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Search of human proteins with 12711676
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|12711676 UPF3 regulator of nonsense transcripts homolog A
isoform hUpf3p [Homo sapiens]
(476 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|12711676 UPF3 regulator of nonsense transcripts homolog A iso... 959 0.0
gi|18375525 UPF3 regulator of nonsense transcripts homolog A iso... 879 0.0
gi|12711674 UPF3 regulator of nonsense transcripts homolog B iso... 398 e-111
gi|18375528 UPF3 regulator of nonsense transcripts homolog B iso... 389 e-108
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 77 3e-14
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 77 3e-14
gi|148746195 trichohyalin [Homo sapiens] 75 1e-13
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 73 5e-13
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 73 6e-13
gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo sapi... 72 8e-13
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 70 3e-12
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 68 2e-11
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 67 5e-11
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 66 6e-11
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 66 8e-11
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 65 1e-10
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 65 1e-10
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 64 3e-10
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 64 3e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 63 5e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 63 7e-10
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 62 9e-10
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 62 9e-10
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 61 2e-09
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 3e-09
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 60 3e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 60 4e-09
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 60 4e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 60 4e-09
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 60 4e-09
>gi|12711676 UPF3 regulator of nonsense transcripts homolog A
isoform hUpf3p [Homo sapiens]
Length = 476
Score = 959 bits (2480), Expect = 0.0
Identities = 476/476 (100%), Positives = 476/476 (100%)
Query: 1 MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR 60
MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR
Sbjct: 1 MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR 60
Query: 61 EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN 120
EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN
Sbjct: 61 EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN 120
Query: 121 PDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKF 180
PDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKF
Sbjct: 121 PDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKF 180
Query: 181 LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR 240
LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR
Sbjct: 181 LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR 240
Query: 241 RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 300
RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE
Sbjct: 241 RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 300
Query: 301 RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR 360
RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR
Sbjct: 301 RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR 360
Query: 361 YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC 420
YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC
Sbjct: 361 YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC 420
Query: 421 DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE 476
DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE
Sbjct: 421 DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE 476
>gi|18375525 UPF3 regulator of nonsense transcripts homolog A
isoform hUpf3pdelta [Homo sapiens]
Length = 443
Score = 879 bits (2270), Expect = 0.0
Identities = 443/476 (93%), Positives = 443/476 (93%), Gaps = 33/476 (6%)
Query: 1 MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR 60
MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR
Sbjct: 1 MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR 60
Query: 61 EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN 120
EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN
Sbjct: 61 EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN 120
Query: 121 PDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKF 180
PDDILLFRDRFDGYIFLDSK DPEYKKF
Sbjct: 121 PDDILLFRDRFDGYIFLDSK---------------------------------DPEYKKF 147
Query: 181 LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR 240
LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR
Sbjct: 148 LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR 207
Query: 241 RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 300
RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE
Sbjct: 208 RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 267
Query: 301 RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR 360
RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR
Sbjct: 268 RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR 327
Query: 361 YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC 420
YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC
Sbjct: 328 YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC 387
Query: 421 DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE 476
DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE
Sbjct: 388 DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE 443
>gi|12711674 UPF3 regulator of nonsense transcripts homolog B
isoform 2 [Homo sapiens]
Length = 470
Score = 398 bits (1023), Expect = e-111
Identities = 214/451 (47%), Positives = 302/451 (66%), Gaps = 40/451 (8%)
Query: 30 EVQFHRDSQQQEAETPPTSSSGCGGGA------GKPRE----EKRTALSKVVIRRLPPGL 79
E + HR +++ P ++G GGG G+ ++ EK+ ALSKVVIRRLPP L
Sbjct: 3 EEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPPTL 62
Query: 80 TKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDS 139
TKEQL+E L+P+P HDYFEFF+ D SLYPH+Y+RAYINF+N +DI+LFRDRFDGY+FLD+
Sbjct: 63 TKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFLDN 122
Query: 140 KGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLL 199
KG EYPA+VEFAPFQK AKKK +K+D K G+I+DDPEY+KFLE+Y + EK ++ PETLL
Sbjct: 123 KGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLL 182
Query: 200 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRRE 259
E+EAK RELIA++TTPLL ++KN KQR+REEKREERRRRE+E+KR REEE+R+ +E
Sbjct: 183 EEIEAKNRELIAKKTTPLLSFLKN----KQRMREEKREERRRREIERKRQREEERRKWKE 238
Query: 260 EERCKKKETDKQKKI--------AEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK 311
EE+ K+K+ +K KKI + E +IKLLKKPEKG+E +K +E+ +++D
Sbjct: 239 EEKRKRKDIEKLKKIDRIPERDKLKDEPKIKLLKKPEKGDEKELDK-REKAKKLDKENLS 297
Query: 312 QESCAPGAVVKARPMEGSLEE-----PQETSHSGSDKEHRDVERSQE---QESEAQRYHV 363
E + + + + L++ P++ S + R+ ER QE +E E +
Sbjct: 298 DERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQE 357
Query: 364 DDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCD-D 422
++ RR + +E E+ +R E+E + K +D+GKK E+ E +G +++ +
Sbjct: 358 EERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK--------AESTESIGSSEKTEKK 409
Query: 423 SPAPRKERLANKDRPALQLYDPGARFRAREC 453
+++R+ NKDRPA+QLY PGAR R R C
Sbjct: 410 EEVVKRDRIRNKDRPAMQLYQPGARSRNRLC 440
>gi|18375528 UPF3 regulator of nonsense transcripts homolog B
isoform 1 [Homo sapiens]
Length = 483
Score = 389 bits (999), Expect = e-108
Identities = 214/464 (46%), Positives = 302/464 (65%), Gaps = 53/464 (11%)
Query: 30 EVQFHRDSQQQEAETPPTSSSGCGGGA------GKPRE----EKRTALSKVVIRRLPPGL 79
E + HR +++ P ++G GGG G+ ++ EK+ ALSKVVIRRLPP L
Sbjct: 3 EEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPPTL 62
Query: 80 TKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDS 139
TKEQL+E L+P+P HDYFEFF+ D SLYPH+Y+RAYINF+N +DI+LFRDRFDGY+FLD+
Sbjct: 63 TKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFLDN 122
Query: 140 KGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLL 199
KG EYPA+VEFAPFQK AKKK +K+D K G+I+DDPEY+KFLE+Y + EK ++ PETLL
Sbjct: 123 KGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLL 182
Query: 200 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRRE 259
E+EAK RELIA++TTPLL ++KN KQR+REEKREERRRRE+E+KR REEE+R+ +E
Sbjct: 183 EEIEAKNRELIAKKTTPLLSFLKN----KQRMREEKREERRRREIERKRQREEERRKWKE 238
Query: 260 EERCKKKETDKQKKI--------AEKEVRIK-------------LLKKPEKGEEPTTEKP 298
EE+ K+K+ +K KKI + E +IK LLKKPEKG+E +K
Sbjct: 239 EEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK- 297
Query: 299 KERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE-----PQETSHSGSDKEHRDVERSQE 353
+E+ +++D E + + + + L++ P++ S + R+ ER QE
Sbjct: 298 REKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQE 357
Query: 354 ---QESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEA 410
+E E + ++ RR + +E E+ +R E+E + K +D+GKK E+
Sbjct: 358 RILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK--------AES 409
Query: 411 MERLGRAQRCD-DSPAPRKERLANKDRPALQLYDPGARFRAREC 453
E +G +++ + +++R+ NKDRPA+QLY PGAR R R C
Sbjct: 410 TESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLC 453
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 77.4 bits (189), Expect = 3e-14
Identities = 63/253 (24%), Positives = 111/253 (43%), Gaps = 15/253 (5%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 281
K+R R R +++ RR + KKR + E+R+ R + K D ++KI EKE
Sbjct: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391
Query: 282 KLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGS 341
+ ++ E+ E EK KERG+ D +++ + + E E +E H
Sbjct: 392 EKDREKEREREKEREKEKERGKNKDRDKEREKD-------REKDKEKDREREREKEHEKD 444
Query: 342 DKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGS 401
+ ++ E+ +E+E E R D +R + + R RS + R + ++R ++ S
Sbjct: 445 RDKEKEKEQDKEKEREKDRSKEIDEKRKK--DKKSRTPPRSYNASRRSRSSSRERRRRRS 502
Query: 402 QDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICK 461
+ S + + R + SP+PR KD+ + D + R RE + R K
Sbjct: 503 RSSSRSPRTSKTIKR--KSSRSPSPRSRN--KKDKKREKERDHISERRERERSTSMR--K 556
Query: 462 AEGSGTGPEKREE 474
+ G EK E+
Sbjct: 557 SSNDRDGKEKLEK 569
Score = 69.3 bits (168), Expect = 7e-12
Identities = 61/222 (27%), Positives = 101/222 (45%), Gaps = 14/222 (6%)
Query: 219 EYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 278
E IK ++ K++ RE++RE + RE EK+R + +++ + RE++R K KE D++++ EKE
Sbjct: 382 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE-REKE 440
Query: 279 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK-QESCAP----GAVVKARPMEGSLEEP 333
K+ EK ++ E+ K+R +EID K ++S P A ++R
Sbjct: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 500
Query: 334 QETSHSGSDKEHRDVER-SQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 392
+ S S S + + ++R S S R D R H ER R R K
Sbjct: 501 RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMR--KSS 558
Query: 393 GQDRGKKGSQDSGAPGEAMER-----LGRAQRCDDSPAPRKE 429
GK+ + + + E ++ DD APR E
Sbjct: 559 NDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600
Score = 30.8 bits (68), Expect = 2.8
Identities = 36/148 (24%), Positives = 61/148 (41%), Gaps = 17/148 (11%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKT--RELIARRTT 215
K+K R+KD S E D + KK ++K+ P + +++ RE RR+
Sbjct: 455 KEKEREKDR---SKEIDEKRKK--------DKKSRTPPRSYNASRRSRSSSRERRRRRSR 503
Query: 216 PLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEER---CKKKETDKQK 272
+ K K++ R ++ +K+ + RRE ER +K D+
Sbjct: 504 SSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDG 563
Query: 273 KIAEKEVRIKLLKKPEKGEEPTTEKPKE 300
K + E LK+ E +EP + KE
Sbjct: 564 K-EKLEKNSTSLKEKEHNKEPDSSVSKE 590
Score = 29.6 bits (65), Expect = 6.3
Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 14/101 (13%)
Query: 211 ARRTTPLLEYIKNRKLEKQRIREEKREERRR--------------RELEKKRLREEEKRR 256
+R +P K++K EK+R +R ER R +LEK +EK
Sbjct: 520 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579
Query: 257 RREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEK 297
+E + KE D + +E +I+ + EE + K
Sbjct: 580 NKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTK 620
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 77.4 bits (189), Expect = 3e-14
Identities = 63/253 (24%), Positives = 111/253 (43%), Gaps = 15/253 (5%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 281
K+R R R +++ RR + KKR + E+R+ R + K D ++KI EKE
Sbjct: 216 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 275
Query: 282 KLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGS 341
+ ++ E+ E EK KERG+ D +++ + + E E +E H
Sbjct: 276 EKDREKEREREKEREKEKERGKNKDRDKEREKD-------REKDKEKDREREREKEHEKD 328
Query: 342 DKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGS 401
+ ++ E+ +E+E E R D +R + + R RS + R + ++R ++ S
Sbjct: 329 RDKEKEKEQDKEKEREKDRSKEIDEKRKK--DKKSRTPPRSYNASRRSRSSSRERRRRRS 386
Query: 402 QDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICK 461
+ S + + R + SP+PR KD+ + D + R RE + R K
Sbjct: 387 RSSSRSPRTSKTIKR--KSSRSPSPRSRN--KKDKKREKERDHISERRERERSTSMR--K 440
Query: 462 AEGSGTGPEKREE 474
+ G EK E+
Sbjct: 441 SSNDRDGKEKLEK 453
Score = 69.3 bits (168), Expect = 7e-12
Identities = 61/222 (27%), Positives = 101/222 (45%), Gaps = 14/222 (6%)
Query: 219 EYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 278
E IK ++ K++ RE++RE + RE EK+R + +++ + RE++R K KE D++++ EKE
Sbjct: 266 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE-REKE 324
Query: 279 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK-QESCAP----GAVVKARPMEGSLEEP 333
K+ EK ++ E+ K+R +EID K ++S P A ++R
Sbjct: 325 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 384
Query: 334 QETSHSGSDKEHRDVER-SQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 392
+ S S S + + ++R S S R D R H ER R R K
Sbjct: 385 RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMR--KSS 442
Query: 393 GQDRGKKGSQDSGAPGEAMER-----LGRAQRCDDSPAPRKE 429
GK+ + + + E ++ DD APR E
Sbjct: 443 NDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 484
Score = 30.8 bits (68), Expect = 2.8
Identities = 36/148 (24%), Positives = 61/148 (41%), Gaps = 17/148 (11%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKT--RELIARRTT 215
K+K R+KD S E D + KK ++K+ P + +++ RE RR+
Sbjct: 339 KEKEREKDR---SKEIDEKRKK--------DKKSRTPPRSYNASRRSRSSSRERRRRRSR 387
Query: 216 PLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEER---CKKKETDKQK 272
+ K K++ R ++ +K+ + RRE ER +K D+
Sbjct: 388 SSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDG 447
Query: 273 KIAEKEVRIKLLKKPEKGEEPTTEKPKE 300
K + E LK+ E +EP + KE
Sbjct: 448 K-EKLEKNSTSLKEKEHNKEPDSSVSKE 474
Score = 29.6 bits (65), Expect = 6.3
Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 14/101 (13%)
Query: 211 ARRTTPLLEYIKNRKLEKQRIREEKREERRR--------------RELEKKRLREEEKRR 256
+R +P K++K EK+R +R ER R +LEK +EK
Sbjct: 404 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 463
Query: 257 RREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEK 297
+E + KE D + +E +I+ + EE + K
Sbjct: 464 NKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTK 504
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 75.5 bits (184), Expect = 1e-13
Identities = 64/260 (24%), Positives = 120/260 (46%), Gaps = 21/260 (8%)
Query: 149 EFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRE 208
EF +++ +++L + K + ++ + EEEK ET+L + E K +E
Sbjct: 203 EFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
Query: 209 LIARRTTPLLEYIKN-RKLEKQRIREEKREE-----RRRRELEKKRLREEEKRRRREEER 262
+R L E + RKLE+Q +R E++EE R RRE + +R +EEE+R ++EE R
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 263 CKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVK 322
+++ ++Q++ E+++R ++ E+ E+ + +E E ++E + +
Sbjct: 323 EQQERREQQEERREQQLR---REQEERREQQLRREQEEERREQQLRREQEEERREQQLRR 379
Query: 323 ARPM--------EGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHE 374
+ + E L Q+ + + + R Q+ E Q + RH HE
Sbjct: 380 EQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHE 439
Query: 375 PE----RLSRRSEDEQRWGK 390
E RL R E+ + W K
Sbjct: 440 QERREQRLKREQEERRDWLK 459
Score = 65.9 bits (159), Expect = 8e-11
Identities = 69/313 (22%), Positives = 142/313 (45%), Gaps = 33/313 (10%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
+++L++++ + E + ++ E C EEE+ E LL E K R R
Sbjct: 1083 EEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYRE 1142
Query: 218 LEYIKNRKLEKQRIREEKREERRRRELEKKR-------------LREEEKRRRREEERCK 264
E ++ E+Q +REE E+RRR+ELE++ LREE+++RR+E ER
Sbjct: 1143 EEEVQQE--EEQLLREEP-EKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQY 1199
Query: 265 KKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKAR 324
++E + Q++ ++ R + + K + ++ R ++ G + E + R
Sbjct: 1200 REEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE--------QFR 1251
Query: 325 PMEGS----LEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHH-EPERLS 379
+E S + Q+ H +++ RD E+ + + + R+ ++ + R E +R
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 380 RRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPAL 439
R+S++E++ + +++ ++ D + E Q ++ P R+ER L
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDR----KFREEEQLLQEREEQPLRRQERDRKFREEEL 1367
Query: 440 QLYDPGARFRARE 452
+ + G +F E
Sbjct: 1368 RHQEQGRKFLEEE 1380
Score = 64.7 bits (156), Expect = 2e-10
Identities = 66/261 (25%), Positives = 121/261 (46%), Gaps = 45/261 (17%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTT-- 215
+K+ +D K + E + LE + + ++ + + LLGE + + RE RR
Sbjct: 1230 EKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQR 1289
Query: 216 ----PLLEYIKNRKL------------EKQRIREEKREERRRRELEKKRLREEEKRRRRE 259
P E ++ + EKQ +REE+ E+RRR+E ++K EE+ + RE
Sbjct: 1290 DRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQERE 1349
Query: 260 EERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGA 319
E+ +++E D +K E+E L+ E+G + E+ + R +E + K+E
Sbjct: 1350 EQPLRRQERD--RKFREEE-----LRHQEQGRKFLEEEQRLRRQERERKFLKEEQ----- 1397
Query: 320 VVKARPMEGSL---------EEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGR--- 367
++ + E L EE Q+ S D++ R+ E Q + E +R +++ +
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFRE-EEQQVRRQERERKFLEEEQQLR 1456
Query: 368 --RHRAHHEPERLSRRSEDEQ 386
RHR E E+L + E++Q
Sbjct: 1457 QERHRKFREEEQLLQEREEQQ 1477
Score = 61.2 bits (147), Expect = 2e-09
Identities = 87/314 (27%), Positives = 142/314 (45%), Gaps = 67/314 (21%)
Query: 154 QKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARR 213
Q+ ++ LR++ K E + +Y+ EEE+ E LLGE E +TR RR
Sbjct: 1027 QQEEEQLLREEREKRRLQERERQYR--------EEEELQQEEEQLLGE-ERETR----RR 1073
Query: 214 TTPLLEYIKNRKL---EKQRIREE----KREERRRRELEKKRLREEE---------KRRR 257
+Y K +L E+Q +REE +R+ER R+ E++ L++EE KRRR
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRR 1133
Query: 258 REEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAP 317
+E ER ++E + Q++ E+++ L ++PEK E+ EE+ +QE
Sbjct: 1134 QELERQYREEEEVQQE--EEQL---LREEPEKRRRQELERQYREEEEL-----QQEE--- 1180
Query: 318 GAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRH-RAHHEPE 376
E L E QE ++++R+ E Q Q+ + QRY +D R + EPE
Sbjct: 1181 ---------EQLLREEQEKRRQERERQYREEEELQRQKRK-QRYRDEDQRSDLKWQWEPE 1230
Query: 377 R---------LSRRSEDEQRWGKGPGQDRGKKGSQD-SGAPGEAMERLGRAQR----CDD 422
+ + E+EQ Q R ++ QD GE ER +R D
Sbjct: 1231 KENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRD 1290
Query: 423 SPAPRKERLANKDR 436
P +E+L +++
Sbjct: 1291 RHFPEEEQLEREEQ 1304
Score = 60.8 bits (146), Expect = 3e-09
Identities = 69/283 (24%), Positives = 122/283 (43%), Gaps = 44/283 (15%)
Query: 188 EEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKK 247
E++ E + ++ + + R E + R+ EK R+ +E+RE+R +RE E++
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEER 574
Query: 248 R---LREEEKRRR---------REEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTT 295
R L+ EE+RR+ R E+R K++E ++ ++ +E R+K ++PE+
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK-REEPEEERRQQL 633
Query: 296 EKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQ- 354
K +E+ E +++ +K E LE+ + H +E E QEQ
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693
Query: 355 ---------------ESEA--------QRYHVDDGRRHRAHHEPERLSRRSEDEQRW--- 388
ESEA R +G+R R E +R RR E E +W
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR--RRRESELQWQEE 751
Query: 389 GKGPGQDRGKKGSQDSGAPGEAMERLGRA-QRCDDSPAPRKER 430
+ Q + ++ +D +A E+ R QR P R++R
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR 794
Score = 60.5 bits (145), Expect = 3e-09
Identities = 51/204 (25%), Positives = 92/204 (45%), Gaps = 28/204 (13%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIAR---RTTPLLEYIKNRKLEKQRIREEKREERRRRE 243
E E+ A E L +T E R LLE + + EKQ+ R E R++R +E
Sbjct: 182 EREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE-RQDRVFQE 240
Query: 244 LEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGE 303
E+K R+ E R+EEE+ +++E +Q+++ E+E +++ L++ E E E+ +++
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 304 EIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHV 363
E L QE +E R+ + +EQ+ E + +
Sbjct: 301 R---------------------REQQLRRKQEEERREQQEERREQQERREQQEERREQQL 339
Query: 364 DDGRRHRAHHEPERLSRRSEDEQR 387
RR + ++L R E+E+R
Sbjct: 340 ---RREQEERREQQLRREQEEERR 360
Score = 58.2 bits (139), Expect = 2e-08
Identities = 73/332 (21%), Positives = 148/332 (44%), Gaps = 46/332 (13%)
Query: 159 KKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLL 218
+K R+++ E+ +++ + +EEE+ E + K RE R P
Sbjct: 1461 RKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQER-----DRKFREQELRSQEPER 1515
Query: 219 EYI----------KNRKL--EKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKK 266
+++ + RK E+Q++R ++R ++RR++ ++K EE+ R+ REE++ ++
Sbjct: 1516 KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575
Query: 267 ETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPM 326
E D++ ++ E++VR + ++ K E + ++ G Q+ K R
Sbjct: 1576 ERDRKFRLEEQKVRRQ--EQERKFMEDEQQLRRQEG---------QQQLRQERDRKFRED 1624
Query: 327 EGSLEEPQETSHSGSDKEHRDVERS---QEQESEAQRYHVDDGRRHRAHHEPERLSRRSE 383
E L+E +E +++ + +E + QE E Q H R R E E+L + E
Sbjct: 1625 EQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH----DRDRKFREEEQLLQEGE 1680
Query: 384 DEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQR-CDDSPAPRKERLANKDRPALQLY 442
++Q Q+R +K ++ + + R R ++ + R++ L K R QL
Sbjct: 1681 EQQL----RRQERDRKFREEE----QQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Query: 443 DPGARFRARECGGNRRICKAEGSGTGPEKREE 474
+ + R R+I + E PE+ E+
Sbjct: 1733 QETEQEQLRRQERYRKILEEE--QLRPEREEQ 1762
Score = 56.6 bits (135), Expect = 5e-08
Identities = 59/253 (23%), Positives = 112/253 (44%), Gaps = 27/253 (10%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 281
+ R L ++ +E++R +RR RE E + L EEE+ +RRE + ++E D ++ E+ R
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR-RS 865
Query: 282 KLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESC-APGAVVKARPMEGSLEEPQETSHSG 340
+ ++ +K E+ K R + QE +++ E EE ++
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925
Query: 341 SDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRR-----SEDEQRWGKGP--- 392
++++R+ E+ Q++E + R + R R E ER R+ ++EQ G+ P
Sbjct: 926 QERQYREEEQLQQEEEQLLR----EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 393 -GQDRGKKGSQDSGAPGEAMERL------------GRAQRCDDSPAPRKERLANKDRPAL 439
Q+R KK ++ E + L R R D +E+L ++R
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 440 QLYDPGARFRARE 452
+L + ++R E
Sbjct: 1042 RLQERERQYREEE 1054
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/222 (27%), Positives = 102/222 (45%), Gaps = 28/222 (12%)
Query: 219 EYIKNRKLEKQRIREEKREERRRREL---EKKRLREE-EKRRRREEERCKKKETDKQKKI 274
E ++ + EK+R +E++R+ R +L E++ LREE EKRRR+E ER +K+ KK+
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD----KKL 966
Query: 275 AEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 334
+KE ++ L ++PEK EK EE+ ++E K R E
Sbjct: 967 QQKEEQL-LGEEPEKRRRQEREKKYREEEELQQ---EEEQLLREEREKRRRQE------W 1016
Query: 335 ETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 394
E + D+ ++ E+ +E E +R R R + E E L + E+EQ G+
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQ----ERERQYREEEEL--QQEEEQLL----GE 1066
Query: 395 DRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDR 436
+R + Q+ E L + + P K R ++R
Sbjct: 1067 ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/245 (22%), Positives = 116/245 (47%), Gaps = 21/245 (8%)
Query: 196 ETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKR 255
ET E E + ++L + E + E++R ++E+RE++ RRE E++R E+ +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR--EQRLK 520
Query: 256 RRREEERCKKK-ETDKQKKIAEKEVRIKLLKKPEK---GEEPTTEKPKERGEEIDTGGGK 311
R+ EEER +++ +++Q + ++E R +LLK+ E+ +E ++ K EE K
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 312 QESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRA 371
+E + R E+ + +E +E+ + +E +R ++ RR +
Sbjct: 581 REE-------ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL 633
Query: 372 HHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERL 431
E+ RR + +R + + R K+ ++ ERL + + + R++ L
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEE--------ERLEQRLKREHEEERREQEL 685
Query: 432 ANKDR 436
A +++
Sbjct: 686 AEEEQ 690
Score = 53.1 bits (126), Expect = 5e-07
Identities = 47/170 (27%), Positives = 79/170 (46%), Gaps = 12/170 (7%)
Query: 227 EKQRIREEKREERRRRELEKKRLREEEKRRRREEER----CKKKETDKQKKIAEKEVRIK 282
EKQ E++ +RR EL ++R +E+ RR EE CK ET++ E+ R +
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD-EEQLRRRE 214
Query: 283 LLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSD 342
LL+ KG E ++ +ER + + ++E V++ + EEPQ +
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 343 KEH-----RDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 387
+E R R + QE E Q+ + ++ R E ER R ++E+R
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQEERR 322
Score = 52.4 bits (124), Expect = 9e-07
Identities = 60/255 (23%), Positives = 119/255 (46%), Gaps = 23/255 (9%)
Query: 188 EEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKK 247
E++ + L E E + RE RR L R+ + +R ++ +RE++ RRE + +
Sbjct: 354 EQEEERREQQLRREQEEERREQQLRREQQL-----RREQQLRREQQLRREQQLRREQQLR 408
Query: 248 RLRE--EEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEI 305
R ++ E++ RRE++ +++E ++ ++ E+E R + LK+ E+ E K +E E
Sbjct: 409 REQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR-EQEERRDWLKREEETERH 467
Query: 306 DTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDD 365
+ KQ+ R E EE +E ++E R+ + +EQ+ ++ +
Sbjct: 468 EQERRKQQ--------LKRDQE---EERRERWLKLEEEERREQQERREQQLRREQEERRE 516
Query: 366 GRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPA 425
R R E ERL +R EQ+ + + R + ++ + +E+ R QR
Sbjct: 517 QRLKR-QEEEERLQQRLRSEQQLRREQEERREQLLKREE---EKRLEQERREQRLKREQE 572
Query: 426 PRKERLANKDRPALQ 440
R+++L ++ Q
Sbjct: 573 ERRDQLLKREEERRQ 587
Score = 50.8 bits (120), Expect = 3e-06
Identities = 61/303 (20%), Positives = 132/303 (43%), Gaps = 26/303 (8%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
++K K++ + E + + ++ + EEE+ + E E + + R
Sbjct: 1389 ERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKF 1448
Query: 218 LEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEK 277
LE + ++L ++R R+ + EE+ +E E+++L +E+ R+ EE + + ++ +K E+
Sbjct: 1449 LE--EEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQ 1506
Query: 278 EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETS 337
E+R + ++ EE + + + + + QE + R E + Q+
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFL------QEE------QQLRRQERGQQRRQDRD 1554
Query: 338 HSGSDKEHRDVERSQEQESEAQR---YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPG- 393
++E ER ++Q S +R + +++ + R E + + EDEQ+ + G
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM----EDEQQLRRQEGQ 1610
Query: 394 ----QDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFR 449
Q+R +K +D E E+ Q D + +L ++R +D +FR
Sbjct: 1611 QQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFR 1670
Query: 450 ARE 452
E
Sbjct: 1671 EEE 1673
Score = 50.1 bits (118), Expect = 4e-06
Identities = 61/251 (24%), Positives = 120/251 (47%), Gaps = 30/251 (11%)
Query: 159 KKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTR---ELIARRTT 215
+K R+ + E+ +++ + +EEE P+ E E + R + R
Sbjct: 1619 RKFREDEQLLQEREEQQLHRQERDRKFLEEE-----PQLRRQEREQQLRHDRDRKFREEE 1673
Query: 216 PLLEYIKNRKLEKQ----RIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETD-- 269
LL+ + ++L +Q + REE+ ++ RR+E E+K L+EE++ RR+E ER ++E
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEE-QQLRRQERERKFLQEEQQLRRQELERKFREEEQLR 1732
Query: 270 ---KQKKIAEKEVRIKLLK----KPEKGEEPTTEKPKER----GEEIDTGGGKQESCAPG 318
+Q+++ +E K+L+ +PE+ E+ + ++R E++ +Q+ +
Sbjct: 1733 QETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQE 1792
Query: 319 AVVKARPMEGSLE--EPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHE-- 374
+ K R E + E Q+ D ++R E + E + QR + R++RA +
Sbjct: 1793 SDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFA 1852
Query: 375 PERLSRRSEDE 385
+ SRR E E
Sbjct: 1853 TQEKSRREEQE 1863
Score = 50.1 bits (118), Expect = 4e-06
Identities = 56/244 (22%), Positives = 108/244 (44%), Gaps = 35/244 (14%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK 246
E ++ E L E + + L + E + + E+Q +E ++E+ RR+E +
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Query: 247 KRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEID 306
K L EE+ R REE++ +++E D +K E+E +L ++ E+ + + E ++ EE
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERD--RKFREEE---QLRQEREEQQLRSQESDRKFREEEQ 1802
Query: 307 TGGGKQESCAPGAVVKARPMEG-----------SLEEPQETSHSGSDKEHRDVERSQEQE 355
++E + RP + LEE ++ D+++R E+ QE
Sbjct: 1803 LRQEREEQ-------QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855
Query: 356 S---EAQRYHVDDGRRHRAHHE----PERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPG 408
E Q ++ ++ R E E + R+ ++EQR + G+ SQ+ G
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR-----HRQVGEIKSQEGKGHG 1910
Query: 409 EAME 412
+E
Sbjct: 1911 RLLE 1914
Score = 48.5 bits (114), Expect = 1e-05
Identities = 60/239 (25%), Positives = 112/239 (46%), Gaps = 26/239 (10%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
+++ RK+ K E+ E LE E+ + L E E + + + R+
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEE-ERREQQERREQQLRREQEERREQRLKRQEEE- 525
Query: 218 LEYIKNRKLEKQRIR---EEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKI 274
E ++ R +Q++R EE+RE+ +RE E+KRL E+E+R E+R K+++ +++ ++
Sbjct: 526 -ERLQQRLRSEQQLRREQEERREQLLKRE-EEKRL-EQERR----EQRLKREQEERRDQL 578
Query: 275 AEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 334
++E + + + EE ++ K EE++ +QE + + P E E Q
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKR--EEVER--LEQEERREQRLKREEPEE---ERRQ 631
Query: 335 ETSHSGSDKEHRDVE-RSQEQESEAQRYHVD------DGRRHRAHHEPERLSRRSEDEQ 386
+ S +E R + R ++QE QR + + R R H E R +E+EQ
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Score = 47.0 bits (110), Expect = 4e-05
Identities = 41/208 (19%), Positives = 90/208 (43%), Gaps = 9/208 (4%)
Query: 186 VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELE 245
+ E+ + L E + + + + R E R+ E++R ++ +ERR + L+
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Query: 246 KKR-------LREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKP 298
+++ REEE R +E R ++ + D++++ E+ ++++ ++ E+ E +
Sbjct: 449 REQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR 508
Query: 299 KERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEA 358
+E+ E + +QE + + E L QE K + QE+ +
Sbjct: 509 REQEERREQRLKRQEE--EERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566
Query: 359 QRYHVDDGRRHRAHHEPERLSRRSEDEQ 386
+ ++ R E ER +R + EQ
Sbjct: 567 LKREQEERRDQLLKREEERRQQRLKREQ 594
Score = 46.2 bits (108), Expect = 6e-05
Identities = 40/204 (19%), Positives = 91/204 (44%), Gaps = 16/204 (7%)
Query: 228 KQRIREEKREE--RRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLK 285
K+ + +++R+E +RR E ++L EE +RRR++ + +++E + ++ +EK+ R++
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 286 KPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEH 345
+ + EE ++ + + E +Q G + P E L + +E
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 346 RDVERSQEQESEAQRYHVDDGRRHRA----------HHEPERLSRRSEDEQRWGKGPGQD 395
+ +R + Q+ Q + R+ EP+R E+E++ K Q+
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 396 RGKKGSQDSGAPGEAMERLGRAQR 419
++ ++ + +RL R Q+
Sbjct: 286 LRRERQEEE----QQQQRLRREQQ 305
Score = 42.4 bits (98), Expect = 0.001
Identities = 54/261 (20%), Positives = 112/261 (42%), Gaps = 35/261 (13%)
Query: 188 EEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKK 247
E++ + L E + + + + R E R+ + +R ++ +RE++ RRE + +
Sbjct: 367 EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 248 RLREEEK------------RRRRE-EERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPT 294
R +EEE+ R +RE EER + +++ + E+E R + LK+ ++
Sbjct: 427 REQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQE----- 481
Query: 295 TEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQ 354
E+ +ER +++ +++ E L QE ++ + ++R +E+
Sbjct: 482 -EERRERWLKLEEEERREQQ---------ERREQQLRREQE------ERREQRLKRQEEE 525
Query: 355 ESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERL 414
E QR + R E+L +R E+E+R + + R K+ ++ E
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKR-EEEKRLEQERREQRLKREQEERRDQLLKREEE 584
Query: 415 GRAQRCDDSPAPRKERLANKD 435
R QR R E+ ++
Sbjct: 585 RRQQRLKREQEERLEQRLKRE 605
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 73.2 bits (178), Expect = 5e-13
Identities = 66/263 (25%), Positives = 118/263 (44%), Gaps = 24/263 (9%)
Query: 172 EDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRI 231
E D + K E E + ++ ET + + R+ R E + ++QR
Sbjct: 231 ERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRR 290
Query: 232 REEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGE 291
E RE R+RE +++R RE E+ R+RE ER +++E ++Q +E K+ E+
Sbjct: 291 TERDRETERKRERQRERERERERNRKRERERERERERERQ-----RETERDREKERERKR 345
Query: 292 EPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERS 351
+ TE +ER + G +Q R E E ++++ ++E RD +R
Sbjct: 346 KRQTEMDRERNRQTGREGRRQAE---------RERERERERDRQSAREREERE-RDRDRD 395
Query: 352 QEQESEAQRYHVDDGRRHRAHHEPERLSRRSED-EQRWGKGPGQDRGKKGSQDSGAPGEA 410
+++E E Q DG+R E E+ R +D E G+ G++R K+ ++ +
Sbjct: 396 RQKERERQTEKDRDGQR-----ETEKQREREKDRESERGRERGREREKQKGRERDRERQT 450
Query: 411 MERLGRAQRCDD---SPAPRKER 430
+ GR ++ +P PR R
Sbjct: 451 DRQAGRQRKRSTLYVNPPPRTAR 473
Score = 72.0 bits (175), Expect = 1e-12
Identities = 60/234 (25%), Positives = 109/234 (46%), Gaps = 23/234 (9%)
Query: 222 KNRKLEKQRIREEKREER---RRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 278
+NR+ E++R RE+++ ER R+RE +++ R ++ R RE +R ++KE ++Q E++
Sbjct: 56 RNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTD-RERD 114
Query: 279 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGA-------VVKARPMEGSLE 331
+ + + +K E TE+ ERG + T G ++ A + R +
Sbjct: 115 RQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERN 174
Query: 332 EPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPE------RLSRRSEDE 385
+E + +E R+ ER +E+E++ + H + GR E E R + R D
Sbjct: 175 RQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDR 234
Query: 386 QRWGKGPGQDRGKKGSQDSGAPGEA---MERLGRAQRCDDSPAPRKERLANKDR 436
QR + ++R K+ ++ + E ER R D +KER DR
Sbjct: 235 QRKTE---REREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR 285
Score = 68.9 bits (167), Expect = 9e-12
Identities = 46/178 (25%), Positives = 85/178 (47%), Gaps = 15/178 (8%)
Query: 222 KNRKLEKQRIREEK------------REERRRRELEKKRLREEEKRRRREEERCKKKETD 269
+NR+ E++R E + RE R+R+ EK+R R+ ++ R+R+ ER ++KE +
Sbjct: 121 RNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERE 180
Query: 270 KQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGS 329
++K E+ R + +K K E+ +E+ +ER E +T + E+ + R +
Sbjct: 181 REKNRQERRERERQREKENKTEDRHSERGRERERERET---ETETERKRQTDRERDRQRK 237
Query: 330 LEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 387
E +E R+ ER +E+E E R D R+ + +R +R + R
Sbjct: 238 TEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR 295
Score = 67.0 bits (162), Expect = 4e-11
Identities = 65/260 (25%), Positives = 114/260 (43%), Gaps = 27/260 (10%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK-----KIAE 276
+ R EK+R R+ RE R+RE E+ R +E E+ RE ER + ++TD Q+ + AE
Sbjct: 97 RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156
Query: 277 KEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 336
KE + ++ ++ E +K +ER + +QE + R + E E
Sbjct: 157 KERERQTDRERQRQTERNRQKEREREK------NRQER-------RERERQREKENKTED 203
Query: 337 SHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDR 396
HS + R+ ER +E E+E +R D R R +++E E+ + +D+
Sbjct: 204 RHS---ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDK 260
Query: 397 GKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGN 456
++ +D + ++ R ++ D R ER +R + R R RE N
Sbjct: 261 ERERERDRDRDRDRRQK-ERERQTDRKRQRRTERDRETERKRER-----QRERERERERN 314
Query: 457 RRICKAEGSGTGPEKREEAE 476
R+ + E++ E E
Sbjct: 315 RKRERERERERERERQRETE 334
Score = 66.6 bits (161), Expect = 5e-11
Identities = 61/238 (25%), Positives = 106/238 (44%), Gaps = 19/238 (7%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRL--REEEKRRRREEERCKKKETDKQKKIAEKEV 279
+ R+ +++R R+ K E R ++ E++R RE E+ + RE ER + ++ D+++K E++
Sbjct: 224 RKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQT 283
Query: 280 RIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHS 339
K ++ E+ E TE+ +ER E + + + R E E +ET
Sbjct: 284 DRKRQRRTERDRE--TERKRERQRERERERERNRKRE-----RERERERERERQRETERD 336
Query: 340 GSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKK 399
+ R +R E + E R +GRR +A E ER R R + +DR +
Sbjct: 337 REKERERKRKRQTEMDRERNRQTGREGRR-QAERERERERERDRQSAREREERERDRDRD 395
Query: 400 GSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNR 457
++ ER R D K+R KDR + + + G R R ++ G R
Sbjct: 396 RQKE-------RERQTEKDR-DGQRETEKQREREKDRESERGRERG-REREKQKGRER 444
Score = 65.5 bits (158), Expect = 1e-10
Identities = 65/289 (22%), Positives = 122/289 (42%), Gaps = 37/289 (12%)
Query: 158 KKKLRKKDA-KTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTP 216
+++ R++DA K + D E ++ E +E + N + E + RE +
Sbjct: 147 RERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQ------ERRERERQREKENK 200
Query: 217 LLEYIKNRKLEKQRIREEKREERRRRELEKKRLR----EEEKRRRREEERCKKKETDKQK 272
+ R E++R RE + E R+R+ +++R R E E+ ++ E ER ++ET++ K
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDK 260
Query: 273 KIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE 332
+ + R + + +K E T++ ++R E D R E E
Sbjct: 261 ERERERDRDRDRDRRQKERERQTDRKRQRRTERD-----------------RETERKRER 303
Query: 333 PQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 392
+E R+ ER +E+E E QR + R R + R++E ++ +
Sbjct: 304 QRERERERERNRKRERERERERERERQR----ETERDREKERERKRKRQTEMDRERNRQT 359
Query: 393 GQDRGKKGSQDSGAPGE-----AMERLGRAQRCDDSPAPRKERLANKDR 436
G++ ++ ++ E A ER R + D +ER KDR
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDR 408
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 72.8 bits (177), Expect = 6e-13
Identities = 67/234 (28%), Positives = 112/234 (47%), Gaps = 39/234 (16%)
Query: 201 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKRE-ERRRRELEKKRLREEEKRRRRE 259
EME R+LI+R + + K + EK + +E++E E+ RRE E++R RE E RR RE
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERE-RRERE 326
Query: 260 EERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGA 319
ER +++E +K+K+ E+E ++ ++ + T E+ ++R E D
Sbjct: 327 REREREREREKEKE-RERE------RERDRDRDRTKERDRDRDRERD------------- 366
Query: 320 VVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLS 379
+ R E S + ++ S S R+ ER +E+E E +R + R R E ER
Sbjct: 367 --RDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERER-ERERERER 423
Query: 380 RRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLAN 433
R +D++R DR + +A ER ++ + A +ERL N
Sbjct: 424 EREKDKKR-------DREEDEE-------DAYERRKLERKLREKEAAYQERLKN 463
Score = 67.8 bits (164), Expect = 2e-11
Identities = 86/346 (24%), Positives = 147/346 (42%), Gaps = 46/346 (13%)
Query: 161 LRKKDAKTGSIEDDP------EYKKFLETYC-VEEEKTSANPETLLGEMEAKTRELIARR 213
+ K+D +E+D E KF +T+ +EEEK E E E + RE R
Sbjct: 259 ITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERER 318
Query: 214 TTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDK--- 270
E + R+ E++R RE+++E R RE ++ R R +E+ R R+ ER + ++ ++
Sbjct: 319 ERERRE--REREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSD 376
Query: 271 ----------------QKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQES 314
+++ E+E + ++ E+ E E+ +ER E D ++E
Sbjct: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436
Query: 315 CAPGAVVKARPMEGSLEEPQETSHSG-SDKEHRDVERSQEQESEAQRYHVDDGRRHRAHH 373
+ R +E L E + + E R+ ++++E E EA+R ++ RR
Sbjct: 437 --EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAER---EEERRREMAK 491
Query: 374 EPERLSRRSEDEQRWGKGPGQDRG---KKGSQDSGAPGEAMERLGRAQRCDDSPAPRKER 430
E +RL ED P RG +K +D EA ER + ++ + ++R
Sbjct: 492 EAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREK--EELEEIRQR 549
Query: 431 LANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE 476
L + P DP A + E RR + PE EE E
Sbjct: 550 LLAEGHP-----DPDAELQRMEQEAERR--RQPQIKQEPESEEEEE 588
Score = 61.2 bits (147), Expect = 2e-09
Identities = 55/227 (24%), Positives = 102/227 (44%), Gaps = 24/227 (10%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE--- 278
++R EK R RE +RE R RE E++R RE E+ R RE ER +++E DK++ E E
Sbjct: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
Query: 279 -VRIKLLKKPEKGEEPTTEKPK-------ERGEEIDTGGGKQESCAPGAVVKARPMEGSL 330
R KL +K + E E+ K ++ E + ++E +A+ ++ L
Sbjct: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500
Query: 331 E-------EPQETSHSGSDKEHRDVER---SQEQESEAQRYHVDDGRRH---RAHHEPER 377
E +P+ S K RD E+ + E++ + ++ +++ R+ H +P+
Sbjct: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDA 560
Query: 378 LSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSP 424
+R E E + P + + ++ E E+ ++ P
Sbjct: 561 ELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEP 607
Score = 43.1 bits (100), Expect = 5e-04
Identities = 43/166 (25%), Positives = 72/166 (43%), Gaps = 23/166 (13%)
Query: 201 EMEAKTRELIARRTTPLLEY-IKNRKLEKQRIREEKREERRRRELEK--KRLREE----- 252
++E K RE A L + I+ RK ++ +E +REE RRRE+ K KRL+E
Sbjct: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504
Query: 253 --------------EKRRRREEERCKKKETDKQKKIAE-KEVRIKLLKKPEKGEEPTTEK 297
+KR R E+ + E D++++ E +E+R +LL + + ++
Sbjct: 505 DDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQR 564
Query: 298 PKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDK 343
++ E KQE + + + E EEP E K
Sbjct: 565 MEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 40.0 bits (92), Expect = 0.005
Identities = 46/195 (23%), Positives = 82/195 (42%), Gaps = 23/195 (11%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEE-----KTSANPETLLG---EMEAKTREL 209
K+ R+++ + ++ K+FLE Y + + + SA + L EMEA R+
Sbjct: 477 KEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERD- 535
Query: 210 IARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKR---LREEEKRRRREEERCKKK 266
+R LE I+ R L + + +R +E E++R +++E + EEE+ +K+
Sbjct: 536 -RKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKE 594
Query: 267 ETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKAR-- 324
E ++ E+E K KP T +P + + G PG
Sbjct: 595 EKREEPMEEEEEPEQKPCLKP-------TLRPISSAPSVSSASGNATPNTPGDESPCGII 647
Query: 325 -PMEGSLEEPQETSH 338
P E S ++ Q H
Sbjct: 648 IPHENSPDQQQPEEH 662
>gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo
sapiens]
Length = 437
Score = 72.4 bits (176), Expect = 8e-13
Identities = 59/188 (31%), Positives = 87/188 (46%), Gaps = 29/188 (15%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLR----EEEKRRRREEERCKKKETDKQKKIAEK 277
+ + E+ R R+++RE RR R +++R +EE+RR R ER K K+ D++++ +
Sbjct: 238 ERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSR--ERSKDKDRDRKRRSSRS 295
Query: 278 EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE----- 332
R + + +ER EE+ GGG + P A P +G E
Sbjct: 296 RERAR--------------RERERKEELRGGGG--DMAEPSEAGDAPPDDGPPGELGPDG 339
Query: 333 PQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 392
P G D++ R+ RS E E +R D R R H ER S R DE R G G
Sbjct: 340 PDGPEEKGRDRD-RERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEAR-GGGG 397
Query: 393 GQDRGKKG 400
GQD G +G
Sbjct: 398 GQDNGLEG 405
Score = 32.3 bits (72), Expect = 0.97
Identities = 84/382 (21%), Positives = 125/382 (32%), Gaps = 88/382 (23%)
Query: 171 IEDDPEYKKFLETYC--------VEEEKTSANP---ETLLGEMEAKTRELIARRTTPLLE 219
+E P K + YC E+ + + P ET ME K RE I RR +
Sbjct: 25 LEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAETREERMERKRREKIERRQQEVET 84
Query: 220 YIKN--------------RKLEKQRIREEKREERRRRELEK----KRLREEEKRR----- 256
+K + L R+ + E + RRE E KR+ +R
Sbjct: 85 ELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRREFEVYGPIKRIHMVYSKRSGKPR 144
Query: 257 -------RREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEID--- 306
E + + KKI + V + + E+G +P+ G +
Sbjct: 145 GYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDV----ERGRTVKGWRPRRLGGGLGGTR 200
Query: 307 TGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYH---- 362
GG G +R E P D+E ERS+E++ E +R
Sbjct: 201 RGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRERERRERSRERDKERERRRSRSR 260
Query: 363 -----------------------VDDGRRHRAHHEPERLSRRSE--DEQRWGKGPGQDRG 397
D R+ R+ ER R E +E R G G +
Sbjct: 261 DRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRERARRERERKEELRGGGGDMAEPS 320
Query: 398 KKGS--QDSGAPGE-------AMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARF 448
+ G D G PGE E GR + + + R ER +DR + D
Sbjct: 321 EAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSHRSERERRRDRDRDR--DRDREH 378
Query: 449 RARECGGNRRICKAEGSGTGPE 470
+ E G R +A G G G +
Sbjct: 379 KRGERGSERGRDEARGGGGGQD 400
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 70.5 bits (171), Expect = 3e-12
Identities = 65/240 (27%), Positives = 107/240 (44%), Gaps = 30/240 (12%)
Query: 200 GEMEAK-TRELIARRTTPLLEYIKNRKLEKQRIREEKREER---RRRELEKKRLREEEKR 255
GE + + RE R ++P+ +N +LE+ REE+R +R RR E ++R RE E+
Sbjct: 627 GERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERD 686
Query: 256 RRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESC 315
R RE ER ++++ +++K E+E+ + E+ E E+ KER E D
Sbjct: 687 RERERERERERDREREK---EREL------ERERAREREREREKERDRERDRDRDHDRE- 736
Query: 316 APGAVVKARPMEGSLEEPQETSHSGSDKE-HRDVERSQEQESEAQRYHVDDGRRHRAHH- 373
+ R E E+ +E ++E R+ ER +E+E E +R D R R
Sbjct: 737 ------RERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDW 790
Query: 374 ------EPERLSRRSEDEQRWGKGPGQD--RGKKGSQDSGAPGEAMERLGRAQRCDDSPA 425
+R +R E + G D + KK ++ G+P R + DS A
Sbjct: 791 EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDA 850
Score = 67.8 bits (164), Expect = 2e-11
Identities = 56/246 (22%), Positives = 111/246 (45%), Gaps = 15/246 (6%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK--KIAEKEV 279
K R+LE++R RE +RE + R+ E+ R R+ ++ R RE ER ++KE ++++ + E+E
Sbjct: 703 KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762
Query: 280 RIKLLKKPEKGEEPTTEKPKER-----GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 334
+ ++ E+ E E+ KER E+ D G + P +G E
Sbjct: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822
Query: 335 ETSH--SGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 392
+ + GS + +R +E ++ Y+ D + + H ++ R E
Sbjct: 823 KKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEK-HRLLSQVVRPQESRSLSPSHL 881
Query: 393 GQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARE 452
+DR + ++ P ER ++R ++ K +K R ++ + +R RA++
Sbjct: 882 TEDRQGRWKEEDRKP----ERKESSRRYEEQELKEKVSSVDKQREQTEILE-SSRMRAQD 936
Query: 453 CGGNRR 458
G+ +
Sbjct: 937 IIGHHQ 942
Score = 35.0 bits (79), Expect = 0.15
Identities = 18/66 (27%), Positives = 39/66 (59%), Gaps = 2/66 (3%)
Query: 219 EYIKNRKLEKQRIREEKREERRRREL--EKKRLREEEKRRRREEERCKKKETDKQKKIAE 276
++ +NR ++ R RE +RE +RR+L E++RL + R R+ +R + E+ + + +
Sbjct: 1330 DWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKR 1389
Query: 277 KEVRIK 282
E +++
Sbjct: 1390 CEAKLE 1395
Score = 32.7 bits (73), Expect = 0.74
Identities = 44/225 (19%), Positives = 86/225 (38%), Gaps = 21/225 (9%)
Query: 190 KTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRL 249
+ SA+P + ++ R +P+ E K R ++ + R RR + KR
Sbjct: 368 RRSASPYPSHSLSSPQRKQSPPRHRSPMRE--KGRHDHERTSQSHDRRHERREDTRGKRD 425
Query: 250 REEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGG 309
RE + REE ++ ++ + ++E R ++ + T +E + D
Sbjct: 426 RE---KDSREEREYEQDQSSSRDHRDDREPR----DGRDRRDARDTRDRRELRDSRDMRD 478
Query: 310 GKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERS-----QEQESEAQRYHVD 364
++ ++R S +H D+E RD R +E S + + +
Sbjct: 479 SREMRDYSRDTKESRDPRDS--RSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE 536
Query: 365 DGRRHRAHHEPERLSRRSEDEQRWGKGPGQ-----DRGKKGSQDS 404
+ R +E SR R G+ G+ ++G +GS+ S
Sbjct: 537 ESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGS 581
Score = 31.2 bits (69), Expect = 2.2
Identities = 55/277 (19%), Positives = 106/277 (38%), Gaps = 32/277 (11%)
Query: 140 KGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLL 199
+G Y + +P + + R K+ K ++ +P+ + EE + E+
Sbjct: 66 RGKGYSSNYRRSPERPTGDLRERMKN-KRQDVDTEPQKRN------TEESSSPVRKESSR 118
Query: 200 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREER----RRRELEKKRLREEEKR 255
G K I + TP E +N + E R + + LE KR + + +
Sbjct: 119 GRHREKEDIKITKERTPESEE-ENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQREL 177
Query: 256 RRREEERC-KKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQES 314
+ E+E K++E +K+++ + VR KL P +++ PK + + K++
Sbjct: 178 MKLEQENMEKREEIIIKKEVSPEVVRSKL--SPSPSLRKSSKSPKRKSSPKSSSASKKDR 235
Query: 315 CAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHE 374
K + L + Q S + K+ S +D + + E
Sbjct: 236 -------KTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIP------EDIALGKKYKE 282
Query: 375 PERLSRRSEDEQRWGKGPGQD----RGKKGSQDSGAP 407
++ R E++ R GK G+D R K+ S +P
Sbjct: 283 KYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSP 319
Score = 30.4 bits (67), Expect = 3.7
Identities = 32/170 (18%), Positives = 66/170 (38%), Gaps = 15/170 (8%)
Query: 234 EKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK---KIAEKEVRIKLLKKPEKG 290
++ +ER R E +++R RE R+RE +R K+ + + ++ E+E ++ E+
Sbjct: 1297 DRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERE------RERERD 1350
Query: 291 EEPTTEKPKER----GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEH- 345
+ ++ +ER E D + + + + E LE E + ++
Sbjct: 1351 KRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSL 1410
Query: 346 -RDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 394
D ER + Q + + E + +D G G G+
Sbjct: 1411 ALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGE 1460
Score = 30.4 bits (67), Expect = 3.7
Identities = 19/61 (31%), Positives = 32/61 (52%), Gaps = 16/61 (26%)
Query: 225 KLEKQRIREEKREERRRRELEKK------------RLREEEKRRRREEERCKKKETDKQK 272
+ E R RE +R + R+RE ++ RLRE E RE ER K+++ D+++
Sbjct: 1304 RYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERE----RERERDKRRDLDRER 1359
Query: 273 K 273
+
Sbjct: 1360 E 1360
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 67.8 bits (164), Expect = 2e-11
Identities = 67/238 (28%), Positives = 106/238 (44%), Gaps = 42/238 (17%)
Query: 221 IKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVR 280
I+ RK K+ E+++ERR RE KR RE EK R+R ER KK++ ++KK + +
Sbjct: 45 IETRKEGKKERESERKKERRERE---KRKREREKERKR--ERGKKEKKGERKKEERERKK 99
Query: 281 IKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSG 340
+ K+ ++GEE K KE+ E T +E + R E EE +E
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKEGKE--------RERKEERKREERKERERK- 150
Query: 341 SDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKG 400
KE R+ ER +++ + +R V G + E ER R+ + R ++R K+
Sbjct: 151 --KEEREKERERKERKKRERKQV--GEKEEERKEKERKERKKRERNR------KERKKE- 199
Query: 401 SQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRR 458
ER R +R +KER ++R + D +R +E G R
Sbjct: 200 ----------RERKERRER-------KKERKKKEERKKERQKDRQTNWREKERGKRER 240
Score = 61.6 bits (148), Expect = 1e-09
Identities = 48/203 (23%), Positives = 100/203 (49%), Gaps = 18/203 (8%)
Query: 200 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRRE 259
G+ E ++ RR + + ++ +++R ++EK+ ER++ E E+K+ R E++ + E
Sbjct: 51 GKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGE 110
Query: 260 EERCKKKETDKQKKIAEKEVRIKLLKKPEKGEE--PTTEKPKERGEEIDTGGGKQESCAP 317
E+ +KK+ K++ KE + + K+ K EE K +ER +E + K+
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKK----- 165
Query: 318 GAVVKARPMEGSLEEPQETSHSGSDKEHRDVERS-QEQESEAQRYHVDDGRRHRAHHEPE 376
+ R G EE ++ KE + ER+ +E++ E +R + ++ R E
Sbjct: 166 ----RERKQVGEKEEERKEKER---KERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 377 RLSRRSEDEQRWGKGPGQDRGKK 399
+ R+ + + W + ++RGK+
Sbjct: 219 KKERQKDRQTNWRE---KERGKR 238
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 2/121 (1%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
KKK +K+ +T + E K+ E E ++ E E E K R+ R+
Sbjct: 116 KKKEKKERGRTSKEGKERERKE--ERKREERKERERKKEEREKERERKERKKRERKQVGE 173
Query: 218 LEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEK 277
E + K K+R + E+ + R++E E+K RE +K R+++EER K+++ D+Q EK
Sbjct: 174 KEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREK 233
Query: 278 E 278
E
Sbjct: 234 E 234
Score = 55.1 bits (131), Expect = 1e-07
Identities = 45/149 (30%), Positives = 75/149 (50%), Gaps = 12/149 (8%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
KK+ R+K+ K G ++ + K+ E +E + E K RE R
Sbjct: 98 KKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE----RKKEE 153
Query: 218 LEYIKNRKLEKQRIRE---EKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKI 274
E + RK K+R R+ EK EER+ +E K+R + E R+ R++ER +K+ +++K+
Sbjct: 154 REKERERKERKKRERKQVGEKEEERKEKE-RKERKKRERNRKERKKERERKERRERKKER 212
Query: 275 AEKEVRIKLLKKPEKGEEPTTEKPKERGE 303
+KE R KK + + T + KERG+
Sbjct: 213 KKKEER----KKERQKDRQTNWREKERGK 237
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 66.6 bits (161), Expect = 5e-11
Identities = 47/168 (27%), Positives = 85/168 (50%), Gaps = 5/168 (2%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK-KIAEKEVR 280
++ + ++QR RE RE R RE EK+ RE E++R RE +R +++ET++++ K E +
Sbjct: 42 RHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRH 101
Query: 281 IKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHS- 339
+ ++ +K +E E+ ++R E G++ R E E +ET
Sbjct: 102 TETDRERQKQKEREMERVRDREREKQKEMGRERQTDRET---DRERERQAERERETGRER 158
Query: 340 GSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 387
++ HR+ ER +++E E +R + R E +R + R D QR
Sbjct: 159 KTEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQR 206
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/153 (24%), Positives = 76/153 (49%), Gaps = 4/153 (2%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 281
++R+ EKQ RE +R+ R R+ +++R E E+ + RE +R + + ++QK+ + R+
Sbjct: 60 RDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERV 119
Query: 282 K---LLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSH 338
+ K+ E G E T++ +R E ++ + R E + +E
Sbjct: 120 RDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179
Query: 339 SGSDKE-HRDVERSQEQESEAQRYHVDDGRRHR 370
++E H D+ER +++E++ +R + R R
Sbjct: 180 ETKERERHTDMERERQRETDRKRDRQRESERER 212
Score = 47.8 bits (112), Expect = 2e-05
Identities = 38/158 (24%), Positives = 77/158 (48%), Gaps = 18/158 (11%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
+K+ ++ + E D + ++ E +E +T + ET + K RE+
Sbjct: 65 EKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREM-------- 116
Query: 218 LEYIKNRKLEKQ----RIREEKREERRRRELEKKRLREEEKRRR-----REEERCKKKET 268
E +++R+ EKQ R R+ RE R RE + +R RE + R+ RE ER +K+E
Sbjct: 117 -ERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRER 175
Query: 269 DKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEID 306
+++++ E+E + ++ ++ + ++ +E E D
Sbjct: 176 ERKRETKERERHTDMERERQRETDRKRDRQRESERERD 213
Score = 47.4 bits (111), Expect = 3e-05
Identities = 43/209 (20%), Positives = 91/209 (43%), Gaps = 17/209 (8%)
Query: 234 EKREERRRRELEKKRL-REEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEE 292
E + E R E + + R+ E+RR + ER + KE+ + + +E++ ++ ++
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERD------RQRDRERN 55
Query: 293 PTTEKPKERGEEIDTGGGKQ-----ESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRD 347
++ +ER ++ D G +Q + + R E + ET ++ R+
Sbjct: 56 RERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKERE 115
Query: 348 VERSQEQESEAQRYHVDDGRRHRAHHEPER-LSRRSEDEQRWGK-GPGQDRGKKGSQDSG 405
+ER +++E E Q+ + GR + E +R R++E E+ G+ +DR ++ ++
Sbjct: 116 MERVRDREREKQK---EMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERK 172
Query: 406 APGEAMERLGRAQRCDDSPAPRKERLANK 434
E +R D R+ K
Sbjct: 173 RERERKRETKERERHTDMERERQRETDRK 201
Score = 46.2 bits (108), Expect = 6e-05
Identities = 30/106 (28%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 212 RRTTPLLEYIKNRKLEKQRIREEKREER----RRRELEKKRLREEEKRRRREEERCKKKE 267
R T E K ++ E +R+R+ +RE++ R R+ +++ RE E++ RE E ++++
Sbjct: 100 RHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERK 159
Query: 268 TDKQKKIAEKE-VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQ 312
T+ + + E+E R + K+ K E T+ +ER E D +Q
Sbjct: 160 TEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQ 205
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 66.2 bits (160), Expect = 6e-11
Identities = 78/319 (24%), Positives = 143/319 (44%), Gaps = 46/319 (14%)
Query: 148 VEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTR 207
+E P K A ++ R KD +++ + T +E EK + + +E R
Sbjct: 704 LEEIPLIKSAYEEQRIKDMDLWEQQEEER----ITTMQLEREKALEHKNRMSRMLE--DR 757
Query: 208 ELIARRTTPLLEYIKNRKLEK--QRIREEKR---EERRRRELEKKRL-----REEEKRRR 257
+L R + + KL++ +R+ EE+ EER+R+ E++R+ +EEE++RR
Sbjct: 758 DLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRR 817
Query: 258 REEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQES--- 314
EE+ K++E ++ + A++E ++ ++ K E K ++R EI+ ++E
Sbjct: 818 AEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERR 877
Query: 315 CAPGAVVKA------RPMEGSL----EEPQETSHSGSDK-----EHRDVERSQEQESE-A 358
++ + R EG+ E E +K E RD +RS ++ E
Sbjct: 878 LGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERP 937
Query: 359 QRYHVDDGRRHRAHHEPERLSRRSEDEQRW-GKGPGQDRGKKGSQDSGAPGEAMERLGRA 417
+R D+ R + +R+ RR D+ R +GP +DR + D P
Sbjct: 938 RRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPS--------W 989
Query: 418 QRCDDSPAPRKERLANKDR 436
+ DD PR R+A++DR
Sbjct: 990 RNTDDDRPPR--RIADEDR 1006
Score = 51.6 bits (122), Expect = 2e-06
Identities = 42/123 (34%), Positives = 66/123 (53%), Gaps = 6/123 (4%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKRE-ERRRRELE 245
+EE+ L + + ++ARR T +E K R LE I+ EK E E+R EL+
Sbjct: 546 KEEQHQLAVTAYLKNSRKEHQRILARRQT--IEERKER-LESLNIQREKEELEQREAELQ 602
Query: 246 KKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKL--LKKPEKGEEPTTEKPKERGE 303
K R EEE+ R+ +ER K++ + ++I +K VR +L +KK E G + + E E
Sbjct: 603 KVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLE 662
Query: 304 EID 306
E+D
Sbjct: 663 ELD 665
Score = 39.3 bits (90), Expect = 0.008
Identities = 59/296 (19%), Positives = 119/296 (40%), Gaps = 32/296 (10%)
Query: 154 QKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARR 213
+++ L +KD++ G + + ++K E + E PE E + + RR
Sbjct: 876 RRLGDSSLSRKDSRWGDRDSEGTWRKGPEA---DSEWRRGPPEKEWRRGEGRDEDRSHRR 932
Query: 214 TTPLLEYIKNRKLEKQRIR-EEKREERRRRELEK--KRLREEEK--RRRREEERCKKKET 268
+ + + + +R ++ R RR + ++ +R EE++ RR +++R + T
Sbjct: 933 DEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNT 992
Query: 269 DKQK---KIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK--QESCAP--GAVV 321
D + +IA+++ ++P RG + D G + E P G
Sbjct: 993 DDDRPPRRIADED--------RGNWRHADDDRPPRRGLDEDRGSWRTADEDRGPRRGMDD 1044
Query: 322 KARPMEGSLEEPQETSHSGSD----KEHRDVERSQEQ---ESEAQRYHVDDGRRHRAHHE 374
P G ++ + + + D + D +R + + R +DD R R +
Sbjct: 1045 DRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPRRGMDDDRGPRRGMDDDRGPRRGMD 1104
Query: 375 PERLSRRSEDEQR--WGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRK 428
+R RR D+ R W ++G++D P M+ ++R DD PR+
Sbjct: 1105 DDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPWRNMDDDRLSRRADDDRFPRR 1160
Score = 37.7 bits (86), Expect = 0.023
Identities = 53/241 (21%), Positives = 109/241 (45%), Gaps = 50/241 (20%)
Query: 153 FQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIAR 212
+ K ++K+ ++ A+ +IE E K+ LE+ ++ EK E+E + EL
Sbjct: 557 YLKNSRKEHQRILARRQTIE---ERKERLESLNIQREKE---------ELEQREAELQ-- 602
Query: 213 RTTPLLEYIKNRKLEKQRIREEKREERRRR------ELEKKRLREEEKRRRREE---ERC 263
K RK E++R+R+E +E + R +++KK +RE ++ ++ E +
Sbjct: 603 ---------KVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAF 653
Query: 264 KKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKA 323
K + + +++ + K +++ EK ++ E+ K + ++ID +A
Sbjct: 654 KDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKID------------YFERA 701
Query: 324 RPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSE 383
+ LEE + ++ +D++ ++QE E R R +A R+SR E
Sbjct: 702 K----RLEEIPLIKSAYEEQRIKDMDLWEQQEEE--RITTMQLEREKALEHKNRMSRMLE 755
Query: 384 D 384
D
Sbjct: 756 D 756
Score = 33.9 bits (76), Expect = 0.33
Identities = 36/182 (19%), Positives = 68/182 (37%), Gaps = 26/182 (14%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREE---------------ERCKKK 266
K R + Q E ++ R R+ E+ RE+ RR R+E + ++
Sbjct: 1207 KERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRD 1266
Query: 267 ETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPM 326
+ D+ + E++ R L ++ + ++ P R E + ++ V+ R
Sbjct: 1267 DRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDP 1326
Query: 327 EGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQ 386
+ P + S RD +R +E E E + + R E R ++ DE
Sbjct: 1327 PRRVPPP-----ALSRDRERDRDREREGEKEKASWRAEKDR------ESLRRTKNETDED 1375
Query: 387 RW 388
W
Sbjct: 1376 GW 1377
Score = 33.1 bits (74), Expect = 0.57
Identities = 49/212 (23%), Positives = 81/212 (38%), Gaps = 31/212 (14%)
Query: 236 REERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTT 295
RE+ + RE RE RE +R K+++ D Q + E ++P
Sbjct: 1179 REKEKAREESWGPPRESRPSEEREWDREKERDRDNQ-------------DREENDKDPER 1225
Query: 296 EKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQE 355
E+ +ER ++D + G + P E S + D++ R ER ++
Sbjct: 1226 ERDRER--DVDREDRFRRPRDEGG-WRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRD 1282
Query: 356 SEAQRYHVDDGRRH----RAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAM 411
+R DD R R+ E RR++D + DR ++ P A+
Sbjct: 1283 LRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRK-------DDRVEERDPPRRVPPPAL 1335
Query: 412 ERLGRAQRCDDSPAPRKERL---ANKDRPALQ 440
R R + D KE+ A KDR +L+
Sbjct: 1336 SR-DRERDRDREREGEKEKASWRAEKDRESLR 1366
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 65.9 bits (159), Expect = 8e-11
Identities = 62/223 (27%), Positives = 113/223 (50%), Gaps = 22/223 (9%)
Query: 144 YPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEME 203
+P+ + A +I K++ R++ + ++E + ++ E +EE++ +A E L +
Sbjct: 432 FPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERR-MEEQRKAACAEKL----K 486
Query: 204 AKTRELIARRTTPLLEYIKNRKLEKQRIR----EEKREERRRRELEKKRLREEEKRRRRE 259
+L P E I+ R+ EK+R R E+++E+ R +E EK R R++EK + E
Sbjct: 487 RLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELE 546
Query: 260 EERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGA 319
+E+ K++E +K++K EKE ++ K+ EK + E+ KE E++ K E
Sbjct: 547 KEQEKQREMEKERK-QEKEKELERQKEKEKELQKMKEQEKEC--ELEKEREKLEE----- 598
Query: 320 VVKARPMEGSLE---EPQETSHSGSDKEHRDVERSQEQESEAQ 359
K P E +LE E QE+ +S + +E R SE +
Sbjct: 599 --KIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKE 639
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/172 (25%), Positives = 84/172 (48%), Gaps = 15/172 (8%)
Query: 228 KQRIREEKR--EERRRRE------LEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEV 279
KQ++ +E ++RRR++ +E+ R R EE+ RR EE+R K +K K++ EK
Sbjct: 435 KQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQR-KAACAEKLKRLDEKLG 493
Query: 280 RIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQ-----ESCAPGAVVKARPMEGSLEEPQ 334
++ PE+ E EK +ER +E++ ++ E K + +E E+ +
Sbjct: 494 ILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQR 553
Query: 335 ETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQ 386
E ++ +++ER +E+E E Q+ + + E E+L + E +
Sbjct: 554 EMEKERKQEKEKELERQKEKEKELQKMK-EQEKECELEKEREKLEEKIEPRE 604
Score = 31.6 bits (70), Expect = 1.6
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 11/117 (9%)
Query: 185 CVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQ---RIREEKREERRR 241
C++ ++ PE + K I P E + K E + R +REE
Sbjct: 953 CIDSKEPIERPEE-----KPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVND 1007
Query: 242 RELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKP 298
R + + ++ R +EER ++KE + +K AEK V K++ KPEK E+ P
Sbjct: 1008 RPVRRSGPIKKPVLRDMKEEREQRKEKEGEK--AEK-VTEKVVVKPEKTEKKDLPPP 1061
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 65.1 bits (157), Expect = 1e-10
Identities = 59/277 (21%), Positives = 123/277 (44%), Gaps = 16/277 (5%)
Query: 163 KKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIK 222
KKD K G+ E D + +E + S +P +++ ++ ++
Sbjct: 241 KKDGKEGAEEID----RHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELE 296
Query: 223 NRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIK 282
K E+QR+ E +E + R + R E+RR R ER + + + +K ++ +
Sbjct: 297 REK-ERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRE 355
Query: 283 LLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSD 342
K+ E+G + KERG E + + + K + G +EE ++ D
Sbjct: 356 REKENERGRRRDRDYDKERGNEREKERERSRERS-----KEQRSRGEVEE-KKHKEDKDD 409
Query: 343 KEHRDVERSQEQESEAQRYHVDDGR---RHRAHHEPERLSRRSEDEQRWGKGPGQDRGKK 399
+ HRD +R ++E + R + + R R+ + +R RS+++ K +++ K
Sbjct: 410 RRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNK 469
Query: 400 GSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDR 436
S+ SG+ G + + ++++ + SP+ K R ++ +
Sbjct: 470 RSR-SGSQGRT-DSVEKSKKREHSPSKEKSRKRSRSK 504
Score = 47.4 bits (111), Expect = 3e-05
Identities = 44/167 (26%), Positives = 77/167 (46%), Gaps = 26/167 (15%)
Query: 224 RKLEKQRIREEKREERRRRELEKKRLREE--------EKRRRREEE-------RCKKKET 268
R+ E++R RE +E+R R E+E+K+ +E+ +KR ++E+ R +K +
Sbjct: 378 REKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRS 437
Query: 269 DKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTG------GGKQESCAPGAVVK 322
+ + A K R + +K K + + EK +R G K+ +P + K
Sbjct: 438 RSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSP-SKEK 496
Query: 323 ARPMEGSLEEPQETSHSG----SDKEHRDVERSQEQESEAQRYHVDD 365
+R S E + HS SDK R +S EQES+ +++ D
Sbjct: 497 SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
Score = 38.9 bits (89), Expect = 0.010
Identities = 30/128 (23%), Positives = 51/128 (39%), Gaps = 10/128 (7%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 281
K +K + R RE K R R KR R K + + + K++++K+ + +
Sbjct: 421 KEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTD 480
Query: 282 KLLKKPEKGEEPTTEKP------KERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQE 335
+ K ++ P+ EK KER + D K +S R + +E QE
Sbjct: 481 SVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKH----DRRRSQSIEQESQE 536
Query: 336 TSHSGSDK 343
H D+
Sbjct: 537 KQHKNKDE 544
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 65.1 bits (157), Expect = 1e-10
Identities = 71/285 (24%), Positives = 122/285 (42%), Gaps = 46/285 (16%)
Query: 196 ETLLGEMEAKTRELIARRTTPLLEYIKNRK-LEKQRIRE------EKREERRRRELEKKR 248
E L E E R+L+A R + + + R+ LE+Q+ RE ++RE+RRR + EK+R
Sbjct: 378 EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRR 437
Query: 249 LREEEKRRRREEERCKKKETDK---------QKKIAEKEVRIKLLKKPEKGEEPT----- 294
L E E+RR+ EEER + +E + ++++ E++ +++L++ E+
Sbjct: 438 LEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDH 497
Query: 295 -------TEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRD 347
+++P +E K AP P + + E P T+ RD
Sbjct: 498 RRPHPQHSQQPPPPQQE----RSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRD 553
Query: 348 --VERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSED-EQRWGKGPGQDRGKKGSQDS 404
++ S +Q S+A + R + EP L R E R G G GSQ
Sbjct: 554 SPLQGSGQQNSQAGQ------RNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPG 607
Query: 405 GAPGEAME-----RLGRAQRCDDSPAPRKERLANKDRPALQLYDP 444
PG R+ + + + SP+ R E K +++ P
Sbjct: 608 SHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRP 652
Score = 48.5 bits (114), Expect = 1e-05
Identities = 67/291 (23%), Positives = 119/291 (40%), Gaps = 30/291 (10%)
Query: 201 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREE 260
+ E K R RR L E + E +R +R++R ++ E++R EE++RR RE
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 261 ERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEP--TTEKPKERGEEIDTGGGKQESCAPG 318
R ++E +++++ E++ R++ L++ K EE E+ K R E +QE
Sbjct: 420 RR--QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVER------EQEYIRRQ 471
Query: 319 AVVKARPMEGSLEEPQET------SHSGSDKEHRDVERSQEQESEAQRYHVDDGRRH--- 369
+ R +E ++ + H +H +QE +H + + H
Sbjct: 472 LEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEP 531
Query: 370 --RAHHEPERLSRRSEDEQRWG---KGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSP 424
RA P R + RS R +G GQ + G ++S + E R ++ P
Sbjct: 532 ADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKL--VP 589
Query: 425 APRKERLANKDRPALQLYDPGARFRARECGGNR-RICKAEGSGTGPEKREE 474
P + Q PG+ ++ G R R+ + S P +R E
Sbjct: 590 RPGSGSSSGSSNSGSQ---PGSHPGSQSGSGERFRVRSSSKSEGSPSQRLE 637
Score = 45.1 bits (105), Expect = 1e-04
Identities = 50/222 (22%), Positives = 92/222 (41%), Gaps = 28/222 (12%)
Query: 226 LEKQRIREEKREERRRRELEKKRLREEEKRRRREE-------ERCKKKETDKQ--KKIAE 276
L + +R ++ + R L +++L +E++ R +EE ER K+ E K+ +++ E
Sbjct: 352 LRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEE 411
Query: 277 KEVRIKLLKKPEKGEEPTTE-KPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQE 335
++ R + ++ ++ E+ E + K R EE++ ++E K R +E QE
Sbjct: 412 QQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR-----VEREQE 466
Query: 336 TSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQD 395
++E R +E Q+Q + Q + D RR H + P Q
Sbjct: 467 YIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQ-------------PPPPQQ 513
Query: 396 RGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRP 437
K S + P E RA+ R L+ +D P
Sbjct: 514 ERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSP 555
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 63.9 bits (154), Expect = 3e-10
Identities = 49/183 (26%), Positives = 88/183 (48%), Gaps = 13/183 (7%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKI------- 274
K ++ + R RE++ E R RE EK++ RE E+ R RE ER + +E +++++
Sbjct: 105 KEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQ 164
Query: 275 AEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQ---ESCAPGAVVKARPMEGSLE 331
E E + ++ EK +E TE+ ++R + + +Q E R E E
Sbjct: 165 RETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDRE 224
Query: 332 EPQETSHSGSDKEHRD--VERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR-W 388
+ET + RD ER +E++ + +R R + E ++ +R ED++R W
Sbjct: 225 GERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKW 284
Query: 389 GKG 391
G+G
Sbjct: 285 GEG 287
Score = 60.5 bits (145), Expect = 3e-09
Identities = 53/209 (25%), Positives = 95/209 (45%), Gaps = 30/209 (14%)
Query: 223 NRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIK 282
+R+ E+ R+RE+ +ER R ++KR RE RRR+E+E + ++ +KQ +I R K
Sbjct: 76 DRQRERDRVREKTEKERDR---DRKRDRE---RRRKEKETNRNRDREKQTEIERDREREK 129
Query: 283 LLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSD 342
+KG E ++ +ER + D + + E E+ ++
Sbjct: 130 -----QKGRERERDRGRERERDRD---------------REKERERQTEKDRDGQRETET 169
Query: 343 KEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ-DRGKKGS 401
+ RD ER +++E E +R D R+ E ER + R D QR + Q + ++G
Sbjct: 170 ERERDREREKQKERETER---DRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGE 226
Query: 402 QDSGAPGEAMERLGRAQRCDDSPAPRKER 430
+++ E R + D ++ER
Sbjct: 227 RETDRRRERQRDRDRGKERDRERDRKEER 255
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 201 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIRE---EKREERRRRELEKKRLREEEKRRR 257
+ + KT+ R T E +R+ E+QR R+ E+ ER R+E KK ++E K+ R
Sbjct: 208 DRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKER 267
Query: 258 REEERCKKKETDKQKKIAE 276
+E+++ +K+ DK++K E
Sbjct: 268 KEKKKEEKRREDKKRKWGE 286
Score = 43.1 bits (100), Expect = 5e-04
Identities = 37/137 (27%), Positives = 69/137 (50%), Gaps = 6/137 (4%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLG---EMEAKTRELIARRT 214
+++ +KD + G E + E ++ E +E +T + + E E +T R+
Sbjct: 153 RERQTEKD-RDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQR 211
Query: 215 TPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKI 274
E + E +R + +RE +R R+ K+R RE +++ R++ER KKE K++K
Sbjct: 212 KTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKER--KKERKKERKE 269
Query: 275 AEKEVRIKLLKKPEKGE 291
+KE + + KK + GE
Sbjct: 270 KKKEEKRREDKKRKWGE 286
Score = 29.6 bits (65), Expect = 6.3
Identities = 34/135 (25%), Positives = 53/135 (39%), Gaps = 26/135 (19%)
Query: 328 GSLEEPQE----TSHSGSDKEHRDVERS---QEQESEAQRYHVDDGRRHRAHHEPER--- 377
GS E P+ +H +D + R ER ++ E E R D R R E R
Sbjct: 55 GSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRD 114
Query: 378 ------LSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGR---AQRCDDSPAPR- 427
+ R E E++ G+ +DRG++ +D E + + QR ++ R
Sbjct: 115 REKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERD 174
Query: 428 ------KERLANKDR 436
KER +DR
Sbjct: 175 REREKQKERETERDR 189
>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 285
Score = 63.9 bits (154), Expect = 3e-10
Identities = 58/244 (23%), Positives = 117/244 (47%), Gaps = 27/244 (11%)
Query: 224 RKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKK-----IAEKE 278
R+ E+QR RE +R+ + R EK R E+++ R+R+ +R +++ D+ +K ++E
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRE 117
Query: 279 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSH 338
+ ++ E+ + EK +ER + + G + K R +E + +E
Sbjct: 118 TETERQEERERQRDRKREKDRERQRQREIG-----------IDKDREIETEKDRDRE-RE 165
Query: 339 SGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRW-GKGPGQDRG 397
G + +RD ER ++++ E +R + +R + E +R ++ ++ R+ + G+DR
Sbjct: 166 MGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRD 225
Query: 398 KKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKD----RPALQLYDPGARFRAREC 453
K+ ++ + + R + D P + + D R + + D G R RARE
Sbjct: 226 KERDRER----QREKDRDRQKAIDCVPGRWEVTVMAVDCVPGRWEVTVGD-GRRLRAREV 280
Query: 454 GGNR 457
GG+R
Sbjct: 281 GGDR 284
Score = 56.6 bits (135), Expect = 5e-08
Identities = 46/180 (25%), Positives = 84/180 (46%), Gaps = 15/180 (8%)
Query: 154 QKIAKKKLRKKDAKTGSIED-----DPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRE 208
+K AK++ R+KD + D D E +++ + E + ET E + R+
Sbjct: 70 RKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQEERERQ 129
Query: 209 LIARRTTPL-------LEYIKNRKLEKQRIREEKRE---ERRRRELEKKRLREEEKRRRR 258
+R + K+R++E ++ R+ +RE R R+ E++R ++ E RR R
Sbjct: 130 RDRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDR 189
Query: 259 EEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPG 318
+ ER ++KE ++ + +KE ++ E G + E+ +ER E D K C PG
Sbjct: 190 DRERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKDRDRQKAIDCVPG 249
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 63.2 bits (152), Expect = 5e-10
Identities = 63/261 (24%), Positives = 114/261 (43%), Gaps = 38/261 (14%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
++K+++++ K I + E + E E+E+ E ++ E E K REL + +
Sbjct: 301 EEKIQEQEEK---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEK----M 353
Query: 218 LEYIKNRKLEKQRIREEK-REERRRRELEKKRLREEEKRRR-----REEERCKKKETDK- 270
E K R+ E++R EEK RE+ +R+E E K R+EEK R RE+E +++ +K
Sbjct: 354 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKM 413
Query: 271 ------------------------QKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEID 306
++KI E+E +I+ ++ + +E ++ +E+ E +
Sbjct: 414 GEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQE 473
Query: 307 TGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDG 366
+QE+ K R E + E ++ +K E QEQE +
Sbjct: 474 GKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMC 533
Query: 367 RRHRAHHEPERLSRRSEDEQR 387
+ E E RR E++ R
Sbjct: 534 EQEEKMQEQEEKMRRQEEKMR 554
Score = 62.8 bits (151), Expect = 7e-10
Identities = 59/223 (26%), Positives = 109/223 (48%), Gaps = 22/223 (9%)
Query: 224 RKLEKQRIREEK---REERRRRELEKKRLREE-----EKRRRREEERCKKKETDKQKKIA 275
R+ EK + REEK +EE+ R + EK R +EE E++ RR+EE +KE +K +++
Sbjct: 292 RQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE-EKIRELE 350
Query: 276 EK-EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 334
EK + K+ ++ EK +E + +E+ +E + +QE K R E + E +
Sbjct: 351 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-------KIREQEEKIREQE 403
Query: 335 ETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 394
E +K E+ EQE E Q R+ E E+ R E++ R + Q
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 463
Query: 395 DRGKK-GSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDR 436
++ +K G Q+ G+ E+ + Q ++ ++E++ +++
Sbjct: 464 EQEEKMGEQE----GKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Score = 53.5 bits (127), Expect = 4e-07
Identities = 56/234 (23%), Positives = 112/234 (47%), Gaps = 26/234 (11%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTREL--IARRTT 215
++K+R+++ K E E +K E +E E + E E K RE + +
Sbjct: 356 QEKIREQEEKRQEEEKIREQEKRQE-----QEAKMWRQEEKIREQEEKIREQEEMMQEQE 410
Query: 216 PLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKE---TDKQK 272
+ + + E++ +E+ E+ RR+E +++RE+EK+ R +EE+ +++E ++++
Sbjct: 411 EKMGEQEEKMWEQEEEMQEQEEKMRRQE---EKIREQEKKIREQEEKIREQEEMMQEQEE 467
Query: 273 KIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE 332
K+ E+E K+ ++ K +E EK + + E+I +QE K R E ++E
Sbjct: 468 KMGEQEG--KMCEQEAKMQE-QEEKMRRQEEKI----REQEKKIREQEEKIREQEEMMQE 520
Query: 333 PQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQ 386
+E +K E+ QEQE + +R + + + RL ++ E Q
Sbjct: 521 QEEKMWEQEEKMCEQEEKMQEQEEKMRR------QEEKMREQEVRLRQQEEKMQ 568
Score = 47.4 bits (111), Expect = 3e-05
Identities = 49/214 (22%), Positives = 101/214 (47%), Gaps = 42/214 (19%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
++K+R+++ K I + E + E E+E+ E + E E K R R+ +
Sbjct: 389 EEKIREQEEK---IREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMR----RQEEKI 441
Query: 218 LEYIKNRKLEKQRIREEKR----EERRRRELEKK------RLREEEKRRRREEERCKKKE 267
E K + ++++IRE++ +E + E E K +++E+E++ RR+EE+ +++E
Sbjct: 442 REQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQE 501
Query: 268 TDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPME 327
KKI E+E +I+ + EE E+ ++ E+ +++ C E
Sbjct: 502 ----KKIREQEEKIR------EQEEMMQEQEEKMWEQ------EEKMC---------EQE 536
Query: 328 GSLEEPQETSHSGSDKEHRDVERSQEQESEAQRY 361
++E +E +K R ++QE + Q +
Sbjct: 537 EKMQEQEEKMRRQEEKMREQEVRLRQQEEKMQEH 570
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 62.8 bits (151), Expect = 7e-10
Identities = 73/319 (22%), Positives = 139/319 (43%), Gaps = 36/319 (11%)
Query: 149 EFAPFQKIAKKKLRKKDAKTGSIE-DDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTR 207
E + +K+ ++ + +A+ +E ++ E K + + +E+ E E + R
Sbjct: 250 EISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERR 309
Query: 208 ELIARRTTPLLEYIKNRKLEKQRIREEKR----------EERRRRELEKKRLREEEKR-- 255
E A + E K E+QRI+EE++ EE +R E++R++EEEKR
Sbjct: 310 E--AEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 367
Query: 256 ------RRREEERCKKKETDKQKKIAEK-----EVRIKLLKKPEKGEEPTTEKPKERGEE 304
R EEE+ K +E + K++ EK E +IK K +K E + K + ++
Sbjct: 368 EERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDK 427
Query: 305 IDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRY-HV 363
+ T K++ G V+A+ L+E + T K+ + +++ +E + E + +
Sbjct: 428 LQTAVLKKQGEEKGTKVQAK--REKLQEDKPTFKKEEIKDEK-IKKDKEPKEEVKSFMDR 484
Query: 364 DDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAP----GEAMERLGRAQR 419
G E ++ + + + PG + GAP G+ +E L R R
Sbjct: 485 KKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR--R 542
Query: 420 CDDSPAPRKERLANKDRPA 438
++ + E+L K + A
Sbjct: 543 RGETESEEFEKLKQKQQEA 561
Score = 49.7 bits (117), Expect = 6e-06
Identities = 68/321 (21%), Positives = 136/321 (42%), Gaps = 43/321 (13%)
Query: 154 QKIAKKKLRKK--DAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIA 211
++ +++LR+K + G + D E + EE KT+ + G+ EA E +A
Sbjct: 43 RRARQERLRQKQEEESLGQVTDQVEVNA-QNSVPDEEAKTTTTNTQVEGDDEAAFLERLA 101
Query: 212 RRTTPLLEYIKNRKLEKQRIREEKRE------------ERRRRELEKKRLREEEKRRRRE 259
RR E + ++L++ R+++ + R + + + E+E++
Sbjct: 102 RR-----EERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESR 156
Query: 260 EERCKKKETDKQKKI--------AEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK 311
+ER + +ET+ K AE+ + K+ E+ E+P E E+
Sbjct: 157 QERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKT 216
Query: 312 QESCAPGAVVKARPMEGSLEEP--QETSHSGSDK--EHRDVERSQEQESEAQRYHVDDGR 367
ES V+ + + S EEP +E GSD+ H +E ++ +EA+R ++
Sbjct: 217 TESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEE 276
Query: 368 RHRAHHEPERL----SRRSEDEQRWGKGPGQDRGKKGSQDSGAPGE----AMERLGRAQR 419
R R E ++ R E E+ K Q+R ++ +++ E A E R +
Sbjct: 277 RERIKAEQDKKIADERARIEAEE---KAAAQERERREAEERERMREEEKRAAEERQRIKE 333
Query: 420 CDDSPAPRKERLANKDRPALQ 440
+ A ++R+ +++ A +
Sbjct: 334 EEKRAAEERQRIKEEEKRAAE 354
Score = 49.3 bits (116), Expect = 8e-06
Identities = 35/110 (31%), Positives = 64/110 (58%), Gaps = 8/110 (7%)
Query: 200 GEMEAKTRELIARRTTPL---LEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRR 256
GE E++ E + ++ LE +K ++ E++++ EE+ + R++ E ++K EEEKRR
Sbjct: 544 GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRR 603
Query: 257 RREE-ERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEP--TTEKPKERGE 303
+EE ER + + +K++K+ E + KKP K P ++ K +ER E
Sbjct: 604 LKEEIERRRAEAAEKRQKMPEDGLSDD--KKPFKCFTPKGSSLKIEERAE 651
Score = 48.1 bits (113), Expect = 2e-05
Identities = 48/232 (20%), Positives = 98/232 (42%), Gaps = 16/232 (6%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEY-----IKNRKLEKQRIREEKREERRR 241
EEE+ +GE + + ++ +TT E +KN ++ + ++E+ E+
Sbjct: 191 EEEEEEKPKRGSIGENQVEV--MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGS 248
Query: 242 RELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKER 301
E+ EEE + R E ER + + ++++ AE++ +I + + EE + +ER
Sbjct: 249 DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERER 308
Query: 302 GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRY 361
E + ++E A + R E +E +++ ER + +E E +
Sbjct: 309 REAEERERMREEE-KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 367
Query: 362 HVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMER 413
R RA E E ++ E + + + K Q++ GE +E+
Sbjct: 368 E----ERQRARAEEEEKAKVEEQK----RNKQLEEKKHAMQETKIKGEKVEQ 411
Score = 45.8 bits (107), Expect = 8e-05
Identities = 40/163 (24%), Positives = 76/163 (46%), Gaps = 15/163 (9%)
Query: 154 QKIAKKKLRKK------DAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTR 207
+KI K K K+ D K G E + +F+ E T + P G T+
Sbjct: 466 EKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPG---GRASVDTK 522
Query: 208 ELIARRTTPL---LEYIKNRKLEKQRIREEKREERRRR---ELEKKRLREEEKRRRREEE 261
E LE ++ R+ E + EK +++++ ELE+ + + EE+R+ EEE
Sbjct: 523 EAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEE 582
Query: 262 RCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEE 304
++K+ + +K+ E+E + +L ++ E+ EK ++ E+
Sbjct: 583 EQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPED 625
Score = 45.4 bits (106), Expect = 1e-04
Identities = 32/111 (28%), Positives = 56/111 (50%), Gaps = 9/111 (8%)
Query: 186 VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELE 245
V+ ++ P+ G+ + EL RR E + K ++Q E E +++RE
Sbjct: 519 VDTKEAEGAPQVEAGK---RLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREER 575
Query: 246 KKRLREEEKRRRREEERCKKKETDKQKKIAEK------EVRIKLLKKPEKG 290
+K L EEE+RR++EE K +E ++++++ E+ E K K PE G
Sbjct: 576 RKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDG 626
Score = 39.7 bits (91), Expect = 0.006
Identities = 41/204 (20%), Positives = 89/204 (43%), Gaps = 25/204 (12%)
Query: 219 EYIKNRKLEKQRIREEKREERRRRELEKKRLREEE----KRRRREEERCKKKETDKQKKI 274
++ + R+L +Q+ REE R E R ++ EEE +RRR +ER ++K+ ++
Sbjct: 3 DFERRRELRRQK-REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 275 AEKEVRIKLLKK-PEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP 333
+V + P++ + TT + G D E A + + ++ +LE
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEG---DDEAAFLERLARREERRQKRLQEALERQ 118
Query: 334 QETSHSGSD--------------KEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPE--R 377
+E + +D E+ E+ ++ ES +RY +++ ++ R
Sbjct: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
Query: 378 LSRRSEDEQRWGKGPGQDRGKKGS 401
+ ++ E + + +++ K+GS
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGS 202
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 62.4 bits (150), Expect = 9e-10
Identities = 45/182 (24%), Positives = 89/182 (48%), Gaps = 10/182 (5%)
Query: 218 LEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEK 277
+E + RK E R +E +RE R+RE E + R E + R+R+ R + ++TD++K+ E+
Sbjct: 1 MERQRERKRETDRGKETERERDRQRERENQTER-ENRHRQRDRHRERDRQTDREKE-RER 58
Query: 278 EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETS 337
+ ++ E+ E TE+ +ER + + K+++ + R + + +E +
Sbjct: 59 QKERDRQRQRERETERETERQRERQRQRER---KRQTDRERDKDRDRERKRETDRNRERN 115
Query: 338 HSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRG 397
G + + ER +++E E QR + +R R ER + QRW + + +
Sbjct: 116 RKGGRERDKQTERERDRERERQRQRERERQRQR-----ERKRETDRERQRWAEREERKKE 170
Query: 398 KK 399
+K
Sbjct: 171 RK 172
Score = 62.4 bits (150), Expect = 9e-10
Identities = 38/171 (22%), Positives = 83/171 (48%), Gaps = 18/171 (10%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK-KIAEKEVR 280
++R+ ++++ RE ++E R+R+ E++ RE E++R R+ +R +K++TD+++ K ++E +
Sbjct: 46 RDRQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERK 105
Query: 281 IKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSG 340
+ + E+ + E+ K+ E D R E + +E
Sbjct: 106 RETDRNRERNRKGGRERDKQTERERD-----------------RERERQRQRERERQRQR 148
Query: 341 SDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKG 391
K D ER + E E ++ R+ + + RR + +++WG+G
Sbjct: 149 ERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEKRREDKKRKWGEG 199
Score = 49.7 bits (117), Expect = 6e-06
Identities = 28/84 (33%), Positives = 50/84 (59%), Gaps = 3/84 (3%)
Query: 222 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 281
+ R + +R R+ +RE +R+RE E++R RE ++ RE +R ++E K+++ E++
Sbjct: 120 RERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKER 179
Query: 282 KLLKKPEKGEEPTTEKPKERGEEI 305
K KK EK E +K ++ GE I
Sbjct: 180 KEKKKEEKRRE---DKKRKWGEGI 200
Score = 30.8 bits (68), Expect = 2.8
Identities = 39/201 (19%), Positives = 86/201 (42%), Gaps = 20/201 (9%)
Query: 285 KKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKE 344
++ ++G+E E+ ++R E T ++E+ + R + E ++T +
Sbjct: 9 RETDRGKETERERDRQRERENQT---EREN-------RHRQRDRHRERDRQTDREKERER 58
Query: 345 HRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSED-----EQRWGKGPGQDRGKK 399
++ +R +++E E +R + R + E +R + R D E++ ++R +K
Sbjct: 59 QKERDRQRQRERETER-ETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRK 117
Query: 400 GSQDSGAPGEA---MERLGRAQRCDDSPAPR-KERLANKDRPALQLYDPGARFRARECGG 455
G ++ E ER + QR + R ++R +++R + + R +E
Sbjct: 118 GGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKK 177
Query: 456 NRRICKAEGSGTGPEKREEAE 476
R+ K E +KR+ E
Sbjct: 178 ERKEKKKEEKRREDKKRKWGE 198
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 62.4 bits (150), Expect = 9e-10
Identities = 53/205 (25%), Positives = 98/205 (47%), Gaps = 21/205 (10%)
Query: 196 ETLLGEMEAKTRELIARRTTPLLEYIKNRK-LEKQRIRE------EKREERRRRELEKKR 248
E L E E R+L+A R + + + R+ LE+Q+ RE ++RE+RRR + EK+R
Sbjct: 378 EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRR 437
Query: 249 LREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTG 308
L E E+RR+ EEER + +E ++ + ++ +R +L ++ E + +E+ ++
Sbjct: 438 LEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECR 497
Query: 309 GGKQESCAPGAVVKARPMEGSLEEPQ------ETSHSGSDKEHRDVERSQEQESEAQRYH 362
+ E +A ++ L++ Q + H +H +QE +H
Sbjct: 498 WREMEEHR-----QAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFH 552
Query: 363 VDDGRRHRAHHEPERLSRRSEDEQR 387
+ +AH+EP +R ED R
Sbjct: 553 APE---PKAHYEPADRAREVEDRFR 574
Score = 52.8 bits (125), Expect = 7e-07
Identities = 62/257 (24%), Positives = 108/257 (42%), Gaps = 53/257 (20%)
Query: 201 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREE 260
+ E K R RR L E + E +R +R++R ++ E++R EE++RR RE
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 261 ERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAV 320
R ++E +++++ E++ R++ L++ K EE + R EE
Sbjct: 420 RR--QQEREQRRREQEEKRRLEELERRRKEEE-----ERRRAEE---------------- 456
Query: 321 VKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVD-DGRRHRAHHEPERLS 379
+ +E QE ++E R +E Q+Q + Q ++ R H + ERL
Sbjct: 457 -----EKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQ 511
Query: 380 RRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPAL 439
R+ + EQ + D + Q S P P P++ER +P+
Sbjct: 512 RQLQQEQAYLLSLQHDHRRPHPQHSQQP----------------PPPQQER----SKPSF 551
Query: 440 QLYDPGARF----RARE 452
+P A + RARE
Sbjct: 552 HAPEPKAHYEPADRARE 568
Score = 39.7 bits (91), Expect = 0.006
Identities = 46/225 (20%), Positives = 90/225 (40%), Gaps = 30/225 (13%)
Query: 186 VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELE 245
+EE++ E E + RE +R LE + + E++R EEKR R +E
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468
Query: 246 KKRLREEEKR------------------RRREEERCKKKETDKQKKIAEKEVRIKLLKKP 287
+++L EE++ R RE E ++ E Q+++ +++ + L+
Sbjct: 469 RRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAER-LQRQLQQEQAYLLSLQHD 527
Query: 288 EKGEEPT-TEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP---QETSHSGSDK 343
+ P +++P +E K AP P + + E ++T+HS +
Sbjct: 528 HRRPHPQHSQQPPPPQQE----RSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEA 583
Query: 344 EHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRW 388
+ + R E ++ +G H L R +E + +W
Sbjct: 584 QSKQTGRVLEPPVPSRSESFSNGNSESVH---PALQRPAEPQVQW 625
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 61.2 bits (147), Expect = 2e-09
Identities = 60/274 (21%), Positives = 127/274 (46%), Gaps = 13/274 (4%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
++K+R+++ K I + E + E E+E+ E ++ E E K R L
Sbjct: 320 EEKIREQEEK---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWE-- 374
Query: 218 LEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEK 277
+ K R+LE++ +EK E+ + E++++RE+EKR+ +E + +++E ++++ +
Sbjct: 375 -KEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 433
Query: 278 EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETS 337
E K+ ++ EK E + +E+ +E + ++E + R E E QE
Sbjct: 434 EQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEI-WRQKEKMHE--QEKI 490
Query: 338 HSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRG 397
+K R E+ +QE + + R+ E E R E++ R + Q++
Sbjct: 491 RKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQE 550
Query: 398 KKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERL 431
+K G E M+ + +R ++ ++E++
Sbjct: 551 EK----MGEQEEKMQEQEKMRRQEEKIREQEEKI 580
Score = 53.9 bits (128), Expect = 3e-07
Identities = 47/216 (21%), Positives = 100/216 (46%), Gaps = 10/216 (4%)
Query: 181 LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR 240
LE E+EK E E + + +E + + + + ++++IRE++++ R
Sbjct: 382 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWR 441
Query: 241 RREL--EKKRLREEEKR------RRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEE 292
+ E E++++REEEKR R+EE+ +++E +QK+ ++ +I+ ++ +E
Sbjct: 442 QEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQE 501
Query: 293 PTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQ 352
+E+ E + +QE K R E + E +E +K E+ Q
Sbjct: 502 EKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQ 561
Query: 353 EQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRW 388
EQE ++ + + + E++ R ++E+ W
Sbjct: 562 EQEKMRRQEEKIREQEEKIREQKEKI--REQEEKIW 595
Score = 51.6 bits (122), Expect = 2e-06
Identities = 61/247 (24%), Positives = 120/247 (48%), Gaps = 24/247 (9%)
Query: 158 KKKLRKKDAKTGSIE-DDPEYKKFLET--YCVEEEKTSANPETLLGEMEAKTRELIARRT 214
++KL+ +++ I+ + E K+ LE + +++ A + L E+++ + +L A+
Sbjct: 227 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 286
Query: 215 TPLLEYIKNRKLEKQRIREEKR----------EERRRRELEKKRLREEEKRRRREEERCK 264
L N++ E++ R+E++ +E + RE E+K +RE+E++ RR+EE
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK-IREQEEKMRRQEEMMW 345
Query: 265 KKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKAR 324
+KE +K ++E+ + +K + EE EK +E+ E++ +QE + R
Sbjct: 346 EKE---EKMRRQEEMMWEKEEKMRRLEEMMWEK-EEKIRELEEKMHEQEKIREQE--EKR 399
Query: 325 PMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERL---SRR 381
E + E QE K R E+ +EQE + + R+ HE E++ +R
Sbjct: 400 QEEEKIRE-QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKR 458
Query: 382 SEDEQRW 388
E E+ W
Sbjct: 459 QEQEEMW 465
Score = 50.8 bits (120), Expect = 3e-06
Identities = 56/208 (26%), Positives = 92/208 (44%), Gaps = 26/208 (12%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIAR-RTTPLLEYIKNRKLEKQRIREEKREERRRRELE 245
E E+ E + E E K RE + R + + K K+ +Q ++EE+ RR LE
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR-LE 369
Query: 246 KKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEI 305
+ +EEK R EE + +Q+KI E+E EK +E + +E+ +E
Sbjct: 370 EMMWEKEEKIRELEE------KMHEQEKIREQE---------EKRQEEEKIREQEKRQEQ 414
Query: 306 DTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQE-----SEAQR 360
+ +QE K R E + +E H ++ R+ E+ QEQE E R
Sbjct: 415 EAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH--EQEKIREEEKRQEQEEMWRQEEKIR 472
Query: 361 YHVDDGRRHRAHHEPERLSRRSEDEQRW 388
+ R+ HE E++ R ++E+ W
Sbjct: 473 EQEEIWRQKEKMHEQEKI--RKQEEKVW 498
Score = 50.4 bits (119), Expect = 3e-06
Identities = 63/249 (25%), Positives = 109/249 (43%), Gaps = 44/249 (17%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
++K+R+++ K E+ ++ + EEEK E E + + +E I R+ +
Sbjct: 429 EEKIREQEKKMWRQEEKIHEQEKIR----EEEKRQEQEEMWRQEEKIREQEEIWRQKEKM 484
Query: 218 LEYIKNRKLEKQRIREEKR---EERRRRELEKKRLREEEKRRRREE-------------- 260
E K RK E++ R+E++ +E + RE E+K R+EEK R +EE
Sbjct: 485 HEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEE 544
Query: 261 -----------ERCKKKETDK----QKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEI 305
+ K +E +K ++KI E+E +I+ K+ + +E EK E+ E+I
Sbjct: 545 MMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQE---EKIWEQEEKI 601
Query: 306 DTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDD 365
+QE K E + E +E +K R E+ EQE R +
Sbjct: 602 ----REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL-RQQEEK 656
Query: 366 GRRHRAHHE 374
+ H+ H E
Sbjct: 657 MQEHQEHLE 665
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 60.5 bits (145), Expect = 3e-09
Identities = 59/276 (21%), Positives = 126/276 (45%), Gaps = 20/276 (7%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTR---------- 207
++K+R+++ K I + E + E E+E+ E ++ E E K R
Sbjct: 320 EEKIREQEEK---IREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 376
Query: 208 ELIARRTTPLLEYI-KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKK 266
E + R+ + E K R+LE++ +EK E+ + E++++RE+EKR+ +E + +++
Sbjct: 377 EKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQE 436
Query: 267 ETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPM 326
E ++++ +E K+ ++ EK E + +E+ +E + ++E + +
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQ-- 494
Query: 327 EGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRS---- 382
+ + E +E +K R E+ +EQE + + R+ E E + R
Sbjct: 495 KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMH 554
Query: 383 EDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQ 418
E E+ W + Q++ K + E E++ R +
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQE 590
Score = 58.9 bits (141), Expect = 1e-08
Identities = 54/211 (25%), Positives = 104/211 (49%), Gaps = 17/211 (8%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIAR-RTTPLLEYIKNRKLEKQRIREEKREERRRRELE 245
E E+ E + E E K RE + R + + K K+ +Q ++EE+ RR+ E
Sbjct: 311 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQ-E 369
Query: 246 KKRLREEEKRRRREEERCKKKE--TDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGE 303
+ +EEK RR+EE +K+E + ++K+ E+E K+ ++ EK +E + +E+ +
Sbjct: 370 EMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQE---KIREQEEKRQEEEKIREQEKRQ 426
Query: 304 EIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQES---EAQR 360
E + +QE K R E + +E H ++ R+ E+ QEQE + ++
Sbjct: 427 EQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH--EQEKIREEEKRQEQEEMWRQEEK 484
Query: 361 YHVDD---GRRHRAHHEPERLSRRSEDEQRW 388
H + ++ + H + E++ R ++E+ W
Sbjct: 485 IHEQEEIWRQKEKMHEQEEKI--RKQEEKVW 513
Score = 54.7 bits (130), Expect = 2e-07
Identities = 53/236 (22%), Positives = 108/236 (45%), Gaps = 9/236 (3%)
Query: 158 KKKLRKKDAKTGSIED----DPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARR 213
++K+R+++ K E+ E + E EEEK + E + + + R+
Sbjct: 516 EEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQ 575
Query: 214 TTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKET--DKQ 271
+ E + ++++IRE+ E +R+E E+K ++EEK R +EE+ +++E +++
Sbjct: 576 EEKIREQEEKVWRQEEKIREQ---EEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQE 632
Query: 272 KKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLE 331
+KI E+E + ++ +E + +E+ +E + +QE K R E +
Sbjct: 633 EKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIR 692
Query: 332 EPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 387
E +E +K E+ EQE + Q R+ E E R+ E++ +
Sbjct: 693 EQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Score = 52.8 bits (125), Expect = 7e-07
Identities = 59/266 (22%), Positives = 119/266 (44%), Gaps = 28/266 (10%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
++K+R+++ K E+ ++ + EEEK E E + +E I R+ +
Sbjct: 443 EEKIREQEKKMWRQEEKIHEQEKIR----EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKM 498
Query: 218 LEYIKN---------RKLEKQRIREEK-REERRRRELEKKRLREEEKRRRRE-------- 259
E + R+ EK R +EEK RE+ + +++++RE+E+ R E
Sbjct: 499 HEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEK 558
Query: 260 --EERCKKKETDK----QKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQE 313
EE ++++ DK ++KI E+E ++ ++ + +E ++ +E+ + + +QE
Sbjct: 559 IWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQE 618
Query: 314 SCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHH 373
K R E + E +E + +K E+ EQE + Q R+
Sbjct: 619 EKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIR 678
Query: 374 EPERLSRRSEDEQRWGKGPGQDRGKK 399
E E+ R E++ R + Q++ +K
Sbjct: 679 EQEKKIREQEEKIREQEEMMQEQEEK 704
Score = 49.7 bits (117), Expect = 6e-06
Identities = 58/257 (22%), Positives = 121/257 (47%), Gaps = 30/257 (11%)
Query: 158 KKKLRKKDAKTGSIE-DDPEYKKFLET--YCVEEEKTSANPETLLGEMEAKTRELIARRT 214
++KL+ +++ I+ + E K+ LE + +++ A + L E+++ + +L A+
Sbjct: 227 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 286
Query: 215 TPLLEYIKNRKLEKQRIREEKR----------EERRRRELEKKRLREEEKRRRREEERCK 264
L N++ E++ R+E++ +E + RE E+K +RE+E++ RR+EE
Sbjct: 287 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK-IREQEEKMRRQEEMMW 345
Query: 265 KKET----------DKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQES 314
+KE +K++K+ +E + ++ + +E + +E+ E++ +QE
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 405
Query: 315 CAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHE 374
+ R E + E QE K R E+ +EQE + + R+ HE
Sbjct: 406 IREQE--EKRQEEEKIRE-QEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHE 462
Query: 375 PERL---SRRSEDEQRW 388
E++ +R E E+ W
Sbjct: 463 QEKIREEEKRQEQEEMW 479
Score = 43.1 bits (100), Expect = 5e-04
Identities = 35/145 (24%), Positives = 74/145 (51%), Gaps = 16/145 (11%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKT----------R 207
++K+R+++ K I++ E + E E+E+ + E +GE E K
Sbjct: 611 EEKIREQEEK---IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE 667
Query: 208 ELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKE 267
E + R+ + E K + ++++IRE+ E +E E+K +EEK +EE+ +++E
Sbjct: 668 ETMWRQEEKIREQEKKIREQEEKIREQ---EEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 724
Query: 268 TDKQKKIAEKEVRIKLLKKPEKGEE 292
++++ E ++L ++ EK +E
Sbjct: 725 KMRRQEEKMWEQEVRLRQQEEKMQE 749
Score = 40.8 bits (94), Expect = 0.003
Identities = 43/181 (23%), Positives = 85/181 (46%), Gaps = 13/181 (7%)
Query: 158 KKKLRKKDAKTG----SIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARR 213
++K+R+++ K I + E ++ E ++E+ E + E E K RE +
Sbjct: 576 EEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKI 635
Query: 214 TTPLLEYIKNRKLEKQRIREEK--REERRRRELEKKRLREEEKRRRREEERCKKKETDKQ 271
E + + EK +EEK +E + +E E+ R+EEK R +E KK +++
Sbjct: 636 REQ--EEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQE-----KKIREQE 688
Query: 272 KKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLE 331
+KI E+E ++ ++ +E + +E+ +E + +QE V+ R E ++
Sbjct: 689 EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748
Query: 332 E 332
E
Sbjct: 749 E 749
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 60.5 bits (145), Expect = 3e-09
Identities = 61/245 (24%), Positives = 108/245 (44%), Gaps = 28/245 (11%)
Query: 187 EEEKTSANPETLLGEMEAK---TRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRE 243
+EE+ + GEME +EL + E K R E+Q +E ++ ++ R
Sbjct: 671 DEEREKGEKDKGRGEMERPGEGEKELAEK------EEWKKRDGEEQEQKEREQGHQKERN 724
Query: 244 LEKKRLREEEKRRRREEERCKKKETDKQ---KKIAEKEVRIKLLKKPEKGEEPTTEKP-- 298
E + EEE EEE +++E +K+ K+ E E ++ ++ E+GE E+
Sbjct: 725 QEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGE-EVEGEREKEEGERKKEERAGK 783
Query: 299 KERGEEI-DTGGGKQESCA-------PGAVVKARPME---GSLEEPQETSHSGSDKEHRD 347
+E+GEE D G G++E G V+ +E G EE +E ++ +
Sbjct: 784 EEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843
Query: 348 VERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAP 407
E + +E E + ++G E E E+E+ G+G G++ G+ ++
Sbjct: 844 EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE--GEGEGEEEGEGEGEEEEGE 901
Query: 408 GEAME 412
GE E
Sbjct: 902 GEGEE 906
Score = 54.3 bits (129), Expect = 2e-07
Identities = 49/204 (24%), Positives = 88/204 (43%), Gaps = 15/204 (7%)
Query: 219 EYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 278
E+ ++ + EK + + E R E EK+ +EE ++R EE+ +K+ +K +E
Sbjct: 667 EHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQE 726
Query: 279 VRIKLLKKPEKGEEPTTEKPKERG----EEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 334
+ E GEE E +E G EE G GK+E + EG ++ +
Sbjct: 727 ME-------EGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEE 779
Query: 335 ETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 394
+E D +E+E+E + ++G E R E+E+ +G G+
Sbjct: 780 RAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE---EGEGE 836
Query: 395 DRGKKGSQDSGAPGEAMERLGRAQ 418
+ +G ++ G GE E G+ +
Sbjct: 837 EEEGEGEEEEG-EGEEEEGEGKGE 859
Score = 49.3 bits (116), Expect = 8e-06
Identities = 56/263 (21%), Positives = 99/263 (37%), Gaps = 20/263 (7%)
Query: 227 EKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKK 286
E + + E+ +E R+ E++ +EE+ ++ +++ET+ + + E+ ++ +
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
Query: 287 PE------------KGEEPTTEKPKERGE-EIDTGGGKQESCAPGAVVKARPMEGSLEEP 333
E +GEE E +E GE E + G GK E + EG E
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE 879
Query: 334 QETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAH--HEPERLSRRSEDEQRWGKG 391
+E ++E +E E E + +G E E E E+ G+G
Sbjct: 880 EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEG 939
Query: 392 PGQDRGKKGSQDSGA-PGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRA 450
G+D +G ++ G GE E G + + E ++ G
Sbjct: 940 EGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE----GEGEEEEG 995
Query: 451 RECGGNRRICKAEGSGTGPEKRE 473
E G + EG G G E+ E
Sbjct: 996 EEEGEEEGEGEEEGEGEGEEEEE 1018
Score = 37.0 bits (84), Expect = 0.039
Identities = 40/180 (22%), Positives = 72/180 (40%), Gaps = 5/180 (2%)
Query: 234 EKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEP 293
E+ E E E + EEE+ + EE ++ E + +++ E E + E+ E
Sbjct: 896 EEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEW 955
Query: 294 TTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHS-GSDKEHRDVERSQ 352
E+ + GE + G G+ E + EG EE +E G +E + E +
Sbjct: 956 EGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEE 1015
Query: 353 EQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAME 412
E+E E + + E E E E+R +G G++ + ++ G+ E
Sbjct: 1016 EEEGEVE----GEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071
Score = 33.1 bits (74), Expect = 0.57
Identities = 56/254 (22%), Positives = 89/254 (35%), Gaps = 29/254 (11%)
Query: 245 EKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEE 304
E+K E+ K EE+ + E + + KE L E + K K GE
Sbjct: 588 EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEA 647
Query: 305 IDTGGGKQE-SCAPGAVVKARPMEGSLEEPQETSHSGS-DKEHRDVERSQEQESEAQRYH 362
D G+ + +C G+ G+ E G DK ++ER E E E
Sbjct: 648 EDGPEGRGDGTCEEGS-------SGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
Query: 363 VDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLG------- 415
R + ER ++ + + G++ +G ++ G E E+ G
Sbjct: 701 EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE 760
Query: 416 ----RAQRCDDSPAPRKERLANKDRPALQLYDPG--------ARFRARECGGNRRICKA- 462
+R + +KE A K+ + D G R +E GG +
Sbjct: 761 GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVE 820
Query: 463 EGSGTGPEKREEAE 476
EG G E+ EE E
Sbjct: 821 EGKGEREEEEEEGE 834
Score = 32.7 bits (73), Expect = 0.74
Identities = 35/158 (22%), Positives = 59/158 (37%), Gaps = 7/158 (4%)
Query: 233 EEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEE 292
EE+ E E E + EEE EE + +E + + + E+E E+GEE
Sbjct: 949 EEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE-------EEGEE 1001
Query: 293 PTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQ 352
+ + GE + G+ E G + E EE E + E R +
Sbjct: 1002 EGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREE 1061
Query: 353 EQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGK 390
E+E E + + R E + + + ++GK
Sbjct: 1062 EEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGK 1099
Score = 29.6 bits (65), Expect = 6.3
Identities = 24/97 (24%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 221 IKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKET---DKQKKIAEK 277
++ + E + EE EE RE E + R EEE K +ET + +++ E+
Sbjct: 1025 VEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
Query: 278 EVRIKLLKKPEK-GEEPTTEKPKERGEEIDTGGGKQE 313
++ +K K G+ T +K + G GK++
Sbjct: 1085 YKKVSKIKGSVKYGKHKTYQKKSVTNTQ---GNGKEQ 1118
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 60.1 bits (144), Expect = 4e-09
Identities = 45/230 (19%), Positives = 110/230 (47%), Gaps = 16/230 (6%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK 246
E+E+ E +GE E + R+ + + +++KQ + +K+EE+ R++ E+
Sbjct: 210 EQEEQMQKQEEQMGEQEEQMRKQEEQMGE------QEEQVQKQEEQVQKQEEQMRKQEEQ 263
Query: 247 KRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEID 306
R +EE+ R + E+ +K++T+++++ E+E +++ ++ + +E + +E+ E +
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE 323
Query: 307 TGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDG 366
GKQE + + + E +E ++ E+ Q+QE + ++
Sbjct: 324 EQMGKQEE-------QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR 376
Query: 367 RRHRAHHEPERLSRRSED---EQRWGKGPGQDRGKKGSQDSGAPGEAMER 413
++ + E R+ E+ EQ+ G +++ ++ + G E M +
Sbjct: 377 KQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426
Score = 46.6 bits (109), Expect = 5e-05
Identities = 40/230 (17%), Positives = 105/230 (45%), Gaps = 22/230 (9%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK 246
E+E E +GE E + ++ + ++ +Q + K+EE+ + E+
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQK-------------QEEQMGEQEEQMRKQEEQMGEQEEQ 242
Query: 247 KRLREEEKRRRREEERCKKKE-TDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEI 305
+ +EE+ +++ E+ R ++++ ++++++ E+E ++ K+ + EE T E+ ++ E+
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 306 DTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDD 365
+ ++E + R E + E +E ++ E+ EQ+ + +
Sbjct: 303 EQMREQEE--------QMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM 354
Query: 366 GRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLG 415
G + + E R+ E++ R + + + ++ + GE E++G
Sbjct: 355 GEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404
Score = 42.7 bits (99), Expect = 7e-04
Identities = 47/243 (19%), Positives = 107/243 (44%), Gaps = 27/243 (11%)
Query: 206 TRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK------KRLREEEKRRRRE 259
T E + + L E ++ + EK I+ +E +R+ E +K ++RE+E + R +
Sbjct: 5 TNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQ 64
Query: 260 EERCKKKE---TDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCA 316
E + +++E +++ ++ E+E +++ + + +E + + + E + +QE
Sbjct: 65 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 124
Query: 317 PGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPE 376
+ R EG + E + G +E R QE + Q V E E
Sbjct: 125 REQEGQVREQEGQVREQE-----GQVREQEGQVREQEGQVREQEGQV---------REQE 170
Query: 377 RLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLG----RAQRCDDSPAPRKERLA 432
R E + R +G +++ + + G GE E++G + Q+ ++ ++E++
Sbjct: 171 GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230
Query: 433 NKD 435
++
Sbjct: 231 KQE 233
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/226 (17%), Positives = 100/226 (44%), Gaps = 9/226 (3%)
Query: 187 EEEKTSANPETLLGEMEAKTREL---IARRTTPLLEYIKNRKLEKQRIREEK---REERR 240
E+E E + E E + RE + + + E + ++ ++RE++ RE+
Sbjct: 70 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 241 RRELEKKRLREEEKRRRREEERCKKKE---TDKQKKIAEKEVRIKLLKKPEKGEEPTTEK 297
+ ++ ++RE+E + R +E + +++E +++ ++ E+E +++ + + +E +
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189
Query: 298 PKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESE 357
+ + E + G+QE + + E + E +E ++ E+ Q+QE +
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249
Query: 358 AQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQD 403
Q+ ++ E E R E++ K + + G Q+
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQE 295
Score = 41.2 bits (95), Expect = 0.002
Identities = 36/165 (21%), Positives = 85/165 (51%), Gaps = 11/165 (6%)
Query: 154 QKIAKKKLRKKDAKTGSIEDD----PEYKKFLETYCVEEEKTSANPETLLGEMEAKTREL 209
Q + +K+ +++ +TG E+ E + E E+E+ E +G+ E + E
Sbjct: 277 QMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ 336
Query: 210 IARRTTPLLEYIKNRK-LEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKET 268
+ + K + + +Q + +K+EE+ R++ E+ R +EE+ R++ E+ R ++++
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQM 396
Query: 269 DKQK-KIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQ 312
+QK ++ E++ +++ E+ E+ +K + R +E G K+
Sbjct: 397 GEQKEQMGEQKEQMR-----EQEEQMGEQKEQMRKQEEHMGEQKE 436
Score = 38.5 bits (88), Expect = 0.013
Identities = 54/319 (16%), Positives = 132/319 (41%), Gaps = 32/319 (10%)
Query: 187 EEEKTSANPETLLGEMEAKTREL---IARRTTPLLEYIKNRKLEKQRIREEK---REERR 240
E+E E + E E + RE + + + E + ++ ++RE++ RE+
Sbjct: 105 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 164
Query: 241 RRELEKKRLREEEKRRRREEERCKKKET---DKQKKIAEKEVRI----KLLKKPEK---G 290
+ ++ ++RE+E + R +E + +++E +++ ++ E+E ++ + ++K E+
Sbjct: 165 QVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE 224
Query: 291 EEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVER 350
+E K +E+ E + KQE + R E + E +E ++ + E+
Sbjct: 225 QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ 284
Query: 351 SQEQ----ESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ------------ 394
++++ E E Q ++ R + E+ + E E++ GK Q
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344
Query: 395 DRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECG 454
++ K + G E M++ R + ++E K ++ + + + G
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404
Query: 455 GNRRICKAEGSGTGPEKRE 473
+ + + G +K +
Sbjct: 405 EQKEQMREQEEQMGEQKEQ 423
Score = 37.7 bits (86), Expect = 0.023
Identities = 40/216 (18%), Positives = 94/216 (43%), Gaps = 15/216 (6%)
Query: 187 EEEKTSANPETLLGEMEAKTREL---IARRTTPLLEYIKNRKLEKQRIREEK---REERR 240
E+E E + E E + RE + + + E + ++ ++RE++ RE+
Sbjct: 98 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 157
Query: 241 RRELEKKRLREEEKRRRREEERCKKKE---TDKQKKIAEKEVRIKLLKKPEKGEEPTTEK 297
+ ++ ++RE+E + R +E + +++E +++ ++ E+E ++ ++ +E +K
Sbjct: 158 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQK 217
Query: 298 PKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQE-- 355
+E+ E + KQE + + E +++ +E ++ E+ +EQE
Sbjct: 218 QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQ 277
Query: 356 ----SEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 387
E G + E E R E++ R
Sbjct: 278 MLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR 313
Score = 32.7 bits (73), Expect = 0.74
Identities = 49/213 (23%), Positives = 90/213 (42%), Gaps = 10/213 (4%)
Query: 230 RIREEKREERRRRELEKKRLREEEKR--RRREEERCKKKETDKQKKIAEKEVRIKLLKKP 287
RI E+ +E+ E+ +L E EK + +E +K ETDK E +VR + +
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62
Query: 288 EKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSL--EEPQETSHSGSDKEH 345
E+ + ++ + R +E +QE + R EG + +E Q G +E
Sbjct: 63 EQEGQVREQEGQVREQEGQVR--EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 120
Query: 346 RDVERSQE---QESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQ 402
R QE +E E Q + R + E+ + E E + + GQ R ++G Q
Sbjct: 121 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-Q 179
Query: 403 DSGAPGEAMERLGRAQRCDDSPAPRKERLANKD 435
G+ E+ G+ + ++E++ ++
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQE 212
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 60.1 bits (144), Expect = 4e-09
Identities = 61/253 (24%), Positives = 116/253 (45%), Gaps = 16/253 (6%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPL 217
++K+R+++ E E + LE E+EK E + E K RE R+
Sbjct: 423 EEKMRRQEEMMWEKE---EKIRELEEKMHEQEKIREQEEKR--QEEEKIREQEKRQEQEA 477
Query: 218 LEYIKNRKLEKQRIREEKREERRRRELEK----KRLREEEKRRR-----REEERCKKKET 268
+ + K+ +Q + ++EE+ R+ EK +++REEEKR+ R+EE+ +++E
Sbjct: 478 KMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEE 537
Query: 269 --DKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPM 326
+++KI E+E +I+ ++ +E +E+ E + +QE K R
Sbjct: 538 IWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQ 597
Query: 327 EGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQ 386
E + E +E + +K E+ EQE + Q R+ E E+ R E++
Sbjct: 598 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKI 657
Query: 387 RWGKGPGQDRGKK 399
R + Q++ +K
Sbjct: 658 REQEEMMQEQEEK 670
Score = 57.8 bits (138), Expect = 2e-08
Identities = 60/237 (25%), Positives = 108/237 (45%), Gaps = 12/237 (5%)
Query: 158 KKKLRKKDAKTGSIEDD---PEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRT 214
++K+R+++ K E+ E K + EEEK E E + + +E I R+
Sbjct: 483 EEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQK 542
Query: 215 TPLLEYI-KNRKLEKQRIREEKR---EERRRRELEKKRLREEEKRRRREEERCKKKETDK 270
+ E K RK E++ R+E++ +E + RE E+K R+EEK R +EE K ++
Sbjct: 543 EKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEE-----KIREQ 597
Query: 271 QKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSL 330
++KI E+E + ++ +E + +E+ +E + +QE K R E +
Sbjct: 598 EEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKI 657
Query: 331 EEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 387
E +E +K E+ EQE + Q R+ E E R+ E++ +
Sbjct: 658 REQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 714
Score = 57.4 bits (137), Expect = 3e-08
Identities = 62/257 (24%), Positives = 114/257 (44%), Gaps = 32/257 (12%)
Query: 158 KKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTREL---IARRT 214
++K+R+++ K E E +K E +E E + E E K RE + R+
Sbjct: 450 QEKIREQEEKRQEEEKIREQEKRQE-----QEAKMWRQEEKIREQEEKIREQEEKMWRQE 504
Query: 215 TPLLEYIKNRKLEKQRIREEK-REERRRRELE-----KKRLREEEKRRRREEERCKKKET 268
+ E K R+ EK++ +EE R+E + RE E K+++ E+E++ R++EE+ ++E
Sbjct: 505 EKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEE 564
Query: 269 D-----------------KQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK 311
+++KI E+E +I+ ++ + +E T++ +E+ E + +
Sbjct: 565 KMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 624
Query: 312 QESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRA 371
QE K R E + E ++ +K E QEQE + +
Sbjct: 625 QEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEK 684
Query: 372 HHEPERLSRRSEDEQRW 388
E E RR E E+ W
Sbjct: 685 MQEQEEKMRRQE-EKMW 700
Score = 54.3 bits (129), Expect = 2e-07
Identities = 52/183 (28%), Positives = 90/183 (49%), Gaps = 30/183 (16%)
Query: 227 EKQRIREEKREERRRREL-----EKKRLREE-----EKRRRREEERCKKKETDKQKKIAE 276
++++IRE++ + RR+ E+ EK R +EE E++ RR+EE +KE +K +++ E
Sbjct: 387 QEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE-EKIRELEE 445
Query: 277 K-EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQE 335
K + K+ ++ EK +E + +E+ +E + +QE K R E + E +E
Sbjct: 446 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-------KIREQEEKIREQEE 498
Query: 336 TSHSGSDKEH-----RDVERSQEQE-----SEAQRYHVDDGRRHRAHHEPERLSRRSEDE 385
+K H R+ E+ QEQE E R + R+ HE E R+ E E
Sbjct: 499 KMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQE-E 557
Query: 386 QRW 388
+ W
Sbjct: 558 KMW 560
Score = 52.4 bits (124), Expect = 9e-07
Identities = 61/247 (24%), Positives = 120/247 (48%), Gaps = 24/247 (9%)
Query: 158 KKKLRKKDAKTGSIE-DDPEYKKFLET--YCVEEEKTSANPETLLGEMEAKTRELIARRT 214
++KL+ +++ I+ + E K+ LE + +++ A + L E+++ + +L A+
Sbjct: 288 QEKLQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVE 347
Query: 215 TPLLEYIKNRKLEKQRIREEKR----------EERRRRELEKKRLREEEKRRRREEERCK 264
L N++ E++ R+E++ +E + RE E+K +RE+E++ RR+EE
Sbjct: 348 ENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEK-IREQEEKMRRQEEMMW 406
Query: 265 KKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKAR 324
+KE +K ++E+ + +K + EE EK +E+ E++ +QE + R
Sbjct: 407 EKE---EKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQEKIREQE--EKR 460
Query: 325 PMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERL---SRR 381
E + E QE K R E+ +EQE + + R+ HE E++ +R
Sbjct: 461 QEEEKIRE-QEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKR 519
Query: 382 SEDEQRW 388
E E+ W
Sbjct: 520 QEQEEMW 526
Score = 50.4 bits (119), Expect = 3e-06
Identities = 49/208 (23%), Positives = 95/208 (45%), Gaps = 9/208 (4%)
Query: 187 EEEKTSANPETLLGEMEAKTRELIAR-RTTPLLEYIKNRKLEKQRIREEKREERRRRELE 245
E E+ E + E E K RE + R + + K K+ +Q ++EE+ RR+ E
Sbjct: 372 EWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEE 431
Query: 246 -----KKRLRE-EEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPK 299
++++RE EEK +E+ R ++++ +++KI E+E R + K + EE E+ +
Sbjct: 432 MMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEE 491
Query: 300 ERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE--PQETSHSGSDKEHRDVERSQEQESE 357
+ E+ + ++E ++ EE QE ++ R E+ EQE +
Sbjct: 492 KIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEK 551
Query: 358 AQRYHVDDGRRHRAHHEPERLSRRSEDE 385
++ R+ H+ E R E++
Sbjct: 552 IRKQEEKMWRQEEKMHDQEEKIREQEEK 579
Score = 32.7 bits (73), Expect = 0.74
Identities = 32/128 (25%), Positives = 62/128 (48%), Gaps = 16/128 (12%)
Query: 154 QKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETL------LGEMEAKTR 207
+KI +++ + ++ + + E + + + E C +EEK E + + E E K R
Sbjct: 592 EKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIR 651
Query: 208 ELIARRTTPLLEYIKNRKLEKQRIREEK---REERRRRELEKKRLREE-----EKRRRRE 259
E + E + + EK +EEK +EE+ + + EK R +EE E R R++
Sbjct: 652 EQEEKIREQ--EEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQ 709
Query: 260 EERCKKKE 267
EE+ ++ +
Sbjct: 710 EEKMQEHQ 717
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 60.1 bits (144), Expect = 4e-09
Identities = 48/186 (25%), Positives = 90/186 (48%), Gaps = 21/186 (11%)
Query: 224 RKLEKQRIREEKREERRRRELEKKRLREEEKRRR--REEERCKKKETDKQKKIAEKEVRI 281
RK E +++R +K EE +RR LE+ +L+ EE+ R+ + ER ++ + +K+K+I +K +I
Sbjct: 547 RKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Query: 282 KLLKKPEKGEEPTTEKPKERG-----EEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 336
+ K E EK K++ EE++ ++E +AR + +E +E
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE--------EARRLRWLQQEEEER 658
Query: 337 SHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDR 396
H +++ +E+E E R + R + R R E E+R + Q+R
Sbjct: 659 RH------QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
Query: 397 GKKGSQ 402
++ Q
Sbjct: 713 REQERQ 718
Score = 53.1 bits (126), Expect = 5e-07
Identities = 56/253 (22%), Positives = 108/253 (42%), Gaps = 14/253 (5%)
Query: 186 VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKN------RKLEKQRIREEKREER 239
VE+E+ E E R+ + LE +K RK+ + R R E+ +E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
Query: 240 RRRELEKKRLREEEKRRRREEERCKKKETDKQ---KKIAEKEVRIKLLKKPEKGEEPTTE 296
+++++E+K + +EK + +EER +++ K+ KK+ E E R K ++ + E
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
Query: 297 KPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQES 356
+ + R +E+ ++E +A+ + E + ++E R+ ER +++
Sbjct: 655 EEERRHQELLQKKKEEEQERLRKAAEAKRL-AEQREQERREQERREQERREQERREQERR 713
Query: 357 EAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGR 416
E +R + RR E ERL E ++R Q + + E +RL
Sbjct: 714 EQERQLAEQERR----REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 769
Query: 417 AQRCDDSPAPRKE 429
Q ++ KE
Sbjct: 770 RQLQEEQEKKAKE 782
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/201 (20%), Positives = 95/201 (47%), Gaps = 17/201 (8%)
Query: 159 KKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLL 218
K+ +KK + + D + +K E EE+ + E+EA+ ++ R L
Sbjct: 592 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
Query: 219 EYIKNRKLEKQRIREEKREE--RRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAE 276
+ + + ++ ++++K EE R R+ E KRL E+ ++ RRE+ER +++ +++++ E
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
Query: 277 KEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 336
+ + + L + E+ E + + +E + Q+ ++ LEE ++
Sbjct: 712 RREQERQLAEQERRREQERLQAERELQEREKALRLQK----------EQLQRELEEKKK- 760
Query: 337 SHSGSDKEHRDVERSQEQESE 357
+++ R ER ++E E
Sbjct: 761 ----KEEQQRLAERQLQEEQE 777
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 28/226 (12%)
Query: 137 LDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLET----YCVEEEKTS 192
++ K + E A +++A++K +KK A E + K+ E + +EE+
Sbjct: 599 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 658
Query: 193 ANPETLLGEMEAKTRELI-ARRTTPLLEYIKNRKLEKQRIREEKREERRRR--------- 242
+ E L + E + L A L E + + E++R +E+RE+ RR
Sbjct: 659 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 718
Query: 243 --ELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 300
E E++R +E + R +ER K K++ E E + K ++ E E+ ++
Sbjct: 719 LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 778
Query: 301 RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHR 346
+ +E A GA KA + ++ P TS+ + + HR
Sbjct: 779 KAKE-----------AAGA-SKALNVTVDVQSPACTSYQMTPQGHR 812
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 60.1 bits (144), Expect = 4e-09
Identities = 48/186 (25%), Positives = 90/186 (48%), Gaps = 21/186 (11%)
Query: 224 RKLEKQRIREEKREERRRRELEKKRLREEEKRRR--REEERCKKKETDKQKKIAEKEVRI 281
RK E +++R +K EE +RR LE+ +L+ EE+ R+ + ER ++ + +K+K+I +K +I
Sbjct: 543 RKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 602
Query: 282 KLLKKPEKGEEPTTEKPKERG-----EEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 336
+ K E EK K++ EE++ ++E +AR + +E +E
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE--------EARRLRWLQQEEEER 654
Query: 337 SHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDR 396
H +++ +E+E E R + R + R R E E+R + Q+R
Sbjct: 655 RH------QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708
Query: 397 GKKGSQ 402
++ Q
Sbjct: 709 REQERQ 714
Score = 52.4 bits (124), Expect = 9e-07
Identities = 53/238 (22%), Positives = 103/238 (43%), Gaps = 14/238 (5%)
Query: 201 EMEAKTRELIARRTTPLLEYIKN------RKLEKQRIREEKREERRRRELEKKRLREEEK 254
E E R+ + LE +K RK+ + R R E+ +E +++++E+K + +EK
Sbjct: 546 EAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK 605
Query: 255 RRRREEERCKKKETDKQ---KKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK 311
+ +EER +++ K+ KK+ E E R K ++ + E+ + R +E+ +
Sbjct: 606 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE 665
Query: 312 QESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRA 371
+E +A+ + E + ++E R+ ER +++ E +R + RR
Sbjct: 666 EEQERLRKAAEAKRL-AEQREQERREQERREQERREQERREQERREQERQLAEQERR--- 721
Query: 372 HHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKE 429
E ERL E ++R Q + + E +RL Q ++ KE
Sbjct: 722 -REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
Score = 50.8 bits (120), Expect = 3e-06
Identities = 42/201 (20%), Positives = 95/201 (47%), Gaps = 17/201 (8%)
Query: 159 KKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLL 218
K+ +KK + + D + +K E EE+ + E+EA+ ++ R L
Sbjct: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647
Query: 219 EYIKNRKLEKQRIREEKREE--RRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAE 276
+ + + ++ ++++K EE R R+ E KRL E+ ++ RRE+ER +++ +++++ E
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
Query: 277 KEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 336
+ + + L + E+ E + + +E + Q+ ++ LEE ++
Sbjct: 708 RREQERQLAEQERRREQERLQAERELQEREKALRLQK----------EQLQRELEEKKK- 756
Query: 337 SHSGSDKEHRDVERSQEQESE 357
+++ R ER ++E E
Sbjct: 757 ----KEEQQRLAERQLQEEQE 773
Score = 43.9 bits (102), Expect = 3e-04
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 28/226 (12%)
Query: 137 LDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLET----YCVEEEKTS 192
++ K + E A +++A++K +KK A E + K+ E + +EE+
Sbjct: 595 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 654
Query: 193 ANPETLLGEMEAKTRELI-ARRTTPLLEYIKNRKLEKQRIREEKREERRRR--------- 242
+ E L + E + L A L E + + E++R +E+RE+ RR
Sbjct: 655 RHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQ 714
Query: 243 --ELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 300
E E++R +E + R +ER K K++ E E + K ++ E E+ ++
Sbjct: 715 LAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEK 774
Query: 301 RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHR 346
+ +E A GA KA + ++ P TS+ + + HR
Sbjct: 775 KAKE-----------AAGA-SKALNVTVDVQSPACTSYQMTPQGHR 808
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,230,757
Number of Sequences: 37866
Number of extensions: 1269622
Number of successful extensions: 28046
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 706
Number of HSP's successfully gapped in prelim test: 991
Number of HSP's that attempted gapping in prelim test: 8464
Number of HSP's gapped (non-prelim): 7746
length of query: 476
length of database: 18,247,518
effective HSP length: 106
effective length of query: 370
effective length of database: 14,233,722
effective search space: 5266477140
effective search space used: 5266477140
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.