Search of human proteins with 4503827

Search of human proteins with 4503827

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503827 frizzled 2 [Homo sapiens]
         (565 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503827 frizzled 2 [Homo sapiens]                                 1187   0.0  
gi|4503833 frizzled 7 [Homo sapiens]                                  926   0.0  
gi|4503825 frizzled 1 [Homo sapiens]                                  919   0.0  
gi|27894385 frizzled 5 precursor [Homo sapiens]                       553   e-157
gi|13994190 frizzled 8 [Homo sapiens]                                 527   e-149
gi|6005762 frizzled 10 [Homo sapiens]                                 487   e-137
gi|8393378 frizzled 3 [Homo sapiens]                                  475   e-134
gi|34734079 frizzled 6 [Homo sapiens]                                 461   e-130
gi|4503835 frizzled 9 [Homo sapiens]                                  461   e-129
gi|22547161 frizzled 4 [Homo sapiens]                                 456   e-128
gi|5032099 smoothened [Homo sapiens]                                  174   2e-43
gi|38455388 frizzled-related protein [Homo sapiens]                   125   1e-28
gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]      117   4e-26
gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]       102   9e-22
gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]        101   2e-21
gi|48475052 secreted frizzled-related protein 2 precursor [Homo ...   101   2e-21
gi|29244926 corin [Homo sapiens]                                       97   3e-20
gi|13899255 membrane frizzled-related protein [Homo sapiens]           77   5e-14
gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]      71   3e-12
gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]                70   5e-12
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho...    51   3e-06
gi|139394646 iroquois homeobox protein 5 [Homo sapiens]                36   0.11 
gi|30179900 SRY (sex determining region Y)-box 1 [Homo sapiens]        35   0.14 
gi|154355000 KH-type splicing regulatory protein [Homo sapiens]        35   0.18 
gi|219275578 SIX homeobox 2 [Homo sapiens]                             35   0.18 
gi|93204873 G protein-coupled receptor 157 [Homo sapiens]              35   0.18 
gi|192807323 SWI/SNF-related matrix-associated actin-dependent r...    35   0.24 
gi|192807320 SWI/SNF-related matrix-associated actin-dependent r...    35   0.24 
gi|192807318 SWI/SNF-related matrix-associated actin-dependent r...    35   0.24 
gi|192807316 SWI/SNF-related matrix-associated actin-dependent r...    35   0.24 

>gi|4503827 frizzled 2 [Homo sapiens]
          Length = 565

 Score = 1187 bits (3070), Expect = 0.0
 Identities = 565/565 (100%), Positives = 565/565 (100%)

Query: 1   MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNL 60
           MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNL
Sbjct: 1   MRPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNL 60

Query: 61  LGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQG 120
           LGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQG
Sbjct: 61  LGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQG 120

Query: 121 CEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTP 180
           CEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTP
Sbjct: 121 CEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTP 180

Query: 181 GGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEE 240
           GGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEE
Sbjct: 181 GGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEE 240

Query: 241 TRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVL 300
           TRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVL
Sbjct: 241 TRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVL 300

Query: 301 QERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKW 360
           QERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKW
Sbjct: 301 QERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKW 360

Query: 361 GHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPL 420
           GHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPL
Sbjct: 361 GHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPL 420

Query: 421 FVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACY 480
           FVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACY
Sbjct: 421 FVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACY 480

Query: 481 FYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIW 540
           FYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIW
Sbjct: 481 FYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIW 540

Query: 541 SGKTLHSWRKFYTRLTNSRHGETTV 565
           SGKTLHSWRKFYTRLTNSRHGETTV
Sbjct: 541 SGKTLHSWRKFYTRLTNSRHGETTV 565


>gi|4503833 frizzled 7 [Homo sapiens]
          Length = 574

 Score =  926 bits (2392), Expect = 0.0
 Identities = 448/572 (78%), Positives = 487/572 (85%), Gaps = 15/572 (2%)

Query: 3   PRSALPRLLLPLLLLPA----AGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMP 58
           P S+L    L L LL A    AG   +HGEKGIS+PDHGFCQPISIPLCTDIAYNQTI+P
Sbjct: 9   PLSSLGLCALVLALLGALSAGAGAQPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILP 68

Query: 59  NLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERAR 118
           NLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVL+QAIPPCRS+CERAR
Sbjct: 69  NLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERAR 128

Query: 119 QGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSED-----GAPALLTTAPPPGLQ 173
           QGCEALMNKFGFQWPERLRCE+FP HGA +ICVGQN S+      G P    TAP     
Sbjct: 129 QGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYLPDL 188

Query: 174 PGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGS 233
           P     PG   G G P        PF CPR LKVP YL Y+FLGERDC APCEP R +G 
Sbjct: 189 PFTALPPGASDGRGRPA------FPFSCPRQLKVPPYLGYRFLGERDCGAPCEPGRANGL 242

Query: 234 MFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVA 293
           M+F +EE RFARLW+  WSVLCCAST FTV TYLVDM+RF YPERPIIFLSGCY MV+VA
Sbjct: 243 MYFKEEERRFARLWVGVWSVLCCASTLFTVLTYLVDMRRFSYPERPIIFLSGCYFMVAVA 302

Query: 294 YIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWVILSLTWF 353
           ++AGF+L++R VC ERFS+DGYRTV QGTKKEGCTILFM+LYFF MASSIWWVILSLTWF
Sbjct: 303 HVAGFLLEDRAVCVERFSDDGYRTVAQGTKKEGCTILFMVLYFFGMASSIWWVILSLTWF 362

Query: 354 LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLR 413
           LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQ+DGDLLSGVC+VGL+S+D LR
Sbjct: 363 LAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQVDGDLLSGVCYVGLSSVDALR 422

Query: 414 GFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPA 473
           GFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLE+LMVRIGVFSVLYTVPA
Sbjct: 423 GFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPA 482

Query: 474 TIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGI 533
           TIV+ACYFYEQAFREHWER+W+ Q CKS A+PCP  + P MSPDFTV+MIKYLMT+IVGI
Sbjct: 483 TIVLACYFYEQAFREHWERTWLLQTCKSYAVPCPPGHFPPMSPDFTVFMIKYLMTMIVGI 542

Query: 534 TSGFWIWSGKTLHSWRKFYTRLTNSRHGETTV 565
           T+GFWIWSGKTL SWR+FY RL++S  GET V
Sbjct: 543 TTGFWIWSGKTLQSWRRFYHRLSHSSKGETAV 574


>gi|4503825 frizzled 1 [Homo sapiens]
          Length = 647

 Score =  919 bits (2374), Expect = 0.0
 Identities = 444/552 (80%), Positives = 483/552 (87%), Gaps = 15/552 (2%)

Query: 24  QFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQ 83
           Q++GE+GIS+PDHG+CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQ
Sbjct: 101 QYNGERGISVPDHGYCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQ 160

Query: 84  CSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPR 143
           CS EL+FFLCSMYAPVCTVLEQA+PPCRS+CERARQGCEALMNKFGFQWP+ L+CE FP 
Sbjct: 161 CSAELKFFLCSMYAPVCTVLEQALPPCRSLCERARQGCEALMNKFGFQWPDTLKCEKFPV 220

Query: 144 HGAEQICVGQNHSEDGAP--ALLTTAPPPGLQPGAGGTPGG-PGGGGAPPRYATLEHPFH 200
           HGA ++CVGQN S+ G P  +LL        Q G GG  GG PGG GA  R       F 
Sbjct: 221 HGAGELCVGQNTSDKGTPTPSLLPEFWTSNPQHGGGGHRGGFPGGAGASER-----GKFS 275

Query: 201 CPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTF 260
           CPR LKVPSYL+Y FLGE+DC APCEP +  G M+F  EE RF+R WI  WSVLCCAST 
Sbjct: 276 CPRALKVPSYLNYHFLGEKDCGAPCEPTKVYGLMYFGPEELRFSRTWIGIWSVLCCASTL 335

Query: 261 FTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQ 320
           FTV TYLVDM+RF YPERPIIFLSGCYT V+VAYIAGF+L++RVVCN++F+EDG RTV Q
Sbjct: 336 FTVLTYLVDMRRFSYPERPIIFLSGCYTAVAVAYIAGFLLEDRVVCNDKFAEDGARTVAQ 395

Query: 321 GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVP 380
           GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVP
Sbjct: 396 GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVP 455

Query: 381 AVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFR 440
           A+KTITILA+GQ+DGD+LSGVCFVGLN++D LRGFVLAPLFVYLFIGTSFLLAGFVSLFR
Sbjct: 456 AIKTITILALGQVDGDVLSGVCFVGLNNVDALRGFVLAPLFVYLFIGTSFLLAGFVSLFR 515

Query: 441 IRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCK 500
           IRTIMKHDGTKTEKLE+LMVRIGVFSVLYTVPATIVIACYFYEQAFR+ WERSWV+Q CK
Sbjct: 516 IRTIMKHDGTKTEKLEKLMVRIGVFSVLYTVPATIVIACYFYEQAFRDQWERSWVAQSCK 575

Query: 501 SLAIPCP-------AHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYT 553
           S AIPCP       A   P MSPDFTV+MIKYLMTLIVGITSGFWIWSGKTL+SWRKFYT
Sbjct: 576 SYAIPCPHLQAGGGAPPHPPMSPDFTVFMIKYLMTLIVGITSGFWIWSGKTLNSWRKFYT 635

Query: 554 RLTNSRHGETTV 565
           RLTNS+ GETTV
Sbjct: 636 RLTNSKQGETTV 647


>gi|27894385 frizzled 5 precursor [Homo sapiens]
          Length = 585

 Score =  553 bits (1425), Expect = e-157
 Identities = 291/570 (51%), Positives = 369/570 (64%), Gaps = 53/570 (9%)

Query: 2   RPRSALPRLLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLL 61
           RP  + P  LL LLL    G A    +  +       CQ I++P+C  I YN T MPN  
Sbjct: 3   RPDPSAPPSLLLLLLAQLVGRAAAASKAPV-------CQEITVPMCRGIGYNLTHMPNQF 55

Query: 62  GHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQG 120
            H  Q++AGLEVHQF+PLV++QCSP+LRFFLCSMY P+C     + +PPCRS+CERA+ G
Sbjct: 56  NHDTQDEAGLEVHQFWPLVEIQCSPDLRFFLCSMYTPICLPDYHKPLPPCRSVCERAKAG 115

Query: 121 CEALMNKFGFQWPERLRCEHFPRHG--AEQICVGQNHSEDGAPALLTTAPPPGL--QPGA 176
           C  LM ++GF WPER+ C+  P  G  AE +C+  N SE       TTAPP     +P  
Sbjct: 116 CSPLMRQYGFAWPERMSCDRLPVLGRDAEVLCMDYNRSE------ATTAPPRPFPAKPTL 169

Query: 177 GGTPGGPGGGGAPPRYATLEHPFHCP------RVLKV--PSYLSYKFLGERDCAAPC-EP 227
            G PG P  GG  P       PF C        +LK   P Y   +     +CA PC +P
Sbjct: 170 PGPPGAPASGGECPAGG----PFVCKCREPFVPILKESHPLYNKVRTGQVPNCAVPCYQP 225

Query: 228 ARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCY 287
           +       FS +E  FA  WI  WSVLC  ST  TV T+L+DM+RFRYPERPIIFLS CY
Sbjct: 226 S-------FSADERTFATFWIGLWSVLCFISTSTTVATFLIDMERFRYPERPIIFLSACY 278

Query: 288 TMVSVAYIAGFVL-QERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFFSMASSIWWV 346
             VS+ ++   V+    V C+   +   Y T    T    CTI+F+++YFF MASSIWWV
Sbjct: 279 LCVSLGFLVRLVVGHASVACSREHNHIHYET----TGPALCTIVFLLVYFFGMASSIWWV 334

Query: 347 ILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGL 406
           ILSLTWFLAAGMKWG+EAI   +QYFHLAAW +P+VK+IT LA+  +DGD ++G+C+VG 
Sbjct: 335 ILSLTWFLAAGMKWGNEAIAGYAQYFHLAAWLIPSVKSITALALSSVDGDPVAGICYVGN 394

Query: 407 NSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFS 466
            +L+ LRGFVL PL +YL +GT FLLAGFVSLFRIR+++K  GTKT+KLE+LM+RIG+F+
Sbjct: 395 QNLNSLRGFVLGPLVLYLLVGTLFLLAGFVSLFRIRSVIKQGGTKTDKLEKLMIRIGIFT 454

Query: 467 VLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYT--PRMSPDFTVYMIK 524
           +LYTVPA+IV+ACY YEQ +RE WE         +L   CP H T  PR  P++ V M+K
Sbjct: 455 LLYTVPASIVVACYLYEQHYRESWE--------AALTCACPGHDTGQPRAKPEYWVLMLK 506

Query: 525 YLMTLIVGITSGFWIWSGKTLHSWRKFYTR 554
           Y M L+VGITSG WIWSGKT+ SWR+F +R
Sbjct: 507 YFMCLVVGITSGVWIWSGKTVESWRRFTSR 536


>gi|13994190 frizzled 8 [Homo sapiens]
          Length = 694

 Score =  527 bits (1357), Expect = e-149
 Identities = 295/628 (46%), Positives = 374/628 (59%), Gaps = 103/628 (16%)

Query: 10  LLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDA 69
           LL  L LL  +  A     K ++      CQ I++PLC  I YN T MPN   H  Q++A
Sbjct: 12  LLAALALLQRSSGAAAASAKELA------CQEITVPLCKGIGYNYTYMPNQFNHDTQDEA 65

Query: 70  GLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQGCEALMNKF 128
           GLEVHQF+PLV++QCSP+L+FFLCSMY P+C    ++ +PPCRS+CERA+ GC  LM ++
Sbjct: 66  GLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQY 125

Query: 129 GFQWPERLRCEHFPRHG-AEQICVGQNHSE----DGAPALLTTAPPPGLQPGAG---GTP 180
           GF WP+R+RC+  P  G  + +C+  N ++      +P      PPPG QP +G   G P
Sbjct: 126 GFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRP 185

Query: 181 ---------GGPGGGG----APPRY---------------ATLEHPFHCPRVL------K 206
                    GG GGGG    APP                 A  E    C   +      +
Sbjct: 186 PGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSER 245

Query: 207 VPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTY 266
            P Y   K     +CA PC       + FFSQ+E  F   WI  WSVLC  STF TV+T+
Sbjct: 246 HPLYNRVKTGQIANCALPCH------NPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTF 299

Query: 267 LVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVL-QERVVCNE----------------- 308
           L+DM+RF+YPERPIIFLS CY  VSV Y+   V   E+V C+                  
Sbjct: 300 LIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAG 359

Query: 309 -------------RFSEDGYRTVVQGTKKEG-----CTILFMMLYFFSMASSIWWVILSL 350
                        R   +    V Q  + E      CT++F+++YFF MASSIWWVILSL
Sbjct: 360 AGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSL 419

Query: 351 TWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLD 410
           TWFLAAGMKWG+EAI   SQYFHLAAW VP+VK+I +LA+  +DGD ++G+C+VG  SLD
Sbjct: 420 TWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLD 479

Query: 411 PLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMK-HDG-TKTEKLERLMVRIGVFSVL 468
            LRGFVLAPL +YLFIGT FLLAGFVSLFRIR+++K  DG TKT KLE+LM+R+G+F+VL
Sbjct: 480 NLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVL 539

Query: 469 YTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMS--PDFTVYMIKYL 526
           YTVPA +V+AC FYEQ  R  WE    + +C     PC     P  +  PD+ V+M+KY 
Sbjct: 540 YTVPAAVVVACLFYEQHNRPRWE---ATHNC-----PCLRDLQPDQARRPDYAVFMLKYF 591

Query: 527 MTLIVGITSGFWIWSGKTLHSWRKFYTR 554
           M L+VGITSG W+WSGKTL SWR   TR
Sbjct: 592 MCLVVGITSGVWVWSGKTLESWRSLCTR 619



 Score = 29.6 bits (65), Expect = 7.7
 Identities = 15/24 (62%), Positives = 15/24 (62%), Gaps = 1/24 (4%)

Query: 166 TAPPPGLQPGAGGTPGGPGGGGAP 189
           TA   G  PG GG  GGPGGGG P
Sbjct: 636 TAAGGGGGPGGGGG-GGPGGGGGP 658


>gi|6005762 frizzled 10 [Homo sapiens]
          Length = 581

 Score =  487 bits (1253), Expect = e-137
 Identities = 260/555 (46%), Positives = 343/555 (61%), Gaps = 42/555 (7%)

Query: 15  LLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVH 74
           L+L   G         +  P  G CQPI IP+C DI YN T MPNL+GH NQ +A +++H
Sbjct: 10  LVLQVMGSCAAISSMDMERPGDGKCQPIEIPMCKDIGYNMTRMPNLMGHENQREAAIQLH 69

Query: 75  QFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQGCEALMNKFGFQWP 133
           +F PLV+  C   LRFFLCS+YAP+CT  +   IP CR +CE+AR  C  +M +F F+WP
Sbjct: 70  EFAPLVEYGCHGHLRFFLCSLYAPMCTEQVSTPIPACRVMCEQARLKCSPIMEQFNFKWP 129

Query: 134 ERLRCEHFP-RHGAEQICVGQNHSEDGAPALLTTAPPPGLQP----GAGGTP---GGPGG 185
           + L C   P ++    +C+   ++    P   +   PP  +P     A   P   GGPG 
Sbjct: 130 DSLDCRKLPNKNDPNYLCMEAPNNGSDEPTRGSGLFPPLFRPQRPHSAQEHPLKDGGPGR 189

Query: 186 GGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFAR 245
           GG        ++P     V K  S           CA  C P      +++S+E+ RFA 
Sbjct: 190 GGC-------DNPGKFHHVEKSAS-----------CAPLCTPGV---DVYWSREDKRFAV 228

Query: 246 LWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAG-FVLQERV 304
           +W+  W+VLC  S+ FTV T+L+D  RFRYPERPIIFLS CY + SV Y+   F   E +
Sbjct: 229 VWLAIWAVLCFFSSAFTVLTFLIDPARFRYPERPIIFLSMCYCVYSVGYLIRLFAGAESI 288

Query: 305 VCNERFSEDGYRTVVQ-GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHE 363
            C+    + G   V+Q G +  GCT++F++LY+F MASS+WWV+L+LTWFLAAG KWGHE
Sbjct: 289 ACDR---DSGQLYVIQEGLESTGCTLVFLVLYYFGMASSLWWVVLTLTWFLAAGKKWGHE 345

Query: 364 AIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVY 423
           AIEANS YFHLAAWA+PAVKTI IL M ++ GD L+GVC+VG   ++ L GFVL PL  Y
Sbjct: 346 AIEANSSYFHLAAWAIPAVKTILILVMRRVAGDELTGVCYVGSMDVNALTGFVLIPLACY 405

Query: 424 LFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYE 483
           L IGTSF+L+GFV+LF IR +MK  G  T+KLE+LMVRIG+FSVLYTVPAT VIACYFYE
Sbjct: 406 LVIGTSFILSGFVALFHIRRVMKTGGENTDKLEKLMVRIGLFSVLYTVPATCVIACYFYE 465

Query: 484 QAFREHWERSWVSQHCK----SLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWI 539
           +   ++W+       CK    +  + C         P   ++M+K  M L+VGITSG WI
Sbjct: 466 RLNMDYWKILAAQHKCKMNNQTKTLDC---LMAASIPAVEIFMVKIFMLLVVGITSGMWI 522

Query: 540 WSGKTLHSWRKFYTR 554
           W+ KTL SW++  +R
Sbjct: 523 WTSKTLQSWQQVCSR 537


>gi|8393378 frizzled 3 [Homo sapiens]
          Length = 666

 Score =  475 bits (1223), Expect = e-134
 Identities = 233/515 (45%), Positives = 317/515 (61%), Gaps = 32/515 (6%)

Query: 39  CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98
           C+PI++ +C D+ YN T MPNLL H +Q+ A L +  F+P+V + CS + R FLC++YAP
Sbjct: 28  CEPITLRMCQDLPYNTTFMPNLLNHYDQQTAALAMEPFHPMVNLDCSRDFRPFLCALYAP 87

Query: 99  VCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSED 158
           +C    +   PCR +C+RA   C  LM  FG  WPE + C  FP              ++
Sbjct: 88  ICMEYGRVTLPCRRLCQRAYSECSKLMEMFGVPWPEDMECSRFP------------DCDE 135

Query: 159 GAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGE 218
             P L+                G P  G   P     ++ F CPR LK+   L Y FL  
Sbjct: 136 PYPRLVDL-----------NLAGEPTEGA--PVAVQRDYGFWCPRELKIDPDLGYSFLHV 182

Query: 219 RDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPER 278
           RDC+ PC       +M+F +EE  FAR +I   S++C ++T FT  T+L+D+ RFRYPER
Sbjct: 183 RDCSPPCP------NMYFRREELSFARYFIGLISIICLSATLFTFLTFLIDVTRFRYPER 236

Query: 279 PIIFLSGCYTMVSVAYIAGFVLQERVVCNERF-SEDGYRTVVQGTKKEGCTILFMMLYFF 337
           PIIF + CY MVS+ +  GF+L++RV CN    ++    TV QG+  + CT+LFM+LYFF
Sbjct: 237 PIIFYAVCYMMVSLIFFIGFLLEDRVACNASIPAQYKASTVTQGSHNKACTMLFMILYFF 296

Query: 338 SMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDL 397
           +MA S+WWVIL++TWFLAA  KWG EAIE  +  FH +AW +P   TI +LAM +I+GD 
Sbjct: 297 TMAGSVWWVILTITWFLAAVPKWGSEAIEKKALLFHASAWGIPGTLTIILLAMNKIEGDN 356

Query: 398 LSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLER 457
           +SGVCFVGL  +D LR FVLAPL +Y+ +G S LLAG +SL R+R  +  +    +KL +
Sbjct: 357 ISGVCFVGLYDVDALRYFVLAPLCLYVVVGVSLLLAGIISLNRVRIEIPLEKENQDKLVK 416

Query: 458 LMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPD 517
            M+RIGVFS+LY VP  +VI CYFYEQA+R  WE +W+ + C+   IPCP   T    PD
Sbjct: 417 FMIRIGVFSILYLVPLLVVIGCYFYEQAYRGIWETTWIQERCREYHIPCPYQVTQMSRPD 476

Query: 518 FTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFY 552
             ++++KYLM LIVGI S FW+ S KT   W  F+
Sbjct: 477 LILFLMKYLMALIVGIPSVFWVGSKKTCFEWASFF 511


>gi|34734079 frizzled 6 [Homo sapiens]
          Length = 706

 Score =  461 bits (1187), Expect = e-130
 Identities = 225/517 (43%), Positives = 308/517 (59%), Gaps = 32/517 (6%)

Query: 39  CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98
           C+PI++P C  +AYN T  PNL+GH +Q  A +E+  F PL  ++CSP +  FLC  + P
Sbjct: 24  CEPITVPRCMKMAYNMTFFPNLMGHYDQSIAAVEMEHFLPLANLECSPNIETFLCKAFVP 83

Query: 99  VCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSED 158
            C      +PPCR +CE+    C+ L++ FG +WPE L C+               H+E 
Sbjct: 84  TCIEQIHVVPPCRKLCEKVYSDCKKLIDTFGIRWPEELECDRLQYCDETVPVTFDPHTEF 143

Query: 159 GAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGE 218
             P   T      +Q   G                     F CPR LK      YKFLG 
Sbjct: 144 LGPQKKTEQ----VQRDIG---------------------FWCPRHLKTSGGQGYKFLGI 178

Query: 219 RDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPER 278
             CA PC       +M+F  +E  FA+ +I T S+ C  +T FT  T+L+D++RFRYPER
Sbjct: 179 DQCAPPCP------NMYFKSDELEFAKSFIGTVSIFCLCATLFTFLTFLIDVRRFRYPER 232

Query: 279 PIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSE-DGYRTVVQGTKKEGCTILFMMLYFF 337
           PII+ S CY++VS+ Y  GF+L +   CN+   + +   TVV G++ + CT+LFM+LYFF
Sbjct: 233 PIIYYSVCYSIVSLMYFIGFLLGDSTACNKADEKLELGDTVVLGSQNKACTVLFMLLYFF 292

Query: 338 SMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDL 397
           +MA ++WWVIL++TWFLAAG KW  EAIE  + +FH  AW  P   T+ +LAM +++GD 
Sbjct: 293 TMAGTVWWVILTITWFLAAGRKWSCEAIEQKAVWFHAVAWGTPGFLTVMLLAMNKVEGDN 352

Query: 398 LSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLER 457
           +SGVCFVGL  LD  R FVL PL + +F+G S LLAG +SL  +R +++HDG   EKL++
Sbjct: 353 ISGVCFVGLYDLDASRYFVLLPLCLCVFVGLSLLLAGIISLNHVRQVIQHDGRNQEKLKK 412

Query: 458 LMVRIGVFSVLYTVPATIVIACYFYEQAFREHWERSWVSQHCKSLAIPCPAHYTPRMSPD 517
            M+RIGVFS LY VP   ++ CY YEQ  R  WE +WVS HC+   IPCP     +  P+
Sbjct: 413 FMIRIGVFSGLYLVPLVTLLGCYVYEQVNRITWEITWVSDHCRQYHIPCPYQAKAKARPE 472

Query: 518 FTVYMIKYLMTLIVGITSGFWIWSGKTLHSWRKFYTR 554
             ++MIKYLMTLIVGI++ FW+ S KT   W  F+ R
Sbjct: 473 LALFMIKYLMTLIVGISAVFWVGSKKTCTEWAGFFKR 509


>gi|4503835 frizzled 9 [Homo sapiens]
          Length = 591

 Score =  461 bits (1185), Expect = e-129
 Identities = 256/562 (45%), Positives = 333/562 (59%), Gaps = 46/562 (8%)

Query: 11  LLPLLLLPAAGPA----QFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQ 66
           LL   LL A G A    +F  E+G        CQ + IP+C  I YN T MPNLLGHT+Q
Sbjct: 10  LLLWQLLAAGGAALEIGRFDPERGRGAAP---CQAVEIPMCRGIGYNLTRMPNLLGHTSQ 66

Query: 67  EDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCT-VLEQAIPPCRSICERARQGCEALM 125
            +A  E+ +F PLV+  C   LRFFLCS+YAP+CT  +   IP CR +CE+AR  C  +M
Sbjct: 67  GEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIM 126

Query: 126 NKFGFQWPERLRCEHFP-RHGAEQICVGQNHSEDGAPA-------LLTTAPPPGLQPGAG 177
            +F F WP+ L C   P R+    +C+    +    PA       +L  AP P   PG  
Sbjct: 127 EQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPG-- 184

Query: 178 GTPGGPGGGGAPPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFS 237
               GPG GG+     T E+P     V K            R CA  C P      +F+S
Sbjct: 185 --DLGPGAGGS----GTCENPEKFQYVEK-----------SRSCAPRCGPGV---EVFWS 224

Query: 238 QEETRFARLWILTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAG 297
           + +  FA +W+  WS LC  ST FTV T+L++  RF+YPERPIIFLS CY + S+A++  
Sbjct: 225 RRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIR 284

Query: 298 FVL-QERVVCNERFSEDGYRTVVQ-GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLA 355
            V   + V C++   E G   V+Q G +  GCT++F++LY+F MASS+WWV+L+LTWFLA
Sbjct: 285 AVAGAQSVACDQ---EAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLA 341

Query: 356 AGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGF 415
           AG KWGHEAIEA+  YFH+AAW +PA+KTI IL + ++ GD L+G+C+V       L GF
Sbjct: 342 AGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGF 401

Query: 416 VLAPLFVYLFIGTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATI 475
           VL PL  YL +G+SFLL GFV+LF IR IMK  GT TEKLE+LMV+IGVFS+LYTVPAT 
Sbjct: 402 VLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATC 461

Query: 476 VIACYFYEQAFREHWERSWVSQHCKSLAIP---CPAHYTPRMSPDFTVYMIKYLMTLIVG 532
           VI CY YE+   + W      Q C + A P             P   V+M+K  M+L+VG
Sbjct: 462 VIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVG 521

Query: 533 ITSGFWIWSGKTLHSWRKFYTR 554
           ITSG W+WS KT  +W+    R
Sbjct: 522 ITSGVWVWSSKTFQTWQSLCYR 543


>gi|22547161 frizzled 4 [Homo sapiens]
          Length = 537

 Score =  456 bits (1173), Expect = e-128
 Identities = 253/552 (45%), Positives = 332/552 (60%), Gaps = 63/552 (11%)

Query: 10  LLLPLLLLPAAGPAQFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDA 69
           LLL LLLL   GPA+  G++     +   C PI I +C ++ YN T MPNL+GH  Q DA
Sbjct: 23  LLLQLLLL--LGPARGFGDE-----EERRCDPIRISMCQNLGYNVTKMPNLVGHELQTDA 75

Query: 70  GLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTV-LEQAIPPCRSICERARQGCEALMNKF 128
            L++  F PL++  CS +L+FFLCS+Y P+CT  +   I PC  +C   ++ CE ++ +F
Sbjct: 76  ELQLTTFTPLIQYGCSSQLQFFLCSVYVPMCTEKINIPIGPCGGMCLSVKRRCEPVLKEF 135

Query: 129 GFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGA 188
           GF WPE L C  FP          +   ++  P    T   PG +  + GT         
Sbjct: 136 GFAWPESLNCSKFPPQNDHNHMCMEGPGDEEVPLPHKTPIQPGEECHSVGTNSD------ 189

Query: 189 PPRYATLEHPFHCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWI 248
             +Y  ++   +C  VLK              C              +S+    F  +W+
Sbjct: 190 --QYIWVKRSLNC--VLK--------------CGYDAG--------LYSRSAKEFTDIWM 223

Query: 249 LTWSVLCCASTFFTVTTYLVDMQRFRYPERPIIFLSGCYTMVSVAYIAGFVL-QERVVCN 307
             W+ LC  ST FTV T+L+D  RF YPERPIIFLS CY + S+AYI    + +ER+ C+
Sbjct: 224 AVWASLCFISTAFTVLTFLIDSSRFSYPERPIIFLSMCYNIYSIAYIVRLTVGRERISCD 283

Query: 308 ERFSEDGYRTVVQ-GTKKEGCTILFMMLYFFSMASSIWWVILSLTWFLAAGMKWGHEAIE 366
             F E     ++Q G K  GC I+F+++YFF MASSIWWVIL+LTWFLAAG+KWGHEAIE
Sbjct: 284 --FEEAAEPVLIQEGLKNTGCAIIFLLMYFFGMASSIWWVILTLTWFLAAGLKWGHEAIE 341

Query: 367 ANSQYFHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFI 426
            +S YFH+AAWA+PAVKTI IL M  +D D L+G+C+VG  +LD L GFV+APLF YL I
Sbjct: 342 MHSSYFHIAAWAIPAVKTIVILIMRLVDADELTGLCYVGNQNLDALTGFVVAPLFTYLVI 401

Query: 427 GTSFLLAGFVSLFRIRTIMKHDGTKTEKLERLMVRIGVFSVLYTVPATIVIACYFYEQAF 486
           GT F+ AG V+LF+IR+ ++ DGTKT+KLERLMV+IGVFSVLYTVPAT VIACYFYE + 
Sbjct: 402 GTLFIAAGLVALFKIRSNLQKDGTKTDKLERLMVKIGVFSVLYTVPATCVIACYFYEIS- 460

Query: 487 REHWERSWVSQHCKSLAIPCPAHYTPRMSPDFTVYMIKYLMTLIVGITSGFWIWSGKTLH 546
             +W     S    ++A                V M+K  M+L+VGITSG WIWS KTLH
Sbjct: 461 --NWALFRYSADDSNMA----------------VEMLKIFMSLLVGITSGMWIWSAKTLH 502

Query: 547 SWRKFYTRLTNS 558
           +W+K   RL NS
Sbjct: 503 TWQKCSNRLVNS 514


>gi|5032099 smoothened [Homo sapiens]
          Length = 787

 Score =  174 bits (441), Expect = 2e-43
 Identities = 130/502 (25%), Positives = 222/502 (44%), Gaps = 81/502 (16%)

Query: 83  QCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRC--EH 140
           +C   ++  LC++Y P C   ++   P R++C+  R  C  +  + G  WP+ LRC  + 
Sbjct: 117 RCWAVIQPLLCAVYMPKCEN-DRVELPSRTLCQATRGPCAIVERERG--WPDFLRCTPDR 173

Query: 141 FPRHGAEQIC-VGQNHSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPF 199
           FP     ++  +  N S      L+ T  P        G                     
Sbjct: 174 FPEGCTNEVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEG--------------------- 212

Query: 200 HCPRVLKVPSYLSYKFLGERDCAAPCEPARPDGSMFFSQEETRFARLWILTWSVLCCAST 259
                                C   C+      +  F++ E +    +I  +  +    T
Sbjct: 213 ---------------------CGIQCQ------NPLFTEAEHQDMHSYIAAFGAVTGLCT 245

Query: 260 FFTVTTYLVDMQRF-RYPERPIIFLSGCYTMVSVAYIAGFV--LQERVVCNERFSEDGYR 316
            FT+ T++ D +   RYP   + +++ C+ + S+ ++A F+   +  +VC      DG  
Sbjct: 246 LFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRA----DGTM 301

Query: 317 TVVQGTKKE--GCTILFMMLYFFSMASSIWWVILSLTW---FLAAGMKWGHEAIEANSQY 371
            + + T  E   C I+F+++Y+  MA  +W+V+L+  W   F A G  +  + +   + Y
Sbjct: 302 RLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTY--QPLSGKTSY 359

Query: 372 FHLAAWAVPAVKTITILAMGQIDGDLLSGVCFVGLNSLDPLRGFVLAPLFVYLFIGTSFL 431
           FHL  W++P V T+ ILA+ Q+DGD +SG+CFVG  +     GFVLAP+ + L +G  FL
Sbjct: 360 FHLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFL 419

Query: 432 LAGFVSLFRIRTIMKHDGTKTE----KLERLMVRIGVFSVLYTVPATIVIACYFYEQAFR 487
           + G ++LF I++   H G  +E    K+   M+R+G+F  L      I  +C+FY+   +
Sbjct: 420 IRGVMTLFSIKS--NHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQ 477

Query: 488 EHWERSW----VSQHCKSLAIPCPAHYTP---RMSPDFTVYMIKYLMTLIVGITSGFWIW 540
             WERS+    + Q   ++ +P          +  P   V  I        GI    W+W
Sbjct: 478 AEWERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVW 537

Query: 541 SGKTLHSWRKFYTRLTNSRHGE 562
           +  TL  WR+ + RLT     E
Sbjct: 538 TKATLLIWRRTWCRLTGQSDDE 559


>gi|38455388 frizzled-related protein [Homo sapiens]
          Length = 325

 Score =  125 bits (313), Expect = 1e-28
 Identities = 54/106 (50%), Positives = 72/106 (67%), Gaps = 2/106 (1%)

Query: 39  CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98
           C+P+ IPLC  + +N T MPN L H+ Q +A L + QF  L+   CSP+L FFLC+MYAP
Sbjct: 35  CEPVRIPLCKSLPWNMTKMPNHLHHSTQANAILAIEQFEGLLGTHCSPDLLFFLCAMYAP 94

Query: 99  VCTV--LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFP 142
           +CT+    + I PC+S+CERARQGCE ++ K+   WPE L CE  P
Sbjct: 95  ICTIDFQHEPIKPCKSVCERARQGCEPILIKYRHSWPENLACEELP 140


>gi|170784838 secreted frizzled-related  protein 4 [Homo sapiens]
          Length = 346

 Score =  117 bits (292), Expect = 4e-26
 Identities = 52/106 (49%), Positives = 69/106 (65%), Gaps = 2/106 (1%)

Query: 39  CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98
           C+ + IP+C  + +N T MPN L H+ QE+A L + Q+  LV V CS  LRFFLC+MYAP
Sbjct: 24  CEAVRIPMCRHMPWNITRMPNHLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAP 83

Query: 99  VCTV--LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFP 142
           +CT+  L   I PC+S+C+RAR  CE LM  +   WPE L C+  P
Sbjct: 84  ICTLEFLHDPIKPCKSVCQRARDDCEPLMKMYNHSWPESLACDELP 129


>gi|188528609 secreted frizzled-related protein 5 [Homo sapiens]
          Length = 317

 Score =  102 bits (254), Expect = 9e-22
 Identities = 55/144 (38%), Positives = 74/144 (51%), Gaps = 10/144 (6%)

Query: 26  HGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCS 85
           HG +  S P      P  +PLC  + Y +  +PNLL H +  +   +   + PL+  +C 
Sbjct: 43  HG-RSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCH 101

Query: 86  PELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHG 145
            + + FLCS++APVC  L++ I PCRS+CE  R GC  LM  +GF WPE L C  FP   
Sbjct: 102 SDTQVFLCSLFAPVC--LDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDN 159

Query: 146 AEQICVGQNHSEDGAPALLTTAPP 169
              I V   H       L  TAPP
Sbjct: 160 DLCIAVQFGH-------LPATAPP 176


>gi|56117838 secreted frizzled-related protein 1 [Homo sapiens]
          Length = 314

 Score =  101 bits (251), Expect = 2e-21
 Identities = 47/129 (36%), Positives = 67/129 (51%), Gaps = 2/129 (1%)

Query: 41  PISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVC 100
           P  + LC ++ Y + ++PNLL H    +   +   + PL+   C    + FLCS++APVC
Sbjct: 62  PADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLNKNCHAGTQVFLCSLFAPVC 121

Query: 101 TVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGA 160
             L++ I PCR +CE  R  CE +M  FGF WPE L+C+ FP           N +E   
Sbjct: 122 --LDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKFPEGDVCIAMTPPNATEASK 179

Query: 161 PALLTTAPP 169
           P   T  PP
Sbjct: 180 PQGTTVCPP 188


>gi|48475052 secreted frizzled-related protein 2 precursor [Homo
           sapiens]
          Length = 295

 Score =  101 bits (251), Expect = 2e-21
 Identities = 56/159 (35%), Positives = 85/159 (53%), Gaps = 12/159 (7%)

Query: 14  LLLLPAAGPAQFHGEKGISI---PDHGF----CQPI--SIPLCTDIAYNQTIMPNLLGHT 64
           LLLL  A        +G+ +   PD  +    C+PI  ++ LC  I Y    +PNLLGH 
Sbjct: 8   LLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIPANLQLCHGIEYQNMRLPNLLGHE 67

Query: 65  NQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVC-TVLEQAIPPCRSICERARQGCEA 123
             ++   +   + PLV  QC P+ + FLCS++APVC   L++ I PC S+C + +  C  
Sbjct: 68  TMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPVCLDDLDETIQPCHSLCVQVKDRCAP 127

Query: 124 LMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPA 162
           +M+ FGF WP+ L C+ FP+     +C+    S+   PA
Sbjct: 128 VMSAFGFPWPDMLECDRFPQD--NDLCIPLASSDHLLPA 164


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 45/117 (38%), Positives = 68/117 (58%), Gaps = 4/117 (3%)

Query: 39  CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGL--EVHQFYPLVKVQCSPELRFFLCSMY 96
           C+PI++ LC ++ YN T  PN  GH  Q++A +  E   F  LV+  C   L FF C++ 
Sbjct: 455 CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNCYKYLMFFSCTIL 514

Query: 97  APVCTV-LEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAE-QICV 151
            P C V   + IPPCR++CE +++ CE+++   G QWPE   C  FP   ++ Q C+
Sbjct: 515 VPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENSDNQTCL 571



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 4/106 (3%)

Query: 39  CQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAP 98
           C  I+   C  + Y+ T+ P L    N E     +  F  L ++ C   +  F C++  P
Sbjct: 139 CMNITHSQCQMLPYHATLTPLLSVVRNMEMEKF-LKFFTYLHRLSCYQHIMLFGCTLAFP 197

Query: 99  VCTVL---EQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHF 141
            C +       + PCRS CE A++GCE+++    + WP+ LRC  F
Sbjct: 198 ECIIDGDDSHGLLPCRSFCEAAKEGCESVLGMVNYSWPDFLRCSQF 243


>gi|13899255 membrane frizzled-related protein [Homo sapiens]
          Length = 579

 Score = 76.6 bits (187), Expect = 5e-14
 Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 3/113 (2%)

Query: 39  CQPISIPLCTDIAYNQTIMPNL-LGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYA 97
           C+P+ + +C  ++YN T  PN+ +G   QE+    +  +  L  + C    R  LC +  
Sbjct: 466 CEPVQVEMCLGLSYNTTAFPNIWVGMITQEEVVEVLSGYKSLTSLPCYQHFRRLLCGLLV 525

Query: 98  PVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQIC 150
           P CT L   +PPCRS+C+ A   C++ +   G  WP    C   P     + C
Sbjct: 526 PRCTPLGSVLPPCRSVCQEAEHQCQSGLALLGTPWP--FNCNRLPEAADLEAC 576


>gi|62388875 carboxypeptidase Z isoform 2 precursor [Homo sapiens]
          Length = 641

 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 46/140 (32%), Positives = 68/140 (48%), Gaps = 13/140 (9%)

Query: 8   PRLLLPLLLLPAAGPA-QFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQ 66
           P LLL +L++ AA P  +F      +      C  + +  C+D AYN T  PNLL H + 
Sbjct: 6   PLLLLTVLVVAAARPGCEFERNPAAT------CVDLQLRTCSDAAYNHTTFPNLLQHRSW 59

Query: 67  E--DAGLE---VHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGC 121
           E  +A  E   +   + L++ QC+P+LR   C++ AP C        PCR ICE  R+ C
Sbjct: 60  EVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEG-GWVRRPCRHICEGLREVC 118

Query: 122 EALMNKFGFQWPERLRCEHF 141
           +   +     WP  L C  +
Sbjct: 119 QPAFDAIDMAWPYFLDCHRY 138


>gi|62388877 carboxypeptidase Z isoform 1 [Homo sapiens]
          Length = 652

 Score = 70.1 bits (170), Expect = 5e-12
 Identities = 47/145 (32%), Positives = 68/145 (46%), Gaps = 12/145 (8%)

Query: 8   PRLLLPLLLLPAAGPA-QFHGEKGISI-----PDHGFCQPISIPLCTDIAYNQTIMPNLL 61
           P LLL +L++ AA P  +F              D   C  + +  C+D AYN T  PNLL
Sbjct: 6   PLLLLTVLVVAAARPGCEFERNPAGECHRPPAADSATCVDLQLRTCSDAAYNHTTFPNLL 65

Query: 62  GHTNQE--DAGLE---VHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICER 116
            H + E  +A  E   +   + L++ QC+P+LR   C++ AP C        PCR ICE 
Sbjct: 66  QHRSWEVVEASSEYILLSVLHQLLEGQCNPDLRLLGCAVLAPRCEG-GWVRRPCRHICEG 124

Query: 117 ARQGCEALMNKFGFQWPERLRCEHF 141
            R+ C+   +     WP  L C  +
Sbjct: 125 LREVCQPAFDAIDMAWPYFLDCHRY 149


>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
           sapiens]
          Length = 1751

 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 27/88 (30%), Positives = 42/88 (47%), Gaps = 3/88 (3%)

Query: 37  GFCQPI--SIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCS 94
           G C P+  S+P+C  +  ++  +PN L H + E        +  L++  C P L +F C 
Sbjct: 332 GRCLPLPPSLPVCGHLGISRFWLPNHLHHESGEQVRAGARAWGGLLQTHCHPFLAWFFCL 391

Query: 95  MYAPVC-TVLEQAIPPCRSICERARQGC 121
           +  P C +V   A PPC   CE  +  C
Sbjct: 392 LLVPPCGSVPPPAPPPCCQFCEALQDAC 419



 Score = 30.8 bits (68), Expect = 3.5
 Identities = 20/44 (45%), Positives = 21/44 (47%), Gaps = 5/44 (11%)

Query: 152 GQNHSEDGAPALLTTAP----PPGLQPGAGGTPGGPGGGGAPPR 191
           G N S+   PA L   P    PPG  PG  G PG PG  G P R
Sbjct: 924 GVNSSDVPGPAGLPGVPGREGPPGF-PGLPGPPGPPGREGPPGR 966


>gi|139394646 iroquois homeobox protein 5 [Homo sapiens]
          Length = 483

 Score = 35.8 bits (81), Expect = 0.11
 Identities = 21/49 (42%), Positives = 22/49 (44%), Gaps = 6/49 (12%)

Query: 156 SEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGA------PPRYATLEHP 198
           +ED AP     AP PG  P AG  P GPGG         PP  A L  P
Sbjct: 284 AEDPAPHYPAGAPAPGPHPAAGEVPPGPGGPSVIHSPPPPPPPAVLAKP 332


>gi|30179900 SRY (sex determining region Y)-box 1 [Homo sapiens]
          Length = 391

 Score = 35.4 bits (80), Expect = 0.14
 Identities = 18/46 (39%), Positives = 22/46 (47%)

Query: 155 HSEDGAPALLTTAPPPGLQPGAGGTPGGPGGGGAPPRYATLEHPFH 200
           HS  GA A    + P G   G GG  GG GGGGA      ++ P +
Sbjct: 11  HSPGGAQAPTNLSGPAGAGGGGGGGGGGGGGGGAKANQDRVKRPMN 56


>gi|154355000 KH-type splicing regulatory protein [Homo sapiens]
          Length = 711

 Score = 35.0 bits (79), Expect = 0.18
 Identities = 15/26 (57%), Positives = 15/26 (57%)

Query: 165 TTAPPPGLQPGAGGTPGGPGGGGAPP 190
           T  PPPG  P AGG  G  G GG PP
Sbjct: 6   TGGPPPGPPPPAGGGGGAGGAGGGPP 31



 Score = 30.0 bits (66), Expect = 5.9
 Identities = 14/22 (63%), Positives = 14/22 (63%), Gaps = 1/22 (4%)

Query: 168 PPPGLQPGAGGTPGGPGGGGAP 189
           PPPG  PGAG   GG  GGG P
Sbjct: 30  PPPG-PPGAGDRGGGGPGGGGP 50


>gi|219275578 SIX homeobox 2 [Homo sapiens]
          Length = 291

 Score = 35.0 bits (79), Expect = 0.18
 Identities = 24/70 (34%), Positives = 31/70 (44%), Gaps = 19/70 (27%)

Query: 140 HFPRHGAEQICVGQNHSE----------DGAPALLTTAPPPGL--------QPGAGGTP- 180
           H P +G+ +  +G +  E            +PALL + PPPGL         PG    P 
Sbjct: 198 HNPLNGSGKSVLGSSEDEKTPSGTPDHSSSSPALLLSPPPPGLPSLHSLGHPPGPSAVPV 257

Query: 181 GGPGGGGAPP 190
             PGGGGA P
Sbjct: 258 PVPGGGGADP 267


>gi|93204873 G protein-coupled receptor 157 [Homo sapiens]
          Length = 335

 Score = 35.0 bits (79), Expect = 0.18
 Identities = 34/162 (20%), Positives = 68/162 (41%), Gaps = 25/162 (15%)

Query: 278 RPIIFLSGCYTMVSVAYIAGFVLQERVVCNERFSEDGYRTVVQGTKKEGCTILFMMLYFF 337
           R ++FLS    + + +Y  G +        + F+   +  V+QG           +  F 
Sbjct: 48  RLLLFLSLADLLSAASYFYGVL--------QNFAGPSWDCVLQGA----------LSTFA 89

Query: 338 SMASSIWWVILSLTWFLAAGMKWGHEAIEANSQYFHLAAWAVPAVKTITILAMGQID--- 394
           + +S  W V ++L  +L+          +     FH+ +W VP V T+  +A+ +I    
Sbjct: 90  NTSSFFWTVAIALYLYLSIVRAARGPRTDRLLWAFHVVSWGVPLVITVAAVALKKIGYDA 149

Query: 395 GDLLSGVCFVGLNSLDPLRGFVLA----PLFVYLFIGTSFLL 432
            D+  G C++ L + D +   +L      +  Y+ +   +LL
Sbjct: 150 SDVSVGWCWIDLEAKDHVLWMLLTGKLWEMLAYVLLPLLYLL 191


>gi|192807323 SWI/SNF-related matrix-associated actin-dependent
           regulator of chromatin a4 isoform A [Homo sapiens]
          Length = 1679

 Score = 34.7 bits (78), Expect = 0.24
 Identities = 20/50 (40%), Positives = 24/50 (48%), Gaps = 4/50 (8%)

Query: 148 QICVGQNHSEDGAPALLTTAPPPGLQ---PGAGGTPG-GPGGGGAPPRYA 193
           Q+ V       G    + T PPP +    PG G  PG GPG G APP Y+
Sbjct: 201 QMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYS 250


>gi|192807320 SWI/SNF-related matrix-associated actin-dependent
           regulator of chromatin a4 isoform F [Homo sapiens]
          Length = 1613

 Score = 34.7 bits (78), Expect = 0.24
 Identities = 20/50 (40%), Positives = 24/50 (48%), Gaps = 4/50 (8%)

Query: 148 QICVGQNHSEDGAPALLTTAPPPGLQ---PGAGGTPG-GPGGGGAPPRYA 193
           Q+ V       G    + T PPP +    PG G  PG GPG G APP Y+
Sbjct: 201 QMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYS 250


>gi|192807318 SWI/SNF-related matrix-associated actin-dependent
           regulator of chromatin a4 isoform E [Homo sapiens]
          Length = 1614

 Score = 34.7 bits (78), Expect = 0.24
 Identities = 20/50 (40%), Positives = 24/50 (48%), Gaps = 4/50 (8%)

Query: 148 QICVGQNHSEDGAPALLTTAPPPGLQ---PGAGGTPG-GPGGGGAPPRYA 193
           Q+ V       G    + T PPP +    PG G  PG GPG G APP Y+
Sbjct: 201 QMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYS 250


>gi|192807316 SWI/SNF-related matrix-associated actin-dependent
           regulator of chromatin a4 isoform D [Homo sapiens]
          Length = 1616

 Score = 34.7 bits (78), Expect = 0.24
 Identities = 20/50 (40%), Positives = 24/50 (48%), Gaps = 4/50 (8%)

Query: 148 QICVGQNHSEDGAPALLTTAPPPGLQ---PGAGGTPG-GPGGGGAPPRYA 193
           Q+ V       G    + T PPP +    PG G  PG GPG G APP Y+
Sbjct: 201 QMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGPGPGPAPPNYS 250


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.327    0.141    0.467 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,864,039
Number of Sequences: 37866
Number of extensions: 1318545
Number of successful extensions: 12153
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 51
Number of HSP's successfully gapped in prelim test: 92
Number of HSP's that attempted gapping in prelim test: 10304
Number of HSP's gapped (non-prelim): 1859
length of query: 565
length of database: 18,247,518
effective HSP length: 108
effective length of query: 457
effective length of database: 14,157,990
effective search space: 6470201430
effective search space used: 6470201430
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.