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Search of human proteins with 4503817
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
(332 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo sa... 645 0.0
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s... 92 5e-19
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo... 91 1e-18
gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Hom... 86 6e-17
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens] 84 1e-16
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens] 82 9e-16
gi|40254992 carbonic reductase 4 [Homo sapiens] 81 1e-15
gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens] 79 7e-15
gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 76 5e-14
gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens] 76 5e-14
gi|25282469 retinol dehydrogenase 10 [Homo sapiens] 73 4e-13
gi|166795268 retinol dehydrogenase 11 [Homo sapiens] 70 3e-12
gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1 [... 70 3e-12
gi|223646115 short chain dehydrogenase/reductase family 16C, mem... 69 6e-12
gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens] 69 6e-12
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo... 68 1e-11
gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2 ... 68 1e-11
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ... 67 2e-11
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens] 67 2e-11
gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 67 3e-11
gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 67 3e-11
gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [H... 67 3e-11
gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens] 67 3e-11
gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapi... 65 6e-11
gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Ho... 65 6e-11
gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens] 65 8e-11
gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Ho... 65 1e-10
gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo sapi... 64 1e-10
gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo sap... 64 1e-10
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens] 64 2e-10
>gi|4503817 3-ketodihydrosphingosine reductase precursor [Homo
sapiens]
Length = 332
Score = 645 bits (1663), Expect = 0.0
Identities = 332/332 (100%), Positives = 332/332 (100%)
Query: 1 MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFIT 60
MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFIT
Sbjct: 1 MLLLAAAFLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFIT 60
Query: 61 LVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVN 120
LVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVN
Sbjct: 61 LVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVN 120
Query: 121 CAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGL 180
CAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGL
Sbjct: 121 CAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGL 180
Query: 181 FGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISE 240
FGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISE
Sbjct: 181 FGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISE 240
Query: 241 TTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLF 300
TTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLF
Sbjct: 241 TTSVCKPEQVAKQIVKDAIQGNFNSSLGSDGYMLSALTCGMAPVTSITEGLQQVVTMGLF 300
Query: 301 RTIALFYLGSFDSIVRRCMMQREKSENADKTA 332
RTIALFYLGSFDSIVRRCMMQREKSENADKTA
Sbjct: 301 RTIALFYLGSFDSIVRRCMMQREKSENADKTA 332
>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
sapiens]
Length = 339
Score = 92.4 bits (228), Expect = 5e-19
Identities = 73/264 (27%), Positives = 127/264 (48%), Gaps = 36/264 (13%)
Query: 35 VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKE-IEMHSINDKQVVLCISVD 93
V VTG SSGIG+ +A + K G + L AR +L + K+ +E ++ +K + L + +D
Sbjct: 53 VWVTGASSGIGEELAYQLSKLGVSLVLSARRVHELERVKRRCLENGNLKEKDI-LVLPLD 111
Query: 94 VSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPS 153
++ D E K ++ G +D+LVN GM+ D + + +L+ +NYLG+V +
Sbjct: 112 LT-DTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIELNYLGTVSLT 170
Query: 154 RAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITV 213
+ V+ M ER+ G+IV V+S G + + Y ASK A+RG L+ E+ Y
Sbjct: 171 KCVLPHMIERKQGKIVTVNSILGIISVPLSIGYCASKHALRGFFNGLRTELATY------ 224
Query: 214 AYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNFNSSLGSDG-- 271
PG N +C P V IV++++ G ++G++G
Sbjct: 225 --------PGIIVSN---------------IC-PGPVQSNIVENSLAGEVTKTIGNNGDQ 260
Query: 272 -YMLSALTCGMAPVTSITEGLQQV 294
+ ++ C + S+ L++V
Sbjct: 261 SHKMTTSRCVRLMLISMANDLKEV 284
>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
sapiens]
Length = 325
Score = 91.3 bits (225), Expect = 1e-18
Identities = 61/189 (32%), Positives = 99/189 (52%), Gaps = 3/189 (1%)
Query: 30 LPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQV--V 87
L A VV+TG +SG+GK A Y GA + L RN L + +E+ Q
Sbjct: 50 LRNAVVVITGATSGLGKECAKVFYAAGAKLVLCGRNGGALEELIRELTASHATKVQTHKP 109
Query: 88 LCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYL 147
++ D++ D + + + G VD+LVN AG++ G D V +R+M NY
Sbjct: 110 YLVTFDLT-DSGAIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYF 168
Query: 148 GSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPY 207
G V ++A++ +M +RR G IV +SS G++ + +AY+ASK A + + L+ E++ Y
Sbjct: 169 GPVALTKALLPSMIKRRQGHIVAISSIQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228
Query: 208 NVYITVAYP 216
+ +TV P
Sbjct: 229 EIEVTVISP 237
>gi|157739938 dehydrogenase/reductase (SDR family) member 7C [Homo
sapiens]
Length = 311
Score = 85.5 bits (210), Expect = 6e-17
Identities = 68/223 (30%), Positives = 113/223 (50%), Gaps = 14/223 (6%)
Query: 1 MLLLAAAFL-VAFVLLLYM-VSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAF 58
ML+L L ++ +L +Y VS L S A+ VV+T SG+GK A + GA
Sbjct: 6 MLMLPLLLLGISGLLFIYQEVSRLWSKS--AVQNKVVVITDAISGLGKECARVFHTGGAR 63
Query: 59 ITLVARNEDKLLQAKKEI-----EMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLG 113
+ L +N ++L + + K V+L +S D + V +V K+ + G
Sbjct: 64 LVLCGKNWERLENLYDALISVADPSKTFTPKLVLLDLS-----DISCVPDVAKEVLDCYG 118
Query: 114 PVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSS 173
VD+L+N A + V G + + +++M NY G + ++A++ M RR G+IV V++
Sbjct: 119 CVDILINNASVKVKGPAHKISLELDKKIMDANYFGPITLTKALLPNMISRRTGQIVLVNN 178
Query: 174 QAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYP 216
G+ G+ T Y+ASK A G + L+ EV+ Y+V I+ P
Sbjct: 179 IQGKFGIPFRTTYAASKHAALGFFDCLRAEVEEYDVVISTVSP 221
>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
Length = 311
Score = 84.3 bits (207), Expect = 1e-16
Identities = 57/188 (30%), Positives = 99/188 (52%), Gaps = 16/188 (8%)
Query: 35 VVVTGGSSGIGKCIAIECY---KQGAFITLVARN---EDKLLQAKKEIEMHSINDKQVVL 88
V+++G SSGIG +A++ K+ + R+ ++ L A E ++ Q+ +
Sbjct: 8 VLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQTLTVAQLDV 67
Query: 89 CISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLG 148
C V+Q + ++ G VD+LVN AGM + G E L ++ + + N+ G
Sbjct: 68 CSDESVAQCLSCIQ----------GEVDVLVNNAGMGLVGPLEGLSLAAMQNVFDTNFFG 117
Query: 149 SVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYN 208
+V +AV+ MK RR G IV +SS G G+ Y+ASKFA+ G E+L +++ +N
Sbjct: 118 AVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVIFNDVYAASKFALEGFFESLAIQLLQFN 177
Query: 209 VYITVAYP 216
++I++ P
Sbjct: 178 IFISLVEP 185
>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
Length = 736
Score = 81.6 bits (200), Expect = 9e-16
Identities = 63/236 (26%), Positives = 107/236 (45%), Gaps = 23/236 (9%)
Query: 27 PLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNED-------KLLQAKKEIEMH 79
PL G V+VTG +G+G+ A+ ++GA + + D L K E+
Sbjct: 4 PLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEEIR 63
Query: 80 SINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFE 139
K V SV+ + E V+K A + G +D++VN AG+ F + ++
Sbjct: 64 RRGGKAVANYDSVE------EGEKVVKTALDAFGRIDVVVNNAGILRDRSFARISDEDWD 117
Query: 140 RLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEA 199
+ ++ GS +RA MK+++ GRI+ SS +G G FG YSA+K + GLA +
Sbjct: 118 IIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYGNFGQANYSAAKLGLLGLANS 177
Query: 200 LQMEVKPYNVYITVAYPPDTDTPGFAEENRTKPLETRLISETTSVCKPEQVAKQIV 255
L +E + N++ P ++ +T + + KPE VA ++
Sbjct: 178 LAIEGRKSNIHCNTIAP----------NAGSRMTQTVMPEDLVEALKPEYVAPLVL 223
>gi|40254992 carbonic reductase 4 [Homo sapiens]
Length = 237
Score = 81.3 bits (199), Expect = 1e-15
Identities = 60/198 (30%), Positives = 97/198 (48%), Gaps = 14/198 (7%)
Query: 37 VTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQ 96
V GGS GIG+ +A ++G + ++ARN + A ++ L S DV++
Sbjct: 7 VFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLGGDH-------LAFSCDVAK 59
Query: 97 DYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAV 156
+++ V+N ++ ++ LG V+ LVN AG+ G + + N LGS+ +A
Sbjct: 60 EHD-VQNTFEELEKHLGRVNFLVNAAGINRDGLLVRTKTEDMVSQLHTNLLGSMLTCKAA 118
Query: 157 ITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVAYP 216
+ TM +++ G IV V S G G G + YSASK + G + AL EV + + V
Sbjct: 119 MRTMIQQQGGSIVNVGSIVGLKGNSGQSVYSASKGGLVGFSRALAKEVARKKIRVNVV-- 176
Query: 217 PDTDTPGFAEENRTKPLE 234
PGF + TK L+
Sbjct: 177 ----APGFVHTDMTKDLK 190
>gi|40807363 epidermal retinal dehydrogenase 2 [Homo sapiens]
Length = 309
Score = 78.6 bits (192), Expect = 7e-15
Identities = 61/209 (29%), Positives = 99/209 (47%), Gaps = 9/209 (4%)
Query: 12 FVLLLYMVSPLISPKPLA-LPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLL 70
F LL M+ L+ PKP + G V++TG SG+G+ +A++ + G+ + L N++
Sbjct: 20 FSLLEAMIFALL-PKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNE 78
Query: 71 QAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKF 130
+ K C D SQ V V Q ++++G V +L+N AG+ KF
Sbjct: 79 ETCKMAREAGATRVHAYTC---DCSQKEG-VYRVADQVKKEVGDVSILINNAGIVTGKKF 134
Query: 131 EDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASK 190
D E+ +N+ ++ +A + M G +V +SS AG G+ G Y ASK
Sbjct: 135 LDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASK 194
Query: 191 FAIRGLAEALQMEV---KPYNVYITVAYP 216
FA G AE++ +E K + T+ P
Sbjct: 195 FAAFGFAESVFVETFVQKQKGIKTTIVCP 223
>gi|32455239 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 75.9 bits (185), Expect = 5e-14
Identities = 59/191 (30%), Positives = 94/191 (49%), Gaps = 9/191 (4%)
Query: 26 KPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQ 85
+P L G V+VTG S GIG+ +A K GA + + AR+++ L +++ H +
Sbjct: 28 RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETL----QKVVSHCLELGA 83
Query: 86 VVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLV-NCAGMAVSGKFEDLEVSTFERLMSI 144
+D E + QA + +G +DML+ N F D ++ + M +
Sbjct: 84 ASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHD-DIHHVRKSMEV 142
Query: 145 NYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQME- 203
N+L V + A + +K+ G IV VSS AG++ AYSASKFA+ G +++ E
Sbjct: 143 NFLSYVVLTVAALPMLKQSN-GSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEY 201
Query: 204 -VKPYNVYITV 213
V NV IT+
Sbjct: 202 SVSRVNVSITL 212
>gi|5031765 11-beta-hydroxysteroid dehydrogenase 1 [Homo sapiens]
Length = 292
Score = 75.9 bits (185), Expect = 5e-14
Identities = 59/191 (30%), Positives = 94/191 (49%), Gaps = 9/191 (4%)
Query: 26 KPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQ 85
+P L G V+VTG S GIG+ +A K GA + + AR+++ L +++ H +
Sbjct: 28 RPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETL----QKVVSHCLELGA 83
Query: 86 VVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLV-NCAGMAVSGKFEDLEVSTFERLMSI 144
+D E + QA + +G +DML+ N F D ++ + M +
Sbjct: 84 ASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHD-DIHHVRKSMEV 142
Query: 145 NYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQME- 203
N+L V + A + +K+ G IV VSS AG++ AYSASKFA+ G +++ E
Sbjct: 143 NFLSYVVLTVAALPMLKQSN-GSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEY 201
Query: 204 -VKPYNVYITV 213
V NV IT+
Sbjct: 202 SVSRVNVSITL 212
>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
Length = 341
Score = 72.8 bits (177), Expect = 4e-13
Identities = 70/273 (25%), Positives = 117/273 (42%), Gaps = 30/273 (10%)
Query: 8 FLVAFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITL------ 61
F V + +L L+ PK ++ G ++TG SG+G+ A+E ++ A + L
Sbjct: 12 FKVLWAFVLAAARWLVRPKEKSVAGQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQ 71
Query: 62 -------VARNEDKLLQAKKEIEMHSINDKQVVL--------CISVDVSQDYNQVENVIK 106
+ R+ + L+A + + N ++ +L + DV + N V +
Sbjct: 72 SNEETAGMVRHIYRDLEAADAAALQAGNGEEEILPHCNLQVFTYTCDVGKREN-VYLTAE 130
Query: 107 QAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVG 166
+ ++++G V +LVN AG+ + ER M +N + ++A + TM E G
Sbjct: 131 RVRKEVGEVSVLVNNAGVVSGHHLLECPDELIERTMMVNCHAHFWTTKAFLPTMLEINHG 190
Query: 167 RIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPY---NVYITVAYPPDTDTPG 223
IV V+S G G Y ASKF + G E+L E+K + T+ P DT
Sbjct: 191 HIVTVASSLGLFSTAGVEDYCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGM 250
Query: 224 FAEENRTKPLETRLISETTSVCKPEQVAKQIVK 256
F K +E L KP+ KQ +K
Sbjct: 251 FRGCRIRKEIEPFL-----PPLKPDYCVKQAMK 278
>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
Length = 318
Score = 70.1 bits (170), Expect = 3e-12
Identities = 64/203 (31%), Positives = 95/203 (46%), Gaps = 13/203 (6%)
Query: 3 LLAAAFLVAFVLLLYMVSPLISP--------KPLALPGAHVVVTGGSSGIGKCIAIECYK 54
L+ L+ LLYM +P I + LPG VVVTG ++GIGK A E +
Sbjct: 4 LMFPLLLLLLPFLLYMAAPQIRKMLSSGVCTSTVQLPGKVVVVTGANTGIGKETAKELAQ 63
Query: 55 QGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGP 114
+GA + L R+ +K KEI+ + N Q VL +D+S D + K +
Sbjct: 64 RGARVYLACRDVEKGELVAKEIQTTTGN--QQVLVRKLDLS-DTKSIRAFAKGFLAEEKH 120
Query: 115 VDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQ 174
+ +L+N AG+ + + + FE + +N+LG + ++ +KE RIV VSS
Sbjct: 121 LHVLINNAGVMMCPYSKTAD--GFEMHIGVNHLGHFLLTHLLLEKLKESAPSRIVNVSSL 178
Query: 175 AGQLGLFGFTAYSASKFAIRGLA 197
A LG F KF GLA
Sbjct: 179 AHHLGRIHFHNLQGEKFYNAGLA 201
>gi|4758504 hydroxysteroid (17-beta) dehydrogenase 10 isoform 1
[Homo sapiens]
Length = 261
Score = 69.7 bits (169), Expect = 3e-12
Identities = 61/207 (29%), Positives = 95/207 (45%), Gaps = 22/207 (10%)
Query: 29 ALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLV-ARNEDKLLQAKKEIEMHSINDKQVV 87
++ G V+TGG+SG+G A QGA L+ N QAKK + + V
Sbjct: 7 SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKK------LGNNCVF 60
Query: 88 LCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLE------VSTFERL 141
V +D V+ + A+ K G VD+ VNCAG+AV+ K +L+ + F+R+
Sbjct: 61 APADVTSEKD---VQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRV 117
Query: 142 MSINYLGSVYPSRAVITTMKER------RVGRIVFVSSQAGQLGLFGFTAYSASKFAIRG 195
+ +N +G+ R V M + + G I+ +S A G G AYSASK I G
Sbjct: 118 LDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
Query: 196 LAEALQMEVKPYNVYITVAYPPDTDTP 222
+ + ++ P + + P TP
Sbjct: 178 MTLPIARDLAPIGIRVMTIAPGLFGTP 204
>gi|223646115 short chain dehydrogenase/reductase family 16C, member
6 [Homo sapiens]
Length = 323
Score = 68.9 bits (167), Expect = 6e-12
Identities = 73/293 (24%), Positives = 124/293 (42%), Gaps = 33/293 (11%)
Query: 12 FVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQ 71
+ L +V +I K + G V+ TG SG+G+ +AI + GA + L N++ ++
Sbjct: 16 YYFLESLVYKIIPKKKKNVAGEIVLTTGAGSGLGRQLAIYFARFGAILVLWDVNQEGNME 75
Query: 72 AKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFE 131
+ + V + D S + +V V Q +++ G V +LVN A + F
Sbjct: 76 T---CRLAKEKGGKKVFPYTCDCS-NRQEVYRVADQVRKEFGDVTILVNNADLVTGKPFL 131
Query: 132 DLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFT------- 184
D+ E+ +N + + +A + + + G +V +SS AG +G+ G +
Sbjct: 132 DIPDHMVEKSFLVNAITHFWTCKAFLPAVIKANHGHLVCISSIAGVVGINGLSDEYFVSP 191
Query: 185 AYSASKFAIRGLAEALQME---VKPYNVYITVAYPPDTDT--------------PGFAEE 227
YSASKFA G AE+L E +K V T+ P +T P +E
Sbjct: 192 YYSASKFAAFGFAESLFFELTMIKKTEVKSTIVCPHFINTGMFEGCTSKYPFLLPILEQE 251
Query: 228 NRTKPLETRLISETTSVCKPE-----QVAKQIVKDAIQGNFNSSLGSDGYMLS 275
K + ++ E + P+ + KQI+ + F LG D M S
Sbjct: 252 YVAKKILNAILEEQVYLMIPKFAYIGLILKQIISPKMLIAFGEYLGVDTCMAS 304
>gi|7705855 hydroxysteroid (17-beta) dehydrogenase 12 [Homo sapiens]
Length = 312
Score = 68.9 bits (167), Expect = 6e-12
Identities = 57/189 (30%), Positives = 93/189 (49%), Gaps = 10/189 (5%)
Query: 32 GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCIS 91
G VVTG + GIGK A E K G + L++R++DKL Q EI+ K I+
Sbjct: 50 GEWAVVTGSTDGIGKSYAEELAKHGMKVVLISRSKDKLDQVSSEIKE---KFKVETRTIA 106
Query: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEV----STFERLMSINYL 147
VD + + + + IK L + +LVN GM+ L+V + +++++IN L
Sbjct: 107 VDFASE--DIYDKIKTGLAGL-EIGILVNNVGMSYEYPEYFLDVPDLDNVIKKMININIL 163
Query: 148 GSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPY 207
++ V+ M ER G I+ +SS +G L + T YSA+K + ++ L E +
Sbjct: 164 SVCKMTQLVLPGMVERSKGAILNISSGSGMLPVPLLTIYSATKTFVDFFSQCLHEEYRSK 223
Query: 208 NVYITVAYP 216
V++ P
Sbjct: 224 GVFVQSVLP 232
>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
sapiens]
Length = 270
Score = 68.2 bits (165), Expect = 1e-11
Identities = 60/239 (25%), Positives = 109/239 (45%), Gaps = 17/239 (7%)
Query: 32 GAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCIS 91
G VVVTGG GIG I GA + + ++E ++E+ +LC
Sbjct: 9 GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKDESGGRALEQELP-----GAVFILC-- 61
Query: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGM-AVSGKFEDLEVSTFERLMSINYLGSV 150
DV+Q+ + V+ ++ + + G +D +VN AG + E+ F +L+ +N LG+
Sbjct: 62 -DVTQE-DDVKTLVSETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQLLELNLLGTY 119
Query: 151 YPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVY 210
++ + +++ + G ++ +SS G +G Y A+K A+ + +AL ++ PY V
Sbjct: 120 TLTKLALPYLRKSQ-GNVINISSLVGAIGQAQAVPYVATKGAVTAMTKALALDESPYGVR 178
Query: 211 ITVAYPPDTDTPGFAE------ENRTKPLETRLISETTSVCKPEQVAKQIVKDAIQGNF 263
+ P + TP + E + R E L + +P +V V A + NF
Sbjct: 179 VNCISPGNIWTPLWEELAALMPDPRATIREGMLAQPLGRMGQPAEVGAAAVFLASEANF 237
>gi|83715985 hydroxysteroid (17-beta) dehydrogenase 10 isoform 2
[Homo sapiens]
Length = 252
Score = 67.8 bits (164), Expect = 1e-11
Identities = 59/197 (29%), Positives = 93/197 (47%), Gaps = 22/197 (11%)
Query: 29 ALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLV-ARNEDKLLQAKKEIEMHSINDKQVV 87
++ G V+TGG+SG+G A QGA L+ N QAKK + + V
Sbjct: 7 SVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKK------LGNNCVF 60
Query: 88 LCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLE------VSTFERL 141
V +D V+ + A+ K G VD+ VNCAG+AV+ K +L+ + F+R+
Sbjct: 61 APADVTSEKD---VQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRV 117
Query: 142 MSINYLGSVYPSRAVITTMKER------RVGRIVFVSSQAGQLGLFGFTAYSASKFAIRG 195
+ +N +G+ R V M + + G I+ +S A G G AYSASK I G
Sbjct: 118 LDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVG 177
Query: 196 LAEALQMEVKPYNVYIT 212
+ + ++ P ++ T
Sbjct: 178 MTLPIARDLAPIGLFGT 194
>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
sapiens]
Length = 278
Score = 67.0 bits (162), Expect = 2e-11
Identities = 50/182 (27%), Positives = 88/182 (48%), Gaps = 6/182 (3%)
Query: 36 VVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVS 95
+VT + GIG IA + GA + + +R + + QA ++ ++ V V +
Sbjct: 36 LVTASTDGIGFAIARRLAQDGAHVVVSSRKQQNVDQAVATLQGEGLSVTGTVC--HVGKA 93
Query: 96 QDYNQVENVIKQAQEKLGPVDMLV-NCAGMAVSGKFEDLEVSTFERLMSINYLGSVYPSR 154
+D E ++ A + G +D+LV N A G D+ +++ + IN ++
Sbjct: 94 EDR---ERLVATAVKLHGGIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTK 150
Query: 155 AVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVA 214
AV+ M++R G +V VSS A GF+ Y+ SK A+ GL + L +E+ P N+ +
Sbjct: 151 AVVPEMEKRGGGSVVIVSSIAAFSPSPGFSPYNVSKTALLGLTKTLAIELAPRNIRVNCL 210
Query: 215 YP 216
P
Sbjct: 211 AP 212
>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
Length = 244
Score = 67.0 bits (162), Expect = 2e-11
Identities = 54/191 (28%), Positives = 87/191 (45%), Gaps = 16/191 (8%)
Query: 28 LALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVV 87
L L G V+VTG GIG+ + GA + V+R + L D V
Sbjct: 3 LFLAGRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADL-------------DSLVR 49
Query: 88 LCISVD-VSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINY 146
C ++ V D E ++A +GPVD+LVN A +A+ F ++ F+R +N
Sbjct: 50 ECPGIEPVCVDLGDWE-ATERALGSVGPVDLLVNNAAVALLQPFLEVTKEAFDRSFEVNL 108
Query: 147 LGSVYPSRAVITTMKERRV-GRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVK 205
+ S+ V + R V G IV VSSQ Q + + Y ++K A+ L + + +E+
Sbjct: 109 RAVIQVSQIVARGLIARGVPGAIVNVSSQCSQRAVTNHSVYCSTKGALDMLTKVMALELG 168
Query: 206 PYNVYITVAYP 216
P+ + + P
Sbjct: 169 PHKIRVNAVNP 179
>gi|44680136 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 66.6 bits (161), Expect = 3e-11
Identities = 46/185 (24%), Positives = 94/185 (50%), Gaps = 7/185 (3%)
Query: 35 VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHS---INDKQVVLCIS 91
V+VTG SG G +A + +G + +DK KE++ + + Q+ +C S
Sbjct: 58 VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
Query: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVY 151
+V + V + +K ++ + LVN AG++ G+ E + T++++ +N G+V
Sbjct: 118 EEVEKVVEIVRSSLKDPEKGMWG---LVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVR 174
Query: 152 PSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYI 211
+++ + ++ R GR+V +SS G++ + Y +KF + ++ L+ E+ P V +
Sbjct: 175 MTKSFLPLIR-RAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
Query: 212 TVAYP 216
+V P
Sbjct: 234 SVVEP 238
>gi|44680133 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 66.6 bits (161), Expect = 3e-11
Identities = 46/185 (24%), Positives = 94/185 (50%), Gaps = 7/185 (3%)
Query: 35 VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHS---INDKQVVLCIS 91
V+VTG SG G +A + +G + +DK KE++ + + Q+ +C S
Sbjct: 58 VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
Query: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVY 151
+V + V + +K ++ + LVN AG++ G+ E + T++++ +N G+V
Sbjct: 118 EEVEKVVEIVRSSLKDPEKGMWG---LVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVR 174
Query: 152 PSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYI 211
+++ + ++ R GR+V +SS G++ + Y +KF + ++ L+ E+ P V +
Sbjct: 175 MTKSFLPLIR-RAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
Query: 212 TVAYP 216
+V P
Sbjct: 234 SVVEP 238
>gi|17738292 3-hydroxybutyrate dehydrogenase, type 1 precursor [Homo
sapiens]
Length = 343
Score = 66.6 bits (161), Expect = 3e-11
Identities = 46/185 (24%), Positives = 94/185 (50%), Gaps = 7/185 (3%)
Query: 35 VVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHS---INDKQVVLCIS 91
V+VTG SG G +A + +G + +DK KE++ + + Q+ +C S
Sbjct: 58 VLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSS 117
Query: 92 VDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLGSVY 151
+V + V + +K ++ + LVN AG++ G+ E + T++++ +N G+V
Sbjct: 118 EEVEKVVEIVRSSLKDPEKGMWG---LVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVR 174
Query: 152 PSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYI 211
+++ + ++ R GR+V +SS G++ + Y +KF + ++ L+ E+ P V +
Sbjct: 175 MTKSFLPLIR-RAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKV 233
Query: 212 TVAYP 216
+V P
Sbjct: 234 SVVEP 238
>gi|40254986 hydroxysteroid dehydrogenase like 2 [Homo sapiens]
Length = 418
Score = 66.6 bits (161), Expect = 3e-11
Identities = 55/193 (28%), Positives = 92/193 (47%), Gaps = 18/193 (9%)
Query: 25 PKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNED---KLL----QAKKEIE 77
P L G V +TG S GIGK IA++ K GA I + A+ KLL A +EIE
Sbjct: 3 PNTGRLAGCTVFITGASRGIGKAIALKAAKDGANIVIAAKTAQPHPKLLGTIYTAAEEIE 62
Query: 78 MHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVST 137
++ K + + V +D Q+ +++A +K G +D+LVN A D
Sbjct: 63 --AVGGKALPCIVDV---RDEQQISAAVEKAIKKFGGIDILVNNASAISLTNTLDTPTKR 117
Query: 138 FERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSS--QAGQLGLFGFTAYSASKFA--- 192
+ +M++N G+ S+A I +K+ +V I+ +S + AY+ +K+
Sbjct: 118 LDLMMNVNTRGTYLASKACIPYLKKSKVAHILNISPPLNLNPVWFKQHCAYTIAKYGMSM 177
Query: 193 -IRGLAEALQMEV 204
+ G+AE + E+
Sbjct: 178 YVLGMAEEFKGEI 190
>gi|223718074 hydroxysteroid (17-beta) dehydrogenase 1 [Homo
sapiens]
Length = 328
Score = 65.5 bits (158), Expect = 6e-11
Identities = 52/185 (28%), Positives = 93/185 (50%), Gaps = 13/185 (7%)
Query: 35 VVVTGGSSGIGKCIAIECYKQGA-----FITLV-ARNEDKLLQAKKEIEMHSINDKQVVL 88
V++TG SSGIG +A+ + + TL + + +L +A + + + + + L
Sbjct: 6 VLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQL 65
Query: 89 CISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSINYLG 148
+ +D V ++ E G VD+LV AG+ + G E L ++ +N +G
Sbjct: 66 DV-----RDSKSVAAARERVTE--GRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVG 118
Query: 149 SVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYN 208
+V +A + MK R GR++ S G +GL Y ASKFA+ GL E+L + + P+
Sbjct: 119 TVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFG 178
Query: 209 VYITV 213
V++++
Sbjct: 179 VHLSL 183
>gi|38348362 short-chain dehydrogenase/reductase 10 isoform e [Homo
sapiens]
Length = 315
Score = 65.5 bits (158), Expect = 6e-11
Identities = 62/213 (29%), Positives = 106/213 (49%), Gaps = 9/213 (4%)
Query: 27 PLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQV 86
P +L GA V++TG ++G+G+ +A + G+ + L A E L +K +
Sbjct: 24 PASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALL---QKVVGNCRKLGAPK 80
Query: 87 VLCISVDVSQDYNQVENVIKQAQEKLGPVDMLV-NCAGMAVSGKFEDLEVSTFERLMSIN 145
V I+ D++ E+V++ A +KLG +D LV N G A +G +T LM +N
Sbjct: 81 VFYIAADMASP-EAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQAT-RWLMQVN 138
Query: 146 YLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEAL--QME 203
++ V + + ++ + + G +V VSS G++ T YSA+KFA+ G +L +++
Sbjct: 139 FVSYVQLTSRALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELD 197
Query: 204 VKPYNVYITVAYPPDTDTPGFAEENRTKPLETR 236
V+ NV IT+ D AE R+ R
Sbjct: 198 VQDVNVAITMCVLGLRDRASAAEAVRSSTSRPR 230
>gi|19923817 peroxisomal trans-2-enoyl-CoA reductase [Homo sapiens]
Length = 303
Score = 65.1 bits (157), Expect = 8e-11
Identities = 47/183 (25%), Positives = 85/183 (46%), Gaps = 14/183 (7%)
Query: 27 PLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQV 86
P L G +VTGG++GIGK I E + G+ + + +R ++L A E++ + KQ
Sbjct: 13 PGLLQGQVAIVTGGATGIGKAIVKELLELGSNVVIASRKLERLKSAADELQANLPPTKQA 72
Query: 87 -VLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKFEDLEVSTFERLMSIN 145
V+ I ++ + +V N++K + G ++ LVN G E + + ++ N
Sbjct: 73 RVIPIQCNIRNE-EEVNNLVKSTLDTFGKINFLVNNGGGQFLSPAEHISSKGWHAVLETN 131
Query: 146 YLGSVYPSRAVITTMKERRVGRIV------------FVSSQAGQLGLFGFTAYSASKFAI 193
G+ Y +AV ++ + G IV V S A + G++ T A ++A
Sbjct: 132 LTGTFYMCKAVYSSWMKEHGGSIVNIIVPTKAGFPLAVHSGAARAGVYNLTKSLALEWAC 191
Query: 194 RGL 196
G+
Sbjct: 192 SGI 194
>gi|38424085 short-chain dehydrogenase/reductase 10 isoform b [Homo
sapiens]
Length = 286
Score = 64.7 bits (156), Expect = 1e-10
Identities = 61/206 (29%), Positives = 104/206 (50%), Gaps = 9/206 (4%)
Query: 27 PLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQV 86
P +L GA V++TG ++G+G+ +A + G+ + L A E L +K +
Sbjct: 24 PASLQGARVLLTGANAGVGEELAYHYARLGSHLVLTAHTEALL---QKVVGNCRKLGAPK 80
Query: 87 VLCISVDVSQDYNQVENVIKQAQEKLGPVDMLV-NCAGMAVSGKFEDLEVSTFERLMSIN 145
V I+ D++ E+V++ A +KLG +D LV N G A +G +T LM +N
Sbjct: 81 VFYIAADMASP-EAPESVVQFALDKLGGLDYLVLNHIGGAPAGTRARSPQAT-RWLMQVN 138
Query: 146 YLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEAL--QME 203
++ V + + ++ + + G +V VSS G++ T YSA+KFA+ G +L +++
Sbjct: 139 FVSYVQLTSRALPSLTDSK-GSLVVVSSLLGRVPTSFSTPYSAAKFALDGFFGSLRRELD 197
Query: 204 VKPYNVYITVAYPPDTDTPGFAEENR 229
V+ NV IT+ D AE R
Sbjct: 198 VQDVNVAITMCVLGLRDRASAAEAVR 223
>gi|5031737 dehydrogenase/reductase member 2 isoform 2 [Homo
sapiens]
Length = 280
Score = 64.3 bits (155), Expect = 1e-10
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)
Query: 36 VVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVS 95
VVTG +SGIG IA + GA + + +R + + +A +++ ++ +V V +
Sbjct: 40 VVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIV--CHVGKA 97
Query: 96 QDYNQVENVIKQAQEKLGPVDMLVNCAGM-AVSGKFEDLEVSTFERLMSINYLGSVYPSR 154
+D E ++ +A E G VD LV AG+ + G +++++S+N
Sbjct: 98 EDR---EQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 155 AVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVA 214
++ M+ RR G ++ VSS A + Y+ SK A+ GL L +E+ P ++ +
Sbjct: 155 QLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCV 213
Query: 215 YP 216
P
Sbjct: 214 VP 215
>gi|33667109 dehydrogenase/reductase member 2 isoform 1 [Homo
sapiens]
Length = 300
Score = 64.3 bits (155), Expect = 1e-10
Identities = 48/182 (26%), Positives = 88/182 (48%), Gaps = 7/182 (3%)
Query: 36 VVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLLQAKKEIEMHSINDKQVVLCISVDVS 95
VVTG +SGIG IA + GA + + +R + + +A +++ ++ +V V +
Sbjct: 40 VVTGSTSGIGFAIARRLARDGAHVVISSRKQQNVDRAMAKLQGEGLSVAGIV--CHVGKA 97
Query: 96 QDYNQVENVIKQAQEKLGPVDMLVNCAGM-AVSGKFEDLEVSTFERLMSINYLGSVYPSR 154
+D E ++ +A E G VD LV AG+ + G +++++S+N
Sbjct: 98 EDR---EQLVAKALEHCGGVDFLVCSAGVNPLVGSTLGTSEQIWDKILSVNVKSPALLLS 154
Query: 155 AVITTMKERRVGRIVFVSSQAGQLGLFGFTAYSASKFAIRGLAEALQMEVKPYNVYITVA 214
++ M+ RR G ++ VSS A + Y+ SK A+ GL L +E+ P ++ +
Sbjct: 155 QLLPYMENRR-GAVILVSSIAAYNPVVALGVYNVSKTALLGLTRTLALELAPKDIRVNCV 213
Query: 215 YP 216
P
Sbjct: 214 VP 215
>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
Length = 331
Score = 63.5 bits (153), Expect = 2e-10
Identities = 57/219 (26%), Positives = 95/219 (43%), Gaps = 18/219 (8%)
Query: 11 AFVLLLYMVSPLISPKPLALPGAHVVVTGGSSGIGKCIAIECYKQGAFITLVARNEDKLL 70
A VLL V+ P +PG V+VTG ++GIGK A+E ++G I L R+ +K
Sbjct: 17 AAVLLKDYVTGGACPSKATIPGKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCE 76
Query: 71 QAKKEIEMHSINDKQVVLCISVDVSQDYNQVENVIKQAQEKLGPVDMLVNCAGMAVSGKF 130
A K+I ++N + + + + I + +E+ VD+L+N AG+ +
Sbjct: 77 AAAKDIRGETLNHHVNARHLDLASLKSIREFAAKIIEEEER---VDILINNAGVMRCPHW 133
Query: 131 EDLEVSTFERLMSINYLGSVYPSRAVITTMKERRVGRIVFVSSQAGQLGLFGF------- 183
+ FE +N+LG + ++ +K RI+ +SS A G F
Sbjct: 134 TTED--GFEMQFGVNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQT 191
Query: 184 ------TAYSASKFAIRGLAEALQMEVKPYNVYITVAYP 216
AY SK AI + L ++ V + +P
Sbjct: 192 RKYNTKAAYCQSKLAIVLFTKELSRRLQGSGVTVNALHP 230
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.375
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 10,919,762
Number of Sequences: 37866
Number of extensions: 435783
Number of successful extensions: 1242
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 1130
Number of HSP's gapped (non-prelim): 79
length of query: 332
length of database: 18,247,518
effective HSP length: 103
effective length of query: 229
effective length of database: 14,347,320
effective search space: 3285536280
effective search space used: 3285536280
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.