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Search of human proteins with 4506013
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
sapiens]
(360 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo sap... 697 0.0
gi|55743114 leucine rich repeat containing 49 [Homo sapiens] 116 4e-26
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 94 2e-19
gi|194272228 leucine rich repeat containing 48 isoform b [Homo s... 92 6e-19
gi|194272226 leucine rich repeat containing 48 isoform b [Homo s... 92 6e-19
gi|194272224 leucine rich repeat containing 48 isoform a [Homo s... 92 6e-19
gi|194272222 leucine rich repeat containing 48 isoform a [Homo s... 92 6e-19
gi|157674358 leucine rich repeat containing 50 [Homo sapiens] 88 1e-17
gi|206725447 leucine rich repeat containing 23 isoform a [Homo s... 87 2e-17
gi|42542396 leucine rich repeat containing 23 isoform a [Homo sa... 87 2e-17
gi|117414162 sodium channel associated protein 2 isoform a [Homo... 86 5e-17
gi|31377705 centrosomal protein 97kDa [Homo sapiens] 83 3e-16
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 82 7e-16
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 81 2e-15
gi|197333692 leucine rich repeat containing 8 family, member B [... 80 3e-15
gi|21245134 leucine rich repeat containing 8 family, member B [H... 80 3e-15
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 77 2e-14
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 77 2e-14
gi|61966709 leucine rich repeat containing 67 [Homo sapiens] 77 3e-14
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 76 4e-14
gi|19923729 leucine rich repeat containing 8 family, member C [H... 74 2e-13
gi|62241040 leucine rich repeat containing 8 family, member A [H... 74 3e-13
gi|187829877 leucine rich repeat containing 8 family, member A [... 74 3e-13
gi|187829871 leucine rich repeat containing 8 family, member A [... 74 3e-13
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 73 5e-13
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 72 6e-13
gi|239752518 PREDICTED: similar to leucine rich repeat containin... 71 1e-12
gi|51317373 netrin-G1 ligand [Homo sapiens] 71 1e-12
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 70 2e-12
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 70 3e-12
>gi|4506013 protein phosphatase 1, regulatory subunit 7 [Homo
sapiens]
Length = 360
Score = 697 bits (1800), Expect = 0.0
Identities = 360/360 (100%), Positives = 360/360 (100%)
Query: 1 MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE 60
MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE
Sbjct: 1 MAAERGAGQQQSQEMMEVDRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGEEDPE 60
Query: 61 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ 120
EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ
Sbjct: 61 EEHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQ 120
Query: 121 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 180
SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE
Sbjct: 121 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 180
Query: 181 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 240
NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN
Sbjct: 181 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 240
Query: 241 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300
RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE
Sbjct: 241 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300
Query: 301 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF 360
FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF
Sbjct: 301 FWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATFVRF 360
>gi|55743114 leucine rich repeat containing 49 [Homo sapiens]
Length = 686
Score = 116 bits (290), Expect = 4e-26
Identities = 63/189 (33%), Positives = 111/189 (58%)
Query: 166 LKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQN 225
L+ L +N I++I+N+SNL +L L+L N+I I + TL L L LGKN+I K+ N
Sbjct: 114 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISN 173
Query: 226 LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNR 285
L+ L +L VL + N++TKIE + +L LR L L+ N + ++ L + LT L++ N+
Sbjct: 174 LENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQ 233
Query: 286 IKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVML 345
I + ++ +L LQ +++ N + S+ + L + SL + + NP+ ++ Y+ V+
Sbjct: 234 ITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQ 293
Query: 346 ALPSVRQID 354
+ +RQ+D
Sbjct: 294 NMMQLRQLD 302
Score = 102 bits (255), Expect = 4e-22
Identities = 77/241 (31%), Positives = 123/241 (51%), Gaps = 17/241 (7%)
Query: 106 RQNLIKC-IENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLT 164
RQ L C I N E+ LR L+ N I +I+N+ L +L LD+ N + I G+ L
Sbjct: 99 RQKLTVCPIINGED--HLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLR 156
Query: 165 RLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQ 224
L+ L L N+I KI NL NL L +L+L N+I IENI+ L L L L +N ++ +
Sbjct: 157 CLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVD 216
Query: 225 NLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGI---EVIEGLENNNKLTMLDI 281
NL+ L +LT L+++ N++T + + NL L+ L+LS N I + + L +++ L+ +
Sbjct: 217 NLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITF 276
Query: 282 ASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRR 341
N I QE W +L++ L +L R E + L K + ++
Sbjct: 277 DGNPI-----------AQESWYKHTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKK 325
Query: 342 K 342
+
Sbjct: 326 R 326
Score = 95.1 bits (235), Expect = 9e-20
Identities = 63/185 (34%), Positives = 101/185 (54%), Gaps = 8/185 (4%)
Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
++ H I +I+ L+K+ +L L N I+ I L L+ LR L L N+IKKI NLE
Sbjct: 117 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLEN 176
Query: 141 LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRA 200
L L++LD+ N + IE ++ L L+ L L N +S ++NL+ L L L L N+I
Sbjct: 177 LKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITF 236
Query: 201 IENIDTLTNLESLFLGKNKITKLQNLDAL---TNLTVLSMQSNRLT-----KIEGLQNLV 252
+ ++D L L+ LFL N I+ ++ L ++L+ ++ N + K LQN++
Sbjct: 237 VRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMM 296
Query: 253 NLREL 257
LR+L
Sbjct: 297 QLRQL 301
Score = 90.5 bits (223), Expect = 2e-18
Identities = 71/241 (29%), Positives = 122/241 (50%), Gaps = 14/241 (5%)
Query: 62 EHELPVDMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQS 121
+H ++ I+ + +DL +I +I G L+ ++ L L +N IK I NLE L+S
Sbjct: 120 QHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKS 179
Query: 122 LRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN 181
L LDL+ NQI KIEN+ L EL +L+++ N L +++ ++ L L +L L +N+I+ + +
Sbjct: 180 LDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD 239
Query: 182 LSNLHQLQMLELGSNRIRAIENIDTLTNLESL----FLGK-------NKITKLQNLDALT 230
+ NL LQ L L N I + +++ L + SL F G K T LQN+ L
Sbjct: 240 VDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLR 299
Query: 231 NLTV--LSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKK 288
L + ++ + R+ + + RE + + ++ + L NN D+ R+
Sbjct: 300 QLDMKRITEEERRMASVLAKKEEEKKRESH-KQSLLKEKKRLTINNVARQWDLQQQRVAN 358
Query: 289 I 289
I
Sbjct: 359 I 359
Score = 48.1 bits (113), Expect = 1e-05
Identities = 37/127 (29%), Positives = 62/127 (48%), Gaps = 3/127 (2%)
Query: 209 NLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIE 268
NL S L I + + + + LS++ +LT + +LR L HN I I+
Sbjct: 69 NLVSSSLSSFPILQRSSEEKILYSDRLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQ 128
Query: 269 GLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYL 328
+ N KL LD+ N+I++I +S L L+ + N ++ S+L+ LK SL+ + L
Sbjct: 129 NISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLK---SLDVLDL 185
Query: 329 ERNPLQK 335
N + K
Sbjct: 186 HGNQITK 192
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 94.0 bits (232), Expect = 2e-19
Identities = 68/233 (29%), Positives = 114/233 (48%), Gaps = 23/233 (9%)
Query: 122 LRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN 181
L++LDL N+I+ + + + L L+ S N L LKK +N+IS+I +
Sbjct: 151 LQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEICD 210
Query: 182 LSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNR 241
LS H L L L N I I ++ NL L L NKIT + L+ L + +L + +N+
Sbjct: 211 LSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKLP-IKILCLSNNQ 269
Query: 242 LTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEF 301
+ I GL++L L+ L LSHN I ++GLEN++ L ++++ N+I ++ I +
Sbjct: 270 IEMITGLEDLKALQNLDLSHNQISSLQGLENHDLLEVINLEDNKIAELREIEY------- 322
Query: 302 WMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 354
+K L + L NP+Q+ +Y V+ L + ++D
Sbjct: 323 ---------------IKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD 360
Score = 56.2 bits (134), Expect = 4e-08
Identities = 43/137 (31%), Positives = 69/137 (50%), Gaps = 7/137 (5%)
Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
+ L + +I I G L +K LCL N I+ I LE+L++L+ LDL NQI ++ LE
Sbjct: 242 LSLANNKITTINGLNKLP-IKILCLSNNQIEMITGLEDLKALQNLDLSHNQISSLQGLEN 300
Query: 141 LTELEILDISFNL---LRNIEGVDKLTRLKKLFLVNNKI---SKIENLSNLHQLQMLELG 194
LE++++ N LR IE + L L+ L L+ N I S+ L++ EL
Sbjct: 301 HDLLEVINLEDNKIAELREIEYIKNLPILRVLNLLENPIQEKSEYWFFVIFMLLRLTELD 360
Query: 195 SNRIRAIENIDTLTNLE 211
+I+ E + + +
Sbjct: 361 QKKIKVEEKVSAVNKYD 377
Score = 47.0 bits (110), Expect = 3e-05
Identities = 39/148 (26%), Positives = 67/148 (45%), Gaps = 23/148 (15%)
Query: 209 NLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSH------- 261
+L+ L L NKI L + + L L+ N LT + NL++ SH
Sbjct: 150 HLQKLDLSANKIEDLSCVSCMPYLLELNASQNNLTTFFNFKPPKNLKKADFSHNQISEIC 209
Query: 262 ---------------NGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDN 306
N IE I GLE N L L +A+N+I I ++ L ++ +++N
Sbjct: 210 DLSAYHALTKLILDGNEIEEISGLEMCNNLIHLSLANNKITTINGLNKL-PIKILCLSNN 268
Query: 307 LLESWSDLDELKGARSLETVYLERNPLQ 334
+E + L++LK ++L+ + + + LQ
Sbjct: 269 QIEMITGLEDLKALQNLDLSHNQISSLQ 296
>gi|194272228 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 92.4 bits (228), Expect = 6e-19
Identities = 61/142 (42%), Positives = 89/142 (62%), Gaps = 4/142 (2%)
Query: 87 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEI 146
++ K EG + K V +L L I I+NL + ++LR+L L +N I+KIE LE L L
Sbjct: 33 QLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVW 91
Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206
LD+SFN + IEG+D L L+ L L NN+ISKI++L L +LQ+L LG+NRI + NI
Sbjct: 92 LDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIY 151
Query: 207 LTN---LESLFLGKNKITKLQN 225
L L +L L +N I++ ++
Sbjct: 152 LRRFKCLRTLSLSRNPISEAED 173
Score = 88.2 bits (217), Expect = 1e-17
Identities = 68/202 (33%), Positives = 100/202 (49%), Gaps = 18/202 (8%)
Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206
L + F + I+ + + L+KL L NN I KIE L NL L L+L N I IE +DT
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRE------LYLS 260
L NLE L L N+I+K+ +LDAL L VLS+ +NR I+ + N++ LR L LS
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNR---IDNMMNIIYLRRFKCLRTLSLS 164
Query: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGA 320
N I E + + D+ ++I++ H +L E + +DELK
Sbjct: 165 RNPISEAEDYKMFICAYLPDLMYLDYRRIDD--HTKKLAE-------AKHQYSIDELKHQ 215
Query: 321 RSLETVYLERNPLQKDPQYRRK 342
+L LE Q++ + K
Sbjct: 216 ENLMQAQLEDEQAQREELEKHK 237
Score = 85.9 bits (211), Expect = 5e-17
Identities = 50/143 (34%), Positives = 80/143 (55%)
Query: 212 SLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLE 271
SL L I ++ NL NL L + +N + KIEGL+NL +L L LS N IE IEGL+
Sbjct: 47 SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLD 106
Query: 272 NNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 331
L L + +NRI KI+++ L +LQ + +N +++ ++ L+ + L T+ L RN
Sbjct: 107 TLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRN 166
Query: 332 PLQKDPQYRRKVMLALPSVRQID 354
P+ + Y+ + LP + +D
Sbjct: 167 PISEAEDYKMFICAYLPDLMYLD 189
>gi|194272226 leucine rich repeat containing 48 isoform b [Homo
sapiens]
Length = 457
Score = 92.4 bits (228), Expect = 6e-19
Identities = 61/142 (42%), Positives = 89/142 (62%), Gaps = 4/142 (2%)
Query: 87 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEI 146
++ K EG + K V +L L I I+NL + ++LR+L L +N I+KIE LE L L
Sbjct: 33 QLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVW 91
Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206
LD+SFN + IEG+D L L+ L L NN+ISKI++L L +LQ+L LG+NRI + NI
Sbjct: 92 LDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIY 151
Query: 207 LTN---LESLFLGKNKITKLQN 225
L L +L L +N I++ ++
Sbjct: 152 LRRFKCLRTLSLSRNPISEAED 173
Score = 88.2 bits (217), Expect = 1e-17
Identities = 68/202 (33%), Positives = 100/202 (49%), Gaps = 18/202 (8%)
Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206
L + F + I+ + + L+KL L NN I KIE L NL L L+L N I IE +DT
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRE------LYLS 260
L NLE L L N+I+K+ +LDAL L VLS+ +NR I+ + N++ LR L LS
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNR---IDNMMNIIYLRRFKCLRTLSLS 164
Query: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGA 320
N I E + + D+ ++I++ H +L E + +DELK
Sbjct: 165 RNPISEAEDYKMFICAYLPDLMYLDYRRIDD--HTKKLAE-------AKHQYSIDELKHQ 215
Query: 321 RSLETVYLERNPLQKDPQYRRK 342
+L LE Q++ + K
Sbjct: 216 ENLMQAQLEDEQAQREELEKHK 237
Score = 85.9 bits (211), Expect = 5e-17
Identities = 50/143 (34%), Positives = 80/143 (55%)
Query: 212 SLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLE 271
SL L I ++ NL NL L + +N + KIEGL+NL +L L LS N IE IEGL+
Sbjct: 47 SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLD 106
Query: 272 NNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 331
L L + +NRI KI+++ L +LQ + +N +++ ++ L+ + L T+ L RN
Sbjct: 107 TLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRN 166
Query: 332 PLQKDPQYRRKVMLALPSVRQID 354
P+ + Y+ + LP + +D
Sbjct: 167 PISEAEDYKMFICAYLPDLMYLD 189
>gi|194272224 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 92.4 bits (228), Expect = 6e-19
Identities = 61/142 (42%), Positives = 89/142 (62%), Gaps = 4/142 (2%)
Query: 87 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEI 146
++ K EG + K V +L L I I+NL + ++LR+L L +N I+KIE LE L L
Sbjct: 33 QLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVW 91
Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206
LD+SFN + IEG+D L L+ L L NN+ISKI++L L +LQ+L LG+NRI + NI
Sbjct: 92 LDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIY 151
Query: 207 LTN---LESLFLGKNKITKLQN 225
L L +L L +N I++ ++
Sbjct: 152 LRRFKCLRTLSLSRNPISEAED 173
Score = 88.2 bits (217), Expect = 1e-17
Identities = 68/202 (33%), Positives = 100/202 (49%), Gaps = 18/202 (8%)
Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206
L + F + I+ + + L+KL L NN I KIE L NL L L+L N I IE +DT
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRE------LYLS 260
L NLE L L N+I+K+ +LDAL L VLS+ +NR I+ + N++ LR L LS
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNR---IDNMMNIIYLRRFKCLRTLSLS 164
Query: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGA 320
N I E + + D+ ++I++ H +L E + +DELK
Sbjct: 165 RNPISEAEDYKMFICAYLPDLMYLDYRRIDD--HTKKLAE-------AKHQYSIDELKHQ 215
Query: 321 RSLETVYLERNPLQKDPQYRRK 342
+L LE Q++ + K
Sbjct: 216 ENLMQAQLEDEQAQREELEKHK 237
Score = 85.9 bits (211), Expect = 5e-17
Identities = 50/143 (34%), Positives = 80/143 (55%)
Query: 212 SLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLE 271
SL L I ++ NL NL L + +N + KIEGL+NL +L L LS N IE IEGL+
Sbjct: 47 SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLD 106
Query: 272 NNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 331
L L + +NRI KI+++ L +LQ + +N +++ ++ L+ + L T+ L RN
Sbjct: 107 TLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRN 166
Query: 332 PLQKDPQYRRKVMLALPSVRQID 354
P+ + Y+ + LP + +D
Sbjct: 167 PISEAEDYKMFICAYLPDLMYLD 189
>gi|194272222 leucine rich repeat containing 48 isoform a [Homo
sapiens]
Length = 523
Score = 92.4 bits (228), Expect = 6e-19
Identities = 61/142 (42%), Positives = 89/142 (62%), Gaps = 4/142 (2%)
Query: 87 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEI 146
++ K EG + K V +L L I I+NL + ++LR+L L +N I+KIE LE L L
Sbjct: 33 QLAKQEGI-LFKDVLSLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVW 91
Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206
LD+SFN + IEG+D L L+ L L NN+ISKI++L L +LQ+L LG+NRI + NI
Sbjct: 92 LDLSFNNIETIEGLDTLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIY 151
Query: 207 LTN---LESLFLGKNKITKLQN 225
L L +L L +N I++ ++
Sbjct: 152 LRRFKCLRTLSLSRNPISEAED 173
Score = 88.2 bits (217), Expect = 1e-17
Identities = 68/202 (33%), Positives = 100/202 (49%), Gaps = 18/202 (8%)
Query: 147 LDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDT 206
L + F + I+ + + L+KL L NN I KIE L NL L L+L N I IE +DT
Sbjct: 48 LQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLDT 107
Query: 207 LTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRE------LYLS 260
L NLE L L N+I+K+ +LDAL L VLS+ +NR I+ + N++ LR L LS
Sbjct: 108 LVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNR---IDNMMNIIYLRRFKCLRTLSLS 164
Query: 261 HNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGA 320
N I E + + D+ ++I++ H +L E + +DELK
Sbjct: 165 RNPISEAEDYKMFICAYLPDLMYLDYRRIDD--HTKKLAE-------AKHQYSIDELKHQ 215
Query: 321 RSLETVYLERNPLQKDPQYRRK 342
+L LE Q++ + K
Sbjct: 216 ENLMQAQLEDEQAQREELEKHK 237
Score = 85.9 bits (211), Expect = 5e-17
Identities = 50/143 (34%), Positives = 80/143 (55%)
Query: 212 SLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLE 271
SL L I ++ NL NL L + +N + KIEGL+NL +L L LS N IE IEGL+
Sbjct: 47 SLQLDFRNILRIDNLWQFENLRKLQLDNNIIEKIEGLENLAHLVWLDLSFNNIETIEGLD 106
Query: 272 NNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 331
L L + +NRI KI+++ L +LQ + +N +++ ++ L+ + L T+ L RN
Sbjct: 107 TLVNLEDLSLFNNRISKIDSLDALVKLQVLSLGNNRIDNMMNIIYLRRFKCLRTLSLSRN 166
Query: 332 PLQKDPQYRRKVMLALPSVRQID 354
P+ + Y+ + LP + +D
Sbjct: 167 PISEAEDYKMFICAYLPDLMYLD 189
>gi|157674358 leucine rich repeat containing 50 [Homo sapiens]
Length = 725
Score = 88.2 bits (217), Expect = 1e-17
Identities = 63/156 (40%), Positives = 88/156 (56%), Gaps = 7/156 (4%)
Query: 113 IENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLV 172
IENLEE LR L L N I+KIENLEA TEL L + NLLR IE ++ L +L L L
Sbjct: 122 IENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLS 181
Query: 173 NNKISKIENLSNLHQLQMLELGSNRIRAIENIDTL---TNLESLFLGKNKITK---LQNL 226
NN I IENLS L L L++ N + +E+I L L L L NK++ L L
Sbjct: 182 NNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNKLSDPEILSIL 241
Query: 227 DALTNLTVLSMQSNR-LTKIEGLQNLVNLRELYLSH 261
+++ +L VL++ N + +I + V +R +L++
Sbjct: 242 ESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTY 277
Score = 83.6 bits (205), Expect = 3e-16
Identities = 64/189 (33%), Positives = 92/189 (48%), Gaps = 11/189 (5%)
Query: 177 SKIENLSNLHQLQM-------LELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDAL 229
S ++ L H+L + L L IEN++ T L L+L N I K++NL+A
Sbjct: 91 SSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQ 150
Query: 230 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKI 289
T L L +Q N L KIE L+ L L L LS+N I+ IE L L L +A N ++ +
Sbjct: 151 TELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETV 210
Query: 290 ENISHLTELQEFWMND---NLLESWSDLDELKGARSLETVYLERNP-LQKDPQYRRKVML 345
E+I HL E + D N L L L+ L + L NP +++ P YRR V +
Sbjct: 211 EDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTV 270
Query: 346 ALPSVRQID 354
L + +D
Sbjct: 271 RLKHLTYLD 279
Score = 78.6 bits (192), Expect = 8e-15
Identities = 59/171 (34%), Positives = 91/171 (53%), Gaps = 15/171 (8%)
Query: 145 EILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENI 204
+ L + F IE +++ T L+ L+L +N I KIENL +L+ L L N +R IEN+
Sbjct: 110 DTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENL 169
Query: 205 DTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNL---VNLRELYLSH 261
+ L L++L L N I ++NL L L L M N L +E +Q+L + L L LSH
Sbjct: 170 EPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSH 229
Query: 262 NGI---EVIEGLENNNKLTMLDIASNR-IKKIEN--------ISHLTELQE 300
N + E++ LE+ L +L++ N I++I N + HLT L +
Sbjct: 230 NKLSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTVRLKHLTYLDD 280
Score = 73.9 bits (180), Expect = 2e-13
Identities = 57/192 (29%), Positives = 96/192 (50%), Gaps = 12/192 (6%)
Query: 125 LDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSN 184
L L+ +IENLE T L L + N ++ IE ++ T L+ LFL N + KIENL
Sbjct: 112 LYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIENLEAQTELRCLFLQMNLLRKIENLEP 171
Query: 185 LHQLQMLELGSNRIRAIENIDTLTNLESLFLGKN---KITKLQNLDALTNLTVLSMQSNR 241
L +L L L +N I+ IEN+ L L +L + N + +Q+L L VL + N+
Sbjct: 172 LQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNHLETVEDIQHLQECLRLCVLDLSHNK 231
Query: 242 LTKIEGLQNLVNLREL-YLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300
L+ E L L ++ +L L+ G VI + N + + +++++++L +
Sbjct: 232 LSDPEILSILESMPDLRVLNLMGNPVIRQIPNYRRTVTV--------RLKHLTYLDDRPV 283
Query: 301 FWMNDNLLESWS 312
F + E+W+
Sbjct: 284 FPKDRACAEAWA 295
Score = 69.3 bits (168), Expect = 5e-12
Identities = 60/221 (27%), Positives = 105/221 (47%), Gaps = 15/221 (6%)
Query: 2 AAERGAGQQQSQEMMEV-----DRRVESEESGDEEGKKHSSGIVADLSEQSLKDGEERGE 56
+A RG +++ + E+ D S++ + G S G A E D E+RG
Sbjct: 33 SAGRGGCKEEINDPKEICVGSSDTSYHSQQK--QSGDNGSGGHFAHPRE----DREDRGP 86
Query: 57 EDPEEEHELPVDMETINLDRDAEDVDLNHYR-IGKIEGFEVLKKVKTLCLRQNLIKCIEN 115
+ + + + D H++ +IE E ++ L L+ N I+ IEN
Sbjct: 87 RMTKSSLQKLCKQHKLYITPALNDTLYLHFKGFDRIENLEEYTGLRCLWLQSNGIQKIEN 146
Query: 116 LEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNK 175
LE LR L L N ++KIENLE L +L+ L++S N ++ IE + L L L + +N
Sbjct: 147 LEAQTELRCLFLQMNLLRKIENLEPLQKLDALNLSNNYIKTIENLSCLPVLNTLQMAHNH 206
Query: 176 ISKIENLSNLHQ---LQMLELGSNRIRAIENIDTLTNLESL 213
+ +E++ +L + L +L+L N++ E + L ++ L
Sbjct: 207 LETVEDIQHLQECLRLCVLDLSHNKLSDPEILSILESMPDL 247
>gi|206725447 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 87.4 bits (215), Expect = 2e-17
Identities = 88/340 (25%), Positives = 151/340 (44%), Gaps = 41/340 (12%)
Query: 24 SEESGDEEGKKHSSGIVADLSEQSLKDGEE---RGEEDPEEEHELPVDMETINLDRDAED 80
S+E E+ + + E+ ++GE+ GEE PEE P+ + +
Sbjct: 2 SDEDDLEDSEPDQDDSEKEEDEKETEEGEDYRKEGEEFPEEWLPTPLTEDMMK------- 54
Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
EG +L K L LE ++E DL D I L +
Sbjct: 55 -----------EGLSLLCKTGN-----GLAHAYVKLE----VKERDLTD-----IYLLRS 89
Query: 141 LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRA 200
L +DIS N L ++ ++ LT L L N++ + ++ L LQ+ N+I
Sbjct: 90 YIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQ-MNELPYLQIASFAYNQITD 148
Query: 201 IENIDTLTNLESLFLGKNKITKLQNLDA--LTNLTVLSMQSNRLTKIEGLQNLVNLRELY 258
E I LE+L L N I + LD L +L + ++ N+L G+ NL L+ LY
Sbjct: 149 TEGISH-PRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGI-NLPKLKNLY 206
Query: 259 LSHNGIEVIEGLENNNKLTMLDIASNRIKKIENIS-HLTELQEFWMNDNLLESWSDLDEL 317
L+ N ++ +EGLE+ + LT L + N+I + S + LQ + N++ + +L +L
Sbjct: 207 LAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGELAKL 266
Query: 318 KGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATF 357
+ L + L NP + YR++ ++ +P + ++D F
Sbjct: 267 RDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEF 306
>gi|42542396 leucine rich repeat containing 23 isoform a [Homo
sapiens]
Length = 343
Score = 87.4 bits (215), Expect = 2e-17
Identities = 88/340 (25%), Positives = 151/340 (44%), Gaps = 41/340 (12%)
Query: 24 SEESGDEEGKKHSSGIVADLSEQSLKDGEE---RGEEDPEEEHELPVDMETINLDRDAED 80
S+E E+ + + E+ ++GE+ GEE PEE P+ + +
Sbjct: 2 SDEDDLEDSEPDQDDSEKEEDEKETEEGEDYRKEGEEFPEEWLPTPLTEDMMK------- 54
Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
EG +L K L LE ++E DL D I L +
Sbjct: 55 -----------EGLSLLCKTGN-----GLAHAYVKLE----VKERDLTD-----IYLLRS 89
Query: 141 LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRA 200
L +DIS N L ++ ++ LT L L N++ + ++ L LQ+ N+I
Sbjct: 90 YIHLRYVDISENHLTDLSPLNYLTHLLWLKADGNRLRSAQ-MNELPYLQIASFAYNQITD 148
Query: 201 IENIDTLTNLESLFLGKNKITKLQNLDA--LTNLTVLSMQSNRLTKIEGLQNLVNLRELY 258
E I LE+L L N I + LD L +L + ++ N+L G+ NL L+ LY
Sbjct: 149 TEGISH-PRLETLNLKGNSIHMVTGLDPEKLISLHTVELRGNQLESTLGI-NLPKLKNLY 206
Query: 259 LSHNGIEVIEGLENNNKLTMLDIASNRIKKIENIS-HLTELQEFWMNDNLLESWSDLDEL 317
L+ N ++ +EGLE+ + LT L + N+I + S + LQ + N++ + +L +L
Sbjct: 207 LAQNMLKKVEGLEDLSNLTTLHLRDNQIDTLSGFSREMKSLQYLNLRGNMVANLGELAKL 266
Query: 318 KGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQIDATF 357
+ L + L NP + YR++ ++ +P + ++D F
Sbjct: 267 RDLPKLRALVLLDNPCTDETSYRQEALVQMPYLERLDKEF 306
>gi|117414162 sodium channel associated protein 2 isoform a [Homo
sapiens]
Length = 1032
Score = 85.9 bits (211), Expect = 5e-17
Identities = 63/206 (30%), Positives = 102/206 (49%), Gaps = 29/206 (14%)
Query: 157 IEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLG 216
+E D + + ++ + I LS L + L N I IE ID + NL+ L L
Sbjct: 14 VENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDLS 73
Query: 217 KNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGL----EN 272
N+I++++ L+ LT L L++ N +TK+EGL+ L+NL L +S+N I+ + GL
Sbjct: 74 SNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHGI 133
Query: 273 NNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLER-- 330
+KL +D+ SNR I++I HL L + G L + LE+
Sbjct: 134 KHKLRYIDLHSNR---IDSIHHL------------------LQCMVGLHFLTNLILEKDG 172
Query: 331 --NPLQKDPQYRRKVMLALPSVRQID 354
NP+ + P YR ++ LP +R +D
Sbjct: 173 DDNPVCRLPGYRAVILQTLPQLRILD 198
Score = 68.9 bits (167), Expect = 7e-12
Identities = 64/218 (29%), Positives = 107/218 (49%), Gaps = 16/218 (7%)
Query: 68 DMETINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDL 127
++E + D DV + I + + + L N I IE ++ + +L+ LDL
Sbjct: 13 EVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDL 72
Query: 128 YDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNL-- 185
NQI +IE L LT+L L++S NL+ +EG+++L L +L + N I + L L
Sbjct: 73 SSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSYNHIDDLSGLIPLHG 132
Query: 186 --HQLQMLELGSNRIRAIENI----DTLTNLESLFLGK----NKITKLQNLDALTNLTVL 235
H+L+ ++L SNRI +I ++ L L +L L K N + +L A+ T+
Sbjct: 133 IKHKLRYIDLHSNRIDSIHHLLQCMVGLHFLTNLILEKDGDDNPVCRLPGYRAVILQTLP 192
Query: 236 SMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENN 273
++ I G VNL E+ S ++ +EGL +N
Sbjct: 193 QLRILDCKNIFG--EPVNLTEINSSQ--LQCLEGLLDN 226
Score = 40.0 bits (92), Expect = 0.003
Identities = 29/106 (27%), Positives = 50/106 (47%)
Query: 222 KLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDI 281
+++N D ++ + L I L L + L N I IE +++ L LD+
Sbjct: 13 EVENEDGDSSCGDVCFMDKGLQSISELSLDSTLHAVNLHCNNISKIEAIDHIWNLQHLDL 72
Query: 282 ASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVY 327
+SN+I +IE ++ LT+L ++ NL+ L+EL L Y
Sbjct: 73 SSNQISRIEGLNTLTKLCTLNLSCNLITKVEGLEELINLTRLNVSY 118
>gi|31377705 centrosomal protein 97kDa [Homo sapiens]
Length = 865
Score = 83.2 bits (204), Expect = 3e-16
Identities = 63/194 (32%), Positives = 92/194 (47%), Gaps = 20/194 (10%)
Query: 107 QNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRL 166
Q L K NL + L L NQI K+ENLE L L ++ N L + GV KLT L
Sbjct: 23 QGLQKLGPNLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLL 82
Query: 167 KKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNL 226
+ L L +N I +E L L L+ L L N ++A+E I++ T L+ L L N I+++ +L
Sbjct: 83 RVLNLPHNSIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDL 142
Query: 227 DALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRI 286
L +L L + N +T + + YL + L +L +A N I
Sbjct: 143 SKLVSLKTLLLHGNIITSL-------RMAPAYLPRS-------------LAILSLAENEI 182
Query: 287 KKIENISHLTELQE 300
+ + IS L L E
Sbjct: 183 RDLNEISFLASLTE 196
Score = 80.1 bits (196), Expect = 3e-15
Identities = 48/129 (37%), Positives = 73/129 (56%), Gaps = 3/129 (2%)
Query: 203 NIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 262
N+ ++ +L L KN+I KL+NL+ L LS+ +NRL ++ G+ L LR L L HN
Sbjct: 31 NLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHN 90
Query: 263 GIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARS 322
I +EGL+ L L++A N +K +E I+ T LQ ++DN + DL +L S
Sbjct: 91 SIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLV---S 147
Query: 323 LETVYLERN 331
L+T+ L N
Sbjct: 148 LKTLLLHGN 156
Score = 67.4 bits (163), Expect = 2e-11
Identities = 38/130 (29%), Positives = 71/130 (54%)
Query: 181 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 240
NL + L L N+I +EN++ L L + N++ ++ + LT L VL++ N
Sbjct: 31 NLPCEADIHTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHN 90
Query: 241 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQE 300
+ +EGL+ LV+L L L+ N ++ +E + + L LD++ N I +I ++S L L+
Sbjct: 91 SIGCVEGLKELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKT 150
Query: 301 FWMNDNLLES 310
++ N++ S
Sbjct: 151 LLLHGNIITS 160
Score = 65.9 bits (159), Expect = 6e-11
Identities = 55/185 (29%), Positives = 87/185 (47%), Gaps = 18/185 (9%)
Query: 63 HELPVDMETI----NLDRDAEDVDLN--HYRIGKIEGFEVLKKVKTLCLRQNLIKCIENL 116
H L +D I NL++ + L+ + R+ ++ G L ++ L L N I C+E L
Sbjct: 39 HTLILDKNQIIKLENLEKCKRLIQLSVANNRLVRMMGVAKLTLLRVLNLPHNSIGCVEGL 98
Query: 117 EELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKI 176
+EL L L+L N +K +E + + T L+ LD+S N + I + KL LK L L N I
Sbjct: 99 KELVHLEWLNLAGNNLKAMEQINSCTALQHLDLSDNNISQIGDLSKLVSLKTLLLHGNII 158
Query: 177 SKIENLSNL--HQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTV 234
+ + L +L L N IR + I L +L T+L+ L + N V
Sbjct: 159 TSLRMAPAYLPRSLAILSLAENEIRDLNEISFLASL----------TELEQLSIMNNPCV 208
Query: 235 LSMQS 239
++ S
Sbjct: 209 MATPS 213
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 82.0 bits (201), Expect = 7e-16
Identities = 81/289 (28%), Positives = 135/289 (46%), Gaps = 42/289 (14%)
Query: 105 LRQNLIKCIENLEELQSLRELDLY-----DNQIKKIENLEALTELEILDISFNLLRNIEG 159
+ + LIK + + L ++ L+L + K IENLE +LE+L++S+NL+ IE
Sbjct: 83 ITEALIKKLTKQDNLALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEK 142
Query: 160 VDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENI--DTLTNLESLFLGK 217
+DKL +L++L L NKISKIE + N+ LQ L L N I I L +L L L
Sbjct: 143 LDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKG 202
Query: 218 NKITKLQNLDALTNL----------------------TVLSMQSNRLTKIEGLQNLVNLR 255
NKI+ LQ++ L L T+ ++S L +EG R
Sbjct: 203 NKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRS--LESLEGQPVTTQDR 260
Query: 256 ELYLSHNGIEVIEGLENNNKLTML---DIASNRIKKIENISHLTELQEFWMNDNLLESWS 312
+ +E +E LE + + M+ ++ S + + +E I + +L + + +L+ S
Sbjct: 261 QEAFERFSLEEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQS 320
Query: 313 DLDELKGARSLETVYLERNPLQK----DPQYRRKVMLALPSVRQIDATF 357
+ELK + + L++ ++ QY + LA +IDA F
Sbjct: 321 -CEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAF---YKIDAKF 365
Score = 38.5 bits (88), Expect = 0.009
Identities = 60/256 (23%), Positives = 111/256 (43%), Gaps = 48/256 (18%)
Query: 33 KKHSSGIVADLSEQSLKDGEERGEEDPEEEHELPVDMETINLDRDA-------------E 79
K+ + ++ L+ KDG ++ + E E V +E +NL +
Sbjct: 93 KQDNLALIKSLNLSLSKDGGKKFKYI--ENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLR 150
Query: 80 DVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENL--EELQSLRELDLYDNQIKKIEN 137
+++L++ +I KIEG E + ++ L L N I+ I ++L+SLR L+L N+I +++
Sbjct: 151 ELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPVWLGKKLKSLRVLNLKGNKISSLQD 210
Query: 138 LEALTELEILDISFNLLRN---------------------IEGVDKLTRLKKLFLVNNKI 176
+ L L+ L IS L+ N +EG T+ ++ +
Sbjct: 211 ISKLKPLQDL-ISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSL 269
Query: 177 SKIENLSNLHQLQML---ELGSNRIRAIENIDTLTNL-----ESLFLGKNKITKLQNLDA 228
++E L + +M+ EL S + R +E I L E L K +L++ D
Sbjct: 270 EEVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKS-DL 328
Query: 229 LTNLTVLSMQSNRLTK 244
T +L ++ LT+
Sbjct: 329 NTKNELLKQKTIELTR 344
Score = 30.0 bits (66), Expect = 3.4
Identities = 53/265 (20%), Positives = 107/265 (40%), Gaps = 26/265 (9%)
Query: 101 KTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGV 160
+ L R N K Q E+ +K +E ++ LT+L++ + R + +
Sbjct: 892 RALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQL 951
Query: 161 DKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLF-----L 215
+L + KKL ++ L +L+ S+++ E L+SL +
Sbjct: 952 RELEKKKKLEDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKI 1011
Query: 216 GKNKITKLQNLDALTNLTVLSMQ--SNRLTKIEGLQNLVNLR----ELYLSHNGI----- 264
+ + +LQ + + + + + +IE LQNL+ + L + G+
Sbjct: 1012 NQERAEELQEAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQFRLEMEKTGVGTGAN 1071
Query: 265 -EVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSL 323
+V+E +E N+ ++ I +++N+ LT +N+LE ++ EL+ S
Sbjct: 1072 SQVLE-IEKLNE--TMERQRTEIARLQNVLDLTGSDNKGGFENVLE---EIAELRREVSY 1125
Query: 324 ETVYLERNPLQKDPQYRRKVMLALP 348
+ Y+ DP RR +P
Sbjct: 1126 QNDYISS---MADPFKRRGYWYFMP 1147
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 80.9 bits (198), Expect = 2e-15
Identities = 62/182 (34%), Positives = 101/182 (55%), Gaps = 8/182 (4%)
Query: 164 TRLKKLFLVNNKISKI-ENLSNLHQLQMLELGSNRIRAIEN-IDTLTNLESLFLGKNKIT 221
T L KL + NNK+ + ++L L L +L++ N++ ++ + I L NL+ L + NK+
Sbjct: 82 TDLTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLK 141
Query: 222 KL-QNLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRELYLSHNGIEVIEG-LENNNKLTM 278
L + + L NL L +Q N LT I EG + L NL +L LS+N + + + + L
Sbjct: 142 ILPEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVR 201
Query: 279 LDIASNRIKKIE-NISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDP 337
L+++SN +K + I+ + L+ N NLLE+ EL G SLE +YL RN L+ P
Sbjct: 202 LNLSSNELKSLPAEINRMKRLKHLDCNSNLLETIPP--ELAGMESLELLYLRRNKLRFLP 259
Query: 338 QY 339
++
Sbjct: 260 EF 261
Score = 75.9 bits (185), Expect = 5e-14
Identities = 71/265 (26%), Positives = 132/265 (49%), Gaps = 34/265 (12%)
Query: 101 KTLCLRQNLIKCIENLEELQSLRELDLYDNQ-------IKKIENLEALT----ELEILDI 149
K + L ++L L +L LD++DNQ I+++ENL+ L +L+IL
Sbjct: 86 KLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKILPE 145
Query: 150 SFNLLRNI--------------EGVDKLTRLKKLFLVNNKISKIE-NLSNLHQLQMLELG 194
LRN+ EG ++L+ L+ L L NN ++ + + S+L L L L
Sbjct: 146 EITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLNLS 205
Query: 195 SNRIRAIE-NIDTLTNLESLFLGKNKITKLQ-NLDALTNLTVLSMQSNRLTKIEGLQNLV 252
SN ++++ I+ + L+ L N + + L + +L +L ++ N+L + +
Sbjct: 206 SNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPSCS 265
Query: 253 NLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLE 309
L+EL++ N IE++E L++ N + +LD+ N++K + + I L L+ +++N +
Sbjct: 266 LLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDI- 324
Query: 310 SWSDLDELKGARSLETVYLERNPLQ 334
S L G L+ + LE NPL+
Sbjct: 325 --SSLPYSLGNLHLKFLALEGNPLR 347
Score = 52.0 bits (123), Expect = 8e-07
Identities = 72/298 (24%), Positives = 130/298 (43%), Gaps = 59/298 (19%)
Query: 97 LKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKI--ENLEALTELEILDISFNLL 154
++ ++ L LR+N ++ + L+EL + +NQI+ + E+L+ L + +LD+ N L
Sbjct: 242 MESLELLYLRRNKLRFLPEFPSCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKL 301
Query: 155 RNI-EGVDKLTRLKKLFLVNNKISKIE-NLSNLHQLQMLELGSNRIRAIE---------- 202
+++ + + L L++L L NN IS + +L NLH L+ L L N +R I
Sbjct: 302 KSVPDEIILLRSLERLDLSNNDISSLPYSLGNLH-LKFLALEGNPLRTIRREIISKGTQE 360
Query: 203 ---------------------------------NIDTLTNLESLFLGKNKITKLQN--LD 227
NI + L+ L + T + + D
Sbjct: 361 VLKYLRSKIKDDGPSQSESATETAMTLPSESRVNIHAIITLKILDYSDKQATLIPDEVFD 420
Query: 228 ALTNLTVLSMQSNRLTKIEGLQNLVNLRELY----LSHNGIEVIE-GLENNNKLTMLDIA 282
A+ + V S+ ++ E + +V L+E+ LS N + I L KLT LD+
Sbjct: 421 AVKSNIVTSINFSKNQLCEIPKRMVELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLR 480
Query: 283 SNRIKKI-ENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL-QKDPQ 338
+N + + E + L LQ ++ N + ++ L +LET+ + N + DPQ
Sbjct: 481 NNFLNSLPEEMESLVRLQTINLSFNRFKMLPEV--LYRIFTLETILISNNQVGSVDPQ 536
Score = 50.8 bits (120), Expect = 2e-06
Identities = 42/126 (33%), Positives = 68/126 (53%), Gaps = 6/126 (4%)
Query: 147 LDISFNLLRNIE-GVDKLTRLKKLFLVNNKISKI-ENLSNLHQLQMLELGSNRIRAI-EN 203
+D+SFN L I + L +L L L NN ++ + E + +L +LQ + L NR + + E
Sbjct: 454 VDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFNRFKMLPEV 513
Query: 204 IDTLTNLESLFLGKNKITKL--QNLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRELYLS 260
+ + LE++ + N++ + Q + + NLT L +Q+N L +I L N VNLR L L
Sbjct: 514 LYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCVNLRTLLLD 573
Query: 261 HNGIEV 266
N V
Sbjct: 574 GNPFRV 579
>gi|197333692 leucine rich repeat containing 8 family, member B
[Homo sapiens]
Length = 803
Score = 80.1 bits (196), Expect = 3e-15
Identities = 84/263 (31%), Positives = 134/263 (50%), Gaps = 18/263 (6%)
Query: 90 KIEGFEVLKKVKTLCLRQNLIKCIENLEE-LQSLRELDLYDNQIKK---IENLEALTELE 145
++EGF+ LK ++TL L+ +L + + + + L SL++L L DN+ K + NL+ + L+
Sbjct: 530 QLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLK 588
Query: 146 ILD-ISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENL---SNLHQLQMLELGSNRIRAI 201
L+ IS +L R + L L +L L N + +E + +L L L+L N I I
Sbjct: 589 SLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYI 648
Query: 202 -ENIDTLTNLESLFLGKNKITKLQ-NLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRELY 258
I L+NLE L L N I L L T L L + N LT I E +Q L NL+
Sbjct: 649 PAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFA 708
Query: 259 LSHNGIEVI-EGLENNNKLTMLDIASNRIKKIE-NISHLTELQEFWMNDNLLESWSDLDE 316
+++N IE++ +GL KL L + N + + ++ L+ L + N LE+ E
Sbjct: 709 VTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLP--PE 766
Query: 317 LKGARSLE--TVYLERNPLQKDP 337
L+G +SL+ + +E N L P
Sbjct: 767 LEGCQSLKRNCLIVEENLLNTLP 789
>gi|21245134 leucine rich repeat containing 8 family, member B [Homo
sapiens]
Length = 803
Score = 80.1 bits (196), Expect = 3e-15
Identities = 84/263 (31%), Positives = 134/263 (50%), Gaps = 18/263 (6%)
Query: 90 KIEGFEVLKKVKTLCLRQNLIKCIENLEE-LQSLRELDLYDNQIKK---IENLEALTELE 145
++EGF+ LK ++TL L+ +L + + + + L SL++L L DN+ K + NL+ + L+
Sbjct: 530 QLEGFQDLKNLRTLYLKSSLSRIPQVVTDLLPSLQKLSL-DNEGSKLVVLNNLKKMVNLK 588
Query: 146 ILD-ISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENL---SNLHQLQMLELGSNRIRAI 201
L+ IS +L R + L L +L L N + +E + +L L L+L N I I
Sbjct: 589 SLELISCDLERIPHSIFSLNNLHELDLRENNLKTVEEIISFQHLQNLSCLKLWHNNIAYI 648
Query: 202 -ENIDTLTNLESLFLGKNKITKLQ-NLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRELY 258
I L+NLE L L N I L L T L L + N LT I E +Q L NL+
Sbjct: 649 PAQIGALSNLEQLSLDHNNIENLPLQLFLCTKLHYLDLSYNHLTFIPEEIQYLSNLQYFA 708
Query: 259 LSHNGIEVI-EGLENNNKLTMLDIASNRIKKIE-NISHLTELQEFWMNDNLLESWSDLDE 316
+++N IE++ +GL KL L + N + + ++ L+ L + N LE+ E
Sbjct: 709 VTNNNIEMLPDGLFQCKKLQCLLLGKNSLMNLSPHVGELSNLTHLELIGNYLETLP--PE 766
Query: 317 LKGARSLE--TVYLERNPLQKDP 337
L+G +SL+ + +E N L P
Sbjct: 767 LEGCQSLKRNCLIVEENLLNTLP 789
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform 1
[Homo sapiens]
Length = 1722
Score = 77.0 bits (188), Expect = 2e-14
Identities = 74/306 (24%), Positives = 134/306 (43%), Gaps = 46/306 (15%)
Query: 98 KKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNI 157
KK+K + ++N I+ IE E L++L + L NQ+ + L+ T ++ L++S+N + I
Sbjct: 840 KKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRI 898
Query: 158 --------EGVDK-------------------------------LTRLKKLFLVNNKISK 178
+ VD +T L K N IS
Sbjct: 899 GYSFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISH 958
Query: 179 IE---NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVL 235
+ L +L LQ L L N++ + + + L N +T ++ ++ L +L
Sbjct: 959 LYWNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQIL 1018
Query: 236 SMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENN--NKLTMLDIASNRIKKIENIS 293
+Q N L+++ L+NLV LREL+L N I +E + L + I+ N + KI +
Sbjct: 1019 KLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLF 1078
Query: 294 HLTELQEFWMNDNLLESW-SDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQ 352
H L++ ++ N L S + SL + L NPL ++ +R ++ LP++R
Sbjct: 1079 HFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRI 1138
Query: 353 IDATFV 358
++ +
Sbjct: 1139 LNGNIL 1144
Score = 53.5 bits (127), Expect = 3e-07
Identities = 40/145 (27%), Positives = 75/145 (51%), Gaps = 8/145 (5%)
Query: 101 KTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGV 160
K + R+ +KC N+ +L +L++ + + L+ +T + D+ +L +
Sbjct: 762 KKIVRRKRPVKCPANMTP--ALDKLEIL--RCGPWDTLQQVTTVTFQDLPGCVLSTLA-- 815
Query: 161 DKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKI 220
+ T L+ L L ++ + +LSN +L+ ++ N I AIE + L NL + L KN++
Sbjct: 816 -ECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQL 873
Query: 221 TKLQNLDALTNLTVLSMQSNRLTKI 245
T L LD TN+ L + N++T+I
Sbjct: 874 TSLHGLDGCTNIQCLELSYNKITRI 898
Score = 44.3 bits (103), Expect = 2e-04
Identities = 32/103 (31%), Positives = 54/103 (52%), Gaps = 2/103 (1%)
Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
+D +H + +EG E ++ L L+ N + + +LE L LREL L DN I +E +
Sbjct: 996 LDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSS 1055
Query: 141 --LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN 181
L L+ + IS N L I + L+KL + +N +S +++
Sbjct: 1056 YWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKS 1098
Score = 41.2 bits (95), Expect = 0.001
Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 208 TNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVI 267
TNL+ L L + +T L +L L + Q N + IE +NL NL + L+ N + +
Sbjct: 818 TNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQLTSL 876
Query: 268 EGLENNNKLTMLDIASNRIKKI 289
GL+ + L+++ N+I +I
Sbjct: 877 HGLDGCTNIQCLELSYNKITRI 898
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform 2
[Homo sapiens]
Length = 1336
Score = 77.0 bits (188), Expect = 2e-14
Identities = 74/306 (24%), Positives = 134/306 (43%), Gaps = 46/306 (15%)
Query: 98 KKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNI 157
KK+K + ++N I+ IE E L++L + L NQ+ + L+ T ++ L++S+N + I
Sbjct: 840 KKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQLTSLHGLDGCTNIQCLELSYNKITRI 898
Query: 158 --------EGVDK-------------------------------LTRLKKLFLVNNKISK 178
+ VD +T L K N IS
Sbjct: 899 GYSFFLEEKLVDNAGFCHHLGTSTSYLSLAQVWIPTGLCWSWIPITSLTKNSDCNFLISH 958
Query: 179 IE---NLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVL 235
+ L +L LQ L L N++ + + + L N +T ++ ++ L +L
Sbjct: 959 LYWNCGLESLKNLQQLILDHNQLINTKGLCDTPTIVYLDCSHNHLTDVEGVENCGLLQIL 1018
Query: 236 SMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENN--NKLTMLDIASNRIKKIENIS 293
+Q N L+++ L+NLV LREL+L N I +E + L + I+ N + KI +
Sbjct: 1019 KLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSSYWLPLLQNITISQNSLTKIVPLF 1078
Query: 294 HLTELQEFWMNDNLLESW-SDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQ 352
H L++ ++ N L S + SL + L NPL ++ +R ++ LP++R
Sbjct: 1079 HFVSLEKLDVSHNCLSDLKSAIKWFDACYSLHELSLTGNPLLQETNWRDSLLKVLPALRI 1138
Query: 353 IDATFV 358
++ +
Sbjct: 1139 LNGNIL 1144
Score = 53.5 bits (127), Expect = 3e-07
Identities = 40/145 (27%), Positives = 75/145 (51%), Gaps = 8/145 (5%)
Query: 101 KTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGV 160
K + R+ +KC N+ +L +L++ + + L+ +T + D+ +L +
Sbjct: 762 KKIVRRKRPVKCPANMTP--ALDKLEIL--RCGPWDTLQQVTTVTFQDLPGCVLSTLA-- 815
Query: 161 DKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKI 220
+ T L+ L L ++ + +LSN +L+ ++ N I AIE + L NL + L KN++
Sbjct: 816 -ECTNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQL 873
Query: 221 TKLQNLDALTNLTVLSMQSNRLTKI 245
T L LD TN+ L + N++T+I
Sbjct: 874 TSLHGLDGCTNIQCLELSYNKITRI 898
Score = 44.3 bits (103), Expect = 2e-04
Identities = 32/103 (31%), Positives = 54/103 (52%), Gaps = 2/103 (1%)
Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
+D +H + +EG E ++ L L+ N + + +LE L LREL L DN I +E +
Sbjct: 996 LDCSHNHLTDVEGVENCGLLQILKLQGNYLSELPSLENLVLLRELHLDDNSISTVEAFSS 1055
Query: 141 --LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIEN 181
L L+ + IS N L I + L+KL + +N +S +++
Sbjct: 1056 YWLPLLQNITISQNSLTKIVPLFHFVSLEKLDVSHNCLSDLKS 1098
Score = 41.2 bits (95), Expect = 0.001
Identities = 25/82 (30%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 208 TNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVI 267
TNL+ L L + +T L +L L + Q N + IE +NL NL + L+ N + +
Sbjct: 818 TNLQFLSLRRCGLTSLHSLSNCKKLKYIDAQENHIEAIE-CENLENLCVVLLNKNQLTSL 876
Query: 268 EGLENNNKLTMLDIASNRIKKI 289
GL+ + L+++ N+I +I
Sbjct: 877 HGLDGCTNIQCLELSYNKITRI 898
>gi|61966709 leucine rich repeat containing 67 [Homo sapiens]
Length = 228
Score = 76.6 bits (187), Expect = 3e-14
Identities = 63/197 (31%), Positives = 97/197 (49%), Gaps = 12/197 (6%)
Query: 166 LKKLFLVN---NKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITK 222
LKK+ +N I IE+LS L +L L N I I N++ TNL L+L N I+
Sbjct: 27 LKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISC 86
Query: 223 LQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGL--------ENNN 274
++NL +L L L + N + IEGL+ L LREL++ + + + E L
Sbjct: 87 IENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAK 146
Query: 275 KLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLD-ELKGARSLETVYLERNPL 333
L +L+I++N I I ++ L L + DN L DL+ L L + L NP+
Sbjct: 147 SLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLMKLWKIDLNGNPV 206
Query: 334 QKDPQYRRKVMLALPSV 350
P+YR +++L S+
Sbjct: 207 CLKPKYRDRLILVSKSL 223
Score = 70.9 bits (172), Expect = 2e-12
Identities = 54/167 (32%), Positives = 84/167 (50%), Gaps = 8/167 (4%)
Query: 95 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLL 154
+ LKK+ + I IE+L ++L L LYDN I +I NL T L L + N +
Sbjct: 25 QCLKKITHINFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCI 84
Query: 155 RNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENI----DTLTNL 210
IE + L +L+KL+L N I+ IE L L +L+ L + + R+ E + TL +L
Sbjct: 85 SCIENLRSLKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSL 144
Query: 211 ES----LFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVN 253
L + N I + +L+ L NL L N+L ++ L+ L+N
Sbjct: 145 AKSLCILNISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLN 191
Score = 67.4 bits (163), Expect = 2e-11
Identities = 56/186 (30%), Positives = 90/186 (48%), Gaps = 14/186 (7%)
Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
++ + I IE + K + L L N I I NL +L L L +N I IENL +
Sbjct: 33 INFSDKNIDAIEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRS 92
Query: 141 LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENL----SNLHQLQ----MLE 192
L +LE L + N + IEG++ L L++L + N ++ E L LH L +L
Sbjct: 93 LKKLEKLYLGGNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILN 152
Query: 193 LGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLV 252
+ +N I I +++ L NL L N++ +++L+ L N + +L KI+ N V
Sbjct: 153 ISNNNIDDITDLELLENLNQLIAVDNQLLHVKDLEFLLNKLM------KLWKIDLNGNPV 206
Query: 253 NLRELY 258
L+ Y
Sbjct: 207 CLKPKY 212
Score = 51.6 bits (122), Expect = 1e-06
Identities = 49/164 (29%), Positives = 80/164 (48%), Gaps = 11/164 (6%)
Query: 69 METINLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLY 128
+E ++L ++ + L I +I + L L+ N I CIENL L+ L +L L
Sbjct: 43 IEDLSLCKNLSVLYLYDNCISQITNLNYATNLTHLYLQNNCISCIENLRSLKKLEKLYLG 102
Query: 129 DNQIKKIENLEALTELEILDISFNLLRNIEGV--DKLT---RLKKLFLVNNKISKIENLS 183
N I IE LE L EL L + L E + D T K L ++N + I++++
Sbjct: 103 GNYIAVIEGLEGLGELRELHVENQRLPLGEKLLFDPRTLHSLAKSLCILNISNNNIDDIT 162
Query: 184 NLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD 227
+L L+ L N++ A++N L +++ L NK+ KL +D
Sbjct: 163 DLELLENL----NQLIAVDN--QLLHVKDLEFLLNKLMKLWKID 200
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 76.3 bits (186), Expect = 4e-14
Identities = 82/329 (24%), Positives = 151/329 (45%), Gaps = 59/329 (17%)
Query: 63 HELPVDMETINLDRDAEDVDLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCI-ENLEELQ 120
+E+P E+I+ + + D + + ++ E F L+ + L + ++ + EN+ L
Sbjct: 92 NEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLY 151
Query: 121 SLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVNNKISK 178
+L L+L +N + + ++L L LE LD+ N + N+ E + L LK L+L N++S+
Sbjct: 152 NLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSE 211
Query: 179 I-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVL 235
+ + + NL L L++ NR+ + E I LT+L L + +N + + + + L L++L
Sbjct: 212 LPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSIL 271
Query: 236 SMQSNRLTKI-EGLQNLVNLRELYLSHN-------GIEVIEGLEN--------------- 272
+ NRLT++ E + +L EL L+ N I ++ L N
Sbjct: 272 KVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEI 331
Query: 273 ------------NNKLT-------------MLDIASNRIKKIENISHLTELQEFWMNDN- 306
+N+LT +LD+A NR+ + +L+ W++DN
Sbjct: 332 GGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPLSLTALKLKALWLSDNQ 391
Query: 307 ---LLESWSDLDELKGARSLETVYLERNP 332
LL +D D G + L V L + P
Sbjct: 392 SQPLLTFQTDTDYTTGEKILTCVLLPQLP 420
Score = 73.6 bits (179), Expect = 3e-13
Identities = 83/306 (27%), Positives = 146/306 (47%), Gaps = 37/306 (12%)
Query: 67 VDMETINLDRDAEDVDLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCIE-NLEELQSLRE 124
V E R E++ L+ ++ ++ E F L K++ L L N I+ + + L E
Sbjct: 27 VPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQRLPPEIANFMQLVE 86
Query: 125 LDLYDNQIKKI-ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVNNKISKI-EN 181
LD+ N+I +I E++ L++ D S N L + E +L L L + + + + EN
Sbjct: 87 LDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPEN 146
Query: 182 LSNLHQLQMLELGSN----------RIRAIENID--------------TLTNLESLFLGK 217
+ NL+ L LEL N ++R +E +D L +L+ L+L
Sbjct: 147 IGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDG 206
Query: 218 NKITKL-QNLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRELYLSHNGIEVI-EGLENNN 274
N++++L Q + L NL L + NRL ++ E + L +L +L +S N +E I +G+
Sbjct: 207 NQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLK 266
Query: 275 KLTMLDIASNRIKKI-ENISHLTELQEFWMNDN-LLESWSDLDELKGARSLETVYLERNP 332
KL++L + NR+ ++ E + L E + +N LL + +LK L + +RN
Sbjct: 267 KLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLK---KLSNLNADRNK 323
Query: 333 LQKDPQ 338
L P+
Sbjct: 324 LVSLPK 329
>gi|19923729 leucine rich repeat containing 8 family, member C [Homo
sapiens]
Length = 803
Score = 74.3 bits (181), Expect = 2e-13
Identities = 73/231 (31%), Positives = 120/231 (51%), Gaps = 12/231 (5%)
Query: 113 IENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGV-DKLTRLKKLFL 171
+ NLEEL + L ++ +E+L L L+IL I N+ + + V D + L+K+ +
Sbjct: 513 LRNLEELYLVGSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCI 572
Query: 172 VNN--KISKIENLSNLHQLQMLELGSNRIRAIEN-IDTLTNLESLFLGKNKITKLQNLDA 228
N+ K+ + NL + L LEL + I + + +L +L+ L L +N + ++ + +
Sbjct: 573 HNDGTKLVMLNNLKKMTNLTELELVHCDLERIPHAVFSLLSLQELDLKENNLKSIEEIVS 632
Query: 229 ---LTNLTVLSMQSNRLTKI-EGLQNLVNLRELYLSHNGIEVIEG-LENNNKLTMLDIAS 283
L LTVL + N +T I E ++ L +L L SHN IEV+ L NK+ LD++
Sbjct: 633 FQHLRKLTVLKLWHNSITYIPEHIKKLTSLERLSFSHNKIEVLPSHLFLCNKIRYLDLSY 692
Query: 284 NRIKKI-ENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL 333
N I+ I I L LQ F + N +ES DEL + L+T+ + +N L
Sbjct: 693 NDIRFIPPEIGVLQSLQYFSITCNKVESLP--DELYFCKKLKTLKIGKNSL 741
Score = 39.3 bits (90), Expect = 0.006
Identities = 56/240 (23%), Positives = 106/240 (44%), Gaps = 55/240 (22%)
Query: 116 LEELQSLRELDLYDNQIK-KIENLEALTE-LEILDISFNLLRNIEG-VDKLTRLKKLFLV 172
+ +L +L+EL L+ +K L L E L++L + F+ +R + + L L++L+LV
Sbjct: 463 IAQLDNLQELSLHQCSVKIHSAALSFLKENLKVLSVKFDDMRELPPWMYGLRNLEELYLV 522
Query: 173 ---NNKISK---IENLSNLHQLQMLELGSNRIRAIENI-DTLTNLESLFLGKN--KITKL 223
++ IS+ +E+L +L L++L + SN + + + D ++L+ + + + K+ L
Sbjct: 523 GSLSHDISRNVTLESLRDLKSLKILSIKSNVSKIPQAVVDVSSHLQKMCIHNDGTKLVML 582
Query: 224 QNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIAS 283
NL +TNLT EL L H +E I
Sbjct: 583 NNLKKMTNLT----------------------ELELVHCDLERIP--------------- 605
Query: 284 NRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKV 343
+ L LQE + +N L+S ++ + R L + L N + P++ +K+
Sbjct: 606 ------HAVFSLLSLQELDLKENNLKSIEEIVSFQHLRKLTVLKLWHNSITYIPEHIKKL 659
>gi|62241040 leucine rich repeat containing 8 family, member A [Homo
sapiens]
Length = 810
Score = 73.6 bits (179), Expect = 3e-13
Identities = 74/236 (31%), Positives = 118/236 (50%), Gaps = 22/236 (9%)
Query: 91 IEGFEVLKKVKTLCLRQNLIKCIENLEEL-QSLRELDLYD--------NQIKKIENLEAL 141
I+G LK++K L L+ NL K + + ++ L++L + + N +KK+ N L
Sbjct: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMAN---L 593
Query: 142 TELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENL---SNLHQLQMLELGSNRI 198
TELE+ I +L R + L L+++ L +N + IE + +LH+L L+L N I
Sbjct: 594 TELEL--IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651
Query: 199 RAIE-NIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEG-LQNLVNLR 255
I I LTNLE L+L +NKI K+ L L L + N LT + + L NL+
Sbjct: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711
Query: 256 ELYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLE 309
L ++ N IE + L KL L + +N ++ + + LT L + + N LE
Sbjct: 712 NLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/183 (30%), Positives = 92/183 (50%), Gaps = 12/183 (6%)
Query: 97 LKKVKTLC----LRQNLIKCIENLEELQSLRELDLYDNQIKKIENL---EALTELEILDI 149
LKK+ L +R +L + ++ L +L+E+DL DN +K IE + + L L L +
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 150 SFNLLRNIE-GVDKLTRLKKLFLVNNKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDT 206
+N + I + LT L++L+L NKI KI L +L+ L+L N + + +I
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 207 LTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEG-LQNLVNLRELYLSHNGI 264
L NL++L + N+I L L L L + +N L + + L NL ++ L N +
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Query: 265 EVI 267
E +
Sbjct: 767 ECL 769
Score = 36.6 bits (83), Expect = 0.036
Identities = 74/288 (25%), Positives = 116/288 (40%), Gaps = 80/288 (27%)
Query: 105 LRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLT 164
LRQ L K ++ EL + D +E LE L I D++ + +LT
Sbjct: 416 LRQRLTKNAQDKLELHLFMLSGIPDTVFDLVE-LEVLKLELIPDVTIP-----PSIAQLT 469
Query: 165 RLKKLFLVNNKISKIEN--LSNLHQ-LQMLELGSNRIRAIEN-IDTLTNLESLFLGKNKI 220
LK+L+L + +KIE L+ L + L+ L + I+ I I +L LE L L N
Sbjct: 470 GLKELWLYHTA-AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN-- 526
Query: 221 TKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN-----------GIEVIEG 269
LS ++NR I+GL+ L L+ L L N G+ ++
Sbjct: 527 --------------LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVH-LQK 571
Query: 270 LENNNKLTMLDIASNRIKKIENISHLT-----------------ELQEFWMNDNLLESWS 312
L NN+ T L I N +KK+ N++ L LQE + DN L++
Sbjct: 572 LSINNEGTKL-IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIE 630
Query: 313 DL-----------------------DELKGARSLETVYLERNPLQKDP 337
++ ++ +LE +YL RN ++K P
Sbjct: 631 EIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP 678
>gi|187829877 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 73.6 bits (179), Expect = 3e-13
Identities = 74/236 (31%), Positives = 118/236 (50%), Gaps = 22/236 (9%)
Query: 91 IEGFEVLKKVKTLCLRQNLIKCIENLEEL-QSLRELDLYD--------NQIKKIENLEAL 141
I+G LK++K L L+ NL K + + ++ L++L + + N +KK+ N L
Sbjct: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMAN---L 593
Query: 142 TELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENL---SNLHQLQMLELGSNRI 198
TELE+ I +L R + L L+++ L +N + IE + +LH+L L+L N I
Sbjct: 594 TELEL--IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651
Query: 199 RAIE-NIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEG-LQNLVNLR 255
I I LTNLE L+L +NKI K+ L L L + N LT + + L NL+
Sbjct: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711
Query: 256 ELYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLE 309
L ++ N IE + L KL L + +N ++ + + LT L + + N LE
Sbjct: 712 NLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/183 (30%), Positives = 92/183 (50%), Gaps = 12/183 (6%)
Query: 97 LKKVKTLC----LRQNLIKCIENLEELQSLRELDLYDNQIKKIENL---EALTELEILDI 149
LKK+ L +R +L + ++ L +L+E+DL DN +K IE + + L L L +
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 150 SFNLLRNIE-GVDKLTRLKKLFLVNNKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDT 206
+N + I + LT L++L+L NKI KI L +L+ L+L N + + +I
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 207 LTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEG-LQNLVNLRELYLSHNGI 264
L NL++L + N+I L L L L + +N L + + L NL ++ L N +
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Query: 265 EVI 267
E +
Sbjct: 767 ECL 769
Score = 36.6 bits (83), Expect = 0.036
Identities = 74/288 (25%), Positives = 116/288 (40%), Gaps = 80/288 (27%)
Query: 105 LRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLT 164
LRQ L K ++ EL + D +E LE L I D++ + +LT
Sbjct: 416 LRQRLTKNAQDKLELHLFMLSGIPDTVFDLVE-LEVLKLELIPDVTIP-----PSIAQLT 469
Query: 165 RLKKLFLVNNKISKIEN--LSNLHQ-LQMLELGSNRIRAIEN-IDTLTNLESLFLGKNKI 220
LK+L+L + +KIE L+ L + L+ L + I+ I I +L LE L L N
Sbjct: 470 GLKELWLYHTA-AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN-- 526
Query: 221 TKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN-----------GIEVIEG 269
LS ++NR I+GL+ L L+ L L N G+ ++
Sbjct: 527 --------------LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVH-LQK 571
Query: 270 LENNNKLTMLDIASNRIKKIENISHLT-----------------ELQEFWMNDNLLESWS 312
L NN+ T L I N +KK+ N++ L LQE + DN L++
Sbjct: 572 LSINNEGTKL-IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIE 630
Query: 313 DL-----------------------DELKGARSLETVYLERNPLQKDP 337
++ ++ +LE +YL RN ++K P
Sbjct: 631 EIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP 678
>gi|187829871 leucine rich repeat containing 8 family, member A
[Homo sapiens]
Length = 810
Score = 73.6 bits (179), Expect = 3e-13
Identities = 74/236 (31%), Positives = 118/236 (50%), Gaps = 22/236 (9%)
Query: 91 IEGFEVLKKVKTLCLRQNLIKCIENLEEL-QSLRELDLYD--------NQIKKIENLEAL 141
I+G LK++K L L+ NL K + + ++ L++L + + N +KK+ N L
Sbjct: 537 IDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMAN---L 593
Query: 142 TELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENL---SNLHQLQMLELGSNRI 198
TELE+ I +L R + L L+++ L +N + IE + +LH+L L+L N I
Sbjct: 594 TELEL--IRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHI 651
Query: 199 RAIE-NIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEG-LQNLVNLR 255
I I LTNLE L+L +NKI K+ L L L + N LT + + L NL+
Sbjct: 652 AYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQ 711
Query: 256 ELYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLE 309
L ++ N IE + L KL L + +N ++ + + LT L + + N LE
Sbjct: 712 NLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLE 767
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/183 (30%), Positives = 92/183 (50%), Gaps = 12/183 (6%)
Query: 97 LKKVKTLC----LRQNLIKCIENLEELQSLRELDLYDNQIKKIENL---EALTELEILDI 149
LKK+ L +R +L + ++ L +L+E+DL DN +K IE + + L L L +
Sbjct: 587 LKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKL 646
Query: 150 SFNLLRNIE-GVDKLTRLKKLFLVNNKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDT 206
+N + I + LT L++L+L NKI KI L +L+ L+L N + + +I
Sbjct: 647 WYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGL 706
Query: 207 LTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEG-LQNLVNLRELYLSHNGI 264
L NL++L + N+I L L L L + +N L + + L NL ++ L N +
Sbjct: 707 LQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRL 766
Query: 265 EVI 267
E +
Sbjct: 767 ECL 769
Score = 36.6 bits (83), Expect = 0.036
Identities = 74/288 (25%), Positives = 116/288 (40%), Gaps = 80/288 (27%)
Query: 105 LRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLT 164
LRQ L K ++ EL + D +E LE L I D++ + +LT
Sbjct: 416 LRQRLTKNAQDKLELHLFMLSGIPDTVFDLVE-LEVLKLELIPDVTIP-----PSIAQLT 469
Query: 165 RLKKLFLVNNKISKIEN--LSNLHQ-LQMLELGSNRIRAIEN-IDTLTNLESLFLGKNKI 220
LK+L+L + +KIE L+ L + L+ L + I+ I I +L LE L L N
Sbjct: 470 GLKELWLYHTA-AKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGN-- 526
Query: 221 TKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN-----------GIEVIEG 269
LS ++NR I+GL+ L L+ L L N G+ ++
Sbjct: 527 --------------LSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVH-LQK 571
Query: 270 LENNNKLTMLDIASNRIKKIENISHLT-----------------ELQEFWMNDNLLESWS 312
L NN+ T L I N +KK+ N++ L LQE + DN L++
Sbjct: 572 LSINNEGTKL-IVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIE 630
Query: 313 DL-----------------------DELKGARSLETVYLERNPLQKDP 337
++ ++ +LE +YL RN ++K P
Sbjct: 631 EIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIP 678
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 72.8 bits (177), Expect = 5e-13
Identities = 79/274 (28%), Positives = 141/274 (51%), Gaps = 21/274 (7%)
Query: 79 EDVDLNHYRIGKIEGF-EVLKKVKTLCLRQNLIKCIENLEELQ---SLRELDLYDNQIKK 134
++V +N+ + +I F E + L L N+I I N + LQ +L LDL N I +
Sbjct: 100 QEVKMNYNELTEIPYFGEPTSNITLLSLVHNIIPEI-NAQALQFYPALESLDLSSNIISE 158
Query: 135 IENLE-ALTELEILDISFNLLRNIEG--VDKLTRLKKLFLVN-NKISKIE-NLSNLHQLQ 189
I+ +L+ L++S N + +E D L+ + +N N++S I + L LQ
Sbjct: 159 IKTSSFPRMQLKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQ 218
Query: 190 MLELGSNRIRAIENI--DTLTNLESLFLGKNKITKLQN--LDALTNLTVLSMQSNRLTKI 245
LEL NRI+ +E + L +L SL + +N I+KL++ L N+ L ++ N LT++
Sbjct: 219 FLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRV 278
Query: 246 E--GLQNLVNLRELYLSHNGIEVI--EGLENNNKLTMLDIASNRIKKIENISH--LTELQ 299
L L L++LY+S N IE I + E +L+ LD++ N++ +++ + L+ L+
Sbjct: 279 NKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLE 338
Query: 300 EFWMNDNLLESWSDLDELKGARSLETVYLERNPL 333
+ DN + +D + +L+T+ L N +
Sbjct: 339 RLNLGDNRVTHIAD-GVFRFLSNLQTLDLRNNEI 371
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 72.4 bits (176), Expect = 6e-13
Identities = 78/296 (26%), Positives = 139/296 (46%), Gaps = 44/296 (14%)
Query: 81 VDLNHYRIGKIE--GFEVLKKVKTLCLRQNLIKCIENLEELQS-LRELDLYDNQIKKIEN 137
++L++ ++ +I+ GFE L ++ + L N + + +L S + L L N+I+ +E
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEG 132
Query: 138 --LEALTELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKISKIE------------- 180
L+A LE+LD+S N + + +K+L L N+I +E
Sbjct: 133 SQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLLT 192
Query: 181 -------------NLSNLHQLQMLELGSNRIRAIENI--DTLTNLESLFLGKNKITKLQN 225
L +L L+L NRIR IE + L +LE L L +N I+KL +
Sbjct: 193 LRLSKNRITQLPVRAFKLPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKLTD 252
Query: 226 --LDALTNLTVLSMQSNRLTKIE--GLQNLVNLRELYLSHNGIEVI--EGLENNNKLTML 279
L+ + VL ++ N L ++ L L L +L+LS+N I I +G KL L
Sbjct: 253 GAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLHEL 312
Query: 280 DIASNRIKKI--ENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL 333
++ N + ++ E+++ L+ L ++ N + ++ KG RSL + L+ N +
Sbjct: 313 VLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAE-GAFKGLRSLRVLDLDHNEI 367
Score = 35.0 bits (79), Expect = 0.10
Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 35/150 (23%)
Query: 235 LSMQSNRLTKIE--GLQNLVNLRELYLS-----------------------HNGIEVIEG 269
L++ N+L++I+ G ++L NL+E+YL+ HN I +EG
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLQHNKIRSVEG 132
Query: 270 --LENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLLESWSDLDELKG-ARSLE 324
L+ L +LD++ N I ++ N H ++E + N + + +L G +RSL
Sbjct: 133 SQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGT-LELGAFDGLSRSLL 191
Query: 325 TVYLERNPLQKDPQYRRKVMLALPSVRQID 354
T+ L +N + + P K LP + Q+D
Sbjct: 192 TLRLSKNRITQLPVRAFK----LPRLTQLD 217
>gi|239752518 PREDICTED: similar to leucine rich repeat containing
50, partial [Homo sapiens]
Length = 489
Score = 71.2 bits (173), Expect = 1e-12
Identities = 36/125 (28%), Positives = 71/125 (56%)
Query: 230 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKI 289
+NL VL + N++TKIE + +L LR L L+ N + ++ L + LT L++ N+I +
Sbjct: 3 SNLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFV 62
Query: 290 ENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLALPS 349
++ +L LQ +++ N + S+ + L + SL + + NP+ ++ Y+ V+ +
Sbjct: 63 RDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQ 122
Query: 350 VRQID 354
+RQ+D
Sbjct: 123 LRQLD 127
Score = 62.0 bits (149), Expect = 8e-10
Identities = 34/93 (36%), Positives = 58/93 (62%)
Query: 121 SLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIE 180
+L LDL+ NQI KIEN+ L EL +L+++ N L +++ ++ L L +L L +N+I+ +
Sbjct: 4 NLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVR 63
Query: 181 NLSNLHQLQMLELGSNRIRAIENIDTLTNLESL 213
++ NL LQ L L N I + +++ L + SL
Sbjct: 64 DVDNLPCLQHLFLSFNNISSFDSVSCLADSSSL 96
Score = 61.6 bits (148), Expect = 1e-09
Identities = 38/124 (30%), Positives = 67/124 (54%), Gaps = 8/124 (6%)
Query: 142 TELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAI 201
+ L++LD+ N + IE ++ L L+ L L N +S ++NL+ L L L L N+I +
Sbjct: 3 SNLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFV 62
Query: 202 ENIDTLTNLESLFLGKNKITKLQNLDAL---TNLTVLSMQSNRLT-----KIEGLQNLVN 253
++D L L+ LFL N I+ ++ L ++L+ ++ N + K LQN++
Sbjct: 63 RDVDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQ 122
Query: 254 LREL 257
LR+L
Sbjct: 123 LRQL 126
Score = 61.2 bits (147), Expect = 1e-09
Identities = 44/158 (27%), Positives = 79/158 (50%), Gaps = 14/158 (8%)
Query: 188 LQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEG 247
L +L+L N+I IENI+ L L L L +N ++ + NL+ L +LT L+++ N++T +
Sbjct: 5 LDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD 64
Query: 248 LQNLVNLRELYLSHNGI---EVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMN 304
+ NL L+ L+LS N I + + L +++ L+ + N I QE W
Sbjct: 65 VDNLPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPI-----------AQESWYK 113
Query: 305 DNLLESWSDLDELKGARSLETVYLERNPLQKDPQYRRK 342
+L++ L +L R E + L K + +++
Sbjct: 114 HTVLQNMMQLRQLDMKRITEEERRMASVLAKKEEEKKR 151
Score = 51.6 bits (122), Expect = 1e-06
Identities = 37/121 (30%), Positives = 64/121 (52%), Gaps = 11/121 (9%)
Query: 81 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEA 140
+DL+ +I KIE L +++ L L +N + ++NL L SL EL+L NQI + +++
Sbjct: 8 LDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDN 67
Query: 141 LTELEILDISFNLLRNIEGVDKL---TRLKKLFLVNNKISK--------IENLSNLHQLQ 189
L L+ L +SFN + + + V L + L + N I++ ++N+ L QL
Sbjct: 68 LPCLQHLFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLD 127
Query: 190 M 190
M
Sbjct: 128 M 128
Score = 40.4 bits (93), Expect = 0.002
Identities = 24/61 (39%), Positives = 35/61 (57%), Gaps = 3/61 (4%)
Query: 273 NNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNP 332
++ L +LD+ N+I KIENI+HL EL+ + N L S +D L G SL + L N
Sbjct: 2 SSNLDVLDLHGNQITKIENINHLCELRVLNLARNFL---SHVDNLNGLDSLTELNLRHNQ 58
Query: 333 L 333
+
Sbjct: 59 I 59
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 71.2 bits (173), Expect = 1e-12
Identities = 74/250 (29%), Positives = 122/250 (48%), Gaps = 24/250 (9%)
Query: 101 KTLCLRQNLIKCIENLEELQSLRELDLYDNQIK--KIENLEALTELEILDISFNLLRNIE 158
K +C+R+NL + + + + R L+L++NQI+ K+ + + L LEIL +S N +R IE
Sbjct: 59 KVICVRKNLREVPDGIS--TNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIE 116
Query: 159 --GVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRIRAIEN--IDTLTNLES 212
+ L L L L +N+++ I N L +L+ L L +N I +I + + + +L
Sbjct: 117 IGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRR 176
Query: 213 LFLGKNKITKLQN---LDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVI-- 267
L LG+ K + + L+NL L++ L +I L L+ L EL LS N + I
Sbjct: 177 LDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRP 236
Query: 268 ---EGLENNNKLTMLDIASNRIKK--IENISHLTELQEFWMNDNLLESWSDLDELKGARS 322
+GL + KL M+ I++ +N+ L E+ N LL D
Sbjct: 237 GSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPH----DLFTPLHH 292
Query: 323 LETVYLERNP 332
LE ++L NP
Sbjct: 293 LERIHLHHNP 302
Score = 33.1 bits (74), Expect = 0.40
Identities = 31/109 (28%), Positives = 53/109 (48%), Gaps = 6/109 (5%)
Query: 94 FEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIE--NLEALTELEILDISF 151
FE L ++ L L ++ I NL L L ELDL N + I + + L L+ L +
Sbjct: 193 FEGLSNLRYLNLAMCNLREIPNLTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQ 252
Query: 152 NLLRNIE--GVDKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSN 196
+ ++ IE D L L ++ L +N ++ + + + LH L+ + L N
Sbjct: 253 SQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLHHN 301
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 70.5 bits (171), Expect = 2e-12
Identities = 71/279 (25%), Positives = 134/279 (48%), Gaps = 31/279 (11%)
Query: 67 VDMETINLDRDAEDVDLNHYRIGKI--EGFEVLKKVKTLCLRQNLIKCIENLEELQSLRE 124
V E N +R E++ L+ +I ++ + F K +L + L +L+E
Sbjct: 37 VPKEVFNFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKE 96
Query: 125 LDLYDNQIKKI-ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVNNKISKIE-N 181
LD+ N +++ EN++ L I++ S N + + +G +L L +L+L + + + N
Sbjct: 97 LDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPAN 156
Query: 182 LSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSN 240
L +L++LEL N ++ + +++ L LE L LG N+ +L
Sbjct: 157 FGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELP---------------- 200
Query: 241 RLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNK-LTMLDIASNRIKKIE-NISHLTEL 298
E L + NLREL++ +N ++V+ G K L LD++ NRI+ ++ +IS L
Sbjct: 201 -----EVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEAL 255
Query: 299 QEFWMNDNLLESWSDLDELKGARSLETVYLERNPLQKDP 337
++ ++ N+L+ D L + L T+ ++ N L P
Sbjct: 256 EDLLLSSNMLQQLPDSIGL--LKKLTTLKVDDNQLTMLP 292
Score = 62.0 bits (149), Expect = 8e-10
Identities = 54/236 (22%), Positives = 124/236 (52%), Gaps = 29/236 (12%)
Query: 79 EDVDLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCIE-NLEELQSLRELDLYDNQIKKIE 136
E +DL + G++ E + ++ ++ L + N ++ + ++ +L+ L LD+ N+I+ ++
Sbjct: 187 ERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVD 246
Query: 137 -NLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVNNKISKIEN-LSNLHQLQMLEL 193
++ LE L +S N+L+ + + + L +L L + +N+++ + N + NL L+ +
Sbjct: 247 MDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDC 306
Query: 194 GSNRIRAIEN-IDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEGLQNL 251
N + ++ + I L +L +L + +N + +L + + + N+TV+S++SN+L +
Sbjct: 307 SCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLP----- 361
Query: 252 VNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIE-NISHLTELQEFWMNDN 306
E + KL +L+++ NR+K + + + L EL W++DN
Sbjct: 362 ----------------EEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 401
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 70.1 bits (170), Expect = 3e-12
Identities = 71/255 (27%), Positives = 129/255 (50%), Gaps = 35/255 (13%)
Query: 115 NLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLV 172
++ L +LRELD+ N I++ EN++ L I++ S N + + +G +L L +L+L
Sbjct: 87 SIANLINLRELDVSKNGIQEFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLN 146
Query: 173 NNKISKIE-NLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDAL 229
+ + + N L +LQ+LEL N+++ + + ++ LT LE L LG N+ T++ L+ L
Sbjct: 147 DAFLEFLPANFGRLTKLQILELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQL 206
Query: 230 TNLTVLSMQSNRLTKI------------------------EGLQNLVNLRELYLSHNGIE 265
+ L M +NRLT I EG+ NL++L LS N ++
Sbjct: 207 SGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQ 266
Query: 266 VI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLESW-SDLDELKGARS 322
+ E + + +T L I N++ + ++I L ++E + N +E+ S + +L +
Sbjct: 267 QLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQL---TN 323
Query: 323 LETVYLERNPLQKDP 337
L T + N LQ+ P
Sbjct: 324 LRTFAADHNYLQQLP 338
Score = 56.2 bits (134), Expect = 4e-08
Identities = 40/104 (38%), Positives = 61/104 (58%), Gaps = 4/104 (3%)
Query: 210 LESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEG-LQNLVNLRELYLSHNGI-EV 266
LE L+L N+I +L + L +L LS+ N LT + + NL+NLREL +S NGI E
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 267 IEGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDNLLE 309
E ++N LT+++ + N I K+ + S L L + ++ND LE
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLE 151
Score = 55.8 bits (133), Expect = 6e-08
Identities = 51/172 (29%), Positives = 85/172 (49%), Gaps = 29/172 (16%)
Query: 166 LKKLFLVNNKISKI-ENLSNLHQLQMLELGSNRIRAIE-NIDTLTNLESLFLGKNKITKL 223
L++L+L N+I ++ + L N L L L N + + +I L NL L + KN I +
Sbjct: 48 LEELYLDANQIEELPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEF 107
Query: 224 -QNLDALTNLTVLSMQSNRLTKI-EGLQNLVNLRELYLSHNGIE-------------VIE 268
+N+ LT++ N ++K+ +G L+NL +LYL+ +E ++E
Sbjct: 108 PENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILE 167
Query: 269 GLENN--------NKLTML---DIASNRIKKI-ENISHLTELQEFWMNDNLL 308
EN N+LT L D+ SN ++ E + L+ L+EFWM+ N L
Sbjct: 168 LRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRL 219
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.133 0.355
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,559,242
Number of Sequences: 37866
Number of extensions: 502709
Number of successful extensions: 4977
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 129
Number of HSP's successfully gapped in prelim test: 318
Number of HSP's that attempted gapping in prelim test: 3093
Number of HSP's gapped (non-prelim): 1389
length of query: 360
length of database: 18,247,518
effective HSP length: 103
effective length of query: 257
effective length of database: 14,347,320
effective search space: 3687261240
effective search space used: 3687261240
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.