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Search of human proteins with 4504993
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504993 leukemia inhibitory factor receptor precursor [Homo
sapiens]
(1097 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504993 leukemia inhibitory factor receptor precursor [Homo s... 2254 0.0
gi|189083786 leukemia inhibitory factor receptor precursor [Homo... 2254 0.0
gi|4557040 oncostatin M receptor [Homo sapiens] 411 e-114
gi|28610147 interleukin 6 signal transducer isoform 1 precursor ... 187 5e-47
gi|115430248 gp130-like monocyte receptor [Homo sapiens] 135 2e-31
gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens] 126 1e-28
gi|27437045 colony stimulating factor 3 receptor isoform d precu... 102 3e-21
gi|24496783 colony stimulating factor 3 receptor isoform c precu... 102 3e-21
gi|4503081 colony stimulating factor 3 receptor isoform a precur... 102 3e-21
gi|27437042 colony stimulating factor 3 receptor isoform b precu... 96 1e-19
gi|28610149 interleukin 6 signal transducer isoform 2 precursor ... 84 1e-15
gi|51093381 leptin receptor isoform 3 [Homo sapiens] 74 6e-13
gi|51093379 leptin receptor isoform 2 [Homo sapiens] 74 6e-13
gi|40254464 leptin receptor isoform 1 [Homo sapiens] 74 6e-13
gi|4506309 protein tyrosine phosphatase, receptor type, D isofor... 68 5e-11
gi|18860890 protein tyrosine phosphatase, receptor type, D isofo... 68 5e-11
gi|18860892 protein tyrosine phosphatase, receptor type, D isofo... 67 7e-11
gi|81158224 neuronal cell adhesion molecule isoform B precursor ... 65 4e-10
gi|148806908 fibronectin type III domain containing 1 [Homo sapi... 64 1e-09
gi|27894376 cell adhesion molecule with homology to L1CAM precur... 64 1e-09
gi|4758062 cytokine receptor-like factor 1 [Homo sapiens] 64 1e-09
gi|81158226 neuronal cell adhesion molecule isoform A precursor ... 63 1e-09
gi|109633041 protein tyrosine phosphatase, receptor type, F isof... 63 2e-09
gi|109633039 protein tyrosine phosphatase, receptor type, F isof... 63 2e-09
gi|24430212 interleukin 23 receptor precursor [Homo sapiens] 62 2e-09
gi|104487002 protein tyrosine phosphatase, receptor type, D isof... 59 3e-08
gi|18860894 protein tyrosine phosphatase, receptor type, D isofo... 59 3e-08
gi|75709184 contactin 3 [Homo sapiens] 58 4e-08
gi|222537743 protein tyrosine phosphatase, receptor type, Q [Hom... 58 6e-08
gi|104487006 protein tyrosine phosphatase, receptor type, sigma ... 55 3e-07
>gi|4504993 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 2254 bits (5840), Expect = 0.0
Identities = 1097/1097 (100%), Positives = 1097/1097 (100%)
Query: 1 MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL 60
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL
Sbjct: 1 MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL 60
Query: 61 QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS 120
QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS
Sbjct: 61 QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS 120
Query: 121 STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE 180
STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
Sbjct: 121 STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE 180
Query: 181 SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP 240
SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP
Sbjct: 181 SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP 240
Query: 241 VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK 300
VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK
Sbjct: 241 VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK 300
Query: 301 IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
Sbjct: 301 IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
Query: 361 LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ 420
LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ
Sbjct: 361 LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ 420
Query: 421 STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR 480
STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR
Sbjct: 421 STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR 480
Query: 481 NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD 540
NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
Sbjct: 481 NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD 540
Query: 541 TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK 600
TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK
Sbjct: 541 TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK 600
Query: 601 NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK 660
NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK
Sbjct: 601 NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK 660
Query: 661 WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE 720
WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE
Sbjct: 661 WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE 720
Query: 721 ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR 780
ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR
Sbjct: 721 ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR 780
Query: 781 SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840
SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI
Sbjct: 781 SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840
Query: 841 LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM 900
LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM
Sbjct: 841 LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM 900
Query: 901 NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN 960
NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN
Sbjct: 901 NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN 960
Query: 961 PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE 1020
PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE
Sbjct: 961 PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE 1020
Query: 1021 DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS 1080
DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS
Sbjct: 1021 DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS 1080
Query: 1081 NGGGWSFTNFFQNKPND 1097
NGGGWSFTNFFQNKPND
Sbjct: 1081 NGGGWSFTNFFQNKPND 1097
>gi|189083786 leukemia inhibitory factor receptor precursor [Homo
sapiens]
Length = 1097
Score = 2254 bits (5840), Expect = 0.0
Identities = 1097/1097 (100%), Positives = 1097/1097 (100%)
Query: 1 MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL 60
MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL
Sbjct: 1 MMDIYVCLKRPSWMVDNKRMRTASNFQWLLSTFILLYLMNQVNSQKKGAPHDLKCVTNNL 60
Query: 61 QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS 120
QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS
Sbjct: 61 QVWNCSWKAPSGTGRGTDYEVCIENRSRSCYQLEKTSIKIPALSHGDYEITINSLHDFGS 120
Query: 121 STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE 180
STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE
Sbjct: 121 STSKFTLNEQNVSLIPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKE 180
Query: 181 SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP 240
SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP
Sbjct: 181 SMELVKLVTHNTTLNGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSP 240
Query: 241 VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK 300
VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK
Sbjct: 241 VKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIK 300
Query: 301 IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA
Sbjct: 301 IRNISVSASSGTNVVFTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
Query: 361 LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ 420
LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ
Sbjct: 361 LVGPRATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQ 420
Query: 421 STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR 480
STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR
Sbjct: 421 STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQR 480
Query: 481 NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD 540
NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD
Sbjct: 481 NVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD 540
Query: 541 TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK 600
TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK
Sbjct: 541 TWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDK 600
Query: 601 NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK 660
NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK
Sbjct: 601 NDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYDPNMTCDYVIK 660
Query: 661 WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE 720
WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE
Sbjct: 661 WCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIE 720
Query: 721 ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR 780
ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR
Sbjct: 721 ELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGR 780
Query: 781 SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840
SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI
Sbjct: 781 SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840
Query: 841 LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM 900
LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM
Sbjct: 841 LIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQKSVCEGSSALKTLEM 900
Query: 901 NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN 960
NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN
Sbjct: 901 NPCTPNNVEVLETRSAFPKIEDTEIISPVAERPEDRSDAEPENHVVVSYCPPIIEEEIPN 960
Query: 961 PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE 1020
PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE
Sbjct: 961 PAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINSTVEDIAAEE 1020
Query: 1021 DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS 1080
DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS
Sbjct: 1021 DLDKTAGYRPQANVNTWNLVSPDSPRSIDSNSEIVSFGSPCSINSRQFLIPPKDEDSPKS 1080
Query: 1081 NGGGWSFTNFFQNKPND 1097
NGGGWSFTNFFQNKPND
Sbjct: 1081 NGGGWSFTNFFQNKPND 1097
>gi|4557040 oncostatin M receptor [Homo sapiens]
Length = 979
Score = 411 bits (1056), Expect = e-114
Identities = 264/806 (32%), Positives = 421/806 (52%), Gaps = 54/806 (6%)
Query: 135 IPDTPEILNLSADFSTSTLYLKWNDRGSVFPHRSNVIWEIKVLRKESMELVKLVTHNTTL 194
+P TP L +S + + +L+L+W + ++++I++ R E+ ++ + ++TT+
Sbjct: 30 LPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTV 89
Query: 195 NGKDTLHHWSWASDMPLECAIHFVEIRCYIDNLHFSGLEEWSDWSPVKNISWIPDSQTK- 253
LH WSW S++PLECA HFV I+ +D+ F WS+WS + +S + DS +
Sbjct: 90 KWNQVLH-WSWESELPLECATHFVRIKSLVDDAKFPEPNFWSNWSSWEEVS-VQDSTGQD 147
Query: 254 ---VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPL----IH---LDGENVAIKIRN 303
VFP+DK++ G+++T C VS+ + + +C L IH LD A + +
Sbjct: 148 ILFVFPKDKLVEEGTNVTICYVSRN-----IQNNVSCYLEGKQIHGEQLDPHVTAFNLNS 202
Query: 304 ISVSASSGTNVVF-----TTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRV 358
+ + GTN+ + + G V+F + P+ +CET D K + C+W+PG
Sbjct: 203 VPFIRNKGTNIYCEASQGNVSEGMKGIVLFVSKVLEEPKDFSCETEDFKTLHCTWDPGTD 262
Query: 359 TALVGPR--ATSYTLVESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPL 416
TAL + + SYTL ESFSG+ + T++++ +QE YNFTL A N L
Sbjct: 263 TALGWSKQPSQSYTLFESFSGE------KKLCTHKNWCNWQITQDSQETYNFTLIAENYL 316
Query: 417 GRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSV 476
+ IL N+T +VY P S +++N+T ++W + +LC+IE+ +
Sbjct: 317 RKRSVNILFNLTHRVYLMNPFSVNFENVNATNAIMTWKVHSIRNNFTYLCQIELHGEGKM 376
Query: 477 QEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQHLTTEASP 535
Q NV+IK N Y L +L P T Y R+RC+ + FWKWS+WS + T EA+P
Sbjct: 377 M-QYNVSIK--VNGEYF--LSELEPATEYMARVRCADASHFWKWSEWSGQN-FTTLEAAP 430
Query: 536 SKGPDTWREWSSDGKN--LIIYWKPLPINEANGKILSYNVSCSSDEETQS--LSEIPDPQ 591
S+ PD WR S + N + ++WKPL ANGKIL YNV + ++ S L IP P
Sbjct: 431 SEAPDVWRIVSLEPGNHTVTLFWKPLSKLHANGKILFYNVVVENLDKPSSSELHSIPAPA 490
Query: 592 HKAEIRLDKNDYIISVVAKNSVGSSPPSKIA-SMEIPNDDLKIEQVVGMGKGILLTWHYD 650
+ ++ LD+ Y I V+A NSVG+SP S I S + N +++ E++ G G L+W
Sbjct: 491 NSTKLILDRCSYQICVIANNSVGASPASVIVISADPENKEVEEERIAGTEGGFSLSWKPQ 550
Query: 651 PNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQ 710
P YV+ WC+ ++ W+ V N+T TVI +D FRPG+RY+F +YG +
Sbjct: 551 PGDVIGYVVDWCDHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIYGLSTKRIA 610
Query: 711 -LLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERD 769
LL GY +ELAP P+ V+ ++ S + W+D E GF++GY Y R
Sbjct: 611 CLLEKKTGYSQELAPSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQ 670
Query: 770 TS---KMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSM- 825
+ VL G K K I + +K L + +L+ ++ Y + +T G GP +
Sbjct: 671 CHPRFEKAVLSDGSECCKYK-IDNPEEKALIVDNLKPESFYEFFITPFTSAGEGPSATFT 729
Query: 826 YVVTKENSVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNPENCKALQFQ 885
V T + ++I IL+P+ V+ + ++CY K +WIKET YPDIP+P L
Sbjct: 730 KVTTPDEHSSMLIHILLPMVFCVL---LIMVMCYLKSQWIKETCYPDIPDPYKSSILSLI 786
Query: 886 KSVCEGSSALKTLEMNPCTPNNVEVL 911
K + + L + ++ C P+ +EV+
Sbjct: 787 K--FKENPHLIIMNVSDCIPDAIEVV 810
>gi|28610147 interleukin 6 signal transducer isoform 1 precursor
[Homo sapiens]
Length = 918
Score = 187 bits (475), Expect = 5e-47
Identities = 166/667 (24%), Positives = 282/667 (42%), Gaps = 67/667 (10%)
Query: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313
+ P+ V+ + S+ T CV +EK + H N I + I ++ + ++
Sbjct: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88
Query: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355
V FT E N++G I +G PP+ P+ L+C ++ K++ C W+
Sbjct: 89 VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148
Query: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413
GR T L T++TL + + K+ K + + PT+ + N E++ + A
Sbjct: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201
Query: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470
N LG+ S I + KV P+ P + V + S+ +KL+W P + I I+
Sbjct: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
Query: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528
+ K S Q SS+ V L P+T Y FRIRC E WS WS +
Sbjct: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
Query: 529 LTTEASPSKGPDTWRE----WSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSL 584
+T E PSK P W + + + + + WK LP EANGKIL Y V+ + L
Sbjct: 320 ITYEDRPSKAPSFWYKIDPSHTQGYRTVQLVWKTLPPFEANGKILDYEVTLT--RWKSHL 377
Query: 585 SEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKG-- 642
K + L + Y+ ++ +N VG S A + IP D + V K
Sbjct: 378 QNYTVNATKLTVNLTNDRYLATLTVRNLVGK---SDAAVLTIPACDFQATHPVMDLKAFP 434
Query: 643 ----ILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYN 698
+ + W Y+++WC S PC+ DW++ T + + Y
Sbjct: 435 KDNMLWVEWTTPRESVKKYILEWCVLSDKAPCITDWQQEDGTVHRTYLRGN-LAESKCYL 493
Query: 699 FFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRG 758
+ G S+ Y+++ P P + + +++W+ +PV+ GF+R
Sbjct: 494 ITVTPVYADGPGSPESIKAYLKQAPPSKGPTVRTKKVGKNEAVLEWDQLPVDVQNGFIRN 553
Query: 759 YLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818
Y ++ R + + + V D S ++ L T Y + + AYTD G
Sbjct: 554 YTIFY----------RTIIGNETAVNV----DSSHTEYTLSSLTSDTLYMVRMAAYTDEG 599
Query: 819 VGPEKSMYVVTKENSVGLIIAILIPVAVAVIVGVVTSIL-CYRKREWIKETFYPDIPNPE 877
T + + G I AI++PV +A ++ + +L C+ KR+ IK+ +P++P+P
Sbjct: 600 GKDGPEFTFTTPKFAQGEIEAIVVPVCLAFLLTTLLGVLFCFNKRDLIKKHIWPNVPDPS 659
Query: 878 NCKALQF 884
Q+
Sbjct: 660 KSHIAQW 666
>gi|115430248 gp130-like monocyte receptor [Homo sapiens]
Length = 764
Score = 135 bits (340), Expect = 2e-31
Identities = 130/569 (22%), Positives = 235/569 (41%), Gaps = 55/569 (9%)
Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFS-GKYVRLKRAEAPTNE 391
P P+ ++C + K + C+W+PG+ T+ T YT+ +++ G+ + T+E
Sbjct: 54 PAKPENISCVYYYRKNLTCTWSPGKETSY-----TQYTVKRTYAFGEKHDNCTTNSSTSE 108
Query: 392 SYQLLFQMLPNQEI---YNFTLNAHNPLGRSQSTILVNITEKVYPHTPTS-FKVKDINST 447
+ LP I Y + A N G +S + E + P F+VK +
Sbjct: 109 NRASCSFFLPRITIPDNYTIEVEAENGDGVIKSHMTYWRLENIAKTEPPKIFRVKPVLGI 168
Query: 448 A--VKLSW---HLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPY 502
+++ W L + + + S S E + +N +Y L L P+
Sbjct: 169 KRMIQIEWIKPELAPVSSDLKYTLRFRTVNSTSWMEVNFAKNRKDKNQTY--NLTGLQPF 226
Query: 503 TLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWR---EWSSDGKNLI-IYWKP 558
T Y +RC+ + WS WS +K +T E +P G + WR +DG+ + + WK
Sbjct: 227 TEYVIALRCAVKESKFWSDWSQEKMGMTEEEAPC-GLELWRVLKPAEADGRRPVRLLWKK 285
Query: 559 LPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPP 618
K L YN+ + T + + E+ L + +S+++ NS+G SP
Sbjct: 286 ARGAPVLEKTLGYNIWYYPESNTNLTETMNTTNQQLELHLGGESFWVSMISYNSLGKSP- 344
Query: 619 SKIASMEIPNDDLKIEQVVGMGKG------ILLTWHYDPNMTCDYVIKWCNSSRSEPCLM 672
+A++ IP K Q + + + +++ W ++I+W SEP +
Sbjct: 345 --VATLRIPAIQEKSFQCIEVMQACVAEDQLVVKWQSSALDVNTWMIEWFPDVDSEPTTL 402
Query: 673 DWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTV 732
W V S +T I+ D+ +P YN +Y + S+ Y +E P P V
Sbjct: 403 SWESV-SQATNWTIQQDKLKPFWCYNISVYPMLHDKVGEPYSIQAYAKEGVPSEGPETKV 461
Query: 733 EDTSADSILVKWEDIPVEELRGFLRGYLFYF----GKGERDTSKMRVLESGRSDIKVKNI 788
E+ ++ + W++IP E +G + Y ++ GKG T +L+ G
Sbjct: 462 ENIGVKTVTITWKEIPKSERKGIICNYTIFYQAEGGKGFSKTVNSSILQYG--------- 512
Query: 789 TDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIPVAVAV 848
+ L+ KTSY + + A T G S+ T SV II I + +
Sbjct: 513 ---------LESLKRKTSYIVQVMASTSAGGTNGTSINFKTLSFSVFEIILITSLIGGGL 563
Query: 849 IVGVVTSILC-YRKREWIKETFYPDIPNP 876
++ ++ ++ +K + +P +PNP
Sbjct: 564 LILIILTVAYGLKKPNKLTHLCWPTVPNP 592
>gi|4504643 interleukin 12 receptor, beta 2 precursor [Homo sapiens]
Length = 862
Score = 126 bits (316), Expect = 1e-28
Identities = 156/596 (26%), Positives = 251/596 (42%), Gaps = 70/596 (11%)
Query: 319 EDNIFGTVIFAGYPPDTPQQLNC-ETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSG 377
E I G IF G P+ PQ L+C + + + C+W GR T L T YTL S
Sbjct: 110 EIQICGAEIFVGVAPEQPQNLSCIQKGEQGTVACTWERGRDTHLY----TEYTLQLSGPK 165
Query: 378 KYVRLKRAEAPTNESYQLLFQMLPNQEIYNFT--LNAHNPLGRSQST-ILVNITEKVYPH 434
K+ + + + P NFT + A N LG S S + V P
Sbjct: 166 NLTWQKQCKDIYCDYLDFGINLTPESPESNFTAKVTAVNSLGSSSSLPSTFTFLDIVRPL 225
Query: 435 TPTSFKVKDINSTAVK--LSWHLPGNFAKINFLCEIEIKKSNS-VQEQRNVT-IKGVENS 490
P ++K ++ + L W G + L + + SNS + NVT KG +
Sbjct: 226 PPWDIRIKFQKASVSRCTLYWRDEG----LVLLNRLRYRPSNSRLWNMVNVTKAKGRHD- 280
Query: 491 SYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW---REWS 546
L L P+T Y F+I + WS WS + T E P+ D W R
Sbjct: 281 -----LLDLKPFTEYEFQISSKLHLYKGSWSDWSESLRAQTPEEEPTGMLDVWYMKRHID 335
Query: 547 SDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE-IPDPQHKAEIRLDKNDYII 605
+ + ++WK L ++EA GKIL Y V+ +++++ I + ++ +
Sbjct: 336 YSRQQISLFWKNLSVSEARGKILHYQVTLQELTGGKAMTQNITGHTSWTTVIPRTGNWAV 395
Query: 606 SVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGK----GILLTWH---YDPNMTCDYV 658
+V A NS GSS P++I M + L + V IL+TW DP+ +YV
Sbjct: 396 AVSAANSKGSSLPTRINIMNLCEAGLLAPRQVSANSEGMDNILVTWQPPRKDPSAVQEYV 455
Query: 659 IKW--CNSSRSEPCLMDW-RKVPSNSTETVIESDEFRPGIRYNFFLYGCR-NQGYQLLRS 714
++W + ++W R P N + + S+ + I Y +Y +QG S
Sbjct: 456 VEWRELHPGGDTQVPLNWLRSRPYNVSALI--SENIKSYICYEIRVYALSGDQGG--CSS 511
Query: 715 MIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMR 774
++G + AP+ P+ SIL+ W IPV+E G L Y Y+ ERD++
Sbjct: 512 ILGNSKHKAPLSGPHINAITEEKGSILISWNSIPVQEQMGCLLHYRIYW--KERDSNSQP 569
Query: 775 VLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV---GPEKSMYVVTKE 831
L +I + +SQ + I LQ + +Y L + A T G G E+ + K
Sbjct: 570 QL----CEIPYR----VSQNSHPINSLQPRVTYVLWMTALTAAGESSHGNEREFCLQGKA 621
Query: 832 NSVGLIIAILIPVAVAVIVGVVTS---------ILCYRKREWIKETFYPDIPNPEN 878
N + +A I +A+ ++VG+ ++ +L + +W +IP+P N
Sbjct: 622 NWMA-FVAPSICIAI-IMVGIFSTHYFQQKVFVLLAALRPQWCSR----EIPDPAN 671
>gi|27437045 colony stimulating factor 3 receptor isoform d
precursor [Homo sapiens]
Length = 783
Score = 102 bits (253), Expect = 3e-21
Identities = 133/582 (22%), Positives = 221/582 (37%), Gaps = 69/582 (11%)
Query: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
AGYPP P L+C + +IC W PG T L TS+TL +SF + + ++
Sbjct: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173
Query: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
+ + LL+Q N I+ + A N LG S S L V
Sbjct: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227
Query: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
P + D + A ++L W IN CE+ K V +
Sbjct: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287
Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
E Y L L P T YT +IRC WS WS + TTE +P+ DTW R+
Sbjct: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345
Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
D + + ++WKP+P+ E +G+I Y VS + ++ + + + L
Sbjct: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405
Query: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
+++VA NS G+S P+ + E L ++ + + + W YVI+W
Sbjct: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465
Query: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
NS+++ WR + + + RP Y + + +
Sbjct: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519
Query: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
Y +E+AP AP ++ ++W P E + L Y ++ + +
Sbjct: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573
Query: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV--GPEKSMYVVTKENSV 834
I + S + + L+ + YH+ L A + G ++ +T E S
Sbjct: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE 625
Query: 835 GLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNP 876
II L + + + T+ LC K +P +P+P
Sbjct: 626 LHIILGLFGLLLLLTCLCGTAWLCCSPNR--KNPLWPSVPDP 665
>gi|24496783 colony stimulating factor 3 receptor isoform c
precursor [Homo sapiens]
Length = 863
Score = 102 bits (253), Expect = 3e-21
Identities = 133/582 (22%), Positives = 221/582 (37%), Gaps = 69/582 (11%)
Query: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
AGYPP P L+C + +IC W PG T L TS+TL +SF + + ++
Sbjct: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173
Query: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
+ + LL+Q N I+ + A N LG S S L V
Sbjct: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227
Query: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
P + D + A ++L W IN CE+ K V +
Sbjct: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287
Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
E Y L L P T YT +IRC WS WS + TTE +P+ DTW R+
Sbjct: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345
Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
D + + ++WKP+P+ E +G+I Y VS + ++ + + + L
Sbjct: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405
Query: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
+++VA NS G+S P+ + E L ++ + + + W YVI+W
Sbjct: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465
Query: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
NS+++ WR + + + RP Y + + +
Sbjct: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519
Query: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
Y +E+AP AP ++ ++W P E + L Y ++ + +
Sbjct: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573
Query: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV--GPEKSMYVVTKENSV 834
I + S + + L+ + YH+ L A + G ++ +T E S
Sbjct: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE 625
Query: 835 GLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNP 876
II L + + + T+ LC K +P +P+P
Sbjct: 626 LHIILGLFGLLLLLTCLCGTAWLCCSPNR--KNPLWPSVPDP 665
>gi|4503081 colony stimulating factor 3 receptor isoform a precursor
[Homo sapiens]
Length = 836
Score = 102 bits (253), Expect = 3e-21
Identities = 133/582 (22%), Positives = 221/582 (37%), Gaps = 69/582 (11%)
Query: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
AGYPP P L+C + +IC W PG T L TS+TL +SF + + ++
Sbjct: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173
Query: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
+ + LL+Q N I+ + A N LG S S L V
Sbjct: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227
Query: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
P + D + A ++L W IN CE+ K V +
Sbjct: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287
Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
E Y L L P T YT +IRC WS WS + TTE +P+ DTW R+
Sbjct: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345
Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
D + + ++WKP+P+ E +G+I Y VS + ++ + + + L
Sbjct: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405
Query: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
+++VA NS G+S P+ + E L ++ + + + W YVI+W
Sbjct: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465
Query: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
NS+++ WR + + + RP Y + + +
Sbjct: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519
Query: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
Y +E+AP AP ++ ++W P E + L Y ++ + +
Sbjct: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573
Query: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGV--GPEKSMYVVTKENSV 834
I + S + + L+ + YH+ L A + G ++ +T E S
Sbjct: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTPEGSE 625
Query: 835 GLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYPDIPNP 876
II L + + + T+ LC K +P +P+P
Sbjct: 626 LHIILGLFGLLLLLTCLCGTAWLCCSPNR--KNPLWPSVPDP 665
>gi|27437042 colony stimulating factor 3 receptor isoform b
precursor [Homo sapiens]
Length = 769
Score = 96.3 bits (238), Expect = 1e-19
Identities = 120/522 (22%), Positives = 198/522 (37%), Gaps = 65/522 (12%)
Query: 329 AGYPPDTPQQLNCETH-DLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEA 387
AGYPP P L+C + +IC W PG T L TS+TL +SF + + ++
Sbjct: 119 AGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHL----PTSFTL-KSFKSRGNCQTQGDS 173
Query: 388 PTN-------------ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH 434
+ + LL+Q N I+ + A N LG S S L V
Sbjct: 174 ILDCVPKDGQSHCCIPRKHLLLYQ---NMGIW---VQAENALGTSMSPQLCLDPMDVVKL 227
Query: 435 TPTSFKVKDINSTA-------VKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV 487
P + D + A ++L W IN CE+ K V +
Sbjct: 228 EPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPL 287
Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETF-WKWSKWSNKKQHLTTEASPSKGPDTW-REW 545
E Y L L P T YT +IRC WS WS + TTE +P+ DTW R+
Sbjct: 288 EALQY--ELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQR 345
Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD-PQHKAEIRLDKNDYI 604
D + + ++WKP+P+ E +G+I Y VS + ++ + + + L
Sbjct: 346 QLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQE 405
Query: 605 ISVVAKNSVGSSPPSKIASMEIPNDDL-KIEQVVGMGKGILLTWHYDPNMTCDYVIKW-- 661
+++VA NS G+S P+ + E L ++ + + + W YVI+W
Sbjct: 406 VALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGL 465
Query: 662 -----CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
NS+++ WR + + + RP Y + + +
Sbjct: 466 GPPSASNSNKT------WRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVY 519
Query: 717 GYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVL 776
Y +E+AP AP ++ ++W P E + L Y ++ + +
Sbjct: 520 AYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQS------ 573
Query: 777 ESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGG 818
I + S + + L+ + YH+ L A + G
Sbjct: 574 --------FSAILNASSRGFVLHGLEPASLYHIHLMAASQAG 607
>gi|28610149 interleukin 6 signal transducer isoform 2 precursor
[Homo sapiens]
Length = 329
Score = 83.6 bits (205), Expect = 1e-15
Identities = 81/304 (26%), Positives = 132/304 (43%), Gaps = 36/304 (11%)
Query: 254 VFPQDKVILVGSDITFCCVSQEKVLSALIGHTNCPLIHLDGENVAIKIRNISVSASSGTN 313
+ P+ V+ + S+ T CV +EK + H N I + I ++ + ++
Sbjct: 31 ISPESPVVQLHSNFTAVCVLKEKCMDYF--HVNANYIVWKTNHFTIPKEQYTIINRTASS 88
Query: 314 VVFTT------------------EDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNP 355
V FT E N++G I +G PP+ P+ L+C ++ K++ C W+
Sbjct: 89 VTFTDIASLNIQLTCNILTFGQLEQNVYGITIISGLPPEKPKNLSCIVNEGKKMRCEWDG 148
Query: 356 GRVTALVGPRATSYTLVESF-SGKYVRLK-RAEAPTNESYQLLFQMLPNQEIYNFTLNAH 413
GR T L T++TL + + K+ K + + PT+ + N E++ + A
Sbjct: 149 GRETHL----ETNFTLKSEWATHKFADCKAKRDTPTSCTVDYSTVYFVNIEVW---VEAE 201
Query: 414 NPLGRSQST-ILVNITEKVYPHTPTSFKV--KDINSTAVKLSWHLPGNFAKINFLCEIEI 470
N LG+ S I + KV P+ P + V + S+ +KL+W P + I I+
Sbjct: 202 NALGKVTSDHINFDPVYKVKPNPPHNLSVINSEELSSILKLTWTNPSIKSVIILKYNIQY 261
Query: 471 K-KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQH 528
+ K S Q SS+ V L P+T Y FRIRC E WS WS +
Sbjct: 262 RTKDASTWSQIPPEDTASTRSSFTV--QDLKPFTEYVFRIRCMKEDGKGYWSDWSEEASG 319
Query: 529 LTTE 532
+T E
Sbjct: 320 ITYE 323
>gi|51093381 leptin receptor isoform 3 [Homo sapiens]
Length = 958
Score = 74.3 bits (181), Expect = 6e-13
Identities = 108/508 (21%), Positives = 210/508 (41%), Gaps = 54/508 (10%)
Query: 235 WSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCV--SQEKVLSA--LIGHTNC--- 287
WSDWS + + FP + VGS+++F C+ + K++ + ++ N
Sbjct: 319 WSDWSTPRVFT---TQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEK 375
Query: 288 -PLIHLD--GENVA-IKIRNISVSASSGT---NVVFTTEDNIFGTVIFAGYPPDTPQQLN 340
P D ++V+ + N++ + G + V+ ++ Y D ++
Sbjct: 376 IPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINIS 435
Query: 341 CETHD-LKEIICSWNPGRVTALVGP-------RATSYTLVESFSGKYVRLKRAEAPTNES 392
CET L ++ C W+ + +L R++ Y K ++
Sbjct: 436 CETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF 495
Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVY-PHTPTSFKVK-DINSTAVK 450
Y+ +FQ + Y + ++ LG S + + V P P+S K + IN +K
Sbjct: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
Query: 451 LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIR 510
+SW P F + N +I S + + + ++ S V+L + +Y ++R
Sbjct: 556 ISWEKPV-FPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKS--VSLPVPDLCAVYAVQVR 612
Query: 511 CST-ETFWKWSKWSNKKQHLTTEAS-PSKGPDTWREWSSDG----KNLIIYWKPLPINEA 564
C + WS WSN + + P +GP+ WR + D KN+ + WKPL N++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDS 672
Query: 565 ----NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSK 620
+++++ SC+ + SE K + + ++V+A NS+G+S +
Sbjct: 673 LCSVQRYVINHHTSCNG-----TWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANF 727
Query: 621 IASMEIPNDDLKIEQVVGM----GKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDW 674
+ P + I Q + ++++W P+ ++I+W N +E + W
Sbjct: 728 NLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN--LNEDGEIKW 785
Query: 675 RKVPSNSTETVIESDEFRPGIRYNFFLY 702
++ S+S + D F P +Y F LY
Sbjct: 786 LRI-SSSVKKYYIHDHFIPIEKYQFSLY 812
Score = 38.1 bits (87), Expect = 0.046
Identities = 27/89 (30%), Positives = 51/89 (57%), Gaps = 14/89 (15%)
Query: 818 GVGPEKSMYVVTKEN------SVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYP 871
GVG K + T+++ GL + ++PV ++ + ++ ++L +R +K+ F+
Sbjct: 818 GVGKPKIINSFTQDDIEKHQSDAGLYV--IVPVIISSSILLLGTLLISHQR--MKKLFWE 873
Query: 872 DIPNPENC---KALQFQKSVCEGSSALKT 897
D+PNP+NC + L FQK + EGS +K+
Sbjct: 874 DVPNPKNCSWAQGLNFQK-MLEGSMFVKS 901
>gi|51093379 leptin receptor isoform 2 [Homo sapiens]
Length = 896
Score = 74.3 bits (181), Expect = 6e-13
Identities = 108/508 (21%), Positives = 210/508 (41%), Gaps = 54/508 (10%)
Query: 235 WSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCV--SQEKVLSA--LIGHTNC--- 287
WSDWS + + FP + VGS+++F C+ + K++ + ++ N
Sbjct: 319 WSDWSTPRVFT---TQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEK 375
Query: 288 -PLIHLD--GENVA-IKIRNISVSASSGT---NVVFTTEDNIFGTVIFAGYPPDTPQQLN 340
P D ++V+ + N++ + G + V+ ++ Y D ++
Sbjct: 376 IPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINIS 435
Query: 341 CETHD-LKEIICSWNPGRVTALVGP-------RATSYTLVESFSGKYVRLKRAEAPTNES 392
CET L ++ C W+ + +L R++ Y K ++
Sbjct: 436 CETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF 495
Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVY-PHTPTSFKVK-DINSTAVK 450
Y+ +FQ + Y + ++ LG S + + V P P+S K + IN +K
Sbjct: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
Query: 451 LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIR 510
+SW P F + N +I S + + + ++ S V+L + +Y ++R
Sbjct: 556 ISWEKPV-FPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKS--VSLPVPDLCAVYAVQVR 612
Query: 511 CST-ETFWKWSKWSNKKQHLTTEAS-PSKGPDTWREWSSDG----KNLIIYWKPLPINEA 564
C + WS WSN + + P +GP+ WR + D KN+ + WKPL N++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDS 672
Query: 565 ----NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSK 620
+++++ SC+ + SE K + + ++V+A NS+G+S +
Sbjct: 673 LCSVQRYVINHHTSCNG-----TWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANF 727
Query: 621 IASMEIPNDDLKIEQVVGM----GKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDW 674
+ P + I Q + ++++W P+ ++I+W N +E + W
Sbjct: 728 NLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN--LNEDGEIKW 785
Query: 675 RKVPSNSTETVIESDEFRPGIRYNFFLY 702
++ S+S + D F P +Y F LY
Sbjct: 786 LRI-SSSVKKYYIHDHFIPIEKYQFSLY 812
Score = 35.4 bits (80), Expect = 0.30
Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 13/78 (16%)
Query: 818 GVGPEKSMYVVTKEN------SVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYP 871
GVG K + T+++ GL + ++PV ++ + ++ ++L +R +K+ F+
Sbjct: 818 GVGKPKIINSFTQDDIEKHQSDAGLYV--IVPVIISSSILLLGTLLISHQR--MKKLFWE 873
Query: 872 DIPNPENC---KALQFQK 886
D+PNP+NC + L FQK
Sbjct: 874 DVPNPKNCSWAQGLNFQK 891
>gi|40254464 leptin receptor isoform 1 [Homo sapiens]
Length = 1165
Score = 74.3 bits (181), Expect = 6e-13
Identities = 108/508 (21%), Positives = 210/508 (41%), Gaps = 54/508 (10%)
Query: 235 WSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCV--SQEKVLSA--LIGHTNC--- 287
WSDWS + + FP + VGS+++F C+ + K++ + ++ N
Sbjct: 319 WSDWSTPRVFT---TQDVIYFPPKILTSVGSNVSFHCIYKKENKIVPSKEIVWWMNLAEK 375
Query: 288 -PLIHLD--GENVA-IKIRNISVSASSGT---NVVFTTEDNIFGTVIFAGYPPDTPQQLN 340
P D ++V+ + N++ + G + V+ ++ Y D ++
Sbjct: 376 IPQSQYDVVSDHVSKVTFFNLNETKPRGKFTYDAVYCCNEHECHHRYAELYVIDVNINIS 435
Query: 341 CETHD-LKEIICSWNPGRVTALVGP-------RATSYTLVESFSGKYVRLKRAEAPTNES 392
CET L ++ C W+ + +L R++ Y K ++
Sbjct: 436 CETDGYLTKMTCRWSTSTIQSLAESTLQLRYHRSSLYCSDIPSIHPISEPKDCYLQSDGF 495
Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVY-PHTPTSFKVK-DINSTAVK 450
Y+ +FQ + Y + ++ LG S + + V P P+S K + IN +K
Sbjct: 496 YECIFQPIFLLSGYTMWIRINHSLGSLDSPPTCVLPDSVVKPLPPSSVKAEITINIGLLK 555
Query: 451 LSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIR 510
+SW P F + N +I S + + + ++ S V+L + +Y ++R
Sbjct: 556 ISWEKPV-FPENNLQFQIRYGLSGKEVQWKMYEVYDAKSKS--VSLPVPDLCAVYAVQVR 612
Query: 511 CST-ETFWKWSKWSNKKQHLTTEAS-PSKGPDTWREWSSDG----KNLIIYWKPLPINEA 564
C + WS WSN + + P +GP+ WR + D KN+ + WKPL N++
Sbjct: 613 CKRLDGLGYWSNWSNPAYTVVMDIKVPMRGPEFWRIINGDTMKKEKNVTLLWKPLMKNDS 672
Query: 565 ----NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVGSSPPSK 620
+++++ SC+ + SE K + + ++V+A NS+G+S +
Sbjct: 673 LCSVQRYVINHHTSCNG-----TWSEDVGNHTKFTFLWTEQAHTVTVLAINSIGASVANF 727
Query: 621 IASMEIPNDDLKIEQVVGM----GKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDW 674
+ P + I Q + ++++W P+ ++I+W N +E + W
Sbjct: 728 NLTFSWPMSKVNIVQSLSAYPLNSSCVIVSWILSPSDYKLMYFIIEWKN--LNEDGEIKW 785
Query: 675 RKVPSNSTETVIESDEFRPGIRYNFFLY 702
++ S+S + D F P +Y F LY
Sbjct: 786 LRI-SSSVKKYYIHDHFIPIEKYQFSLY 812
Score = 35.4 bits (80), Expect = 0.30
Identities = 23/78 (29%), Positives = 44/78 (56%), Gaps = 13/78 (16%)
Query: 818 GVGPEKSMYVVTKEN------SVGLIIAILIPVAVAVIVGVVTSILCYRKREWIKETFYP 871
GVG K + T+++ GL + ++PV ++ + ++ ++L +R +K+ F+
Sbjct: 818 GVGKPKIINSFTQDDIEKHQSDAGLYV--IVPVIISSSILLLGTLLISHQR--MKKLFWE 873
Query: 872 DIPNPENC---KALQFQK 886
D+PNP+NC + L FQK
Sbjct: 874 DVPNPKNCSWAQGLNFQK 891
>gi|4506309 protein tyrosine phosphatase, receptor type, D isoform 1
precursor [Homo sapiens]
Length = 1912
Score = 67.8 bits (164), Expect = 5e-11
Identities = 93/403 (23%), Positives = 168/403 (41%), Gaps = 43/403 (10%)
Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
Q+ Y+ + A +G S+ + IT+ P P +FK + + T++ LSW P +
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 544
Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSK 521
N+ E+ K +EQR +TI+ +SY L L P +LY FR+ + S
Sbjct: 545 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRLAARSPQGLGAST 597
Query: 522 WSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSS---- 577
+ T ++ PS P S ++++ W+P P+ + NG I Y++ ++
Sbjct: 598 AEISAR--TMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 578 DEETQSLSEIPDPQHKAEI-RLDK-NDYIISVVAKNSVGSSPPSKIASMEIPNDDL---- 631
D++ + IP K + +L+K +Y I+V A VG P S ++ + N+D+
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES-LSVLIRTNEDVPSGP 714
Query: 632 --KIEQVVGMGKGILLTWHYD-PN----MTCDYVIKWCNSSRSEP---------CLMDWR 675
K+E + ++W PN Y + + EP L D +
Sbjct: 715 PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ 774
Query: 676 KVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVA-PNFTVED 734
++TE + +P Y+ + +G RS + + P +
Sbjct: 775 WEFDDTTEHDMIISGLQPETSYSLTVTAYTTKG-DGARSKPKLVSTTGAVPGKPRLVINH 833
Query: 735 TSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLE 777
T ++ L++W P + G L+GY FG+ +D + LE
Sbjct: 834 TQMNTALIQWH--PPVDTFGPLQGYRLKFGR--KDMEPLTTLE 872
Score = 51.2 bits (121), Expect = 5e-06
Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRV---TALVGPRATSYTLVESFSGKYVRLKRAEAP 388
P PQ ++C + I+ SW P V ++ + YT V+ K + +
Sbjct: 609 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 668
Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINS 446
T + L + L Y T+ AH +G + +L+ E V P +V+ +NS
Sbjct: 669 TTK---YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 725
Query: 447 TAVKLSWHLP 456
T+VK+SW P
Sbjct: 726 TSVKVSWRSP 735
Score = 50.1 bits (118), Expect = 1e-05
Identities = 82/447 (18%), Positives = 173/447 (38%), Gaps = 30/447 (6%)
Query: 406 YNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKIN 463
Y F + A N +GR + +L +E+ P + + ++ST + + W P
Sbjct: 389 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEE--PNG 446
Query: 464 FLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWS 523
+ + + + N +K S + + L P Y+ ++ T S
Sbjct: 447 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI--GDGPLS 504
Query: 524 NKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDE--ET 581
+ Q +T P + P ++ ++++ W P + I +Y + E E
Sbjct: 505 SDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP----PRSDTIANYELVYKDGEHGEE 559
Query: 582 QSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVG-SSPPSKIASMEIPNDDLKIEQVVGM- 639
Q ++ P ++ + + Y + A++ G + ++I++ + + Q +
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
Query: 640 ---GKGILLTWHYDP-----NMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEF 691
IL++W P + +Y IK+ + + +PS++T+ ++E E
Sbjct: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
Query: 692 RPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEE 751
R + G + L +I E++ VE ++ S+ V W +
Sbjct: 680 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739
Query: 752 LRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKN----ITDISQKTLRIADLQGKTSY 807
G +RGY ++ + E K + + D+ + + D ++ + I+ LQ +TSY
Sbjct: 740 QHGQIRGYQVHYVRMENGEPKGQPM---LKDVMLADAQWEFDDTTEHDMIISGLQPETSY 796
Query: 808 HLVLRAYTDGGVGPEKSMYVVTKENSV 834
L + AYT G G +V+ +V
Sbjct: 797 SLTVTAYTTKGDGARSKPKLVSTTGAV 823
Score = 31.6 bits (70), Expect = 4.3
Identities = 34/130 (26%), Positives = 52/130 (40%), Gaps = 5/130 (3%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLV-ESFSGKYVRLKRAEAPTN 390
P PQ L+ E + SW P V A T YTL+ + + +++ P +
Sbjct: 918 PTGFPQNLHSEGTTSTSVQLSWQPP-VLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 976
Query: 391 ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAV 449
+ L L Y+ + AH G + V T V +F VK + T+V
Sbjct: 977 TTMTLTG--LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1034
Query: 450 KLSWHLPGNF 459
LSW +P N+
Sbjct: 1035 LLSWEIPENY 1044
>gi|18860890 protein tyrosine phosphatase, receptor type, D isoform
2 precursor [Homo sapiens]
Length = 1899
Score = 67.8 bits (164), Expect = 5e-11
Identities = 93/403 (23%), Positives = 168/403 (41%), Gaps = 43/403 (10%)
Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
Q+ Y+ + A +G S+ + IT+ P P +FK + + T++ LSW P +
Sbjct: 472 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 531
Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSK 521
N+ E+ K +EQR +TI+ +SY L L P +LY FR+ + S
Sbjct: 532 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRLAARSPQGLGAST 584
Query: 522 WSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSS---- 577
+ T ++ PS P S ++++ W+P P+ + NG I Y++ ++
Sbjct: 585 AEISAR--TMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 642
Query: 578 DEETQSLSEIPDPQHKAEI-RLDK-NDYIISVVAKNSVGSSPPSKIASMEIPNDDL---- 631
D++ + IP K + +L+K +Y I+V A VG P S ++ + N+D+
Sbjct: 643 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES-LSVLIRTNEDVPSGP 701
Query: 632 --KIEQVVGMGKGILLTWHYD-PN----MTCDYVIKWCNSSRSEP---------CLMDWR 675
K+E + ++W PN Y + + EP L D +
Sbjct: 702 PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKDVMLADAQ 761
Query: 676 KVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVA-PNFTVED 734
++TE + +P Y+ + +G RS + + P +
Sbjct: 762 WEFDDTTEHDMIISGLQPETSYSLTVTAYTTKG-DGARSKPKLVSTTGAVPGKPRLVINH 820
Query: 735 TSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLE 777
T ++ L++W P + G L+GY FG+ +D + LE
Sbjct: 821 TQMNTALIQWH--PPVDTFGPLQGYRLKFGR--KDMEPLTTLE 859
Score = 51.2 bits (121), Expect = 5e-06
Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRV---TALVGPRATSYTLVESFSGKYVRLKRAEAP 388
P PQ ++C + I+ SW P V ++ + YT V+ K + +
Sbjct: 596 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 655
Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINS 446
T + L + L Y T+ AH +G + +L+ E V P +V+ +NS
Sbjct: 656 TTK---YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 712
Query: 447 TAVKLSWHLP 456
T+VK+SW P
Sbjct: 713 TSVKVSWRSP 722
Score = 50.1 bits (118), Expect = 1e-05
Identities = 82/447 (18%), Positives = 173/447 (38%), Gaps = 30/447 (6%)
Query: 406 YNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKIN 463
Y F + A N +GR + +L +E+ P + + ++ST + + W P
Sbjct: 376 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEE--PNG 433
Query: 464 FLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWS 523
+ + + + N +K S + + L P Y+ ++ T S
Sbjct: 434 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI--GDGPLS 491
Query: 524 NKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDE--ET 581
+ Q +T P + P ++ ++++ W P + I +Y + E E
Sbjct: 492 SDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP----PRSDTIANYELVYKDGEHGEE 546
Query: 582 QSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVG-SSPPSKIASMEIPNDDLKIEQVVGM- 639
Q ++ P ++ + + Y + A++ G + ++I++ + + Q +
Sbjct: 547 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 606
Query: 640 ---GKGILLTWHYDP-----NMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEF 691
IL++W P + +Y IK+ + + +PS++T+ ++E E
Sbjct: 607 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 666
Query: 692 RPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEE 751
R + G + L +I E++ VE ++ S+ V W +
Sbjct: 667 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 726
Query: 752 LRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKN----ITDISQKTLRIADLQGKTSY 807
G +RGY ++ + E K + + D+ + + D ++ + I+ LQ +TSY
Sbjct: 727 QHGQIRGYQVHYVRMENGEPKGQPM---LKDVMLADAQWEFDDTTEHDMIISGLQPETSY 783
Query: 808 HLVLRAYTDGGVGPEKSMYVVTKENSV 834
L + AYT G G +V+ +V
Sbjct: 784 SLTVTAYTTKGDGARSKPKLVSTTGAV 810
Score = 31.6 bits (70), Expect = 4.3
Identities = 34/130 (26%), Positives = 52/130 (40%), Gaps = 5/130 (3%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLV-ESFSGKYVRLKRAEAPTN 390
P PQ L+ E + SW P V A T YTL+ + + +++ P +
Sbjct: 905 PTGFPQNLHSEGTTSTSVQLSWQPP-VLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 963
Query: 391 ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAV 449
+ L L Y+ + AH G + V T V +F VK + T+V
Sbjct: 964 TTMTLTG--LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1021
Query: 450 KLSWHLPGNF 459
LSW +P N+
Sbjct: 1022 LLSWEIPENY 1031
>gi|18860892 protein tyrosine phosphatase, receptor type, D isoform
3 precursor [Homo sapiens]
Length = 1903
Score = 67.4 bits (163), Expect = 7e-11
Identities = 89/397 (22%), Positives = 166/397 (41%), Gaps = 40/397 (10%)
Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
Q+ Y+ + A +G S+ + IT+ P P +FK + + T++ LSW P +
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 544
Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSK 521
N+ E+ K +EQR +TI+ +SY L L P +LY FR+ + S
Sbjct: 545 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRLAARSPQGLGAST 597
Query: 522 WSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSS---- 577
+ T ++ PS P S ++++ W+P P+ + NG I Y++ ++
Sbjct: 598 AEISAR--TMQSKPSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGE 655
Query: 578 DEETQSLSEIPDPQHKAEI-RLDK-NDYIISVVAKNSVGSSPPSKIASMEIPNDDL---- 631
D++ + IP K + +L+K +Y I+V A VG P S ++ + N+D+
Sbjct: 656 DDKPHEILGIPSDTTKYLLEQLEKWTEYRITVTAHTDVGPGPES-LSVLIRTNEDVPSGP 714
Query: 632 --KIEQVVGMGKGILLTWHYD-PN--------MTCDYVIKWCNSSRSEPCLMDWRKVPSN 680
K+E + ++W PN YV + +P L D + ++
Sbjct: 715 PRKVEVEAVNSTSVKVSWRSPVPNKQHGQIRGYQVHYVRMENGEPKGQPMLKD--VMLAD 772
Query: 681 STETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSI 740
+ + +I + Y + G + ++ + P + T ++
Sbjct: 773 AQDMIISGLQPETSYSLTVTAYTTKGDGARSKPKLVSTTGAVPG--KPRLVINHTQMNTA 830
Query: 741 LVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLE 777
L++W P + G L+GY FG+ +D + LE
Sbjct: 831 LIQWH--PPVDTFGPLQGYRLKFGR--KDMEPLTTLE 863
Score = 60.1 bits (144), Expect = 1e-08
Identities = 109/513 (21%), Positives = 187/513 (36%), Gaps = 57/513 (11%)
Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES 392
P P E I+ SW P R + +Y LV G++ +R S
Sbjct: 516 PGQPLNFKAEPESETSILLSWTPPRSDTIA-----NYELVYK-DGEHGEEQRITIEPGTS 569
Query: 393 YQLLFQMLPNQEIYNFTLNAHNP--LGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVK 450
Y+L Q L +Y F L A +P LG S + I + P +ST++
Sbjct: 570 YRL--QGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCTSPSSTSIL 627
Query: 451 LSWHLPGNFAKINFLCEIEIKKSN-SVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRI 509
+SW P + + E IK + ++ + I G+ + + L++L +T Y RI
Sbjct: 628 VSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEKWTEY--RI 685
Query: 510 RCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKIL 569
+ T S T E PS P + + ++ + W+ N+ +G+I
Sbjct: 686 TVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNKQHGQIR 745
Query: 570 SYNVSCSSDEETQSLSEIPDPQHKAEIRLDKNDYIIS-----------VVAKNSVGSSPP 618
Y V E + + P K + D D IIS V A + G
Sbjct: 746 GYQVHYVRMENGEPKGQ---PMLKDVMLADAQDMIISGLQPETSYSLTVTAYTTKGDGAR 802
Query: 619 SKIASME----IPNDDLKIEQVVGMGKGILLTWH-----YDPNMTCDYVIKWCNSSRSEP 669
SK + +P + M L+ WH + P Y +K+
Sbjct: 803 SKPKLVSTTGAVPGKPRLVINHTQMNTA-LIQWHPPVDTFGPLQ--GYRLKFGRKDMEPL 859
Query: 670 CLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSMIGYIEELAPIVAP 728
+++ + + T T I G Y F L G+ + + I EE+
Sbjct: 860 TTLEFSEKEDHFTATDIHK-----GASYVFRLSARNKVGFGEEMVKEISIPEEVPTGFPQ 914
Query: 729 NFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNI 788
N E T++ S+ + W+ + E G + Y + RD + + ++ +
Sbjct: 915 NLHSEGTTSTSVQLSWQPPVLAERNGIITKYTLLY----RDINIPL--------LPMEQL 962
Query: 789 TDISQKTLRIADLQGKTSYHLVLRAYTDGGVGP 821
+ T+ + L+ T+Y + +RA+T G GP
Sbjct: 963 IVPADTTMTLTGLKPDTTYDVKVRAHTSKGPGP 995
Score = 51.2 bits (121), Expect = 5e-06
Identities = 34/130 (26%), Positives = 56/130 (43%), Gaps = 8/130 (6%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRV---TALVGPRATSYTLVESFSGKYVRLKRAEAP 388
P PQ ++C + I+ SW P V ++ + YT V+ K + +
Sbjct: 609 PSAPPQDISCTSPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSD 668
Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINS 446
T + L + L Y T+ AH +G + +L+ E V P +V+ +NS
Sbjct: 669 TTK---YLLEQLEKWTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNS 725
Query: 447 TAVKLSWHLP 456
T+VK+SW P
Sbjct: 726 TSVKVSWRSP 735
Score = 50.4 bits (119), Expect = 9e-06
Identities = 81/443 (18%), Positives = 171/443 (38%), Gaps = 31/443 (6%)
Query: 406 YNFTLNAHNPLGRSQST--ILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKIN 463
Y F + A N +GR + +L +E+ P + + ++ST + + W P
Sbjct: 389 YEFRVVAVNNIGRGPPSEPVLTQTSEQAPSSAPRDVQARMLSSTTILVQWKEPEE--PNG 446
Query: 464 FLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWS 523
+ + + + N +K S + + L P Y+ ++ T S
Sbjct: 447 QIQGYRVYYTMDPTQHVNNWMKHNVADSQITTIGNLVPQKTYSVKVLAFTSI--GDGPLS 504
Query: 524 NKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDE--ET 581
+ Q +T P + P ++ ++++ W P + I +Y + E E
Sbjct: 505 SDIQVITQTGVPGQ-PLNFKAEPESETSILLSWTP----PRSDTIANYELVYKDGEHGEE 559
Query: 582 QSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVG-SSPPSKIASMEIPNDDLKIEQVVGM- 639
Q ++ P ++ + + Y + A++ G + ++I++ + + Q +
Sbjct: 560 QRITIEPGTSYRLQGLKPNSLYYFRLAARSPQGLGASTAEISARTMQSKPSAPPQDISCT 619
Query: 640 ---GKGILLTWHYDP-----NMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEF 691
IL++W P + +Y IK+ + + +PS++T+ ++E E
Sbjct: 620 SPSSTSILVSWQPPPVEKQNGIITEYSIKYTAVDGEDDKPHEILGIPSDTTKYLLEQLEK 679
Query: 692 RPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEE 751
R + G + L +I E++ VE ++ S+ V W +
Sbjct: 680 WTEYRITVTAHTDVGPGPESLSVLIRTNEDVPSGPPRKVEVEAVNSTSVKVSWRSPVPNK 739
Query: 752 LRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVL 811
G +RGY ++ + E K + + +K++ + + I+ LQ +TSY L +
Sbjct: 740 QHGQIRGYQVHYVRMENGEPKGQPM--------LKDVMLADAQDMIISGLQPETSYSLTV 791
Query: 812 RAYTDGGVGPEKSMYVVTKENSV 834
AYT G G +V+ +V
Sbjct: 792 TAYTTKGDGARSKPKLVSTTGAV 814
Score = 31.6 bits (70), Expect = 4.3
Identities = 34/130 (26%), Positives = 52/130 (40%), Gaps = 5/130 (3%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLV-ESFSGKYVRLKRAEAPTN 390
P PQ L+ E + SW P V A T YTL+ + + +++ P +
Sbjct: 909 PTGFPQNLHSEGTTSTSVQLSWQPP-VLAERNGIITKYTLLYRDINIPLLPMEQLIVPAD 967
Query: 391 ESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAV 449
+ L L Y+ + AH G + V T V +F VK + T+V
Sbjct: 968 TTMTLTG--LKPDTTYDVKVRAHTSKGPGPYSPSVQFRTLPVDQVFAKNFHVKAVMKTSV 1025
Query: 450 KLSWHLPGNF 459
LSW +P N+
Sbjct: 1026 LLSWEIPENY 1035
>gi|81158224 neuronal cell adhesion molecule isoform B precursor
[Homo sapiens]
Length = 1183
Score = 65.1 bits (157), Expect = 4e-10
Identities = 69/281 (24%), Positives = 118/281 (41%), Gaps = 24/281 (8%)
Query: 386 EAPTNESY-----QLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFK 440
E P++E + L+ + + + +T A+ L ++ ++++ + P+ P +
Sbjct: 581 ELPSDERFTVDKDHLVVADVSDDDSGTYTCVANTTLDSVSASAVLSVVD--VPNPPFDLE 638
Query: 441 VKDINSTAVKLSWHLPG---NFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALD 497
+ D +V+LSW PG N F+ E E + G + ++ L
Sbjct: 639 LTDQLDKSVQLSW-TPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQTTAQL---- 693
Query: 498 KLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWK 557
KL+PY Y+FR+ + + K +Q+LT + P K P S+ NL+I WK
Sbjct: 694 KLSPYVNYSFRVM-AVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEPDNLVITWK 752
Query: 558 PLPINEANGKILSYNVSC---SSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAKNSVG 614
PL E+NG L Y VS D+E S+ ++ Y+I V A N +G
Sbjct: 753 PLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIKVQALNDMG 812
Query: 615 SSPPSKIASMEIPNDDLKI----EQVVGMGKGILLTWHYDP 651
+P + M +DL + V + L H+DP
Sbjct: 813 FAPEPAVV-MGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDP 852
Score = 51.6 bits (122), Expect = 4e-06
Identities = 59/252 (23%), Positives = 107/252 (42%), Gaps = 26/252 (10%)
Query: 585 SEIPDPQHKAEIRLDKN-DYIISVVAKNSVGSSPPSKIASMEIPN---DDLKIEQVVGMG 640
+E+ Q A+++L +Y V+A NS+G S PS+ + + D V G+G
Sbjct: 682 TEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 741
Query: 641 K---GILLTWH----YDPNMT-CDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFR 692
+++TW ++ N Y + W + +W V + I S
Sbjct: 742 SEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDD----EWTSVVVANVSKYIVSGT-P 796
Query: 693 PGIRYNFFLYGCRNQGYQLLRSMI-GYIEELAPIVAP-NFTVEDTSADSILVKWEDIPVE 750
+ Y + + G+ +++ G+ E P+VAP N V ++ V W+ +P++
Sbjct: 797 TFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLK 856
Query: 751 ELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTL-RIADLQGKTSYHL 809
+RG L+GY Y+ K + + + R I+ K +T KT + L+ + Y L
Sbjct: 857 SIRGHLQGYRIYYWKTQSSSKR------NRRHIEKKILTFQGSKTHGMLPGLEPFSHYTL 910
Query: 810 VLRAYTDGGVGP 821
+R G GP
Sbjct: 911 NVRVVNGKGEGP 922
Score = 31.2 bits (69), Expect = 5.6
Identities = 38/188 (20%), Positives = 73/188 (38%), Gaps = 21/188 (11%)
Query: 554 IYWKPLPINEANGKILSYNV----SCSSDE------ETQSLSEIPDPQHKAEIRLDK-ND 602
++W P+P+ G + Y + + SS + E + L+ H L+ +
Sbjct: 848 VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 907
Query: 603 YIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGIL--LTWHYDP-----NMTC 655
Y ++V N G P S P + + L LT +DP +
Sbjct: 908 YTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILT 967
Query: 656 DYVIKW--CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLR 713
+Y +K+ NS+ L+D K+P+N T +++ F ++ F+ G Q+
Sbjct: 968 EYTLKYQPINSTHELGPLVDL-KIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE 1026
Query: 714 SMIGYIEE 721
+ ++E
Sbjct: 1027 EAVTTVDE 1034
>gi|148806908 fibronectin type III domain containing 1 [Homo
sapiens]
Length = 1894
Score = 63.5 bits (153), Expect = 1e-09
Identities = 74/321 (23%), Positives = 126/321 (39%), Gaps = 49/321 (15%)
Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRAT-SYTLVESFSGK---YVRLKRAEAP 388
P+ P ++ + D + +W R++ PR + + L SG+ YV L R E
Sbjct: 158 PNKPLRVRVRSSD-DRLSVAWKAPRLSGAKSPRRSRGFLLGYGESGRKMNYVPLTRDER- 215
Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH-----TPTSFKVKD 443
T+E + L ++ +Y +L + N GRSQ +T++ P V+
Sbjct: 216 THE-----IKKLASESVYVVSLQSMNSQGRSQPVYRAALTKRKISEEDELDVPDDISVRV 270
Query: 444 INSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYL---------- 493
++S +V +SW P ++K V R T++ E
Sbjct: 271 MSSQSVLVSWVDP------------VLEKQKKVVASRQYTVRYREKGELARWDYKQIANR 318
Query: 494 -VALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNL 552
V ++ L P T+Y F +R S + KWS T E++P+ P+ W +GK
Sbjct: 319 RVLIENLIPDTVYEFAVRISQGE--RDGKWSTSVFQRTPESAPTTAPENLNVWPVNGKPT 376
Query: 553 II--YWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLD----KNDYIIS 606
++ W LP E GK+ Y +S + + + P +D Y+
Sbjct: 377 VVAASWDALP--ETEGKVKEYILSYAPALKPFGAKSLTYPGDTTSALVDGLQPGERYLFK 434
Query: 607 VVAKNSVGSSPPSKIASMEIP 627
+ A N G P SK + +P
Sbjct: 435 IRATNRRGLGPHSKAFIVAMP 455
>gi|27894376 cell adhesion molecule with homology to L1CAM precursor
[Homo sapiens]
Length = 1224
Score = 63.5 bits (153), Expect = 1e-09
Identities = 101/453 (22%), Positives = 170/453 (37%), Gaps = 44/453 (9%)
Query: 400 LPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPG-- 457
L +Q IY +AH L + V + + P P + + + + +V+L+W
Sbjct: 599 LEDQGIY--CCSAHTALDSAADITQVTVLD--VPDPPENLHLSERQNRSVRLTWEAGADH 654
Query: 458 NFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFW 517
N ++ E E K + + ++G + + L L P+ Y FR+ E
Sbjct: 655 NSNISEYIVEFEGNKEEPGRWEELTRVQGKKTTVIL----PLAPFVRYQFRVIAVNEV-G 709
Query: 518 KWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSS 577
+ H T A+P + P R +S K +II W+PL E NG L Y V+
Sbjct: 710 RSQPSQPSDHHETPPAAPDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGPGLEYRVTWKP 769
Query: 578 DEETQSLSEIPDPQHKAEIRLDK--NDYIISVVAKNSVGSSPPSKIASM----EIPNDDL 631
E H + Y + V A N +GS P + ++ + P+
Sbjct: 770 QGAPVEWEEETVTNHTLRVMTPAVYAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAP 829
Query: 632 KIEQVVGMGKGIL-LTWHYDP-----NMTCDYVIKWCNS-----SRSEPCLMDWRKVPSN 680
I V + ++ +TW P Y I W + R+ P ++ +
Sbjct: 830 VIHGVDVINSTLVKVTWSTVPKDRVHGRLKGYQINWWKTKSLLDGRTHPKEVNILRFSGQ 889
Query: 681 STETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSI 740
++ S + Y + G + I E P V D+
Sbjct: 890 RNSGMVPSLDAFSEFHLTVLAYNSKGAGPE-SEPYIFQTPEGVPEQPTFLKVIKVDKDTA 948
Query: 741 LVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIAD 800
+ W +P ++L G L GYL + + DT ++ L +DI NIT S+ + +++
Sbjct: 949 TLSW-GLP-KKLNGNLTGYLLQY-QIINDTYEIGEL----NDI---NITTPSKPSWHLSN 998
Query: 801 LQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENS 833
L T Y LRA T G G +T+E+S
Sbjct: 999 LNATTKYKFYLRACTSQGCGKP-----ITEESS 1026
Score = 35.4 bits (80), Expect = 0.30
Identities = 34/124 (27%), Positives = 52/124 (41%), Gaps = 6/124 (4%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNE 391
P PQ + + KE+I W P + GP Y + G V + E TN
Sbjct: 727 PDRNPQNIRVQASQPKEMIIKWEPLKSMEQNGP-GLEYRVTWKPQGAPVEWEE-ETVTNH 784
Query: 392 SYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHT-PTSFKVKDINSTAV 449
+ +++ + Y+ + A N LG V + + + YP T P V INST V
Sbjct: 785 TLRVMTPAV--YAPYDVKVQAINQLGSGPDPQSVTLYSGEDYPDTAPVIHGVDVINSTLV 842
Query: 450 KLSW 453
K++W
Sbjct: 843 KVTW 846
>gi|4758062 cytokine receptor-like factor 1 [Homo sapiens]
Length = 422
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/310 (22%), Positives = 131/310 (42%), Gaps = 41/310 (13%)
Query: 254 VFPQDKVILVGSDITFCC--------VSQEKVLSALIGHTNCPLIH--LDGENVAIKIRN 303
+ PQD +L+GS + C + E + L G P + L+ +A+ + N
Sbjct: 43 ISPQDPTLLIGSSLLATCSVHGDPPGATAEGLYWTLNGRRLPPELSRVLNASTLALALAN 102
Query: 304 ISVSAS-SGTNVVFTTEDN--IFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTA 360
++ S SG N+V D + G+ ++ G PP+ P ++C + ++K++ C W PG
Sbjct: 103 LNGSRQRSGDNLVCHARDGSILAGSCLYVGLPPEKPVNISCWSKNMKDLTCRWTPG---- 158
Query: 361 LVGPRATSYTLVE-SFSGKYVRLKRAEAPTNESYQL-------LFQMLPNQEIYNFTLNA 412
A T + ++S KY + T E Y + + L Y + A
Sbjct: 159 -----AHGETFLHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEA 213
Query: 413 HNPLGRSQSTIL-VNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIK 471
N LG ++S +L ++I + V P V + +LS A +FL + + +
Sbjct: 214 TNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPALKDFLFQAKYQ 273
Query: 472 KSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCS------TETFWKWSKWSNK 525
V++ + + ++ L L P T+Y ++RC+ ++ WS+WS
Sbjct: 274 IRYRVEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRCNPFGIYGSKKAGIWSEWS-- 331
Query: 526 KQHLTTEASP 535
H T ++P
Sbjct: 332 --HPTAASTP 339
>gi|81158226 neuronal cell adhesion molecule isoform A precursor
[Homo sapiens]
Length = 1304
Score = 63.2 bits (152), Expect = 1e-09
Identities = 62/229 (27%), Positives = 95/229 (41%), Gaps = 17/229 (7%)
Query: 433 PHTPTSFKVKDINSTAVKLSWHLPG---NFAKINFLCEIEIKKSNSVQEQRNVTIKGVEN 489
P+ P ++ D +V+LSW PG N F+ E E + G +
Sbjct: 647 PNPPFDLELTDQLDKSVQLSW-TPGDDNNSPITKFIIEYEDAMHKPGLWHHQTEVSGTQT 705
Query: 490 SSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDG 549
++ L KL+PY Y+FR+ + + K +Q+LT + P K P S+
Sbjct: 706 TAQL----KLSPYVNYSFRVM-AVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLGSEP 760
Query: 550 KNLIIYWKPLPINEANGKILSYNVSC---SSDEETQSLSEIPDPQHKAEIRLDKNDYIIS 606
NL+I WKPL E+NG L Y VS D+E S+ ++ Y+I
Sbjct: 761 DNLVITWKPLNGFESNGPGLQYKVSWRQKDGDDEWTSVVVANVSKYIVSGTPTFVPYLIK 820
Query: 607 VVAKNSVGSSPPSKIASMEIPNDDLKI----EQVVGMGKGILLTWHYDP 651
V A N +G +P + M +DL + V + L H+DP
Sbjct: 821 VQALNDMGFAPEPAVV-MGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDP 868
Score = 51.6 bits (122), Expect = 4e-06
Identities = 59/252 (23%), Positives = 107/252 (42%), Gaps = 26/252 (10%)
Query: 585 SEIPDPQHKAEIRLDKN-DYIISVVAKNSVGSSPPSKIASMEIPN---DDLKIEQVVGMG 640
+E+ Q A+++L +Y V+A NS+G S PS+ + + D V G+G
Sbjct: 698 TEVSGTQTTAQLKLSPYVNYSFRVMAVNSIGKSLPSEASEQYLTKASEPDKNPTAVEGLG 757
Query: 641 K---GILLTWH----YDPNMT-CDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFR 692
+++TW ++ N Y + W + +W V + I S
Sbjct: 758 SEPDNLVITWKPLNGFESNGPGLQYKVSWRQKDGDD----EWTSVVVANVSKYIVSGT-P 812
Query: 693 PGIRYNFFLYGCRNQGYQLLRSMI-GYIEELAPIVAP-NFTVEDTSADSILVKWEDIPVE 750
+ Y + + G+ +++ G+ E P+VAP N V ++ V W+ +P++
Sbjct: 813 TFVPYLIKVQALNDMGFAPEPAVVMGHSGEDLPMVAPGNVRVNVVNSTLAEVHWDPVPLK 872
Query: 751 ELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTL-RIADLQGKTSYHL 809
+RG L+GY Y+ K + + + R I+ K +T KT + L+ + Y L
Sbjct: 873 SIRGHLQGYRIYYWKTQSSSKR------NRRHIEKKILTFQGSKTHGMLPGLEPFSHYTL 926
Query: 810 VLRAYTDGGVGP 821
+R G GP
Sbjct: 927 NVRVVNGKGEGP 938
Score = 36.2 bits (82), Expect = 0.17
Identities = 61/330 (18%), Positives = 129/330 (39%), Gaps = 39/330 (11%)
Query: 554 IYWKPLPINEANGKILSYNV----SCSSDE------ETQSLSEIPDPQHKAEIRLDK-ND 602
++W P+P+ G + Y + + SS + E + L+ H L+ +
Sbjct: 864 VHWDPVPLKSIRGHLQGYRIYYWKTQSSSKRNRRHIEKKILTFQGSKTHGMLPGLEPFSH 923
Query: 603 YIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGIL--LTWHYDP-----NMTC 655
Y ++V N G P S P + + L LT +DP +
Sbjct: 924 YTLNVRVVNGKGEGPASPDRVFNTPEGVPSAPSSLKIVNPTLDSLTLEWDPPSHPNGILT 983
Query: 656 DYVIKW--CNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLR 713
+Y +K+ NS+ L+D K+P+N T +++ F ++ F+ G Q+
Sbjct: 984 EYTLKYQPINSTHELGPLVDL-KIPANKTRWTLKNLNFSTRYKFYFYAQTSAGSGSQITE 1042
Query: 714 SMIGYIEE---LAP------IVAPNFTVEDTSADS----ILVKWEDIPVEELRGFLRGYL 760
+ ++E L P + A N + + +A + + WE E + Y+
Sbjct: 1043 EAVTTVDEAGILPPDVGAGKVQAVNPRISNLTAAAAETYANISWEYEGPEH----VNFYV 1098
Query: 761 FYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVG 820
Y G ++ + ++ RS +K + + +R+ + G + + + G
Sbjct: 1099 EYGVAGSKEEWRKEIVNGSRSFFGLKGLMPGTAYKVRVGAV-GDSGFVSSEDVFETGPAM 1157
Query: 821 PEKSMYVVTKENSVGLIIAILIPVAVAVIV 850
+ + + T+ +GL+ A+ + + + +IV
Sbjct: 1158 ASRQVDIATQGWFIGLMCAVALLILILLIV 1187
>gi|109633041 protein tyrosine phosphatase, receptor type, F isoform
1 precursor [Homo sapiens]
Length = 1907
Score = 62.8 bits (151), Expect = 2e-09
Identities = 95/446 (21%), Positives = 164/446 (36%), Gaps = 51/446 (11%)
Query: 407 NFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLC 466
N+T A + LG ++T +T K P P V + +T+V L+W GN + +
Sbjct: 295 NYTCVAISSLGMIEAT--AQVTVKALPKPPIDLVVTETTATSVTLTWD-SGNSEPVTYY- 350
Query: 467 EIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKK 526
I+ + E + GV + Y ++ L+P++ Y FR+ + + + S
Sbjct: 351 --GIQYRAAGTEGPFQEVDGVATTRY--SIGGLSPFSEYAFRV-LAVNSIGRGPP-SEAV 404
Query: 527 QHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE 586
+ T E +PS P + +++ W+P E NG + Y V + D
Sbjct: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPP--EEPNGLVRGYRVYYTPDSRRP---- 458
Query: 587 IPDPQHKAEIR----------LDKNDYIISVVAKNSVGSSPPSKIASME----IPNDDLK 632
P+ HK L Y + V+A +VG PPS ++ +P
Sbjct: 459 -PNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPAD 517
Query: 633 IEQVVGMGKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDE 690
+ V I L+W P + ++ W + KV + T + D
Sbjct: 518 FQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQ-----HKVTFDPTSSYTLED- 571
Query: 691 FRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADS--ILVKWEDIP 748
+P Y F L + G + I + AP V S S + V W P
Sbjct: 572 LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPP 631
Query: 749 VEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYH 808
+ G + Y + + + V++ + + + L+ T Y
Sbjct: 632 ADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE----------HSSWDLVGLEKWTEYR 681
Query: 809 LVLRAYTDGGVGPEKSMYVVTKENSV 834
+ +RA+TD G GPE S +V + V
Sbjct: 682 VWVRAHTDVGPGPESSPVLVRTDEDV 707
Score = 52.4 bits (124), Expect = 2e-06
Identities = 111/515 (21%), Positives = 186/515 (36%), Gaps = 60/515 (11%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNE 391
P PQ++ C + + SW P + G E+ G+ + + E
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 392 SYQLLFQMLPNQEIYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDINSTAV 449
L Y + AH +G S +LV E V P +V+ +NSTAV
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAV 725
Query: 450 KLSWHLP---GNFAKINFLCEIEIKKSNSVQEQRNVTI-----------KGVENSSYLVA 495
+ W LP +I ++ N E R + I + E+ Y
Sbjct: 726 HVYWKLPVPSKQHGQIRGYQVTYVRLENG--EPRGLPIIQDVMLAEAQWRPEESEDYETT 783
Query: 496 LDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIY 555
+ L P T Y+ + T + K + T G T ++ ++
Sbjct: 784 ISGLTPETTYSVTVAAYTTK----GDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQ 839
Query: 556 WKPLPINEANGKILSYNVS-CSSDEETQSLSEI-PDPQHKAEIRLDKND-YIISVVAKN- 611
W P E G++L Y + C +DE + + D QH L K YI + AKN
Sbjct: 840 WHPP--KELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNR 897
Query: 612 -SVGSSPPSKIASME-IPNDDLKIEQVVGMGKGIL-LTWHYDPNMTCDYVIKWCNSSRSE 668
+G +I + E +P+ + V G+ L W DP + + + + +
Sbjct: 898 AGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAW--DPPVLAERNGRIISYTVVF 955
Query: 669 PCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSMIGYIEELAPIVA 727
+ +++ + +T+T +P Y+ + ++G L S+ + + A
Sbjct: 956 RDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFA 1015
Query: 728 PNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKG-ERDTSKMRVLESGRSDIKVK 786
NF V S+L+ WE +P + + + + Y G+ E D MR L
Sbjct: 1016 KNFRVAAAMKTSVLLSWE-VP-DSYKSAVPFKILYNGQSVEVDGHSMRKL---------- 1063
Query: 787 NITDISQKTLRIADLQGKTSYHLVL--RAYTDGGV 819
IADLQ T Y VL R + GG+
Sbjct: 1064 -----------IADLQPNTEYSFVLMNRGSSAGGL 1087
Score = 52.0 bits (123), Expect = 3e-06
Identities = 115/500 (23%), Positives = 194/500 (38%), Gaps = 63/500 (12%)
Query: 388 PTNESYQLLFQMLPNQEIYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDIN 445
PT+ SY L + L +Y F L A + +G TI + P +
Sbjct: 563 PTS-SYTL--EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG 619
Query: 446 STAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNV-TIKGV--ENSSY-LVALDKLNP 501
ST V++SW P ++ + + + E R + G+ E+SS+ LV L+K
Sbjct: 620 STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTE 679
Query: 502 YTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWK-PLP 560
Y ++ +R T+ S+ T E PS P + + +YWK P+P
Sbjct: 680 YRVW---VRAHTDV--GPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVP 734
Query: 561 INEANGKILSYNVSCSSDE--ETQSLSEIPDPQ-HKAEIRLDKND--------------Y 603
++ +G+I Y V+ E E + L I D +A+ R ++++ Y
Sbjct: 735 -SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTY 793
Query: 604 IISVVAKNSVGSSPPSK----IASMEIPNDDLKIEQVVGMGKGILLTWHYD---PNMTCD 656
++V A + G SK + +P + M LL WH P
Sbjct: 794 SVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTA-LLQWHPPKELPGELLG 852
Query: 657 YVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSM 715
Y +++C + + P +D+ K + T T + G Y F L G +
Sbjct: 853 YRLQYCRADEARPNTIDFGKDDQHFTVTGLHK-----GTTYIFRLAAKNRAGLGEEFEKE 907
Query: 716 IGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRV 775
I E+L N V + + + W+ + E G + Y F RD + +
Sbjct: 908 IRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF----RDINSQQE 963
Query: 776 LESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVG 835
L+ NIT ++ TL L+ T+Y + +RA+T G GP S + ++ V
Sbjct: 964 LQ---------NITTDTRFTL--TGLKPDTTYDIKVRAWTSKGSGP-LSPSIQSRTMPVE 1011
Query: 836 LIIAILIPVAVAVIVGVVTS 855
+ A VA A+ V+ S
Sbjct: 1012 QVFAKNFRVAAAMKTSVLLS 1031
>gi|109633039 protein tyrosine phosphatase, receptor type, F isoform
2 precursor [Homo sapiens]
Length = 1898
Score = 62.8 bits (151), Expect = 2e-09
Identities = 95/446 (21%), Positives = 164/446 (36%), Gaps = 51/446 (11%)
Query: 407 NFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLC 466
N+T A + LG ++T +T K P P V + +T+V L+W GN + +
Sbjct: 295 NYTCVAISSLGMIEAT--AQVTVKALPKPPIDLVVTETTATSVTLTWD-SGNSEPVTYY- 350
Query: 467 EIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKK 526
I+ + E + GV + Y ++ L+P++ Y FR+ + + + S
Sbjct: 351 --GIQYRAAGTEGPFQEVDGVATTRY--SIGGLSPFSEYAFRV-LAVNSIGRGPP-SEAV 404
Query: 527 QHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE 586
+ T E +PS P + +++ W+P E NG + Y V + D
Sbjct: 405 RARTGEQAPSSPPRRVQARMLSASTMLVQWEPP--EEPNGLVRGYRVYYTPDSRRP---- 458
Query: 587 IPDPQHKAEIR----------LDKNDYIISVVAKNSVGSSPPSKIASME----IPNDDLK 632
P+ HK L Y + V+A +VG PPS ++ +P
Sbjct: 459 -PNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPAD 517
Query: 633 IEQVVGMGKGILLTWHYDPN--MTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDE 690
+ V I L+W P + ++ W + KV + T + D
Sbjct: 518 FQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQ-----HKVTFDPTSSYTLED- 571
Query: 691 FRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADS--ILVKWEDIP 748
+P Y F L + G + I + AP V S S + V W P
Sbjct: 572 LKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPP 631
Query: 749 VEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYH 808
+ G + Y + + + V++ + + + L+ T Y
Sbjct: 632 ADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE----------HSSWDLVGLEKWTEYR 681
Query: 809 LVLRAYTDGGVGPEKSMYVVTKENSV 834
+ +RA+TD G GPE S +V + V
Sbjct: 682 VWVRAHTDVGPGPESSPVLVRTDEDV 707
Score = 52.8 bits (125), Expect = 2e-06
Identities = 115/492 (23%), Positives = 190/492 (38%), Gaps = 56/492 (11%)
Query: 388 PTNESYQLLFQMLPNQEIYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDIN 445
PT+ SY L + L +Y F L A + +G TI + P +
Sbjct: 563 PTS-SYTL--EDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMG 619
Query: 446 STAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNV-TIKGV--ENSSY-LVALDKLNP 501
ST V++SW P ++ + + + E R + G+ E+SS+ LV L+K
Sbjct: 620 STTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTE 679
Query: 502 YTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWK-PLP 560
Y ++ +R T+ S+ T E PS P + + +YWK P+P
Sbjct: 680 YRVW---VRAHTDV--GPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVP 734
Query: 561 INEANGKILSYNVSCSSDE--ETQSLSEIPDPQHKAEIR-------LDKNDYIISVVAKN 611
++ +G+I Y V+ E E + L I D AE + + Y ++V A
Sbjct: 735 -SKQHGQIRGYQVTYVRLENGEPRGLPIIQDVM-LAEAQETTISGLTPETTYSVTVAAYT 792
Query: 612 SVGSSPPSK----IASMEIPNDDLKIEQVVGMGKGILLTWHYD---PNMTCDYVIKWCNS 664
+ G SK + +P + M LL WH P Y +++C +
Sbjct: 793 TKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTA-LLQWHPPKELPGELLGYRLQYCRA 851
Query: 665 SRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSMIGYIEELA 723
+ P +D+ K + T T + G Y F L G + I E+L
Sbjct: 852 DEARPNTIDFGKDDQHFTVTGLHK-----GTTYIFRLAAKNRAGLGEEFEKEIRTPEDLP 906
Query: 724 PIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDI 783
N V + + + W+ + E G + Y F RD + + L+
Sbjct: 907 SGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVF----RDINSQQELQ------ 956
Query: 784 KVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAILIP 843
NIT ++ TL L+ T+Y + +RA+T G GP S + ++ V + A
Sbjct: 957 ---NITTDTRFTL--TGLKPDTTYDIKVRAWTSKGSGP-LSPSIQSRTMPVEQVFAKNFR 1010
Query: 844 VAVAVIVGVVTS 855
VA A+ V+ S
Sbjct: 1011 VAAAMKTSVLLS 1022
Score = 49.7 bits (117), Expect = 2e-05
Identities = 106/504 (21%), Positives = 181/504 (35%), Gaps = 47/504 (9%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNE 391
P PQ++ C + + SW P + G E+ G+ + + E
Sbjct: 606 PSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISRE 665
Query: 392 SYQLLFQMLPNQEIYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDINSTAV 449
L Y + AH +G S +LV E V P +V+ +NSTAV
Sbjct: 666 HSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAV 725
Query: 450 KLSWHLP---GNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYT 506
+ W LP +I ++ N + + + + L P T Y+
Sbjct: 726 HVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQETTISGLTPETTYS 785
Query: 507 FRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANG 566
+ T + K + T G T ++ ++ W P E G
Sbjct: 786 VTVAAYTTK----GDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPP--KELPG 839
Query: 567 KILSYNVS-CSSDEETQSLSEI-PDPQHKAEIRLDKND-YIISVVAKN--SVGSSPPSKI 621
++L Y + C +DE + + D QH L K YI + AKN +G +I
Sbjct: 840 ELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEI 899
Query: 622 ASME-IPNDDLKIEQVVGMGKGIL-LTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPS 679
+ E +P+ + V G+ L W DP + + + + + + +++ +
Sbjct: 900 RTPEDLPSGFPQNLHVTGLTTSTTELAW--DPPVLAERNGRIISYTVVFRDINSQQELQN 957
Query: 680 NSTETVIESDEFRPGIRYNFFLYGCRNQGY-QLLRSMIGYIEELAPIVAPNFTVEDTSAD 738
+T+T +P Y+ + ++G L S+ + + A NF V
Sbjct: 958 ITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKT 1017
Query: 739 SILVKWEDIPVEELRGFLRGYLFYFGKG-ERDTSKMRVLESGRSDIKVKNITDISQKTLR 797
S+L+ WE +P + + + + Y G+ E D MR L
Sbjct: 1018 SVLLSWE-VP-DSYKSAVPFKILYNGQSVEVDGHSMRKL--------------------- 1054
Query: 798 IADLQGKTSYHLVL--RAYTDGGV 819
IADLQ T Y VL R + GG+
Sbjct: 1055 IADLQPNTEYSFVLMNRGSSAGGL 1078
>gi|24430212 interleukin 23 receptor precursor [Homo sapiens]
Length = 629
Score = 62.4 bits (150), Expect = 2e-09
Identities = 61/242 (25%), Positives = 98/242 (40%), Gaps = 38/242 (15%)
Query: 319 EDNIFGTVIFAGYPPDTPQQLNCETHDLK-EIICSWNPGRVTALVGPRATSYTLVESFSG 377
E I G I +GYPPD P ++ C ++ + C+WN G++T + T Y
Sbjct: 111 ETLICGKDISSGYPPDIPDEVTCVIYEYSGNMTCTWNAGKLTYI----DTKYV------- 159
Query: 378 KYVRLKRAEAPTNESY------QLLFQMLPNQEIYNFTLNAHNPLGRSQSTIL-VNITEK 430
V +K E + Y + L + Y + A N LG +S L +++ +
Sbjct: 160 --VHVKSLETEEEQQYLTSSYINISTDSLQGGKKYLVWVQAANALGMEESKQLQIHLDDI 217
Query: 431 VYPHTPTSFKVKDINSTAVK--LSWHLPGNFAKINFLCEIEIKKSNSVQ---EQRNVTIK 485
V P + + IN+T K + W K++ CE+ K + + ++ +
Sbjct: 218 VIPSAAVISRAETINATVPKTIIYWDSQTTIEKVS--CEMRYKATTNQTWNVKEFDTNFT 275
Query: 486 GVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASP---SKG--PD 540
V+ S + L P Y F++RC W WS+ H T E P SK D
Sbjct: 276 YVQQSEFY-----LEPNIKYVFQVRCQETGKRYWQPWSSLFFHKTPETVPQVTSKAFQHD 330
Query: 541 TW 542
TW
Sbjct: 331 TW 332
>gi|104487002 protein tyrosine phosphatase, receptor type, D isoform
5 precursor [Homo sapiens]
Length = 1502
Score = 58.5 bits (140), Expect = 3e-08
Identities = 87/350 (24%), Positives = 142/350 (40%), Gaps = 31/350 (8%)
Query: 407 NFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLC 466
N+T A + LG ++ + IT K P P + V + +T++ L+W GN +++
Sbjct: 296 NYTCVAMSTLGVIEA--IAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPVSYYI 352
Query: 467 EIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKK 526
I+ K NS E+ I GV + Y VA L+PY+ Y FR+ + + S
Sbjct: 353 -IQHKPKNS--EELYKEIDGVATTRYSVA--GLSPYSDYEFRV-VAVNNIGRGPP-SEPV 405
Query: 527 QHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE 586
T+E +PS P + +++ WK E NG+I Y V + D TQ ++
Sbjct: 406 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP--EEPNGQIQGYRVYYTMDP-TQHVNN 462
Query: 587 -----IPDPQHKAEIRL-DKNDYIISVVAKNSVGSSPPSK----IASMEIPNDDLKIEQV 636
+ D Q L + Y + V+A S+G P S I +P L +
Sbjct: 463 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAE 522
Query: 637 VGMGKGILLTWHYDPNMT-CDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGI 695
ILL+W + T +Y + + + E + R T ++ +P
Sbjct: 523 PESETSILLSWTPPRSDTIANYELVYKDGEHGE----EQRITIEPGTSYRLQG--LKPNS 576
Query: 696 RYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWE 745
Y F L QG + I + + A NF V+ S+L+ WE
Sbjct: 577 LYYFRLAARSPQGLGASTAEIS-ARTMQSMFAKNFHVKAVMKTSVLLSWE 625
Score = 45.4 bits (106), Expect = 3e-04
Identities = 36/127 (28%), Positives = 53/127 (41%), Gaps = 9/127 (7%)
Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES 392
P P E I+ SW P R + +Y LV G++ +R S
Sbjct: 513 PGQPLNFKAEPESETSILLSWTPPRSDTIA-----NYELVYK-DGEHGEEQRITIEPGTS 566
Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLS 452
Y+L Q L +Y F L A +P G ST ++ + +F VK + T+V LS
Sbjct: 567 YRL--QGLKPNSLYYFRLAARSPQGLGASTAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 623
Query: 453 WHLPGNF 459
W +P N+
Sbjct: 624 WEIPENY 630
Score = 37.4 bits (85), Expect = 0.078
Identities = 33/108 (30%), Positives = 54/108 (50%), Gaps = 8/108 (7%)
Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
Q+ Y+ + A +G S+ + IT+ P P +FK + + T++ LSW P +
Sbjct: 482 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 541
Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRI 509
N+ E+ K +EQR +TI+ +SY L L P +LY FR+
Sbjct: 542 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRL 582
>gi|18860894 protein tyrosine phosphatase, receptor type, D isoform
4 precursor [Homo sapiens]
Length = 1501
Score = 58.5 bits (140), Expect = 3e-08
Identities = 87/350 (24%), Positives = 142/350 (40%), Gaps = 31/350 (8%)
Query: 407 NFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLC 466
N+T A + LG ++ + IT K P P + V + +T++ L+W GN +++
Sbjct: 299 NYTCVAMSTLGVIEA--IAQITVKALPKPPGTPVVTESTATSITLTWD-SGNPEPVSYYI 355
Query: 467 EIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKK 526
I+ K NS E+ I GV + Y VA L+PY+ Y FR+ + + S
Sbjct: 356 -IQHKPKNS--EELYKEIDGVATTRYSVA--GLSPYSDYEFRV-VAVNNIGRGPP-SEPV 408
Query: 527 QHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSE 586
T+E +PS P + +++ WK E NG+I Y V + D TQ ++
Sbjct: 409 LTQTSEQAPSSAPRDVQARMLSSTTILVQWKEP--EEPNGQIQGYRVYYTMDP-TQHVNN 465
Query: 587 -----IPDPQHKAEIRL-DKNDYIISVVAKNSVGSSPPSK----IASMEIPNDDLKIEQV 636
+ D Q L + Y + V+A S+G P S I +P L +
Sbjct: 466 WMKHNVADSQITTIGNLVPQKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAE 525
Query: 637 VGMGKGILLTWHYDPNMT-CDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGI 695
ILL+W + T +Y + + + E + R T ++ +P
Sbjct: 526 PESETSILLSWTPPRSDTIANYELVYKDGEHGE----EQRITIEPGTSYRLQG--LKPNS 579
Query: 696 RYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWE 745
Y F L QG + I + + A NF V+ S+L+ WE
Sbjct: 580 LYYFRLAARSPQGLGASTAEIS-ARTMQSMFAKNFHVKAVMKTSVLLSWE 628
Score = 45.4 bits (106), Expect = 3e-04
Identities = 36/127 (28%), Positives = 53/127 (41%), Gaps = 9/127 (7%)
Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES 392
P P E I+ SW P R + +Y LV G++ +R S
Sbjct: 516 PGQPLNFKAEPESETSILLSWTPPRSDTIA-----NYELVYK-DGEHGEEQRITIEPGTS 569
Query: 393 YQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLS 452
Y+L Q L +Y F L A +P G ST ++ + +F VK + T+V LS
Sbjct: 570 YRL--QGLKPNSLYYFRLAARSPQGLGASTAEIS-ARTMQSMFAKNFHVKAVMKTSVLLS 626
Query: 453 WHLPGNF 459
W +P N+
Sbjct: 627 WEIPENY 633
Score = 37.4 bits (85), Expect = 0.078
Identities = 33/108 (30%), Positives = 54/108 (50%), Gaps = 8/108 (7%)
Query: 403 QEIYNFTLNAHNPLGRSQ-STILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAK 461
Q+ Y+ + A +G S+ + IT+ P P +FK + + T++ LSW P +
Sbjct: 485 QKTYSVKVLAFTSIGDGPLSSDIQVITQTGVPGQPLNFKAEPESETSILLSWTPPRSDTI 544
Query: 462 INFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRI 509
N+ E+ K +EQR +TI+ +SY L L P +LY FR+
Sbjct: 545 ANY--ELVYKDGEHGEEQR-ITIE--PGTSY--RLQGLKPNSLYYFRL 585
>gi|75709184 contactin 3 [Homo sapiens]
Length = 1028
Score = 58.2 bits (139), Expect = 4e-08
Identities = 85/427 (19%), Positives = 157/427 (36%), Gaps = 52/427 (12%)
Query: 433 PHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGV-ENSS 491
P P + KV +I T +LSW + I+ + SV Q T+ V + +
Sbjct: 598 PGPPENVKVDEITDTTAQLSWKEGKDNHSPVISYSIQARTPFSVGWQTVTTVPEVIDGKT 657
Query: 492 YLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKN 551
+ + +LNP+ Y FR+ S + ++K T EA P P
Sbjct: 658 HTATVVELNPWVEYEFRVVASNKIGGGEPSLPSEKVR-TEEAVPEVPPSEVNGGGGSRSE 716
Query: 552 LIIYWKPLPINEANGKILSYNVSCSSDEET---QSLSEIPD-PQH--KAEIRLDKNDYII 605
L+I W P+P NG+ Y V+ T Q++ PD P++ + E + + Y +
Sbjct: 717 LVITWDPVPEELQNGEGFGYVVAFRPLGVTTWIQTVVTSPDTPRYVFRNESIVPYSPYEV 776
Query: 606 SVVAKNSVGSSP-----------------PSKIASMEIPNDDLKIEQVVGMGKGILLTWH 648
V N+ G P PS++++ + + ++++ + W
Sbjct: 777 KVGVYNNKGEGPFSPVTTVFSAEEEPTVAPSQVSANSLSSSEIEVSWNT-------IPWK 829
Query: 649 YDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQG 708
Y +++ N E KV N T + + + Y + + G
Sbjct: 830 LSNGHLLGYEVRYWNGGGKEES-SSKMKVAGNETSARLRG--LKSNLAYYTAVRAYNSAG 886
Query: 709 YQLLRSMIGYIEELAPIVAPNFTVEDTSADS-ILVKWEDIPVEELRGFLRGYLFYFGKGE 767
+ + + P P V + D+ +L+ WE + E + GY ++
Sbjct: 887 AGPFSATVNVTTKKTPPSQPPGNVVWNATDTKVLLNWEQVKAMENESEVTGYKVFY---- 942
Query: 768 RDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYV 827
S +++++V N + KT L K Y + ++A TDGG G
Sbjct: 943 --------RTSSQNNVQVLN----TNKTSAELVLPIKEDYIIEVKATTDGGDGTSSEQIR 990
Query: 828 VTKENSV 834
+ + S+
Sbjct: 991 IPRITSM 997
Score = 32.0 bits (71), Expect = 3.3
Identities = 27/109 (24%), Positives = 49/109 (44%), Gaps = 7/109 (6%)
Query: 952 PIIEEEIPNPAADEAGGTAQVIYIDVQSMYQPQAKPEEEQENDPVGGAGYKPQMHLPINS 1011
P +E E A+++ GG + + + +A PE ++ GG G + ++ + +
Sbjct: 667 PWVEYEFRVVASNKIGGGEPSL--PSEKVRTEEAVPEVPP-SEVNGGGGSRSELVITWDP 723
Query: 1012 TVEDIAAEEDLDKTAGYRPQANVNTWN---LVSPDSPRSIDSNSEIVSF 1057
E++ E +RP V TW + SPD+PR + N IV +
Sbjct: 724 VPEELQNGEGFGYVVAFRP-LGVTTWIQTVVTSPDTPRYVFRNESIVPY 771
>gi|222537743 protein tyrosine phosphatase, receptor type, Q [Homo
sapiens]
Length = 2299
Score = 57.8 bits (138), Expect = 6e-08
Identities = 103/464 (22%), Positives = 175/464 (37%), Gaps = 79/464 (17%)
Query: 333 PDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNES 392
P + + +N + I+ W+P + T YT+ E TN +
Sbjct: 569 PSSIKIINYKNISSSSILLYWDPPEYP---NGKITHYTIYAM-----------ELDTNRA 614
Query: 393 YQL-------LFQMLPNQEIYNFTLNAHNPLGRS----QSTILVNITEKVYPHTPTSFKV 441
+Q+ L L Y + A +G S ++ I V +E +P +V
Sbjct: 615 FQITTIDNSFLITGLKKYTKYKMRVAASTHVGESSLSEENDIFVRTSEDEPESSPQDVEV 674
Query: 442 KDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNP 501
D+ + ++L W P I E+ K +++ + T + L L P
Sbjct: 675 IDVTADEIRLKWSPPEKPNGIIIAYEVLYKNIDTLYMKNTSTTD--------IILRNLRP 726
Query: 502 YTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPD--TWREWSSDGKNLIIYWKPL 559
+TLY +R T F ++ S+ T+E P P+ T++ SS L L
Sbjct: 727 HTLYNISVRSYTR-FGHGNQVSSLLSVRTSETVPDSAPENITYKNISSGEIELSF----L 781
Query: 560 PINEANGKILSYNV----SCSSDEETQSLSEIPDPQHKAEIRLDKNDYIISVVAK----N 611
P + NG I Y + S ++E T + + + ++ YII V A
Sbjct: 782 PPSSPNGIIQKYTIYLKRSNGNEERTINTTSL---TQNIKVLKKYTQYIIEVSASTLKGE 838
Query: 612 SVGSSPPSKIASMEIPN---DDLKIEQVVGMGKGILLTWH--YDPNMTCDY--VIKWCNS 664
V S+P S + + P+ D ++Q+ G+ + L+W +PN Y V W S
Sbjct: 839 GVRSAPISILTEEDAPDSPPQDFSVKQLSGV--TVKLSWQPPLEPNGIILYYTVYVWNRS 896
Query: 665 SRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAP 724
S N TET +E + + Y+ ++ G RS I I P
Sbjct: 897 SLK----------TINVTETSLELSDLDYNVEYSAYVTASTRFGDGKTRSNI--ISFQTP 944
Query: 725 IVAPNFTVEDT-----SADSILVKWEDIPVEELRGFLRGYLFYF 763
AP+ +D S+ SI++ W P + G ++ Y Y+
Sbjct: 945 EGAPSDPPKDVYYANLSSSSIILFW--TPPSKPNGIIQYYSVYY 986
Score = 56.6 bits (135), Expect = 1e-07
Identities = 141/660 (21%), Positives = 248/660 (37%), Gaps = 120/660 (18%)
Query: 223 YIDNLHFSGLEEWSDWSPVKNISWIPDSQTKVFPQDKVILVGSDITFCCVSQEKVLSALI 282
++ NL + + S N+SW+P +Q + + F VS +L
Sbjct: 1056 FVGNLTYESIS-----STAINVSWVPPAQP------------NGLVFYYVSL--ILQQTP 1096
Query: 283 GHTNCPL------IHLDG-ENVAIKIRNISVSASSGTNVVFT------TEDNIFGTVIFA 329
H PL I+ D E I I+ S G + +T TE+++
Sbjct: 1097 RHVRPPLVTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDV------- 1149
Query: 330 GYPPDTPQQLNC-ETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAP 388
P+T +N + ++ SW+P V P + + G +
Sbjct: 1150 ---PETSPIINTFKNLSSTSVLLSWDPP-----VKPNGAIISYDLTLQGPN---ENYSFI 1198
Query: 389 TNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPHTPT-SFKVKDINST 447
T+++Y +L ++ P +Y+F A G S+IL T++ P P + + + S
Sbjct: 1199 TSDNYIILEELSPFT-LYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSD 1257
Query: 448 AVKLSWH---LPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTL 504
V L W LPG K+ + +I +++++ + I G + + LV L+ P +
Sbjct: 1258 FVWLKWSPSPLPGGIVKV-YSFKIHEHETDTIYYKN---ISGFKTEAKLVGLE---PVST 1310
Query: 505 YTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEA 564
Y+ R+ T+ +++SN + T E+ P + ++ +++++ W P +A
Sbjct: 1311 YSIRVSAFTKV-GNGNQFSNVVKFTTQESVPDV-VQNMQCMATSWQSVLVKWDPP--KKA 1366
Query: 565 NGKILSYNVSCSSDEETQSLSEIPDPQHKAEIRLDKN-DYIISVVAKNSVGSSPPSKIAS 623
NG I Y V+ E S P I+L N Y+ V A S G S
Sbjct: 1367 NGIITQYMVTV----ERNSTKVSPQDHMYTFIKLLANTSYVFKVRASTSAGEGDESTCHV 1422
Query: 624 MEIPNDDLKIEQVVGMGK----GILLTW---------HYDPNMTCDYVIKWCNSSRSEPC 670
+P + + LTW + +T + C SE C
Sbjct: 1423 STLPETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEEC 1482
Query: 671 LMDWRKVP-----SNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPI 725
+ +++K+ + ETV +FR Y F + N GY + I P
Sbjct: 1483 V-EYQKIQYLYEAHLTEETVYGLKKFR---WYRFQVAASTNAGYGNASNWISTKTLPGPP 1538
Query: 726 VAP--NFTVEDTSADSILVKWEDIPVEELRGFLRG---YLFYFGKGERDTSKMRVLESGR 780
P N V TS SI + W + V + G YL + D + ++S
Sbjct: 1539 DGPPENVHVVATSPFSISISWSEPAV------ITGPTCYLIDVKSVDNDEFNISFIKSNE 1592
Query: 781 SDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENSVGLIIAI 840
+ KT+ I DL+ T Y +V+ A+T G + YV K ++ ++ +
Sbjct: 1593 EN-----------KTIEIKDLEIFTRYSVVITAFT----GNISAAYVEGKSSAEMIVTTL 1637
Score = 52.8 bits (125), Expect = 2e-06
Identities = 118/544 (21%), Positives = 193/544 (35%), Gaps = 75/544 (13%)
Query: 318 TEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWN-PGRVTALVGPRATSYTLVESFS 376
T NI G P D P+ + II W P + ++ + Y + S
Sbjct: 934 TRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYY---RNTS 990
Query: 377 GKYVRLKRAEAPTNE----SYQLLFQMLPNQEIYNFTLNAHNPLG---RSQSTILVNITE 429
G +++ TN+ + + L Y F L A +G +S I V +
Sbjct: 991 GTFMQNFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTASTSVGNGNKSSDIIEVYTDQ 1050
Query: 430 KVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNV--TIKGV 487
+ + + I+STA+ +SW P + F I + Q R+V +
Sbjct: 1051 DIPEGFVGNLTYESISSTAINVSWVPPAQPNGLVFYYVSLILQ----QTPRHVRPPLVTY 1106
Query: 488 ENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGP--DTWREW 545
E S Y D L YT Y +I STE + ++ + T E P P +T++
Sbjct: 1107 ERSIY---FDNLEKYTDYILKITPSTEKGFS-DTYTAQLYIKTEEDVPETSPIINTFKNL 1162
Query: 546 SSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQS------------LSEIPDPQHK 593
SS ++++ W P P+ + NG I+SY+++ E S LS
Sbjct: 1163 SS--TSVLLSWDP-PV-KPNGAIISYDLTLQGPNENYSFITSDNYIILEELSPFTLYSFF 1218
Query: 594 AEIRLDKN---DYIISVVAKNSVGSSPPSKIASMEIPNDDLKIEQVVGMGKGILLTWHYD 650
A R K I+ SV +PP + + +D + L W
Sbjct: 1219 AAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSD------------FVWLKWSPS 1266
Query: 651 PNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQ 710
P + E + ++ + TE + E + G Q
Sbjct: 1267 PLPGGIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVSAFTKVGNGNQ 1326
Query: 711 LLRSMIGYIEELAPIVAPNFTVEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDT 770
+ +E P V N TS S+LVKW+ P ++ G + Y+ ER++
Sbjct: 1327 FSNVVKFTTQESVPDVVQNMQCMATSWQSVLVKWD--PPKKANGIITQYMVTV---ERNS 1381
Query: 771 SKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTK 830
+K+ + + IK L TSY +RA T G G E + +V T
Sbjct: 1382 TKVSPQDHMYTFIK----------------LLANTSYVFKVRASTSAGEGDESTCHVSTL 1425
Query: 831 ENSV 834
+V
Sbjct: 1426 PETV 1429
Score = 48.1 bits (113), Expect = 4e-05
Identities = 85/406 (20%), Positives = 165/406 (40%), Gaps = 44/406 (10%)
Query: 417 GRSQSTILVNITEKVYPHTPTS-FKVKDINSTAVKLSWHLPGNFAKINFLCEIEIKKSNS 475
G+++S I+ T + P P +++S+++ L W P I + + ++
Sbjct: 932 GKTRSNIISFQTPEGAPSDPPKDVYYANLSSSSIILFWTPPSKPNGIIQYYSVYYRNTSG 991
Query: 476 VQEQRNVTIKGV----ENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTT 531
Q N T+ V +N + +DKL ++ YTF + ST + +K S+ + T
Sbjct: 992 TFMQ-NFTLHEVTNDFDNMTVSTIIDKLTIFSYYTFWLTAST-SVGNGNKSSDIIEVYTD 1049
Query: 532 EASPS--KGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPD 589
+ P G T+ SS N + W +P + NG ++ Y VS ++T P
Sbjct: 1050 QDIPEGFVGNLTYESISSTAIN--VSW--VPPAQPNG-LVFYYVSLIL-QQTPRHVRPPL 1103
Query: 590 PQHKAEIRLDK----NDYIISVVAKNSVGSSPPSKI-----ASMEIPNDDLKIEQVVGMG 640
++ I D DYI+ + G S ++P I +
Sbjct: 1104 VTYERSIYFDNLEKYTDYILKITPSTEKGFSDTYTAQLYIKTEEDVPETSPIINTFKNLS 1163
Query: 641 K-GILLTWH--YDPN---MTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIESDEFRPG 694
+LL+W PN ++ D ++ N + S +++ I +E P
Sbjct: 1164 STSVLLSWDPPVKPNGAIISYDLTLQGPNENYS-----------FITSDNYIILEELSPF 1212
Query: 695 IRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAP-NFTVEDTSADSILVKWEDIPVEELR 753
Y+FF +G + Y +E P+ P N T+ + ++D + +KW P+
Sbjct: 1213 TLYSFFAAARTRKGLGPSSILFFYTDESVPLAPPQNLTLINCTSDFVWLKWSPSPLP--G 1270
Query: 754 GFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIA 799
G ++ Y F + E DT + + +++ K+ + +S ++R++
Sbjct: 1271 GIVKVYSFKIHEHETDTIYYKNISGFKTEAKLVGLEPVSTYSIRVS 1316
Score = 45.8 bits (107), Expect = 2e-04
Identities = 73/359 (20%), Positives = 134/359 (37%), Gaps = 61/359 (16%)
Query: 312 TNVV-FTTEDNIFGTVIFAGYPPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYT 370
+NVV FTT++++ PD Q + C + ++ W+P + + T Y
Sbjct: 1328 SNVVKFTTQESV----------PDVVQNMQCMATSWQSVLVKWDPPKKANGI---ITQYM 1374
Query: 371 L-VESFSGKYVRLKRAEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRS-QSTILVNIT 428
+ VE S K +P + Y + ++L N Y F + A G +ST V+
Sbjct: 1375 VTVERNSTKV-------SPQDHMYTFI-KLLANTS-YVFKVRASTSAGEGDESTCHVSTL 1425
Query: 429 EKVYPHTPTSFKVKDINSTAVKLSWHLP----GNFAKINFLCEIEIKKSNSVQEQRNVTI 484
+ P PT+ D+ ST+ L+W P G F ++ +K + + V
Sbjct: 1426 PETVPSVPTNIAFSDVQSTSATLTWIRPDTILGYFQNYKITTQLRAQKCKEWESEECVEY 1485
Query: 485 KGVE--NSSYLV--ALDKLNPYTLYTFRIRCSTET-FWKWSKWSNKKQHLTTEASPSKGP 539
+ ++ ++L + L + Y F++ ST + S W + K T P P
Sbjct: 1486 QKIQYLYEAHLTEETVYGLKKFRWYRFQVAASTNAGYGNASNWISTK---TLPGPPDGPP 1542
Query: 540 DTWREWSSDGKNLIIYW-KPLPINEANGKIL--------SYNVSCSSDEETQSLSEIPDP 590
+ ++ ++ I W +P I ++ +N+S E EI D
Sbjct: 1543 ENVHVVATSPFSISISWSEPAVITGPTCYLIDVKSVDNDEFNISFIKSNEENKTIEIKDL 1602
Query: 591 Q---------------HKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPNDDLKIE 634
+ A K+ + V S PP+ + +IP++ K +
Sbjct: 1603 EIFTRYSVVITAFTGNISAAYVEGKSSAEMIVTTLESAPKDPPNNMTFQKIPDEVTKFQ 1661
Score = 39.3 bits (90), Expect = 0.021
Identities = 86/438 (19%), Positives = 159/438 (36%), Gaps = 68/438 (15%)
Query: 409 TLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSW---HLPGNFAKINFL 465
+++A +G T+L T + P + K+I+S+++ L W P +
Sbjct: 545 SVSAFTIMGEGPPTVLSVRTRQQVPSSIKIINYKNISSSSILLYWDPPEYPNGKITHYTI 604
Query: 466 CEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNK 525
+E+ + + Q I ++NS + L K YT Y R+ ST N
Sbjct: 605 YAMELDTNRAFQ------ITTIDNSFLITGLKK---YTKYKMRVAASTHVGESSLSEEND 655
Query: 526 KQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDE----ET 581
T+E P P + + W P + NG I++Y V + + +
Sbjct: 656 IFVRTSEDEPESSPQDVEVIDVTADEIRLKWS--PPEKPNGIIIAYEVLYKNIDTLYMKN 713
Query: 582 QSLSEI------PDPQHKAEIRL-------DKNDYIISVVAKNSVGSSPPSKIASMEIPN 628
S ++I P + +R ++ ++SV +V S P I I +
Sbjct: 714 TSTTDIILRNLRPHTLYNISVRSYTRFGHGNQVSSLLSVRTSETVPDSAPENITYKNISS 773
Query: 629 DDLKIEQVVGMGKGILLTWHYDPNMTCDYVIKWCNSSRSEPCLMDWRKVPSNSTETVIES 688
++++ + ++ Y I S+ +E + N+T
Sbjct: 774 GEIELSFLPPSSPNGIIQ---------KYTIYLKRSNGNEERTI-------NTTSLTQNI 817
Query: 689 DEFRPGIRYNFFLYGCRNQGYQLLRSMIGYI-EELAPIVAP-NFTVEDTSADSILVKWED 746
+ +Y + +G + + I + EE AP P +F+V+ S ++ + W+
Sbjct: 818 KVLKKYTQYIIEVSASTLKGEGVRSAPISILTEEDAPDSPPQDFSVKQLSGVTVKLSWQ- 876
Query: 747 IPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQGKTS 806
P E G + Y Y RS +K N+T+ S L ++DL
Sbjct: 877 -PPLEPNGIILYYTVYVW--------------NRSSLKTINVTETS---LELSDLDYNVE 918
Query: 807 YHLVLRAYTDGGVGPEKS 824
Y + A T G G +S
Sbjct: 919 YSAYVTASTRFGDGKTRS 936
Score = 34.3 bits (77), Expect = 0.66
Identities = 42/169 (24%), Positives = 69/169 (40%), Gaps = 7/169 (4%)
Query: 406 YNFTLNAHNPLGRSQSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLPGNFAKINFL 465
Y+ T+++ + S T +V T P P + + S + LSW+ P N +
Sbjct: 30 YDITISSISTTYTSPVTRIVT-TNVTKPGPPVFLAGERVGSAGILLSWNTPPN-PNGRII 87
Query: 466 CEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNK 525
I K Q T + S V L LNP T T+ I+ + E +S+
Sbjct: 88 SYIVKYKEVCPWMQTVYTQVRSKPDSLEVLLTNLNPGT--TYEIKVAAENSAGIGVFSDP 145
Query: 526 KQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVS 574
T E++P K + E + +I++ P + NGKI S+ +S
Sbjct: 146 FLFQTAESAPGKVVNLTVEAYNASAVKLIWYLP---RQPNGKITSFKIS 191
Score = 32.0 bits (71), Expect = 3.3
Identities = 37/156 (23%), Positives = 58/156 (37%), Gaps = 9/156 (5%)
Query: 473 SNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTE 532
S+S Q ++ E S++V L PYT Y F + +T + + + T E
Sbjct: 249 SSSTLTQNEISSVWKEPISFVVT--HLRPYTTYLFEVSAATTE----AGYIDSTIVRTPE 302
Query: 533 ASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSDEETQSLSEIPDPQH 592
+ P P + GK+ I W P I GK SY V + D +
Sbjct: 303 SVPEGPPQNCVTGNITGKSFSILWDPPTI--VTGK-FSYRVELYGPSGRILDNSTKDLKF 359
Query: 593 KAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEIPN 628
Y + + A+ S G+ P S I+ P+
Sbjct: 360 AFTNLTPFTMYDVYIAAETSAGTGPKSNISVFTPPD 395
>gi|104487006 protein tyrosine phosphatase, receptor type, sigma
isoform 1 precursor [Homo sapiens]
Length = 1948
Score = 55.5 bits (132), Expect = 3e-07
Identities = 94/462 (20%), Positives = 173/462 (37%), Gaps = 53/462 (11%)
Query: 400 LPNQEIYNFTLNAHNPLGRSQSTILVNI-TEKVYPHTPTSFKVKDINSTAVKLSWHLPGN 458
L E Y + A +G + + + T++ P P + + + + T++ LSW P
Sbjct: 491 LLEDETYTVRVLAFTSVGDGPLSDPIQVKTQQGVPGQPMNLRAEARSETSITLSWSPPRQ 550
Query: 459 FAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWK 518
+ I + E+ ++ + R V +SY+V + L P T Y FR+ +
Sbjct: 551 ESIIKY--ELLFREGD---HGREVGRTFDPTTSYVV--EDLKPNTEYAFRLAARSPQ--G 601
Query: 519 WSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSC--- 575
++ + T ++ PS P + S +++ W+P P NG ++ Y+V
Sbjct: 602 LGAFTPVVRQRTLQSKPSAPPQDVKCVSVRSTAILVSWRPPPPETHNGALVGYSVRYRPL 661
Query: 576 -SSDEETQSLSEIPDPQHKAEIR-LDK-NDYIISVVAKNSVGSSPPSKIASMEIPND--- 629
S D E + ++ IP + + L+K Y I+ VA VG P S + D
Sbjct: 662 GSEDPEPKEVNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPS 721
Query: 630 --DLKIEQVVGMGKGILLTWHYDP---------NMTCDYVIKWCNSSRSEPCLMD----- 673
K+E I + W YV +R P + D
Sbjct: 722 APPRKVEAEALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLAD 781
Query: 674 --WRKVPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFT 731
W + E VI + + Y + G + ++ + + A + P +
Sbjct: 782 AQWETDDTAEYEMVITNLQPETAYSITVAAYTMKGDGARSKPKVV--VTKGAVLGRPTLS 839
Query: 732 VEDTSADSILVKWEDIPVEELRGFLRGYLFYFGKGERDTSKMRVLESGRSDIKVKNITDI 791
V+ T S+L +WE P + GY FG+ D++ + LE S+ +
Sbjct: 840 VQQTPEGSLLARWEP-PAGTAEDQVLGYRLQFGR--EDSTPLATLEFPPSEDR------- 889
Query: 792 SQKTLRIADLQGKTSYHLVLRAYTDGGVGPEKSMYVVTKENS 833
+ + +Y L A + GG+G E + + E++
Sbjct: 890 ----YTASGVHKGATYVFRLAARSRGGLGEEAAEVLSIPEDT 927
Score = 51.2 bits (121), Expect = 5e-06
Identities = 88/450 (19%), Positives = 160/450 (35%), Gaps = 48/450 (10%)
Query: 332 PPDTPQQLNCETHDLKEIICSWNPGRVTALVGPRATSYTLVESFSGKYVRLKRAEAPTNE 391
P PQ + C + I+ SW P P T + +S +Y L + E
Sbjct: 618 PSAPPQDVKCVSVRSTAILVSWRP-------PPPETHNGALVGYSVRYRPLGSEDPEPKE 670
Query: 392 -------SYQLLFQMLPNQEIYNFTLNAHNPL--GRSQSTILVNITEKVYPHTPTSFKVK 442
+ Q+L + L Y T AH + G S ++V E V P + +
Sbjct: 671 VNGIPPTTTQILLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAE 730
Query: 443 DINSTAVKLSWHLPGNFAKINFL--CEIEIKKSNSVQEQRNVTIKGV----------ENS 490
+N+TA+++ W P + + ++ + + + IK V + +
Sbjct: 731 ALNATAIRVLWRSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWETDDTA 790
Query: 491 SYLVALDKLNPYTLYTFRIRCSTETFWKWSKWSNKKQHLTTEASPSKGPDTWREWSSDGK 550
Y + + L P T Y+ + T K +K + + T+ + P + + +G
Sbjct: 791 EYEMVITNLQPETAYSITVAAYT---MKGDGARSKPKVVVTKGAVLGRPTLSVQQTPEG- 846
Query: 551 NLIIYWKPLPINEANGKILSYNVSCSSDEET--QSLSEIPDPQHKAEIRLDKNDYIISVV 608
+L+ W+P P A ++L Y + ++ T +L P + K + +
Sbjct: 847 SLLARWEP-PAGTAEDQVLGYRLQFGREDSTPLATLEFPPSEDRYTASGVHKGATYVFRL 905
Query: 609 AKNSVGSSPPSKIASMEIPNDDLK----IEQVVGMGKG--ILLTWHYD-PNMTCDYVIKW 661
A S G + IP D + I + G +LL W P ++K+
Sbjct: 906 AARSRGGLGEEAAEVLSIPEDTPRGHPQILEAAGNASAGTVLLRWLPPVPAERNGAIVKY 965
Query: 662 CNSSRSEPCLMDWRK-----VPSNSTETVIESDEFRPGIRYNFFLYGCRNQGYQLLRSMI 716
+ R L R+ E + +P Y+ + +G +
Sbjct: 966 TVAVREAGALGPARETELPAAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPV 1025
Query: 717 GYIEELAPIVAP-NFTVEDTSADSILVKWE 745
Y L V+P NF V+ S+L+ WE
Sbjct: 1026 RYRTFLRDQVSPKNFKVKMIMKTSVLLSWE 1055
Score = 45.8 bits (107), Expect = 2e-04
Identities = 98/512 (19%), Positives = 191/512 (37%), Gaps = 53/512 (10%)
Query: 349 IICSWNPGRVTALVGPRATSYTLVE----SFSGKYVRLKRAEAPTNESYQLLFQMLPNQE 404
I +W+ G P SY ++E S G Y ++K T S + + PN E
Sbjct: 348 ITITWDSGN------PDPVSYYVIEYKSKSQDGPY-QIKEDITTTRYS---IGGLSPNSE 397
Query: 405 IYNFTLNAHNPLGRS--QSTILVNITEKVYPHTPTSFKVKDINSTAVKLSWHLP----GN 458
Y ++A N +G+ +++ E+ P + + + +++T + + W P G
Sbjct: 398 -YEIWVSAVNSIGQGPPSESVVTRTGEQAPASAPRNVQARMLSATTMIVQWEEPVEPNGL 456
Query: 459 FAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYTLYTFRIRCSTETFWK 518
+E + ++ NV + S L + L YT R+ T
Sbjct: 457 IRGYRVYYTMEPEHPVGNWQKHNV------DDSLLTTVGSLLEDETYTVRVLAFTSV--G 508
Query: 519 WSKWSNKKQHLTTEASPSKGPDTWREWSSDGKNLIIYWKPLPINEANGKILSYNVSCSSD 578
S+ Q T + P + P R + ++ + W P P E+ I+ Y +
Sbjct: 509 DGPLSDPIQVKTQQGVPGQ-PMNLRAEARSETSITLSWSP-PRQES---IIKYELLFREG 563
Query: 579 EETQSLSEIPDP--QHKAEIRLDKNDYIISVVAKNSVGSSPPSKIASMEI-------PND 629
+ + + DP + E +Y + A++ G + + P
Sbjct: 564 DHGREVGRTFDPTTSYVVEDLKPNTEYAFRLAARSPQGLGAFTPVVRQRTLQSKPSAPPQ 623
Query: 630 DLKIEQVVGMGKGILLTWHYDPNMTCD-----YVIKWCNSSRSEPCLMDWRKVPSNSTET 684
D+K V IL++W P T + Y +++ +P + +P +T+
Sbjct: 624 DVKCVSV--RSTAILVSWRPPPPETHNGALVGYSVRYRPLGSEDPEPKEVNGIPPTTTQI 681
Query: 685 VIESDEFRPGIRYNFFLYGCRNQGYQLLRSMIGYIEELAPIVAPNFTVEDTSADSILVKW 744
++E+ E R + G + ++ E++ E +A +I V W
Sbjct: 682 LLEALEKWTQYRITTVAHTEVGPGPESSPVVVRTDEDVPSAPPRKVEAEALNATAIRVLW 741
Query: 745 EDIPVEELRGFLRGYLFYFGK--GERDTSKMRVLESGRSDIKVKNITDISQKTLRIADLQ 802
G +RGY ++ + G R+ + +D + + D ++ + I +LQ
Sbjct: 742 RSPAPGRQHGQIRGYQVHYVRMEGAEARGPPRIKDVMLADAQWET-DDTAEYEMVITNLQ 800
Query: 803 GKTSYHLVLRAYTDGGVGPEKSMYVVTKENSV 834
+T+Y + + AYT G G VV + +V
Sbjct: 801 PETAYSITVAAYTMKGDGARSKPKVVVTKGAV 832
Score = 33.1 bits (74), Expect = 1.5
Identities = 31/124 (25%), Positives = 44/124 (35%), Gaps = 12/124 (9%)
Query: 385 AEAPTNESYQLLFQMLPNQEIYNFTLNAHNPLGRSQSTILVNITEKVYPH-TPTSFKVKD 443
A A L Q L Y+ + AH G + V + +P +FKVK
Sbjct: 985 AAAEPGAENALTLQGLKPDTAYDLQVRAHTRRGPGPFSPPVRYRTFLRDQVSPKNFKVKM 1044
Query: 444 INSTAVKLSWHLPGNFAKINFLCEIEIKKSNSVQEQRNVTIKGVENSSYLVALDKLNPYT 503
I T+V LSW P N+ + Q N V+ + + L P+T
Sbjct: 1045 IMKTSVLLSWEFPDNY-----------NSPTPYKIQYNGLTLDVDGRTTKKLITHLKPHT 1093
Query: 504 LYTF 507
Y F
Sbjct: 1094 FYNF 1097
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.133 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,154,517
Number of Sequences: 37866
Number of extensions: 2133181
Number of successful extensions: 6132
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 5193
Number of HSP's gapped (non-prelim): 832
length of query: 1097
length of database: 18,247,518
effective HSP length: 113
effective length of query: 984
effective length of database: 13,968,660
effective search space: 13745161440
effective search space used: 13745161440
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.