Search of human proteins with 126723750

Search of human proteins with 126723750

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|126723750 dehydrogenase/reductase (SDR family) member 4 like
1 [Homo sapiens]
         (281 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|126723750 dehydrogenase/reductase (SDR family) member 4 like ...   554   e-158
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...   438   e-123
gi|126723191 dehydrogenase/reductase (SDR family) member 4 like ...   302   2e-82
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi...   258   3e-69
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap...   215   4e-56
gi|40254992 carbonic reductase 4 [Homo sapiens]                        96   4e-20
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]     95   8e-20
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              94   1e-19
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           92   5e-19
gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]     89   3e-18
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        70   2e-12
gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]                 69   5e-12
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    66   3e-11
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]      66   4e-11
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]       66   4e-11
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [...    64   1e-10
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         64   1e-10
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    63   3e-10
gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]        61   1e-09
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          61   1e-09
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi...    57   1e-08
gi|239756089 PREDICTED: similar to hCG1645561 [Homo sapiens]           57   2e-08
gi|239750620 PREDICTED: similar to hCG1645561 [Homo sapiens]           57   2e-08
gi|239744927 PREDICTED: similar to hCG1645561 [Homo sapiens]           57   2e-08
gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo...    57   2e-08
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     55   7e-08
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]    55   9e-08
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    54   2e-07
gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B...    53   3e-07
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa...    52   4e-07

>gi|126723750 dehydrogenase/reductase (SDR family) member 4 like 1
           [Homo sapiens]
          Length = 281

 Score =  554 bits (1427), Expect = e-158
 Identities = 281/281 (100%), Positives = 281/281 (100%)

Query: 1   MHKARLRGHCARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVV 60
           MHKARLRGHCARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVV
Sbjct: 1   MHKARLRGHCARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVV 60

Query: 61  VSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNS 120
           VSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNS
Sbjct: 61  VSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNS 120

Query: 121 KRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLP 180
           KRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLP
Sbjct: 121 KRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLP 180

Query: 181 GFSPYNVSKTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL 240
           GFSPYNVSKTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL
Sbjct: 181 GFSPYNVSKTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL 240

Query: 241 RIRRLGEPEDSLGIVSFLCSEDASYLTGETVMVGGGTPSRL 281
           RIRRLGEPEDSLGIVSFLCSEDASYLTGETVMVGGGTPSRL
Sbjct: 241 RIRRLGEPEDSLGIVSFLCSEDASYLTGETVMVGGGTPSRL 281


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score =  438 bits (1127), Expect = e-123
 Identities = 228/281 (81%), Positives = 247/281 (87%), Gaps = 3/281 (1%)

Query: 1   MHKARLRGHCARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVV 60
           MHKA L G CARA  SVR+ASSGMTRRDPL NKVALVTASTD IGFA+A+RLAQDGAHVV
Sbjct: 1   MHKAGLLGLCARAWNSVRMASSGMTRRDPLANKVALVTASTDGIGFAIARRLAQDGAHVV 60

Query: 61  VSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNS 120
           VS RKQQNVDQAVATLQGEGLS+TGTVCHVGK +D ERLVATA+KLHG IDIL   ++N+
Sbjct: 61  VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVATAVKLHGGIDIL---VSNA 117

Query: 121 KRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLP 180
               F+ +++   EE WD+ LDIN KA ALM KAVVPEMEKRGGGSV  ++S+AAF P P
Sbjct: 118 AVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSP 177

Query: 181 GFSPYNVSKTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL 240
           GFSPYNVSKTALLGL KTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL
Sbjct: 178 GFSPYNVSKTALLGLTKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETL 237

Query: 241 RIRRLGEPEDSLGIVSFLCSEDASYLTGETVMVGGGTPSRL 281
           RIRRLGEPED  GIVSFLCSEDASY+TGETV+VGGGTPSRL
Sbjct: 238 RIRRLGEPEDCAGIVSFLCSEDASYITGETVVVGGGTPSRL 278


>gi|126723191 dehydrogenase/reductase (SDR family) member 4 like 2
           [Homo sapiens]
          Length = 232

 Score =  302 bits (773), Expect = 2e-82
 Identities = 162/213 (76%), Positives = 178/213 (83%), Gaps = 3/213 (1%)

Query: 1   MHKARLRGHCARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVV 60
           M  ARL G CA A KSVR+ASS MTRRDPLTNKVALVTASTD IGFA+A+RLAQD AHVV
Sbjct: 1   MQMARLLGLCAWARKSVRMASSRMTRRDPLTNKVALVTASTDGIGFAIARRLAQDRAHVV 60

Query: 61  VSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNS 120
           VS RKQQNVDQAVATLQGEGLS+TGTVCHVGK +D ERLVA A+KLHG IDIL   ++N+
Sbjct: 61  VSSRKQQNVDQAVATLQGEGLSVTGTVCHVGKAEDRERLVAMAVKLHGGIDIL---VSNA 117

Query: 121 KRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLP 180
               F+ +L+   EE WD+ LDIN KA ALM KAVVPEMEKRGGGSV  ++S+AAF P P
Sbjct: 118 AVNPFFGSLMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVVIVSSIAAFSPSP 177

Query: 181 GFSPYNVSKTALLGLNKTLAIELAPRNIRVNCL 213
           GFSPYNVSKTALLGLN TLAIELAPRNIRVNCL
Sbjct: 178 GFSPYNVSKTALLGLNNTLAIELAPRNIRVNCL 210


>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
           sapiens]
          Length = 280

 Score =  258 bits (660), Expect = 3e-69
 Identities = 139/267 (52%), Positives = 192/267 (71%), Gaps = 8/267 (2%)

Query: 10  CARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNV 69
           CAR   SVR++S+G+ R+  L N+VA+VT ST  IGFA+A+RLA+DGAHVV+S RKQQNV
Sbjct: 16  CARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNV 73

Query: 70  DQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSI-TNSKRGLFWFT 128
           D+A+A LQGEGLS+ G VCHVGK +D E+LVA A++  G +D L  S   N   G    +
Sbjct: 74  DRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVG----S 129

Query: 129 LLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVS 188
            L T+E+ WD+ L +N K+ AL++  ++P ME R G  +  ++S+AA+ P+     YNVS
Sbjct: 130 TLGTSEQIWDKILSVNVKSPALLLSQLLPYMENRRGAVI-LVSSIAAYNPVVALGVYNVS 188

Query: 189 KTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEP 248
           KTALLGL +TLA+ELAP++IRVNC+ PG+IKT FS++   ++   ++ KE  +++R+GE 
Sbjct: 189 KTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVFHGNESLWKNFKEHHQLQRIGES 248

Query: 249 EDSLGIVSFLCSEDASYLTGETVMVGG 275
           ED  GIVSFLCS DASY+ GE + V G
Sbjct: 249 EDCAGIVSFLCSPDASYVNGENIAVAG 275


>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
           sapiens]
          Length = 300

 Score =  215 bits (547), Expect = 4e-56
 Identities = 117/218 (53%), Positives = 161/218 (73%), Gaps = 8/218 (3%)

Query: 10  CARAGKSVRLASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNV 69
           CAR   SVR++S+G+ R+  L N+VA+VT ST  IGFA+A+RLA+DGAHVV+S RKQQNV
Sbjct: 16  CARL--SVRMSSTGIDRKGVLANRVAVVTGSTSGIGFAIARRLARDGAHVVISSRKQQNV 73

Query: 70  DQAVATLQGEGLSMTGTVCHVGKMKDWERLVATAMKLHGVIDILSLSI-TNSKRGLFWFT 128
           D+A+A LQGEGLS+ G VCHVGK +D E+LVA A++  G +D L  S   N   G    +
Sbjct: 74  DRAMAKLQGEGLSVAGIVCHVGKAEDREQLVAKALEHCGGVDFLVCSAGVNPLVG----S 129

Query: 129 LLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVS 188
            L T+E+ WD+ L +N K+ AL++  ++P ME R  G+V  ++S+AA+ P+     YNVS
Sbjct: 130 TLGTSEQIWDKILSVNVKSPALLLSQLLPYMENR-RGAVILVSSIAAYNPVVALGVYNVS 188

Query: 189 KTALLGLNKTLAIELAPRNIRVNCLAPGLIKTSFSRML 226
           KTALLGL +TLA+ELAP++IRVNC+ PG+IKT FS+++
Sbjct: 189 KTALLGLTRTLALELAPKDIRVNCVVPGIIKTDFSKVV 226


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 95.9 bits (237), Expect = 4e-20
 Identities = 75/245 (30%), Positives = 119/245 (48%), Gaps = 14/245 (5%)

Query: 32  NKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVG 91
           +KV  V   +  IG AVAQ +A+ G  + V  R  +    A   L G+ L+ +   C V 
Sbjct: 2   DKVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDHLAFS---CDVA 58

Query: 92  KMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALALM 151
           K  D +       K  G ++ L  +   ++ GL    L++T  E     L  N     L 
Sbjct: 59  KEHDVQNTFEELEKHLGRVNFLVNAAGINRDGL----LVRTKTEDMVSQLHTNLLGSMLT 114

Query: 152 IKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNIRVN 211
            KA +  M ++ GGS+  + S+   +   G S Y+ SK  L+G ++ LA E+A + IRVN
Sbjct: 115 CKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVN 174

Query: 212 CLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDASYLTGETV 271
            +APG + T  ++ L     KEE +K+ + + R GE  +    V FL   ++ Y+TG  +
Sbjct: 175 VVAPGFVHTDMTKDL-----KEEHLKKNIPLGRFGETIEVAHAVVFLL--ESPYITGHVL 227

Query: 272 MVGGG 276
           +V GG
Sbjct: 228 VVDGG 232


>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
          Length = 303

 Score = 94.7 bits (234), Expect = 8e-20
 Identities = 73/255 (28%), Positives = 121/255 (47%), Gaps = 14/255 (5%)

Query: 30  LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQG-----EGLSMT 84
           L  +VA+VT     IG A+ + L + G++VV++ RK + +  A   LQ      +   + 
Sbjct: 16  LQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQARVI 75

Query: 85  GTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDIN 144
              C++   ++   LV + +   G I+ L     N+  G F       + + W   L+ N
Sbjct: 76  PIQCNIRNEEEVNNLVKSTLDTFGKINFL----VNNGGGQFLSPAEHISSKGWHAVLETN 131

Query: 145 GKALALMIKAVVPE-MEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIEL 203
                 M KAV    M++ GG  V  +    A  PL   S    ++  +  L K+LA+E 
Sbjct: 132 LTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHS--GAARAGVYNLTKSLALEW 189

Query: 204 APRNIRVNCLAPGLI--KTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSE 261
           A   IR+NC+APG+I  +T+        +   E   + +  +R+G PE+   +V FL S 
Sbjct: 190 ACSGIRINCVAPGVIYSQTAVENYGSWGQSFFEGSFQKIPAKRIGVPEEVSSVVCFLLSP 249

Query: 262 DASYLTGETVMVGGG 276
            AS++TG++V V GG
Sbjct: 250 AASFITGQSVDVDGG 264


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 75/248 (30%), Positives = 118/248 (47%), Gaps = 13/248 (5%)

Query: 30  LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCH 89
           L  +  LVT +   IG    Q L   GA VV   R Q ++D  V    G        VC 
Sbjct: 5   LAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSLVRECPG-----IEPVCV 59

Query: 90  VGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALA 149
              + DWE   AT   L G +  + L + N+   L     L+  +EA+DR+ ++N +A+ 
Sbjct: 60  --DLGDWE---ATERAL-GSVGPVDLLVNNAAVALLQ-PFLEVTKEAFDRSFEVNLRAVI 112

Query: 150 LMIKAVVPEMEKRG-GGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNI 208
            + + V   +  RG  G++  ++S  + R +   S Y  +K AL  L K +A+EL P  I
Sbjct: 113 QVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELGPHKI 172

Query: 209 RVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDASYLTG 268
           RVN + P ++ TS  +  W D  K ++M   + + +  E E  +  + FL S+ +   TG
Sbjct: 173 RVNAVNPTVVMTSMGQATWSDPHKAKTMLNRIPLGKFAEVEHVVNAILFLLSDRSGMTTG 232

Query: 269 ETVMVGGG 276
            T+ V GG
Sbjct: 233 STLPVEGG 240


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 92.0 bits (227), Expect = 5e-19
 Identities = 79/253 (31%), Positives = 120/253 (47%), Gaps = 9/253 (3%)

Query: 30  LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTV-- 87
           L + +ALVT +   IG AV+ RLA +GA V      +    + V  L G G S  G    
Sbjct: 9   LRSALALVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQETVRLLGGPG-SKEGPPRG 67

Query: 88  CHVGKMKDWERLVATAMKLHGVIDILSL--SITNSKRGLFWFT-LLQTAEEAWDRNLDIN 144
            H     D     A    L  V    S   S+  S  G+     LL  +E+ WD+ + +N
Sbjct: 68  NHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAVN 127

Query: 145 GKALALMIKAVVPEMEKRG-GGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIEL 203
            K   L+ +A    +   G  GS+  ++S+       G + Y  SK  ++GL +T A EL
Sbjct: 128 LKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTNYAASKAGVIGLTQTAAREL 187

Query: 204 APRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDA 263
               IR N + PG I T  ++   + ++  + + E + +  LG+PED   +V+FL SED+
Sbjct: 188 GRHGIRCNSVLPGFIATPMTQK--VPQKVVDKITEMIPMGHLGDPEDVADVVAFLASEDS 245

Query: 264 SYLTGETVMVGGG 276
            Y+TG +V V GG
Sbjct: 246 GYITGTSVEVTGG 258


>gi|66933014 3-hydroxybutyrate dehydrogenase, type 2 [Homo sapiens]
          Length = 245

 Score = 89.4 bits (220), Expect = 3e-18
 Identities = 65/252 (25%), Positives = 128/252 (50%), Gaps = 18/252 (7%)

Query: 30  LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCH 89
           L  KV ++TA+   IG A A   A++GA V+ +   +  + Q +    G    +   V  
Sbjct: 4   LDGKVIILTAAAQGIGQAAALAFAREGAKVIATDINESKL-QELEKYPG----IQTRVLD 58

Query: 90  VGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALA 149
           V K K  ++      +L  + ++           +   T+L   E+ WD ++++N +++ 
Sbjct: 59  VTKKKQIDQFANEVERLDVLFNVAGF--------VHHGTVLDCEEKDWDFSMNLNVRSMY 110

Query: 150 LMIKAVVPEMEKRGGGSVGFLASVA-AFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNI 208
           LMIKA +P+M  +  G++  ++SVA + + +     Y+ +K A++GL K++A +   + I
Sbjct: 111 LMIKAFLPKMLAQKSGNIINMSSVASSVKGVVNRCVYSTTKAAVIGLTKSVAADFIQQGI 170

Query: 209 RVNCLAPGLIKT-SFSRMLWMDKEKEESMKETLRIRRLGE---PEDSLGIVSFLCSEDAS 264
           R NC+ PG + T S    +      EE+  + L+ ++ G     E+   +  +L S++++
Sbjct: 171 RCNCVCPGTVDTPSLQERIQARGNPEEARNDFLKRQKTGRFATAEEIAMLCVYLASDESA 230

Query: 265 YLTGETVMVGGG 276
           Y+TG  V++ GG
Sbjct: 231 YVTGNPVIIDGG 242


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 71/264 (26%), Positives = 124/264 (46%), Gaps = 21/264 (7%)

Query: 19  LASSGMTRRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQG 78
           +A  GM R     +++ALVT ++  IG AVA+ L Q G  VV   R   N+++  A  + 
Sbjct: 1   MARPGMER---WRDRLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEELAAECKS 57

Query: 79  EGLSMTGTV----CHVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAE 134
            G    GT+    C +   +D   + +     H  +DI   +   ++      TLL  + 
Sbjct: 58  AG--YPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPD----TLLSGST 111

Query: 135 EAWDRNLDINGKALALMIKAVVPEMEKRG--GGSVGFLASVAAFR--PLPGFSPYNVSKT 190
             W    ++N  AL++  +     M++R    G +  + S++  R  PL     Y+ +K 
Sbjct: 112 SGWKDMFNVNVLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHFYSATKY 171

Query: 191 ALLGLNKTLAIEL--APRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEP 248
           A+  L + L  EL  A  +IR  C++PG+++T F+  L  DK+ E++     +++ L +P
Sbjct: 172 AVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKL-HDKDPEKAAATYEQMKCL-KP 229

Query: 249 EDSLGIVSFLCSEDASYLTGETVM 272
           ED    V ++ S  A    G+  M
Sbjct: 230 EDVAEAVIYVLSTPAHIQIGDIQM 253


>gi|10190704 2,4-dienoyl CoA reductase 2 [Homo sapiens]
          Length = 292

 Score = 68.9 bits (167), Expect = 5e-12
 Identities = 71/255 (27%), Positives = 106/255 (41%), Gaps = 14/255 (5%)

Query: 28  DPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTV 87
           D L +KVA +T     IGF +A+   + G H V++ R    V  A   L G     TG  
Sbjct: 24  DLLRDKVAFITGGGSGIGFRIAEIFMRHGCHTVIASRSLPRVLTAARKLAG----ATGRR 79

Query: 88  C-----HVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLD 142
           C      V         V  A+K  G IDIL     N   G F       +  A+   +D
Sbjct: 80  CLPLSMDVRAPPAVMAAVDQALKEFGRIDIL----INCAAGNFLCPAGALSFNAFKTVMD 135

Query: 143 INGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIE 202
           I+      + + +  +  +  GG +  + +    R          +K A+  + + LA+E
Sbjct: 136 IDTSGTFNVSRVLYEKFFRDHGGVIVNITATLGNRGQALQVHAGSAKAAVDAMTRHLAVE 195

Query: 203 LAPRNIRVNCLAPGLIK-TSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSE 261
             P+NIRVN LAPG I  T   R L   +    +      ++RLG   +    V +L S 
Sbjct: 196 WGPQNIRVNSLAPGPISGTEGLRRLGGPQASLSTKVTASPLQRLGNKTEIAHSVLYLASP 255

Query: 262 DASYLTGETVMVGGG 276
            ASY+TG  ++  GG
Sbjct: 256 LASYVTGAVLVADGG 270


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 66.2 bits (160), Expect = 3e-11
 Identities = 59/248 (23%), Positives = 112/248 (45%), Gaps = 13/248 (5%)

Query: 33  KVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVGK 92
           KV +VT     IG  + +     GA VV+  + +         L G    +    C V +
Sbjct: 10  KVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELPGAVFIL----CDVTQ 65

Query: 93  MKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALALMI 152
             D + LV+  ++  G +D +   + N+          +T+ + + + L++N      + 
Sbjct: 66  EDDVKTLVSETIRRFGRLDCV---VNNAGHHPPPQRPEETSAQGFRQLLELNLLGTYTLT 122

Query: 153 KAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNIRVNC 212
           K  +P + K  G  +   + V A        PY  +K A+  + K LA++ +P  +RVNC
Sbjct: 123 KLALPYLRKSQGNVINISSLVGAIGQAQAV-PYVATKGAVTAMTKALALDESPYGVRVNC 181

Query: 213 LAPGLIKTS-FSRMLWMDKEKEESMKETL---RIRRLGEPEDSLGIVSFLCSEDASYLTG 268
           ++PG I T  +  +  +  +   +++E +    + R+G+P +      FL SE A++ TG
Sbjct: 182 ISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASE-ANFCTG 240

Query: 269 ETVMVGGG 276
             ++V GG
Sbjct: 241 IELLVTGG 248


>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 59/201 (29%), Positives = 102/201 (50%), Gaps = 14/201 (6%)

Query: 26  RRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTG 85
           R + L  K  +VT ++  IG  +A  LA+ GAHVVV+ R ++ + + V+     G +   
Sbjct: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87

Query: 86  TVCHVGKMKDW---ERLVATAMKLHGVIDILSLS-ITNSKRGLFWFTLLQTAEEAWDRNL 141
            +   G M+D    E+ VA A KL G +D+L L+ ITN+   LF   +         +++
Sbjct: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVR-----KSM 140

Query: 142 DINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAI 201
           ++N  +  ++  A +P M K+  GS+  ++S+A     P  + Y+ SK AL G   ++  
Sbjct: 141 EVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRK 199

Query: 202 E--LAPRNIRVNCLAPGLIKT 220
           E  ++  N+ +     GLI T
Sbjct: 200 EYSVSRVNVSITLCVLGLIDT 220


>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
          Length = 292

 Score = 65.9 bits (159), Expect = 4e-11
 Identities = 59/201 (29%), Positives = 102/201 (50%), Gaps = 14/201 (6%)

Query: 26  RRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTG 85
           R + L  K  +VT ++  IG  +A  LA+ GAHVVV+ R ++ + + V+     G +   
Sbjct: 28  RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAH 87

Query: 86  TVCHVGKMKDW---ERLVATAMKLHGVIDILSLS-ITNSKRGLFWFTLLQTAEEAWDRNL 141
            +   G M+D    E+ VA A KL G +D+L L+ ITN+   LF   +         +++
Sbjct: 88  YI--AGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVR-----KSM 140

Query: 142 DINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAI 201
           ++N  +  ++  A +P M K+  GS+  ++S+A     P  + Y+ SK AL G   ++  
Sbjct: 141 EVNFLSYVVLTVAALP-MLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRK 199

Query: 202 E--LAPRNIRVNCLAPGLIKT 220
           E  ++  N+ +     GLI T
Sbjct: 200 EYSVSRVNVSITLCVLGLIDT 220


>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
           [Homo sapiens]
          Length = 261

 Score = 64.3 bits (155), Expect = 1e-10
 Identities = 71/256 (27%), Positives = 109/256 (42%), Gaps = 26/256 (10%)

Query: 34  VALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKM 93
           VA++T     +G A A+RL   GA  V+        +     L   G +       V   
Sbjct: 12  VAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKL---GNNCVFAPADVTSE 68

Query: 94  KDWERLVATAMKLHGVIDI--------LSLSITNSKRGLFWFTLLQTAEEAWDRNLDING 145
           KD +  +A A    G +D+        ++    N K+G        T E+ + R LD+N 
Sbjct: 69  KDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQ-----THTLED-FQRVLDVNL 122

Query: 146 KALALMIKAVVPEM---EKRGGGSVGFL---ASVAAFRPLPGFSPYNVSKTALLGLNKTL 199
                +I+ V  EM   E   GG  G +   ASVAAF    G + Y+ SK  ++G+   +
Sbjct: 123 MGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPI 182

Query: 200 AIELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLC 259
           A +LAP  IRV  +APGL  T     L  +K       +     RLG+P +   +V  + 
Sbjct: 183 ARDLAPIGIRVMTIAPGLFGTPLLTSL-PEKVCNFLASQVPFPSRLGDPAEYAHLVQAII 241

Query: 260 SEDASYLTGETVMVGG 275
             +  +L GE + + G
Sbjct: 242 --ENPFLNGEVIRLDG 255


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 63.9 bits (154), Expect = 1e-10
 Identities = 50/200 (25%), Positives = 90/200 (45%), Gaps = 7/200 (3%)

Query: 26  RRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTG 85
           RR  +T ++ L+T +   IG   A   A+  + +V+    +  +++  A  +G G  +  
Sbjct: 30  RRKSVTGEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEETAAKCKGLGAKVHT 89

Query: 86  TVCHVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDING 145
            V      +D   + ++A K+   I  +S+ + N+   ++   L  T +   ++  ++N 
Sbjct: 90  FVVDCSNRED---IYSSAKKVKAEIGDVSILVNNAGV-VYTSDLFATQDPQIEKTFEVNV 145

Query: 146 KALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAP 205
            A     KA +P M K   G +  +AS A    +P    Y  SK A +G +KTL  ELA 
Sbjct: 146 LAHFWTTKAFLPAMTKNNHGHIVTVASAAGHVSVPFLLAYCSSKFAAVGFHKTLTDELAA 205

Query: 206 ---RNIRVNCLAPGLIKTSF 222
                ++  CL P  + T F
Sbjct: 206 LQITGVKTTCLCPNFVNTGF 225


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 62.8 bits (151), Expect = 3e-10
 Identities = 52/222 (23%), Positives = 97/222 (43%), Gaps = 11/222 (4%)

Query: 26  RRDPLTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTG 85
           RR  +  ++ L+T +   IG       A+  + +V+    ++ V++  A  +  G++   
Sbjct: 30  RRKSVAGEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRKLGVTAHA 89

Query: 86  TVCHVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDING 145
            V      ++  R +    K  G + I    + N+   ++   LL T +E   +  ++N 
Sbjct: 90  YVVDCSNREEIYRSLNQVKKEVGDVTI----VVNNAGTVYPADLLSTKDEEITKTFEVNI 145

Query: 146 KALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIE--- 202
                + KA++P M +R  G +  +ASV     +P   PY  SK A +G ++ L  E   
Sbjct: 146 LGHFWITKALLPSMMERNHGHIVTVASVCGHEGIPYLIPYCSSKFAAVGFHRGLTSELQA 205

Query: 203 LAPRNIRVNCLAPGLIKTSF----SRMLWMDKEKEESMKETL 240
           L    I+ +CL P  + T F    S  LW   E +E ++  +
Sbjct: 206 LGKTGIKTSCLCPVFVNTGFTKNPSTRLWPVLETDEVVRSLI 247


>gi|4503301 2,4-dienoyl CoA reductase 1 precursor [Homo sapiens]
          Length = 335

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 62/248 (25%), Positives = 104/248 (41%), Gaps = 9/248 (3%)

Query: 33  KVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGE-GLSMTGTVCHVG 91
           KVA +T     +G  +   L+  GA  V++ RK   +      +  + G  +    C V 
Sbjct: 60  KVAFITGGGTGLGKGMTTLLSSLGAQCVIASRKMDVLKATAEQISSQTGNKVHAIQCDVR 119

Query: 92  KMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALALM 151
                +  V+  +K+ G  +I    + N+  G F     + +  AW    DI     A +
Sbjct: 120 DPDMVQNTVSELIKVAGHPNI----VINNAAGNFISPTERLSPNAWKTITDIVLNGTAFV 175

Query: 152 IKAVVPEMEKRGGGSVGFLASVAAFRPLPGFS-PYNVSKTALLGLNKTLAIELAPRNIRV 210
              +  ++ K   G+     +        GF  P   +K  +  ++K+LA E     +R 
Sbjct: 176 TLEIGKQLIKAQKGAAFLSITTIYAETGSGFVVPSASAKAGVEAMSKSLAAEWGKYGMRF 235

Query: 211 NCLAPGLIKT--SFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDASYLTG 268
           N + PG IKT  +FSR L      E+ M   +   RLG  E+   + +FLCS+ AS++ G
Sbjct: 236 NVIQPGPIKTKGAFSR-LDPTGTFEKEMIGRIPCGRLGTVEELANLAAFLCSDYASWING 294

Query: 269 ETVMVGGG 276
             +   GG
Sbjct: 295 AVIKFDGG 302


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 53/196 (27%), Positives = 89/196 (45%), Gaps = 7/196 (3%)

Query: 33  KVALVTASTDWIGFAVAQRLAQDGA--HVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHV 90
           +  L++  +  IG  +A +LA D    + VV+  +     + +    GE L  T TV  +
Sbjct: 6   RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQL 65

Query: 91  GKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALAL 150
               D E +      + G +D+L   + N+  GL    L   +  A     D N      
Sbjct: 66  DVCSD-ESVAQCLSCIQGEVDVL---VNNAGMGLVG-PLEGLSLAAMQNVFDTNFFGAVR 120

Query: 151 MIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNIRV 210
           ++KAV+P M++R  G +  ++SV   + +     Y  SK AL G  ++LAI+L   NI +
Sbjct: 121 LVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFNIFI 180

Query: 211 NCLAPGLIKTSFSRML 226
           + + PG + T F   L
Sbjct: 181 SLVEPGPVVTEFEGKL 196


>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
           sapiens]
          Length = 328

 Score = 57.4 bits (137), Expect = 1e-08
 Identities = 56/204 (27%), Positives = 92/204 (45%), Gaps = 22/204 (10%)

Query: 30  LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGL---SMTGT 86
           +   V L+T  +  IG  +A RLA D +       +   V   +  L+ +G    +    
Sbjct: 1   MARTVVLITGCSSGIGLHLAVRLASDPS-------QSFKVYATLRDLKTQGRLWEAARAL 53

Query: 87  VCHVGKMKDWE------RLVATAMK--LHGVIDILSLSITNSKRGLFWFTLLQTAEEAWD 138
            C  G ++  +      + VA A +    G +D+L   + N+  GL    L    E+A  
Sbjct: 54  ACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVL---VCNAGLGLLG-PLEALGEDAVA 109

Query: 139 RNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKT 198
             LD+N      M++A +P+M++RG G V    SV     LP    Y  SK AL GL ++
Sbjct: 110 SVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCES 169

Query: 199 LAIELAPRNIRVNCLAPGLIKTSF 222
           LA+ L P  + ++ +  G + T+F
Sbjct: 170 LAVLLLPFGVHLSLIECGPVHTAF 193


>gi|239756089 PREDICTED: similar to hCG1645561 [Homo sapiens]
          Length = 41

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 28/41 (68%), Positives = 33/41 (80%)

Query: 36 LVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATL 76
          ++T ST+  GFA+AQRLA D AHVV+S  KQQNVD AVATL
Sbjct: 1  MITGSTNRFGFAIAQRLAHDRAHVVISSGKQQNVDWAVATL 41


>gi|239750620 PREDICTED: similar to hCG1645561 [Homo sapiens]
          Length = 41

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 28/41 (68%), Positives = 33/41 (80%)

Query: 36 LVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATL 76
          ++T ST+  GFA+AQRLA D AHVV+S  KQQNVD AVATL
Sbjct: 1  MITGSTNRFGFAIAQRLAHDRAHVVISSGKQQNVDWAVATL 41


>gi|239744927 PREDICTED: similar to hCG1645561 [Homo sapiens]
          Length = 41

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 28/41 (68%), Positives = 33/41 (80%)

Query: 36 LVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATL 76
          ++T ST+  GFA+AQRLA D AHVV+S  KQQNVD AVATL
Sbjct: 1  MITGSTNRFGFAIAQRLAHDRAHVVISSGKQQNVDWAVATL 41


>gi|226371731 hydroxysteroid dehydrogenase like 1 isoform a [Homo
           sapiens]
          Length = 330

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 46/194 (23%), Positives = 92/194 (47%), Gaps = 12/194 (6%)

Query: 35  ALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMK 94
           A+V+ +TD IG A A+ LA  G ++++  R ++ +      +       T  +     + 
Sbjct: 70  AVVSGATDGIGKAYAEELASRGLNIILISRNEEKLQVVAKDIADTYKVETDII-----VA 124

Query: 95  DWERLVATAMKLHGVIDILSLSITNSKRGLFW-----FTLLQTAEEAWDRNLDINGKALA 149
           D+       + +   +    + I  +  G+F+     FT L + ++ WD  +++N  A +
Sbjct: 125 DFSSGREIYLPIREALKDKDVGILVNNVGVFYPYPQYFTQL-SEDKLWDI-INVNIAAAS 182

Query: 150 LMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNIR 209
           LM+  V+P M +R  G++  ++S +  +P P  + ++ SK  L   ++ L  E A + I 
Sbjct: 183 LMVHVVLPGMVERKKGAIVTISSGSCCKPTPQLAAFSASKAYLDHFSRALQYEYASKGIF 242

Query: 210 VNCLAPGLIKTSFS 223
           V  L P  + TS +
Sbjct: 243 VQSLIPFYVATSMT 256


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 55.1 bits (131), Expect = 7e-08
 Identities = 67/258 (25%), Positives = 111/258 (43%), Gaps = 29/258 (11%)

Query: 33  KVALVTASTDWIGFAVAQRLAQDGAHVVVSR---------RKQQNVDQAVATLQGEGLSM 83
           +V LVT +   +G A A   A+ GA VVV+          +     D+ V  ++  G   
Sbjct: 10  RVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIRRRGGK- 68

Query: 84  TGTVCHVGKMKDWERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDI 143
              V +   +++ E++V TA+   G ID+    + N+   L   +  + ++E WD    +
Sbjct: 69  --AVANYDSVEEGEKVVKTALDAFGRIDV----VVNNAGILRDRSFARISDEDWDIIHRV 122

Query: 144 NGKALALMIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIEL 203
           + +    + +A    M+K+  G +   +S +      G + Y+ +K  LLGL  +LAIE 
Sbjct: 123 HLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANSLAIEG 182

Query: 204 APRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIRRLGEPEDSLGIVSFLCSEDA 263
              NI  N +AP     + SRM        E + E L+      PE    +V +LC E  
Sbjct: 183 RKSNIHCNTIAP----NAGSRM--TQTVMPEDLVEALK------PEYVAPLVLWLCHESC 230

Query: 264 SYLTGETVMVGGGTPSRL 281
               G    VG G   +L
Sbjct: 231 EE-NGGLFEVGAGWIGKL 247


>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
          Length = 312

 Score = 54.7 bits (130), Expect = 9e-08
 Identities = 47/192 (24%), Positives = 94/192 (48%), Gaps = 3/192 (1%)

Query: 35  ALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVCHVGKMK 94
           A+VT STD IG + A+ LA+ G  VV+  R +  +DQ  + ++ +    T T+      +
Sbjct: 53  AVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKEKFKVETRTIAVDFASE 112

Query: 95  DWERLVATAMKLHGV-IDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALALMIK 153
           D    + T   L G+ I IL  ++  S     +F  +   +    + ++IN  ++  M +
Sbjct: 113 DIYDKIKTG--LAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININILSVCKMTQ 170

Query: 154 AVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNIRVNCL 213
            V+P M +R  G++  ++S +   P+P  + Y+ +KT +   ++ L  E   + + V  +
Sbjct: 171 LVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSV 230

Query: 214 APGLIKTSFSRM 225
            P  + T  +++
Sbjct: 231 LPYFVATKLAKI 242


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 53.5 bits (127), Expect = 2e-07
 Identities = 56/223 (25%), Positives = 90/223 (40%), Gaps = 27/223 (12%)

Query: 30  LTNKVALVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATL--QGEGLSMTGTV 87
           +  KVALVT +   IG A A+ L   GA V +     +   Q  A L  Q E        
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNLEAGVQCKAALDEQFEPQKTLFIQ 62

Query: 88  CHVGKMKDWERLVATAMKLHGVIDIL--SLSITNSKRGLFWFTLLQTAEEAWDRNLDING 145
           C V   +         +   G +DIL  +  + N K               W++ L IN 
Sbjct: 63  CDVADQQQLRDTFRKVVDHFGRLDILVNNAGVNNEKN--------------WEKTLQINL 108

Query: 146 KALALMIKAVVPEMEKRGGGSVGF---LASVAAFRPLPGFSPYNVSKTALLGLNKT--LA 200
            ++       +  M K+ GG  G    ++S+A   P+     Y  SK  ++G  ++  LA
Sbjct: 109 VSVISGTYLGLDYMSKQNGGEGGIIINMSSLAGLMPVAQQPVYCASKHGIVGFTRSAALA 168

Query: 201 IELAPRNIRVNCLAPGLIKTSFSRMLWMDKEKEESMKETLRIR 243
             L    +R+N + PG + T+    +    EKEE+M + +  +
Sbjct: 169 ANLMNSGVRLNAICPGFVNTAILESI----EKEENMGQYIEYK 207


>gi|210032112 hydroxysteroid (17-beta) dehydrogenase 13 isoform B
           [Homo sapiens]
          Length = 264

 Score = 53.1 bits (126), Expect = 3e-07
 Identities = 36/131 (27%), Positives = 61/131 (46%), Gaps = 7/131 (5%)

Query: 117 ITNSKRGLFWFTLLQTAEEAWDRNLDINGKALALMIKAVVPEMEKRGGGSVGFLASVAAF 176
           + N+   ++   LL T +E   +  ++N      + KA++P M +R  G +  +ASV   
Sbjct: 81  VVNNAGTVYPADLLSTKDEEITKTFEVNILGHFWITKALLPSMMERNHGHIVTVASVCGH 140

Query: 177 RPLPGFSPYNVSKTALLGLNKTLAIE---LAPRNIRVNCLAPGLIKTSF----SRMLWMD 229
             +P   PY  SK A +G ++ L  E   L    I+ +CL P  + T F    S  LW  
Sbjct: 141 EGIPYLIPYCSSKFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKNPSTRLWPV 200

Query: 230 KEKEESMKETL 240
            E +E ++  +
Sbjct: 201 LETDEVVRSLI 211


>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
           sapiens]
          Length = 332

 Score = 52.4 bits (124), Expect = 4e-07
 Identities = 47/185 (25%), Positives = 84/185 (45%), Gaps = 9/185 (4%)

Query: 36  LVTASTDWIGFAVAQRLAQDGAHVVVSRRKQQNVDQAVATLQGEGLSMTGTVC--HVGKM 93
           +VT  +  IG  +A    + GA + +  R +  + QA   ++   ++    V    V   
Sbjct: 36  VVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVS 95

Query: 94  KDW---ERLVATAMKLHGVIDILSLSITNSKRGLFWFTLLQTAEEAWDRNLDINGKALAL 150
           +D+   E ++  A +  G +D+L      +  G F    + T E    R + IN      
Sbjct: 96  QDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFE----RLMSINYLGSVY 151

Query: 151 MIKAVVPEMEKRGGGSVGFLASVAAFRPLPGFSPYNVSKTALLGLNKTLAIELAPRNIRV 210
             +AV+  M++R  G + F++S A    L GF+ Y+ SK A+ GL + L +E+ P N+ +
Sbjct: 152 PSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYI 211

Query: 211 NCLAP 215
               P
Sbjct: 212 TVAYP 216


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.133    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 9,738,782
Number of Sequences: 37866
Number of extensions: 387975
Number of successful extensions: 1033
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 948
Number of HSP's gapped (non-prelim): 64
length of query: 281
length of database: 18,247,518
effective HSP length: 101
effective length of query: 180
effective length of database: 14,423,052
effective search space: 2596149360
effective search space used: 2596149360
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.