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Search of human proteins with 12758125
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12758125 ribosomal RNA processing 8, methyltransferase,
homolog [Homo sapiens]
(456 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12758125 ribosomal RNA processing 8, methyltransferase, homol... 925 0.0
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens] 47 4e-05
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 45 1e-04
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 45 1e-04
gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens] 43 5e-04
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 42 9e-04
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 42 9e-04
gi|168229156 NFKB activating protein [Homo sapiens] 41 0.002
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 41 0.003
gi|42476169 Paf1, RNA polymerase II associated factor, homolog [... 41 0.003
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 41 0.003
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 40 0.003
gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e... 40 0.003
gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d... 40 0.003
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 40 0.003
gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a ... 40 0.003
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 40 0.003
gi|23111062 splicing factor, arginine/serine-rich 8 [Homo sapiens] 40 0.004
gi|178557734 microtubule-associated protein tau isoform 6 [Homo ... 40 0.006
gi|38492356 DNA-directed DNA polymerase delta 3 [Homo sapiens] 40 0.006
gi|38488727 arginine/serine-rich coiled-coil 1 [Homo sapiens] 40 0.006
gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo sapi... 40 0.006
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 39 0.007
gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax ... 39 0.010
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 39 0.010
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 39 0.010
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 39 0.010
gi|156564398 target of EGR1, member 1 (nuclear) [Homo sapiens] 39 0.010
gi|22748973 protein interacting with cyclin A1 [Homo sapiens] 39 0.013
gi|153251913 hypothetical protein LOC57604 isoform 1 [Homo sapiens] 39 0.013
>gi|12758125 ribosomal RNA processing 8, methyltransferase, homolog
[Homo sapiens]
Length = 456
Score = 925 bits (2391), Expect = 0.0
Identities = 456/456 (100%), Positives = 456/456 (100%)
Query: 1 MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLC 60
MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLC
Sbjct: 1 MFEEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLC 60
Query: 61 ISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQA 120
ISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQA
Sbjct: 61 ISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQA 120
Query: 121 LVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPP 180
LVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPP
Sbjct: 121 LVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPP 180
Query: 181 HTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRA 240
HTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRA
Sbjct: 181 HTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRA 240
Query: 241 RMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIA 300
RMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIA
Sbjct: 241 RMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDPEAFLLYHRGFQSQVKKWPLQPVDRIA 300
Query: 301 RDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVA 360
RDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVA
Sbjct: 301 RDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRVTVCDMAQVPLEDESVDVA 360
Query: 361 VFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLT 420
VFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLT
Sbjct: 361 VFCLSLMGTNIRDFLEEANRVLKPGGLLKVAEVSSRFEDVRTFLRAVTKLGFKIVSKDLT 420
Query: 421 NSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR 456
NSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR
Sbjct: 421 NSHFFLFDFQKTGPPLVGPKAQLSGLQLQPCLYKRR 456
>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
Length = 484
Score = 47.0 bits (110), Expect = 4e-05
Identities = 52/219 (23%), Positives = 87/219 (39%), Gaps = 22/219 (10%)
Query: 26 PAASSQNKGSKRRQLLATLRALE------AASLSQHPPSLCISDSEEEEEERKKKCPKKA 79
P A+ ++ QLL + ++ AA L PSL S +E EE K+ +
Sbjct: 173 PGANLNSQSLAADQLLKLMSTVDPKLNHVAAGLVS--PSLKSDTSSKEIEEAMKRVREAQ 230
Query: 80 SFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKH 139
S SA+ E KK +K+ + S S H+++ S K + + +
Sbjct: 231 SLISAAIEPDKKEEKRRHSRSR--SRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSK 288
Query: 140 APINSAQHLDNVDQTGPKAWKGSTTNDPPKQSP----GSTSPKPPHTLSRKQWRNRQKNK 195
+P H + G ++ S T D K+ T PK T R + +R++ +
Sbjct: 289 SPRRRRSHSR---ERGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRR 345
Query: 196 RRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEAR 234
RR ++ + P+ P +P K SP PR E +
Sbjct: 346 RRSRSGTRSPKKP-----RSPKRKLSRSPSPRRHKKEKK 379
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/190 (25%), Positives = 71/190 (37%), Gaps = 21/190 (11%)
Query: 48 EAASLSQHPPSLCISDSEEEEEER---KKKCPKKASFASASAEVGKKGKKKCQKQGPPCS 104
+AAS S S SD EEE+ KK PKK A A + +K S
Sbjct: 213 KAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSS 272
Query: 105 DSEEEVER--KKKCHKQALVGSDSAEDEKR-------KRKCQKHAPINSAQHLDNVDQTG 155
D EEE ++ K K + V SA K+ K+ +K P+ S++ + +
Sbjct: 273 DEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSS 332
Query: 156 PKAWK---------GSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQ 206
+ K +TT PP + +S + S + K KN P
Sbjct: 333 SEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNSSNKPA 392
Query: 207 VPDQAPAEAP 216
V ++PA P
Sbjct: 393 VTTKSPAVKP 402
Score = 41.6 bits (96), Expect = 0.002
Identities = 44/181 (24%), Positives = 76/181 (41%), Gaps = 17/181 (9%)
Query: 22 SRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASF 81
S AA++ K ++Q++A A + ++ S S S+EEEE++K K +
Sbjct: 230 SEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPY 289
Query: 82 ASA---SAEVGKKG------KKKCQKQGP------PCSDSEEEVERKKKCHKQALVGSDS 126
+S SA KK KK +KQ P +S+ E +KK +A+V +
Sbjct: 290 SSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKAT 349
Query: 127 AEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRK 186
+ K+ + + +S+ + D P G+T N K + + SP + K
Sbjct: 350 TKPPPAKKAAESSS--DSSDSDSSEDDEAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPK 407
Query: 187 Q 187
Q
Sbjct: 408 Q 408
Score = 40.0 bits (92), Expect = 0.004
Identities = 60/251 (23%), Positives = 87/251 (34%), Gaps = 41/251 (16%)
Query: 4 EPEWAEAAPVAAGLGPVISRPPPAASSQNKGS-----KRRQLLAT------------LRA 46
+P A PV G +++R ++SS+ + S K ++++AT L A
Sbjct: 401 KPAAAPKQPVGGGQ-KLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPA 459
Query: 47 LEAASLSQHPPSLCISDSEEEEEERK-----KKCPKKASFASASAEVGKKGKKKCQKQGP 101
+A S+ S S S EEEEE+ KK P+K + +A ++ K K +
Sbjct: 460 KQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNS 519
Query: 102 PCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKG 161
SD E E+EK K K A + KA K
Sbjct: 520 SSSDDSSE-----------------EEEEKLKGKGSPRPQAPKANGTSALTAQNGKAAKN 562
Query: 162 STTNDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTE 221
S + K+ K RKQ K + K Q P+ P EK
Sbjct: 563 SEEEEEEKKKAAVVVSKSGSLKKRKQ-NEAAKEAETPQAKKIKLQTPNTFPKRKKGEKRA 621
Query: 222 VSPVPRTDSHE 232
SP R E
Sbjct: 622 SSPFRRVREEE 632
Score = 34.3 bits (77), Expect = 0.24
Identities = 61/275 (22%), Positives = 90/275 (32%), Gaps = 40/275 (14%)
Query: 4 EPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISD 63
+ E + P+ GP S PPP+A K + + + S+ SD
Sbjct: 273 DEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPVESSEDS-----SD 327
Query: 64 SEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKK-------- 115
+ E +KK P KA + A+ + K SDS E+ E K
Sbjct: 328 ESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSKPAGTTKNS 387
Query: 116 -----------------CHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDN--VDQTGP 156
KQ + G K + +S + V T P
Sbjct: 388 SNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKKMVATTKP 447
Query: 157 KAWKGSTTNDPPKQSP-GSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQA---- 211
KA + + P KQ+P GS S + + +K K K P +V A
Sbjct: 448 KATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTSKSAVKKK--PQKVAGGAAPSK 505
Query: 212 PAEAPTEKTEVSPVPRT-DSHEARAGALRARMAQR 245
PA A K E S + DS E L+ + + R
Sbjct: 506 PASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPR 540
Score = 32.0 bits (71), Expect = 1.2
Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 18/188 (9%)
Query: 63 DSEEEEEERKKKCPKKASFASASAEV--GKKGKKKCQKQGPPCS--DSEEEVERKKKCHK 118
DS EEEEE + KKA+ + + GK K + S D +EE ++K+ K
Sbjct: 89 DSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQKKQPVQK 148
Query: 119 QALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQ---TGPKAWKGSTTNDP------PK 169
+ +A+ +K K +S++ +Q P K T P PK
Sbjct: 149 GVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQTKAPPKPARAAPK 208
Query: 170 QSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPP--QVPDQAPAEA---PTEKTEVSP 224
+ G + + S + ++ K K P QV +AP +A PT K+ S
Sbjct: 209 IANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE 268
Query: 225 VPRTDSHE 232
+D E
Sbjct: 269 DSSSDEEE 276
Score = 29.6 bits (65), Expect = 5.9
Identities = 42/193 (21%), Positives = 66/193 (34%), Gaps = 16/193 (8%)
Query: 48 EAASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSE 107
+AA+ + S S +++EE++KK+ +K A A K K S +
Sbjct: 118 KAAAKASESSSSEESSDDDDEEDQKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSED 177
Query: 108 EEVERKKKCHKQALVGSDSAEDEKRKRKCQKHA-------PINSAQHLDNVDQTGPKAWK 160
E + +K V + + K R K A +S+ + D KA
Sbjct: 178 EPPKNQKPKITPVTVKAQTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAA 237
Query: 161 GSTTNDPPKQSPGSTSPKPPHTLSRKQWRN-------RQKNKRRCKNKFQPPQVPDQAPA 213
P KQ K T +RK + ++ K+ KNK P P
Sbjct: 238 TPKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNK--PGPYSSVPPP 295
Query: 214 EAPTEKTEVSPVP 226
AP K + P
Sbjct: 296 SAPPPKKSLGTQP 308
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 45.4 bits (106), Expect = 1e-04
Identities = 48/252 (19%), Positives = 86/252 (34%), Gaps = 24/252 (9%)
Query: 5 PEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDS 64
PE P P +S P PA S++ +R + S P + S
Sbjct: 1714 PETRSRTPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRS 1773
Query: 65 EEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKK----CHKQA 120
K + ++ + +S ++ ++ S S V R+++ H ++
Sbjct: 1774 RSRSRREKTRTTRRRDRSGSSQSTSRRRQR---------SRSRSRVTRRRRGGSGYHSRS 1824
Query: 121 LVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPP 180
+S+ R+R+ + P S + + +T P WK S + P S S P
Sbjct: 1825 PARQESSRTSSRRRRGRSRTPPTSRKR--SRSRTSPAPWKRSRSRASPATHRRSRSRTPL 1882
Query: 181 HTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRA 240
+ R + R ++RR +++ ++ SPV R S R
Sbjct: 1883 ISRRRSRSRTSPVSRRRSRSR---------TSVTRRRSRSRASPVSRRRSRSRTPPVTRR 1933
Query: 241 RMAQRLDGARFR 252
R R R R
Sbjct: 1934 RSRSRTPTTRRR 1945
Score = 38.1 bits (87), Expect = 0.017
Identities = 44/218 (20%), Positives = 80/218 (36%), Gaps = 23/218 (10%)
Query: 24 PPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASFAS 83
P P + ++K KR++ R+ A S+ +DS + + + A+
Sbjct: 232 PTPKSKRKSKDKKRKRS----RSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAAKTH 287
Query: 84 ASAEVGKKGKKKCQKQGP---PCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHA 140
+A G+ ++G P S+ ++ + A S ++K K K +K A
Sbjct: 288 TTALAGRSPSPASGRRGEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDKKEKSA 347
Query: 141 PINSAQHLDNVDQTGPKAWKGSTTNDPPKQSP-----GSTSPKPPHTLSRKQWRNRQKNK 195
+ P + ST +PP +P SP+P T Q ++
Sbjct: 348 T-----------RPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSE 396
Query: 196 RRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEA 233
PP+ P++ P + +E + SP P S A
Sbjct: 397 ASPTRDRSPPKSPEKLPQSSSSESSPPSPQPTKVSRHA 434
Score = 37.0 bits (84), Expect = 0.037
Identities = 48/232 (20%), Positives = 77/232 (33%), Gaps = 28/232 (12%)
Query: 22 SRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASF 81
SR P S S+RR+ S+ PP+ S + R P K S
Sbjct: 1822 SRSPARQESSRTSSRRRR-----------GRSRTPPT-----SRKRSRSRTSPAPWKRSR 1865
Query: 82 ASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALV----GSDSAEDEKRKRKCQ 137
+ AS ++ + + S S +++ + V A R+R
Sbjct: 1866 SRASPATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRS 1925
Query: 138 KHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRR 197
+ P+ + P + S + PP S S PP T R + R +RR
Sbjct: 1926 RTPPVTRRRSRSRT----PTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRR 1981
Query: 198 CKNKFQP----PQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGALRARMAQR 245
+++ P +P ++ SPV R S A+R R R
Sbjct: 1982 SRSRTSPVTRRRSRSRTSPVTRRRSRSRTSPVTRRRSRSRTPPAIRRRSRSR 2033
Score = 35.0 bits (79), Expect = 0.14
Identities = 61/284 (21%), Positives = 96/284 (33%), Gaps = 45/284 (15%)
Query: 22 SRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASF 81
SR P S+R+ T + ++ S IS R P+ +
Sbjct: 715 SRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISS----RRSRSLSSPRSKAK 770
Query: 82 ASASAEVGKKGKKKCQKQG----PPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQ 137
+ S G C KQ P S S + K S S+ K+K K
Sbjct: 771 SRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKTP 830
Query: 138 K---------HAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQW 188
H + S T P+A + S T P ++S +SP P +
Sbjct: 831 SRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVT--PQRRSCFESSPDP-------EL 881
Query: 189 RNRQKNKRRCKNKFQPPQV-----PDQAPAEAPTEKTEVSPV--PRTDSHE--------- 232
++R ++ C PP+V P Q+P+ + + + +V + PR SH
Sbjct: 882 KSRTPSRHSCSGS-SPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSR 940
Query: 233 --ARAGALRARMAQRLDGARFRYLNEQLYSGPSSAAQRLFQEDP 274
+R R+R R L +SG SS ++ E P
Sbjct: 941 VTSRTTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETP 984
Score = 32.3 bits (72), Expect = 0.91
Identities = 46/216 (21%), Positives = 87/216 (40%), Gaps = 31/216 (14%)
Query: 44 LRALEAASLSQHPPSL------------CISDSEEEEE---ERKKKCPKKASFASASAE- 87
LR LEAA + + P + C+ E EE E ++ K A+F E
Sbjct: 42 LRRLEAALVKRPNPDILDHERKRRVELRCLELEEMMEEQGYEEQQIQEKVATFRLMLLEK 101
Query: 88 -VGKKGKKKCQKQGPPCSDSEE--EVERKKKCHKQALVG-SDSAED------EKRKRKCQ 137
V GK++ Q P +++ + E+ KK +A G SDS D ++R R+ +
Sbjct: 102 DVNPGGKEETPGQRPAVTETHQLAELNEKKNERLRAAFGISDSYVDGSSFDPQRRAREAK 161
Query: 138 KHAP-----INSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQ 192
+ AP + + + PK K D ++S S+ + S+K+ +
Sbjct: 162 QPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSE 221
Query: 193 KNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRT 228
++ K++ P+ ++ + +P P++
Sbjct: 222 SESKKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKS 257
Score = 32.3 bits (72), Expect = 0.91
Identities = 33/140 (23%), Positives = 52/140 (37%), Gaps = 18/140 (12%)
Query: 63 DSEEEEEERKKKCPK--------KASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKK 114
D + E K+ P+ + S +S S +K KKK + +G S ERKK
Sbjct: 152 DPQRRAREAKQPAPEPPKPYSLVRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKK 211
Query: 115 KCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGS 174
K+ +E E +KRK + P + + D K + +T PK
Sbjct: 212 SSKKK----KHRSESESKKRKHRSPTPKSKRKSKDK------KRKRSRSTTPAPKSRRAH 261
Query: 175 TSPKPPHTLSRKQWRNRQKN 194
S S R+R ++
Sbjct: 262 RSTSADSASSSDTSRSRSRS 281
Score = 29.6 bits (65), Expect = 5.9
Identities = 36/190 (18%), Positives = 76/190 (40%), Gaps = 8/190 (4%)
Query: 62 SDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQAL 121
S+S +++ + + S + +S E+ K Q++ S + + + + +++
Sbjct: 1519 SESSVDQKTVARTPLGQRSRSGSSQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSR 1578
Query: 122 VGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPH 181
GS S E + + R + + S+ + + + P+A GS ++ PK P+
Sbjct: 1579 SGS-SPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSR 1637
Query: 182 TLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPA-----EAPTEKTEVSPVPRTDSHEARAG 236
+ S + R + + P P A +P KT+ PR S +
Sbjct: 1638 SGSSSKGRG-PSPEGSSSTESSPEHPPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPE 1696
Query: 237 ALR-ARMAQR 245
R AR+++R
Sbjct: 1697 LTRKARLSRR 1706
>gi|42542379 serine/arginine repetitive matrix 1 [Homo sapiens]
Length = 904
Score = 43.1 bits (100), Expect = 5e-04
Identities = 44/208 (21%), Positives = 82/208 (39%), Gaps = 9/208 (4%)
Query: 23 RPPPAASSQNKGSKRRQLLATL-RALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASF 81
+PP SS + ++R A+ R S PP ++ R +K S
Sbjct: 373 KPPKRTSSPPRKTRRLSPSASPPRRRHRPSPPATPPPKTRHSPTPQQSNRTRKSRVSVSP 432
Query: 82 ASASAEVGK-KGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHA 140
S +V K KG +K + P + E+ ++ + +DS + ++ R+ + +
Sbjct: 433 GRTSGKVTKHKGTEKRESPSPAPKPRKVELSESEEDKGGKMAAADSVQQRRQYRRQNQQS 492
Query: 141 PINSAQHLDNVDQTGPKAW-KGSTTNDPPKQSPG-STSPKPPHTLSRKQWRNRQKNKRRC 198
+S + D+ ++ K + SP S SP P RK+ + RR
Sbjct: 493 SSDSGSSSSSEDERPKRSHVKNGEVGRRRRHSPSRSASPSP-----RKRQKETSPRGRRR 547
Query: 199 KNKFQPPQVPDQAPAEAPTEKTEVSPVP 226
++ PP ++P+ AP + +P P
Sbjct: 548 RSPSPPPTRRRRSPSPAPPPRRRRTPTP 575
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 42.4 bits (98), Expect = 9e-04
Identities = 49/234 (20%), Positives = 93/234 (39%), Gaps = 29/234 (12%)
Query: 31 QNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERK----KKCPKKASFASASA 86
+++ S+ + L + A S+ + EE E E + KK P KA+
Sbjct: 463 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE 522
Query: 87 EVGKKGKKKCQKQ-----------------GPPCSDSEEEVERKKKCHKQALVGSDSAED 129
E G+K +++ Q++ SE+E +++ +A + AE
Sbjct: 523 EEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEA 582
Query: 130 EKRKRKCQKHAPINSAQHL-DNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQW 188
++ K+ +K + + + L + P+ K P ++ S PK P + K
Sbjct: 583 KEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP--VEEKGK 640
Query: 189 RNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEV-----SPVPRTDSHEARAGA 237
K+ K K P+ P + ++P K+ V SPVP++ EA++ A
Sbjct: 641 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKA 694
Score = 34.7 bits (78), Expect = 0.18
Identities = 51/221 (23%), Positives = 89/221 (40%), Gaps = 23/221 (10%)
Query: 18 GPVIS-RPPPAASSQNKGSKRRQLLATLRALEAASLS-QHPPSLCISDSEEEEEERKKKC 75
GP+ + RPP SS+ + K +EA L QH I + + E+E+ +
Sbjct: 421 GPLYTHRPPITISSKIQKPK----------VEAPKLKVQHKFVEEIIEETKVEDEKSEME 470
Query: 76 PKKASFASASAEVGKKGKKKC--QKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRK 133
+ A K+ KK+ +K+ P ++ EEEV KK K E EK +
Sbjct: 471 EALTAITEELAVSMKEEKKEAAEEKEEEPEAE-EEEVAAKKSPVKATAPEVKEEEGEKEE 529
Query: 134 RKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQK 193
+ Q+ + + G +GS+ + +Q G T + + K
Sbjct: 530 EEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE------AEGEEAEAK 583
Query: 194 NKRRCKNKFQPPQVPDQAPAEAPTEKTE--VSPVPRTDSHE 232
+++ + K + ++ A+A EK E SPVP++ E
Sbjct: 584 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE 624
Score = 33.5 bits (75), Expect = 0.41
Identities = 54/252 (21%), Positives = 93/252 (36%), Gaps = 31/252 (12%)
Query: 3 EEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCIS 62
EEPE AE VAA PV + P + + + E A Q
Sbjct: 497 EEPE-AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 555
Query: 63 DSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKK--KCHKQA 120
+ E+EE +++ + + A E K +KK +++ + EE V K K K
Sbjct: 556 EGSSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 614
Query: 121 LVGSDSAEDEKRKRKCQKH-------APINSAQHLDNVDQTGPKA-----WKGSTTNDPP 168
S +EK K K +P+ + + PK+ K + P
Sbjct: 615 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 674
Query: 169 KQSPGSTSPKPPHTLSR---------------KQWRNRQKNKRRCKNKFQPPQVPDQAPA 213
++ S PK P ++ K+ + K ++ K + +P VP++ A
Sbjct: 675 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 734
Query: 214 EAPTEKTEVSPV 225
E+P ++ V+ V
Sbjct: 735 ESPVKEEAVAEV 746
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 42.4 bits (98), Expect = 9e-04
Identities = 49/234 (20%), Positives = 93/234 (39%), Gaps = 29/234 (12%)
Query: 31 QNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERK----KKCPKKASFASASA 86
+++ S+ + L + A S+ + EE E E + KK P KA+
Sbjct: 87 EDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKE 146
Query: 87 EVGKKGKKKCQKQ-----------------GPPCSDSEEEVERKKKCHKQALVGSDSAED 129
E G+K +++ Q++ SE+E +++ +A + AE
Sbjct: 147 EEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEA 206
Query: 130 EKRKRKCQKHAPINSAQHL-DNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQW 188
++ K+ +K + + + L + P+ K P ++ S PK P + K
Sbjct: 207 KEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSP--VEEKGK 264
Query: 189 RNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEV-----SPVPRTDSHEARAGA 237
K+ K K P+ P + ++P K+ V SPVP++ EA++ A
Sbjct: 265 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKA 318
Score = 34.7 bits (78), Expect = 0.18
Identities = 51/221 (23%), Positives = 89/221 (40%), Gaps = 23/221 (10%)
Query: 18 GPVIS-RPPPAASSQNKGSKRRQLLATLRALEAASLS-QHPPSLCISDSEEEEEERKKKC 75
GP+ + RPP SS+ + K +EA L QH I + + E+E+ +
Sbjct: 45 GPLYTHRPPITISSKIQKPK----------VEAPKLKVQHKFVEEIIEETKVEDEKSEME 94
Query: 76 PKKASFASASAEVGKKGKKKC--QKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRK 133
+ A K+ KK+ +K+ P ++ EEEV KK K E EK +
Sbjct: 95 EALTAITEELAVSMKEEKKEAAEEKEEEPEAE-EEEVAAKKSPVKATAPEVKEEEGEKEE 153
Query: 134 RKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQK 193
+ Q+ + + G +GS+ + +Q G T + + K
Sbjct: 154 EEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAE------AEGEEAEAK 207
Query: 194 NKRRCKNKFQPPQVPDQAPAEAPTEKTE--VSPVPRTDSHE 232
+++ + K + ++ A+A EK E SPVP++ E
Sbjct: 208 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEE 248
Score = 33.5 bits (75), Expect = 0.41
Identities = 54/252 (21%), Positives = 93/252 (36%), Gaps = 31/252 (12%)
Query: 3 EEPEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCIS 62
EEPE AE VAA PV + P + + + E A Q
Sbjct: 121 EEPE-AEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
Query: 63 DSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKK--KCHKQA 120
+ E+EE +++ + + A E K +KK +++ + EE V K K K
Sbjct: 180 EGSSEKEEGEQEEGETEAEAEGE-EAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 238
Query: 121 LVGSDSAEDEKRKRKCQKH-------APINSAQHLDNVDQTGPKA-----WKGSTTNDPP 168
S +EK K K +P+ + + PK+ K + P
Sbjct: 239 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPV 298
Query: 169 KQSPGSTSPKPPHTLSR---------------KQWRNRQKNKRRCKNKFQPPQVPDQAPA 213
++ S PK P ++ K+ + K ++ K + +P VP++ A
Sbjct: 299 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358
Query: 214 EAPTEKTEVSPV 225
E+P ++ V+ V
Sbjct: 359 ESPVKEEAVAEV 370
>gi|168229156 NFKB activating protein [Homo sapiens]
Length = 415
Score = 41.2 bits (95), Expect = 0.002
Identities = 44/176 (25%), Positives = 71/176 (40%), Gaps = 28/176 (15%)
Query: 29 SSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEE----EEEERKKKCPKKASFASA 84
S + K R+ + L A E LS P DS+E E+EE KK ++
Sbjct: 125 SLRQKRLSERERIGELGAPEVWGLSPKNPE---PDSDEHTPVEDEEPKK--------STT 173
Query: 85 SAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDS-------AEDEKRKRKCQ 137
SA ++ KKK + S + + K+ HK+ SDS + DE KR+ +
Sbjct: 174 SASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDEDNKRRAK 233
Query: 138 KHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSRKQWRNRQK 193
K A+ + + K +K + K+S S+S + W++R K
Sbjct: 234 K------AKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLENPWKDRTK 283
Score = 37.7 bits (86), Expect = 0.022
Identities = 31/132 (23%), Positives = 52/132 (39%), Gaps = 7/132 (5%)
Query: 54 QHPPSLCISDSEEEEEERKKKC-PKKASFASASAEVGKKGKKKCQKQGPPCSDSE----- 107
+ P S S EEE++KK K+ S + K+ KK + SDSE
Sbjct: 166 EEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSD 225
Query: 108 -EEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTND 166
+ R KK K+ ++ K+KR + + + ++ ++ WK T +
Sbjct: 226 EDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEFLENPWKDRTKAE 285
Query: 167 PPKQSPGSTSPK 178
P G +PK
Sbjct: 286 EPSDLIGPEAPK 297
Score = 31.2 bits (69), Expect = 2.0
Identities = 23/87 (26%), Positives = 40/87 (45%), Gaps = 2/87 (2%)
Query: 27 AASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASFAS--A 84
++ S+ + KRR+ ++ R + S S +DS +E+ +R+ K KK
Sbjct: 186 SSRSKERSKKRRKKKSSKRKHKKYSEDSDSDSDSETDSSDEDNKRRAKKAKKKEKKKKHR 245
Query: 85 SAEVGKKGKKKCQKQGPPCSDSEEEVE 111
S + KK KK +K+ S E + E
Sbjct: 246 SKKYKKKRSKKSRKESSDSSSKESQEE 272
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 40.8 bits (94), Expect = 0.003
Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 20/142 (14%)
Query: 12 PVAAGLGPVISRPPPAASSQNKGSK-------RRQLLATLRALEAASLSQHPPSLC-ISD 63
P G P RPP ++SS + + +R+ A R LEA + L + +
Sbjct: 285 PKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLRE 344
Query: 64 SEEEEEERKKKCPKKASFASASA-----------EVGKKGKKKCQKQGPPCS-DSEEEVE 111
E+EE+ER+++ + S E KK +K + +GPP S DSE E E
Sbjct: 345 QEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAE 404
Query: 112 RKKKCHKQALVGSDSAEDEKRK 133
+++ K A S+ + RK
Sbjct: 405 LEREAKKSAKKPQSSSTEPARK 426
Score = 31.2 bits (69), Expect = 2.0
Identities = 44/192 (22%), Positives = 70/192 (36%), Gaps = 38/192 (19%)
Query: 29 SSQNKGSKRR----QLLATLRA------LEAASLSQHPPSLCISDSEEEEEERKKKCPKK 78
SS N G KR+ ++ + RA L+ AS+S S SE E+ + P+K
Sbjct: 149 SSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEK 208
Query: 79 ASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQK 138
+ A G+KK + SDS+ + SD A+ E
Sbjct: 209 KAAVRAPRRGPLGGRKKKKAPSASDSDSKAD--------------SDGAKPEPVAMARSA 254
Query: 139 HAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSR------------- 185
+ +S+ D+ D + K +G + P P PKP S
Sbjct: 255 SSSSSSSSSSDS-DVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRI 313
Query: 186 KQWRNRQKNKRR 197
+W+ R + +RR
Sbjct: 314 SEWKRRDEARRR 325
Score = 30.4 bits (67), Expect = 3.5
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 9/103 (8%)
Query: 56 PPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKK 115
PPS S+ E E E KK KK S+S E +K +K +K+ P + + + ++
Sbjct: 393 PPSSSDSEPEAELEREAKKSAKKPQ--SSSTEPARKPGQK-EKRVRPEEKQQAKPVKVER 449
Query: 116 CHKQALVGSDSAEDEKRK-----RKCQK-HAPINSAQHLDNVD 152
K++ S + EK+K K QK H+ I A +D+ D
Sbjct: 450 TRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPD 492
>gi|42476169 Paf1, RNA polymerase II associated factor, homolog
[Homo sapiens]
Length = 531
Score = 40.8 bits (94), Expect = 0.003
Identities = 42/147 (28%), Positives = 64/147 (43%), Gaps = 14/147 (9%)
Query: 44 LRALEA--ASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGP 101
L A EA A L H P EEEEEE + K+A + E G +K+ +
Sbjct: 361 LEAQEARKAQLENHEP-------EEEEEEEMETEEKEAGGSDEEQEKGSSSEKEGSEDEH 413
Query: 102 PCSDSE-EEVERKKKCHKQALVGSDSAEDEKRKRKCQKH---APINSAQHLDNVDQTGPK 157
S+SE EE +R + K +S+EDE R + ++ + +S D+ D+ +
Sbjct: 414 SGSESEREEGDRDEASDKSGSGEDESSEDEARAARDKEEIFGSDADSEDDADSDDEDRGQ 473
Query: 158 AWKGSTTNDPPKQSPGSTSPKPPHTLS 184
A +G + ND S G H+ S
Sbjct: 474 A-QGGSDNDSDSGSNGGGQRSRSHSRS 499
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 40.8 bits (94), Expect = 0.003
Identities = 39/142 (27%), Positives = 62/142 (43%), Gaps = 20/142 (14%)
Query: 12 PVAAGLGPVISRPPPAASSQNKGSK-------RRQLLATLRALEAASLSQHPPSLC-ISD 63
P G P RPP ++SS + + +R+ A R LEA + L + +
Sbjct: 285 PKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLRE 344
Query: 64 SEEEEEERKKKCPKKASFASASA-----------EVGKKGKKKCQKQGPPCS-DSEEEVE 111
E+EE+ER+++ + S E KK +K + +GPP S DSE E E
Sbjct: 345 QEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAE 404
Query: 112 RKKKCHKQALVGSDSAEDEKRK 133
+++ K A S+ + RK
Sbjct: 405 LEREAKKSAKKPQSSSTEPARK 426
Score = 31.2 bits (69), Expect = 2.0
Identities = 44/192 (22%), Positives = 70/192 (36%), Gaps = 38/192 (19%)
Query: 29 SSQNKGSKRR----QLLATLRA------LEAASLSQHPPSLCISDSEEEEEERKKKCPKK 78
SS N G KR+ ++ + RA L+ AS+S S SE E+ + P+K
Sbjct: 149 SSDNSGLKRKTPALKMSVSKRARKASSDLDQASVSPSEEENSESSSESEKTSDQDFTPEK 208
Query: 79 ASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQK 138
+ A G+KK + SDS+ + SD A+ E
Sbjct: 209 KAAVRAPRRGPLGGRKKKKAPSASDSDSKAD--------------SDGAKPEPVAMARSA 254
Query: 139 HAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTLSR------------- 185
+ +S+ D+ D + K +G + P P PKP S
Sbjct: 255 SSSSSSSSSSDS-DVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRI 313
Query: 186 KQWRNRQKNKRR 197
+W+ R + +RR
Sbjct: 314 SEWKRRDEARRR 325
Score = 30.4 bits (67), Expect = 3.5
Identities = 31/103 (30%), Positives = 49/103 (47%), Gaps = 9/103 (8%)
Query: 56 PPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKK 115
PPS S+ E E E KK KK S+S E +K +K +K+ P + + + ++
Sbjct: 393 PPSSSDSEPEAELEREAKKSAKKPQ--SSSTEPARKPGQK-EKRVRPEEKQQAKPVKVER 449
Query: 116 CHKQALVGSDSAEDEKRK-----RKCQK-HAPINSAQHLDNVD 152
K++ S + EK+K K QK H+ I A +D+ D
Sbjct: 450 TRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPD 492
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/131 (26%), Positives = 55/131 (41%), Gaps = 9/131 (6%)
Query: 5 PEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDS 64
P + + AG G S P S+ +KG +R +A + SL +
Sbjct: 1283 PRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-----KASGDVKEKKGKGSLGSQGA 1337
Query: 65 EEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGS 124
++E EE +K S KK KKK K+ +E+ E+KKK K + S
Sbjct: 1338 KDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR----KKDKEKKEKKKKAKKASTKDS 1393
Query: 125 DSAEDEKRKRK 135
+S +K+K+K
Sbjct: 1394 ESPSQKKKKKK 1404
>gi|207113162 Treacher Collins-Franceschetti syndrome 1 isoform e
[Homo sapiens]
Length = 1451
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/131 (26%), Positives = 55/131 (41%), Gaps = 9/131 (6%)
Query: 5 PEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDS 64
P + + AG G S P S+ +KG +R +A + SL +
Sbjct: 1322 PRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-----KASGDVKEKKGKGSLGSQGA 1376
Query: 65 EEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGS 124
++E EE +K S KK KKK K+ +E+ E+KKK K + S
Sbjct: 1377 KDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR----KKDKEKKEKKKKAKKASTKDS 1432
Query: 125 DSAEDEKRKRK 135
+S +K+K+K
Sbjct: 1433 ESPSQKKKKKK 1443
>gi|207113160 Treacher Collins-Franceschetti syndrome 1 isoform d
[Homo sapiens]
Length = 1488
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/131 (26%), Positives = 55/131 (41%), Gaps = 9/131 (6%)
Query: 5 PEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDS 64
P + + AG G S P S+ +KG +R +A + SL +
Sbjct: 1359 PRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-----KASGDVKEKKGKGSLGSQGA 1413
Query: 65 EEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGS 124
++E EE +K S KK KKK K+ +E+ E+KKK K + S
Sbjct: 1414 KDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR----KKDKEKKEKKKKAKKASTKDS 1469
Query: 125 DSAEDEKRKRK 135
+S +K+K+K
Sbjct: 1470 ESPSQKKKKKK 1480
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b [Homo
sapiens]
Length = 1411
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/131 (26%), Positives = 55/131 (41%), Gaps = 9/131 (6%)
Query: 5 PEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDS 64
P + + AG G S P S+ +KG +R +A + SL +
Sbjct: 1282 PRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-----KASGDVKEKKGKGSLGSQGA 1336
Query: 65 EEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGS 124
++E EE +K S KK KKK K+ +E+ E+KKK K + S
Sbjct: 1337 KDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR----KKDKEKKEKKKKAKKASTKDS 1392
Query: 125 DSAEDEKRKRK 135
+S +K+K+K
Sbjct: 1393 ESPSQKKKKKK 1403
>gi|57164977 Treacher Collins-Franceschetti syndrome 1 isoform a [Homo
sapiens]
Length = 1450
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/131 (26%), Positives = 55/131 (41%), Gaps = 9/131 (6%)
Query: 5 PEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDS 64
P + + AG G S P S+ +KG +R +A + SL +
Sbjct: 1321 PRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRD-----KASGDVKEKKGKGSLGSQGA 1375
Query: 65 EEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGS 124
++E EE +K S KK KKK K+ +E+ E+KKK K + S
Sbjct: 1376 KDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKR----KKDKEKKEKKKKAKKASTKDS 1431
Query: 125 DSAEDEKRKRK 135
+S +K+K+K
Sbjct: 1432 ESPSQKKKKKK 1442
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 40.4 bits (93), Expect = 0.003
Identities = 56/243 (23%), Positives = 92/243 (37%), Gaps = 27/243 (11%)
Query: 16 GLGPVISRPPPAASSQNKGSKRRQ------LLATLR--ALEAASLSQHPPSLCISDSEEE 67
G G + P + + K K++Q +L L +LEA + ++ + +E
Sbjct: 28 GAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENN 87
Query: 68 EEE-----RKKKCPK--KASFASASAEVGKKGKKKCQKQGPPC------SDSEEEVER-- 112
EEE +KKK K K SF +E + K +K P SD +++ +
Sbjct: 88 EEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLP 147
Query: 113 ---KKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPK 169
K K K S EDE +K ++ + INS+ + ++ KG N K
Sbjct: 148 KKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNK 207
Query: 170 QSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTD 229
P S S K QK K K + + + ++A EK E+ +
Sbjct: 208 PGPNIESGNEDDDASFKIKTVAQK-KAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQ 266
Query: 230 SHE 232
S +
Sbjct: 267 SKQ 269
Score = 35.8 bits (81), Expect = 0.083
Identities = 36/141 (25%), Positives = 61/141 (43%), Gaps = 27/141 (19%)
Query: 2 FEEPEWAEAAPVAAGLGPVI---SRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPS 58
FEE V G+ P + P AA N+G K+++ +
Sbjct: 276 FEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG------------ 323
Query: 59 LCISDSEEEEEERKKKCPKKASFASASAEVGK-KGKKKCQKQGPPCSDSEEEVERKKKCH 117
+EE+E+ KKK P KA+ + + K K +++ QK+ + EE ++R ++
Sbjct: 324 -----EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKR-----EEEERIKRLEELE 373
Query: 118 KQALVGSDSAEDEKRKRKCQK 138
+ + E EKR+RK QK
Sbjct: 374 AKR-KEEERLEQEKRERKKQK 393
>gi|23111062 splicing factor, arginine/serine-rich 8 [Homo sapiens]
Length = 951
Score = 40.0 bits (92), Expect = 0.004
Identities = 51/201 (25%), Positives = 83/201 (41%), Gaps = 33/201 (16%)
Query: 50 ASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEE 109
+S S+ PP EEE+E+KKK KK S + + + P S +
Sbjct: 742 SSKSKDPP-------REEEKEKKKKKHKKRS--------------RTRSRSPKYHSSSKS 780
Query: 110 VERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLD--NVDQTGPKAWKGSTTNDP 167
+ + H +A SA R+ + + +P A + +++ P A++ S +
Sbjct: 781 ---RSRSHSKAKHSLPSAYRTVRRSRSRSRSPRRRAHSPERRREERSVPTAYRVSRS--- 834
Query: 168 PKQSPGSTSPKPPHTLSRK-QWRNRQKNKRRCKNKFQPPQVPDQ--APAEAPTEKTEVSP 224
P S T + PH +K + R+R K+K R ++ Q + APA VSP
Sbjct: 835 PGASRKRTRSRSPHEKKKKRRSRSRTKSKARSQSVSPSKQAAPRPAAPAAHSAHSASVSP 894
Query: 225 V-PRTDSHEARAGALRARMAQ 244
V R S E G + + AQ
Sbjct: 895 VESRGSSQERSRGVSQEKEAQ 915
Score = 30.4 bits (67), Expect = 3.5
Identities = 33/164 (20%), Positives = 63/164 (38%), Gaps = 24/164 (14%)
Query: 61 ISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQA 120
+ D +++EE K+ +S A+ + V +K+ P + E E ++ K+ +
Sbjct: 600 LDDDSDDDEESKEGQESSSSAANTNPAVAPPCVVVEEKK-PQLTQEELEAKQAKQKLEDR 658
Query: 121 LVGSD-----SAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGST 175
L + A E ++++ Q +A L + P+A G P ST
Sbjct: 659 LAAAAREKLAQASKESKEKQLQAERKRKAALFLQTLKNPLPEAEAGKIEESPFSVEESST 718
Query: 176 SPKP------------------PHTLSRKQWRNRQKNKRRCKNK 201
+P P P + S+ R +K K++ K+K
Sbjct: 719 TPCPLLTGGRPLPTLEVKPPDRPSSKSKDPPREEEKEKKKKKHK 762
>gi|178557734 microtubule-associated protein tau isoform 6 [Homo
sapiens]
Length = 776
Score = 39.7 bits (91), Expect = 0.006
Identities = 60/276 (21%), Positives = 106/276 (38%), Gaps = 32/276 (11%)
Query: 5 PEWAEAAPVAAGLGPVISRPPP------AASSQNKGSKRRQLLATLRALEAASLSQHPPS 58
PE +E P AA G +SR P + S GS ++ + R+ A +L P
Sbjct: 352 PEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRS-SAKTLKNRP-- 408
Query: 59 LCISDSEEE--------EEERKKKCPKKAS----FASASAEVGKKGKKKCQKQGPPCSDS 106
C+S + CP+ S +S ++ G G K+ + +G +D
Sbjct: 409 -CLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKHVSSVTSRTGSSGAKEMKLKG---ADG 464
Query: 107 EEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTND 166
+ ++ + G +A K P +SA V + P A S +
Sbjct: 465 KTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSA--TKQVQRRPPPAGPRSERGE 522
Query: 167 PPKQS--PGSTSPKPPHTL-SRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVS 223
PPK G +SP P T SR + + R K + P ++P+ A + + + +
Sbjct: 523 PPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKS-RLQTA 581
Query: 224 PVPRTDSHEARAG-ALRARMAQRLDGARFRYLNEQL 258
PVP D ++ + + G + + +N++L
Sbjct: 582 PVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKL 617
>gi|38492356 DNA-directed DNA polymerase delta 3 [Homo sapiens]
Length = 466
Score = 39.7 bits (91), Expect = 0.006
Identities = 34/130 (26%), Positives = 57/130 (43%), Gaps = 26/130 (20%)
Query: 77 KKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVGSDSAEDEKRKRKC 136
KK+S + +V +K KK+ ++ +++E +KK + L SDS+EDE
Sbjct: 282 KKSSKKAEPVKVLQKEKKRGKRVALSDDETKETENMRKKRRRIKLPESDSSEDE------ 335
Query: 137 QKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSP-----GSTSPKPPHTLSRKQWRNR 191
V P A++ + + PP SP T P+PP ++ N+
Sbjct: 336 --------------VFPDSPGAYEAESPSPPPPPSPPLEPVPKTEPEPP-SVKSSSGENK 380
Query: 192 QKNKRRCKNK 201
+K KR K+K
Sbjct: 381 RKRKRVLKSK 390
>gi|38488727 arginine/serine-rich coiled-coil 1 [Homo sapiens]
Length = 334
Score = 39.7 bits (91), Expect = 0.006
Identities = 33/148 (22%), Positives = 68/148 (45%), Gaps = 15/148 (10%)
Query: 62 SDSEEEEEERKKKCPKKASFASASAEV--------GKKGKKKCQKQGPPCSDSEEEVERK 113
SD+EEE ++KK ++ S +S+S++ G+K + K + +R+
Sbjct: 6 SDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSYDRR 65
Query: 114 KKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPG 173
++ H+ + S S+ +RKR + + V ++ K+ + + P +S
Sbjct: 66 RR-HRSS---SSSSYGSRRKRSRSRSRGRGKSY---RVQRSRSKSRTRRSRSRPRLRSHS 118
Query: 174 STSPKPPHTLSRKQWRNRQKNKRRCKNK 201
+S + H +R + R+R++ K R K K
Sbjct: 119 RSSERSSHRRTRSRSRDRERRKGRDKEK 146
>gi|50659095 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 [Homo
sapiens]
Length = 783
Score = 39.7 bits (91), Expect = 0.006
Identities = 46/175 (26%), Positives = 71/175 (40%), Gaps = 15/175 (8%)
Query: 64 SEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALVG 123
+EE+E++ K K K A V K K+ +K P D +K K K+
Sbjct: 27 TEEKEKKEKPKSDKTEEIAEEEETVFPKAKQVKKKAEPSEVDMNSPKSKKAK-KKEEPSQ 85
Query: 124 SDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHTL 183
+D + K RK K PI + K T N+ P + +PKP
Sbjct: 86 NDISPKTKSLRK--KKEPIEK--------KVVSSKTKKVTKNEEPSEEE-IDAPKPKKMK 134
Query: 184 SRKQWRNRQKNKR-RCKNKFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGA 237
K+ + K + KN F P+ PD P+EA +E++ S + + E + GA
Sbjct: 135 KEKEMNGETREKSPKLKNGFPHPE-PDCNPSEAASEESN-SEIEQEIPVEQKEGA 187
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 39.3 bits (90), Expect = 0.007
Identities = 41/179 (22%), Positives = 73/179 (40%), Gaps = 21/179 (11%)
Query: 61 ISDSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDS---------EEEVE 111
+ + E+ +E + K+ PKKA A A + KK +K+ P ++ E VE
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 112 RKKKCHKQALVGSDSAEDEKRKRKCQKHAPIN-------SAQHLDNVDQTGPKAWKGSTT 164
+ K+ +A + AED+K+ +K AP + V + P K
Sbjct: 884 KPKESKVEA--KKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEP 941
Query: 165 NDPPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVS 223
+ P ++ +P+ T K + +K K K K + + + P++ EK E S
Sbjct: 942 SKPAEKK--EAAPEKKDTKEEKAKKPEEKPKTEAKAK-EDDKTLSKEPSKPKAEKAEKS 997
Score = 33.5 bits (75), Expect = 0.41
Identities = 31/118 (26%), Positives = 50/118 (42%), Gaps = 8/118 (6%)
Query: 63 DSEEEEEERKKKCPKKASFASASAEVGK--KGKKKCQKQGPPCSDSEEEVERKKKCHKQA 120
++++EE E KKK P A A EV + K K+K + D++ + K K+A
Sbjct: 891 EAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEA 950
Query: 121 LVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGP------KAWKGSTTNDPPKQSP 172
++EK K+ +K A+ D P KA K S+T+ + P
Sbjct: 951 APEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP 1008
Score = 30.8 bits (68), Expect = 2.7
Identities = 37/189 (19%), Positives = 71/189 (37%), Gaps = 19/189 (10%)
Query: 57 PSLCISDSEEEEEERKKKCPKKASFASASAE--------VGKKGKKKCQKQGPPCSDSEE 108
P S +E+ + +K+ PKK S E V + KK +++ P +EE
Sbjct: 796 PEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEE 855
Query: 109 EVERKKKCHKQALVGSDSAEDEKRKRKC-QKHAPINSAQHLDNVDQTGPKAWKGSTTNDP 167
+ + KK+ ++ + E K K +K P V+ +A P
Sbjct: 856 KKDSKKE---------EAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTP 906
Query: 168 PKQSPGSTSPKPPHTLSRK-QWRNRQKNKRRCKNKFQPPQVPDQAPAEAPTEKTEVSPVP 226
K++P K K + ++ + + K +P + + AP + T++ +
Sbjct: 907 EKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE 966
Query: 227 RTDSHEARA 235
EA+A
Sbjct: 967 EKPKTEAKA 975
Score = 30.4 bits (67), Expect = 3.5
Identities = 47/236 (19%), Positives = 91/236 (38%), Gaps = 15/236 (6%)
Query: 5 PEWAEAAPVAAGLGPVISRPPPAASSQNKGSKRRQLLATLRALEAASLSQHPPSLCISDS 64
P A+P PV A +++ + + A +++ E A + ++
Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEA 564
Query: 65 EEEEEERKK-----KCPKKA-SFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHK 118
+ E+E K K P+KA S A A+ + K + + P +++ E K +
Sbjct: 565 KSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKE 624
Query: 119 QALVGSDSAEDEKRKRKCQKHAPI-NSAQHLDNVDQTGPKAWKG---STTNDPPK-QSPG 173
+A ++ EK K ++ A A+ + + P+ K + P K +SP
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684
Query: 174 STSPKPPHTLS---RKQWRNRQKNKRRCKNKFQPPQ-VPDQAPAEAPTEKTEVSPV 225
K P +++ ++ +K K K + + P+ EA T + SPV
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPV 740
>gi|5174573 myeloid/lymphoid or mixed-lineage leukemia trithorax
homolog 2 [Homo sapiens]
Length = 1210
Score = 38.9 bits (89), Expect = 0.010
Identities = 50/201 (24%), Positives = 77/201 (38%), Gaps = 19/201 (9%)
Query: 54 QHPPSLCISDS--EEEEEERKKKCPKKASFA-SASAEVGKKGKKKCQK----QGPPCSDS 106
+HP S SDS +E E K PK +S A A E GK+ CQK Q PP +
Sbjct: 540 RHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQT 599
Query: 107 EEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTND 166
+ KK A GS ++ +R+ + + DQT K T
Sbjct: 600 VGTKQPKKPVKASARAGSRTSLQGEREPGLLPYG---------SRDQTSKDKPKVKTKGR 650
Query: 167 PPKQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQ--VPDQAPAE-APTEKTEVS 223
P + P P + +K+ ++ + + +P + V D+ P A TE
Sbjct: 651 PRAAASNEPKPAVPPSSEKKKHKSSLPAPSKALSGPEPAKDNVEDRTPEHFALVPLTESQ 710
Query: 224 PVPRTDSHEARAGALRARMAQ 244
P + S +G +A + Q
Sbjct: 711 GPPHSGSGSRTSGCRQAVVVQ 731
Score = 35.4 bits (80), Expect = 0.11
Identities = 47/210 (22%), Positives = 78/210 (37%), Gaps = 28/210 (13%)
Query: 59 LCISDSEEEEEERKKKCPKKASFASASAE-----VGKKGKKKCQKQGPPCSDSEEEVERK 113
L +SDSE+ + E+ + P +S ++ + V + + SDS + E +
Sbjct: 427 LQLSDSEDSDSEQTPEKPPSSSAPPSAPQSLPEPVASAHSSSAESESTSDSDSSSDSESE 486
Query: 114 KKCHKQALVGSDSAEDEKRKRKC-QKHAPINSAQHLDN----VDQTGPKAWKGSTTNDPP 168
SDS E+E + + P + LDN V Q +G + +PP
Sbjct: 487 SS-------SSDSEENEPLETPAPEPEPPTTNKWQLDNWLTKVSQPAAPP-EGPRSTEPP 538
Query: 169 KQSPGSTSPKPPHTLSRKQWRNRQKNKRRCKNKFQPPQVP-------DQAPA--EAPTEK 219
++ P S T K K PP+ P ++PA E P +
Sbjct: 539 RRHPESKGSSDSATSQEHSESKDPPPKSSSKAPRAPPEAPHPGKRSCQKSPAQQEPPQRQ 598
Query: 220 TEVSPVPRTD-SHEARAGALRARMAQRLDG 248
T + P+ ARAG+ + +R G
Sbjct: 599 TVGTKQPKKPVKASARAGSRTSLQGEREPG 628
Score = 33.1 bits (74), Expect = 0.54
Identities = 34/171 (19%), Positives = 63/171 (36%), Gaps = 21/171 (12%)
Query: 35 SKRRQLLATLRALEAASLSQHPPSLCISDSEEEEEERKKKCPKKASFASASAEVGKKGKK 94
+K+ +L +++ ++S S H S S + KK+ +S+S + K K
Sbjct: 824 NKKIRLEKEIKSQSSSSSSSHKESSKTKPSRPSSQSSKKEMLPPPPVSSSSQKPAKPALK 883
Query: 95 KCQKQGPPC-SDSEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQ 153
+ +++ C D + K HK + + + K R +H
Sbjct: 884 RSRREADTCGQDPPKSASSTKSNHKDSSIPKQRRVEGKGSRSSSEH-------------- 929
Query: 154 TGPKAWKGSTTNDPPKQS--PGSTSP-KPPHTLSRKQWRNRQKNKRRCKNK 201
K G T N P S G++ P KP ++Q + ++ K K
Sbjct: 930 ---KGSSGDTANPFPVPSLPNGNSKPGKPQVKFDKQQADLHMREAKKMKQK 977
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 38.9 bits (89), Expect = 0.010
Identities = 58/230 (25%), Positives = 89/230 (38%), Gaps = 34/230 (14%)
Query: 62 SDSEEEEEERKKKCPKKASFASASAEV------GKKGKKKCQK-QGPPCS---------D 105
SD+++ E+R K+CP ++ +V G G K K +G P S +
Sbjct: 562 SDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFRE 621
Query: 106 SEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTN 165
++ ER K ++ L + S E + P A+ LD + TG + S TN
Sbjct: 622 DTDDTERNK-AQREPLTRARSEE----MGRIVPGLPSGWAKFLDPI--TGTFRYYHSPTN 674
Query: 166 D----PPKQSPGSTSPKPPHTLSRKQW--RNRQKNKRRCKNKFQPPQVPDQAPAEAPTEK 219
PP+ +P S P P T K R + + K + P + QA E K
Sbjct: 675 TVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDI-TQAIQEEEKRK 733
Query: 220 TEVSPVPRTDSHEARAGALRARMAQRLDGARFRYLNEQL-YSGPSSAAQR 268
V+P T + E + RL ++ R LN SGP+ R
Sbjct: 734 PTVTP---TVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 38.9 bits (89), Expect = 0.010
Identities = 58/230 (25%), Positives = 89/230 (38%), Gaps = 34/230 (14%)
Query: 62 SDSEEEEEERKKKCPKKASFASASAEV------GKKGKKKCQK-QGPPCS---------D 105
SD+++ E+R K+CP ++ +V G G K K +G P S +
Sbjct: 562 SDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFRE 621
Query: 106 SEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTN 165
++ ER K ++ L + S E + P A+ LD + TG + S TN
Sbjct: 622 DTDDTERNK-AQREPLTRARSEE----MGRIVPGLPSGWAKFLDPI--TGTFRYYHSPTN 674
Query: 166 D----PPKQSPGSTSPKPPHTLSRKQW--RNRQKNKRRCKNKFQPPQVPDQAPAEAPTEK 219
PP+ +P S P P T K R + + K + P + QA E K
Sbjct: 675 TVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDI-TQAIQEEEKRK 733
Query: 220 TEVSPVPRTDSHEARAGALRARMAQRLDGARFRYLNEQL-YSGPSSAAQR 268
V+P T + E + RL ++ R LN SGP+ R
Sbjct: 734 PTVTP---TVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 38.9 bits (89), Expect = 0.010
Identities = 58/230 (25%), Positives = 89/230 (38%), Gaps = 34/230 (14%)
Query: 62 SDSEEEEEERKKKCPKKASFASASAEV------GKKGKKKCQK-QGPPCS---------D 105
SD+++ E+R K+CP ++ +V G G K K +G P S +
Sbjct: 562 SDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSGKPFKIKGQPESGILRTGTFRE 621
Query: 106 SEEEVERKKKCHKQALVGSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTN 165
++ ER K ++ L + S E + P A+ LD + TG + S TN
Sbjct: 622 DTDDTERNK-AQREPLTRARSEE----MGRIVPGLPSGWAKFLDPI--TGTFRYYHSPTN 674
Query: 166 D----PPKQSPGSTSPKPPHTLSRKQW--RNRQKNKRRCKNKFQPPQVPDQAPAEAPTEK 219
PP+ +P S P P T K R + + K + P + QA E K
Sbjct: 675 TVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSPDI-TQAIQEEEKRK 733
Query: 220 TEVSPVPRTDSHEARAGALRARMAQRLDGARFRYLNEQL-YSGPSSAAQR 268
V+P T + E + RL ++ R LN SGP+ R
Sbjct: 734 PTVTP---TVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR 780
>gi|156564398 target of EGR1, member 1 (nuclear) [Homo sapiens]
Length = 510
Score = 38.9 bits (89), Expect = 0.010
Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 15/118 (12%)
Query: 125 DSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPPHT-- 182
++A ++KR+R+ ++ + +L +G + PPK+ S KP T
Sbjct: 329 EAAAEDKRRRRRRREKRKRALLNLPGTQTSG------EAKDGPPKKQVCGDSIKPEETEQ 382
Query: 183 -LSRKQWRNRQKNKRRCKN------KFQPPQVPDQAPAEAPTEKTEVSPVPRTDSHEA 233
++ + RN +K+ KN K P++ D+A +E P + +PVP H A
Sbjct: 383 EVAADETRNLPHSKQGNKNDLEMGIKAARPEIADRATSEVPGSQASPNPVPGDGLHRA 440
>gi|22748973 protein interacting with cyclin A1 [Homo sapiens]
Length = 336
Score = 38.5 bits (88), Expect = 0.013
Identities = 45/186 (24%), Positives = 74/186 (39%), Gaps = 18/186 (9%)
Query: 63 DSEEEEEERKKKCPKKASFASASAEVGKKGKKKCQKQGPPCSDSEEEVERKKKCHKQALV 122
+ EEEEEE K P + A+AS ++G G P S + + R + +
Sbjct: 147 EEEEEEEESKPPIPTQVGPATASPDLGTS-----MATGTPDSTAPITIWRSESPTGK--- 198
Query: 123 GSDSAEDEKRKRKCQKHAPINSAQHLDNVDQTGPKAWKGSTTNDPPKQSPGSTSPKPP-- 180
G S +K K+K +K + +D + KA KG T K+SP P PP
Sbjct: 199 GQGSKVIKKVKKKKEKE---KDKEEMDEKAKLKKKAKKGQLTK---KKSPVKLEPSPPDV 252
Query: 181 -HTLSRKQWRNRQKNKRRCKNKFQ-PPQVPDQAPAEAPTEKTEVSPVPRTDSHEARAGAL 238
+LS +Q ++ + + + + E +E S PR + +A
Sbjct: 253 SRSLSARQLARMSESSPESREELESEDSYNGRGQGELSSEDIVESSSPRKRENTVQAKKT 312
Query: 239 RARMAQ 244
A+ +Q
Sbjct: 313 GAKPSQ 318
>gi|153251913 hypothetical protein LOC57604 isoform 1 [Homo sapiens]
Length = 454
Score = 38.5 bits (88), Expect = 0.013
Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 20/118 (16%)
Query: 287 QVKKWPLQPVDRIARDLRQRPASLVVADFGCGDCRLASSIRNPVHCFDLASLDPRV---- 342
Q K WP R+ + L+++ ++AD GCG + + + VH P V
Sbjct: 28 QSKAWP-----RVRQFLQEQKPGSLIADIGCGTGKYL-KVNSQVHTVGCDYCGPLVEIAR 81
Query: 343 ------TVCDMAQVPLEDESVD--VAVFCLSLMGTNIRDF--LEEANRVLKPGGLLKV 390
VCD +P DE D +++ + T R ++E RVL PGG L +
Sbjct: 82 NRGCEAMVCDNLNLPFRDEGFDAIISIGVIHHFSTKQRRIRAIKEMARVLVPGGQLMI 139
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.388
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,807,831
Number of Sequences: 37866
Number of extensions: 1063155
Number of successful extensions: 8287
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 52
Number of HSP's successfully gapped in prelim test: 339
Number of HSP's that attempted gapping in prelim test: 7125
Number of HSP's gapped (non-prelim): 1158
length of query: 456
length of database: 18,247,518
effective HSP length: 106
effective length of query: 350
effective length of database: 14,233,722
effective search space: 4981802700
effective search space used: 4981802700
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.