Sbjct: 155 LQNEVNRQGVDIEAARKEEE 174



 Score = 62.0 bits (149), Expect = 4e-10
 Identities = 62/210 (29%), Positives = 87/210 (41%), Gaps = 27/210 (12%)

Query: 30  KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
           K   T+   D       ACS+G T+ V  LL  G  +N  +  G + LH A      ++V
Sbjct: 30  KRQKTKVKFDDGAVFLAACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMV 89

Query: 90  KALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA--------KDHYEAT 141
           K L+  GA +N  +  G  PLH AAS    +IA  L+  GA+  A         D  E  
Sbjct: 90  KFLVENGANINQPDNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEE 149

Query: 142 AMH--------------RAAAKGNLK-MIHILLYYKASTNIQDT----EGNTPLHLACDE 182
           AM                AA K   + M+     +  S +I D      G T LH+A  +
Sbjct: 150 AMEELLQNEVNRQGVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAK 209

Query: 183 ERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
              E  KLL+  G  + I++ +  TPL  A
Sbjct: 210 GYTEVLKLLIQAGYDVNIKDYDGWTPLHAA 239



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 49/200 (24%), Positives = 88/200 (44%), Gaps = 28/200 (14%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGK- 95
           D +    LH A S G+ +I EFL+  G  V   +  G +PL IA     +E+++  + + 
Sbjct: 103 DNEGWIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAEEEAMEELLQNEVNRQ 162

Query: 96  GAQVNAVNQ--------------------------NGCTPLHYAASKNRHEIAVMLLEGG 129
           G  + A  +                          +G T LH AA+K   E+  +L++ G
Sbjct: 163 GVDIEAARKEEERIMLRDARQWLNSGHINDVRHAKSGGTALHVAAAKGYTEVLKLLIQAG 222

Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAK 189
            + + KD+   T +H AA  G  +   IL+       + +  G T   +A DE+ +   +
Sbjct: 223 YDVNIKDYDGWTPLHAAAHWGKEEACRILVDNLCDMEMVNKVGQTAFDVA-DEDILGYLE 281

Query: 190 LLVSQGASIYIENKEEKTPL 209
            L  +   ++ E +++K+PL
Sbjct: 282 ELQKKQNLLHSEKRDKKSPL 301



 Score = 53.5 bits (127), Expect = 1e-07
 Identities = 33/101 (32%), Positives = 51/101 (50%)

Query: 113 AASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEG 172
           A S    +  + LL  GA+ +  +    TA+H+A    N+ M+  L+   A+ N  D EG
Sbjct: 47  ACSSGDTDEVLKLLHRGADINYANVDGLTALHQACIDDNVDMVKFLVENGANINQPDNEG 106

Query: 173 NTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
             PLH A     ++ A+ L+ QGA +   N E  TPL +A+
Sbjct: 107 WIPLHAAASCGYLDIAEFLIGQGAHVGAVNSEGDTPLDIAE 147


>gi|96975023 ankyrin repeat and death domain containing 1A [Homo
           sapiens]
          Length = 522

 Score =  101 bits (252), Expect = 5e-22
 Identities = 53/176 (30%), Positives = 92/176 (52%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D++  TALH A   GH  +++ L+ +G+ + +++  G + LH AA     + V+ LL  G
Sbjct: 189 DKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAG 248

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
           + VNA+ Q   + LHYAA     +++ +L+  G   +  DH  A+ +H A       ++ 
Sbjct: 249 STVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVR 308

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +L+   +  N  D    TPLHLA +    + A +L+  G  + + +K+ KT L VA
Sbjct: 309 LLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVA 364



 Score = 92.4 bits (228), Expect = 3e-19
 Identities = 62/188 (32%), Positives = 91/188 (48%), Gaps = 14/188 (7%)

Query: 41  RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG----------WSPLHIAASAGRDEIVK 90
           R ALHWA  AGH + V  LL+    V+++D  G           + L ++A  G   I++
Sbjct: 49  RVALHWAAGAGHEQAVRLLLEHEAAVDEEDAVGALTEARLCFGMNALLLSAWFGHLRILQ 108

Query: 91  ALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA---TAMHRAA 147
            L+  GA+++  +++G T LH AA K    +   ++E      A DH +    TA HRAA
Sbjct: 109 ILVNSGAKIHCESKDGLTLLHCAAQKGHVPVLAFIMED-LEDVALDHVDKLGRTAFHRAA 167

Query: 148 AKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKT 207
             G L  +  L+      N++D EGNT LHLA     +   + LV  G  +  +N E  T
Sbjct: 168 EHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIGLDLEEQNAEGLT 227

Query: 208 PLQVAKGG 215
            L  A GG
Sbjct: 228 ALHSAAGG 235



 Score = 90.1 bits (222), Expect = 1e-18
 Identities = 51/176 (28%), Positives = 87/176 (49%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+  RTA H A   G  + ++FL+  G   N KD  G + LH+AA  G   +++ L+  G
Sbjct: 156 DKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHLAAGRGHMAVLQRLVDIG 215

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
             +   N  G T LH AA  +  +   +LL  G+  +A      + +H AA  G+  +  
Sbjct: 216 LDLEEQNAEGLTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSR 275

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           +L++     N+ D +G +PLHLA         +LL++  + +   +  ++TPL +A
Sbjct: 276 VLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLA 331



 Score = 77.4 bits (189), Expect = 9e-15
 Identities = 44/151 (29%), Positives = 73/151 (48%)

Query: 42  TALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNA 101
           TALH A    H + V+ LL+ G  VN       S LH AA +G +++ + L+  G   N 
Sbjct: 227 TALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCANV 286

Query: 102 VNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYY 161
           V+  G +PLH A   N   +  +L+   ++ +A D+ + T +H AA      +  +LL  
Sbjct: 287 VDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLIA 346

Query: 162 KASTNIQDTEGNTPLHLACDEERVEEAKLLV 192
               N++D +G T L +A     V    +++
Sbjct: 347 GVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377



 Score = 68.9 bits (167), Expect = 3e-12
 Identities = 50/204 (24%), Positives = 91/204 (44%), Gaps = 5/204 (2%)

Query: 8   LMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVN 67
           L   + A  G   +  + +L   S      Q + + LH+A  +G  ++   L+  G   N
Sbjct: 226 LTALHSAAGGSHPDCVQLLLRAGSTVNALTQKNLSCLHYAALSGSEDVSRVLIHAGGCAN 285

Query: 68  DKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127
             D  G SPLH+A       +V+ L+   + VNAV+    TPLH AA     +IA MLL 
Sbjct: 286 VVDHQGASPLHLAVRHNFPALVRLLINSDSDVNAVDNRQQTPLHLAAEHAWQDIADMLLI 345

Query: 128 GGANPDAKDHYEATAMHRAAAKGNLKMIHILL-----YYKASTNIQDTEGNTPLHLACDE 182
            G + + +D    TA+  A    ++ ++ +++     Y     +  D  G +        
Sbjct: 346 AGVDLNLRDKQGKTALAVAVRSNHVSLVDMIIKADRFYRWEKDHPSDPSGKSLSFKQDHR 405

Query: 183 ERVEEAKLLVSQGASIYIENKEEK 206
           +  ++ + ++ + AS Y++ +E K
Sbjct: 406 QETQQLRSVLWRLASRYLQPREWK 429



 Score = 43.9 bits (102), Expect = 1e-04
 Identities = 46/195 (23%), Positives = 75/195 (38%), Gaps = 46/195 (23%)

Query: 77  LHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA------ 130
           LH AA       ++ L+G+     A N  G   LH+AA     +   +LLE  A      
Sbjct: 19  LHEAARQNNVGRMQELIGRRVNTRARNHVGRVALHWAAGAGHEQAVRLLLEHEAAVDEED 78

Query: 131 ---------------------------------NPDAKDHYEA----TAMHRAAAKGNLK 153
                                            N  AK H E+    T +H AA KG++ 
Sbjct: 79  AVGALTEARLCFGMNALLLSAWFGHLRILQILVNSGAKIHCESKDGLTLLHCAAQKGHVP 138

Query: 154 MIHILL--YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV 211
           ++  ++      + +  D  G T  H A +  +++    LV  G    +++KE  T L +
Sbjct: 139 VLAFIMEDLEDVALDHVDKLGRTAFHRAAEHGQLDALDFLVGSGCDHNVKDKEGNTALHL 198

Query: 212 AKG-GLGLILKRMVE 225
           A G G   +L+R+V+
Sbjct: 199 AAGRGHMAVLQRLVD 213



 Score = 42.7 bits (99), Expect = 3e-04
 Identities = 30/121 (24%), Positives = 49/121 (40%)

Query: 7   NLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPV 66
           NL   + A     E++   ++     A   D    + LH A       +V  L+     V
Sbjct: 258 NLSCLHYAALSGSEDVSRVLIHAGGCANVVDHQGASPLHLAVRHNFPALVRLLINSDSDV 317

Query: 67  NDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLL 126
           N  D+   +PLH+AA     +I   LL  G  +N  ++ G T L  A   N   +  M++
Sbjct: 318 NAVDNRQQTPLHLAAEHAWQDIADMLLIAGVDLNLRDKQGKTALAVAVRSNHVSLVDMII 377

Query: 127 E 127
           +
Sbjct: 378 K 378


>gi|14149716 protein phosphatase 1, regulatory subunit 12C [Homo
           sapiens]
          Length = 782

 Score =  100 bits (250), Expect = 8e-22
 Identities = 66/196 (33%), Positives = 99/196 (50%), Gaps = 27/196 (13%)

Query: 30  KSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIV 89
           +++   T+ D  +ALH AC   + E+V FL++ G  VN  D+ GW+PLH+AAS G  +I 
Sbjct: 91  RAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVAASCGYLDIA 150

Query: 90  KALLGKGAQVNAVNQNGCTPLHYAAS--------------------KNRHEIAVML---- 125
           + LL  GA + AVN +G  PL  A S                      R E  ++L    
Sbjct: 151 RYLLSHGANIAAVNSDGDLPLDLAESDAMEGLLKAEIARRGVDVEAAKRAEEELLLHDTR 210

Query: 126 --LEGGANPDAK-DHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDE 182
             L GGA P+A+     A+A+H AAAKG ++++ +LL       ++D +G TPLH A   
Sbjct: 211 CWLNGGAMPEARHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHW 270

Query: 183 ERVEEAKLLVSQGASI 198
              +  +LL   G  +
Sbjct: 271 GVEDACRLLAEHGGGM 286



 Score = 50.4 bits (119), Expect = 1e-06
 Identities = 31/94 (32%), Positives = 51/94 (54%), Gaps = 6/94 (6%)

Query: 126 LEGGANPDAKDHYEAT------AMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
           L+  A P A+   ++T      A+H+A    NL+++  L+   A+ N  D EG TPLH+A
Sbjct: 82  LDPAAPPPARAVLDSTNADGISALHQACIDENLEVVRFLVEQGATVNQADNEGWTPLHVA 141

Query: 180 CDEERVEEAKLLVSQGASIYIENKEEKTPLQVAK 213
                ++ A+ L+S GA+I   N +   PL +A+
Sbjct: 142 ASCGYLDIARYLLSHGANIAAVNSDGDLPLDLAE 175



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 25/79 (31%), Positives = 40/79 (50%)

Query: 35  RTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLG 94
           R  +   +ALH A + G+ E++  LLQ G     +D  GW+PLH AA  G ++  + L  
Sbjct: 222 RHPRTGASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAE 281

Query: 95  KGAQVNAVNQNGCTPLHYA 113
            G  ++++   G  P   A
Sbjct: 282 HGGGMDSLTHAGQRPCDLA 300



 Score = 40.0 bits (92), Expect = 0.002
 Identities = 23/65 (35%), Positives = 33/65 (50%)

Query: 73  GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
           G S LH+AA+ G  E+++ LL  G      + +G TPLH AA     +   +L E G   
Sbjct: 227 GASALHVAAAKGYIEVMRLLLQAGYDPELRDGDGWTPLHAAAHWGVEDACRLLAEHGGGM 286

Query: 133 DAKDH 137
           D+  H
Sbjct: 287 DSLTH 291


>gi|157743284 ankyrin repeat domain 52 [Homo sapiens]
          Length = 1076

 Score =  100 bits (249), Expect = 1e-21
 Identities = 64/190 (33%), Positives = 104/190 (54%), Gaps = 1/190 (0%)

Query: 15  YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW 74
           +S  +EE++ S+L+ K      DQ+ RT LH A   G   I++ LL  G  VN KD    
Sbjct: 17  FSRDVEEVR-SLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWL 75

Query: 75  SPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDA 134
           +PLH AA++  ++++  LL   A VNA ++   TPLH AA+    + A  L    ++ + 
Sbjct: 76  TPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNV 135

Query: 135 KDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQ 194
            D    +A+H A   G+L+ +++LL   AS N+ D +   PLH A     +E  KLLV++
Sbjct: 136 ADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVAR 195

Query: 195 GASIYIENKE 204
           GA +  ++++
Sbjct: 196 GADLGCKDRK 205



 Score = 95.9 bits (237), Expect = 2e-20
 Identities = 65/202 (32%), Positives = 102/202 (50%), Gaps = 1/202 (0%)

Query: 12  NLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD 71
           ++A + +  +  E++    S     D+  R+ALH A  +GH E V  LL  G  +N  D 
Sbjct: 112 HVAAANRATKCAEALAPLLSSLNVADRSGRSALHHAVHSGHLETVNLLLNKGASLNVCDK 171

Query: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
               PLH AA  G  E++K L+ +GA +   ++ G   LH AA+  + E+   LL  GA 
Sbjct: 172 KERQPLHWAAFLGHLEVLKLLVARGADLGCKDRKGYGLLHTAAASGQIEVVKYLLRMGAE 231

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC-DEERVEEAKL 190
            D  + +  TA+H A   G   +   L+   A+ N  + +G TPLH+A          +L
Sbjct: 232 IDEPNAFGNTALHIACYLGQDAVAIELVNAGANVNQPNDKGFTPLHVAAVSTNGALCLEL 291

Query: 191 LVSQGASIYIENKEEKTPLQVA 212
           LV+ GA +  ++KE K+PL +A
Sbjct: 292 LVNNGADVNYQSKEGKSPLHMA 313



 Score = 93.2 bits (230), Expect = 2e-19
 Identities = 66/199 (33%), Positives = 100/199 (50%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A + + E++   +LA  +     D+  +T LH A +   T+  E L  L   +N  D +G
Sbjct: 81  AAASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSG 140

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            S LH A  +G  E V  LL KGA +N  ++    PLH+AA     E+  +L+  GA+  
Sbjct: 141 RSALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWAAFLGHLEVLKLLVARGADLG 200

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
            KD      +H AAA G ++++  LL   A  +  +  GNT LH+AC   +   A  LV+
Sbjct: 201 CKDRKGYGLLHTAAASGQIEVVKYLLRMGAEIDEPNAFGNTALHIACYLGQDAVAIELVN 260

Query: 194 QGASIYIENKEEKTPLQVA 212
            GA++   N +  TPL VA
Sbjct: 261 AGANVNQPNDKGFTPLHVA 279



 Score = 92.0 bits (227), Expect = 4e-19
 Identities = 68/239 (28%), Positives = 103/239 (43%), Gaps = 30/239 (12%)

Query: 4   CVSNLMVCNLAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLG 63
           C   L+     YS       E +L+        D   RT LH A S G+ E +  LL  G
Sbjct: 387 CCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSG 446

Query: 64  VPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIA- 122
             +  +D  G +PLH AA+ G  +    L+  GA VN  +  GC+PLHYAA+ + +  A 
Sbjct: 447 ADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506

Query: 123 ---------------------------VMLLEGGANPDAKDHYEATAMHRAAAKGNLKMI 155
                                        LL+ GA+P  +D    TA+H AAA GN + +
Sbjct: 507 PHTPSSHDAEEDEPLKESRRKEAFFCLEFLLDNGADPSLRDRQGYTAVHYAAAYGNRQNL 566

Query: 156 HILL--YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
            +LL   +    +++ T   +PLHLA      E  K L     ++ + + + +T L +A
Sbjct: 567 ELLLEMSFNCLEDVESTIPVSPLHLAAYNGHCEALKTLAETLVNLDVRDHKGRTALFLA 625



 Score = 87.0 bits (214), Expect = 1e-17
 Identities = 66/217 (30%), Positives = 106/217 (48%), Gaps = 8/217 (3%)

Query: 15  YSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW 74
           ++  L  L ++ L+   L    D    + +HWA   GH + +E LL+   P +  +   +
Sbjct: 766 HTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHS-PFSYLEGNPF 824

Query: 75  SPLHIAASAGRDEIVKALLGK-GAQ-VNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP 132
           +PLH A    +D   + LLG  GA+ VN+ +  G TPLH AA  +      MLL+  A  
Sbjct: 825 TPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEV 884

Query: 133 DAKDHYEATAMHRAAAKGNLKMIHILLYY-KASTNIQDTEGNTPLHLACDEERVEEAKLL 191
           +A DH   TA+  AA  G    +  LLY  KA   + D   NT LHLAC +   + A ++
Sbjct: 885 NATDHTGRTALMTAAENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMI 944

Query: 192 VSQGAS---IYIENKEEKTPLQV-AKGGLGLILKRMV 224
           +++      I   N   + PL + A+ GL  +++ ++
Sbjct: 945 LAETQDLGLINATNSALQMPLHIAARNGLASVVQALL 981



 Score = 85.5 bits (210), Expect = 3e-17
 Identities = 56/159 (35%), Positives = 81/159 (50%)

Query: 54  EIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYA 113
           E V  LL     +N  D    +PLH AA  G   I++ LL  GA VNA +    TPLH A
Sbjct: 22  EEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAKDTLWLTPLHRA 81

Query: 114 ASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGN 173
           A+    ++  +LL   A+ +A+D    T +H AAA    K    L    +S N+ D  G 
Sbjct: 82  AASRNEKVLGLLLAHSADVNARDKLWQTPLHVAAANRATKCAEALAPLLSSLNVADRSGR 141

Query: 174 TPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           + LH A     +E   LL+++GAS+ + +K+E+ PL  A
Sbjct: 142 SALHHAVHSGHLETVNLLLNKGASLNVCDKKERQPLHWA 180



 Score = 79.7 bits (195), Expect = 2e-15
 Identities = 59/170 (34%), Positives = 81/170 (47%), Gaps = 5/170 (2%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKD-DA 72
           AY+G  E LK       +L  R D   RTAL  A   G TE VE L   G     K+   
Sbjct: 593 AYNGHCEALKTLAETLVNLDVR-DHKGRTALFLATERGSTECVEVLTAHGASALIKERKR 651

Query: 73  GWSPLHIAASAGRDEIVKALLGKGAQVN---AVNQNGCTPLHYAASKNRHEIAVMLLEGG 129
            W+PLH AA++G  + +  L+  G + +    ++  G TPL  A      +   +LLE G
Sbjct: 652 KWTPLHAAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKG 711

Query: 130 ANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLA 179
           +  DA D    TA+HR A  G    +  LL + A    +D +G TP+HLA
Sbjct: 712 STADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLA 761



 Score = 76.3 bits (186), Expect = 2e-14
 Identities = 56/204 (27%), Positives = 96/204 (47%), Gaps = 10/204 (4%)

Query: 20  EELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDD----AGWS 75
           E+   ++L   +     D   RT +H A + GHT ++  LLQ  +  +  D     +G+S
Sbjct: 734 EDCLAALLDHDAFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYS 793

Query: 76  PLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE--GGANPD 133
           P+H A+  G ++ ++ LL + +  + +  N  TPLH A   N+     MLL   G    +
Sbjct: 794 PMHWASYTGHEDCLELLL-EHSPFSYLEGNPFTPLHCAVINNQDSTTEMLLGALGAKIVN 852

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVS 193
           ++D    T +H AA   N+  + +LL ++A  N  D  G T L  A +  +    + L+ 
Sbjct: 853 SRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLY 912

Query: 194 QG---ASIYIENKEEKTPLQVAKG 214
           +G    ++  ENK     L  +KG
Sbjct: 913 RGKADLTVLDENKNTALHLACSKG 936



 Score = 68.2 bits (165), Expect = 6e-12
 Identities = 52/193 (26%), Positives = 86/193 (44%), Gaps = 18/193 (9%)

Query: 38  QDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGA 97
           ++ ++ LH A   G     + L+Q G  ++  D  G +PLH+AA  G + ++  L+  GA
Sbjct: 304 KEGKSPLHMAAIHGRFTRSQILIQNGSEIDCADKFGNTPLHVAARYGHELLISTLMTNGA 363

Query: 98  QVNAVNQNGCTPLHYA-------------ASKNRHEIAVML-----LEGGANPDAKDHYE 139
                  +   PLH A             +S   + I   L     L  G + +  D+  
Sbjct: 364 DTARRGIHDMFPLHLAVLFGFSDCCRKLLSSGQLYSIVSSLSNEHVLSAGFDINTPDNLG 423

Query: 140 ATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199
            T +H AA+ GN++ +++LL   A    +D  G TPLH A      + A  LV+ GA + 
Sbjct: 424 RTCLHAAASGGNVECLNLLLSSGADLRRRDKFGRTPLHYAAANGSYQCAVTLVTAGAGVN 483

Query: 200 IENKEEKTPLQVA 212
             + +  +PL  A
Sbjct: 484 EADCKGCSPLHYA 496



 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 54/188 (28%), Positives = 89/188 (47%), Gaps = 9/188 (4%)

Query: 28  ADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGW--SPLHIAASAGR 85
           AD SL    D+   TA+H+A + G+ + +E LL++     +  ++    SPLH+AA  G 
Sbjct: 541 ADPSLR---DRQGYTAVHYAAAYGNRQNLELLLEMSFNCLEDVESTIPVSPLHLAAYNGH 597

Query: 86  DEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEA-TAMH 144
            E +K L      ++  +  G T L  A  +   E   +L   GA+   K+     T +H
Sbjct: 598 CEALKTLAETLVNLDVRDHKGRTALFLATERGSTECVEVLTAHGASALIKERKRKWTPLH 657

Query: 145 RAAAKGNLKMIHILL---YYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIE 201
            AAA G+   +H+L+        T++ D  G TPL LA     V+   LL+ +G++    
Sbjct: 658 AAAASGHTDSLHLLIDSGERADITDVMDAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAA 717

Query: 202 NKEEKTPL 209
           +   +T L
Sbjct: 718 DLRGRTAL 725



 Score = 65.1 bits (157), Expect = 5e-11
 Identities = 56/191 (29%), Positives = 81/191 (42%), Gaps = 21/191 (10%)

Query: 42  TALHWAC-SAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100
           T LH A  S      +E L+  G  VN +   G SPLH+AA  GR    + L+  G++++
Sbjct: 274 TPLHVAAVSTNGALCLELLVNNGADVNYQSKEGKSPLHMAAIHGRFTRSQILIQNGSEID 333

Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKG---------- 150
             ++ G TPLH AA      +   L+  GA+   +  ++   +H A   G          
Sbjct: 334 CADKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLS 393

Query: 151 ---------NLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIE 201
                    +L   H+ L      N  D  G T LH A     VE   LL+S GA +   
Sbjct: 394 SGQLYSIVSSLSNEHV-LSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRR 452

Query: 202 NKEEKTPLQVA 212
           +K  +TPL  A
Sbjct: 453 DKFGRTPLHYA 463



 Score = 62.0 bits (149), Expect = 4e-10
 Identities = 47/171 (27%), Positives = 69/171 (40%), Gaps = 18/171 (10%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+   T LH A   GH  ++  L+  G     +      PLH+A   G  +  + LL  G
Sbjct: 336 DKFGNTPLHVAARYGHELLISTLMTNGADTARRGIHDMFPLHLAVLFGFSDCCRKLLSSG 395

Query: 97  A------------------QVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHY 138
                               +N  +  G T LH AAS    E   +LL  GA+   +D +
Sbjct: 396 QLYSIVSSLSNEHVLSAGFDINTPDNLGRTCLHAAASGGNVECLNLLLSSGADLRRRDKF 455

Query: 139 EATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAK 189
             T +H AAA G+ +    L+   A  N  D +G +PLH A   +    A+
Sbjct: 456 GRTPLHYAAANGSYQCAVTLVTAGAGVNEADCKGCSPLHYAAASDTYRRAE 506



 Score = 61.2 bits (147), Expect = 7e-10
 Identities = 49/148 (33%), Positives = 71/148 (47%), Gaps = 5/148 (3%)

Query: 37   DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
            D   RT LH A  A +   +  LLQ    VN  D  G + L  AA  G+   V+ LL +G
Sbjct: 855  DAKGRTPLHAAAFADNVSGLRMLLQHQAEVNATDHTGRTALMTAAENGQTAAVEFLLYRG 914

Query: 97   -AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANP---DAKDHYEATAMHRAAAKGNL 152
             A +  +++N  T LH A SK   + A+M+L    +    +A +      +H AA  G  
Sbjct: 915  KADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGLINATNSALQMPLHIAARNGLA 974

Query: 153  KMIHILLYYKASTNIQDTEGNTPLHLAC 180
             ++  LL + A+    D EG+TP  LAC
Sbjct: 975  SVVQALLSHGATVLAVDEEGHTPA-LAC 1001



 Score = 60.1 bits (144), Expect = 2e-09
 Identities = 48/193 (24%), Positives = 83/193 (43%), Gaps = 7/193 (3%)

Query: 26  ILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGR 85
           +L   S A   D   RTALH     G  + +  LL     V  +D  G +P+H+A++ G 
Sbjct: 707 LLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHDAFVLCRDFKGRTPIHLASACGH 766

Query: 86  DEIVKALLGKGAQVN----AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEAT 141
             +++ LL      +     V+ +G +P+H+A+     +   +LLE       + +   T
Sbjct: 767 TAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHEDCLELLLEHSPFSYLEGN-PFT 825

Query: 142 AMHRAAAKGNLKMIHILLYYKAS--TNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIY 199
            +H A          +LL    +   N +D +G TPLH A   + V   ++L+   A + 
Sbjct: 826 PLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTPLHAAAFADNVSGLRMLLQHQAEVN 885

Query: 200 IENKEEKTPLQVA 212
             +   +T L  A
Sbjct: 886 ATDHTGRTALMTA 898



 Score = 59.3 bits (142), Expect = 3e-09
 Identities = 54/202 (26%), Positives = 90/202 (44%), Gaps = 16/202 (7%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D   +T L  A   GH + V  LL+ G   +  D  G + LH  A  G ++ + ALL   
Sbjct: 685 DAYGQTPLMLAIMNGHVDCVHLLLEKGSTADAADLRGRTALHRGAVTGCEDCLAALLDHD 744

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD----AKDHYEATAMHRAAAKGNL 152
           A V   +  G TP+H A++     +   LL+   + D      D+   + MH A+  G+ 
Sbjct: 745 AFVLCRDFKGRTPIHLASACGHTAVLRTLLQAALSTDPLDAGVDYSGYSPMHWASYTGHE 804

Query: 153 KMIHILLYYKASTNIQDTEGN--TPLHLACDEERVEEAKLLVSQGASIYIENKEEK--TP 208
             + +LL +   + +   EGN  TPLH A    +    ++L+    +  + +++ K  TP
Sbjct: 805 DCLELLLEHSPFSYL---EGNPFTPLHCAVINNQDSTTEMLLGALGAKIVNSRDAKGRTP 861

Query: 209 LQVAK-----GGLGLILKRMVE 225
           L  A       GL ++L+   E
Sbjct: 862 LHAAAFADNVSGLRMLLQHQAE 883



 Score = 58.2 bits (139), Expect = 6e-09
 Identities = 42/118 (35%), Positives = 64/118 (54%), Gaps = 6/118 (5%)

Query: 14   AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLL----QLGVPVNDK 69
            A +G+   ++  +   K+  T  D++  TALH ACS GH +    +L     LG+ +N  
Sbjct: 899  AENGQTAAVEFLLYRGKADLTVLDENKNTALHLACSKGHEKCALMILAETQDLGL-INAT 957

Query: 70   DDAGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTP-LHYAASKNRHEIAVMLL 126
            + A   PLHIAA  G   +V+ALL  GA V AV++ G TP L  A +K+  +   ++L
Sbjct: 958  NSALQMPLHIAARNGLASVVQALLSHGATVLAVDEEGHTPALACAPNKDVADCLALIL 1015



 Score = 47.8 bits (112), Expect = 8e-06
 Identities = 33/104 (31%), Positives = 48/104 (46%)

Query: 109 PLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQ 168
           PL  A      E    LL    N +  D    T +H AA  G++ ++ +LL   A+ N +
Sbjct: 11  PLVQAIFSRDVEEVRSLLSQKENINVLDQERRTPLHAAAYVGDVPILQLLLMSGANVNAK 70

Query: 169 DTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           DT   TPLH A      +   LL++  A +   +K  +TPL VA
Sbjct: 71  DTLWLTPLHRAAASRNEKVLGLLLAHSADVNARDKLWQTPLHVA 114


>gi|34304381 inversin isoform a [Homo sapiens]
          Length = 1065

 Score =  100 bits (248), Expect = 1e-21
 Identities = 61/178 (34%), Positives = 97/178 (54%), Gaps = 2/178 (1%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+   TALH A  +GH   V+ LL+    V+  D    +PL  A   G  ++++ L+  G
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
           A+V+ V+Q+G + LH+AA     ++  +L+E   NP+ +D+   T +  AA  G +  + 
Sbjct: 414 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMA 473

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA-SIYIENKEEK-TPLQVA 212
           +L+   A  NIQD EG T LH +C+   ++  KLL+   A    +EN EE+ TPL  A
Sbjct: 474 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531



 Score = 92.0 bits (227), Expect = 4e-19
 Identities = 61/198 (30%), Positives = 92/198 (46%), Gaps = 2/198 (1%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQL--GVPVNDKDD 71
           A      E  +  L   S+   +D + RT+  WA   G  +++  +L L   + +N  D 
Sbjct: 296 AAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355

Query: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
            G + LH AA +G    VK LL   AQV+A +    TPL  A      ++   L++GGA 
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
            D  D    + +H AA  GN  +  IL+  K + N+QD  G TPL  A     +    +L
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475

Query: 192 VSQGASIYIENKEEKTPL 209
           +   A   I++KE +T L
Sbjct: 476 MENNADPNIQDKEGRTAL 493



 Score = 79.3 bits (194), Expect = 2e-15
 Identities = 56/196 (28%), Positives = 92/196 (46%), Gaps = 4/196 (2%)

Query: 34  TRTDQDSRTALHWACSAGHTEIVEFLLQLGVP-VNDKDDAGWSPLHIAASAGRDEIVKAL 92
           T  D   RT LHWA   GH +IV  LL+         D  G +PLH AA +   E VK  
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308

Query: 93  LGKGAQVNAVNQNGCTPLHYAASKNRHEI--AVMLLEGGANPDAKDHYEATAMHRAAAKG 150
           L   +  +  +  G T   +AA K   ++   ++ L+   + +  D Y  TA+H AA  G
Sbjct: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSG 368

Query: 151 NLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQ 210
           ++  + +LL   A  +  D   +TPL  AC+    +  + L+  GA + + +++  + L 
Sbjct: 369 HVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428

Query: 211 -VAKGGLGLILKRMVE 225
             A GG   + + ++E
Sbjct: 429 WAALGGNADVCQILIE 444



 Score = 77.4 bits (189), Expect = 9e-15
 Identities = 57/185 (30%), Positives = 87/185 (47%), Gaps = 3/185 (1%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG +  +K  +L + +    TD    T L  AC  GH ++++ L++ G  V+  D  G
Sbjct: 365 ALSGHVSTVK-LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            S LH AA  G  ++ + L+      N  +  G TPL  AA         +L+E  A+P+
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT--EGNTPLHLACDEERVEEAKLL 191
            +D    TA+H +   G L  I +LL + A  N  +   E  TPL  A   ER E  + +
Sbjct: 484 IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFM 543

Query: 192 VSQGA 196
           +  GA
Sbjct: 544 LEHGA 548



 Score = 74.3 bits (181), Expect = 8e-14
 Identities = 55/207 (26%), Positives = 93/207 (44%), Gaps = 8/207 (3%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A +G    L+  I+ + +L  + DQ  RT L +   A   +  + LL+ G  VN  D + 
Sbjct: 22  AVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQ 81

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE--GGAN 131
            + LH+AA  G    +K LL + A     +    TPLH        +   +LL+      
Sbjct: 82  RTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGE 141

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC---DEERVEEA 188
            D +D  + TA+H +A   N + + +L+ + ++  I D EG  PLH A    D   V   
Sbjct: 142 VDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTV 201

Query: 189 KLLVSQGAS---IYIENKEEKTPLQVA 212
           + ++    +   +  ++ E +TPL  A
Sbjct: 202 RCILDAAPTESLLNWQDYEGRTPLHFA 228



 Score = 68.2 bits (165), Expect = 6e-12
 Identities = 54/172 (31%), Positives = 77/172 (44%), Gaps = 3/172 (1%)

Query: 44  LHWACSAGHTEIVEFLLQLGVPVNDKDDA-GWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           +H A   G    ++ L+     + DK+D  G +PL     A R +   ALL  GA VN  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
           + +  T LH AA K  +    +LL   AN   KD  E T +H      + K + +LL + 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 163 A--STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A    + QD    T LH +      E  KLL+   ++I I + E K PL  A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA 189



 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 39/105 (37%), Positives = 60/105 (57%), Gaps = 1/105 (0%)

Query: 75  SPLHIAASAG-RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
           S +H AA  G +  + + ++G  A  +  +Q G TPL Y    +R + A  LL+ GA+ +
Sbjct: 16  SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN 75

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178
             DH + TA+H AA KGN + + +LL  +A+   +D E  TPLHL
Sbjct: 76  KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120


>gi|34304379 inversin isoform b [Homo sapiens]
          Length = 895

 Score =  100 bits (248), Expect = 1e-21
 Identities = 61/178 (34%), Positives = 97/178 (54%), Gaps = 2/178 (1%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+   TALH A  +GH   V+ LL+    V+  D    +PL  A   G  ++++ L+  G
Sbjct: 354 DKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGG 413

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
           A+V+ V+Q+G + LH+AA     ++  +L+E   NP+ +D+   T +  AA  G +  + 
Sbjct: 414 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMA 473

Query: 157 ILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGA-SIYIENKEEK-TPLQVA 212
           +L+   A  NIQD EG T LH +C+   ++  KLL+   A    +EN EE+ TPL  A
Sbjct: 474 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYA 531



 Score = 92.0 bits (227), Expect = 4e-19
 Identities = 61/198 (30%), Positives = 92/198 (46%), Gaps = 2/198 (1%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQL--GVPVNDKDD 71
           A      E  +  L   S+   +D + RT+  WA   G  +++  +L L   + +N  D 
Sbjct: 296 AAQSNFAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADK 355

Query: 72  AGWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGAN 131
            G + LH AA +G    VK LL   AQV+A +    TPL  A      ++   L++GGA 
Sbjct: 356 YGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGAR 415

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLL 191
            D  D    + +H AA  GN  +  IL+  K + N+QD  G TPL  A     +    +L
Sbjct: 416 VDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 475

Query: 192 VSQGASIYIENKEEKTPL 209
           +   A   I++KE +T L
Sbjct: 476 MENNADPNIQDKEGRTAL 493



 Score = 79.3 bits (194), Expect = 2e-15
 Identities = 56/196 (28%), Positives = 92/196 (46%), Gaps = 4/196 (2%)

Query: 34  TRTDQDSRTALHWACSAGHTEIVEFLLQLGVP-VNDKDDAGWSPLHIAASAGRDEIVKAL 92
           T  D   RT LHWA   GH +IV  LL+         D  G +PLH AA +   E VK  
Sbjct: 249 TSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVF 308

Query: 93  LGKGAQVNAVNQNGCTPLHYAASKNRHEI--AVMLLEGGANPDAKDHYEATAMHRAAAKG 150
           L   +  +  +  G T   +AA K   ++   ++ L+   + +  D Y  TA+H AA  G
Sbjct: 309 LKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTALHAAALSG 368

Query: 151 NLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQ 210
           ++  + +LL   A  +  D   +TPL  AC+    +  + L+  GA + + +++  + L 
Sbjct: 369 HVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDGHSLLH 428

Query: 211 -VAKGGLGLILKRMVE 225
             A GG   + + ++E
Sbjct: 429 WAALGGNADVCQILIE 444



 Score = 77.4 bits (189), Expect = 9e-15
 Identities = 57/185 (30%), Positives = 87/185 (47%), Gaps = 3/185 (1%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A SG +  +K  +L + +    TD    T L  AC  GH ++++ L++ G  V+  D  G
Sbjct: 365 ALSGHVSTVK-LLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVDQDG 423

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
            S LH AA  G  ++ + L+      N  +  G TPL  AA         +L+E  A+P+
Sbjct: 424 HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPN 483

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDT--EGNTPLHLACDEERVEEAKLL 191
            +D    TA+H +   G L  I +LL + A  N  +   E  TPL  A   ER E  + +
Sbjct: 484 IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVIQFM 543

Query: 192 VSQGA 196
           +  GA
Sbjct: 544 LEHGA 548



 Score = 74.3 bits (181), Expect = 8e-14
 Identities = 55/207 (26%), Positives = 93/207 (44%), Gaps = 8/207 (3%)

Query: 14  AYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAG 73
           A +G    L+  I+ + +L  + DQ  RT L +   A   +  + LL+ G  VN  D + 
Sbjct: 22  AVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKTDHSQ 81

Query: 74  WSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE--GGAN 131
            + LH+AA  G    +K LL + A     +    TPLH        +   +LL+      
Sbjct: 82  RTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFMAPGE 141

Query: 132 PDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLAC---DEERVEEA 188
            D +D  + TA+H +A   N + + +L+ + ++  I D EG  PLH A    D   V   
Sbjct: 142 VDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTV 201

Query: 189 KLLVSQGAS---IYIENKEEKTPLQVA 212
           + ++    +   +  ++ E +TPL  A
Sbjct: 202 RCILDAAPTESLLNWQDYEGRTPLHFA 228



 Score = 68.2 bits (165), Expect = 6e-12
 Identities = 54/172 (31%), Positives = 77/172 (44%), Gaps = 3/172 (1%)

Query: 44  LHWACSAGHTEIVEFLLQLGVPVNDKDDA-GWSPLHIAASAGRDEIVKALLGKGAQVNAV 102
           +H A   G    ++ L+     + DK+D  G +PL     A R +   ALL  GA VN  
Sbjct: 18  VHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVNKT 77

Query: 103 NQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYK 162
           + +  T LH AA K  +    +LL   AN   KD  E T +H      + K + +LL + 
Sbjct: 78  DHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHLTTRHRSPKCLALLLKFM 137

Query: 163 A--STNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           A    + QD    T LH +      E  KLL+   ++I I + E K PL  A
Sbjct: 138 APGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDVEGKIPLHWA 189



 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 39/105 (37%), Positives = 60/105 (57%), Gaps = 1/105 (0%)

Query: 75  SPLHIAASAG-RDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPD 133
           S +H AA  G +  + + ++G  A  +  +Q G TPL Y    +R + A  LL+ GA+ +
Sbjct: 16  SQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADRLDCADALLKAGADVN 75

Query: 134 AKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHL 178
             DH + TA+H AA KGN + + +LL  +A+   +D E  TPLHL
Sbjct: 76  KTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL 120


>gi|30348954 mindbomb homolog 1 [Homo sapiens]
          Length = 1006

 Score = 99.4 bits (246), Expect = 2e-21
 Identities = 62/176 (35%), Positives = 94/176 (53%), Gaps = 4/176 (2%)

Query: 41  RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100
           +T LH A + GH ++V+ LL  G   + +D  G +PLH A S  RD+I+  LL  GA V 
Sbjct: 531 QTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVT 590

Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANP---DAKDHYEATAMHRAAAKGNLKMIHI 157
             N NG   LH+AA +       +LL     P   D K     TA+H AA   ++++  +
Sbjct: 591 ITNNNGFNALHHAALRGNPSAMRVLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAEL 650

Query: 158 LLYY-KASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
           L++   A+ +IQ+    T LHLA + +  +  +LLV  GA + I++K+  TPL  A
Sbjct: 651 LVHQGNANLDIQNVNQQTALHLAVERQHTQIVRLLVRAGAKLDIQDKDGDTPLHEA 706



 Score = 97.4 bits (241), Expect = 9e-21
 Identities = 64/180 (35%), Positives = 95/180 (52%), Gaps = 4/180 (2%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           D+D   A+H A       ++E L +    +N ++    +PLHIA + G  ++VK LL  G
Sbjct: 494 DKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPLHIAVNKGHLQVVKTLLDFG 553

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIH 156
              +  +  G TPLH A SK R +I  +LLE GA+    ++    A+H AA +GN   + 
Sbjct: 554 CHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITNNNGFNALHHAALRGNPSAMR 613

Query: 157 ILLYYKASTNIQD---TEGNTPLHLACDEERVEEAKLLVSQG-ASIYIENKEEKTPLQVA 212
           +LL       I D    +G T LHLA     VE A+LLV QG A++ I+N  ++T L +A
Sbjct: 614 VLLSKLPRPWIVDEKKDDGYTALHLAALNNHVEVAELLVHQGNANLDIQNVNQQTALHLA 673



 Score = 78.6 bits (192), Expect = 4e-15
 Identities = 56/179 (31%), Positives = 94/179 (52%), Gaps = 2/179 (1%)

Query: 25  SILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQL-GVPVNDKDDAGWSPLHIAASA 83
           S L  K   T+   D    L  A + G    VE LL+   V VN +  AG + +  A+  
Sbjct: 416 SQLLKKLFETQESGDLNEELVKAAANGDVAKVEDLLKRPDVDVNGQC-AGHTAMQAASQN 474

Query: 84  GRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAM 143
           G  +I+K LL +   V A +++G   +H+AA  +   +  +L  G A+ +A++    T +
Sbjct: 475 GHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKRRQTPL 534

Query: 144 HRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIEN 202
           H A  KG+L+++  LL +    ++QD+EG+TPLH A  ++R +   +L+  GA + I N
Sbjct: 535 HIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDAISKKRDDILAVLLEAGADVTITN 593



 Score = 47.0 bits (110), Expect = 1e-05
 Identities = 31/101 (30%), Positives = 52/101 (51%), Gaps = 1/101 (0%)

Query: 113 AASKNRH-EIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLYYKASTNIQDTE 171
           AAS+N H +I  +LL+   + +A+D     A+H AA      +I +L    A  N ++  
Sbjct: 470 AASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNARNKR 529

Query: 172 GNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQVA 212
             TPLH+A ++  ++  K L+  G    +++ E  TPL  A
Sbjct: 530 RQTPLHIAVNKGHLQVVKTLLDFGCHPSLQDSEGDTPLHDA 570



 Score = 37.7 bits (86), Expect = 0.008
 Identities = 22/81 (27%), Positives = 40/81 (49%), Gaps = 2/81 (2%)

Query: 141 TAMHRAAAKGNLKMIHILLYYKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYI 200
           TAM  A+  G++ ++ +LL        +D +G+  +H A   +     ++L    A +  
Sbjct: 466 TAMQAASQNGHVDILKLLLKQNVDVEAEDKDGDRAVHHAAFGDEGAVIEVLHRGSADLNA 525

Query: 201 ENKEEKTPLQVA--KGGLGLI 219
            NK  +TPL +A  KG L ++
Sbjct: 526 RNKRRQTPLHIAVNKGHLQVV 546


>gi|116875852 HECT domain and ankyrin repeat containing, E3
           ubiquitin protein ligase 1 [Homo sapiens]
          Length = 909

 Score = 97.8 bits (242), Expect = 7e-21
 Identities = 60/178 (33%), Positives = 94/178 (52%), Gaps = 2/178 (1%)

Query: 41  RTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKGAQVN 100
           R+ LH A + G  E +  LL+ G   N +D +G +PLH+AA  G+ + +  LL   A VN
Sbjct: 66  RSLLHIAANCGSVECLVLLLKKGANPNYQDISGCTPLHLAARNGQKKCMSKLLEYSADVN 125

Query: 101 AVNQNGCTPLHYAASKNRHEIAVMLLEGGANPDAKDHYEATAMHRAAAKGNLKMIHILLY 160
             N  G T +H+ A   R E+   L++  ++ D +D    TA+H A   G+   +  LL 
Sbjct: 126 ICNNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLD 185

Query: 161 YKASTNIQDTEGNTPLHLACDEERVEEAKLLVSQGASIYIENKEEKTPLQV-AKGGLG 217
             A  N  +  G TPL+ AC   + + A++L+ +GA  Y+ +K   TPL +  +GG G
Sbjct: 186 SGADINRPNVSGATPLYFACSHGQRDTAQILLLRGAK-YLPDKNGVTPLDLCVQGGYG 242



 Score = 65.5 bits (158), Expect = 4e-11
 Identities = 34/94 (36%), Positives = 52/94 (55%)

Query: 37  DQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDAGWSPLHIAASAGRDEIVKALLGKG 96
           + +  TA+HW    G TE++  L+Q    V+ +D  G + LH+A   G    V+ LL  G
Sbjct: 128 NNEGLTAIHWLAVNGRTELLHDLVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSG 187

Query: 97  AQVNAVNQNGCTPLHYAASKNRHEIAVMLLEGGA 130
           A +N  N +G TPL++A S  + + A +LL  GA
Sbjct: 188 ADINRPNVSGATPLYFACSHGQRDTAQILLLRGA 221



 Score = 54.3 bits (129), Expect = 8e-08
 Identities = 37/115 (32%), Positives = 59/115 (51%), Gaps = 2/115 (1%)

Query: 13  LAYSGKLEELKESILADKSLATRTDQDSRTALHWACSAGHTEIVEFLLQLGVPVNDKDDA 72
           LA +G+ E L + ++   S     D   +TALH AC  GH   V+ LL  G  +N  + +
Sbjct: 138 LAVNGRTELLHD-LVQHVSDVDVEDAMGQTALHVACQNGHKTTVQCLLDSGADINRPNVS 196

Query: 73  GWSPLHIAASAGRDEIVKALLGKGAQVNAVNQNGCTPLHYAASKNRHEIAVMLLE 127
           G +PL+ A S G+ +  + LL +GA+    ++NG TPL         E   +L++
Sbjct: 197 GATPLYFACSHGQRDTAQILLLRGAKY-LPDKNGVTPLDLCVQGGYGETCEVLIQ 250


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 8,150,794
Number of Sequences: 37866
Number of extensions: 332303
Number of successful extensions: 4300
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 359
Number of HSP's successfully gapped in prelim test: 37
Number of HSP's that attempted gapping in prelim test: 591
Number of HSP's gapped (non-prelim): 2017
length of query: 226
length of database: 18,247,518
effective HSP length: 99
effective length of query: 127
effective length of database: 14,498,784
effective search space: 1841345568
effective search space used: 1841345568
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 60 (27.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.