Guide to the Human Genome
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Search of human proteins with 4505101

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4505101 microtubule-associated protein 7 [Homo sapiens]
         (749 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4505101 microtubule-associated protein 7 [Homo sapiens]           1471   0.0  
gi|78042577 MAP7 domain containing 1 [Homo sapiens]                   391   e-108
gi|22758136 MAP7 domain containing 2 [Homo sapiens]                   279   8e-75
gi|147903302 MAP7 domain containing 3 [Homo sapiens]                  155   1e-37
gi|148746195 trichohyalin [Homo sapiens]                               90   7e-18
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap...    89   1e-17
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap...    89   1e-17
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap...    89   1e-17
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi...    89   1e-17
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            88   3e-17
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            84   6e-16
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       82   1e-15
gi|102467242 inner centromere protein antigens 135/155kDa isofor...    81   3e-15
gi|4503509 eukaryotic translation initiation factor 3, subunit 1...    81   4e-15
gi|102467235 inner centromere protein antigens 135/155kDa isofor...    80   5e-15
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     80   7e-15
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        80   9e-15
gi|22035606 mitogen-activated protein kinase kinase kinase kinas...    79   1e-14
gi|22035602 mitogen-activated protein kinase kinase kinase kinas...    79   2e-14
gi|22035604 mitogen-activated protein kinase kinase kinase kinas...    79   2e-14
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    78   3e-14
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi...    77   4e-14
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    77   4e-14
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m...    77   6e-14
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m...    77   6e-14
gi|7661936 scaffold attachment factor B2 [Homo sapiens]                77   6e-14
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ...    77   8e-14
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    76   1e-13
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    76   1e-13
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]            76   1e-13

>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
          Length = 749

 Score = 1471 bits (3809), Expect = 0.0
 Identities = 749/749 (100%), Positives = 749/749 (100%)

Query: 1   MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV 60
           MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV
Sbjct: 1   MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV 60

Query: 61  LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
           LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR
Sbjct: 61  LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120

Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
           RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR
Sbjct: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180

Query: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 240
           SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS
Sbjct: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 240

Query: 241 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER 300
           KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER
Sbjct: 241 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER 300

Query: 301 ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ 360
           ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ
Sbjct: 301 ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ 360

Query: 361 VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP 420
           VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP
Sbjct: 361 VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP 420

Query: 421 EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT 480
           EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT
Sbjct: 421 EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT 480

Query: 481 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
           RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR
Sbjct: 481 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 540

Query: 541 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
           EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK
Sbjct: 541 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600

Query: 601 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV 660
           KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV
Sbjct: 601 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV 660

Query: 661 VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN 720
           VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN
Sbjct: 661 VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN 720

Query: 721 PILAFDDEGTLGPLPQVDGVQTQQTAEVI 749
           PILAFDDEGTLGPLPQVDGVQTQQTAEVI
Sbjct: 721 PILAFDDEGTLGPLPQVDGVQTQQTAEVI 749


>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
          Length = 841

 Score =  391 bits (1005), Expect = e-108
 Identities = 269/648 (41%), Positives = 353/648 (54%), Gaps = 95/648 (14%)

Query: 51  SGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL 110
           S + P    V +  +R +LA+ERREER K LAA++ VWLE+EE+A+   EK L+ER++RL
Sbjct: 123 SDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL 182

Query: 111 EEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSP 170
           EEQR K E+RRAA+EE++RQ+LE++KER+EA ++R+++++   + +  RWSW G+LH S 
Sbjct: 183 EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWA-EIRQQRWSWAGALHHSS 241

Query: 171 SIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLL 230
             H     R SVS +NL K+VD +I+KRLS SSATL NSP R R LQLS WESS+V+RL+
Sbjct: 242 PGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLM 301

Query: 231 TPTHSFLARSKSTAAL-------------------------------------------S 247
           TPT SFLARS+S   L                                            
Sbjct: 302 TPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVC 361

Query: 248 GEAASCSPI--------IMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERE 299
             +AS SP+        +     A  R    +P    +P     R          KK++E
Sbjct: 362 PRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKE 421

Query: 300 REN------VLFLTSGTRRAVSPSNPKARQPA--RSRLWLPSKSLPHLPGTP--RPTSSL 349
           REN      +    S  +R   P++P+AR  A   S L   SK+ P  P T   RP S  
Sbjct: 422 RENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPC 481

Query: 350 P-PGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVE 408
           P PG     P    PP P + R      K    +K+  KE       PS  G     + +
Sbjct: 482 PSPG-----PGHTLPPKPPSPRGTTASPKGRVRRKEEAKE------SPSAAGPEDKSQSK 530

Query: 409 EATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTP---AMVSAPSSTVNASA 465
                E+  A     PA+PA +PAP+  PAP     P P  TP   A++++P +      
Sbjct: 531 RRASNEKESA----APASPAPSPAPSPTPAPPQKEQP-PAETPTDAAVLTSPPAPAPPVT 585

Query: 466 SVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTT 525
             K  AGTTD EEATRLLAEKRR AREQRE+EE+ERR Q E +++ REE   R AE R  
Sbjct: 586 PSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEAR-A 644

Query: 526 RREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE-EARVREEAERVRQE 584
            RE E+RR E ++AREK           A  E+EE ER Q+QKEE EAR REEAER R E
Sbjct: 645 EREAEARRREEQEAREK-----------AQAEQEEQERLQKQKEEAEARSREEAERQRLE 693

Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGA 632
           REKHFQ++EQER ER+KRLEEIMKRTR++E ++ K         A G+
Sbjct: 694 REKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGS 741



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 64/237 (27%), Positives = 105/237 (44%), Gaps = 30/237 (12%)

Query: 350 PPGSVKAAPAQVRPPSPGNIRP----VKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLV 405
           PP  V   P + RP   G+  P    +   V   P    P  +    + +  L+  +P  
Sbjct: 14  PPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSG 73

Query: 406 KV--EEATVEERTPAEPEV--GPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTV 461
           +V    A  +E +P+      GP  PAM P  A  P  +S P+P  V  PA  S P+   
Sbjct: 74  QVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV--PASDSPPT--- 128

Query: 462 NASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVA 520
                          ++  +   E+ +LA+E+RE+  +    ++ +  +K E+  A R  
Sbjct: 129 ---------------KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREK 173

Query: 521 EERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREE 577
           + +  RR  E +RL+AEQ R   E+ QRQ  E+  +ER EA   +  K+  A +R++
Sbjct: 174 QLQERRRRLEEQRLKAEQRRAALEERQRQKLEKN-KERYEAAIQRSVKKTWAEIRQQ 229



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 59/227 (25%), Positives = 98/227 (43%), Gaps = 33/227 (14%)

Query: 401 RAPLVKVEEATVEERTPAEPEVGPAA-PAMAPAPASAPAPASAPAPAPV--------PTP 451
           RA L       V  RTP EP   P   P+  P P SA  P + P   P           P
Sbjct: 6   RAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLP 65

Query: 452 AMVSAPSSTV---------NASASVKTSAGTTDPEEATRLLAEKRRLAREQ--------- 493
               +PS  V          + +S   S G T P    R     RR ++           
Sbjct: 66  LEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDS 125

Query: 494 --REKEERERREQEELERQKREELAQRVAEERTT--RREEESRRLEAEQAREKEEQLQRQ 549
              ++E ++  E+ +L +++REE A+ +A ++     +EE+++ L  +Q +E+  +L+ Q
Sbjct: 126 PPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQ 185

Query: 550 AEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQER 596
              +A + R   E  QRQK E+ + R EA  +++  +K +    Q+R
Sbjct: 186 -RLKAEQRRAALEERQRQKLEKNKERYEA-AIQRSVKKTWAEIRQQR 230



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 66/288 (22%), Positives = 122/288 (42%), Gaps = 36/288 (12%)

Query: 421 EVGPAAPAMAPA---PASAPAPASAPAPAPVPTPAMV-----SAPSSTVNASASVKTSAG 472
           E+G  AP    A   P   P+P   P+P P P  A+V       P +  NA++S +    
Sbjct: 8   ELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPL- 66

Query: 473 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEES- 531
             +PE  +  +  +    +E+    E + R         R+    R + + +      S 
Sbjct: 67  --EPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASD 124

Query: 532 ---RRLEAEQAREKEEQLQRQAEERALR---------EREEAERAQRQKE-EEARVREEA 578
               + E ++A E+ +  + + EERA           E+EE  +A R+K+ +E R R E 
Sbjct: 125 SPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE 184

Query: 579 ERVR-QEREKHFQREEQERLERKKRLEE--IMKRTRRTEATDKKTSDQRNGDIAKGALTG 635
           +R++ ++R    +  ++++LE+ K   E  I +  ++T A  ++      G +     + 
Sbjct: 185 QRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHS--SP 242

Query: 636 GTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNEN 683
           G + S   C+ +A      V  P  V S  +K   +S+  L   P+ N
Sbjct: 243 GHKTSGSRCSVSA------VNLPKHVDSIINKRLSKSSATLWNSPSRN 284



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 26/110 (23%), Positives = 56/110 (50%), Gaps = 14/110 (12%)

Query: 64  DDRQRLARER-------REEREKQLAAREIVWLEREERARQHYEKHLEE-----RKKRLE 111
           ++++RL +++       REE E+Q   RE    +++E+ RQ   K LEE     RK  + 
Sbjct: 667 EEQERLQKQKEEAEARSREEAERQRLERE-KHFQQQEQERQERRKRLEEIMKRTRKSEVS 725

Query: 112 EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWS 161
           E +QK++ + A       + ++  + R   + +  +++ ++P  +  +WS
Sbjct: 726 ETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQK-EEPIPQEPQWS 774



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 24/95 (25%), Positives = 50/95 (52%), Gaps = 7/95 (7%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREE---RARQHYEKHLEERKKRLEEQRQK--EERR 120
           R+R  +E RE+ + +   +E +  ++EE   R+R+  E+   ER+K  ++Q Q+  E R+
Sbjct: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRK 710

Query: 121 R--AAVEEKRRQRLEEDKERHEAVVRRTMERSQKP 153
           R    ++  R+  + E K++ ++        S +P
Sbjct: 711 RLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEP 745


>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
          Length = 732

 Score =  279 bits (713), Expect = 8e-75
 Identities = 216/590 (36%), Positives = 317/590 (53%), Gaps = 94/590 (15%)

Query: 61  LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
           L+ D+RQRLA+ERREEREK LAARE   LE+++RAR  YEK +EER ++LEEQRQ+E+++
Sbjct: 49  LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108

Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
           RAAVEEKR+Q+L E++ER EA++RR++ER+Q+ + K  ++SWG  L   P  H A  D+ 
Sbjct: 109 RAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELK-KKYSWGAPLAIGPGGHDAC-DKL 166

Query: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 240
           S STM+L K  +P ++KRLSSS+  +  SPDR            V  RL           
Sbjct: 167 STSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFH---------VCPRL----------- 206

Query: 241 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSS---RRRIIHGTASYKKE 297
                     A   P+   YK++ +RN +++ K   T   G+    +  +  G AS  ++
Sbjct: 207 ----------APLGPLNPSYKSSPTRN-IEKKKATSTSTSGAGDVGKEALSGGEASLVEK 255

Query: 298 RERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAA 357
            +R        G R A S        P R   +  S  +P  P +P   S     +   +
Sbjct: 256 VKR--------GQRTATSLPVVNFGSPLRRCEF--SGGIPKRPSSP-VISKTATKAYPQS 304

Query: 358 PAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTP 417
           P   +PP PG+  PVK  +     +  P+++ +K   E S K R            E T 
Sbjct: 305 PKTTKPPYPGS--PVKYRLPALSGQDMPKRKAEK---EKSNKER------------EGTL 347

Query: 418 AEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPE 477
           A+   GP               +   A A         A     N++A  K +AGTTD  
Sbjct: 348 AQQAAGPQGEEALEKHVVDKHASEKHAAA---------AGGKAENSAALGKPTAGTTDAG 398

Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER-------------T 524
           EA ++LAEKRR AR Q+E+EE+ER E+EE +R +REEL ++  EER              
Sbjct: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER 458

Query: 525 TRREEESRRLEAEQAREKEEQLQRQAEERAL----REREEAERAQRQKEEEA---RVREE 577
            R+EEE ++ E E+ R+  E+ +R+AEE  L    +E+E+ E+A  +K++EA   + RE 
Sbjct: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREV 518

Query: 578 AERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDK-KTSDQRNG 626
           AE++R ERE+   + EQERLERKKR++EIMKRTR+++   + K  D + G
Sbjct: 519 AEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVG 568



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 48/166 (28%), Positives = 73/166 (43%), Gaps = 33/166 (19%)

Query: 441 SAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLA--EKRRLAREQREKEE 498
           S     P  T    S P       A V+TS     P+     L   E++RLA+E+R  EE
Sbjct: 8   SGTGSRPEGTARGTSLPGKIAEPGA-VRTSQPNYRPQGMEGFLKSDERQRLAKERR--EE 64

Query: 499 RER----REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERA 554
           RE+    REQ+ LE+QKR  L      E   R+ EE R                      
Sbjct: 65  REKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQR---------------------- 102

Query: 555 LREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
             +RE+ +RA  +++ + ++REE ER+     +  +R +Q  L++K
Sbjct: 103 --QREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 39/125 (31%), Positives = 66/125 (52%), Gaps = 11/125 (8%)

Query: 33  KNASSRPASAISGQNNNHSG-NKPDPPPVLRVDDRQRLARERREER-EKQLAAREIVWLE 90
           K+AS + A+A  G+  N +   KP        +  + LA +RR+ R +K+   +E V  E
Sbjct: 367 KHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKE 426

Query: 91  REERA-RQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMER 149
            ++R  R+  ++  EE + RLEE+ +K+E      EE++RQ  EE+K++ E   +R    
Sbjct: 427 EQDRLEREELKRKAEEERLRLEEEARKQE------EERKRQ--EEEKKKQEGEEKRKAGE 478

Query: 150 SQKPK 154
             K K
Sbjct: 479 EAKRK 483



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 51/201 (25%), Positives = 87/201 (43%), Gaps = 18/201 (8%)

Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
           PE   R  +   ++A     +  +     + +E   + +  QR+A+E   RREE  + L 
Sbjct: 14  PEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKE---RREEREKCLA 70

Query: 536 AEQAREKEEQLQRQAE-ERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
           A + +  E+Q + + + E+ + ER      QRQ+E++ R   E      E+ K   REE+
Sbjct: 71  AREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVE------EKRKQKLREEE 124

Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKP 654
           ERLE   R    ++RT++ E   K +        A  A+  G   +    +T+     KP
Sbjct: 125 ERLEAMMR--RSLERTQQLELKKKYSWG------APLAIGPGGHDACDKLSTSTMSLPKP 176

Query: 655 VGSPHVVTSHQSKVTVESTPD 675
              P       S V +  +PD
Sbjct: 177 TEPPMNKRLSSSTVAISYSPD 197


>gi|147903302 MAP7 domain containing 3 [Homo sapiens]
          Length = 876

 Score =  155 bits (392), Expect = 1e-37
 Identities = 208/863 (24%), Positives = 346/863 (40%), Gaps = 166/863 (19%)

Query: 2   AELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPD-PPPV 60
           A  GAGG        A     A +  K + K++  +R A+  S   N  S  KP     +
Sbjct: 6   AAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVATHSS---NIRSTFKPVIDGSM 62

Query: 61  LRVDDRQRLARERREEREKQLAA-REIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
           L+ D +QRLARERREE+ +Q  A +E   LE+E + +  YEK +EER+++L+E+++KEE+
Sbjct: 63  LKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQ 122

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ-KPKQKHNRWSWGGSLHGSPSIHSADPD 178
           RR A EEKR Q+ E  KE+  A++ RT+ER +     +  RWSWGGS   +    +A  +
Sbjct: 123 RRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTA--N 180

Query: 179 RRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLA 238
           +RS ST  L +    +I +++  SSA L NS     + +     SS +NR  +  HS  +
Sbjct: 181 KRSASTEKLEQGTSALI-RQMPLSSAGLQNS---VAKRKTDKERSSSLNRRDSNLHS--S 234

Query: 239 RSKSTAALSGEAASCSPIIMPYKAAHSR--------------NSMDRP----------KL 274
             K  A         +  +M Y     R              ++M  P          + 
Sbjct: 235 TDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELRAVMFPMSTMKIPPQTKVEESPLEK 294

Query: 275 FVTPPEGS---------------SRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNP 319
             TPP+ S               S             E   ++   ++      VS  + 
Sbjct: 295 VETPPKASVDAPPQVNVEVFCNTSMEASPKAGVGMAPEVSTDSFPVVSVDVSPVVSTYDS 354

Query: 320 KARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVE 379
           +    A   L + +     L   P+ +    P +   AP +V   S   +  V  E   E
Sbjct: 355 EMSMDASPELSIEALPKVDLETVPKVSIVASPEASLEAPPEV---SLEALPEVSVEAAPE 411

Query: 380 PEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPA---SA 436
              + P K   +VA + S+KG     +  EA+ E    A P+    A   A   A    A
Sbjct: 412 GSLEAPPKGSAEVAPKESVKGSPK--ESMEASPEAMVKASPKTSLEASMEASPKAKARDA 469

Query: 437 PAPASAPAPAPVP-TPAMVSAPSSTVNASASVKTSAGTTDPEEATR-------------- 481
           P  +     A +P     +S+ +     S+S + + G   P    R              
Sbjct: 470 PKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENACGLPSPISTNRQIQKNCPPSPLPLI 529

Query: 482 ------------LLAEKRRLAREQREKEERERREQEELERQKREELAQR----------- 518
                       ++  +  L+ +      ++++E       + E L+QR           
Sbjct: 530 SKQSPQTSFPYKIMPIQHTLSVQSASSTVKKKKETVSKTTNRCEALSQRHMIYEESGNKS 589

Query: 519 ----VAEERTTRREEESRRLEAEQAREKEEQLQR---------------------QAEE- 552
               +  E  T+   E RRL  EQ  ++EE+ QR                     QAE+ 
Sbjct: 590 TAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKSKDMAKEAVGGQAEDH 649

Query: 553 ---------------RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERL 597
                          +   ++E+ E   ++ + + + +EEA++ ++E E+   +  QERL
Sbjct: 650 LKLKDGQQQNETKKKKGWLDQEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERL 709

Query: 598 ERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTE----------VSALPCTTN 647
           ERKKR+EEIMKRTR+T+    K ++  + DI + A     E           SA+   T 
Sbjct: 710 ERKKRIEEIMKRTRKTDVNASKVTETSSHDIYEEAEADNEESDKDSLNEMFPSAILNGTG 769

Query: 648 APGNGKPVGSPHVVTSHQSKVTVESTPDLEKQP---------NENGVSVQNENFEEIINL 698
           +P   K   +     +H+     + T  + K+P         N    S+++ + +E+++ 
Sbjct: 770 SPTKFKMPFNNAKKMTHKLVFLEDGTSQVRKEPKTYFNGDLKNFRQKSMKDTSIQEVVSR 829

Query: 699 PIG-------SKPSRLDVTNSES 714
           P         +K  + D TN+ S
Sbjct: 830 PSSKRMTSHTTKTRKADETNTTS 852


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 56/143 (39%), Positives = 91/143 (63%), Gaps = 6/143 (4%)

Query: 477 EEATRLLAEKRRLAREQREKE---ERERREQEELERQKREE-LAQRVAEERTTRREEESR 532
           E   +L  E+RR  +E+RE++   E+E R ++ L+RQ+ EE L QR+  E+  RRE+E R
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545

Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQER-EKHFQR 591
           R E    RE+E++L+++  E+ L+  +E  R Q  K EE R ++  +R ++ER E+  +R
Sbjct: 546 R-EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604

Query: 592 EEQERLERKKRLEEIMKRTRRTE 614
           EE ERLE+++R E+ +KR    E
Sbjct: 605 EEVERLEQEERREQRLKREEPEE 627



 Score = 86.7 bits (213), Expect = 7e-17
 Identities = 60/142 (42%), Positives = 88/142 (61%), Gaps = 11/142 (7%)

Query: 482  LLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRRL--EA 536
            L  E+ +L RE+REK   +ERER+ +EE E Q+ EE  Q + EER TRR +E  R   + 
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEE--QLLGEERETRRRQELERQYRKE 1083

Query: 537  EQAREKEEQLQRQAEE---RALREREEAERAQRQKEEEARVREEAE-RVRQEREKHFQRE 592
            E+ +++EEQL R+  E   R  RER+  E  + Q+EEE  +REE E R RQE E+ ++ E
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143

Query: 593  EQERLERKKRLEEIMKRTRRTE 614
            E+ + E ++ L E  ++ RR E
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQE 1165



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 58/168 (34%), Positives = 94/168 (55%), Gaps = 14/168 (8%)

Query: 477 EEATRLLAEKRRLAREQREKEERER-----REQEEL-ERQKREELAQRVAEERTTRREEE 530
           EE  R   E+RR  +E+RE++E  R     REQEE  E+Q R E  +   E++  R +EE
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370

Query: 531 SRR---LEAEQAREKEEQLQRQAE---ERALREREEAERAQRQKEEEARVREEAERVRQE 584
            RR   L  EQ   +E+QL+R+ +   E+ LR  ++  R Q+ + E+   RE+  R  QE
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430

Query: 585 REKHFQREEQERLERKKRLEEIMKR--TRRTEATDKKTSDQRNGDIAK 630
            E+H Q+ EQER E++ + E+  +R   +R E T++   ++R   + +
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478



 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 56/141 (39%), Positives = 86/141 (60%), Gaps = 12/141 (8%)

Query: 482  LLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQ 538
            L  E+ +L RE+ EK   +ERER+ +EE E Q+ EE   R   E+  R+E E +  E E+
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145

Query: 539  AREKEEQLQRQAEERALREREEAERAQR-----QKEEEARVREEAERVRQEREKHFQREE 593
             +++EEQL R+  E+  R R+E ER  R     Q+EEE  +REE E+ RQERE+ ++  E
Sbjct: 1146 VQQEEEQLLREEPEK--RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR--E 1201

Query: 594  QERLERKKRLEEIMKRTRRTE 614
            +E L+R+KR +      +R++
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSD 1222



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 62/159 (38%), Positives = 90/159 (56%), Gaps = 19/159 (11%)

Query: 475  DPEEATRLLAEKR-------RLAREQREKEERERREQEELERQKREELAQRVAEERTTRR 527
            +PE+  R   EK+       +   EQ  +EERE+R ++E ERQ R++   +  EE+  R 
Sbjct: 977  EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036

Query: 528  EEESRRL-EAEQAREKEEQLQRQ-----AEERALREREEAERAQR-----QKEEEARVRE 576
            E E RRL E E+   +EE+LQ++      EER  R R+E ER  R     Q+EEE  +RE
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096

Query: 577  EAE-RVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
            E E R RQERE+  + EE+ + E ++ L E  ++ RR E
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE 1135



 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 57/146 (39%), Positives = 88/146 (60%), Gaps = 11/146 (7%)

Query: 478  EATRLLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
            E  +L  E+ +L RE+REK   +ERER+ +++ + Q++EE       E+  R+E E +  
Sbjct: 932  EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991

Query: 535  EAEQAREKEEQLQRQAEERALREREEAERAQRQK-----EEEARVREEAERVR-QEREKH 588
            E E+ +++EEQL R  EER  R R+E ER  R+K     EEE  +REE E+ R QERE+ 
Sbjct: 992  EEEELQQEEEQLLR--EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049

Query: 589  FQREEQERLERKKRLEEIMKRTRRTE 614
            ++ EE+ + E ++ L E  +  RR E
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQE 1075



 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 52/147 (35%), Positives = 87/147 (59%), Gaps = 7/147 (4%)

Query: 485 EKRRLAREQ--REKEERERREQEELERQKREELAQR-VAEERTTRREEESRR---LEAEQ 538
           +++RL REQ  R K+E ERREQ+E  R+++E   Q+    E+  RRE+E RR   L  EQ
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355

Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ-EREKHFQREEQERL 597
             E+ EQ  R+ +E   RE++     Q ++E++ R  ++  R +Q  RE+  +RE+Q R 
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415

Query: 598 ERKKRLEEIMKRTRRTEATDKKTSDQR 624
           E++ R E+ ++R +  E  ++K   +R
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQER 442



 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 68/182 (37%), Positives = 93/182 (51%), Gaps = 33/182 (18%)

Query: 477  EEATRLLAEKRRLAREQREK---------EERERREQEELERQKREELAQRVAEERTTRR 527
            E   R L E+ R  RE+ E          EERE R ++ELERQ R+E   +  EE+  R 
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096

Query: 528  EEESRR--------LEAEQAREKEEQLQRQAEERALREREEAERAQR-----QKEEEARV 574
            E E RR         E E+ +++EEQL R  EER  R R+E ER  R     Q+EEE  +
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLR--EEREKRRRQELERQYREEEEVQQEEEQLL 1154

Query: 575  REEAE-RVRQEREKHFQREEQ--------ERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
            REE E R RQE E+ ++ EE+         R E++KR +E  ++ R  E   ++   QR 
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214

Query: 626  GD 627
             D
Sbjct: 1215 RD 1216



 Score = 83.2 bits (204), Expect = 8e-16
 Identities = 55/166 (33%), Positives = 99/166 (59%), Gaps = 19/166 (11%)

Query: 477 EEATRL---LAEKRRLAREQREKEER--ERREQEELERQKREELAQRVAEER---TTRRE 528
           EE  RL   L  +++L REQ E+ E+  +R E++ LE+++RE+  +R  EER     +RE
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582

Query: 529 EESR--RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE--EAERVRQE 584
           EE R  RL+ EQ    E++L+R+  ER  +E    +R +R++ EE R ++  ++E   + 
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642

Query: 585 REKHFQREEQERLERK-------KRLEEIMKRTRRTEATDKKTSDQ 623
           R++  +RE+QER E++       +RLE+ +KR    E  +++ +++
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 55/158 (34%), Positives = 95/158 (60%), Gaps = 10/158 (6%)

Query: 477 EEATRLLAEKRRLAREQREKEERERR-EQEEL--ERQKREELAQRVAEERTTRR-EEESR 532
           +E  +L  E+ +  RE +E+EE+ R+ E++EL  ERQ+ E+  QR+  E+  RR +EE R
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314

Query: 533 RLEAEQAREKEEQLQRQAEERAL---REREEAERAQRQKEEEARVREEAERVRQE---RE 586
           R + E+ RE++E+ ++Q E R     RE+EE    Q ++E+E   RE+  R  QE   RE
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374

Query: 587 KHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           +  +RE+Q R E++ R E+ ++R ++     +   +Q+
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 56/159 (35%), Positives = 93/159 (58%), Gaps = 21/159 (13%)

Query: 486 KRRLAREQREK-------EERERREQE----ELERQKREELAQR----VAEERTTRREEE 530
           ++RL REQ E+       EE ER EQE    +L+R + EE  +R      EER  ++E  
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503

Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEAR----VREEAERVRQE-R 585
            ++L  EQ   +E++L+RQ EE  L++R  +E+  R+++EE R     REE +R+ QE R
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563

Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           E+  +RE++ER ++  + EE  +R +R +   ++  +QR
Sbjct: 564 EQRLKREQEERRDQLLKREE-ERRQQRLKREQEERLEQR 601



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 59/158 (37%), Positives = 86/158 (54%), Gaps = 30/158 (18%)

Query: 485  EKRRLAREQRE--------KEERERRE---------QEELER-----QKREELAQRVAEE 522
            ++RR ++EQR         +EER+RR          QE+L +     Q+ EE  QR   E
Sbjct: 860  QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919

Query: 523  RTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQR------QKEEEARVRE 576
            +  R+E+E +  E EQ +++EEQL R  EER  R R+E ER  R      QKEE+    E
Sbjct: 920  KRRRQEQERQYREEEQLQQEEEQLLR--EEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977

Query: 577  EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
              +R RQEREK ++ EE+ + E ++ L E  ++ RR E
Sbjct: 978  PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 48/154 (31%), Positives = 87/154 (56%), Gaps = 6/154 (3%)

Query: 476  PEEATRLLAEKRRLAREQRE--KEERERREQEELERQKREELAQRVAEERTTRREEESRR 533
            P    +L  E++ L  E+ E  +EERE+R ++E ERQ REE   +  EE+  R E E RR
Sbjct: 893  PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952

Query: 534  LEAEQAREKEEQLQRQAEERALRE----REEAERAQRQKEEEARVREEAERVRQEREKHF 589
             +  + + ++++  +Q EE+ L E    R   ER ++ +EEE   +EE + +R+EREK  
Sbjct: 953  RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012

Query: 590  QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
            ++E + +  +K  L++  ++  R E   ++  ++
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046



 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 44/135 (32%), Positives = 82/135 (60%), Gaps = 7/135 (5%)

Query: 477  EEATRLLAEKRRLAREQR------EKEERERREQEELERQKREELAQRVAEERTTRREEE 530
            EE  R   E+ +L R++R      E++ R  RE+++L RQ+R+   +   + R  R E++
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ 1787

Query: 531  SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
             R  E+++   +EEQL+++ EE+ LR ++  +   R +EE+ ++ E+ +R+RQER++ ++
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQR-DGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846

Query: 591  REEQERLERKKRLEE 605
             EEQ   + K R EE
Sbjct: 1847 AEEQFATQEKSRREE 1861



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 49/161 (30%), Positives = 91/161 (56%), Gaps = 11/161 (6%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           +P+    L  E+ +L + +R++  RER+E+E+ +++ R E   R  +E   R ++E RR 
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323

Query: 535 EAEQAREKEE----QLQRQAEERA----LREREEAERAQ---RQKEEEARVREEAERVRQ 583
           + E+  ++EE    QL+R+ EER      RE+EE  R Q   R++EEE R ++     + 
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383

Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            RE+  +RE+Q R E++ R E+ ++R ++     +   +Q+
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 424



 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 55/160 (34%), Positives = 91/160 (56%), Gaps = 17/160 (10%)

Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
           PEE  +   E+RR  R +REKE +   E+E+L+R++R   AQ++ EE    +E++ RR  
Sbjct: 812 PEEEEK---EQRRRQRREREKELQFLEEEEQLQRRER---AQQLQEEEDGLQEDQERRRS 865

Query: 536 AEQAREKEEQLQRQAEER----------ALREREEAERAQRQKEEEARVREEAE-RVRQE 584
            EQ R+++ + Q + E +          AL+E+   E+   Q+EEE   REE E R RQE
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925

Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           +E+ ++ EEQ + E ++ L E  ++ RR E   +   D++
Sbjct: 926 QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 54/163 (33%), Positives = 94/163 (57%), Gaps = 22/163 (13%)

Query: 481 RLLAEKRRLAREQREKEERERR-----EQEELERQKREELA----QRVAEERTTRR---- 527
           R L E RR  RE+++++ RER+     E+EE E +KRE +     +++ EE   R+    
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272

Query: 528 --EEESRRLEAEQAR----EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERV 581
             EE+ R+LE ++ R    E+E+Q QR   E+ LR ++E ER ++Q EE    +E  E+ 
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ-EERREQQERREQQ 331

Query: 582 RQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            + RE+  +RE++ER E++ R E+  +  RR +   ++  ++R
Sbjct: 332 EERREQQLRREQEERREQQLRREQ--EEERREQQLRREQEEER 372



 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 47/142 (33%), Positives = 85/142 (59%), Gaps = 6/142 (4%)

Query: 485  EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
            E+++L RE+RE+   +RR QE   + + EE   +  EE+  RR+E  R+   E+ R +E+
Sbjct: 1316 EEKQLLREEREE---KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372

Query: 545  QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE--RLERKKR 602
              +   EE+ LR R+E ER   ++E++ R +E  +++RQ+R++ F+ EEQ+  R ER ++
Sbjct: 1373 GRKFLEEEQRLR-RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431

Query: 603  LEEIMKRTRRTEATDKKTSDQR 624
              E  ++ RR E   K   +++
Sbjct: 1432 FREEEQQVRRQERERKFLEEEQ 1453



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 45/148 (30%), Positives = 91/148 (61%), Gaps = 9/148 (6%)

Query: 483 LAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
           L  +++L REQ+ + E++ R +++L R+++    Q++  E+  RRE+E  R E +  +E+
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442

Query: 543 EEQ-LQRQAEERA--LREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
            EQ L+R+ EER   L+  EE ER ++++ ++   R++ E   + RE+  + EE+ER E+
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE---ERRERWLKLEEEERREQ 499

Query: 600 KKRLEEIMKR---TRRTEATDKKTSDQR 624
           ++R E+ ++R    RR +   ++  ++R
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEER 527



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 54/151 (35%), Positives = 95/151 (62%), Gaps = 15/151 (9%)

Query: 483 LAEKRRLAREQR-EKEERERREQEELERQKREELAQRVAEERTT--RREEESRRLEAEQA 539
           L  +++L REQ+  +E+ E R +++ E+++RE+  +R  EER    +REEE+ R E E+ 
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER- 471

Query: 540 REKEEQLQRQAEERALRER----EEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
             +++QL+R  EE   RER    EE ER ++Q+  E ++R E E  R++R K  ++EE+E
Sbjct: 472 --RKQQLKRDQEEER-RERWLKLEEEERREQQERREQQLRREQEERREQRLK--RQEEEE 526

Query: 596 RLERKKRLEEIMKRTR--RTEATDKKTSDQR 624
           RL+++ R E+ ++R +  R E   K+  ++R
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEKR 557



 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 51/158 (32%), Positives = 90/158 (56%), Gaps = 12/158 (7%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           EE T    ++RR  + +R++EE  R    +LE ++R E  +R   E+  RRE+E RR + 
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER--REQQLRREQEERREQR 518

Query: 537 EQAREKEEQLQRQ--AEERALREREEAERAQRQKEEEARVREEAERVRQEREKH------ 588
            + +E+EE+LQ++  +E++  RE+EE      ++EEE R+ +E    R +RE+       
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578

Query: 589 FQREEQERLERKKRLEE--IMKRTRRTEATDKKTSDQR 624
            +REE+ R +R KR +E  + +R +R E    +  ++R
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616



 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 65/172 (37%), Positives = 100/172 (58%), Gaps = 34/172 (19%)

Query: 483 LAEKRRLAREQRE-----KEERERREQ----EELERQ---KREELAQRVAEER----TTR 526
           L  +++L REQ E     K E+ERREQ    E+ ER+   KREE  +R  +ER      R
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478

Query: 527 REEESRR-----LEAEQARE----KEEQLQRQAEER---ALREREEAERAQRQKEEEARV 574
            +EE RR     LE E+ RE    +E+QL+R+ EER    L+ +EE ER Q++   E ++
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538

Query: 575 REEAERVRQEREKHFQREEQERLERKKRLEEIMKRTR--RTEATDKKTSDQR 624
           R E E   + RE+  +REE++RLE+++R E+ +KR +  R +   K+  ++R
Sbjct: 539 RREQE---ERREQLLKREEEKRLEQERR-EQRLKREQEERRDQLLKREEERR 586



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 59/158 (37%), Positives = 81/158 (51%), Gaps = 29/158 (18%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQ----EELERQKREELAQRVAEERTTR--REEE 530
           EE  RL  E+RR  R +RE+ E ERR+Q    EE E +++++L +   E R  R  REEE
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664

Query: 531 SRRLEAEQAREKEEQLQRQ--AEERALRERE-------------EAERAQRQ-------- 567
             RLE    RE EE+ + Q  AEE   + RE             E+E   RQ        
Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724

Query: 568 KEEEARVREEAERVRQEREKHFQREEQERLERKKRLEE 605
           K+E  R R+E E  R+ RE   Q +E+ER  R+++ EE
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 56/164 (34%), Positives = 88/164 (53%), Gaps = 17/164 (10%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQE-----ELERQKREELAQRVAEERTTRREEES 531
           E+  R   E+ R  ++ R ++E ERREQ+     +L R+++    Q++  E+  RRE++ 
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407

Query: 532 RR---LEAEQAREKEEQLQR-QAEERALREREEAERAQRQKEEEARVR------EEAERV 581
           RR   L  EQ   +E+QL+R Q EER  ++ E+  R QR K E+   R      EE ER 
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467

Query: 582 RQEREKHFQR--EEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
            QER K   +  +E+ER ER  +LEE  +R ++     +   +Q
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 51/154 (33%), Positives = 88/154 (57%), Gaps = 8/154 (5%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR--- 533
           ++  R   E+RR  + +RE+EE  R +Q   E+Q R E  Q++  E+  RRE++ RR   
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE--QQLRREQQLRREQQLRREQQ 406

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ--EREKHFQR 591
           L  EQ   +E+QL+R+ + R  +E E  E+   Q+  E R++ E E  R   +RE+  +R
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466

Query: 592 EEQERLERK-KRLEEIMKRTRRTEATDKKTSDQR 624
            EQER +++ KR +E  +R R  +  +++  +Q+
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 46/157 (29%), Positives = 87/157 (55%), Gaps = 8/157 (5%)

Query: 475  DPEEATRLLAEKRRLAREQREKEERER--REQEELERQKREELAQRVAEERTTRREEESR 532
            + ++  R   E++ L  EQ+ ++ER R  RE+E+L +++ E+   R   +R    EE+  
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494

Query: 533  RLEAEQAREKEEQLQRQAEERA-LREREEAERAQRQK-----EEEARVREEAERVRQERE 586
            R +    + +E++L+ Q  ER  L E ++  R QRQ+     E++ R +E  ++ RQ+R+
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554

Query: 587  KHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
            + F+ EEQ R ER+++     +R R+    ++K   Q
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 52/159 (32%), Positives = 92/159 (57%), Gaps = 13/159 (8%)

Query: 477  EEATRLLAEKRRLAREQREKE-----ERERREQEELERQKREELAQRVAEERTTRREEES 531
            E   + L E+ +L R++RE++     +R+ RE+E+L ++  E+  +R   +R  R EE+ 
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699

Query: 532  RRLEAEQAR--EKEEQLQRQAEERALRE----REEAERAQRQKEEEARVREEAERVRQER 585
             R +  + +  ++E+QL+RQ  ER  RE    R+E E+ Q +++E  R   E E++R ER
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759

Query: 586  EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            E+  Q   QER +RK R EE +++ R  +    + SD++
Sbjct: 1760 EEQ-QLRRQER-DRKFREEEQLRQEREEQQLRSQESDRK 1796



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 46/149 (30%), Positives = 90/149 (60%), Gaps = 9/149 (6%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
            E+  + L E++RL R++RE+  +  +E+++L  Q+RE+  ++  + +    E++  R E 
Sbjct: 1371 EQGRKFLEEEQRLRRQERER--KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428

Query: 537  EQA-REKEEQLQRQAEERALRE-----REEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
            ++  RE+E+Q++RQ  ER   E     R+E  R  R++E+  + REE +  RQER++ F 
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488

Query: 591  REEQERLERKKRLEEIMKRTRRTEATDKK 619
             EEQ+ L R++R  +  ++  R++  ++K
Sbjct: 1489 EEEQQ-LRRQERDRKFREQELRSQEPERK 1516



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 54/168 (32%), Positives = 88/168 (52%), Gaps = 17/168 (10%)

Query: 477 EEATRLLAEKR--RLAREQRE------KEERERREQEELERQKREELAQRVAEERTTRRE 528
           EE  RL  E+R  RL REQ E      K E ERR Q+ L+R++ E L QR+  E   R E
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERR-QQRLKREQEERLEQRLKREEVERLE 611

Query: 529 EESR---RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE-----R 580
           +E R   RL+ E+  E+  Q   ++EE+  R +++  R Q+++ E+   REE E     R
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671

Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDI 628
           +++E E+  + +E    E+++  E I  R  + +   +  +D R   +
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 55/161 (34%), Positives = 90/161 (55%), Gaps = 21/161 (13%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
            EE  +L  E+ R  RE  E++  + RE+++L RQ+R+   + + EE+  RR+E  R+   
Sbjct: 1450 EEEQQLRQERHRKFRE--EEQLLQEREEQQLHRQERDR--KFLEEEQQLRRQERDRKFRE 1505

Query: 537  EQAR---------EKEEQLQRQAEERALREREE----AERAQRQKEEEARVREEAERVRQ 583
            ++ R         E+E+QL RQ  +R   + E+     ER Q+++++  R   E E++RQ
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565

Query: 584  EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            ERE+  Q   QER +RK RLEE  ++ RR E   K   D++
Sbjct: 1566 EREEQ-QLSRQER-DRKFRLEE--QKVRRQEQERKFMEDEQ 1602



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 52/161 (32%), Positives = 90/161 (55%), Gaps = 19/161 (11%)

Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
           P+E      E   L R+ RE+++++RRE+++   Q+ EE   R  E  T  R+EE +  E
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE--TVLRKEEEKLQE 262

Query: 536 AEQAR-----EKEEQLQRQAEERALREREEAERAQ----------RQKEEEARVREEAER 580
            E  R     E+EEQL++   +   RER+E E+ Q          R++EEE R ++E  R
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322

Query: 581 VRQER--EKHFQREEQERLERKKRLEEIMKRTRRTEATDKK 619
            +QER  ++  +RE+Q R E+++R E+ ++R +  E  +++
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 54/163 (33%), Positives = 88/163 (53%), Gaps = 16/163 (9%)

Query: 477  EEATRLLAEKRRLAREQREK---EERERREQEELERQKREE--LAQRVAEERTTRREEES 531
            E   +   E+++L R++RE+   +E ++  ++ELER+ REE  L Q   +E+  R+E   
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747

Query: 532  RRLEAEQAR--EKEEQLQRQAEERALRE----REEAERAQRQKEEEARVREEAERVRQER 585
            + LE EQ R   +E+QL+RQ  +R  RE    R+E E  Q + +E  R   E E++RQER
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807

Query: 586  EKHFQREEQER-----LERKKRLEEIMKRTRRTEATDKKTSDQ 623
            E+   R +Q        E + +LEE  +R R+      +  +Q
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 51/161 (31%), Positives = 83/161 (51%), Gaps = 18/161 (11%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEE----RTTRREEESR 532
            E+  R     R+   E+   +E+ R+  EE +R +R+E  ++  +E    R   RE++ R
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR 1409

Query: 533  RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
            +    + RE+E+QL RQ  +R  RE E+  R Q   E E +  EE +++RQER + F+ E
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ---ERERKFLEEEQQLRQERHRKFREE 1466

Query: 593  EQ----------ERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
            EQ           R ER ++  E  ++ RR E  D+K  +Q
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQE-RDRKFREQ 1506



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 61/208 (29%)

Query: 477  EEATRLLAEKRRLAREQRE--KEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
            +E  R   E+  + +E+ +  +EE E+R ++ELERQ REE   +  EE+  R E+E RR 
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193

Query: 535  EAEQAREKEEQLQRQ------------------------------------AEERALRER 558
            E E+   +EE+LQRQ                                     E    R+ 
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253

Query: 559  EEAERAQRQK---------EEEARVREEAERVRQEREKHFQREEQ----ERLERKKR--- 602
            E+++   RQ          E++ R RE+  R  Q+R++HF  EEQ    E+ E K+R   
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313

Query: 603  -------LEEIMKRTRRTEATDKKTSDQ 623
                   L E  +  RR + TD+K  ++
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREE 1341



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 49/151 (32%), Positives = 88/151 (58%), Gaps = 14/151 (9%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
            EE      E+++L R++R+++ RE  E+++L RQ+R        E +  + E++ RR E 
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFRE--EEQQLRRQER--------ERKFLQEEQQLRRQEL 1721

Query: 537  EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE--- 593
            E+   +EEQL+++ E+  LR R+E  R   ++E+    REE +  RQER++ F+ EE   
Sbjct: 1722 ERKFREEEQLRQETEQEQLR-RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR 1780

Query: 594  QERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            QER E++ R +E  ++ R  E   ++  +Q+
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 46/134 (34%), Positives = 79/134 (58%), Gaps = 8/134 (5%)

Query: 487  RRLAREQREKEERER--REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR--EK 542
            RR  R Q+ +++R+R  RE+E+L +++ E+   R   +R  R EE+  R + ++ +  E 
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600

Query: 543  EEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE--RLERK 600
            E+QL+RQ  ++ LR+  E +R  R+ E+  + REE +  RQER++ F  EE +  R ER+
Sbjct: 1601 EQQLRRQEGQQQLRQ--ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658

Query: 601  KRLEEIMKRTRRTE 614
            ++L     R  R E
Sbjct: 1659 QQLRHDRDRKFREE 1672



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 51/152 (33%), Positives = 87/152 (57%), Gaps = 14/152 (9%)

Query: 477  EEATRLLAEKRRLAREQR-----EKEERERREQEELERQKRE---ELAQRVAEERTTRRE 528
            +E  R   + ++L +++      E E+R R+E+E+  R++ E   E  Q + EER  RR 
Sbjct: 954  QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013

Query: 529  EE---SRRLEAEQAREKEEQLQRQAEERALREREE--AERAQRQKEEEARVREEAE-RVR 582
            +E     R + E  +E+E+ L+ + E+R L+ERE    E  + Q+EEE  + EE E R R
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073

Query: 583  QEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
            QE E+ +++EE+ + E ++ L E  ++ RR E
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)

Query: 477  EEATRLLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRR 533
            EE  R   E+++L R++R++   EE + R++ E ++ + +E  ++  EE   R+E E ++
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811

Query: 534  LEAEQA----REKEEQLQRQAEERALR-EREEAERAQRQKEEEARVREEAERVRQEREKH 588
            L  +Q     R +EEQLQ + +E+ LR ER+   RA+ Q   + + R E + + QE E+ 
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871

Query: 589  FQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNG 626
             +R+E+ER  R++ +    K  +R     +  S +  G
Sbjct: 1872 -RRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 47/160 (29%), Positives = 91/160 (56%), Gaps = 28/160 (17%)

Query: 477  EEATRLLAEKRRLAREQ-----REKEERERREQEELERQKREELAQR-------VAEERT 524
            E+  + + ++++L R++     R++ +R+ RE E+L +++ E+   R       + EE  
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651

Query: 525  TRREEESRRLEAEQARE--KEEQLQRQAEERALRE-------REEAERAQRQKEEEARVR 575
             RR+E  ++L  ++ R+  +EEQL ++ EE+ LR        REE ++ +RQ+ E   ++
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711

Query: 576  EEAERVRQEREKHFQRE-------EQERLERKKRLEEIMK 608
            EE +  RQE E+ F+ E       EQE+L R++R  +I++
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 54/186 (29%), Positives = 91/186 (48%), Gaps = 38/186 (20%)

Query: 477 EEATRLLAEKRRLAREQREKEERER-REQEELERQKRE--ELAQRVAEERTTRR------ 527
           +E  R LAE    + +Q   E+R+R R  EEL RQ++E  E  +R AEE   +       
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201

Query: 528 -----EEESRRLEA----EQAREKEEQLQRQAEERALREREEAERAQRQ----KEEEARV 574
                EE+ RR E      + RE+++Q +R+ ++R  +E EE E  +R+    KEEE   
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261

Query: 575 REEAERVRQ----------------EREKHFQREEQERLERKKRLEEIMKRTRRTEATDK 618
            EE +R R+                 RE+  + ++Q+RL R+++L    +  RR +  ++
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321

Query: 619 KTSDQR 624
           +   +R
Sbjct: 322 REQQER 327



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 17/164 (10%)

Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQ----------RVAEERTTRR 527
           E  +L + K     E  ++E+  RRE  EL R+ REE  Q          +  EE+  R+
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248

Query: 528 EEESRRLEAEQAREKEEQLQR--QAEERALREREEAE-RAQRQKEEEARV---REEAERV 581
            E   R E E+ +E+E Q QR  Q EE  LR+ E  E R +RQ+EE+ +    RE+  R 
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308

Query: 582 RQEREKHFQREE-QERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           +QE E+  Q+EE +E+ ER+++ EE  ++  R E  +++    R
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 46/150 (30%), Positives = 84/150 (56%), Gaps = 23/150 (15%)

Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTR-----------REEESRRL 534
           +RR +  Q ++EER  R+Q+E E Q+R+   Q  AEE++ R           RE+  R+L
Sbjct: 740 RRRESELQWQEEERAHRQQQE-EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQR----QKEEEARVREEAERVRQEREKHFQ 590
            AE+ +++E++   + EE+  R R+  ER +     ++EE+ + RE A+++++E +   +
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858

Query: 591 REEQERLERKKR-------LEEIMKRTRRT 613
            +E+ R + ++R       LEE  KR R T
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHT 888



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 49/163 (30%), Positives = 87/163 (53%), Gaps = 27/163 (16%)

Query: 477  EEATRLLAEKRRLAREQREKEERERR------------EQEELERQKR------EELAQR 518
            E   + L E+++L R++R+++ RE+             E+++L RQ+R      EE   R
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541

Query: 519  VAEERTTRREEESRRL-EAEQAREK--EEQLQRQAEERALR------EREEAERAQRQKE 569
              E    RR++  R+  E EQ R++  E+QL RQ  +R  R       R+E ER   + E
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601

Query: 570  EEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRR 612
            ++ R +E  +++RQER++ F+ +EQ   ER+++     +R R+
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 48/139 (34%), Positives = 78/139 (56%), Gaps = 15/139 (10%)

Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTR--REEESRR-----LEA 536
           A + ++    R++E + RR+++E +R++RE   Q   EER  R  +EEE RR      +A
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773

Query: 537 EQAREKEEQL------QRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
           E+  E+  Q        R+  ER LR  E  +R QR   EE   +E+  R R+EREK  Q
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE-KEQRRRQRREREKELQ 832

Query: 591 -REEQERLERKKRLEEIMK 608
             EE+E+L+R++R +++ +
Sbjct: 833 FLEEEEQLQRRERAQQLQE 851



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 56/179 (31%), Positives = 96/179 (53%), Gaps = 41/179 (22%)

Query: 477  EEATRLLAEKRRLAREQREK-----------EERERREQEELERQKREELAQRVAEERTT 525
            EE  R   E+++L+R++R++           +E+ER+  E+ ++ +R+E  Q++ +ER  
Sbjct: 1560 EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619

Query: 526  R-REEESRRLEAEQAR-----------EKEEQLQRQAEERALRE------REEAERAQ-- 565
            + RE+E    E E+ +           E+E QL+RQ  E+ LR       REE +  Q  
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679

Query: 566  -----RQKEEEARVREEAERV-RQEREKHFQREEQ----ERLERKKRLEEIMKRTRRTE 614
                 R++E + + REE +++ RQERE+ F +EEQ    + LERK R EE +++    E
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 50/180 (27%), Positives = 89/180 (49%), Gaps = 40/180 (22%)

Query: 485 EKRRLAREQREKE----ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQ-- 538
           ++RR  R+++E+E    E +  +QE LE++ R+   + +  +R   +E E RR E EQ  
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194

Query: 539 ---------------------------AREKEEQLQRQAEERALREREEAERAQRQ---- 567
                                       RE+++Q +R+ ++R  +E EE E  +R+    
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254

Query: 568 KEEEARVREEAERVR--QEREKHFQREEQERLERKKRLEE-IMKRTRRTEATDKKTSDQR 624
           KEEE    EE +R R  QE E+  ++ E++ L R+++ EE   +R RR +   +K  ++R
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 30/169 (17%)

Query: 485  EKRRLAREQREKEE---RERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQARE 541
            ++RR  R+++ +EE   R+ RE+++L RQ+R+    R+ E++  R+E+E + +E EQ   
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF-RLEEQKVRRQEQERKFMEDEQQLR 1605

Query: 542  KEEQLQRQAEER---------ALREREE-----AERAQRQKEEEARVR--EEAERVRQER 585
            ++E  Q+  +ER          L+EREE      ER ++  EEE ++R  E  +++R +R
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665

Query: 586  EKHFQREEQ----------ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            ++ F+ EEQ           R ER ++  E  ++ RR E   K   +++
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 40/130 (30%), Positives = 71/130 (54%), Gaps = 5/130 (3%)

Query: 495  EKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERA 554
            E++ER+R    E ER++ ++  +   EE    REE+      ++  ++E+QL R+  E  
Sbjct: 1273 EQQERDR----EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328

Query: 555  LREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
             R R+E +R  R++E+  + REE    RQER++ F+ EE    E+ ++  E  +R RR E
Sbjct: 1329 -RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE 1387

Query: 615  ATDKKTSDQR 624
               K   +++
Sbjct: 1388 RERKFLKEEQ 1397



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 48/166 (28%), Positives = 91/166 (54%), Gaps = 25/166 (15%)

Query: 477  EEATRLLAEKRRLAREQRE----KEERERREQEELERQKREELAQRVAEERTTRREEESR 532
            +E  R   E+ +L +E+ E    ++ER+R+  EE ++ +R+E  ++  E+    +E E +
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516

Query: 533  RLEAEQAR----------EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR 582
             LE EQ            ++E+QL+RQ  ER  + R++ +R  R++E+  + REE +  R
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQ--ERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574

Query: 583  QEREKHFQ-------REEQER--LERKKRLEEIMKRTRRTEATDKK 619
            QER++ F+       R+EQER  +E +++L     + +  +  D+K
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 47/166 (28%), Positives = 86/166 (51%), Gaps = 22/166 (13%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQE--ELERQKREELAQRVAEERTTRREEESRRL 534
            EE      E+ R  RE+ ++  R+ RE++  E E+Q R+E  ++  EE    +E E ++L
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478

Query: 535  EAEQAR----EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
              ++      E+E+QL+RQ  +R  RE+E     + Q+ E   + EE +  RQ+R++ F 
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQE----LRSQEPERKFLEEEQQLHRQQRQRKFL 1534

Query: 591  REEQ------------ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            +EEQ            +  +RK R EE +++ R  +   ++  D++
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 52/157 (33%), Positives = 79/157 (50%), Gaps = 22/157 (14%)

Query: 483 LAEKRRLAREQREKEERERREQEE---LERQKREELAQRVAEERTTRREEESRRLEAEQA 539
           L + RR   +QR  E R+R+ +EE     RQKR+E  + +AE     + E+  RLE    
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE--EQSEKQERLEQRDR 166

Query: 540 REKEEQLQRQAEERALREREEAERAQRQK-----------EEEARVREEAERVRQEREKH 588
           + ++E+L RQ +E   RE   AE  Q Q            EE+ R RE  E  R+ RE+ 
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE- 225

Query: 589 FQREEQERLERKKRL--EEIMKRTRRTEATDKKTSDQ 623
              ++Q+R ER+ R+  EE  K  R+ E   +K  ++
Sbjct: 226 ---KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 54/190 (28%), Positives = 90/190 (47%), Gaps = 42/190 (22%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQE---ELERQKREELAQRVAE------------ 521
           E+  +   E+ RL +  + + E ERREQE   E + Q RE +  R+ +            
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715

Query: 522 -----ERTTRREEESRRLEAEQAREKEE-QLQRQAEERALREREEAERAQ--------RQ 567
                 R  ++E + RR E E+ R + E +LQ Q EERA R+++E E+ +         +
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775

Query: 568 KEEEAR--------VREEAERV-----RQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
           K E  R        +RE+ ER      RQ+RE+ F  EE+E+ +R+++  E  K  +  E
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835

Query: 615 ATDKKTSDQR 624
             ++    +R
Sbjct: 836 EEEQLQRRER 845



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)

Query: 61  LRVDDRQRLARERREEREKQLAAREIVWLER--EERARQHYEKHLEERKKRLEEQRQKEE 118
           LR  +RQ L RER+EE ++Q   R    L R  EE  R+  E+  E++++R +++ ++E+
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337

Query: 119 RRRAAVEEKRRQRL--EEDKERHEAVVRRTMERSQKPKQ 155
           + R   EE+R Q+L  E+++ER E  +RR  E  ++ +Q
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 44/115 (38%), Positives = 64/115 (55%), Gaps = 8/115 (6%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQEELERQK---REELAQRVAEERTTRREEESRR 533
            EE  R   E+++L  +QR+ + R   EQ +LE Q+   R+E  ++   E     +E+SRR
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859

Query: 534  LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKH 588
             E E  +E EEQ +RQ  ER LRE    E  +RQ++EE R R+  E   QE + H
Sbjct: 1860 EEQELWQE-EEQKRRQERERKLRE----EHIRRQQKEEQRHRQVGEIKSQEGKGH 1909



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 37/98 (37%), Positives = 60/98 (61%), Gaps = 8/98 (8%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHY--EKHLEERKKRLEEQRQKEERR--- 120
           +QRL RE+ E  E++L   E+  LE+EER  Q    E+  EER+++L +  ++EERR   
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646

Query: 121 -RAAVEEKRRQRL--EEDKERHEAVVRRTMERSQKPKQ 155
            R   +E+R QRL  EE++ER E  ++R  E  ++ ++
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 16/153 (10%)

Query: 478 EATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESR 532
           +AT L  EKR     + +  Q  ++E ++R  E  +RQ  EE  QR    R  R+E+E  
Sbjct: 91  QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR---RRQKRQEQERE 147

Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
             E E+  EK+E+L+++  +R    R+E    QRQ+ +E   R   E   Q  + H   E
Sbjct: 148 LAEGEEQSEKQERLEQRDRQR----RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE 203

Query: 593 --EQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
             ++E+L R++ LE  ++R  R E   ++   Q
Sbjct: 204 FPDEEQLRRRELLE--LRRKGREEKQQQRRERQ 234



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 41/112 (36%), Positives = 66/112 (58%), Gaps = 15/112 (13%)

Query: 60  VLRVDDRQRLARERREER-EKQLAAREIVWLEREERARQH-----YEKHLEERKKRLEEQ 113
           +L+ ++ +RL +ERRE+R +++   R    L+REE  RQ       E+ LE+R KR E +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608

Query: 114 R-QKEERR-----RAAVEEKRRQRL---EEDKERHEAVVRRTMERSQKPKQK 156
           R ++EERR     R   EE+RRQ+L   EE +ER +  +RR  +  ++ + K
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 33/104 (31%), Positives = 59/104 (56%), Gaps = 4/104 (3%)

Query: 60  VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ--RQKE 117
           VLR ++ +    E + +RE Q    ++  LER+E  R+  E+  ++++ R E+Q  R++E
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311

Query: 118 ERRRAAVEEKRRQ--RLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           E RR   EE+R Q  R E+ +ER E  +RR  E  ++ + +  +
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 28/96 (29%), Positives = 53/96 (55%), Gaps = 2/96 (2%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           Q+L RE++  RE+QL   + +  E++ R  Q   +  EE +   + ++++ E+R    +E
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452

Query: 127 KRRQRL--EEDKERHEAVVRRTMERSQKPKQKHNRW 160
           +RR  L  EE+ ERHE   R+   +  + +++  RW
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 36/116 (31%), Positives = 59/116 (50%), Gaps = 7/116 (6%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           Q+  +ERRE+R K+       WL+REE      E+H +ER+K+  ++ Q+EERR   ++ 
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEET----ERHEQERRKQQLKRDQEEERRERWLKL 491

Query: 127 KRRQRLEEDKERHEAVVRRTME--RSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
           +  +R  E +ER E  +RR  E  R Q+ K++         L     +     +RR
Sbjct: 492 EEEER-REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 28/101 (27%), Positives = 58/101 (57%), Gaps = 14/101 (13%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           +Q+L R++ EER ++       WL+ EE  R+  ++  E++ +R +E+R+++  +R   E
Sbjct: 473 KQQLKRDQEEERRER-------WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525

Query: 126 EKRRQRL-------EEDKERHEAVVRRTMERSQKPKQKHNR 159
           E+ +QRL        E +ER E +++R  E+  + +++  R
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 31/95 (32%), Positives = 54/95 (56%), Gaps = 11/95 (11%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERRR 121
           ++ + L RE RE+R +Q   R+     REE   Q  E+ L  EER+KR  ++R+++ R+ 
Sbjct: 908 EEEEELQREEREKRRRQEQERQY----REEEQLQQEEEQLLREEREKRRRQERERQYRKD 963

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             +++K  Q L E+ E+     RR  ER +K +++
Sbjct: 964 KKLQQKEEQLLGEEPEK-----RRRQEREKKYREE 993



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 29/86 (33%), Positives = 55/86 (63%), Gaps = 3/86 (3%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREER-ARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           +QRL RE++  R+++   RE     RE++  R+  E+  E++ +R +E+R++++ RR   
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356

Query: 125 EEKRRQRL--EEDKERHEAVVRRTME 148
           EE+R Q+L  E+++ER E  +RR  +
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQ 382



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 33/97 (34%), Positives = 54/97 (55%), Gaps = 9/97 (9%)

Query: 67  QRLARER-REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           QRL RE   EER +QL   E     R+++ R+  ++  E+R KR EE+ + E+R +   E
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
           E+RR++   ++E+ +A   R   +S+ PK     W W
Sbjct: 678 EERREQELAEEEQEQA---RERIKSRIPK-----WQW 706



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 33/105 (31%), Positives = 55/105 (52%), Gaps = 16/105 (15%)

Query: 58  PPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKE 117
           PP+    +RQ  A ER++  ++ L   E    E+E+R RQ  E+  E+  + LEE+ Q +
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEE----EKEQRRRQRRER--EKELQFLEEEEQLQ 841

Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
            R RA   ++    L+ED+ER     RR+ E     +++  +W W
Sbjct: 842 RRERAQQLQEEEDGLQEDQER-----RRSQE-----QRRDQKWRW 876



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 34/102 (33%), Positives = 55/102 (53%), Gaps = 9/102 (8%)

Query: 64   DDRQRLARER--REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
            + R+R  RER  REE E Q    +++  ERE+R RQ  E+   E +   E Q+++E+  R
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE---EVQQEEEQLLR 1155

Query: 122  AAVEEKRRQRLE----EDKERHEAVVRRTMERSQKPKQKHNR 159
               E++RRQ LE    E++E  +   +   E  +K +Q+  R
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 30/99 (30%), Positives = 54/99 (54%), Gaps = 6/99 (6%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ-----KEERR 120
            RQ   R+ REE E Q    +++  ERE+R RQ  E+   E ++  +E+ Q      E+RR
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162

Query: 121  RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            R  +E + R+  EE ++  E ++R   E+ ++ +++  R
Sbjct: 1163 RQELERQYREE-EELQQEEEQLLREEQEKRRQERERQYR 1200



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 6/105 (5%)

Query: 61  LRVDDRQRLARERREEREKQL-AAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEE 118
           LR   R+   ++RRE +++      E  W +RE   R+  EK  EE  +R  E Q ++E+
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ 277

Query: 119 RRRAAVEEKRRQRLEEDKE----RHEAVVRRTMERSQKPKQKHNR 159
            R+   +E RR+R EE+++    R E  +RR  E  ++ +Q+  R
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 27/97 (27%), Positives = 55/97 (56%), Gaps = 2/97 (2%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE-RRRAAVE 125
           Q+L RE+ EER +Q   RE   L RE++ R+  +   E++ +R ++ R++++ RR   + 
Sbjct: 362 QQLRREQEEERREQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
            +++ R E+++ERHE    +     +  +++  R  W
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 32/97 (32%), Positives = 53/97 (54%), Gaps = 7/97 (7%)

Query: 66  RQRLARERREER---EKQLAAREIVWLEREE----RARQHYEKHLEERKKRLEEQRQKEE 118
           RQR  +E  E+    E+Q   RE    E+++    R +Q   K  EER+++ EE+R+++E
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
           RR    E + +Q   E +ER E  +RR  E  ++ +Q
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 31/99 (31%), Positives = 55/99 (55%), Gaps = 8/99 (8%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           R  + +R  R +R+E E++L  R    L  E++ R+  E+  E+  KR EE+R ++ERR 
Sbjct: 509 REQEERREQRLKRQEEEERLQQR----LRSEQQLRREQEERREQLLKREEEKRLEQERRE 564

Query: 122 AAV----EEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             +    EE+R Q L+ ++ER +  ++R  E   + + K
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 28/80 (35%), Positives = 50/80 (62%), Gaps = 2/80 (2%)

Query: 71  RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR-LEEQRQKEERRRAAVEEKRR 129
           RE++EER +Q   RE     RE++ R+  E+  E++ +R  EE+R++++ RR   EE+R 
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374

Query: 130 QRLEEDKE-RHEAVVRRTME 148
           Q+L  +++ R E  +RR  +
Sbjct: 375 QQLRREQQLRREQQLRREQQ 394



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 28/93 (30%), Positives = 52/93 (55%), Gaps = 1/93 (1%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           Q+L RE+ EER +Q   RE     RE++ R+  +   E++ +R ++ R++++ RR     
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           + +Q   E + R E  +RR  E  ++ +QKH +
Sbjct: 409 REQQLRREQQLRREQQLRREQE-EERHEQKHEQ 440



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 31/89 (34%), Positives = 50/89 (56%), Gaps = 8/89 (8%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHY--EKHLEERKKRLEEQRQKEERRRAAV 124
           Q+L RE+ E RE++L  +E      EER +Q    E+ L   ++   EQ  K E  +   
Sbjct: 505 QQLRREQEERREQRLKRQE-----EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559

Query: 125 EEKRRQRLE-EDKERHEAVVRRTMERSQK 152
           +E+R QRL+ E +ER + +++R  ER Q+
Sbjct: 560 QERREQRLKREQEERRDQLLKREEERRQQ 588



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 31/100 (31%), Positives = 56/100 (56%), Gaps = 11/100 (11%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV-- 124
           Q+L RE+ EER +Q   +E     RE+R ++  E+  +  K+  E +R ++ERR+  +  
Sbjct: 423 QQLRREQEEERHEQKHEQE----RREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478

Query: 125 --EEKRRQR---LEEDKERHEAVVRRTMERSQKPKQKHNR 159
             EE+RR+R   LEE++ R +   R    R ++ +++  R
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 31/100 (31%), Positives = 54/100 (54%), Gaps = 9/100 (9%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLE---REERARQHYEKHLEERKKRLEEQRQ--- 115
           R+   Q+L RE+ E RE+ L   E   LE   RE+R ++  E+  ++  KR EE+RQ   
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRL 590

Query: 116 ---KEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
              +EER    ++ +  +RLE+++ R + + R   E  ++
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 2/94 (2%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           R  L RE   ER +Q   ++ +  ++EE  R+ + K  EE ++  +E+R+++ RR    E
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ--E 512

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           E+R QRL+  +E      R   E+  + +Q+  R
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 33/102 (32%), Positives = 54/102 (52%), Gaps = 9/102 (8%)

Query: 64   DDRQRLARERREEREKQLAARE--IVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
            + R+R  +ER+   E+QL   E  ++  ERE+R RQ  E+   + KK     +QKEE+  
Sbjct: 919  EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK----LQQKEEQLL 974

Query: 122  AAVEEKRRQRLEEDKERHEAVVRRTME---RSQKPKQKHNRW 160
                EKRR++  E K R E  +++  E   R ++ K++   W
Sbjct: 975  GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 11/109 (10%)

Query: 65   DRQRLARERREER-----EKQLAAREIVWLEREERARQHYEK----HLEERKKRLEEQRQ 115
            + ++L RE RE+R     E+Q    E V  E E+  R+  EK     LE + +  EE +Q
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178

Query: 116  KEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHN--RWSW 162
            +EE+     +EKRRQ  E      E + R+  ++  + + + +  +W W
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 30/98 (30%), Positives = 53/98 (54%), Gaps = 6/98 (6%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ----KEERRR 121
            RQ   R+ REE + Q    +++  ERE+R RQ  E+   + KK  +++ Q    + E+RR
Sbjct: 923  RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982

Query: 122  AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
                EK+ +  EE ++  E ++R   ER ++ +Q+  R
Sbjct: 983  RQEREKKYREEEELQQEEEQLLRE--EREKRRRQEWER 1018



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/105 (29%), Positives = 57/105 (54%), Gaps = 11/105 (10%)

Query: 66  RQRLARERREEREKQLAAREIVW------LEREERARQHYEKHLEERKKRLEEQ-----R 114
           R+R  R  +EE EK+   RE V       L+ EE  RQ   +  EE+ ++LE Q     R
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290

Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           Q+EE+++  +  +++ R ++++ER E    R  ++ ++ +Q+  R
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 3/94 (3%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
            RQ L R+ R+E E Q    +++  E E+R RQ  E+   E +   E Q+++E+  R   E
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE---ELQQEEEQLLREERE 1129

Query: 126  EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            ++RRQ LE      E V +   +  ++  +K  R
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 34/99 (34%), Positives = 52/99 (52%), Gaps = 3/99 (3%)

Query: 64   DDRQRLARERREEREKQLAAREIVWLER--EERARQHYEKHLEERKKRLEEQRQKEERRR 121
            +++Q L  ER E+R +Q   R+    E+  +ER  Q   +   +RK R EE R +E+ R+
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375

Query: 122  AAVEEKRRQRLE-EDKERHEAVVRRTMERSQKPKQKHNR 159
               EE+R +R E E K   E    R  ER Q+ +Q  +R
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 10/100 (10%)

Query: 67   QRLARERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQ--------RQK 116
            Q   R+ REE E Q    +++  ERE R RQ  E+    EE  ++ EEQ        R++
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103

Query: 117  EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            +ER R   EE+  Q+ EE   R E   RR  E  ++ +++
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 29/98 (29%), Positives = 54/98 (55%), Gaps = 6/98 (6%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ----RQKEERRR 121
            RQ   ++ REE E Q    +++  ERE+R RQ +E+   ++ +  +E+    R++ E+RR
Sbjct: 983  RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042

Query: 122  AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              ++E+ RQ  EE++ + E       ER  + +Q+  R
Sbjct: 1043 --LQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 40/129 (31%), Positives = 64/129 (49%), Gaps = 30/129 (23%)

Query: 64   DDRQRLARERREER----EKQLAAREIVWLEREE------------RARQHYEKHLEE-- 105
            ++ Q+L R+ RE +    E+QL  +E+    REE            R ++ Y K LEE  
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754

Query: 106  -RKKRLEEQRQKEER-RRAAVEEKRRQRLEED---------KERHEAVVRRTMERSQ-KP 153
             R +R E+Q +++ER R+   EE+ RQ  EE          K R E  +R+  E  Q +P
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814

Query: 154  KQKHNRWSW 162
            +Q+  ++ W
Sbjct: 1815 QQRDGKYRW 1823



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)

Query: 65  DRQRLARERREEREKQLAARE-IVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           ++Q   RE++E RE+Q   RE  +  E+EER  Q   +  EE ++  + +R++EE RR  
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375

Query: 124 VEEKRRQRLEEDKERHEAVVRRTME 148
              + +Q   E + R E  +RR  +
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQ 400



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 27/102 (26%), Positives = 56/102 (54%), Gaps = 8/102 (7%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           R++  R  +EER +Q   RE     RE++ R+  E+   E++ R E+Q ++E++ R   +
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394

Query: 126 EKRRQRLEEDKE-RHEAVVRRTME-------RSQKPKQKHNR 159
            +R Q+L  +++ R E  +RR  +       R ++ +++H +
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 30/97 (30%), Positives = 55/97 (56%), Gaps = 5/97 (5%)

Query: 65   DRQRLARERREEREKQLAAREIVWLEREERARQH-YEKHLEERKKRL----EEQRQKEER 119
            +RQ    E+ ++ E+QL   E     R+ER RQ+  +K L++++++L     E+R+++ER
Sbjct: 927  ERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER 986

Query: 120  RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             +   EE+  Q+ EE   R E   RR  E  ++ ++K
Sbjct: 987  EKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 25/102 (24%), Positives = 55/102 (53%), Gaps = 9/102 (8%)

Query: 55   PDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQR 114
            P+   + R + ++   R+R+ + EKQL   E      E+R RQ  ++   E ++ L+E+ 
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREE----REEKRRRQETDRKFREEEQLLQERE 1349

Query: 115  QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            ++  RR     ++R ++  E++ RH+   R+ +E  Q+ +++
Sbjct: 1350 EQPLRR-----QERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 29/94 (30%), Positives = 51/94 (54%), Gaps = 3/94 (3%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           R+R  +   EER +Q   RE   L RE+  R+      +E ++RL+++ + E++ R   E
Sbjct: 485 RERWLKLEEEERREQQERRE-QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE 543

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           E+R Q L+ ++E+     RR  E+  K +Q+  R
Sbjct: 544 ERREQLLKREEEKRLEQERR--EQRLKREQEERR 575



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 30/96 (31%), Positives = 58/96 (60%), Gaps = 7/96 (7%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           +QRL  E++  RE++    ++  L+REE  R   E+  E+R KR +E+R+ +  +R   E
Sbjct: 529 QQRLRSEQQLRREQEERREQL--LKREEEKRLEQERR-EQRLKREQEERRDQLLKRE--E 583

Query: 126 EKRRQRLEEDKER--HEAVVRRTMERSQKPKQKHNR 159
           E+R+QRL+ ++E    + + R  +ER ++ +++  R
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 31/99 (31%), Positives = 57/99 (57%), Gaps = 8/99 (8%)

Query: 63   VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ--RQKEERR 120
            +++ Q+L R++R+ +  Q    E   L R+ER +Q  +    +RK R EEQ  +++EE++
Sbjct: 1518 LEEEQQLHRQQRQRKFLQ----EEQQLRRQERGQQRRQDR--DRKFREEEQLRQEREEQQ 1571

Query: 121  RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
             +  E  R+ RLEE K R +   R+ ME  Q+ +++  +
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ 1610



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 30/95 (31%), Positives = 51/95 (53%), Gaps = 4/95 (4%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE--RRR 121
           + ++RL +  R+ R+++L  +   W EREER  +  E+ L+  K    E+   EE  RRR
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAE--EEQLQSCKGHETEEFPDEEQLRRR 213

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             +E +R+ R E+ ++R E   R   E  +K  +K
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 20/109 (18%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ------------- 113
           QRL RE  EER +Q  A E      +E+AR+  +  + + + +LE +             
Sbjct: 670 QRLKREHEEERREQELAEE-----EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724

Query: 114 RQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
           +Q+ +RRR   EEKRR+R  E + + E    R  ++ ++ +++   W W
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHR--QQQEEEQRRDFTWQW 771



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 28/110 (25%), Positives = 56/110 (50%), Gaps = 17/110 (15%)

Query: 64   DDRQRLARERREEREKQLAARE--IVWLEREERARQHYEKHL---------------EER 106
            + R+R  RER+  ++K+L  +E  ++  E E+R RQ  EK                 EER
Sbjct: 949  EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008

Query: 107  KKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            +KR  ++ +++ R++  ++++  Q L E++E+     R    R ++  Q+
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 5/91 (5%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
            R+   + RR+ERE+Q    E +  E E+  R+  EK     ++R E +RQ  E      E
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREK-----RRRQELERQYREEEEVQQE 1149

Query: 126  EKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            E++  R E +K R + + R+  E  +  +++
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEE 1180



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 4/100 (4%)

Query: 64   DDRQRLARERREEREKQLAARE--IVWLEREERARQHYEKHL--EERKKRLEEQRQKEER 119
            + R+   RER+   E++L   E  ++  ERE R RQ  E+    EE  ++ EEQ  +EE 
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098

Query: 120  RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
             +   +E+ RQ  EE++ + E       ER ++ +Q+  R
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 30/103 (29%), Positives = 56/103 (54%), Gaps = 14/103 (13%)

Query: 64   DDRQRLARERR------EEREKQLAAREIVWLEREERARQHYEKHLEER----KKRLEEQ 113
            ++ Q+L+R+ R      EE++ +   RE  +LE E++ RQ   +   E     ++R E+Q
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477

Query: 114  RQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
              ++ER R  +EE+++ R +E     +   R    RSQ+P++K
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQE----RDRKFREQELRSQEPERK 1516



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 26/96 (27%), Positives = 53/96 (55%), Gaps = 5/96 (5%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ--RQKEERRRAA 123
            RQ   ++RR++R+++    E +   R+ER  Q   +   +RK RLEEQ  R++E+ R+  
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQL---RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598

Query: 124  VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
             +E++ +R E  ++  +   R+  E  Q  +++  +
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 39/107 (36%), Positives = 61/107 (57%), Gaps = 13/107 (12%)

Query: 65   DRQRLARE---RREEREKQLAA-REIVWLEREERARQHYEKHLE----ERKKRLEEQR-Q 115
            DR+ L  E   RR+ERE+QL   R+  + E E+  ++  E+ L     +RK R EEQ+ +
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701

Query: 116  KEERRRAAVEEK---RRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            ++ER R  ++E+   RRQ LE  K R E  +R+  E+ Q  +Q+  R
Sbjct: 1702 RQERERKFLQEEQQLRRQELER-KFREEEQLRQETEQEQLRRQERYR 1747



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 23/92 (25%), Positives = 54/92 (58%), Gaps = 5/92 (5%)

Query: 65   DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
            + ++L RE RE+R +Q   R+  + +++E  ++  +   EER+KR  ++R+++ R    +
Sbjct: 999  EEEQLLREEREKRRRQEWERQ--YRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056

Query: 125  EEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            +++  Q L E++E      R+ +ER  + +++
Sbjct: 1057 QQEEEQLLGEERETRR---RQELERQYRKEEE 1085



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 26/103 (25%), Positives = 51/103 (49%), Gaps = 7/103 (6%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
            +QR  + R EE + QL        E+E+R RQ  ++     ++   +++ + E +    E
Sbjct: 1815 QQRDGKYRWEEEQLQLE-------EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867

Query: 126  EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHG 168
            E++++R E +++  E  +RR  +  Q+ +Q     S  G  HG
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHG 1910



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 29/99 (29%), Positives = 52/99 (52%), Gaps = 5/99 (5%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKH-LEERKK--RLEEQRQKEERRRA 122
            R+   + RR+E E+Q   ++ +  E E+  R+  EK  L+ER++  R EE+ Q+EE +  
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064

Query: 123  AVEE--KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              E   +RRQ LE    + E + +   +  ++  +K  R
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 30/104 (28%), Positives = 54/104 (51%), Gaps = 3/104 (2%)

Query: 56   DPPPVLRVDDRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEE 112
            D   + R + +Q+L +ER     E E+ L  RE   L R+ER R+  E+  + R++  E+
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ 1659

Query: 113  QRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            Q + +  R+   EE+  Q  EE + R +   R+  E  Q+ +++
Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 35/114 (30%), Positives = 59/114 (51%), Gaps = 13/114 (11%)

Query: 59   PVLRVDDRQRLARERRE----EREKQLAAREIVWLEREERARQHYEKHLE------ERKK 108
            P LR  +R++  R  R+    E E+ L   E   L R+ER R+  E+  +      ERK 
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709

Query: 109  RLEEQ--RQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ-KPKQKHNR 159
              EEQ  R++E  R+   EE+ RQ  E+++ R +   R+ +E  Q +P+++  +
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 28/120 (23%), Positives = 57/120 (47%), Gaps = 13/120 (10%)

Query: 515 LAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARV 574
           L Q    +   R   + +    +  R++E+Q + +  +R L E     R Q+++E+E  +
Sbjct: 89  LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148

Query: 575 REEAERVRQEREKHFQREEQERLE---RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKG 631
            E  E          Q E+QERLE   R++R EE+ ++ +  +  +++ +++      KG
Sbjct: 149 AEGEE----------QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 21/118 (17%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           +Q L  E +EER +Q   RE      +   R+  E+ LE+R KR  E+ ++E+      +
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690

Query: 126 EKRRQR-----------LEEDKERHEAVV----------RRTMERSQKPKQKHNRWSW 162
           E+ R+R           LE + +  ++ V          RR  E+ +K +++ +   W
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 7/86 (8%)

Query: 70  ARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRR 129
           A + +  +E+QL   E   L+REER ++  ++  +ER+ R EEQ Q+EE +    E ++R
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQE--QERQYREEEQLQQEEEQLLREEREKR 951

Query: 130 QRLEEDKERHEAVVRRTMERSQKPKQ 155
           +R E +++      R+  +  QK +Q
Sbjct: 952 RRQERERQ-----YRKDKKLQQKEEQ 972



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 8/101 (7%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHL--------EERKKRLEEQRQKE 117
            RQ L R+ REE E Q    +++  E E+R RQ  E+          EE +   EEQ ++ 
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192

Query: 118  ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHN 158
            + R     E+   + ++ K+R+    +R+  + Q   +K N
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 32/111 (28%), Positives = 62/111 (55%), Gaps = 11/111 (9%)

Query: 60   VLRVDDRQRLARERRE----EREKQLAA--REIVWLEREERARQHYEKHLEERKKRLEEQ 113
            +L+  + Q+L R+ R+    E E+QL    R+  + E+E R+++   K LEE ++   +Q
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528

Query: 114  RQK----EERRRAAVEEKRRQRLEEDKE-RHEAVVRRTMERSQKPKQKHNR 159
            RQ+    EE++    E  +++R + D++ R E  +R+  E  Q  +Q+ +R
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDR 1579



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 24/123 (19%)

Query: 61   LRVDDRQRLARE----RREEREKQLAAREI-VWLEREERARQHYEK-------------- 101
            LR  +R R  RE    R+E  E+QL ++E       EE+ RQ  E+              
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW 1823

Query: 102  -----HLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
                  LEE+++RL ++R ++ R       + + R EE +   E   +R  ER +K +++
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREE 1883

Query: 157  HNR 159
            H R
Sbjct: 1884 HIR 1886



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 28/104 (26%), Positives = 52/104 (50%), Gaps = 10/104 (9%)

Query: 66  RQRLARERREEREKQLAAR--EIVWLEREERARQHYEKHLE-------ERKKRLEEQRQK 116
           R++  + RR+E+E++   R  E+ W E E   RQ  E+          + +++ E  RQ+
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783

Query: 117 EERRRAAVEEKRRQ-RLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              R    E++ RQ R EE ++R +  +    E+ Q+ +Q+  R
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/107 (33%), Positives = 62/107 (57%), Gaps = 15/107 (14%)

Query: 60   VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE------ERKKRLEEQ 113
            +L+  + Q+L   RR+ER+++    E   L R+ER R+  ++  +      ERK R EEQ
Sbjct: 1675 LLQEGEEQQL---RRQERDRKFREEE-QQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730

Query: 114  -RQKEERRRAAVEEKRRQRLEEDK---ERHEAVVRRTMERSQKPKQK 156
             RQ+ E+ +   +E+ R+ LEE++   ER E  +RR  ER +K +++
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR-QERDRKFREE 1776



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 25/95 (26%), Positives = 52/95 (54%), Gaps = 5/95 (5%)

Query: 62   RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
            +++D Q   R+ +++ +  L  ++    E+E R  Q  ++H  E +++LE + QKE +RR
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE-EEQLEREEQKEAKRR 1310

Query: 122  AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
                ++ +Q L E++E      RR  E  +K +++
Sbjct: 1311 DRKSQEEKQLLREEREEK----RRRQETDRKFREE 1341



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 21/84 (25%), Positives = 44/84 (52%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           ++Q    ++ E RE+QL   +    E++ R  Q  E+  ++ ++  EE+R++++ RR   
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 125 EEKRRQRLEEDKERHEAVVRRTME 148
             + +Q   E + R E  +RR  +
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQ 406



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 13/102 (12%)

Query: 71  RERREEREKQLAAREIVW---LEREERARQH-------YEKHLEERKKRL---EEQRQKE 117
           +E +E R  Q   R+  W   LE E + R+H        ++ L + ++ L   EE+ Q+E
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916

Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           ER +   +E+ RQ  EE++ + E       ER ++ +Q+  R
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 28/95 (29%), Positives = 51/95 (53%), Gaps = 4/95 (4%)

Query: 65   DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
            DR++  R R ++R++     E   LEREE+          + +K+L  + ++E+RRR   
Sbjct: 1278 DREQ-ERRRWQQRDRHFPEEE--QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334

Query: 125  EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            + K R+  +  +ER E  +RR  ER +K +++  R
Sbjct: 1335 DRKFREEEQLLQEREEQPLRR-QERDRKFREEELR 1368



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 28/97 (28%), Positives = 49/97 (50%), Gaps = 9/97 (9%)

Query: 71  RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
           R++R+E+E++LA  E    E++ER  Q   +  +E   R  ++ Q+ E RRA  E+ +  
Sbjct: 138 RQKRQEQERELAEGE-EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC 196

Query: 131 RLEEDKE--------RHEAVVRRTMERSQKPKQKHNR 159
           +  E +E        R E +  R   R +K +Q+  R
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 4/89 (4%)

Query: 72  ERREEREKQLAAREIVW--LEREERARQHYEKHL--EERKKRLEEQRQKEERRRAAVEEK 127
           E R+ R   L A+  +   L +E++  Q  E+ L  EER+KR  ++++++ R    ++++
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939

Query: 128 RRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             Q L E++E+     R    R  K  Q+
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQ 968



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 24/66 (36%), Positives = 35/66 (53%), Gaps = 3/66 (4%)

Query: 65   DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
            DRQ  A E+   +EK     + +W E E++ RQ  E+ L E   R   ++QKEE+R   V
Sbjct: 1842 DRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIR---RQQKEEQRHRQV 1898

Query: 125  EEKRRQ 130
             E + Q
Sbjct: 1899 GEIKSQ 1904



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 28/115 (24%), Positives = 63/115 (54%), Gaps = 19/115 (16%)

Query: 64  DDRQRLARERREEREKQLA-AREIVWLEREERARQHYEKH---LEERKKRLEEQRQKEER 119
           ++ +   R +R EREK+L    E   L+R ERA+Q  E+     E++++R  ++++++++
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873

Query: 120 RRAAVEEKRRQR---------LEEDKERHEAVVR------RTMERSQKPKQKHNR 159
            R  +EE+R++R         L+E   + + +++      +  ER ++ +Q+  R
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 27/97 (27%), Positives = 52/97 (53%), Gaps = 5/97 (5%)

Query: 65   DRQRLARERREEREKQLAAREIVWLEREERARQH-YEKHLEERKKRL----EEQRQKEER 119
            +RQ   ++  ++ E+QL   E      +ER RQ+  E+ L++ +++L     E R+++E 
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076

Query: 120  RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             R   +E+  Q+ EE   R E   RR  ER ++ +++
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 30/109 (27%), Positives = 56/109 (51%), Gaps = 10/109 (9%)

Query: 61   LRVDDRQRLARER--REEREKQLAAREIVWLEREERAR----QHYEKHLEERKKRLEEQR 114
            LR  +R R  RE   R + + +    E   L R+ER R    +  +   +ER+++L + R
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412

Query: 115  ----QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
                ++EE++ +  E  R+ R EE + R +   R+ +E  Q+ +Q+ +R
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 8/105 (7%)

Query: 61   LRVDDRQRLARERRE----EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK 116
            LR  +R++  R+ R+    E E+QL+ +E     REE   Q   +   ERK   EEQ+ +
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE--EQQVRRQERERKFLEEEQQLR 1456

Query: 117  EERRRAAVEEKR--RQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            +ER R   EE++  ++R E+   R E   +   E  Q  +Q+ +R
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 24/96 (25%), Positives = 51/96 (53%), Gaps = 3/96 (3%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           D+ Q   RE  E R K    RE    +R ER  + +++  E+  ++ E   +KEE +   
Sbjct: 206 DEEQLRRRELLELRRK---GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            E +R++ L+E++E+   + R+ + R ++ +++  +
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 26/101 (25%), Positives = 55/101 (54%), Gaps = 13/101 (12%)

Query: 64   DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQR--QKEERRR 121
            D + R   +  +ERE+Q   R+    ER+ + R+   +H E+ +K LEE++  +++ER R
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQ----ERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390

Query: 122  AAVEE-------KRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
              ++E       +R Q+L +D++R      + + R ++ ++
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 18/112 (16%)

Query: 63   VDDRQRLARERRE-------------EREKQLAAREIVWLEREERARQHYEKHLEERKKR 109
            +++ QRL R+ RE             ERE+QL          EE+     E+   +RK R
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER---DRKFR 1433

Query: 110  LEEQR-QKEERRRAAVEEKRRQRLEEDKE-RHEAVVRRTMERSQKPKQKHNR 159
             EEQ+ +++ER R  +EE+++ R E  ++ R E  + +  E  Q  +Q+ +R
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 22/95 (23%), Positives = 53/95 (55%), Gaps = 6/95 (6%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREER-ARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           + +   + RR+ RE++   +E+ +LE EE+  R+   + L+E +  L+E +++   +   
Sbjct: 813 EEEEKEQRRRQRRERE---KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869

Query: 124 VEEKRRQRLEEDKE--RHEAVVRRTMERSQKPKQK 156
            ++K R +LEE+++  RH    +  ++   + +Q+
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ 904



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 24/91 (26%), Positives = 45/91 (49%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           R D + R   E   +R +     +    E+  + +Q  ++  EE ++   E+R+++E+ R
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
              EE++ Q+ EE   R E   RR  ER ++
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQ 959



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 28/101 (27%), Positives = 52/101 (51%), Gaps = 8/101 (7%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLERE-----ERARQHYEKHLEERKKRLEEQRQK 116
           R D ++ L ++RR+E +++        LE E      + RQ  E+ L E +++ E+Q + 
Sbjct: 102 RCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERL 161

Query: 117 EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKH 157
           E+R R   +E+  ++ +E +ER E   RR  E   +  + H
Sbjct: 162 EQRDRQRRDEELWRQRQEWQEREE---RRAEEEQLQSCKGH 199



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 28/116 (24%)

Query: 63   VDDRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
            +++ Q+L +ER     E E+ L  RE   L R+ER R    K LEE     E+Q +++ER
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR----KFLEE-----EQQLRRQER 1499

Query: 120  RRAAVE------EKRRQRLEEDKERH----------EAVVRRTMERSQKPKQKHNR 159
             R   E      E  R+ LEE+++ H          E    R  ER Q+ +Q  +R
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 24/89 (26%), Positives = 47/89 (52%), Gaps = 6/89 (6%)

Query: 73  RREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER---RRAAVEE--- 126
           +R ER +QL   E    E +ER R   ++  ++ + +LEE+R++       + A++E   
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
           K +Q L+E++E  +   R    R ++ +Q
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQ 929



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 23/90 (25%), Positives = 45/90 (50%), Gaps = 3/90 (3%)

Query: 63   VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
            + + Q+L R+ R ++ +Q   R+      EE+ RQ  E+    R++R  + R +E++ R 
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKF---REEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590

Query: 123  AVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
              +E++    E+   R E   +   ER +K
Sbjct: 1591 QEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 33/111 (29%), Positives = 57/111 (51%), Gaps = 19/111 (17%)

Query: 65   DRQRLARERRE----EREKQLAAREIVWLEREERARQHYEKH--LEERKKRLEEQRQKEE 118
            + Q++ R+ +E    E E+QL  +E     R+ER R+  E    L+ER+   E+Q  ++E
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE---EQQLHRQE 1640

Query: 119  RRRAAVEE-------KRRQRLEEDKE---RHEAVVRRTMERSQKPKQKHNR 159
            R R  +EE       +R Q+L  D++   R E  + +  E  Q  +Q+ +R
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 21/70 (30%), Positives = 42/70 (60%), Gaps = 2/70 (2%)

Query: 89  LEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE--KRRQRLEEDKERHEAVVRRT 146
           L+ E+RAR   ++ L + +++ E+QR+ E R R   EE  +RR++  +++ER  A     
Sbjct: 95  LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154

Query: 147 MERSQKPKQK 156
            E+ ++ +Q+
Sbjct: 155 SEKQERLEQR 164



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 28/120 (23%), Positives = 58/120 (48%), Gaps = 23/120 (19%)

Query: 62  RVDDRQRLARER--REER--------------------EKQLAAREIVWLEREERARQHY 99
           R ++  R  +E   REER                    E+QL  RE++ L R+ R  +  
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228

Query: 100 EKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           ++  E + +  +E+ +KE R+R  V  K  ++L+E++ + +  ++   E+ +K +++  R
Sbjct: 229 QRR-ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 25/79 (31%), Positives = 44/79 (55%), Gaps = 12/79 (15%)

Query: 64   DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
            +  QRL    R+ER++Q  A E  +  +E+  R+  E   EE +KR    RQ+ ER+   
Sbjct: 1832 EQEQRL----RQERDRQYRAEE-QFATQEKSRREEQELWQEEEQKR----RQERERK--- 1879

Query: 124  VEEKRRQRLEEDKERHEAV 142
            + E+  +R +++++RH  V
Sbjct: 1880 LREEHIRRQQKEEQRHRQV 1898



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 17/55 (30%), Positives = 29/55 (52%)

Query: 74   REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKR 128
            REE+EK+   RE  + E EE  RQ  ++   +  +R + + Q E  +  AV + +
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 20/61 (32%), Positives = 35/61 (57%), Gaps = 2/61 (3%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQEE-LERQKREELAQR-VAEERTTRREEESRRL 534
            +E +R   ++     EQ+ ++ERER+ +EE + RQ++EE   R V E ++   +   R L
Sbjct: 1854 QEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL 1913

Query: 535  E 535
            E
Sbjct: 1914 E 1914


>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
           sapiens]
          Length = 1293

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 26/234 (11%)

Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATR----------LLAEK 486
           P   + P PA      +  A ++ +             + EE  R          +L  +
Sbjct: 707 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 766

Query: 487 RRLAREQREKEERERREQEE-LERQKREELA---QRVAEERTTRREE----ESRRLEAEQ 538
           +   R++RE+EE  RR+QEE L RQ+ +E+A   QR  EER  + E     E RR E E+
Sbjct: 767 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 826

Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598
            R++EE L++Q EE A   REE E  +R +E   R+ EEA R+R E E+  ++E    LE
Sbjct: 827 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE----LE 882

Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL----TGGTEVSALPCTTNA 648
            +++ E + +R ++ EA  +    Q+   +A+  L    T G + +   C + A
Sbjct: 883 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQA 936



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 46/163 (28%), Positives = 87/163 (53%), Gaps = 25/163 (15%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVAEERTTRREEESRRLE 535
           EEA R L E+RR   E+R++EE  R+++EE  +  REE  AQR  EE   R EEE+ RL 
Sbjct: 811 EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 870

Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER--------------- 580
            E+   K ++L+ Q ++  +R+R++ + A R+ +++ + ++ A+                
Sbjct: 871 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTT 930

Query: 581 ---------VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
                    + + ++   +RE Q R E++++  E+MK  ++ +
Sbjct: 931 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 973



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 26/87 (29%), Positives = 53/87 (60%), Gaps = 2/87 (2%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           ++ + R ++EE  K+    E+   ++EE  R+  E+ +  R++R EE+RQ++E     +E
Sbjct: 759 QEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 818

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQK 152
           E+RR+  EE++ + E ++R+  E + K
Sbjct: 819 ERRRE--EEERRKQEELLRKQEEEAAK 843



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 24/157 (15%)

Query: 475 DPEEATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
           + EEA R L E R       AR + E+EER+R+   ELE Q+++EL +     +  +++E
Sbjct: 847 EEEEAQRRLEENRLRMEEEAARLRHEEEERKRK---ELEVQRQKELMR-----QRQQQQE 898

Query: 530 ESRRLEAEQAREKEEQLQ--------RQAEERALREREEAERAQRQKEEEAR---VREEA 578
             RRL+ +Q +++  Q++        +Q+   A + +     A+ QK EE R   +REE 
Sbjct: 899 ALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQ 958

Query: 579 ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
            R ++E  K  Q+++Q++ ++      + K +  T++
Sbjct: 959 RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS 995



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 21/109 (19%)

Query: 65  DRQRLARERREE-----REKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQK 116
           + + LAR ++EE     RE+++A R     +REE  RQ  E   + LEER++  EE+R++
Sbjct: 775 EEEELARRKQEEALRRQREQEIALRR----QREEEERQQQEEALRRLEERRREEEERRKQ 830

Query: 117 EERRR---------AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           EE  R         A  EE+ ++RLEE++ R E    R     ++ K+K
Sbjct: 831 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 879



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 27/98 (27%), Positives = 55/98 (56%), Gaps = 11/98 (11%)

Query: 62  RVDDRQRLARERREERE--KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ-----R 114
           R+++R+R   ERR++ E  ++       W   EE A    ++ LEE + R+EE+      
Sbjct: 816 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA----QRRLEENRLRMEEEAARLRH 871

Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
           ++EER+R  +E +R++ L   +++ +  +RR  ++ Q+
Sbjct: 872 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQ 909



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 17/134 (12%)

Query: 19  RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
           RS + PD+  + + +  +S+P     G   +   +   P P L          E+ ++ E
Sbjct: 675 RSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL----------EQLQQLE 724

Query: 79  KQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAVEEKRRQRLEED-- 135
           K  AA+    LE+E R  +   K  EE +KR EE +RQ+EE  R   EE+R++R EE+  
Sbjct: 725 KAKAAK----LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 780

Query: 136 KERHEAVVRRTMER 149
           + + E  +RR  E+
Sbjct: 781 RRKQEEALRRQREQ 794



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 5/93 (5%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           +R   ER+ + E +    EI+  ++EE  ++  E+ L  RK+    +RQ+E+        
Sbjct: 743 KREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---- 798

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            RRQR EE++++ E  +RR  ER ++ +++  +
Sbjct: 799 -RRQREEEERQQQEEALRRLEERRREEEERRKQ 830



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 24/74 (32%), Positives = 41/74 (55%), Gaps = 1/74 (1%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           +  A+  REE E Q    E      EE AR  +E+  E ++K LE QRQKE  R+   ++
Sbjct: 839 EEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEE-ERKRKELEVQRQKELMRQRQQQQ 897

Query: 127 KRRQRLEEDKERHE 140
           +  +RL++ +++ +
Sbjct: 898 EALRRLQQQQQQQQ 911



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 19/56 (33%), Positives = 33/56 (58%)

Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           + LE+ K    EQ ++E   RA  EE+ R+R EE + + E ++RR  E  +K +++
Sbjct: 721 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 40/184 (21%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 386  EKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAP 445
            E+E Q+   E  L+      ++     EER   E EV      M        A       
Sbjct: 848  EEEAQRRLEENRLRMEEEAARLRHEE-EERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 906

Query: 446  APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ----REKEERER 501
                  A +  PSS+     S  T+  +    +AT  LAE ++L  E+    RE++ R++
Sbjct: 907  QQQQQLAQMKLPSSSTWGQQSNTTACQS----QATLSLAEIQKLEEERERQLREEQRRQQ 962

Query: 502  REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561
            RE  +  +Q++++  Q+++      +   + +   E  +E+  Q+Q+Q +++  ++ ++ 
Sbjct: 963  RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ--QQHQQP 1020

Query: 562  ERAQ 565
             RA+
Sbjct: 1021 NRAR 1024



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 34/129 (26%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           R+   +  AR R EE E++   +E+    ++E  RQ  ++  +E  +RL++Q+Q+++  +
Sbjct: 859 RLRMEEEAARLRHEEEERK--RKELEVQRQKELMRQRQQQ--QEALRRLQQQQQQQQLAQ 914

Query: 122 AAV------------------------------EEKRRQRLEEDKERHEAVVRRTMERSQ 151
             +                              EE+ RQ  EE + +   +++   ++ Q
Sbjct: 915 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQ 974

Query: 152 KPKQKHNRW 160
           + +QK + W
Sbjct: 975 QQQQKLSGW 983



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 14/160 (8%)

Query: 355 KAAPAQVRPPSPGNIRPVKR---EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEAT 411
           + + +  RP +P + +  +    E K EP+ +  EK  ++   E SL  + P  + +E  
Sbjct: 366 QTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPS-RGDEMV 424

Query: 412 VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA 471
            + + P          +  P+  ++P     P P P P+P +    +  V A      S 
Sbjct: 425 ADVQQPL---------SQIPSDTASPL-LILPPPVPNPSPTLRPVETPVVGAPGMGSVST 474

Query: 472 GTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK 511
              D E    L  +  ++    ++    + R   +L+  +
Sbjct: 475 EPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHR 514



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 36/155 (23%), Positives = 72/155 (46%), Gaps = 36/155 (23%)

Query: 39   PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQH 98
            P+S+  GQ +N +  +      L + + Q+L     EERE+QL         REE+ RQ 
Sbjct: 918  PSSSTWGQQSNTTACQSQA--TLSLAEIQKL----EEERERQL---------REEQRRQQ 962

Query: 99   YEKHLEERKKRLEEQRQKEERR--------RAAVEEKRRQRLEEDKERHEAVVRRTMERS 150
                  E  K L++Q+Q+++++        + +   K    +++++ R     ++  ++ 
Sbjct: 963  -----RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1017

Query: 151  QKPKQKHN------RWSWGGSLHGSPSIHSADPDR 179
            Q+P +  N        S G S+ G  SI++  P++
Sbjct: 1018 QQPNRARNNTHSNLHTSIGNSVWG--SINTGPPNQ 1050


>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
           sapiens]
          Length = 1320

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 26/234 (11%)

Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATR----------LLAEK 486
           P   + P PA      +  A ++ +             + EE  R          +L  +
Sbjct: 734 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 793

Query: 487 RRLAREQREKEERERREQEE-LERQKREELA---QRVAEERTTRREE----ESRRLEAEQ 538
           +   R++RE+EE  RR+QEE L RQ+ +E+A   QR  EER  + E     E RR E E+
Sbjct: 794 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 853

Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598
            R++EE L++Q EE A   REE E  +R +E   R+ EEA R+R E E+  ++E    LE
Sbjct: 854 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE----LE 909

Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL----TGGTEVSALPCTTNA 648
            +++ E + +R ++ EA  +    Q+   +A+  L    T G + +   C + A
Sbjct: 910 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQA 963



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 46/163 (28%), Positives = 87/163 (53%), Gaps = 25/163 (15%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVAEERTTRREEESRRLE 535
            EEA R L E+RR   E+R++EE  R+++EE  +  REE  AQR  EE   R EEE+ RL 
Sbjct: 838  EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 897

Query: 536  AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER--------------- 580
             E+   K ++L+ Q ++  +R+R++ + A R+ +++ + ++ A+                
Sbjct: 898  HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTT 957

Query: 581  ---------VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
                     + + ++   +RE Q R E++++  E+MK  ++ +
Sbjct: 958  ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 1000



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 26/87 (29%), Positives = 53/87 (60%), Gaps = 2/87 (2%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           ++ + R ++EE  K+    E+   ++EE  R+  E+ +  R++R EE+RQ++E     +E
Sbjct: 786 QEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 845

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQK 152
           E+RR+  EE++ + E ++R+  E + K
Sbjct: 846 ERRRE--EEERRKQEELLRKQEEEAAK 870



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 24/157 (15%)

Query: 475  DPEEATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
            + EEA R L E R       AR + E+EER+R+   ELE Q+++EL +     +  +++E
Sbjct: 874  EEEEAQRRLEENRLRMEEEAARLRHEEEERKRK---ELEVQRQKELMR-----QRQQQQE 925

Query: 530  ESRRLEAEQAREKEEQLQ--------RQAEERALREREEAERAQRQKEEEAR---VREEA 578
              RRL+ +Q +++  Q++        +Q+   A + +     A+ QK EE R   +REE 
Sbjct: 926  ALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQ 985

Query: 579  ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
             R ++E  K  Q+++Q++ ++      + K +  T++
Sbjct: 986  RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS 1022



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 21/109 (19%)

Query: 65  DRQRLARERREE-----REKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQK 116
           + + LAR ++EE     RE+++A R     +REE  RQ  E   + LEER++  EE+R++
Sbjct: 802 EEEELARRKQEEALRRQREQEIALRR----QREEEERQQQEEALRRLEERRREEEERRKQ 857

Query: 117 EERRR---------AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           EE  R         A  EE+ ++RLEE++ R E    R     ++ K+K
Sbjct: 858 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 906



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 27/98 (27%), Positives = 55/98 (56%), Gaps = 11/98 (11%)

Query: 62  RVDDRQRLARERREERE--KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ-----R 114
           R+++R+R   ERR++ E  ++       W   EE A    ++ LEE + R+EE+      
Sbjct: 843 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA----QRRLEENRLRMEEEAARLRH 898

Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
           ++EER+R  +E +R++ L   +++ +  +RR  ++ Q+
Sbjct: 899 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQ 936



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 17/134 (12%)

Query: 19  RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
           RS + PD+  + + +  +S+P     G   +   +   P P L          E+ ++ E
Sbjct: 702 RSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL----------EQLQQLE 751

Query: 79  KQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAVEEKRRQRLEED-- 135
           K  AA+    LE+E R  +   K  EE +KR EE +RQ+EE  R   EE+R++R EE+  
Sbjct: 752 KAKAAK----LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 807

Query: 136 KERHEAVVRRTMER 149
           + + E  +RR  E+
Sbjct: 808 RRKQEEALRRQREQ 821



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 5/93 (5%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           +R   ER+ + E +    EI+  ++EE  ++  E+ L  RK+    +RQ+E+        
Sbjct: 770 KREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---- 825

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            RRQR EE++++ E  +RR  ER ++ +++  +
Sbjct: 826 -RRQREEEERQQQEEALRRLEERRREEEERRKQ 857



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 24/74 (32%), Positives = 41/74 (55%), Gaps = 1/74 (1%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           +  A+  REE E Q    E      EE AR  +E+  E ++K LE QRQKE  R+   ++
Sbjct: 866 EEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEE-ERKRKELEVQRQKELMRQRQQQQ 924

Query: 127 KRRQRLEEDKERHE 140
           +  +RL++ +++ +
Sbjct: 925 EALRRLQQQQQQQQ 938



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 19/56 (33%), Positives = 33/56 (58%)

Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           + LE+ K    EQ ++E   RA  EE+ R+R EE + + E ++RR  E  +K +++
Sbjct: 748 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 40/184 (21%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 386  EKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAP 445
            E+E Q+   E  L+      ++     EER   E EV      M        A       
Sbjct: 875  EEEAQRRLEENRLRMEEEAARLRHEE-EERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 933

Query: 446  APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ----REKEERER 501
                  A +  PSS+     S  T+  +    +AT  LAE ++L  E+    RE++ R++
Sbjct: 934  QQQQQLAQMKLPSSSTWGQQSNTTACQS----QATLSLAEIQKLEEERERQLREEQRRQQ 989

Query: 502  REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561
            RE  +  +Q++++  Q+++      +   + +   E  +E+  Q+Q+Q +++  ++ ++ 
Sbjct: 990  RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ--QQHQQP 1047

Query: 562  ERAQ 565
             RA+
Sbjct: 1048 NRAR 1051



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 34/129 (26%)

Query: 62   RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
            R+   +  AR R EE E++   +E+    ++E  RQ  ++  +E  +RL++Q+Q+++  +
Sbjct: 886  RLRMEEEAARLRHEEEERK--RKELEVQRQKELMRQRQQQ--QEALRRLQQQQQQQQLAQ 941

Query: 122  AAV------------------------------EEKRRQRLEEDKERHEAVVRRTMERSQ 151
              +                              EE+ RQ  EE + +   +++   ++ Q
Sbjct: 942  MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQ 1001

Query: 152  KPKQKHNRW 160
            + +QK + W
Sbjct: 1002 QQQQKLSGW 1010



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 14/160 (8%)

Query: 355 KAAPAQVRPPSPGNIRPVKR---EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEAT 411
           + + +  RP +P + +  +    E K EP+ +  EK  ++   E SL  + P  + +E  
Sbjct: 393 QTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPS-RGDEMV 451

Query: 412 VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA 471
            + + P          +  P+  ++P     P P P P+P +    +  V A      S 
Sbjct: 452 ADVQQPL---------SQIPSDTASPL-LILPPPVPNPSPTLRPVETPVVGAPGMGSVST 501

Query: 472 GTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK 511
              D E    L  +  ++    ++    + R   +L+  +
Sbjct: 502 EPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHR 541



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 36/155 (23%), Positives = 72/155 (46%), Gaps = 36/155 (23%)

Query: 39   PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQH 98
            P+S+  GQ +N +  +      L + + Q+L     EERE+QL         REE+ RQ 
Sbjct: 945  PSSSTWGQQSNTTACQSQA--TLSLAEIQKL----EEERERQL---------REEQRRQQ 989

Query: 99   YEKHLEERKKRLEEQRQKEERR--------RAAVEEKRRQRLEEDKERHEAVVRRTMERS 150
                  E  K L++Q+Q+++++        + +   K    +++++ R     ++  ++ 
Sbjct: 990  -----RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1044

Query: 151  QKPKQKHN------RWSWGGSLHGSPSIHSADPDR 179
            Q+P +  N        S G S+ G  SI++  P++
Sbjct: 1045 QQPNRARNNTHSNLHTSIGNSVWG--SINTGPPNQ 1077


>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 26/234 (11%)

Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATR----------LLAEK 486
           P   + P PA      +  A ++ +             + EE  R          +L  +
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 772

Query: 487 RRLAREQREKEERERREQEE-LERQKREELA---QRVAEERTTRREE----ESRRLEAEQ 538
           +   R++RE+EE  RR+QEE L RQ+ +E+A   QR  EER  + E     E RR E E+
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832

Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598
            R++EE L++Q EE A   REE E  +R +E   R+ EEA R+R E E+  ++E    LE
Sbjct: 833 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE----LE 888

Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL----TGGTEVSALPCTTNA 648
            +++ E + +R ++ EA  +    Q+   +A+  L    T G + +   C + A
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQA 942



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 46/163 (28%), Positives = 87/163 (53%), Gaps = 25/163 (15%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVAEERTTRREEESRRLE 535
           EEA R L E+RR   E+R++EE  R+++EE  +  REE  AQR  EE   R EEE+ RL 
Sbjct: 817 EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 876

Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER--------------- 580
            E+   K ++L+ Q ++  +R+R++ + A R+ +++ + ++ A+                
Sbjct: 877 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTT 936

Query: 581 ---------VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
                    + + ++   +RE Q R E++++  E+MK  ++ +
Sbjct: 937 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 979



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 26/87 (29%), Positives = 53/87 (60%), Gaps = 2/87 (2%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           ++ + R ++EE  K+    E+   ++EE  R+  E+ +  R++R EE+RQ++E     +E
Sbjct: 765 QEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 824

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQK 152
           E+RR+  EE++ + E ++R+  E + K
Sbjct: 825 ERRRE--EEERRKQEELLRKQEEEAAK 849



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 24/157 (15%)

Query: 475  DPEEATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
            + EEA R L E R       AR + E+EER+R+   ELE Q+++EL +     +  +++E
Sbjct: 853  EEEEAQRRLEENRLRMEEEAARLRHEEEERKRK---ELEVQRQKELMR-----QRQQQQE 904

Query: 530  ESRRLEAEQAREKEEQLQ--------RQAEERALREREEAERAQRQKEEEAR---VREEA 578
              RRL+ +Q +++  Q++        +Q+   A + +     A+ QK EE R   +REE 
Sbjct: 905  ALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQ 964

Query: 579  ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
             R ++E  K  Q+++Q++ ++      + K +  T++
Sbjct: 965  RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS 1001



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 21/109 (19%)

Query: 65  DRQRLARERREE-----REKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQK 116
           + + LAR ++EE     RE+++A R     +REE  RQ  E   + LEER++  EE+R++
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRR----QREEEERQQQEEALRRLEERRREEEERRKQ 836

Query: 117 EERRR---------AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           EE  R         A  EE+ ++RLEE++ R E    R     ++ K+K
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 27/98 (27%), Positives = 55/98 (56%), Gaps = 11/98 (11%)

Query: 62  RVDDRQRLARERREERE--KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ-----R 114
           R+++R+R   ERR++ E  ++       W   EE A    ++ LEE + R+EE+      
Sbjct: 822 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA----QRRLEENRLRMEEEAARLRH 877

Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
           ++EER+R  +E +R++ L   +++ +  +RR  ++ Q+
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQ 915



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 17/134 (12%)

Query: 19  RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
           RS + PD+  + + +  +S+P     G   +   +   P P L          E+ ++ E
Sbjct: 681 RSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL----------EQLQQLE 730

Query: 79  KQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAVEEKRRQRLEED-- 135
           K  AA+    LE+E R  +   K  EE +KR EE +RQ+EE  R   EE+R++R EE+  
Sbjct: 731 KAKAAK----LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 786

Query: 136 KERHEAVVRRTMER 149
           + + E  +RR  E+
Sbjct: 787 RRKQEEALRRQREQ 800



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 5/93 (5%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           +R   ER+ + E +    EI+  ++EE  ++  E+ L  RK+    +RQ+E+        
Sbjct: 749 KREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---- 804

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            RRQR EE++++ E  +RR  ER ++ +++  +
Sbjct: 805 -RRQREEEERQQQEEALRRLEERRREEEERRKQ 836



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 24/74 (32%), Positives = 41/74 (55%), Gaps = 1/74 (1%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           +  A+  REE E Q    E      EE AR  +E+  E ++K LE QRQKE  R+   ++
Sbjct: 845 EEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEE-ERKRKELEVQRQKELMRQRQQQQ 903

Query: 127 KRRQRLEEDKERHE 140
           +  +RL++ +++ +
Sbjct: 904 EALRRLQQQQQQQQ 917



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 19/56 (33%), Positives = 33/56 (58%)

Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           + LE+ K    EQ ++E   RA  EE+ R+R EE + + E ++RR  E  +K +++
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 40/184 (21%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 386  EKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAP 445
            E+E Q+   E  L+      ++     EER   E EV      M        A       
Sbjct: 854  EEEAQRRLEENRLRMEEEAARLRHEE-EERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 912

Query: 446  APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ----REKEERER 501
                  A +  PSS+     S  T+  +    +AT  LAE ++L  E+    RE++ R++
Sbjct: 913  QQQQQLAQMKLPSSSTWGQQSNTTACQS----QATLSLAEIQKLEEERERQLREEQRRQQ 968

Query: 502  REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561
            RE  +  +Q++++  Q+++      +   + +   E  +E+  Q+Q+Q +++  ++ ++ 
Sbjct: 969  RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ--QQHQQP 1026

Query: 562  ERAQ 565
             RA+
Sbjct: 1027 NRAR 1030



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 34/129 (26%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           R+   +  AR R EE E++   +E+    ++E  RQ  ++  +E  +RL++Q+Q+++  +
Sbjct: 865 RLRMEEEAARLRHEEEERK--RKELEVQRQKELMRQRQQQ--QEALRRLQQQQQQQQLAQ 920

Query: 122 AAV------------------------------EEKRRQRLEEDKERHEAVVRRTMERSQ 151
             +                              EE+ RQ  EE + +   +++   ++ Q
Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQ 980

Query: 152 KPKQKHNRW 160
           + +QK + W
Sbjct: 981 QQQQKLSGW 989



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 14/160 (8%)

Query: 355 KAAPAQVRPPSPGNIRPVKR---EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEAT 411
           + + +  RP +P + +  +    E K EP+ +  EK  ++   E SL  + P  + +E  
Sbjct: 372 QTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPS-RGDEMV 430

Query: 412 VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA 471
            + + P          +  P+  ++P     P P P P+P +    +  V A      S 
Sbjct: 431 ADVQQPL---------SQIPSDTASPL-LILPPPVPNPSPTLRPVETPVVGAPGMGSVST 480

Query: 472 GTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK 511
              D E    L  +  ++    ++    + R   +L+  +
Sbjct: 481 EPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHR 520



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 36/155 (23%), Positives = 72/155 (46%), Gaps = 36/155 (23%)

Query: 39   PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQH 98
            P+S+  GQ +N +  +      L + + Q+L     EERE+QL         REE+ RQ 
Sbjct: 924  PSSSTWGQQSNTTACQSQA--TLSLAEIQKL----EEERERQL---------REEQRRQQ 968

Query: 99   YEKHLEERKKRLEEQRQKEERR--------RAAVEEKRRQRLEEDKERHEAVVRRTMERS 150
                  E  K L++Q+Q+++++        + +   K    +++++ R     ++  ++ 
Sbjct: 969  -----RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1023

Query: 151  QKPKQKHN------RWSWGGSLHGSPSIHSADPDR 179
            Q+P +  N        S G S+ G  SI++  P++
Sbjct: 1024 QQPNRARNNTHSNLHTSIGNSVWG--SINTGPPNQ 1056


>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
           sapiens]
          Length = 1299

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 26/234 (11%)

Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATR----------LLAEK 486
           P   + P PA      +  A ++ +             + EE  R          +L  +
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 772

Query: 487 RRLAREQREKEERERREQEE-LERQKREELA---QRVAEERTTRREE----ESRRLEAEQ 538
           +   R++RE+EE  RR+QEE L RQ+ +E+A   QR  EER  + E     E RR E E+
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832

Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598
            R++EE L++Q EE A   REE E  +R +E   R+ EEA R+R E E+  ++E    LE
Sbjct: 833 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE----LE 888

Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL----TGGTEVSALPCTTNA 648
            +++ E + +R ++ EA  +    Q+   +A+  L    T G + +   C + A
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQA 942



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 46/163 (28%), Positives = 87/163 (53%), Gaps = 25/163 (15%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVAEERTTRREEESRRLE 535
           EEA R L E+RR   E+R++EE  R+++EE  +  REE  AQR  EE   R EEE+ RL 
Sbjct: 817 EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 876

Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER--------------- 580
            E+   K ++L+ Q ++  +R+R++ + A R+ +++ + ++ A+                
Sbjct: 877 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTT 936

Query: 581 ---------VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
                    + + ++   +RE Q R E++++  E+MK  ++ +
Sbjct: 937 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 979



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 26/87 (29%), Positives = 53/87 (60%), Gaps = 2/87 (2%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           ++ + R ++EE  K+    E+   ++EE  R+  E+ +  R++R EE+RQ++E     +E
Sbjct: 765 QEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 824

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQK 152
           E+RR+  EE++ + E ++R+  E + K
Sbjct: 825 ERRRE--EEERRKQEELLRKQEEEAAK 849



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 24/157 (15%)

Query: 475  DPEEATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
            + EEA R L E R       AR + E+EER+R+   ELE Q+++EL +     +  +++E
Sbjct: 853  EEEEAQRRLEENRLRMEEEAARLRHEEEERKRK---ELEVQRQKELMR-----QRQQQQE 904

Query: 530  ESRRLEAEQAREKEEQLQ--------RQAEERALREREEAERAQRQKEEEAR---VREEA 578
              RRL+ +Q +++  Q++        +Q+   A + +     A+ QK EE R   +REE 
Sbjct: 905  ALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQ 964

Query: 579  ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
             R ++E  K  Q+++Q++ ++      + K +  T++
Sbjct: 965  RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS 1001



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 21/109 (19%)

Query: 65  DRQRLARERREE-----REKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQK 116
           + + LAR ++EE     RE+++A R     +REE  RQ  E   + LEER++  EE+R++
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRR----QREEEERQQQEEALRRLEERRREEEERRKQ 836

Query: 117 EERRR---------AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           EE  R         A  EE+ ++RLEE++ R E    R     ++ K+K
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 27/98 (27%), Positives = 55/98 (56%), Gaps = 11/98 (11%)

Query: 62  RVDDRQRLARERREERE--KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ-----R 114
           R+++R+R   ERR++ E  ++       W   EE A    ++ LEE + R+EE+      
Sbjct: 822 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA----QRRLEENRLRMEEEAARLRH 877

Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
           ++EER+R  +E +R++ L   +++ +  +RR  ++ Q+
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQ 915



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 17/134 (12%)

Query: 19  RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
           RS + PD+  + + +  +S+P     G   +   +   P P L          E+ ++ E
Sbjct: 681 RSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL----------EQLQQLE 730

Query: 79  KQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAVEEKRRQRLEED-- 135
           K  AA+    LE+E R  +   K  EE +KR EE +RQ+EE  R   EE+R++R EE+  
Sbjct: 731 KAKAAK----LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 786

Query: 136 KERHEAVVRRTMER 149
           + + E  +RR  E+
Sbjct: 787 RRKQEEALRRQREQ 800



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 5/93 (5%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           +R   ER+ + E +    EI+  ++EE  ++  E+ L  RK+    +RQ+E+        
Sbjct: 749 KREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---- 804

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            RRQR EE++++ E  +RR  ER ++ +++  +
Sbjct: 805 -RRQREEEERQQQEEALRRLEERRREEEERRKQ 836



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 24/74 (32%), Positives = 41/74 (55%), Gaps = 1/74 (1%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           +  A+  REE E Q    E      EE AR  +E+  E ++K LE QRQKE  R+   ++
Sbjct: 845 EEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEE-ERKRKELEVQRQKELMRQRQQQQ 903

Query: 127 KRRQRLEEDKERHE 140
           +  +RL++ +++ +
Sbjct: 904 EALRRLQQQQQQQQ 917



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 19/56 (33%), Positives = 33/56 (58%)

Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           + LE+ K    EQ ++E   RA  EE+ R+R EE + + E ++RR  E  +K +++
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 40/184 (21%), Positives = 81/184 (44%), Gaps = 11/184 (5%)

Query: 386  EKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAP 445
            E+E Q+   E  L+      ++     EER   E EV      M        A       
Sbjct: 854  EEEAQRRLEENRLRMEEEAARLRHEE-EERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 912

Query: 446  APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ----REKEERER 501
                  A +  PSS+     S  T+  +    +AT  LAE ++L  E+    RE++ R++
Sbjct: 913  QQQQQLAQMKLPSSSTWGQQSNTTACQS----QATLSLAEIQKLEEERERQLREEQRRQQ 968

Query: 502  REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561
            RE  +  +Q++++  Q+++      +   + +   E  +E+  Q+Q+Q +++  ++ ++ 
Sbjct: 969  RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ--QQHQQP 1026

Query: 562  ERAQ 565
             RA+
Sbjct: 1027 NRAR 1030



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 34/129 (26%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           R+   +  AR R EE E++   +E+    ++E  RQ  ++  +E  +RL++Q+Q+++  +
Sbjct: 865 RLRMEEEAARLRHEEEERK--RKELEVQRQKELMRQRQQQ--QEALRRLQQQQQQQQLAQ 920

Query: 122 AAV------------------------------EEKRRQRLEEDKERHEAVVRRTMERSQ 151
             +                              EE+ RQ  EE + +   +++   ++ Q
Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQ 980

Query: 152 KPKQKHNRW 160
           + +QK + W
Sbjct: 981 QQQQKLSGW 989



 Score = 30.8 bits (68), Expect = 4.8
 Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 14/160 (8%)

Query: 355 KAAPAQVRPPSPGNIRPVKR---EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEAT 411
           + + +  RP +P + +  +    E K EP+ +  EK  ++   E SL  + P  + +E  
Sbjct: 372 QTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPS-RGDEMV 430

Query: 412 VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA 471
            + + P          +  P+  ++P     P P P P+P +    +  V A      S 
Sbjct: 431 ADVQQPL---------SQIPSDTASPL-LILPPPVPNPSPTLRPVETPVVGAPGMGSVST 480

Query: 472 GTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK 511
              D E    L  +  ++    ++    + R   +L+  +
Sbjct: 481 EPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHR 520



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 36/155 (23%), Positives = 72/155 (46%), Gaps = 36/155 (23%)

Query: 39   PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQH 98
            P+S+  GQ +N +  +      L + + Q+L     EERE+QL         REE+ RQ 
Sbjct: 924  PSSSTWGQQSNTTACQSQA--TLSLAEIQKL----EEERERQL---------REEQRRQQ 968

Query: 99   YEKHLEERKKRLEEQRQKEERR--------RAAVEEKRRQRLEEDKERHEAVVRRTMERS 150
                  E  K L++Q+Q+++++        + +   K    +++++ R     ++  ++ 
Sbjct: 969  -----RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1023

Query: 151  QKPKQKHN------RWSWGGSLHGSPSIHSADPDR 179
            Q+P +  N        S G S+ G  SI++  P++
Sbjct: 1024 QQPNRARNNTHSNLHTSIGNSVWG--SINTGPPNQ 1056


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 87.8 bits (216), Expect = 3e-17
 Identities = 62/189 (32%), Positives = 103/189 (54%), Gaps = 27/189 (14%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQE-----ELERQKREELAQRVAEER---TTRRE 528
           E  TR   +K R +  ++E+ ERE+R++E     + ER K+E+  +R  EER     RRE
Sbjct: 44  EIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRRE 103

Query: 529 EESRRLEAEQAREKEEQLQR--------QAEERALREREEAERAQRQKEEEARVREEAER 580
           +E++  E ++ R+K+E+ +R        + E +  R+REE +  +R+KEE  + RE  ER
Sbjct: 104 KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKER 163

Query: 581 VRQER----EKHFQREEQERLERKK-------RLEEIMKRTRRTEATDKKTSDQRNGDIA 629
            ++ER    EK  +R+E+ER ERKK       R +E  ++ RR    ++K  ++R  +  
Sbjct: 164 KKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQ 223

Query: 630 KGALTGGTE 638
           K   T   E
Sbjct: 224 KDRQTNWRE 232



 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 52/149 (34%), Positives = 92/149 (61%), Gaps = 7/149 (4%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA-EQAREKE 543
           E+R   + +REKE +E  E+E+ ++++++E  +   E +   R+EE +R E  E+ R+KE
Sbjct: 93  EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152

Query: 544 E-QLQRQAEERALREREE-AERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKK 601
           E + +R+ +ER  RER++  E+ + +KE+E + R++ ER R+ER+K  +RE +ER ERKK
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK--ERERKERRERKK 210

Query: 602 RLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
             E   K  R+ E    + ++ R  +  K
Sbjct: 211 --ERKKKEERKKERQKDRQTNWREKERGK 237



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 45/138 (32%), Positives = 78/138 (56%), Gaps = 5/138 (3%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRRE-EESRRLE 535
           E+  R   EK+   R  +E +ERER+E+ + E +K  E   R  EER   RE +E ++ E
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE---RKKEEREKERERKERKKRE 167

Query: 536 AEQAREKEEQL-QRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
            +Q  EKEE+  +++ +ER  RER   ER + ++ +E R R++  + ++ER+K  Q++ Q
Sbjct: 168 RKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQ 227

Query: 595 ERLERKKRLEEIMKRTRR 612
                K+R +   K  ++
Sbjct: 228 TNWREKERGKRERKERKK 245



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 35/131 (26%), Positives = 74/131 (56%), Gaps = 4/131 (3%)

Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKE 543
           +E R   RE   ++E ++  + E ++++RE   ++   E+  +RE   +  + E+ +E+ 
Sbjct: 36  SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER 95

Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
           E+ +R+ E    +E +E E  +++K++E + R    +  +ERE+  +R+ +ER ER+++ 
Sbjct: 96  ERKKRRRE----KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKK 151

Query: 604 EEIMKRTRRTE 614
           EE  K   R E
Sbjct: 152 EEREKERERKE 162



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 42/127 (33%), Positives = 76/127 (59%), Gaps = 9/127 (7%)

Query: 498 ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRE 557
           + E RE+E     ++E   +R +E +  RRE E R+ E E+ R++E   + + E++  R+
Sbjct: 35  QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE---RGKKEKKGERK 91

Query: 558 REEAERAQRQKEEEARVREEAERVRQEREKHFQR-----EEQERLERKKRLEEIMKRTRR 612
           +EE ER +R++E+E +  EE E+ +++ +K   R     +E+ER E +KR EE  +R R+
Sbjct: 92  KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR-EERKERERK 150

Query: 613 TEATDKK 619
            E  +K+
Sbjct: 151 KEEREKE 157



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 32/111 (28%), Positives = 64/111 (57%), Gaps = 1/111 (0%)

Query: 520 AEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE 579
           +E R   RE E+R+ E ++ RE E + +R+  E+  RERE+  + +R K+E+   R++ E
Sbjct: 36  SEIREREREIETRK-EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94

Query: 580 RVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
           R R++R +  + +E E  E++K+ E+  +     E  +++  ++R  +  K
Sbjct: 95  RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK 145



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 30/99 (30%), Positives = 57/99 (57%), Gaps = 4/99 (4%)

Query: 62  RVDDRQRLARERRE----EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKE 117
           R ++R+R  R+ RE    EREK+   +E    ER++   +  E+  +ERK+R + +R ++
Sbjct: 135 RKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRK 194

Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           ER++    ++RR+R +E K++ E    R  +R    ++K
Sbjct: 195 ERKKERERKERRERKKERKKKEERKKERQKDRQTNWREK 233



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 35/106 (33%), Positives = 58/106 (54%), Gaps = 13/106 (12%)

Query: 65  DRQRLARERREEREKQLAAREIVW------LEREERARQHYEKHLEERKKRLEEQRQKEE 118
           +R++  RER +ER+++   +E          ER++R R+   K  EE++KR  ++++K+E
Sbjct: 65  EREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKR--KKKEKKE 122

Query: 119 RRRAAVEEKRRQRL-----EEDKERHEAVVRRTMERSQKPKQKHNR 159
           R R + E K R+R      EE KER      R  ER +K ++K  R
Sbjct: 123 RGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRER 168



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 1/99 (1%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYE-KHLEERKKRLEEQRQKEERRRAA 123
           +R+R    +REER+++   +E    ERE + R+  E K + E+++  +E+ +KE ++R  
Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
             ++R++  E  + R     R+  E  +K +QK  + +W
Sbjct: 192 NRKERKKERERKERRERKKERKKKEERKKERQKDRQTNW 230



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 13/110 (11%)

Query: 63  VDDRQRLARERREEREKQLAAREIVWLERE-ERARQHYEKHLE--------ERKKRLEEQ 113
           ++ R+   +ER  ER+K+   RE    ERE ER R+  +K  +        ERKKR  E+
Sbjct: 45  IETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREK 104

Query: 114 RQKE----ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
             KE    E+R+   +++R +  +E KER     R+  ER ++ ++K  R
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 31/101 (30%), Positives = 56/101 (55%), Gaps = 8/101 (7%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL-------EEQRQKEE 118
           R+R  +E++ ER+K+   R+    E+E +  +  EK  ++ KK         +E+ +KEE
Sbjct: 79  RERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEE 138

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           R+R   +E+ R++ E +KER E   R+  ER Q  +++  R
Sbjct: 139 RKREERKERERKKEEREKER-ERKERKKRERKQVGEKEEER 178



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 29/91 (31%), Positives = 54/91 (59%), Gaps = 6/91 (6%)

Query: 63  VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEER-KKRLEEQRQKEERRR 121
           + +R+R    R+E ++++ + R+    ERE+R R+  ++   ER KK  + +R+KEER  
Sbjct: 38  IREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER-- 95

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
              E K+R+R +E+KE  E   R+  E+ ++
Sbjct: 96  ---ERKKRRREKENKEGEEKEKRKKKEKKER 123



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 24/95 (25%), Positives = 55/95 (57%), Gaps = 4/95 (4%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           +++R  +ER++   KQ+  +E    ER+E+ R+  +K    RK+R +E+ +KE R R   
Sbjct: 155 EKERERKERKKRERKQVGEKEE---ERKEKERKERKKRERNRKERKKERERKERRERKK- 210

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           E K+++  ++++++      R  ER ++ +++  +
Sbjct: 211 ERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 27/97 (27%), Positives = 52/97 (53%), Gaps = 2/97 (2%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYE-KHLEERKKRLEEQRQKEERRRA 122
           ++R+R  R R +E ++     +    E++ER R   E K  E +++R  E+R++ ER++ 
Sbjct: 93  EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              EK R+R E  K   + V  +  ER +K +++  +
Sbjct: 153 E-REKERERKERKKRERKQVGEKEEERKEKERKERKK 188



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 23/96 (23%), Positives = 58/96 (60%), Gaps = 5/96 (5%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           ++++   +E+R+++EK+   R     E +ER R+   K  E +++  +++ +++ER R  
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSK--EGKERERKEERKREERKERERKKEEREKERERKE 162

Query: 124 VEEKRRQRL---EEDKERHEAVVRRTMERSQKPKQK 156
            +++ R+++   EE+++  E   R+  ER++K ++K
Sbjct: 163 RKKRERKQVGEKEEERKEKERKERKKRERNRKERKK 198



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 2/70 (2%)

Query: 90  EREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMER 149
           ERE       E   E   +R +E+R++E+R+R   +E++R+R +++K+       R  ER
Sbjct: 40  EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER--ER 97

Query: 150 SQKPKQKHNR 159
            ++ ++K N+
Sbjct: 98  KKRRREKENK 107



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 20/68 (29%), Positives = 37/68 (54%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           ++R+   R+ R++RE+    R+     +E R R+   K  EERKK  ++ RQ   R +  
Sbjct: 176 EERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKER 235

Query: 124 VEEKRRQR 131
            + +R++R
Sbjct: 236 GKRERKER 243



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 14/57 (24%), Positives = 35/57 (61%), Gaps = 3/57 (5%)

Query: 99  YEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
           ++  + ER++ +E +++ ++ R +  +++RR+R +  +ER +    R  ER +K K+
Sbjct: 34  WQSEIREREREIETRKEGKKERESERKKERREREKRKREREK---ERKRERGKKEKK 87


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 83.6 bits (205), Expect = 6e-16
 Identities = 51/160 (31%), Positives = 93/160 (58%), Gaps = 10/160 (6%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKRE------ELAQRVAEERTTRREEE 530
           E+  R   E+ +    +R++ E++R+E+ E ER+KR+      E  QR   ER  ++E +
Sbjct: 62  EKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERK 121

Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE--RVRQEREKH 588
            R  E +Q RE++ + +R+ + R  R+RE+ ER +R+++ + R +EE E  R R  +E+ 
Sbjct: 122 ERERENKQRRERKRKKRRKKKRRKERKREK-ERGKRERKRKKRKKEEREKKRERNRKERK 180

Query: 589 FQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDI 628
            +RE +ER ERKK  ++  +R ++    D+KT  Q +  +
Sbjct: 181 KERERKERRERKKERKK-ERRKKKERKKDRKTDRQTDSQV 219



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 44/143 (30%), Positives = 86/143 (60%), Gaps = 5/143 (3%)

Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQ 545
           +R+  R +REK +RER ++ + ER K+E+  +R   ER   RE + +  E ++   +E++
Sbjct: 35  ERKKERREREKRKREREKERKRERGKKEK-KKRKKRERGKERERKRKEREKQRKERREKE 93

Query: 546 LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLE- 604
            +++ +E+  RER++  R +R+K++E + RE   + R+ER++  +R+++ R ERK+  E 
Sbjct: 94  RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER 153

Query: 605 ---EIMKRTRRTEATDKKTSDQR 624
              E  ++ R+ E  +KK    R
Sbjct: 154 GKRERKRKKRKKEEREKKRERNR 176



 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 41/143 (28%), Positives = 83/143 (58%), Gaps = 3/143 (2%)

Query: 485 EKRRLAREQREKEER---ERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQARE 541
           EKR+  RE+  K ER   E++++++ ER K  E  ++  E++   R E+ RR   ++ ++
Sbjct: 44  EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKK 103

Query: 542 KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKK 601
           +E + + + E +  +ER+E ER  +Q+ E  R +   ++ R+ER++  +R ++ER  +K+
Sbjct: 104 RERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKR 163

Query: 602 RLEEIMKRTRRTEATDKKTSDQR 624
           + EE  K+  R     KK  +++
Sbjct: 164 KKEEREKKRERNRKERKKERERK 186



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 42/134 (31%), Positives = 76/134 (56%), Gaps = 12/134 (8%)

Query: 491 REQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQA 550
           RE   K+ER  RE+ + ER+K          ER   R ++ ++   ++ R KE + +R+ 
Sbjct: 32  RESERKKERREREKRKREREK----------ERKRERGKKEKKKRKKRERGKERERKRKE 81

Query: 551 EERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRT 610
            E+  +ER E ER +R+KE+  + RE  +R R+ER+K  +R+E+ER  +++R  +  KR 
Sbjct: 82  REKQRKERREKERRKRKKEK--KKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139

Query: 611 RRTEATDKKTSDQR 624
           ++    ++K   +R
Sbjct: 140 KKKRRKERKREKER 153



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 26/118 (22%), Positives = 69/118 (58%), Gaps = 1/118 (0%)

Query: 486 KRRLAREQREKEER-ERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
           K+R  RE+++K+ER ER  + +  R+++ +  ++    +  +RE+E  + E ++ + K+E
Sbjct: 107 KQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKE 166

Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKR 602
           + +++ E      ++E ER +R++ ++ R +E  ++  +++++   R+   ++ R  R
Sbjct: 167 EREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLR 224



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 28/95 (29%), Positives = 58/95 (61%), Gaps = 1/95 (1%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           +R++  RER +ER+++   +E    ++ ER ++  E+  +ER+K+ +E+R+KE R+R   
Sbjct: 42  EREKRKREREKERKRERGKKEKKKRKKRERGKER-ERKRKEREKQRKERREKERRKRKKE 100

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           ++KR ++    +ER +   R+  ER  K +++  R
Sbjct: 101 KKKRERKQRGRRERKKKKERKERERENKQRRERKR 135



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 30/97 (30%), Positives = 58/97 (59%), Gaps = 12/97 (12%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR---RA 122
           R+R  R RRE ++K+         ER+ER R++ ++   +RKKR +++R+KE +R   R 
Sbjct: 104 RERKQRGRRERKKKK---------ERKERERENKQRRERKRKKRRKKKRRKERKREKERG 154

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
             E KR++R +E++E+     R+  ++ ++ K++  R
Sbjct: 155 KRERKRKKRKKEEREKKRERNRKERKKERERKERRER 191



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 31/96 (32%), Positives = 59/96 (61%), Gaps = 9/96 (9%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           + ++R  RER +ERE++   RE    +R+ER  +   K  +E+KKR  +QR + ER++  
Sbjct: 62  EKKKRKKRERGKERERKRKERE---KQRKERREKERRKRKKEKKKRERKQRGRRERKK-- 116

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            +++R++R  E+K+R E   R+  +R +K ++K  +
Sbjct: 117 -KKERKERERENKQRRE---RKRKKRRKKKRRKERK 148



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 34/124 (27%), Positives = 67/124 (54%), Gaps = 5/124 (4%)

Query: 33  KNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLERE 92
           K  SSR A  ++ +    S +    P   R  +R++  RER + + ++   R+    ++E
Sbjct: 3   KAISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKE 62

Query: 93  ERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
           ++ R+  E+  E  +KR E ++Q++ERR     EK R++ +++K++ E   R   ER +K
Sbjct: 63  KKKRKKRERGKERERKRKEREKQRKERR-----EKERRKRKKEKKKRERKQRGRRERKKK 117

Query: 153 PKQK 156
            ++K
Sbjct: 118 KERK 121



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 6/95 (6%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLE-EQRQKEERRRAAV 124
           R+   ++R+E REK+   R     ++E++ R+  ++   ERKK+ E ++R++E ++R   
Sbjct: 79  RKEREKQRKERREKERRKR-----KKEKKKRERKQRGRRERKKKKERKERERENKQRRER 133

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           + K+R++ +  KER     R   ER +K ++K  R
Sbjct: 134 KRKKRRKKKRRKERKREKERGKRERKRKKRKKEER 168



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 25/95 (26%), Positives = 58/95 (61%), Gaps = 1/95 (1%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           +R++  +ERRE +E++   +E    ER++R R+  +K  E +++  E ++++E +R+   
Sbjct: 81  EREKQRKERRE-KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           ++KRR+  + +KER +   +R   + ++ ++K  R
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEEREKKRER 174



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 29/95 (30%), Positives = 49/95 (51%), Gaps = 4/95 (4%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           +R+   RE ++ RE++   R      +E +  +   K   +RKKR +E+R+K+  R    
Sbjct: 119 ERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKE 178

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            +K R+R    KER E    R  ER +K ++K +R
Sbjct: 179 RKKERER----KERRERKKERKKERRKKKERKKDR 209



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 26/108 (24%), Positives = 62/108 (57%), Gaps = 2/108 (1%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE-ESRRLEAEQAREKE 543
           E+    R +R++++R R+++   ER++ +E  +R  + +  ++EE E +R    + R+KE
Sbjct: 124 ERENKQRRERKRKKR-RKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKE 182

Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
            + + + E +  R++E  ++ +R+K+ +   + +++  R  RE  F R
Sbjct: 183 RERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNR 230



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 23/88 (26%), Positives = 51/88 (57%), Gaps = 3/88 (3%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           R++  R +  +REK+   RE    +R++R ++  EK  E  +K  +++R+++ERR    E
Sbjct: 138 RRKKKRRKERKREKERGKRE---RKRKKRKKEEREKKRERNRKERKKERERKERRERKKE 194

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKP 153
            K+ +R ++++++     R+T  +  +P
Sbjct: 195 RKKERRKKKERKKDRKTDRQTDSQVFRP 222



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 21/98 (21%), Positives = 52/98 (53%), Gaps = 1/98 (1%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           R  +R++  +E+++   KQ   RE    ++E + R+   K   ERK++   ++++ + R+
Sbjct: 90  REKERRKRKKEKKKRERKQRGRRERK-KKKERKERERENKQRRERKRKKRRKKKRRKERK 148

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              E  +R+R  + +++ E   +R   R ++ K++  +
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERK 186



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 2/88 (2%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ--KEERRR 121
           +++QR  R+R++ R+K+         ER +R R+  ++  EER+K+ E  R+  K+ER R
Sbjct: 126 ENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERER 185

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMER 149
               E++++R +E +++ E    R  +R
Sbjct: 186 KERRERKKERKKERRKKKERKKDRKTDR 213



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 22/80 (27%), Positives = 44/80 (55%), Gaps = 2/80 (2%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           + E   R    K+R   E+ +K ER R+E++  + ++R+E  +R  E +  RR+++ R+ 
Sbjct: 150 EKERGKRERKRKKRKKEEREKKRERNRKERK--KERERKERRERKKERKKERRKKKERKK 207

Query: 535 EAEQAREKEEQLQRQAEERA 554
           + +  R+ + Q+ R   E A
Sbjct: 208 DRKTDRQTDSQVFRPLRESA 227



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 21/72 (29%), Positives = 42/72 (58%), Gaps = 5/72 (6%)

Query: 558 REEAERAQRQKEEEARVRE-----EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRR 612
           + E+ER + ++E E R RE     + ER ++E++K  +RE  +  ERK++  E  ++ RR
Sbjct: 31  QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90

Query: 613 TEATDKKTSDQR 624
            +   K+  +++
Sbjct: 91  EKERRKRKKEKK 102



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 21/85 (24%), Positives = 47/85 (55%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           ++R  R+R +ER K+   R+    E  E+ R+   K  ++ ++R E + +K+ER++   +
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201

Query: 126 EKRRQRLEEDKERHEAVVRRTMERS 150
           +K R++  +   + ++ V R +  S
Sbjct: 202 KKERKKDRKTDRQTDSQVFRPLRES 226



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 27/125 (21%), Positives = 59/125 (47%), Gaps = 5/125 (4%)

Query: 28  KVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIV 87
           K +++K    R       +      NK       +   +++  +ER+ E+E+    R+  
Sbjct: 102 KKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRK 161

Query: 88  WLEREERARQHYEKHLEERKKRLEE----QRQKEERRRAAVEEKRRQRLEEDKERHEAVV 143
             ++EER ++  E++ +ERKK  E     +R+KE ++    +++R++  + D++    V 
Sbjct: 162 KRKKEEREKKR-ERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVF 220

Query: 144 RRTME 148
           R   E
Sbjct: 221 RPLRE 225


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 82.4 bits (202), Expect = 1e-15
 Identities = 64/153 (41%), Positives = 83/153 (54%), Gaps = 9/153 (5%)

Query: 478 EATRLLAEKR-RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E  RL AE+R R+  EQ +K   ER   E  E+   +E  +R AEER   REEE R  E 
Sbjct: 268 ERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE- 326

Query: 537 EQAREKEEQLQRQAEERALREREE---AERAQRQKEEEARVREEAERVRQEREKHFQREE 593
           E+ R KEE+ +R AEER   + EE   AE  QR KEEE R  EE +R R E E+  + EE
Sbjct: 327 ERQRIKEEE-KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE 385

Query: 594 QERLERKKRLEEIMKRTRRTEATDKKTSDQRNG 626
           Q   +R K+LEE     + T+   +K   +  G
Sbjct: 386 Q---KRNKQLEEKKHAMQETKIKGEKVEQKIEG 415



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 48/141 (34%), Positives = 79/141 (56%), Gaps = 6/141 (4%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           + E+  R  AE+ RL  E+RE+ + E+ ++   ER + E   +  A+ER  R  EE  R+
Sbjct: 258 EEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERM 317

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
             E+ R  EE+ QR  EE    E+  AE  QR KEEE R  EE +R+++E ++  +  ++
Sbjct: 318 REEEKRAAEER-QRIKEE----EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 372

Query: 595 ERLERKKRLE-EIMKRTRRTE 614
            R E +++ + E  KR ++ E
Sbjct: 373 ARAEEEEKAKVEEQKRNKQLE 393



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 52/168 (30%), Positives = 82/168 (48%), Gaps = 9/168 (5%)

Query: 459 STVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK-REELAQ 517
           S  N   S +      + E+ +  ++   ++  E +E+ E ER   E  ER++ + E  +
Sbjct: 227 SLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDK 286

Query: 518 RVAEERTTRREEESRRLEAEQAREKEE-QLQRQAEERALREREEAERAQRQKEEEARVRE 576
           ++A+ER     EE    +  + RE EE +  R+ E+RA  ER      QR KEEE R  E
Sbjct: 287 KIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEER------QRIKEEEKRAAE 340

Query: 577 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           E +R+++E EK    E Q   E +KR  E  +R R  E    K  +Q+
Sbjct: 341 ERQRIKEE-EKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQK 387



 Score = 74.7 bits (182), Expect = 3e-13
 Identities = 56/170 (32%), Positives = 90/170 (52%), Gaps = 11/170 (6%)

Query: 477 EEATRLLAEKRRL-AREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
           E+  ++  E+ R+ A E+   +ERERRE EE ER + EE  +R AEER   +EEE R  E
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMREEE--KRAAEERQRIKEEEKRAAE 340

Query: 536 AEQAREKEEQLQRQAEERALREREE--AERAQRQKEEEARVREEAERVRQEREKHFQREE 593
            E+ R KEE+ +   E + ++E E+  AE  QR + EE    E+A+   Q+R K  + ++
Sbjct: 341 -ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEE---EEKAKVEEQKRNKQLEEKK 396

Query: 594 QERLERKKRLEEIMKRTRRTEATDKKTSDQR--NGDIAKGALTGGTEVSA 641
               E K + E++ ++       +KK  + +     + K     GT+V A
Sbjct: 397 HAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQA 446



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 63/236 (26%), Positives = 112/236 (47%), Gaps = 24/236 (10%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER-TTRREEESRRLE 535
           EE  R+  E++R A E++  +E E+R  EE +R K EE  +R AEER   R EEE +   
Sbjct: 326 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE--KRAAEERQRARAEEEEKAKV 383

Query: 536 AEQAREKEEQLQRQAEERALREREEAE-----------RAQRQKEEEARVREEAE----R 580
            EQ R K+ + ++ A +    + E+ E           +AQ  K + A ++++ E    +
Sbjct: 384 EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK 443

Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVS 640
           V+ +REK   +E++   ++++  +E +K+ +  +   K   D++ G     +  G     
Sbjct: 444 VQAKREK--LQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 501

Query: 641 ALPCTTNAPGNGKPVGSPHVVTSH-QSKVTVESTPDLEKQPNENGVSVQNENFEEI 695
            L  T N     +P G   V T   +    VE+   LE+     G   ++E FE++
Sbjct: 502 KLKHTENT--FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG-ETESEEFEKL 554



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 60/227 (26%), Positives = 102/227 (44%), Gaps = 56/227 (24%)

Query: 447 PVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAR--------------- 491
           P  T A +S PS  +    +      TT+ EE +    E+  +                 
Sbjct: 123 PTITDASLSLPSRRMQNDTAENE---TTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179

Query: 492 -EQREKEERERREQEELERQKREELAQR----VAEERTTRREEES-------RRLEAEQA 539
            E+ +KE++E+ E+EE E+ KR  + +     + EE+TT  +EE+        ++ +E+ 
Sbjct: 180 AEENKKEDKEKEEEEE-EKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238

Query: 540 REKEEQLQRQAE-------ERALREREEAERAQRQKEEEARVREEA------ERVR---- 582
           +++EE+ Q   E       E   +ER EAERA+ + EE  R++ E       ER R    
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298

Query: 583 -----QEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
                QERE+    E +   E +KR  E  +R +  E   K+ +++R
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEE---KRAAEER 342



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 48/139 (34%), Positives = 73/139 (52%), Gaps = 22/139 (15%)

Query: 465 ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERT 524
           A ++        E   R   E+ R+        E E+R  EE +R K EE  +R AEER 
Sbjct: 293 ARIEAEEKAAAQERERREAEERERMR-------EEEKRAAEERQRIKEEE--KRAAEERQ 343

Query: 525 TRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE 584
             +EEE R  E E+ R KEE+ +R AEER        +RA+ ++EE+A+V E+    + E
Sbjct: 344 RIKEEEKRAAE-ERQRIKEEE-KRAAEER--------QRARAEEEEKAKVEEQKRNKQLE 393

Query: 585 REKHFQREEQ---ERLERK 600
            +KH  +E +   E++E+K
Sbjct: 394 EKKHAMQETKIKGEKVEQK 412



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 81/395 (20%), Positives = 152/395 (38%), Gaps = 57/395 (14%)

Query: 373 KREVKVEPEKKDPEKEPQKVA-NEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAP 431
           + + KVE +K++ + E +K A  E  +KG     K+E   V E+   E ++  A      
Sbjct: 378 EEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQG 437

Query: 432 APASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAR 491
                   A                          ++    T   EE      +K +  +
Sbjct: 438 EEKGTKVQAKRE----------------------KLQEDKPTFKKEEIKDEKIKKDKEPK 475

Query: 492 EQREKEERERREQEELERQKREELAQRVAEERTT------RREEESRRLEAEQAREKEEQ 545
           E+ +     ++   E++ Q  E +  ++     T      R   +++  E     E  ++
Sbjct: 476 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535

Query: 546 LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERL-------- 597
           L+     R   E EE E+ +++++E A   EE ++ R+ER K  + EEQ R         
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595

Query: 598 ---ERKKRLEEIMKRTRRTEATDKKTSDQRNG--DIAKGALTGGTEVSALPCTTNAPGNG 652
              E K+RL+E ++R RR EA +K+     +G  D  K       + S+L     A    
Sbjct: 596 REEEEKRRLKEEIER-RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 654

Query: 653 KPV-GSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTN 711
           K V  S  V ++HQ+ +              + +  + E +   I     +KP++   ++
Sbjct: 655 KSVQKSSGVKSTHQAAIV-------------SKIDSRLEQYTSAIEGTKSAKPTKPAASD 701

Query: 712 SESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTA 746
              P   +  I +  ++G +   P   G   ++TA
Sbjct: 702 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETA 736



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 65/247 (26%), Positives = 102/247 (41%), Gaps = 11/247 (4%)

Query: 463 ASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ-KREELAQRVAE 521
           AS   K + G    E   RL  E+ R  R + E EE E+ +Q++ E   + EEL ++  E
Sbjct: 517 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 574

Query: 522 ERTTRREEESRRLEAEQARE-KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
            R    EEE RR + E  R+ +EE+ +R+ +E   R R EA   +RQK  E  + ++ + 
Sbjct: 575 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE-KRQKMPEDGLSDDKKP 633

Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVS 640
            +    K    + +ER E   +  +     + T      +      +    A+ G    S
Sbjct: 634 FKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEG--TKS 691

Query: 641 ALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNEN----GVSVQNENFEEII 696
           A P    A     P      + S   K  V S+P     PN+      V V +   E + 
Sbjct: 692 AKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLT 751

Query: 697 NLPIGSK 703
             P G+K
Sbjct: 752 KTPDGNK 758



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 56/208 (26%), Positives = 87/208 (41%), Gaps = 33/208 (15%)

Query: 497 EERERREQEELERQKREEL---AQRVAEERTTRREEESRRLEAEQAR-EKEEQLQRQAEE 552
           ++ ERR   EL RQKREE+   A+R+A +R    EEE+ R    +AR E+  Q Q +   
Sbjct: 2   DDFERRR--ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59

Query: 553 RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK-KRLEEIMKRTR 611
             + ++ E        +EEA+      +V  + E  F      R ER+ KRL+E ++R +
Sbjct: 60  GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119

Query: 612 R-----TEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQS 666
                 T+A+    S +   D A+   T   E S                      S Q 
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKS---------------------ESRQE 158

Query: 667 KVTVESTPDLEKQPNENGVSVQNENFEE 694
           +  +E T  + K   +N      EN +E
Sbjct: 159 RYEIEETETVTKSYQKNDWRDAEENKKE 186



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 36/93 (38%), Positives = 51/93 (54%), Gaps = 5/93 (5%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAV 124
           R+   RER  E EK+ A       E E+RA +  ++  EE K+  EE QR KEE +RAA 
Sbjct: 309 REAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA- 367

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKH 157
           EE++R R EE++   +A V       Q  ++KH
Sbjct: 368 EERQRARAEEEE---KAKVEEQKRNKQLEEKKH 397



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 38/103 (36%), Positives = 56/103 (54%), Gaps = 9/103 (8%)

Query: 64  DDRQRLARERR---EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEER 119
           D+R R+  E +   +ERE++ A       E E+RA +  ++  EE K+  EE QR KEE 
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPK---QKHNR 159
           +RAA  E+R++  EE+K   E   R   E  +K K   QK N+
Sbjct: 350 KRAA--EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNK 390



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 40/131 (30%), Positives = 61/131 (46%), Gaps = 16/131 (12%)

Query: 26  SYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAARE 85
           ++K++  +N  SRP    S       G      P +    R    R RR E E +     
Sbjct: 500 THKLKHTENTFSRPGGRASVDTKEAEG-----APQVEAGKRLEELRRRRGETESEE---- 550

Query: 86  IVWLEREERARQHYEKHLEERKKRLEEQR---QKEERRRAAVEEKRRQRLEEDKER-HEA 141
               E+ ++ +Q     LEE KK+ EE+R   ++EE+RR   E  R+ R EE+K R  E 
Sbjct: 551 ---FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 607

Query: 142 VVRRTMERSQK 152
           + RR  E ++K
Sbjct: 608 IERRRAEAAEK 618



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 36/137 (26%), Positives = 68/137 (49%), Gaps = 9/137 (6%)

Query: 30  QDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERRE--EREKQLAAREIV 87
           QDKK A  R       +       + +     R+ + ++ A E R+  + E++ AA E  
Sbjct: 284 QDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343

Query: 88  WLEREERARQHYEKHLEERKKRLEEQRQK---EERRRAAVEEKRRQRLEEDKERHEAVVR 144
            ++ EE+      + ++E +KR  E+RQ+   EE  +A VEE++R +  E+K+     ++
Sbjct: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH---AMQ 400

Query: 145 RTMERSQKPKQK-HNRW 160
            T  + +K +QK   +W
Sbjct: 401 ETKIKGEKVEQKIEGKW 417



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 31/133 (23%), Positives = 59/133 (44%), Gaps = 2/133 (1%)

Query: 29  VQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVW 88
           V++K   S      +S +N   S  +P           +    E+ EE +K+ A  E   
Sbjct: 212 VEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERAR 271

Query: 89  LEREERAR--QHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRT 146
           LE EER R     +K + + + R+E + +   + R   E + R+R+ E+++R     +R 
Sbjct: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRI 331

Query: 147 MERSQKPKQKHNR 159
            E  ++  ++  R
Sbjct: 332 KEEEKRAAEERQR 344



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 10/105 (9%)

Query: 65  DRQRLARERRE----EREKQLA-AREIVWLEREERARQHYEKHLEERKKRLEEQ-RQKEE 118
           +R RL  E RE    E++K++A  R  +  E +  A++   +  EER++  EE+ R  EE
Sbjct: 268 ERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEE 327

Query: 119 RRRAAVEEKR----RQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           R+R   EEKR    RQR++E+++R     +R  E  ++  ++  R
Sbjct: 328 RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 372



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 49/177 (27%), Positives = 78/177 (44%), Gaps = 18/177 (10%)

Query: 461 VNASASVKTS-AGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRV 519
           VNA  SV    A TT          E   L R  R +E R++R QE LERQK  +     
Sbjct: 68  VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITD 127

Query: 520 AEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE 579
           A      R  ++   E E   EKEE+ + + E   + E E   ++ ++ +     R+  E
Sbjct: 128 ASLSLPSRRMQNDTAENETT-EKEEKSESRQERYEIEETETVTKSYQKNDW----RDAEE 182

Query: 580 RVRQEREKHFQREEQERLERKKR------LEEIMKRTRRTEATDKK-TSDQRNGDIA 629
             ++++EK     E+E  E+ KR        E+M   + TE+ ++      +NG I+
Sbjct: 183 NKKEDKEK-----EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQIS 234



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 40/161 (24%), Positives = 72/161 (44%), Gaps = 14/161 (8%)

Query: 478 EATRLLAEKRRLAREQREKEE----RERREQEELERQKREELA------QRVAEERTTRR 527
           E  RL AE+    R   ++EE    R RR ++E  RQK+EE +      Q     + +  
Sbjct: 16  EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVP 75

Query: 528 EEESRRLEAEQAREKEEQ---LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE 584
           +EE++        E +++   L+R A     R++   E  +RQKE +  + + +  +   
Sbjct: 76  DEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSR 135

Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
           R ++    E E  E++++ E   +R    E      S Q+N
Sbjct: 136 RMQN-DTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 30/104 (28%), Positives = 55/104 (52%), Gaps = 8/104 (7%)

Query: 64  DDRQRLARERR--EEREKQLA-AREIVWLEREERAR---QHYEKHLEERKKRLEEQRQKE 117
           ++ +R A ER+  +E EK+ A  R+    E EE+A+   Q   K LEE+K  ++E + K 
Sbjct: 347 EEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG 406

Query: 118 ERRRAAVEEK--RRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           E+    +E K    ++ +EDK +   + ++  E+  K + K  +
Sbjct: 407 EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 43/168 (25%), Positives = 71/168 (42%), Gaps = 45/168 (26%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEE---------LERQKREELAQRVAEERTT 525
           D EEA R   E+RR AR+     ER R++QEE         +E   +  +    A+  TT
Sbjct: 33  DEEEAAR---ERRRRARQ-----ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTT 84

Query: 526 R----------------REEESRRLEAEQAREKEEQLQRQAEERAL------REREEAER 563
                            R EE R+   ++A E++++      + +L       + + AE 
Sbjct: 85  NTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAEN 144

Query: 564 AQRQKEEEARVR------EEAERVRQEREKHFQREEQERLERKKRLEE 605
              +KEE++  R      EE E V +  +K+  R+ +E  +  K  EE
Sbjct: 145 ETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE 192



 Score = 32.3 bits (72), Expect = 1.7
 Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 1/61 (1%)

Query: 103 LEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
           +++ ++R E +RQK E  R   E    QR ++D+E   A  RR   R ++ +QK    S 
Sbjct: 1   MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEE-EAARERRRRARQERLRQKQEEESL 59

Query: 163 G 163
           G
Sbjct: 60  G 60



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 117/645 (18%), Positives = 220/645 (34%), Gaps = 131/645 (20%)

Query: 63  VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
           +DD +R    RR++RE+           R E  R  Y+++ ++     EE+  +E RRRA
Sbjct: 1   MDDFERRRELRRQKREEM----------RLEAERIAYQRNDDD-----EEEAARERRRRA 45

Query: 123 AVEEKRRQRLEE------------------DKER------------HEAVVRRTMERSQK 152
             E  R+++ EE                  D+E              EA     + R ++
Sbjct: 46  RQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE 105

Query: 153 PKQKHNRWSWGGSLHGSPSIHSAD---PDRRSVSTMNLSKYVDPVISKRLSSSSATLLNS 209
            +QK  + +        P+I  A    P RR  +    ++  +             +  +
Sbjct: 106 RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET 165

Query: 210 PDRARRLQLSPWESSVVNRL----------LTPTHSFLARSKSTAALSGEAASCSPIIMP 259
               +  Q + W  +  N+             P    +  ++    +  +        + 
Sbjct: 166 ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVV 225

Query: 260 YKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNP 319
               + + S + PK      +GS             KER       L +  R  +     
Sbjct: 226 MSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQD 285

Query: 320 KARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVE 379
           K     R+R+    K+                    AA  + R  +    R  + E +  
Sbjct: 286 KKIADERARIEAEEKA--------------------AAQERERREAEERERMREEEKRAA 325

Query: 380 PEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAP 439
            E++  ++E ++ A E     R  + + E+   EER   + E   AA     A A     
Sbjct: 326 EERQRIKEEEKRAAEE-----RQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEK 380

Query: 440 ASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKR----RLAREQRE 495
           A       V             +A    K      + +   + + EK+    +L     +
Sbjct: 381 AK------VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434

Query: 496 KEERERREQEELERQKREE-----LAQRVAEERTTRREEESRRLEAEQAREK-------- 542
           K+  E+  + + +R+K +E       + + +E+  + +E    +++   R+K        
Sbjct: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494

Query: 543 -----------EEQLQRQAEERALREREEAE-----RAQRQKEEEARVREEAERVRQERE 586
                       E    +   RA  + +EAE      A ++ EE  R R E E    E+ 
Sbjct: 495 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKL 554

Query: 587 KHFQRE--------EQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           K  Q+E        +++R ER+K LEE  +R R+ E  D+K  ++
Sbjct: 555 KQKQQEAALELEELKKKREERRKVLEEEEQR-RKQEEADRKLREE 598


>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
           [Homo sapiens]
          Length = 914

 Score = 81.3 bits (199), Expect = 3e-15
 Identities = 90/361 (24%), Positives = 156/361 (43%), Gaps = 39/361 (10%)

Query: 278 PPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNP----KARQPARSRLWLPS 333
           PP+ + R+R      S   E +      L     R+ +PS+P    K  +P R+ L    
Sbjct: 443 PPQSARRKRSYKQAVSELDEEQHLEDEELQPP--RSKTPSSPCPASKVVRPLRTFLHTVQ 500

Query: 334 KSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPE---KKDPEKEPQ 390
           ++   +  T  P S +     +  P ++ P      R      K E E   ++  E++ +
Sbjct: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR 560

Query: 391 KVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPT 450
           +   E  LK    L KV +A        E +        A                 +  
Sbjct: 561 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ----------------IDE 604

Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEK-RRLAREQREKEER------ERRE 503
               +         A  K +A   +  EA R   E+ RRL   Q+E+EER      ++++
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 664

Query: 504 QEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE---E 560
           +EE ER ++   A+R+AE+R   R E+ RR +  + +E+ EQ +R+ +ER L E+E   E
Sbjct: 665 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ-ERREQERQLAEQERRRE 723

Query: 561 AERAQRQK---EEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATD 617
            ER Q ++   E E  +R + E++++E E+  ++EEQ+RL  ++  EE  K+ +      
Sbjct: 724 QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 783

Query: 618 K 618
           K
Sbjct: 784 K 784



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 65/186 (34%), Positives = 95/186 (51%), Gaps = 19/186 (10%)

Query: 477 EEATRLLAEKRRLAREQREKEERERRE----QEELERQKREELAQRVAEE--RTTRREEE 530
           E+A +  A K+    E R K+E E R     Q+E E ++ +EL Q+  EE     R+  E
Sbjct: 617 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE 676

Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQ-RQKEEEARVRE----EAERVRQER 585
           ++RL  ++ +E+ EQ +R+ E R    RE+  R Q RQ  E+ R RE    +AER  QER
Sbjct: 677 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736

Query: 586 EK--HFQREE-QERLERKKRLEEIMKRTRR--TEATDKKTSDQRNGDIAKGALTGGTEVS 640
           EK    Q+E+ Q  LE KK+ EE  +   R   E  +KK  +      A  AL    +V 
Sbjct: 737 EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAG---ASKALNVTVDVQ 793

Query: 641 ALPCTT 646
           +  CT+
Sbjct: 794 SPACTS 799



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 51/155 (32%), Positives = 93/155 (60%), Gaps = 17/155 (10%)

Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR---LEAEQAR 540
           A++ RLA E+ +K+   ++ +E   R+K+EE A+R+   R  ++EEE RR   L  ++  
Sbjct: 609 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL---RWLQQEEEERRHQELLQKKKE 665

Query: 541 EKEEQLQRQAEERALRE-REEAERAQRQKEEEARVREEAERVRQEREKHF----QREEQE 595
           E++E+L++ AE + L E RE+  R Q ++E+E R +E  E+ R+E+E+      +R EQE
Sbjct: 666 EEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 725

Query: 596 RLERKKRLEE------IMKRTRRTEATDKKTSDQR 624
           RL+ ++ L+E      + K   + E  +KK  +++
Sbjct: 726 RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 85/330 (25%), Positives = 144/330 (43%), Gaps = 52/330 (15%)

Query: 314 VSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVK 373
           V+ + P+  +   +  W P         TP P         K A +    PS G     +
Sbjct: 385 VAAAEPEVPENNGNNSW-PHNDTEIANSTPNP---------KPAASSPETPSAG-----Q 429

Query: 374 REVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAP 433
           +E K + +   P + PQ    + S K     +  E+   +E         P++P     P
Sbjct: 430 QEAKTD-QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPC----P 484

Query: 434 ASAPAPASAPAPAPVPTPAMVSAPSS---TVNASASVKTSAGTTDPEEATRLLAEKRR-- 488
           AS            V    M+  P+S   +V  S   + +    DP+E  R   E  R  
Sbjct: 485 ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRK 544

Query: 489 -----LAREQREKEERERREQEELERQKR-------EELAQRVAEERTTRREEESRRLEA 536
                L R++ E+++R R E+ +L+R++R        E  +++ EE+  + E++  +++ 
Sbjct: 545 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 604

Query: 537 EQAREKEEQLQRQAEER-----ALREREEAERAQRQKEEEARVR----EEAERVRQEREK 587
           +  + KEE+L   AEE+     A ++ EE E  ++Q+EE  R+R    EE ER  QE  +
Sbjct: 605 KTEKAKEERL---AEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661

Query: 588 HFQREEQERLER---KKRLEEIMKRTRRTE 614
             + EEQERL +    KRL E  ++ RR +
Sbjct: 662 KKKEEEQERLRKAAEAKRLAEQREQERREQ 691



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 53/168 (31%), Positives = 95/168 (56%), Gaps = 22/168 (13%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQ-EELERQKREELAQRVAE--ERTTRREEESRR 533
           EE  R   E+ +L RE+R ++  + RE+ E+++ +K++++ Q+ A+  E+T + +EE  R
Sbjct: 556 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE--R 613

Query: 534 LEAEQAREK-------EEQLQRQAEERALR---------EREEAERAQRQKEEE-ARVRE 576
           L  E+A++K       E + +R+ EE A R         ER   E  Q++KEEE  R+R+
Sbjct: 614 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 673

Query: 577 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            AE  R   ++  +R EQER E+++R +E  ++ RR +       ++R
Sbjct: 674 AAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 49/159 (30%), Positives = 88/159 (55%), Gaps = 16/159 (10%)

Query: 478 EATRLLAEKRRLAREQR-----EKEERERREQEELERQKREELAQRVAEERTTRRE-EES 531
           E    + E+++   EQ+     EK E+ + E+   E+ K++  A+++ E    R++ EE+
Sbjct: 582 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 641

Query: 532 RRL----EAEQAREKEEQLQRQAEE--RALREREEAERAQRQKEEEARVREEAERVRQER 585
           RRL    + E+ R  +E LQ++ EE    LR+  EA+R   Q+E+E R +E  E+ R+E+
Sbjct: 642 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 701

Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           E    R EQER E++++L E  +R  +     ++   +R
Sbjct: 702 E----RREQERREQERQLAEQERRREQERLQAERELQER 736



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 139/638 (21%), Positives = 239/638 (37%), Gaps = 128/638 (20%)

Query: 84  REIVWLE--REERAR---QHYEKHLEERKKRLEEQRQKEERRRAAVEEKRR----QRLEE 134
           +++VWLE  +EE  R   + + K  E   K   ++ ++++RR + V+++ R    +RL  
Sbjct: 29  KDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSR 88

Query: 135 DKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPV 194
            K R   +  R +      ++        GS+    +  +A     + +TM L+    P 
Sbjct: 89  RKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAA---AAAAATMALAAPSSPT 145

Query: 195 ISKRLSSSSATLLNSP-DRARRLQLSP-------------------WESSVVNRLLTPTH 234
                  S   L   P D   + QL P                     +  + R L+PT 
Sbjct: 146 -----PESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTP 200

Query: 235 SFLARSKSTAALSGEAASCSPIIMPYKA-AHSRNSMDRPKLFVTP--PEGSSRRRIIHGT 291
           +      +TA  S    +      P K+ A    S+    L  TP  P+G        GT
Sbjct: 201 A-----SATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGV-----GT 250

Query: 292 ASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPP 351
               +   +  +  ++ G R   SP+ P +  P R R+  P   LP    TP   S    
Sbjct: 251 G---RSASKLRIAQVSPGPRD--SPAFPDS--PWRERVLAPI--LPDNFSTPTG-SRTDS 300

Query: 352 GSVKAAPAQVRPPSPGNIRPVKREVKVEPE---KKDPEKEPQKVANEPSLKGRA------ 402
            SV+ +P     PSP  +   K  +  + E   ++   +  +K A EP+  GR       
Sbjct: 301 QSVRHSPIAPSSPSP-QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYL 359

Query: 403 -PLVKVE---EATVEERTPAEPEVGPAAPAMAPAPASA--------PAPASAPAPAPVPT 450
             L+ VE   +   E++ P E E  P A A    P +             +   P P P 
Sbjct: 360 ERLLNVEVPQKVGSEQKEPPE-EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418

Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELE-- 508
            +    PS+     A    + G  +P ++ R    KR   +   E +E +  E EEL+  
Sbjct: 419 ASSPETPSAG-QQEAKTDQADGPREPPQSAR---RKRSYKQAVSELDEEQHLEDEELQPP 474

Query: 509 --------------------------------------RQKREELAQRVAEERTTRREEE 530
                                                 R   +   +R    R   +E+E
Sbjct: 475 RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKE 534

Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
            +RLE  + +E+ EQL+RQ  E   R R E  + +R+ E   +V +  ERV Q +E+  +
Sbjct: 535 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE-ERLRKVLQARERVEQMKEEKKK 593

Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDI 628
           + EQ+  +  ++ E+  +     E   KK + ++  ++
Sbjct: 594 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 631



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 23/117 (19%)

Query: 66  RQRLARERREE----REKQLAAREIVWLEREERARQHYE---KHLEERK---------KR 109
           +++ A ++ EE    R+++  AR + WL++EE  R+H E   K  EE +         KR
Sbjct: 620 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR 679

Query: 110 LEEQRQKEERRRAAVEEKRR-------QRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           L EQR++E R +   E++RR       +R E++++  E   RR  ER Q  ++   R
Sbjct: 680 LAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 29/96 (30%), Positives = 55/96 (57%), Gaps = 7/96 (7%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA-- 122
           +++R  +ERRE+  ++   RE    ER E+ RQ  E+     ++RL+ +R+ +ER +A  
Sbjct: 685 EQERREQERREQERREQERRE---QERREQERQLAEQERRREQERLQAERELQEREKALR 741

Query: 123 AVEEKRRQRLEEDKERHE--AVVRRTMERSQKPKQK 156
             +E+ ++ LEE K++ E   +  R ++  Q+ K K
Sbjct: 742 LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 52/169 (30%)

Query: 36  SSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREI--------- 86
           +S P S +      ++  + DP    +  +RQRL   RR+E  +QL  +++         
Sbjct: 509 TSAPRSVMKSFIKRNTPLRMDP----KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLE 564

Query: 87  -VWLEREER------ARQHYEKHLEERKKRLEE---------QRQKEER----------- 119
            V L+REER      AR+  E+  EE+KK++E+         ++ KEER           
Sbjct: 565 EVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 624

Query: 120 ---------RRAAVEEKRRQRL---EEDKERHEAVVRRTMERSQKPKQK 156
                    RR   EE RR R    EE++ RH+ ++++  E  Q+  +K
Sbjct: 625 AKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 673



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 26/95 (27%), Positives = 52/95 (54%), Gaps = 12/95 (12%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERK---KRLEEQRQKEERRR 121
           + +RLA +R +ER +Q         ER E+ R+  E+  +ER+   ++L EQ ++ E+ R
Sbjct: 676 EAKRLAEQREQERREQ---------ERREQERREQERREQERREQERQLAEQERRREQER 726

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
              E + ++R +  + + E + R   E+ +K +Q+
Sbjct: 727 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 24/88 (27%), Positives = 48/88 (54%), Gaps = 2/88 (2%)

Query: 67  QRLARERREEREKQL--AAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           Q L ++++EE +++L  AA      E+ E+ R+  E+  +ER+++   ++++ E+ R   
Sbjct: 657 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQK 152
           E++RR+  E  +   E   R    R QK
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQK 744



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 2/68 (2%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERA-RQHYEKHLEERKKRLEEQRQKEERR 120
           R  +RQ   +ERR E+E+  A RE+   E+  R  ++  ++ LEE+KK+ EEQ++  ER+
Sbjct: 709 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK-EEQQRLAERQ 767

Query: 121 RAAVEEKR 128
               +EK+
Sbjct: 768 LQEEQEKK 775


>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
           theta, 150/170kDa [Homo sapiens]
          Length = 1382

 Score = 80.9 bits (198), Expect = 4e-15
 Identities = 58/151 (38%), Positives = 86/151 (56%), Gaps = 20/151 (13%)

Query: 473 TTDPEEATRLLAEKRRLAREQREKE---ERERREQEELERQKREELAQRVAEERTTRREE 529
           TT   E  + L  K R++R   +++    R +  ++ +  +K ++  +R+AEER  R EE
Sbjct: 734 TTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEE 793

Query: 530 ESRRLEAEQA----REKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQER 585
             R+ + E+     REKEE+ QR+AEE+ L+EREE ERA+R K EE  +RE  ERV++  
Sbjct: 794 RKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREE-ELREYQERVKK-- 850

Query: 586 EKHFQREEQERLERKKRLE--EIMKRTRRTE 614
                    E +ERKKR    EI +R RR E
Sbjct: 851 --------LEEVERKKRQRELEIEERERRRE 873



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 48/134 (35%), Positives = 74/134 (55%), Gaps = 11/134 (8%)

Query: 495 EKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERA 554
           E++E ER    +LER+K  E   R++      R+    RL+A +    EE+L +Q EER 
Sbjct: 726 EQQEEERITTMQLEREKALEHKNRMSR-MLEDRDLFVMRLKAARQSVYEEKL-KQFEERL 783

Query: 555 LREREEA-ERAQRQKEEEARV-----REEAERVRQEREKHFQREEQERLERKKRLEEI-- 606
             ER    E  +RQ++EE R+     +EE E+ R E +   +REE+ER ER KR EE+  
Sbjct: 784 AEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELRE 843

Query: 607 -MKRTRRTEATDKK 619
             +R ++ E  ++K
Sbjct: 844 YQERVKKLEEVERK 857



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 51/144 (35%), Positives = 80/144 (55%), Gaps = 19/144 (13%)

Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQ 545
           +R LAR Q  +E +ER E   ++R+K EEL QR AE +  R+ EE R  +  + REKE  
Sbjct: 566 QRILARRQTIEERKERLESLNIQREK-EELEQREAELQKVRKAEEERLRQEAKEREKERI 624

Query: 546 LQ--RQAEERALREREEAER-----AQRQKEEEARVREE-------AERVRQ-EREKHFQ 590
           LQ   Q +++ +RER E  +     A+  K+ +    EE       A++V Q E+EK   
Sbjct: 625 LQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEK--- 681

Query: 591 REEQERLERKKRLEEIMKRTRRTE 614
           +E QERL+ +++  +  +R +R E
Sbjct: 682 KELQERLKNQEKKIDYFERAKRLE 705



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 44/118 (37%), Positives = 64/118 (54%), Gaps = 16/118 (13%)

Query: 479 ATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQ 538
           A + + E++    E+R  EER  R  EE +RQ++EE  +R+   R  + EEE RR E + 
Sbjct: 767 ARQSVYEEKLKQFEERLAEERHNR-LEERKRQRKEE--RRITYYRE-KEEEEQRRAEEQM 822

Query: 539 AREKE--EQLQRQAEERALRE-------REEAERAQRQKEEEARVREEAERVRQEREK 587
            +E+E  E+ +R   E  LRE        EE ER +RQ+E E    EE ER R+E  +
Sbjct: 823 LKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEI---EERERRREEERR 877



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 39/118 (33%), Positives = 69/118 (58%), Gaps = 10/118 (8%)

Query: 508 ERQKREELAQRVAEERTTRREEE---SRRLEAEQAREKEEQLQRQAEERALREREEAERA 564
           E++++ +LA   A  + +R+E +   +RR   E+ +E+ E L  Q E+  L +R EAE  
Sbjct: 545 EKEEQHQLAV-TAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQR-EAELQ 602

Query: 565 QRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSD 622
           + +K EE R+R+EA    +EREK    +E E++ +KK + E +++ ++TE   K   D
Sbjct: 603 KVRKAEEERLRQEA----KEREKERILQEHEQI-KKKTVRERLEQIKKTELGAKAFKD 655



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 42/155 (27%), Positives = 77/155 (49%), Gaps = 13/155 (8%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E   RL   KR+   E+R    RE+ E+E+  R + + L +R   ER  R + E    E 
Sbjct: 786 ERHNRLEERKRQRKEERRITYYREKEEEEQ-RRAEEQMLKEREERERAERAKREEELREY 844

Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARV------REEAERVRQEREKHFQ 590
           ++  +K E+++R+  +R L    E E  +R++EEE R+      R+++    ++ E  ++
Sbjct: 845 QERVKKLEEVERKKRQREL----EIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWR 900

Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
           +  +   E ++   E  K  RR E  D+  S +R+
Sbjct: 901 KGPEADSEWRRGPPE--KEWRRGEGRDEDRSHRRD 933



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 33/97 (34%), Positives = 52/97 (53%), Gaps = 13/97 (13%)

Query: 62  RVDDRQRLARERR-------EEREKQLAAREIVWLEREERARQHYEKHLEE------RKK 108
           R+++R+R  +E R       +E E+Q  A E +  EREER R    K  EE      R K
Sbjct: 790 RLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVK 849

Query: 109 RLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRR 145
           +LEE  +K+ +R   +EE+ R+R EE +    ++ R+
Sbjct: 850 KLEEVERKKRQRELEIEERERRREEERRLGDSSLSRK 886



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 49/177 (27%), Positives = 78/177 (44%), Gaps = 25/177 (14%)

Query: 451 PAMVSAPSSTVNASASVKTS--AGTTDPEEATRLLAEKR---RLAREQREKEERERREQE 505
           P + S PS  +    +  +S  A   +  +   +L EK    +LA     K  R+  ++ 
Sbjct: 509 PHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRI 568

Query: 506 ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQ 565
              RQ  EE  +R+      R +EE       + RE E Q  R+AEE  LR         
Sbjct: 569 LARRQTIEERKERLESLNIQREKEEL------EQREAELQKVRKAEEERLR--------- 613

Query: 566 RQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSD 622
               +EA+ RE+ ER+ QE E+  ++  +ERLE+ K+ E   K  +  +  D +  D
Sbjct: 614 ----QEAKEREK-ERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELD 665



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 10/97 (10%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKE-ERRRAAVE 125
           +RLA ER    E++   R      +EER   +Y +  EE ++R EEQ  KE E R  A  
Sbjct: 781 ERLAEERHNRLEERKRQR------KEERRITYYREKEEEEQRRAEEQMLKEREERERAER 834

Query: 126 EKRRQRLEEDKER---HEAVVRRTMERSQKPKQKHNR 159
            KR + L E +ER    E V R+  +R  + +++  R
Sbjct: 835 AKREEELREYQERVKKLEEVERKKRQRELEIEERERR 871



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 36/152 (23%), Positives = 76/152 (50%), Gaps = 18/152 (11%)

Query: 484 AEKRRLAREQREKE-ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
           AE+ RL +E +E+E ER  +E E+++++   E  +++ +     +  +   +E  +  + 
Sbjct: 607 AEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDP 666

Query: 543 EEQLQRQAEERALREREEAERAQRQKE-----EEARVREEAERVRQEREKH-------FQ 590
           +  + +Q E+    ++E  ER + Q++     E A+  EE   ++   E+        ++
Sbjct: 667 DFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWE 726

Query: 591 REEQER-----LERKKRLEEIMKRTRRTEATD 617
           ++E+ER     LER+K LE   + +R  E  D
Sbjct: 727 QQEEERITTMQLEREKALEHKNRMSRMLEDRD 758



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 36/149 (24%), Positives = 71/149 (47%), Gaps = 16/149 (10%)

Query: 486  KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQ 545
            ++  ARE+     RE R  EE E  + +E       +R  +  EE+ + + E+ R++E  
Sbjct: 1180 EKEKAREESWGPPRESRPSEEREWDREKE------RDRDNQDREENDK-DPERERDRERD 1232

Query: 546  LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQER-EKHFQREEQERLERKKRLE 604
            + R  E+R  R R+E    +   EE +  R+ + R  ++R ++  +R+++  L  ++ L 
Sbjct: 1233 VDR--EDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLR 1290

Query: 605  EIMK------RTRRTEATDKKTSDQRNGD 627
            +         R+ R E +  + +D R  D
Sbjct: 1291 DDRDRRGPPLRSEREEVSSWRRADDRKDD 1319



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 34/105 (32%), Positives = 52/105 (49%), Gaps = 11/105 (10%)

Query: 540 REKEEQLQRQAEERALREREEAER--AQRQKEEEARVREEAERVRQEREKHFQRE----- 592
           +EKEEQ Q          R+E +R  A+RQ  EE + R E+  +++E+E+  QRE     
Sbjct: 544 QEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQK 603

Query: 593 ----EQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL 633
               E+ERL ++ +  E  +  +  E   KKT  +R   I K  L
Sbjct: 604 VRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTEL 648



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 3/94 (3%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE---RRRA 122
           RQ +  E+ ++ E++LA      LE  +R R+   +    R+K  EEQR+ EE   + R 
Sbjct: 768 RQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKERE 827

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             E   R + EE+   ++  V++  E  +K +Q+
Sbjct: 828 ERERAERAKREEELREYQERVKKLEEVERKKRQR 861



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 11/142 (7%)

Query: 486  KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQ 545
            +R  A E     +  RR+  + + ++RE   +R   ER   R++  RR    ++  +E  
Sbjct: 1249 RRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVS 1308

Query: 546  LQRQAEER---ALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKR 602
              R+A++R    + ER+   R         R R+       E+EK   R E++R      
Sbjct: 1309 SWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDR------ 1362

Query: 603  LEEIMKRTRRTEATDKKTSDQR 624
              E ++RT+     D  T+ +R
Sbjct: 1363 --ESLRRTKNETDEDGWTTVRR 1382



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 27/96 (28%), Positives = 52/96 (54%), Gaps = 9/96 (9%)

Query: 70  ARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK--EERRRAAVEEK 127
           A E +    + L  R++  +  +   +  YE+ L++ ++RL E+R    EER+R   EE+
Sbjct: 743 ALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEER 802

Query: 128 R----RQRLEEDKERHEAVV---RRTMERSQKPKQK 156
           R    R++ EE++ R E  +   R   ER+++ K++
Sbjct: 803 RITYYREKEEEEQRRAEEQMLKEREERERAERAKRE 838



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 29/91 (31%), Positives = 50/91 (54%), Gaps = 7/91 (7%)

Query: 73  RREEREKQLAAREIVWLEREERARQHYEKH-LEERKKRLEE---QRQKEERRRAAVEEKR 128
           + +E + QLA    +   R+E  R    +  +EERK+RLE    QR+KEE  +   E ++
Sbjct: 544 QEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQK 603

Query: 129 RQRLEEDKERHEAVVR---RTMERSQKPKQK 156
            ++ EE++ R EA  R   R ++  ++ K+K
Sbjct: 604 VRKAEEERLRQEAKEREKERILQEHEQIKKK 634



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 7/78 (8%)

Query: 82  AAREIVWLER----EERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKE 137
           AAR+ V+ E+    EER  +     LEERK++ +E+R+    R    EE+RR   +  KE
Sbjct: 766 AARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKE 825

Query: 138 RHEAVVRRTMERSQKPKQ 155
           R E   R   ER+++ ++
Sbjct: 826 REE---RERAERAKREEE 840



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)

Query: 484  AEKRRLAREQ---REKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
            +E+R   RE+   R+ ++RE  +++    + RE    R    R  R E   RR  AE++ 
Sbjct: 1198 SEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESS 1257

Query: 541  EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER----VRQEREK 587
               +  +R   +R  R RE  +R  R   E   +R++ +R    +R ERE+
Sbjct: 1258 SWRDSSRRDDRDRDDRRRERDDR--RDLRERRDLRDDRDRRGPPLRSEREE 1306



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 27/94 (28%), Positives = 54/94 (57%), Gaps = 13/94 (13%)

Query: 62  RVDDRQRLARERR-EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ-KEER 119
           R + ++ LAR +  EER+++L +  I          Q  ++ LE+R+  L++ R+ +EER
Sbjct: 562 RKEHQRILARRQTIEERKERLESLNI----------QREKEELEQREAELQKVRKAEEER 611

Query: 120 RRAAVEEKRRQR-LEEDKERHEAVVRRTMERSQK 152
            R   +E+ ++R L+E ++  +  VR  +E+ +K
Sbjct: 612 LRQEAKEREKERILQEHEQIKKKTVRERLEQIKK 645



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 35/148 (23%), Positives = 59/148 (39%), Gaps = 19/148 (12%)

Query: 484  AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKE 543
            A+  R+ R   E +    R  ++      + L++R  ++R  RR ++SR           
Sbjct: 1123 ADDDRIPRRGAEDDRGPWRNMDD------DRLSRRADDDRFPRRGDDSR----------P 1166

Query: 544  EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
               +   +    RE+E+A         E+R  EE E    +REK   R+ Q+R E  K  
Sbjct: 1167 GPWRPLVKPGGWREKEKAREESWGPPRESRPSEERE---WDREKERDRDNQDREENDKDP 1223

Query: 604  EEIMKRTRRTEATDKKTSDQRNGDIAKG 631
            E    R R  +  D+    +  G   +G
Sbjct: 1224 ERERDRERDVDREDRFRRPRDEGGWRRG 1251



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 34/127 (26%), Positives = 54/127 (42%), Gaps = 17/127 (13%)

Query: 39   PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREE----- 93
            PA   S   ++   +  D     R  D +R  RERR+ R+ +      +  EREE     
Sbjct: 1252 PAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWR 1311

Query: 94   RARQHYEKHLEERKK-------RLEEQRQKE-ERRRAAVEEKRRQRLEEDKERHEAVVRR 145
            RA    +  +EER          L   R+++ +R R   +EK   R E+D+E     +RR
Sbjct: 1312 RADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRES----LRR 1367

Query: 146  TMERSQK 152
            T   + +
Sbjct: 1368 TKNETDE 1374


>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
           [Homo sapiens]
          Length = 918

 Score = 80.5 bits (197), Expect = 5e-15
 Identities = 56/167 (33%), Positives = 96/167 (57%), Gaps = 14/167 (8%)

Query: 465 ASVKTSAGTTDPEEATRLLAEK-RRLAREQREKEER------ERREQEELERQKREELAQ 517
           A  K +A   +  EA R   E+ RRL   Q+E+EER      +++++EE ER ++   A+
Sbjct: 623 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK 682

Query: 518 RVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE---EAERAQRQK---EEE 571
           R+AE+R   R E+ RR +  + +E+ EQ +R+ +ER L E+E   E ER Q ++   E E
Sbjct: 683 RLAEQREQERREQERREQERREQERREQ-ERREQERQLAEQERRREQERLQAERELQERE 741

Query: 572 ARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDK 618
             +R + E++++E E+  ++EEQ+RL  ++  EE  K+ +      K
Sbjct: 742 KALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 65/186 (34%), Positives = 95/186 (51%), Gaps = 19/186 (10%)

Query: 477 EEATRLLAEKRRLAREQREKEERERRE----QEELERQKREELAQRVAEE--RTTRREEE 530
           E+A +  A K+    E R K+E E R     Q+E E ++ +EL Q+  EE     R+  E
Sbjct: 621 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE 680

Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQ-RQKEEEARVRE----EAERVRQER 585
           ++RL  ++ +E+ EQ +R+ E R    RE+  R Q RQ  E+ R RE    +AER  QER
Sbjct: 681 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 740

Query: 586 EK--HFQREE-QERLERKKRLEEIMKRTRR--TEATDKKTSDQRNGDIAKGALTGGTEVS 640
           EK    Q+E+ Q  LE KK+ EE  +   R   E  +KK  +      A  AL    +V 
Sbjct: 741 EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAG---ASKALNVTVDVQ 797

Query: 641 ALPCTT 646
           +  CT+
Sbjct: 798 SPACTS 803



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 51/155 (32%), Positives = 93/155 (60%), Gaps = 17/155 (10%)

Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR---LEAEQAR 540
           A++ RLA E+ +K+   ++ +E   R+K+EE A+R+   R  ++EEE RR   L  ++  
Sbjct: 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL---RWLQQEEEERRHQELLQKKKE 669

Query: 541 EKEEQLQRQAEERALRE-REEAERAQRQKEEEARVREEAERVRQEREKHF----QREEQE 595
           E++E+L++ AE + L E RE+  R Q ++E+E R +E  E+ R+E+E+      +R EQE
Sbjct: 670 EEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 729

Query: 596 RLERKKRLEE------IMKRTRRTEATDKKTSDQR 624
           RL+ ++ L+E      + K   + E  +KK  +++
Sbjct: 730 RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 86/333 (25%), Positives = 135/333 (40%), Gaps = 51/333 (15%)

Query: 314 VSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVK 373
           V+ + P+  +   +  W P         TP P         K A +    PS G     +
Sbjct: 385 VAAAEPEVPENNGNNSW-PHNDTEIANSTPNP---------KPAASSPETPSAG-----Q 429

Query: 374 REVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAP 433
           +E K + +   P + PQ    + S K     +  E+   +E         P++P     P
Sbjct: 430 QEAKTD-QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPC----P 484

Query: 434 ASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ 493
           AS            V    M+  P+S   +         T    +      EK R    Q
Sbjct: 485 ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKER----Q 540

Query: 494 REKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQ---- 549
           R +  R + E E+L RQK EE  +R  EE   +REE  R++   QARE+ EQ++ +    
Sbjct: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV--LQARERVEQMKEEKKKQ 598

Query: 550 --------------AEERALREREEAERAQRQKEEEARVR----EEAERVRQEREKHFQR 591
                         A+E  L E +  ++A  +K EE   R    EEA R+R  +++  +R
Sbjct: 599 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 658

Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
             QE L++KK  EE  +R R+  A  K+ ++QR
Sbjct: 659 RHQELLQKKK--EEEQERLRKA-AEAKRLAEQR 688



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 53/168 (31%), Positives = 95/168 (56%), Gaps = 22/168 (13%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQ-EELERQKREELAQRVAE--ERTTRREEESRR 533
           EE  R   E+ +L RE+R ++  + RE+ E+++ +K++++ Q+ A+  E+T + +EE  R
Sbjct: 560 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE--R 617

Query: 534 LEAEQAREK-------EEQLQRQAEERALR---------EREEAERAQRQKEEE-ARVRE 576
           L  E+A++K       E + +R+ EE A R         ER   E  Q++KEEE  R+R+
Sbjct: 618 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 677

Query: 577 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            AE  R   ++  +R EQER E+++R +E  ++ RR +       ++R
Sbjct: 678 AAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 725



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 49/159 (30%), Positives = 88/159 (55%), Gaps = 16/159 (10%)

Query: 478 EATRLLAEKRRLAREQR-----EKEERERREQEELERQKREELAQRVAEERTTRRE-EES 531
           E    + E+++   EQ+     EK E+ + E+   E+ K++  A+++ E    R++ EE+
Sbjct: 586 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645

Query: 532 RRL----EAEQAREKEEQLQRQAEE--RALREREEAERAQRQKEEEARVREEAERVRQER 585
           RRL    + E+ R  +E LQ++ EE    LR+  EA+R   Q+E+E R +E  E+ R+E+
Sbjct: 646 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 705

Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           E    R EQER E++++L E  +R  +     ++   +R
Sbjct: 706 E----RREQERREQERQLAEQERRREQERLQAERELQER 740



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 31/109 (28%), Positives = 61/109 (55%), Gaps = 2/109 (1%)

Query: 464 SASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER 523
           +A  K  A   + E   +   E+ R  +E+RE+E RE  ++ +L  Q+R    +R+  ER
Sbjct: 678 AAEAKRLAEQREQERREQERREQERREQERREQERRE--QERQLAEQERRREQERLQAER 735

Query: 524 TTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEA 572
             +  E++ RL+ EQ + + E+ +++ E++ L ER+  E  +++ +E A
Sbjct: 736 ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 139/642 (21%), Positives = 241/642 (37%), Gaps = 132/642 (20%)

Query: 84  REIVWLE--REERAR---QHYEKHLEERKKRLEEQRQKEERRRAAVEEKRR----QRLEE 134
           +++VWLE  +EE  R   + + K  E   K   ++ ++++RR + V+++ R    +RL  
Sbjct: 29  KDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSR 88

Query: 135 DKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPV 194
            K R   +  R +      ++        GS+    +  +A     + +TM L+    P 
Sbjct: 89  RKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAA---AAAAATMALAAPSSPT 145

Query: 195 ISKRLSSSSATLLNSP-DRARRLQLSP-------------------WESSVVNRLLTPTH 234
                  S   L   P D   + QL P                     +  + R L+PT 
Sbjct: 146 -----PESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTP 200

Query: 235 SFLARSKSTAALSGEAASCSPIIMPYKA-AHSRNSMDRPKLFVTP--PEGSSRRRIIHGT 291
           +      +TA  S    +      P K+ A    S+    L  TP  P+G        GT
Sbjct: 201 A-----SATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGV-----GT 250

Query: 292 ASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPP 351
               +   +  +  ++ G R   SP+ P +  P R R+  P   LP    TP   S    
Sbjct: 251 G---RSASKLRIAQVSPGPRD--SPAFPDS--PWRERVLAPI--LPDNFSTPTG-SRTDS 300

Query: 352 GSVKAAPAQVRPPSPGNIRPVKREVKVEPE---KKDPEKEPQKVANEPSLKGRA------ 402
            SV+ +P     PSP  +   K  +  + E   ++   +  +K A EP+  GR       
Sbjct: 301 QSVRHSPIAPSSPSP-QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYL 359

Query: 403 -PLVKVE---EATVEERTPAEPEVGPAAPAMAPAPASA--------PAPASAPAPAPVPT 450
             L+ VE   +   E++ P E E  P A A    P +             +   P P P 
Sbjct: 360 ERLLNVEVPQKVGSEQKEPPE-EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418

Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELER- 509
            +    PS+     A    + G  +P ++ R    KR   +   E +E +  E EEL+  
Sbjct: 419 ASSPETPSAG-QQEAKTDQADGPREPPQSAR---RKRSYKQAVSELDEEQHLEDEELQPP 474

Query: 510 -------------------------QKREELAQRVAEERTTRR----------------- 527
                                    Q+ + L    +  R+  +                 
Sbjct: 475 RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSF 534

Query: 528 -EEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQERE 586
            E+E +RLE  + +E+ EQL+RQ  E   R R E  + +R+ E   +V +  ERV Q +E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE-ERLRKVLQARERVEQMKE 593

Query: 587 KHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDI 628
           +  ++ EQ+  +  ++ E+  +     E   KK + ++  ++
Sbjct: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 635



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 23/117 (19%)

Query: 66  RQRLARERREE----REKQLAAREIVWLEREERARQHYE---KHLEERK---------KR 109
           +++ A ++ EE    R+++  AR + WL++EE  R+H E   K  EE +         KR
Sbjct: 624 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR 683

Query: 110 LEEQRQKEERRRAAVEEKRR-------QRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           L EQR++E R +   E++RR       +R E++++  E   RR  ER Q  ++   R
Sbjct: 684 LAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 740



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 46/169 (27%), Positives = 75/169 (44%), Gaps = 48/169 (28%)

Query: 36  SSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREI--------- 86
           +S P S +      ++  + DP       +RQRL   RR+E  +QL  +++         
Sbjct: 509 TSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLE 568

Query: 87  -VWLEREER------ARQHYEKHLEERKKRLEE---------QRQKEER----------- 119
            V L+REER      AR+  E+  EE+KK++E+         ++ KEER           
Sbjct: 569 EVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 628

Query: 120 ---------RRAAVEEKRRQRL---EEDKERHEAVVRRTMERSQKPKQK 156
                    RR   EE RR R    EE++ RH+ ++++  E  Q+  +K
Sbjct: 629 AKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 677



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 29/102 (28%), Positives = 59/102 (57%), Gaps = 4/102 (3%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA- 123
           +++R  +ERRE+  ++   RE    ER E+ RQ  E+     ++RL+ +R+ +ER +A  
Sbjct: 689 EQERREQERREQERREQERRE---QERREQERQLAEQERRREQERLQAERELQEREKALR 745

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGS 165
           +++++ QR  E+K++ E   R    + Q+ ++K  + + G S
Sbjct: 746 LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 787



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 26/95 (27%), Positives = 52/95 (54%), Gaps = 12/95 (12%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERK---KRLEEQRQKEERRR 121
           + +RLA +R +ER +Q         ER E+ R+  E+  +ER+   ++L EQ ++ E+ R
Sbjct: 680 EAKRLAEQREQERREQ---------ERREQERREQERREQERREQERQLAEQERRREQER 730

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
              E + ++R +  + + E + R   E+ +K +Q+
Sbjct: 731 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 24/88 (27%), Positives = 48/88 (54%), Gaps = 2/88 (2%)

Query: 67  QRLARERREEREKQL--AAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           Q L ++++EE +++L  AA      E+ E+ R+  E+  +ER+++   ++++ E+ R   
Sbjct: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQK 152
           E++RR+  E  +   E   R    R QK
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQK 748



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 2/68 (2%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERA-RQHYEKHLEERKKRLEEQRQKEERR 120
           R  +RQ   +ERR E+E+  A RE+   E+  R  ++  ++ LEE+KK+ EEQ++  ER+
Sbjct: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK-EEQQRLAERQ 771

Query: 121 RAAVEEKR 128
               +EK+
Sbjct: 772 LQEEQEKK 779


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 121/573 (21%), Positives = 234/573 (40%), Gaps = 48/573 (8%)

Query: 73  RREEREK--QLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
           + EE+ K  + + +E V +E +    Q  E+  EE +K  +E+  KEE      EE+  +
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE---GGEEEEAE 495

Query: 131 RLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHG------SPSIHSADPDRRSVST 184
             EE+ +   A    + E+  K   K    S   +         SP+   +    +S + 
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555

Query: 185 MNLSKYVDPVISKRLSSSSATLLNSPDRAR----RLQLSPWESSVVNRLLTPT-HSFLAR 239
                  +    ++  + S   + SP++A+        SP E+    +  +P      + 
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615

Query: 240 SKSTAALSGEAASCSPIIMPYKA-AHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKER 298
           +++ + +  EA S + +  P KA + ++     P+   +P +  ++            E+
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAK----------SPEK 665

Query: 299 ERENVLFLTSGTRRAVSPSNPKARQP--ARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKA 356
            +  V        +A SP   +A+ P  A+S +   +KS P    +P    +  P   K+
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS-PEKAKSPVKEEAKSPEKAKS 724

Query: 357 APAQVRPPSPGNIR-PVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEER 415
            P +    +P   + PVK E K   + K PEK        P  K  A   K E  +  ++
Sbjct: 725 -PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA---KEEARSPADK 780

Query: 416 TPAEPEVGPAAPAMAPAPASAPAPASAPAPAP-VPTPAMVSAPSSTVNASASVKTSAGTT 474
            P + +        +P  A +P    A AP   +P    V +P         VK      
Sbjct: 781 FPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK 840

Query: 475 DPEE----ATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEE 530
             EE    AT    EK+   +E+  K+E  + + EE    K+E   ++  E +   ++EE
Sbjct: 841 KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE----KKEPAVEKPKESKVEAKKEE 896

Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
           +   +     EKE   + + +E A + +E+ E A+++  ++A+ +E ++   ++     +
Sbjct: 897 AEDKKKVPTPEKEAPAKVEVKEDA-KPKEKTEVAKKE-PDDAKAKEPSKPAEKKEAAPEK 954

Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           ++ +E  E+ K+ EE  K   + +  DK  S +
Sbjct: 955 KDTKE--EKAKKPEEKPKTEAKAKEDDKTLSKE 985



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 115/533 (21%), Positives = 201/533 (37%), Gaps = 42/533 (7%)

Query: 116 KEERRRAAVEEKRRQRL--EEDKERHEAVVRRTMERSQKPKQKHNRWSWGGS---LHGSP 170
           K E +   VE+  ++ +  EE  E  +     T E  ++ K++  +   GG      G  
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498

Query: 171 SIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLL 230
               + P   + S    +K   PV  +  S + A    SP++      SP E     +  
Sbjct: 499 EETKSPPAEEAASPEKEAK--SPVKEEAKSPAEA---KSPEKEEAK--SPAEVKSPEKAK 551

Query: 231 TPT-HSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIH 289
           +P      +  ++ +    EA S + +  P KA        +     +P E  S  +   
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK-----SPAEAKSPEK--- 603

Query: 290 GTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSL 349
              S  KE  +      +     A SP+  K+ + A+S     +KS P    +P    + 
Sbjct: 604 -AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS-PEKAKSPEKEEAK 661

Query: 350 PPGSVKAAPAQVRPPSPGNIR-PVKREVK--------VEPEKKDPEKEPQKVANEPSLKG 400
            P   K+ P +    SP   + PVK E K        V+ E K PEK    V  E     
Sbjct: 662 SPEKAKS-PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720

Query: 401 RAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSST 460
           +A     EEA   E+  +  +    +P  A +P  A         A  P      +P+  
Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780

Query: 461 VNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ-KREELAQRV 519
               A          PE+A   L       +E  +  E+E  ++EE++   K EE  Q V
Sbjct: 781 FPEKAKSPVKEEVKSPEKAKSPL-------KEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833

Query: 520 AEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE 579
             +   ++ EE +     +  EK++  + +A ++   + +  E+ +   E+    + EA+
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893

Query: 580 RVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGA 632
           +   E +K     E+E    K  ++E  K   +TE   K+  D +  + +K A
Sbjct: 894 KEEAEDKKKVPTPEKE-APAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 117/571 (20%), Positives = 209/571 (36%), Gaps = 48/571 (8%)

Query: 65   DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR-LEEQRQKEERRRAA 123
            +  ++  E  EE EK+  A+E    E E    +  E   EE K    EE    E+  ++ 
Sbjct: 462  EETQVTEEVTEEEEKE--AKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP 519

Query: 124  VEEKRRQRLE-EDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSV 182
            V+E+ +   E +  E+ EA     ++  +K K      +       SP    A       
Sbjct: 520  VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK 579

Query: 183  STMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKS 242
            S                 + S     SP +      +  +S V     +P     +  K+
Sbjct: 580  SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE-VKSPEKA 638

Query: 243  TAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKK-ERERE 301
             +    EA S      P K      S ++ K  V     S  +      A  K  E+ + 
Sbjct: 639  KSPTKEEAKSPEKAKSPEK--EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKS 696

Query: 302  NVLFLTSGTRRAVSP------SNPKARQPARSRLWLPSKSL---------PHLPGTPRPT 346
             V        +A SP      S  KA+ P +     P K+          P    +P   
Sbjct: 697  PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA 756

Query: 347  SSLPPGSVKA-APAQVRPPSPGNIRPVKREVKVEPEKKDPEK--EPQKVANEPSLKGRAP 403
             +L   S +A  PA+    SP +  P K +  V+ E K PEK   P K   +   K    
Sbjct: 757  KTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816

Query: 404  LVKVEEATVEERTPAEPEVGP----AAPAMAPA-PASAPAPASAPAPAP---VPTPAMVS 455
              +V+    EE  P E +V      A    APA P +     S    AP    P P +  
Sbjct: 817  KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876

Query: 456  APSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREEL 515
                 V      K  A   + E+  ++   ++    +   KE+ + +E+ E+ +++ ++ 
Sbjct: 877  KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDD- 935

Query: 516  AQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVR 575
                      + +E S+  E ++A  +++  +   EE+A +  E+ +   + KE++  + 
Sbjct: 936  ---------AKAKEPSKPAEKKEAAPEKKDTK---EEKAKKPEEKPKTEAKAKEDDKTLS 983

Query: 576  EEAERVRQER-EKHFQREEQERLERKKRLEE 605
            +E  + + E+ EK    ++++    +K  E+
Sbjct: 984  KEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 52/256 (20%), Positives = 97/256 (37%), Gaps = 25/256 (9%)

Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREK 496
           P P S P   P         PS + +     +      +  E   ++ E++     Q  +
Sbjct: 417 PIPFSLPEGLP-------KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQT-EETQVTE 468

Query: 497 EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALR 556
           E  E  E+E  E + +EE  +   EE     EEE++   AE+A   E++ +   +E A  
Sbjct: 469 EVTEEEEKEAKEEEGKEE--EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS 526

Query: 557 -------EREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKR 609
                  E+EEA+     K  E       E  +   E     +E+ +   + +  E  K 
Sbjct: 527 PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS 586

Query: 610 TRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVT 669
             + EA  K  ++ ++ + AK  +    E +  P    +P   +      V +  ++K  
Sbjct: 587 PAKEEA--KSPAEAKSPEKAKSPV---KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641

Query: 670 VE---STPDLEKQPNE 682
            +    +P+  K P +
Sbjct: 642 TKEEAKSPEKAKSPEK 657



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 36/178 (20%), Positives = 75/178 (42%), Gaps = 12/178 (6%)

Query: 18   VRSETAPDSYKVQDK-KNASSRPASAISGQNNNHSGNKPDPP----PVLRVDDRQRLARE 72
            V+ E  P   KV++  K A    A A           K + P    P  +V++++  A E
Sbjct: 824  VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883

Query: 73   RREE------REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
            + +E      +E+    +++   E+E  A+   ++  + ++K  E  +++ +  +A    
Sbjct: 884  KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT-EVAKKEPDDAKAKEPS 942

Query: 127  KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVST 184
            K  ++ E   E+ +    +  +  +KPK +        +L   PS   A+   +S ST
Sbjct: 943  KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 30/129 (23%), Positives = 57/129 (44%), Gaps = 28/129 (21%)

Query: 508 ERQKREELAQRVAE--ERTTRREEESRRLEAEQAREKEEQLQRQAE----ERALRER--- 558
           E+++ + L  R A   ++  + E  +R LE E A  +++Q  R A     ER +RE    
Sbjct: 97  EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGA 156

Query: 559 -------------------EEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
                              E+    +++ ++EAR REEAE   +   +  Q  E  R++ 
Sbjct: 157 VLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDL 216

Query: 600 KKRLEEIMK 608
           +K+ + + +
Sbjct: 217 QKKAQALQE 225



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 36/115 (31%), Positives = 53/115 (46%), Gaps = 10/115 (8%)

Query: 487 RRLAREQREKE-ERERREQEELERQKREELAQRVAEER--TTRREEESR---RLEAEQAR 540
           R+L    R  E E     Q++  R    EL +R   E      R   +R   RLE E   
Sbjct: 116 RQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLL 175

Query: 541 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
           E    ++++ ++ A R+REEAE A R     AR  +EAE  R + +K  Q  ++E
Sbjct: 176 EDIAHVRQRLDDEA-RQREEAEAAARAL---ARFAQEAEAARVDLQKKAQALQEE 226



 Score = 33.5 bits (75), Expect = 0.74
 Identities = 45/176 (25%), Positives = 70/176 (39%), Gaps = 40/176 (22%)

Query: 486 KRRLAREQREKEERE-----------RREQEELERQKREELAQRVAEERTTRREEESRRL 534
           ++RL  E R++EE E             E   ++ QK+ +  Q          +EE   L
Sbjct: 182 RQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGEL 241

Query: 535 EAEQAREKEEQLQRQAEER---------ALRE---------------REEAERAQRQK-E 569
             +       Q Q QAE R         ALRE                EE  R +  +  
Sbjct: 242 LGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLS 301

Query: 570 EEARVREEAERVRQEREKHFQREEQER---LERKKRLEEIMKRTRRTEATDKKTSD 622
           E A+V  +A R  QE    ++R+ Q R   LE  K  ++ ++R +R+E  D+  +D
Sbjct: 302 EAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLER-QRSELEDRHQAD 356


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 79.7 bits (195), Expect = 9e-15
 Identities = 50/145 (34%), Positives = 77/145 (53%), Gaps = 9/145 (6%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
           E+RR+ R    ++ER R    E ER +  E   R  E    R  E+ R LE E+ARE+E 
Sbjct: 661 EERRVDRVDDRRDERARERDRERERDRERE---RERERERDREREKERELERERARERER 717

Query: 545 QLQRQAEERALRERE-----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
           + +++ +    R+R+     E ER + +++E  R REE ER R ERE+  +RE +   ER
Sbjct: 718 EREKERDRERDRDRDHDRERERERERDREKEREREREERERER-ERERERERERERERER 776

Query: 600 KKRLEEIMKRTRRTEATDKKTSDQR 624
            +  ++  +R R  E  DK   D+R
Sbjct: 777 ARERDKERERQRDWEDKDKGRDDRR 801



 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 49/154 (31%), Positives = 83/154 (53%), Gaps = 7/154 (4%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           +E  R    +R   RE+  + ERER  + E ER+   E A+    ER   R+ E  R + 
Sbjct: 673 DERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDR-DR 731

Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE-EAERVRQ-----EREKHFQ 590
           +  RE+E + +R  E+   REREE ER + ++ E  R RE E ER R+     ER++ ++
Sbjct: 732 DHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWE 791

Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            +++ R +R+++ EEI +     +  D++ S +R
Sbjct: 792 DKDKGRDDRREKREEIREDRNPRDGHDERKSKKR 825



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 43/142 (30%), Positives = 66/142 (46%), Gaps = 9/142 (6%)

Query: 478 EATRLLAEKRRLAREQREKEERER-----REQEELERQKREELAQRVAEERTTRREEESR 532
           E  R  A +R   RE+    ER+R     RE+E    + RE+  +R  EER   RE E  
Sbjct: 706 ELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERE 765

Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
           R E E+ RE+E   +R  E    R+ E+ ++ +  + E+   REE    R  R+ H +R+
Sbjct: 766 R-ERERERERERARERDKERERQRDWEDKDKGRDDRREK---REEIREDRNPRDGHDERK 821

Query: 593 EQERLERKKRLEEIMKRTRRTE 614
            ++R   +          RR E
Sbjct: 822 SKKRYRNEGSPSPRQSPKRRRE 843



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 131/606 (21%), Positives = 219/606 (36%), Gaps = 86/606 (14%)

Query: 62   RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
            R  DR+R  RER  +REK+            ER R+  E+  E  ++R  E+ ++ ER R
Sbjct: 731  RDHDRER-ERERERDREKE-----------REREREERERERERERERERERERERERAR 778

Query: 122  AAVEEKRRQRLEEDKER---HEAVVRRTMERSQKPKQKHNRWSWGGSL--HGSPS----- 171
               +E+ RQR  EDK++        R  +   + P+  H+           GSPS     
Sbjct: 779  ERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSP 838

Query: 172  ----IHSADPDR------RSVSTMNLSKYVDPVISKRLSSSSATLLNS---PDRARRLQL 218
                 HS D D       ++     LS+ V P  S+ LS S  T        +  R+ + 
Sbjct: 839  KRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPER 898

Query: 219  SPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTP 278
                     + L    S + + +    +   +   +  I+ +  +  R + DR       
Sbjct: 899  KESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR-----AH 953

Query: 279  PEGSSRRRIIHGTASYKKER----ERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSK 334
             E   + +I       KKE     ER N+   TS   +  SP   + +           K
Sbjct: 954  DENKKKAKIQKKPIKKKKEDDVGIERGNI-ETTSEDGQVFSPKKGQKK-----------K 1001

Query: 335  SLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVAN 394
            S+       +  S +          + R P    I   +  V++   K    ++ QK   
Sbjct: 1002 SIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQK--- 1058

Query: 395  EPSLKGRAPLVKVEEATVEERTPAEPEVGPAA-PAMAPAPASAPAPASA--PAPAPVPTP 451
                K         +  V +RT    EV  A   A A  P S P+P S+  P P PV T 
Sbjct: 1059 ----KEDTAFSDWSDEDVPDRT----EVTEAEHTATATTPGSTPSPLSSLLPPPPPVATA 1110

Query: 452  AMVSAPSSTVNASASVKTSAGT---TDPEEATRLLAEKRRLAREQREKE-ERERREQEEL 507
               + P++    +A+  TS  T   T    AT         A E   ++  R R E+ E 
Sbjct: 1111 TATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVET 1170

Query: 508  ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE--QLQRQAEERALREREEAERAQ 565
                 E+     A+ R    ++ S  L + ++       +L+  + + A R  ++    +
Sbjct: 1171 PHVTIED-----AQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRK 1225

Query: 566  RQKEEEARVREEAERV-----RQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKT 620
            R     +R RE+ + +     R+ R    +R E  R     R +     +RR+     + 
Sbjct: 1226 RVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQ 1285

Query: 621  SDQRNG 626
               R+G
Sbjct: 1286 VHSRSG 1291



 Score = 50.4 bits (119), Expect = 6e-06
 Identities = 43/177 (24%), Positives = 82/177 (46%), Gaps = 11/177 (6%)

Query: 470  SAGTTDPEEATRLLAEKRRLAREQREKEER----ERREQEELERQKREELAQRVAEERTT 525
            S  T+   + +R  + +R      R+   R    + R++ + ER + E   +R  E R T
Sbjct: 1260 SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ-ERDRYEHDRERERERRDT 1318

Query: 526  RREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR-QE 584
            R+ E  R  + +  R ++    R+ E    RERE  +R    +E E  + +  ER R ++
Sbjct: 1319 RQREWDRDADKDWPRNRDRDRLRERE----RERERDKRRDLDRERERLISDSVERDRDRD 1374

Query: 585  REKHFQREEQERLER-KKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVS 640
            R++ F+  + E ++R + +LE   +R   + + D    D+   D   G++ G  E +
Sbjct: 1375 RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETN 1431



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 42/160 (26%), Positives = 61/160 (38%), Gaps = 30/160 (18%)

Query: 30  QDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVD-------------DRQR---LARER 73
           +D +    RP+S I  Q  N    + +     RVD             DR+R     RER
Sbjct: 632 RDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERER 691

Query: 74  REEREKQLAAREIVWLERE-------------ERARQHYEKHLEERKKRLEEQRQKEERR 120
             ERE+     +   LERE             +R R     H  ER++  E  R+KE  R
Sbjct: 692 ERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERER 751

Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
                E+ R+R E ++ER     R       K +++   W
Sbjct: 752 EREERERERER-ERERERERERERERARERDKERERQRDW 790



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 35/125 (28%), Positives = 53/125 (42%), Gaps = 1/125 (0%)

Query: 491 REQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQA 550
           R+Q      ERR  E   R  RE   +  +  R   R +E  R E  + R  +    R+ 
Sbjct: 614 RDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRD 673

Query: 551 EERALREREEAERAQRQKEEEARVREEAERVRQ-EREKHFQREEQERLERKKRLEEIMKR 609
           E    R+RE     +R++E E     E E+ R+ ERE+  +RE +   ER +  +     
Sbjct: 674 ERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDH 733

Query: 610 TRRTE 614
            R  E
Sbjct: 734 DRERE 738



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 5/133 (3%)

Query: 498 ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRE 557
           ER+R  + +   Q R+   +R   ER  R   E  +  +   R +    + + +ER  RE
Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDER--RE 661

Query: 558 REEAERAQRQKEEEARVRE-EAERVRQ-EREKHFQREEQERLERKKRLEEIMKRTR-RTE 614
               +R   +++E AR R+ E ER R+ ERE+  +R+ +   ER+   E   +R R R +
Sbjct: 662 ERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREK 721

Query: 615 ATDKKTSDQRNGD 627
             D++    R+ D
Sbjct: 722 ERDRERDRDRDHD 734



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 78/400 (19%), Positives = 141/400 (35%), Gaps = 28/400 (7%)

Query: 311 RRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPT-SSLPPGSVKAAPAQVRPPSPGNI 369
           R+  + S+P   Q   S+     K  P  P  P P    +  G       +V+       
Sbjct: 235 RKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKT 294

Query: 370 RPVK---REVKVEPEKKDPEKEPQKVA----------NEPSLKGRAPLVKVEEATVEERT 416
           R  K   R+ + + EK+D  +                +  S +  + + +   +   +RT
Sbjct: 295 RDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRT 354

Query: 417 PAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDP 476
           P+        P +  + +  P+  S  +P    +P    +P          +TS      
Sbjct: 355 PSPSYQRTLTPPLRRSASPYPSH-SLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRR 413

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
            E       KR      REK+ RE RE E+ +   R+    R   +   RR+    R   
Sbjct: 414 HERREDTRGKR-----DREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRR 468

Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQER 596
           E    ++ +  R+  + +   +E  +    +   +A    + E     R++    EE   
Sbjct: 469 ELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRS 528

Query: 597 LERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVG 656
             R    EE  +   R E+ ++  S+ RN  + +        V  LP   +    G  + 
Sbjct: 529 YGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSR----GRVPELPEKGSRGSRGSQID 584

Query: 657 SPHVVTS--HQSKVTVESTPDLEKQP-NENGVSVQNENFE 693
           S H   S  H S  T  S P+ ++ P  +N    ++ +FE
Sbjct: 585 S-HSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFE 623



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 36/167 (21%), Positives = 74/167 (44%), Gaps = 7/167 (4%)

Query: 455  SAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREE 514
            S+  S+  +   V + +G+ D  +    L E+ R   ++  + ER    Q E +R   ++
Sbjct: 1274 SSRRSSPESDRQVHSRSGSFDSRDR---LQERDRYEHDRERERERRDTRQREWDRDADKD 1330

Query: 515  LAQRVAEERTTRREEESRRLEAEQA-REKEEQLQRQAEERALRERE---EAERAQRQKEE 570
              +    +R   RE E  R +     RE+E  +    E    R+R+   E+ + +  K  
Sbjct: 1331 WPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRC 1390

Query: 571  EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATD 617
            EA++  E ER  +   +     ++ER+++     +  + T ++E T+
Sbjct: 1391 EAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTE 1437



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 57/280 (20%), Positives = 111/280 (39%), Gaps = 46/280 (16%)

Query: 370  RPVKREVKVEPEK---KDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAA 426
            R  +RE + E E+   +D E+E Q+   +   KGR    +  E   E+R P +      +
Sbjct: 764  RERERERERERERARERDKERERQRDWEDKD-KGRDDRREKREEIREDRNPRDGHDERKS 822

Query: 427  PAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEK 486
                    S       P+P   P      +P S    S          D  E  RLL++ 
Sbjct: 823  KKRYRNEGS-------PSPRQSPKRRREHSPDSDAYNSGD--------DKNEKHRLLSQ- 866

Query: 487  RRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQL 546
              + R Q  +        E+ + + +EE       +R   R+E SRR E ++ +EK   +
Sbjct: 867  --VVRPQESRSLSPSHLTEDRQGRWKEE-------DRKPERKESSRRYEEQELKEKVSSV 917

Query: 547  QRQAEERALRE-----------------REEAERAQRQKEEEARVREEAERVRQEREKHF 589
             +Q E+  + E                 RE ++RA  + +++A+++++  + ++E +   
Sbjct: 918  DKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGI 977

Query: 590  QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIA 629
            +R   E      ++    K  ++     K+   + + DI+
Sbjct: 978  ERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDIS 1017



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 16/137 (11%)

Query: 491  REQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR---------E 541
            RE+ +  E     +  +++ KR E ++  + +R   R   SRR   E  R         +
Sbjct: 1235 REKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFD 1294

Query: 542  KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR-----QEREKHFQREEQER 596
              ++LQ +      RERE   R  RQ+E +    ++  R R     +ERE+  +R+++  
Sbjct: 1295 SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRD 1354

Query: 597  L--ERKKRLEEIMKRTR 611
            L  ER++ + + ++R R
Sbjct: 1355 LDRERERLISDSVERDR 1371



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 37/140 (26%), Positives = 65/140 (46%), Gaps = 24/140 (17%)

Query: 19  RSETAPDS--YKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREE 76
           R E +PDS  Y   D KN   R  S +     + S +     P    +DRQ   R + E+
Sbjct: 841 RREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLS-----PSHLTEDRQ--GRWKEED 893

Query: 77  REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDK 136
           R+           ER+E +R++ E+ L+E+   +++QR++ E     + E  R R ++  
Sbjct: 894 RKP----------ERKESSRRYEEQELKEKVSSVDKQREQTE-----ILESSRMRAQDII 938

Query: 137 ERHEAVVRRTMERSQKPKQK 156
             H++  R T +R+    +K
Sbjct: 939 GHHQSEDRETSDRAHDENKK 958



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 25/128 (19%), Positives = 55/128 (42%), Gaps = 6/128 (4%)

Query: 498  ERERREQEEL--ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERAL 555
            +RE+ +  E+  ER+ R +  +R    R+T  + +  R  + +    E   Q  +   + 
Sbjct: 1234 DREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSF 1293

Query: 556  REREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
              R+  +   R + +  R RE     R  R++ + R+  +   R +  + + +R R  E 
Sbjct: 1294 DSRDRLQERDRYEHDRERERER----RDTRQREWDRDADKDWPRNRDRDRLRERERERER 1349

Query: 616  TDKKTSDQ 623
              ++  D+
Sbjct: 1350 DKRRDLDR 1357



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 34/124 (27%), Positives = 62/124 (50%), Gaps = 10/124 (8%)

Query: 30   QDKKNASSRPASAISG-QNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVW 88
            QD ++ SSR +S  S  Q ++ SG+        R+ +R R   +R  ERE+    R+   
Sbjct: 1268 QDSRSHSSRRSSPESDRQVHSRSGSFDSRD---RLQERDRYEHDRERERER----RDTRQ 1320

Query: 89   LEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVR-RTM 147
             E +  A + + ++  +R +  E +R++E  +R  ++ +R + + +  ER     R RT 
Sbjct: 1321 REWDRDADKDWPRN-RDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTF 1379

Query: 148  ERSQ 151
            E SQ
Sbjct: 1380 ESSQ 1383



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 3/94 (3%)

Query: 62   RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
            R D R   +R    E ++Q+ +R   +  R+    +   +H  ER++   + RQ+E  R 
Sbjct: 1267 RQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRD 1326

Query: 122  AAVEEKR---RQRLEEDKERHEAVVRRTMERSQK 152
            A  +  R   R RL E +   E   RR ++R ++
Sbjct: 1327 ADKDWPRNRDRDRLRERERERERDKRRDLDRERE 1360



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 36/146 (24%), Positives = 60/146 (41%), Gaps = 16/146 (10%)

Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
           PE  T  L E+ +  R+  + E ++R  +E     ++E         R   RE+E  ++ 
Sbjct: 78  PERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKES-------SRGRHREKEDIKIT 130

Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
            E+  E EE+     E    R+  +          E  +    E  RQ+ ++   + EQE
Sbjct: 131 KERTPESEEE---NVEWETNRDDSDNGDINYDYVHELSL----EMKRQKIQRELMKLEQE 183

Query: 596 RLERKKRLEEIMKRTRRTEATDKKTS 621
            +E  KR E I+K+    E    K S
Sbjct: 184 NME--KREEIIIKKEVSPEVVRSKLS 207



 Score = 32.0 bits (71), Expect = 2.2
 Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 16/100 (16%)

Query: 71  RERREEREKQLAAREIVWLER--EERARQHYEK--------HLEERKKRLEEQRQKEERR 120
           R+R  ER+ +  AR+  +  R  E   R + E+          + R   LE   ++EERR
Sbjct: 605 RDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERR 664

Query: 121 RAAVEEKRRQRL-EEDKERHEAVVRRTMERSQKPKQKHNR 159
              V+++R +R  E D+ER      R  ER ++ +++ +R
Sbjct: 665 VDRVDDRRDERARERDRER-----ERDRERERERERERDR 699



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 38/195 (19%), Positives = 79/195 (40%), Gaps = 12/195 (6%)

Query: 18  VRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREER 77
           VRS+ +P     +  K+   + +   S  +           P+L   D+QR ++  + ++
Sbjct: 202 VRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLL---DQQRNSKTNQSKK 258

Query: 78  EKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKE 137
           +          +  +    + Y++  + + +  E+ R  ++R R    +  RQR + DK 
Sbjct: 259 KGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGR----DFERQREKRDKP 314

Query: 138 RHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISK 197
           R  +   +    S    + H+  S  GS   S   HS  P R+   + +  + + P + +
Sbjct: 315 RSTSPAGQ--HHSPISSRHHSSSSQSGS---SIQRHSPSPRRKRTPSPSYQRTLTPPLRR 369

Query: 198 RLSSSSATLLNSPDR 212
             S   +  L+SP R
Sbjct: 370 SASPYPSHSLSSPQR 384


>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 3 [Homo sapiens]
          Length = 1212

 Score = 79.3 bits (194), Expect = 1e-14
 Identities = 77/312 (24%), Positives = 132/312 (42%), Gaps = 38/312 (12%)

Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ 510
           P     PSS VN              ++  +   E+    R Q+  +E++ REQEE +RQ
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENK---ERSEALRRQQLLQEQQLREQEEYKRQ 390

Query: 511 KREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE 570
              E  +R+ +++  RR  E ++    +AR ++E+ QR+ E+   R  EE ER  R+KEE
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELER--RRKEE 448

Query: 571 EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
           E R R E E+ R ERE+ + R + E  E ++ LE + ++  + +A      D R      
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLE--EEQRHLEVLQQQLLQEQA--MLLHDHRRPH--- 501

Query: 631 GALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNE 690
                  + S  P       +     +P     ++         D  ++ N +    Q++
Sbjct: 502 ------PQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSK 555

Query: 691 NFEEIINLPIGSKPSRLDVTNSES----------PEIPL-----NPILAFDDEGTLGPLP 735
               ++  P+ S+       NSES          P++P+     +P+L+  D     PL 
Sbjct: 556 QTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRD----SPL- 610

Query: 736 QVDGVQTQQTAE 747
           Q  G Q  Q  +
Sbjct: 611 QGSGQQNSQAGQ 622



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 50/155 (32%), Positives = 82/155 (52%), Gaps = 21/155 (13%)

Query: 488 RLAREQREKEERE------RREQEELERQKREELA-QRVAEERTTRREEESRRLEAEQAR 540
           R  +++ EK+E E        E+EE+  Q+ E  +   V  E T RR+    RL+ E  +
Sbjct: 308 RTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD--FLRLQQEN-K 364

Query: 541 EKEEQLQRQA--EERALREREE------AERAQR---QKEEEARVREEAERVRQEREKHF 589
           E+ E L+RQ   +E+ LRE+EE      AER +R   QKE+  R+ E+  R R+ R +  
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424

Query: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           + + +   E K+RLEE+ +R +  E   +   ++R
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 35/91 (38%), Positives = 54/91 (59%), Gaps = 6/91 (6%)

Query: 66  RQRLA-RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           RQ LA R++R E++K+   R      RE  AR+  E+  E+R++  EE+R+ EE  R   
Sbjct: 389 RQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQER--EQRRREQEEKRRLEELERRRK 446

Query: 125 EEKRRQRLEEDK---ERHEAVVRRTMERSQK 152
           EE+ R+R EE+K   ER +  +RR +E  Q+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 91/374 (24%), Positives = 148/374 (39%), Gaps = 79/374 (21%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKH----LEERKKRLEEQRQ-KEE 118
           + R+RL  ++R ERE   A R+    ERE+R R+  EK     LE R+K  EE+R+ +EE
Sbjct: 404 EQRRRLEEQQRRERE---ARRQ---QEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ--------KPKQKHNRWSWGGSLHGS- 169
           +RR   E++  +R  E+++RH  V+++ + + Q        +P  +H++         S 
Sbjct: 458 KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK 517

Query: 170 PSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWE--SSVVN 227
           PS H+ +P            + +P    R            DR R+   S  E  S    
Sbjct: 518 PSFHAPEP----------KAHYEPADRAR---------EVEDRFRKTNHSSPEAQSKQTG 558

Query: 228 RLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRI 287
           R+L P       S+S +  +G + S  P            ++ RP     P   +SR  +
Sbjct: 559 RVLEPP----VPSRSESFSNGNSESVHP------------ALQRPAEPQVPVRTTSRSPV 602

Query: 288 IHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTS 347
           +    S  +   ++N     +G R + S   P+        LW   + L   PG+   + 
Sbjct: 603 LSRRDSPLQGSGQQN---SQAGQRNSTSSIEPRL-------LWERVEKLVPRPGSGSSSG 652

Query: 348 SLPPGSVKAAPA----------QVRPPSPGNIRPVKR--EVKVEPEKKDPEKEPQKVANE 395
           S   GS   +            +VR  S     P +R      +PE K     P K A E
Sbjct: 653 SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 712

Query: 396 PSLKGRAPLVKVEE 409
             L   A  ++  E
Sbjct: 713 VDLTALAKELRAVE 726



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 32/113 (28%), Positives = 60/113 (53%), Gaps = 9/113 (7%)

Query: 56  DPPPVLRVDDRQRLARE----RREEREKQLAAREIVWLEREE-RARQHYEKHL-EERKKR 109
           +P  ++ V     L R+    ++E +E+  A R    L+ ++ R ++ Y++ L  ER+KR
Sbjct: 339 EPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398

Query: 110 LE---EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           +E   EQR++ E ++    E RRQ+  E + R +   RR  E  ++ K++  R
Sbjct: 399 IEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 8/100 (8%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQ-------HYEKHLEERKKRLEEQRQKEER 119
           Q+  +ER E   +Q   +E    E+EE  RQ         E+  E+R++  E+QR++ E 
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           RR    E+RR R +E+K R E + RR  E  ++ + +  +
Sbjct: 420 RRQQEREQRR-REQEEKRRLEELERRRKEEEERRRAEEEK 458



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 27/135 (20%)

Query: 508 ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE-------- 559
           ERQ R +L   +   R  R E++    E   + E+EE+         + E+E        
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE---------VPEQEGEPSSIVN 345

Query: 560 -----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQE-----RLERKKRLEEIMKR 609
                   R   + ++E + R EA R +Q  ++   RE++E       ER+KR+E+  ++
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQ 405

Query: 610 TRRTEATDKKTSDQR 624
            RR E   ++  + R
Sbjct: 406 RRRLEEQQRREREAR 420


>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 1 [Homo sapiens]
          Length = 1166

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 52/165 (31%), Positives = 86/165 (52%), Gaps = 7/165 (4%)

Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ 510
           P     PSS VN              ++  +   E+    R Q+  +E++ REQEE +RQ
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENK---ERSEALRRQQLLQEQQLREQEEYKRQ 390

Query: 511 KREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE 570
              E  +R+ +++  RR  E ++    +AR ++E+ QR+ E+   R  EE ER  R+KEE
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELER--RRKEE 448

Query: 571 EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
           E R R E E+ R ERE+ + R + E  E ++ LE + ++  + +A
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLE--EEQRHLEVLQQQLLQEQA 491



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 47/139 (33%), Positives = 74/139 (53%), Gaps = 22/139 (15%)

Query: 477 EEATRLLAEKRRLAREQREK----EERERREQEELERQKREELAQRVAEERTTRREEESR 532
           E   +LLAE+++   +Q+E+    EE++RRE+E   +Q+RE+           R +EE R
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQ---------RRREQEEKR 436

Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEAR---------VREEAERVRQ 583
           RLE  + R KEE+ +R+AEE   R   E E  +RQ EEE R         ++E+A  +  
Sbjct: 437 RLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHD 496

Query: 584 EREKHFQREEQERLERKKR 602
            R  H Q  +Q    +++R
Sbjct: 497 HRRPHPQHSQQPPPPQQER 515



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 50/155 (32%), Positives = 82/155 (52%), Gaps = 21/155 (13%)

Query: 488 RLAREQREKEERE------RREQEELERQKREELA-QRVAEERTTRREEESRRLEAEQAR 540
           R  +++ EK+E E        E+EE+  Q+ E  +   V  E T RR+    RL+ E  +
Sbjct: 308 RTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD--FLRLQQEN-K 364

Query: 541 EKEEQLQRQA--EERALREREE------AERAQR---QKEEEARVREEAERVRQEREKHF 589
           E+ E L+RQ   +E+ LRE+EE      AER +R   QKE+  R+ E+  R R+ R +  
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424

Query: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           + + +   E K+RLEE+ +R +  E   +   ++R
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 35/91 (38%), Positives = 54/91 (59%), Gaps = 6/91 (6%)

Query: 66  RQRLA-RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           RQ LA R++R E++K+   R      RE  AR+  E+  E+R++  EE+R+ EE  R   
Sbjct: 389 RQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQER--EQRRREQEEKRRLEELERRRK 446

Query: 125 EEKRRQRLEEDK---ERHEAVVRRTMERSQK 152
           EE+ R+R EE+K   ER +  +RR +E  Q+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 62/213 (29%), Positives = 101/213 (47%), Gaps = 34/213 (15%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKH----LEERKKRLEEQRQ-KEE 118
           + R+RL  ++R ERE   A R+    ERE+R R+  EK     LE R+K  EE+R+ +EE
Sbjct: 404 EQRRRLEEQQRRERE---ARRQ---QEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ--------KPKQKHNRWSWGGSLHGS- 169
           +RR   E++  +R  E+++RH  V+++ + + Q        +P  +H++         S 
Sbjct: 458 KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK 517

Query: 170 PSIHSADP-------DR-RSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPW 221
           PS H+ +P       DR R V     S+   PV+S+R S    +   +    +R      
Sbjct: 518 PSFHAPEPKAHYEPADRAREVPVRTTSR--SPVLSRRDSPLQGSGQQNSQAGQRNS---- 571

Query: 222 ESSVVNRLLTPTHSFLARSKSTAALSGEAASCS 254
            SS+  RLL      L     + + SG + S S
Sbjct: 572 TSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGS 604



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 32/113 (28%), Positives = 60/113 (53%), Gaps = 9/113 (7%)

Query: 56  DPPPVLRVDDRQRLARE----RREEREKQLAAREIVWLEREE-RARQHYEKHL-EERKKR 109
           +P  ++ V     L R+    ++E +E+  A R    L+ ++ R ++ Y++ L  ER+KR
Sbjct: 339 EPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398

Query: 110 LE---EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           +E   EQR++ E ++    E RRQ+  E + R +   RR  E  ++ K++  R
Sbjct: 399 IEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 8/100 (8%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQ-------HYEKHLEERKKRLEEQRQKEER 119
           Q+  +ER E   +Q   +E    E+EE  RQ         E+  E+R++  E+QR++ E 
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           RR    E+RR R +E+K R E + RR  E  ++ + +  +
Sbjct: 420 RRQQEREQRR-REQEEKRRLEELERRRKEEEERRRAEEEK 458



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 27/135 (20%)

Query: 508 ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE-------- 559
           ERQ R +L   +   R  R E++    E   + E+EE+         + E+E        
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE---------VPEQEGEPSSIVN 345

Query: 560 -----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQE-----RLERKKRLEEIMKR 609
                   R   + ++E + R EA R +Q  ++   RE++E       ER+KR+E+  ++
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQ 405

Query: 610 TRRTEATDKKTSDQR 624
            RR E   ++  + R
Sbjct: 406 RRRLEEQQRREREAR 420



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 45/202 (22%), Positives = 77/202 (38%), Gaps = 21/202 (10%)

Query: 477 EEATRLLAEKRRLAREQREK----EERER--REQEELERQKREE------LAQRVAEERT 524
           +E  R L E  R  +E+ E+    EE+ R  REQE + RQ  EE      L Q++ +E+ 
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA 491

Query: 525 TRREEESR-RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ 583
               +  R   +  Q     +Q + +    A   +   E A R +E   R    +  V  
Sbjct: 492 MLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSP-VLS 550

Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALP 643
            R+   Q   Q+  +  +R        R      +K   +     + G+   G++  + P
Sbjct: 551 RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHP 610

Query: 644 CTTNAPG-------NGKPVGSP 658
            + +  G       + K  GSP
Sbjct: 611 GSQSGSGERFRVRSSSKSEGSP 632


>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
           isoform 2 [Homo sapiens]
          Length = 1320

 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 52/165 (31%), Positives = 86/165 (52%), Gaps = 7/165 (4%)

Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ 510
           P     PSS VN              ++  +   E+    R Q+  +E++ REQEE +RQ
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENK---ERSEALRRQQLLQEQQLREQEEYKRQ 390

Query: 511 KREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE 570
              E  +R+ +++  RR  E ++    +AR ++E+ QR+ E+   R  EE ER  R+KEE
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELER--RRKEE 448

Query: 571 EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
           E R R E E+ R ERE+ + R + E  E ++ LE + ++  + +A
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLE--EEQRHLEVLQQQLLQEQA 491



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 42/132 (31%), Positives = 73/132 (55%), Gaps = 2/132 (1%)

Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRR--EEESRRLEAEQAREKE 543
           KR+L  E++++ E+++ ++  LE Q+R E   R  +ER  RR  +EE RRLE  + R KE
Sbjct: 388 KRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKE 447

Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
           E+ +R+AEE   R   E E  +RQ EEE R  E  ++   + +          +E  ++ 
Sbjct: 448 EEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQA 507

Query: 604 EEIMKRTRRTEA 615
           E + ++ ++ +A
Sbjct: 508 ERLQRQLQQEQA 519



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 50/155 (32%), Positives = 82/155 (52%), Gaps = 21/155 (13%)

Query: 488 RLAREQREKEERE------RREQEELERQKREELA-QRVAEERTTRREEESRRLEAEQAR 540
           R  +++ EK+E E        E+EE+  Q+ E  +   V  E T RR+    RL+ E  +
Sbjct: 308 RTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD--FLRLQQEN-K 364

Query: 541 EKEEQLQRQA--EERALREREE------AERAQR---QKEEEARVREEAERVRQEREKHF 589
           E+ E L+RQ   +E+ LRE+EE      AER +R   QKE+  R+ E+  R R+ R +  
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424

Query: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           + + +   E K+RLEE+ +R +  E   +   ++R
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459



 Score = 54.7 bits (130), Expect = 3e-07
 Identities = 35/91 (38%), Positives = 54/91 (59%), Gaps = 6/91 (6%)

Query: 66  RQRLA-RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           RQ LA R++R E++K+   R      RE  AR+  E+  E+R++  EE+R+ EE  R   
Sbjct: 389 RQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQER--EQRRREQEEKRRLEELERRRK 446

Query: 125 EEKRRQRLEEDK---ERHEAVVRRTMERSQK 152
           EE+ R+R EE+K   ER +  +RR +E  Q+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 34/93 (36%), Positives = 57/93 (61%), Gaps = 11/93 (11%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKH----LEERKKRLEEQRQ-KEE 118
           + R+RL  ++R ERE   A R+    ERE+R R+  EK     LE R+K  EE+R+ +EE
Sbjct: 404 EQRRRLEEQQRRERE---ARRQ---QEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ 151
           +RR   E++  +R  E+++RH  V+++ + + Q
Sbjct: 458 KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 32/113 (28%), Positives = 60/113 (53%), Gaps = 9/113 (7%)

Query: 56  DPPPVLRVDDRQRLARE----RREEREKQLAAREIVWLEREE-RARQHYEKHL-EERKKR 109
           +P  ++ V     L R+    ++E +E+  A R    L+ ++ R ++ Y++ L  ER+KR
Sbjct: 339 EPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398

Query: 110 LE---EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           +E   EQR++ E ++    E RRQ+  E + R +   RR  E  ++ K++  R
Sbjct: 399 IEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 8/100 (8%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQ-------HYEKHLEERKKRLEEQRQKEER 119
           Q+  +ER E   +Q   +E    E+EE  RQ         E+  E+R++  E+QR++ E 
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           RR    E+RR R +E+K R E + RR  E  ++ + +  +
Sbjct: 420 RRQQEREQRR-REQEEKRRLEELERRRKEEEERRRAEEEK 458



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 46/209 (22%), Positives = 81/209 (38%), Gaps = 14/209 (6%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK---------E 117
           + L R R+EE E++ A  E     R ER +++  + LEE ++ LE  +Q+         E
Sbjct: 439 EELERRRKEEEERRRAEEE---KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLE 495

Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGS-PSIHSAD 176
            R R   E ++ +RL+   ++ +A +       ++P  +H++         S PS H+ +
Sbjct: 496 CRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPE 555

Query: 177 PDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSF 236
           P +      + ++ V+    K   SS         R     +     S  N      H  
Sbjct: 556 P-KAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPA 614

Query: 237 LARSKSTAALSGEAASCSPIIMPYKAAHS 265
           L R           AS    + P   +HS
Sbjct: 615 LQRPAEPQVQWSHLASLKNNVSPVSRSHS 643



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 27/135 (20%)

Query: 508 ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE-------- 559
           ERQ R +L   +   R  R E++    E   + E+EE+         + E+E        
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE---------VPEQEGEPSSIVN 345

Query: 560 -----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQE-----RLERKKRLEEIMKR 609
                   R   + ++E + R EA R +Q  ++   RE++E       ER+KR+E+  ++
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQ 405

Query: 610 TRRTEATDKKTSDQR 624
            RR E   ++  + R
Sbjct: 406 RRRLEEQQRREREAR 420


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 42/122 (34%), Positives = 81/122 (66%), Gaps = 7/122 (5%)

Query: 492 EQREKEERERREQEELERQKREELAQRVAE----ERTTRREEESRRLEAEQAREKEEQLQ 547
           EQ +K+E +  EQEE  R++ E++ ++  +    E   +++EE  R + EQ RE+EEQ+ 
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM- 271

Query: 548 RQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ--ERLERKKRLEE 605
           R+ EE+ L+++E+ E+ ++  E+E ++RE+ E++R++ E+  ++EEQ  E+ E+  + EE
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331

Query: 606 IM 607
            M
Sbjct: 332 QM 333



 Score = 73.6 bits (179), Expect = 6e-13
 Identities = 47/152 (30%), Positives = 93/152 (61%), Gaps = 11/152 (7%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA---QRVAEERTTRREEES 531
           + EE  +   E+ +   EQ  K+E + REQEE  R++ E++    ++  +E  T  +EE 
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297

Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
            R + EQ RE+EEQ++ Q E+  +RE+EE    Q  K+EE ++ E+ E++ +++E+ +++
Sbjct: 298 MREQEEQMREQEEQMREQEEQ--MREQEE----QMGKQEE-QMWEQKEQMWEQKEQMWKQ 350

Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           EEQ   E+++++++  ++ R+ E   +K  +Q
Sbjct: 351 EEQMG-EQEEQMQKQEEQVRKQEEQMRKQEEQ 381



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 41/154 (26%), Positives = 88/154 (57%), Gaps = 6/154 (3%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEEL---ERQKREELAQRVAEERTTRREEESRR 533
           EE  +   E+ R   EQ  ++E + REQEE    ++++ E+  Q   +E   R +EE  R
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
            + EQ RE+EEQ++ Q E+   +E +  E+ ++  E++ ++ ++ E++ ++ E+  ++EE
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEE 366

Query: 594 QERLER---KKRLEEIMKRTRRTEATDKKTSDQR 624
           Q R +    +K+ E++ K+  +    +++  +Q+
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQK 400



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 53/168 (31%), Positives = 94/168 (55%), Gaps = 22/168 (13%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           + EE  +   E+     EQ  K+E +  EQEE + QK+EE  Q+  +E   R++EE  R 
Sbjct: 210 EQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE-QVQKQEEQVQK--QEEQMRKQEEQMRE 266

Query: 535 EAEQAREKEEQLQRQAE-----------ERALREREEAERAQRQ--KEEEARVREEAERV 581
           + EQ RE+EEQ+ +Q E           E  +RE+EE  R Q +  +E+E ++RE+ E++
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQM 326

Query: 582 RQEREKHFQREEQ--ERLERKKRLEEIM----KRTRRTEATDKKTSDQ 623
            ++ E+ ++++EQ  E+ E+  + EE M    ++ ++ E   +K  +Q
Sbjct: 327 GKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQ 374



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 41/145 (28%), Positives = 87/145 (60%), Gaps = 10/145 (6%)

Query: 477 EEATRLLAEKRRLAREQREKEERER-REQEELERQKREELAQRVAEERTTRREEESRRLE 535
           E+  ++L +K +  +E++  E+ E+ REQEE  R++ E++ +   +E   R +EE    +
Sbjct: 273 EQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE---QEEQMREQEEQMGKQ 329

Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
            EQ  E++EQ+  Q E+   +E +  E+ ++ +++E +VR++ E++R++ E+  ++EEQ 
Sbjct: 330 EEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389

Query: 596 RL------ERKKRLEEIMKRTRRTE 614
           R       E+K+++ E  ++ R  E
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQE 414



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 39/145 (26%), Positives = 91/145 (62%), Gaps = 5/145 (3%)

Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAE--ERTTRREEES 531
           T+ EE T    E+ R   EQ  ++E + REQEE  R++ E++ ++  +  E+  +  E+ 
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344

Query: 532 RRL--EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHF 589
            ++  + EQ  E+EEQ+Q+Q E+   +E +  ++ ++ +++E ++R++ E++ +++E+  
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404

Query: 590 QREEQERLERKKRLEEIMKRTRRTE 614
           +++EQ R E+++++ E  ++ R+ E
Sbjct: 405 EQKEQMR-EQEEQMGEQKEQMRKQE 428



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 45/148 (30%), Positives = 82/148 (55%), Gaps = 5/148 (3%)

Query: 477 EEATRLLAEKRRLAREQ--REKEERERREQE-ELERQKREELAQRVAEERTTRREEESRR 533
           EE  R   E+ R   EQ  ++KE+ E+ EQ  E E Q RE+  Q   +E   R +EE  R
Sbjct: 261 EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
            + EQ  ++EEQ+  Q E+   ++ +  ++ ++  E+E +++++ E+VR++ E+  ++EE
Sbjct: 321 EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE 380

Query: 594 QERL--ERKKRLEEIMKRTRRTEATDKK 619
           Q R   E+ ++ EE M   +      K+
Sbjct: 381 QMRKQEEQMRKQEEQMGEQKEQMGEQKE 408



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 43/162 (26%), Positives = 88/162 (54%), Gaps = 7/162 (4%)

Query: 467 VKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTR 526
           V+   G    +E      E +   +E +  E+ E+  ++E + QK+EE  Q   +E   R
Sbjct: 173 VREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE--QMGEQEEQMR 230

Query: 527 REEESRRLEAEQAREKEEQLQRQAEERALRE---REEAERAQRQKEEEARVREEAERVRQ 583
           ++EE    + EQ +++EEQ+Q+Q E+   +E   RE+ E+ + Q+E+  + +E+ E+  Q
Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQ 290

Query: 584 --EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
             E+E+  + +E++  E+++++ E  ++ R  E    K  +Q
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQ 332



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 37/130 (28%), Positives = 71/130 (54%), Gaps = 11/130 (8%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEEL-----------ERQKREELAQRVAEER 523
           + EE  R   E+ R   EQ  K+E +  EQ+E            E Q  E+  Q   +E 
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEE 366

Query: 524 TTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ 583
             R++EE  R + EQ R++EEQ+++Q E+   ++ +  E+ ++ +E+E ++ E+ E++R+
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426

Query: 584 EREKHFQREE 593
           + E   +++E
Sbjct: 427 QEEHMGEQKE 436



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 38/141 (26%), Positives = 77/141 (54%), Gaps = 2/141 (1%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
           E+    REQ  +   +  +  E E Q RE+  Q   +E     +E     + EQ  E+EE
Sbjct: 154 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEE 213

Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ--ERLERKKR 602
           Q+Q+Q E+   +E +  ++ ++  E+E +V+++ E+V+++ E+  ++EEQ  E+ E+ + 
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE 273

Query: 603 LEEIMKRTRRTEATDKKTSDQ 623
            EE M + +     +++T +Q
Sbjct: 274 QEEQMLKQKEQTEQEEQTGEQ 294



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 39/141 (27%), Positives = 78/141 (55%), Gaps = 3/141 (2%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
           E+    REQ  +   +  +  E E Q RE+  Q   +E     +EE    + EQ +++EE
Sbjct: 161 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220

Query: 545 QLQRQAEERALREREEAERAQR-QKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
           Q+  Q E+   +E +  E+ ++ QK+EE  V+++ E++R++ E+  ++EEQ R + ++ L
Sbjct: 221 QMGEQEEQMRKQEEQMGEQEEQVQKQEEQ-VQKQEEQMRKQEEQMREQEEQMREQEEQML 279

Query: 604 EEIMKRTRRTEATDKKTSDQR 624
           ++  ++T + E T ++    R
Sbjct: 280 KQ-KEQTEQEEQTGEQEEQMR 299



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 38/140 (27%), Positives = 76/140 (54%), Gaps = 4/140 (2%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
           E+    REQ  +   +  +  E E Q  E+  Q   +E     +EE  + + EQ  E+EE
Sbjct: 168 EQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227

Query: 545 QLQRQAEERALRERE-EAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
           Q+++Q E+   +E + + +  Q QK+EE  +R++ E++R++ E+   RE++E++ ++K  
Sbjct: 228 QMRKQEEQMGEQEEQVQKQEEQVQKQEEQ-MRKQEEQMREQEEQ--MREQEEQMLKQKEQ 284

Query: 604 EEIMKRTRRTEATDKKTSDQ 623
            E  ++T   E   ++  +Q
Sbjct: 285 TEQEEQTGEQEEQMREQEEQ 304



 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 34/139 (24%), Positives = 73/139 (52%), Gaps = 4/139 (2%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
           E+    REQ  +   +  +  E E Q RE+  Q   +E   R +E   R +  Q RE+E 
Sbjct: 133 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 192

Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLE 604
           Q+  Q  +   +E +  E+ ++ +++E ++ E+ E++R++ E+  ++EEQ     +K+ E
Sbjct: 193 QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQV----QKQEE 248

Query: 605 EIMKRTRRTEATDKKTSDQ 623
           ++ K+  +    +++  +Q
Sbjct: 249 QVQKQEEQMRKQEEQMREQ 267



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 35/140 (25%), Positives = 71/140 (50%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
           E+    REQ  +   +  +  E E Q RE+  Q   +E   R +E   R +  Q RE+E 
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 178

Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLE 604
           Q++ Q  +   +E +  E+  +  E+E ++ E+ E+++++ E+  ++EEQ R + ++  E
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238

Query: 605 EIMKRTRRTEATDKKTSDQR 624
           +  +  ++ E   K+    R
Sbjct: 239 QEEQVQKQEEQVQKQEEQMR 258



 Score = 53.9 bits (128), Expect = 5e-07
 Identities = 48/191 (25%), Positives = 89/191 (46%), Gaps = 16/191 (8%)

Query: 447 PVPTPAMVSAPSSTVNAS-ASVKTSAGTTDPEEATRLLAEKRRLAREQR---EKEERERR 502
           P+P    V      V      V+   G    +E    + E+    REQ     ++E + R
Sbjct: 47  PLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEGQVR 104

Query: 503 EQE----ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRER 558
           EQE    E E Q RE+  Q   +E   R +E   R +  Q RE+E Q++ Q  +   +E 
Sbjct: 105 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 164

Query: 559 EEAERAQRQKEEEARVREEAERVRQ------EREKHFQREEQERLERKKRLEEIMKRTRR 612
           +  E+  + +E+E +VRE+  +VR+      E+E     +E++  E+++++++  ++   
Sbjct: 165 QVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE 224

Query: 613 TEATDKKTSDQ 623
            E   +K  +Q
Sbjct: 225 QEEQMRKQEEQ 235



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 47/179 (26%), Positives = 85/179 (47%), Gaps = 7/179 (3%)

Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAE-KRRLAREQRE-KEERERREQE--- 505
           P + +      NA    +     T+  E    + E KR+L  ++    +E + REQE   
Sbjct: 2   PRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQV 61

Query: 506 -ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERA 564
            E E Q RE+  Q   +E   R +E   R +  Q RE+E Q++ Q  +   +E +  E+ 
Sbjct: 62  REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 121

Query: 565 QRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
            + +E+E +VRE+  +VR E+E   + +E +  E++ ++ E   + R  E   ++   Q
Sbjct: 122 GQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 179



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 25/83 (30%), Positives = 51/83 (61%), Gaps = 2/83 (2%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRRAAVEEKRR 129
           E+  E+E+Q+  +E    E+EE+ R+  E+    EE+ ++ EEQ QK+E +    EE+ R
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265

Query: 130 QRLEEDKERHEAVVRRTMERSQK 152
           ++ E+ +E+ E ++++  +  Q+
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQE 288



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 26/101 (25%), Positives = 54/101 (53%), Gaps = 9/101 (8%)

Query: 60  VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
           V + +++ R   E+  E+E+Q+  +E   L+++E+  Q      EE+    EEQ +++E 
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ------EEQTGEQEEQMREQEE 303

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
           +    EE+ R++ E+ +E+ E + +   +  Q  +QK   W
Sbjct: 304 QMREQEEQMREQEEQMREQEEQMGK---QEEQMWEQKEQMW 341



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 21/97 (21%), Positives = 53/97 (54%), Gaps = 2/97 (2%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           +++ +   E+ +++E+Q+  +E    E+EE+ R+  E+ L+++++  +E++  E+  +  
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
            +E++ +  EE     E  +R   +  Q  KQ+   W
Sbjct: 300 EQEEQMREQEEQMREQEEQMRE--QEEQMGKQEEQMW 334



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 21/94 (22%), Positives = 54/94 (57%), Gaps = 1/94 (1%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK-EERRRA 122
           +++ R   E+  E+E+Q+  +E    E+EE+  +  E+  E++++  E++ Q  ++  + 
Sbjct: 295 EEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM 354

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             +E++ Q+ EE   + E  +R+  E+ +K +++
Sbjct: 355 GEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ 388



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 21/92 (22%), Positives = 49/92 (53%), Gaps = 3/92 (3%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQKEERR 120
           +++ +   E+  E+E+Q+  +E    E+EE+ ++  E   K  E+ +K+ E+ R++EE+ 
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271

Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
           R   E+  +Q+ + ++E         M   ++
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEE 303



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 19/96 (19%), Positives = 54/96 (56%), Gaps = 1/96 (1%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           +++ R   E+  E+E+Q+  +E    ++EE+ R+  E+ + E+++++ EQ ++  +++  
Sbjct: 226 EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQ-EEQMREQEEQMREQEEQMLKQKEQ 284

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            E++ +   +E++ R +    R  E   + +++  R
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 23/96 (23%), Positives = 55/96 (57%), Gaps = 5/96 (5%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERK---KRLEEQRQKEERR 120
           +++ R   E+  E+E+Q+  +E    ++EE+  +  E+  E+++   K+ E+  ++EE+ 
Sbjct: 302 EEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361

Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           +   E+ R+Q  EE   + E  +R+  E+ +K +++
Sbjct: 362 QKQEEQVRKQ--EEQMRKQEEQMRKQEEQMRKQEEQ 395



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 22/93 (23%), Positives = 49/93 (52%), Gaps = 8/93 (8%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ- 130
           E+  E+E+Q+  +E    E+EE+ R+  E+  E+ ++  +++ Q  E++    E+K +  
Sbjct: 289 EQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348

Query: 131 -------RLEEDKERHEAVVRRTMERSQKPKQK 156
                    EE  ++ E  VR+  E+ +K +++
Sbjct: 349 KQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQ 381



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 20/89 (22%), Positives = 43/89 (48%), Gaps = 5/89 (5%)

Query: 75  EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEE 134
           E++E+    +E +W + E+   Q      E+ +K+ E+ R++EE+ R   E+ R+Q  + 
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQE-----EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389

Query: 135 DKERHEAVVRRTMERSQKPKQKHNRWSWG 163
            K+  +   ++     QK + +      G
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQEEQMG 418



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 22/90 (24%), Positives = 52/90 (57%), Gaps = 5/90 (5%)

Query: 71  RERREEREKQLAAREIVWLEREERARQHYE--KHLEERKKRLEEQRQKEERRRAAVEEKR 128
           +E+  ++E+Q+  +E    ++EE+ R+  E  +  EE+ ++ EEQ +K+E +    +E+ 
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403

Query: 129 RQRLEEDKERHEAVVRRTMERSQKPKQKHN 158
            ++ E+ +E+ E +     ++ Q  KQ+ +
Sbjct: 404 GEQKEQMREQEEQMGE---QKEQMRKQEEH 430



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 16/72 (22%), Positives = 42/72 (58%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           +++ +   E+  ++E+Q+  +E    ++EE+ R+  E+  E++++  E++ Q  E+    
Sbjct: 358 EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM 417

Query: 124 VEEKRRQRLEED 135
            E+K + R +E+
Sbjct: 418 GEQKEQMRKQEE 429



 Score = 33.9 bits (76), Expect = 0.57
 Identities = 28/115 (24%), Positives = 58/115 (50%), Gaps = 4/115 (3%)

Query: 45  GQNNNHSGNKPDPPPVLRVDDRQRLARERR-EEREKQLAAREIVWLEREERARQHYE--K 101
           GQ     G   +    +R  + Q   +E +  E+E Q+  +E    E+EE+  +  E  +
Sbjct: 157 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQ 216

Query: 102 HLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             EE+    EEQ +K+E +    +E++ Q+ EE  ++ E  +R+  E+ ++ +++
Sbjct: 217 KQEEQMGEQEEQMRKQEEQMGE-QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQ 270


>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens]
          Length = 1341

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 61/214 (28%), Positives = 93/214 (43%), Gaps = 45/214 (21%)

Query: 437  PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREK 496
            P P   P P PV  P    A                    E+  +  A + + A  +RE 
Sbjct: 1114 PRPLHPPPPPPVQPPQHPRA--------------------EQREQERAVREQWAEREREM 1153

Query: 497  EERER-REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERAL 555
            E RER R + E +R K  E  +  +  R  RR+E ++    E+  EK+E+ Q +   + L
Sbjct: 1154 ERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAK--SKEKKSEKKEKAQEEPPAKLL 1211

Query: 556  RE----------------------REEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
             +                      ++EAERA+R KE E R +E+ E  ++EREK  +RE 
Sbjct: 1212 DDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERER 1271

Query: 594  QERLERKKRLEEIMKRTRRTEATDKKTSDQRNGD 627
              +LER+KR E   +R R  E   ++    R+ D
Sbjct: 1272 NRQLEREKRREHSRERDRERERERERDRGDRDRD 1305



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 33/116 (28%), Positives = 58/116 (50%), Gaps = 11/116 (9%)

Query: 486  KRRLAREQREKEERERREQEELERQK-REELAQRVAEERTTRREEESRRLEAEQAREKEE 544
            ++   R +R KE  +RR+++E E QK RE+ A+R          E +R+LE E+ RE   
Sbjct: 1236 QKEAERAERAKEREKRRKEQEEEEQKEREKEAER----------ERNRQLEREKRREHSR 1285

Query: 545  QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
            +  R+ E    R+R + +R + +  E  R R+  +  R  R +      ++R  R+
Sbjct: 1286 ERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 68/287 (23%), Positives = 118/287 (41%), Gaps = 18/287 (6%)

Query: 458 SSTVNASASVKTSAGTTDPEEATRLLAEKRRL---AREQREKEERERREQEELERQKREE 514
           SS V  + + K S G+   EE        R L   A    + EE E  E+EE E  + EE
Sbjct: 228 SSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEE 287

Query: 515 LAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQR--QKEEEA 572
                 + R     +E +    E  R K E++  +  +   +E+E  ER  R  + +EEA
Sbjct: 288 GDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEA 347

Query: 573 RVREEAERVRQEREKHFQREEQ-ERLERKKRLEEIMKRTRRTEATDKKTSDQRNGD-IAK 630
           R   ++   RQ++EK  +     E  ER+ +  + +K   ++ +  + T D++    +A 
Sbjct: 348 R---KSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVAL 404

Query: 631 GALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQ---PNENGVSV 687
              T   E +  P  T    +  P   P + +  + +      P +  Q   PN +  + 
Sbjct: 405 PEQTASEEETPPPLLTKEASSPPP--HPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTR 462

Query: 688 QNENFEEIINLPIGSKP-SRLDVTNSESP--EIPLNPILAFDDEGTL 731
           +    +  + L  G  P S    T +ESP  ++P   +L    + TL
Sbjct: 463 ELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTL 509



 Score = 51.2 bits (121), Expect = 3e-06
 Identities = 25/104 (24%), Positives = 48/104 (46%)

Query: 477  EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
            +EA R    K R  R + ++EE ++  ++E ER++  +L +    E +  R+ E  R   
Sbjct: 1237 KEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERE 1296

Query: 537  EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
                +++   +R  E    R+R + +R  R +     VR+   R
Sbjct: 1297 RDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGR 1340



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 29/98 (29%), Positives = 51/98 (52%), Gaps = 15/98 (15%)

Query: 62   RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
            R  +R++  +E+ EE +K          ERE+ A +   + LE R+KR E  R+++  R 
Sbjct: 1244 RAKEREKRRKEQEEEEQK----------EREKEAERERNRQLE-REKRREHSRERDRERE 1292

Query: 122  AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
                E+ R R + D++R E    R  ER ++  ++H+R
Sbjct: 1293 ---RERERDRGDRDRDR-ERDRERGRERDRRDTKRHSR 1326



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 5/94 (5%)

Query: 66   RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
            R+    E ++EREK+        LERE+R R+H  +   ER++  E  R   +R R    
Sbjct: 1252 RKEQEEEEQKEREKEAERERNRQLEREKR-REHSRERDRERERERERDRGDRDRDRERDR 1310

Query: 126  EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            E+ R+R   D +RH     R+  RS   + +  R
Sbjct: 1311 ERGRERDRRDTKRHS----RSRSRSTPVRDRGGR 1340



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 35/132 (26%), Positives = 60/132 (45%), Gaps = 27/132 (20%)

Query: 55   PDPPPVL-----RVDDR--QRLARERREEREKQLAAREIVWLERE-------ERARQHYE 100
            P PPPV      R + R  +R  RE+  ERE+++  RE    ERE       E  R    
Sbjct: 1120 PPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSR 1179

Query: 101  KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEA-------------VVRRTM 147
                 RK+R + + +K E++  A EE   + L++   + +A             +V++  
Sbjct: 1180 SRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEA 1239

Query: 148  ERSQKPKQKHNR 159
            ER+++ K++  R
Sbjct: 1240 ERAERAKEREKR 1251



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 63/326 (19%), Positives = 115/326 (35%), Gaps = 49/326 (15%)

Query: 373 KREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPA 432
           +RE+K     K+  K P         K +A LV + E T  E     P +   A +  P 
Sbjct: 371 EREIKSSQGLKEKSKSPSPPRLTEDRK-KASLVALPEQTASEEETPPPLLTKEASSPPPH 429

Query: 433 PASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTD----------------- 475
           P         P   P P   +  +P +T   +  +  S  T                   
Sbjct: 430 PQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAE 489

Query: 476 ------PEEATRLLAEKRRLAREQREKE---ERERREQEELERQKREELAQRVAEE---R 523
                 PEE+   L +K  LA    +K+   E +R  Q    + +   LA+ + EE   +
Sbjct: 490 SPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQ 549

Query: 524 TTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK---------EEEARV 574
            +  ++E RR  A        +L++ A+  + R    +  + R +            + +
Sbjct: 550 PSLEQKEGRR--ASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPL 607

Query: 575 REEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALT 634
           R +   V Q R  H     + ++  +   E   +   R+ +    +    +  +++ + T
Sbjct: 608 RSKQRDVAQAR-THANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSST 666

Query: 635 GGTEVSALPCTTNAPGNGKPVGSPHV 660
             TE       T  P +G+ V +P V
Sbjct: 667 SYTE-------TKDPSSGQEVATPPV 685



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 44/200 (22%), Positives = 77/200 (38%), Gaps = 20/200 (10%)

Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLL-----AEKRRLARE-QREKEERERREQ 504
           P  V    ST    A ++       P +A R+       E+R LA+  Q+    +  +  
Sbjct: 46  PEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGA 105

Query: 505 EELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERA 564
             LE  ++        +  +   EE S+    +Q  EK+++L RQ  ER  RE  E E A
Sbjct: 106 LMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEA 165

Query: 565 QRQKEEE------------ARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRR 612
             + E+E               +   ER   E  +H  R+     E K   ++  ++ R+
Sbjct: 166 SAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDD--EKPRK 223

Query: 613 TEATDKKTSDQRNGDIAKGA 632
            E    +    R   +++G+
Sbjct: 224 GERRSSRVRQARAAKLSEGS 243


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 77.4 bits (189), Expect = 4e-14
 Identities = 52/165 (31%), Positives = 95/165 (57%), Gaps = 18/165 (10%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL---AQRVAEERTTRREEESRR 533
           EE  R   +K R   E+  ++E   REQE   R++ E++    +R+ E+    RE+E   
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337

Query: 534 LEAEQAREKEEQLQRQAE-----ERALREREEAERAQRQK--EEEARVREEAERVRQERE 586
            E ++ RE+EEQ+Q Q E     E  +RE+EE    Q ++  E+E ++RE+ +++R + E
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397

Query: 587 KHFQ-----REEQERL-ERKKRLEEI--MKRTRRTEATDKKTSDQ 623
           + ++     RE++ER+ E++K  E++  M+  ++ +  +KKT DQ
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ 442



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 45/152 (29%), Positives = 91/152 (59%), Gaps = 12/152 (7%)

Query: 483 LAEKRRLAREQREK----EERERREQEELERQKREELAQRVAEERTTRREEESRRL--EA 536
           L E+    REQ EK    E+R R +++EL  Q++E   Q+   E+  + +E+  ++  + 
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361

Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ-- 594
           E+ RE+EE++ RQ E    +E++  E+ Q+ +++E R+ E+ ER+R++ E+  ++E+   
Sbjct: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 421

Query: 595 --ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
             E++  +K+++E  K+TR  E  +K   ++R
Sbjct: 422 QVEKMREEKKMQEQEKKTRDQE--EKMQEEER 451



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 46/164 (28%), Positives = 99/164 (60%), Gaps = 19/164 (11%)

Query: 477 EEATRLLAEKRRLAREQRE--KEERERREQEEL---ERQKREELAQRVAEERTTRREEES 531
           E+  ++  +++RL  +++E  ++E+E REQ+EL   E Q +E+  +   +E   R +EE 
Sbjct: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370

Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEA--ERAQRQKEEEARVR------EEAERVRQ 583
              + E+  E+E+Q++ Q  E+ +R++EE   E+ +R +E+E R+R      E+ E++R+
Sbjct: 371 MWRQEERLWEQEKQMREQ--EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE 428

Query: 584 EREKHFQ----REEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           E++   Q    R+++E+++ ++R+ E  K+ R  E T ++  ++
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK 472



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 50/153 (32%), Positives = 85/153 (55%), Gaps = 11/153 (7%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKRE-ELAQRVAEERTTRREEESRRLE 535
           +E    + E+    REQ EK  R+     E E+Q RE E   R  EER   ++E  R  E
Sbjct: 351 QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 410

Query: 536 AEQAREKE---EQLQRQAEERALREREEAERAQRQK-EEEARVREEAERVRQEREKHFQR 591
            E+ RE+E   EQ+++  EE+ ++E+E+  R Q +K +EE R+RE  +++R+E E    R
Sbjct: 411 -ERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET--MR 467

Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           E++E+++++   EE M      E   ++  +Q+
Sbjct: 468 EQEEKMQKQ---EENMWEQEEKEWQQQRLPEQK 497



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 45/159 (28%), Positives = 93/159 (58%), Gaps = 22/159 (13%)

Query: 485 EKRRLAREQREKEERERREQEELERQKRE-ELAQRVAEERTTRREEESRRLEAEQAREKE 543
           E++   +EQ+  ++ ER E++  E++K+  +  +++ EE   R  E+  R E E  RE+E
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609

Query: 544 EQLQRQAEERALREREEA--ERAQRQKEEEARVREEAERVRQEREK-------------- 587
           E++Q Q E+  ++E+EE   E+ ++ +E+E ++ E+ E++ ++ EK              
Sbjct: 610 EKMQEQEEK--MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667

Query: 588 --HFQREEQERL-ERKKRLEEIMKRTRRTEATDKKTSDQ 623
             H + +EQE++ E+++++ E  K  ++T+  +KKT DQ
Sbjct: 668 WEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ 706



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 52/152 (34%), Positives = 90/152 (59%), Gaps = 17/152 (11%)

Query: 476 PEEATRLLAEKR-RLAREQREKEERERREQEEL----ERQKREELAQRVAEERTTRREEE 530
           P+  T  L E+  R   E RE+E++ R+++E++    ER + +E   R  EE+  R+E+ 
Sbjct: 263 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKR 322

Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERV-RQ---- 583
            R  E E  RE+E++L+ Q E   LRE+EE  + Q +K  E+E ++RE+ E++ RQ    
Sbjct: 323 LREQEKE-LREQEKELREQKE---LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 378

Query: 584 -EREKHFQREEQERLERKKRLEEIMKRTRRTE 614
            E+EK  + +EQ+  ++++R+ E  +R R  E
Sbjct: 379 WEQEKQMREQEQKMRDQEERMWEQDERLREKE 410



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 42/164 (25%), Positives = 95/164 (57%), Gaps = 10/164 (6%)

Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA-----QRVAEERTTRREEE 530
           PE+  +L   ++   +E+ +++E +  EQE++E++ +E+       +++ EE + R  E+
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720

Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREK--- 587
             R E E  RE+EE++Q Q E+   +E E  E+ ++  E+E ++ E+ +R+ +++EK   
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ-QRLPEQKEKLWE 779

Query: 588 HFQREEQERL-ERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
           H + +EQE++ E+++++ +  ++ R  E   +   ++  G   K
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK 823



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 40/158 (25%), Positives = 91/158 (57%), Gaps = 11/158 (6%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRRE---EESRR 533
           E+  ++  ++ RL  ++++  E+E++ +++ ER   ++   R  EER   +E   E+  +
Sbjct: 366 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
           +  E+  +++E+  R  EE+   E    ER ++ +EEE  +RE+ E+++++ E  +++EE
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 485

Query: 594 ----QERL-ERKKRL---EEIMKRTRRTEATDKKTSDQ 623
               Q+RL E+K++L   E++ ++  +    ++K  DQ
Sbjct: 486 KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 44/164 (26%), Positives = 94/164 (57%), Gaps = 26/164 (15%)

Query: 485 EKRRLAREQREKEERERREQEEL--ERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
           EK R   +Q  ++E + R+QE+   ++++R E   +  E++T  +EE+ R  E  + REK
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596

Query: 543 ----EEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREEQ-- 594
               EE++ R+ EE+ ++E+EE  + Q +K  E+E +++E+ E++ ++ EK +++EE+  
Sbjct: 597 KMREEEEMMREQEEK-MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655

Query: 595 ---------------ERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
                          E+++ +++++E  ++    E  +KKT +Q
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 40/174 (22%), Positives = 93/174 (53%), Gaps = 27/174 (15%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQ--RVAEERTTRREEESRRL 534
           E+  R+  +++   + ++ +EE++ +EQE+  R + E++ +  R+ E     REEE    
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMR 467

Query: 535 EAEQAREKEEQLQRQAEERALRERE---------EAERAQRQK----EEEARVREE---- 577
           E E+  +K+E+   + EE+  +++          E E+ Q Q+    E+E ++R++    
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527

Query: 578 --------AERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
                    E++R++ ++ +++EE+ R + +K  ++  +  ++T+  +KKT DQ
Sbjct: 528 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 44/166 (26%), Positives = 88/166 (53%), Gaps = 17/166 (10%)

Query: 476 PEEATRLLAEKRRLAREQREKEERER-REQEEL--------ERQKREELAQRVAEERTTR 526
           PE+  +L  +++   +E++  E+ E+ R+QEE+         ++K  E   ++ E+    
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM 553

Query: 527 REEESRRLEAEQAREKEEQLQRQA----EERALREREEAERAQRQKEEEARVREEAERVR 582
           R++E +  + E+  EK+ Q Q +     EE+   E    ER ++ +EEE  +RE+ E+++
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 613

Query: 583 QEREKHFQREEQ--ERLERKKRLEEIM--KRTRRTEATDKKTSDQR 624
           ++ EK  ++EE+  E+ E+ +  EE M  +  +  E  +K    QR
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 46/167 (27%), Positives = 89/167 (53%), Gaps = 16/167 (9%)

Query: 473 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ--KREELAQRVAEERTTRREEE 530
           T D EE  R     R   ++ RE+EE  R ++E+++ Q  K +E  +++ E+    +E+E
Sbjct: 578 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQE 637

Query: 531 SRRLEAEQAR-EKEEQLQRQA----EERALREREEAERAQRQKEEEARV--REEAERVRQ 583
            +  E E+   E+EE++  Q     ++  L E E+ +  ++ +E+E ++  +E+ E+  Q
Sbjct: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ 697

Query: 584 EREKHF-----QREEQERLERKKRL--EEIMKRTRRTEATDKKTSDQ 623
           E+EK        REE+   ER+K++  EE M R +  +  +++   Q
Sbjct: 698 EQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQ 744



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 41/131 (31%), Positives = 80/131 (61%), Gaps = 10/131 (7%)

Query: 497 EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALR 556
           +E   R++EEL  Q+++   Q   EE+  R+EE  R  E +  RE+EE++ RQ  E+ LR
Sbjct: 271 QEEMWRQEEELREQEKKIRKQ---EEKMWRQEERLREQEGKM-REQEEKMWRQ--EKRLR 324

Query: 557 EREEAERAQ-RQKEEEARVREEAERVRQEREKHFQREEQERLERKK---RLEEIMKRTRR 612
           E+E+  R Q ++  E+  +RE+ E+++++ EK +++EE+ R + +K   + E + ++ ++
Sbjct: 325 EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384

Query: 613 TEATDKKTSDQ 623
               ++K  DQ
Sbjct: 385 MREQEQKMRDQ 395



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 41/150 (27%), Positives = 83/150 (55%), Gaps = 7/150 (4%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           + EE  +   EK     E+  ++E +  EQ+ L  QK +       +E+   +E+E +  
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687

Query: 535 EAEQAREK-EEQLQRQAEERALREREEA-ERAQRQKEEEARVREEAERVRQEREKHFQRE 592
           E E+  +K +EQ ++  ++  +RE E   ER ++ +EEE  +RE+ E++ QE+E+  Q +
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM-QEQEEKMQEQ 746

Query: 593 EQERLERKKRL----EEIMKRTRRTEATDK 618
           E+E  E+++++    E++ ++ R  E  +K
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 42/147 (28%), Positives = 75/147 (51%), Gaps = 13/147 (8%)

Query: 481 RLLAEKRRLAREQREKEERERR-EQEELERQKREELAQRVAEERTTR-REEESRRLEAEQ 538
           RL  +K +L  +++ +E+ E+  EQEE  R + E   Q     R  + RE+E +  E E+
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551

Query: 539 AREKEEQLQRQAEERALREREEAER-----------AQRQKEEEARVREEAERVRQEREK 587
               +EQ     EER  ++ +E E+            +R +E E ++REE E +R++ EK
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611

Query: 588 HFQREEQERLERKKRLEEIMKRTRRTE 614
             ++EE+ + + +K  E+  K   + E
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEE 638



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/130 (27%), Positives = 71/130 (54%), Gaps = 4/130 (3%)

Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQ--KREELAQRVAEERTTRREEES 531
           T  +E      EK R     RE+E++ R E+E +  Q  K +E  +++ E+     E+E 
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755

Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
           +  E E+   ++++L  Q E+  L E E+ +  ++  E+E ++R++ E++R + EK   +
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEK--LWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQ 813

Query: 592 EEQERLERKK 601
           EE+ R + +K
Sbjct: 814 EEKMRGQEEK 823



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 38/157 (24%), Positives = 92/157 (58%), Gaps = 20/157 (12%)

Query: 477 EEATRLLAEKRRLAREQ---REKEERERREQEEL-ERQKREELAQRVAEERTTRREEESR 532
           +E  R+   ++++  E+   RE+EE+ ++++E + E++++E   QR+ E++    E+E  
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 506

Query: 533 RLEAEQAREKEEQLQRQAE----------ERALREREEA--ERAQRQKEEEARVREEAER 580
           + + E+  E+EE+++ Q E          +  +RE+E+   E+ ++ +++E ++ ++ ER
Sbjct: 507 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 566

Query: 581 V---RQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
           +    QE+EK    +++E++  ++R+ E  K+ R  E
Sbjct: 567 MEKKTQEQEKK-TWDQEEKMREEERMREREKKMREEE 602



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 49/152 (32%), Positives = 88/152 (57%), Gaps = 21/152 (13%)

Query: 485 EKRRLAREQREK--EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
           E++RL  EQ+EK  E  + +EQE+++ Q+ +   Q   E++T  +E+E +  + E+ RE+
Sbjct: 656 EQQRLP-EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKT--QEQEKKTWDQEKMREE 712

Query: 543 EEQLQRQAEERALREREEAERAQRQK----EEEARVREEAERVRQEREKHFQRE----EQ 594
           E   +R   E+ +RE EE  R Q +K    EE+   +E+ E + ++ EK +++E    EQ
Sbjct: 713 ESMRER---EKKMREEEEMMREQEEKMQEQEEKM--QEQEEEMWEQEEKMWEQEEKMWEQ 767

Query: 595 ERL-ERKKRL--EEIMKRTRRTEATDKKTSDQ 623
           +RL E+K++L   E M+   +    ++K  DQ
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799



 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 42/155 (27%), Positives = 81/155 (52%), Gaps = 16/155 (10%)

Query: 478 EATRLLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           E  + + E+    REQ EK   +E    EQEE E Q+     QR+ E++    E+E  + 
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ-----QRLPEQKEKLWEQEKMQE 508

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE- 593
           + E+  E+EE+++ Q  E    + ++  R ++ +E+E ++ E+ E++R + +K + +EE 
Sbjct: 509 QEEKIWEQEEKIRDQ--EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 566

Query: 594 -----QERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
                QE+ ++    EE M+   R    +KK  ++
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601



 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 41/147 (27%), Positives = 79/147 (53%), Gaps = 9/147 (6%)

Query: 478 EATRLLAEKRRLAREQREKEE-----RERREQEELERQKREELAQRVAEERTTRREEESR 532
           E    L EK    REQ +  E     RE ++ +E E++ R++  +++ EE   R  E+  
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ-EEKMQEEERIREREKKM 459

Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
           R E E  RE+EE++Q+Q E   + E+EE E  Q++  E+     E E++ QE+E+    +
Sbjct: 460 REEEETMREQEEKMQKQEEN--MWEQEEKEWQQQRLPEQKEKLWEQEKM-QEQEEKIWEQ 516

Query: 593 EQERLERKKRLEEIMKRTRRTEATDKK 619
           E++  ++++   +  K  R+ +  +++
Sbjct: 517 EEKIRDQEEMWGQEKKMWRQEKMREQE 543



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 48/172 (27%), Positives = 89/172 (51%), Gaps = 24/172 (13%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE---ES 531
           + EE  R   EK +   E+ +++E +  EQEE  +++ E++ ++  EE+   +EE   E 
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ--EEKMWEQEEKMWEQ 657

Query: 532 RRL--------------EAEQAREKEEQLQRQAE-ERALREREEAERAQRQKEEEARVRE 576
           +RL              E E+ +E+EE++  Q + E+  +E+E+    Q +  EE  +RE
Sbjct: 658 QRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRE 717

Query: 577 EAERVRQEREKHFQREE--QERLERKKRLEEIM--KRTRRTEATDKKTSDQR 624
             +++R+E E   ++EE  QE+ E+ +  EE M  +  +  E  +K    QR
Sbjct: 718 REKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 38/152 (25%), Positives = 81/152 (53%), Gaps = 8/152 (5%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           EE +    EK+    E+  +E+ E+ +++E + Q++EE    + E+     E+E +  E 
Sbjct: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE---EMWEQEEKMWEQEEKMWEQ 767

Query: 537 EQAREKEEQL---QRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQR 591
           ++  E++E+L   ++  E+  + E+EE  R Q +K   +E ++R + E++R + EK + +
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827

Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           EE+   + +K   +  K   + E  ++K   Q
Sbjct: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQ 859



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 35/128 (27%), Positives = 71/128 (55%), Gaps = 7/128 (5%)

Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAE 537
           E  RL  +K +L   ++ +E+ +  EQEE  R + E++     +E   R +EE  R + E
Sbjct: 766 EQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMR---GQEEKMRGQEEKMRGQEE 822

Query: 538 QAREKEEQLQRQAEERALRER----EEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
           +   +EE++  Q E+   +E     +E +  ++ + +E ++RE+ E++R + EK  ++EE
Sbjct: 823 KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882

Query: 594 QERLERKK 601
           + R + +K
Sbjct: 883 KMRGQEEK 890



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 45/156 (28%), Positives = 78/156 (50%), Gaps = 23/156 (14%)

Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER---------- 523
           T   +A  L   +  +  E+ +K+  E +E+  L   ++ E+   V E +          
Sbjct: 203 TKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLL 262

Query: 524 ----TTRREEESRRLEAEQAREKEEQLQRQAE-----ERALREREEAERAQRQK--EEEA 572
               T   +EE  R E E+ RE+E+++++Q E     E  LRE+E   R Q +K   +E 
Sbjct: 263 PQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321

Query: 573 RVREEAERVR-QEREKHFQREEQERLERKKRLEEIM 607
           R+RE+ + +R QE+E   Q+E +E+ E+ +  EE M
Sbjct: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKM 357



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 47/165 (28%), Positives = 89/165 (53%), Gaps = 27/165 (16%)

Query: 475 DPEEATRLLAEKRRLAREQR-EKEERERREQ------EEL-ERQKREELAQRVAEERTTR 526
           + EE  R   EK +   E   E+EE+E ++Q      E+L E++K +E  +++ E+    
Sbjct: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520

Query: 527 RE------EESRRLEAEQAREKEEQLQRQAE-----ERALREREEAERAQRQKEE----- 570
           R+      +E +    E+ RE+E+Q+  Q E     E+ + ++EE    + Q++E     
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580

Query: 571 -EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
            E ++REE ER+R EREK  + EE+   E++++++E  ++ +  E
Sbjct: 581 QEEKMREE-ERMR-EREKKMREEEEMMREQEEKMQEQEEKMQEQE 623



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 36/152 (23%), Positives = 78/152 (51%), Gaps = 8/152 (5%)

Query: 478 EATRLLAEKRRLAREQREK----EERERREQEELERQKREELAQRVAEERTTRREEESRR 533
           E  + + E+  + REQ EK    EE+ + ++EE+  Q+ +   Q        R  E+  +
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQR 591
           L   +  +++E++  Q E+  +R++EE  R Q +K   +E ++R + E++  + EK + +
Sbjct: 777 LWEHEKMQEQEKIWEQEEK--MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQ 834

Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           EE+   + +K   +  K   + +  ++K  +Q
Sbjct: 835 EEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQ 866



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 40/159 (25%), Positives = 85/159 (53%), Gaps = 12/159 (7%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREEL--AQRVAE------ERTTR 526
           + EE  R   EK +   E+ +++E E  EQEE   ++ E++   QR+ E      E    
Sbjct: 724 EEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 783

Query: 527 REEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQE 584
           +E+E    + E+ R++EE+++ Q E+  +R +EE  R Q +K   +E ++  + E++  +
Sbjct: 784 QEQEKIWEQEEKMRDQEEKMRGQEEK--MRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 841

Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
            EK + +EE+   + + + E++ ++  +    ++K  +Q
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 44/147 (29%), Positives = 80/147 (54%), Gaps = 15/147 (10%)

Query: 483 LAEKRRLAREQREKEERERRE-QEELERQK--REELAQRVAEERTTRREEESRRLEAEQA 539
           L EK  LA  ++ + +   +E + +LER K    ++     +E   R+EEE R  E ++ 
Sbjct: 230 LQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE-KKI 288

Query: 540 REKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREE-QER 596
           R++EE++ RQ E   LRE+E   R Q +K   +E R+RE      QE+E   Q +E +E+
Sbjct: 289 RKQEEKMWRQEER--LREQEGKMREQEEKMWRQEKRLRE------QEKELREQEKELREQ 340

Query: 597 LERKKRLEEIMKRTRRTEATDKKTSDQ 623
            E +++ E++ ++  +    ++K  +Q
Sbjct: 341 KELREQEEQMQEQEEKMWEQEEKMREQ 367



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 8/102 (7%)

Query: 64  DDRQRLARERREEREK-----QLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
           D+R R   ER  E+EK     +    E    E+E++ R   EK  EE + R  E++ +EE
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
                 +E++ Q+ EE+    E    +  ++ + P+QK   W
Sbjct: 463 EETMREQEEKMQKQEENMWEQE---EKEWQQQRLPEQKEKLW 501



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 22/127 (17%)

Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEEL-----ERQKREELAQRVAEERTTRREEE 530
           PE+  +L   ++   +E+  ++E + R+QEE      E+ + +E   R  EE+   +EE+
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830

Query: 531 SRRLEAE----------QAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
               E +          Q  + EE++Q Q E+  +RE+EE  R Q +K     +RE+ E+
Sbjct: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEK--MREQEEKMRGQEEK-----MREQEEK 883

Query: 581 VRQEREK 587
           +R + EK
Sbjct: 884 MRGQEEK 890



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 27/89 (30%), Positives = 49/89 (55%), Gaps = 9/89 (10%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQR 131
           ER  EREK++   E +  E+EE+ ++  EK  E+ +K  E++ + +E+     EEK  ++
Sbjct: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ-----EEKMWEQ 643

Query: 132 LEEDKERHEAVVRRTMERSQKPKQKHNRW 160
            E+  E+ E    +  E+ + P+QK   W
Sbjct: 644 EEKMWEQEE----KMWEQQRLPEQKEKLW 668



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 24/99 (24%), Positives = 57/99 (57%), Gaps = 3/99 (3%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           +++ +   E+ +E+E+++  +E    E+EE+  +  EK  E+ +K  E+QR  E++ +  
Sbjct: 609 EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
             EK +++ E+ +E+ E +  +  E+ +K  Q+  + +W
Sbjct: 669 EHEKMQEQ-EKMQEQEEKIWEQ--EKMEKKTQEQEKKTW 704



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 31/109 (28%), Positives = 60/109 (55%), Gaps = 14/109 (12%)

Query: 65  DRQRLARERRE--EREKQLAAREIVWLEREERARQHYEK------HLEERKKRLEEQRQK 116
           ++++  RE++E  E+E+Q+  +E    E+EE+ R+  EK       L E++K++ EQ QK
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391

Query: 117 ---EERRRAAVEEKRR---QRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              +E R    +E+ R   +R+ E ++  E V +   E+  + ++K  R
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 22/80 (27%), Positives = 45/80 (56%), Gaps = 1/80 (1%)

Query: 64  DDRQRLARERR-EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
           D  +++  E R  EREK++   E    E+EE+ ++  E   E+ +K  ++QR  E++ + 
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500

Query: 123 AVEEKRRQRLEEDKERHEAV 142
             +EK +++ E+  E+ E +
Sbjct: 501 WEQEKMQEQEEKIWEQEEKI 520



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 32/108 (29%), Positives = 51/108 (47%), Gaps = 21/108 (19%)

Query: 72  ERREEREKQLAAR--------EIVWLEREERARQHYEKHLEERK-----------KRLEE 112
           ER  E+EKQ+  +        E +W E++ER R+  E+  E+ K           K+++E
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMW-EQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434

Query: 113 QRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
           Q +K   +   ++E+ R R  E K R E    R  E   + KQ+ N W
Sbjct: 435 QEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQ-KQEENMW 481



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 25/89 (28%), Positives = 51/89 (57%), Gaps = 3/89 (3%)

Query: 66  RQRLARERRE--EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           +QRL  ++ +  E+EK     E +W E+EE+ R   E   +E+K   +E+ +++E +   
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIW-EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE 548

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQK 152
            EEK R + ++  ++ E + ++T E+ +K
Sbjct: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKK 577



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 29/162 (17%), Positives = 67/162 (41%), Gaps = 6/162 (3%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERRRAAV 124
           +RL  + +E RE++   RE   L  +E   Q  E+ +  +E K R +E++   +  R   
Sbjct: 321 KRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 380

Query: 125 EEK----RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
           +EK    + Q++ + +ER      R  E+ ++ +++   W     +     +   +   R
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440

Query: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWE 222
                   +       K++     T+    ++ ++ + + WE
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 482



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 1/86 (1%)

Query: 72  ERREEREKQLAAREIVW-LEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
           E+ +E+EK     E +W  E+ E+  Q  EK   +++K  EE+  +E  ++   EE+  +
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730

Query: 131 RLEEDKERHEAVVRRTMERSQKPKQK 156
             EE  +  E  ++   E   + ++K
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEK 756



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 24/97 (24%), Positives = 54/97 (55%), Gaps = 5/97 (5%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           D  +   +E++  R++++  +E    E+EE+ R   +K + ++++R+E++ Q++E++   
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK-MWDQEERMEKKTQEQEKKTWD 580

Query: 124 VEEKRRQ----RLEEDKERHEAVVRRTMERSQKPKQK 156
            EEK R+    R  E K R E  + R  E   + +++
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 617



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 21/95 (22%), Positives = 48/95 (50%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           ++ D+++   ++ E  EK+   +E    ++EE+ R+       E+K R EE+  +E+  +
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
              +E++ Q  EE     E  ++   E+  + ++K
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 26/98 (26%), Positives = 54/98 (55%), Gaps = 3/98 (3%)

Query: 60  VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ--KE 117
           + + +++     ER  E+E ++  +E     +E+R R+  EK L E++K L EQ++  ++
Sbjct: 288 IRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQ-EKELREQEKELREQKELREQ 346

Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
           E +    EEK  ++ E+ +E+ E + R+     ++ KQ
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 36/157 (22%), Positives = 80/157 (50%), Gaps = 12/157 (7%)

Query: 470 SAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
           SA +T  ++A R + E  +       +  R     EEL++ K  EL +++    + + E 
Sbjct: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKK-KNAELQEKLPLAESEKSEI 244

Query: 530 ESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHF 589
           +    E ++  E+ + L  Q +   L+E        RQ+EE   +RE+ +++R++ EK +
Sbjct: 245 QLNVKELKRKLERAKFLLPQVQTNTLQEE-----MWRQEEE---LREQEKKIRKQEEKMW 296

Query: 590 QREEQERLER---KKRLEEIMKRTRRTEATDKKTSDQ 623
           ++EE+ R +    +++ E++ ++ +R    +K+  +Q
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQ 333



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 28/99 (28%), Positives = 52/99 (52%), Gaps = 9/99 (9%)

Query: 62  RVDDRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
           R+ +R++  RE  E   E+E+++  +E    E+EE+  +  EK  E+ +K  E++ +  E
Sbjct: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649

Query: 119 RRRAAVEEKRRQRLEEDKER---HEAVVRRTMERSQKPK 154
           +     E+   QRL E KE+   HE +  +   + Q+ K
Sbjct: 650 QEEKMWEQ---QRLPEQKEKLWEHEKMQEQEKMQEQEEK 685



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 10/98 (10%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           D  +    E   EREK++   E +  E+EE+ ++  EK  E+     EE+  ++E +   
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ-----EEEMWEQEEKMWE 759

Query: 124 VEEK--RRQRLEEDKER---HEAVVRRTMERSQKPKQK 156
            EEK   +QRL E KE+   HE +  +     Q+ K +
Sbjct: 760 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR 797



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 26/102 (25%), Positives = 52/102 (50%), Gaps = 7/102 (6%)

Query: 65  DRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           +R++  RE  E   E+E+++  +E    E+EE   +  EK  E+ +K  E+QR  E++ +
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776

Query: 122 AAVEEKRRQR----LEEDKERHEAVVRRTMERSQKPKQKHNR 159
               EK +++     +E+K R +    R  E   + +++  R
Sbjct: 777 LWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 28/110 (25%), Positives = 50/110 (45%), Gaps = 15/110 (13%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQH-------------YEKHLEERKKRL 110
           ++  R   E RE+ +K     E +W  +EER R+               EK L E++K L
Sbjct: 272 EEMWRQEEELREQEKKIRKQEEKMW-RQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330

Query: 111 EEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
            EQ +KE R +  + E+  Q  E++++  E   +   +  +  +Q+   W
Sbjct: 331 REQ-EKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 24/94 (25%), Positives = 47/94 (50%), Gaps = 4/94 (4%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           Q    ++ +E+EK+   +E +  E   R R+   +  EE  +  EE+ Q++E +    EE
Sbjct: 689 QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
           +  ++ E+  E+ E    +  E+ + P+QK   W
Sbjct: 749 EMWEQEEKMWEQEE----KMWEQQRLPEQKEKLW 778



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 25/105 (23%), Positives = 53/105 (50%), Gaps = 9/105 (8%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEK-----HLEERKKRLEEQRQKEE 118
           ++  R   E+ +E+E+++  +E    E+EE+  +  EK      L E+K++L E  + +E
Sbjct: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWG 163
           + +   +E++ +  EE     E  +R   E+ +  ++K     WG
Sbjct: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK----MWG 826



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 27/102 (26%), Positives = 55/102 (53%), Gaps = 4/102 (3%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR-LEEQRQKEERR 120
           R ++R R    +  E+E+++  +E    E+E+  R+  ++  E+++ R  EEQ Q++E +
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356

Query: 121 RAAVEEKRRQRLEE---DKERHEAVVRRTMERSQKPKQKHNR 159
               EEK R++ E+    +ER     ++  E+ QK + +  R
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 25/104 (24%), Positives = 52/104 (50%), Gaps = 10/104 (9%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERK--KRLEEQRQKEERRRAAV 124
           +++  E++ + +++    +   ++ EER R+  +K  EE +  +  EE+ QK+E      
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483

Query: 125 EEK--RRQRLEEDK------ERHEAVVRRTMERSQKPKQKHNRW 160
           EEK  ++QRL E K      E+ +    +  E+ +K + +   W
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527



 Score = 37.4 bits (85), Expect = 0.051
 Identities = 23/96 (23%), Positives = 46/96 (47%), Gaps = 9/96 (9%)

Query: 61  LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
           +R  +++   +E R E++ Q         E+E++     EK  EE + R  E++ +EE  
Sbjct: 553 MRDQEQKMWDQEERMEKKTQ---------EQEKKTWDQEEKMREEERMREREKKMREEEE 603

Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
               +E++ Q  EE  +  E  +    E+ Q+ ++K
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 23/114 (20%), Positives = 59/114 (51%), Gaps = 10/114 (8%)

Query: 55  PDPPPVLRVDDRQRLARERREEREKQLAAREIVW-----LEREERARQHYEKHLEERKKR 109
           P+    L   ++ +   E+  E+E+++  +E +W     + R+E+ R+  E  + E++++
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ-EDQMWEQEEK 552

Query: 110 LEEQRQK----EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           + +Q QK    EER     +E+ ++  +++++  E    R  E+  + +++  R
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 20/105 (19%)

Query: 72  ERREEREKQL-------AAREIVWLEREERARQ------------HYEKHLEERKKRLEE 112
           +R+ ER K L         +E +W + EE   Q              E+ L E++ ++ E
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 311

Query: 113 QRQKEERRRAAVEEKRRQRLEEDKE-RHEAVVRRTMERSQKPKQK 156
           Q +K  R+   + E+ ++  E++KE R +  +R   E+ Q+ ++K
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 20/87 (22%), Positives = 46/87 (52%), Gaps = 8/87 (9%)

Query: 75  EEREKQLAAREIVW-----LEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRR 129
           E+ EK     E +W      E++E+  +H +   +E+ +  EE+  ++E+     +E+ +
Sbjct: 642 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK 701

Query: 130 QRLEEDKERHEAVVRRTMERSQKPKQK 156
           +  +++K R E  +R   ER +K +++
Sbjct: 702 KTWDQEKMREEESMR---EREKKMREE 725



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 21/91 (23%), Positives = 47/91 (51%), Gaps = 6/91 (6%)

Query: 72  ERREEREKQLAAREIVW----LEREERARQHYEKHLEERK--KRLEEQRQKEERRRAAVE 125
           E+  E+++    +E +W    ++ +E+ ++  EK  E+ K  K+ +EQ +K   +    E
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE 711

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           E+  +  E+     E ++R   E+ Q+ ++K
Sbjct: 712 EESMREREKKMREEEEMMREQEEKMQEQEEK 742



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 28/113 (24%), Positives = 54/113 (47%), Gaps = 23/113 (20%)

Query: 65  DRQRLARERRE--EREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERR 120
           ++QRL  ++ +  E EK +  +E +W E+EE+ R   EK    EE+ +  EE+ + +E +
Sbjct: 766 EQQRLPEQKEKLWEHEK-MQEQEKIW-EQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK 823

Query: 121 RAAVEEK-----------------RRQRLEEDKERHEAVVRRTMERSQKPKQK 156
               EEK                 + +++EE  +  E  +R   E+ +  ++K
Sbjct: 824 MWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK 876



 Score = 31.2 bits (69), Expect = 3.7
 Identities = 20/79 (25%), Positives = 44/79 (55%), Gaps = 1/79 (1%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           +++ R   E+   +E+++  +E     +EE+     EK  E+ + + E+ R++EE+ R  
Sbjct: 814 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ 873

Query: 124 VEEKRRQRLEEDKERHEAV 142
            EEK R++ E+ + + E +
Sbjct: 874 -EEKMREQEEKMRGQEEKI 891



 Score = 30.4 bits (67), Expect = 6.3
 Identities = 22/92 (23%), Positives = 45/92 (48%), Gaps = 4/92 (4%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERRRAAVEEKRR 129
           E+  ++E+++  +E     +EE+ R   EK    EE+    EE+   +E +    EEK  
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKME 853

Query: 130 QRL--EEDKERHEAVVRRTMERSQKPKQKHNR 159
           +++  +E+K R +    R  E   + +++  R
Sbjct: 854 EKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885



 Score = 30.0 bits (66), Expect = 8.2
 Identities = 20/85 (23%), Positives = 43/85 (50%), Gaps = 3/85 (3%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           +++ R   E+   +E+++  +E     +EE+     EK   + +K  E+ + +EE+ R  
Sbjct: 807 EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMR-- 864

Query: 124 VEEKRRQRLEEDKERHEAVVRRTME 148
            E++ + R +E+K R +    R  E
Sbjct: 865 -EQEEKMRGQEEKMREQEEKMRGQE 888


>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 46/138 (33%), Positives = 88/138 (63%), Gaps = 6/138 (4%)

Query: 489 LAREQREKEER-ERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQ 547
           L ++Q EK  R E + QE+ E+   +EL  R  EE+  R+EE+    E E+ RE+E+++ 
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQE-EKIREQEDKMW 349

Query: 548 RQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREEQERLERKKRLEE 605
           RQ E+  +RE+EE  R Q +K   +E ++RE+ E+++++ E+ +++EE+ R + +KR E+
Sbjct: 350 RQEEK--IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEK 407

Query: 606 IMKRTRRTEATDKKTSDQ 623
           + ++ ++    D+K  +Q
Sbjct: 408 MWRQEKKMREQDEKIREQ 425



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 49/155 (31%), Positives = 92/155 (59%), Gaps = 14/155 (9%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL---AQRVAEERTTR-----RE 528
           EE  R   EK R   E+  ++E + REQ+E  +++ EE+    +++ E+   R     R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411

Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQERE 586
           E+  R + E+ RE+EE++ RQ E+  +RE EE  + Q +K  E E +++EE E+++++ E
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEK--IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469

Query: 587 KHFQREE--QERLERKKRLEEIMKRTRRTEATDKK 619
           K  ++EE  QE+ E+  R E+++K+  +    ++K
Sbjct: 470 KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 48/142 (33%), Positives = 86/142 (60%), Gaps = 11/142 (7%)

Query: 477 EEATRLLAEKRRLAREQREKEERER----REQEE---LERQKREELAQRVAEERTTRRE- 528
           EE  R   EKR+    ++EK+ RE+    REQEE    + +K  EL + + ++    RE 
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453

Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKH 588
           EE  + E E+ +E+EE++QRQ EE+   + E+  R ++  ++E ++ E+ E++ ++ EK 
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQ-EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512

Query: 589 FQREE--QERLERKKRLEEIMK 608
           +++EE  QE+ E+ +R EE M+
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMR 534



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 40/137 (29%), Positives = 85/137 (62%), Gaps = 12/137 (8%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E+  ++  ++ ++ R++ +  E+E + +E+ ++  R+E   R  EE+   +EE+  R E 
Sbjct: 315 EQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE- 373

Query: 537 EQAREKEEQLQRQAEE-----RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
           E+ RE++E++Q Q EE       +RE+EE +R ++   +E ++RE+ E++R++ E+ +++
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEE-KRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432

Query: 592 EEQERLERKKRLEEIMK 608
           EE+ R      LEE+M+
Sbjct: 433 EEKIR-----ELEEMMQ 444



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 43/151 (28%), Positives = 86/151 (56%), Gaps = 5/151 (3%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQK--REELAQRVAEERTTRREEESRRL 534
           EE  R   EK +   E+  ++E + REQEE  ++K  R+E   R  +E+   +EEE  R 
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
           E E+ RE EE +Q Q E+    E +  E  ++ +E+E +++ + E+++++ EK +++E+ 
Sbjct: 433 E-EKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491

Query: 595 ERLERK--KRLEEIMKRTRRTEATDKKTSDQ 623
            + E K  ++ E++ ++  +    ++K  +Q
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQ 522



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 38/141 (26%), Positives = 82/141 (58%), Gaps = 4/141 (2%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E+  ++  ++ ++ R++ +  E+E + +E+ E+  R+E   R  +E+   +EEE  R E 
Sbjct: 336 EQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE- 394

Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE---EAERVRQEREKHFQREE 593
           E+ RE+EE+ Q +   +  + RE+ E+ + Q+EE  R  E   E E + Q++E+  +  E
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454

Query: 594 QERLERKKRLEEIMKRTRRTE 614
           ++  E +++++E  ++ +R E
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQE 475



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 35/138 (25%), Positives = 79/138 (57%), Gaps = 4/138 (2%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEEL---ERQKREELAQRVAEERTTRREEES 531
           + EE      EK R   E  + +E + RE EE    E +K +E  +++  +    +E+E 
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEE 483

Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
           +    E+  ++EE++  Q E+   +E +  E+ ++ +E+E +++ + E++R++  + +Q+
Sbjct: 484 KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543

Query: 592 EEQERLERKKRLEEIMKR 609
           EE+ + E++ RL+E+ +R
Sbjct: 544 EEKMQ-EQEVRLQELEER 560



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 41/150 (27%), Positives = 85/150 (56%), Gaps = 12/150 (8%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           D EE  R + EK       +E+EE+ + ++E+++RQ+ +   Q   EE+T R+E+  +  
Sbjct: 445 DQEEKLREVEEK------MQEEEEKMQEQEEKIQRQEEKIQEQ---EEKTWRQEKLLK-- 493

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
           + E+  E+EE++ RQ E+   +E +  E+ ++ + +E ++RE+  R+ Q+ EK  Q +E 
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK-MQEQEV 552

Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
              E ++RL ++ ++        +++  QR
Sbjct: 553 RLQELEERLGKLGQKAELLGGAGRESGSQR 582



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 44/152 (28%), Positives = 84/152 (55%), Gaps = 14/152 (9%)

Query: 481 RLLAEKRRLAREQREKEERERREQEELE-----RQKREELAQRVAEERTTRREEESRRLE 535
           +L  E  RL +E +    + + + EE E      Q++EE   R  E+    +E+E +  E
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKI---QEQEEKMCE 315

Query: 536 AE-QAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQRE 592
            E + RE+EE++ RQ E+  + E+EE  R Q  K   +E ++RE+ E++R++ EK   R+
Sbjct: 316 QELKIREQEEKMWRQEEK--MHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK-MWRQ 372

Query: 593 EQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           E++  E+ ++++E  +   R E   ++  ++R
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKR 404



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 41/166 (24%), Positives = 87/166 (52%), Gaps = 22/166 (13%)

Query: 477 EEATRLL-AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
           +E  RL+ +EK  +    ++ + +  R Q  L +Q+ +  A R+ +E  +   +   ++E
Sbjct: 224 QEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE 283

Query: 536 AEQA-----REKEEQLQRQAE----------ERALREREEAERAQRQKEEEARVREEAER 580
             +      +++EE++ RQ E          E+ L+ RE+ E+  RQ+E   ++ E+ E+
Sbjct: 284 ENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEE---KMHEQEEK 340

Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE---ATDKKTSDQ 623
           +R++ +K +++EE+ R + +K  E+  K  R+ E     D+K  +Q
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ 386



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 4/120 (3%)

Query: 60  VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
           + R +++ +   E+   +EK L   E +W + E+  RQ  E+ + E++++++EQ +K +R
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ--EEKMWEQEEKMQEQEEKMQR 528

Query: 120 RRAAVEEK--RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADP 177
           +   + E+  R  + EE  +  E  ++   ER  K  QK       G   GS  + +  P
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP 588



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 22/86 (25%), Positives = 48/86 (55%), Gaps = 1/86 (1%)

Query: 72  ERREEREKQLAAREIVWLEREERA-RQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
           E+ +E+E+++  +E+   E+EE+  RQ  + H +E K R +E +   +  +   +E++ +
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363

Query: 131 RLEEDKERHEAVVRRTMERSQKPKQK 156
             EE   R E  +R   E+ Q+ +++
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEE 389



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 28/102 (27%), Positives = 56/102 (54%), Gaps = 12/102 (11%)

Query: 71  RERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRRAAVEEKR 128
           RE+ E+R++++  +E    E++E+ R+  E+    EE+ + LEE  Q +E +   VEEK 
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457

Query: 129 RQ-----RLEEDK-ERHEAVVRRTMERSQKP----KQKHNRW 160
           ++     + +E+K +R E  ++   E++ +     KQ+   W
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 26/102 (25%), Positives = 54/102 (52%), Gaps = 3/102 (2%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEER 119
           R +++     E+  E+E ++  +E    E+EE+ R+  EK    EE+ +  +E+ Q++E 
Sbjct: 329 RQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE 388

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK-PKQKHNRW 160
                EEK R++ E+ +E+     ++  E+ +K  +Q+   W
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMW 430



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 26/98 (26%), Positives = 53/98 (54%), Gaps = 5/98 (5%)

Query: 62  RVDDRQRLARERREE---REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
           ++ +++   RE+ E+   +E+++  ++    E+EE   +  EK  E+ +KR E+  ++E+
Sbjct: 354 KIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEK 413

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           + R   E+ R Q  EE+  R E  +R   E  Q  ++K
Sbjct: 414 KMREQDEKIREQ--EEEMWRQEEKIRELEEMMQDQEEK 449



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 27/94 (28%), Positives = 51/94 (54%), Gaps = 11/94 (11%)

Query: 73  RREEREKQLAAR--EIVW------LEREERARQHYEK--HLEERKKRLEEQRQKEERRRA 122
           R+EE+ ++   +  E +W       E++E+ R+  E+    EE+ + LEE  Q +E +  
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLR 451

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            VEEK ++  EE  +  E  ++R  E+ Q+ ++K
Sbjct: 452 EVEEKMQEE-EEKMQEQEEKIQRQEEKIQEQEEK 484



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 36/181 (19%), Positives = 79/181 (43%), Gaps = 43/181 (23%)

Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR 533
           T   +A  L   +  +  E+ +++  E +E+  L   ++ E+   V + +        R+
Sbjct: 196 TKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLK--------RK 247

Query: 534 LEAEQAREKEEQLQ-------------------------------RQAEERALREREE-A 561
           LE  Q    ++QLQ                               +Q EE+  R+ E+  
Sbjct: 248 LERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ 307

Query: 562 ERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKK---RLEEIMKRTRRTEATDK 618
           E+ ++  E+E ++RE+ E++ ++ EK  ++EE+ R +  K   + E+I ++  +    ++
Sbjct: 308 EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEE 367

Query: 619 K 619
           K
Sbjct: 368 K 368



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 27/118 (22%), Positives = 59/118 (50%), Gaps = 10/118 (8%)

Query: 53  NKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEK---------HL 103
           N+     + R +++ +   E+  E+E ++  +E     +EE+  +  EK           
Sbjct: 292 NQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQ 351

Query: 104 EERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTME-RSQKPKQKHNRW 160
           EE+ +  EE+ +++E +    EEK R++ E+ +E+ E + R+  + R Q+ K++   W
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 28/91 (30%), Positives = 49/91 (53%), Gaps = 12/91 (13%)

Query: 74  REEREKQLAAREIVWLEREERARQHYEKHLEE---RKKRLEEQ-----RQKEERRRAAVE 125
           RE+ EK     E +W  +EE+ R+  EK  E+   ++K++ EQ      Q+EE  R   +
Sbjct: 377 REQDEKIQEQEEEMW-RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR---Q 432

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           E++ + LEE  +  E  +R   E+ Q+ ++K
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 20/94 (21%), Positives = 49/94 (52%)

Query: 63  VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
           V+++ +   E+ +E+E+++  +E    E+EE+  +  +   +E K   +E++   +  + 
Sbjct: 453 VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             +E++ Q  EE  +R E  +R    R  + ++K
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK 546



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 26/89 (29%), Positives = 52/89 (58%), Gaps = 9/89 (10%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL----EEQRQKEER 119
           D   R   + RE+ EK     E +W  +EE+ R+  EK ++E+++ +    E+ R++EE+
Sbjct: 346 DKMWRQEEKIREQEEKIREQEEKMW-RQEEKIREQDEK-IQEQEEEMWRQEEKIREQEEK 403

Query: 120 RRAAV---EEKRRQRLEEDKERHEAVVRR 145
           R+  +   E+K R++ E+ +E+ E + R+
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQ 432



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 19/90 (21%), Positives = 44/90 (48%), Gaps = 8/90 (8%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           + +  + +EE EK          E+EE+ ++  EK  E+ +K   +++  ++  +   +E
Sbjct: 451 REVEEKMQEEEEKM--------QEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQE 502

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           ++  R EE     E  ++   E+ Q+ ++K
Sbjct: 503 EKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532


>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
           member 6-like protein 6 [Homo sapiens]
          Length = 655

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 46/138 (33%), Positives = 88/138 (63%), Gaps = 6/138 (4%)

Query: 489 LAREQREKEER-ERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQ 547
           L ++Q EK  R E + QE+ E+   +EL  R  EE+  R+EE+    E E+ RE+E+++ 
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQE-EKIREQEDKMW 349

Query: 548 RQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREEQERLERKKRLEE 605
           RQ E+  +RE+EE  R Q +K   +E ++RE+ E+++++ E+ +++EE+ R + +KR E+
Sbjct: 350 RQEEK--IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEK 407

Query: 606 IMKRTRRTEATDKKTSDQ 623
           + ++ ++    D+K  +Q
Sbjct: 408 MWRQEKKMREQDEKIREQ 425



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 49/155 (31%), Positives = 92/155 (59%), Gaps = 14/155 (9%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL---AQRVAEERTTR-----RE 528
           EE  R   EK R   E+  ++E + REQ+E  +++ EE+    +++ E+   R     R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411

Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQERE 586
           E+  R + E+ RE+EE++ RQ E+  +RE EE  + Q +K  E E +++EE E+++++ E
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEK--IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469

Query: 587 KHFQREE--QERLERKKRLEEIMKRTRRTEATDKK 619
           K  ++EE  QE+ E+  R E+++K+  +    ++K
Sbjct: 470 KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 48/142 (33%), Positives = 86/142 (60%), Gaps = 11/142 (7%)

Query: 477 EEATRLLAEKRRLAREQREKEERER----REQEE---LERQKREELAQRVAEERTTRRE- 528
           EE  R   EKR+    ++EK+ RE+    REQEE    + +K  EL + + ++    RE 
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453

Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKH 588
           EE  + E E+ +E+EE++QRQ EE+   + E+  R ++  ++E ++ E+ E++ ++ EK 
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQ-EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512

Query: 589 FQREE--QERLERKKRLEEIMK 608
           +++EE  QE+ E+ +R EE M+
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMR 534



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 40/137 (29%), Positives = 85/137 (62%), Gaps = 12/137 (8%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E+  ++  ++ ++ R++ +  E+E + +E+ ++  R+E   R  EE+   +EE+  R E 
Sbjct: 315 EQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE- 373

Query: 537 EQAREKEEQLQRQAEE-----RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
           E+ RE++E++Q Q EE       +RE+EE +R ++   +E ++RE+ E++R++ E+ +++
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEE-KRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432

Query: 592 EEQERLERKKRLEEIMK 608
           EE+ R      LEE+M+
Sbjct: 433 EEKIR-----ELEEMMQ 444



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 43/151 (28%), Positives = 86/151 (56%), Gaps = 5/151 (3%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQK--REELAQRVAEERTTRREEESRRL 534
           EE  R   EK +   E+  ++E + REQEE  ++K  R+E   R  +E+   +EEE  R 
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
           E E+ RE EE +Q Q E+    E +  E  ++ +E+E +++ + E+++++ EK +++E+ 
Sbjct: 433 E-EKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491

Query: 595 ERLERK--KRLEEIMKRTRRTEATDKKTSDQ 623
            + E K  ++ E++ ++  +    ++K  +Q
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQ 522



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 38/141 (26%), Positives = 82/141 (58%), Gaps = 4/141 (2%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E+  ++  ++ ++ R++ +  E+E + +E+ E+  R+E   R  +E+   +EEE  R E 
Sbjct: 336 EQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE- 394

Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE---EAERVRQEREKHFQREE 593
           E+ RE+EE+ Q +   +  + RE+ E+ + Q+EE  R  E   E E + Q++E+  +  E
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454

Query: 594 QERLERKKRLEEIMKRTRRTE 614
           ++  E +++++E  ++ +R E
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQE 475



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 35/138 (25%), Positives = 79/138 (57%), Gaps = 4/138 (2%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEEL---ERQKREELAQRVAEERTTRREEES 531
           + EE      EK R   E  + +E + RE EE    E +K +E  +++  +    +E+E 
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEE 483

Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
           +    E+  ++EE++  Q E+   +E +  E+ ++ +E+E +++ + E++R++  + +Q+
Sbjct: 484 KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543

Query: 592 EEQERLERKKRLEEIMKR 609
           EE+ + E++ RL+E+ +R
Sbjct: 544 EEKMQ-EQEVRLQELEER 560



 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 41/150 (27%), Positives = 85/150 (56%), Gaps = 12/150 (8%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           D EE  R + EK       +E+EE+ + ++E+++RQ+ +   Q   EE+T R+E+  +  
Sbjct: 445 DQEEKLREVEEK------MQEEEEKMQEQEEKIQRQEEKIQEQ---EEKTWRQEKLLK-- 493

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
           + E+  E+EE++ RQ E+   +E +  E+ ++ + +E ++RE+  R+ Q+ EK  Q +E 
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK-MQEQEV 552

Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
              E ++RL ++ ++        +++  QR
Sbjct: 553 RLQELEERLGKLGQKAELLGGAGRESGSQR 582



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 44/152 (28%), Positives = 84/152 (55%), Gaps = 14/152 (9%)

Query: 481 RLLAEKRRLAREQREKEERERREQEELE-----RQKREELAQRVAEERTTRREEESRRLE 535
           +L  E  RL +E +    + + + EE E      Q++EE   R  E+    +E+E +  E
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKI---QEQEEKMCE 315

Query: 536 AE-QAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQRE 592
            E + RE+EE++ RQ E+  + E+EE  R Q  K   +E ++RE+ E++R++ EK   R+
Sbjct: 316 QELKIREQEEKMWRQEEK--MHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK-MWRQ 372

Query: 593 EQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           E++  E+ ++++E  +   R E   ++  ++R
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKR 404



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 41/166 (24%), Positives = 87/166 (52%), Gaps = 22/166 (13%)

Query: 477 EEATRLL-AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
           +E  RL+ +EK  +    ++ + +  R Q  L +Q+ +  A R+ +E  +   +   ++E
Sbjct: 224 QEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE 283

Query: 536 AEQA-----REKEEQLQRQAE----------ERALREREEAERAQRQKEEEARVREEAER 580
             +      +++EE++ RQ E          E+ L+ RE+ E+  RQ+E   ++ E+ E+
Sbjct: 284 ENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEE---KMHEQEEK 340

Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE---ATDKKTSDQ 623
           +R++ +K +++EE+ R + +K  E+  K  R+ E     D+K  +Q
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ 386



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 4/120 (3%)

Query: 60  VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
           + R +++ +   E+   +EK L   E +W + E+  RQ  E+ + E++++++EQ +K +R
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ--EEKMWEQEEKMQEQEEKMQR 528

Query: 120 RRAAVEEK--RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADP 177
           +   + E+  R  + EE  +  E  ++   ER  K  QK       G   GS  + +  P
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP 588



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 22/86 (25%), Positives = 48/86 (55%), Gaps = 1/86 (1%)

Query: 72  ERREEREKQLAAREIVWLEREERA-RQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
           E+ +E+E+++  +E+   E+EE+  RQ  + H +E K R +E +   +  +   +E++ +
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363

Query: 131 RLEEDKERHEAVVRRTMERSQKPKQK 156
             EE   R E  +R   E+ Q+ +++
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEE 389



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 28/102 (27%), Positives = 56/102 (54%), Gaps = 12/102 (11%)

Query: 71  RERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRRAAVEEKR 128
           RE+ E+R++++  +E    E++E+ R+  E+    EE+ + LEE  Q +E +   VEEK 
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457

Query: 129 RQ-----RLEEDK-ERHEAVVRRTMERSQKP----KQKHNRW 160
           ++     + +E+K +R E  ++   E++ +     KQ+   W
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 26/102 (25%), Positives = 54/102 (52%), Gaps = 3/102 (2%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEER 119
           R +++     E+  E+E ++  +E    E+EE+ R+  EK    EE+ +  +E+ Q++E 
Sbjct: 329 RQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE 388

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK-PKQKHNRW 160
                EEK R++ E+ +E+     ++  E+ +K  +Q+   W
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMW 430



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 26/98 (26%), Positives = 53/98 (54%), Gaps = 5/98 (5%)

Query: 62  RVDDRQRLARERREE---REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
           ++ +++   RE+ E+   +E+++  ++    E+EE   +  EK  E+ +KR E+  ++E+
Sbjct: 354 KIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEK 413

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           + R   E+ R Q  EE+  R E  +R   E  Q  ++K
Sbjct: 414 KMREQDEKIREQ--EEEMWRQEEKIRELEEMMQDQEEK 449



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 27/94 (28%), Positives = 51/94 (54%), Gaps = 11/94 (11%)

Query: 73  RREEREKQLAAR--EIVW------LEREERARQHYEK--HLEERKKRLEEQRQKEERRRA 122
           R+EE+ ++   +  E +W       E++E+ R+  E+    EE+ + LEE  Q +E +  
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLR 451

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            VEEK ++  EE  +  E  ++R  E+ Q+ ++K
Sbjct: 452 EVEEKMQEE-EEKMQEQEEKIQRQEEKIQEQEEK 484



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 37/175 (21%), Positives = 77/175 (44%), Gaps = 36/175 (20%)

Query: 481 RLLAEKRRLARE-QREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQA 539
           +L  E+  L+ E  R     E  +++  E Q++  L +    E     ++  R+LE  Q 
Sbjct: 194 KLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQL 253

Query: 540 REKEEQLQ-------------------------------RQAEERALREREE-AERAQRQ 567
              ++QLQ                               +Q EE+  R+ E+  E+ ++ 
Sbjct: 254 LLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKM 313

Query: 568 KEEEARVREEAERVRQEREKHFQREEQERLERKK---RLEEIMKRTRRTEATDKK 619
            E+E ++RE+ E++ ++ EK  ++EE+ R +  K   + E+I ++  +    ++K
Sbjct: 314 CEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK 368



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 27/118 (22%), Positives = 59/118 (50%), Gaps = 10/118 (8%)

Query: 53  NKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEK---------HL 103
           N+     + R +++ +   E+  E+E ++  +E     +EE+  +  EK           
Sbjct: 292 NQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQ 351

Query: 104 EERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTME-RSQKPKQKHNRW 160
           EE+ +  EE+ +++E +    EEK R++ E+ +E+ E + R+  + R Q+ K++   W
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 28/91 (30%), Positives = 49/91 (53%), Gaps = 12/91 (13%)

Query: 74  REEREKQLAAREIVWLEREERARQHYEKHLEE---RKKRLEEQ-----RQKEERRRAAVE 125
           RE+ EK     E +W  +EE+ R+  EK  E+   ++K++ EQ      Q+EE  R   +
Sbjct: 377 REQDEKIQEQEEEMW-RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR---Q 432

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           E++ + LEE  +  E  +R   E+ Q+ ++K
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 20/94 (21%), Positives = 49/94 (52%)

Query: 63  VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
           V+++ +   E+ +E+E+++  +E    E+EE+  +  +   +E K   +E++   +  + 
Sbjct: 453 VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             +E++ Q  EE  +R E  +R    R  + ++K
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK 546



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 26/89 (29%), Positives = 52/89 (58%), Gaps = 9/89 (10%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL----EEQRQKEER 119
           D   R   + RE+ EK     E +W  +EE+ R+  EK ++E+++ +    E+ R++EE+
Sbjct: 346 DKMWRQEEKIREQEEKIREQEEKMW-RQEEKIREQDEK-IQEQEEEMWRQEEKIREQEEK 403

Query: 120 RRAAV---EEKRRQRLEEDKERHEAVVRR 145
           R+  +   E+K R++ E+ +E+ E + R+
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQ 432



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 19/90 (21%), Positives = 44/90 (48%), Gaps = 8/90 (8%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
           + +  + +EE EK          E+EE+ ++  EK  E+ +K   +++  ++  +   +E
Sbjct: 451 REVEEKMQEEEEKM--------QEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQE 502

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           ++  R EE     E  ++   E+ Q+ ++K
Sbjct: 503 EKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532


>gi|7661936 scaffold attachment factor B2 [Homo sapiens]
          Length = 953

 Score = 77.0 bits (188), Expect = 6e-14
 Identities = 69/249 (27%), Positives = 114/249 (45%), Gaps = 35/249 (14%)

Query: 372 VKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAP 431
           +K+E K+E   K  EK+P+ +             K EE   +E  P     GP   +   
Sbjct: 523 IKKEEKIE---KKEEKKPEDI-------------KKEEKDQDELKP-----GPTNRSRVT 561

Query: 432 APASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAR 491
              S     +         P +     S    S S + S+ + D +  ++   EKR +  
Sbjct: 562 KSGSRGMERTVVMDKSKGEPVI-----SVKTTSRSKERSSKSQDRKSESK---EKRDILS 613

Query: 492 EQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAE 551
             + KE+RER  Q + ER+ RE   +R  E+R     E  +RLEA   R+++ +LQR+  
Sbjct: 614 FDKIKEQRERERQRQREREIRETERRREREQR-----EREQRLEAFHERKEKARLQRERL 668

Query: 552 E-RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRT 610
           +    R+R E ER +R++ E  R+R E ER +++   H +REE  R + + R E+  +  
Sbjct: 669 QLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPG 728

Query: 611 RRTEATDKK 619
           RR    D++
Sbjct: 729 RRPYDLDRR 737



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 40/154 (25%), Positives = 73/154 (47%), Gaps = 7/154 (4%)

Query: 10  GHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRL 69
           G RG +  V  + +     +  K  + S+  S+ S    + S  K D     ++ +++  
Sbjct: 564 GSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRER 623

Query: 70  ARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE----RRRAAVE 125
            R+R+ ERE +   R     ERE+R R+   +   ERK++   QR++ +    R+R   E
Sbjct: 624 ERQRQREREIRETERR---REREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERE 680

Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              R+RLE ++ R E   R+  ER  + +++  R
Sbjct: 681 RMERERLERERMRVERERRKEQERIHREREELRR 714



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 42/140 (30%), Positives = 69/140 (49%), Gaps = 15/140 (10%)

Query: 20  SETAPDSYKVQDKKNASSRPASAISG---QNNNHSGNKPDPPPVLRVDDRQRLARERREE 76
           S +   S K QD+K+ S      +S    +       +      +R  +R+R  RE+R E
Sbjct: 589 SRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRR-EREQR-E 646

Query: 77  REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDK 136
           RE++L A    + ER+E+AR      L+  + +LE QRQ+ ER R   E   R+R+  ++
Sbjct: 647 REQRLEA----FHERKEKAR------LQRERLQLECQRQRLERERMERERLERERMRVER 696

Query: 137 ERHEAVVRRTMERSQKPKQK 156
           ER +   R   ER +  +Q+
Sbjct: 697 ERRKEQERIHREREELRRQQ 716



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 37/159 (23%), Positives = 71/159 (44%), Gaps = 19/159 (11%)

Query: 19  RSETAPDSYKVQDKKNASSRPA---------SAISGQNNNHSGNKPDPPPVLRVD----- 64
           + E  P+  K ++K     +P          S   G       +K    PV+ V      
Sbjct: 532 KEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRS 591

Query: 65  -DRQRLARERREEREKQ---LAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
            +R   +++R+ E +++   L+  +I      ER RQ   +  E  ++R  EQR++E+R 
Sbjct: 592 KERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRL 651

Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            A  E K + RL+ ++ + E   R+ +ER +  +++  R
Sbjct: 652 EAFHERKEKARLQRERLQLEC-QRQRLERERMERERLER 689



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 23/80 (28%), Positives = 44/80 (55%), Gaps = 4/80 (5%)

Query: 65  DRQRLARERRE-EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           ++ RL RER + E ++Q   RE +  ER ER R   E+   + ++R+  +R++  R++  
Sbjct: 659 EKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQ 718

Query: 124 V---EEKRRQRLEEDKERHE 140
           +   +E+R  R   D +R +
Sbjct: 719 LRYEQERRPGRRPYDLDRRD 738



 Score = 31.6 bits (70), Expect = 2.8
 Identities = 19/70 (27%), Positives = 33/70 (47%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           +R+RL RER     ++   +E +  EREE  RQ  +   E+ ++        + R  A  
Sbjct: 683 ERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYW 742

Query: 125 EEKRRQRLEE 134
            E +R  +E+
Sbjct: 743 PEGKRVAMED 752


>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
           sapiens]
          Length = 956

 Score = 76.6 bits (187), Expect = 8e-14
 Identities = 56/186 (30%), Positives = 96/186 (51%), Gaps = 20/186 (10%)

Query: 409 EATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVK 468
           E+ V E  P E  V   + +   +P+S  +P   PAP P    +    P+ST     + K
Sbjct: 268 ESEVLESFPEEDSV--LSHSSLSSPSSTSSPEGPPAP-PKQHSSTSPFPTSTPLRRITKK 324

Query: 469 TSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRRE 528
              G+T+  +  RL  ++ RL ++ + + ERE       E++K +E A+R  EE   ++E
Sbjct: 325 FVKGSTEKNKL-RLQRDQERLGKQLKLRAERE-------EKEKLKEEAKRAKEEAKKKKE 376

Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQ---------RQKEEEARVREEAE 579
           EE    E E+  ++E+  + +AE++ L+E    ER +         R+KEEE R+REE +
Sbjct: 377 EEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEK 436

Query: 580 RVRQER 585
           R++ E+
Sbjct: 437 RIKAEK 442



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 12/212 (5%)

Query: 399 KGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPS 458
           KG+ P+V +++       P + +  PA P        +    S P    V + + +S+PS
Sbjct: 234 KGKVPMVVLQDILAVR--PPQIKSLPATPQGKNMTPESEVLESFPEEDSVLSHSSLSSPS 291

Query: 459 STVNAS---ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEE-RERREQEELERQKREE 514
           ST +     A  K  + T+    +T L    ++  +   EK + R +R+QE L +Q    
Sbjct: 292 STSSPEGPPAPPKQHSSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQ---- 347

Query: 515 LAQRVAEERTTRREEESRRLEAEQAREKEEQLQ-RQAEERALREREEAERAQRQKEEEAR 573
           L  R   E   + +EE++R + E  ++KEE+ + ++ E R  RE++E E+A++Q+ +E R
Sbjct: 348 LKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEER 407

Query: 574 VREEAERVRQEREKHFQREEQERL-ERKKRLE 604
            +E  E +  + E+  ++EE++RL E +KR++
Sbjct: 408 RKERQEALEAKLEEKRKKEEEKRLREEEKRIK 439



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 32/98 (32%), Positives = 58/98 (59%), Gaps = 8/98 (8%)

Query: 65  DRQRLARE---RREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           D++RL ++   R E  EK+    E    + E + ++  EK L+E+++R  E+R+K+E+ +
Sbjct: 340 DQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERR--EKREKDEKEK 397

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           A   EK+R + E  KER EA+  +  E+ +K ++K  R
Sbjct: 398 A---EKQRLKEERRKERQEALEAKLEEKRKKEEEKRLR 432



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 31/102 (30%), Positives = 57/102 (55%), Gaps = 14/102 (13%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR-- 121
           +++++L  E +  +E+    +E    E+E + ++  EK  ++ K++ E+QR KEERR+  
Sbjct: 355 EEKEKLKEEAKRAKEEAKKKKEE---EKELKEKERREKREKDEKEKAEKQRLKEERRKER 411

Query: 122 -----AAVEEKRR----QRLEEDKERHEAVVRRTMERSQKPK 154
                A +EEKR+    +RL E+++R +A         QKPK
Sbjct: 412 QEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPK 453



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 23/76 (30%), Positives = 45/76 (59%)

Query: 66  RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
           +++  RE+RE+ EK+ A ++ +  ER +  ++  E  LEE++K+ EE+R +EE +R   E
Sbjct: 382 KEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAE 441

Query: 126 EKRRQRLEEDKERHEA 141
           +    R  +  +  +A
Sbjct: 442 KAEITRFFQKPKTPQA 457


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 43/144 (29%), Positives = 76/144 (52%), Gaps = 8/144 (5%)

Query: 485 EKRRLAREQREKE-ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKE 543
           E++R     R+KE ERE+  QE  ER+++ E   +  +  + R  E  R  E E   E++
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225

Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ---EREKHFQREEQERLERK 600
            Q  R+ + +   ERE  ++A+R++  E     + ER R+   +R++  +++E+ER   +
Sbjct: 226 RQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR 285

Query: 601 KRLEEIMKRTRRTEATDKKTSDQR 624
           KR     +RT R   T++K   QR
Sbjct: 286 KR----QRRTERDRETERKRERQR 305



 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 43/129 (33%), Positives = 70/129 (54%), Gaps = 7/129 (5%)

Query: 492 EQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAE------QAREKEEQ 545
           E++ + +RER  Q + ER++ ++  +  A ER T R++E  R          + +E+E Q
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQ 282

Query: 546 LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEE 605
             R+ + R  R+RE   + +RQ+E E R RE   +  +ERE+  +RE Q   ER +  E 
Sbjct: 283 TDRKRQRRTERDRETERKRERQRERE-RERERNRKRERERERERERERQRETERDREKER 341

Query: 606 IMKRTRRTE 614
             KR R+TE
Sbjct: 342 ERKRKRQTE 350



 Score = 73.9 bits (180), Expect = 5e-13
 Identities = 50/146 (34%), Positives = 77/146 (52%), Gaps = 7/146 (4%)

Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAE 537
           E  R    +R   RE+  K ERER  + E ERQ+  E  +    ER  +R+ E   ++ E
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTE---MDRE 354

Query: 538 QAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE---EAERVRQ-EREKHFQREE 593
           + R+   + +RQAE    RERE   ++ R++EE  R R+   + ER RQ E+++  QRE 
Sbjct: 355 RNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRET 414

Query: 594 QERLERKKRLEEIMKRTRRTEATDKK 619
           +++ ER+K  E    R R  E   +K
Sbjct: 415 EKQREREKDRESERGRERGREREKQK 440



 Score = 73.2 bits (178), Expect = 8e-13
 Identities = 47/156 (30%), Positives = 79/156 (50%), Gaps = 12/156 (7%)

Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEE---SRRL 534
           E  R     R   R++  ++ERER+   E +RQ+ +E  ++   ER T RE E    R+ 
Sbjct: 84  EKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
           + ++ RE++   +++ E +  RER+      RQKE E   RE+  + R+ERE+  ++E +
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQRQTERNRQKERE---REKNRQERRERERQREKENK 200

Query: 595 ------ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
                 ER   ++R  E    T R   TD++   QR
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRERDRQR 236



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 43/144 (29%), Positives = 78/144 (54%), Gaps = 7/144 (4%)

Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK--E 543
           +R+  RE+  + E+ER  Q+E ER+   E  +R  + +T  + E  R+ +AE+ RE+  +
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETERE-GERGRDRQTDGQRERERQRDAEKERERQTD 164

Query: 544 EQLQRQAEERALRERE----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
            + QRQ E    +ERE      ER +R+++ E   + E     + RE+  +RE +   ER
Sbjct: 165 RERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETER 224

Query: 600 KKRLEEIMKRTRRTEATDKKTSDQ 623
           K++ +    R R+TE   +K +++
Sbjct: 225 KRQTDRERDRQRKTEREREKQAER 248



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 45/138 (32%), Positives = 74/138 (53%), Gaps = 9/138 (6%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAE---ERTTRREEES---RRLEAEQ 538
           E+ R    +REK  +ERRE+E  +R+K  +   R +E   ER   RE E+   R+ + ++
Sbjct: 172 ERNRQKEREREKNRQERRERER-QREKENKTEDRHSERGRERERERETETETERKRQTDR 230

Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR--QEREKHFQREEQER 596
            R+++ + +R+ E++A RER      +R KE E     + +R R  +ERE+   R+ Q R
Sbjct: 231 ERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRR 290

Query: 597 LERKKRLEEIMKRTRRTE 614
            ER +  E   +R R  E
Sbjct: 291 TERDRETERKRERQRERE 308



 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 40/146 (27%), Positives = 75/146 (51%), Gaps = 2/146 (1%)

Query: 484 AEKRRLAREQREK-EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
           AE+ R +  + E+ +ERER    + +R +R++  +R  + +  RR E  R  E ++ R++
Sbjct: 246 AERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQR 305

Query: 543 EEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR-QEREKHFQREEQERLERKK 601
           E + +R+   +  RERE     +RQ+E E    +E ER R ++ E   +R  Q   E ++
Sbjct: 306 ERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR 365

Query: 602 RLEEIMKRTRRTEATDKKTSDQRNGD 627
           + E   +R R  +    +  ++R  D
Sbjct: 366 QAERERERERERDRQSAREREERERD 391



 Score = 70.9 bits (172), Expect = 4e-12
 Identities = 47/156 (30%), Positives = 79/156 (50%), Gaps = 16/156 (10%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEE-----SRRLEAEQA 539
           E+ R     R++ ++ER  Q + +RQ+R E  +    +R  +RE E     +R+ E E+ 
Sbjct: 263 ERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERE 322

Query: 540 REKEEQLQRQAEERALREREEAERAQ--------RQKEEEARVREEAERVRQ---EREKH 588
           RE+E + QR+ E    +ERE   + Q        RQ   E R + E ER R+   +R+  
Sbjct: 323 RERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSA 382

Query: 589 FQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
            +REE+ER   + R +E  ++T +     ++T  QR
Sbjct: 383 REREERERDRDRDRQKERERQTEKDRDGQRETEKQR 418



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 49/157 (31%), Positives = 80/157 (50%), Gaps = 8/157 (5%)

Query: 475 DPEEATRLLAEKRRLAREQREKE-ERERREQEELERQKREELAQRVAEERTTRREEESRR 533
           D  E  R    +RR  + Q E+E +R+R  + E +R ++ +  +    +R   RE ++ R
Sbjct: 52  DDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDR 111

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQR--QKEEEARVREEAERVRQ---EREKH 588
            E ++ REKE   Q++ E    RE E     Q   Q+E E +   E ER RQ   ER++ 
Sbjct: 112 -ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170

Query: 589 FQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
            +R  Q+  ER+K  +E  +R R+ E  + KT D+ +
Sbjct: 171 TERNRQKEREREKNRQERRERERQRE-KENKTEDRHS 206



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 40/151 (26%), Positives = 74/151 (49%), Gaps = 1/151 (0%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           D ++  R   ++R   RE+R+ E    R++E    + R     R  E +  R +E  R+ 
Sbjct: 50  DGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQT 109

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
           + E+ R++E++  RQ E     ERE  ER + ++ +  R RE      +ERE+   RE Q
Sbjct: 110 DRERDRQREKERNRQKERERETERE-GERGRDRQTDGQRERERQRDAEKERERQTDRERQ 168

Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
            + ER ++ E   ++ R+     ++  ++ N
Sbjct: 169 RQTERNRQKEREREKNRQERRERERQREKEN 199



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 46/160 (28%), Positives = 81/160 (50%), Gaps = 11/160 (6%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQK---REELAQRVAEERTTRREEES 531
           D +   R    +R+  R+++ + ER+R  + + ERQ+   RE    R  E    R  E  
Sbjct: 269 DRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERE 328

Query: 532 RRLEAEQAREKEEQLQRQAEERALRER------EEAERAQRQKEEEARVREEAERVRQER 585
           R+ E E+ REKE + +R+ +    RER      E   +A+R++E E     ++ R R+ER
Sbjct: 329 RQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREER 388

Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
           E+   R+ Q+  ER+++ E+     R TE   ++  D+ +
Sbjct: 389 ERDRDRDRQK--ERERQTEKDRDGQRETEKQREREKDRES 426



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 40/138 (28%), Positives = 75/138 (54%), Gaps = 5/138 (3%)

Query: 490 AREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQ 549
           A +  + ++RER  Q+E ER++ +   +R  + +  RR E+ R  + ++ RE++   +++
Sbjct: 45  AHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKE 104

Query: 550 AEERALRERE---EAERAQRQKEEEARVREEAERVR-QEREKHFQREEQERLERKKRLEE 605
            E +  RER+   E ER  RQKE E     E ER R ++ +   +RE Q   E+++  + 
Sbjct: 105 RERQTDRERDRQREKER-NRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQT 163

Query: 606 IMKRTRRTEATDKKTSDQ 623
             +R R+TE   +K  ++
Sbjct: 164 DRERQRQTERNRQKERER 181



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 49/164 (29%), Positives = 80/164 (48%), Gaps = 13/164 (7%)

Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR 533
           TD E   +   E+ R    +RE E    R ++     +RE   QR AE+   R+ +  R+
Sbjct: 109 TDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQ 168

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQ---------RQKEEEARVREEAERVRQ- 583
            + E+ R+KE + ++  +ER  RER+  +  +         R++E E     E ER RQ 
Sbjct: 169 RQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQT 228

Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGD 627
           +RE+  QR+ +   ER+K+ E      R TE  DK+   +R+ D
Sbjct: 229 DRERDRQRKTER--EREKQAERERASERETE-RDKERERERDRD 269



 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 49/143 (34%), Positives = 77/143 (53%), Gaps = 13/143 (9%)

Query: 491 REQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQA 550
           RE++   E+ER  Q + ERQ++ E  ++   ER   R+E   R E E+ REKE + + + 
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE---RRERERQREKENKTEDRH 205

Query: 551 EERALRERE-------EAERAQRQKEEEARVRE-EAERVRQ-EREKHFQREEQERLERKK 601
            ER  RERE       E ER ++   E  R R+ E ER +Q ERE+  +RE +   ER++
Sbjct: 206 SERG-RERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERER 264

Query: 602 RLEEIMKRTRRTEATDKKTSDQR 624
             +    R RR +  +++T  +R
Sbjct: 265 ERDRDRDRDRRQKERERQTDRKR 287



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 45/145 (31%), Positives = 75/145 (51%), Gaps = 7/145 (4%)

Query: 486 KRRLAREQREKEERERREQE---ELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
           ++R    +RE+E   +RE E   E ER+++ +    +  ER  +   E RR +AE+ RE+
Sbjct: 315 RKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR-QAERERER 373

Query: 543 EEQLQRQ-AEERALREREEAERAQRQKEEEARVREEAER-VRQEREKHFQREEQERLERK 600
           E +  RQ A ER  RER+     Q+++E +     + +R   ++RE+   RE +   ER 
Sbjct: 374 ERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERG 433

Query: 601 KRLEEIMKRTR-RTEATDKKTSDQR 624
           +  E+   R R R   TD++   QR
Sbjct: 434 REREKQKGRERDRERQTDRQAGRQR 458



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 45/142 (31%), Positives = 77/142 (54%), Gaps = 13/142 (9%)

Query: 485 EKRRLAREQREKE-ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQA--RE 541
           EK R  R +RE++ E+E + ++    + RE   +R  E  T R+ +  R  + ++   RE
Sbjct: 182 EKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERE 241

Query: 542 KEEQLQRQ-AEERAL-----RERE---EAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
           +E+Q +R+ A ER       RERE   + +R +RQKE E +   + +R R ER++  +R+
Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR-RTERDRETERK 300

Query: 593 EQERLERKKRLEEIMKRTRRTE 614
            + + ER++  E   KR R  E
Sbjct: 301 RERQRERERERERNRKRERERE 322



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 37/125 (29%), Positives = 63/125 (50%), Gaps = 3/125 (2%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           +E  R    +  + RE+  +  RE R Q E ER++  E  ++ A ER  R  +  R  + 
Sbjct: 339 KERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQK 398

Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQER 596
           E+ R+ E+    Q E    RERE+   ++R +E   R RE  ++  +ER++  Q + Q  
Sbjct: 399 ERERQTEKDRDGQRETEKQREREKDRESERGRE---RGREREKQKGRERDRERQTDRQAG 455

Query: 597 LERKK 601
            +RK+
Sbjct: 456 RQRKR 460



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 48/182 (26%), Positives = 81/182 (44%), Gaps = 8/182 (4%)

Query: 485 EKRRLAREQREKE-ERERREQEELERQKREELAQ---RVAE-ERTTRREEESRRLEAEQA 539
           E++R     REKE ER+R+ Q E++R++  +  +   R AE ER   RE + +     + 
Sbjct: 328 ERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREE 387

Query: 540 REKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE-REKHFQREEQERLE 598
           RE++    RQ E     E++   + + +K+ E     E+ER R+  RE+  Q+  +   E
Sbjct: 388 RERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRE 447

Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAK--GALTGGTEVSALPCTTNAPGNGKPVG 656
           R+   +   +R R T   +      R+G +       T G    + P    A     P G
Sbjct: 448 RQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWG 507

Query: 657 SP 658
            P
Sbjct: 508 RP 509



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 33/109 (30%), Positives = 56/109 (51%), Gaps = 1/109 (0%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
           D E   +   E RR A  +RE  ERER  Q   ER++RE    R  ++   R+ E+ R  
Sbjct: 352 DRERNRQTGREGRRQAERERE-RERERDRQSAREREERERDRDRDRQKERERQTEKDRDG 410

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ 583
           + E  +++E +  R++E    R RE  ++  R+++ E +   +A R R+
Sbjct: 411 QRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459



 Score = 46.6 bits (109), Expect = 8e-05
 Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 12/109 (11%)

Query: 65  DRQRLARERREEREKQLAAREIVWLERE---------ERARQHYEKHLEERKKRLEEQRQ 115
           DR++  RER+ +R++Q         ER+         ER R    +   ER++  E QR+
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRE 332

Query: 116 KEERRRAAVEEKRRQRLEEDKERHEAV---VRRTMERSQKPKQKHNRWS 161
            E  R    E KR+++ E D+ER+       RR  ER ++ +++ +R S
Sbjct: 333 TERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS 381



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 32/101 (31%), Positives = 52/101 (51%), Gaps = 10/101 (9%)

Query: 62  RVDDRQRLA---RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
           R  +RQR A   RER+ +RE+Q         ER  +  +  EK+ +ER++R E QR+KE 
Sbjct: 147 RERERQRDAEKERERQTDRERQRQT------ERNRQKEREREKNRQERRER-ERQREKEN 199

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           +      E+ R+R  E +   E   +R  +R +  ++K  R
Sbjct: 200 KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTER 240



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 31/98 (31%), Positives = 53/98 (54%), Gaps = 8/98 (8%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           R  DR+R  R+R+ ERE++  A      ERE    +  E+  E  + R  ++RQKE  R+
Sbjct: 226 RQTDRER-DRQRKTEREREKQAERERASERE--TERDKERERERDRDRDRDRRQKERERQ 282

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              + KR++R E D+E      +R  +R ++ +++ NR
Sbjct: 283 T--DRKRQRRTERDRETER---KRERQRERERERERNR 315



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 25/94 (26%), Positives = 49/94 (52%), Gaps = 5/94 (5%)

Query: 64  DDRQRL-ARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
           DDR+R   +ER   REK+   RE    +R+   R+  ++H  +R +  E QR +E+ R  
Sbjct: 52  DDRERNRQKERERRREKRQTERE---TDRKRERRREKDRH-RKRDRHRERQRDREKERER 107

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             + +R ++ E+++ R +   R T    ++ + +
Sbjct: 108 QTDRERDRQREKERNRQKERERETEREGERGRDR 141



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 26/102 (25%), Positives = 52/102 (50%), Gaps = 4/102 (3%)

Query: 62  RVDDRQRLA-RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
           R  DRQR   RER ++ E++ A+      ++E    +  ++  + R+K  E Q  ++ +R
Sbjct: 230 RERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289

Query: 121 RAAVE---EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           R   +   E++R+R  E +   E   +R  ER ++ +++  R
Sbjct: 290 RTERDRETERKRERQRERERERERNRKRERERERERERERQR 331



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 34/157 (21%), Positives = 64/157 (40%), Gaps = 16/157 (10%)

Query: 8   GDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQ 67
           G  H+  DG  R        + + +K  + R       +      ++       + D  +
Sbjct: 43  GQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHR-------KRDRHR 95

Query: 68  RLARERREEREKQLAAREIVWLEREERARQHYEKHLEE-----RKKRLEEQRQKEERRRA 122
              R+R +ERE+Q         E+E   ++  E+  E      R ++ + QR++E +R A
Sbjct: 96  ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              EK R+R + D+ER     R   +  ++ K +  R
Sbjct: 156 ---EKERER-QTDRERQRQTERNRQKEREREKNRQER 188



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 40/165 (24%), Positives = 66/165 (40%), Gaps = 23/165 (13%)

Query: 9   DGHRGGD----GAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVD 64
           +G RG D    G    E   D+ K ++++    R       +       K         +
Sbjct: 134 EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREK---------N 184

Query: 65  DRQRLARERREEREKQLAAREIV-WLERE---------ERARQHYEKHLEERKKRLEEQR 114
            ++R  RER+ E+E +   R      ERE         ER RQ   +   +RK   E ++
Sbjct: 185 RQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREK 244

Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           Q E  R +  E +R +  E +++R     RR  ER ++  +K  R
Sbjct: 245 QAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 25/112 (22%), Positives = 50/112 (44%), Gaps = 3/112 (2%)

Query: 528 EEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREK 587
           +E  RR    QA +  +   R+   +  RER   +R   ++ +  R R   +   ++R++
Sbjct: 34  QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93

Query: 588 HFQREEQERLERKKRLEEIMKRTRRTEATDKKTSD---QRNGDIAKGALTGG 636
           H +R+     ER+++ +    R R  E   +K  +   +R G+  +   T G
Sbjct: 94  HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDG 145



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 25/86 (29%), Positives = 39/86 (45%)

Query: 71  RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
           RER  ERE+Q         ERE + ++  E   E  ++   E R++ ER R    E+ RQ
Sbjct: 321 RERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQ 380

Query: 131 RLEEDKERHEAVVRRTMERSQKPKQK 156
              E +ER     R   +  ++  +K
Sbjct: 381 SAREREERERDRDRDRQKERERQTEK 406



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 13/103 (12%)

Query: 62  RVDDRQR-LARERREEREKQLAAREIVWLERE-----ERARQHYEKHLEERKKRLEEQRQ 115
           R  DRQR   R R++ERE++         +R+     ER RQ   +   ER+   E QRQ
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170

Query: 116 KEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHN 158
            E  R     +K R+R +  +ER E    R  E+  K + +H+
Sbjct: 171 TERNR-----QKEREREKNRQERRER--ERQREKENKTEDRHS 206



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 24/95 (25%), Positives = 48/95 (50%), Gaps = 2/95 (2%)

Query: 65  DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
           +R+R A ER  ER+K+         +R+ R ++  E+  + +++R  E+ ++ ER+R   
Sbjct: 247 ERER-ASERETERDKERERERDRDRDRDRRQKER-ERQTDRKRQRRTERDRETERKRERQ 304

Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            E+ R+R    K   E    R  ER ++ ++   +
Sbjct: 305 RERERERERNRKRERERERERERERQRETERDREK 339



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 1/95 (1%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
           R  +RQR  RER  ER ++         ERE +     ++  E  +KR  +     ER R
Sbjct: 299 RKRERQR-ERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
               E RRQ   E +   E   +   ER ++ + +
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDR 392



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 18/89 (20%), Positives = 40/89 (44%)

Query: 71  RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
           RER  E E +   +     ER+ + +   E+  +  ++R  E+  + ++ R    ++ R 
Sbjct: 212 RERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRD 271

Query: 131 RLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           R    KER     R+   R+++ ++   +
Sbjct: 272 RDRRQKERERQTDRKRQRRTERDRETERK 300



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 26/104 (25%), Positives = 51/104 (49%), Gaps = 7/104 (6%)

Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR-QEREKHFQREE 593
           + E+ R+KE + +R+ + +  RE +     +R+K+   +     ER R +E+E+  Q + 
Sbjct: 53  DRERNRQKERERRRE-KRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDR 111

Query: 594 QERLERKKRLEEIMKRTRRTE-----ATDKKTSDQRNGDIAKGA 632
           +   +R+K      +R R TE       D++T  QR  +  + A
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 42/170 (24%), Positives = 75/170 (44%), Gaps = 11/170 (6%)

Query: 62  RVDDRQR-LARERREEREKQLAAREIVWLER-----EERARQHYEKHLEERKKRLEEQRQ 115
           R  +RQR   R+R +ERE++   +  +  ER      E  RQ   +   ER++  +  R+
Sbjct: 325 RERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARE 384

Query: 116 KEERRRAAVEEKRRQR---LEEDKE-RHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPS 171
           +EER R    +++++R    E+D++ + E   +R  E+ ++ ++   R        G   
Sbjct: 385 REERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRER 444

Query: 172 IHSADPDRRSVSTMNLSK-YVDPVISKRLSSSSATLLNSPDRARRLQLSP 220
                 DR++      S  YV+P      S    +  N P R  R + SP
Sbjct: 445 DRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSP 494



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 10/101 (9%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR---LEEQRQKEE 118
           R  +R+R  R+R  ERE++   RE    ER+    +  EK  E ++KR   ++ +R ++ 
Sbjct: 307 RERERER-NRKRERERERE---RE---RERQRETERDREKERERKRKRQTEMDRERNRQT 359

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            R    + +R +  E +++R  A  R   ER +   ++  R
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRDRQKER 400


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 44/151 (29%), Positives = 90/151 (59%), Gaps = 10/151 (6%)

Query: 483 LAEKRRLAREQREK----EERERREQEELERQKREELAQRVAEERTTRREEESRRL--EA 536
           L E+    REQ EK    E+R R +++EL  Q++E   Q+   E+  + +E+  ++  + 
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323

Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE----REKHFQRE 592
           E+ RE+EE++ RQ E    +E++  E+ Q+ +++E R+ E+ ER+R++    RE+    E
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383

Query: 593 EQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           ++E+++ ++R+ E  K+ R  E T ++  ++
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEK 414



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 44/162 (27%), Positives = 94/162 (58%), Gaps = 17/162 (10%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E+  ++  ++ ++ R++    E+E + +E+ E+ +R+E  +R+ E+    RE+E    E 
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQE--KRLREQEKELREQEKELREQ 302

Query: 537 EQAREKEEQLQRQAE-----ERALREREEAERAQRQK--EEEARVREEAERVRQEREKHF 589
           ++ RE+EEQ+Q Q E     E  +RE+EE    Q ++  E+E ++RE+ +++R + E+ +
Sbjct: 303 KKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 362

Query: 590 Q-----REEQERLERKKRL---EEIMKRTRRTEATDKKTSDQ 623
           +     RE++ER+  ++++   EE M+   R    +KK  ++
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 50/153 (32%), Positives = 82/153 (53%), Gaps = 11/153 (7%)

Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAE 537
           E  + L E+ +  REQ++  E+E + QE+ E+   +E   R  EE+  R+EE  R  E E
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE--RLWEQE 344

Query: 538 QAREKEEQLQRQAEERA------LREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
           +   ++EQ  R  EER       LRE+EE  R Q +  E+    +E ER+R EREK  + 
Sbjct: 345 KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR-EREKKMRE 403

Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
           EE+   E+++++++  +     E  +K+   QR
Sbjct: 404 EEETMREQEEKMQK--QEENMWEQEEKEWQQQR 434



 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 46/153 (30%), Positives = 94/153 (61%), Gaps = 10/153 (6%)

Query: 473 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESR 532
           T D EE  R   E+R   RE++ +EE E   ++E + Q++EE   R  EE+   +EE+ +
Sbjct: 549 TWDQEEKMR--EEERMREREKKMREEEEMMREQEEKMQEQEE-KMREQEEKMWEQEEKMQ 605

Query: 533 RLEAEQAREKEEQLQRQAEERALREREEA--ERAQRQKEEEARVREEAERVRQEREKHFQ 590
             E E+  E+EE++  Q EE  ++E+EE   E+ ++ +E+E ++ E+ E++R++ EK   
Sbjct: 606 EQE-EKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK--M 662

Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           RE++E+++ ++  E++ ++  + +  ++K  +Q
Sbjct: 663 REQEEKMQGQE--EKMREQEEKMQGQEEKMREQ 693



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 49/151 (32%), Positives = 93/151 (61%), Gaps = 15/151 (9%)

Query: 476 PEEATRLLAEKR-RLAREQREKEERERREQEELERQK---REELAQRVAEERTTRREEES 531
           P+  T  L E+  R   E RE+E++ R+++E++ RQ+   RE+  +   +E   RR+E+ 
Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKR 284

Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERV-RQ----- 583
            R + ++ RE+E++L+   E++ LRE+EE  + Q +K  E+E ++RE+ E++ RQ     
Sbjct: 285 LREQEKELREQEKELR---EQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341

Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTE 614
           E+EK  + +EQ+  ++++R+ E  +R R  E
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKE 372



 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 43/166 (25%), Positives = 101/166 (60%), Gaps = 21/166 (12%)

Query: 477 EEATRLLAEKRRLAREQ---REKEERERREQEEL-ERQKREELAQRVAEERTTRREEESR 532
           +E  R+   ++++  E+   RE+EE+ ++++E + E++++E   QR+ E++    E+E  
Sbjct: 389 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 448

Query: 533 RLEAEQAREKEEQLQRQAE----------ERALREREEA--ERAQRQKEEEARVREEAER 580
           + + E+  E+EE+++ Q E          +  +RE+E+   E+ ++ +++E ++ ++ ER
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508

Query: 581 VRQEREKHFQREEQERLERKKRL---EEIMKRTRRTEATDKKTSDQ 623
           + ++ E+   RE++ER+  +K++   EE M+  ++T+  +KKT DQ
Sbjct: 509 MWEQDER--LREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQ 552



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 44/149 (29%), Positives = 95/149 (63%), Gaps = 13/149 (8%)

Query: 485 EKRRLAREQREKEERER-REQEEL---ERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
           E+R   +++R +E+ ER REQ+++   E + REE   +  E++T  +EE+ R  E  + R
Sbjct: 506 EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565

Query: 541 EK----EEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREEQ 594
           EK    EE++ R+ EE+ ++E+EE  R Q +K  E+E +++E+ E++ ++ EK +++EE+
Sbjct: 566 EKKMREEEEMMREQEEK-MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624

Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
           ++++ ++  E + ++  + +  ++K  +Q
Sbjct: 625 DKMQEQE--EMMWEQEEKMQEQEEKMWEQ 651



 Score = 69.7 bits (169), Expect = 9e-12
 Identities = 40/133 (30%), Positives = 78/133 (58%), Gaps = 5/133 (3%)

Query: 478 EATRLLAEKRRLAREQR---EKEERERREQEELERQKRE-ELAQRVAEERTTRREEESRR 533
           E    L EK    REQ+   ++EE+ R E++  E++K+  +  +++ EE   R  E+  R
Sbjct: 511 EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERV-RQEREKHFQRE 592
            E E  RE+EE++Q Q E+   +E +  E+ ++ +E+E ++ E+ E++  QE E   Q +
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630

Query: 593 EQERLERKKRLEE 605
           E+   E++++++E
Sbjct: 631 EEMMWEQEEKMQE 643



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 49/161 (30%), Positives = 92/161 (57%), Gaps = 20/161 (12%)

Query: 483 LAEKRRLAREQREK----EERERREQEELERQKRE--ELAQRVAEERTTRREEESRRLEA 536
           L E+    +EQ EK    EE+ R ++E++ RQ+    E  +++ E+    R++E R  E 
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 364

Query: 537 -EQAREKEEQLQRQA-----EERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
            E+ REKEE+++ Q      EE+   E    ER ++ +EEE  +RE+ E+++++ E  ++
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424

Query: 591 REE----QERL-ERKKRL---EEIMKRTRRTEATDKKTSDQ 623
           +EE    Q+RL E+K++L   E++ ++  +    ++K  DQ
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465



 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 45/151 (29%), Positives = 88/151 (58%), Gaps = 15/151 (9%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQE----ELERQKREELAQRVAEERTTRREEESR 532
           E+  R+  +K+   +E++ +EE++ +EQE    + E + REE   R  E++  R EEE  
Sbjct: 518 EKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKM-REEEEMM 576

Query: 533 RLEAEQAREKEEQLQRQAE-----ERALREREEAERAQRQK----EEEARVREEAERVRQ 583
           R + E+ +E+EE+++ Q E     E  ++E+EE    Q +K    EEE +++E+ E + +
Sbjct: 577 REQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWE 636

Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTE 614
           + EK  Q +E++  E+++++ E  ++ R  E
Sbjct: 637 QEEK-MQEQEEKMWEQEEKMREQEEKMREQE 666



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 45/140 (32%), Positives = 80/140 (57%), Gaps = 16/140 (11%)

Query: 478 EATRLLAEKRRLAREQREK---EERERREQEELERQKREELAQRVA-----EERTTRREE 529
           E  + + E+  + REQ EK   +E + REQEE   ++ E++ ++       EE+   +EE
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623

Query: 530 ESRRLEAEQAR-EKEEQLQRQAE-----ERALREREEAERAQRQK--EEEARVREEAERV 581
           E +  E E+   E+EE++Q Q E     E  +RE+EE  R Q +K   +E ++RE+ E++
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683

Query: 582 RQEREKHFQREEQERLERKK 601
           + + EK  ++EE+ R + +K
Sbjct: 684 QGQEEKMREQEEKMRGQEEK 703



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 40/154 (25%), Positives = 86/154 (55%), Gaps = 11/154 (7%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAE-ERTTRREEESRRLE 535
           ++  R+  +  RL    REKEER R +++  E++++ +  +R+ E E+  R EEE+ R +
Sbjct: 356 DQEERMWEQDERL----REKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411

Query: 536 AEQAREKEEQLQRQAE-----ERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
            E+ +++EE +  Q E     +R   ++E+    ++ +E+E ++ E+ E++R + E   Q
Sbjct: 412 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 471

Query: 591 REEQERLERKKRLEEIM-KRTRRTEATDKKTSDQ 623
            ++  R E+ +  E+ M ++  +    ++K  DQ
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 505



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 41/131 (31%), Positives = 82/131 (62%), Gaps = 10/131 (7%)

Query: 497 EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALR 556
           +E   R++EEL  Q+++   Q   EE+  R+EE  R  E +  RE+EE+++RQ  E+ LR
Sbjct: 233 QEEMWRQEEELREQEKKIRKQ---EEKMWRQEERLREQEGKM-REQEEKMRRQ--EKRLR 286

Query: 557 EREEAERAQ-RQKEEEARVREEAERVRQEREKHFQREEQERLERKK---RLEEIMKRTRR 612
           E+E+  R Q ++  E+ ++RE+ E+++++ EK +++EE+ R + +K   + E + ++ ++
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346

Query: 613 TEATDKKTSDQ 623
               ++K  DQ
Sbjct: 347 MREQEQKMRDQ 357



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 36/143 (25%), Positives = 86/143 (60%), Gaps = 7/143 (4%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E+  ++  ++ ++  ++++  ++E R  E+ ER + +E  +R+ E++   ++EE  R E 
Sbjct: 483 EQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE--ERMREQKKMWQQEEKMREEK 540

Query: 537 ---EQAREKEEQLQRQAEERALREREEAERAQRQ--KEEEARVREEAERVRQEREKHFQR 591
              EQ ++  +Q ++  EE  +RERE+  R + +  +E+E +++E+ E++R++ EK +++
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600

Query: 592 EEQERLERKKRLEEIMKRTRRTE 614
           EE+ + + +K  E+  K   + E
Sbjct: 601 EEKMQEQEEKMWEQEEKMWEQEE 623



 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 44/202 (21%), Positives = 96/202 (47%), Gaps = 2/202 (0%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E+  ++  ++ ++  ++ +  E+E +  E+ E  K +E  + + E+    +E+E +  E 
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ 651

Query: 537 EQA-REKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHF-QREEQ 594
           E+  RE+EE+++ Q E+   +E +  E+ ++ + +E ++RE+ E++R + EK + Q E+ 
Sbjct: 652 EEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM 711

Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKP 654
              E K   +E M+         K+   +R  +  +         S + C  +  G+ +P
Sbjct: 712 WGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSVEP 771

Query: 655 VGSPHVVTSHQSKVTVESTPDL 676
            G      S Q   T +    L
Sbjct: 772 AGGEAGEGSPQDNPTAQEIMQL 793



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 35/133 (26%), Positives = 75/133 (56%), Gaps = 5/133 (3%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE---ESRRLEAEQARE 541
           EK R   +Q  ++E + R+QE+    + E + ++  +ER   +EE   E +++  ++ + 
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ--DERLREKEERMREQKKMWQQEEKM 536

Query: 542 KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKK 601
           +EE+  ++ E++   + E+    +R +E E ++REE E +R++ EK  ++EE+ R + +K
Sbjct: 537 REEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEK 596

Query: 602 RLEEIMKRTRRTE 614
             E+  K   + E
Sbjct: 597 MWEQEEKMQEQEE 609



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 39/130 (30%), Positives = 78/130 (60%), Gaps = 7/130 (5%)

Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
           EK+   +E+  ++E +  EQEE  R + +++  +  EER   ++E   RL  ++ R +E+
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ--EERMWEQDE---RLREKEERMREQ 526

Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLE 604
           +   Q EE+   E++  E+ ++  ++E ++REE ER+R EREK  + EE+   E++++++
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE-ERMR-EREKKMREEEEMMREQEEKMQ 584

Query: 605 EIMKRTRRTE 614
           E  ++ R  E
Sbjct: 585 EQEEKMREQE 594



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 45/147 (30%), Positives = 83/147 (56%), Gaps = 16/147 (10%)

Query: 483 LAEKRRLAREQREKEERERRE-QEELERQK--REELAQRVAEERTTRREEESRRLEAEQA 539
           L EK RLA  ++ + +   +E + +LER K    ++     +E   R+EEE R  E ++ 
Sbjct: 192 LQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE-KKI 250

Query: 540 REKEEQLQRQAE-----ERALREREEAERAQ--RQKEEEARVREEAERVRQ-----EREK 587
           R++EE++ RQ E     E  +RE+EE  R Q  R +E+E  +RE+ + +R+     E+E+
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEE 310

Query: 588 HFQREEQERLERKKRLEEIMKRTRRTE 614
             Q +E++  E+++++ E  ++  R E
Sbjct: 311 QMQEQEEKMWEQEEKMREQEEKMWRQE 337



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 41/144 (28%), Positives = 80/144 (55%), Gaps = 6/144 (4%)

Query: 481 RLLAEKRRLAREQREKEERERR-EQEELERQKREELAQRVAEERTTRREEESRRLEAEQA 539
           RL  +K +L  +++ +E+ E+  EQEE  R + E   Q    E+   R+E+ R  E +Q 
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ----EKKMWRQEKMREQE-DQM 488

Query: 540 REKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
            E+EE+++ Q ++   +E    E+ +R +E+E R+RE+ +  +QE +   +++ QE+ ++
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKK 548

Query: 600 KKRLEEIMKRTRRTEATDKKTSDQ 623
               EE M+   R    +KK  ++
Sbjct: 549 TWDQEEKMREEERMREREKKMREE 572



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 43/150 (28%), Positives = 76/150 (50%), Gaps = 14/150 (9%)

Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR 533
           T   +A  L   +  +  E+ +K+  E +E+  L   ++ E+   V E +  + E     
Sbjct: 165 TKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKR-KLERAKFL 223

Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQK---------EEEARVREEAERVRQE 584
           L   Q    +E++ RQ EE  LRE+E+  R Q +K         E+E ++RE+ E++R++
Sbjct: 224 LPQVQTNTLQEEMWRQEEE--LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQ 281

Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTE 614
            EK  + +E+E  E++K L E  K+ R  E
Sbjct: 282 -EKRLREQEKELREQEKELRE-QKKLREQE 309



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 41/141 (29%), Positives = 76/141 (53%), Gaps = 31/141 (21%)

Query: 475 DPEEATRLLAEKRRLAREQREKEERERR--EQEELERQKREELAQRVAEERTTRREEESR 532
           + EE  ++  ++  +  ++ + +E+E +  EQEE  R++ E++          R +EE  
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM----------REQEEKM 669

Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQK----EE-----------EARVREE 577
           + + E+ RE+EE++Q Q E+  +RE+EE  R Q +K    EE           +  +RE+
Sbjct: 670 QGQEEKMREQEEKMQGQEEK--MREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREK 727

Query: 578 AERVRQEREKHFQR--EEQER 596
            ER+R ++EK  +R  E +ER
Sbjct: 728 EERIRDQKEKMQERLPEHEER 748



 Score = 47.4 bits (111), Expect = 5e-05
 Identities = 29/88 (32%), Positives = 51/88 (57%), Gaps = 3/88 (3%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEKHLEERKK--RLEEQRQKEERRRAAVEEKRR 129
           ER  EREK++   E +  E+EE+ ++  EK  E+ +K    EE+ Q++E +    EEK  
Sbjct: 560 ERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619

Query: 130 QRLEEDK-ERHEAVVRRTMERSQKPKQK 156
           ++ EEDK +  E ++    E+ Q+ ++K
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEK 647



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 8/105 (7%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           D+R R   ER  E+EK     E +  E   R R+   +  EE  +  EE+ QK+E     
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424

Query: 124 VEEK--RRQRLEEDK------ERHEAVVRRTMERSQKPKQKHNRW 160
            EEK  ++QRL E K      E+ +    +  E+ +K + +   W
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 469



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 31/92 (33%), Positives = 50/92 (54%), Gaps = 9/92 (9%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQR---QKEERRRAAVEEKR 128
           ER  E+EKQ+  +E    ++EER  +  E+ L E+++R+ EQ    ++EE+    ++E+ 
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDER-LREKEERMREQEKMWEQEEK----MQEEE 392

Query: 129 RQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
           R R  E K R E    R  E   + KQ+ N W
Sbjct: 393 RIREREKKMREEEETMREQEEKMQ-KQEENMW 423



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 24/90 (26%), Positives = 48/90 (53%), Gaps = 5/90 (5%)

Query: 72  ERREEREKQLAAREIVWLE----REERARQHYEKHL-EERKKRLEEQRQKEERRRAAVEE 126
           ER  E+E+++  ++ +W +    REE+  Q  EK   ++ +K  EE+R +E  ++   EE
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573

Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           +  +  EE  +  E  +R   E+  + ++K
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEK 603



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 25/91 (27%), Positives = 49/91 (53%), Gaps = 6/91 (6%)

Query: 74  REEREKQLAAREIVWLEREERARQHYEKHLE-ERKKRLEEQRQKEERRRAAVEEKRRQRL 132
           +EE +K     E++W E+EE+ ++  EK  E E K R +E++ +E+  +   +E++ +  
Sbjct: 621 QEEEDKMQEQEEMMW-EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679

Query: 133 EEDKERHEAVVRRTMERSQKPKQKHNRWSWG 163
           EE  +  E  +R   E+ +  ++K     WG
Sbjct: 680 EEKMQGQEEKMREQEEKMRGQEEK----MWG 706



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 22/99 (22%), Positives = 49/99 (49%), Gaps = 3/99 (3%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           ++  R   E RE+ +K     E +W + E    Q  +   +E K R +E+R +E+ +   
Sbjct: 234 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELR 293

Query: 124 VEEK---RRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            +EK    +++L E +E+ +    +  E+ +K +++  +
Sbjct: 294 EQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 26/93 (27%), Positives = 49/93 (52%), Gaps = 2/93 (2%)

Query: 68  RLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEK 127
           R   E+   +E++L  +E    E+EE+ R+  EK L E++K L EQ +KE R +  + E+
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRRQ-EKRLREQEKELREQ-EKELREQKKLREQ 308

Query: 128 RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
             Q  E++++  E   +   +  +  +Q+   W
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 23/96 (23%), Positives = 51/96 (53%), Gaps = 3/96 (3%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKK---RLEEQRQKEERR 120
           ++  R   E+ +E+E+++  +E    E+EE+ ++  EK  E+ +K   + EE + +E+  
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE 632

Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
               +E++ Q  EE     E  +R   E+ ++ ++K
Sbjct: 633 MMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK 668



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 25/97 (25%), Positives = 47/97 (48%), Gaps = 12/97 (12%)

Query: 74  REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE-------- 125
           R++ +K     E +W E++ER R+  E+  E++K   +E++ +EE++    E        
Sbjct: 496 RDQEQKMWDQEERMW-EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEE 554

Query: 126 ---EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              E+ R R  E K R E  + R  E   + +++  R
Sbjct: 555 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMR 591



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 37/145 (25%), Positives = 75/145 (51%), Gaps = 10/145 (6%)

Query: 470 SAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
           SA +T  ++A R + E  +       +  R     EEL++ K  EL +++    + + E 
Sbjct: 148 SAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKK-KNAELQEKLRLAESEKSEI 206

Query: 530 ESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHF 589
           +    E ++  E+ + L  Q +   L+E        RQ+EE   +RE+ +++R++ EK +
Sbjct: 207 QLNVKELKRKLERAKFLLPQVQTNTLQEE-----MWRQEEE---LREQEKKIRKQEEKMW 258

Query: 590 QREEQERLERKKRLEEIMKRTRRTE 614
           ++EE+ R E++ ++ E  ++ RR E
Sbjct: 259 RQEERLR-EQEGKMREQEEKMRRQE 282



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 26/98 (26%), Positives = 54/98 (55%), Gaps = 3/98 (3%)

Query: 60  VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQR--QKE 117
           + + +++     ER  E+E ++  +E     +E+R R+  EK L E++K L EQ+  +++
Sbjct: 250 IRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ-EKELREQEKELREQKKLREQ 308

Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
           E +    EEK  ++ E+ +E+ E + R+     ++ KQ
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 28/102 (27%), Positives = 55/102 (53%), Gaps = 4/102 (3%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR-LEEQRQKEERR 120
           R ++R R    +  E+E+++  +E    E+E+  R+  ++  E++K R  EEQ Q++E +
Sbjct: 259 RQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK 318

Query: 121 RAAVEEKRRQRLEE---DKERHEAVVRRTMERSQKPKQKHNR 159
               EEK R++ E+    +ER     ++  E+ QK + +  R
Sbjct: 319 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 360



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 24/100 (24%), Positives = 49/100 (49%), Gaps = 6/100 (6%)

Query: 67  QRLARERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERRRAAV 124
           +RL  + +E RE++   RE   L  +E   Q  E+ +  +E K R +E++   +  R   
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 342

Query: 125 EEK----RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
           +EK    + Q++ + +ER      R  E+ ++ +++   W
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 26/98 (26%), Positives = 45/98 (45%), Gaps = 5/98 (5%)

Query: 64  DDRQRLARERREEREKQLAAREIV-----WLEREERARQHYEKHLEERKKRLEEQRQKEE 118
           D+R R   ER  E++K     E +       E+E++     EK  EE + R  E++ +EE
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
                 +E++ Q  EE     E  +    E+ Q+ ++K
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK 610



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 24/99 (24%), Positives = 54/99 (54%), Gaps = 7/99 (7%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERAR------QHYEKHLEERKKRLEEQRQKE 117
           +++ R   ++  ++E+++  ++    E+EER R      Q  EK  EE+K + +E++  +
Sbjct: 492 EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWD 551

Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
           +  +   EE+ R+R E+     E ++R   E+ Q+ ++K
Sbjct: 552 QEEKMREEERMRER-EKKMREEEEMMREQEEKMQEQEEK 589



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 21/101 (20%), Positives = 54/101 (53%), Gaps = 3/101 (2%)

Query: 62  RVDDRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
           R+ +R++  RE  E   E+E+++  +E    E+EE+  +  EK  E+ +K  E++ +  E
Sbjct: 561 RMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE 620

Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           +      +++ + + E +E+ +    +  E+ +K +++  +
Sbjct: 621 QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK 661



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 27/97 (27%), Positives = 53/97 (54%), Gaps = 7/97 (7%)

Query: 66  RQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
           RQ   RE+ +   E+E+++  +E    ++EER  +  E+ L E+++R+ EQ++  ++   
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDER-LREKEERMREQKKMWQQEEK 535

Query: 123 AVEEKRRQRLEE---DKERHEAVVRRTMERSQKPKQK 156
             EEK+ Q  E+   D+E       R  ER +K +++
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 22/79 (27%), Positives = 45/79 (56%), Gaps = 2/79 (2%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRR 121
           +D+ +   E   E+E+++  +E    E+EE+ R+  EK    EE+ +  EE+ +++E + 
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683

Query: 122 AAVEEKRRQRLEEDKERHE 140
              EEK R++ E+ + + E
Sbjct: 684 QGQEEKMREQEEKMRGQEE 702



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 27/84 (32%), Positives = 45/84 (53%), Gaps = 10/84 (11%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHL---------EERKKRLEEQR 114
           +++ +   E+  E+E+++  +E    E+EE+ R   EK           EE+    EE R
Sbjct: 666 EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMR 725

Query: 115 QKEERRRAAVEEKRRQRLEEDKER 138
           +KEER R   +EK ++RL E +ER
Sbjct: 726 EKEERIRDQ-KEKMQERLPEHEER 748



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 25/116 (21%), Positives = 60/116 (51%), Gaps = 9/116 (7%)

Query: 55  PDPPPVLRVDDRQRLARERREEREKQLAAREIVW-----LEREERARQHYEKHLEERKKR 109
           P+    L   ++ +   E+  E+E+++  +E +W     + R+E+ R+  E  + E++++
Sbjct: 436 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ-EDQMWEQEEK 494

Query: 110 LEEQRQK---EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
           + +Q QK   +E R    +E+ R++ E  +E+ +   +    R +K  Q+  + +W
Sbjct: 495 MRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTW 550



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 19/93 (20%), Positives = 45/93 (48%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
           + ++   +E +   EK+   +E    ++EE+ R+       E+K R EE+  +E+  +  
Sbjct: 525 EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 584

Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            +E++ +  EE     E  ++   E+  + ++K
Sbjct: 585 EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617



 Score = 36.6 bits (83), Expect = 0.088
 Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 14/99 (14%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRRAAVEEKRR 129
           E+ +E+E+++  +E    E+EE+ R+  EK    EE+ +  EE+ Q +E +    EEK R
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698

Query: 130 QRLE------------EDKERHEAVVRRTMERSQKPKQK 156
            + E            E+K   +  +R   ER +  K+K
Sbjct: 699 GQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEK 737



 Score = 36.2 bits (82), Expect = 0.11
 Identities = 24/95 (25%), Positives = 50/95 (52%), Gaps = 2/95 (2%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE-ERKKRLEEQRQKEERRRA 122
           +++ R   E+  E+E+++  +E    E+EE+ +   EK  E E K R +E++   +  + 
Sbjct: 652 EEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM 711

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKH 157
             +E++    EE +E+ E  +R   E+ Q+   +H
Sbjct: 712 WGQEEKMWGQEEMREKEER-IRDQKEKMQERLPEH 745



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 20/105 (19%)

Query: 72  ERREEREKQL-------AAREIVWLEREERARQ------------HYEKHLEERKKRLEE 112
           +R+ ER K L         +E +W + EE   Q              E+ L E++ ++ E
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273

Query: 113 QRQKEERRRAAVEEKRRQRLEEDKE-RHEAVVRRTMERSQKPKQK 156
           Q +K  R+   + E+ ++  E++KE R +  +R   E+ Q+ ++K
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK 318



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 18/97 (18%), Positives = 49/97 (50%), Gaps = 2/97 (2%)

Query: 64  DDRQRLARERR-EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
           +++ R   E+  E+ EK     E +W + E+   Q  E  ++E+++ + EQ +K + +  
Sbjct: 587 EEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEE 646

Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            + E+  +++ E +E+      +   + +K +++  +
Sbjct: 647 KMWEQE-EKMREQEEKMREQEEKMQGQEEKMREQEEK 682



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 22/90 (24%), Positives = 45/90 (50%), Gaps = 6/90 (6%)

Query: 71  RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
           +E +   E+++  RE    E EE  R+      EE+ +  EE+ +++E +    EEK ++
Sbjct: 552 QEEKMREEERMREREKKMREEEEMMREQ-----EEKMQEQEEKMREQEEKMWEQEEKMQE 606

Query: 131 RLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
           + E+  E+ E +  +  E  +  +Q+   W
Sbjct: 607 QEEKMWEQEEKMWEQE-EEDKMQEQEEMMW 635


>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 523

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 58/177 (32%), Positives = 87/177 (49%), Gaps = 7/177 (3%)

Query: 444 APAPVPTPAMVSAPSSTVNASASVKTSAGT---TDPEEATRLLAEKRRLAREQREKEERE 500
           AP P   P+ V       N       S G     + E    L    RR     RE+EER 
Sbjct: 149 APEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERL 208

Query: 501 RREQEELERQKRE--ELAQRVAEERTTRREEESRRLEAEQ-AREKEEQLQRQAEERALRE 557
           R ++E L  Q+    E  +R+ E+    RE+E R  E E+  RE EE+L  Q E    +E
Sbjct: 209 REQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQE 268

Query: 558 REEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
               E+ +R  E+E R+ E+ ER+R++ E+  ++EE+ R E+++RL E  +R R  E
Sbjct: 269 ERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLR-EQEERLCEQEERLREQE 324



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 49/164 (29%), Positives = 90/164 (54%), Gaps = 18/164 (10%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
           E+  RL  ++ RL  ++    E+E R +E+ ER + +E  +R+ E+    RE E R  E 
Sbjct: 203 EQEERLREQEERLREQEERLCEQEERLREQEERLREQE--ERLCEQEERLREHEERLCEQ 260

Query: 537 EQAR-EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE--- 592
           E+   E+EE+L+ Q E    +E    E+ +R +E+E R+ E+ ER+R++ E+  ++E   
Sbjct: 261 EERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERL 320

Query: 593 --------EQERLERKKRL----EEIMKRTRRTEATDKKTSDQR 624
                   EQE+L  ++RL    E+++++ RR E  ++    +R
Sbjct: 321 REQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERER 364



 Score = 70.5 bits (171), Expect = 5e-12
 Identities = 54/172 (31%), Positives = 87/172 (50%), Gaps = 24/172 (13%)

Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE- 535
           E   RL  ++ RL  ++    E+E R  E+ ER   +E   R  EER   +EE  R  E 
Sbjct: 252 EHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEE 311

Query: 536 -----AEQAREKEEQLQRQ----AEERALREREEAERAQRQKEEEARVRE---------- 576
                 E+ RE+EE+L  Q     +ER L E E+    +R++EE+ R+ E          
Sbjct: 312 RLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEE 371

Query: 577 --EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNG 626
             E ER+RQ+ E+ +Q+E  + LER + LE +++     EA  ++ ++ R+G
Sbjct: 372 LLEQERLRQQDERLWQQETLQELERLRELERMLE--LGWEALYEQRAEPRSG 421



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 56/155 (36%), Positives = 84/155 (54%), Gaps = 27/155 (17%)

Query: 477 EEATRLLAEKRRLAREQREKEERERR--EQEELERQKREELAQ---RVAEERTTRREEES 531
           E+  RL  ++ RL  ++    E+E R  EQEE  R+  E L +   R+ E+    RE+E 
Sbjct: 217 EQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEE 276

Query: 532 RRLEAEQA--------REKEEQLQRQAEERALREREE--AERAQRQKEEEARVREEAERV 581
           R  E E+         RE+EE+L  Q  E  LRE+EE   E+ +R +E+E R+ E+ +  
Sbjct: 277 RLHEQEERLCEQEERLREQEERLCEQ--EERLREQEERLCEQEERLREQEERLCEQEKLP 334

Query: 582 RQER---------EKHFQREEQER-LERKKRLEEI 606
            QER         E+  ++EEQER LER++ LEE+
Sbjct: 335 GQERLLEEVEKLLEQERRQEEQERLLERERLLEEV 369



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 33/104 (31%), Positives = 58/104 (55%), Gaps = 7/104 (6%)

Query: 62  RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL--EEQRQKEER 119
           R ++R R   ER  E+E++L  +E    E+EER R+  E+ L E+++RL  +E+R +E  
Sbjct: 196 RQEERLREQEERLREQEERLREQEERLCEQEERLREQ-EERLREQEERLCEQEERLREHE 254

Query: 120 RRAAVEEKR----RQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            R   +E+R     +RL E +ER      R  E+ ++ +++  R
Sbjct: 255 ERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEER 298



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 28/89 (31%), Positives = 50/89 (56%), Gaps = 4/89 (4%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLE-EQRQKEERRRAAVEEKRRQ 130
           ER  E+E++L  +E    E+EER R+H E+  E+ ++  E E+R +E+  R   +E   +
Sbjct: 227 ERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQE---E 283

Query: 131 RLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           RL E +ER      R  E+ ++ +++  R
Sbjct: 284 RLCEQEERLREQEERLCEQEERLREQEER 312



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 31/100 (31%), Positives = 54/100 (54%), Gaps = 10/100 (10%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK----EER 119
           ++R R   ER  E+E++L   E    E+EER  +  E+ L E+++RL EQ ++    EER
Sbjct: 233 EERLREQEERLCEQEERLREHEERLCEQEERLCEQ-EERLREQEERLHEQEERLCEQEER 291

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
            R     ++ +RL E +ER      R  E+ ++ +++  R
Sbjct: 292 LR-----EQEERLCEQEERLREQEERLCEQEERLREQEER 326



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 31/98 (31%), Positives = 55/98 (56%), Gaps = 11/98 (11%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL--EEQRQKEERRR 121
           ++R R   ER  E+E++L  +E    E+EER  +  E+ L E+++RL  +E+R +E+  R
Sbjct: 268 EERLREQEERLHEQEERLCEQEERLREQEERLCEQ-EERLREQEERLCEQEERLREQEER 326

Query: 122 AAVEEK---RRQRLEE-----DKERHEAVVRRTMERSQ 151
              +EK   + + LEE     ++ER +    R +ER +
Sbjct: 327 LCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERER 364



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 23/125 (18%)

Query: 481 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
           RLL E  +L  ++R +EE+ER  + E   ++ EEL                  LE E+ R
Sbjct: 338 RLLEEVEKLLEQERRQEEQERLLERERLLEEVEEL------------------LEQERLR 379

Query: 541 EKEEQLQRQAEERALREREEAERA-----QRQKEEEARVREEAERVRQEREKHFQREEQE 595
           +++E+L +Q   + L    E ER      +   E+ A  R   E +  E +   Q E+Q 
Sbjct: 380 QQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQV 439

Query: 596 RLERK 600
           +  +K
Sbjct: 440 KELKK 444



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 32/97 (32%), Positives = 53/97 (54%), Gaps = 10/97 (10%)

Query: 64  DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK----EER 119
           ++R R   ER  E+E++L  +E    E+EER  +  E+ L E+++RL EQ ++    EER
Sbjct: 247 EERLREHEERLCEQEERLCEQEERLREQEERLHEQ-EERLCEQEERLREQEERLCEQEER 305

Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
            R     ++ +RL E +ER      R  E+ + P Q+
Sbjct: 306 LR-----EQEERLCEQEERLREQEERLCEQEKLPGQE 337



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 28/98 (28%), Positives = 53/98 (54%), Gaps = 5/98 (5%)

Query: 63  VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKK-RLEEQRQKEERRR 121
           V++ Q L+   R + E+ L  +E    E+EER R+  E+  E+ ++ R +E+R +E+  R
Sbjct: 184 VENNQMLSLLNRRQEER-LREQEERLREQEERLREQEERLCEQEERLREQEERLREQEER 242

Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
              +E   +RL E +ER      R  E+ ++ +++  R
Sbjct: 243 LCEQE---ERLREHEERLCEQEERLCEQEERLREQEER 277



 Score = 38.9 bits (89), Expect = 0.018
 Identities = 28/89 (31%), Positives = 49/89 (55%), Gaps = 5/89 (5%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK----EERRRAAVEEK 127
           ER  E+E++L  +E    E+EER R+  E+ L E+++RL EQ ++    EER R   E  
Sbjct: 269 ERLREQEERLHEQEERLCEQEERLREQ-EERLCEQEERLREQEERLCEQEERLREQEERL 327

Query: 128 RRQRLEEDKERHEAVVRRTMERSQKPKQK 156
             Q     +ER    V + +E+ ++ +++
Sbjct: 328 CEQEKLPGQERLLEEVEKLLEQERRQEEQ 356



 Score = 37.0 bits (84), Expect = 0.067
 Identities = 29/98 (29%), Positives = 51/98 (52%), Gaps = 10/98 (10%)

Query: 72  ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR------AAVE 125
           ER  E+E++L  +E    E+EER  +  E+ L E+++RL EQ +   + R        +E
Sbjct: 290 ERLREQEERLCEQEERLREQEERLCEQ-EERLREQEERLCEQEKLPGQERLLEEVEKLLE 348

Query: 126 EKRRQRLEE---DKERHEAVVRRTMERSQKPKQKHNRW 160
           ++RRQ  +E   ++ER    V   +E+ +  +Q    W
Sbjct: 349 QERRQEEQERLLERERLLEEVEELLEQERLRQQDERLW 386



 Score = 34.7 bits (78), Expect = 0.33
 Identities = 38/122 (31%), Positives = 52/122 (42%), Gaps = 17/122 (13%)

Query: 477 EEATRLLAEKRR-------LAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
           EE  +LL ++RR       L RE+  +E  E  EQE L RQ+ E L Q+   +   R  E
Sbjct: 341 EEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERL-RQQDERLWQQETLQELERLRE 399

Query: 530 ESRRLEA------EQAREKE---EQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
             R LE       EQ  E     E+L  + +     E++  E  +    EE R  E A  
Sbjct: 400 LERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEPRGSESAAA 459

Query: 581 VR 582
            R
Sbjct: 460 AR 461



 Score = 34.3 bits (77), Expect = 0.43
 Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 20/116 (17%)

Query: 55  PDPPP----VLRVDDRQRLARERREEREKQLAAR-------EIVWLEREERARQHYEKHL 103
           P+PP     V ++ D     R+  E   +QL A         ++   +EER R+      
Sbjct: 150 PEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQ----- 204

Query: 104 EERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
           EER +  EE+ +++E R    EE+ R++ E  +E+ E    R  E+ ++ ++   R
Sbjct: 205 EERLREQEERLREQEERLCEQEERLREQEERLREQEE----RLCEQEERLREHEER 256


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.307    0.124    0.341 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,540,581
Number of Sequences: 37866
Number of extensions: 2066862
Number of successful extensions: 98782
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1549
Number of HSP's successfully gapped in prelim test: 2416
Number of HSP's that attempted gapping in prelim test: 20086
Number of HSP's gapped (non-prelim): 34727
length of query: 749
length of database: 18,247,518
effective HSP length: 110
effective length of query: 639
effective length of database: 14,082,258
effective search space: 8998562862
effective search space used: 8998562862
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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