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Search of human proteins with 4505101
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4505101 microtubule-associated protein 7 [Homo sapiens]
(749 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 1471 0.0
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 391 e-108
gi|22758136 MAP7 domain containing 2 [Homo sapiens] 279 8e-75
gi|147903302 MAP7 domain containing 3 [Homo sapiens] 155 1e-37
gi|148746195 trichohyalin [Homo sapiens] 90 7e-18
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 89 1e-17
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 89 1e-17
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 89 1e-17
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 89 1e-17
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 88 3e-17
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 84 6e-16
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 82 1e-15
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 81 3e-15
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 81 4e-15
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 80 5e-15
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 80 7e-15
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 80 9e-15
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 79 1e-14
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 79 2e-14
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 79 2e-14
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 78 3e-14
gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapi... 77 4e-14
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 77 4e-14
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 77 6e-14
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 77 6e-14
gi|7661936 scaffold attachment factor B2 [Homo sapiens] 77 6e-14
gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo ... 77 8e-14
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 76 1e-13
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 76 1e-13
gi|239745299 PREDICTED: hypothetical protein [Homo sapiens] 76 1e-13
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 1471 bits (3809), Expect = 0.0
Identities = 749/749 (100%), Positives = 749/749 (100%)
Query: 1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV 60
MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV
Sbjct: 1 MAELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPV 60
Query: 61 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR
Sbjct: 61 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR
Sbjct: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
Query: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 240
SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS
Sbjct: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 240
Query: 241 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER 300
KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER
Sbjct: 241 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERER 300
Query: 301 ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ 360
ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ
Sbjct: 301 ENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQ 360
Query: 361 VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP 420
VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP
Sbjct: 361 VRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEP 420
Query: 421 EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT 480
EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT
Sbjct: 421 EVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEAT 480
Query: 481 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR
Sbjct: 481 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
Query: 541 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK
Sbjct: 541 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
Query: 601 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV 660
KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV
Sbjct: 601 KRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHV 660
Query: 661 VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN 720
VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN
Sbjct: 661 VTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTNSESPEIPLN 720
Query: 721 PILAFDDEGTLGPLPQVDGVQTQQTAEVI 749
PILAFDDEGTLGPLPQVDGVQTQQTAEVI
Sbjct: 721 PILAFDDEGTLGPLPQVDGVQTQQTAEVI 749
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 391 bits (1005), Expect = e-108
Identities = 269/648 (41%), Positives = 353/648 (54%), Gaps = 95/648 (14%)
Query: 51 SGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL 110
S + P V + +R +LA+ERREER K LAA++ VWLE+EE+A+ EK L+ER++RL
Sbjct: 123 SDSPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRL 182
Query: 111 EEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSP 170
EEQR K E+RRAA+EE++RQ+LE++KER+EA ++R+++++ + + RWSW G+LH S
Sbjct: 183 EEQRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWA-EIRQQRWSWAGALHHSS 241
Query: 171 SIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLL 230
H R SVS +NL K+VD +I+KRLS SSATL NSP R R LQLS WESS+V+RL+
Sbjct: 242 PGHKTSGSRCSVSAVNLPKHVDSIINKRLSKSSATLWNSPSRNRSLQLSAWESSIVDRLM 301
Query: 231 TPTHSFLARSKSTAAL-------------------------------------------S 247
TPT SFLARS+S L
Sbjct: 302 TPTLSFLARSRSAVTLPRNGRDQGRGCDPGRGPTWGRAGASLARGPQPDRTHPSAAVPVC 361
Query: 248 GEAASCSPI--------IMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERE 299
+AS SP+ + A R +P +P R KK++E
Sbjct: 362 PRSASASPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKE 421
Query: 300 REN------VLFLTSGTRRAVSPSNPKARQPA--RSRLWLPSKSLPHLPGTP--RPTSSL 349
REN + S +R P++P+AR A S L SK+ P P T RP S
Sbjct: 422 RENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWHRPASPC 481
Query: 350 P-PGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVE 408
P PG P PP P + R K +K+ KE PS G + +
Sbjct: 482 PSPG-----PGHTLPPKPPSPRGTTASPKGRVRRKEEAKE------SPSAAGPEDKSQSK 530
Query: 409 EATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTP---AMVSAPSSTVNASA 465
E+ A PA+PA +PAP+ PAP P P TP A++++P +
Sbjct: 531 RRASNEKESA----APASPAPSPAPSPTPAPPQKEQP-PAETPTDAAVLTSPPAPAPPVT 585
Query: 466 SVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTT 525
K AGTTD EEATRLLAEKRR AREQRE+EE+ERR Q E +++ REE R AE R
Sbjct: 586 PSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEAR-A 644
Query: 526 RREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE-EARVREEAERVRQE 584
RE E+RR E ++AREK A E+EE ER Q+QKEE EAR REEAER R E
Sbjct: 645 EREAEARRREEQEAREK-----------AQAEQEEQERLQKQKEEAEARSREEAERQRLE 693
Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGA 632
REKHFQ++EQER ER+KRLEEIMKRTR++E ++ K A G+
Sbjct: 694 REKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGS 741
Score = 67.0 bits (162), Expect = 6e-11
Identities = 64/237 (27%), Positives = 105/237 (44%), Gaps = 30/237 (12%)
Query: 350 PPGSVKAAPAQVRPPSPGNIRP----VKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLV 405
PP V P + RP G+ P + V P P + + + L+ +P
Sbjct: 14 PPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSG 73
Query: 406 KV--EEATVEERTPAEPEV--GPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTV 461
+V A +E +P+ GP PAM P A P +S P+P V PA S P+
Sbjct: 74 QVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAV--PASDSPPT--- 128
Query: 462 NASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVA 520
++ + E+ +LA+E+RE+ + ++ + +K E+ A R
Sbjct: 129 ---------------KQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREK 173
Query: 521 EERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREE 577
+ + RR E +RL+AEQ R E+ QRQ E+ +ER EA + K+ A +R++
Sbjct: 174 QLQERRRRLEEQRLKAEQRRAALEERQRQKLEKN-KERYEAAIQRSVKKTWAEIRQQ 229
Score = 58.2 bits (139), Expect = 3e-08
Identities = 59/227 (25%), Positives = 98/227 (43%), Gaps = 33/227 (14%)
Query: 401 RAPLVKVEEATVEERTPAEPEVGPAA-PAMAPAPASAPAPASAPAPAPV--------PTP 451
RA L V RTP EP P P+ P P SA P + P P P
Sbjct: 6 RAELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLP 65
Query: 452 AMVSAPSSTV---------NASASVKTSAGTTDPEEATRLLAEKRRLAREQ--------- 493
+PS V + +S S G T P R RR ++
Sbjct: 66 LEPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASDS 125
Query: 494 --REKEERERREQEELERQKREELAQRVAEERTT--RREEESRRLEAEQAREKEEQLQRQ 549
++E ++ E+ +L +++REE A+ +A ++ +EE+++ L +Q +E+ +L+ Q
Sbjct: 126 PPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQ 185
Query: 550 AEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQER 596
+A + R E QRQK E+ + R EA +++ +K + Q+R
Sbjct: 186 -RLKAEQRRAALEERQRQKLEKNKERYEA-AIQRSVKKTWAEIRQQR 230
Score = 50.8 bits (120), Expect = 4e-06
Identities = 66/288 (22%), Positives = 122/288 (42%), Gaps = 36/288 (12%)
Query: 421 EVGPAAPAMAPA---PASAPAPASAPAPAPVPTPAMV-----SAPSSTVNASASVKTSAG 472
E+G AP A P P+P P+P P P A+V P + NA++S +
Sbjct: 8 ELGAGAPPAVVARTPPEPRPSPEGDPSPPPPPMSALVPDTPPDTPPAMKNATSSKQLPL- 66
Query: 473 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEES- 531
+PE + + + +E+ E + R R+ R + + + S
Sbjct: 67 --EPESPSGQVGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRRSSQPSPTAVPASD 124
Query: 532 ---RRLEAEQAREKEEQLQRQAEERALR---------EREEAERAQRQKE-EEARVREEA 578
+ E ++A E+ + + + EERA E+EE +A R+K+ +E R R E
Sbjct: 125 SPPTKQEVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEE 184
Query: 579 ERVR-QEREKHFQREEQERLERKKRLEE--IMKRTRRTEATDKKTSDQRNGDIAKGALTG 635
+R++ ++R + ++++LE+ K E I + ++T A ++ G + +
Sbjct: 185 QRLKAEQRRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHS--SP 242
Query: 636 GTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNEN 683
G + S C+ +A V P V S +K +S+ L P+ N
Sbjct: 243 GHKTSGSRCSVSA------VNLPKHVDSIINKRLSKSSATLWNSPSRN 284
Score = 37.4 bits (85), Expect = 0.051
Identities = 26/110 (23%), Positives = 56/110 (50%), Gaps = 14/110 (12%)
Query: 64 DDRQRLARER-------REEREKQLAAREIVWLEREERARQHYEKHLEE-----RKKRLE 111
++++RL +++ REE E+Q RE +++E+ RQ K LEE RK +
Sbjct: 667 EEQERLQKQKEEAEARSREEAERQRLERE-KHFQQQEQERQERRKRLEEIMKRTRKSEVS 725
Query: 112 EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWS 161
E +QK++ + A + ++ + R + + +++ ++P + +WS
Sbjct: 726 ETKQKQDSKEANANGSSPEPVKAVEARSPGLQKEAVQK-EEPIPQEPQWS 774
Score = 35.4 bits (80), Expect = 0.20
Identities = 24/95 (25%), Positives = 50/95 (52%), Gaps = 7/95 (7%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREE---RARQHYEKHLEERKKRLEEQRQK--EERR 120
R+R +E RE+ + + +E + ++EE R+R+ E+ ER+K ++Q Q+ E R+
Sbjct: 651 RRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQRLEREKHFQQQEQERQERRK 710
Query: 121 R--AAVEEKRRQRLEEDKERHEAVVRRTMERSQKP 153
R ++ R+ + E K++ ++ S +P
Sbjct: 711 RLEEIMKRTRKSEVSETKQKQDSKEANANGSSPEP 745
>gi|22758136 MAP7 domain containing 2 [Homo sapiens]
Length = 732
Score = 279 bits (713), Expect = 8e-75
Identities = 216/590 (36%), Positives = 317/590 (53%), Gaps = 94/590 (15%)
Query: 61 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
L+ D+RQRLA+ERREEREK LAARE LE+++RAR YEK +EER ++LEEQRQ+E+++
Sbjct: 49 LKSDERQRLAKERREEREKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQK 108
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
RAAVEEKR+Q+L E++ER EA++RR++ER+Q+ + K ++SWG L P H A D+
Sbjct: 109 RAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELK-KKYSWGAPLAIGPGGHDAC-DKL 166
Query: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARS 240
S STM+L K +P ++KRLSSS+ + SPDR V RL
Sbjct: 167 STSTMSLPKPTEPPMNKRLSSSTVAISYSPDRVFH---------VCPRL----------- 206
Query: 241 KSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSS---RRRIIHGTASYKKE 297
A P+ YK++ +RN +++ K T G+ + + G AS ++
Sbjct: 207 ----------APLGPLNPSYKSSPTRN-IEKKKATSTSTSGAGDVGKEALSGGEASLVEK 255
Query: 298 RERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAA 357
+R G R A S P R + S +P P +P S + +
Sbjct: 256 VKR--------GQRTATSLPVVNFGSPLRRCEF--SGGIPKRPSSP-VISKTATKAYPQS 304
Query: 358 PAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTP 417
P +PP PG+ PVK + + P+++ +K E S K R E T
Sbjct: 305 PKTTKPPYPGS--PVKYRLPALSGQDMPKRKAEK---EKSNKER------------EGTL 347
Query: 418 AEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPE 477
A+ GP + A A A N++A K +AGTTD
Sbjct: 348 AQQAAGPQGEEALEKHVVDKHASEKHAAA---------AGGKAENSAALGKPTAGTTDAG 398
Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER-------------T 524
EA ++LAEKRR AR Q+E+EE+ER E+EE +R +REEL ++ EER
Sbjct: 399 EAAKILAEKRRQARLQKEQEEQERVEKEEQDRLEREELKRKAEEERLRLEEEARKQEEER 458
Query: 525 TRREEESRRLEAEQAREKEEQLQRQAEERAL----REREEAERAQRQKEEEA---RVREE 577
R+EEE ++ E E+ R+ E+ +R+AEE L +E+E+ E+A +K++EA + RE
Sbjct: 459 KRQEEEKKKQEGEEKRKAGEEAKRKAEEELLLKEKQEQEKQEKAMIEKQKEAAETKAREV 518
Query: 578 AERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDK-KTSDQRNG 626
AE++R ERE+ + EQERLERKKR++EIMKRTR+++ + K D + G
Sbjct: 519 AEQMRLEREQIMLQIEQERLERKKRIDEIMKRTRKSDVPPQVKKEDPKVG 568
Score = 52.8 bits (125), Expect = 1e-06
Identities = 48/166 (28%), Positives = 73/166 (43%), Gaps = 33/166 (19%)
Query: 441 SAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLA--EKRRLAREQREKEE 498
S P T S P A V+TS P+ L E++RLA+E+R EE
Sbjct: 8 SGTGSRPEGTARGTSLPGKIAEPGA-VRTSQPNYRPQGMEGFLKSDERQRLAKERR--EE 64
Query: 499 RER----REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERA 554
RE+ REQ+ LE+QKR L E R+ EE R
Sbjct: 65 REKCLAAREQQILEKQKRARLQYEKQMEERWRKLEEQR---------------------- 102
Query: 555 LREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
+RE+ +RA +++ + ++REE ER+ + +R +Q L++K
Sbjct: 103 --QREDQKRAAVEEKRKQKLREEEERLEAMMRRSLERTQQLELKKK 146
Score = 48.1 bits (113), Expect = 3e-05
Identities = 39/125 (31%), Positives = 66/125 (52%), Gaps = 11/125 (8%)
Query: 33 KNASSRPASAISGQNNNHSG-NKPDPPPVLRVDDRQRLARERREER-EKQLAAREIVWLE 90
K+AS + A+A G+ N + KP + + LA +RR+ R +K+ +E V E
Sbjct: 367 KHASEKHAAAAGGKAENSAALGKPTAGTTDAGEAAKILAEKRRQARLQKEQEEQERVEKE 426
Query: 91 REERA-RQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMER 149
++R R+ ++ EE + RLEE+ +K+E EE++RQ EE+K++ E +R
Sbjct: 427 EQDRLEREELKRKAEEERLRLEEEARKQE------EERKRQ--EEEKKKQEGEEKRKAGE 478
Query: 150 SQKPK 154
K K
Sbjct: 479 EAKRK 483
Score = 47.8 bits (112), Expect = 4e-05
Identities = 51/201 (25%), Positives = 87/201 (43%), Gaps = 18/201 (8%)
Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
PE R + ++A + + + +E + + QR+A+E RREE + L
Sbjct: 14 PEGTARGTSLPGKIAEPGAVRTSQPNYRPQGMEGFLKSDERQRLAKE---RREEREKCLA 70
Query: 536 AEQAREKEEQLQRQAE-ERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
A + + E+Q + + + E+ + ER QRQ+E++ R E E+ K REE+
Sbjct: 71 AREQQILEKQKRARLQYEKQMEERWRKLEEQRQREDQKRAAVE------EKRKQKLREEE 124
Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKP 654
ERLE R ++RT++ E K + A A+ G + +T+ KP
Sbjct: 125 ERLEAMMR--RSLERTQQLELKKKYSWG------APLAIGPGGHDACDKLSTSTMSLPKP 176
Query: 655 VGSPHVVTSHQSKVTVESTPD 675
P S V + +PD
Sbjct: 177 TEPPMNKRLSSSTVAISYSPD 197
>gi|147903302 MAP7 domain containing 3 [Homo sapiens]
Length = 876
Score = 155 bits (392), Expect = 1e-37
Identities = 208/863 (24%), Positives = 346/863 (40%), Gaps = 166/863 (19%)
Query: 2 AELGAGGDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPD-PPPV 60
A GAGG A A + K + K++ +R A+ S N S KP +
Sbjct: 6 AAAGAGGSPSLRELRARMVAAANEIAKERRKQDVVNRVATHSS---NIRSTFKPVIDGSM 62
Query: 61 LRVDDRQRLARERREEREKQLAA-REIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
L+ D +QRLARERREE+ +Q A +E LE+E + + YEK +EER+++L+E+++KEE+
Sbjct: 63 LKNDIKQRLARERREEKRRQQDANKETQLLEKERKTKLQYEKQMEERQRKLKERKEKEEQ 122
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ-KPKQKHNRWSWGGSLHGSPSIHSADPD 178
RR A EEKR Q+ E KE+ A++ RT+ER + + RWSWGGS + +A +
Sbjct: 123 RRIAAEEKRHQKDEAQKEKFTAILYRTLERRRLADDYQQKRWSWGGSAMANSESKTA--N 180
Query: 179 RRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLA 238
+RS ST L + +I +++ SSA L NS + + SS +NR + HS +
Sbjct: 181 KRSASTEKLEQGTSALI-RQMPLSSAGLQNS---VAKRKTDKERSSSLNRRDSNLHS--S 234
Query: 239 RSKSTAALSGEAASCSPIIMPYKAAHSR--------------NSMDRP----------KL 274
K A + +M Y R ++M P +
Sbjct: 235 TDKEQAERKPRVTGVTNYVMQYVTVPLRKCTSDELRAVMFPMSTMKIPPQTKVEESPLEK 294
Query: 275 FVTPPEGS---------------SRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNP 319
TPP+ S S E ++ ++ VS +
Sbjct: 295 VETPPKASVDAPPQVNVEVFCNTSMEASPKAGVGMAPEVSTDSFPVVSVDVSPVVSTYDS 354
Query: 320 KARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVE 379
+ A L + + L P+ + P + AP +V S + V E E
Sbjct: 355 EMSMDASPELSIEALPKVDLETVPKVSIVASPEASLEAPPEV---SLEALPEVSVEAAPE 411
Query: 380 PEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPA---SA 436
+ P K +VA + S+KG + EA+ E A P+ A A A A
Sbjct: 412 GSLEAPPKGSAEVAPKESVKGSPK--ESMEASPEAMVKASPKTSLEASMEASPKAKARDA 469
Query: 437 PAPASAPAPAPVP-TPAMVSAPSSTVNASASVKTSAGTTDPEEATR-------------- 481
P + A +P +S+ + S+S + + G P R
Sbjct: 470 PKKSEMDKQALIPIAKKRLSSYTECYKWSSSPENACGLPSPISTNRQIQKNCPPSPLPLI 529
Query: 482 ------------LLAEKRRLAREQREKEERERREQEELERQKREELAQR----------- 518
++ + L+ + ++++E + E L+QR
Sbjct: 530 SKQSPQTSFPYKIMPIQHTLSVQSASSTVKKKKETVSKTTNRCEALSQRHMIYEESGNKS 589
Query: 519 ----VAEERTTRREEESRRLEAEQAREKEEQLQR---------------------QAEE- 552
+ E T+ E RRL EQ ++EE+ QR QAE+
Sbjct: 590 TAGIMNAEAATKILTELRRLAREQREKEEEERQREEMQQRVIKKSKDMAKEAVGGQAEDH 649
Query: 553 ---------------RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERL 597
+ ++E+ E ++ + + + +EEA++ ++E E+ + QERL
Sbjct: 650 LKLKDGQQQNETKKKKGWLDQEDQEAPLQKGDAKIKAQEEADKRKKEHERIMLQNLQERL 709
Query: 598 ERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTE----------VSALPCTTN 647
ERKKR+EEIMKRTR+T+ K ++ + DI + A E SA+ T
Sbjct: 710 ERKKRIEEIMKRTRKTDVNASKVTETSSHDIYEEAEADNEESDKDSLNEMFPSAILNGTG 769
Query: 648 APGNGKPVGSPHVVTSHQSKVTVESTPDLEKQP---------NENGVSVQNENFEEIINL 698
+P K + +H+ + T + K+P N S+++ + +E+++
Sbjct: 770 SPTKFKMPFNNAKKMTHKLVFLEDGTSQVRKEPKTYFNGDLKNFRQKSMKDTSIQEVVSR 829
Query: 699 PIG-------SKPSRLDVTNSES 714
P +K + D TN+ S
Sbjct: 830 PSSKRMTSHTTKTRKADETNTTS 852
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 90.1 bits (222), Expect = 7e-18
Identities = 56/143 (39%), Positives = 91/143 (63%), Gaps = 6/143 (4%)
Query: 477 EEATRLLAEKRRLAREQREKE---ERERREQEELERQKREE-LAQRVAEERTTRREEESR 532
E +L E+RR +E+RE++ E+E R ++ L+RQ+ EE L QR+ E+ RRE+E R
Sbjct: 486 ERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEER 545
Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQER-EKHFQR 591
R E RE+E++L+++ E+ L+ +E R Q K EE R ++ +R ++ER E+ +R
Sbjct: 546 R-EQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604
Query: 592 EEQERLERKKRLEEIMKRTRRTE 614
EE ERLE+++R E+ +KR E
Sbjct: 605 EEVERLEQEERREQRLKREEPEE 627
Score = 86.7 bits (213), Expect = 7e-17
Identities = 60/142 (42%), Positives = 88/142 (61%), Gaps = 11/142 (7%)
Query: 482 LLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRRL--EA 536
L E+ +L RE+REK +ERER+ +EE E Q+ EE Q + EER TRR +E R +
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEE--QLLGEERETRRRQELERQYRKE 1083
Query: 537 EQAREKEEQLQRQAEE---RALREREEAERAQRQKEEEARVREEAE-RVRQEREKHFQRE 592
E+ +++EEQL R+ E R RER+ E + Q+EEE +REE E R RQE E+ ++ E
Sbjct: 1084 EELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Query: 593 EQERLERKKRLEEIMKRTRRTE 614
E+ + E ++ L E ++ RR E
Sbjct: 1144 EEVQQEEEQLLREEPEKRRRQE 1165
Score = 86.3 bits (212), Expect = 1e-16
Identities = 58/168 (34%), Positives = 94/168 (55%), Gaps = 14/168 (8%)
Query: 477 EEATRLLAEKRRLAREQREKEERER-----REQEEL-ERQKREELAQRVAEERTTRREEE 530
EE R E+RR +E+RE++E R REQEE E+Q R E + E++ R +EE
Sbjct: 311 EEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEE 370
Query: 531 SRR---LEAEQAREKEEQLQRQAE---ERALREREEAERAQRQKEEEARVREEAERVRQE 584
RR L EQ +E+QL+R+ + E+ LR ++ R Q+ + E+ RE+ R QE
Sbjct: 371 ERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQE 430
Query: 585 REKHFQREEQERLERKKRLEEIMKR--TRRTEATDKKTSDQRNGDIAK 630
E+H Q+ EQER E++ + E+ +R +R E T++ ++R + +
Sbjct: 431 EERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478
Score = 86.3 bits (212), Expect = 1e-16
Identities = 56/141 (39%), Positives = 86/141 (60%), Gaps = 12/141 (8%)
Query: 482 LLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQ 538
L E+ +L RE+ EK +ERER+ +EE E Q+ EE R E+ R+E E + E E+
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEE 1145
Query: 539 AREKEEQLQRQAEERALREREEAERAQR-----QKEEEARVREEAERVRQEREKHFQREE 593
+++EEQL R+ E+ R R+E ER R Q+EEE +REE E+ RQERE+ ++ E
Sbjct: 1146 VQQEEEQLLREEPEK--RRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR--E 1201
Query: 594 QERLERKKRLEEIMKRTRRTE 614
+E L+R+KR + +R++
Sbjct: 1202 EEELQRQKRKQRYRDEDQRSD 1222
Score = 85.9 bits (211), Expect = 1e-16
Identities = 62/159 (38%), Positives = 90/159 (56%), Gaps = 19/159 (11%)
Query: 475 DPEEATRLLAEKR-------RLAREQREKEERERREQEELERQKREELAQRVAEERTTRR 527
+PE+ R EK+ + EQ +EERE+R ++E ERQ R++ + EE+ R
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 528 EEESRRL-EAEQAREKEEQLQRQ-----AEERALREREEAERAQR-----QKEEEARVRE 576
E E RRL E E+ +EE+LQ++ EER R R+E ER R Q+EEE +RE
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 577 EAE-RVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
E E R RQERE+ + EE+ + E ++ L E ++ RR E
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQE 1135
Score = 84.3 bits (207), Expect = 4e-16
Identities = 57/146 (39%), Positives = 88/146 (60%), Gaps = 11/146 (7%)
Query: 478 EATRLLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
E +L E+ +L RE+REK +ERER+ +++ + Q++EE E+ R+E E +
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYR 991
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQK-----EEEARVREEAERVR-QEREKH 588
E E+ +++EEQL R EER R R+E ER R+K EEE +REE E+ R QERE+
Sbjct: 992 EEEELQQEEEQLLR--EEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049
Query: 589 FQREEQERLERKKRLEEIMKRTRRTE 614
++ EE+ + E ++ L E + RR E
Sbjct: 1050 YREEEELQQEEEQLLGEERETRRRQE 1075
Score = 84.0 bits (206), Expect = 5e-16
Identities = 52/147 (35%), Positives = 87/147 (59%), Gaps = 7/147 (4%)
Query: 485 EKRRLAREQ--REKEERERREQEELERQKREELAQR-VAEERTTRREEESRR---LEAEQ 538
+++RL REQ R K+E ERREQ+E R+++E Q+ E+ RRE+E RR L EQ
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355
Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ-EREKHFQREEQERL 597
E+ EQ R+ +E RE++ Q ++E++ R ++ R +Q RE+ +RE+Q R
Sbjct: 356 EEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 415
Query: 598 ERKKRLEEIMKRTRRTEATDKKTSDQR 624
E++ R E+ ++R + E ++K +R
Sbjct: 416 EQQLRREQQLRREQEEERHEQKHEQER 442
Score = 83.6 bits (205), Expect = 6e-16
Identities = 68/182 (37%), Positives = 93/182 (51%), Gaps = 33/182 (18%)
Query: 477 EEATRLLAEKRRLAREQREK---------EERERREQEELERQKREELAQRVAEERTTRR 527
E R L E+ R RE+ E EERE R ++ELERQ R+E + EE+ R
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 528 EEESRR--------LEAEQAREKEEQLQRQAEERALREREEAERAQR-----QKEEEARV 574
E E RR E E+ +++EEQL R EER R R+E ER R Q+EEE +
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLR--EEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 575 REEAE-RVRQEREKHFQREEQ--------ERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
REE E R RQE E+ ++ EE+ R E++KR +E ++ R E ++ QR
Sbjct: 1155 REEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRY 1214
Query: 626 GD 627
D
Sbjct: 1215 RD 1216
Score = 83.2 bits (204), Expect = 8e-16
Identities = 55/166 (33%), Positives = 99/166 (59%), Gaps = 19/166 (11%)
Query: 477 EEATRL---LAEKRRLAREQREKEER--ERREQEELERQKREELAQRVAEER---TTRRE 528
EE RL L +++L REQ E+ E+ +R E++ LE+++RE+ +R EER +RE
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582
Query: 529 EESR--RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE--EAERVRQE 584
EE R RL+ EQ E++L+R+ ER +E +R +R++ EE R ++ ++E +
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEER 642
Query: 585 REKHFQREEQERLERK-------KRLEEIMKRTRRTEATDKKTSDQ 623
R++ +RE+QER E++ +RLE+ +KR E +++ +++
Sbjct: 643 RQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Score = 80.9 bits (198), Expect = 4e-15
Identities = 55/158 (34%), Positives = 95/158 (60%), Gaps = 10/158 (6%)
Query: 477 EEATRLLAEKRRLAREQREKEERERR-EQEEL--ERQKREELAQRVAEERTTRR-EEESR 532
+E +L E+ + RE +E+EE+ R+ E++EL ERQ+ E+ QR+ E+ RR +EE R
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 533 RLEAEQAREKEEQLQRQAEERAL---REREEAERAQRQKEEEARVREEAERVRQE---RE 586
R + E+ RE++E+ ++Q E R RE+EE Q ++E+E RE+ R QE RE
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 587 KHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+ +RE+Q R E++ R E+ ++R ++ + +Q+
Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 412
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/159 (35%), Positives = 93/159 (58%), Gaps = 21/159 (13%)
Query: 486 KRRLAREQREK-------EERERREQE----ELERQKREELAQR----VAEERTTRREEE 530
++RL REQ E+ EE ER EQE +L+R + EE +R EER ++E
Sbjct: 444 EQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERR 503
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEAR----VREEAERVRQE-R 585
++L EQ +E++L+RQ EE L++R +E+ R+++EE R REE +R+ QE R
Sbjct: 504 EQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERR 563
Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E+ +RE++ER ++ + EE +R +R + ++ +QR
Sbjct: 564 EQRLKREQEERRDQLLKREE-ERRQQRLKREQEERLEQR 601
Score = 79.7 bits (195), Expect = 9e-15
Identities = 59/158 (37%), Positives = 86/158 (54%), Gaps = 30/158 (18%)
Query: 485 EKRRLAREQRE--------KEERERRE---------QEELER-----QKREELAQRVAEE 522
++RR ++EQR +EER+RR QE+L + Q+ EE QR E
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREERE 919
Query: 523 RTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQR------QKEEEARVRE 576
+ R+E+E + E EQ +++EEQL R EER R R+E ER R QKEE+ E
Sbjct: 920 KRRRQEQERQYREEEQLQQEEEQLLR--EEREKRRRQERERQYRKDKKLQQKEEQLLGEE 977
Query: 577 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
+R RQEREK ++ EE+ + E ++ L E ++ RR E
Sbjct: 978 PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQE 1015
Score = 79.7 bits (195), Expect = 9e-15
Identities = 48/154 (31%), Positives = 87/154 (56%), Gaps = 6/154 (3%)
Query: 476 PEEATRLLAEKRRLAREQRE--KEERERREQEELERQKREELAQRVAEERTTRREEESRR 533
P +L E++ L E+ E +EERE+R ++E ERQ REE + EE+ R E E RR
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRR 952
Query: 534 LEAEQAREKEEQLQRQAEERALRE----REEAERAQRQKEEEARVREEAERVRQEREKHF 589
+ + + ++++ +Q EE+ L E R ER ++ +EEE +EE + +R+EREK
Sbjct: 953 RQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRR 1012
Query: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
++E + + +K L++ ++ R E ++ ++
Sbjct: 1013 RQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046
Score = 79.7 bits (195), Expect = 9e-15
Identities = 44/135 (32%), Positives = 82/135 (60%), Gaps = 7/135 (5%)
Query: 477 EEATRLLAEKRRLAREQR------EKEERERREQEELERQKREELAQRVAEERTTRREEE 530
EE R E+ +L R++R E++ R RE+++L RQ+R+ + + R R E++
Sbjct: 1728 EEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQ 1787
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
R E+++ +EEQL+++ EE+ LR ++ + R +EE+ ++ E+ +R+RQER++ ++
Sbjct: 1788 LRSQESDRKFREEEQLRQEREEQQLRPQQR-DGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Query: 591 REEQERLERKKRLEE 605
EEQ + K R EE
Sbjct: 1847 AEEQFATQEKSRREE 1861
Score = 79.3 bits (194), Expect = 1e-14
Identities = 49/161 (30%), Positives = 91/161 (56%), Gaps = 11/161 (6%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
+P+ L E+ +L + +R++ RER+E+E+ +++ R E R +E R ++E RR
Sbjct: 264 EPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE 323
Query: 535 EAEQAREKEE----QLQRQAEERA----LREREEAERAQ---RQKEEEARVREEAERVRQ 583
+ E+ ++EE QL+R+ EER RE+EE R Q R++EEE R ++ +
Sbjct: 324 QQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQL 383
Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
RE+ +RE+Q R E++ R E+ ++R ++ + +Q+
Sbjct: 384 RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ 424
Score = 79.3 bits (194), Expect = 1e-14
Identities = 55/160 (34%), Positives = 91/160 (56%), Gaps = 17/160 (10%)
Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
PEE + E+RR R +REKE + E+E+L+R++R AQ++ EE +E++ RR
Sbjct: 812 PEEEEK---EQRRRQRREREKELQFLEEEEQLQRRER---AQQLQEEEDGLQEDQERRRS 865
Query: 536 AEQAREKEEQLQRQAEER----------ALREREEAERAQRQKEEEARVREEAE-RVRQE 584
EQ R+++ + Q + E + AL+E+ E+ Q+EEE REE E R RQE
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925
Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+E+ ++ EEQ + E ++ L E ++ RR E + D++
Sbjct: 926 QERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK 965
Score = 79.0 bits (193), Expect = 2e-14
Identities = 54/163 (33%), Positives = 94/163 (57%), Gaps = 22/163 (13%)
Query: 481 RLLAEKRRLAREQREKEERERR-----EQEELERQKREELA----QRVAEERTTRR---- 527
R L E RR RE+++++ RER+ E+EE E +KRE + +++ EE R+
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 528 --EEESRRLEAEQAR----EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERV 581
EE+ R+LE ++ R E+E+Q QR E+ LR ++E ER ++Q EE +E E+
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ-EERREQQERREQQ 331
Query: 582 RQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+ RE+ +RE++ER E++ R E+ + RR + ++ ++R
Sbjct: 332 EERREQQLRREQEERREQQLRREQ--EEERREQQLRREQEEER 372
Score = 79.0 bits (193), Expect = 2e-14
Identities = 47/142 (33%), Positives = 85/142 (59%), Gaps = 6/142 (4%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
E+++L RE+RE+ +RR QE + + EE + EE+ RR+E R+ E+ R +E+
Sbjct: 1316 EEKQLLREEREE---KRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQ 1372
Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE--RLERKKR 602
+ EE+ LR R+E ER ++E++ R +E +++RQ+R++ F+ EEQ+ R ER ++
Sbjct: 1373 GRKFLEEEQRLR-RQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Query: 603 LEEIMKRTRRTEATDKKTSDQR 624
E ++ RR E K +++
Sbjct: 1432 FREEEQQVRRQERERKFLEEEQ 1453
Score = 78.2 bits (191), Expect = 3e-14
Identities = 45/148 (30%), Positives = 91/148 (61%), Gaps = 9/148 (6%)
Query: 483 LAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
L +++L REQ+ + E++ R +++L R+++ Q++ E+ RRE+E R E + +E+
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 543 EEQ-LQRQAEERA--LREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
EQ L+R+ EER L+ EE ER ++++ ++ R++ E + RE+ + EE+ER E+
Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEE---ERRERWLKLEEEERREQ 499
Query: 600 KKRLEEIMKR---TRRTEATDKKTSDQR 624
++R E+ ++R RR + ++ ++R
Sbjct: 500 QERREQQLRREQEERREQRLKRQEEEER 527
Score = 78.2 bits (191), Expect = 3e-14
Identities = 54/151 (35%), Positives = 95/151 (62%), Gaps = 15/151 (9%)
Query: 483 LAEKRRLAREQR-EKEERERREQEELERQKREELAQRVAEERTT--RREEESRRLEAEQA 539
L +++L REQ+ +E+ E R +++ E+++RE+ +R EER +REEE+ R E E+
Sbjct: 413 LRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER- 471
Query: 540 REKEEQLQRQAEERALRER----EEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
+++QL+R EE RER EE ER ++Q+ E ++R E E R++R K ++EE+E
Sbjct: 472 --RKQQLKRDQEEER-RERWLKLEEEERREQQERREQQLRREQEERREQRLK--RQEEEE 526
Query: 596 RLERKKRLEEIMKRTR--RTEATDKKTSDQR 624
RL+++ R E+ ++R + R E K+ ++R
Sbjct: 527 RLQQRLRSEQQLRREQEERREQLLKREEEKR 557
Score = 77.0 bits (188), Expect = 6e-14
Identities = 51/158 (32%), Positives = 90/158 (56%), Gaps = 12/158 (7%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
EE T ++RR + +R++EE R +LE ++R E +R E+ RRE+E RR +
Sbjct: 461 EEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER--REQQLRREQEERREQR 518
Query: 537 EQAREKEEQLQRQ--AEERALREREEAERAQRQKEEEARVREEAERVRQEREKH------ 588
+ +E+EE+LQ++ +E++ RE+EE ++EEE R+ +E R +RE+
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQL 578
Query: 589 FQREEQERLERKKRLEE--IMKRTRRTEATDKKTSDQR 624
+REE+ R +R KR +E + +R +R E + ++R
Sbjct: 579 LKREEERRQQRLKREQEERLEQRLKREEVERLEQEERR 616
Score = 76.3 bits (186), Expect = 1e-13
Identities = 65/172 (37%), Positives = 100/172 (58%), Gaps = 34/172 (19%)
Query: 483 LAEKRRLAREQRE-----KEERERREQ----EELERQ---KREELAQRVAEER----TTR 526
L +++L REQ E K E+ERREQ E+ ER+ KREE +R +ER R
Sbjct: 419 LRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478
Query: 527 REEESRR-----LEAEQARE----KEEQLQRQAEER---ALREREEAERAQRQKEEEARV 574
+EE RR LE E+ RE +E+QL+R+ EER L+ +EE ER Q++ E ++
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQL 538
Query: 575 REEAERVRQEREKHFQREEQERLERKKRLEEIMKRTR--RTEATDKKTSDQR 624
R E E + RE+ +REE++RLE+++R E+ +KR + R + K+ ++R
Sbjct: 539 RREQE---ERREQLLKREEEKRLEQERR-EQRLKREQEERRDQLLKREEERR 586
Score = 75.9 bits (185), Expect = 1e-13
Identities = 59/158 (37%), Positives = 81/158 (51%), Gaps = 29/158 (18%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQ----EELERQKREELAQRVAEERTTR--REEE 530
EE RL E+RR R +RE+ E ERR+Q EE E +++++L + E R R REEE
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664
Query: 531 SRRLEAEQAREKEEQLQRQ--AEERALRERE-------------EAERAQRQ-------- 567
RLE RE EE+ + Q AEE + RE E+E RQ
Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724
Query: 568 KEEEARVREEAERVRQEREKHFQREEQERLERKKRLEE 605
K+E R R+E E R+ RE Q +E+ER R+++ EE
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEE 762
Score = 75.5 bits (184), Expect = 2e-13
Identities = 56/164 (34%), Positives = 88/164 (53%), Gaps = 17/164 (10%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQE-----ELERQKREELAQRVAEERTTRREEES 531
E+ R E+ R ++ R ++E ERREQ+ +L R+++ Q++ E+ RRE++
Sbjct: 348 EQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQL 407
Query: 532 RR---LEAEQAREKEEQLQR-QAEERALREREEAERAQRQKEEEARVR------EEAERV 581
RR L EQ +E+QL+R Q EER ++ E+ R QR K E+ R EE ER
Sbjct: 408 RREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467
Query: 582 RQEREKHFQR--EEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
QER K + +E+ER ER +LEE +R ++ + +Q
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Score = 75.5 bits (184), Expect = 2e-13
Identities = 51/154 (33%), Positives = 88/154 (57%), Gaps = 8/154 (5%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR--- 533
++ R E+RR + +RE+EE R +Q E+Q R E Q++ E+ RRE++ RR
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE--QQLRREQQLRREQQLRREQQ 406
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ--EREKHFQR 591
L EQ +E+QL+R+ + R +E E E+ Q+ E R++ E E R +RE+ +R
Sbjct: 407 LRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETER 466
Query: 592 EEQERLERK-KRLEEIMKRTRRTEATDKKTSDQR 624
EQER +++ KR +E +R R + +++ +Q+
Sbjct: 467 HEQERRKQQLKRDQEEERRERWLKLEEEERREQQ 500
Score = 75.5 bits (184), Expect = 2e-13
Identities = 46/157 (29%), Positives = 87/157 (55%), Gaps = 8/157 (5%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERER--REQEELERQKREELAQRVAEERTTRREEESR 532
+ ++ R E++ L EQ+ ++ER R RE+E+L +++ E+ R +R EE+
Sbjct: 1435 EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQL 1494
Query: 533 RLEAEQAREKEEQLQRQAEERA-LREREEAERAQRQK-----EEEARVREEAERVRQERE 586
R + + +E++L+ Q ER L E ++ R QRQ+ E++ R +E ++ RQ+R+
Sbjct: 1495 RRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554
Query: 587 KHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
+ F+ EEQ R ER+++ +R R+ ++K Q
Sbjct: 1555 RKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQ 1591
Score = 75.5 bits (184), Expect = 2e-13
Identities = 52/159 (32%), Positives = 92/159 (57%), Gaps = 13/159 (8%)
Query: 477 EEATRLLAEKRRLAREQREKE-----ERERREQEELERQKREELAQRVAEERTTRREEES 531
E + L E+ +L R++RE++ +R+ RE+E+L ++ E+ +R +R R EE+
Sbjct: 1640 ERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQ 1699
Query: 532 RRLEAEQAR--EKEEQLQRQAEERALRE----REEAERAQRQKEEEARVREEAERVRQER 585
R + + + ++E+QL+RQ ER RE R+E E+ Q +++E R E E++R ER
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E+ Q QER +RK R EE +++ R + + SD++
Sbjct: 1760 EEQ-QLRRQER-DRKFREEEQLRQEREEQQLRSQESDRK 1796
Score = 75.1 bits (183), Expect = 2e-13
Identities = 46/149 (30%), Positives = 90/149 (60%), Gaps = 9/149 (6%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ + L E++RL R++RE+ + +E+++L Q+RE+ ++ + + E++ R E
Sbjct: 1371 EQGRKFLEEEQRLRRQERER--KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 537 EQA-REKEEQLQRQAEERALRE-----REEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
++ RE+E+Q++RQ ER E R+E R R++E+ + REE + RQER++ F
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFL 1488
Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKK 619
EEQ+ L R++R + ++ R++ ++K
Sbjct: 1489 EEEQQ-LRRQERDRKFREQELRSQEPERK 1516
Score = 74.7 bits (182), Expect = 3e-13
Identities = 54/168 (32%), Positives = 88/168 (52%), Gaps = 17/168 (10%)
Query: 477 EEATRLLAEKR--RLAREQRE------KEERERREQEELERQKREELAQRVAEERTTRRE 528
EE RL E+R RL REQ E K E ERR Q+ L+R++ E L QR+ E R E
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERR-QQRLKREQEERLEQRLKREEVERLE 611
Query: 529 EESR---RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE-----R 580
+E R RL+ E+ E+ Q ++EE+ R +++ R Q+++ E+ REE E R
Sbjct: 612 QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQR 671
Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDI 628
+++E E+ + +E E+++ E I R + + + +D R +
Sbjct: 672 LKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKV 719
Score = 74.3 bits (181), Expect = 4e-13
Identities = 55/161 (34%), Positives = 90/161 (55%), Gaps = 21/161 (13%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
EE +L E+ R RE E++ + RE+++L RQ+R+ + + EE+ RR+E R+
Sbjct: 1450 EEEQQLRQERHRKFRE--EEQLLQEREEQQLHRQERDR--KFLEEEQQLRRQERDRKFRE 1505
Query: 537 EQAR---------EKEEQLQRQAEERALREREE----AERAQRQKEEEARVREEAERVRQ 583
++ R E+E+QL RQ +R + E+ ER Q+++++ R E E++RQ
Sbjct: 1506 QELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQ 1565
Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
ERE+ Q QER +RK RLEE ++ RR E K D++
Sbjct: 1566 EREEQ-QLSRQER-DRKFRLEE--QKVRRQEQERKFMEDEQ 1602
Score = 73.9 bits (180), Expect = 5e-13
Identities = 52/161 (32%), Positives = 90/161 (55%), Gaps = 19/161 (11%)
Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
P+E E L R+ RE+++++RRE+++ Q+ EE R E T R+EE + E
Sbjct: 205 PDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRE--TVLRKEEEKLQE 262
Query: 536 AEQAR-----EKEEQLQRQAEERALREREEAERAQ----------RQKEEEARVREEAER 580
E R E+EEQL++ + RER+E E+ Q R++EEE R ++E R
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Query: 581 VRQER--EKHFQREEQERLERKKRLEEIMKRTRRTEATDKK 619
+QER ++ +RE+Q R E+++R E+ ++R + E +++
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363
Score = 73.9 bits (180), Expect = 5e-13
Identities = 54/163 (33%), Positives = 88/163 (53%), Gaps = 16/163 (9%)
Query: 477 EEATRLLAEKRRLAREQREK---EERERREQEELERQKREE--LAQRVAEERTTRREEES 531
E + E+++L R++RE+ +E ++ ++ELER+ REE L Q +E+ R+E
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Query: 532 RRLEAEQAR--EKEEQLQRQAEERALRE----REEAERAQRQKEEEARVREEAERVRQER 585
+ LE EQ R +E+QL+RQ +R RE R+E E Q + +E R E E++RQER
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQER 1807
Query: 586 EKHFQREEQER-----LERKKRLEEIMKRTRRTEATDKKTSDQ 623
E+ R +Q E + +LEE +R R+ + +Q
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQ 1850
Score = 72.8 bits (177), Expect = 1e-12
Identities = 51/161 (31%), Positives = 83/161 (51%), Gaps = 18/161 (11%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEE----RTTRREEESR 532
E+ R R+ E+ +E+ R+ EE +R +R+E ++ +E R RE++ R
Sbjct: 1350 EQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLR 1409
Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
+ + RE+E+QL RQ +R RE E+ R Q E E + EE +++RQER + F+ E
Sbjct: 1410 QDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ---ERERKFLEEEQQLRQERHRKFREE 1466
Query: 593 EQ----------ERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
EQ R ER ++ E ++ RR E D+K +Q
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQE-RDRKFREQ 1506
Score = 72.4 bits (176), Expect = 1e-12
Identities = 59/208 (28%), Positives = 92/208 (44%), Gaps = 61/208 (29%)
Query: 477 EEATRLLAEKRRLAREQRE--KEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
+E R E+ + +E+ + +EE E+R ++ELERQ REE + EE+ R E+E RR
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193
Query: 535 EAEQAREKEEQLQRQ------------------------------------AEERALRER 558
E E+ +EE+LQRQ E R+
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253
Query: 559 EEAERAQRQK---------EEEARVREEAERVRQEREKHFQREEQ----ERLERKKR--- 602
E+++ RQ E++ R RE+ R Q+R++HF EEQ E+ E K+R
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRK 1313
Query: 603 -------LEEIMKRTRRTEATDKKTSDQ 623
L E + RR + TD+K ++
Sbjct: 1314 SQEEKQLLREEREEKRRRQETDRKFREE 1341
Score = 72.0 bits (175), Expect = 2e-12
Identities = 49/151 (32%), Positives = 88/151 (58%), Gaps = 14/151 (9%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
EE E+++L R++R+++ RE E+++L RQ+R E + + E++ RR E
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFRE--EEQQLRRQER--------ERKFLQEEQQLRRQEL 1721
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE--- 593
E+ +EEQL+++ E+ LR R+E R ++E+ REE + RQER++ F+ EE
Sbjct: 1722 ERKFREEEQLRQETEQEQLR-RQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLR 1780
Query: 594 QERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
QER E++ R +E ++ R E ++ +Q+
Sbjct: 1781 QEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Score = 70.5 bits (171), Expect = 5e-12
Identities = 46/134 (34%), Positives = 79/134 (58%), Gaps = 8/134 (5%)
Query: 487 RRLAREQREKEERER--REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR--EK 542
RR R Q+ +++R+R RE+E+L +++ E+ R +R R EE+ R + ++ + E
Sbjct: 1541 RRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600
Query: 543 EEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE--RLERK 600
E+QL+RQ ++ LR+ E +R R+ E+ + REE + RQER++ F EE + R ER+
Sbjct: 1601 EQQLRRQEGQQQLRQ--ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 601 KRLEEIMKRTRRTE 614
++L R R E
Sbjct: 1659 QQLRHDRDRKFREE 1672
Score = 69.7 bits (169), Expect = 9e-12
Identities = 51/152 (33%), Positives = 87/152 (57%), Gaps = 14/152 (9%)
Query: 477 EEATRLLAEKRRLAREQR-----EKEERERREQEELERQKRE---ELAQRVAEERTTRRE 528
+E R + ++L +++ E E+R R+E+E+ R++ E E Q + EER RR
Sbjct: 954 QERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 529 EE---SRRLEAEQAREKEEQLQRQAEERALREREE--AERAQRQKEEEARVREEAE-RVR 582
+E R + E +E+E+ L+ + E+R L+ERE E + Q+EEE + EE E R R
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRR 1073
Query: 583 QEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
QE E+ +++EE+ + E ++ L E ++ RR E
Sbjct: 1074 QELERQYRKEEELQQEEEQLLREEPEKRRRQE 1105
Score = 69.7 bits (169), Expect = 9e-12
Identities = 47/158 (29%), Positives = 87/158 (55%), Gaps = 9/158 (5%)
Query: 477 EEATRLLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRR 533
EE R E+++L R++R++ EE + R++ E ++ + +E ++ EE R+E E ++
Sbjct: 1752 EEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQ 1811
Query: 534 LEAEQA----REKEEQLQRQAEERALR-EREEAERAQRQKEEEARVREEAERVRQEREKH 588
L +Q R +EEQLQ + +E+ LR ER+ RA+ Q + + R E + + QE E+
Sbjct: 1812 LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
Query: 589 FQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNG 626
+R+E+ER R++ + K +R + S + G
Sbjct: 1872 -RRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKG 1908
Score = 69.3 bits (168), Expect = 1e-11
Identities = 47/160 (29%), Positives = 91/160 (56%), Gaps = 28/160 (17%)
Query: 477 EEATRLLAEKRRLAREQ-----REKEERERREQEELERQKREELAQR-------VAEERT 524
E+ + + ++++L R++ R++ +R+ RE E+L +++ E+ R + EE
Sbjct: 1592 EQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ 1651
Query: 525 TRREEESRRLEAEQARE--KEEQLQRQAEERALRE-------REEAERAQRQKEEEARVR 575
RR+E ++L ++ R+ +EEQL ++ EE+ LR REE ++ +RQ+ E ++
Sbjct: 1652 LRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ 1711
Query: 576 EEAERVRQEREKHFQRE-------EQERLERKKRLEEIMK 608
EE + RQE E+ F+ E EQE+L R++R +I++
Sbjct: 1712 EEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILE 1751
Score = 68.2 bits (165), Expect = 3e-11
Identities = 54/186 (29%), Positives = 91/186 (48%), Gaps = 38/186 (20%)
Query: 477 EEATRLLAEKRRLAREQREKEERER-REQEELERQKRE--ELAQRVAEERTTRR------ 527
+E R LAE + +Q E+R+R R EEL RQ++E E +R AEE +
Sbjct: 142 QEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHET 201
Query: 528 -----EEESRRLEA----EQAREKEEQLQRQAEERALREREEAERAQRQ----KEEEARV 574
EE+ RR E + RE+++Q +R+ ++R +E EE E +R+ KEEE
Sbjct: 202 EEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 575 REEAERVRQ----------------EREKHFQREEQERLERKKRLEEIMKRTRRTEATDK 618
EE +R R+ RE+ + ++Q+RL R+++L + RR + ++
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 619 KTSDQR 624
+ +R
Sbjct: 322 REQQER 327
Score = 68.2 bits (165), Expect = 3e-11
Identities = 56/164 (34%), Positives = 87/164 (53%), Gaps = 17/164 (10%)
Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQ----------RVAEERTTRR 527
E +L + K E ++E+ RRE EL R+ REE Q + EE+ R+
Sbjct: 189 EEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Query: 528 EEESRRLEAEQAREKEEQLQR--QAEERALREREEAE-RAQRQKEEEARV---REEAERV 581
E R E E+ +E+E Q QR Q EE LR+ E E R +RQ+EE+ + RE+ R
Sbjct: 249 RETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRR 308
Query: 582 RQEREKHFQREE-QERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+QE E+ Q+EE +E+ ER+++ EE ++ R E +++ R
Sbjct: 309 KQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Score = 68.2 bits (165), Expect = 3e-11
Identities = 46/150 (30%), Positives = 84/150 (56%), Gaps = 23/150 (15%)
Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTR-----------REEESRRL 534
+RR + Q ++EER R+Q+E E Q+R+ Q AEE++ R RE+ R+L
Sbjct: 740 RRRESELQWQEEERAHRQQQE-EEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQL 798
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQR----QKEEEARVREEAERVRQEREKHFQ 590
AE+ +++E++ + EE+ R R+ ER + ++EE+ + RE A+++++E + +
Sbjct: 799 RAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE 858
Query: 591 REEQERLERKKR-------LEEIMKRTRRT 613
+E+ R + ++R LEE KR R T
Sbjct: 859 DQERRRSQEQRRDQKWRWQLEEERKRRRHT 888
Score = 68.2 bits (165), Expect = 3e-11
Identities = 49/163 (30%), Positives = 87/163 (53%), Gaps = 27/163 (16%)
Query: 477 EEATRLLAEKRRLAREQREKEERERR------------EQEELERQKR------EELAQR 518
E + L E+++L R++R+++ RE+ E+++L RQ+R EE R
Sbjct: 1482 ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLR 1541
Query: 519 VAEERTTRREEESRRL-EAEQAREK--EEQLQRQAEERALR------EREEAERAQRQKE 569
E RR++ R+ E EQ R++ E+QL RQ +R R R+E ER + E
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE 1601
Query: 570 EEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRR 612
++ R +E +++RQER++ F+ +EQ ER+++ +R R+
Sbjct: 1602 QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644
Score = 67.8 bits (164), Expect = 4e-11
Identities = 48/139 (34%), Positives = 78/139 (56%), Gaps = 15/139 (10%)
Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTR--REEESRR-----LEA 536
A + ++ R++E + RR+++E +R++RE Q EER R +EEE RR +A
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773
Query: 537 EQAREKEEQL------QRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
E+ E+ Q R+ ER LR E +R QR EE +E+ R R+EREK Q
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE-KEQRRRQRREREKELQ 832
Query: 591 -REEQERLERKKRLEEIMK 608
EE+E+L+R++R +++ +
Sbjct: 833 FLEEEEQLQRRERAQQLQE 851
Score = 67.8 bits (164), Expect = 4e-11
Identities = 56/179 (31%), Positives = 96/179 (53%), Gaps = 41/179 (22%)
Query: 477 EEATRLLAEKRRLAREQREK-----------EERERREQEELERQKREELAQRVAEERTT 525
EE R E+++L+R++R++ +E+ER+ E+ ++ +R+E Q++ +ER
Sbjct: 1560 EEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDR 1619
Query: 526 R-REEESRRLEAEQAR-----------EKEEQLQRQAEERALRE------REEAERAQ-- 565
+ RE+E E E+ + E+E QL+RQ E+ LR REE + Q
Sbjct: 1620 KFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEG 1679
Query: 566 -----RQKEEEARVREEAERV-RQEREKHFQREEQ----ERLERKKRLEEIMKRTRRTE 614
R++E + + REE +++ RQERE+ F +EEQ + LERK R EE +++ E
Sbjct: 1680 EEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQE 1738
Score = 67.4 bits (163), Expect = 5e-11
Identities = 50/180 (27%), Positives = 89/180 (49%), Gaps = 40/180 (22%)
Query: 485 EKRRLAREQREKE----ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQ-- 538
++RR R+++E+E E + +QE LE++ R+ + + +R +E E RR E EQ
Sbjct: 135 QRRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 539 ---------------------------AREKEEQLQRQAEERALREREEAERAQRQ---- 567
RE+++Q +R+ ++R +E EE E +R+
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 568 KEEEARVREEAERVR--QEREKHFQREEQERLERKKRLEE-IMKRTRRTEATDKKTSDQR 624
KEEE EE +R R QE E+ ++ E++ L R+++ EE +R RR + +K ++R
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Score = 67.0 bits (162), Expect = 6e-11
Identities = 50/169 (29%), Positives = 92/169 (54%), Gaps = 30/169 (17%)
Query: 485 EKRRLAREQREKEE---RERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQARE 541
++RR R+++ +EE R+ RE+++L RQ+R+ R+ E++ R+E+E + +E EQ
Sbjct: 1547 QQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKF-RLEEQKVRRQEQERKFMEDEQQLR 1605
Query: 542 KEEQLQRQAEER---------ALREREE-----AERAQRQKEEEARVR--EEAERVRQER 585
++E Q+ +ER L+EREE ER ++ EEE ++R E +++R +R
Sbjct: 1606 RQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDR 1665
Query: 586 EKHFQREEQ----------ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
++ F+ EEQ R ER ++ E ++ RR E K +++
Sbjct: 1666 DRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQ 1714
Score = 65.5 bits (158), Expect = 2e-10
Identities = 40/130 (30%), Positives = 71/130 (54%), Gaps = 5/130 (3%)
Query: 495 EKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERA 554
E++ER+R E ER++ ++ + EE REE+ ++ ++E+QL R+ E
Sbjct: 1273 EQQERDR----EQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEK 1328
Query: 555 LREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
R R+E +R R++E+ + REE RQER++ F+ EE E+ ++ E +R RR E
Sbjct: 1329 -RRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQE 1387
Query: 615 ATDKKTSDQR 624
K +++
Sbjct: 1388 RERKFLKEEQ 1397
Score = 65.1 bits (157), Expect = 2e-10
Identities = 48/166 (28%), Positives = 91/166 (54%), Gaps = 25/166 (15%)
Query: 477 EEATRLLAEKRRLAREQRE----KEERERREQEELERQKREELAQRVAEERTTRREEESR 532
+E R E+ +L +E+ E ++ER+R+ EE ++ +R+E ++ E+ +E E +
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERK 1516
Query: 533 RLEAEQAR----------EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR 582
LE EQ ++E+QL+RQ ER + R++ +R R++E+ + REE + R
Sbjct: 1517 FLEEEQQLHRQQRQRKFLQEEQQLRRQ--ERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574
Query: 583 QEREKHFQ-------REEQER--LERKKRLEEIMKRTRRTEATDKK 619
QER++ F+ R+EQER +E +++L + + + D+K
Sbjct: 1575 QERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Score = 64.7 bits (156), Expect = 3e-10
Identities = 47/166 (28%), Positives = 86/166 (51%), Gaps = 22/166 (13%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQE--ELERQKREELAQRVAEERTTRREEESRRL 534
EE E+ R RE+ ++ R+ RE++ E E+Q R+E ++ EE +E E ++L
Sbjct: 1419 EEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQL 1478
Query: 535 EAEQAR----EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
++ E+E+QL+RQ +R RE+E + Q+ E + EE + RQ+R++ F
Sbjct: 1479 HRQERDRKFLEEEQQLRRQERDRKFREQE----LRSQEPERKFLEEEQQLHRQQRQRKFL 1534
Query: 591 REEQ------------ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+EEQ + +RK R EE +++ R + ++ D++
Sbjct: 1535 QEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRK 1580
Score = 64.3 bits (155), Expect = 4e-10
Identities = 52/157 (33%), Positives = 79/157 (50%), Gaps = 22/157 (14%)
Query: 483 LAEKRRLAREQREKEERERREQEE---LERQKREELAQRVAEERTTRREEESRRLEAEQA 539
L + RR +QR E R+R+ +EE RQKR+E + +AE + E+ RLE
Sbjct: 109 LLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGE--EQSEKQERLEQRDR 166
Query: 540 REKEEQLQRQAEERALREREEAERAQRQK-----------EEEARVREEAERVRQEREKH 588
+ ++E+L RQ +E RE AE Q Q EE+ R RE E R+ RE+
Sbjct: 167 QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE- 225
Query: 589 FQREEQERLERKKRL--EEIMKRTRRTEATDKKTSDQ 623
++Q+R ER+ R+ EE K R+ E +K ++
Sbjct: 226 ---KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Score = 64.3 bits (155), Expect = 4e-10
Identities = 54/190 (28%), Positives = 90/190 (47%), Gaps = 42/190 (22%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQE---ELERQKREELAQRVAE------------ 521
E+ + E+ RL + + + E ERREQE E + Q RE + R+ +
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR 715
Query: 522 -----ERTTRREEESRRLEAEQAREKEE-QLQRQAEERALREREEAERAQ--------RQ 567
R ++E + RR E E+ R + E +LQ Q EERA R+++E E+ + +
Sbjct: 716 QSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEE 775
Query: 568 KEEEAR--------VREEAERV-----RQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
K E R +RE+ ER RQ+RE+ F EE+E+ +R+++ E K + E
Sbjct: 776 KSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLE 835
Query: 615 ATDKKTSDQR 624
++ +R
Sbjct: 836 EEEQLQRRER 845
Score = 62.0 bits (149), Expect = 2e-09
Identities = 35/99 (35%), Positives = 61/99 (61%), Gaps = 4/99 (4%)
Query: 61 LRVDDRQRLARERREEREKQLAAREIVWLER--EERARQHYEKHLEERKKRLEEQRQKEE 118
LR +RQ L RER+EE ++Q R L R EE R+ E+ E++++R +++ ++E+
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 119 RRRAAVEEKRRQRL--EEDKERHEAVVRRTMERSQKPKQ 155
+ R EE+R Q+L E+++ER E +RR E ++ +Q
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQ 376
Score = 58.9 bits (141), Expect = 2e-08
Identities = 44/115 (38%), Positives = 64/115 (55%), Gaps = 8/115 (6%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQK---REELAQRVAEERTTRREEESRR 533
EE R E+++L +QR+ + R EQ +LE Q+ R+E ++ E +E+SRR
Sbjct: 1800 EEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRR 1859
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKH 588
E E +E EEQ +RQ ER LRE E +RQ++EE R R+ E QE + H
Sbjct: 1860 EEQELWQE-EEQKRRQERERKLRE----EHIRRQQKEEQRHRQVGEIKSQEGKGH 1909
Score = 57.4 bits (137), Expect = 5e-08
Identities = 37/98 (37%), Positives = 60/98 (61%), Gaps = 8/98 (8%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHY--EKHLEERKKRLEEQRQKEERR--- 120
+QRL RE+ E E++L E+ LE+EER Q E+ EER+++L + ++EERR
Sbjct: 587 QQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQ 646
Query: 121 -RAAVEEKRRQRL--EEDKERHEAVVRRTMERSQKPKQ 155
R +E+R QRL EE++ER E ++R E ++ ++
Sbjct: 647 LRREQQERREQRLKREEEEERLEQRLKREHEEERREQE 684
Score = 55.8 bits (133), Expect = 1e-07
Identities = 47/153 (30%), Positives = 77/153 (50%), Gaps = 16/153 (10%)
Query: 478 EATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESR 532
+AT L EKR + + Q ++E ++R E +RQ EE QR R R+E+E
Sbjct: 91 QATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQR---RRQKRQEQERE 147
Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
E E+ EK+E+L+++ +R R+E QRQ+ +E R E Q + H E
Sbjct: 148 LAEGEEQSEKQERLEQRDRQR----RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEE 203
Query: 593 --EQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
++E+L R++ LE ++R R E ++ Q
Sbjct: 204 FPDEEQLRRRELLE--LRRKGREEKQQQRRERQ 234
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/112 (36%), Positives = 66/112 (58%), Gaps = 15/112 (13%)
Query: 60 VLRVDDRQRLARERREER-EKQLAAREIVWLEREERARQH-----YEKHLEERKKRLEEQ 113
+L+ ++ +RL +ERRE+R +++ R L+REE RQ E+ LE+R KR E +
Sbjct: 549 LLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVE 608
Query: 114 R-QKEERR-----RAAVEEKRRQRL---EEDKERHEAVVRRTMERSQKPKQK 156
R ++EERR R EE+RRQ+L EE +ER + +RR + ++ + K
Sbjct: 609 RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLK 660
Score = 54.7 bits (130), Expect = 3e-07
Identities = 33/104 (31%), Positives = 59/104 (56%), Gaps = 4/104 (3%)
Query: 60 VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ--RQKE 117
VLR ++ + E + +RE Q ++ LER+E R+ E+ ++++ R E+Q R++E
Sbjct: 252 VLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQE 311
Query: 118 ERRRAAVEEKRRQ--RLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E RR EE+R Q R E+ +ER E +RR E ++ + + +
Sbjct: 312 EERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQ 355
Score = 52.8 bits (125), Expect = 1e-06
Identities = 28/96 (29%), Positives = 53/96 (55%), Gaps = 2/96 (2%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
Q+L RE++ RE+QL + + E++ R Q + EE + + ++++ E+R +E
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 127 KRRQRL--EEDKERHEAVVRRTMERSQKPKQKHNRW 160
+RR L EE+ ERHE R+ + + +++ RW
Sbjct: 453 ERRDWLKREEETERHEQERRKQQLKRDQEEERRERW 488
Score = 51.6 bits (122), Expect = 3e-06
Identities = 36/116 (31%), Positives = 59/116 (50%), Gaps = 7/116 (6%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
Q+ +ERRE+R K+ WL+REE E+H +ER+K+ ++ Q+EERR ++
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEET----ERHEQERRKQQLKRDQEEERRERWLKL 491
Query: 127 KRRQRLEEDKERHEAVVRRTME--RSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
+ +R E +ER E +RR E R Q+ K++ L + +RR
Sbjct: 492 EEEER-REQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546
Score = 51.6 bits (122), Expect = 3e-06
Identities = 28/101 (27%), Positives = 58/101 (57%), Gaps = 14/101 (13%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
+Q+L R++ EER ++ WL+ EE R+ ++ E++ +R +E+R+++ +R E
Sbjct: 473 KQQLKRDQEEERRER-------WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 126 EKRRQRL-------EEDKERHEAVVRRTMERSQKPKQKHNR 159
E+ +QRL E +ER E +++R E+ + +++ R
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQR 566
Score = 50.4 bits (119), Expect = 6e-06
Identities = 31/95 (32%), Positives = 54/95 (56%), Gaps = 11/95 (11%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERRR 121
++ + L RE RE+R +Q R+ REE Q E+ L EER+KR ++R+++ R+
Sbjct: 908 EEEEELQREEREKRRRQEQERQY----REEEQLQQEEEQLLREEREKRRRQERERQYRKD 963
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+++K Q L E+ E+ RR ER +K +++
Sbjct: 964 KKLQQKEEQLLGEEPEK-----RRRQEREKKYREE 993
Score = 50.1 bits (118), Expect = 8e-06
Identities = 29/86 (33%), Positives = 55/86 (63%), Gaps = 3/86 (3%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREER-ARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
+QRL RE++ R+++ RE RE++ R+ E+ E++ +R +E+R++++ RR
Sbjct: 297 QQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQE 356
Query: 125 EEKRRQRL--EEDKERHEAVVRRTME 148
EE+R Q+L E+++ER E +RR +
Sbjct: 357 EERREQQLRREQEEERREQQLRREQQ 382
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/97 (34%), Positives = 54/97 (55%), Gaps = 9/97 (9%)
Query: 67 QRLARER-REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
QRL RE EER +QL E R+++ R+ ++ E+R KR EE+ + E+R + E
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
E+RR++ ++E+ +A R +S+ PK W W
Sbjct: 678 EERREQELAEEEQEQA---RERIKSRIPK-----WQW 706
Score = 49.7 bits (117), Expect = 1e-05
Identities = 33/105 (31%), Positives = 55/105 (52%), Gaps = 16/105 (15%)
Query: 58 PPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKE 117
PP+ +RQ A ER++ ++ L E E+E+R RQ E+ E+ + LEE+ Q +
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEE----EKEQRRRQRRER--EKELQFLEEEEQLQ 841
Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
R RA ++ L+ED+ER RR+ E +++ +W W
Sbjct: 842 RRERAQQLQEEEDGLQEDQER-----RRSQE-----QRRDQKWRW 876
Score = 49.7 bits (117), Expect = 1e-05
Identities = 34/102 (33%), Positives = 55/102 (53%), Gaps = 9/102 (8%)
Query: 64 DDRQRLARER--REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
+ R+R RER REE E Q +++ ERE+R RQ E+ E + E Q+++E+ R
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE---EVQQEEEQLLR 1155
Query: 122 AAVEEKRRQRLE----EDKERHEAVVRRTMERSQKPKQKHNR 159
E++RRQ LE E++E + + E +K +Q+ R
Sbjct: 1156 EEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERER 1197
Score = 49.7 bits (117), Expect = 1e-05
Identities = 30/99 (30%), Positives = 54/99 (54%), Gaps = 6/99 (6%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ-----KEERR 120
RQ R+ REE E Q +++ ERE+R RQ E+ E ++ +E+ Q E+RR
Sbjct: 1103 RQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRR 1162
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R +E + R+ EE ++ E ++R E+ ++ +++ R
Sbjct: 1163 RQELERQYREE-EELQQEEEQLLREEQEKRRQERERQYR 1200
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/105 (31%), Positives = 56/105 (53%), Gaps = 6/105 (5%)
Query: 61 LRVDDRQRLARERREEREKQL-AAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEE 118
LR R+ ++RRE +++ E W +RE R+ EK EE +R E Q ++E+
Sbjct: 218 LRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQ 277
Query: 119 RRRAAVEEKRRQRLEEDKE----RHEAVVRRTMERSQKPKQKHNR 159
R+ +E RR+R EE+++ R E +RR E ++ +Q+ R
Sbjct: 278 LRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322
Score = 49.3 bits (116), Expect = 1e-05
Identities = 27/97 (27%), Positives = 55/97 (56%), Gaps = 2/97 (2%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE-RRRAAVE 125
Q+L RE+ EER +Q RE L RE++ R+ + E++ +R ++ R++++ RR +
Sbjct: 362 QQLRREQEEERREQQLRRE-QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 420
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
+++ R E+++ERHE + + +++ R W
Sbjct: 421 REQQLRREQEEERHEQKHEQERREQRLKREQEERRDW 457
Score = 48.9 bits (115), Expect = 2e-05
Identities = 32/97 (32%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 66 RQRLARERREER---EKQLAAREIVWLEREE----RARQHYEKHLEERKKRLEEQRQKEE 118
RQR +E E+ E+Q RE E+++ R +Q K EER+++ EE+R+++E
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
RR E + +Q E +ER E +RR E ++ +Q
Sbjct: 327 RREQQEERREQQLRREQEERREQQLRREQEEERREQQ 363
Score = 48.9 bits (115), Expect = 2e-05
Identities = 31/99 (31%), Positives = 55/99 (55%), Gaps = 8/99 (8%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R + +R R +R+E E++L R L E++ R+ E+ E+ KR EE+R ++ERR
Sbjct: 509 REQEERREQRLKRQEEEERLQQR----LRSEQQLRREQEERREQLLKREEEKRLEQERRE 564
Query: 122 AAV----EEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ EE+R Q L+ ++ER + ++R E + + K
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLK 603
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/80 (35%), Positives = 50/80 (62%), Gaps = 2/80 (2%)
Query: 71 RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR-LEEQRQKEERRRAAVEEKRR 129
RE++EER +Q RE RE++ R+ E+ E++ +R EE+R++++ RR EE+R
Sbjct: 315 REQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERRE 374
Query: 130 QRLEEDKE-RHEAVVRRTME 148
Q+L +++ R E +RR +
Sbjct: 375 QQLRREQQLRREQQLRREQQ 394
Score = 48.5 bits (114), Expect = 2e-05
Identities = 28/93 (30%), Positives = 52/93 (55%), Gaps = 1/93 (1%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
Q+L RE+ EER +Q RE RE++ R+ + E++ +R ++ R++++ RR
Sbjct: 349 QQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLR 408
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ +Q E + R E +RR E ++ +QKH +
Sbjct: 409 REQQLRREQQLRREQQLRREQE-EERHEQKHEQ 440
Score = 48.5 bits (114), Expect = 2e-05
Identities = 31/89 (34%), Positives = 50/89 (56%), Gaps = 8/89 (8%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHY--EKHLEERKKRLEEQRQKEERRRAAV 124
Q+L RE+ E RE++L +E EER +Q E+ L ++ EQ K E +
Sbjct: 505 QQLRREQEERREQRLKRQE-----EEERLQQRLRSEQQLRREQEERREQLLKREEEKRLE 559
Query: 125 EEKRRQRLE-EDKERHEAVVRRTMERSQK 152
+E+R QRL+ E +ER + +++R ER Q+
Sbjct: 560 QERREQRLKREQEERRDQLLKREEERRQQ 588
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/100 (31%), Positives = 56/100 (56%), Gaps = 11/100 (11%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV-- 124
Q+L RE+ EER +Q +E RE+R ++ E+ + K+ E +R ++ERR+ +
Sbjct: 423 QQLRREQEEERHEQKHEQE----RREQRLKREQEERRDWLKREEETERHEQERRKQQLKR 478
Query: 125 --EEKRRQR---LEEDKERHEAVVRRTMERSQKPKQKHNR 159
EE+RR+R LEE++ R + R R ++ +++ R
Sbjct: 479 DQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518
Score = 48.1 bits (113), Expect = 3e-05
Identities = 31/100 (31%), Positives = 54/100 (54%), Gaps = 9/100 (9%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLE---REERARQHYEKHLEERKKRLEEQRQ--- 115
R+ Q+L RE+ E RE+ L E LE RE+R ++ E+ ++ KR EE+RQ
Sbjct: 531 RLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRL 590
Query: 116 ---KEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
+EER ++ + +RLE+++ R + + R E ++
Sbjct: 591 KREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERR 630
Score = 47.8 bits (112), Expect = 4e-05
Identities = 28/94 (29%), Positives = 50/94 (53%), Gaps = 2/94 (2%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
R L RE ER +Q ++ + ++EE R+ + K EE ++ +E+R+++ RR E
Sbjct: 455 RDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ--E 512
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E+R QRL+ +E R E+ + +Q+ R
Sbjct: 513 ERREQRLKRQEEEERLQQRLRSEQQLRREQEERR 546
Score = 47.8 bits (112), Expect = 4e-05
Identities = 33/102 (32%), Positives = 54/102 (52%), Gaps = 9/102 (8%)
Query: 64 DDRQRLARERREEREKQLAARE--IVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
+ R+R +ER+ E+QL E ++ ERE+R RQ E+ + KK +QKEE+
Sbjct: 919 EKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKK----LQQKEEQLL 974
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTME---RSQKPKQKHNRW 160
EKRR++ E K R E +++ E R ++ K++ W
Sbjct: 975 GEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Score = 47.8 bits (112), Expect = 4e-05
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 11/109 (10%)
Query: 65 DRQRLARERREER-----EKQLAAREIVWLEREERARQHYEK----HLEERKKRLEEQRQ 115
+ ++L RE RE+R E+Q E V E E+ R+ EK LE + + EE +Q
Sbjct: 1119 EEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178
Query: 116 KEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHN--RWSW 162
+EE+ +EKRRQ E E + R+ ++ + + + + +W W
Sbjct: 1179 EEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Score = 47.4 bits (111), Expect = 5e-05
Identities = 30/98 (30%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ----KEERRR 121
RQ R+ REE + Q +++ ERE+R RQ E+ + KK +++ Q + E+RR
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
EK+ + EE ++ E ++R ER ++ +Q+ R
Sbjct: 983 RQEREKKYREEEELQQEEEQLLRE--EREKRRRQEWER 1018
Score = 47.0 bits (110), Expect = 6e-05
Identities = 31/105 (29%), Positives = 57/105 (54%), Gaps = 11/105 (10%)
Query: 66 RQRLARERREEREKQLAAREIVW------LEREERARQHYEKHLEERKKRLEEQ-----R 114
R+R R +EE EK+ RE V L+ EE RQ + EE+ ++LE Q R
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
Q+EE+++ + +++ R ++++ER E R ++ ++ +Q+ R
Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Score = 46.6 bits (109), Expect = 8e-05
Identities = 29/94 (30%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
RQ L R+ R+E E Q +++ E E+R RQ E+ E + E Q+++E+ R E
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE---ELQQEEEQLLREERE 1129
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
++RRQ LE E V + + ++ +K R
Sbjct: 1130 KRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Score = 46.6 bits (109), Expect = 8e-05
Identities = 34/99 (34%), Positives = 52/99 (52%), Gaps = 3/99 (3%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLER--EERARQHYEKHLEERKKRLEEQRQKEERRR 121
+++Q L ER E+R +Q R+ E+ +ER Q + +RK R EE R +E+ R+
Sbjct: 1316 EEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK 1375
Query: 122 AAVEEKRRQRLE-EDKERHEAVVRRTMERSQKPKQKHNR 159
EE+R +R E E K E R ER Q+ +Q +R
Sbjct: 1376 FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDR 1414
Score = 46.2 bits (108), Expect = 1e-04
Identities = 33/100 (33%), Positives = 50/100 (50%), Gaps = 10/100 (10%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQ--------RQK 116
Q R+ REE E Q +++ ERE R RQ E+ EE ++ EEQ R++
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103
Query: 117 EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ER R EE+ Q+ EE R E RR E ++ +++
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREE 1143
Score = 45.8 bits (107), Expect = 1e-04
Identities = 29/98 (29%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ----RQKEERRR 121
RQ ++ REE E Q +++ ERE+R RQ +E+ ++ + +E+ R++ E+RR
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
++E+ RQ EE++ + E ER + +Q+ R
Sbjct: 1043 --LQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078
Score = 45.8 bits (107), Expect = 1e-04
Identities = 40/129 (31%), Positives = 64/129 (49%), Gaps = 30/129 (23%)
Query: 64 DDRQRLARERREER----EKQLAAREIVWLEREE------------RARQHYEKHLEE-- 105
++ Q+L R+ RE + E+QL +E+ REE R ++ Y K LEE
Sbjct: 1695 EEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQ 1754
Query: 106 -RKKRLEEQRQKEER-RRAAVEEKRRQRLEED---------KERHEAVVRRTMERSQ-KP 153
R +R E+Q +++ER R+ EE+ RQ EE K R E +R+ E Q +P
Sbjct: 1755 LRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814
Query: 154 KQKHNRWSW 162
+Q+ ++ W
Sbjct: 1815 QQRDGKYRW 1823
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/85 (31%), Positives = 46/85 (54%), Gaps = 1/85 (1%)
Query: 65 DRQRLARERREEREKQLAARE-IVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
++Q RE++E RE+Q RE + E+EER Q + EE ++ + +R++EE RR
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 124 VEEKRRQRLEEDKERHEAVVRRTME 148
+ +Q E + R E +RR +
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQ 400
Score = 45.4 bits (106), Expect = 2e-04
Identities = 27/102 (26%), Positives = 56/102 (54%), Gaps = 8/102 (7%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
R++ R +EER +Q RE RE++ R+ E+ E++ R E+Q ++E++ R +
Sbjct: 335 REQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQ 394
Query: 126 EKRRQRLEEDKE-RHEAVVRRTME-------RSQKPKQKHNR 159
+R Q+L +++ R E +RR + R ++ +++H +
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQ 436
Score = 45.4 bits (106), Expect = 2e-04
Identities = 30/97 (30%), Positives = 55/97 (56%), Gaps = 5/97 (5%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQH-YEKHLEERKKRL----EEQRQKEER 119
+RQ E+ ++ E+QL E R+ER RQ+ +K L++++++L E+R+++ER
Sbjct: 927 ERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER 986
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ EE+ Q+ EE R E RR E ++ ++K
Sbjct: 987 EKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023
Score = 45.4 bits (106), Expect = 2e-04
Identities = 25/102 (24%), Positives = 55/102 (53%), Gaps = 9/102 (8%)
Query: 55 PDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQR 114
P+ + R + ++ R+R+ + EKQL E E+R RQ ++ E ++ L+E+
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREE----REEKRRRQETDRKFREEEQLLQERE 1349
Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
++ RR ++R ++ E++ RH+ R+ +E Q+ +++
Sbjct: 1350 EQPLRR-----QERDRKFREEELRHQEQGRKFLEEEQRLRRQ 1386
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/94 (30%), Positives = 51/94 (54%), Gaps = 3/94 (3%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
R+R + EER +Q RE L RE+ R+ +E ++RL+++ + E++ R E
Sbjct: 485 RERWLKLEEEERREQQERRE-QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQE 543
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E+R Q L+ ++E+ RR E+ K +Q+ R
Sbjct: 544 ERREQLLKREEEKRLEQERR--EQRLKREQEERR 575
Score = 45.1 bits (105), Expect = 2e-04
Identities = 30/96 (31%), Positives = 58/96 (60%), Gaps = 7/96 (7%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
+QRL E++ RE++ ++ L+REE R E+ E+R KR +E+R+ + +R E
Sbjct: 529 QQRLRSEQQLRREQEERREQL--LKREEEKRLEQERR-EQRLKREQEERRDQLLKRE--E 583
Query: 126 EKRRQRLEEDKER--HEAVVRRTMERSQKPKQKHNR 159
E+R+QRL+ ++E + + R +ER ++ +++ R
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQR 619
Score = 45.1 bits (105), Expect = 2e-04
Identities = 31/99 (31%), Positives = 57/99 (57%), Gaps = 8/99 (8%)
Query: 63 VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ--RQKEERR 120
+++ Q+L R++R+ + Q E L R+ER +Q + +RK R EEQ +++EE++
Sbjct: 1518 LEEEQQLHRQQRQRKFLQ----EEQQLRRQERGQQRRQDR--DRKFREEEQLRQEREEQQ 1571
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ E R+ RLEE K R + R+ ME Q+ +++ +
Sbjct: 1572 LSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQ 1610
Score = 44.7 bits (104), Expect = 3e-04
Identities = 30/95 (31%), Positives = 51/95 (53%), Gaps = 4/95 (4%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE--RRR 121
+ ++RL + R+ R+++L + W EREER + E+ L+ K E+ EE RRR
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAE--EEQLQSCKGHETEEFPDEEQLRRR 213
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E +R+ R E+ ++R E R E +K +K
Sbjct: 214 ELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRK 248
Score = 44.3 bits (103), Expect = 4e-04
Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 20/109 (18%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ------------- 113
QRL RE EER +Q A E +E+AR+ + + + + +LE +
Sbjct: 670 QRLKREHEEERREQELAEE-----EQEQARERIKSRIPKWQWQLESEADARQSKVYSRPR 724
Query: 114 RQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
+Q+ +RRR EEKRR+R E + + E R ++ ++ +++ W W
Sbjct: 725 KQEGQRRRQEQEEKRRRRESELQWQEEERAHR--QQQEEEQRRDFTWQW 771
Score = 43.9 bits (102), Expect = 5e-04
Identities = 28/110 (25%), Positives = 56/110 (50%), Gaps = 17/110 (15%)
Query: 64 DDRQRLARERREEREKQLAARE--IVWLEREERARQHYEKHL---------------EER 106
+ R+R RER+ ++K+L +E ++ E E+R RQ EK EER
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREER 1008
Query: 107 KKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+KR ++ +++ R++ ++++ Q L E++E+ R R ++ Q+
Sbjct: 1009 EKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQ 1058
Score = 43.5 bits (101), Expect = 7e-04
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 5/91 (5%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
R+ + RR+ERE+Q E + E E+ R+ EK ++R E +RQ E E
Sbjct: 1095 REEPEKRRRQERERQCREEEELQQEEEQLLREEREK-----RRRQELERQYREEEEVQQE 1149
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
E++ R E +K R + + R+ E + +++
Sbjct: 1150 EEQLLREEPEKRRRQELERQYREEEELQQEE 1180
Score = 43.1 bits (100), Expect = 0.001
Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 4/100 (4%)
Query: 64 DDRQRLARERREEREKQLAARE--IVWLEREERARQHYEKHL--EERKKRLEEQRQKEER 119
+ R+ RER+ E++L E ++ ERE R RQ E+ EE ++ EEQ +EE
Sbjct: 1039 EKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP 1098
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ +E+ RQ EE++ + E ER ++ +Q+ R
Sbjct: 1099 EKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138
Score = 43.1 bits (100), Expect = 0.001
Identities = 30/103 (29%), Positives = 56/103 (54%), Gaps = 14/103 (13%)
Query: 64 DDRQRLARERR------EEREKQLAAREIVWLEREERARQHYEKHLEER----KKRLEEQ 113
++ Q+L+R+ R EE++ + RE +LE E++ RQ + E ++R E+Q
Sbjct: 1418 EEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477
Query: 114 RQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
++ER R +EE+++ R +E + R RSQ+P++K
Sbjct: 1478 LHRQERDRKFLEEEQQLRRQE----RDRKFREQELRSQEPERK 1516
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/96 (27%), Positives = 53/96 (55%), Gaps = 5/96 (5%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ--RQKEERRRAA 123
RQ ++RR++R+++ E + R+ER Q + +RK RLEEQ R++E+ R+
Sbjct: 1542 RQERGQQRRQDRDRKFREEEQL---RQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+E++ +R E ++ + R+ E Q +++ +
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQ 1634
Score = 43.1 bits (100), Expect = 0.001
Identities = 39/107 (36%), Positives = 61/107 (57%), Gaps = 13/107 (12%)
Query: 65 DRQRLARE---RREEREKQLAA-REIVWLEREERARQHYEKHLE----ERKKRLEEQR-Q 115
DR+ L E RR+ERE+QL R+ + E E+ ++ E+ L +RK R EEQ+ +
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701
Query: 116 KEERRRAAVEEK---RRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
++ER R ++E+ RRQ LE K R E +R+ E+ Q +Q+ R
Sbjct: 1702 RQERERKFLQEEQQLRRQELER-KFREEEQLRQETEQEQLRRQERYR 1747
Score = 42.7 bits (99), Expect = 0.001
Identities = 23/92 (25%), Positives = 54/92 (58%), Gaps = 5/92 (5%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
+ ++L RE RE+R +Q R+ + +++E ++ + EER+KR ++R+++ R +
Sbjct: 999 EEEQLLREEREKRRRQEWERQ--YRKKDELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+++ Q L E++E R+ +ER + +++
Sbjct: 1057 QQEEEQLLGEERETRR---RQELERQYRKEEE 1085
Score = 42.7 bits (99), Expect = 0.001
Identities = 26/103 (25%), Positives = 51/103 (49%), Gaps = 7/103 (6%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
+QR + R EE + QL E+E+R RQ ++ ++ +++ + E + E
Sbjct: 1815 QQRDGKYRWEEEQLQLE-------EQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHG 168
E++++R E +++ E +RR + Q+ +Q S G HG
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHG 1910
Score = 42.4 bits (98), Expect = 0.002
Identities = 29/99 (29%), Positives = 52/99 (52%), Gaps = 5/99 (5%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKH-LEERKK--RLEEQRQKEERRRA 122
R+ + RR+E E+Q ++ + E E+ R+ EK L+ER++ R EE+ Q+EE +
Sbjct: 1005 REEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLL 1064
Query: 123 AVEE--KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E +RRQ LE + E + + + ++ +K R
Sbjct: 1065 GEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103
Score = 42.4 bits (98), Expect = 0.002
Identities = 30/104 (28%), Positives = 54/104 (51%), Gaps = 3/104 (2%)
Query: 56 DPPPVLRVDDRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEE 112
D + R + +Q+L +ER E E+ L RE L R+ER R+ E+ + R++ E+
Sbjct: 1600 DEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQ 1659
Query: 113 QRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
Q + + R+ EE+ Q EE + R + R+ E Q+ +++
Sbjct: 1660 QLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQ 1703
Score = 42.4 bits (98), Expect = 0.002
Identities = 35/114 (30%), Positives = 59/114 (51%), Gaps = 13/114 (11%)
Query: 59 PVLRVDDRQRLARERRE----EREKQLAAREIVWLEREERARQHYEKHLE------ERKK 108
P LR +R++ R R+ E E+ L E L R+ER R+ E+ + ERK
Sbjct: 1650 PQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKF 1709
Query: 109 RLEEQ--RQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ-KPKQKHNR 159
EEQ R++E R+ EE+ RQ E+++ R + R+ +E Q +P+++ +
Sbjct: 1710 LQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQ 1763
Score = 42.0 bits (97), Expect = 0.002
Identities = 28/120 (23%), Positives = 57/120 (47%), Gaps = 13/120 (10%)
Query: 515 LAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARV 574
L Q + R + + + R++E+Q + + +R L E R Q+++E+E +
Sbjct: 89 LGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQEREL 148
Query: 575 REEAERVRQEREKHFQREEQERLE---RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKG 631
E E Q E+QERLE R++R EE+ ++ + + +++ +++ KG
Sbjct: 149 AEGEE----------QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKG 198
Score = 42.0 bits (97), Expect = 0.002
Identities = 29/118 (24%), Positives = 53/118 (44%), Gaps = 21/118 (17%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
+Q L E +EER +Q RE + R+ E+ LE+R KR E+ ++E+ +
Sbjct: 631 QQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQ 690
Query: 126 EKRRQR-----------LEEDKERHEAVV----------RRTMERSQKPKQKHNRWSW 162
E+ R+R LE + + ++ V RR E+ +K +++ + W
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQW 748
Score = 42.0 bits (97), Expect = 0.002
Identities = 27/86 (31%), Positives = 49/86 (56%), Gaps = 7/86 (8%)
Query: 70 ARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRR 129
A + + +E+QL E L+REER ++ ++ +ER+ R EEQ Q+EE + E ++R
Sbjct: 894 ALQEQLRKEQQLLQEEEEELQREEREKRRRQE--QERQYREEEQLQQEEEQLLREEREKR 951
Query: 130 QRLEEDKERHEAVVRRTMERSQKPKQ 155
+R E +++ R+ + QK +Q
Sbjct: 952 RRQERERQ-----YRKDKKLQQKEEQ 972
Score = 41.6 bits (96), Expect = 0.003
Identities = 28/101 (27%), Positives = 48/101 (47%), Gaps = 8/101 (7%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHL--------EERKKRLEEQRQKE 117
RQ L R+ REE E Q +++ E E+R RQ E+ EE + EEQ ++
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHN 158
+ R E+ + ++ K+R+ +R+ + Q +K N
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233
Score = 41.6 bits (96), Expect = 0.003
Identities = 32/111 (28%), Positives = 62/111 (55%), Gaps = 11/111 (9%)
Query: 60 VLRVDDRQRLARERRE----EREKQLAA--REIVWLEREERARQHYEKHLEERKKRLEEQ 113
+L+ + Q+L R+ R+ E E+QL R+ + E+E R+++ K LEE ++ +Q
Sbjct: 1469 LLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQ 1528
Query: 114 RQK----EERRRAAVEEKRRQRLEEDKE-RHEAVVRRTMERSQKPKQKHNR 159
RQ+ EE++ E +++R + D++ R E +R+ E Q +Q+ +R
Sbjct: 1529 RQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDR 1579
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/123 (27%), Positives = 56/123 (45%), Gaps = 24/123 (19%)
Query: 61 LRVDDRQRLARE----RREEREKQLAAREI-VWLEREERARQHYEK-------------- 101
LR +R R RE R+E E+QL ++E EE+ RQ E+
Sbjct: 1764 LRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRW 1823
Query: 102 -----HLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
LEE+++RL ++R ++ R + + R EE + E +R ER +K +++
Sbjct: 1824 EEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREE 1883
Query: 157 HNR 159
H R
Sbjct: 1884 HIR 1886
Score = 41.2 bits (95), Expect = 0.004
Identities = 28/104 (26%), Positives = 52/104 (50%), Gaps = 10/104 (9%)
Query: 66 RQRLARERREEREKQLAAR--EIVWLEREERARQHYEKHLE-------ERKKRLEEQRQK 116
R++ + RR+E+E++ R E+ W E E RQ E+ + +++ E RQ+
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783
Query: 117 EERRRAAVEEKRRQ-RLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R E++ RQ R EE ++R + + E+ Q+ +Q+ R
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRER 827
Score = 41.2 bits (95), Expect = 0.004
Identities = 36/107 (33%), Positives = 62/107 (57%), Gaps = 15/107 (14%)
Query: 60 VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE------ERKKRLEEQ 113
+L+ + Q+L RR+ER+++ E L R+ER R+ ++ + ERK R EEQ
Sbjct: 1675 LLQEGEEQQL---RRQERDRKFREEE-QQLRRQERERKFLQEEQQLRRQELERKFREEEQ 1730
Query: 114 -RQKEERRRAAVEEKRRQRLEEDK---ERHEAVVRRTMERSQKPKQK 156
RQ+ E+ + +E+ R+ LEE++ ER E +RR ER +K +++
Sbjct: 1731 LRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR-QERDRKFREE 1776
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/95 (26%), Positives = 52/95 (54%), Gaps = 5/95 (5%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
+++D Q R+ +++ + L ++ E+E R Q ++H E +++LE + QKE +RR
Sbjct: 1252 QLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPE-EEQLEREEQKEAKRR 1310
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
++ +Q L E++E RR E +K +++
Sbjct: 1311 DRKSQEEKQLLREEREEK----RRRQETDRKFREE 1341
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/84 (25%), Positives = 44/84 (52%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
++Q ++ E RE+QL + E++ R Q E+ ++ ++ EE+R++++ RR
Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382
Query: 125 EEKRRQRLEEDKERHEAVVRRTME 148
+ +Q E + R E +RR +
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQ 406
Score = 40.4 bits (93), Expect = 0.006
Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 13/102 (12%)
Query: 71 RERREEREKQLAAREIVW---LEREERARQH-------YEKHLEERKKRL---EEQRQKE 117
+E +E R Q R+ W LE E + R+H ++ L + ++ L EE+ Q+E
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
ER + +E+ RQ EE++ + E ER ++ +Q+ R
Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER 958
Score = 40.4 bits (93), Expect = 0.006
Identities = 28/95 (29%), Positives = 51/95 (53%), Gaps = 4/95 (4%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
DR++ R R ++R++ E LEREE+ + +K+L + ++E+RRR
Sbjct: 1278 DREQ-ERRRWQQRDRHFPEEE--QLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQET 1334
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ K R+ + +ER E +RR ER +K +++ R
Sbjct: 1335 DRKFREEEQLLQEREEQPLRR-QERDRKFREEELR 1368
Score = 40.0 bits (92), Expect = 0.008
Identities = 28/97 (28%), Positives = 49/97 (50%), Gaps = 9/97 (9%)
Query: 71 RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
R++R+E+E++LA E E++ER Q + +E R ++ Q+ E RRA E+ +
Sbjct: 138 RQKRQEQERELAEGE-EQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC 196
Query: 131 RLEEDKE--------RHEAVVRRTMERSQKPKQKHNR 159
+ E +E R E + R R +K +Q+ R
Sbjct: 197 KGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRER 233
Score = 40.0 bits (92), Expect = 0.008
Identities = 24/89 (26%), Positives = 46/89 (51%), Gaps = 4/89 (4%)
Query: 72 ERREEREKQLAAREIVW--LEREERARQHYEKHL--EERKKRLEEQRQKEERRRAAVEEK 127
E R+ R L A+ + L +E++ Q E+ L EER+KR ++++++ R ++++
Sbjct: 880 EERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 128 RRQRLEEDKERHEAVVRRTMERSQKPKQK 156
Q L E++E+ R R K Q+
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQ 968
Score = 40.0 bits (92), Expect = 0.008
Identities = 24/66 (36%), Positives = 35/66 (53%), Gaps = 3/66 (4%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
DRQ A E+ +EK + +W E E++ RQ E+ L E R ++QKEE+R V
Sbjct: 1842 DRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIR---RQQKEEQRHRQV 1898
Query: 125 EEKRRQ 130
E + Q
Sbjct: 1899 GEIKSQ 1904
Score = 39.7 bits (91), Expect = 0.010
Identities = 28/115 (24%), Positives = 63/115 (54%), Gaps = 19/115 (16%)
Query: 64 DDRQRLARERREEREKQLA-AREIVWLEREERARQHYEKH---LEERKKRLEEQRQKEER 119
++ + R +R EREK+L E L+R ERA+Q E+ E++++R ++++++++
Sbjct: 814 EEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQK 873
Query: 120 RRAAVEEKRRQR---------LEEDKERHEAVVR------RTMERSQKPKQKHNR 159
R +EE+R++R L+E + + +++ + ER ++ +Q+ R
Sbjct: 874 WRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Score = 39.7 bits (91), Expect = 0.010
Identities = 27/97 (27%), Positives = 52/97 (53%), Gaps = 5/97 (5%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQH-YEKHLEERKKRL----EEQRQKEER 119
+RQ ++ ++ E+QL E +ER RQ+ E+ L++ +++L E R+++E
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
R +E+ Q+ EE R E RR ER ++ +++
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREE 1113
Score = 39.7 bits (91), Expect = 0.010
Identities = 30/109 (27%), Positives = 56/109 (51%), Gaps = 10/109 (9%)
Query: 61 LRVDDRQRLARER--REEREKQLAAREIVWLEREERAR----QHYEKHLEERKKRLEEQR 114
LR +R R RE R + + + E L R+ER R + + +ER+++L + R
Sbjct: 1353 LRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDR 1412
Query: 115 ----QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
++EE++ + E R+ R EE + R + R+ +E Q+ +Q+ +R
Sbjct: 1413 DRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHR 1461
Score = 39.7 bits (91), Expect = 0.010
Identities = 33/105 (31%), Positives = 54/105 (51%), Gaps = 8/105 (7%)
Query: 61 LRVDDRQRLARERRE----EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK 116
LR +R++ R+ R+ E E+QL+ +E REE Q + ERK EEQ+ +
Sbjct: 1399 LRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREE--EQQVRRQERERKFLEEEQQLR 1456
Query: 117 EERRRAAVEEKR--RQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ER R EE++ ++R E+ R E + E Q +Q+ +R
Sbjct: 1457 QERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDR 1501
Score = 39.3 bits (90), Expect = 0.014
Identities = 24/96 (25%), Positives = 51/96 (53%), Gaps = 3/96 (3%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
D+ Q RE E R K RE +R ER + +++ E+ ++ E +KEE +
Sbjct: 206 DEEQLRRRELLELRRK---GREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E +R++ L+E++E+ + R+ + R ++ +++ +
Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Score = 39.3 bits (90), Expect = 0.014
Identities = 26/101 (25%), Positives = 55/101 (54%), Gaps = 13/101 (12%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQR--QKEERRR 121
D + R + +ERE+Q R+ ER+ + R+ +H E+ +K LEE++ +++ER R
Sbjct: 1335 DRKFREEEQLLQEREEQPLRRQ----ERDRKFREEELRHQEQGRKFLEEEQRLRRQERER 1390
Query: 122 AAVEE-------KRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
++E +R Q+L +D++R + + R ++ ++
Sbjct: 1391 KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431
Score = 39.3 bits (90), Expect = 0.014
Identities = 33/112 (29%), Positives = 56/112 (50%), Gaps = 18/112 (16%)
Query: 63 VDDRQRLARERRE-------------EREKQLAAREIVWLEREERARQHYEKHLEERKKR 109
+++ QRL R+ RE ERE+QL EE+ E+ +RK R
Sbjct: 1377 LEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER---DRKFR 1433
Query: 110 LEEQR-QKEERRRAAVEEKRRQRLEEDKE-RHEAVVRRTMERSQKPKQKHNR 159
EEQ+ +++ER R +EE+++ R E ++ R E + + E Q +Q+ +R
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485
Score = 38.9 bits (89), Expect = 0.018
Identities = 22/95 (23%), Positives = 53/95 (55%), Gaps = 6/95 (6%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREER-ARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+ + + RR+ RE++ +E+ +LE EE+ R+ + L+E + L+E +++ +
Sbjct: 813 EEEEKEQRRRQRRERE---KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQR 869
Query: 124 VEEKRRQRLEEDKE--RHEAVVRRTMERSQKPKQK 156
++K R +LEE+++ RH + ++ + +Q+
Sbjct: 870 RDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQ 904
Score = 38.9 bits (89), Expect = 0.018
Identities = 24/91 (26%), Positives = 45/91 (49%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R D + R E +R + + E+ + +Q ++ EE ++ E+R+++E+ R
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQER 928
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
EE++ Q+ EE R E RR ER ++
Sbjct: 929 QYREEEQLQQEEEQLLREEREKRRRQERERQ 959
Score = 38.5 bits (88), Expect = 0.023
Identities = 28/101 (27%), Positives = 52/101 (51%), Gaps = 8/101 (7%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLERE-----ERARQHYEKHLEERKKRLEEQRQK 116
R D ++ L ++RR+E +++ LE E + RQ E+ L E +++ E+Q +
Sbjct: 102 RCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERL 161
Query: 117 EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKH 157
E+R R +E+ ++ +E +ER E RR E + + H
Sbjct: 162 EQRDRQRRDEELWRQRQEWQEREE---RRAEEEQLQSCKGH 199
Score = 37.4 bits (85), Expect = 0.051
Identities = 37/116 (31%), Positives = 55/116 (47%), Gaps = 28/116 (24%)
Query: 63 VDDRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
+++ Q+L +ER E E+ L RE L R+ER R K LEE E+Q +++ER
Sbjct: 1449 LEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR----KFLEE-----EQQLRRQER 1499
Query: 120 RRAAVE------EKRRQRLEEDKERH----------EAVVRRTMERSQKPKQKHNR 159
R E E R+ LEE+++ H E R ER Q+ +Q +R
Sbjct: 1500 DRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDR 1555
Score = 36.2 bits (82), Expect = 0.11
Identities = 24/89 (26%), Positives = 47/89 (52%), Gaps = 6/89 (6%)
Query: 73 RREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER---RRAAVEE--- 126
+R ER +QL E E +ER R ++ ++ + +LEE+R++ + A++E
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
K +Q L+E++E + R R ++ +Q
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQ 929
Score = 36.2 bits (82), Expect = 0.11
Identities = 23/90 (25%), Positives = 45/90 (50%), Gaps = 3/90 (3%)
Query: 63 VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
+ + Q+L R+ R ++ +Q R+ EE+ RQ E+ R++R + R +E++ R
Sbjct: 1534 LQEEQQLRRQERGQQRRQDRDRKF---REEEQLRQEREEQQLSRQERDRKFRLEEQKVRR 1590
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
+E++ E+ R E + ER +K
Sbjct: 1591 QEQERKFMEDEQQLRRQEGQQQLRQERDRK 1620
Score = 35.4 bits (80), Expect = 0.20
Identities = 33/111 (29%), Positives = 57/111 (51%), Gaps = 19/111 (17%)
Query: 65 DRQRLARERRE----EREKQLAAREIVWLEREERARQHYEKH--LEERKKRLEEQRQKEE 118
+ Q++ R+ +E E E+QL +E R+ER R+ E L+ER+ E+Q ++E
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQERE---EQQLHRQE 1640
Query: 119 RRRAAVEE-------KRRQRLEEDKE---RHEAVVRRTMERSQKPKQKHNR 159
R R +EE +R Q+L D++ R E + + E Q +Q+ +R
Sbjct: 1641 RDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Score = 35.0 bits (79), Expect = 0.25
Identities = 21/70 (30%), Positives = 42/70 (60%), Gaps = 2/70 (2%)
Query: 89 LEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE--KRRQRLEEDKERHEAVVRRT 146
L+ E+RAR ++ L + +++ E+QR+ E R R EE +RR++ +++ER A
Sbjct: 95 LDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQ 154
Query: 147 MERSQKPKQK 156
E+ ++ +Q+
Sbjct: 155 SEKQERLEQR 164
Score = 34.3 bits (77), Expect = 0.43
Identities = 28/120 (23%), Positives = 58/120 (48%), Gaps = 23/120 (19%)
Query: 62 RVDDRQRLARER--REER--------------------EKQLAAREIVWLEREERARQHY 99
R ++ R +E REER E+QL RE++ L R+ R +
Sbjct: 169 RDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQ 228
Query: 100 EKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
++ E + + +E+ +KE R+R V K ++L+E++ + + ++ E+ +K +++ R
Sbjct: 229 QRR-ERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELR 287
Score = 33.9 bits (76), Expect = 0.57
Identities = 25/79 (31%), Positives = 44/79 (55%), Gaps = 12/79 (15%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+ QRL R+ER++Q A E + +E+ R+ E EE +KR RQ+ ER+
Sbjct: 1832 EQEQRL----RQERDRQYRAEE-QFATQEKSRREEQELWQEEEQKR----RQERERK--- 1879
Query: 124 VEEKRRQRLEEDKERHEAV 142
+ E+ +R +++++RH V
Sbjct: 1880 LREEHIRRQQKEEQRHRQV 1898
Score = 30.8 bits (68), Expect = 4.8
Identities = 17/55 (30%), Positives = 29/55 (52%)
Query: 74 REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKR 128
REE+EK+ RE + E EE RQ ++ + +R + + Q E + AV + +
Sbjct: 1185 REEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNK 1239
Score = 30.4 bits (67), Expect = 6.3
Identities = 20/61 (32%), Positives = 35/61 (57%), Gaps = 2/61 (3%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEE-LERQKREELAQR-VAEERTTRREEESRRL 534
+E +R ++ EQ+ ++ERER+ +EE + RQ++EE R V E ++ + R L
Sbjct: 1854 QEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLL 1913
Query: 535 E 535
E
Sbjct: 1914 E 1914
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 89.0 bits (219), Expect = 1e-17
Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 26/234 (11%)
Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATR----------LLAEK 486
P + P PA + A ++ + + EE R +L +
Sbjct: 707 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 766
Query: 487 RRLAREQREKEERERREQEE-LERQKREELA---QRVAEERTTRREE----ESRRLEAEQ 538
+ R++RE+EE RR+QEE L RQ+ +E+A QR EER + E E RR E E+
Sbjct: 767 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 826
Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598
R++EE L++Q EE A REE E +R +E R+ EEA R+R E E+ ++E LE
Sbjct: 827 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE----LE 882
Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL----TGGTEVSALPCTTNA 648
+++ E + +R ++ EA + Q+ +A+ L T G + + C + A
Sbjct: 883 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQA 936
Score = 71.2 bits (173), Expect = 3e-12
Identities = 46/163 (28%), Positives = 87/163 (53%), Gaps = 25/163 (15%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVAEERTTRREEESRRLE 535
EEA R L E+RR E+R++EE R+++EE + REE AQR EE R EEE+ RL
Sbjct: 811 EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 870
Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER--------------- 580
E+ K ++L+ Q ++ +R+R++ + A R+ +++ + ++ A+
Sbjct: 871 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTT 930
Query: 581 ---------VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
+ + ++ +RE Q R E++++ E+MK ++ +
Sbjct: 931 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 973
Score = 53.1 bits (126), Expect = 9e-07
Identities = 26/87 (29%), Positives = 53/87 (60%), Gaps = 2/87 (2%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
++ + R ++EE K+ E+ ++EE R+ E+ + R++R EE+RQ++E +E
Sbjct: 759 QEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 818
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQK 152
E+RR+ EE++ + E ++R+ E + K
Sbjct: 819 ERRRE--EEERRKQEELLRKQEEEAAK 843
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 24/157 (15%)
Query: 475 DPEEATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
+ EEA R L E R AR + E+EER+R+ ELE Q+++EL + + +++E
Sbjct: 847 EEEEAQRRLEENRLRMEEEAARLRHEEEERKRK---ELEVQRQKELMR-----QRQQQQE 898
Query: 530 ESRRLEAEQAREKEEQLQ--------RQAEERALREREEAERAQRQKEEEAR---VREEA 578
RRL+ +Q +++ Q++ +Q+ A + + A+ QK EE R +REE
Sbjct: 899 ALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQ 958
Query: 579 ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
R ++E K Q+++Q++ ++ + K + T++
Sbjct: 959 RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS 995
Score = 50.8 bits (120), Expect = 4e-06
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 21/109 (19%)
Query: 65 DRQRLARERREE-----REKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQK 116
+ + LAR ++EE RE+++A R +REE RQ E + LEER++ EE+R++
Sbjct: 775 EEEELARRKQEEALRRQREQEIALRR----QREEEERQQQEEALRRLEERRREEEERRKQ 830
Query: 117 EERRR---------AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
EE R A EE+ ++RLEE++ R E R ++ K+K
Sbjct: 831 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 879
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/98 (27%), Positives = 55/98 (56%), Gaps = 11/98 (11%)
Query: 62 RVDDRQRLARERREERE--KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ-----R 114
R+++R+R ERR++ E ++ W EE A ++ LEE + R+EE+
Sbjct: 816 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA----QRRLEENRLRMEEEAARLRH 871
Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
++EER+R +E +R++ L +++ + +RR ++ Q+
Sbjct: 872 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQ 909
Score = 48.1 bits (113), Expect = 3e-05
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 17/134 (12%)
Query: 19 RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
RS + PD+ + + + +S+P G + + P P L E+ ++ E
Sbjct: 675 RSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL----------EQLQQLE 724
Query: 79 KQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAVEEKRRQRLEED-- 135
K AA+ LE+E R + K EE +KR EE +RQ+EE R EE+R++R EE+
Sbjct: 725 KAKAAK----LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 780
Query: 136 KERHEAVVRRTMER 149
+ + E +RR E+
Sbjct: 781 RRKQEEALRRQREQ 794
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 5/93 (5%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+R ER+ + E + EI+ ++EE ++ E+ L RK+ +RQ+E+
Sbjct: 743 KREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---- 798
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
RRQR EE++++ E +RR ER ++ +++ +
Sbjct: 799 -RRQREEEERQQQEEALRRLEERRREEEERRKQ 830
Score = 40.8 bits (94), Expect = 0.005
Identities = 24/74 (32%), Positives = 41/74 (55%), Gaps = 1/74 (1%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+ A+ REE E Q E EE AR +E+ E ++K LE QRQKE R+ ++
Sbjct: 839 EEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEE-ERKRKELEVQRQKELMRQRQQQQ 897
Query: 127 KRRQRLEEDKERHE 140
+ +RL++ +++ +
Sbjct: 898 EALRRLQQQQQQQQ 911
Score = 38.9 bits (89), Expect = 0.018
Identities = 19/56 (33%), Positives = 33/56 (58%)
Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ LE+ K EQ ++E RA EE+ R+R EE + + E ++RR E +K +++
Sbjct: 721 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 776
Score = 36.6 bits (83), Expect = 0.088
Identities = 40/184 (21%), Positives = 81/184 (44%), Gaps = 11/184 (5%)
Query: 386 EKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAP 445
E+E Q+ E L+ ++ EER E EV M A
Sbjct: 848 EEEAQRRLEENRLRMEEEAARLRHEE-EERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 906
Query: 446 APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ----REKEERER 501
A + PSS+ S T+ + +AT LAE ++L E+ RE++ R++
Sbjct: 907 QQQQQLAQMKLPSSSTWGQQSNTTACQS----QATLSLAEIQKLEEERERQLREEQRRQQ 962
Query: 502 REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561
RE + +Q++++ Q+++ + + + E +E+ Q+Q+Q +++ ++ ++
Sbjct: 963 RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ--QQHQQP 1020
Query: 562 ERAQ 565
RA+
Sbjct: 1021 NRAR 1024
Score = 32.0 bits (71), Expect = 2.2
Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 34/129 (26%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R+ + AR R EE E++ +E+ ++E RQ ++ +E +RL++Q+Q+++ +
Sbjct: 859 RLRMEEEAARLRHEEEERK--RKELEVQRQKELMRQRQQQ--QEALRRLQQQQQQQQLAQ 914
Query: 122 AAV------------------------------EEKRRQRLEEDKERHEAVVRRTMERSQ 151
+ EE+ RQ EE + + +++ ++ Q
Sbjct: 915 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQ 974
Query: 152 KPKQKHNRW 160
+ +QK + W
Sbjct: 975 QQQQKLSGW 983
Score = 30.8 bits (68), Expect = 4.8
Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 14/160 (8%)
Query: 355 KAAPAQVRPPSPGNIRPVKR---EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEAT 411
+ + + RP +P + + + E K EP+ + EK ++ E SL + P + +E
Sbjct: 366 QTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPS-RGDEMV 424
Query: 412 VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA 471
+ + P + P+ ++P P P P P+P + + V A S
Sbjct: 425 ADVQQPL---------SQIPSDTASPL-LILPPPVPNPSPTLRPVETPVVGAPGMGSVST 474
Query: 472 GTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK 511
D E L + ++ ++ + R +L+ +
Sbjct: 475 EPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHR 514
Score = 30.4 bits (67), Expect = 6.3
Identities = 36/155 (23%), Positives = 72/155 (46%), Gaps = 36/155 (23%)
Query: 39 PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQH 98
P+S+ GQ +N + + L + + Q+L EERE+QL REE+ RQ
Sbjct: 918 PSSSTWGQQSNTTACQSQA--TLSLAEIQKL----EEERERQL---------REEQRRQQ 962
Query: 99 YEKHLEERKKRLEEQRQKEERR--------RAAVEEKRRQRLEEDKERHEAVVRRTMERS 150
E K L++Q+Q+++++ + + K +++++ R ++ ++
Sbjct: 963 -----RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1017
Query: 151 QKPKQKHN------RWSWGGSLHGSPSIHSADPDR 179
Q+P + N S G S+ G SI++ P++
Sbjct: 1018 QQPNRARNNTHSNLHTSIGNSVWG--SINTGPPNQ 1050
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 89.0 bits (219), Expect = 1e-17
Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 26/234 (11%)
Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATR----------LLAEK 486
P + P PA + A ++ + + EE R +L +
Sbjct: 734 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 793
Query: 487 RRLAREQREKEERERREQEE-LERQKREELA---QRVAEERTTRREE----ESRRLEAEQ 538
+ R++RE+EE RR+QEE L RQ+ +E+A QR EER + E E RR E E+
Sbjct: 794 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 853
Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598
R++EE L++Q EE A REE E +R +E R+ EEA R+R E E+ ++E LE
Sbjct: 854 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE----LE 909
Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL----TGGTEVSALPCTTNA 648
+++ E + +R ++ EA + Q+ +A+ L T G + + C + A
Sbjct: 910 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQA 963
Score = 71.2 bits (173), Expect = 3e-12
Identities = 46/163 (28%), Positives = 87/163 (53%), Gaps = 25/163 (15%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVAEERTTRREEESRRLE 535
EEA R L E+RR E+R++EE R+++EE + REE AQR EE R EEE+ RL
Sbjct: 838 EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 897
Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER--------------- 580
E+ K ++L+ Q ++ +R+R++ + A R+ +++ + ++ A+
Sbjct: 898 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTT 957
Query: 581 ---------VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
+ + ++ +RE Q R E++++ E+MK ++ +
Sbjct: 958 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 1000
Score = 53.1 bits (126), Expect = 9e-07
Identities = 26/87 (29%), Positives = 53/87 (60%), Gaps = 2/87 (2%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
++ + R ++EE K+ E+ ++EE R+ E+ + R++R EE+RQ++E +E
Sbjct: 786 QEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 845
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQK 152
E+RR+ EE++ + E ++R+ E + K
Sbjct: 846 ERRRE--EEERRKQEELLRKQEEEAAK 870
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 24/157 (15%)
Query: 475 DPEEATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
+ EEA R L E R AR + E+EER+R+ ELE Q+++EL + + +++E
Sbjct: 874 EEEEAQRRLEENRLRMEEEAARLRHEEEERKRK---ELEVQRQKELMR-----QRQQQQE 925
Query: 530 ESRRLEAEQAREKEEQLQ--------RQAEERALREREEAERAQRQKEEEAR---VREEA 578
RRL+ +Q +++ Q++ +Q+ A + + A+ QK EE R +REE
Sbjct: 926 ALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQ 985
Query: 579 ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
R ++E K Q+++Q++ ++ + K + T++
Sbjct: 986 RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS 1022
Score = 50.8 bits (120), Expect = 4e-06
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 21/109 (19%)
Query: 65 DRQRLARERREE-----REKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQK 116
+ + LAR ++EE RE+++A R +REE RQ E + LEER++ EE+R++
Sbjct: 802 EEEELARRKQEEALRRQREQEIALRR----QREEEERQQQEEALRRLEERRREEEERRKQ 857
Query: 117 EERRR---------AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
EE R A EE+ ++RLEE++ R E R ++ K+K
Sbjct: 858 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 906
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/98 (27%), Positives = 55/98 (56%), Gaps = 11/98 (11%)
Query: 62 RVDDRQRLARERREERE--KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ-----R 114
R+++R+R ERR++ E ++ W EE A ++ LEE + R+EE+
Sbjct: 843 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA----QRRLEENRLRMEEEAARLRH 898
Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
++EER+R +E +R++ L +++ + +RR ++ Q+
Sbjct: 899 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQ 936
Score = 48.1 bits (113), Expect = 3e-05
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 17/134 (12%)
Query: 19 RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
RS + PD+ + + + +S+P G + + P P L E+ ++ E
Sbjct: 702 RSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL----------EQLQQLE 751
Query: 79 KQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAVEEKRRQRLEED-- 135
K AA+ LE+E R + K EE +KR EE +RQ+EE R EE+R++R EE+
Sbjct: 752 KAKAAK----LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 807
Query: 136 KERHEAVVRRTMER 149
+ + E +RR E+
Sbjct: 808 RRKQEEALRRQREQ 821
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 5/93 (5%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+R ER+ + E + EI+ ++EE ++ E+ L RK+ +RQ+E+
Sbjct: 770 KREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---- 825
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
RRQR EE++++ E +RR ER ++ +++ +
Sbjct: 826 -RRQREEEERQQQEEALRRLEERRREEEERRKQ 857
Score = 40.8 bits (94), Expect = 0.005
Identities = 24/74 (32%), Positives = 41/74 (55%), Gaps = 1/74 (1%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+ A+ REE E Q E EE AR +E+ E ++K LE QRQKE R+ ++
Sbjct: 866 EEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEE-ERKRKELEVQRQKELMRQRQQQQ 924
Query: 127 KRRQRLEEDKERHE 140
+ +RL++ +++ +
Sbjct: 925 EALRRLQQQQQQQQ 938
Score = 38.9 bits (89), Expect = 0.018
Identities = 19/56 (33%), Positives = 33/56 (58%)
Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ LE+ K EQ ++E RA EE+ R+R EE + + E ++RR E +K +++
Sbjct: 748 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 803
Score = 36.6 bits (83), Expect = 0.088
Identities = 40/184 (21%), Positives = 81/184 (44%), Gaps = 11/184 (5%)
Query: 386 EKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAP 445
E+E Q+ E L+ ++ EER E EV M A
Sbjct: 875 EEEAQRRLEENRLRMEEEAARLRHEE-EERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 933
Query: 446 APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ----REKEERER 501
A + PSS+ S T+ + +AT LAE ++L E+ RE++ R++
Sbjct: 934 QQQQQLAQMKLPSSSTWGQQSNTTACQS----QATLSLAEIQKLEEERERQLREEQRRQQ 989
Query: 502 REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561
RE + +Q++++ Q+++ + + + E +E+ Q+Q+Q +++ ++ ++
Sbjct: 990 RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ--QQHQQP 1047
Query: 562 ERAQ 565
RA+
Sbjct: 1048 NRAR 1051
Score = 32.0 bits (71), Expect = 2.2
Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 34/129 (26%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R+ + AR R EE E++ +E+ ++E RQ ++ +E +RL++Q+Q+++ +
Sbjct: 886 RLRMEEEAARLRHEEEERK--RKELEVQRQKELMRQRQQQ--QEALRRLQQQQQQQQLAQ 941
Query: 122 AAV------------------------------EEKRRQRLEEDKERHEAVVRRTMERSQ 151
+ EE+ RQ EE + + +++ ++ Q
Sbjct: 942 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQ 1001
Query: 152 KPKQKHNRW 160
+ +QK + W
Sbjct: 1002 QQQQKLSGW 1010
Score = 30.8 bits (68), Expect = 4.8
Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 14/160 (8%)
Query: 355 KAAPAQVRPPSPGNIRPVKR---EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEAT 411
+ + + RP +P + + + E K EP+ + EK ++ E SL + P + +E
Sbjct: 393 QTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPS-RGDEMV 451
Query: 412 VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA 471
+ + P + P+ ++P P P P P+P + + V A S
Sbjct: 452 ADVQQPL---------SQIPSDTASPL-LILPPPVPNPSPTLRPVETPVVGAPGMGSVST 501
Query: 472 GTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK 511
D E L + ++ ++ + R +L+ +
Sbjct: 502 EPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHR 541
Score = 30.4 bits (67), Expect = 6.3
Identities = 36/155 (23%), Positives = 72/155 (46%), Gaps = 36/155 (23%)
Query: 39 PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQH 98
P+S+ GQ +N + + L + + Q+L EERE+QL REE+ RQ
Sbjct: 945 PSSSTWGQQSNTTACQSQA--TLSLAEIQKL----EEERERQL---------REEQRRQQ 989
Query: 99 YEKHLEERKKRLEEQRQKEERR--------RAAVEEKRRQRLEEDKERHEAVVRRTMERS 150
E K L++Q+Q+++++ + + K +++++ R ++ ++
Sbjct: 990 -----RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1044
Query: 151 QKPKQKHN------RWSWGGSLHGSPSIHSADPDR 179
Q+P + N S G S+ G SI++ P++
Sbjct: 1045 QQPNRARNNTHSNLHTSIGNSVWG--SINTGPPNQ 1077
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 89.0 bits (219), Expect = 1e-17
Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 26/234 (11%)
Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATR----------LLAEK 486
P + P PA + A ++ + + EE R +L +
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 772
Query: 487 RRLAREQREKEERERREQEE-LERQKREELA---QRVAEERTTRREE----ESRRLEAEQ 538
+ R++RE+EE RR+QEE L RQ+ +E+A QR EER + E E RR E E+
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598
R++EE L++Q EE A REE E +R +E R+ EEA R+R E E+ ++E LE
Sbjct: 833 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE----LE 888
Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL----TGGTEVSALPCTTNA 648
+++ E + +R ++ EA + Q+ +A+ L T G + + C + A
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQA 942
Score = 71.2 bits (173), Expect = 3e-12
Identities = 46/163 (28%), Positives = 87/163 (53%), Gaps = 25/163 (15%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVAEERTTRREEESRRLE 535
EEA R L E+RR E+R++EE R+++EE + REE AQR EE R EEE+ RL
Sbjct: 817 EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 876
Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER--------------- 580
E+ K ++L+ Q ++ +R+R++ + A R+ +++ + ++ A+
Sbjct: 877 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTT 936
Query: 581 ---------VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
+ + ++ +RE Q R E++++ E+MK ++ +
Sbjct: 937 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 979
Score = 53.1 bits (126), Expect = 9e-07
Identities = 26/87 (29%), Positives = 53/87 (60%), Gaps = 2/87 (2%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
++ + R ++EE K+ E+ ++EE R+ E+ + R++R EE+RQ++E +E
Sbjct: 765 QEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 824
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQK 152
E+RR+ EE++ + E ++R+ E + K
Sbjct: 825 ERRRE--EEERRKQEELLRKQEEEAAK 849
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 24/157 (15%)
Query: 475 DPEEATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
+ EEA R L E R AR + E+EER+R+ ELE Q+++EL + + +++E
Sbjct: 853 EEEEAQRRLEENRLRMEEEAARLRHEEEERKRK---ELEVQRQKELMR-----QRQQQQE 904
Query: 530 ESRRLEAEQAREKEEQLQ--------RQAEERALREREEAERAQRQKEEEAR---VREEA 578
RRL+ +Q +++ Q++ +Q+ A + + A+ QK EE R +REE
Sbjct: 905 ALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQ 964
Query: 579 ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
R ++E K Q+++Q++ ++ + K + T++
Sbjct: 965 RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS 1001
Score = 50.8 bits (120), Expect = 4e-06
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 21/109 (19%)
Query: 65 DRQRLARERREE-----REKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQK 116
+ + LAR ++EE RE+++A R +REE RQ E + LEER++ EE+R++
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRR----QREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 117 EERRR---------AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
EE R A EE+ ++RLEE++ R E R ++ K+K
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/98 (27%), Positives = 55/98 (56%), Gaps = 11/98 (11%)
Query: 62 RVDDRQRLARERREERE--KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ-----R 114
R+++R+R ERR++ E ++ W EE A ++ LEE + R+EE+
Sbjct: 822 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA----QRRLEENRLRMEEEAARLRH 877
Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
++EER+R +E +R++ L +++ + +RR ++ Q+
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQ 915
Score = 48.1 bits (113), Expect = 3e-05
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 17/134 (12%)
Query: 19 RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
RS + PD+ + + + +S+P G + + P P L E+ ++ E
Sbjct: 681 RSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL----------EQLQQLE 730
Query: 79 KQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAVEEKRRQRLEED-- 135
K AA+ LE+E R + K EE +KR EE +RQ+EE R EE+R++R EE+
Sbjct: 731 KAKAAK----LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 786
Query: 136 KERHEAVVRRTMER 149
+ + E +RR E+
Sbjct: 787 RRKQEEALRRQREQ 800
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 5/93 (5%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+R ER+ + E + EI+ ++EE ++ E+ L RK+ +RQ+E+
Sbjct: 749 KREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---- 804
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
RRQR EE++++ E +RR ER ++ +++ +
Sbjct: 805 -RRQREEEERQQQEEALRRLEERRREEEERRKQ 836
Score = 40.8 bits (94), Expect = 0.005
Identities = 24/74 (32%), Positives = 41/74 (55%), Gaps = 1/74 (1%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+ A+ REE E Q E EE AR +E+ E ++K LE QRQKE R+ ++
Sbjct: 845 EEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEE-ERKRKELEVQRQKELMRQRQQQQ 903
Query: 127 KRRQRLEEDKERHE 140
+ +RL++ +++ +
Sbjct: 904 EALRRLQQQQQQQQ 917
Score = 38.9 bits (89), Expect = 0.018
Identities = 19/56 (33%), Positives = 33/56 (58%)
Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ LE+ K EQ ++E RA EE+ R+R EE + + E ++RR E +K +++
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Score = 36.6 bits (83), Expect = 0.088
Identities = 40/184 (21%), Positives = 81/184 (44%), Gaps = 11/184 (5%)
Query: 386 EKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAP 445
E+E Q+ E L+ ++ EER E EV M A
Sbjct: 854 EEEAQRRLEENRLRMEEEAARLRHEE-EERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 912
Query: 446 APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ----REKEERER 501
A + PSS+ S T+ + +AT LAE ++L E+ RE++ R++
Sbjct: 913 QQQQQLAQMKLPSSSTWGQQSNTTACQS----QATLSLAEIQKLEEERERQLREEQRRQQ 968
Query: 502 REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561
RE + +Q++++ Q+++ + + + E +E+ Q+Q+Q +++ ++ ++
Sbjct: 969 RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ--QQHQQP 1026
Query: 562 ERAQ 565
RA+
Sbjct: 1027 NRAR 1030
Score = 32.0 bits (71), Expect = 2.2
Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 34/129 (26%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R+ + AR R EE E++ +E+ ++E RQ ++ +E +RL++Q+Q+++ +
Sbjct: 865 RLRMEEEAARLRHEEEERK--RKELEVQRQKELMRQRQQQ--QEALRRLQQQQQQQQLAQ 920
Query: 122 AAV------------------------------EEKRRQRLEEDKERHEAVVRRTMERSQ 151
+ EE+ RQ EE + + +++ ++ Q
Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQ 980
Query: 152 KPKQKHNRW 160
+ +QK + W
Sbjct: 981 QQQQKLSGW 989
Score = 30.8 bits (68), Expect = 4.8
Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 14/160 (8%)
Query: 355 KAAPAQVRPPSPGNIRPVKR---EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEAT 411
+ + + RP +P + + + E K EP+ + EK ++ E SL + P + +E
Sbjct: 372 QTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPS-RGDEMV 430
Query: 412 VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA 471
+ + P + P+ ++P P P P P+P + + V A S
Sbjct: 431 ADVQQPL---------SQIPSDTASPL-LILPPPVPNPSPTLRPVETPVVGAPGMGSVST 480
Query: 472 GTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK 511
D E L + ++ ++ + R +L+ +
Sbjct: 481 EPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHR 520
Score = 30.4 bits (67), Expect = 6.3
Identities = 36/155 (23%), Positives = 72/155 (46%), Gaps = 36/155 (23%)
Query: 39 PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQH 98
P+S+ GQ +N + + L + + Q+L EERE+QL REE+ RQ
Sbjct: 924 PSSSTWGQQSNTTACQSQA--TLSLAEIQKL----EEERERQL---------REEQRRQQ 968
Query: 99 YEKHLEERKKRLEEQRQKEERR--------RAAVEEKRRQRLEEDKERHEAVVRRTMERS 150
E K L++Q+Q+++++ + + K +++++ R ++ ++
Sbjct: 969 -----RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1023
Query: 151 QKPKQKHN------RWSWGGSLHGSPSIHSADPDR 179
Q+P + N S G S+ G SI++ P++
Sbjct: 1024 QQPNRARNNTHSNLHTSIGNSVWG--SINTGPPNQ 1056
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 89.0 bits (219), Expect = 1e-17
Identities = 71/234 (30%), Positives = 114/234 (48%), Gaps = 26/234 (11%)
Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATR----------LLAEK 486
P + P PA + A ++ + + EE R +L +
Sbjct: 713 PLDTTTPGPALEQLQQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQ 772
Query: 487 RRLAREQREKEERERREQEE-LERQKREELA---QRVAEERTTRREE----ESRRLEAEQ 538
+ R++RE+EE RR+QEE L RQ+ +E+A QR EER + E E RR E E+
Sbjct: 773 QEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLEERRREEEE 832
Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLE 598
R++EE L++Q EE A REE E +R +E R+ EEA R+R E E+ ++E LE
Sbjct: 833 RRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKE----LE 888
Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL----TGGTEVSALPCTTNA 648
+++ E + +R ++ EA + Q+ +A+ L T G + + C + A
Sbjct: 889 VQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQA 942
Score = 71.2 bits (173), Expect = 3e-12
Identities = 46/163 (28%), Positives = 87/163 (53%), Gaps = 25/163 (15%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL-AQRVAEERTTRREEESRRLE 535
EEA R L E+RR E+R++EE R+++EE + REE AQR EE R EEE+ RL
Sbjct: 817 EEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLR 876
Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER--------------- 580
E+ K ++L+ Q ++ +R+R++ + A R+ +++ + ++ A+
Sbjct: 877 HEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTT 936
Query: 581 ---------VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
+ + ++ +RE Q R E++++ E+MK ++ +
Sbjct: 937 ACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQ 979
Score = 53.1 bits (126), Expect = 9e-07
Identities = 26/87 (29%), Positives = 53/87 (60%), Gaps = 2/87 (2%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
++ + R ++EE K+ E+ ++EE R+ E+ + R++R EE+RQ++E +E
Sbjct: 765 QEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRLE 824
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQK 152
E+RR+ EE++ + E ++R+ E + K
Sbjct: 825 ERRRE--EEERRKQEELLRKQEEEAAK 849
Score = 52.4 bits (124), Expect = 2e-06
Identities = 44/157 (28%), Positives = 83/157 (52%), Gaps = 24/157 (15%)
Query: 475 DPEEATRLLAEKR-----RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
+ EEA R L E R AR + E+EER+R+ ELE Q+++EL + + +++E
Sbjct: 853 EEEEAQRRLEENRLRMEEEAARLRHEEEERKRK---ELEVQRQKELMR-----QRQQQQE 904
Query: 530 ESRRLEAEQAREKEEQLQ--------RQAEERALREREEAERAQRQKEEEAR---VREEA 578
RRL+ +Q +++ Q++ +Q+ A + + A+ QK EE R +REE
Sbjct: 905 ALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQ 964
Query: 579 ERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
R ++E K Q+++Q++ ++ + K + T++
Sbjct: 965 RRQQRELMKALQQQQQQQQQKLSGWGNVSKPSGTTKS 1001
Score = 50.8 bits (120), Expect = 4e-06
Identities = 37/109 (33%), Positives = 59/109 (54%), Gaps = 21/109 (19%)
Query: 65 DRQRLARERREE-----REKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQK 116
+ + LAR ++EE RE+++A R +REE RQ E + LEER++ EE+R++
Sbjct: 781 EEEELARRKQEEALRRQREQEIALRR----QREEEERQQQEEALRRLEERRREEEERRKQ 836
Query: 117 EERRR---------AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
EE R A EE+ ++RLEE++ R E R ++ K+K
Sbjct: 837 EELLRKQEEEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRK 885
Score = 48.5 bits (114), Expect = 2e-05
Identities = 27/98 (27%), Positives = 55/98 (56%), Gaps = 11/98 (11%)
Query: 62 RVDDRQRLARERREERE--KQLAAREIVWLEREERARQHYEKHLEERKKRLEEQ-----R 114
R+++R+R ERR++ E ++ W EE A ++ LEE + R+EE+
Sbjct: 822 RLEERRREEEERRKQEELLRKQEEEAAKWAREEEEA----QRRLEENRLRMEEEAARLRH 877
Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
++EER+R +E +R++ L +++ + +RR ++ Q+
Sbjct: 878 EEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQ 915
Score = 48.1 bits (113), Expect = 3e-05
Identities = 41/134 (30%), Positives = 67/134 (50%), Gaps = 17/134 (12%)
Query: 19 RSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREERE 78
RS + PD+ + + + +S+P G + + P P L E+ ++ E
Sbjct: 681 RSVSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPAL----------EQLQQLE 730
Query: 79 KQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAVEEKRRQRLEED-- 135
K AA+ LE+E R + K EE +KR EE +RQ+EE R EE+R++R EE+
Sbjct: 731 KAKAAK----LEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELA 786
Query: 136 KERHEAVVRRTMER 149
+ + E +RR E+
Sbjct: 787 RRKQEEALRRQREQ 800
Score = 46.2 bits (108), Expect = 1e-04
Identities = 26/93 (27%), Positives = 51/93 (54%), Gaps = 5/93 (5%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+R ER+ + E + EI+ ++EE ++ E+ L RK+ +RQ+E+
Sbjct: 749 KREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIAL---- 804
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
RRQR EE++++ E +RR ER ++ +++ +
Sbjct: 805 -RRQREEEERQQQEEALRRLEERRREEEERRKQ 836
Score = 40.8 bits (94), Expect = 0.005
Identities = 24/74 (32%), Positives = 41/74 (55%), Gaps = 1/74 (1%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+ A+ REE E Q E EE AR +E+ E ++K LE QRQKE R+ ++
Sbjct: 845 EEAAKWAREEEEAQRRLEENRLRMEEEAARLRHEEE-ERKRKELEVQRQKELMRQRQQQQ 903
Query: 127 KRRQRLEEDKERHE 140
+ +RL++ +++ +
Sbjct: 904 EALRRLQQQQQQQQ 917
Score = 38.9 bits (89), Expect = 0.018
Identities = 19/56 (33%), Positives = 33/56 (58%)
Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ LE+ K EQ ++E RA EE+ R+R EE + + E ++RR E +K +++
Sbjct: 727 QQLEKAKAAKLEQERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREE 782
Score = 36.6 bits (83), Expect = 0.088
Identities = 40/184 (21%), Positives = 81/184 (44%), Gaps = 11/184 (5%)
Query: 386 EKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAP 445
E+E Q+ E L+ ++ EER E EV M A
Sbjct: 854 EEEAQRRLEENRLRMEEEAARLRHEE-EERKRKELEVQRQKELMRQRQQQQEALRRLQQQ 912
Query: 446 APVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ----REKEERER 501
A + PSS+ S T+ + +AT LAE ++L E+ RE++ R++
Sbjct: 913 QQQQQLAQMKLPSSSTWGQQSNTTACQS----QATLSLAEIQKLEEERERQLREEQRRQQ 968
Query: 502 REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEA 561
RE + +Q++++ Q+++ + + + E +E+ Q+Q+Q +++ ++ ++
Sbjct: 969 RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQ--QQHQQP 1026
Query: 562 ERAQ 565
RA+
Sbjct: 1027 NRAR 1030
Score = 32.0 bits (71), Expect = 2.2
Identities = 26/129 (20%), Positives = 57/129 (44%), Gaps = 34/129 (26%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R+ + AR R EE E++ +E+ ++E RQ ++ +E +RL++Q+Q+++ +
Sbjct: 865 RLRMEEEAARLRHEEEERK--RKELEVQRQKELMRQRQQQ--QEALRRLQQQQQQQQLAQ 920
Query: 122 AAV------------------------------EEKRRQRLEEDKERHEAVVRRTMERSQ 151
+ EE+ RQ EE + + +++ ++ Q
Sbjct: 921 MKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQ 980
Query: 152 KPKQKHNRW 160
+ +QK + W
Sbjct: 981 QQQQKLSGW 989
Score = 30.8 bits (68), Expect = 4.8
Identities = 30/160 (18%), Positives = 62/160 (38%), Gaps = 14/160 (8%)
Query: 355 KAAPAQVRPPSPGNIRPVKR---EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEAT 411
+ + + RP +P + + + E K EP+ + EK ++ E SL + P + +E
Sbjct: 372 QTSSSSARPGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPS-RGDEMV 430
Query: 412 VEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA 471
+ + P + P+ ++P P P P P+P + + V A S
Sbjct: 431 ADVQQPL---------SQIPSDTASPL-LILPPPVPNPSPTLRPVETPVVGAPGMGSVST 480
Query: 472 GTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK 511
D E L + ++ ++ + R +L+ +
Sbjct: 481 EPDDEEGLKHLEQQAEKMVAYLQDSALDDERLASKLQEHR 520
Score = 30.4 bits (67), Expect = 6.3
Identities = 36/155 (23%), Positives = 72/155 (46%), Gaps = 36/155 (23%)
Query: 39 PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQH 98
P+S+ GQ +N + + L + + Q+L EERE+QL REE+ RQ
Sbjct: 924 PSSSTWGQQSNTTACQSQA--TLSLAEIQKL----EEERERQL---------REEQRRQQ 968
Query: 99 YEKHLEERKKRLEEQRQKEERR--------RAAVEEKRRQRLEEDKERHEAVVRRTMERS 150
E K L++Q+Q+++++ + + K +++++ R ++ ++
Sbjct: 969 -----RELMKALQQQQQQQQQKLSGWGNVSKPSGTTKSLLEIQQEEARQMQKQQQQQQQH 1023
Query: 151 QKPKQKHN------RWSWGGSLHGSPSIHSADPDR 179
Q+P + N S G S+ G SI++ P++
Sbjct: 1024 QQPNRARNNTHSNLHTSIGNSVWG--SINTGPPNQ 1056
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 87.8 bits (216), Expect = 3e-17
Identities = 62/189 (32%), Positives = 103/189 (54%), Gaps = 27/189 (14%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQE-----ELERQKREELAQRVAEER---TTRRE 528
E TR +K R + ++E+ ERE+R++E + ER K+E+ +R EER RRE
Sbjct: 44 EIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRRE 103
Query: 529 EESRRLEAEQAREKEEQLQR--------QAEERALREREEAERAQRQKEEEARVREEAER 580
+E++ E ++ R+K+E+ +R + E + R+REE + +R+KEE + RE ER
Sbjct: 104 KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKER 163
Query: 581 VRQER----EKHFQREEQERLERKK-------RLEEIMKRTRRTEATDKKTSDQRNGDIA 629
++ER EK +R+E+ER ERKK R +E ++ RR ++K ++R +
Sbjct: 164 KKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQ 223
Query: 630 KGALTGGTE 638
K T E
Sbjct: 224 KDRQTNWRE 232
Score = 80.9 bits (198), Expect = 4e-15
Identities = 52/149 (34%), Positives = 92/149 (61%), Gaps = 7/149 (4%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA-EQAREKE 543
E+R + +REKE +E E+E+ ++++++E + E + R+EE +R E E+ R+KE
Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 544 E-QLQRQAEERALREREE-AERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKK 601
E + +R+ +ER RER++ E+ + +KE+E + R++ ER R+ER+K +RE +ER ERKK
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKK--ERERKERRERKK 210
Query: 602 RLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
E K R+ E + ++ R + K
Sbjct: 211 --ERKKKEERKKERQKDRQTNWREKERGK 237
Score = 75.1 bits (183), Expect = 2e-13
Identities = 45/138 (32%), Positives = 78/138 (56%), Gaps = 5/138 (3%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRRE-EESRRLE 535
E+ R EK+ R +E +ERER+E+ + E +K E R EER RE +E ++ E
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERE---RKKEEREKERERKERKKRE 167
Query: 536 AEQAREKEEQL-QRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
+Q EKEE+ +++ +ER RER ER + ++ +E R R++ + ++ER+K Q++ Q
Sbjct: 168 RKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQ 227
Query: 595 ERLERKKRLEEIMKRTRR 612
K+R + K ++
Sbjct: 228 TNWREKERGKRERKERKK 245
Score = 67.4 bits (163), Expect = 5e-11
Identities = 35/131 (26%), Positives = 74/131 (56%), Gaps = 4/131 (3%)
Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKE 543
+E R RE ++E ++ + E ++++RE ++ E+ +RE + + E+ +E+
Sbjct: 36 SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER 95
Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
E+ +R+ E +E +E E +++K++E + R + +ERE+ +R+ +ER ER+++
Sbjct: 96 ERKKRRRE----KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKK 151
Query: 604 EEIMKRTRRTE 614
EE K R E
Sbjct: 152 EEREKERERKE 162
Score = 66.6 bits (161), Expect = 8e-11
Identities = 42/127 (33%), Positives = 76/127 (59%), Gaps = 9/127 (7%)
Query: 498 ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRE 557
+ E RE+E ++E +R +E + RRE E R+ E E+ R++E + + E++ R+
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRE---RGKKEKKGERK 91
Query: 558 REEAERAQRQKEEEARVREEAERVRQEREKHFQR-----EEQERLERKKRLEEIMKRTRR 612
+EE ER +R++E+E + EE E+ +++ +K R +E+ER E +KR EE +R R+
Sbjct: 92 KEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR-EERKERERK 150
Query: 613 TEATDKK 619
E +K+
Sbjct: 151 KEEREKE 157
Score = 58.9 bits (141), Expect = 2e-08
Identities = 32/111 (28%), Positives = 64/111 (57%), Gaps = 1/111 (0%)
Query: 520 AEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE 579
+E R RE E+R+ E ++ RE E + +R+ E+ RERE+ + +R K+E+ R++ E
Sbjct: 36 SEIREREREIETRK-EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 580 RVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
R R++R + + +E E E++K+ E+ + E +++ ++R + K
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK 145
Score = 53.1 bits (126), Expect = 9e-07
Identities = 30/99 (30%), Positives = 57/99 (57%), Gaps = 4/99 (4%)
Query: 62 RVDDRQRLARERRE----EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKE 117
R ++R+R R+ RE EREK+ +E ER++ + E+ +ERK+R + +R ++
Sbjct: 135 RKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRK 194
Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
ER++ ++RR+R +E K++ E R +R ++K
Sbjct: 195 ERKKERERKERRERKKERKKKEERKKERQKDRQTNWREK 233
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/106 (33%), Positives = 58/106 (54%), Gaps = 13/106 (12%)
Query: 65 DRQRLARERREEREKQLAAREIVW------LEREERARQHYEKHLEERKKRLEEQRQKEE 118
+R++ RER +ER+++ +E ER++R R+ K EE++KR ++++K+E
Sbjct: 65 EREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKR--KKKEKKE 122
Query: 119 RRRAAVEEKRRQRL-----EEDKERHEAVVRRTMERSQKPKQKHNR 159
R R + E K R+R EE KER R ER +K ++K R
Sbjct: 123 RGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRER 168
Score = 51.2 bits (121), Expect = 3e-06
Identities = 27/99 (27%), Positives = 55/99 (55%), Gaps = 1/99 (1%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYE-KHLEERKKRLEEQRQKEERRRAA 123
+R+R +REER+++ +E ERE + R+ E K + E+++ +E+ +KE ++R
Sbjct: 132 ERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRER 191
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
++R++ E + R R+ E +K +QK + +W
Sbjct: 192 NRKERKKERERKERRERKKERKKKEERKKERQKDRQTNW 230
Score = 48.9 bits (115), Expect = 2e-05
Identities = 35/110 (31%), Positives = 57/110 (51%), Gaps = 13/110 (11%)
Query: 63 VDDRQRLARERREEREKQLAAREIVWLERE-ERARQHYEKHLE--------ERKKRLEEQ 113
++ R+ +ER ER+K+ RE ERE ER R+ +K + ERKKR E+
Sbjct: 45 IETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREK 104
Query: 114 RQKE----ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
KE E+R+ +++R + +E KER R+ ER ++ ++K R
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Score = 47.8 bits (112), Expect = 4e-05
Identities = 31/101 (30%), Positives = 56/101 (55%), Gaps = 8/101 (7%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL-------EEQRQKEE 118
R+R +E++ ER+K+ R+ E+E + + EK ++ KK +E+ +KEE
Sbjct: 79 RERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEE 138
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R+R +E+ R++ E +KER E R+ ER Q +++ R
Sbjct: 139 RKREERKERERKKEEREKER-ERKERKKRERKQVGEKEEER 178
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/91 (31%), Positives = 54/91 (59%), Gaps = 6/91 (6%)
Query: 63 VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEER-KKRLEEQRQKEERRR 121
+ +R+R R+E ++++ + R+ ERE+R R+ ++ ER KK + +R+KEER
Sbjct: 38 IREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER-- 95
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
E K+R+R +E+KE E R+ E+ ++
Sbjct: 96 ---ERKKRRREKENKEGEEKEKRKKKEKKER 123
Score = 47.4 bits (111), Expect = 5e-05
Identities = 24/95 (25%), Positives = 55/95 (57%), Gaps = 4/95 (4%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
+++R +ER++ KQ+ +E ER+E+ R+ +K RK+R +E+ +KE R R
Sbjct: 155 EKERERKERKKRERKQVGEKEE---ERKEKERKERKKRERNRKERKKERERKERRERKK- 210
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E K+++ ++++++ R ER ++ +++ +
Sbjct: 211 ERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 45.8 bits (107), Expect = 1e-04
Identities = 27/97 (27%), Positives = 52/97 (53%), Gaps = 2/97 (2%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYE-KHLEERKKRLEEQRQKEERRRA 122
++R+R R R +E ++ + E++ER R E K E +++R E+R++ ER++
Sbjct: 93 EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
EK R+R E K + V + ER +K +++ +
Sbjct: 153 E-REKERERKERKKRERKQVGEKEEERKEKERKERKK 188
Score = 42.4 bits (98), Expect = 0.002
Identities = 23/96 (23%), Positives = 58/96 (60%), Gaps = 5/96 (5%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
++++ +E+R+++EK+ R E +ER R+ K E +++ +++ +++ER R
Sbjct: 105 ENKEGEEKEKRKKKEKKERGRTSK--EGKERERKEERKREERKERERKKEEREKERERKE 162
Query: 124 VEEKRRQRL---EEDKERHEAVVRRTMERSQKPKQK 156
+++ R+++ EE+++ E R+ ER++K ++K
Sbjct: 163 RKKRERKQVGEKEEERKEKERKERKKRERNRKERKK 198
Score = 39.7 bits (91), Expect = 0.010
Identities = 20/70 (28%), Positives = 40/70 (57%), Gaps = 2/70 (2%)
Query: 90 EREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMER 149
ERE E E +R +E+R++E+R+R +E++R+R +++K+ R ER
Sbjct: 40 EREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER--ER 97
Query: 150 SQKPKQKHNR 159
++ ++K N+
Sbjct: 98 KKRRREKENK 107
Score = 38.9 bits (89), Expect = 0.018
Identities = 20/68 (29%), Positives = 37/68 (54%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
++R+ R+ R++RE+ R+ +E R R+ K EERKK ++ RQ R +
Sbjct: 176 EERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKER 235
Query: 124 VEEKRRQR 131
+ +R++R
Sbjct: 236 GKRERKER 243
Score = 32.3 bits (72), Expect = 1.7
Identities = 14/57 (24%), Positives = 35/57 (61%), Gaps = 3/57 (5%)
Query: 99 YEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
++ + ER++ +E +++ ++ R + +++RR+R + +ER + R ER +K K+
Sbjct: 34 WQSEIREREREIETRKEGKKERESERKKERREREKRKREREK---ERKRERGKKEKK 87
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 83.6 bits (205), Expect = 6e-16
Identities = 51/160 (31%), Positives = 93/160 (58%), Gaps = 10/160 (6%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKRE------ELAQRVAEERTTRREEE 530
E+ R E+ + +R++ E++R+E+ E ER+KR+ E QR ER ++E +
Sbjct: 62 EKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERK 121
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE--RVRQEREKH 588
R E +Q RE++ + +R+ + R R+RE+ ER +R+++ + R +EE E R R +E+
Sbjct: 122 ERERENKQRRERKRKKRRKKKRRKERKREK-ERGKRERKRKKRKKEEREKKRERNRKERK 180
Query: 589 FQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDI 628
+RE +ER ERKK ++ +R ++ D+KT Q + +
Sbjct: 181 KERERKERRERKKERKK-ERRKKKERKKDRKTDRQTDSQV 219
Score = 82.0 bits (201), Expect = 2e-15
Identities = 44/143 (30%), Positives = 86/143 (60%), Gaps = 5/143 (3%)
Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQ 545
+R+ R +REK +RER ++ + ER K+E+ +R ER RE + + E ++ +E++
Sbjct: 35 ERKKERREREKRKREREKERKRERGKKEK-KKRKKRERGKERERKRKEREKQRKERREKE 93
Query: 546 LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLE- 604
+++ +E+ RER++ R +R+K++E + RE + R+ER++ +R+++ R ERK+ E
Sbjct: 94 RRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER 153
Query: 605 ---EIMKRTRRTEATDKKTSDQR 624
E ++ R+ E +KK R
Sbjct: 154 GKRERKRKKRKKEEREKKRERNR 176
Score = 80.5 bits (197), Expect = 5e-15
Identities = 41/143 (28%), Positives = 83/143 (58%), Gaps = 3/143 (2%)
Query: 485 EKRRLAREQREKEER---ERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQARE 541
EKR+ RE+ K ER E++++++ ER K E ++ E++ R E+ RR ++ ++
Sbjct: 44 EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKK 103
Query: 542 KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKK 601
+E + + + E + +ER+E ER +Q+ E R + ++ R+ER++ +R ++ER +K+
Sbjct: 104 RERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKR 163
Query: 602 RLEEIMKRTRRTEATDKKTSDQR 624
+ EE K+ R KK +++
Sbjct: 164 KKEEREKKRERNRKERKKERERK 186
Score = 73.9 bits (180), Expect = 5e-13
Identities = 42/134 (31%), Positives = 76/134 (56%), Gaps = 12/134 (8%)
Query: 491 REQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQA 550
RE K+ER RE+ + ER+K ER R ++ ++ ++ R KE + +R+
Sbjct: 32 RESERKKERREREKRKREREK----------ERKRERGKKEKKKRKKRERGKERERKRKE 81
Query: 551 EERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRT 610
E+ +ER E ER +R+KE+ + RE +R R+ER+K +R+E+ER +++R + KR
Sbjct: 82 REKQRKERREKERRKRKKEK--KKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139
Query: 611 RRTEATDKKTSDQR 624
++ ++K +R
Sbjct: 140 KKKRRKERKREKER 153
Score = 57.0 bits (136), Expect = 6e-08
Identities = 26/118 (22%), Positives = 69/118 (58%), Gaps = 1/118 (0%)
Query: 486 KRRLAREQREKEER-ERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
K+R RE+++K+ER ER + + R+++ + ++ + +RE+E + E ++ + K+E
Sbjct: 107 KQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKE 166
Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKR 602
+ +++ E ++E ER +R++ ++ R +E ++ +++++ R+ ++ R R
Sbjct: 167 EREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLR 224
Score = 56.2 bits (134), Expect = 1e-07
Identities = 28/95 (29%), Positives = 58/95 (61%), Gaps = 1/95 (1%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
+R++ RER +ER+++ +E ++ ER ++ E+ +ER+K+ +E+R+KE R+R
Sbjct: 42 EREKRKREREKERKRERGKKEKKKRKKRERGKER-ERKRKEREKQRKERREKERRKRKKE 100
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
++KR ++ +ER + R+ ER K +++ R
Sbjct: 101 KKKRERKQRGRRERKKKKERKERERENKQRRERKR 135
Score = 53.5 bits (127), Expect = 7e-07
Identities = 30/97 (30%), Positives = 58/97 (59%), Gaps = 12/97 (12%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR---RA 122
R+R R RRE ++K+ ER+ER R++ ++ +RKKR +++R+KE +R R
Sbjct: 104 RERKQRGRRERKKKK---------ERKERERENKQRRERKRKKRRKKKRRKERKREKERG 154
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E KR++R +E++E+ R+ ++ ++ K++ R
Sbjct: 155 KRERKRKKRKKEEREKKRERNRKERKKERERKERRER 191
Score = 53.1 bits (126), Expect = 9e-07
Identities = 31/96 (32%), Positives = 59/96 (61%), Gaps = 9/96 (9%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+ ++R RER +ERE++ RE +R+ER + K +E+KKR +QR + ER++
Sbjct: 62 EKKKRKKRERGKERERKRKERE---KQRKERREKERRKRKKEKKKRERKQRGRRERKK-- 116
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+++R++R E+K+R E R+ +R +K ++K +
Sbjct: 117 -KKERKERERENKQRRE---RKRKKRRKKKRRKERK 148
Score = 52.8 bits (125), Expect = 1e-06
Identities = 34/124 (27%), Positives = 67/124 (54%), Gaps = 5/124 (4%)
Query: 33 KNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLERE 92
K SSR A ++ + S + P R +R++ RER + + ++ R+ ++E
Sbjct: 3 KAISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKE 62
Query: 93 ERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
++ R+ E+ E +KR E ++Q++ERR EK R++ +++K++ E R ER +K
Sbjct: 63 KKKRKKRERGKERERKRKEREKQRKERR-----EKERRKRKKEKKKRERKQRGRRERKKK 117
Query: 153 PKQK 156
++K
Sbjct: 118 KERK 121
Score = 50.8 bits (120), Expect = 4e-06
Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 6/95 (6%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLE-EQRQKEERRRAAV 124
R+ ++R+E REK+ R ++E++ R+ ++ ERKK+ E ++R++E ++R
Sbjct: 79 RKEREKQRKERREKERRKR-----KKEKKKRERKQRGRRERKKKKERKERERENKQRRER 133
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ K+R++ + KER R ER +K ++K R
Sbjct: 134 KRKKRRKKKRRKERKREKERGKRERKRKKRKKEER 168
Score = 50.8 bits (120), Expect = 4e-06
Identities = 25/95 (26%), Positives = 58/95 (61%), Gaps = 1/95 (1%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
+R++ +ERRE +E++ +E ER++R R+ +K E +++ E ++++E +R+
Sbjct: 81 EREKQRKERRE-KERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRR 139
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
++KRR+ + +KER + +R + ++ ++K R
Sbjct: 140 KKKRRKERKREKERGKRERKRKKRKKEEREKKRER 174
Score = 50.1 bits (118), Expect = 8e-06
Identities = 29/95 (30%), Positives = 49/95 (51%), Gaps = 4/95 (4%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
+R+ RE ++ RE++ R +E + + K +RKKR +E+R+K+ R
Sbjct: 119 ERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKE 178
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+K R+R KER E R ER +K ++K +R
Sbjct: 179 RKKERER----KERRERKKERKKERRKKKERKKDR 209
Score = 49.7 bits (117), Expect = 1e-05
Identities = 26/108 (24%), Positives = 62/108 (57%), Gaps = 2/108 (1%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE-ESRRLEAEQAREKE 543
E+ R +R++++R R+++ ER++ +E +R + + ++EE E +R + R+KE
Sbjct: 124 ERENKQRRERKRKKR-RKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKE 182
Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
+ + + E + R++E ++ +R+K+ + + +++ R RE F R
Sbjct: 183 RERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNR 230
Score = 47.0 bits (110), Expect = 6e-05
Identities = 23/88 (26%), Positives = 51/88 (57%), Gaps = 3/88 (3%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
R++ R + +REK+ RE +R++R ++ EK E +K +++R+++ERR E
Sbjct: 138 RRKKKRRKERKREKERGKRE---RKRKKRKKEEREKKRERNRKERKKERERKERRERKKE 194
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKP 153
K+ +R ++++++ R+T + +P
Sbjct: 195 RKKERRKKKERKKDRKTDRQTDSQVFRP 222
Score = 45.8 bits (107), Expect = 1e-04
Identities = 21/98 (21%), Positives = 52/98 (53%), Gaps = 1/98 (1%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R +R++ +E+++ KQ RE ++E + R+ K ERK++ ++++ + R+
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERK-KKKERKERERENKQRRERKRKKRRKKKRRKERK 148
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E +R+R + +++ E +R R ++ K++ +
Sbjct: 149 REKERGKRERKRKKRKKEEREKKRERNRKERKKERERK 186
Score = 45.8 bits (107), Expect = 1e-04
Identities = 26/88 (29%), Positives = 51/88 (57%), Gaps = 2/88 (2%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ--KEERRR 121
+++QR R+R++ R+K+ ER +R R+ ++ EER+K+ E R+ K+ER R
Sbjct: 126 ENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERER 185
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMER 149
E++++R +E +++ E R +R
Sbjct: 186 KERRERKKERKKERRKKKERKKDRKTDR 213
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/80 (27%), Positives = 44/80 (55%), Gaps = 2/80 (2%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
+ E R K+R E+ +K ER R+E++ + ++R+E +R E + RR+++ R+
Sbjct: 150 EKERGKRERKRKKRKKEEREKKRERNRKERK--KERERKERRERKKERKKERRKKKERKK 207
Query: 535 EAEQAREKEEQLQRQAEERA 554
+ + R+ + Q+ R E A
Sbjct: 208 DRKTDRQTDSQVFRPLRESA 227
Score = 40.0 bits (92), Expect = 0.008
Identities = 21/72 (29%), Positives = 42/72 (58%), Gaps = 5/72 (6%)
Query: 558 REEAERAQRQKEEEARVRE-----EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRR 612
+ E+ER + ++E E R RE + ER ++E++K +RE + ERK++ E ++ RR
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERR 90
Query: 613 TEATDKKTSDQR 624
+ K+ +++
Sbjct: 91 EKERRKRKKEKK 102
Score = 39.7 bits (91), Expect = 0.010
Identities = 21/85 (24%), Positives = 47/85 (55%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
++R R+R +ER K+ R+ E E+ R+ K ++ ++R E + +K+ER++ +
Sbjct: 142 KRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRK 201
Query: 126 EKRRQRLEEDKERHEAVVRRTMERS 150
+K R++ + + ++ V R + S
Sbjct: 202 KKERKKDRKTDRQTDSQVFRPLRES 226
Score = 37.4 bits (85), Expect = 0.051
Identities = 27/125 (21%), Positives = 59/125 (47%), Gaps = 5/125 (4%)
Query: 28 KVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIV 87
K +++K R + NK + +++ +ER+ E+E+ R+
Sbjct: 102 KKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRK 161
Query: 88 WLEREERARQHYEKHLEERKKRLEE----QRQKEERRRAAVEEKRRQRLEEDKERHEAVV 143
++EER ++ E++ +ERKK E +R+KE ++ +++R++ + D++ V
Sbjct: 162 KRKKEEREKKR-ERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVF 220
Query: 144 RRTME 148
R E
Sbjct: 221 RPLRE 225
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 82.4 bits (202), Expect = 1e-15
Identities = 64/153 (41%), Positives = 83/153 (54%), Gaps = 9/153 (5%)
Query: 478 EATRLLAEKR-RLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E RL AE+R R+ EQ +K ER E E+ +E +R AEER REEE R E
Sbjct: 268 ERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAE- 326
Query: 537 EQAREKEEQLQRQAEERALREREE---AERAQRQKEEEARVREEAERVRQEREKHFQREE 593
E+ R KEE+ +R AEER + EE AE QR KEEE R EE +R R E E+ + EE
Sbjct: 327 ERQRIKEEE-KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEE 385
Query: 594 QERLERKKRLEEIMKRTRRTEATDKKTSDQRNG 626
Q +R K+LEE + T+ +K + G
Sbjct: 386 Q---KRNKQLEEKKHAMQETKIKGEKVEQKIEG 415
Score = 75.1 bits (183), Expect = 2e-13
Identities = 48/141 (34%), Positives = 79/141 (56%), Gaps = 6/141 (4%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
+ E+ R AE+ RL E+RE+ + E+ ++ ER + E + A+ER R EE R+
Sbjct: 258 EEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERM 317
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
E+ R EE+ QR EE E+ AE QR KEEE R EE +R+++E ++ + ++
Sbjct: 318 REEEKRAAEER-QRIKEE----EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 372
Query: 595 ERLERKKRLE-EIMKRTRRTE 614
R E +++ + E KR ++ E
Sbjct: 373 ARAEEEEKAKVEEQKRNKQLE 393
Score = 74.7 bits (182), Expect = 3e-13
Identities = 52/168 (30%), Positives = 82/168 (48%), Gaps = 9/168 (5%)
Query: 459 STVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQK-REELAQ 517
S N S + + E+ + ++ ++ E +E+ E ER E ER++ + E +
Sbjct: 227 SLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDK 286
Query: 518 RVAEERTTRREEESRRLEAEQAREKEE-QLQRQAEERALREREEAERAQRQKEEEARVRE 576
++A+ER EE + + RE EE + R+ E+RA ER QR KEEE R E
Sbjct: 287 KIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEER------QRIKEEEKRAAE 340
Query: 577 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E +R+++E EK E Q E +KR E +R R E K +Q+
Sbjct: 341 ERQRIKEE-EKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQK 387
Score = 74.7 bits (182), Expect = 3e-13
Identities = 56/170 (32%), Positives = 90/170 (52%), Gaps = 11/170 (6%)
Query: 477 EEATRLLAEKRRL-AREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
E+ ++ E+ R+ A E+ +ERERRE EE ER + EE +R AEER +EEE R E
Sbjct: 283 EQDKKIADERARIEAEEKAAAQERERREAEERERMREEE--KRAAEERQRIKEEEKRAAE 340
Query: 536 AEQAREKEEQLQRQAEERALREREE--AERAQRQKEEEARVREEAERVRQEREKHFQREE 593
E+ R KEE+ + E + ++E E+ AE QR + EE E+A+ Q+R K + ++
Sbjct: 341 -ERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEE---EEKAKVEEQKRNKQLEEKK 396
Query: 594 QERLERKKRLEEIMKRTRRTEATDKKTSDQR--NGDIAKGALTGGTEVSA 641
E K + E++ ++ +KK + + + K GT+V A
Sbjct: 397 HAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQA 446
Score = 64.7 bits (156), Expect = 3e-10
Identities = 63/236 (26%), Positives = 112/236 (47%), Gaps = 24/236 (10%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER-TTRREEESRRLE 535
EE R+ E++R A E++ +E E+R EE +R K EE +R AEER R EEE +
Sbjct: 326 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE--KRAAEERQRARAEEEEKAKV 383
Query: 536 AEQAREKEEQLQRQAEERALREREEAE-----------RAQRQKEEEARVREEAE----R 580
EQ R K+ + ++ A + + E+ E +AQ K + A ++++ E +
Sbjct: 384 EEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTK 443
Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVS 640
V+ +REK +E++ ++++ +E +K+ + + K D++ G + G
Sbjct: 444 VQAKREK--LQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTH 501
Query: 641 ALPCTTNAPGNGKPVGSPHVVTSH-QSKVTVESTPDLEKQPNENGVSVQNENFEEI 695
L T N +P G V T + VE+ LE+ G ++E FE++
Sbjct: 502 KLKHTENT--FSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRG-ETESEEFEKL 554
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/227 (26%), Positives = 102/227 (44%), Gaps = 56/227 (24%)
Query: 447 PVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAR--------------- 491
P T A +S PS + + TT+ EE + E+ +
Sbjct: 123 PTITDASLSLPSRRMQNDTAENE---TTEKEEKSESRQERYEIEETETVTKSYQKNDWRD 179
Query: 492 -EQREKEERERREQEELERQKREELAQR----VAEERTTRREEES-------RRLEAEQA 539
E+ +KE++E+ E+EE E+ KR + + + EE+TT +EE+ ++ +E+
Sbjct: 180 AEENKKEDKEKEEEEE-EKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
Query: 540 REKEEQLQRQAE-------ERALREREEAERAQRQKEEEARVREEA------ERVR---- 582
+++EE+ Q E E +ER EAERA+ + EE R++ E ER R
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
Query: 583 -----QEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
QERE+ E + E +KR E +R + E K+ +++R
Sbjct: 299 EKAAAQERERREAEERERMREEEKRAAEERQRIKEEE---KRAAEER 342
Score = 60.1 bits (144), Expect = 7e-09
Identities = 48/139 (34%), Positives = 73/139 (52%), Gaps = 22/139 (15%)
Query: 465 ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERT 524
A ++ E R E+ R+ E E+R EE +R K EE +R AEER
Sbjct: 293 ARIEAEEKAAAQERERREAEERERMR-------EEEKRAAEERQRIKEEE--KRAAEERQ 343
Query: 525 TRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE 584
+EEE R E E+ R KEE+ +R AEER +RA+ ++EE+A+V E+ + E
Sbjct: 344 RIKEEEKRAAE-ERQRIKEEE-KRAAEER--------QRARAEEEEKAKVEEQKRNKQLE 393
Query: 585 REKHFQREEQ---ERLERK 600
+KH +E + E++E+K
Sbjct: 394 EKKHAMQETKIKGEKVEQK 412
Score = 55.1 bits (131), Expect = 2e-07
Identities = 81/395 (20%), Positives = 152/395 (38%), Gaps = 57/395 (14%)
Query: 373 KREVKVEPEKKDPEKEPQKVA-NEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAP 431
+ + KVE +K++ + E +K A E +KG K+E V E+ E ++ A
Sbjct: 378 EEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQG 437
Query: 432 APASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAR 491
A ++ T EE +K + +
Sbjct: 438 EEKGTKVQAKRE----------------------KLQEDKPTFKKEEIKDEKIKKDKEPK 475
Query: 492 EQREKEERERREQEELERQKREELAQRVAEERTT------RREEESRRLEAEQAREKEEQ 545
E+ + ++ E++ Q E + ++ T R +++ E E ++
Sbjct: 476 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535
Query: 546 LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERL-------- 597
L+ R E EE E+ +++++E A EE ++ R+ER K + EEQ R
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
Query: 598 ---ERKKRLEEIMKRTRRTEATDKKTSDQRNG--DIAKGALTGGTEVSALPCTTNAPGNG 652
E K+RL+E ++R RR EA +K+ +G D K + S+L A
Sbjct: 596 REEEEKRRLKEEIER-RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLN 654
Query: 653 KPV-GSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNENFEEIINLPIGSKPSRLDVTN 711
K V S V ++HQ+ + + + + E + I +KP++ ++
Sbjct: 655 KSVQKSSGVKSTHQAAIV-------------SKIDSRLEQYTSAIEGTKSAKPTKPAASD 701
Query: 712 SESPEIPLNPILAFDDEGTLGPLPQVDGVQTQQTA 746
P + I + ++G + P G ++TA
Sbjct: 702 LPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETA 736
Score = 53.1 bits (126), Expect = 9e-07
Identities = 65/247 (26%), Positives = 102/247 (41%), Gaps = 11/247 (4%)
Query: 463 ASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ-KREELAQRVAE 521
AS K + G E RL E+ R R + E EE E+ +Q++ E + EEL ++ E
Sbjct: 517 ASVDTKEAEGAPQVEAGKRL--EELRRRRGETESEEFEKLKQKQQEAALELEELKKKREE 574
Query: 522 ERTTRREEESRRLEAEQARE-KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
R EEE RR + E R+ +EE+ +R+ +E R R EA +RQK E + ++ +
Sbjct: 575 RRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAE-KRQKMPEDGLSDDKKP 633
Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVS 640
+ K + +ER E + + + T + + A+ G S
Sbjct: 634 FKCFTPKGSSLKIEERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEG--TKS 691
Query: 641 ALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNEN----GVSVQNENFEEII 696
A P A P + S K V S+P PN+ V V + E +
Sbjct: 692 AKPTKPAASDLPVPAEGVRNIKSMWEKGNVFSSPTAAGTPNKETAGLKVGVSSRINEWLT 751
Query: 697 NLPIGSK 703
P G+K
Sbjct: 752 KTPDGNK 758
Score = 52.4 bits (124), Expect = 2e-06
Identities = 56/208 (26%), Positives = 87/208 (41%), Gaps = 33/208 (15%)
Query: 497 EERERREQEELERQKREEL---AQRVAEERTTRREEESRRLEAEQAR-EKEEQLQRQAEE 552
++ ERR EL RQKREE+ A+R+A +R EEE+ R +AR E+ Q Q +
Sbjct: 2 DDFERRR--ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESL 59
Query: 553 RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK-KRLEEIMKRTR 611
+ ++ E +EEA+ +V + E F R ER+ KRL+E ++R +
Sbjct: 60 GQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQK 119
Query: 612 R-----TEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQS 666
T+A+ S + D A+ T E S S Q
Sbjct: 120 EFDPTITDASLSLPSRRMQNDTAENETTEKEEKS---------------------ESRQE 158
Query: 667 KVTVESTPDLEKQPNENGVSVQNENFEE 694
+ +E T + K +N EN +E
Sbjct: 159 RYEIEETETVTKSYQKNDWRDAEENKKE 186
Score = 51.2 bits (121), Expect = 3e-06
Identities = 36/93 (38%), Positives = 51/93 (54%), Gaps = 5/93 (5%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEERRRAAV 124
R+ RER E EK+ A E E+RA + ++ EE K+ EE QR KEE +RAA
Sbjct: 309 REAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA- 367
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKH 157
EE++R R EE++ +A V Q ++KH
Sbjct: 368 EERQRARAEEEE---KAKVEEQKRNKQLEEKKH 397
Score = 50.4 bits (119), Expect = 6e-06
Identities = 38/103 (36%), Positives = 56/103 (54%), Gaps = 9/103 (8%)
Query: 64 DDRQRLARERR---EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEE-QRQKEER 119
D+R R+ E + +ERE++ A E E+RA + ++ EE K+ EE QR KEE
Sbjct: 290 DERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEE 349
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPK---QKHNR 159
+RAA E+R++ EE+K E R E +K K QK N+
Sbjct: 350 KRAA--EERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNK 390
Score = 48.9 bits (115), Expect = 2e-05
Identities = 40/131 (30%), Positives = 61/131 (46%), Gaps = 16/131 (12%)
Query: 26 SYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAARE 85
++K++ +N SRP S G P + R R RR E E +
Sbjct: 500 THKLKHTENTFSRPGGRASVDTKEAEG-----APQVEAGKRLEELRRRRGETESEE---- 550
Query: 86 IVWLEREERARQHYEKHLEERKKRLEEQR---QKEERRRAAVEEKRRQRLEEDKER-HEA 141
E+ ++ +Q LEE KK+ EE+R ++EE+RR E R+ R EE+K R E
Sbjct: 551 ---FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEE 607
Query: 142 VVRRTMERSQK 152
+ RR E ++K
Sbjct: 608 IERRRAEAAEK 618
Score = 48.5 bits (114), Expect = 2e-05
Identities = 36/137 (26%), Positives = 68/137 (49%), Gaps = 9/137 (6%)
Query: 30 QDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERRE--EREKQLAAREIV 87
QDKK A R + + + R+ + ++ A E R+ + E++ AA E
Sbjct: 284 QDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQ 343
Query: 88 WLEREERARQHYEKHLEERKKRLEEQRQK---EERRRAAVEEKRRQRLEEDKERHEAVVR 144
++ EE+ + ++E +KR E+RQ+ EE +A VEE++R + E+K+ ++
Sbjct: 344 RIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH---AMQ 400
Query: 145 RTMERSQKPKQK-HNRW 160
T + +K +QK +W
Sbjct: 401 ETKIKGEKVEQKIEGKW 417
Score = 47.4 bits (111), Expect = 5e-05
Identities = 31/133 (23%), Positives = 59/133 (44%), Gaps = 2/133 (1%)
Query: 29 VQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVW 88
V++K S +S +N S +P + E+ EE +K+ A E
Sbjct: 212 VEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERAR 271
Query: 89 LEREERAR--QHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRT 146
LE EER R +K + + + R+E + + + R E + R+R+ E+++R +R
Sbjct: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRI 331
Query: 147 MERSQKPKQKHNR 159
E ++ ++ R
Sbjct: 332 KEEEKRAAEERQR 344
Score = 47.4 bits (111), Expect = 5e-05
Identities = 34/105 (32%), Positives = 58/105 (55%), Gaps = 10/105 (9%)
Query: 65 DRQRLARERRE----EREKQLA-AREIVWLEREERARQHYEKHLEERKKRLEEQ-RQKEE 118
+R RL E RE E++K++A R + E + A++ + EER++ EE+ R EE
Sbjct: 268 ERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKRAAEE 327
Query: 119 RRRAAVEEKR----RQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R+R EEKR RQR++E+++R +R E ++ ++ R
Sbjct: 328 RQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQR 372
Score = 45.4 bits (106), Expect = 2e-04
Identities = 49/177 (27%), Positives = 78/177 (44%), Gaps = 18/177 (10%)
Query: 461 VNASASVKTS-AGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRV 519
VNA SV A TT E L R R +E R++R QE LERQK +
Sbjct: 68 VNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITD 127
Query: 520 AEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE 579
A R ++ E E EKEE+ + + E + E E ++ ++ + R+ E
Sbjct: 128 ASLSLPSRRMQNDTAENETT-EKEEKSESRQERYEIEETETVTKSYQKNDW----RDAEE 182
Query: 580 RVRQEREKHFQREEQERLERKKR------LEEIMKRTRRTEATDKK-TSDQRNGDIA 629
++++EK E+E E+ KR E+M + TE+ ++ +NG I+
Sbjct: 183 NKKEDKEK-----EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQIS 234
Score = 41.6 bits (96), Expect = 0.003
Identities = 40/161 (24%), Positives = 72/161 (44%), Gaps = 14/161 (8%)
Query: 478 EATRLLAEKRRLAREQREKEE----RERREQEELERQKREELA------QRVAEERTTRR 527
E RL AE+ R ++EE R RR ++E RQK+EE + Q + +
Sbjct: 16 EEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVP 75
Query: 528 EEESRRLEAEQAREKEEQ---LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE 584
+EE++ E +++ L+R A R++ E +RQKE + + + + +
Sbjct: 76 DEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSR 135
Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
R ++ E E E++++ E +R E S Q+N
Sbjct: 136 RMQN-DTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175
Score = 40.0 bits (92), Expect = 0.008
Identities = 30/104 (28%), Positives = 55/104 (52%), Gaps = 8/104 (7%)
Query: 64 DDRQRLARERR--EEREKQLA-AREIVWLEREERAR---QHYEKHLEERKKRLEEQRQKE 117
++ +R A ER+ +E EK+ A R+ E EE+A+ Q K LEE+K ++E + K
Sbjct: 347 EEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKG 406
Query: 118 ERRRAAVEEK--RRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E+ +E K ++ +EDK + + ++ E+ K + K +
Sbjct: 407 EKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREK 450
Score = 39.7 bits (91), Expect = 0.010
Identities = 43/168 (25%), Positives = 71/168 (42%), Gaps = 45/168 (26%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEE---------LERQKREELAQRVAEERTT 525
D EEA R E+RR AR+ ER R++QEE +E + + A+ TT
Sbjct: 33 DEEEAAR---ERRRRARQ-----ERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTT 84
Query: 526 R----------------REEESRRLEAEQAREKEEQLQRQAEERAL------REREEAER 563
R EE R+ ++A E++++ + +L + + AE
Sbjct: 85 NTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAEN 144
Query: 564 AQRQKEEEARVR------EEAERVRQEREKHFQREEQERLERKKRLEE 605
+KEE++ R EE E V + +K+ R+ +E + K EE
Sbjct: 145 ETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEE 192
Score = 32.3 bits (72), Expect = 1.7
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 103 LEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
+++ ++R E +RQK E R E QR ++D+E A RR R ++ +QK S
Sbjct: 1 MDDFERRRELRRQKREEMRLEAERIAYQRNDDDEE-EAARERRRRARQERLRQKQEEESL 59
Query: 163 G 163
G
Sbjct: 60 G 60
Score = 32.0 bits (71), Expect = 2.2
Identities = 117/645 (18%), Positives = 220/645 (34%), Gaps = 131/645 (20%)
Query: 63 VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
+DD +R RR++RE+ R E R Y+++ ++ EE+ +E RRRA
Sbjct: 1 MDDFERRRELRRQKREEM----------RLEAERIAYQRNDDD-----EEEAARERRRRA 45
Query: 123 AVEEKRRQRLEE------------------DKER------------HEAVVRRTMERSQK 152
E R+++ EE D+E EA + R ++
Sbjct: 46 RQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREE 105
Query: 153 PKQKHNRWSWGGSLHGSPSIHSAD---PDRRSVSTMNLSKYVDPVISKRLSSSSATLLNS 209
+QK + + P+I A P RR + ++ + + +
Sbjct: 106 RRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEET 165
Query: 210 PDRARRLQLSPWESSVVNRL----------LTPTHSFLARSKSTAALSGEAASCSPIIMP 259
+ Q + W + N+ P + ++ + + +
Sbjct: 166 ETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVV 225
Query: 260 YKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNP 319
+ + S + PK +GS KER L + R +
Sbjct: 226 MSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQD 285
Query: 320 KARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVE 379
K R+R+ K+ AA + R + R + E +
Sbjct: 286 KKIADERARIEAEEKA--------------------AAQERERREAEERERMREEEKRAA 325
Query: 380 PEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAP 439
E++ ++E ++ A E R + + E+ EER + E AA A A
Sbjct: 326 EERQRIKEEEKRAAEE-----RQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEK 380
Query: 440 ASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKR----RLAREQRE 495
A V +A K + + + + EK+ +L +
Sbjct: 381 AK------VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLK 434
Query: 496 KEERERREQEELERQKREE-----LAQRVAEERTTRREEESRRLEAEQAREK-------- 542
K+ E+ + + +R+K +E + + +E+ + +E +++ R+K
Sbjct: 435 KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQ 494
Query: 543 -----------EEQLQRQAEERALREREEAE-----RAQRQKEEEARVREEAERVRQERE 586
E + RA + +EAE A ++ EE R R E E E+
Sbjct: 495 NGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKL 554
Query: 587 KHFQRE--------EQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
K Q+E +++R ER+K LEE +R R+ E D+K ++
Sbjct: 555 KQKQQEAALELEELKKKREERRKVLEEEEQR-RKQEEADRKLREE 598
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 81.3 bits (199), Expect = 3e-15
Identities = 90/361 (24%), Positives = 156/361 (43%), Gaps = 39/361 (10%)
Query: 278 PPEGSSRRRIIHGTASYKKERERENVLFLTSGTRRAVSPSNP----KARQPARSRLWLPS 333
PP+ + R+R S E + L R+ +PS+P K +P R+ L
Sbjct: 443 PPQSARRKRSYKQAVSELDEEQHLEDEELQPP--RSKTPSSPCPASKVVRPLRTFLHTVQ 500
Query: 334 KSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPE---KKDPEKEPQ 390
++ + T P S + + P ++ P R K E E ++ E++ +
Sbjct: 501 RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEEDKR 560
Query: 391 KVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPT 450
+ E LK L KV +A E + A +
Sbjct: 561 RRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ----------------IDE 604
Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEK-RRLAREQREKEER------ERRE 503
+ A K +A + EA R E+ RRL Q+E+EER ++++
Sbjct: 605 KTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKK 664
Query: 504 QEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE---E 560
+EE ER ++ A+R+AE+R R E+ RR + + +E+ EQ +R+ +ER L E+E E
Sbjct: 665 EEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQ-ERREQERQLAEQERRRE 723
Query: 561 AERAQRQK---EEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATD 617
ER Q ++ E E +R + E++++E E+ ++EEQ+RL ++ EE K+ +
Sbjct: 724 QERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 783
Query: 618 K 618
K
Sbjct: 784 K 784
Score = 78.6 bits (192), Expect = 2e-14
Identities = 65/186 (34%), Positives = 95/186 (51%), Gaps = 19/186 (10%)
Query: 477 EEATRLLAEKRRLAREQREKEERERRE----QEELERQKREELAQRVAEE--RTTRREEE 530
E+A + A K+ E R K+E E R Q+E E ++ +EL Q+ EE R+ E
Sbjct: 617 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE 676
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQ-RQKEEEARVRE----EAERVRQER 585
++RL ++ +E+ EQ +R+ E R RE+ R Q RQ E+ R RE +AER QER
Sbjct: 677 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736
Query: 586 EK--HFQREE-QERLERKKRLEEIMKRTRR--TEATDKKTSDQRNGDIAKGALTGGTEVS 640
EK Q+E+ Q LE KK+ EE + R E +KK + A AL +V
Sbjct: 737 EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAG---ASKALNVTVDVQ 793
Query: 641 ALPCTT 646
+ CT+
Sbjct: 794 SPACTS 799
Score = 77.4 bits (189), Expect = 4e-14
Identities = 51/155 (32%), Positives = 93/155 (60%), Gaps = 17/155 (10%)
Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR---LEAEQAR 540
A++ RLA E+ +K+ ++ +E R+K+EE A+R+ R ++EEE RR L ++
Sbjct: 609 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL---RWLQQEEEERRHQELLQKKKE 665
Query: 541 EKEEQLQRQAEERALRE-REEAERAQRQKEEEARVREEAERVRQEREKHF----QREEQE 595
E++E+L++ AE + L E RE+ R Q ++E+E R +E E+ R+E+E+ +R EQE
Sbjct: 666 EEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 725
Query: 596 RLERKKRLEE------IMKRTRRTEATDKKTSDQR 624
RL+ ++ L+E + K + E +KK +++
Sbjct: 726 RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 760
Score = 73.2 bits (178), Expect = 8e-13
Identities = 85/330 (25%), Positives = 144/330 (43%), Gaps = 52/330 (15%)
Query: 314 VSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVK 373
V+ + P+ + + W P TP P K A + PS G +
Sbjct: 385 VAAAEPEVPENNGNNSW-PHNDTEIANSTPNP---------KPAASSPETPSAG-----Q 429
Query: 374 REVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAP 433
+E K + + P + PQ + S K + E+ +E P++P P
Sbjct: 430 QEAKTD-QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPC----P 484
Query: 434 ASAPAPASAPAPAPVPTPAMVSAPSS---TVNASASVKTSAGTTDPEEATRLLAEKRR-- 488
AS V M+ P+S +V S + + DP+E R E R
Sbjct: 485 ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRK 544
Query: 489 -----LAREQREKEERERREQEELERQKR-------EELAQRVAEERTTRREEESRRLEA 536
L R++ E+++R R E+ +L+R++R E +++ EE+ + E++ +++
Sbjct: 545 EEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDE 604
Query: 537 EQAREKEEQLQRQAEER-----ALREREEAERAQRQKEEEARVR----EEAERVRQEREK 587
+ + KEE+L AEE+ A ++ EE E ++Q+EE R+R EE ER QE +
Sbjct: 605 KTEKAKEERL---AEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 661
Query: 588 HFQREEQERLER---KKRLEEIMKRTRRTE 614
+ EEQERL + KRL E ++ RR +
Sbjct: 662 KKKEEEQERLRKAAEAKRLAEQREQERREQ 691
Score = 71.2 bits (173), Expect = 3e-12
Identities = 53/168 (31%), Positives = 95/168 (56%), Gaps = 22/168 (13%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQ-EELERQKREELAQRVAE--ERTTRREEESRR 533
EE R E+ +L RE+R ++ + RE+ E+++ +K++++ Q+ A+ E+T + +EE R
Sbjct: 556 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE--R 613
Query: 534 LEAEQAREK-------EEQLQRQAEERALR---------EREEAERAQRQKEEE-ARVRE 576
L E+A++K E + +R+ EE A R ER E Q++KEEE R+R+
Sbjct: 614 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 673
Query: 577 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
AE R ++ +R EQER E+++R +E ++ RR + ++R
Sbjct: 674 AAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 721
Score = 69.3 bits (168), Expect = 1e-11
Identities = 49/159 (30%), Positives = 88/159 (55%), Gaps = 16/159 (10%)
Query: 478 EATRLLAEKRRLAREQR-----EKEERERREQEELERQKREELAQRVAEERTTRRE-EES 531
E + E+++ EQ+ EK E+ + E+ E+ K++ A+++ E R++ EE+
Sbjct: 582 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 641
Query: 532 RRL----EAEQAREKEEQLQRQAEE--RALREREEAERAQRQKEEEARVREEAERVRQER 585
RRL + E+ R +E LQ++ EE LR+ EA+R Q+E+E R +E E+ R+E+
Sbjct: 642 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 701
Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E R EQER E++++L E +R + ++ +R
Sbjct: 702 E----RREQERREQERQLAEQERRREQERLQAERELQER 736
Score = 57.4 bits (137), Expect = 5e-08
Identities = 139/638 (21%), Positives = 239/638 (37%), Gaps = 128/638 (20%)
Query: 84 REIVWLE--REERAR---QHYEKHLEERKKRLEEQRQKEERRRAAVEEKRR----QRLEE 134
+++VWLE +EE R + + K E K ++ ++++RR + V+++ R +RL
Sbjct: 29 KDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSR 88
Query: 135 DKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPV 194
K R + R + ++ GS+ + +A + +TM L+ P
Sbjct: 89 RKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAA---AAAAATMALAAPSSPT 145
Query: 195 ISKRLSSSSATLLNSP-DRARRLQLSP-------------------WESSVVNRLLTPTH 234
S L P D + QL P + + R L+PT
Sbjct: 146 -----PESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTP 200
Query: 235 SFLARSKSTAALSGEAASCSPIIMPYKA-AHSRNSMDRPKLFVTP--PEGSSRRRIIHGT 291
+ +TA S + P K+ A S+ L TP P+G GT
Sbjct: 201 A-----SATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGV-----GT 250
Query: 292 ASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPP 351
+ + + ++ G R SP+ P + P R R+ P LP TP S
Sbjct: 251 G---RSASKLRIAQVSPGPRD--SPAFPDS--PWRERVLAPI--LPDNFSTPTG-SRTDS 300
Query: 352 GSVKAAPAQVRPPSPGNIRPVKREVKVEPE---KKDPEKEPQKVANEPSLKGRA------ 402
SV+ +P PSP + K + + E ++ + +K A EP+ GR
Sbjct: 301 QSVRHSPIAPSSPSP-QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYL 359
Query: 403 -PLVKVE---EATVEERTPAEPEVGPAAPAMAPAPASA--------PAPASAPAPAPVPT 450
L+ VE + E++ P E E P A A P + + P P P
Sbjct: 360 ERLLNVEVPQKVGSEQKEPPE-EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELE-- 508
+ PS+ A + G +P ++ R KR + E +E + E EEL+
Sbjct: 419 ASSPETPSAG-QQEAKTDQADGPREPPQSAR---RKRSYKQAVSELDEEQHLEDEELQPP 474
Query: 509 --------------------------------------RQKREELAQRVAEERTTRREEE 530
R + +R R +E+E
Sbjct: 475 RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKE 534
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
+RLE + +E+ EQL+RQ E R R E + +R+ E +V + ERV Q +E+ +
Sbjct: 535 RQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE-ERLRKVLQARERVEQMKEEKKK 593
Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDI 628
+ EQ+ + ++ E+ + E KK + ++ ++
Sbjct: 594 QIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 631
Score = 50.1 bits (118), Expect = 8e-06
Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 23/117 (19%)
Query: 66 RQRLARERREE----REKQLAAREIVWLEREERARQHYE---KHLEERK---------KR 109
+++ A ++ EE R+++ AR + WL++EE R+H E K EE + KR
Sbjct: 620 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR 679
Query: 110 LEEQRQKEERRRAAVEEKRR-------QRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
L EQR++E R + E++RR +R E++++ E RR ER Q ++ R
Sbjct: 680 LAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/96 (30%), Positives = 55/96 (57%), Gaps = 7/96 (7%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA-- 122
+++R +ERRE+ ++ RE ER E+ RQ E+ ++RL+ +R+ +ER +A
Sbjct: 685 EQERREQERREQERREQERRE---QERREQERQLAEQERRREQERLQAERELQEREKALR 741
Query: 123 AVEEKRRQRLEEDKERHE--AVVRRTMERSQKPKQK 156
+E+ ++ LEE K++ E + R ++ Q+ K K
Sbjct: 742 LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
Score = 45.8 bits (107), Expect = 1e-04
Identities = 46/169 (27%), Positives = 76/169 (44%), Gaps = 52/169 (30%)
Query: 36 SSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREI--------- 86
+S P S + ++ + DP + +RQRL RR+E +QL +++
Sbjct: 509 TSAPRSVMKSFIKRNTPLRMDP----KEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLE 564
Query: 87 -VWLEREER------ARQHYEKHLEERKKRLEE---------QRQKEER----------- 119
V L+REER AR+ E+ EE+KK++E+ ++ KEER
Sbjct: 565 EVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 624
Query: 120 ---------RRAAVEEKRRQRL---EEDKERHEAVVRRTMERSQKPKQK 156
RR EE RR R EE++ RH+ ++++ E Q+ +K
Sbjct: 625 AKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 673
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/95 (27%), Positives = 52/95 (54%), Gaps = 12/95 (12%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERK---KRLEEQRQKEERRR 121
+ +RLA +R +ER +Q ER E+ R+ E+ +ER+ ++L EQ ++ E+ R
Sbjct: 676 EAKRLAEQREQERREQ---------ERREQERREQERREQERREQERQLAEQERRREQER 726
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
E + ++R + + + E + R E+ +K +Q+
Sbjct: 727 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/88 (27%), Positives = 48/88 (54%), Gaps = 2/88 (2%)
Query: 67 QRLARERREEREKQL--AAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
Q L ++++EE +++L AA E+ E+ R+ E+ +ER+++ ++++ E+ R
Sbjct: 657 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 716
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQK 152
E++RR+ E + E R R QK
Sbjct: 717 EQERRREQERLQAERELQEREKALRLQK 744
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 2/68 (2%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERA-RQHYEKHLEERKKRLEEQRQKEERR 120
R +RQ +ERR E+E+ A RE+ E+ R ++ ++ LEE+KK+ EEQ++ ER+
Sbjct: 709 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK-EEQQRLAERQ 767
Query: 121 RAAVEEKR 128
+EK+
Sbjct: 768 LQEEQEKK 775
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 80.9 bits (198), Expect = 4e-15
Identities = 58/151 (38%), Positives = 86/151 (56%), Gaps = 20/151 (13%)
Query: 473 TTDPEEATRLLAEKRRLAREQREKE---ERERREQEELERQKREELAQRVAEERTTRREE 529
TT E + L K R++R +++ R + ++ + +K ++ +R+AEER R EE
Sbjct: 734 TTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEE 793
Query: 530 ESRRLEAEQA----REKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQER 585
R+ + E+ REKEE+ QR+AEE+ L+EREE ERA+R K EE +RE ERV++
Sbjct: 794 RKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREE-ELREYQERVKK-- 850
Query: 586 EKHFQREEQERLERKKRLE--EIMKRTRRTE 614
E +ERKKR EI +R RR E
Sbjct: 851 --------LEEVERKKRQRELEIEERERRRE 873
Score = 62.4 bits (150), Expect = 1e-09
Identities = 48/134 (35%), Positives = 74/134 (55%), Gaps = 11/134 (8%)
Query: 495 EKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERA 554
E++E ER +LER+K E R++ R+ RL+A + EE+L +Q EER
Sbjct: 726 EQQEEERITTMQLEREKALEHKNRMSR-MLEDRDLFVMRLKAARQSVYEEKL-KQFEERL 783
Query: 555 LREREEA-ERAQRQKEEEARV-----REEAERVRQEREKHFQREEQERLERKKRLEEI-- 606
ER E +RQ++EE R+ +EE E+ R E + +REE+ER ER KR EE+
Sbjct: 784 AEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELRE 843
Query: 607 -MKRTRRTEATDKK 619
+R ++ E ++K
Sbjct: 844 YQERVKKLEEVERK 857
Score = 60.1 bits (144), Expect = 7e-09
Identities = 51/144 (35%), Positives = 80/144 (55%), Gaps = 19/144 (13%)
Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQ 545
+R LAR Q +E +ER E ++R+K EEL QR AE + R+ EE R + + REKE
Sbjct: 566 QRILARRQTIEERKERLESLNIQREK-EELEQREAELQKVRKAEEERLRQEAKEREKERI 624
Query: 546 LQ--RQAEERALREREEAER-----AQRQKEEEARVREE-------AERVRQ-EREKHFQ 590
LQ Q +++ +RER E + A+ K+ + EE A++V Q E+EK
Sbjct: 625 LQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEK--- 681
Query: 591 REEQERLERKKRLEEIMKRTRRTE 614
+E QERL+ +++ + +R +R E
Sbjct: 682 KELQERLKNQEKKIDYFERAKRLE 705
Score = 53.1 bits (126), Expect = 9e-07
Identities = 44/118 (37%), Positives = 64/118 (54%), Gaps = 16/118 (13%)
Query: 479 ATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQ 538
A + + E++ E+R EER R EE +RQ++EE +R+ R + EEE RR E +
Sbjct: 767 ARQSVYEEKLKQFEERLAEERHNR-LEERKRQRKEE--RRITYYRE-KEEEEQRRAEEQM 822
Query: 539 AREKE--EQLQRQAEERALRE-------REEAERAQRQKEEEARVREEAERVRQEREK 587
+E+E E+ +R E LRE EE ER +RQ+E E EE ER R+E +
Sbjct: 823 LKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEI---EERERRREEERR 877
Score = 51.6 bits (122), Expect = 3e-06
Identities = 39/118 (33%), Positives = 69/118 (58%), Gaps = 10/118 (8%)
Query: 508 ERQKREELAQRVAEERTTRREEE---SRRLEAEQAREKEEQLQRQAEERALREREEAERA 564
E++++ +LA A + +R+E + +RR E+ +E+ E L Q E+ L +R EAE
Sbjct: 545 EKEEQHQLAV-TAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQR-EAELQ 602
Query: 565 QRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSD 622
+ +K EE R+R+EA +EREK +E E++ +KK + E +++ ++TE K D
Sbjct: 603 KVRKAEEERLRQEA----KEREKERILQEHEQI-KKKTVRERLEQIKKTELGAKAFKD 655
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/155 (27%), Positives = 77/155 (49%), Gaps = 13/155 (8%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E RL KR+ E+R RE+ E+E+ R + + L +R ER R + E E
Sbjct: 786 ERHNRLEERKRQRKEERRITYYREKEEEEQ-RRAEEQMLKEREERERAERAKREEELREY 844
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARV------REEAERVRQEREKHFQ 590
++ +K E+++R+ +R L E E +R++EEE R+ R+++ ++ E ++
Sbjct: 845 QERVKKLEEVERKKRQREL----EIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWR 900
Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
+ + E ++ E K RR E D+ S +R+
Sbjct: 901 KGPEADSEWRRGPPE--KEWRRGEGRDEDRSHRRD 933
Score = 49.3 bits (116), Expect = 1e-05
Identities = 33/97 (34%), Positives = 52/97 (53%), Gaps = 13/97 (13%)
Query: 62 RVDDRQRLARERR-------EEREKQLAAREIVWLEREERARQHYEKHLEE------RKK 108
R+++R+R +E R +E E+Q A E + EREER R K EE R K
Sbjct: 790 RLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVK 849
Query: 109 RLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRR 145
+LEE +K+ +R +EE+ R+R EE + ++ R+
Sbjct: 850 KLEEVERKKRQRELEIEERERRREEERRLGDSSLSRK 886
Score = 45.1 bits (105), Expect = 2e-04
Identities = 49/177 (27%), Positives = 78/177 (44%), Gaps = 25/177 (14%)
Query: 451 PAMVSAPSSTVNASASVKTS--AGTTDPEEATRLLAEKR---RLAREQREKEERERREQE 505
P + S PS + + +S A + + +L EK +LA K R+ ++
Sbjct: 509 PHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRI 568
Query: 506 ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQ 565
RQ EE +R+ R +EE + RE E Q R+AEE LR
Sbjct: 569 LARRQTIEERKERLESLNIQREKEEL------EQREAELQKVRKAEEERLR--------- 613
Query: 566 RQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSD 622
+EA+ RE+ ER+ QE E+ ++ +ERLE+ K+ E K + + D + D
Sbjct: 614 ----QEAKEREK-ERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELD 665
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/97 (34%), Positives = 49/97 (50%), Gaps = 10/97 (10%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKE-ERRRAAVE 125
+RLA ER E++ R +EER +Y + EE ++R EEQ KE E R A
Sbjct: 781 ERLAEERHNRLEERKRQR------KEERRITYYREKEEEEQRRAEEQMLKEREERERAER 834
Query: 126 EKRRQRLEEDKER---HEAVVRRTMERSQKPKQKHNR 159
KR + L E +ER E V R+ +R + +++ R
Sbjct: 835 AKREEELREYQERVKKLEEVERKKRQRELEIEERERR 871
Score = 43.1 bits (100), Expect = 0.001
Identities = 36/152 (23%), Positives = 76/152 (50%), Gaps = 18/152 (11%)
Query: 484 AEKRRLAREQREKE-ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
AE+ RL +E +E+E ER +E E+++++ E +++ + + + +E + +
Sbjct: 607 AEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDP 666
Query: 543 EEQLQRQAEERALREREEAERAQRQKE-----EEARVREEAERVRQEREKH-------FQ 590
+ + +Q E+ ++E ER + Q++ E A+ EE ++ E+ ++
Sbjct: 667 DFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWE 726
Query: 591 REEQER-----LERKKRLEEIMKRTRRTEATD 617
++E+ER LER+K LE + +R E D
Sbjct: 727 QQEEERITTMQLEREKALEHKNRMSRMLEDRD 758
Score = 42.4 bits (98), Expect = 0.002
Identities = 36/149 (24%), Positives = 71/149 (47%), Gaps = 16/149 (10%)
Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQ 545
++ ARE+ RE R EE E + +E +R + EE+ + + E+ R++E
Sbjct: 1180 EKEKAREESWGPPRESRPSEEREWDREKE------RDRDNQDREENDK-DPERERDRERD 1232
Query: 546 LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQER-EKHFQREEQERLERKKRLE 604
+ R E+R R R+E + EE + R+ + R ++R ++ +R+++ L ++ L
Sbjct: 1233 VDR--EDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLR 1290
Query: 605 EIMK------RTRRTEATDKKTSDQRNGD 627
+ R+ R E + + +D R D
Sbjct: 1291 DDRDRRGPPLRSEREEVSSWRRADDRKDD 1319
Score = 41.2 bits (95), Expect = 0.004
Identities = 34/105 (32%), Positives = 52/105 (49%), Gaps = 11/105 (10%)
Query: 540 REKEEQLQRQAEERALREREEAER--AQRQKEEEARVREEAERVRQEREKHFQRE----- 592
+EKEEQ Q R+E +R A+RQ EE + R E+ +++E+E+ QRE
Sbjct: 544 QEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQK 603
Query: 593 ----EQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGAL 633
E+ERL ++ + E + + E KKT +R I K L
Sbjct: 604 VRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTEL 648
Score = 41.2 bits (95), Expect = 0.004
Identities = 27/94 (28%), Positives = 48/94 (51%), Gaps = 3/94 (3%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE---RRRA 122
RQ + E+ ++ E++LA LE +R R+ + R+K EEQR+ EE + R
Sbjct: 768 RQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKERE 827
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
E R + EE+ ++ V++ E +K +Q+
Sbjct: 828 ERERAERAKREEELREYQERVKKLEEVERKKRQR 861
Score = 40.4 bits (93), Expect = 0.006
Identities = 34/142 (23%), Positives = 61/142 (42%), Gaps = 11/142 (7%)
Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQ 545
+R A E + RR+ + + ++RE +R ER R++ RR ++ +E
Sbjct: 1249 RRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVS 1308
Query: 546 LQRQAEER---ALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKR 602
R+A++R + ER+ R R R+ E+EK R E++R
Sbjct: 1309 SWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDR------ 1362
Query: 603 LEEIMKRTRRTEATDKKTSDQR 624
E ++RT+ D T+ +R
Sbjct: 1363 --ESLRRTKNETDEDGWTTVRR 1382
Score = 40.0 bits (92), Expect = 0.008
Identities = 27/96 (28%), Positives = 52/96 (54%), Gaps = 9/96 (9%)
Query: 70 ARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK--EERRRAAVEEK 127
A E + + L R++ + + + YE+ L++ ++RL E+R EER+R EE+
Sbjct: 743 ALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEER 802
Query: 128 R----RQRLEEDKERHEAVV---RRTMERSQKPKQK 156
R R++ EE++ R E + R ER+++ K++
Sbjct: 803 RITYYREKEEEEQRRAEEQMLKEREERERAERAKRE 838
Score = 39.7 bits (91), Expect = 0.010
Identities = 29/91 (31%), Positives = 50/91 (54%), Gaps = 7/91 (7%)
Query: 73 RREEREKQLAAREIVWLEREERARQHYEKH-LEERKKRLEE---QRQKEERRRAAVEEKR 128
+ +E + QLA + R+E R + +EERK+RLE QR+KEE + E ++
Sbjct: 544 QEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQK 603
Query: 129 RQRLEEDKERHEAVVR---RTMERSQKPKQK 156
++ EE++ R EA R R ++ ++ K+K
Sbjct: 604 VRKAEEERLRQEAKEREKERILQEHEQIKKK 634
Score = 39.7 bits (91), Expect = 0.010
Identities = 27/78 (34%), Positives = 43/78 (55%), Gaps = 7/78 (8%)
Query: 82 AAREIVWLER----EERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKE 137
AAR+ V+ E+ EER + LEERK++ +E+R+ R EE+RR + KE
Sbjct: 766 AARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKE 825
Query: 138 RHEAVVRRTMERSQKPKQ 155
R E R ER+++ ++
Sbjct: 826 REE---RERAERAKREEE 840
Score = 38.5 bits (88), Expect = 0.023
Identities = 31/111 (27%), Positives = 53/111 (47%), Gaps = 9/111 (8%)
Query: 484 AEKRRLAREQ---REKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
+E+R RE+ R+ ++RE +++ + RE R R R E RR AE++
Sbjct: 1198 SEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESS 1257
Query: 541 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER----VRQEREK 587
+ +R +R R RE +R R E +R++ +R +R ERE+
Sbjct: 1258 SWRDSSRRDDRDRDDRRRERDDR--RDLRERRDLRDDRDRRGPPLRSEREE 1306
Score = 34.7 bits (78), Expect = 0.33
Identities = 27/94 (28%), Positives = 54/94 (57%), Gaps = 13/94 (13%)
Query: 62 RVDDRQRLARERR-EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ-KEER 119
R + ++ LAR + EER+++L + I Q ++ LE+R+ L++ R+ +EER
Sbjct: 562 RKEHQRILARRQTIEERKERLESLNI----------QREKEELEQREAELQKVRKAEEER 611
Query: 120 RRAAVEEKRRQR-LEEDKERHEAVVRRTMERSQK 152
R +E+ ++R L+E ++ + VR +E+ +K
Sbjct: 612 LRQEAKEREKERILQEHEQIKKKTVRERLEQIKK 645
Score = 34.7 bits (78), Expect = 0.33
Identities = 35/148 (23%), Positives = 59/148 (39%), Gaps = 19/148 (12%)
Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKE 543
A+ R+ R E + R ++ + L++R ++R RR ++SR
Sbjct: 1123 ADDDRIPRRGAEDDRGPWRNMDD------DRLSRRADDDRFPRRGDDSR----------P 1166
Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
+ + RE+E+A E+R EE E +REK R+ Q+R E K
Sbjct: 1167 GPWRPLVKPGGWREKEKAREESWGPPRESRPSEERE---WDREKERDRDNQDREENDKDP 1223
Query: 604 EEIMKRTRRTEATDKKTSDQRNGDIAKG 631
E R R + D+ + G +G
Sbjct: 1224 ERERDRERDVDREDRFRRPRDEGGWRRG 1251
Score = 30.4 bits (67), Expect = 6.3
Identities = 34/127 (26%), Positives = 54/127 (42%), Gaps = 17/127 (13%)
Query: 39 PASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREE----- 93
PA S ++ + D R D +R RERR+ R+ + + EREE
Sbjct: 1252 PAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWR 1311
Query: 94 RARQHYEKHLEERKK-------RLEEQRQKE-ERRRAAVEEKRRQRLEEDKERHEAVVRR 145
RA + +EER L R+++ +R R +EK R E+D+E +RR
Sbjct: 1312 RADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRES----LRR 1367
Query: 146 TMERSQK 152
T + +
Sbjct: 1368 TKNETDE 1374
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 80.5 bits (197), Expect = 5e-15
Identities = 56/167 (33%), Positives = 96/167 (57%), Gaps = 14/167 (8%)
Query: 465 ASVKTSAGTTDPEEATRLLAEK-RRLAREQREKEER------ERREQEELERQKREELAQ 517
A K +A + EA R E+ RRL Q+E+EER +++++EE ER ++ A+
Sbjct: 623 AKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAK 682
Query: 518 RVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE---EAERAQRQK---EEE 571
R+AE+R R E+ RR + + +E+ EQ +R+ +ER L E+E E ER Q ++ E E
Sbjct: 683 RLAEQREQERREQERREQERREQERREQ-ERREQERQLAEQERRREQERLQAERELQERE 741
Query: 572 ARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDK 618
+R + E++++E E+ ++EEQ+RL ++ EE K+ + K
Sbjct: 742 KALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASK 788
Score = 78.6 bits (192), Expect = 2e-14
Identities = 65/186 (34%), Positives = 95/186 (51%), Gaps = 19/186 (10%)
Query: 477 EEATRLLAEKRRLAREQREKEERERRE----QEELERQKREELAQRVAEE--RTTRREEE 530
E+A + A K+ E R K+E E R Q+E E ++ +EL Q+ EE R+ E
Sbjct: 621 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE 680
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQ-RQKEEEARVRE----EAERVRQER 585
++RL ++ +E+ EQ +R+ E R RE+ R Q RQ E+ R RE +AER QER
Sbjct: 681 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 740
Query: 586 EK--HFQREE-QERLERKKRLEEIMKRTRR--TEATDKKTSDQRNGDIAKGALTGGTEVS 640
EK Q+E+ Q LE KK+ EE + R E +KK + A AL +V
Sbjct: 741 EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAG---ASKALNVTVDVQ 797
Query: 641 ALPCTT 646
+ CT+
Sbjct: 798 SPACTS 803
Score = 77.4 bits (189), Expect = 4e-14
Identities = 51/155 (32%), Positives = 93/155 (60%), Gaps = 17/155 (10%)
Query: 484 AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR---LEAEQAR 540
A++ RLA E+ +K+ ++ +E R+K+EE A+R+ R ++EEE RR L ++
Sbjct: 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRL---RWLQQEEEERRHQELLQKKKE 669
Query: 541 EKEEQLQRQAEERALRE-REEAERAQRQKEEEARVREEAERVRQEREKHF----QREEQE 595
E++E+L++ AE + L E RE+ R Q ++E+E R +E E+ R+E+E+ +R EQE
Sbjct: 670 EEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQE 729
Query: 596 RLERKKRLEE------IMKRTRRTEATDKKTSDQR 624
RL+ ++ L+E + K + E +KK +++
Sbjct: 730 RLQAERELQEREKALRLQKEQLQRELEEKKKKEEQ 764
Score = 71.2 bits (173), Expect = 3e-12
Identities = 86/333 (25%), Positives = 135/333 (40%), Gaps = 51/333 (15%)
Query: 314 VSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVK 373
V+ + P+ + + W P TP P K A + PS G +
Sbjct: 385 VAAAEPEVPENNGNNSW-PHNDTEIANSTPNP---------KPAASSPETPSAG-----Q 429
Query: 374 REVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAP 433
+E K + + P + PQ + S K + E+ +E P++P P
Sbjct: 430 QEAKTD-QADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPC----P 484
Query: 434 ASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQ 493
AS V M+ P+S + T + EK R Q
Sbjct: 485 ASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKER----Q 540
Query: 494 REKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQ---- 549
R + R + E E+L RQK EE +R EE +REE R++ QARE+ EQ++ +
Sbjct: 541 RLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKV--LQARERVEQMKEEKKKQ 598
Query: 550 --------------AEERALREREEAERAQRQKEEEARVR----EEAERVRQEREKHFQR 591
A+E L E + ++A +K EE R EEA R+R +++ +R
Sbjct: 599 IEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEER 658
Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
QE L++KK EE +R R+ A K+ ++QR
Sbjct: 659 RHQELLQKKK--EEEQERLRKA-AEAKRLAEQR 688
Score = 71.2 bits (173), Expect = 3e-12
Identities = 53/168 (31%), Positives = 95/168 (56%), Gaps = 22/168 (13%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQ-EELERQKREELAQRVAE--ERTTRREEESRR 533
EE R E+ +L RE+R ++ + RE+ E+++ +K++++ Q+ A+ E+T + +EE R
Sbjct: 560 EEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE--R 617
Query: 534 LEAEQAREK-------EEQLQRQAEERALR---------EREEAERAQRQKEEE-ARVRE 576
L E+A++K E + +R+ EE A R ER E Q++KEEE R+R+
Sbjct: 618 LAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 677
Query: 577 EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
AE R ++ +R EQER E+++R +E ++ RR + ++R
Sbjct: 678 AAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 725
Score = 69.3 bits (168), Expect = 1e-11
Identities = 49/159 (30%), Positives = 88/159 (55%), Gaps = 16/159 (10%)
Query: 478 EATRLLAEKRRLAREQR-----EKEERERREQEELERQKREELAQRVAEERTTRRE-EES 531
E + E+++ EQ+ EK E+ + E+ E+ K++ A+++ E R++ EE+
Sbjct: 586 ERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEA 645
Query: 532 RRL----EAEQAREKEEQLQRQAEE--RALREREEAERAQRQKEEEARVREEAERVRQER 585
RRL + E+ R +E LQ++ EE LR+ EA+R Q+E+E R +E E+ R+E+
Sbjct: 646 RRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQ 705
Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E R EQER E++++L E +R + ++ +R
Sbjct: 706 E----RREQERREQERQLAEQERRREQERLQAERELQER 740
Score = 55.1 bits (131), Expect = 2e-07
Identities = 31/109 (28%), Positives = 61/109 (55%), Gaps = 2/109 (1%)
Query: 464 SASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER 523
+A K A + E + E+ R +E+RE+E RE ++ +L Q+R +R+ ER
Sbjct: 678 AAEAKRLAEQREQERREQERREQERREQERREQERRE--QERQLAEQERRREQERLQAER 735
Query: 524 TTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEA 572
+ E++ RL+ EQ + + E+ +++ E++ L ER+ E +++ +E A
Sbjct: 736 ELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAA 784
Score = 54.3 bits (129), Expect = 4e-07
Identities = 139/642 (21%), Positives = 241/642 (37%), Gaps = 132/642 (20%)
Query: 84 REIVWLE--REERAR---QHYEKHLEERKKRLEEQRQKEERRRAAVEEKRR----QRLEE 134
+++VWLE +EE R + + K E K ++ ++++RR + V+++ R +RL
Sbjct: 29 KDLVWLEEIQEEAERMFTREFSKEPELMPKTPSQKNRRKKRRISYVQDENRDPIRRRLSR 88
Query: 135 DKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPV 194
K R + R + ++ GS+ + +A + +TM L+ P
Sbjct: 89 RKSRSSQLSSRRLRSKDSVEKLATVVGENGSVLRRVTRAAA---AAAAATMALAAPSSPT 145
Query: 195 ISKRLSSSSATLLNSP-DRARRLQLSP-------------------WESSVVNRLLTPTH 234
S L P D + QL P + + R L+PT
Sbjct: 146 -----PESPTMLTKKPEDNHTQCQLVPVVEIGISERQNAEQHVTQLMSTEPLPRTLSPTP 200
Query: 235 SFLARSKSTAALSGEAASCSPIIMPYKA-AHSRNSMDRPKLFVTP--PEGSSRRRIIHGT 291
+ +TA S + P K+ A S+ L TP P+G GT
Sbjct: 201 A-----SATAPTSQGIPTSDEESTPKKSKARILESITVSSLMATPQDPKGQGV-----GT 250
Query: 292 ASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSLPP 351
+ + + ++ G R SP+ P + P R R+ P LP TP S
Sbjct: 251 G---RSASKLRIAQVSPGPRD--SPAFPDS--PWRERVLAPI--LPDNFSTPTG-SRTDS 300
Query: 352 GSVKAAPAQVRPPSPGNIRPVKREVKVEPE---KKDPEKEPQKVANEPSLKGRA------ 402
SV+ +P PSP + K + + E ++ + +K A EP+ GR
Sbjct: 301 QSVRHSPIAPSSPSP-QVLAQKYSLVAKQESVVRRASRRLAKKTAEEPAASGRIICHSYL 359
Query: 403 -PLVKVE---EATVEERTPAEPEVGPAAPAMAPAPASA--------PAPASAPAPAPVPT 450
L+ VE + E++ P E E P A A P + + P P P
Sbjct: 360 ERLLNVEVPQKVGSEQKEPPE-EAEPVAAAEPEVPENNGNNSWPHNDTEIANSTPNPKPA 418
Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELER- 509
+ PS+ A + G +P ++ R KR + E +E + E EEL+
Sbjct: 419 ASSPETPSAG-QQEAKTDQADGPREPPQSAR---RKRSYKQAVSELDEEQHLEDEELQPP 474
Query: 510 -------------------------QKREELAQRVAEERTTRR----------------- 527
Q+ + L + R+ +
Sbjct: 475 RSKTPSSPCPASKVVRPLRTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSF 534
Query: 528 -EEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQERE 586
E+E +RLE + +E+ EQL+RQ E R R E + +R+ E +V + ERV Q +E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKRE-ERLRKVLQARERVEQMKE 593
Query: 587 KHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDI 628
+ ++ EQ+ + ++ E+ + E KK + ++ ++
Sbjct: 594 EKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEV 635
Score = 50.1 bits (118), Expect = 8e-06
Identities = 36/117 (30%), Positives = 61/117 (52%), Gaps = 23/117 (19%)
Query: 66 RQRLARERREE----REKQLAAREIVWLEREERARQHYE---KHLEERK---------KR 109
+++ A ++ EE R+++ AR + WL++EE R+H E K EE + KR
Sbjct: 624 KKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKR 683
Query: 110 LEEQRQKEERRRAAVEEKRR-------QRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
L EQR++E R + E++RR +R E++++ E RR ER Q ++ R
Sbjct: 684 LAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 740
Score = 47.4 bits (111), Expect = 5e-05
Identities = 46/169 (27%), Positives = 75/169 (44%), Gaps = 48/169 (28%)
Query: 36 SSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREI--------- 86
+S P S + ++ + DP +RQRL RR+E +QL +++
Sbjct: 509 TSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLE 568
Query: 87 -VWLEREER------ARQHYEKHLEERKKRLEE---------QRQKEER----------- 119
V L+REER AR+ E+ EE+KK++E+ ++ KEER
Sbjct: 569 EVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAA 628
Query: 120 ---------RRAAVEEKRRQRL---EEDKERHEAVVRRTMERSQKPKQK 156
RR EE RR R EE++ RH+ ++++ E Q+ +K
Sbjct: 629 AKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRK 677
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/102 (28%), Positives = 59/102 (57%), Gaps = 4/102 (3%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA- 123
+++R +ERRE+ ++ RE ER E+ RQ E+ ++RL+ +R+ +ER +A
Sbjct: 689 EQERREQERREQERREQERRE---QERREQERQLAEQERRREQERLQAERELQEREKALR 745
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGS 165
+++++ QR E+K++ E R + Q+ ++K + + G S
Sbjct: 746 LQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGAS 787
Score = 43.1 bits (100), Expect = 0.001
Identities = 26/95 (27%), Positives = 52/95 (54%), Gaps = 12/95 (12%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERK---KRLEEQRQKEERRR 121
+ +RLA +R +ER +Q ER E+ R+ E+ +ER+ ++L EQ ++ E+ R
Sbjct: 680 EAKRLAEQREQERREQ---------ERREQERREQERREQERREQERQLAEQERRREQER 730
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
E + ++R + + + E + R E+ +K +Q+
Sbjct: 731 LQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
Score = 42.0 bits (97), Expect = 0.002
Identities = 24/88 (27%), Positives = 48/88 (54%), Gaps = 2/88 (2%)
Query: 67 QRLARERREEREKQL--AAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
Q L ++++EE +++L AA E+ E+ R+ E+ +ER+++ ++++ E+ R
Sbjct: 661 QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLA 720
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQK 152
E++RR+ E + E R R QK
Sbjct: 721 EQERRREQERLQAERELQEREKALRLQK 748
Score = 41.2 bits (95), Expect = 0.004
Identities = 25/68 (36%), Positives = 42/68 (61%), Gaps = 2/68 (2%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERA-RQHYEKHLEERKKRLEEQRQKEERR 120
R +RQ +ERR E+E+ A RE+ E+ R ++ ++ LEE+KK+ EEQ++ ER+
Sbjct: 713 REQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKK-EEQQRLAERQ 771
Query: 121 RAAVEEKR 128
+EK+
Sbjct: 772 LQEEQEKK 779
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 80.1 bits (196), Expect = 7e-15
Identities = 121/573 (21%), Positives = 234/573 (40%), Gaps = 48/573 (8%)
Query: 73 RREEREK--QLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
+ EE+ K + + +E V +E + Q E+ EE +K +E+ KEE EE+ +
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE---GGEEEEAE 495
Query: 131 RLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHG------SPSIHSADPDRRSVST 184
EE+ + A + E+ K K S + SP+ + +S +
Sbjct: 496 GGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK 555
Query: 185 MNLSKYVDPVISKRLSSSSATLLNSPDRAR----RLQLSPWESSVVNRLLTPT-HSFLAR 239
+ ++ + S + SP++A+ SP E+ + +P +
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615
Query: 240 SKSTAALSGEAASCSPIIMPYKA-AHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKER 298
+++ + + EA S + + P KA + ++ P+ +P + ++ E+
Sbjct: 616 AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAK----------SPEK 665
Query: 299 ERENVLFLTSGTRRAVSPSNPKARQP--ARSRLWLPSKSLPHLPGTPRPTSSLPPGSVKA 356
+ V +A SP +A+ P A+S + +KS P +P + P K+
Sbjct: 666 AKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKS-PEKAKSPVKEEAKSPEKAKS 724
Query: 357 APAQVRPPSPGNIR-PVKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEER 415
P + +P + PVK E K + K PEK P K A K E + ++
Sbjct: 725 -PVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPA---KEEARSPADK 780
Query: 416 TPAEPEVGPAAPAMAPAPASAPAPASAPAPAP-VPTPAMVSAPSSTVNASASVKTSAGTT 474
P + + +P A +P A AP +P V +P VK
Sbjct: 781 FPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPK 840
Query: 475 DPEE----ATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEE 530
EE AT EK+ +E+ K+E + + EE K+E ++ E + ++EE
Sbjct: 841 KAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE----KKEPAVEKPKESKVEAKKEE 896
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
+ + EKE + + +E A + +E+ E A+++ ++A+ +E ++ ++ +
Sbjct: 897 AEDKKKVPTPEKEAPAKVEVKEDA-KPKEKTEVAKKE-PDDAKAKEPSKPAEKKEAAPEK 954
Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
++ +E E+ K+ EE K + + DK S +
Sbjct: 955 KDTKE--EKAKKPEEKPKTEAKAKEDDKTLSKE 985
Score = 78.2 bits (191), Expect = 3e-14
Identities = 115/533 (21%), Positives = 201/533 (37%), Gaps = 42/533 (7%)
Query: 116 KEERRRAAVEEKRRQRL--EEDKERHEAVVRRTMERSQKPKQKHNRWSWGGS---LHGSP 170
K E + VE+ ++ + EE E + T E ++ K++ + GG G
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGE 498
Query: 171 SIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLL 230
+ P + S +K PV + S + A SP++ SP E +
Sbjct: 499 EETKSPPAEEAASPEKEAK--SPVKEEAKSPAEA---KSPEKEEAK--SPAEVKSPEKAK 551
Query: 231 TPT-HSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIH 289
+P + ++ + EA S + + P KA + +P E S +
Sbjct: 552 SPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK-----SPAEAKSPEK--- 603
Query: 290 GTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTSSL 349
S KE + + A SP+ K+ + A+S +KS P +P +
Sbjct: 604 -AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKS-PEKAKSPEKEEAK 661
Query: 350 PPGSVKAAPAQVRPPSPGNIR-PVKREVK--------VEPEKKDPEKEPQKVANEPSLKG 400
P K+ P + SP + PVK E K V+ E K PEK V E
Sbjct: 662 SPEKAKS-PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
Query: 401 RAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSST 460
+A EEA E+ + + +P A +P A A P +P+
Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK 780
Query: 461 VNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ-KREELAQRV 519
A PE+A L +E + E+E ++EE++ K EE Q V
Sbjct: 781 FPEKAKSPVKEEVKSPEKAKSPL-------KEDAKAPEKEIPKKEEVKSPVKEEEKPQEV 833
Query: 520 AEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAE 579
+ ++ EE + + EK++ + +A ++ + + E+ + E+ + EA+
Sbjct: 834 KVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAK 893
Query: 580 RVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGA 632
+ E +K E+E K ++E K +TE K+ D + + +K A
Sbjct: 894 KEEAEDKKKVPTPEKE-APAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPA 945
Score = 58.5 bits (140), Expect = 2e-08
Identities = 117/571 (20%), Positives = 209/571 (36%), Gaps = 48/571 (8%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR-LEEQRQKEERRRAA 123
+ ++ E EE EK+ A+E E E + E EE K EE E+ ++
Sbjct: 462 EETQVTEEVTEEEEKE--AKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP 519
Query: 124 VEEKRRQRLE-EDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSV 182
V+E+ + E + E+ EA ++ +K K + SP A
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVK 579
Query: 183 STMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSFLARSKS 242
S + S SP + + +S V +P + K+
Sbjct: 580 SPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAE-VKSPEKA 638
Query: 243 TAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKK-ERERE 301
+ EA S P K S ++ K V S + A K E+ +
Sbjct: 639 KSPTKEEAKSPEKAKSPEK--EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKS 696
Query: 302 NVLFLTSGTRRAVSP------SNPKARQPARSRLWLPSKSL---------PHLPGTPRPT 346
V +A SP S KA+ P + P K+ P +P
Sbjct: 697 PVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKA 756
Query: 347 SSLPPGSVKA-APAQVRPPSPGNIRPVKREVKVEPEKKDPEK--EPQKVANEPSLKGRAP 403
+L S +A PA+ SP + P K + V+ E K PEK P K + K
Sbjct: 757 KTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Query: 404 LVKVEEATVEERTPAEPEVGP----AAPAMAPA-PASAPAPASAPAPAP---VPTPAMVS 455
+V+ EE P E +V A APA P + S AP P P +
Sbjct: 817 KEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Query: 456 APSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREEL 515
V K A + E+ ++ ++ + KE+ + +E+ E+ +++ ++
Sbjct: 877 KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDD- 935
Query: 516 AQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVR 575
+ +E S+ E ++A +++ + EE+A + E+ + + KE++ +
Sbjct: 936 ---------AKAKEPSKPAEKKEAAPEKKDTK---EEKAKKPEEKPKTEAKAKEDDKTLS 983
Query: 576 EEAERVRQER-EKHFQREEQERLERKKRLEE 605
+E + + E+ EK ++++ +K E+
Sbjct: 984 KEPSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
Score = 41.2 bits (95), Expect = 0.004
Identities = 52/256 (20%), Positives = 97/256 (37%), Gaps = 25/256 (9%)
Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREK 496
P P S P P PS + + + + E ++ E++ Q +
Sbjct: 417 PIPFSLPEGLP-------KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQT-EETQVTE 468
Query: 497 EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALR 556
E E E+E E + +EE + EE EEE++ AE+A E++ + +E A
Sbjct: 469 EVTEEEEKEAKEEEGKEE--EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKS 526
Query: 557 -------EREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKR 609
E+EEA+ K E E + E +E+ + + + E K
Sbjct: 527 PAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKS 586
Query: 610 TRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVT 669
+ EA K ++ ++ + AK + E + P +P + V + ++K
Sbjct: 587 PAKEEA--KSPAEAKSPEKAKSPV---KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641
Query: 670 VE---STPDLEKQPNE 682
+ +P+ K P +
Sbjct: 642 TKEEAKSPEKAKSPEK 657
Score = 35.0 bits (79), Expect = 0.25
Identities = 36/178 (20%), Positives = 75/178 (42%), Gaps = 12/178 (6%)
Query: 18 VRSETAPDSYKVQDK-KNASSRPASAISGQNNNHSGNKPDPP----PVLRVDDRQRLARE 72
V+ E P KV++ K A A A K + P P +V++++ A E
Sbjct: 824 VKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVE 883
Query: 73 RREE------REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+ +E +E+ +++ E+E A+ ++ + ++K E +++ + +A
Sbjct: 884 KPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKT-EVAKKEPDDAKAKEPS 942
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVST 184
K ++ E E+ + + + +KPK + +L PS A+ +S ST
Sbjct: 943 KPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
Score = 34.7 bits (78), Expect = 0.33
Identities = 30/129 (23%), Positives = 57/129 (44%), Gaps = 28/129 (21%)
Query: 508 ERQKREELAQRVAE--ERTTRREEESRRLEAEQAREKEEQLQRQAE----ERALRER--- 558
E+++ + L R A ++ + E +R LE E A +++Q R A ER +RE
Sbjct: 97 EKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGA 156
Query: 559 -------------------EEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
E+ +++ ++EAR REEAE + + Q E R++
Sbjct: 157 VLRLGAARGQLRLEQEHLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDL 216
Query: 600 KKRLEEIMK 608
+K+ + + +
Sbjct: 217 QKKAQALQE 225
Score = 34.3 bits (77), Expect = 0.43
Identities = 36/115 (31%), Positives = 53/115 (46%), Gaps = 10/115 (8%)
Query: 487 RRLAREQREKE-ERERREQEELERQKREELAQRVAEER--TTRREEESR---RLEAEQAR 540
R+L R E E Q++ R EL +R E R +R RLE E
Sbjct: 116 RQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAARGQLRLEQEHLL 175
Query: 541 EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
E ++++ ++ A R+REEAE A R AR +EAE R + +K Q ++E
Sbjct: 176 EDIAHVRQRLDDEA-RQREEAEAAARAL---ARFAQEAEAARVDLQKKAQALQEE 226
Score = 33.5 bits (75), Expect = 0.74
Identities = 45/176 (25%), Positives = 70/176 (39%), Gaps = 40/176 (22%)
Query: 486 KRRLAREQREKEERE-----------RREQEELERQKREELAQRVAEERTTRREEESRRL 534
++RL E R++EE E E ++ QK+ + Q +EE L
Sbjct: 182 RQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEEVGEL 241
Query: 535 EAEQAREKEEQLQRQAEER---------ALRE---------------REEAERAQRQK-E 569
+ Q Q QAE R ALRE EE R + +
Sbjct: 242 LGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLS 301
Query: 570 EEARVREEAERVRQEREKHFQREEQER---LERKKRLEEIMKRTRRTEATDKKTSD 622
E A+V +A R QE ++R+ Q R LE K ++ ++R +R+E D+ +D
Sbjct: 302 EAAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLER-QRSELEDRHQAD 356
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 79.7 bits (195), Expect = 9e-15
Identities = 50/145 (34%), Positives = 77/145 (53%), Gaps = 9/145 (6%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
E+RR+ R ++ER R E ER + E R E R E+ R LE E+ARE+E
Sbjct: 661 EERRVDRVDDRRDERARERDRERERDRERE---RERERERDREREKERELERERARERER 717
Query: 545 QLQRQAEERALRERE-----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
+ +++ + R+R+ E ER + +++E R REE ER R ERE+ +RE + ER
Sbjct: 718 EREKERDRERDRDRDHDRERERERERDREKEREREREERERER-ERERERERERERERER 776
Query: 600 KKRLEEIMKRTRRTEATDKKTSDQR 624
+ ++ +R R E DK D+R
Sbjct: 777 ARERDKERERQRDWEDKDKGRDDRR 801
Score = 77.4 bits (189), Expect = 4e-14
Identities = 49/154 (31%), Positives = 83/154 (53%), Gaps = 7/154 (4%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
+E R +R RE+ + ERER + E ER+ E A+ ER R+ E R +
Sbjct: 673 DERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDR-DR 731
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE-EAERVRQ-----EREKHFQ 590
+ RE+E + +R E+ REREE ER + ++ E R RE E ER R+ ER++ ++
Sbjct: 732 DHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDWE 791
Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+++ R +R+++ EEI + + D++ S +R
Sbjct: 792 DKDKGRDDRREKREEIREDRNPRDGHDERKSKKR 825
Score = 60.1 bits (144), Expect = 7e-09
Identities = 43/142 (30%), Positives = 66/142 (46%), Gaps = 9/142 (6%)
Query: 478 EATRLLAEKRRLAREQREKEERER-----REQEELERQKREELAQRVAEERTTRREEESR 532
E R A +R RE+ ER+R RE+E + RE+ +R EER RE E
Sbjct: 706 ELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERE 765
Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
R E E+ RE+E +R E R+ E+ ++ + + E+ REE R R+ H +R+
Sbjct: 766 R-ERERERERERARERDKERERQRDWEDKDKGRDDRREK---REEIREDRNPRDGHDERK 821
Query: 593 EQERLERKKRLEEIMKRTRRTE 614
++R + RR E
Sbjct: 822 SKKRYRNEGSPSPRQSPKRRRE 843
Score = 58.9 bits (141), Expect = 2e-08
Identities = 131/606 (21%), Positives = 219/606 (36%), Gaps = 86/606 (14%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R DR+R RER +REK+ ER R+ E+ E ++R E+ ++ ER R
Sbjct: 731 RDHDRER-ERERERDREKE-----------REREREERERERERERERERERERERERAR 778
Query: 122 AAVEEKRRQRLEEDKER---HEAVVRRTMERSQKPKQKHNRWSWGGSL--HGSPS----- 171
+E+ RQR EDK++ R + + P+ H+ GSPS
Sbjct: 779 ERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSP 838
Query: 172 ----IHSADPDR------RSVSTMNLSKYVDPVISKRLSSSSATLLNS---PDRARRLQL 218
HS D D ++ LS+ V P S+ LS S T + R+ +
Sbjct: 839 KRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPER 898
Query: 219 SPWESSVVNRLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTP 278
+ L S + + + + + + I+ + + R + DR
Sbjct: 899 KESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDR-----AH 953
Query: 279 PEGSSRRRIIHGTASYKKER----ERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSK 334
E + +I KKE ER N+ TS + SP + + K
Sbjct: 954 DENKKKAKIQKKPIKKKKEDDVGIERGNI-ETTSEDGQVFSPKKGQKK-----------K 1001
Query: 335 SLPHLPGTPRPTSSLPPGSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEKEPQKVAN 394
S+ + S + + R P I + V++ K ++ QK
Sbjct: 1002 SIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEELVEMCNGKNGILEDSQK--- 1058
Query: 395 EPSLKGRAPLVKVEEATVEERTPAEPEVGPAA-PAMAPAPASAPAPASA--PAPAPVPTP 451
K + V +RT EV A A A P S P+P S+ P P PV T
Sbjct: 1059 ----KEDTAFSDWSDEDVPDRT----EVTEAEHTATATTPGSTPSPLSSLLPPPPPVATA 1110
Query: 452 AMVSAPSSTVNASASVKTSAGT---TDPEEATRLLAEKRRLAREQREKE-ERERREQEEL 507
+ P++ +A+ TS T T AT A E ++ R R E+ E
Sbjct: 1111 TATTVPATLAATTAAAATSFSTSAITISTSATPTNTTNNTFANEDSHRKCHRTRVEKVET 1170
Query: 508 ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE--QLQRQAEERALREREEAERAQ 565
E+ A+ R ++ S L + ++ +L+ + + A R ++ +
Sbjct: 1171 PHVTIED-----AQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRK 1225
Query: 566 RQKEEEARVREEAERV-----RQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKT 620
R +R RE+ + + R+ R +R E R R + +RR+ +
Sbjct: 1226 RVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQ 1285
Query: 621 SDQRNG 626
R+G
Sbjct: 1286 VHSRSG 1291
Score = 50.4 bits (119), Expect = 6e-06
Identities = 43/177 (24%), Positives = 82/177 (46%), Gaps = 11/177 (6%)
Query: 470 SAGTTDPEEATRLLAEKRRLAREQREKEER----ERREQEELERQKREELAQRVAEERTT 525
S T+ + +R + +R R+ R + R++ + ER + E +R E R T
Sbjct: 1260 SRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQ-ERDRYEHDRERERERRDT 1318
Query: 526 RREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR-QE 584
R+ E R + + R ++ R+ E RERE +R +E E + + ER R ++
Sbjct: 1319 RQREWDRDADKDWPRNRDRDRLRERE----RERERDKRRDLDRERERLISDSVERDRDRD 1374
Query: 585 REKHFQREEQERLER-KKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVS 640
R++ F+ + E ++R + +LE +R + + D D+ D G++ G E +
Sbjct: 1375 RDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETN 1431
Score = 50.1 bits (118), Expect = 8e-06
Identities = 42/160 (26%), Positives = 61/160 (38%), Gaps = 30/160 (18%)
Query: 30 QDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVD-------------DRQR---LARER 73
+D + RP+S I Q N + + RVD DR+R RER
Sbjct: 632 RDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERER 691
Query: 74 REEREKQLAAREIVWLERE-------------ERARQHYEKHLEERKKRLEEQRQKEERR 120
ERE+ + LERE +R R H ER++ E R+KE R
Sbjct: 692 ERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERER 751
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
E+ R+R E ++ER R K +++ W
Sbjct: 752 EREERERERER-ERERERERERERERARERDKERERQRDW 790
Score = 48.5 bits (114), Expect = 2e-05
Identities = 35/125 (28%), Positives = 53/125 (42%), Gaps = 1/125 (0%)
Query: 491 REQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQA 550
R+Q ERR E R RE + + R R +E R E + R + R+
Sbjct: 614 RDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRD 673
Query: 551 EERALREREEAERAQRQKEEEARVREEAERVRQ-EREKHFQREEQERLERKKRLEEIMKR 609
E R+RE +R++E E E E+ R+ ERE+ +RE + ER + +
Sbjct: 674 ERARERDRERERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDH 733
Query: 610 TRRTE 614
R E
Sbjct: 734 DRERE 738
Score = 48.1 bits (113), Expect = 3e-05
Identities = 37/133 (27%), Positives = 64/133 (48%), Gaps = 5/133 (3%)
Query: 498 ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRE 557
ER+R + + Q R+ +R ER R E + + R + + + +ER RE
Sbjct: 604 ERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDER--RE 661
Query: 558 REEAERAQRQKEEEARVRE-EAERVRQ-EREKHFQREEQERLERKKRLEEIMKRTR-RTE 614
+R +++E AR R+ E ER R+ ERE+ +R+ + ER+ E +R R R +
Sbjct: 662 ERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREK 721
Query: 615 ATDKKTSDQRNGD 627
D++ R+ D
Sbjct: 722 ERDRERDRDRDHD 734
Score = 47.0 bits (110), Expect = 6e-05
Identities = 78/400 (19%), Positives = 141/400 (35%), Gaps = 28/400 (7%)
Query: 311 RRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPT-SSLPPGSVKAAPAQVRPPSPGNI 369
R+ + S+P Q S+ K P P P P + G +V+
Sbjct: 235 RKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKT 294
Query: 370 RPVK---REVKVEPEKKDPEKEPQKVA----------NEPSLKGRAPLVKVEEATVEERT 416
R K R+ + + EK+D + + S + + + + + +RT
Sbjct: 295 RDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRT 354
Query: 417 PAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDP 476
P+ P + + + P+ S +P +P +P +TS
Sbjct: 355 PSPSYQRTLTPPLRRSASPYPSH-SLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHDRR 413
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E KR REK+ RE RE E+ + R+ R + RR+ R
Sbjct: 414 HERREDTRGKR-----DREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARDTRDRR 468
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQER 596
E ++ + R+ + + +E + + +A + E R++ EE
Sbjct: 469 ELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRS 528
Query: 597 LERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKPVG 656
R EE + R E+ ++ S+ RN + + V LP + G +
Sbjct: 529 YGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSR----GRVPELPEKGSRGSRGSQID 584
Query: 657 SPHVVTS--HQSKVTVESTPDLEKQP-NENGVSVQNENFE 693
S H S H S T S P+ ++ P +N ++ +FE
Sbjct: 585 S-HSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFE 623
Score = 43.9 bits (102), Expect = 5e-04
Identities = 36/167 (21%), Positives = 74/167 (44%), Gaps = 7/167 (4%)
Query: 455 SAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREE 514
S+ S+ + V + +G+ D + L E+ R ++ + ER Q E +R ++
Sbjct: 1274 SSRRSSPESDRQVHSRSGSFDSRDR---LQERDRYEHDRERERERRDTRQREWDRDADKD 1330
Query: 515 LAQRVAEERTTRREEESRRLEAEQA-REKEEQLQRQAEERALRERE---EAERAQRQKEE 570
+ +R RE E R + RE+E + E R+R+ E+ + + K
Sbjct: 1331 WPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRC 1390
Query: 571 EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATD 617
EA++ E ER + + ++ER+++ + + T ++E T+
Sbjct: 1391 EAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTE 1437
Score = 43.5 bits (101), Expect = 7e-04
Identities = 57/280 (20%), Positives = 111/280 (39%), Gaps = 46/280 (16%)
Query: 370 RPVKREVKVEPEK---KDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAA 426
R +RE + E E+ +D E+E Q+ + KGR + E E+R P + +
Sbjct: 764 RERERERERERERARERDKERERQRDWEDKD-KGRDDRREKREEIREDRNPRDGHDERKS 822
Query: 427 PAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEK 486
S P+P P +P S S D E RLL++
Sbjct: 823 KKRYRNEGS-------PSPRQSPKRRREHSPDSDAYNSGD--------DKNEKHRLLSQ- 866
Query: 487 RRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQL 546
+ R Q + E+ + + +EE +R R+E SRR E ++ +EK +
Sbjct: 867 --VVRPQESRSLSPSHLTEDRQGRWKEE-------DRKPERKESSRRYEEQELKEKVSSV 917
Query: 547 QRQAEERALRE-----------------REEAERAQRQKEEEARVREEAERVRQEREKHF 589
+Q E+ + E RE ++RA + +++A+++++ + ++E +
Sbjct: 918 DKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGI 977
Query: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIA 629
+R E ++ K ++ K+ + + DI+
Sbjct: 978 ERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKSKGDSDIS 1017
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/137 (24%), Positives = 64/137 (46%), Gaps = 16/137 (11%)
Query: 491 REQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR---------E 541
RE+ + E + +++ KR E ++ + +R R SRR E R +
Sbjct: 1235 REKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFD 1294
Query: 542 KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR-----QEREKHFQREEQER 596
++LQ + RERE R RQ+E + ++ R R +ERE+ +R+++
Sbjct: 1295 SRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERERERERDKRRD 1354
Query: 597 L--ERKKRLEEIMKRTR 611
L ER++ + + ++R R
Sbjct: 1355 LDRERERLISDSVERDR 1371
Score = 41.2 bits (95), Expect = 0.004
Identities = 37/140 (26%), Positives = 65/140 (46%), Gaps = 24/140 (17%)
Query: 19 RSETAPDS--YKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREE 76
R E +PDS Y D KN R S + + S + P +DRQ R + E+
Sbjct: 841 RREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLS-----PSHLTEDRQ--GRWKEED 893
Query: 77 REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDK 136
R+ ER+E +R++ E+ L+E+ +++QR++ E + E R R ++
Sbjct: 894 RKP----------ERKESSRRYEEQELKEKVSSVDKQREQTE-----ILESSRMRAQDII 938
Query: 137 ERHEAVVRRTMERSQKPKQK 156
H++ R T +R+ +K
Sbjct: 939 GHHQSEDRETSDRAHDENKK 958
Score = 38.1 bits (87), Expect = 0.030
Identities = 25/128 (19%), Positives = 55/128 (42%), Gaps = 6/128 (4%)
Query: 498 ERERREQEEL--ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERAL 555
+RE+ + E+ ER+ R + +R R+T + + R + + E Q + +
Sbjct: 1234 DREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSF 1293
Query: 556 REREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
R+ + R + + R RE R R++ + R+ + R + + + +R R E
Sbjct: 1294 DSRDRLQERDRYEHDRERERER----RDTRQREWDRDADKDWPRNRDRDRLRERERERER 1349
Query: 616 TDKKTSDQ 623
++ D+
Sbjct: 1350 DKRRDLDR 1357
Score = 36.6 bits (83), Expect = 0.088
Identities = 34/124 (27%), Positives = 62/124 (50%), Gaps = 10/124 (8%)
Query: 30 QDKKNASSRPASAISG-QNNNHSGNKPDPPPVLRVDDRQRLARERREEREKQLAAREIVW 88
QD ++ SSR +S S Q ++ SG+ R+ +R R +R ERE+ R+
Sbjct: 1268 QDSRSHSSRRSSPESDRQVHSRSGSFDSRD---RLQERDRYEHDRERERER----RDTRQ 1320
Query: 89 LEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVR-RTM 147
E + A + + ++ +R + E +R++E +R ++ +R + + + ER R RT
Sbjct: 1321 REWDRDADKDWPRN-RDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTF 1379
Query: 148 ERSQ 151
E SQ
Sbjct: 1380 ESSQ 1383
Score = 36.2 bits (82), Expect = 0.11
Identities = 25/94 (26%), Positives = 44/94 (46%), Gaps = 3/94 (3%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R D R +R E ++Q+ +R + R+ + +H ER++ + RQ+E R
Sbjct: 1267 RQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRD 1326
Query: 122 AAVEEKR---RQRLEEDKERHEAVVRRTMERSQK 152
A + R R RL E + E RR ++R ++
Sbjct: 1327 ADKDWPRNRDRDRLRERERERERDKRRDLDRERE 1360
Score = 34.7 bits (78), Expect = 0.33
Identities = 36/146 (24%), Positives = 60/146 (41%), Gaps = 16/146 (10%)
Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
PE T L E+ + R+ + E ++R +E ++E R RE+E ++
Sbjct: 78 PERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKES-------SRGRHREKEDIKIT 130
Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
E+ E EE+ E R+ + E + E RQ+ ++ + EQE
Sbjct: 131 KERTPESEEE---NVEWETNRDDSDNGDINYDYVHELSL----EMKRQKIQRELMKLEQE 183
Query: 596 RLERKKRLEEIMKRTRRTEATDKKTS 621
+E KR E I+K+ E K S
Sbjct: 184 NME--KREEIIIKKEVSPEVVRSKLS 207
Score = 32.0 bits (71), Expect = 2.2
Identities = 28/100 (28%), Positives = 49/100 (49%), Gaps = 16/100 (16%)
Query: 71 RERREEREKQLAAREIVWLER--EERARQHYEK--------HLEERKKRLEEQRQKEERR 120
R+R ER+ + AR+ + R E R + E+ + R LE ++EERR
Sbjct: 605 RDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERR 664
Query: 121 RAAVEEKRRQRL-EEDKERHEAVVRRTMERSQKPKQKHNR 159
V+++R +R E D+ER R ER ++ +++ +R
Sbjct: 665 VDRVDDRRDERARERDRER-----ERDRERERERERERDR 699
Score = 31.2 bits (69), Expect = 3.7
Identities = 38/195 (19%), Positives = 79/195 (40%), Gaps = 12/195 (6%)
Query: 18 VRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERREER 77
VRS+ +P + K+ + + S + P+L D+QR ++ + ++
Sbjct: 202 VRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLL---DQQRNSKTNQSKK 258
Query: 78 EKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKE 137
+ + + + Y++ + + + E+ R ++R R + RQR + DK
Sbjct: 259 KGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGR----DFERQREKRDKP 314
Query: 138 RHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTMNLSKYVDPVISK 197
R + + S + H+ S GS S HS P R+ + + + + P + +
Sbjct: 315 RSTSPAGQ--HHSPISSRHHSSSSQSGS---SIQRHSPSPRRKRTPSPSYQRTLTPPLRR 369
Query: 198 RLSSSSATLLNSPDR 212
S + L+SP R
Sbjct: 370 SASPYPSHSLSSPQR 384
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 79.3 bits (194), Expect = 1e-14
Identities = 77/312 (24%), Positives = 132/312 (42%), Gaps = 38/312 (12%)
Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ 510
P PSS VN ++ + E+ R Q+ +E++ REQEE +RQ
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENK---ERSEALRRQQLLQEQQLREQEEYKRQ 390
Query: 511 KREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE 570
E +R+ +++ RR E ++ +AR ++E+ QR+ E+ R EE ER R+KEE
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELER--RRKEE 448
Query: 571 EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
E R R E E+ R ERE+ + R + E E ++ LE + ++ + +A D R
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLE--EEQRHLEVLQQQLLQEQA--MLLHDHRRPH--- 501
Query: 631 GALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQPNENGVSVQNE 690
+ S P + +P ++ D ++ N + Q++
Sbjct: 502 ------PQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEAQSK 555
Query: 691 NFEEIINLPIGSKPSRLDVTNSES----------PEIPL-----NPILAFDDEGTLGPLP 735
++ P+ S+ NSES P++P+ +P+L+ D PL
Sbjct: 556 QTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPVRTTSRSPVLSRRD----SPL- 610
Query: 736 QVDGVQTQQTAE 747
Q G Q Q +
Sbjct: 611 QGSGQQNSQAGQ 622
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/155 (32%), Positives = 82/155 (52%), Gaps = 21/155 (13%)
Query: 488 RLAREQREKEERE------RREQEELERQKREELA-QRVAEERTTRREEESRRLEAEQAR 540
R +++ EK+E E E+EE+ Q+ E + V E T RR+ RL+ E +
Sbjct: 308 RTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD--FLRLQQEN-K 364
Query: 541 EKEEQLQRQA--EERALREREE------AERAQR---QKEEEARVREEAERVRQEREKHF 589
E+ E L+RQ +E+ LRE+EE AER +R QKE+ R+ E+ R R+ R +
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+ + + E K+RLEE+ +R + E + ++R
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/91 (38%), Positives = 54/91 (59%), Gaps = 6/91 (6%)
Query: 66 RQRLA-RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
RQ LA R++R E++K+ R RE AR+ E+ E+R++ EE+R+ EE R
Sbjct: 389 RQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQER--EQRRREQEEKRRLEELERRRK 446
Query: 125 EEKRRQRLEEDK---ERHEAVVRRTMERSQK 152
EE+ R+R EE+K ER + +RR +E Q+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Score = 52.4 bits (124), Expect = 2e-06
Identities = 91/374 (24%), Positives = 148/374 (39%), Gaps = 79/374 (21%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKH----LEERKKRLEEQRQ-KEE 118
+ R+RL ++R ERE A R+ ERE+R R+ EK LE R+K EE+R+ +EE
Sbjct: 404 EQRRRLEEQQRRERE---ARRQ---QEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ--------KPKQKHNRWSWGGSLHGS- 169
+RR E++ +R E+++RH V+++ + + Q +P +H++ S
Sbjct: 458 KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK 517
Query: 170 PSIHSADPDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWE--SSVVN 227
PS H+ +P + +P R DR R+ S E S
Sbjct: 518 PSFHAPEP----------KAHYEPADRAR---------EVEDRFRKTNHSSPEAQSKQTG 558
Query: 228 RLLTPTHSFLARSKSTAALSGEAASCSPIIMPYKAAHSRNSMDRPKLFVTPPEGSSRRRI 287
R+L P S+S + +G + S P ++ RP P +SR +
Sbjct: 559 RVLEPP----VPSRSESFSNGNSESVHP------------ALQRPAEPQVPVRTTSRSPV 602
Query: 288 IHGTASYKKERERENVLFLTSGTRRAVSPSNPKARQPARSRLWLPSKSLPHLPGTPRPTS 347
+ S + ++N +G R + S P+ LW + L PG+ +
Sbjct: 603 LSRRDSPLQGSGQQN---SQAGQRNSTSSIEPRL-------LWERVEKLVPRPGSGSSSG 652
Query: 348 SLPPGSVKAAPA----------QVRPPSPGNIRPVKR--EVKVEPEKKDPEKEPQKVANE 395
S GS + +VR S P +R +PE K P K A E
Sbjct: 653 SSNSGSQPGSHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRPLKPAGE 712
Query: 396 PSLKGRAPLVKVEE 409
L A ++ E
Sbjct: 713 VDLTALAKELRAVE 726
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/113 (28%), Positives = 60/113 (53%), Gaps = 9/113 (7%)
Query: 56 DPPPVLRVDDRQRLARE----RREEREKQLAAREIVWLEREE-RARQHYEKHL-EERKKR 109
+P ++ V L R+ ++E +E+ A R L+ ++ R ++ Y++ L ER+KR
Sbjct: 339 EPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398
Query: 110 LE---EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+E EQR++ E ++ E RRQ+ E + R + RR E ++ K++ R
Sbjct: 399 IEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 8/100 (8%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQ-------HYEKHLEERKKRLEEQRQKEER 119
Q+ +ER E +Q +E E+EE RQ E+ E+R++ E+QR++ E
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
RR E+RR R +E+K R E + RR E ++ + + +
Sbjct: 420 RRQQEREQRR-REQEEKRRLEELERRRKEEEERRRAEEEK 458
Score = 35.0 bits (79), Expect = 0.25
Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 27/135 (20%)
Query: 508 ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE-------- 559
ERQ R +L + R R E++ E + E+EE+ + E+E
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE---------VPEQEGEPSSIVN 345
Query: 560 -----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQE-----RLERKKRLEEIMKR 609
R + ++E + R EA R +Q ++ RE++E ER+KR+E+ ++
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQ 405
Query: 610 TRRTEATDKKTSDQR 624
RR E ++ + R
Sbjct: 406 RRRLEEQQRREREAR 420
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/165 (31%), Positives = 86/165 (52%), Gaps = 7/165 (4%)
Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ 510
P PSS VN ++ + E+ R Q+ +E++ REQEE +RQ
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENK---ERSEALRRQQLLQEQQLREQEEYKRQ 390
Query: 511 KREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE 570
E +R+ +++ RR E ++ +AR ++E+ QR+ E+ R EE ER R+KEE
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELER--RRKEE 448
Query: 571 EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
E R R E E+ R ERE+ + R + E E ++ LE + ++ + +A
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLE--EEQRHLEVLQQQLLQEQA 491
Score = 68.9 bits (167), Expect = 2e-11
Identities = 47/139 (33%), Positives = 74/139 (53%), Gaps = 22/139 (15%)
Query: 477 EEATRLLAEKRRLAREQREK----EERERREQEELERQKREELAQRVAEERTTRREEESR 532
E +LLAE+++ +Q+E+ EE++RRE+E +Q+RE+ R +EE R
Sbjct: 386 EYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQ---------RRREQEEKR 436
Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEAR---------VREEAERVRQ 583
RLE + R KEE+ +R+AEE R E E +RQ EEE R ++E+A +
Sbjct: 437 RLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHD 496
Query: 584 EREKHFQREEQERLERKKR 602
R H Q +Q +++R
Sbjct: 497 HRRPHPQHSQQPPPPQQER 515
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/155 (32%), Positives = 82/155 (52%), Gaps = 21/155 (13%)
Query: 488 RLAREQREKEERE------RREQEELERQKREELA-QRVAEERTTRREEESRRLEAEQAR 540
R +++ EK+E E E+EE+ Q+ E + V E T RR+ RL+ E +
Sbjct: 308 RTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD--FLRLQQEN-K 364
Query: 541 EKEEQLQRQA--EERALREREE------AERAQR---QKEEEARVREEAERVRQEREKHF 589
E+ E L+RQ +E+ LRE+EE AER +R QKE+ R+ E+ R R+ R +
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+ + + E K+RLEE+ +R + E + ++R
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/91 (38%), Positives = 54/91 (59%), Gaps = 6/91 (6%)
Query: 66 RQRLA-RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
RQ LA R++R E++K+ R RE AR+ E+ E+R++ EE+R+ EE R
Sbjct: 389 RQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQER--EQRRREQEEKRRLEELERRRK 446
Query: 125 EEKRRQRLEEDK---ERHEAVVRRTMERSQK 152
EE+ R+R EE+K ER + +RR +E Q+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Score = 53.1 bits (126), Expect = 9e-07
Identities = 62/213 (29%), Positives = 101/213 (47%), Gaps = 34/213 (15%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKH----LEERKKRLEEQRQ-KEE 118
+ R+RL ++R ERE A R+ ERE+R R+ EK LE R+K EE+R+ +EE
Sbjct: 404 EQRRRLEEQQRRERE---ARRQ---QEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ--------KPKQKHNRWSWGGSLHGS- 169
+RR E++ +R E+++RH V+++ + + Q +P +H++ S
Sbjct: 458 KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSK 517
Query: 170 PSIHSADP-------DR-RSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPW 221
PS H+ +P DR R V S+ PV+S+R S + + +R
Sbjct: 518 PSFHAPEPKAHYEPADRAREVPVRTTSR--SPVLSRRDSPLQGSGQQNSQAGQRNS---- 571
Query: 222 ESSVVNRLLTPTHSFLARSKSTAALSGEAASCS 254
SS+ RLL L + + SG + S S
Sbjct: 572 TSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGS 604
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/113 (28%), Positives = 60/113 (53%), Gaps = 9/113 (7%)
Query: 56 DPPPVLRVDDRQRLARE----RREEREKQLAAREIVWLEREE-RARQHYEKHL-EERKKR 109
+P ++ V L R+ ++E +E+ A R L+ ++ R ++ Y++ L ER+KR
Sbjct: 339 EPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398
Query: 110 LE---EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+E EQR++ E ++ E RRQ+ E + R + RR E ++ K++ R
Sbjct: 399 IEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 8/100 (8%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQ-------HYEKHLEERKKRLEEQRQKEER 119
Q+ +ER E +Q +E E+EE RQ E+ E+R++ E+QR++ E
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
RR E+RR R +E+K R E + RR E ++ + + +
Sbjct: 420 RRQQEREQRR-REQEEKRRLEELERRRKEEEERRRAEEEK 458
Score = 35.0 bits (79), Expect = 0.25
Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 27/135 (20%)
Query: 508 ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE-------- 559
ERQ R +L + R R E++ E + E+EE+ + E+E
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE---------VPEQEGEPSSIVN 345
Query: 560 -----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQE-----RLERKKRLEEIMKR 609
R + ++E + R EA R +Q ++ RE++E ER+KR+E+ ++
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQ 405
Query: 610 TRRTEATDKKTSDQR 624
RR E ++ + R
Sbjct: 406 RRRLEEQQRREREAR 420
Score = 32.7 bits (73), Expect = 1.3
Identities = 45/202 (22%), Positives = 77/202 (38%), Gaps = 21/202 (10%)
Query: 477 EEATRLLAEKRRLAREQREK----EERER--REQEELERQKREE------LAQRVAEERT 524
+E R L E R +E+ E+ EE+ R REQE + RQ EE L Q++ +E+
Sbjct: 432 QEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQA 491
Query: 525 TRREEESR-RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ 583
+ R + Q +Q + + A + E A R +E R + V
Sbjct: 492 MLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSP-VLS 550
Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALP 643
R+ Q Q+ + +R R +K + + G+ G++ + P
Sbjct: 551 RRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPGSHP 610
Query: 644 CTTNAPG-------NGKPVGSP 658
+ + G + K GSP
Sbjct: 611 GSQSGSGERFRVRSSSKSEGSP 632
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 78.6 bits (192), Expect = 2e-14
Identities = 52/165 (31%), Positives = 86/165 (52%), Gaps = 7/165 (4%)
Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ 510
P PSS VN ++ + E+ R Q+ +E++ REQEE +RQ
Sbjct: 334 PEQEGEPSSIVNVPGESTLRRDFLRLQQENK---ERSEALRRQQLLQEQQLREQEEYKRQ 390
Query: 511 KREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEE 570
E +R+ +++ RR E ++ +AR ++E+ QR+ E+ R EE ER R+KEE
Sbjct: 391 LLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELER--RRKEE 448
Query: 571 EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEA 615
E R R E E+ R ERE+ + R + E E ++ LE + ++ + +A
Sbjct: 449 EERRRAEEEKRRVEREQEYIRRQLE--EEQRHLEVLQQQLLQEQA 491
Score = 72.0 bits (175), Expect = 2e-12
Identities = 42/132 (31%), Positives = 73/132 (55%), Gaps = 2/132 (1%)
Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRR--EEESRRLEAEQAREKE 543
KR+L E++++ E+++ ++ LE Q+R E R +ER RR +EE RRLE + R KE
Sbjct: 388 KRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKE 447
Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
E+ +R+AEE R E E +RQ EEE R E ++ + + +E ++
Sbjct: 448 EEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQA 507
Query: 604 EEIMKRTRRTEA 615
E + ++ ++ +A
Sbjct: 508 ERLQRQLQQEQA 519
Score = 62.0 bits (149), Expect = 2e-09
Identities = 50/155 (32%), Positives = 82/155 (52%), Gaps = 21/155 (13%)
Query: 488 RLAREQREKEERE------RREQEELERQKREELA-QRVAEERTTRREEESRRLEAEQAR 540
R +++ EK+E E E+EE+ Q+ E + V E T RR+ RL+ E +
Sbjct: 308 RTRKKRGEKDETEYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRD--FLRLQQEN-K 364
Query: 541 EKEEQLQRQA--EERALREREE------AERAQR---QKEEEARVREEAERVRQEREKHF 589
E+ E L+RQ +E+ LRE+EE AER +R QKE+ R+ E+ R R+ R +
Sbjct: 365 ERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQE 424
Query: 590 QREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+ + + E K+RLEE+ +R + E + ++R
Sbjct: 425 REQRRREQEEKRRLEELERRRKEEEERRRAEEEKR 459
Score = 54.7 bits (130), Expect = 3e-07
Identities = 35/91 (38%), Positives = 54/91 (59%), Gaps = 6/91 (6%)
Query: 66 RQRLA-RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
RQ LA R++R E++K+ R RE AR+ E+ E+R++ EE+R+ EE R
Sbjct: 389 RQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQER--EQRRREQEEKRRLEELERRRK 446
Query: 125 EEKRRQRLEEDK---ERHEAVVRRTMERSQK 152
EE+ R+R EE+K ER + +RR +E Q+
Sbjct: 447 EEEERRRAEEEKRRVEREQEYIRRQLEEEQR 477
Score = 49.3 bits (116), Expect = 1e-05
Identities = 34/93 (36%), Positives = 57/93 (61%), Gaps = 11/93 (11%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKH----LEERKKRLEEQRQ-KEE 118
+ R+RL ++R ERE A R+ ERE+R R+ EK LE R+K EE+R+ +EE
Sbjct: 404 EQRRRLEEQQRRERE---ARRQ---QEREQRRREQEEKRRLEELERRRKEEEERRRAEEE 457
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQ 151
+RR E++ +R E+++RH V+++ + + Q
Sbjct: 458 KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQ 490
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/113 (28%), Positives = 60/113 (53%), Gaps = 9/113 (7%)
Query: 56 DPPPVLRVDDRQRLARE----RREEREKQLAAREIVWLEREE-RARQHYEKHL-EERKKR 109
+P ++ V L R+ ++E +E+ A R L+ ++ R ++ Y++ L ER+KR
Sbjct: 339 EPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKR 398
Query: 110 LE---EQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+E EQR++ E ++ E RRQ+ E + R + RR E ++ K++ R
Sbjct: 399 IEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEER 451
Score = 45.4 bits (106), Expect = 2e-04
Identities = 31/100 (31%), Positives = 52/100 (52%), Gaps = 8/100 (8%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQ-------HYEKHLEERKKRLEEQRQKEER 119
Q+ +ER E +Q +E E+EE RQ E+ E+R++ E+QR++ E
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
RR E+RR R +E+K R E + RR E ++ + + +
Sbjct: 420 RRQQEREQRR-REQEEKRRLEELERRRKEEEERRRAEEEK 458
Score = 44.7 bits (104), Expect = 3e-04
Identities = 46/209 (22%), Positives = 81/209 (38%), Gaps = 14/209 (6%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK---------E 117
+ L R R+EE E++ A E R ER +++ + LEE ++ LE +Q+ E
Sbjct: 439 EELERRRKEEEERRRAEEE---KRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLE 495
Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGS-PSIHSAD 176
R R E ++ +RL+ ++ +A + ++P +H++ S PS H+ +
Sbjct: 496 CRWREMEEHRQAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFHAPE 555
Query: 177 PDRRSVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWESSVVNRLLTPTHSF 236
P + + ++ V+ K SS R + S N H
Sbjct: 556 P-KAHYEPADRAREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPA 614
Query: 237 LARSKSTAALSGEAASCSPIIMPYKAAHS 265
L R AS + P +HS
Sbjct: 615 LQRPAEPQVQWSHLASLKNNVSPVSRSHS 643
Score = 35.0 bits (79), Expect = 0.25
Identities = 33/135 (24%), Positives = 59/135 (43%), Gaps = 27/135 (20%)
Query: 508 ERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRERE-------- 559
ERQ R +L + R R E++ E + E+EE+ + E+E
Sbjct: 295 ERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEE---------VPEQEGEPSSIVN 345
Query: 560 -----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQE-----RLERKKRLEEIMKR 609
R + ++E + R EA R +Q ++ RE++E ER+KR+E+ ++
Sbjct: 346 VPGESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQ 405
Query: 610 TRRTEATDKKTSDQR 624
RR E ++ + R
Sbjct: 406 RRRLEEQQRREREAR 420
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 77.8 bits (190), Expect = 3e-14
Identities = 42/122 (34%), Positives = 81/122 (66%), Gaps = 7/122 (5%)
Query: 492 EQREKEERERREQEELERQKREELAQRVAE----ERTTRREEESRRLEAEQAREKEEQLQ 547
EQ +K+E + EQEE R++ E++ ++ + E +++EE R + EQ RE+EEQ+
Sbjct: 213 EQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM- 271
Query: 548 RQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ--ERLERKKRLEE 605
R+ EE+ L+++E+ E+ ++ E+E ++RE+ E++R++ E+ ++EEQ E+ E+ + EE
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEE 331
Query: 606 IM 607
M
Sbjct: 332 QM 333
Score = 73.6 bits (179), Expect = 6e-13
Identities = 47/152 (30%), Positives = 93/152 (61%), Gaps = 11/152 (7%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA---QRVAEERTTRREEES 531
+ EE + E+ + EQ K+E + REQEE R++ E++ ++ +E T +EE
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQ 297
Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
R + EQ RE+EEQ++ Q E+ +RE+EE Q K+EE ++ E+ E++ +++E+ +++
Sbjct: 298 MREQEEQMREQEEQMREQEEQ--MREQEE----QMGKQEE-QMWEQKEQMWEQKEQMWKQ 350
Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
EEQ E+++++++ ++ R+ E +K +Q
Sbjct: 351 EEQMG-EQEEQMQKQEEQVRKQEEQMRKQEEQ 381
Score = 72.8 bits (177), Expect = 1e-12
Identities = 41/154 (26%), Positives = 88/154 (57%), Gaps = 6/154 (3%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEEL---ERQKREELAQRVAEERTTRREEESRR 533
EE + E+ R EQ ++E + REQEE ++++ E+ Q +E R +EE R
Sbjct: 247 EEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMR 306
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
+ EQ RE+EEQ++ Q E+ +E + E+ ++ E++ ++ ++ E++ ++ E+ ++EE
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEE 366
Query: 594 QERLER---KKRLEEIMKRTRRTEATDKKTSDQR 624
Q R + +K+ E++ K+ + +++ +Q+
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQK 400
Score = 72.0 bits (175), Expect = 2e-12
Identities = 53/168 (31%), Positives = 94/168 (55%), Gaps = 22/168 (13%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
+ EE + E+ EQ K+E + EQEE + QK+EE Q+ +E R++EE R
Sbjct: 210 EQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEE-QVQKQEEQVQK--QEEQMRKQEEQMRE 266
Query: 535 EAEQAREKEEQLQRQAE-----------ERALREREEAERAQRQ--KEEEARVREEAERV 581
+ EQ RE+EEQ+ +Q E E +RE+EE R Q + +E+E ++RE+ E++
Sbjct: 267 QEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQM 326
Query: 582 RQEREKHFQREEQ--ERLERKKRLEEIM----KRTRRTEATDKKTSDQ 623
++ E+ ++++EQ E+ E+ + EE M ++ ++ E +K +Q
Sbjct: 327 GKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQ 374
Score = 70.1 bits (170), Expect = 7e-12
Identities = 41/145 (28%), Positives = 87/145 (60%), Gaps = 10/145 (6%)
Query: 477 EEATRLLAEKRRLAREQREKEERER-REQEELERQKREELAQRVAEERTTRREEESRRLE 535
E+ ++L +K + +E++ E+ E+ REQEE R++ E++ + +E R +EE +
Sbjct: 273 EQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMRE---QEEQMREQEEQMGKQ 329
Query: 536 AEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQE 595
EQ E++EQ+ Q E+ +E + E+ ++ +++E +VR++ E++R++ E+ ++EEQ
Sbjct: 330 EEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389
Query: 596 RL------ERKKRLEEIMKRTRRTE 614
R E+K+++ E ++ R E
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQE 414
Score = 69.7 bits (169), Expect = 9e-12
Identities = 39/145 (26%), Positives = 91/145 (62%), Gaps = 5/145 (3%)
Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAE--ERTTRREEES 531
T+ EE T E+ R EQ ++E + REQEE R++ E++ ++ + E+ + E+
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344
Query: 532 RRL--EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHF 589
++ + EQ E+EEQ+Q+Q E+ +E + ++ ++ +++E ++R++ E++ +++E+
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404
Query: 590 QREEQERLERKKRLEEIMKRTRRTE 614
+++EQ R E+++++ E ++ R+ E
Sbjct: 405 EQKEQMR-EQEEQMGEQKEQMRKQE 428
Score = 66.6 bits (161), Expect = 8e-11
Identities = 45/148 (30%), Positives = 82/148 (55%), Gaps = 5/148 (3%)
Query: 477 EEATRLLAEKRRLAREQ--REKEERERREQE-ELERQKREELAQRVAEERTTRREEESRR 533
EE R E+ R EQ ++KE+ E+ EQ E E Q RE+ Q +E R +EE R
Sbjct: 261 EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
+ EQ ++EEQ+ Q E+ ++ + ++ ++ E+E +++++ E+VR++ E+ ++EE
Sbjct: 321 EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE 380
Query: 594 QERL--ERKKRLEEIMKRTRRTEATDKK 619
Q R E+ ++ EE M + K+
Sbjct: 381 QMRKQEEQMRKQEEQMGEQKEQMGEQKE 408
Score = 65.9 bits (159), Expect = 1e-10
Identities = 43/162 (26%), Positives = 88/162 (54%), Gaps = 7/162 (4%)
Query: 467 VKTSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTR 526
V+ G +E E + +E + E+ E+ ++E + QK+EE Q +E R
Sbjct: 173 VREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE--QMGEQEEQMR 230
Query: 527 REEESRRLEAEQAREKEEQLQRQAEERALRE---REEAERAQRQKEEEARVREEAERVRQ 583
++EE + EQ +++EEQ+Q+Q E+ +E RE+ E+ + Q+E+ + +E+ E+ Q
Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQ 290
Query: 584 --EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
E+E+ + +E++ E+++++ E ++ R E K +Q
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQ 332
Score = 65.1 bits (157), Expect = 2e-10
Identities = 37/130 (28%), Positives = 71/130 (54%), Gaps = 11/130 (8%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEEL-----------ERQKREELAQRVAEER 523
+ EE R E+ R EQ K+E + EQ+E E Q E+ Q +E
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEE 366
Query: 524 TTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ 583
R++EE R + EQ R++EEQ+++Q E+ ++ + E+ ++ +E+E ++ E+ E++R+
Sbjct: 367 QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426
Query: 584 EREKHFQREE 593
+ E +++E
Sbjct: 427 QEEHMGEQKE 436
Score = 63.5 bits (153), Expect = 7e-10
Identities = 38/141 (26%), Positives = 77/141 (54%), Gaps = 2/141 (1%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
E+ REQ + + + E E Q RE+ Q +E +E + EQ E+EE
Sbjct: 154 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEE 213
Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ--ERLERKKR 602
Q+Q+Q E+ +E + ++ ++ E+E +V+++ E+V+++ E+ ++EEQ E+ E+ +
Sbjct: 214 QMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMRE 273
Query: 603 LEEIMKRTRRTEATDKKTSDQ 623
EE M + + +++T +Q
Sbjct: 274 QEEQMLKQKEQTEQEEQTGEQ 294
Score = 60.1 bits (144), Expect = 7e-09
Identities = 39/141 (27%), Positives = 78/141 (55%), Gaps = 3/141 (2%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
E+ REQ + + + E E Q RE+ Q +E +EE + EQ +++EE
Sbjct: 161 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEE 220
Query: 545 QLQRQAEERALREREEAERAQR-QKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
Q+ Q E+ +E + E+ ++ QK+EE V+++ E++R++ E+ ++EEQ R + ++ L
Sbjct: 221 QMGEQEEQMRKQEEQMGEQEEQVQKQEEQ-VQKQEEQMRKQEEQMREQEEQMREQEEQML 279
Query: 604 EEIMKRTRRTEATDKKTSDQR 624
++ ++T + E T ++ R
Sbjct: 280 KQ-KEQTEQEEQTGEQEEQMR 299
Score = 59.7 bits (143), Expect = 1e-08
Identities = 38/140 (27%), Positives = 76/140 (54%), Gaps = 4/140 (2%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
E+ REQ + + + E E Q E+ Q +E +EE + + EQ E+EE
Sbjct: 168 EQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEE 227
Query: 545 QLQRQAEERALRERE-EAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRL 603
Q+++Q E+ +E + + + Q QK+EE +R++ E++R++ E+ RE++E++ ++K
Sbjct: 228 QMRKQEEQMGEQEEQVQKQEEQVQKQEEQ-MRKQEEQMREQEEQ--MREQEEQMLKQKEQ 284
Query: 604 EEIMKRTRRTEATDKKTSDQ 623
E ++T E ++ +Q
Sbjct: 285 TEQEEQTGEQEEQMREQEEQ 304
Score = 57.4 bits (137), Expect = 5e-08
Identities = 34/139 (24%), Positives = 73/139 (52%), Gaps = 4/139 (2%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
E+ REQ + + + E E Q RE+ Q +E R +E R + Q RE+E
Sbjct: 133 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 192
Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLE 604
Q+ Q + +E + E+ ++ +++E ++ E+ E++R++ E+ ++EEQ +K+ E
Sbjct: 193 QMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQV----QKQEE 248
Query: 605 EIMKRTRRTEATDKKTSDQ 623
++ K+ + +++ +Q
Sbjct: 249 QVQKQEEQMRKQEEQMREQ 267
Score = 55.8 bits (133), Expect = 1e-07
Identities = 35/140 (25%), Positives = 71/140 (50%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
E+ REQ + + + E E Q RE+ Q +E R +E R + Q RE+E
Sbjct: 119 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 178
Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLE 604
Q++ Q + +E + E+ + E+E ++ E+ E+++++ E+ ++EEQ R + ++ E
Sbjct: 179 QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGE 238
Query: 605 EIMKRTRRTEATDKKTSDQR 624
+ + ++ E K+ R
Sbjct: 239 QEEQVQKQEEQVQKQEEQMR 258
Score = 53.9 bits (128), Expect = 5e-07
Identities = 48/191 (25%), Positives = 89/191 (46%), Gaps = 16/191 (8%)
Query: 447 PVPTPAMVSAPSSTVNAS-ASVKTSAGTTDPEEATRLLAEKRRLAREQR---EKEERERR 502
P+P V V V+ G +E + E+ REQ ++E + R
Sbjct: 47 PLPQEGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEGQVR 104
Query: 503 EQE----ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALRER 558
EQE E E Q RE+ Q +E R +E R + Q RE+E Q++ Q + +E
Sbjct: 105 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 164
Query: 559 EEAERAQRQKEEEARVREEAERVRQ------EREKHFQREEQERLERKKRLEEIMKRTRR 612
+ E+ + +E+E +VRE+ +VR+ E+E +E++ E+++++++ ++
Sbjct: 165 QVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE 224
Query: 613 TEATDKKTSDQ 623
E +K +Q
Sbjct: 225 QEEQMRKQEEQ 235
Score = 50.8 bits (120), Expect = 4e-06
Identities = 47/179 (26%), Positives = 85/179 (47%), Gaps = 7/179 (3%)
Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAE-KRRLAREQRE-KEERERREQE--- 505
P + + NA + T+ E + E KR+L ++ +E + REQE
Sbjct: 2 PRITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQV 61
Query: 506 -ELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERA 564
E E Q RE+ Q +E R +E R + Q RE+E Q++ Q + +E + E+
Sbjct: 62 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 121
Query: 565 QRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
+ +E+E +VRE+ +VR E+E + +E + E++ ++ E + R E ++ Q
Sbjct: 122 GQVREQEGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 179
Score = 43.9 bits (102), Expect = 5e-04
Identities = 25/83 (30%), Positives = 51/83 (61%), Gaps = 2/83 (2%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRRAAVEEKRR 129
E+ E+E+Q+ +E E+EE+ R+ E+ EE+ ++ EEQ QK+E + EE+ R
Sbjct: 206 EQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMR 265
Query: 130 QRLEEDKERHEAVVRRTMERSQK 152
++ E+ +E+ E ++++ + Q+
Sbjct: 266 EQEEQMREQEEQMLKQKEQTEQE 288
Score = 42.0 bits (97), Expect = 0.002
Identities = 26/101 (25%), Positives = 54/101 (53%), Gaps = 9/101 (8%)
Query: 60 VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
V + +++ R E+ E+E+Q+ +E L+++E+ Q EE+ EEQ +++E
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQ------EEQTGEQEEQMREQEE 303
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
+ EE+ R++ E+ +E+ E + + + Q +QK W
Sbjct: 304 QMREQEEQMREQEEQMREQEEQMGK---QEEQMWEQKEQMW 341
Score = 41.6 bits (96), Expect = 0.003
Identities = 21/97 (21%), Positives = 53/97 (54%), Gaps = 2/97 (2%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+++ + E+ +++E+Q+ +E E+EE+ R+ E+ L+++++ +E++ E+ +
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMR 299
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
+E++ + EE E +R + Q KQ+ W
Sbjct: 300 EQEEQMREQEEQMREQEEQMRE--QEEQMGKQEEQMW 334
Score = 40.8 bits (94), Expect = 0.005
Identities = 21/94 (22%), Positives = 54/94 (57%), Gaps = 1/94 (1%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK-EERRRA 122
+++ R E+ E+E+Q+ +E E+EE+ + E+ E++++ E++ Q ++ +
Sbjct: 295 EEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM 354
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E++ Q+ EE + E +R+ E+ +K +++
Sbjct: 355 GEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQ 388
Score = 38.1 bits (87), Expect = 0.030
Identities = 21/92 (22%), Positives = 49/92 (53%), Gaps = 3/92 (3%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYE---KHLEERKKRLEEQRQKEERR 120
+++ + E+ E+E+Q+ +E E+EE+ ++ E K E+ +K+ E+ R++EE+
Sbjct: 212 EEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQM 271
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
R E+ +Q+ + ++E M ++
Sbjct: 272 REQEEQMLKQKEQTEQEEQTGEQEEQMREQEE 303
Score = 38.1 bits (87), Expect = 0.030
Identities = 19/96 (19%), Positives = 54/96 (56%), Gaps = 1/96 (1%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+++ R E+ E+E+Q+ +E ++EE+ R+ E+ + E+++++ EQ ++ +++
Sbjct: 226 EEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQ-EEQMREQEEQMREQEEQMLKQKEQ 284
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E++ + +E++ R + R E + +++ R
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320
Score = 37.4 bits (85), Expect = 0.051
Identities = 23/96 (23%), Positives = 55/96 (57%), Gaps = 5/96 (5%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERK---KRLEEQRQKEERR 120
+++ R E+ E+E+Q+ +E ++EE+ + E+ E+++ K+ E+ ++EE+
Sbjct: 302 EEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ E+ R+Q EE + E +R+ E+ +K +++
Sbjct: 362 QKQEEQVRKQ--EEQMRKQEEQMRKQEEQMRKQEEQ 395
Score = 36.6 bits (83), Expect = 0.088
Identities = 22/93 (23%), Positives = 49/93 (52%), Gaps = 8/93 (8%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ- 130
E+ E+E+Q+ +E E+EE+ R+ E+ E+ ++ +++ Q E++ E+K +
Sbjct: 289 EQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348
Query: 131 -------RLEEDKERHEAVVRRTMERSQKPKQK 156
EE ++ E VR+ E+ +K +++
Sbjct: 349 KQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQ 381
Score = 36.6 bits (83), Expect = 0.088
Identities = 20/89 (22%), Positives = 43/89 (48%), Gaps = 5/89 (5%)
Query: 75 EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEE 134
E++E+ +E +W + E+ Q E+ +K+ E+ R++EE+ R E+ R+Q +
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQE-----EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQM 389
Query: 135 DKERHEAVVRRTMERSQKPKQKHNRWSWG 163
K+ + ++ QK + + G
Sbjct: 390 RKQEEQMGEQKEQMGEQKEQMREQEEQMG 418
Score = 36.6 bits (83), Expect = 0.088
Identities = 22/90 (24%), Positives = 52/90 (57%), Gaps = 5/90 (5%)
Query: 71 RERREEREKQLAAREIVWLEREERARQHYE--KHLEERKKRLEEQRQKEERRRAAVEEKR 128
+E+ ++E+Q+ +E ++EE+ R+ E + EE+ ++ EEQ +K+E + +E+
Sbjct: 344 KEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQM 403
Query: 129 RQRLEEDKERHEAVVRRTMERSQKPKQKHN 158
++ E+ +E+ E + ++ Q KQ+ +
Sbjct: 404 GEQKEQMREQEEQMGE---QKEQMRKQEEH 430
Score = 34.3 bits (77), Expect = 0.43
Identities = 16/72 (22%), Positives = 42/72 (58%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+++ + E+ ++E+Q+ +E ++EE+ R+ E+ E++++ E++ Q E+
Sbjct: 358 EEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQM 417
Query: 124 VEEKRRQRLEED 135
E+K + R +E+
Sbjct: 418 GEQKEQMRKQEE 429
Score = 33.9 bits (76), Expect = 0.57
Identities = 28/115 (24%), Positives = 58/115 (50%), Gaps = 4/115 (3%)
Query: 45 GQNNNHSGNKPDPPPVLRVDDRQRLARERR-EEREKQLAAREIVWLEREERARQHYE--K 101
GQ G + +R + Q +E + E+E Q+ +E E+EE+ + E +
Sbjct: 157 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQ 216
Query: 102 HLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
EE+ EEQ +K+E + +E++ Q+ EE ++ E +R+ E+ ++ +++
Sbjct: 217 KQEEQMGEQEEQMRKQEEQMGE-QEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQ 270
>gi|7662238 apoptotic chromatin condensation inducer 1 [Homo sapiens]
Length = 1341
Score = 77.4 bits (189), Expect = 4e-14
Identities = 61/214 (28%), Positives = 93/214 (43%), Gaps = 45/214 (21%)
Query: 437 PAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAREQREK 496
P P P P PV P A E+ + A + + A +RE
Sbjct: 1114 PRPLHPPPPPPVQPPQHPRA--------------------EQREQERAVREQWAEREREM 1153
Query: 497 EERER-REQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERAL 555
E RER R + E +R K E + + R RR+E ++ E+ EK+E+ Q + + L
Sbjct: 1154 ERRERTRSEREWDRDKVREGPRSRSRSRDRRRKERAK--SKEKKSEKKEKAQEEPPAKLL 1211
Query: 556 RE----------------------REEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
+ ++EAERA+R KE E R +E+ E ++EREK +RE
Sbjct: 1212 DDLFRKTKAAPCIYWLPLTDSQIVQKEAERAERAKEREKRRKEQEEEEQKEREKEAERER 1271
Query: 594 QERLERKKRLEEIMKRTRRTEATDKKTSDQRNGD 627
+LER+KR E +R R E ++ R+ D
Sbjct: 1272 NRQLEREKRREHSRERDRERERERERDRGDRDRD 1305
Score = 52.4 bits (124), Expect = 2e-06
Identities = 33/116 (28%), Positives = 58/116 (50%), Gaps = 11/116 (9%)
Query: 486 KRRLAREQREKEERERREQEELERQK-REELAQRVAEERTTRREEESRRLEAEQAREKEE 544
++ R +R KE +RR+++E E QK RE+ A+R E +R+LE E+ RE
Sbjct: 1236 QKEAERAERAKEREKRRKEQEEEEQKEREKEAER----------ERNRQLEREKRREHSR 1285
Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERK 600
+ R+ E R+R + +R + + E R R+ + R R + ++R R+
Sbjct: 1286 ERDRERERERERDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGRR 1341
Score = 51.2 bits (121), Expect = 3e-06
Identities = 68/287 (23%), Positives = 118/287 (41%), Gaps = 18/287 (6%)
Query: 458 SSTVNASASVKTSAGTTDPEEATRLLAEKRRL---AREQREKEERERREQEELERQKREE 514
SS V + + K S G+ EE R L A + EE E E+EE E + EE
Sbjct: 228 SSRVRQARAAKLSEGSQPAEEEEDQETPSRNLRVRADRNLKTEEEEEEEEEEEEDDEEEE 287
Query: 515 LAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQR--QKEEEA 572
+ R +E + E R K E++ + + +E+E ER R + +EEA
Sbjct: 288 GDDEGQKSREAPILKEFKEEGEEIPRVKPEEMMDERPKTRSQEQEVLERGGRFTRSQEEA 347
Query: 573 RVREEAERVRQEREKHFQREEQ-ERLERKKRLEEIMKRTRRTEATDKKTSDQRNGD-IAK 630
R ++ RQ++EK + E ER+ + + +K ++ + + T D++ +A
Sbjct: 348 R---KSHLARQQQEKEMKTTSPLEEEEREIKSSQGLKEKSKSPSPPRLTEDRKKASLVAL 404
Query: 631 GALTGGTEVSALPCTTNAPGNGKPVGSPHVVTSHQSKVTVESTPDLEKQ---PNENGVSV 687
T E + P T + P P + + + + P + Q PN + +
Sbjct: 405 PEQTASEEETPPPLLTKEASSPPP--HPQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTR 462
Query: 688 QNENFEEIINLPIGSKP-SRLDVTNSESP--EIPLNPILAFDDEGTL 731
+ + + L G P S T +ESP ++P +L + TL
Sbjct: 463 ELLVSQHTVQLVGGLSPLSSPSDTKAESPAEKVPEESVLPLVQKSTL 509
Score = 51.2 bits (121), Expect = 3e-06
Identities = 25/104 (24%), Positives = 48/104 (46%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
+EA R K R R + ++EE ++ ++E ER++ +L + E + R+ E R
Sbjct: 1237 KEAERAERAKEREKRRKEQEEEEQKEREKEAERERNRQLEREKRREHSRERDRERERERE 1296
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
+++ +R E R+R + +R R + VR+ R
Sbjct: 1297 RDRGDRDRDRERDRERGRERDRRDTKRHSRSRSRSTPVRDRGGR 1340
Score = 43.5 bits (101), Expect = 7e-04
Identities = 29/98 (29%), Positives = 51/98 (52%), Gaps = 15/98 (15%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R +R++ +E+ EE +K ERE+ A + + LE R+KR E R+++ R
Sbjct: 1244 RAKEREKRRKEQEEEEQK----------EREKEAERERNRQLE-REKRREHSRERDRERE 1292
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E+ R R + D++R E R ER ++ ++H+R
Sbjct: 1293 ---RERERDRGDRDRDR-ERDRERGRERDRRDTKRHSR 1326
Score = 43.5 bits (101), Expect = 7e-04
Identities = 29/94 (30%), Positives = 45/94 (47%), Gaps = 5/94 (5%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
R+ E ++EREK+ LERE+R R+H + ER++ E R +R R
Sbjct: 1252 RKEQEEEEQKEREKEAERERNRQLEREKR-REHSRERDRERERERERDRGDRDRDRERDR 1310
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E+ R+R D +RH R+ RS + + R
Sbjct: 1311 ERGRERDRRDTKRHS----RSRSRSTPVRDRGGR 1340
Score = 43.1 bits (100), Expect = 0.001
Identities = 35/132 (26%), Positives = 60/132 (45%), Gaps = 27/132 (20%)
Query: 55 PDPPPVL-----RVDDR--QRLARERREEREKQLAAREIVWLERE-------ERARQHYE 100
P PPPV R + R +R RE+ ERE+++ RE ERE E R
Sbjct: 1120 PPPPPVQPPQHPRAEQREQERAVREQWAEREREMERRERTRSEREWDRDKVREGPRSRSR 1179
Query: 101 KHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEA-------------VVRRTM 147
RK+R + + +K E++ A EE + L++ + +A +V++
Sbjct: 1180 SRDRRRKERAKSKEKKSEKKEKAQEEPPAKLLDDLFRKTKAAPCIYWLPLTDSQIVQKEA 1239
Query: 148 ERSQKPKQKHNR 159
ER+++ K++ R
Sbjct: 1240 ERAERAKEREKR 1251
Score = 39.7 bits (91), Expect = 0.010
Identities = 63/326 (19%), Positives = 115/326 (35%), Gaps = 49/326 (15%)
Query: 373 KREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPA 432
+RE+K K+ K P K +A LV + E T E P + A + P
Sbjct: 371 EREIKSSQGLKEKSKSPSPPRLTEDRK-KASLVALPEQTASEEETPPPLLTKEASSPPPH 429
Query: 433 PASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTD----------------- 475
P P P P + +P +T + + S T
Sbjct: 430 PQLHSEEEIEPMEGPAPPVLIQLSPPNTDADTRELLVSQHTVQLVGGLSPLSSPSDTKAE 489
Query: 476 ------PEEATRLLAEKRRLAREQREKE---ERERREQEELERQKREELAQRVAEE---R 523
PEE+ L +K LA +K+ E +R Q + + LA+ + EE +
Sbjct: 490 SPAEKVPEESVLPLVQKSTLADYSAQKDLEPESDRSAQPLPLKIEELALAKGITEECLKQ 549
Query: 524 TTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK---------EEEARV 574
+ ++E RR A +L++ A+ + R + + R + + +
Sbjct: 550 PSLEQKEGRR--ASHTLLPSHRLKQSADSSSSRSSSSSSSSSRSRSRSPDSSGSRSHSPL 607
Query: 575 REEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALT 634
R + V Q R H + ++ + E + R+ + + + +++ + T
Sbjct: 608 RSKQRDVAQAR-THANPRGRPKMGSRSTSESRSRSRSRSRSASSNSRKSLSPGVSRDSST 666
Query: 635 GGTEVSALPCTTNAPGNGKPVGSPHV 660
TE T P +G+ V +P V
Sbjct: 667 SYTE-------TKDPSSGQEVATPPV 685
Score = 39.3 bits (90), Expect = 0.014
Identities = 44/200 (22%), Positives = 77/200 (38%), Gaps = 20/200 (10%)
Query: 451 PAMVSAPSSTVNASASVKTSAGTTDPEEATRLL-----AEKRRLARE-QREKEERERREQ 504
P V ST A ++ P +A R+ E+R LA+ Q+ + +
Sbjct: 46 PEAVGTDPSTSRKMAELEEVTLDGKPLQALRVTDLKAALEQRGLAKSGQKSALVKRLKGA 105
Query: 505 EELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALREREEAERA 564
LE ++ + + EE S+ +Q EK+++L RQ ER RE E E A
Sbjct: 106 LMLENLQKHSTPHAAFQPNSQIGEEMSQNSFIKQYLEKQQELLRQRLEREAREAAELEEA 165
Query: 565 QRQKEEE------------ARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRR 612
+ E+E + ER E +H R+ E K ++ ++ R+
Sbjct: 166 SAESEDEMIHPEGVASLLPPDFQSSLERPELELSRHSPRKSSSISEEKGDSDD--EKPRK 223
Query: 613 TEATDKKTSDQRNGDIAKGA 632
E + R +++G+
Sbjct: 224 GERRSSRVRQARAAKLSEGS 243
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 77.4 bits (189), Expect = 4e-14
Identities = 52/165 (31%), Positives = 95/165 (57%), Gaps = 18/165 (10%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL---AQRVAEERTTRREEESRR 533
EE R +K R E+ ++E REQE R++ E++ +R+ E+ RE+E
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKEL 337
Query: 534 LEAEQAREKEEQLQRQAE-----ERALREREEAERAQRQK--EEEARVREEAERVRQERE 586
E ++ RE+EEQ+Q Q E E +RE+EE Q ++ E+E ++RE+ +++R + E
Sbjct: 338 REQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEE 397
Query: 587 KHFQ-----REEQERL-ERKKRLEEI--MKRTRRTEATDKKTSDQ 623
+ ++ RE++ER+ E++K E++ M+ ++ + +KKT DQ
Sbjct: 398 RMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ 442
Score = 75.1 bits (183), Expect = 2e-13
Identities = 45/152 (29%), Positives = 91/152 (59%), Gaps = 12/152 (7%)
Query: 483 LAEKRRLAREQREK----EERERREQEELERQKREELAQRVAEERTTRREEESRRL--EA 536
L E+ REQ EK E+R R +++EL Q++E Q+ E+ + +E+ ++ +
Sbjct: 302 LREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQE 361
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ-- 594
E+ RE+EE++ RQ E +E++ E+ Q+ +++E R+ E+ ER+R++ E+ ++E+
Sbjct: 362 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 421
Query: 595 --ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E++ +K+++E K+TR E +K ++R
Sbjct: 422 QVEKMREEKKMQEQEKKTRDQE--EKMQEEER 451
Score = 72.0 bits (175), Expect = 2e-12
Identities = 46/164 (28%), Positives = 99/164 (60%), Gaps = 19/164 (11%)
Query: 477 EEATRLLAEKRRLAREQRE--KEERERREQEEL---ERQKREELAQRVAEERTTRREEES 531
E+ ++ +++RL +++E ++E+E REQ+EL E Q +E+ + +E R +EE
Sbjct: 311 EQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEK 370
Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEA--ERAQRQKEEEARVR------EEAERVRQ 583
+ E+ E+E+Q++ Q E+ +R++EE E+ +R +E+E R+R E+ E++R+
Sbjct: 371 MWRQEERLWEQEKQMREQ--EQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMRE 428
Query: 584 EREKHFQ----REEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
E++ Q R+++E+++ ++R+ E K+ R E T ++ ++
Sbjct: 429 EKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK 472
Score = 70.5 bits (171), Expect = 5e-12
Identities = 50/153 (32%), Positives = 85/153 (55%), Gaps = 11/153 (7%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKRE-ELAQRVAEERTTRREEESRRLE 535
+E + E+ REQ EK R+ E E+Q RE E R EER ++E R E
Sbjct: 351 QEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKE 410
Query: 536 AEQAREKE---EQLQRQAEERALREREEAERAQRQK-EEEARVREEAERVRQEREKHFQR 591
E+ RE+E EQ+++ EE+ ++E+E+ R Q +K +EE R+RE +++R+E E R
Sbjct: 411 -ERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEET--MR 467
Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E++E+++++ EE M E ++ +Q+
Sbjct: 468 EQEEKMQKQ---EENMWEQEEKEWQQQRLPEQK 497
Score = 70.5 bits (171), Expect = 5e-12
Identities = 45/159 (28%), Positives = 93/159 (58%), Gaps = 22/159 (13%)
Query: 485 EKRRLAREQREKEERERREQEELERQKRE-ELAQRVAEERTTRREEESRRLEAEQAREKE 543
E++ +EQ+ ++ ER E++ E++K+ + +++ EE R E+ R E E RE+E
Sbjct: 550 EEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQE 609
Query: 544 EQLQRQAEERALREREEA--ERAQRQKEEEARVREEAERVRQEREK-------------- 587
E++Q Q E+ ++E+EE E+ ++ +E+E ++ E+ E++ ++ EK
Sbjct: 610 EKMQEQEEK--MQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKL 667
Query: 588 --HFQREEQERL-ERKKRLEEIMKRTRRTEATDKKTSDQ 623
H + +EQE++ E+++++ E K ++T+ +KKT DQ
Sbjct: 668 WEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ 706
Score = 68.9 bits (167), Expect = 2e-11
Identities = 52/152 (34%), Positives = 90/152 (59%), Gaps = 17/152 (11%)
Query: 476 PEEATRLLAEKR-RLAREQREKEERERREQEEL----ERQKREELAQRVAEERTTRREEE 530
P+ T L E+ R E RE+E++ R+++E++ ER + +E R EE+ R+E+
Sbjct: 263 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKR 322
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERV-RQ---- 583
R E E RE+E++L+ Q E LRE+EE + Q +K E+E ++RE+ E++ RQ
Sbjct: 323 LREQEKE-LREQEKELREQKE---LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERL 378
Query: 584 -EREKHFQREEQERLERKKRLEEIMKRTRRTE 614
E+EK + +EQ+ ++++R+ E +R R E
Sbjct: 379 WEQEKQMREQEQKMRDQEERMWEQDERLREKE 410
Score = 68.9 bits (167), Expect = 2e-11
Identities = 42/164 (25%), Positives = 95/164 (57%), Gaps = 10/164 (6%)
Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEELERQKREELA-----QRVAEERTTRREEE 530
PE+ +L ++ +E+ +++E + EQE++E++ +E+ +++ EE + R E+
Sbjct: 661 PEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREK 720
Query: 531 SRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREK--- 587
R E E RE+EE++Q Q E+ +E E E+ ++ E+E ++ E+ +R+ +++EK
Sbjct: 721 KMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQ-QRLPEQKEKLWE 779
Query: 588 HFQREEQERL-ERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAK 630
H + +EQE++ E+++++ + ++ R E + ++ G K
Sbjct: 780 HEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK 823
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/158 (25%), Positives = 91/158 (57%), Gaps = 11/158 (6%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRRE---EESRR 533
E+ ++ ++ RL ++++ E+E++ +++ ER ++ R EER +E E+ +
Sbjct: 366 EQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEK 425
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
+ E+ +++E+ R EE+ E ER ++ +EEE +RE+ E+++++ E +++EE
Sbjct: 426 MREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE 485
Query: 594 ----QERL-ERKKRL---EEIMKRTRRTEATDKKTSDQ 623
Q+RL E+K++L E++ ++ + ++K DQ
Sbjct: 486 KEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 523
Score = 66.6 bits (161), Expect = 8e-11
Identities = 44/164 (26%), Positives = 94/164 (57%), Gaps = 26/164 (15%)
Query: 485 EKRRLAREQREKEERERREQEEL--ERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
EK R +Q ++E + R+QE+ ++++R E + E++T +EE+ R E + REK
Sbjct: 537 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREK 596
Query: 543 ----EEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREEQ-- 594
EE++ R+ EE+ ++E+EE + Q +K E+E +++E+ E++ ++ EK +++EE+
Sbjct: 597 KMREEEEMMREQEEK-MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMW 655
Query: 595 ---------------ERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
E+++ +++++E ++ E +KKT +Q
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQ 699
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/174 (22%), Positives = 93/174 (53%), Gaps = 27/174 (15%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQ--RVAEERTTRREEESRRL 534
E+ R+ +++ + ++ +EE++ +EQE+ R + E++ + R+ E REEE
Sbjct: 408 EKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMR 467
Query: 535 EAEQAREKEEQLQRQAEERALRERE---------EAERAQRQK----EEEARVREE---- 577
E E+ +K+E+ + EE+ +++ E E+ Q Q+ E+E ++R++
Sbjct: 468 EQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Query: 578 --------AERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
E++R++ ++ +++EE+ R + +K ++ + ++T+ +KKT DQ
Sbjct: 528 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQ 581
Score = 63.2 bits (152), Expect = 9e-10
Identities = 44/166 (26%), Positives = 88/166 (53%), Gaps = 17/166 (10%)
Query: 476 PEEATRLLAEKRRLAREQREKEERER-REQEEL--------ERQKREELAQRVAEERTTR 526
PE+ +L +++ +E++ E+ E+ R+QEE+ ++K E ++ E+
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM 553
Query: 527 REEESRRLEAEQAREKEEQLQRQA----EERALREREEAERAQRQKEEEARVREEAERVR 582
R++E + + E+ EK+ Q Q + EE+ E ER ++ +EEE +RE+ E+++
Sbjct: 554 RDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 613
Query: 583 QEREKHFQREEQ--ERLERKKRLEEIM--KRTRRTEATDKKTSDQR 624
++ EK ++EE+ E+ E+ + EE M + + E +K QR
Sbjct: 614 EQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQR 659
Score = 62.4 bits (150), Expect = 1e-09
Identities = 46/167 (27%), Positives = 89/167 (53%), Gaps = 16/167 (9%)
Query: 473 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQ--KREELAQRVAEERTTRREEE 530
T D EE R R ++ RE+EE R ++E+++ Q K +E +++ E+ +E+E
Sbjct: 578 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQE 637
Query: 531 SRRLEAEQAR-EKEEQLQRQA----EERALREREEAERAQRQKEEEARV--REEAERVRQ 583
+ E E+ E+EE++ Q ++ L E E+ + ++ +E+E ++ +E+ E+ Q
Sbjct: 638 EKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQ 697
Query: 584 EREKHF-----QREEQERLERKKRL--EEIMKRTRRTEATDKKTSDQ 623
E+EK REE+ ER+K++ EE M R + + +++ Q
Sbjct: 698 EQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQ 744
Score = 62.0 bits (149), Expect = 2e-09
Identities = 41/131 (31%), Positives = 80/131 (61%), Gaps = 10/131 (7%)
Query: 497 EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALR 556
+E R++EEL Q+++ Q EE+ R+EE R E + RE+EE++ RQ E+ LR
Sbjct: 271 QEEMWRQEEELREQEKKIRKQ---EEKMWRQEERLREQEGKM-REQEEKMWRQ--EKRLR 324
Query: 557 EREEAERAQ-RQKEEEARVREEAERVRQEREKHFQREEQERLERKK---RLEEIMKRTRR 612
E+E+ R Q ++ E+ +RE+ E+++++ EK +++EE+ R + +K + E + ++ ++
Sbjct: 325 EQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384
Query: 613 TEATDKKTSDQ 623
++K DQ
Sbjct: 385 MREQEQKMRDQ 395
Score = 60.8 bits (146), Expect = 4e-09
Identities = 41/150 (27%), Positives = 83/150 (55%), Gaps = 7/150 (4%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
+ EE + EK E+ ++E + EQ+ L QK + +E+ +E+E +
Sbjct: 628 EQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIW 687
Query: 535 EAEQAREK-EEQLQRQAEERALREREEA-ERAQRQKEEEARVREEAERVRQEREKHFQRE 592
E E+ +K +EQ ++ ++ +RE E ER ++ +EEE +RE+ E++ QE+E+ Q +
Sbjct: 688 EQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKM-QEQEEKMQEQ 746
Query: 593 EQERLERKKRL----EEIMKRTRRTEATDK 618
E+E E+++++ E++ ++ R E +K
Sbjct: 747 EEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776
Score = 59.3 bits (142), Expect = 1e-08
Identities = 42/147 (28%), Positives = 75/147 (51%), Gaps = 13/147 (8%)
Query: 481 RLLAEKRRLAREQREKEERERR-EQEELERQKREELAQRVAEERTTR-REEESRRLEAEQ 538
RL +K +L +++ +E+ E+ EQEE R + E Q R + RE+E + E E+
Sbjct: 492 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEE 551
Query: 539 AREKEEQLQRQAEERALREREEAER-----------AQRQKEEEARVREEAERVRQEREK 587
+EQ EER ++ +E E+ +R +E E ++REE E +R++ EK
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 588 HFQREEQERLERKKRLEEIMKRTRRTE 614
++EE+ + + +K E+ K + E
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEE 638
Score = 58.9 bits (141), Expect = 2e-08
Identities = 36/130 (27%), Positives = 71/130 (54%), Gaps = 4/130 (3%)
Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQ--KREELAQRVAEERTTRREEES 531
T +E EK R RE+E++ R E+E + Q K +E +++ E+ E+E
Sbjct: 696 TQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEE 755
Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
+ E E+ ++++L Q E+ L E E+ + ++ E+E ++R++ E++R + EK +
Sbjct: 756 KMWEQEEKMWEQQRLPEQKEK--LWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQ 813
Query: 592 EEQERLERKK 601
EE+ R + +K
Sbjct: 814 EEKMRGQEEK 823
Score = 58.2 bits (139), Expect = 3e-08
Identities = 38/157 (24%), Positives = 92/157 (58%), Gaps = 20/157 (12%)
Query: 477 EEATRLLAEKRRLAREQ---REKEERERREQEEL-ERQKREELAQRVAEERTTRREEESR 532
+E R+ ++++ E+ RE+EE+ ++++E + E++++E QR+ E++ E+E
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 506
Query: 533 RLEAEQAREKEEQLQRQAE----------ERALREREEA--ERAQRQKEEEARVREEAER 580
+ + E+ E+EE+++ Q E + +RE+E+ E+ ++ +++E ++ ++ ER
Sbjct: 507 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 566
Query: 581 V---RQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
+ QE+EK +++E++ ++R+ E K+ R E
Sbjct: 567 MEKKTQEQEKK-TWDQEEKMREEERMREREKKMREEE 602
Score = 58.2 bits (139), Expect = 3e-08
Identities = 49/152 (32%), Positives = 88/152 (57%), Gaps = 21/152 (13%)
Query: 485 EKRRLAREQREK--EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
E++RL EQ+EK E + +EQE+++ Q+ + Q E++T +E+E + + E+ RE+
Sbjct: 656 EQQRLP-EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKT--QEQEKKTWDQEKMREE 712
Query: 543 EEQLQRQAEERALREREEAERAQRQK----EEEARVREEAERVRQEREKHFQRE----EQ 594
E +R E+ +RE EE R Q +K EE+ +E+ E + ++ EK +++E EQ
Sbjct: 713 ESMRER---EKKMREEEEMMREQEEKMQEQEEKM--QEQEEEMWEQEEKMWEQEEKMWEQ 767
Query: 595 ERL-ERKKRL--EEIMKRTRRTEATDKKTSDQ 623
+RL E+K++L E M+ + ++K DQ
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQ 799
Score = 57.8 bits (138), Expect = 4e-08
Identities = 42/155 (27%), Positives = 81/155 (52%), Gaps = 16/155 (10%)
Query: 478 EATRLLAEKRRLAREQREK---EERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
E + + E+ REQ EK +E EQEE E Q+ QR+ E++ E+E +
Sbjct: 454 EREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQ-----QRLPEQKEKLWEQEKMQE 508
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREE- 593
+ E+ E+EE+++ Q E + ++ R ++ +E+E ++ E+ E++R + +K + +EE
Sbjct: 509 QEEKIWEQEEKIRDQ--EEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 566
Query: 594 -----QERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
QE+ ++ EE M+ R +KK ++
Sbjct: 567 MEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 601
Score = 57.0 bits (136), Expect = 6e-08
Identities = 41/147 (27%), Positives = 79/147 (53%), Gaps = 9/147 (6%)
Query: 478 EATRLLAEKRRLAREQREKEE-----RERREQEELERQKREELAQRVAEERTTRREEESR 532
E L EK REQ + E RE ++ +E E++ R++ +++ EE R E+
Sbjct: 401 EQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQ-EEKMQEEERIREREKKM 459
Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
R E E RE+EE++Q+Q E + E+EE E Q++ E+ E E++ QE+E+ +
Sbjct: 460 REEEETMREQEEKMQKQEEN--MWEQEEKEWQQQRLPEQKEKLWEQEKM-QEQEEKIWEQ 516
Query: 593 EQERLERKKRLEEIMKRTRRTEATDKK 619
E++ ++++ + K R+ + +++
Sbjct: 517 EEKIRDQEEMWGQEKKMWRQEKMREQE 543
Score = 56.2 bits (134), Expect = 1e-07
Identities = 48/172 (27%), Positives = 89/172 (51%), Gaps = 24/172 (13%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE---ES 531
+ EE R EK + E+ +++E + EQEE +++ E++ ++ EE+ +EE E
Sbjct: 600 EEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQ--EEKMWEQEEKMWEQ 657
Query: 532 RRL--------------EAEQAREKEEQLQRQAE-ERALREREEAERAQRQKEEEARVRE 576
+RL E E+ +E+EE++ Q + E+ +E+E+ Q + EE +RE
Sbjct: 658 QRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMRE 717
Query: 577 EAERVRQEREKHFQREE--QERLERKKRLEEIM--KRTRRTEATDKKTSDQR 624
+++R+E E ++EE QE+ E+ + EE M + + E +K QR
Sbjct: 718 REKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQR 769
Score = 54.3 bits (129), Expect = 4e-07
Identities = 38/152 (25%), Positives = 81/152 (53%), Gaps = 8/152 (5%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
EE + EK+ E+ +E+ E+ +++E + Q++EE + E+ E+E + E
Sbjct: 711 EEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE---EMWEQEEKMWEQEEKMWEQ 767
Query: 537 EQAREKEEQL---QRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQR 591
++ E++E+L ++ E+ + E+EE R Q +K +E ++R + E++R + EK + +
Sbjct: 768 QRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQ 827
Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
EE+ + +K + K + E ++K Q
Sbjct: 828 EEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQ 859
Score = 54.3 bits (129), Expect = 4e-07
Identities = 35/128 (27%), Positives = 71/128 (55%), Gaps = 7/128 (5%)
Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAE 537
E RL +K +L ++ +E+ + EQEE R + E++ +E R +EE R + E
Sbjct: 766 EQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMR---GQEEKMRGQEEKMRGQEE 822
Query: 538 QAREKEEQLQRQAEERALRER----EEAERAQRQKEEEARVREEAERVRQEREKHFQREE 593
+ +EE++ Q E+ +E +E + ++ + +E ++RE+ E++R + EK ++EE
Sbjct: 823 KMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEE 882
Query: 594 QERLERKK 601
+ R + +K
Sbjct: 883 KMRGQEEK 890
Score = 53.1 bits (126), Expect = 9e-07
Identities = 45/156 (28%), Positives = 78/156 (50%), Gaps = 23/156 (14%)
Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEER---------- 523
T +A L + + E+ +K+ E +E+ L ++ E+ V E +
Sbjct: 203 TKERDALSLELYRNTITNEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLL 262
Query: 524 ----TTRREEESRRLEAEQAREKEEQLQRQAE-----ERALREREEAERAQRQK--EEEA 572
T +EE R E E+ RE+E+++++Q E E LRE+E R Q +K +E
Sbjct: 263 PQVQTNTLQEEMWRQE-EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEK 321
Query: 573 RVREEAERVR-QEREKHFQREEQERLERKKRLEEIM 607
R+RE+ + +R QE+E Q+E +E+ E+ + EE M
Sbjct: 322 RLREQEKELREQEKELREQKELREQEEQMQEQEEKM 357
Score = 53.1 bits (126), Expect = 9e-07
Identities = 47/165 (28%), Positives = 89/165 (53%), Gaps = 27/165 (16%)
Query: 475 DPEEATRLLAEKRRLAREQR-EKEERERREQ------EEL-ERQKREELAQRVAEERTTR 526
+ EE R EK + E E+EE+E ++Q E+L E++K +E +++ E+
Sbjct: 461 EEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKI 520
Query: 527 RE------EESRRLEAEQAREKEEQLQRQAE-----ERALREREEAERAQRQKEE----- 570
R+ +E + E+ RE+E+Q+ Q E E+ + ++EE + Q++E
Sbjct: 521 RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWD 580
Query: 571 -EARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
E ++REE ER+R EREK + EE+ E++++++E ++ + E
Sbjct: 581 QEEKMREE-ERMR-EREKKMREEEEMMREQEEKMQEQEEKMQEQE 623
Score = 53.1 bits (126), Expect = 9e-07
Identities = 36/152 (23%), Positives = 78/152 (51%), Gaps = 8/152 (5%)
Query: 478 EATRLLAEKRRLAREQREK----EERERREQEELERQKREELAQRVAEERTTRREEESRR 533
E + + E+ + REQ EK EE+ + ++EE+ Q+ + Q R E+ +
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQR 591
L + +++E++ Q E+ +R++EE R Q +K +E ++R + E++ + EK + +
Sbjct: 777 LWEHEKMQEQEKIWEQEEK--MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQ 834
Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
EE+ + +K + K + + ++K +Q
Sbjct: 835 EEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQ 866
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/159 (25%), Positives = 85/159 (53%), Gaps = 12/159 (7%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREEL--AQRVAE------ERTTR 526
+ EE R EK + E+ +++E E EQEE ++ E++ QR+ E E
Sbjct: 724 EEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 783
Query: 527 REEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQE 584
+E+E + E+ R++EE+++ Q E+ +R +EE R Q +K +E ++ + E++ +
Sbjct: 784 QEQEKIWEQEEKMRDQEEKMRGQEEK--MRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQ 841
Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
EK + +EE+ + + + E++ ++ + ++K +Q
Sbjct: 842 EEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQ 880
Score = 48.9 bits (115), Expect = 2e-05
Identities = 44/147 (29%), Positives = 80/147 (54%), Gaps = 15/147 (10%)
Query: 483 LAEKRRLAREQREKEERERRE-QEELERQK--REELAQRVAEERTTRREEESRRLEAEQA 539
L EK LA ++ + + +E + +LER K ++ +E R+EEE R E ++
Sbjct: 230 LQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE-KKI 288
Query: 540 REKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREE-QER 596
R++EE++ RQ E LRE+E R Q +K +E R+RE QE+E Q +E +E+
Sbjct: 289 RKQEEKMWRQEER--LREQEGKMREQEEKMWRQEKRLRE------QEKELREQEKELREQ 340
Query: 597 LERKKRLEEIMKRTRRTEATDKKTSDQ 623
E +++ E++ ++ + ++K +Q
Sbjct: 341 KELREQEEQMQEQEEKMWEQEEKMREQ 367
Score = 45.4 bits (106), Expect = 2e-04
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 8/102 (7%)
Query: 64 DDRQRLARERREEREK-----QLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
D+R R ER E+EK + E E+E++ R EK EE + R E++ +EE
Sbjct: 403 DERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREE 462
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
+E++ Q+ EE+ E + ++ + P+QK W
Sbjct: 463 EETMREQEEKMQKQEENMWEQE---EKEWQQQRLPEQKEKLW 501
Score = 45.4 bits (106), Expect = 2e-04
Identities = 36/127 (28%), Positives = 65/127 (51%), Gaps = 22/127 (17%)
Query: 476 PEEATRLLAEKRRLAREQREKEERERREQEEL-----ERQKREELAQRVAEERTTRREEE 530
PE+ +L ++ +E+ ++E + R+QEE E+ + +E R EE+ +EE+
Sbjct: 771 PEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEK 830
Query: 531 SRRLEAE----------QAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
E + Q + EE++Q Q E+ +RE+EE R Q +K +RE+ E+
Sbjct: 831 MWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEK--MREQEEKMRGQEEK-----MREQEEK 883
Query: 581 VRQEREK 587
+R + EK
Sbjct: 884 MRGQEEK 890
Score = 44.7 bits (104), Expect = 3e-04
Identities = 27/89 (30%), Positives = 49/89 (55%), Gaps = 9/89 (10%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQR 131
ER EREK++ E + E+EE+ ++ EK E+ +K E++ + +E+ EEK ++
Sbjct: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQ-----EEKMWEQ 643
Query: 132 LEEDKERHEAVVRRTMERSQKPKQKHNRW 160
E+ E+ E + E+ + P+QK W
Sbjct: 644 EEKMWEQEE----KMWEQQRLPEQKEKLW 668
Score = 43.1 bits (100), Expect = 0.001
Identities = 24/99 (24%), Positives = 57/99 (57%), Gaps = 3/99 (3%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+++ + E+ +E+E+++ +E E+EE+ + EK E+ +K E+QR E++ +
Sbjct: 609 EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLW 668
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
EK +++ E+ +E+ E + + E+ +K Q+ + +W
Sbjct: 669 EHEKMQEQ-EKMQEQEEKIWEQ--EKMEKKTQEQEKKTW 704
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/109 (28%), Positives = 60/109 (55%), Gaps = 14/109 (12%)
Query: 65 DRQRLARERRE--EREKQLAAREIVWLEREERARQHYEK------HLEERKKRLEEQRQK 116
++++ RE++E E+E+Q+ +E E+EE+ R+ EK L E++K++ EQ QK
Sbjct: 332 EQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQK 391
Query: 117 ---EERRRAAVEEKRR---QRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+E R +E+ R +R+ E ++ E V + E+ + ++K R
Sbjct: 392 MRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
Score = 42.7 bits (99), Expect = 0.001
Identities = 22/80 (27%), Positives = 45/80 (56%), Gaps = 1/80 (1%)
Query: 64 DDRQRLARERR-EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
D +++ E R EREK++ E E+EE+ ++ E E+ +K ++QR E++ +
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKL 500
Query: 123 AVEEKRRQRLEEDKERHEAV 142
+EK +++ E+ E+ E +
Sbjct: 501 WEQEKMQEQEEKIWEQEEKI 520
Score = 42.4 bits (98), Expect = 0.002
Identities = 32/108 (29%), Positives = 51/108 (47%), Gaps = 21/108 (19%)
Query: 72 ERREEREKQLAAR--------EIVWLEREERARQHYEKHLEERK-----------KRLEE 112
ER E+EKQ+ + E +W E++ER R+ E+ E+ K K+++E
Sbjct: 376 ERLWEQEKQMREQEQKMRDQEERMW-EQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434
Query: 113 QRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
Q +K + ++E+ R R E K R E R E + KQ+ N W
Sbjct: 435 QEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQ-KQEENMW 481
Score = 42.0 bits (97), Expect = 0.002
Identities = 25/89 (28%), Positives = 51/89 (57%), Gaps = 3/89 (3%)
Query: 66 RQRLARERRE--EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+QRL ++ + E+EK E +W E+EE+ R E +E+K +E+ +++E +
Sbjct: 490 QQRLPEQKEKLWEQEKMQEQEEKIW-EQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWE 548
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQK 152
EEK R + ++ ++ E + ++T E+ +K
Sbjct: 549 QEEKMRDQEQKMWDQEERMEKKTQEQEKK 577
Score = 40.8 bits (94), Expect = 0.005
Identities = 29/162 (17%), Positives = 67/162 (41%), Gaps = 6/162 (3%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERRRAAV 124
+RL + +E RE++ RE L +E Q E+ + +E K R +E++ + R
Sbjct: 321 KRLREQEKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 380
Query: 125 EEK----RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRR 180
+EK + Q++ + +ER R E+ ++ +++ W + + + R
Sbjct: 381 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTR 440
Query: 181 SVSTMNLSKYVDPVISKRLSSSSATLLNSPDRARRLQLSPWE 222
+ K++ T+ ++ ++ + + WE
Sbjct: 441 DQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 482
Score = 40.8 bits (94), Expect = 0.005
Identities = 22/86 (25%), Positives = 43/86 (50%), Gaps = 1/86 (1%)
Query: 72 ERREEREKQLAAREIVW-LEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
E+ +E+EK E +W E+ E+ Q EK +++K EE+ +E ++ EE+ +
Sbjct: 671 EKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMR 730
Query: 131 RLEEDKERHEAVVRRTMERSQKPKQK 156
EE + E ++ E + ++K
Sbjct: 731 EQEEKMQEQEEKMQEQEEEMWEQEEK 756
Score = 40.4 bits (93), Expect = 0.006
Identities = 24/97 (24%), Positives = 54/97 (55%), Gaps = 5/97 (5%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
D + +E++ R++++ +E E+EE+ R +K + ++++R+E++ Q++E++
Sbjct: 522 DQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQK-MWDQEERMEKKTQEQEKKTWD 580
Query: 124 VEEKRRQ----RLEEDKERHEAVVRRTMERSQKPKQK 156
EEK R+ R E K R E + R E + +++
Sbjct: 581 QEEKMREEERMREREKKMREEEEMMREQEEKMQEQEE 617
Score = 40.4 bits (93), Expect = 0.006
Identities = 21/95 (22%), Positives = 48/95 (50%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
++ D+++ ++ E EK+ +E ++EE+ R+ E+K R EE+ +E+ +
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E++ Q EE E ++ E+ + ++K
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEK 646
Score = 40.0 bits (92), Expect = 0.008
Identities = 26/98 (26%), Positives = 54/98 (55%), Gaps = 3/98 (3%)
Query: 60 VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQ--KE 117
+ + +++ ER E+E ++ +E +E+R R+ EK L E++K L EQ++ ++
Sbjct: 288 IRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQ-EKELREQEKELREQKELREQ 346
Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
E + EEK ++ E+ +E+ E + R+ ++ KQ
Sbjct: 347 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 384
Score = 39.7 bits (91), Expect = 0.010
Identities = 36/157 (22%), Positives = 80/157 (50%), Gaps = 12/157 (7%)
Query: 470 SAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
SA +T ++A R + E + + R EEL++ K EL +++ + + E
Sbjct: 186 SAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKK-KNAELQEKLPLAESEKSEI 244
Query: 530 ESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHF 589
+ E ++ E+ + L Q + L+E RQ+EE +RE+ +++R++ EK +
Sbjct: 245 QLNVKELKRKLERAKFLLPQVQTNTLQEE-----MWRQEEE---LREQEKKIRKQEEKMW 296
Query: 590 QREEQERLER---KKRLEEIMKRTRRTEATDKKTSDQ 623
++EE+ R + +++ E++ ++ +R +K+ +Q
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQ 333
Score = 38.9 bits (89), Expect = 0.018
Identities = 28/99 (28%), Positives = 52/99 (52%), Gaps = 9/99 (9%)
Query: 62 RVDDRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
R+ +R++ RE E E+E+++ +E E+EE+ + EK E+ +K E++ + E
Sbjct: 590 RMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWE 649
Query: 119 RRRAAVEEKRRQRLEEDKER---HEAVVRRTMERSQKPK 154
+ E+ QRL E KE+ HE + + + Q+ K
Sbjct: 650 QEEKMWEQ---QRLPEQKEKLWEHEKMQEQEKMQEQEEK 685
Score = 38.9 bits (89), Expect = 0.018
Identities = 29/98 (29%), Positives = 48/98 (48%), Gaps = 10/98 (10%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
D + E EREK++ E + E+EE+ ++ EK E+ EE+ ++E +
Sbjct: 705 DQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQ-----EEEMWEQEEKMWE 759
Query: 124 VEEK--RRQRLEEDKER---HEAVVRRTMERSQKPKQK 156
EEK +QRL E KE+ HE + + Q+ K +
Sbjct: 760 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMR 797
Score = 38.5 bits (88), Expect = 0.023
Identities = 26/102 (25%), Positives = 52/102 (50%), Gaps = 7/102 (6%)
Query: 65 DRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
+R++ RE E E+E+++ +E E+EE + EK E+ +K E+QR E++ +
Sbjct: 717 EREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEK 776
Query: 122 AAVEEKRRQR----LEEDKERHEAVVRRTMERSQKPKQKHNR 159
EK +++ +E+K R + R E + +++ R
Sbjct: 777 LWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMR 818
Score = 38.1 bits (87), Expect = 0.030
Identities = 28/110 (25%), Positives = 50/110 (45%), Gaps = 15/110 (13%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQH-------------YEKHLEERKKRL 110
++ R E RE+ +K E +W +EER R+ EK L E++K L
Sbjct: 272 EEMWRQEEELREQEKKIRKQEEKMW-RQEERLREQEGKMREQEEKMWRQEKRLREQEKEL 330
Query: 111 EEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
EQ +KE R + + E+ Q E++++ E + + + +Q+ W
Sbjct: 331 REQ-EKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 379
Score = 37.7 bits (86), Expect = 0.039
Identities = 24/94 (25%), Positives = 47/94 (50%), Gaps = 4/94 (4%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
Q ++ +E+EK+ +E + E R R+ + EE + EE+ Q++E + EE
Sbjct: 689 QEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEE 748
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
+ ++ E+ E+ E + E+ + P+QK W
Sbjct: 749 EMWEQEEKMWEQEE----KMWEQQRLPEQKEKLW 778
Score = 37.7 bits (86), Expect = 0.039
Identities = 25/105 (23%), Positives = 53/105 (50%), Gaps = 9/105 (8%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEK-----HLEERKKRLEEQRQKEE 118
++ R E+ +E+E+++ +E E+EE+ + EK L E+K++L E + +E
Sbjct: 726 EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQE 785
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWG 163
+ + +E++ + EE E +R E+ + ++K WG
Sbjct: 786 QEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK----MWG 826
Score = 37.4 bits (85), Expect = 0.051
Identities = 27/102 (26%), Positives = 55/102 (53%), Gaps = 4/102 (3%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR-LEEQRQKEERR 120
R ++R R + E+E+++ +E E+E+ R+ ++ E+++ R EEQ Q++E +
Sbjct: 297 RQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
Query: 121 RAAVEEKRRQRLEE---DKERHEAVVRRTMERSQKPKQKHNR 159
EEK R++ E+ +ER ++ E+ QK + + R
Sbjct: 357 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 398
Score = 37.4 bits (85), Expect = 0.051
Identities = 25/104 (24%), Positives = 52/104 (50%), Gaps = 10/104 (9%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERK--KRLEEQRQKEERRRAAV 124
+++ E++ + +++ + ++ EER R+ +K EE + + EE+ QK+E
Sbjct: 424 EKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQ 483
Query: 125 EEK--RRQRLEEDK------ERHEAVVRRTMERSQKPKQKHNRW 160
EEK ++QRL E K E+ + + E+ +K + + W
Sbjct: 484 EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 527
Score = 37.4 bits (85), Expect = 0.051
Identities = 23/96 (23%), Positives = 46/96 (47%), Gaps = 9/96 (9%)
Query: 61 LRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
+R +++ +E R E++ Q E+E++ EK EE + R E++ +EE
Sbjct: 553 MRDQEQKMWDQEERMEKKTQ---------EQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E++ Q EE + E + E+ Q+ ++K
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEK 639
Score = 35.8 bits (81), Expect = 0.15
Identities = 23/114 (20%), Positives = 59/114 (51%), Gaps = 10/114 (8%)
Query: 55 PDPPPVLRVDDRQRLARERREEREKQLAAREIVW-----LEREERARQHYEKHLEERKKR 109
P+ L ++ + E+ E+E+++ +E +W + R+E+ R+ E + E++++
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ-EDQMWEQEEK 552
Query: 110 LEEQRQK----EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ +Q QK EER +E+ ++ +++++ E R E+ + +++ R
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR 606
Score = 34.7 bits (78), Expect = 0.33
Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 20/105 (19%)
Query: 72 ERREEREKQL-------AAREIVWLEREERARQ------------HYEKHLEERKKRLEE 112
+R+ ER K L +E +W + EE Q E+ L E++ ++ E
Sbjct: 252 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 311
Query: 113 QRQKEERRRAAVEEKRRQRLEEDKE-RHEAVVRRTMERSQKPKQK 156
Q +K R+ + E+ ++ E++KE R + +R E+ Q+ ++K
Sbjct: 312 QEEKMWRQEKRLREQEKELREQEKELREQKELREQEEQMQEQEEK 356
Score = 34.7 bits (78), Expect = 0.33
Identities = 20/87 (22%), Positives = 46/87 (52%), Gaps = 8/87 (9%)
Query: 75 EEREKQLAAREIVW-----LEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRR 129
E+ EK E +W E++E+ +H + +E+ + EE+ ++E+ +E+ +
Sbjct: 642 EQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEK 701
Query: 130 QRLEEDKERHEAVVRRTMERSQKPKQK 156
+ +++K R E +R ER +K +++
Sbjct: 702 KTWDQEKMREEESMR---EREKKMREE 725
Score = 34.3 bits (77), Expect = 0.43
Identities = 21/91 (23%), Positives = 47/91 (51%), Gaps = 6/91 (6%)
Query: 72 ERREEREKQLAAREIVW----LEREERARQHYEKHLEERK--KRLEEQRQKEERRRAAVE 125
E+ E+++ +E +W ++ +E+ ++ EK E+ K K+ +EQ +K + E
Sbjct: 652 EKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMRE 711
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
E+ + E+ E ++R E+ Q+ ++K
Sbjct: 712 EESMREREKKMREEEEMMREQEEKMQEQEEK 742
Score = 31.2 bits (69), Expect = 3.7
Identities = 28/113 (24%), Positives = 54/113 (47%), Gaps = 23/113 (20%)
Query: 65 DRQRLARERRE--EREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERR 120
++QRL ++ + E EK + +E +W E+EE+ R EK EE+ + EE+ + +E +
Sbjct: 766 EQQRLPEQKEKLWEHEK-MQEQEKIW-EQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEK 823
Query: 121 RAAVEEK-----------------RRQRLEEDKERHEAVVRRTMERSQKPKQK 156
EEK + +++EE + E +R E+ + ++K
Sbjct: 824 MWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEK 876
Score = 31.2 bits (69), Expect = 3.7
Identities = 20/79 (25%), Positives = 44/79 (55%), Gaps = 1/79 (1%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+++ R E+ +E+++ +E +EE+ EK E+ + + E+ R++EE+ R
Sbjct: 814 EEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQ 873
Query: 124 VEEKRRQRLEEDKERHEAV 142
EEK R++ E+ + + E +
Sbjct: 874 -EEKMREQEEKMRGQEEKI 891
Score = 30.4 bits (67), Expect = 6.3
Identities = 22/92 (23%), Positives = 45/92 (48%), Gaps = 4/92 (4%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERRRAAVEEKRR 129
E+ ++E+++ +E +EE+ R EK EE+ EE+ +E + EEK
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKME 853
Query: 130 QRL--EEDKERHEAVVRRTMERSQKPKQKHNR 159
+++ +E+K R + R E + +++ R
Sbjct: 854 EKMQGQEEKMREQEEKMRGQEEKMREQEEKMR 885
Score = 30.0 bits (66), Expect = 8.2
Identities = 20/85 (23%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+++ R E+ +E+++ +E +EE+ EK + +K E+ + +EE+ R
Sbjct: 807 EEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMR-- 864
Query: 124 VEEKRRQRLEEDKERHEAVVRRTME 148
E++ + R +E+K R + R E
Sbjct: 865 -EQEEKMRGQEEKMREQEEKMRGQE 888
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 77.0 bits (188), Expect = 6e-14
Identities = 46/138 (33%), Positives = 88/138 (63%), Gaps = 6/138 (4%)
Query: 489 LAREQREKEER-ERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQ 547
L ++Q EK R E + QE+ E+ +EL R EE+ R+EE+ E E+ RE+E+++
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQE-EKIREQEDKMW 349
Query: 548 RQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREEQERLERKKRLEE 605
RQ E+ +RE+EE R Q +K +E ++RE+ E+++++ E+ +++EE+ R + +KR E+
Sbjct: 350 RQEEK--IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEK 407
Query: 606 IMKRTRRTEATDKKTSDQ 623
+ ++ ++ D+K +Q
Sbjct: 408 MWRQEKKMREQDEKIREQ 425
Score = 70.1 bits (170), Expect = 7e-12
Identities = 49/155 (31%), Positives = 92/155 (59%), Gaps = 14/155 (9%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL---AQRVAEERTTR-----RE 528
EE R EK R E+ ++E + REQ+E +++ EE+ +++ E+ R R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQERE 586
E+ R + E+ RE+EE++ RQ E+ +RE EE + Q +K E E +++EE E+++++ E
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEK--IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 587 KHFQREE--QERLERKKRLEEIMKRTRRTEATDKK 619
K ++EE QE+ E+ R E+++K+ + ++K
Sbjct: 470 KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504
Score = 68.2 bits (165), Expect = 3e-11
Identities = 48/142 (33%), Positives = 86/142 (60%), Gaps = 11/142 (7%)
Query: 477 EEATRLLAEKRRLAREQREKEERER----REQEE---LERQKREELAQRVAEERTTRRE- 528
EE R EKR+ ++EK+ RE+ REQEE + +K EL + + ++ RE
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453
Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKH 588
EE + E E+ +E+EE++QRQ EE+ + E+ R ++ ++E ++ E+ E++ ++ EK
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQ-EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Query: 589 FQREE--QERLERKKRLEEIMK 608
+++EE QE+ E+ +R EE M+
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMR 534
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/137 (29%), Positives = 85/137 (62%), Gaps = 12/137 (8%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ ++ ++ ++ R++ + E+E + +E+ ++ R+E R EE+ +EE+ R E
Sbjct: 315 EQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE- 373
Query: 537 EQAREKEEQLQRQAEE-----RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
E+ RE++E++Q Q EE +RE+EE +R ++ +E ++RE+ E++R++ E+ +++
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEE-KRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Query: 592 EEQERLERKKRLEEIMK 608
EE+ R LEE+M+
Sbjct: 433 EEKIR-----ELEEMMQ 444
Score = 67.8 bits (164), Expect = 4e-11
Identities = 43/151 (28%), Positives = 86/151 (56%), Gaps = 5/151 (3%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQK--REELAQRVAEERTTRREEESRRL 534
EE R EK + E+ ++E + REQEE ++K R+E R +E+ +EEE R
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
E E+ RE EE +Q Q E+ E + E ++ +E+E +++ + E+++++ EK +++E+
Sbjct: 433 E-EKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491
Query: 595 ERLERK--KRLEEIMKRTRRTEATDKKTSDQ 623
+ E K ++ E++ ++ + ++K +Q
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQ 522
Score = 63.9 bits (154), Expect = 5e-10
Identities = 38/141 (26%), Positives = 82/141 (58%), Gaps = 4/141 (2%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ ++ ++ ++ R++ + E+E + +E+ E+ R+E R +E+ +EEE R E
Sbjct: 336 EQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE- 394
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE---EAERVRQEREKHFQREE 593
E+ RE+EE+ Q + + + RE+ E+ + Q+EE R E E E + Q++E+ + E
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 594 QERLERKKRLEEIMKRTRRTE 614
++ E +++++E ++ +R E
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQE 475
Score = 60.5 bits (145), Expect = 6e-09
Identities = 35/138 (25%), Positives = 79/138 (57%), Gaps = 4/138 (2%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEEL---ERQKREELAQRVAEERTTRREEES 531
+ EE EK R E + +E + RE EE E +K +E +++ + +E+E
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEE 483
Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
+ E+ ++EE++ Q E+ +E + E+ ++ +E+E +++ + E++R++ + +Q+
Sbjct: 484 KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Query: 592 EEQERLERKKRLEEIMKR 609
EE+ + E++ RL+E+ +R
Sbjct: 544 EEKMQ-EQEVRLQELEER 560
Score = 60.5 bits (145), Expect = 6e-09
Identities = 41/150 (27%), Positives = 85/150 (56%), Gaps = 12/150 (8%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
D EE R + EK +E+EE+ + ++E+++RQ+ + Q EE+T R+E+ +
Sbjct: 445 DQEEKLREVEEK------MQEEEEKMQEQEEKIQRQEEKIQEQ---EEKTWRQEKLLK-- 493
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
+ E+ E+EE++ RQ E+ +E + E+ ++ + +E ++RE+ R+ Q+ EK Q +E
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK-MQEQEV 552
Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E ++RL ++ ++ +++ QR
Sbjct: 553 RLQELEERLGKLGQKAELLGGAGRESGSQR 582
Score = 56.2 bits (134), Expect = 1e-07
Identities = 44/152 (28%), Positives = 84/152 (55%), Gaps = 14/152 (9%)
Query: 481 RLLAEKRRLAREQREKEERERREQEELE-----RQKREELAQRVAEERTTRREEESRRLE 535
+L E RL +E + + + + EE E Q++EE R E+ +E+E + E
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKI---QEQEEKMCE 315
Query: 536 AE-QAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQRE 592
E + RE+EE++ RQ E+ + E+EE R Q K +E ++RE+ E++R++ EK R+
Sbjct: 316 QELKIREQEEKMWRQEEK--MHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK-MWRQ 372
Query: 593 EQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E++ E+ ++++E + R E ++ ++R
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKR 404
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/166 (24%), Positives = 87/166 (52%), Gaps = 22/166 (13%)
Query: 477 EEATRLL-AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
+E RL+ +EK + ++ + + R Q L +Q+ + A R+ +E + + ++E
Sbjct: 224 QEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE 283
Query: 536 AEQA-----REKEEQLQRQAE----------ERALREREEAERAQRQKEEEARVREEAER 580
+ +++EE++ RQ E E+ L+ RE+ E+ RQ+E ++ E+ E+
Sbjct: 284 ENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEE---KMHEQEEK 340
Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE---ATDKKTSDQ 623
+R++ +K +++EE+ R + +K E+ K R+ E D+K +Q
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ 386
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 4/120 (3%)
Query: 60 VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
+ R +++ + E+ +EK L E +W + E+ RQ E+ + E++++++EQ +K +R
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ--EEKMWEQEEKMQEQEEKMQR 528
Query: 120 RRAAVEEK--RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADP 177
+ + E+ R + EE + E ++ ER K QK G GS + + P
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP 588
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/86 (25%), Positives = 48/86 (55%), Gaps = 1/86 (1%)
Query: 72 ERREEREKQLAAREIVWLEREERA-RQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
E+ +E+E+++ +E+ E+EE+ RQ + H +E K R +E + + + +E++ +
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363
Query: 131 RLEEDKERHEAVVRRTMERSQKPKQK 156
EE R E +R E+ Q+ +++
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEE 389
Score = 39.7 bits (91), Expect = 0.010
Identities = 28/102 (27%), Positives = 56/102 (54%), Gaps = 12/102 (11%)
Query: 71 RERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRRAAVEEKR 128
RE+ E+R++++ +E E++E+ R+ E+ EE+ + LEE Q +E + VEEK
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457
Query: 129 RQ-----RLEEDK-ERHEAVVRRTMERSQKP----KQKHNRW 160
++ + +E+K +R E ++ E++ + KQ+ W
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499
Score = 38.5 bits (88), Expect = 0.023
Identities = 26/102 (25%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEER 119
R +++ E+ E+E ++ +E E+EE+ R+ EK EE+ + +E+ Q++E
Sbjct: 329 RQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE 388
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK-PKQKHNRW 160
EEK R++ E+ +E+ ++ E+ +K +Q+ W
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMW 430
Score = 38.1 bits (87), Expect = 0.030
Identities = 26/98 (26%), Positives = 53/98 (54%), Gaps = 5/98 (5%)
Query: 62 RVDDRQRLARERREE---REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
++ +++ RE+ E+ +E+++ ++ E+EE + EK E+ +KR E+ ++E+
Sbjct: 354 KIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEK 413
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ R E+ R Q EE+ R E +R E Q ++K
Sbjct: 414 KMREQDEKIREQ--EEEMWRQEEKIRELEEMMQDQEEK 449
Score = 38.1 bits (87), Expect = 0.030
Identities = 27/94 (28%), Positives = 51/94 (54%), Gaps = 11/94 (11%)
Query: 73 RREEREKQLAAR--EIVW------LEREERARQHYEK--HLEERKKRLEEQRQKEERRRA 122
R+EE+ ++ + E +W E++E+ R+ E+ EE+ + LEE Q +E +
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLR 451
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
VEEK ++ EE + E ++R E+ Q+ ++K
Sbjct: 452 EVEEKMQEE-EEKMQEQEEKIQRQEEKIQEQEEK 484
Score = 37.0 bits (84), Expect = 0.067
Identities = 36/181 (19%), Positives = 79/181 (43%), Gaps = 43/181 (23%)
Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR 533
T +A L + + E+ +++ E +E+ L ++ E+ V + + R+
Sbjct: 196 TKERDAPSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLK--------RK 247
Query: 534 LEAEQAREKEEQLQ-------------------------------RQAEERALREREE-A 561
LE Q ++QLQ +Q EE+ R+ E+
Sbjct: 248 LERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ 307
Query: 562 ERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKK---RLEEIMKRTRRTEATDK 618
E+ ++ E+E ++RE+ E++ ++ EK ++EE+ R + K + E+I ++ + ++
Sbjct: 308 EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEE 367
Query: 619 K 619
K
Sbjct: 368 K 368
Score = 36.6 bits (83), Expect = 0.088
Identities = 27/118 (22%), Positives = 59/118 (50%), Gaps = 10/118 (8%)
Query: 53 NKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEK---------HL 103
N+ + R +++ + E+ E+E ++ +E +EE+ + EK
Sbjct: 292 NQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 104 EERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTME-RSQKPKQKHNRW 160
EE+ + EE+ +++E + EEK R++ E+ +E+ E + R+ + R Q+ K++ W
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Score = 36.6 bits (83), Expect = 0.088
Identities = 28/91 (30%), Positives = 49/91 (53%), Gaps = 12/91 (13%)
Query: 74 REEREKQLAAREIVWLEREERARQHYEKHLEE---RKKRLEEQ-----RQKEERRRAAVE 125
RE+ EK E +W +EE+ R+ EK E+ ++K++ EQ Q+EE R +
Sbjct: 377 REQDEKIQEQEEEMW-RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR---Q 432
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
E++ + LEE + E +R E+ Q+ ++K
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463
Score = 35.4 bits (80), Expect = 0.20
Identities = 20/94 (21%), Positives = 49/94 (52%)
Query: 63 VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
V+++ + E+ +E+E+++ +E E+EE+ + + +E K +E++ + +
Sbjct: 453 VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E++ Q EE +R E +R R + ++K
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK 546
Score = 35.0 bits (79), Expect = 0.25
Identities = 26/89 (29%), Positives = 52/89 (58%), Gaps = 9/89 (10%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL----EEQRQKEER 119
D R + RE+ EK E +W +EE+ R+ EK ++E+++ + E+ R++EE+
Sbjct: 346 DKMWRQEEKIREQEEKIREQEEKMW-RQEEKIREQDEK-IQEQEEEMWRQEEKIREQEEK 403
Query: 120 RRAAV---EEKRRQRLEEDKERHEAVVRR 145
R+ + E+K R++ E+ +E+ E + R+
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Score = 31.6 bits (70), Expect = 2.8
Identities = 19/90 (21%), Positives = 44/90 (48%), Gaps = 8/90 (8%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+ + + +EE EK E+EE+ ++ EK E+ +K +++ ++ + +E
Sbjct: 451 REVEEKMQEEEEKM--------QEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQE 502
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
++ R EE E ++ E+ Q+ ++K
Sbjct: 503 EKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 77.0 bits (188), Expect = 6e-14
Identities = 46/138 (33%), Positives = 88/138 (63%), Gaps = 6/138 (4%)
Query: 489 LAREQREKEER-ERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQ 547
L ++Q EK R E + QE+ E+ +EL R EE+ R+EE+ E E+ RE+E+++
Sbjct: 291 LNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQE-EKIREQEDKMW 349
Query: 548 RQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREEQERLERKKRLEE 605
RQ E+ +RE+EE R Q +K +E ++RE+ E+++++ E+ +++EE+ R + +KR E+
Sbjct: 350 RQEEK--IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEK 407
Query: 606 IMKRTRRTEATDKKTSDQ 623
+ ++ ++ D+K +Q
Sbjct: 408 MWRQEKKMREQDEKIREQ 425
Score = 70.1 bits (170), Expect = 7e-12
Identities = 49/155 (31%), Positives = 92/155 (59%), Gaps = 14/155 (9%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREEL---AQRVAEERTTR-----RE 528
EE R EK R E+ ++E + REQ+E +++ EE+ +++ E+ R R+
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQ 411
Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQERE 586
E+ R + E+ RE+EE++ RQ E+ +RE EE + Q +K E E +++EE E+++++ E
Sbjct: 412 EKKMREQDEKIREQEEEMWRQEEK--IRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEE 469
Query: 587 KHFQREE--QERLERKKRLEEIMKRTRRTEATDKK 619
K ++EE QE+ E+ R E+++K+ + ++K
Sbjct: 470 KIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEK 504
Score = 68.2 bits (165), Expect = 3e-11
Identities = 48/142 (33%), Positives = 86/142 (60%), Gaps = 11/142 (7%)
Query: 477 EEATRLLAEKRRLAREQREKEERER----REQEE---LERQKREELAQRVAEERTTRRE- 528
EE R EKR+ ++EK+ RE+ REQEE + +K EL + + ++ RE
Sbjct: 394 EEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREV 453
Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKH 588
EE + E E+ +E+EE++QRQ EE+ + E+ R ++ ++E ++ E+ E++ ++ EK
Sbjct: 454 EEKMQEEEEKMQEQEEKIQRQ-EEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Query: 589 FQREE--QERLERKKRLEEIMK 608
+++EE QE+ E+ +R EE M+
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMR 534
Score = 67.8 bits (164), Expect = 4e-11
Identities = 40/137 (29%), Positives = 85/137 (62%), Gaps = 12/137 (8%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ ++ ++ ++ R++ + E+E + +E+ ++ R+E R EE+ +EE+ R E
Sbjct: 315 EQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQE- 373
Query: 537 EQAREKEEQLQRQAEE-----RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
E+ RE++E++Q Q EE +RE+EE +R ++ +E ++RE+ E++R++ E+ +++
Sbjct: 374 EKIREQDEKIQEQEEEMWRQEEKIREQEE-KRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Query: 592 EEQERLERKKRLEEIMK 608
EE+ R LEE+M+
Sbjct: 433 EEKIR-----ELEEMMQ 444
Score = 67.8 bits (164), Expect = 4e-11
Identities = 43/151 (28%), Positives = 86/151 (56%), Gaps = 5/151 (3%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQK--REELAQRVAEERTTRREEESRRL 534
EE R EK + E+ ++E + REQEE ++K R+E R +E+ +EEE R
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
E E+ RE EE +Q Q E+ E + E ++ +E+E +++ + E+++++ EK +++E+
Sbjct: 433 E-EKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491
Query: 595 ERLERK--KRLEEIMKRTRRTEATDKKTSDQ 623
+ E K ++ E++ ++ + ++K +Q
Sbjct: 492 LKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQ 522
Score = 63.9 bits (154), Expect = 5e-10
Identities = 38/141 (26%), Positives = 82/141 (58%), Gaps = 4/141 (2%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ ++ ++ ++ R++ + E+E + +E+ E+ R+E R +E+ +EEE R E
Sbjct: 336 EQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQE- 394
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE---EAERVRQEREKHFQREE 593
E+ RE+EE+ Q + + + RE+ E+ + Q+EE R E E E + Q++E+ + E
Sbjct: 395 EKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVE 454
Query: 594 QERLERKKRLEEIMKRTRRTE 614
++ E +++++E ++ +R E
Sbjct: 455 EKMQEEEEKMQEQEEKIQRQE 475
Score = 60.5 bits (145), Expect = 6e-09
Identities = 35/138 (25%), Positives = 79/138 (57%), Gaps = 4/138 (2%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEEL---ERQKREELAQRVAEERTTRREEES 531
+ EE EK R E + +E + RE EE E +K +E +++ + +E+E
Sbjct: 424 EQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEE 483
Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
+ E+ ++EE++ Q E+ +E + E+ ++ +E+E +++ + E++R++ + +Q+
Sbjct: 484 KTWRQEKLLKQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Query: 592 EEQERLERKKRLEEIMKR 609
EE+ + E++ RL+E+ +R
Sbjct: 544 EEKMQ-EQEVRLQELEER 560
Score = 60.5 bits (145), Expect = 6e-09
Identities = 41/150 (27%), Positives = 85/150 (56%), Gaps = 12/150 (8%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
D EE R + EK +E+EE+ + ++E+++RQ+ + Q EE+T R+E+ +
Sbjct: 445 DQEEKLREVEEK------MQEEEEKMQEQEEKIQRQEEKIQEQ---EEKTWRQEKLLK-- 493
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
+ E+ E+EE++ RQ E+ +E + E+ ++ + +E ++RE+ R+ Q+ EK Q +E
Sbjct: 494 QEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK-MQEQEV 552
Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E ++RL ++ ++ +++ QR
Sbjct: 553 RLQELEERLGKLGQKAELLGGAGRESGSQR 582
Score = 56.2 bits (134), Expect = 1e-07
Identities = 44/152 (28%), Positives = 84/152 (55%), Gaps = 14/152 (9%)
Query: 481 RLLAEKRRLAREQREKEERERREQEELE-----RQKREELAQRVAEERTTRREEESRRLE 535
+L E RL +E + + + + EE E Q++EE R E+ +E+E + E
Sbjct: 259 QLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKI---QEQEEKMCE 315
Query: 536 AE-QAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQRE 592
E + RE+EE++ RQ E+ + E+EE R Q K +E ++RE+ E++R++ EK R+
Sbjct: 316 QELKIREQEEKMWRQEEK--MHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK-MWRQ 372
Query: 593 EQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
E++ E+ ++++E + R E ++ ++R
Sbjct: 373 EEKIREQDEKIQEQEEEMWRQEEKIREQEEKR 404
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/166 (24%), Positives = 87/166 (52%), Gaps = 22/166 (13%)
Query: 477 EEATRLL-AEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE 535
+E RL+ +EK + ++ + + R Q L +Q+ + A R+ +E + + ++E
Sbjct: 224 QEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVE 283
Query: 536 AEQA-----REKEEQLQRQAE----------ERALREREEAERAQRQKEEEARVREEAER 580
+ +++EE++ RQ E E+ L+ RE+ E+ RQ+E ++ E+ E+
Sbjct: 284 ENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEE---KMHEQEEK 340
Query: 581 VRQEREKHFQREEQERLERKKRLEEIMKRTRRTE---ATDKKTSDQ 623
+R++ +K +++EE+ R + +K E+ K R+ E D+K +Q
Sbjct: 341 IREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQ 386
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 4/120 (3%)
Query: 60 VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEER 119
+ R +++ + E+ +EK L E +W + E+ RQ E+ + E++++++EQ +K +R
Sbjct: 471 IQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQ--EEKMWEQEEKMQEQEEKMQR 528
Query: 120 RRAAVEEK--RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPSIHSADP 177
+ + E+ R + EE + E ++ ER K QK G GS + + P
Sbjct: 529 QEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTP 588
Score = 40.0 bits (92), Expect = 0.008
Identities = 22/86 (25%), Positives = 48/86 (55%), Gaps = 1/86 (1%)
Query: 72 ERREEREKQLAAREIVWLEREERA-RQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
E+ +E+E+++ +E+ E+EE+ RQ + H +E K R +E + + + +E++ +
Sbjct: 304 EKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIR 363
Query: 131 RLEEDKERHEAVVRRTMERSQKPKQK 156
EE R E +R E+ Q+ +++
Sbjct: 364 EQEEKMWRQEEKIREQDEKIQEQEEE 389
Score = 39.7 bits (91), Expect = 0.010
Identities = 28/102 (27%), Positives = 56/102 (54%), Gaps = 12/102 (11%)
Query: 71 RERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRRAAVEEKR 128
RE+ E+R++++ +E E++E+ R+ E+ EE+ + LEE Q +E + VEEK
Sbjct: 398 REQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKM 457
Query: 129 RQ-----RLEEDK-ERHEAVVRRTMERSQKP----KQKHNRW 160
++ + +E+K +R E ++ E++ + KQ+ W
Sbjct: 458 QEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIW 499
Score = 38.5 bits (88), Expect = 0.023
Identities = 26/102 (25%), Positives = 54/102 (52%), Gaps = 3/102 (2%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEER 119
R +++ E+ E+E ++ +E E+EE+ R+ EK EE+ + +E+ Q++E
Sbjct: 329 RQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEE 388
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK-PKQKHNRW 160
EEK R++ E+ +E+ ++ E+ +K +Q+ W
Sbjct: 389 EMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMW 430
Score = 38.1 bits (87), Expect = 0.030
Identities = 26/98 (26%), Positives = 53/98 (54%), Gaps = 5/98 (5%)
Query: 62 RVDDRQRLARERREE---REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
++ +++ RE+ E+ +E+++ ++ E+EE + EK E+ +KR E+ ++E+
Sbjct: 354 KIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEK 413
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ R E+ R Q EE+ R E +R E Q ++K
Sbjct: 414 KMREQDEKIREQ--EEEMWRQEEKIRELEEMMQDQEEK 449
Score = 38.1 bits (87), Expect = 0.030
Identities = 27/94 (28%), Positives = 51/94 (54%), Gaps = 11/94 (11%)
Query: 73 RREEREKQLAAR--EIVW------LEREERARQHYEK--HLEERKKRLEEQRQKEERRRA 122
R+EE+ ++ + E +W E++E+ R+ E+ EE+ + LEE Q +E +
Sbjct: 392 RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLR 451
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
VEEK ++ EE + E ++R E+ Q+ ++K
Sbjct: 452 EVEEKMQEE-EEKMQEQEEKIQRQEEKIQEQEEK 484
Score = 37.0 bits (84), Expect = 0.067
Identities = 37/175 (21%), Positives = 77/175 (44%), Gaps = 36/175 (20%)
Query: 481 RLLAEKRRLARE-QREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQA 539
+L E+ L+ E R E +++ E Q++ L + E ++ R+LE Q
Sbjct: 194 KLTKERDALSLELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQL 253
Query: 540 REKEEQLQ-------------------------------RQAEERALREREE-AERAQRQ 567
++QLQ +Q EE+ R+ E+ E+ ++
Sbjct: 254 LLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQEQEEKM 313
Query: 568 KEEEARVREEAERVRQEREKHFQREEQERLERKK---RLEEIMKRTRRTEATDKK 619
E+E ++RE+ E++ ++ EK ++EE+ R + K + E+I ++ + ++K
Sbjct: 314 CEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEK 368
Score = 36.6 bits (83), Expect = 0.088
Identities = 27/118 (22%), Positives = 59/118 (50%), Gaps = 10/118 (8%)
Query: 53 NKPDPPPVLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEK---------HL 103
N+ + R +++ + E+ E+E ++ +E +EE+ + EK
Sbjct: 292 NQQQEEKMWRQEEKIQEQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQEDKMWRQ 351
Query: 104 EERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTME-RSQKPKQKHNRW 160
EE+ + EE+ +++E + EEK R++ E+ +E+ E + R+ + R Q+ K++ W
Sbjct: 352 EEKIREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMW 409
Score = 36.6 bits (83), Expect = 0.088
Identities = 28/91 (30%), Positives = 49/91 (53%), Gaps = 12/91 (13%)
Query: 74 REEREKQLAAREIVWLEREERARQHYEKHLEE---RKKRLEEQ-----RQKEERRRAAVE 125
RE+ EK E +W +EE+ R+ EK E+ ++K++ EQ Q+EE R +
Sbjct: 377 REQDEKIQEQEEEMW-RQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWR---Q 432
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
E++ + LEE + E +R E+ Q+ ++K
Sbjct: 433 EEKIRELEEMMQDQEEKLREVEEKMQEEEEK 463
Score = 35.4 bits (80), Expect = 0.20
Identities = 20/94 (21%), Positives = 49/94 (52%)
Query: 63 VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
V+++ + E+ +E+E+++ +E E+EE+ + + +E K +E++ + +
Sbjct: 453 VEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEKM 512
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E++ Q EE +R E +R R + ++K
Sbjct: 513 WEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEK 546
Score = 35.0 bits (79), Expect = 0.25
Identities = 26/89 (29%), Positives = 52/89 (58%), Gaps = 9/89 (10%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL----EEQRQKEER 119
D R + RE+ EK E +W +EE+ R+ EK ++E+++ + E+ R++EE+
Sbjct: 346 DKMWRQEEKIREQEEKIREQEEKMW-RQEEKIREQDEK-IQEQEEEMWRQEEKIREQEEK 403
Query: 120 RRAAV---EEKRRQRLEEDKERHEAVVRR 145
R+ + E+K R++ E+ +E+ E + R+
Sbjct: 404 RQEKMWRQEKKMREQDEKIREQEEEMWRQ 432
Score = 31.6 bits (70), Expect = 2.8
Identities = 19/90 (21%), Positives = 44/90 (48%), Gaps = 8/90 (8%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEE 126
+ + + +EE EK E+EE+ ++ EK E+ +K +++ ++ + +E
Sbjct: 451 REVEEKMQEEEEKM--------QEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQE 502
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
++ R EE E ++ E+ Q+ ++K
Sbjct: 503 EKMWRQEEKMWEQEEKMQEQEEKMQRQEEK 532
>gi|7661936 scaffold attachment factor B2 [Homo sapiens]
Length = 953
Score = 77.0 bits (188), Expect = 6e-14
Identities = 69/249 (27%), Positives = 114/249 (45%), Gaps = 35/249 (14%)
Query: 372 VKREVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAP 431
+K+E K+E K EK+P+ + K EE +E P GP +
Sbjct: 523 IKKEEKIE---KKEEKKPEDI-------------KKEEKDQDELKP-----GPTNRSRVT 561
Query: 432 APASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSAGTTDPEEATRLLAEKRRLAR 491
S + P + S S S + S+ + D + ++ EKR +
Sbjct: 562 KSGSRGMERTVVMDKSKGEPVI-----SVKTTSRSKERSSKSQDRKSESK---EKRDILS 613
Query: 492 EQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAE 551
+ KE+RER Q + ER+ RE +R E+R E +RLEA R+++ +LQR+
Sbjct: 614 FDKIKEQRERERQRQREREIRETERRREREQR-----EREQRLEAFHERKEKARLQRERL 668
Query: 552 E-RALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRT 610
+ R+R E ER +R++ E R+R E ER +++ H +REE R + + R E+ +
Sbjct: 669 QLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPG 728
Query: 611 RRTEATDKK 619
RR D++
Sbjct: 729 RRPYDLDRR 737
Score = 53.1 bits (126), Expect = 9e-07
Identities = 40/154 (25%), Positives = 73/154 (47%), Gaps = 7/154 (4%)
Query: 10 GHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQRL 69
G RG + V + + + K + S+ S+ S + S K D ++ +++
Sbjct: 564 GSRGMERTVVMDKSKGEPVISVKTTSRSKERSSKSQDRKSESKEKRDILSFDKIKEQRER 623
Query: 70 ARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE----RRRAAVE 125
R+R+ ERE + R ERE+R R+ + ERK++ QR++ + R+R E
Sbjct: 624 ERQRQREREIRETERR---REREQREREQRLEAFHERKEKARLQRERLQLECQRQRLERE 680
Query: 126 EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R+RLE ++ R E R+ ER + +++ R
Sbjct: 681 RMERERLERERMRVERERRKEQERIHREREELRR 714
Score = 45.1 bits (105), Expect = 2e-04
Identities = 42/140 (30%), Positives = 69/140 (49%), Gaps = 15/140 (10%)
Query: 20 SETAPDSYKVQDKKNASSRPASAISG---QNNNHSGNKPDPPPVLRVDDRQRLARERREE 76
S + S K QD+K+ S +S + + +R +R+R RE+R E
Sbjct: 589 SRSKERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRR-EREQR-E 646
Query: 77 REKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQRLEEDK 136
RE++L A + ER+E+AR L+ + +LE QRQ+ ER R E R+R+ ++
Sbjct: 647 REQRLEA----FHERKEKAR------LQRERLQLECQRQRLERERMERERLERERMRVER 696
Query: 137 ERHEAVVRRTMERSQKPKQK 156
ER + R ER + +Q+
Sbjct: 697 ERRKEQERIHREREELRRQQ 716
Score = 43.5 bits (101), Expect = 7e-04
Identities = 37/159 (23%), Positives = 71/159 (44%), Gaps = 19/159 (11%)
Query: 19 RSETAPDSYKVQDKKNASSRPA---------SAISGQNNNHSGNKPDPPPVLRVD----- 64
+ E P+ K ++K +P S G +K PV+ V
Sbjct: 532 KEEKKPEDIKKEEKDQDELKPGPTNRSRVTKSGSRGMERTVVMDKSKGEPVISVKTTSRS 591
Query: 65 -DRQRLARERREEREKQ---LAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
+R +++R+ E +++ L+ +I ER RQ + E ++R EQR++E+R
Sbjct: 592 KERSSKSQDRKSESKEKRDILSFDKIKEQRERERQRQREREIRETERRREREQREREQRL 651
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
A E K + RL+ ++ + E R+ +ER + +++ R
Sbjct: 652 EAFHERKEKARLQRERLQLEC-QRQRLERERMERERLER 689
Score = 35.8 bits (81), Expect = 0.15
Identities = 23/80 (28%), Positives = 44/80 (55%), Gaps = 4/80 (5%)
Query: 65 DRQRLARERRE-EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
++ RL RER + E ++Q RE + ER ER R E+ + ++R+ +R++ R++
Sbjct: 659 EKARLQRERLQLECQRQRLERERMERERLERERMRVERERRKEQERIHREREELRRQQEQ 718
Query: 124 V---EEKRRQRLEEDKERHE 140
+ +E+R R D +R +
Sbjct: 719 LRYEQERRPGRRPYDLDRRD 738
Score = 31.6 bits (70), Expect = 2.8
Identities = 19/70 (27%), Positives = 33/70 (47%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
+R+RL RER ++ +E + EREE RQ + E+ ++ + R A
Sbjct: 683 ERERLERERMRVERERRKEQERIHREREELRRQQEQLRYEQERRPGRRPYDLDRRDDAYW 742
Query: 125 EEKRRQRLEE 134
E +R +E+
Sbjct: 743 PEGKRVAMED 752
>gi|50513245 chromatin assembly factor 1, subunit A (p150) [Homo
sapiens]
Length = 956
Score = 76.6 bits (187), Expect = 8e-14
Identities = 56/186 (30%), Positives = 96/186 (51%), Gaps = 20/186 (10%)
Query: 409 EATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPSSTVNASASVK 468
E+ V E P E V + + +P+S +P PAP P + P+ST + K
Sbjct: 268 ESEVLESFPEEDSV--LSHSSLSSPSSTSSPEGPPAP-PKQHSSTSPFPTSTPLRRITKK 324
Query: 469 TSAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRRE 528
G+T+ + RL ++ RL ++ + + ERE E++K +E A+R EE ++E
Sbjct: 325 FVKGSTEKNKL-RLQRDQERLGKQLKLRAERE-------EKEKLKEEAKRAKEEAKKKKE 376
Query: 529 EESRRLEAEQAREKEEQLQRQAEERALREREEAERAQ---------RQKEEEARVREEAE 579
EE E E+ ++E+ + +AE++ L+E ER + R+KEEE R+REE +
Sbjct: 377 EEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEK 436
Query: 580 RVRQER 585
R++ E+
Sbjct: 437 RIKAEK 442
Score = 75.9 bits (185), Expect = 1e-13
Identities = 59/212 (27%), Positives = 111/212 (52%), Gaps = 12/212 (5%)
Query: 399 KGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPASAPAPASAPAPAPVPTPAMVSAPS 458
KG+ P+V +++ P + + PA P + S P V + + +S+PS
Sbjct: 234 KGKVPMVVLQDILAVR--PPQIKSLPATPQGKNMTPESEVLESFPEEDSVLSHSSLSSPS 291
Query: 459 STVNAS---ASVKTSAGTTDPEEATRLLAEKRRLAREQREKEE-RERREQEELERQKREE 514
ST + A K + T+ +T L ++ + EK + R +R+QE L +Q
Sbjct: 292 STSSPEGPPAPPKQHSSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQ---- 347
Query: 515 LAQRVAEERTTRREEESRRLEAEQAREKEEQLQ-RQAEERALREREEAERAQRQKEEEAR 573
L R E + +EE++R + E ++KEE+ + ++ E R RE++E E+A++Q+ +E R
Sbjct: 348 LKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEER 407
Query: 574 VREEAERVRQEREKHFQREEQERL-ERKKRLE 604
+E E + + E+ ++EE++RL E +KR++
Sbjct: 408 RKERQEALEAKLEEKRKKEEEKRLREEEKRIK 439
Score = 52.4 bits (124), Expect = 2e-06
Identities = 32/98 (32%), Positives = 58/98 (59%), Gaps = 8/98 (8%)
Query: 65 DRQRLARE---RREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
D++RL ++ R E EK+ E + E + ++ EK L+E+++R E+R+K+E+ +
Sbjct: 340 DQERLGKQLKLRAEREEKEKLKEEAKRAKEEAKKKKEEEKELKEKERR--EKREKDEKEK 397
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
A EK+R + E KER EA+ + E+ +K ++K R
Sbjct: 398 A---EKQRLKEERRKERQEALEAKLEEKRKKEEEKRLR 432
Score = 47.0 bits (110), Expect = 6e-05
Identities = 31/102 (30%), Positives = 57/102 (55%), Gaps = 14/102 (13%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR-- 121
+++++L E + +E+ +E E+E + ++ EK ++ K++ E+QR KEERR+
Sbjct: 355 EEKEKLKEEAKRAKEEAKKKKEE---EKELKEKERREKREKDEKEKAEKQRLKEERRKER 411
Query: 122 -----AAVEEKRR----QRLEEDKERHEAVVRRTMERSQKPK 154
A +EEKR+ +RL E+++R +A QKPK
Sbjct: 412 QEALEAKLEEKRKKEEEKRLREEEKRIKAEKAEITRFFQKPK 453
Score = 45.1 bits (105), Expect = 2e-04
Identities = 23/76 (30%), Positives = 45/76 (59%)
Query: 66 RQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE 125
+++ RE+RE+ EK+ A ++ + ER + ++ E LEE++K+ EE+R +EE +R E
Sbjct: 382 KEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLEEKRKKEEEKRLREEEKRIKAE 441
Query: 126 EKRRQRLEEDKERHEA 141
+ R + + +A
Sbjct: 442 KAEITRFFQKPKTPQA 457
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 76.3 bits (186), Expect = 1e-13
Identities = 43/144 (29%), Positives = 76/144 (52%), Gaps = 8/144 (5%)
Query: 485 EKRRLAREQREKE-ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKE 543
E++R R+KE ERE+ QE ER+++ E + + + R E R E E E++
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERK 225
Query: 544 EQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ---EREKHFQREEQERLERK 600
Q R+ + + ERE ++A+R++ E + ER R+ +R++ +++E+ER +
Sbjct: 226 RQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR 285
Query: 601 KRLEEIMKRTRRTEATDKKTSDQR 624
KR +RT R T++K QR
Sbjct: 286 KR----QRRTERDRETERKRERQR 305
Score = 75.9 bits (185), Expect = 1e-13
Identities = 43/129 (33%), Positives = 70/129 (54%), Gaps = 7/129 (5%)
Query: 492 EQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAE------QAREKEEQ 545
E++ + +RER Q + ER++ ++ + A ER T R++E R + +E+E Q
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQ 282
Query: 546 LQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEE 605
R+ + R R+RE + +RQ+E E R RE + +ERE+ +RE Q ER + E
Sbjct: 283 TDRKRQRRTERDRETERKRERQRERE-RERERNRKRERERERERERERQRETERDREKER 341
Query: 606 IMKRTRRTE 614
KR R+TE
Sbjct: 342 ERKRKRQTE 350
Score = 73.9 bits (180), Expect = 5e-13
Identities = 50/146 (34%), Positives = 77/146 (52%), Gaps = 7/146 (4%)
Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAE 537
E R +R RE+ K ERER + E ERQ+ E + ER +R+ E ++ E
Sbjct: 298 ERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTE---MDRE 354
Query: 538 QAREKEEQLQRQAEERALREREEAERAQRQKEEEARVRE---EAERVRQ-EREKHFQREE 593
+ R+ + +RQAE RERE ++ R++EE R R+ + ER RQ E+++ QRE
Sbjct: 355 RNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRET 414
Query: 594 QERLERKKRLEEIMKRTRRTEATDKK 619
+++ ER+K E R R E +K
Sbjct: 415 EKQREREKDRESERGRERGREREKQK 440
Score = 73.2 bits (178), Expect = 8e-13
Identities = 47/156 (30%), Positives = 79/156 (50%), Gaps = 12/156 (7%)
Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEE---SRRL 534
E R R R++ ++ERER+ E +RQ+ +E ++ ER T RE E R+
Sbjct: 84 EKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQT 143
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
+ ++ RE++ +++ E + RER+ RQKE E RE+ + R+ERE+ ++E +
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQRQTERNRQKERE---REKNRQERRERERQREKENK 200
Query: 595 ------ERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
ER ++R E T R TD++ QR
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRERDRQR 236
Score = 72.4 bits (176), Expect = 1e-12
Identities = 43/144 (29%), Positives = 78/144 (54%), Gaps = 7/144 (4%)
Query: 486 KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK--E 543
+R+ RE+ + E+ER Q+E ER+ E +R + +T + E R+ +AE+ RE+ +
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETERE-GERGRDRQTDGQRERERQRDAEKERERQTD 164
Query: 544 EQLQRQAEERALRERE----EAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
+ QRQ E +ERE ER +R+++ E + E + RE+ +RE + ER
Sbjct: 165 RERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETER 224
Query: 600 KKRLEEIMKRTRRTEATDKKTSDQ 623
K++ + R R+TE +K +++
Sbjct: 225 KRQTDRERDRQRKTEREREKQAER 248
Score = 72.0 bits (175), Expect = 2e-12
Identities = 45/138 (32%), Positives = 74/138 (53%), Gaps = 9/138 (6%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAE---ERTTRREEES---RRLEAEQ 538
E+ R +REK +ERRE+E +R+K + R +E ER RE E+ R+ + ++
Sbjct: 172 ERNRQKEREREKNRQERRERER-QREKENKTEDRHSERGRERERERETETETERKRQTDR 230
Query: 539 AREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR--QEREKHFQREEQER 596
R+++ + +R+ E++A RER +R KE E + +R R +ERE+ R+ Q R
Sbjct: 231 ERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRR 290
Query: 597 LERKKRLEEIMKRTRRTE 614
ER + E +R R E
Sbjct: 291 TERDRETERKRERQRERE 308
Score = 72.0 bits (175), Expect = 2e-12
Identities = 40/146 (27%), Positives = 75/146 (51%), Gaps = 2/146 (1%)
Query: 484 AEKRRLAREQREK-EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
AE+ R + + E+ +ERER + +R +R++ +R + + RR E R E ++ R++
Sbjct: 246 AERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQR 305
Query: 543 EEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR-QEREKHFQREEQERLERKK 601
E + +R+ + RERE +RQ+E E +E ER R ++ E +R Q E ++
Sbjct: 306 ERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR 365
Query: 602 RLEEIMKRTRRTEATDKKTSDQRNGD 627
+ E +R R + + ++R D
Sbjct: 366 QAERERERERERDRQSAREREERERD 391
Score = 70.9 bits (172), Expect = 4e-12
Identities = 47/156 (30%), Positives = 79/156 (50%), Gaps = 16/156 (10%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEE-----SRRLEAEQA 539
E+ R R++ ++ER Q + +RQ+R E + +R +RE E +R+ E E+
Sbjct: 263 ERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERE 322
Query: 540 REKEEQLQRQAEERALREREEAERAQ--------RQKEEEARVREEAERVRQ---EREKH 588
RE+E + QR+ E +ERE + Q RQ E R + E ER R+ +R+
Sbjct: 323 RERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSA 382
Query: 589 FQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
+REE+ER + R +E ++T + ++T QR
Sbjct: 383 REREERERDRDRDRQKERERQTEKDRDGQRETEKQR 418
Score = 70.5 bits (171), Expect = 5e-12
Identities = 49/157 (31%), Positives = 80/157 (50%), Gaps = 8/157 (5%)
Query: 475 DPEEATRLLAEKRRLAREQREKE-ERERREQEELERQKREELAQRVAEERTTRREEESRR 533
D E R +RR + Q E+E +R+R + E +R ++ + + +R RE ++ R
Sbjct: 52 DDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDR 111
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQR--QKEEEARVREEAERVRQ---EREKH 588
E ++ REKE Q++ E RE E Q Q+E E + E ER RQ ER++
Sbjct: 112 -ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170
Query: 589 FQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
+R Q+ ER+K +E +R R+ E + KT D+ +
Sbjct: 171 TERNRQKEREREKNRQERRERERQRE-KENKTEDRHS 206
Score = 69.7 bits (169), Expect = 9e-12
Identities = 40/151 (26%), Positives = 74/151 (49%), Gaps = 1/151 (0%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
D ++ R ++R RE+R+ E R++E + R R E + R +E R+
Sbjct: 50 DGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQT 109
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQ 594
+ E+ R++E++ RQ E ERE ER + ++ + R RE +ERE+ RE Q
Sbjct: 110 DRERDRQREKERNRQKERERETERE-GERGRDRQTDGQRERERQRDAEKERERQTDRERQ 168
Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
+ ER ++ E ++ R+ ++ ++ N
Sbjct: 169 RQTERNRQKEREREKNRQERRERERQREKEN 199
Score = 69.7 bits (169), Expect = 9e-12
Identities = 46/160 (28%), Positives = 81/160 (50%), Gaps = 11/160 (6%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQK---REELAQRVAEERTTRREEES 531
D + R +R+ R+++ + ER+R + + ERQ+ RE R E R E
Sbjct: 269 DRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERE 328
Query: 532 RRLEAEQAREKEEQLQRQAEERALRER------EEAERAQRQKEEEARVREEAERVRQER 585
R+ E E+ REKE + +R+ + RER E +A+R++E E ++ R R+ER
Sbjct: 329 RQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREER 388
Query: 586 EKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRN 625
E+ R+ Q+ ER+++ E+ R TE ++ D+ +
Sbjct: 389 ERDRDRDRQK--ERERQTEKDRDGQRETEKQREREKDRES 426
Score = 68.9 bits (167), Expect = 2e-11
Identities = 40/138 (28%), Positives = 75/138 (54%), Gaps = 5/138 (3%)
Query: 490 AREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQ 549
A + + ++RER Q+E ER++ + +R + + RR E+ R + ++ RE++ +++
Sbjct: 45 AHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKE 104
Query: 550 AEERALRERE---EAERAQRQKEEEARVREEAERVR-QEREKHFQREEQERLERKKRLEE 605
E + RER+ E ER RQKE E E ER R ++ + +RE Q E+++ +
Sbjct: 105 RERQTDRERDRQREKER-NRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQT 163
Query: 606 IMKRTRRTEATDKKTSDQ 623
+R R+TE +K ++
Sbjct: 164 DRERQRQTERNRQKERER 181
Score = 68.2 bits (165), Expect = 3e-11
Identities = 49/164 (29%), Positives = 80/164 (48%), Gaps = 13/164 (7%)
Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR 533
TD E + E+ R +RE E R ++ +RE QR AE+ R+ + R+
Sbjct: 109 TDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQ 168
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQ---------RQKEEEARVREEAERVRQ- 583
+ E+ R+KE + ++ +ER RER+ + + R++E E E ER RQ
Sbjct: 169 RQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQT 228
Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGD 627
+RE+ QR+ + ER+K+ E R TE DK+ +R+ D
Sbjct: 229 DRERDRQRKTER--EREKQAERERASERETE-RDKERERERDRD 269
Score = 67.0 bits (162), Expect = 6e-11
Identities = 49/143 (34%), Positives = 77/143 (53%), Gaps = 13/143 (9%)
Query: 491 REQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQA 550
RE++ E+ER Q + ERQ++ E ++ ER R+E R E E+ REKE + + +
Sbjct: 149 RERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQE---RRERERQREKENKTEDRH 205
Query: 551 EERALRERE-------EAERAQRQKEEEARVRE-EAERVRQ-EREKHFQREEQERLERKK 601
ER RERE E ER ++ E R R+ E ER +Q ERE+ +RE + ER++
Sbjct: 206 SERG-RERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERER 264
Query: 602 RLEEIMKRTRRTEATDKKTSDQR 624
+ R RR + +++T +R
Sbjct: 265 ERDRDRDRDRRQKERERQTDRKR 287
Score = 65.9 bits (159), Expect = 1e-10
Identities = 45/145 (31%), Positives = 75/145 (51%), Gaps = 7/145 (4%)
Query: 486 KRRLAREQREKEERERREQE---ELERQKREELAQRVAEERTTRREEESRRLEAEQAREK 542
++R +RE+E +RE E E ER+++ + + ER + E RR +AE+ RE+
Sbjct: 315 RKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRR-QAERERER 373
Query: 543 EEQLQRQ-AEERALREREEAERAQRQKEEEARVREEAER-VRQEREKHFQREEQERLERK 600
E + RQ A ER RER+ Q+++E + + +R ++RE+ RE + ER
Sbjct: 374 ERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERG 433
Query: 601 KRLEEIMKRTR-RTEATDKKTSDQR 624
+ E+ R R R TD++ QR
Sbjct: 434 REREKQKGRERDRERQTDRQAGRQR 458
Score = 64.3 bits (155), Expect = 4e-10
Identities = 45/142 (31%), Positives = 77/142 (54%), Gaps = 13/142 (9%)
Query: 485 EKRRLAREQREKE-ERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQA--RE 541
EK R R +RE++ E+E + ++ + RE +R E T R+ + R + ++ RE
Sbjct: 182 EKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERE 241
Query: 542 KEEQLQRQ-AEERAL-----RERE---EAERAQRQKEEEARVREEAERVRQEREKHFQRE 592
+E+Q +R+ A ER RERE + +R +RQKE E + + +R R ER++ +R+
Sbjct: 242 REKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR-RTERDRETERK 300
Query: 593 EQERLERKKRLEEIMKRTRRTE 614
+ + ER++ E KR R E
Sbjct: 301 RERQRERERERERNRKRERERE 322
Score = 60.8 bits (146), Expect = 4e-09
Identities = 37/125 (29%), Positives = 63/125 (50%), Gaps = 3/125 (2%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
+E R + + RE+ + RE R Q E ER++ E ++ A ER R + R +
Sbjct: 339 KERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQK 398
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQER 596
E+ R+ E+ Q E RERE+ ++R +E R RE ++ +ER++ Q + Q
Sbjct: 399 ERERQTEKDRDGQRETEKQREREKDRESERGRE---RGREREKQKGRERDRERQTDRQAG 455
Query: 597 LERKK 601
+RK+
Sbjct: 456 RQRKR 460
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/182 (26%), Positives = 81/182 (44%), Gaps = 8/182 (4%)
Query: 485 EKRRLAREQREKE-ERERREQEELERQKREELAQ---RVAE-ERTTRREEESRRLEAEQA 539
E++R REKE ER+R+ Q E++R++ + + R AE ER RE + + +
Sbjct: 328 ERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREE 387
Query: 540 REKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE-REKHFQREEQERLE 598
RE++ RQ E E++ + + +K+ E E+ER R+ RE+ Q+ + E
Sbjct: 388 RERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRERDRE 447
Query: 599 RKKRLEEIMKRTRRTEATDKKTSDQRNGDIAK--GALTGGTEVSALPCTTNAPGNGKPVG 656
R+ + +R R T + R+G + T G + P A P G
Sbjct: 448 RQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSPEDPKAASTRFPWG 507
Query: 657 SP 658
P
Sbjct: 508 RP 509
Score = 53.1 bits (126), Expect = 9e-07
Identities = 33/109 (30%), Positives = 56/109 (51%), Gaps = 1/109 (0%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
D E + E RR A +RE ERER Q ER++RE R ++ R+ E+ R
Sbjct: 352 DRERNRQTGREGRRQAERERE-RERERDRQSAREREERERDRDRDRQKERERQTEKDRDG 410
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQ 583
+ E +++E + R++E R RE ++ R+++ E + +A R R+
Sbjct: 411 QRETEKQREREKDRESERGRERGREREKQKGRERDRERQTDRQAGRQRK 459
Score = 46.6 bits (109), Expect = 8e-05
Identities = 32/109 (29%), Positives = 54/109 (49%), Gaps = 12/109 (11%)
Query: 65 DRQRLARERREEREKQLAAREIVWLERE---------ERARQHYEKHLEERKKRLEEQRQ 115
DR++ RER+ +R++Q ER+ ER R + ER++ E QR+
Sbjct: 273 DRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRE 332
Query: 116 KEERRRAAVEEKRRQRLEEDKERHEAV---VRRTMERSQKPKQKHNRWS 161
E R E KR+++ E D+ER+ RR ER ++ +++ +R S
Sbjct: 333 TERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS 381
Score = 43.5 bits (101), Expect = 7e-04
Identities = 32/101 (31%), Positives = 52/101 (51%), Gaps = 10/101 (9%)
Query: 62 RVDDRQRLA---RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
R +RQR A RER+ +RE+Q ER + + EK+ +ER++R E QR+KE
Sbjct: 147 RERERQRDAEKERERQTDRERQRQT------ERNRQKEREREKNRQERRER-ERQREKEN 199
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ E+ R+R E + E +R +R + ++K R
Sbjct: 200 KTEDRHSERGRERERERETETETERKRQTDRERDRQRKTER 240
Score = 43.5 bits (101), Expect = 7e-04
Identities = 31/98 (31%), Positives = 53/98 (54%), Gaps = 8/98 (8%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R DR+R R+R+ ERE++ A ERE + E+ E + R ++RQKE R+
Sbjct: 226 RQTDRER-DRQRKTEREREKQAERERASERE--TERDKERERERDRDRDRDRRQKERERQ 282
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ KR++R E D+E +R +R ++ +++ NR
Sbjct: 283 T--DRKRQRRTERDRETER---KRERQRERERERERNR 315
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/94 (26%), Positives = 49/94 (52%), Gaps = 5/94 (5%)
Query: 64 DDRQRL-ARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
DDR+R +ER REK+ RE +R+ R+ ++H +R + E QR +E+ R
Sbjct: 52 DDRERNRQKERERRREKRQTERE---TDRKRERRREKDRH-RKRDRHRERQRDREKERER 107
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ +R ++ E+++ R + R T ++ + +
Sbjct: 108 QTDRERDRQREKERNRQKERERETEREGERGRDR 141
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/102 (25%), Positives = 52/102 (50%), Gaps = 4/102 (3%)
Query: 62 RVDDRQRLA-RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERR 120
R DRQR RER ++ E++ A+ ++E + ++ + R+K E Q ++ +R
Sbjct: 230 RERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289
Query: 121 RAAVE---EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R + E++R+R E + E +R ER ++ +++ R
Sbjct: 290 RTERDRETERKRERQRERERERERNRKRERERERERERERQR 331
Score = 42.0 bits (97), Expect = 0.002
Identities = 34/157 (21%), Positives = 64/157 (40%), Gaps = 16/157 (10%)
Query: 8 GDGHRGGDGAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVDDRQ 67
G H+ DG R + + +K + R + ++ + D +
Sbjct: 43 GQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHR-------KRDRHR 95
Query: 68 RLARERREEREKQLAAREIVWLEREERARQHYEKHLEE-----RKKRLEEQRQKEERRRA 122
R+R +ERE+Q E+E ++ E+ E R ++ + QR++E +R A
Sbjct: 96 ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
EK R+R + D+ER R + ++ K + R
Sbjct: 156 ---EKERER-QTDRERQRQTERNRQKEREREKNRQER 188
Score = 41.2 bits (95), Expect = 0.004
Identities = 40/165 (24%), Positives = 66/165 (40%), Gaps = 23/165 (13%)
Query: 9 DGHRGGD----GAVRSETAPDSYKVQDKKNASSRPASAISGQNNNHSGNKPDPPPVLRVD 64
+G RG D G E D+ K ++++ R + K +
Sbjct: 134 EGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREK---------N 184
Query: 65 DRQRLARERREEREKQLAAREIV-WLERE---------ERARQHYEKHLEERKKRLEEQR 114
++R RER+ E+E + R ERE ER RQ + +RK E ++
Sbjct: 185 RQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREK 244
Query: 115 QKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
Q E R + E +R + E +++R RR ER ++ +K R
Sbjct: 245 QAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQR 289
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/112 (22%), Positives = 50/112 (44%), Gaps = 3/112 (2%)
Query: 528 EEESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREK 587
+E RR QA + + R+ + RER +R ++ + R R + ++R++
Sbjct: 34 QESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDR 93
Query: 588 HFQREEQERLERKKRLEEIMKRTRRTEATDKKTSD---QRNGDIAKGALTGG 636
H +R+ ER+++ + R R E +K + +R G+ + T G
Sbjct: 94 HRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDG 145
Score = 40.8 bits (94), Expect = 0.005
Identities = 25/86 (29%), Positives = 39/86 (45%)
Query: 71 RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
RER ERE+Q ERE + ++ E E ++ E R++ ER R E+ RQ
Sbjct: 321 RERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQ 380
Query: 131 RLEEDKERHEAVVRRTMERSQKPKQK 156
E +ER R + ++ +K
Sbjct: 381 SAREREERERDRDRDRQKERERQTEK 406
Score = 39.3 bits (90), Expect = 0.014
Identities = 33/103 (32%), Positives = 49/103 (47%), Gaps = 13/103 (12%)
Query: 62 RVDDRQR-LARERREEREKQLAAREIVWLERE-----ERARQHYEKHLEERKKRLEEQRQ 115
R DRQR R R++ERE++ +R+ ER RQ + ER+ E QRQ
Sbjct: 111 RERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170
Query: 116 KEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHN 158
E R +K R+R + +ER E R E+ K + +H+
Sbjct: 171 TERNR-----QKEREREKNRQERRER--ERQREKENKTEDRHS 206
Score = 39.3 bits (90), Expect = 0.014
Identities = 24/95 (25%), Positives = 48/95 (50%), Gaps = 2/95 (2%)
Query: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
+R+R A ER ER+K+ +R+ R ++ E+ + +++R E+ ++ ER+R
Sbjct: 247 ERER-ASERETERDKERERERDRDRDRDRRQKER-ERQTDRKRQRRTERDRETERKRERQ 304
Query: 125 EEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E+ R+R K E R ER ++ ++ +
Sbjct: 305 RERERERERNRKRERERERERERERQRETERDREK 339
Score = 39.3 bits (90), Expect = 0.014
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 1/95 (1%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR 121
R +RQR RER ER ++ ERE + ++ E +KR + ER R
Sbjct: 299 RKRERQR-ERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
E RRQ E + E + ER ++ + +
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDR 392
Score = 38.9 bits (89), Expect = 0.018
Identities = 18/89 (20%), Positives = 40/89 (44%)
Query: 71 RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
RER E E + + ER+ + + E+ + ++R E+ + ++ R ++ R
Sbjct: 212 RERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRD 271
Query: 131 RLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R KER R+ R+++ ++ +
Sbjct: 272 RDRRQKERERQTDRKRQRRTERDRETERK 300
Score = 38.1 bits (87), Expect = 0.030
Identities = 26/104 (25%), Positives = 51/104 (49%), Gaps = 7/104 (6%)
Query: 535 EAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVR-QEREKHFQREE 593
+ E+ R+KE + +R+ + + RE + +R+K+ + ER R +E+E+ Q +
Sbjct: 53 DRERNRQKERERRRE-KRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDR 111
Query: 594 QERLERKKRLEEIMKRTRRTE-----ATDKKTSDQRNGDIAKGA 632
+ +R+K +R R TE D++T QR + + A
Sbjct: 112 ERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155
Score = 38.1 bits (87), Expect = 0.030
Identities = 42/170 (24%), Positives = 75/170 (44%), Gaps = 11/170 (6%)
Query: 62 RVDDRQR-LARERREEREKQLAAREIVWLER-----EERARQHYEKHLEERKKRLEEQRQ 115
R +RQR R+R +ERE++ + + ER E RQ + ER++ + R+
Sbjct: 325 RERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSARE 384
Query: 116 KEERRRAAVEEKRRQR---LEEDKE-RHEAVVRRTMERSQKPKQKHNRWSWGGSLHGSPS 171
+EER R +++++R E+D++ + E +R E+ ++ ++ R G
Sbjct: 385 REERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKGRER 444
Query: 172 IHSADPDRRSVSTMNLSK-YVDPVISKRLSSSSATLLNSPDRARRLQLSP 220
DR++ S YV+P S + N P R R + SP
Sbjct: 445 DRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRPTRGIRWKSSP 494
Score = 37.0 bits (84), Expect = 0.067
Identities = 27/101 (26%), Positives = 50/101 (49%), Gaps = 10/101 (9%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR---LEEQRQKEE 118
R +R+R R+R ERE++ RE ER+ + EK E ++KR ++ +R ++
Sbjct: 307 RERERER-NRKRERERERE---RE---RERQRETERDREKERERKRKRQTEMDRERNRQT 359
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R + +R + E +++R A R ER + ++ R
Sbjct: 360 GREGRRQAERERERERERDRQSAREREERERDRDRDRQKER 400
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 76.3 bits (186), Expect = 1e-13
Identities = 44/151 (29%), Positives = 90/151 (59%), Gaps = 10/151 (6%)
Query: 483 LAEKRRLAREQREK----EERERREQEELERQKREELAQRVAEERTTRREEESRRL--EA 536
L E+ REQ EK E+R R +++EL Q++E Q+ E+ + +E+ ++ +
Sbjct: 264 LREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQE 323
Query: 537 EQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQE----REKHFQRE 592
E+ RE+EE++ RQ E +E++ E+ Q+ +++E R+ E+ ER+R++ RE+ E
Sbjct: 324 EKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWE 383
Query: 593 EQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
++E+++ ++R+ E K+ R E T ++ ++
Sbjct: 384 QEEKMQEEERIREREKKMREEEETMREQEEK 414
Score = 74.3 bits (181), Expect = 4e-13
Identities = 44/162 (27%), Positives = 94/162 (58%), Gaps = 17/162 (10%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ ++ ++ ++ R++ E+E + +E+ E+ +R+E +R+ E+ RE+E E
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQE--KRLREQEKELREQEKELREQ 302
Query: 537 EQAREKEEQLQRQAE-----ERALREREEAERAQRQK--EEEARVREEAERVRQEREKHF 589
++ RE+EEQ+Q Q E E +RE+EE Q ++ E+E ++RE+ +++R + E+ +
Sbjct: 303 KKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMW 362
Query: 590 Q-----REEQERLERKKRL---EEIMKRTRRTEATDKKTSDQ 623
+ RE++ER+ ++++ EE M+ R +KK ++
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404
Score = 72.4 bits (176), Expect = 1e-12
Identities = 50/153 (32%), Positives = 82/153 (53%), Gaps = 11/153 (7%)
Query: 478 EATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAE 537
E + L E+ + REQ++ E+E + QE+ E+ +E R EE+ R+EE R E E
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEE--RLWEQE 344
Query: 538 QAREKEEQLQRQAEERA------LREREEAERAQRQKEEEARVREEAERVRQEREKHFQR 591
+ ++EQ R EER LRE+EE R Q + E+ +E ER+R EREK +
Sbjct: 345 KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIR-EREKKMRE 403
Query: 592 EEQERLERKKRLEEIMKRTRRTEATDKKTSDQR 624
EE+ E+++++++ + E +K+ QR
Sbjct: 404 EEETMREQEEKMQK--QEENMWEQEEKEWQQQR 434
Score = 71.6 bits (174), Expect = 2e-12
Identities = 46/153 (30%), Positives = 94/153 (61%), Gaps = 10/153 (6%)
Query: 473 TTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESR 532
T D EE R E+R RE++ +EE E ++E + Q++EE R EE+ +EE+ +
Sbjct: 549 TWDQEEKMR--EEERMREREKKMREEEEMMREQEEKMQEQEE-KMREQEEKMWEQEEKMQ 605
Query: 533 RLEAEQAREKEEQLQRQAEERALREREEA--ERAQRQKEEEARVREEAERVRQEREKHFQ 590
E E+ E+EE++ Q EE ++E+EE E+ ++ +E+E ++ E+ E++R++ EK
Sbjct: 606 EQE-EKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK--M 662
Query: 591 REEQERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
RE++E+++ ++ E++ ++ + + ++K +Q
Sbjct: 663 REQEEKMQGQE--EKMREQEEKMQGQEEKMREQ 693
Score = 71.2 bits (173), Expect = 3e-12
Identities = 49/151 (32%), Positives = 93/151 (61%), Gaps = 15/151 (9%)
Query: 476 PEEATRLLAEKR-RLAREQREKEERERREQEELERQK---REELAQRVAEERTTRREEES 531
P+ T L E+ R E RE+E++ R+++E++ RQ+ RE+ + +E RR+E+
Sbjct: 225 PQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKR 284
Query: 532 RRLEAEQAREKEEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERV-RQ----- 583
R + ++ RE+E++L+ E++ LRE+EE + Q +K E+E ++RE+ E++ RQ
Sbjct: 285 LREQEKELREQEKELR---EQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341
Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTE 614
E+EK + +EQ+ ++++R+ E +R R E
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKE 372
Score = 70.1 bits (170), Expect = 7e-12
Identities = 43/166 (25%), Positives = 101/166 (60%), Gaps = 21/166 (12%)
Query: 477 EEATRLLAEKRRLAREQ---REKEERERREQEEL-ERQKREELAQRVAEERTTRREEESR 532
+E R+ ++++ E+ RE+EE+ ++++E + E++++E QR+ E++ E+E
Sbjct: 389 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 448
Query: 533 RLEAEQAREKEEQLQRQAE----------ERALREREEA--ERAQRQKEEEARVREEAER 580
+ + E+ E+EE+++ Q E + +RE+E+ E+ ++ +++E ++ ++ ER
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 581 VRQEREKHFQREEQERLERKKRL---EEIMKRTRRTEATDKKTSDQ 623
+ ++ E+ RE++ER+ +K++ EE M+ ++T+ +KKT DQ
Sbjct: 509 MWEQDER--LREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQ 552
Score = 69.7 bits (169), Expect = 9e-12
Identities = 44/149 (29%), Positives = 95/149 (63%), Gaps = 13/149 (8%)
Query: 485 EKRRLAREQREKEERER-REQEEL---ERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
E+R +++R +E+ ER REQ+++ E + REE + E++T +EE+ R E + R
Sbjct: 506 EERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMRER 565
Query: 541 EK----EEQLQRQAEERALREREEAERAQRQK--EEEARVREEAERVRQEREKHFQREEQ 594
EK EE++ R+ EE+ ++E+EE R Q +K E+E +++E+ E++ ++ EK +++EE+
Sbjct: 566 EKKMREEEEMMREQEEK-MQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEE 624
Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQ 623
++++ ++ E + ++ + + ++K +Q
Sbjct: 625 DKMQEQE--EMMWEQEEKMQEQEEKMWEQ 651
Score = 69.7 bits (169), Expect = 9e-12
Identities = 40/133 (30%), Positives = 78/133 (58%), Gaps = 5/133 (3%)
Query: 478 EATRLLAEKRRLAREQR---EKEERERREQEELERQKRE-ELAQRVAEERTTRREEESRR 533
E L EK REQ+ ++EE+ R E++ E++K+ + +++ EE R E+ R
Sbjct: 511 EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMR 570
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERV-RQEREKHFQRE 592
E E RE+EE++Q Q E+ +E + E+ ++ +E+E ++ E+ E++ QE E Q +
Sbjct: 571 EEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQ 630
Query: 593 EQERLERKKRLEE 605
E+ E++++++E
Sbjct: 631 EEMMWEQEEKMQE 643
Score = 67.8 bits (164), Expect = 4e-11
Identities = 49/161 (30%), Positives = 92/161 (57%), Gaps = 20/161 (12%)
Query: 483 LAEKRRLAREQREK----EERERREQEELERQKRE--ELAQRVAEERTTRREEESRRLEA 536
L E+ +EQ EK EE+ R ++E++ RQ+ E +++ E+ R++E R E
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQ 364
Query: 537 -EQAREKEEQLQRQA-----EERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
E+ REKEE+++ Q EE+ E ER ++ +EEE +RE+ E+++++ E ++
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 591 REE----QERL-ERKKRL---EEIMKRTRRTEATDKKTSDQ 623
+EE Q+RL E+K++L E++ ++ + ++K DQ
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQ 465
Score = 67.8 bits (164), Expect = 4e-11
Identities = 45/151 (29%), Positives = 88/151 (58%), Gaps = 15/151 (9%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQE----ELERQKREELAQRVAEERTTRREEESR 532
E+ R+ +K+ +E++ +EE++ +EQE + E + REE R E++ R EEE
Sbjct: 518 EKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKM-REEEEMM 576
Query: 533 RLEAEQAREKEEQLQRQAE-----ERALREREEAERAQRQK----EEEARVREEAERVRQ 583
R + E+ +E+EE+++ Q E E ++E+EE Q +K EEE +++E+ E + +
Sbjct: 577 REQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWE 636
Query: 584 EREKHFQREEQERLERKKRLEEIMKRTRRTE 614
+ EK Q +E++ E+++++ E ++ R E
Sbjct: 637 QEEK-MQEQEEKMWEQEEKMREQEEKMREQE 666
Score = 65.9 bits (159), Expect = 1e-10
Identities = 45/140 (32%), Positives = 80/140 (57%), Gaps = 16/140 (11%)
Query: 478 EATRLLAEKRRLAREQREK---EERERREQEELERQKREELAQRVA-----EERTTRREE 529
E + + E+ + REQ EK +E + REQEE ++ E++ ++ EE+ +EE
Sbjct: 564 EREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEE 623
Query: 530 ESRRLEAEQAR-EKEEQLQRQAE-----ERALREREEAERAQRQK--EEEARVREEAERV 581
E + E E+ E+EE++Q Q E E +RE+EE R Q +K +E ++RE+ E++
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683
Query: 582 RQEREKHFQREEQERLERKK 601
+ + EK ++EE+ R + +K
Sbjct: 684 QGQEEKMREQEEKMRGQEEK 703
Score = 64.3 bits (155), Expect = 4e-10
Identities = 40/154 (25%), Positives = 86/154 (55%), Gaps = 11/154 (7%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAE-ERTTRREEESRRLE 535
++ R+ + RL REKEER R +++ E++++ + +R+ E E+ R EEE+ R +
Sbjct: 356 DQEERMWEQDERL----REKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411
Query: 536 AEQAREKEEQLQRQAE-----ERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQ 590
E+ +++EE + Q E +R ++E+ ++ +E+E ++ E+ E++R + E Q
Sbjct: 412 EEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ 471
Query: 591 REEQERLERKKRLEEIM-KRTRRTEATDKKTSDQ 623
++ R E+ + E+ M ++ + ++K DQ
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ 505
Score = 63.9 bits (154), Expect = 5e-10
Identities = 41/131 (31%), Positives = 82/131 (62%), Gaps = 10/131 (7%)
Query: 497 EERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEEQLQRQAEERALR 556
+E R++EEL Q+++ Q EE+ R+EE R E + RE+EE+++RQ E+ LR
Sbjct: 233 QEEMWRQEEELREQEKKIRKQ---EEKMWRQEERLREQEGKM-REQEEKMRRQ--EKRLR 286
Query: 557 EREEAERAQ-RQKEEEARVREEAERVRQEREKHFQREEQERLERKK---RLEEIMKRTRR 612
E+E+ R Q ++ E+ ++RE+ E+++++ EK +++EE+ R + +K + E + ++ ++
Sbjct: 287 EQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Query: 613 TEATDKKTSDQ 623
++K DQ
Sbjct: 347 MREQEQKMRDQ 357
Score = 63.5 bits (153), Expect = 7e-10
Identities = 36/143 (25%), Positives = 86/143 (60%), Gaps = 7/143 (4%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ ++ ++ ++ ++++ ++E R E+ ER + +E +R+ E++ ++EE R E
Sbjct: 483 EQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKE--ERMREQKKMWQQEEKMREEK 540
Query: 537 ---EQAREKEEQLQRQAEERALREREEAERAQRQ--KEEEARVREEAERVRQEREKHFQR 591
EQ ++ +Q ++ EE +RERE+ R + + +E+E +++E+ E++R++ EK +++
Sbjct: 541 KTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQ 600
Query: 592 EEQERLERKKRLEEIMKRTRRTE 614
EE+ + + +K E+ K + E
Sbjct: 601 EEKMQEQEEKMWEQEEKMWEQEE 623
Score = 63.2 bits (152), Expect = 9e-10
Identities = 44/202 (21%), Positives = 96/202 (47%), Gaps = 2/202 (0%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ ++ ++ ++ ++ + E+E + E+ E K +E + + E+ +E+E + E
Sbjct: 592 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQ 651
Query: 537 EQA-REKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHF-QREEQ 594
E+ RE+EE+++ Q E+ +E + E+ ++ + +E ++RE+ E++R + EK + Q E+
Sbjct: 652 EEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM 711
Query: 595 ERLERKKRLEEIMKRTRRTEATDKKTSDQRNGDIAKGALTGGTEVSALPCTTNAPGNGKP 654
E K +E M+ K+ +R + + S + C + G+ +P
Sbjct: 712 WGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPPSKVLCNMSHTGSVEP 771
Query: 655 VGSPHVVTSHQSKVTVESTPDL 676
G S Q T + L
Sbjct: 772 AGGEAGEGSPQDNPTAQEIMQL 793
Score = 62.8 bits (151), Expect = 1e-09
Identities = 35/133 (26%), Positives = 75/133 (56%), Gaps = 5/133 (3%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE---ESRRLEAEQARE 541
EK R +Q ++E + R+QE+ + E + ++ +ER +EE E +++ ++ +
Sbjct: 479 EKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQ--DERLREKEERMREQKKMWQQEEKM 536
Query: 542 KEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKK 601
+EE+ ++ E++ + E+ +R +E E ++REE E +R++ EK ++EE+ R + +K
Sbjct: 537 REEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEK 596
Query: 602 RLEEIMKRTRRTE 614
E+ K + E
Sbjct: 597 MWEQEEKMQEQEE 609
Score = 61.2 bits (147), Expect = 3e-09
Identities = 39/130 (30%), Positives = 78/130 (60%), Gaps = 7/130 (5%)
Query: 485 EKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAREKEE 544
EK+ +E+ ++E + EQEE R + +++ + EER ++E RL ++ R +E+
Sbjct: 472 EKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQ--EERMWEQDE---RLREKEERMREQ 526
Query: 545 QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLE 604
+ Q EE+ E++ E+ ++ ++E ++REE ER+R EREK + EE+ E++++++
Sbjct: 527 KKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE-ERMR-EREKKMREEEEMMREQEEKMQ 584
Query: 605 EIMKRTRRTE 614
E ++ R E
Sbjct: 585 EQEEKMREQE 594
Score = 58.9 bits (141), Expect = 2e-08
Identities = 45/147 (30%), Positives = 83/147 (56%), Gaps = 16/147 (10%)
Query: 483 LAEKRRLAREQREKEERERRE-QEELERQK--REELAQRVAEERTTRREEESRRLEAEQA 539
L EK RLA ++ + + +E + +LER K ++ +E R+EEE R E ++
Sbjct: 192 LQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEELREQE-KKI 250
Query: 540 REKEEQLQRQAE-----ERALREREEAERAQ--RQKEEEARVREEAERVRQ-----EREK 587
R++EE++ RQ E E +RE+EE R Q R +E+E +RE+ + +R+ E+E+
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEE 310
Query: 588 HFQREEQERLERKKRLEEIMKRTRRTE 614
Q +E++ E+++++ E ++ R E
Sbjct: 311 QMQEQEEKMWEQEEKMREQEEKMWRQE 337
Score = 58.9 bits (141), Expect = 2e-08
Identities = 41/144 (28%), Positives = 80/144 (55%), Gaps = 6/144 (4%)
Query: 481 RLLAEKRRLAREQREKEERERR-EQEELERQKREELAQRVAEERTTRREEESRRLEAEQA 539
RL +K +L +++ +E+ E+ EQEE R + E Q E+ R+E+ R E +Q
Sbjct: 434 RLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQ----EKKMWRQEKMREQE-DQM 488
Query: 540 REKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLER 599
E+EE+++ Q ++ +E E+ +R +E+E R+RE+ + +QE + +++ QE+ ++
Sbjct: 489 WEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKK 548
Query: 600 KKRLEEIMKRTRRTEATDKKTSDQ 623
EE M+ R +KK ++
Sbjct: 549 TWDQEEKMREEERMREREKKMREE 572
Score = 55.8 bits (133), Expect = 1e-07
Identities = 43/150 (28%), Positives = 76/150 (50%), Gaps = 14/150 (9%)
Query: 474 TDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRR 533
T +A L + + E+ +K+ E +E+ L ++ E+ V E + + E
Sbjct: 165 TKERDALSLELYRNTITNEELKKKNAELQEKLRLAESEKSEIQLNVKELKR-KLERAKFL 223
Query: 534 LEAEQAREKEEQLQRQAEERALREREEAERAQRQK---------EEEARVREEAERVRQE 584
L Q +E++ RQ EE LRE+E+ R Q +K E+E ++RE+ E++R++
Sbjct: 224 LPQVQTNTLQEEMWRQEEE--LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQ 281
Query: 585 REKHFQREEQERLERKKRLEEIMKRTRRTE 614
EK + +E+E E++K L E K+ R E
Sbjct: 282 -EKRLREQEKELREQEKELRE-QKKLREQE 309
Score = 55.1 bits (131), Expect = 2e-07
Identities = 41/141 (29%), Positives = 76/141 (53%), Gaps = 31/141 (21%)
Query: 475 DPEEATRLLAEKRRLAREQREKEERERR--EQEELERQKREELAQRVAEERTTRREEESR 532
+ EE ++ ++ + ++ + +E+E + EQEE R++ E++ R +EE
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM----------REQEEKM 669
Query: 533 RLEAEQAREKEEQLQRQAEERALREREEAERAQRQK----EE-----------EARVREE 577
+ + E+ RE+EE++Q Q E+ +RE+EE R Q +K EE + +RE+
Sbjct: 670 QGQEEKMREQEEKMQGQEEK--MREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREK 727
Query: 578 AERVRQEREKHFQR--EEQER 596
ER+R ++EK +R E +ER
Sbjct: 728 EERIRDQKEKMQERLPEHEER 748
Score = 47.4 bits (111), Expect = 5e-05
Identities = 29/88 (32%), Positives = 51/88 (57%), Gaps = 3/88 (3%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEKHLEERKK--RLEEQRQKEERRRAAVEEKRR 129
ER EREK++ E + E+EE+ ++ EK E+ +K EE+ Q++E + EEK
Sbjct: 560 ERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619
Query: 130 QRLEEDK-ERHEAVVRRTMERSQKPKQK 156
++ EEDK + E ++ E+ Q+ ++K
Sbjct: 620 EQEEEDKMQEQEEMMWEQEEKMQEQEEK 647
Score = 43.5 bits (101), Expect = 7e-04
Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 8/105 (7%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
D+R R ER E+EK E + E R R+ + EE + EE+ QK+E
Sbjct: 365 DERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWE 424
Query: 124 VEEK--RRQRLEEDK------ERHEAVVRRTMERSQKPKQKHNRW 160
EEK ++QRL E K E+ + + E+ +K + + W
Sbjct: 425 QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMW 469
Score = 42.7 bits (99), Expect = 0.001
Identities = 31/92 (33%), Positives = 50/92 (54%), Gaps = 9/92 (9%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQR---QKEERRRAAVEEKR 128
ER E+EKQ+ +E ++EER + E+ L E+++R+ EQ ++EE+ ++E+
Sbjct: 338 ERLWEQEKQMREQEQKMRDQEERMWEQDER-LREKEERMREQEKMWEQEEK----MQEEE 392
Query: 129 RQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
R R E K R E R E + KQ+ N W
Sbjct: 393 RIREREKKMREEEETMREQEEKMQ-KQEENMW 423
Score = 42.7 bits (99), Expect = 0.001
Identities = 24/90 (26%), Positives = 48/90 (53%), Gaps = 5/90 (5%)
Query: 72 ERREEREKQLAAREIVWLE----REERARQHYEKHL-EERKKRLEEQRQKEERRRAAVEE 126
ER E+E+++ ++ +W + REE+ Q EK ++ +K EE+R +E ++ EE
Sbjct: 514 ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEE 573
Query: 127 KRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ + EE + E +R E+ + ++K
Sbjct: 574 EMMREQEEKMQEQEEKMREQEEKMWEQEEK 603
Score = 42.7 bits (99), Expect = 0.001
Identities = 25/91 (27%), Positives = 49/91 (53%), Gaps = 6/91 (6%)
Query: 74 REEREKQLAAREIVWLEREERARQHYEKHLE-ERKKRLEEQRQKEERRRAAVEEKRRQRL 132
+EE +K E++W E+EE+ ++ EK E E K R +E++ +E+ + +E++ +
Sbjct: 621 QEEEDKMQEQEEMMW-EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQ 679
Query: 133 EEDKERHEAVVRRTMERSQKPKQKHNRWSWG 163
EE + E +R E+ + ++K WG
Sbjct: 680 EEKMQGQEEKMREQEEKMRGQEEK----MWG 706
Score = 41.2 bits (95), Expect = 0.004
Identities = 22/99 (22%), Positives = 49/99 (49%), Gaps = 3/99 (3%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
++ R E RE+ +K E +W + E Q + +E K R +E+R +E+ +
Sbjct: 234 EEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELR 293
Query: 124 VEEK---RRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+EK +++L E +E+ + + E+ +K +++ +
Sbjct: 294 EQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEK 332
Score = 40.8 bits (94), Expect = 0.005
Identities = 26/93 (27%), Positives = 49/93 (52%), Gaps = 2/93 (2%)
Query: 68 RLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEK 127
R E+ +E++L +E E+EE+ R+ EK L E++K L EQ +KE R + + E+
Sbjct: 251 RKQEEKMWRQEERLREQEGKMREQEEKMRRQ-EKRLREQEKELREQ-EKELREQKKLREQ 308
Query: 128 RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
Q E++++ E + + + +Q+ W
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341
Score = 40.8 bits (94), Expect = 0.005
Identities = 23/96 (23%), Positives = 51/96 (53%), Gaps = 3/96 (3%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKK---RLEEQRQKEERR 120
++ R E+ +E+E+++ +E E+EE+ ++ EK E+ +K + EE + +E+
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEE 632
Query: 121 RAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E++ Q EE E +R E+ ++ ++K
Sbjct: 633 MMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEK 668
Score = 40.0 bits (92), Expect = 0.008
Identities = 25/97 (25%), Positives = 47/97 (48%), Gaps = 12/97 (12%)
Query: 74 REEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVE-------- 125
R++ +K E +W E++ER R+ E+ E++K +E++ +EE++ E
Sbjct: 496 RDQEQKMWDQEERMW-EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEE 554
Query: 126 ---EKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
E+ R R E K R E + R E + +++ R
Sbjct: 555 KMREEERMREREKKMREEEEMMREQEEKMQEQEEKMR 591
Score = 39.7 bits (91), Expect = 0.010
Identities = 37/145 (25%), Positives = 75/145 (51%), Gaps = 10/145 (6%)
Query: 470 SAGTTDPEEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
SA +T ++A R + E + + R EEL++ K EL +++ + + E
Sbjct: 148 SAVSTWHKKADRYIEELTKERDALSLELYRNTITNEELKK-KNAELQEKLRLAESEKSEI 206
Query: 530 ESRRLEAEQAREKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHF 589
+ E ++ E+ + L Q + L+E RQ+EE +RE+ +++R++ EK +
Sbjct: 207 QLNVKELKRKLERAKFLLPQVQTNTLQEE-----MWRQEEE---LREQEKKIRKQEEKMW 258
Query: 590 QREEQERLERKKRLEEIMKRTRRTE 614
++EE+ R E++ ++ E ++ RR E
Sbjct: 259 RQEERLR-EQEGKMREQEEKMRRQE 282
Score = 39.7 bits (91), Expect = 0.010
Identities = 26/98 (26%), Positives = 54/98 (55%), Gaps = 3/98 (3%)
Query: 60 VLRVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQR--QKE 117
+ + +++ ER E+E ++ +E +E+R R+ EK L E++K L EQ+ +++
Sbjct: 250 IRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQ-EKELREQEKELREQKKLREQ 308
Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQ 155
E + EEK ++ E+ +E+ E + R+ ++ KQ
Sbjct: 309 EEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQ 346
Score = 39.7 bits (91), Expect = 0.010
Identities = 28/102 (27%), Positives = 55/102 (53%), Gaps = 4/102 (3%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKR-LEEQRQKEERR 120
R ++R R + E+E+++ +E E+E+ R+ ++ E++K R EEQ Q++E +
Sbjct: 259 RQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK 318
Query: 121 RAAVEEKRRQRLEE---DKERHEAVVRRTMERSQKPKQKHNR 159
EEK R++ E+ +ER ++ E+ QK + + R
Sbjct: 319 MWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEER 360
Score = 39.7 bits (91), Expect = 0.010
Identities = 24/100 (24%), Positives = 49/100 (49%), Gaps = 6/100 (6%)
Query: 67 QRLARERREEREKQLAAREIVWLEREERARQHYEKHL--EERKKRLEEQRQKEERRRAAV 124
+RL + +E RE++ RE L +E Q E+ + +E K R +E++ + R
Sbjct: 283 KRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWE 342
Query: 125 EEK----RRQRLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
+EK + Q++ + +ER R E+ ++ +++ W
Sbjct: 343 QEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMW 382
Score = 39.7 bits (91), Expect = 0.010
Identities = 26/98 (26%), Positives = 45/98 (45%), Gaps = 5/98 (5%)
Query: 64 DDRQRLARERREEREKQLAAREIV-----WLEREERARQHYEKHLEERKKRLEEQRQKEE 118
D+R R ER E++K E + E+E++ EK EE + R E++ +EE
Sbjct: 513 DERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E++ Q EE E + E+ Q+ ++K
Sbjct: 573 EEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEK 610
Score = 38.9 bits (89), Expect = 0.018
Identities = 24/99 (24%), Positives = 54/99 (54%), Gaps = 7/99 (7%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERAR------QHYEKHLEERKKRLEEQRQKE 117
+++ R ++ ++E+++ ++ E+EER R Q EK EE+K + +E++ +
Sbjct: 492 EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWD 551
Query: 118 ERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+ + EE+ R+R E+ E ++R E+ Q+ ++K
Sbjct: 552 QEEKMREEERMRER-EKKMREEEEMMREQEEKMQEQEEK 589
Score = 38.9 bits (89), Expect = 0.018
Identities = 21/101 (20%), Positives = 54/101 (53%), Gaps = 3/101 (2%)
Query: 62 RVDDRQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEE 118
R+ +R++ RE E E+E+++ +E E+EE+ + EK E+ +K E++ + E
Sbjct: 561 RMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWE 620
Query: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ +++ + + E +E+ + + E+ +K +++ +
Sbjct: 621 QEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEK 661
Score = 38.5 bits (88), Expect = 0.023
Identities = 27/97 (27%), Positives = 53/97 (54%), Gaps = 7/97 (7%)
Query: 66 RQRLARERRE---EREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
RQ RE+ + E+E+++ +E ++EER + E+ L E+++R+ EQ++ ++
Sbjct: 477 RQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDER-LREKEERMREQKKMWQQEEK 535
Query: 123 AVEEKRRQRLEE---DKERHEAVVRRTMERSQKPKQK 156
EEK+ Q E+ D+E R ER +K +++
Sbjct: 536 MREEKKTQEQEKKTWDQEEKMREEERMREREKKMREE 572
Score = 38.5 bits (88), Expect = 0.023
Identities = 22/79 (27%), Positives = 45/79 (56%), Gaps = 2/79 (2%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRR 121
+D+ + E E+E+++ +E E+EE+ R+ EK EE+ + EE+ +++E +
Sbjct: 624 EDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKM 683
Query: 122 AAVEEKRRQRLEEDKERHE 140
EEK R++ E+ + + E
Sbjct: 684 QGQEEKMREQEEKMRGQEE 702
Score = 38.5 bits (88), Expect = 0.023
Identities = 27/84 (32%), Positives = 45/84 (53%), Gaps = 10/84 (11%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHL---------EERKKRLEEQR 114
+++ + E+ E+E+++ +E E+EE+ R EK EE+ EE R
Sbjct: 666 EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMR 725
Query: 115 QKEERRRAAVEEKRRQRLEEDKER 138
+KEER R +EK ++RL E +ER
Sbjct: 726 EKEERIRDQ-KEKMQERLPEHEER 748
Score = 38.1 bits (87), Expect = 0.030
Identities = 25/116 (21%), Positives = 60/116 (51%), Gaps = 9/116 (7%)
Query: 55 PDPPPVLRVDDRQRLARERREEREKQLAAREIVW-----LEREERARQHYEKHLEERKKR 109
P+ L ++ + E+ E+E+++ +E +W + R+E+ R+ E + E++++
Sbjct: 436 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQ-EDQMWEQEEK 494
Query: 110 LEEQRQK---EERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNRWSW 162
+ +Q QK +E R +E+ R++ E +E+ + + R +K Q+ + +W
Sbjct: 495 MRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTW 550
Score = 37.0 bits (84), Expect = 0.067
Identities = 19/93 (20%), Positives = 45/93 (48%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAA 123
+ ++ +E + EK+ +E ++EE+ R+ E+K R EE+ +E+ +
Sbjct: 525 EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 584
Query: 124 VEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
+E++ + EE E ++ E+ + ++K
Sbjct: 585 EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEK 617
Score = 36.6 bits (83), Expect = 0.088
Identities = 28/99 (28%), Positives = 49/99 (49%), Gaps = 14/99 (14%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEK--HLEERKKRLEEQRQKEERRRAAVEEKRR 129
E+ +E+E+++ +E E+EE+ R+ EK EE+ + EE+ Q +E + EEK R
Sbjct: 639 EKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698
Query: 130 QRLE------------EDKERHEAVVRRTMERSQKPKQK 156
+ E E+K + +R ER + K+K
Sbjct: 699 GQEEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEK 737
Score = 36.2 bits (82), Expect = 0.11
Identities = 24/95 (25%), Positives = 50/95 (52%), Gaps = 2/95 (2%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLE-ERKKRLEEQRQKEERRRA 122
+++ R E+ E+E+++ +E E+EE+ + EK E E K R +E++ + +
Sbjct: 652 EEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKM 711
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKH 157
+E++ EE +E+ E +R E+ Q+ +H
Sbjct: 712 WGQEEKMWGQEEMREKEER-IRDQKEKMQERLPEH 745
Score = 35.8 bits (81), Expect = 0.15
Identities = 26/105 (24%), Positives = 50/105 (47%), Gaps = 20/105 (19%)
Query: 72 ERREEREKQL-------AAREIVWLEREERARQ------------HYEKHLEERKKRLEE 112
+R+ ER K L +E +W + EE Q E+ L E++ ++ E
Sbjct: 214 KRKLERAKFLLPQVQTNTLQEEMWRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE 273
Query: 113 QRQKEERRRAAVEEKRRQRLEEDKE-RHEAVVRRTMERSQKPKQK 156
Q +K R+ + E+ ++ E++KE R + +R E+ Q+ ++K
Sbjct: 274 QEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEK 318
Score = 34.3 bits (77), Expect = 0.43
Identities = 18/97 (18%), Positives = 49/97 (50%), Gaps = 2/97 (2%)
Query: 64 DDRQRLARERR-EEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRA 122
+++ R E+ E+ EK E +W + E+ Q E ++E+++ + EQ +K + +
Sbjct: 587 EEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEE 646
Query: 123 AVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+ E+ +++ E +E+ + + +K +++ +
Sbjct: 647 KMWEQE-EKMREQEEKMREQEEKMQGQEEKMREQEEK 682
Score = 32.7 bits (73), Expect = 1.3
Identities = 22/90 (24%), Positives = 45/90 (50%), Gaps = 6/90 (6%)
Query: 71 RERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAVEEKRRQ 130
+E + E+++ RE E EE R+ EE+ + EE+ +++E + EEK ++
Sbjct: 552 QEEKMREEERMREREKKMREEEEMMREQ-----EEKMQEQEEKMREQEEKMWEQEEKMQE 606
Query: 131 RLEEDKERHEAVVRRTMERSQKPKQKHNRW 160
+ E+ E+ E + + E + +Q+ W
Sbjct: 607 QEEKMWEQEEKMWEQE-EEDKMQEQEEMMW 635
>gi|239745299 PREDICTED: hypothetical protein [Homo sapiens]
Length = 523
Score = 75.9 bits (185), Expect = 1e-13
Identities = 58/177 (32%), Positives = 87/177 (49%), Gaps = 7/177 (3%)
Query: 444 APAPVPTPAMVSAPSSTVNASASVKTSAGT---TDPEEATRLLAEKRRLAREQREKEERE 500
AP P P+ V N S G + E L RR RE+EER
Sbjct: 149 APEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQEERL 208
Query: 501 RREQEELERQKRE--ELAQRVAEERTTRREEESRRLEAEQ-AREKEEQLQRQAEERALRE 557
R ++E L Q+ E +R+ E+ RE+E R E E+ RE EE+L Q E +E
Sbjct: 209 REQEERLREQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQE 268
Query: 558 REEAERAQRQKEEEARVREEAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTE 614
E+ +R E+E R+ E+ ER+R++ E+ ++EE+ R E+++RL E +R R E
Sbjct: 269 ERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLR-EQEERLCEQEERLREQE 324
Score = 72.4 bits (176), Expect = 1e-12
Identities = 49/164 (29%), Positives = 90/164 (54%), Gaps = 18/164 (10%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEA 536
E+ RL ++ RL ++ E+E R +E+ ER + +E +R+ E+ RE E R E
Sbjct: 203 EQEERLREQEERLREQEERLCEQEERLREQEERLREQE--ERLCEQEERLREHEERLCEQ 260
Query: 537 EQAR-EKEEQLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREKHFQRE--- 592
E+ E+EE+L+ Q E +E E+ +R +E+E R+ E+ ER+R++ E+ ++E
Sbjct: 261 EERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEERLCEQEERL 320
Query: 593 --------EQERLERKKRL----EEIMKRTRRTEATDKKTSDQR 624
EQE+L ++RL E+++++ RR E ++ +R
Sbjct: 321 REQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERER 364
Score = 70.5 bits (171), Expect = 5e-12
Identities = 54/172 (31%), Positives = 87/172 (50%), Gaps = 24/172 (13%)
Query: 477 EEATRLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLE- 535
E RL ++ RL ++ E+E R E+ ER +E R EER +EE R E
Sbjct: 252 EHEERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEERLCEQEERLREQEE 311
Query: 536 -----AEQAREKEEQLQRQ----AEERALREREEAERAQRQKEEEARVRE---------- 576
E+ RE+EE+L Q +ER L E E+ +R++EE+ R+ E
Sbjct: 312 RLCEQEERLREQEERLCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERERLLEEVEE 371
Query: 577 --EAERVRQEREKHFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNG 626
E ER+RQ+ E+ +Q+E + LER + LE +++ EA ++ ++ R+G
Sbjct: 372 LLEQERLRQQDERLWQQETLQELERLRELERMLE--LGWEALYEQRAEPRSG 421
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/155 (36%), Positives = 84/155 (54%), Gaps = 27/155 (17%)
Query: 477 EEATRLLAEKRRLAREQREKEERERR--EQEELERQKREELAQ---RVAEERTTRREEES 531
E+ RL ++ RL ++ E+E R EQEE R+ E L + R+ E+ RE+E
Sbjct: 217 EQEERLCEQEERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEE 276
Query: 532 RRLEAEQA--------REKEEQLQRQAEERALREREE--AERAQRQKEEEARVREEAERV 581
R E E+ RE+EE+L Q E LRE+EE E+ +R +E+E R+ E+ +
Sbjct: 277 RLHEQEERLCEQEERLREQEERLCEQ--EERLREQEERLCEQEERLREQEERLCEQEKLP 334
Query: 582 RQER---------EKHFQREEQER-LERKKRLEEI 606
QER E+ ++EEQER LER++ LEE+
Sbjct: 335 GQERLLEEVEKLLEQERRQEEQERLLERERLLEEV 369
Score = 50.1 bits (118), Expect = 8e-06
Identities = 33/104 (31%), Positives = 58/104 (55%), Gaps = 7/104 (6%)
Query: 62 RVDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL--EEQRQKEER 119
R ++R R ER E+E++L +E E+EER R+ E+ L E+++RL +E+R +E
Sbjct: 196 RQEERLREQEERLREQEERLREQEERLCEQEERLREQ-EERLREQEERLCEQEERLREHE 254
Query: 120 RRAAVEEKR----RQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R +E+R +RL E +ER R E+ ++ +++ R
Sbjct: 255 ERLCEQEERLCEQEERLREQEERLHEQEERLCEQEERLREQEER 298
Score = 44.3 bits (103), Expect = 4e-04
Identities = 28/89 (31%), Positives = 50/89 (56%), Gaps = 4/89 (4%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLE-EQRQKEERRRAAVEEKRRQ 130
ER E+E++L +E E+EER R+H E+ E+ ++ E E+R +E+ R +E +
Sbjct: 227 ERLREQEERLREQEERLCEQEERLREHEERLCEQEERLCEQEERLREQEERLHEQE---E 283
Query: 131 RLEEDKERHEAVVRRTMERSQKPKQKHNR 159
RL E +ER R E+ ++ +++ R
Sbjct: 284 RLCEQEERLREQEERLCEQEERLREQEER 312
Score = 41.2 bits (95), Expect = 0.004
Identities = 31/100 (31%), Positives = 54/100 (54%), Gaps = 10/100 (10%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK----EER 119
++R R ER E+E++L E E+EER + E+ L E+++RL EQ ++ EER
Sbjct: 233 EERLREQEERLCEQEERLREHEERLCEQEERLCEQ-EERLREQEERLHEQEERLCEQEER 291
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
R ++ +RL E +ER R E+ ++ +++ R
Sbjct: 292 LR-----EQEERLCEQEERLREQEERLCEQEERLREQEER 326
Score = 41.2 bits (95), Expect = 0.004
Identities = 31/98 (31%), Positives = 55/98 (56%), Gaps = 11/98 (11%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRL--EEQRQKEERRR 121
++R R ER E+E++L +E E+EER + E+ L E+++RL +E+R +E+ R
Sbjct: 268 EERLREQEERLHEQEERLCEQEERLREQEERLCEQ-EERLREQEERLCEQEERLREQEER 326
Query: 122 AAVEEK---RRQRLEE-----DKERHEAVVRRTMERSQ 151
+EK + + LEE ++ER + R +ER +
Sbjct: 327 LCEQEKLPGQERLLEEVEKLLEQERRQEEQERLLERER 364
Score = 41.2 bits (95), Expect = 0.004
Identities = 34/125 (27%), Positives = 56/125 (44%), Gaps = 23/125 (18%)
Query: 481 RLLAEKRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRLEAEQAR 540
RLL E +L ++R +EE+ER + E ++ EEL LE E+ R
Sbjct: 338 RLLEEVEKLLEQERRQEEQERLLERERLLEEVEEL------------------LEQERLR 379
Query: 541 EKEEQLQRQAEERALREREEAERA-----QRQKEEEARVREEAERVRQEREKHFQREEQE 595
+++E+L +Q + L E ER + E+ A R E + E + Q E+Q
Sbjct: 380 QQDERLWQQETLQELERLRELERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQV 439
Query: 596 RLERK 600
+ +K
Sbjct: 440 KELKK 444
Score = 40.4 bits (93), Expect = 0.006
Identities = 32/97 (32%), Positives = 53/97 (54%), Gaps = 10/97 (10%)
Query: 64 DDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK----EER 119
++R R ER E+E++L +E E+EER + E+ L E+++RL EQ ++ EER
Sbjct: 247 EERLREHEERLCEQEERLCEQEERLREQEERLHEQ-EERLCEQEERLREQEERLCEQEER 305
Query: 120 RRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQK 156
R ++ +RL E +ER R E+ + P Q+
Sbjct: 306 LR-----EQEERLCEQEERLREQEERLCEQEKLPGQE 337
Score = 38.9 bits (89), Expect = 0.018
Identities = 28/98 (28%), Positives = 53/98 (54%), Gaps = 5/98 (5%)
Query: 63 VDDRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKK-RLEEQRQKEERRR 121
V++ Q L+ R + E+ L +E E+EER R+ E+ E+ ++ R +E+R +E+ R
Sbjct: 184 VENNQMLSLLNRRQEER-LREQEERLREQEERLREQEERLCEQEERLREQEERLREQEER 242
Query: 122 AAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
+E +RL E +ER R E+ ++ +++ R
Sbjct: 243 LCEQE---ERLREHEERLCEQEERLCEQEERLREQEER 277
Score = 38.9 bits (89), Expect = 0.018
Identities = 28/89 (31%), Positives = 49/89 (55%), Gaps = 5/89 (5%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQK----EERRRAAVEEK 127
ER E+E++L +E E+EER R+ E+ L E+++RL EQ ++ EER R E
Sbjct: 269 ERLREQEERLHEQEERLCEQEERLREQ-EERLCEQEERLREQEERLCEQEERLREQEERL 327
Query: 128 RRQRLEEDKERHEAVVRRTMERSQKPKQK 156
Q +ER V + +E+ ++ +++
Sbjct: 328 CEQEKLPGQERLLEEVEKLLEQERRQEEQ 356
Score = 37.0 bits (84), Expect = 0.067
Identities = 29/98 (29%), Positives = 51/98 (52%), Gaps = 10/98 (10%)
Query: 72 ERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRR------AAVE 125
ER E+E++L +E E+EER + E+ L E+++RL EQ + + R +E
Sbjct: 290 ERLREQEERLCEQEERLREQEERLCEQ-EERLREQEERLCEQEKLPGQERLLEEVEKLLE 348
Query: 126 EKRRQRLEE---DKERHEAVVRRTMERSQKPKQKHNRW 160
++RRQ +E ++ER V +E+ + +Q W
Sbjct: 349 QERRQEEQERLLERERLLEEVEELLEQERLRQQDERLW 386
Score = 34.7 bits (78), Expect = 0.33
Identities = 38/122 (31%), Positives = 52/122 (42%), Gaps = 17/122 (13%)
Query: 477 EEATRLLAEKRR-------LAREQREKEERERREQEELERQKREELAQRVAEERTTRREE 529
EE +LL ++RR L RE+ +E E EQE L RQ+ E L Q+ + R E
Sbjct: 341 EEVEKLLEQERRQEEQERLLERERLLEEVEELLEQERL-RQQDERLWQQETLQELERLRE 399
Query: 530 ESRRLEA------EQAREKE---EQLQRQAEERALREREEAERAQRQKEEEARVREEAER 580
R LE EQ E E+L + + E++ E + EE R E A
Sbjct: 400 LERMLELGWEALYEQRAEPRSGFEELNNENKSTLQLEQQVKELKKSGGAEEPRGSESAAA 459
Query: 581 VR 582
R
Sbjct: 460 AR 461
Score = 34.3 bits (77), Expect = 0.43
Identities = 30/116 (25%), Positives = 54/116 (46%), Gaps = 20/116 (17%)
Query: 55 PDPPP----VLRVDDRQRLARERREEREKQLAAR-------EIVWLEREERARQHYEKHL 103
P+PP V ++ D R+ E +QL A ++ +EER R+
Sbjct: 150 PEPPAGPSKVEQLQDETNHLRKELESVGRQLQAEVENNQMLSLLNRRQEERLREQ----- 204
Query: 104 EERKKRLEEQRQKEERRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQKPKQKHNR 159
EER + EE+ +++E R EE+ R++ E +E+ E R E+ ++ ++ R
Sbjct: 205 EERLREQEERLREQEERLCEQEERLREQEERLREQEE----RLCEQEERLREHEER 256
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.124 0.341
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,540,581
Number of Sequences: 37866
Number of extensions: 2066862
Number of successful extensions: 98782
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1549
Number of HSP's successfully gapped in prelim test: 2416
Number of HSP's that attempted gapping in prelim test: 20086
Number of HSP's gapped (non-prelim): 34727
length of query: 749
length of database: 18,247,518
effective HSP length: 110
effective length of query: 639
effective length of database: 14,082,258
effective search space: 8998562862
effective search space used: 8998562862
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.