Search of human proteins with 4504481

Search of human proteins with 4504481

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504481 hepsin [Homo sapiens]
         (417 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|33695155 hepsin [Homo sapiens]                                     866   0.0  
gi|4504481 hepsin [Homo sapiens]                                      866   0.0  
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   249   2e-66
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         231   1e-60
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          223   2e-58
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   221   7e-58
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   219   4e-57
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          213   3e-55
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   211   1e-54
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   211   1e-54
gi|223942069 enterokinase precursor [Homo sapiens]                    211   1e-54
gi|117956391 protease, serine, 33 [Homo sapiens]                      203   2e-52
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             202   3e-52
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   198   7e-51
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   198   7e-51
gi|4505881 plasminogen [Homo sapiens]                                 197   2e-50
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           196   3e-50
gi|13994276 marapsin [Homo sapiens]                                   195   6e-50
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        195   7e-50
gi|4506153 prostasin preproprotein [Homo sapiens]                     194   2e-49
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           192   6e-49
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        191   1e-48
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         190   2e-48
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       190   2e-48
gi|58218970 protease, serine, 36 [Homo sapiens]                       187   2e-47
gi|4503627 coagulation factor XI precursor [Homo sapiens]             186   3e-47
gi|148613878 acrosin precursor [Homo sapiens]                         186   4e-47
gi|11415040 matriptase [Homo sapiens]                                 185   8e-47
gi|21614531 testisin isoform 2 [Homo sapiens]                         179   3e-45
gi|15559207 elastase 2A preproprotein [Homo sapiens]                  178   7e-45

>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  866 bits (2237), Expect = 0.0
 Identities = 417/417 (100%), Positives = 417/417 (100%)

Query: 1   MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 60
           MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
Sbjct: 1   MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 60

Query: 61  ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 120
           ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
Sbjct: 61  ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 120

Query: 121 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 180
           DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
Sbjct: 121 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 180

Query: 181 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 240
           RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
Sbjct: 181 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 240

Query: 241 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 300
           GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
Sbjct: 241 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 300

Query: 301 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 360
           YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
Sbjct: 301 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 360

Query: 361 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 417
           DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
Sbjct: 361 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 417


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  866 bits (2237), Expect = 0.0
 Identities = 417/417 (100%), Positives = 417/417 (100%)

Query: 1   MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 60
           MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD
Sbjct: 1   MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 60

Query: 61  ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 120
           ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV
Sbjct: 61  ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 120

Query: 121 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 180
           DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL
Sbjct: 121 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 180

Query: 181 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 240
           RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH
Sbjct: 181 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 240

Query: 241 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 300
           GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ
Sbjct: 241 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 300

Query: 301 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 360
           YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE
Sbjct: 301 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 360

Query: 361 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 417
           DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL
Sbjct: 361 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 417


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  249 bits (637), Expect = 2e-66
 Identities = 140/356 (39%), Positives = 192/356 (53%), Gaps = 18/356 (5%)

Query: 54  VQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANG 113
           V+V   +A L VF  T  +W+ +CS       A ++C ++GF   ++   L V +     
Sbjct: 108 VRVGGQNAVLQVF--TAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQF 165

Query: 114 TSGFFCVDEGRLPHTQRLLEVISVC---DCPRGRFLAAICQDCGRRKLPVDRIVGGRDTS 170
              F  +D   LP  +      SV     C  G  +   C  CG R+    RIVGG  + 
Sbjct: 166 REEFVSIDH-LLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSL 224

Query: 171 LGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGL 230
           L +WPWQ SL++ G HLCGGS+++  W++TAAHC  +     S W +  G V+       
Sbjct: 225 LSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPKS-WTIQVGLVSLLDNPAP 283

Query: 231 QLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKI 290
              V+ +VYH  Y P R        NDIAL+ L+ PL   E IQPVCLP + +   DGK+
Sbjct: 284 SHLVEKIVYHSKYKPKR------LGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKV 337

Query: 291 CTVTGWGNTQY-YGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDAC 349
           C  +GWG T+   G  + VL  A VP+ISN +CN  D YG  I P M CAGY  GG+D+C
Sbjct: 338 CWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSC 397

Query: 350 QGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
           QGDSGGP VC++       W+L G  S+G GCA   KPGVYT+V+ F +WI + ++
Sbjct: 398 QGDSGGPLVCQE----RRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQME 449


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  231 bits (588), Expect = 1e-60
 Identities = 134/372 (36%), Positives = 196/372 (52%), Gaps = 29/372 (7%)

Query: 39  IVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRA 98
           +V   L+SD+  L  V+     + L ++  +   W  +CSS  N   +  +C+++GF  A
Sbjct: 214 VVDCKLKSDE--LGCVRFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESA 271

Query: 99  LTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKL 158
              +E+  R          F      L +   + E +   +CP  R+++  C  CG R +
Sbjct: 272 HRTTEVAHRD---------FANSFSILRYNSTIQESLHRSECPSQRYISLQCSHCGLRAM 322

Query: 159 PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHC-FPERNRVLSRWRV 217
              RIVGG   S  +WPWQVSL +   H+CGG+L+   WVLTAAHC F  R +VL  W+V
Sbjct: 323 -TGRIVGGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKV 381

Query: 218 FAGAVAQASPHGL--QLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQP 275
           +AG    ++ H L     +  ++ +  Y        EE+  DIAL+ LS PL L+ +I P
Sbjct: 382 YAGT---SNLHQLPEAASIAEIIINSNY------TDEEDDYDIALMRLSKPLTLSAHIHP 432

Query: 276 VCLPAAGQALVDGKICTVTGWGNTQYYGQQAG-VLQEARVPIISNDVCNGADFYGNQIKP 334
            CLP  GQ     + C +TG+G T+    +    L+E +V +I    CN    Y + + P
Sbjct: 433 ACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTP 492

Query: 335 KMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVS 394
           +M CAG   GG D+CQGDSGGP VCE    +  RW L G+ SWGTGC    KPGVYTKV+
Sbjct: 493 RMMCAGDLRGGRDSCQGDSGGPLVCE----QNNRWYLAGVTSWGTGCGQRNKPGVYTKVT 548

Query: 395 DFREWIFQAIKT 406
           +   WI+  +++
Sbjct: 549 EVLPWIYSKMES 560


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  223 bits (569), Expect = 2e-58
 Identities = 141/412 (34%), Positives = 201/412 (48%), Gaps = 51/412 (12%)

Query: 24  GTLLLLTAIGAASWAIVAVLLRSDQEPLYPV-----------QVSSADARLMVFDKT--- 69
           G L LL   G  SW +V  L  +  +P+              + S+ +A L    KT   
Sbjct: 53  GALGLLAGAGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSF 112

Query: 70  ---------------EGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGT 114
                          +  W L+C    +  +    C  +G LR   H  +++     N +
Sbjct: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172

Query: 115 SGFFCVDEGRLPHTQRLLEVI--SVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLG 172
             F  +     P     LE       +C  G+ ++  C +CG R L   RIVGG+  + G
Sbjct: 173 QEFAQLS----PRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPL-ASRIVGGQSVAPG 227

Query: 173 RWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPE-RNRVLSRWRVFAGAVAQAS--PHG 229
           RWPWQ S+     H CGGS+L+  WV+TAAHC    R   LS WRV AG V+ ++  PH 
Sbjct: 228 RWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQ 287

Query: 230 LQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGK 289
             L V+ ++ H  Y      +++ +  D+AL+ L + L  ++ +  VCLPA  Q    G 
Sbjct: 288 GAL-VERIIPHPLY------SAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGS 340

Query: 290 ICTVTGWGNTQ-YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDA 348
            C V+GWG+T   +   + +LQ+  VP+ S  +CN +  Y   + P+M CAGY +G  DA
Sbjct: 341 RCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADA 400

Query: 349 CQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400
           CQGDSGGP VC D       WRL G+VSWG GCA    PGVY KV++F +WI
Sbjct: 401 CQGDSGGPLVCPDG----DTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  221 bits (564), Expect = 7e-58
 Identities = 129/360 (35%), Positives = 179/360 (49%), Gaps = 34/360 (9%)

Query: 50  PLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALT---HSELDV 106
           P   V++S   + L V D   G W   C       +A  +C +MG+ RA+      +LDV
Sbjct: 100 PAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSRAVEIGPDQDLDV 159

Query: 107 RTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGG 166
                N               +Q L    S   C  G  ++  C  CG+  L   R+VGG
Sbjct: 160 VEITEN---------------SQELRMRNSSGPCLSGSLVSLHCLACGK-SLKTPRVVGG 203

Query: 167 RDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS 226
            + S+  WPWQVS++YD  H+CGGS+L   WVLTAAHCF +   V + W+V AG+    S
Sbjct: 204 EEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFN-WKVRAGSDKLGS 262

Query: 227 PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALV 286
              L +    ++      P          NDIAL+ L  PL  +  ++P+CLP   + L 
Sbjct: 263 FPSLAVAKIIIIEFNPMYP--------KDNDIALMKLQFPLTFSGTVRPICLPFFDEELT 314

Query: 287 DGKICTVTGWGNT-QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGG 345
                 + GWG T Q  G+ + +L +A V +I +  CN  D Y  ++  KM CAG PEGG
Sbjct: 315 PATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGG 374

Query: 346 IDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
           +D CQGDSGGP + +     + +W + GIVSWG GC     PGVYTKVS +  WI+   K
Sbjct: 375 VDTCQGDSGGPLMYQ-----SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWK 429


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  219 bits (558), Expect = 4e-57
 Identities = 126/357 (35%), Positives = 180/357 (50%), Gaps = 23/357 (6%)

Query: 50  PLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTA 109
           P   V++S   + L V D   G W   C       +A  +C +MG+    T   +++   
Sbjct: 100 PAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETACRQMGYSSKPTFRAVEI--- 156

Query: 110 GANGTSGFFCVDEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDT 169
           G +       + E    ++Q L    S   C  G  ++  C  CG+  L   R+VGG + 
Sbjct: 157 GPDQDLDVVEITE----NSQELRMRNSSGPCLSGSLVSLHCLACGK-SLKTPRVVGGEEA 211

Query: 170 SLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHG 229
           S+  WPWQVS++YD  H+CGGS+L   WVLTAAHCF +   V + W+V AG+    S   
Sbjct: 212 SVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKHTDVFN-WKVRAGSDKLGSFPS 270

Query: 230 LQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGK 289
           L +    ++      P          NDIAL+ L  PL  +  ++P+CLP   + L    
Sbjct: 271 LAVAKIIIIEFNPMYP--------KDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPAT 322

Query: 290 ICTVTGWGNT-QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDA 348
              + GWG T Q  G+ + +L +A V +I +  CN  D Y  ++  KM CAG PEGG+D 
Sbjct: 323 PLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDT 382

Query: 349 CQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
           CQGDSGGP + +     + +W + GIVSWG GC     PGVYTKVS +  WI+   K
Sbjct: 383 CQGDSGGPLMYQ-----SDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWIYNVWK 434


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  213 bits (541), Expect = 3e-55
 Identities = 113/245 (46%), Positives = 144/245 (58%), Gaps = 12/245 (4%)

Query: 158 LPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRV 217
           L   RI+GG +   G WPWQVSLR + AH CGGSL++  W+LTAAHCF  R+    R  +
Sbjct: 182 LSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCF--RSNSNPRDWI 239

Query: 218 FAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVC 277
               ++   P  L++ V+ ++ H  Y       S  + NDIALV L + +  T+ I  VC
Sbjct: 240 ATSGISTTFPK-LRMRVRNILIHNNY------KSATHENDIALVRLENSVTFTKDIHSVC 292

Query: 278 LPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMF 337
           LPAA Q +  G    VTGWG  +Y G     L++ +V IISNDVCN    Y   I   M 
Sbjct: 293 LPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGML 352

Query: 338 CAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFR 397
           CAG P+GG+DACQGDSGGP V EDS      W + GIVSWG  C L  KPGVYT+V+ + 
Sbjct: 353 CAGVPQGGVDACQGDSGGPLVQEDS---RRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYL 409

Query: 398 EWIFQ 402
           +WI Q
Sbjct: 410 DWIRQ 414


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  211 bits (537), Expect = 1e-54
 Identities = 118/346 (34%), Positives = 174/346 (50%), Gaps = 17/346 (4%)

Query: 63  LMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDE 122
           L V+     +W  +C    N      +C +MG+      S+  V  +G+           
Sbjct: 195 LQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLN-TSA 253

Query: 123 GRLPHTQRLLEVISVCDCPRGRFLAAICQDCG--RRKLPVDRIVGGRDTSLGRWPWQVSL 180
           G +   ++L    +   C     ++  C  CG         RIVGG     G WPWQVSL
Sbjct: 254 GNVDIYKKLYHSDA---CSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSL 310

Query: 181 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASP-HGLQLGVQAVVY 239
                H+CGGS+++ +W++TAAHC  +       W  FAG + Q+   +G    V+ V+ 
Sbjct: 311 HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVIS 370

Query: 240 HGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNT 299
           H  Y      +S+  +NDIAL+ L  PL   + ++PVCLP  G  L   ++C ++GWG T
Sbjct: 371 HPNY------DSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGAT 424

Query: 300 QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVC 359
           +  G+ + VL  A+V +I    CN    Y N I P M CAG+ +G +D+CQGDSGGP V 
Sbjct: 425 EEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLV- 483

Query: 360 EDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
               S+   W L G  SWG+GCA A +PGVY  V  F +WI++ ++
Sbjct: 484 ---TSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMR 526


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  211 bits (537), Expect = 1e-54
 Identities = 118/346 (34%), Positives = 174/346 (50%), Gaps = 17/346 (4%)

Query: 63  LMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDE 122
           L V+     +W  +C    N      +C +MG+      S+  V  +G+           
Sbjct: 158 LQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDDSGSTSFMKLN-TSA 216

Query: 123 GRLPHTQRLLEVISVCDCPRGRFLAAICQDCG--RRKLPVDRIVGGRDTSLGRWPWQVSL 180
           G +   ++L    +   C     ++  C  CG         RIVGG     G WPWQVSL
Sbjct: 217 GNVDIYKKLYHSDA---CSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGAWPWQVSL 273

Query: 181 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASP-HGLQLGVQAVVY 239
                H+CGGS+++ +W++TAAHC  +       W  FAG + Q+   +G    V+ V+ 
Sbjct: 274 HVQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQSFMFYGAGYQVEKVIS 333

Query: 240 HGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNT 299
           H  Y      +S+  +NDIAL+ L  PL   + ++PVCLP  G  L   ++C ++GWG T
Sbjct: 334 HPNY------DSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWGAT 387

Query: 300 QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVC 359
           +  G+ + VL  A+V +I    CN    Y N I P M CAG+ +G +D+CQGDSGGP V 
Sbjct: 388 EEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGPLV- 446

Query: 360 EDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIK 405
               S+   W L G  SWG+GCA A +PGVY  V  F +WI++ ++
Sbjct: 447 ---TSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIYRQMR 489


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  211 bits (536), Expect = 1e-54
 Identities = 108/256 (42%), Positives = 145/256 (56%), Gaps = 17/256 (6%)

Query: 151  QDCGRRKLPVD---RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPE 207
            + CG++    D   +IVGG +   G WPW V L Y G  LCG SL+S DW+++AAHC   
Sbjct: 770  KSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGGRLLCGASLVSSDWLVSAAHCVYG 829

Query: 208  RNRVLSRWRVFAGAVAQA---SPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLS 264
            RN   S+W    G   ++   SP  +   +  +V +  Y      N     NDIA++HL 
Sbjct: 830  RNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINPHY------NRRRKDNDIAMMHLE 883

Query: 265  SPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNG 324
              +  T+YIQP+CLP   Q    G+ C++ GWG   Y G  A +LQEA VP++SN+ C  
Sbjct: 884  FKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTANILQEADVPLLSNERCQ- 942

Query: 325  ADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALA 384
                   I   M CAGY EGGID+CQGDSGGP +C+++     RW L G+ S+G  CAL 
Sbjct: 943  QQMPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQEN----NRWFLAGVTSFGYKCALP 998

Query: 385  QKPGVYTKVSDFREWI 400
             +PGVY +VS F EWI
Sbjct: 999  NRPGVYARVSRFTEWI 1014


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  203 bits (517), Expect = 2e-52
 Identities = 116/265 (43%), Positives = 151/265 (56%), Gaps = 35/265 (13%)

Query: 153 CGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVL 212
           CG+ ++   RIVGGRD   G WPWQ S+++ GAH+CGGSL++  WVLTAAHCFP R  + 
Sbjct: 28  CGQPRMS-SRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFP-RRALP 85

Query: 213 SRWRVFAGA--VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENS-NDIALVHLSSPLPL 269
           + +RV  GA  +   SP  L + V+ V+    Y       SE+ +  D+AL+ L  P+PL
Sbjct: 86  AEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDY-------SEDGARGDLALLQLRRPVPL 138

Query: 270 TEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGV-------LQEARVPIISNDVC 322
           +  +QPVCLP  G     G  C VTGWG+      + GV       LQ  RVP++ +  C
Sbjct: 139 SARVQPVCLPVPGARPPPGTPCRVTGWGSL-----RPGVPLPEWRPLQGVRVPLLDSRTC 193

Query: 323 NGADFYGNQIK-------PKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIV 375
           +G    G  +        P   CAGYP+G  DACQGDSGGP  C  S S    W L G+V
Sbjct: 194 DGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGS----WVLVGVV 249

Query: 376 SWGTGCALAQKPGVYTKVSDFREWI 400
           SWG GCAL  +PGVYT V+ +  WI
Sbjct: 250 SWGKGCALPNRPGVYTSVATYSPWI 274


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  202 bits (515), Expect = 3e-52
 Identities = 106/255 (41%), Positives = 152/255 (59%), Gaps = 25/255 (9%)

Query: 162 RIVGGRDTSLGRWPWQVSLRYD---GAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVF 218
           RIVGG ++S G WPWQVSL+       HLCGGSL+   WVLTAAHCF +   +   WR++
Sbjct: 390 RIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCF-DGLPLQDVWRIY 448

Query: 219 AGA-----VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYI 273
           +G      + + +P      ++ ++ H  Y         E ++DIAL+ L +PL  TE+ 
Sbjct: 449 SGILNLSDITKDTPFSQ---IKEIIIHQNY------KVSEGNHDIALIKLQAPLNYTEFQ 499

Query: 274 QPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIK 333
           +P+CLP+ G        C VTGWG ++  G+   +LQ+  +P+++N+ C    +   +I 
Sbjct: 500 KPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEECQ-KRYQDYKIT 558

Query: 334 PKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKV 393
            +M CAGY EGG DAC+GDSGGP VC+        WRL GI SWG GCA  ++PGVYTKV
Sbjct: 559 QRMVCAGYKEGGKDACKGDSGGPLVCK----HNGMWRLVGITSWGEGCARREQPGVYTKV 614

Query: 394 SDFREWIFQAIKTHS 408
           +++ +WI +  KT S
Sbjct: 615 AEYMDWILE--KTQS 627


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  198 bits (504), Expect = 7e-51
 Identities = 107/250 (42%), Positives = 142/250 (56%), Gaps = 14/250 (5%)

Query: 153 CGRRKLP--VDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNR 210
           CG+R +P  V+RI  G       WPWQ SL+YD  H CG +L+S  W++TAAHCF ++ +
Sbjct: 175 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCF-QKYK 233

Query: 211 VLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
              +W V  G   + +P  ++  V+  + H  Y       S     DIA+V +SS +  +
Sbjct: 234 NPHQWTVSFGT--KINPPLMKRNVRRFIIHEKY------RSAAREYDIAVVQVSSRVTFS 285

Query: 271 EYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330
           + I+ +CLP A  +        +TG+G   Y G+    L+EARV IIS+DVC     YGN
Sbjct: 286 DDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGN 345

Query: 331 QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390
            IKP MFCAGY EG  DAC+GDSGGP V  D       W L GIVSWG  C    KPGVY
Sbjct: 346 DIKPGMFCAGYMEGIYDACRGDSGGPLVTRD---LKDTWYLIGIVSWGDNCGQKDKPGVY 402

Query: 391 TKVSDFREWI 400
           T+V+ +R WI
Sbjct: 403 TQVTYYRNWI 412


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  198 bits (504), Expect = 7e-51
 Identities = 107/250 (42%), Positives = 142/250 (56%), Gaps = 14/250 (5%)

Query: 153 CGRRKLP--VDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNR 210
           CG+R +P  V+RI  G       WPWQ SL+YD  H CG +L+S  W++TAAHCF ++ +
Sbjct: 178 CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCF-QKYK 236

Query: 211 VLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
              +W V  G   + +P  ++  V+  + H  Y       S     DIA+V +SS +  +
Sbjct: 237 NPHQWTVSFGT--KINPPLMKRNVRRFIIHEKY------RSAAREYDIAVVQVSSRVTFS 288

Query: 271 EYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330
           + I+ +CLP A  +        +TG+G   Y G+    L+EARV IIS+DVC     YGN
Sbjct: 289 DDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGN 348

Query: 331 QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390
            IKP MFCAGY EG  DAC+GDSGGP V  D       W L GIVSWG  C    KPGVY
Sbjct: 349 DIKPGMFCAGYMEGIYDACRGDSGGPLVTRD---LKDTWYLIGIVSWGDNCGQKDKPGVY 405

Query: 391 TKVSDFREWI 400
           T+V+ +R WI
Sbjct: 406 TQVTYYRNWI 415


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  197 bits (500), Expect = 2e-50
 Identities = 125/330 (37%), Positives = 173/330 (52%), Gaps = 37/330 (11%)

Query: 85  VAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDE-----GRLPHTQRLLEVISVCD 139
           V G  C++        HS     T    G    +C +      G   +T    ++   CD
Sbjct: 497 VTGTPCQDWAAQEPHRHSIFTPETNPRAGLEKNYCRNPDGDVGGPWCYTTNPRKLYDYCD 556

Query: 140 CPRGRFLAAICQDCGR-----RKLPVDRIVGGRDTSLGRWPWQVSLRYD-GAHLCGGSLL 193
            P+    AA   DCG+     +K P  R+VGG       WPWQVSLR   G H CGG+L+
Sbjct: 557 VPQ---CAAPSFDCGKPQVEPKKCP-GRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLI 612

Query: 194 SGDWVLTAAHCFPERNRVLSRWRVFAGAVAQAS--PHGLQLGVQAVVYHGGYLPFRDPNS 251
           S +WVLTAAHC  +  R  S ++V  GA  + +  PH  ++ V  +        F +P  
Sbjct: 613 SPEWVLTAAHCLEKSPRP-SSYKVILGAHQEVNLEPHVQEIEVSRL--------FLEPTR 663

Query: 252 EENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ-YYGQQAGVLQ 310
           +    DIAL+ LSSP  +T+ + P CLP+    + D   C +TGWG TQ  +G  AG+L+
Sbjct: 664 K----DIALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQGTFG--AGLLK 717

Query: 311 EARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWR 370
           EA++P+I N VCN  +F   +++    CAG+  GG D+CQGDSGGP VC +      ++ 
Sbjct: 718 EAQLPVIENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEK----DKYI 773

Query: 371 LCGIVSWGTGCALAQKPGVYTKVSDFREWI 400
           L G+ SWG GCA   KPGVY +VS F  WI
Sbjct: 774 LQGVTSWGLGCARPNKPGVYVRVSRFVTWI 803


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  196 bits (499), Expect = 3e-50
 Identities = 106/256 (41%), Positives = 148/256 (57%), Gaps = 15/256 (5%)

Query: 152 DCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRV 211
           DCG +  P  RIVGG  +S G WPWQ SL+  G H+CGG+L++  WV+TAAHCF E +  
Sbjct: 567 DCGLQG-PSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMA 625

Query: 212 LS-RWRVFAGAVAQAS--PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLP 268
            +  W VF G V Q S  P  +   V  ++ H    P+ + +S +   D+AL+ L  P+ 
Sbjct: 626 STVLWTVFLGKVWQNSRWPGEVSFKVSRLLLH----PYHEEDSHD--YDVALLQLDHPVV 679

Query: 269 LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFY 328
            +  ++PVCLPA       G  C +TGWG  +  G  +  LQ+  V +I  D+C  ++ Y
Sbjct: 680 RSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLC--SEVY 737

Query: 329 GNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPG 388
             Q+ P+M CAGY +G  DACQGDSGGP VC+   + + RW L G+VSWG GC      G
Sbjct: 738 RYQVTPRMLCAGYRKGKKDACQGDSGGPLVCK---ALSGRWFLAGLVSWGLGCGRPNYFG 794

Query: 389 VYTKVSDFREWIFQAI 404
           VYT+++    WI Q +
Sbjct: 795 VYTRITGVISWIQQVV 810


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  195 bits (496), Expect = 6e-50
 Identities = 109/263 (41%), Positives = 145/263 (55%), Gaps = 23/263 (8%)

Query: 153 CGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVL 212
           CGR ++ ++R+VGG+DT  G WPWQVS++ +G+H CGGSL++  WVLTAAHCF   +   
Sbjct: 26  CGRPRM-LNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRNTSET- 83

Query: 213 SRWRVFAGA--VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
           S ++V  GA  + Q  PH +   V+ V  +  Y          +S D+ALV L +P+P T
Sbjct: 84  SLYQVLLGARQLVQPGPHAMYARVRQVESNPLY------QGTASSADVALVELEAPVPFT 137

Query: 271 EYIQPVCLPAAGQALVDGKICTVTGWGNTQYYG--QQAGVLQEARVPIISNDVCN----- 323
            YI PVCLP        G  C VTGWG+        +  +LQ+  VPII    CN     
Sbjct: 138 NYILPVCLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSK 197

Query: 324 --GADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGC 381
                +    IK  M CAG+ EG  DAC+GDSGGP VC    S    W   G++SWG GC
Sbjct: 198 DTEFGYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQS----WLQAGVISWGEGC 253

Query: 382 ALAQKPGVYTKVSDFREWIFQAI 404
           A   +PGVY +V+    WI + I
Sbjct: 254 ARQNRPGVYIRVTAHHNWIHRII 276


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  195 bits (495), Expect = 7e-50
 Identities = 108/241 (44%), Positives = 145/241 (60%), Gaps = 15/241 (6%)

Query: 162 RIVGGRDTSL-GRWPWQVSLRYDGA-HLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFA 219
           RIV GR+T++ G WPWQ SL+  G+ H CG SL+S  W+LTAAHCF  +N+  ++W    
Sbjct: 205 RIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCF-WKNKDPTQWIATF 263

Query: 220 GAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279
           GA    +P  ++  V+ ++ H  Y      + E N NDIALV LS+ +  +  +Q VCLP
Sbjct: 264 GATI--TPPAVKRNVRKIILHENY------HRETNENDIALVQLSTGVEFSNIVQRVCLP 315

Query: 280 AAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCA 339
            +   L       VTG+G+    G     L++ARV  IS DVCN  D Y   I P M CA
Sbjct: 316 DSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCA 375

Query: 340 GYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREW 399
           G+ EG IDAC+GDSGGP V ++       W + GIVSWG  CAL +KPGVYT+V+ +R+W
Sbjct: 376 GFMEGKIDACKGDSGGPLVYDNH----DIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431

Query: 400 I 400
           I
Sbjct: 432 I 432


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  194 bits (492), Expect = 2e-49
 Identities = 107/253 (42%), Positives = 137/253 (54%), Gaps = 23/253 (9%)

Query: 159 PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFP-ERNRVLSRWRV 217
           P  RI GG     G+WPWQVS+ Y+G H+CGGSL+S  WVL+AAHCFP E ++     ++
Sbjct: 41  PQARITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEAYEVKL 100

Query: 218 FAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVC 277
            A  +   S       ++ ++ H  YL       E +  DIAL+ LS P+  + YI+P+C
Sbjct: 101 GAHQLDSYSEDAKVSTLKDIIPHPSYL------QEGSQGDIALLQLSRPITFSRYIRPIC 154

Query: 278 LPAAGQALVDGKICTVTGWGNT--QYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPK 335
           LPAA  +  +G  CTVTGWG+            LQ+  VP+IS + CN    Y    KP+
Sbjct: 155 LPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCN--CLYNIDAKPE 212

Query: 336 --------MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387
                   M CAGY EGG DACQGDSGGP  C         W L GIVSWG  C    +P
Sbjct: 213 EPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVE----GLWYLTGIVSWGDACGARNRP 268

Query: 388 GVYTKVSDFREWI 400
           GVYT  S +  WI
Sbjct: 269 GVYTLASSYASWI 281


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  192 bits (487), Expect = 6e-49
 Identities = 101/245 (41%), Positives = 147/245 (60%), Gaps = 15/245 (6%)

Query: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221
           RIVGG + S G +PWQ SLR +  H CG ++++  W+++AAHCF E     ++W  + GA
Sbjct: 202 RIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQDP-TKWVAYVGA 260

Query: 222 VAQASPHGLQLGVQAV--VYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279
              +      +  Q V  V H  Y      N++    D+A++ L+SPLP   +IQPVCLP
Sbjct: 261 TYLSGSEASTVRAQVVQIVKHPLY------NADTADFDVAVLELTSPLPFGRHIQPVCLP 314

Query: 280 AAGQALVDGKICTVTGWGN-TQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFC 338
           AA       K C ++GWG   + +  +  VLQ+A V ++   +C  A  YG+ +  +M C
Sbjct: 315 AATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHSLTDRMVC 372

Query: 339 AGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFRE 398
           AGY +G +D+CQGDSGGP VCE+    + R+ L GIVSWG GCA A++PGVY +V+  R+
Sbjct: 373 AGYLDGKVDSCQGDSGGPLVCEEP---SGRFFLAGIVSWGIGCAEARRPGVYARVTRLRD 429

Query: 399 WIFQA 403
           WI +A
Sbjct: 430 WILEA 434



 Score =  181 bits (459), Expect = 1e-45
 Identities = 98/255 (38%), Positives = 132/255 (51%), Gaps = 13/255 (5%)

Query: 152  DCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGA-HLCGGSLLSGDWVLTAAHCFPERNR 210
            DCG     + RIVGG     G WPWQVSL      H CG  L++  W+L+AAHCF     
Sbjct: 816  DCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD 875

Query: 211  VLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLT 270
               +W  F G    +   G    V  +  H  Y      N      D+AL+ L+ P+  +
Sbjct: 876  P-KQWAAFLGTPFLSGAEGQLERVARIYKHPFY------NLYTLDYDVALLELAGPVRRS 928

Query: 271  EYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGN 330
              ++P+CLP       DG  C +TGWG+ +  G  A  LQ+A V ++S   C    FY  
Sbjct: 929  RLVRPICLPEPAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCR--RFYPV 986

Query: 331  QIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVY 390
            QI  +M CAG+P+GG+D+C GD+GGP  C +    + RW L G+ SWG GC     PGVY
Sbjct: 987  QISSRMLCAGFPQGGVDSCSGDAGGPLACREP---SGRWVLTGVTSWGYGCGRPHFPGVY 1043

Query: 391  TKVSDFREWIFQAIK 405
            T+V+  R WI Q I+
Sbjct: 1044 TRVAAVRGWIGQHIQ 1058



 Score =  181 bits (458), Expect = 1e-45
 Identities = 99/259 (38%), Positives = 146/259 (56%), Gaps = 14/259 (5%)

Query: 151 QDCGRRKL--PVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPER 208
           Q+CG R       R+VGG   + G  PWQVSL+    H CG +++   W+L+AAHCF   
Sbjct: 490 QECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHCFNHT 549

Query: 209 NRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLP 268
                R  +   ++       +++G++ VV H    P  +P   +   D+A++ L+SPL 
Sbjct: 550 KVEQVRAHLGTASLLGLGGSPVKIGLRRVVLH----PLYNPGILDF--DLAVLELASPLA 603

Query: 269 LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQY-YGQQAGVLQEARVPIISNDVCNGADF 327
             +YIQPVCLP A Q    G+ C ++GWGNTQ     +  +LQ+A V II    C  +  
Sbjct: 604 FNKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTC--SVL 661

Query: 328 YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387
           Y   +  +M CAG+ EG +D+CQGDSGGP  CE++      + L GIVSWG GCA  +KP
Sbjct: 662 YNFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEA---PGVFYLAGIVSWGIGCAQVKKP 718

Query: 388 GVYTKVSDFREWIFQAIKT 406
           GVYT+++  + WI + + +
Sbjct: 719 GVYTRITRLKGWILEIMSS 737


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  191 bits (485), Expect = 1e-48
 Identities = 103/252 (40%), Positives = 139/252 (55%), Gaps = 16/252 (6%)

Query: 153 CGRRK----LPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPER 208
           CGR+     +  ++IV G+ +  G WPWQ S+++ G H CG SL+S  W+L+AAHCF ++
Sbjct: 171 CGRQVANSIITGNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWLLSAAHCFAKK 230

Query: 209 NRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLP 268
           N     W V  G V    P+ +   VQ +++H  Y      +S    +DIALV L+  + 
Sbjct: 231 NNSKD-WTVNFGIVVN-KPY-MTRKVQNIIFHENY------SSPGLHDDIALVQLAEEVS 281

Query: 269 LTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFY 328
            TEYI+ +CLP A   L +     VTGWG     G    +LQE  + II N +CN +  Y
Sbjct: 282 FTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAY 341

Query: 329 GNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPG 388
              +   M CAG+  G  DACQ DSGGP    DS +    W L GIVSWG GC    KPG
Sbjct: 342 SGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRN---IWHLVGIVSWGDGCGKKNKPG 398

Query: 389 VYTKVSDFREWI 400
           VYT+V+ +R WI
Sbjct: 399 VYTRVTSYRNWI 410


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  190 bits (482), Expect = 2e-48
 Identities = 98/239 (41%), Positives = 133/239 (55%), Gaps = 12/239 (5%)

Query: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221
           RIVGG +   G WPWQ SL++DG+H CG +L++  W+++AAHCF       +RW    G 
Sbjct: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP-ARWTASFGV 249

Query: 222 VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281
             +  P  ++ G++ ++ H  Y          +  DI+L  LSSP+P T  +  VCLP A
Sbjct: 250 TIK--PSKMKRGLRRIIVHEKY------KHPSHDYDISLAELSSPVPYTNAVHRVCLPDA 301

Query: 282 GQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGY 341
                 G +  VTG+G  +  G     L++A+V +I    CN    Y + I P+M CAG 
Sbjct: 302 SYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGS 361

Query: 342 PEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400
            EG  DACQGDSGGP V  D+      W L GIVSWG  CA   KPGVYT+V+  R+WI
Sbjct: 362 LEGKTDACQGDSGGPLVSSDA---RDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  190 bits (482), Expect = 2e-48
 Identities = 98/239 (41%), Positives = 133/239 (55%), Gaps = 12/239 (5%)

Query: 162 RIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGA 221
           RIVGG +   G WPWQ SL++DG+H CG +L++  W+++AAHCF       +RW    G 
Sbjct: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP-ARWTASFGV 249

Query: 222 VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA 281
             +  P  ++ G++ ++ H  Y          +  DI+L  LSSP+P T  +  VCLP A
Sbjct: 250 TIK--PSKMKRGLRRIIVHEKY------KHPSHDYDISLAELSSPVPYTNAVHRVCLPDA 301

Query: 282 GQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGY 341
                 G +  VTG+G  +  G     L++A+V +I    CN    Y + I P+M CAG 
Sbjct: 302 SYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGS 361

Query: 342 PEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400
            EG  DACQGDSGGP V  D+      W L GIVSWG  CA   KPGVYT+V+  R+WI
Sbjct: 362 LEGKTDACQGDSGGPLVSSDA---RDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  187 bits (475), Expect = 2e-47
 Identities = 110/277 (39%), Positives = 138/277 (49%), Gaps = 23/277 (8%)

Query: 152 DCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRV 211
           DCGR + P  RIVGG +   G WPWQVSL + G H+CGGSL++  WVL+AAHCF     +
Sbjct: 37  DCGRPE-PSARIVGGSNAQPGTWPWQVSLHHGGGHICGGSLIAPSWVLSAAHCFMTNGTL 95

Query: 212 --LSRWRVFAGAVAQASP--HGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPL 267
              + W V  G  +Q  P        V A+V    Y      +  E   D+AL+ L+SP 
Sbjct: 96  EPAAEWSVLLGVHSQDGPLDGAHTRAVAAIVVPANY------SQVELGADLALLRLASPA 149

Query: 268 PLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYG--QQAGVLQEARVPIISNDVCN-- 323
            L   + PVCLP A    V G  C  TGWG+ Q         VLQE  + ++    C   
Sbjct: 150 SLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEADPLPLPWVLQEVELRLLGEATCQCL 209

Query: 324 ----GADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGT 379
               G      QI P M CAGYPEG  D CQGDSGGP VCE+      RW   GI S+G 
Sbjct: 210 YSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGDSGGPLVCEEG----GRWFQAGITSFGF 265

Query: 380 GCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQ 416
           GC    +PGV+T V+ +  WI + +          TQ
Sbjct: 266 GCGRRNRPGVFTAVATYEAWIREQVMGSEPGPAFPTQ 302



 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 70/253 (27%), Positives = 106/253 (41%), Gaps = 46/253 (18%)

Query: 166 GRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERN------RVLSRWRVFA 219
           G+    G WPW+  +   G+  C G+L+S  WVL  A CF + N      R L  WRV  
Sbjct: 326 GKAPRPGAWPWEAQVMVPGSRPCHGALVSESWVLAPASCFLDPNSSDSPPRDLDAWRVLL 385

Query: 220 GAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279
            +  +A        V  +V H       +  S +N++D+AL+ L +P+ L+   +PVCLP
Sbjct: 386 PSRPRAE------RVARLVQH-------ENASWDNASDLALLQLRTPVNLSAASRPVCLP 432

Query: 280 AAGQALVDGKICTVTGWGNTQYYGQQA---GVLQEARVPIISNDVCNGADFYGNQ----- 331
                 + G  C +  WG     G+ A   G L EA   ++    C+    YG Q     
Sbjct: 433 HPEHYFLPGSRCRLARWGR----GEPALGPGALLEAE--LLGGWWCH--CLYGRQGAAVP 484

Query: 332 ---IKPKMFCAGYPE-GGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387
                P   C  Y E   + +C  DS    +C++       W L GI  + +GC    +P
Sbjct: 485 LPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEE----GTWFLAGIRDFPSGCL---RP 537

Query: 388 GVYTKVSDFREWI 400
             +  +     WI
Sbjct: 538 RAFFPLQTHGPWI 550



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 59/209 (28%), Positives = 87/209 (41%), Gaps = 23/209 (11%)

Query: 174 WPWQVSLRYDGAHLCGGSLLSGDWVLTAAHC-FPERNRVLSRWRVFAG-AVAQASPHGLQ 231
           WPW   +   G  +C G LL+  WVL A HC     +  +    V+ G A A + P G Q
Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSLPQGHQ 660

Query: 232 LGVQAV-VYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKI 290
           +    + +    +L  R P        +AL+ LSS +  +    P+CL  AG  +  G  
Sbjct: 661 VSRLVISIRLPQHLGLRPP--------LALLELSSRVEPSPSALPICLHPAG--IPPGAS 710

Query: 291 CTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQ 350
           C V GW        Q  V   A V I++  +C+    Y   + P   C  Y EG  + C+
Sbjct: 711 CWVLGWKE-----PQDRVPVAAAVSILTQRICD--CLYQGILPPGTLCVLYAEGQENRCE 763

Query: 351 GDSGGPFVCEDSISRTPRWRLCGIVSWGT 379
             S  P +C+        W L G+   G+
Sbjct: 764 MTSAPPLLCQ---MTEGSWILVGMAVQGS 789


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  186 bits (473), Expect = 3e-47
 Identities = 101/248 (40%), Positives = 142/248 (57%), Gaps = 21/248 (8%)

Query: 162 RIVGGRDTSLGRWPWQVSLRYDGA---HLCGGSLLSGDWVLTAAHCF--PERNRVLSRWR 216
           RIVGG  +  G WPWQV+L        HLCGGS++   W+LTAAHCF   E  ++L   R
Sbjct: 387 RIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGVESPKIL---R 443

Query: 217 VFAGAVAQAS--PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQ 274
           V++G + Q+         GVQ ++ H  Y         E+  DIAL+ L + +  T+  +
Sbjct: 444 VYSGILNQSEIKEDTSFFGVQEIIIHDQY------KMAESGYDIALLKLETTVNYTDSQR 497

Query: 275 PVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKP 334
           P+CLP+ G   V    C VTGWG  +   +    LQ+A++P+++N+ C    + G++I  
Sbjct: 498 PICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQ-KRYRGHKITH 556

Query: 335 KMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVS 394
           KM CAGY EGG DAC+GDSGGP  C+        W L GI SWG GCA  ++PGVYT V 
Sbjct: 557 KMICAGYREGGKDACKGDSGGPLSCK----HNEVWHLVGITSWGEGCAQRERPGVYTNVV 612

Query: 395 DFREWIFQ 402
           ++ +WI +
Sbjct: 613 EYVDWILE 620


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  186 bits (471), Expect = 4e-47
 Identities = 111/267 (41%), Positives = 145/267 (54%), Gaps = 25/267 (9%)

Query: 162 RIVGGRDTSLGRWPWQVSLR---YDGA--HLCGGSLLSGDWVLTAAHCFPERNRVLSRWR 216
           RIVGG+    G WPW VSL+   Y+    H CGGSLL+  WVLTAAHCF  +N V   WR
Sbjct: 42  RIVGGKAAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHD-WR 100

Query: 217 VFAGA----VAQASPHGLQLG---VQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPL 269
           +  GA         P    L    V+ ++ H  Y      NS    NDIALV ++ P+  
Sbjct: 101 LVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKY------NSATEGNDIALVEITPPISC 154

Query: 270 TEYIQPVCLPAAGQALVDG-KICTVTGWGNTQYYGQQ-AGVLQEARVPIISNDVCNGADF 327
             +I P CLP     L  G + C V GWG  +    + + +L EARV +I  D+CN   +
Sbjct: 155 GRFIGPGCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQW 214

Query: 328 YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKP 387
           Y  +++P   CAGYP G ID CQGDSGGP +C+D  S+   + + GI SWG GCA A++P
Sbjct: 215 YNGRVQPTNVCAGYPVGKIDTCQGDSGGPLMCKD--SKESAYVVVGITSWGVGCARAKRP 272

Query: 388 GVYTKVSDFREWIFQAIKTHSEASGMV 414
           G+YT    +  WI  A K  S A  M+
Sbjct: 273 GIYTATWPYLNWI--ASKIGSNALRMI 297


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  185 bits (469), Expect = 8e-47
 Identities = 105/258 (40%), Positives = 143/258 (55%), Gaps = 20/258 (7%)

Query: 152 DCGRRKLPVD-RIVGGRDTSLGRWPWQVSLRYDG-AHLCGGSLLSGDWVLTAAHCFPE-- 207
           DCG R      R+VGG D   G WPWQVSL   G  H+CG SL+S +W+++AAHC+ +  
Sbjct: 603 DCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDR 662

Query: 208 --RNRVLSRWRVFAGA--VAQASPHGLQ-LGVQAVVYHGGYLPFRDPNSEENSNDIALVH 262
             R    ++W  F G    +Q S  G+Q   ++ ++ H    PF   N      DIAL+ 
Sbjct: 663 GFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISH----PFF--NDFTFDYDIALLE 716

Query: 263 LSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVC 322
           L  P   +  ++P+CLP A      GK   VTGWG+TQY G  A +LQ+  + +I+   C
Sbjct: 717 LEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTC 776

Query: 323 NGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCA 382
              +    QI P+M C G+  GG+D+CQGDSGGP     S+    R    G+VSWG GCA
Sbjct: 777 E--NLLPQQITPRMMCVGFLSGGVDSCQGDSGGPL---SSVEADGRIFQAGVVSWGDGCA 831

Query: 383 LAQKPGVYTKVSDFREWI 400
              KPGVYT++  FR+WI
Sbjct: 832 QRNKPGVYTRLPLFRDWI 849


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  179 bits (455), Expect = 3e-45
 Identities = 114/270 (42%), Positives = 139/270 (51%), Gaps = 21/270 (7%)

Query: 141 PRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLT 200
           P  +  A +   CGRR +   RIVGG D  LGRWPWQ SLR   +H+CG SLLS  W LT
Sbjct: 21  PESQEAAPLSGPCGRRVI-TSRIVGGEDAELGRWPWQGSLRLWDSHVCGVSLLSHRWALT 79

Query: 201 AAHCFPERNRVLSRWRV-FAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENS-NDI 258
           AAHCF       S W V F    +  S   LQ           YL    P    NS  DI
Sbjct: 80  AAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYL---SPRYLGNSPYDI 136

Query: 259 ALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGV-----LQEAR 313
           ALV LS+P+  T++IQP+CL A+     +   C VTGWG   Y  +   +     LQE +
Sbjct: 137 ALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWG---YIKEDEALPSPHTLQEVQ 193

Query: 314 VPIISNDVCNGADF---YGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWR 370
           V II+N +CN       +   I   M CAG  +GG DAC GDSGGP  C    ++   W 
Sbjct: 194 VAIINNSMCNHLFLKYSFRKDIFGDMVCAGNAQGGKDACFGDSGGPLAC----NKNGLWY 249

Query: 371 LCGIVSWGTGCALAQKPGVYTKVSDFREWI 400
             G+VSWG GC    +PGVYT +S   EWI
Sbjct: 250 QIGVVSWGVGCGRPNRPGVYTNISHHFEWI 279


>gi|15559207 elastase 2A preproprotein [Homo sapiens]
          Length = 269

 Score =  178 bits (452), Expect = 7e-45
 Identities = 106/269 (39%), Positives = 145/269 (53%), Gaps = 22/269 (8%)

Query: 146 LAAICQDCGRRKLP--VDRIVGGRDTSLGRWPWQVSLRYDGA----HLCGGSLLSGDWVL 199
           L A    CG    P  V R+VGG +     WPWQVSL+Y       H CGGSL++  WVL
Sbjct: 10  LVAGALSCGDPTYPPYVTRVVGGEEARPNSWPWQVSLQYSSNGKWYHTCGGSLIANSWVL 69

Query: 200 TAAHCFPERNRVLSRWRVFAGA--VAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSND 257
           TAAHC          +RV  G   +  A    L + V  +V H  +    + N     ND
Sbjct: 70  TAAHCISSSRT----YRVGLGRHNLYVAESGSLAVSVSKIVVHKDW----NSNQISKGND 121

Query: 258 IALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPII 317
           IAL+ L++P+ LT+ IQ  CLP AG  L +   C VTGWG  Q  G    VLQ+ R+ ++
Sbjct: 122 IALLKLANPVSLTDKIQLACLPPAGTILPNNYPCYVTGWGRLQTNGAVPDVLQQGRLLVV 181

Query: 318 SNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSW 377
               C+ + ++G+ +K  M CAG  +G I +C GDSGGP  C+ S     RW++ GIVS+
Sbjct: 182 DYATCSSSAWWGSSVKTSMICAG-GDGVISSCNGDSGGPLNCQAS---DGRWQVHGIVSF 237

Query: 378 GT--GCALAQKPGVYTKVSDFREWIFQAI 404
           G+  GC    KP V+T+VS++ +WI   I
Sbjct: 238 GSRLGCNYYHKPSVFTRVSNYIDWINSVI 266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,042,310
Number of Sequences: 37866
Number of extensions: 817221
Number of successful extensions: 2375
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 163
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1639
Number of HSP's gapped (non-prelim): 209
length of query: 417
length of database: 18,247,518
effective HSP length: 105
effective length of query: 312
effective length of database: 14,271,588
effective search space: 4452735456
effective search space used: 4452735456
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.