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Search of human proteins with 4503593
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503593 epidermal growth factor receptor pathway substrate
15 isoform A [Homo sapiens]
(896 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503593 epidermal growth factor receptor pathway substrate 15... 1778 0.0
gi|229577185 epidermal growth factor receptor pathway substrate ... 1094 0.0
gi|10864047 epidermal growth factor receptor pathway substrate 1... 709 0.0
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 125 2e-28
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 125 2e-28
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 125 2e-28
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 120 4e-27
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 120 4e-27
gi|21361462 EH-domain containing 2 [Homo sapiens] 104 3e-22
gi|30240932 EH-domain containing 1 [Homo sapiens] 101 3e-21
gi|21264315 EH-domain containing 4 [Homo sapiens] 100 1e-20
gi|7657056 EH-domain containing 3 [Homo sapiens] 99 2e-20
gi|71061468 centromere protein E [Homo sapiens] 73 1e-12
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 71 5e-12
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 71 5e-12
gi|190886435 RALBP1 associated Eps domain containing 1 isoform a... 71 5e-12
gi|190886437 RALBP1 associated Eps domain containing 1 isoform b... 71 5e-12
gi|24308179 CTTNBP2 N-terminal like [Homo sapiens] 69 3e-11
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 67 6e-11
gi|125625322 RALBP1 associated Eps domain containing 2 isoform 2... 67 1e-10
gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens] 67 1e-10
gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens] 66 1e-10
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 66 1e-10
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 65 2e-10
gi|125625326 RALBP1 associated Eps domain containing 2 isoform 1... 65 2e-10
gi|205277396 dynactin 1 isoform 4 [Homo sapiens] 65 3e-10
gi|205277392 dynactin 1 isoform 3 [Homo sapiens] 65 3e-10
gi|13259508 dynactin 1 isoform 2 [Homo sapiens] 65 3e-10
gi|13259510 dynactin 1 isoform 1 [Homo sapiens] 65 3e-10
gi|38044112 restin isoform b [Homo sapiens] 65 4e-10
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 1778 bits (4605), Expect = 0.0
Identities = 896/896 (100%), Positives = 896/896 (100%)
Query: 1 MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLA 60
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLA
Sbjct: 1 MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLA 60
Query: 61 DTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAEL 120
DTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAEL
Sbjct: 61 DTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAEL 120
Query: 121 PWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML 180
PWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML
Sbjct: 121 PWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGML 180
Query: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240
DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD
Sbjct: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240
Query: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPP 300
GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPP
Sbjct: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPP 300
Query: 301 HVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKE 360
HVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKE
Sbjct: 301 HVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKE 360
Query: 361 DTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCA 420
DTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCA
Sbjct: 361 DTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCA 420
Query: 421 EEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQ 480
EEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQ
Sbjct: 421 EEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQ 480
Query: 481 HLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLN 540
HLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLN
Sbjct: 481 HLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLN 540
Query: 541 EHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDP 600
EHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDP
Sbjct: 541 EHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDP 600
Query: 601 FNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFR 660
FNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFR
Sbjct: 601 FNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFR 660
Query: 661 QSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESF 720
QSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESF
Sbjct: 661 QSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESF 720
Query: 721 GGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTR 780
GGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTR
Sbjct: 721 GGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTR 780
Query: 781 PCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADP 840
PCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADP
Sbjct: 781 PCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADP 840
Query: 841 SNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA 896
SNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA
Sbjct: 841 SNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA 896
>gi|229577185 epidermal growth factor receptor pathway substrate 15
isoform B [Homo sapiens]
Length = 582
Score = 1094 bits (2829), Expect = 0.0
Identities = 550/550 (100%), Positives = 550/550 (100%)
Query: 347 REKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKA 406
REKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKA
Sbjct: 33 REKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKA 92
Query: 407 QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEE 466
QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEE
Sbjct: 93 QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEE 152
Query: 467 SVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDY 526
SVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDY
Sbjct: 153 SVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDY 212
Query: 527 CSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVC 586
CSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVC
Sbjct: 213 CSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVC 272
Query: 587 SELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDP 646
SELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDP
Sbjct: 273 SELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDP 332
Query: 647 FKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDS 706
FKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDS
Sbjct: 333 FKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDS 392
Query: 707 ATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSED 766
ATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSED
Sbjct: 393 ATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSED 452
Query: 767 EPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDP 826
EPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDP
Sbjct: 453 EPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDP 512
Query: 827 FTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAI 886
FTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAI
Sbjct: 513 FTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAI 572
Query: 887 ALSKSEISEA 896
ALSKSEISEA
Sbjct: 573 ALSKSEISEA 582
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 709 bits (1829), Expect = 0.0
Identities = 415/916 (45%), Positives = 564/916 (61%), Gaps = 142/916 (15%)
Query: 11 QLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNK 70
Q+ +GN +YE YY+QVD TGRV AS+AA FLKKSGL D+ILGKIWDLAD +GKG L+K
Sbjct: 11 QIPTGNSLYESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDK 70
Query: 71 QEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKA 130
Q F+VALRLVACAQ+G EV+LS+LNL++PPP+FHDTSSPL+++ SA E WAV+ E+KA
Sbjct: 71 QGFYVALRLVACAQSGHEVTLSNLNLSMPPPKFHDTSSPLMVTPPSA-EAHWAVRVEEKA 129
Query: 131 KYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMF 190
K+D IF+SL P+NG LSGDKVKPVL+NSKLP+D+LGRVW+LSDID DG LDRDEFAVAM
Sbjct: 130 KFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLDRDEFAVAMH 189
Query: 191 LVYCALEKEPVPMSLPPALVPPSKRK---------------------------------- 216
LVY ALEKEPVP +LPP+L+PPSKRK
Sbjct: 190 LVYRALEKEPVPSALPPSLIPPSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVSSLN 249
Query: 217 ------------------TWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLP 258
WVV A+K ++DEIFLKTD D+DG+VSG EV+EIF+ +GL
Sbjct: 250 STGSLSPKHSLKQTQPTVNWVVPVADKMRFDEIFLKTDLDLDGYVSGQEVKEIFMHSGLT 309
Query: 259 STLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQK 318
LLAHIW+L DT+ GKLSKDQFALA + I QK+ KGIDPP VL+P+M+PPS+R +
Sbjct: 310 QNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKVSKGIDPPQVLSPDMVPPSERGTPGP 369
Query: 319 NIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQ 378
+ GS +F+ +KELD ++ EI LQREK ++EQD++EKE+ I+Q+TSEVQ+LQ+++
Sbjct: 370 DSSGSLGSGEFTGVKELDDISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLD 429
Query: 379 RENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQES 438
RE ++LQ+L+AQKQ Q+ LDE+D+QKA+L + L +VR+KC +E Q+ISSLK ++ SQES
Sbjct: 430 RETSSLQELEAQKQDAQDRLDEMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQES 489
Query: 439 QISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLME 498
+ + E++L +A+ EL+RLQQE +LE+S+++G+ QLE + + L+ +Q EI+ + KL +
Sbjct: 490 DLKSQEDDLNRAKSELNRLQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQ 549
Query: 499 MKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQES 558
L + + + +++GA S ++ ANL+E V
Sbjct: 550 ---LHESRQEAHRSLEQYDQVLDGAH-----GASLTDLANLSEGV--------------- 586
Query: 559 PARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLD 618
S E G D+ A+ NN DPF + D
Sbjct: 587 ---SLAERGSFGAMDDPFKNKALL------FSNNTQELHPDPFQTE-------------D 624
Query: 619 FFQSDPFVGSDPFKDDPF----------GKIDPFGGDPFKGSDPF---ASDCFFRQST-- 663
F+SDPF G+DPFK DPF DPFGGDPFK SDPF A+D FF++ T
Sbjct: 625 PFKSDPFKGADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFRGSATDDFFKKQTKN 684
Query: 664 DPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASV--FGNESFG 721
DPF ++DPF+ N S + ++ + +DPF+ + S +DPF ++ FG+ SF
Sbjct: 685 DPF---TSDPFT-KNPSLPSKLDPFESSDPFSSS----SVSSKGSDPFGTLDPFGSGSFN 736
Query: 722 G--GFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPT 779
GFADFS +SK PF S+ + F + KS+ + PALPPK P
Sbjct: 737 SAEGFADFSQMSKPPPSGPFTSSLGGA---------GFSDDPFKSKQDTPALPPKKPAPP 787
Query: 780 RPCPLPPGKRS-INKLDSPDPFKLNDPFQPF---PGNDSPKEK---DPEIFCDPFTSATT 832
RP P P GK + +++L S D + DPFQP G+ +K DP DPF ++
Sbjct: 788 RPKP-PSGKSTPVSQLGSADFPEAPDPFQPLGADSGDPFQSKKGFGDPFSGKDPFVPSSA 846
Query: 833 TTNKEADPSNFANFSA 848
+A S FA+F++
Sbjct: 847 AKPSKASASGFADFTS 862
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 125 bits (314), Expect = 2e-28
Identities = 131/526 (24%), Positives = 224/526 (42%), Gaps = 52/526 (9%)
Query: 21 KYYRQVDT--GNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
K+ RQ D + G + A F +SGLP +L +IW L+D + G +++QEF +A++
Sbjct: 25 KHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMK 84
Query: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS 138
L+ G ++ + + PP F SPL+ + +P P+ I
Sbjct: 85 LIKLKLQGQQLPVVLPPIMKQPPMF----SPLISARFGMGSMPNLSIPQPLPPAAPITSL 140
Query: 139 LSPVNG-----FLSGDKVKPVLLNSKLP------VDILGRVWELSDIDHD-------GML 180
S +G + + P + S LP + L + S + H G
Sbjct: 141 SSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGF 200
Query: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240
A L+ + P + W V + KY + F DK M
Sbjct: 201 GGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMS 260
Query: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDP- 299
G++SG + R L++ L T LA IW+L D G+L ++F LA HL + K P
Sbjct: 261 GYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTD--MAKAGQPL 318
Query: 300 PHVLTPEMIPPSDRASLQ-KNIIGSSP----VADFSAIKELDTLNNEIVDLQREKNNVEQ 354
P L PE++PPS R Q +I G+ P + + K+L + E+ N+E
Sbjct: 319 PLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMEL 378
Query: 355 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
+ + + +Q+ + Q E + ++LQ Q+ + Q L++ E++ +LE Q +E
Sbjct: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE 438
Query: 415 VRKKCAEEAQLISSLKAELTSQE----SQISTYE--EELAKAREELSRLQQETAELEESV 468
R+K E + + K EL Q +I E + + +EE+ RL + L +
Sbjct: 439 ERRKDIERRE---AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
Query: 469 E---------SGKAQLEPLQQHLQDSQQEISSMQ--MKLMEMKDLE 503
E SG+ Q L++ Q ++ E+ Q +++ME+K L+
Sbjct: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ 541
Score = 103 bits (257), Expect = 7e-22
Identities = 112/461 (24%), Positives = 185/461 (40%), Gaps = 79/461 (17%)
Query: 106 TSSPLLISGTS--AAELPWAVKPEDKAKYDAIFDSLSP-VNGFLSGDKVKPVLLNSKLPV 162
TSS +SG S WAV + KY F++L ++G+LSG + + LL S L
Sbjct: 220 TSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ 279
Query: 163 DILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVP----------- 211
L +W L+D+D DG L +EF +AM L A +P+P++LPP LVP
Sbjct: 280 TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDS 339
Query: 212 ---------------PSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTG 256
P K+ KA Y+ ++ +K + + RE K
Sbjct: 340 INGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQ 398
Query: 257 LPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASL 316
W + + K Q L L Q+ ++ E +R
Sbjct: 399 KEK----EEWERKQRELQEQEWKKQLELEKRLEKQRELE-----RQREEERRKDIERREA 449
Query: 317 QKNIIGSSPVADFSAIKELDTLNN------EIVDLQREKNNVEQDLKEKEDTIKQRTSEV 370
K + ++ I+ + LN EIV L +K N+ +L+ +Q + +
Sbjct: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRL 509
Query: 371 QDLQDEVQRENTNLQ--------------KLQAQKQQVQELLDELDEQKAQLEEQLKEVR 416
QD++ + Q + T L+ +LQ + Q+ Q L L +K L E++K ++
Sbjct: 510 QDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
Query: 417 -------------KKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463
KK E+ +L LK Q+ E+E A E+ + E
Sbjct: 570 FSNTPDSGVSLLHKKSLEKEELCQRLK-------EQLDALEKETASKLSEMDSFNNQLKE 622
Query: 464 LEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLEN 504
L E+ + + LE L + +D +EI +++LM+ K LE+
Sbjct: 623 LRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLED 663
Score = 85.9 bits (211), Expect = 2e-16
Identities = 35/91 (38%), Positives = 59/91 (64%)
Query: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
WA+ E++ K+D FD+L P G+++GD+ + L S LP +L +W LSD++ DG +D
Sbjct: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
Query: 182 RDEFAVAMFLVYCALEKEPVPMSLPPALVPP 212
+ EF++AM L+ L+ + +P+ LPP + P
Sbjct: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
Score = 64.7 bits (156), Expect = 4e-10
Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 2/93 (2%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
W ++ E+ K+D F K G+++G + R FL++GLP+ +LA IW+L D GK+
Sbjct: 16 WAITSEERTKHDRQFDNL-KPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPP 310
+ +F++A LI KL +G P VL P M P
Sbjct: 75 DQQEFSIAMKLIKLKL-QGQQLPVVLPPIMKQP 106
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y + + +D +G + A L +S L L IW LAD DG G L +EF +A+
Sbjct: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Query: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAA-----------ELPWAVKPE 127
L A+ G + L +L + PP F I+GT + +LP + +
Sbjct: 308 LTDMAKAGQPLPL-TLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDK 366
Query: 128 DKAKYD 133
KA Y+
Sbjct: 367 RKANYE 372
Score = 45.1 bits (105), Expect = 3e-04
Identities = 41/195 (21%), Positives = 86/195 (44%), Gaps = 34/195 (17%)
Query: 346 QREKNNVEQDLKEKEDTIKQRTSEV-----QDLQDEVQRENTNLQKLQAQKQQVQELLDE 400
+ + ++E+ K++ +QR E Q+L ++ RE + +L ++K+ + L+
Sbjct: 438 EERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEA 497
Query: 401 LDEQKAQLEEQLKEVR--------------KKCAEEAQLISSLKAELTSQESQISTYEEE 446
L+ + Q+ +L++VR K+C E I L+ EL ++++ E
Sbjct: 498 LNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPE 557
Query: 447 LAKAREELSRLQ-------------QETAELEESVESGKAQLEPLQQHLQDSQQEISSMQ 493
E + +Q +++ E EE + K QL+ L++ E+ S
Sbjct: 558 KQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFN 617
Query: 494 MKLMEMKDLENHNSQ 508
+L E++ E +N+Q
Sbjct: 618 NQLKELR--ETYNTQ 630
Score = 38.5 bits (88), Expect = 0.028
Identities = 38/125 (30%), Positives = 64/125 (51%), Gaps = 20/125 (16%)
Query: 330 SAIKELDTLNNEIVDLQREKNN----VEQDLKEKEDTIKQ------RTSEVQDLQDEVQR 379
S + E+D+ NN++ +L+ N +EQ K K D +K+ + + L+DE R
Sbjct: 608 SKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAAR 667
Query: 380 E----NTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL--ISSLKAEL 433
+ NL K +K++ +E L E+K Q E+++E +K AEE Q +LKAE
Sbjct: 668 KAKQGKENLWKENLRKEE-EEKQKRLQEEKTQ--EKIQEEERK-AEEKQRKDKDTLKAEE 723
Query: 434 TSQES 438
+E+
Sbjct: 724 KKRET 728
Score = 38.1 bits (87), Expect = 0.037
Identities = 34/135 (25%), Positives = 61/135 (45%), Gaps = 9/135 (6%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
++LD L E E ++ LKE +T + ++ L + + +++ + +
Sbjct: 597 EQLDALEKETASKLSEMDSFNNQLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELM 656
Query: 393 QVQELLDELDEQKAQLEEQL-KEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR 451
Q ++L DE + Q +E L KE +K EE Q L +++Q EEE +
Sbjct: 657 QKKKLEDEAARKAKQGKENLWKENLRKEEEEKQ------KRLQEEKTQEKIQEEE--RKA 708
Query: 452 EELSRLQQETAELEE 466
EE R ++T + EE
Sbjct: 709 EEKQRKDKDTLKAEE 723
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 125 bits (314), Expect = 2e-28
Identities = 131/526 (24%), Positives = 224/526 (42%), Gaps = 52/526 (9%)
Query: 21 KYYRQVDT--GNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
K+ RQ D + G + A F +SGLP +L +IW L+D + G +++QEF +A++
Sbjct: 25 KHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMK 84
Query: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS 138
L+ G ++ + + PP F SPL+ + +P P+ I
Sbjct: 85 LIKLKLQGQQLPVVLPPIMKQPPMF----SPLISARFGMGSMPNLSIPQPLPPAAPITSL 140
Query: 139 LSPVNG-----FLSGDKVKPVLLNSKLP------VDILGRVWELSDIDHD-------GML 180
S +G + + P + S LP + L + S + H G
Sbjct: 141 SSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGF 200
Query: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240
A L+ + P + W V + KY + F DK M
Sbjct: 201 GGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMS 260
Query: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDP- 299
G++SG + R L++ L T LA IW+L D G+L ++F LA HL + K P
Sbjct: 261 GYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTD--MAKAGQPL 318
Query: 300 PHVLTPEMIPPSDRASLQ-KNIIGSSP----VADFSAIKELDTLNNEIVDLQREKNNVEQ 354
P L PE++PPS R Q +I G+ P + + K+L + E+ N+E
Sbjct: 319 PLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMEL 378
Query: 355 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
+ + + +Q+ + Q E + ++LQ Q+ + Q L++ E++ +LE Q +E
Sbjct: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE 438
Query: 415 VRKKCAEEAQLISSLKAELTSQE----SQISTYE--EELAKAREELSRLQQETAELEESV 468
R+K E + + K EL Q +I E + + +EE+ RL + L +
Sbjct: 439 ERRKDIERRE---AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
Query: 469 E---------SGKAQLEPLQQHLQDSQQEISSMQ--MKLMEMKDLE 503
E SG+ Q L++ Q ++ E+ Q +++ME+K L+
Sbjct: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ 541
Score = 93.6 bits (231), Expect = 7e-19
Identities = 112/481 (23%), Positives = 189/481 (39%), Gaps = 92/481 (19%)
Query: 106 TSSPLLISGTS--AAELPWAVKPEDKAKYDAIFDSLSP-VNGFLSGDKVKPVLLNSKLPV 162
TSS +SG S WAV + KY F++L ++G+LSG + + LL S L
Sbjct: 220 TSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ 279
Query: 163 DILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVP----------- 211
L +W L+D+D DG L +EF +AM L A +P+P++LPP LVP
Sbjct: 280 TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDS 339
Query: 212 ---------------PSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTG 256
P K+ KA Y+ ++ +K + + RE K
Sbjct: 340 INGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQ 398
Query: 257 LPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASL 316
W + + K Q L L Q+ ++ E +R
Sbjct: 399 KEK----EEWERKQRELQEQEWKKQLELEKRLEKQRELE-----RQREEERRKDIERREA 449
Query: 317 QKNIIGSSPVADFSAIKELDTLNN------EIVDLQREKNNVEQDLKEKEDTIKQRTSEV 370
K + ++ I+ + LN EIV L +K N+ +L+ +Q + +
Sbjct: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRL 509
Query: 371 QDLQDEVQRENTNLQ--------------KLQAQKQQVQELLDELDEQKAQLEEQLKEVR 416
QD++ + Q + T L+ +LQ + Q+ Q L L +K L E++K ++
Sbjct: 510 QDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
Query: 417 -------------KKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE---------- 453
KK E+ +L LK +L + E + ++ E+ +
Sbjct: 570 FSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSV 629
Query: 454 ----------LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLE 503
L+ L EL E+ + + LE L + +D +EI +++LM+ K LE
Sbjct: 630 LQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLE 689
Query: 504 N 504
+
Sbjct: 690 D 690
Score = 85.9 bits (211), Expect = 2e-16
Identities = 35/91 (38%), Positives = 59/91 (64%)
Query: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
WA+ E++ K+D FD+L P G+++GD+ + L S LP +L +W LSD++ DG +D
Sbjct: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
Query: 182 RDEFAVAMFLVYCALEKEPVPMSLPPALVPP 212
+ EF++AM L+ L+ + +P+ LPP + P
Sbjct: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
Score = 64.7 bits (156), Expect = 4e-10
Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 2/93 (2%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
W ++ E+ K+D F K G+++G + R FL++GLP+ +LA IW+L D GK+
Sbjct: 16 WAITSEERTKHDRQFDNL-KPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPP 310
+ +F++A LI KL +G P VL P M P
Sbjct: 75 DQQEFSIAMKLIKLKL-QGQQLPVVLPPIMKQP 106
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y + + +D +G + A L +S L L IW LAD DG G L +EF +A+
Sbjct: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Query: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAA-----------ELPWAVKPE 127
L A+ G + L +L + PP F I+GT + +LP + +
Sbjct: 308 LTDMAKAGQPLPL-TLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDK 366
Query: 128 DKAKYD 133
KA Y+
Sbjct: 367 RKANYE 372
Score = 34.3 bits (77), Expect = 0.53
Identities = 37/151 (24%), Positives = 67/151 (44%), Gaps = 22/151 (14%)
Query: 330 SAIKELDTLNNEI-------------VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDE 376
S + E+D+ NN++ + L NN+ LKE +T + ++ L
Sbjct: 608 SKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKI 667
Query: 377 VQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQL-KEVRKKCAEEAQLISSLKAELTS 435
+ + +++ + + Q ++L DE + Q +E L KE +K EE Q L
Sbjct: 668 KRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQ------KRLQE 721
Query: 436 QESQISTYEEELAKAREELSRLQQETAELEE 466
+++Q EEE + EE R ++T + EE
Sbjct: 722 EKTQEKIQEEE--RKAEEKQRKDKDTLKAEE 750
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 125 bits (314), Expect = 2e-28
Identities = 131/526 (24%), Positives = 224/526 (42%), Gaps = 52/526 (9%)
Query: 21 KYYRQVDT--GNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
K+ RQ D + G + A F +SGLP +L +IW L+D + G +++QEF +A++
Sbjct: 25 KHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMK 84
Query: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS 138
L+ G ++ + + PP F SPL+ + +P P+ I
Sbjct: 85 LIKLKLQGQQLPVVLPPIMKQPPMF----SPLISARFGMGSMPNLSIPQPLPPAAPITSL 140
Query: 139 LSPVNG-----FLSGDKVKPVLLNSKLP------VDILGRVWELSDIDHD-------GML 180
S +G + + P + S LP + L + S + H G
Sbjct: 141 SSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGF 200
Query: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240
A L+ + P + W V + KY + F DK M
Sbjct: 201 GGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMS 260
Query: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDP- 299
G++SG + R L++ L T LA IW+L D G+L ++F LA HL + K P
Sbjct: 261 GYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTD--MAKAGQPL 318
Query: 300 PHVLTPEMIPPSDRASLQ-KNIIGSSP----VADFSAIKELDTLNNEIVDLQREKNNVEQ 354
P L PE++PPS R Q +I G+ P + + K+L + E+ N+E
Sbjct: 319 PLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMEL 378
Query: 355 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
+ + + +Q+ + Q E + ++LQ Q+ + Q L++ E++ +LE Q +E
Sbjct: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE 438
Query: 415 VRKKCAEEAQLISSLKAELTSQE----SQISTYE--EELAKAREELSRLQQETAELEESV 468
R+K E + + K EL Q +I E + + +EE+ RL + L +
Sbjct: 439 ERRKDIERRE---AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
Query: 469 E---------SGKAQLEPLQQHLQDSQQEISSMQ--MKLMEMKDLE 503
E SG+ Q L++ Q ++ E+ Q +++ME+K L+
Sbjct: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ 541
Score = 93.6 bits (231), Expect = 7e-19
Identities = 112/481 (23%), Positives = 189/481 (39%), Gaps = 92/481 (19%)
Query: 106 TSSPLLISGTS--AAELPWAVKPEDKAKYDAIFDSLSP-VNGFLSGDKVKPVLLNSKLPV 162
TSS +SG S WAV + KY F++L ++G+LSG + + LL S L
Sbjct: 220 TSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ 279
Query: 163 DILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVP----------- 211
L +W L+D+D DG L +EF +AM L A +P+P++LPP LVP
Sbjct: 280 TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDS 339
Query: 212 ---------------PSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTG 256
P K+ KA Y+ ++ +K + + RE K
Sbjct: 340 INGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQ 398
Query: 257 LPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASL 316
W + + K Q L L Q+ ++ E +R
Sbjct: 399 KEK----EEWERKQRELQEQEWKKQLELEKRLEKQRELE-----RQREEERRKDIERREA 449
Query: 317 QKNIIGSSPVADFSAIKELDTLNN------EIVDLQREKNNVEQDLKEKEDTIKQRTSEV 370
K + ++ I+ + LN EIV L +K N+ +L+ +Q + +
Sbjct: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRL 509
Query: 371 QDLQDEVQRENTNLQ--------------KLQAQKQQVQELLDELDEQKAQLEEQLKEVR 416
QD++ + Q + T L+ +LQ + Q+ Q L L +K L E++K ++
Sbjct: 510 QDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
Query: 417 -------------KKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE---------- 453
KK E+ +L LK +L + E + ++ E+ +
Sbjct: 570 FSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSV 629
Query: 454 ----------LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLE 503
L+ L EL E+ + + LE L + +D +EI +++LM+ K LE
Sbjct: 630 LQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLE 689
Query: 504 N 504
+
Sbjct: 690 D 690
Score = 85.9 bits (211), Expect = 2e-16
Identities = 35/91 (38%), Positives = 59/91 (64%)
Query: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
WA+ E++ K+D FD+L P G+++GD+ + L S LP +L +W LSD++ DG +D
Sbjct: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
Query: 182 RDEFAVAMFLVYCALEKEPVPMSLPPALVPP 212
+ EF++AM L+ L+ + +P+ LPP + P
Sbjct: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
Score = 64.7 bits (156), Expect = 4e-10
Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 2/93 (2%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
W ++ E+ K+D F K G+++G + R FL++GLP+ +LA IW+L D GK+
Sbjct: 16 WAITSEERTKHDRQFDNL-KPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPP 310
+ +F++A LI KL +G P VL P M P
Sbjct: 75 DQQEFSIAMKLIKLKL-QGQQLPVVLPPIMKQP 106
Score = 46.2 bits (108), Expect = 1e-04
Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y + + +D +G + A L +S L L IW LAD DG G L +EF +A+
Sbjct: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Query: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAA-----------ELPWAVKPE 127
L A+ G + L +L + PP F I+GT + +LP + +
Sbjct: 308 LTDMAKAGQPLPL-TLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDK 366
Query: 128 DKAKYD 133
KA Y+
Sbjct: 367 RKANYE 372
Score = 34.3 bits (77), Expect = 0.53
Identities = 37/151 (24%), Positives = 67/151 (44%), Gaps = 22/151 (14%)
Query: 330 SAIKELDTLNNEI-------------VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDE 376
S + E+D+ NN++ + L NN+ LKE +T + ++ L
Sbjct: 608 SKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKI 667
Query: 377 VQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQL-KEVRKKCAEEAQLISSLKAELTS 435
+ + +++ + + Q ++L DE + Q +E L KE +K EE Q L
Sbjct: 668 KRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQ------KRLQE 721
Query: 436 QESQISTYEEELAKAREELSRLQQETAELEE 466
+++Q EEE + EE R ++T + EE
Sbjct: 722 EKTQEKIQEEE--RKAEEKQRKDKDTLKAEE 750
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 120 bits (302), Expect = 4e-27
Identities = 143/541 (26%), Positives = 230/541 (42%), Gaps = 42/541 (7%)
Query: 31 TGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS 90
+G + A F +SGLP +L +IW LAD + G +++ EF +A++L+ G ++
Sbjct: 36 SGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLP 95
Query: 91 LSSLNLAVPPPRFHDTSSPLLISGTSAAELPW-AVKPEDKAKYDAIFDSLSPVNGFLSGD 149
S+L + +S+P G A+ P AV P + +SP
Sbjct: 96 -SALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVV--GMSPTLVSSVPT 152
Query: 150 KVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALE-KEPVPMSLPPA 208
P L N PV + L H + + L K S A
Sbjct: 153 AAVPPLANGAPPV-----IQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVA 207
Query: 209 LVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSL 268
VPP W V + + KY ++F DK M G ++G + R I +++ LP LA IW+L
Sbjct: 208 SVPPVAE--WAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNL 265
Query: 269 CDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVAD 328
D GKL+ ++F LA HLI + G P VL PE IPPS R + S ++
Sbjct: 266 SDIDQDGKLTAEEFILAMHLIDVAM-SGQPLPPVLPPEYIPPSFR-----RVRSGSGISV 319
Query: 329 FSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ 388
S+ L E V L+ E+ +E+ L + K+ E +L+ E +R Q L
Sbjct: 320 ISSTSVDQRLPEEPV-LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRR-----QALL 373
Query: 389 AQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
Q+++ QE L +L+ EQ ++ R++ +E + L+ +L Q EEE
Sbjct: 374 EQQRKEQERLAQLER-----AEQERKERERQEQERKRQLELEKQLEKQRELERQREEE-- 426
Query: 449 KAREELSRLQQETAELE--ESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHN 506
R+E+ R + ELE +E + + + L Q++I ++ K K LE
Sbjct: 427 -RRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAK---KKTLEFEL 482
Query: 507 SQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPEL 566
LN H + C L+T E + N+ E + +E H + + S ++
Sbjct: 483 EALN--DKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRI---AEITHLQQQLQESQQM 537
Query: 567 L 567
L
Sbjct: 538 L 538
Score = 82.8 bits (203), Expect = 1e-15
Identities = 34/88 (38%), Positives = 60/88 (68%)
Query: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
WA+ E++AK+D F SL P++GF++GD+ + S LP +L ++W L+D+++DG +D
Sbjct: 15 WAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMD 74
Query: 182 RDEFAVAMFLVYCALEKEPVPMSLPPAL 209
+ EF++AM L+ L+ +P +LPP +
Sbjct: 75 QVEFSIAMKLIKLKLQGYQLPSALPPVM 102
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/90 (36%), Positives = 54/90 (60%), Gaps = 2/90 (2%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
W ++ E+AK+D+ F K + GF++G + R F ++GLP +LA IW+L D + G++
Sbjct: 15 WAITVEERAKHDQQFHSL-KPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRM 73
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEM 307
+ +F++A LI KL +G P L P M
Sbjct: 74 DQVEFSIAMKLIKLKL-QGYQLPSALPPVM 102
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/194 (22%), Positives = 93/194 (47%), Gaps = 17/194 (8%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
+EL+ E + E+ + E++ ++ + Q+L ++ +E ++ L+A+K+
Sbjct: 417 RELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKK 476
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLK-------AELTSQESQISTYEE 445
++ L+ L+++K QLE +L+++R + + Q I S AE+T + Q+ ++
Sbjct: 477 TLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQ 536
Query: 446 ELAK-------AREELSRLQQETAELEESVESGKA--QLEPLQQHLQDSQQEI-SSMQMK 495
L + ++L ++QQ + + V +A E +QHL+D E+ + K
Sbjct: 537 MLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSK 596
Query: 496 LMEMKDLENHNSQL 509
L E+ N +L
Sbjct: 597 LQEIDIFNNQLKEL 610
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y + + D +G + A L +S LP L IW+L+D D G L +EF +A+
Sbjct: 225 YRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMH 284
Query: 79 LVACAQNGLEVSLSSLNLAVPPP--RFHDTSSPLLISGTS 116
L+ A +G + +PP R S +IS TS
Sbjct: 285 LIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTS 324
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/147 (21%), Positives = 70/147 (47%), Gaps = 4/147 (2%)
Query: 343 VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELD 402
++ QRE ++ + KE ++ + Q +++ E Q+L Q+ + QE + L
Sbjct: 413 LEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLK 472
Query: 403 EQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETA 462
+K LE +L+ + K + + ++ LT+Q +I + + E++ LQQ+
Sbjct: 473 AKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQ 532
Query: 463 ELEESVESGKAQLEPLQQHLQDSQQEI 489
E ++ + +L P +Q L D +++
Sbjct: 533 ESQQML----GRLIPEKQILNDQLKQV 555
Score = 42.0 bits (97), Expect = 0.003
Identities = 32/102 (31%), Positives = 56/102 (54%), Gaps = 10/102 (9%)
Query: 330 SAIKELDTLNNEIVDLQREKNNVEQDLKEKE---DTIKQRTSEVQDLQDEVQRENTNLQK 386
S ++E+D NN++ +L RE +N +Q K+K + +KQ+ E + ++ E Q+E +
Sbjct: 595 SKLQEIDIFNNQLKEL-REIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653
Query: 387 LQAQKQQVQELLDELDEQ---KAQLEEQLK---EVRKKCAEE 422
+ KQ ++ + E + Q K EE+LK V+KK EE
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEE 695
Score = 36.2 bits (82), Expect = 0.14
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 24/157 (15%)
Query: 341 EIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLD- 399
E +L R+ + D EKE K + ++ + Q + RE N Q+LQ QK E L
Sbjct: 573 EAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQ 632
Query: 400 --------ELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR 451
EL++QK + + + +E K+ E Q QE + + K
Sbjct: 633 KEQERKIIELEKQKEEAQRRAQERDKQWLEHVQ-----------QEDE----HQRPRKLH 677
Query: 452 EELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQE 488
EE ++E+ + ++ E GK + + L QE
Sbjct: 678 EEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQE 714
Score = 35.4 bits (80), Expect = 0.24
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 23/189 (12%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNL-------- 384
+E+++ N E +++Q L+E + + + E Q L D++++ N
Sbjct: 508 QEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVT 567
Query: 385 --QKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQIST 442
+ L+A++ Q L D+LDE + KE R K +E + ++ EL ++
Sbjct: 568 LKRALEAKELARQHLRDQLDEVE-------KETRSK-LQEIDIFNNQLKELREIHNKQQL 619
Query: 443 YEEELAKAREELSRLQQETAELEESVESGKAQ---LEPLQQHLQDSQQEISSMQ-MKLME 498
+++ +A E L + +QE +E + +AQ E +Q L+ QQE + KL E
Sbjct: 620 QKQKSMEA-ERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHE 678
Query: 499 MKDLENHNS 507
+ L+ S
Sbjct: 679 EEKLKREES 687
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 120 bits (302), Expect = 4e-27
Identities = 143/541 (26%), Positives = 230/541 (42%), Gaps = 42/541 (7%)
Query: 31 TGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS 90
+G + A F +SGLP +L +IW LAD + G +++ EF +A++L+ G ++
Sbjct: 36 SGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLP 95
Query: 91 LSSLNLAVPPPRFHDTSSPLLISGTSAAELPW-AVKPEDKAKYDAIFDSLSPVNGFLSGD 149
S+L + +S+P G A+ P AV P + +SP
Sbjct: 96 -SALPPVMKQQPVAISSAPAFGMGGIASMPPLTAVAPVPMGSIPVV--GMSPTLVSSVPT 152
Query: 150 KVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALE-KEPVPMSLPPA 208
P L N PV + L H + + L K S A
Sbjct: 153 AAVPPLANGAPPV-----IQPLPAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSFDVA 207
Query: 209 LVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSL 268
VPP W V + + KY ++F DK M G ++G + R I +++ LP LA IW+L
Sbjct: 208 SVPPVAE--WAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNL 265
Query: 269 CDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVAD 328
D GKL+ ++F LA HLI + G P VL PE IPPS R + S ++
Sbjct: 266 SDIDQDGKLTAEEFILAMHLIDVAM-SGQPLPPVLPPEYIPPSFR-----RVRSGSGISV 319
Query: 329 FSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ 388
S+ L E V L+ E+ +E+ L + K+ E +L+ E +R Q L
Sbjct: 320 ISSTSVDQRLPEEPV-LEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRR-----QALL 373
Query: 389 AQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
Q+++ QE L +L+ EQ ++ R++ +E + L+ +L Q EEE
Sbjct: 374 EQQRKEQERLAQLER-----AEQERKERERQEQERKRQLELEKQLEKQRELERQREEE-- 426
Query: 449 KAREELSRLQQETAELE--ESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHN 506
R+E+ R + ELE +E + + + L Q++I ++ K K LE
Sbjct: 427 -RRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAK---KKTLEFEL 482
Query: 507 SQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPEL 566
LN H + C L+T E + N+ E + +E H + + S ++
Sbjct: 483 EALN--DKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRI---AEITHLQQQLQESQQM 537
Query: 567 L 567
L
Sbjct: 538 L 538
Score = 82.8 bits (203), Expect = 1e-15
Identities = 34/88 (38%), Positives = 60/88 (68%)
Query: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
WA+ E++AK+D F SL P++GF++GD+ + S LP +L ++W L+D+++DG +D
Sbjct: 15 WAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRMD 74
Query: 182 RDEFAVAMFLVYCALEKEPVPMSLPPAL 209
+ EF++AM L+ L+ +P +LPP +
Sbjct: 75 QVEFSIAMKLIKLKLQGYQLPSALPPVM 102
Score = 65.5 bits (158), Expect = 2e-10
Identities = 33/90 (36%), Positives = 54/90 (60%), Gaps = 2/90 (2%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
W ++ E+AK+D+ F K + GF++G + R F ++GLP +LA IW+L D + G++
Sbjct: 15 WAITVEERAKHDQQFHSL-KPISGFITGDQARNFFFQSGLPQPVLAQIWALADMNNDGRM 73
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEM 307
+ +F++A LI KL +G P L P M
Sbjct: 74 DQVEFSIAMKLIKLKL-QGYQLPSALPPVM 102
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/194 (22%), Positives = 93/194 (47%), Gaps = 17/194 (8%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
+EL+ E + E+ + E++ ++ + Q+L ++ +E ++ L+A+K+
Sbjct: 417 RELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLKAKKK 476
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLK-------AELTSQESQISTYEE 445
++ L+ L+++K QLE +L+++R + + Q I S AE+T + Q+ ++
Sbjct: 477 TLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQESQQ 536
Query: 446 ELAK-------AREELSRLQQETAELEESVESGKA--QLEPLQQHLQDSQQEI-SSMQMK 495
L + ++L ++QQ + + V +A E +QHL+D E+ + K
Sbjct: 537 MLGRLIPEKQILNDQLKQVQQNSLHRDSLVTLKRALEAKELARQHLRDQLDEVEKETRSK 596
Query: 496 LMEMKDLENHNSQL 509
L E+ N +L
Sbjct: 597 LQEIDIFNNQLKEL 610
Score = 46.2 bits (108), Expect = 1e-04
Identities = 30/100 (30%), Positives = 45/100 (45%), Gaps = 2/100 (2%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y + + D +G + A L +S LP L IW+L+D D G L +EF +A+
Sbjct: 225 YRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGKLTAEEFILAMH 284
Query: 79 LVACAQNGLEVSLSSLNLAVPPP--RFHDTSSPLLISGTS 116
L+ A +G + +PP R S +IS TS
Sbjct: 285 LIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTS 324
Score = 45.4 bits (106), Expect = 2e-04
Identities = 32/147 (21%), Positives = 70/147 (47%), Gaps = 4/147 (2%)
Query: 343 VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELD 402
++ QRE ++ + KE ++ + Q +++ E Q+L Q+ + QE + L
Sbjct: 413 LEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNRRQELLNQRNKEQEDIVVLK 472
Query: 403 EQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETA 462
+K LE +L+ + K + + ++ LT+Q +I + + E++ LQQ+
Sbjct: 473 AKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIESTNKSRELRIAEITHLQQQLQ 532
Query: 463 ELEESVESGKAQLEPLQQHLQDSQQEI 489
E ++ + +L P +Q L D +++
Sbjct: 533 ESQQML----GRLIPEKQILNDQLKQV 555
Score = 42.0 bits (97), Expect = 0.003
Identities = 32/102 (31%), Positives = 56/102 (54%), Gaps = 10/102 (9%)
Query: 330 SAIKELDTLNNEIVDLQREKNNVEQDLKEKE---DTIKQRTSEVQDLQDEVQRENTNLQK 386
S ++E+D NN++ +L RE +N +Q K+K + +KQ+ E + ++ E Q+E +
Sbjct: 595 SKLQEIDIFNNQLKEL-REIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQKEEAQRRA 653
Query: 387 LQAQKQQVQELLDELDEQ---KAQLEEQLK---EVRKKCAEE 422
+ KQ ++ + E + Q K EE+LK V+KK EE
Sbjct: 654 QERDKQWLEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEE 695
Score = 36.2 bits (82), Expect = 0.14
Identities = 39/157 (24%), Positives = 65/157 (41%), Gaps = 24/157 (15%)
Query: 341 EIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLD- 399
E +L R+ + D EKE K + ++ + Q + RE N Q+LQ QK E L
Sbjct: 573 EAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLKELREIHNKQQLQKQKSMEAERLKQ 632
Query: 400 --------ELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR 451
EL++QK + + + +E K+ E Q QE + + K
Sbjct: 633 KEQERKIIELEKQKEEAQRRAQERDKQWLEHVQ-----------QEDE----HQRPRKLH 677
Query: 452 EELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQE 488
EE ++E+ + ++ E GK + + L QE
Sbjct: 678 EEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQE 714
Score = 35.4 bits (80), Expect = 0.24
Identities = 45/189 (23%), Positives = 86/189 (45%), Gaps = 23/189 (12%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNL-------- 384
+E+++ N E +++Q L+E + + + E Q L D++++ N
Sbjct: 508 QEIESTNKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVT 567
Query: 385 --QKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQIST 442
+ L+A++ Q L D+LDE + KE R K +E + ++ EL ++
Sbjct: 568 LKRALEAKELARQHLRDQLDEVE-------KETRSK-LQEIDIFNNQLKELREIHNKQQL 619
Query: 443 YEEELAKAREELSRLQQETAELEESVESGKAQ---LEPLQQHLQDSQQEISSMQ-MKLME 498
+++ +A E L + +QE +E + +AQ E +Q L+ QQE + KL E
Sbjct: 620 QKQKSMEA-ERLKQKEQERKIIELEKQKEEAQRRAQERDKQWLEHVQQEDEHQRPRKLHE 678
Query: 499 MKDLENHNS 507
+ L+ S
Sbjct: 679 EEKLKREES 687
>gi|21361462 EH-domain containing 2 [Homo sapiens]
Length = 543
Score = 104 bits (260), Expect = 3e-22
Identities = 51/98 (52%), Positives = 69/98 (70%), Gaps = 1/98 (1%)
Query: 119 ELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDG 178
E W V +DK+KYD IF +L+P +G LSG K K ++ +KLP +LGR+W+LSD+D DG
Sbjct: 441 EAEWVVT-KDKSKYDEIFYNLAPADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDG 499
Query: 179 MLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRK 216
MLD +EFA+A L+ LE +P +LP LVPPSKR+
Sbjct: 500 MLDDEEFALASHLIEAKLEGHGLPANLPRRLVPPSKRR 537
Score = 64.7 bits (156), Expect = 4e-10
Identities = 40/96 (41%), Positives = 55/96 (57%), Gaps = 3/96 (3%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
WVV+ +K+KYDEIF DG +SG + + + T LP+++L IW L D G L
Sbjct: 444 WVVTK-DKSKYDEIFYNL-APADGKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGML 501
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDR 313
++FALA HLI KL +G P L ++PPS R
Sbjct: 502 DDEEFALASHLIEAKL-EGHGLPANLPRRLVPPSKR 536
Score = 44.7 bits (104), Expect = 4e-04
Identities = 22/71 (30%), Positives = 39/71 (54%)
Query: 32 GRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSL 91
G++ S A ++ + LP+ +LG+IW L+D D G+L+ +EF +A L+ G +
Sbjct: 465 GKLSGSKAKTWMVGTKLPNSVLGRIWKLSDVDRDGMLDDEEFALASHLIEAKLEGHGLPA 524
Query: 92 SSLNLAVPPPR 102
+ VPP +
Sbjct: 525 NLPRRLVPPSK 535
>gi|30240932 EH-domain containing 1 [Homo sapiens]
Length = 534
Score = 101 bits (252), Expect = 3e-21
Identities = 49/104 (47%), Positives = 70/104 (67%), Gaps = 1/104 (0%)
Query: 113 SGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELS 172
+G ++ W V +DK YD IF +LSPVNG ++G K ++ SKLP +LG++W+L+
Sbjct: 430 AGEGIDDVEWVVG-KDKPTYDEIFYTLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLA 488
Query: 173 DIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRK 216
D+D DG+LD +EFA+A L+ LE +P LPP LVPPSKR+
Sbjct: 489 DVDKDGLLDDEEFALANHLIKVKLEGHELPADLPPHLVPPSKRR 532
Score = 68.2 bits (165), Expect = 3e-11
Identities = 40/96 (41%), Positives = 57/96 (59%), Gaps = 3/96 (3%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
WVV +K YDEIF T ++G ++G ++ +K+ LP+T+L IW L D G L
Sbjct: 439 WVVGK-DKPTYDEIFY-TLSPVNGKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLL 496
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDR 313
++FALA HLI KL +G + P L P ++PPS R
Sbjct: 497 DDEEFALANHLIKVKL-EGHELPADLPPHLVPPSKR 531
Score = 53.5 bits (127), Expect = 8e-07
Identities = 29/86 (33%), Positives = 47/86 (54%), Gaps = 1/86 (1%)
Query: 17 PVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVA 76
P Y++ + + N G++ ++A + KS LP+ +LGKIW LAD D G+L+ +EF +A
Sbjct: 446 PTYDEIFYTLSPVN-GKITGANAKKEMVKSKLPNTVLGKIWKLADVDKDGLLDDEEFALA 504
Query: 77 LRLVACAQNGLEVSLSSLNLAVPPPR 102
L+ G E+ VPP +
Sbjct: 505 NHLIKVKLEGHELPADLPPHLVPPSK 530
>gi|21264315 EH-domain containing 4 [Homo sapiens]
Length = 541
Score = 99.8 bits (247), Expect = 1e-20
Identities = 50/101 (49%), Positives = 68/101 (67%), Gaps = 1/101 (0%)
Query: 117 AAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDH 176
A E W V +DK YD +F +LSP+NG +SG K ++ SKLP +LG++W+L+D D
Sbjct: 437 ADEEEWVVA-KDKPVYDELFYTLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDC 495
Query: 177 DGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKT 217
DGMLD +EFA+A L+ L+ +P SLPP LVPPS RK+
Sbjct: 496 DGMLDEEEFALAKHLIKIKLDGYELPSSLPPHLVPPSHRKS 536
Score = 70.1 bits (170), Expect = 9e-12
Identities = 41/101 (40%), Positives = 61/101 (60%), Gaps = 3/101 (2%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
WVV+ +K YDE+F T ++G +SG+ ++ + + LP+++L IW L D G L
Sbjct: 442 WVVAK-DKPVYDELFY-TLSPINGKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGML 499
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQK 318
+++FALA HLI KL G + P L P ++PPS R SL K
Sbjct: 500 DEEEFALAKHLIKIKL-DGYELPSSLPPHLVPPSHRKSLPK 539
Score = 52.8 bits (125), Expect = 1e-06
Identities = 30/89 (33%), Positives = 50/89 (56%), Gaps = 1/89 (1%)
Query: 12 LSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQ 71
++ PVY++ + + N G++ +A + S LP+ +LGKIW LAD D G+L+++
Sbjct: 444 VAKDKPVYDELFYTLSPIN-GKISGVNAKKEMVTSKLPNSVLGKIWKLADCDCDGMLDEE 502
Query: 72 EFFVALRLVACAQNGLEVSLSSLNLAVPP 100
EF +A L+ +G E+ S VPP
Sbjct: 503 EFALAKHLIKIKLDGYELPSSLPPHLVPP 531
>gi|7657056 EH-domain containing 3 [Homo sapiens]
Length = 535
Score = 99.0 bits (245), Expect = 2e-20
Identities = 50/104 (48%), Positives = 67/104 (64%), Gaps = 1/104 (0%)
Query: 113 SGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELS 172
+G + W V DK YD IF +LSPV+G ++G K ++ SKLP +LG++W+L+
Sbjct: 430 AGEGIDDAEWVVA-RDKPMYDEIFYTLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLA 488
Query: 173 DIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRK 216
DID DGMLD DEFA+A L+ LE +P LP L+PPSKRK
Sbjct: 489 DIDKDGMLDDDEFALANHLIKVKLEGHELPNELPAHLLPPSKRK 532
Score = 67.4 bits (163), Expect = 6e-11
Identities = 39/96 (40%), Positives = 58/96 (60%), Gaps = 3/96 (3%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
WVV+ +K YDEIF T +DG ++G ++ +++ LP+++L IW L D G L
Sbjct: 439 WVVA-RDKPMYDEIFY-TLSPVDGKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGML 496
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDR 313
D+FALA HLI KL +G + P+ L ++PPS R
Sbjct: 497 DDDEFALANHLIKVKL-EGHELPNELPAHLLPPSKR 531
Score = 47.0 bits (110), Expect = 8e-05
Identities = 26/86 (30%), Positives = 47/86 (54%), Gaps = 1/86 (1%)
Query: 17 PVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVA 76
P+Y++ + + + G++ ++A + +S LP+ +LGKIW LAD D G+L+ EF +A
Sbjct: 446 PMYDEIFYTLSPVD-GKITGANAKKEMVRSKLPNSVLGKIWKLADIDKDGMLDDDEFALA 504
Query: 77 LRLVACAQNGLEVSLSSLNLAVPPPR 102
L+ G E+ +PP +
Sbjct: 505 NHLIKVKLEGHELPNELPAHLLPPSK 530
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 73.2 bits (178), Expect = 1e-12
Identities = 48/186 (25%), Positives = 92/186 (49%), Gaps = 16/186 (8%)
Query: 335 LDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQD----------------EVQ 378
++TL ++I + ++E++ E +D +Q+ + QD E+
Sbjct: 980 INTLKSKISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEII 1039
Query: 379 RENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQES 438
+ + L +K ++Q++L+ + +K QL+ LKE + E + + L EL Q+
Sbjct: 1040 EQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQE 1099
Query: 439 QISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLME 498
++ + K ELSR AE+EE ++ QL+ QQ L + Q+E+S MQ K+ E
Sbjct: 1100 IVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINE 1159
Query: 499 MKDLEN 504
+++L+N
Sbjct: 1160 IENLKN 1165
Score = 61.6 bits (148), Expect = 3e-09
Identities = 42/179 (23%), Positives = 90/179 (50%), Gaps = 17/179 (9%)
Query: 330 SAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQK-LQ 388
S +++ ++ ++ ++ E + + L+E D +K E DLQ LQ+ LQ
Sbjct: 1404 SEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQ--------RLQEVLQ 1455
Query: 389 AQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
++ Q++E + E+ + + EE+LK E+ + I+ L+ L+ +E++IST +++L
Sbjct: 1456 SESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLE 1515
Query: 449 KAREELSRLQQETAELEE--------SVESGKAQLEPLQQHLQDSQQEISSMQMKLMEM 499
++L QE E EE V+ +L+ ++H + + S++ K++E+
Sbjct: 1516 AINDKLQNKIQEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLEL 1574
Score = 60.1 bits (144), Expect = 9e-09
Identities = 47/228 (20%), Positives = 108/228 (47%), Gaps = 18/228 (7%)
Query: 332 IKELDTLNNEIVDLQREKNNVE--------------QDLKEKEDTIKQRTSEVQDLQDEV 377
++E + +N EIV+L +E + Q+L+EK +++R +E++ L++++
Sbjct: 837 LEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQL 896
Query: 378 QRENTNLQKLQAQKQQVQELLDE-LDEQKAQLEEQLKEVRKKCAEEAQL-ISSLKAELTS 435
+ ++ LQ ++ +K + E L + L+E K +E K+ K+ E Q+ LK+++
Sbjct: 897 ENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQE--KDDLKQLQESLQIERDQLKSDIHD 954
Query: 436 QESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMK 495
+ +E+L A E L + Q+ L+ + ++ ++++ +++ E +
Sbjct: 955 TVNMNIDTQEQLRNALESLKQHQETINTLKSKISEEVSRNLHMEENTGETKDEFQQKMVG 1014
Query: 496 LMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHV 543
+ + +DLE N+Q + ++ SL +E + E V
Sbjct: 1015 IDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESV 1062
Score = 59.3 bits (142), Expect = 2e-08
Identities = 40/193 (20%), Positives = 93/193 (48%), Gaps = 17/193 (8%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKED-------------TIKQRTSEVQDLQDEVQRE 380
+L TL ++ + Q++ + +EQ K+ +D + Q+ E + V +E
Sbjct: 1831 QLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890
Query: 381 NTNLQK----LQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQ 436
NL++ L+ ++ Q++E L E + +++++LK R E + + L+ +++ +
Sbjct: 1891 RDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKETVDKLREKISEK 1950
Query: 437 ESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKL 496
QIS +++L K+++EL + QE + E + K + + + + +Q + +
Sbjct: 1951 TIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEMEQLKKQFEAQN 2010
Query: 497 MEMKDLENHNSQL 509
+ M+ + N QL
Sbjct: 2011 LSMQSVRMDNFQL 2023
Score = 56.6 bits (135), Expect = 1e-07
Identities = 38/175 (21%), Positives = 89/175 (50%), Gaps = 11/175 (6%)
Query: 329 FSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ 388
FS I+E + L + + EK ++ DLKE + + E++ L DE++++ + + +
Sbjct: 1046 FSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEK 1105
Query: 389 AQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
+ + L ++ A++EE+LKE ++ E+ Q + +++ E++ + +I+
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKIN------- 1158
Query: 449 KAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLE 503
E+ L+ E E ++E + + L Q L ++ +E+ S+ + +K+L+
Sbjct: 1159 ----EIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209
Score = 55.5 bits (132), Expect = 2e-07
Identities = 53/231 (22%), Positives = 91/231 (39%), Gaps = 12/231 (5%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQ 393
E++ L EI D E + + + + + + S VQ L +E+ + +L Q+ +
Sbjct: 755 EVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKS 814
Query: 394 VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE 453
+ E++ K V ++ Q I +L E +S + + EL+ +E
Sbjct: 815 TDQEFQNFKTLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQE 874
Query: 454 LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQE----ISSMQMKLMEMKDLENHNSQL 509
L +E E +E K QLE LQ ++E +Q L E+K L L
Sbjct: 875 LQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDL 934
Query: 510 NWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQ--SNLESEPIHQES 558
I + L + +T N+N + Q + LES HQE+
Sbjct: 935 KQLQESLQI------ERDQLKSDIHDTVNMNIDTQEQLRNALESLKQHQET 979
Score = 55.1 bits (131), Expect = 3e-07
Identities = 42/176 (23%), Positives = 84/176 (47%), Gaps = 10/176 (5%)
Query: 336 DTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQ 395
D L + + +Q E LKE+++TI + V + D++ +L+ A+ Q+
Sbjct: 1763 DALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKI 1822
Query: 396 ELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAE---LTSQESQISTYEEELAKARE 452
+ L + Q L++ + E +KK +E QL +K + L+ E + ++L + E
Sbjct: 1823 QELKANEHQLITLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLE 1882
Query: 453 ELSRLQQETAELEESVESGKAQLEPLQQHLQDS-------QQEISSMQMKLMEMKD 501
E+ + +E L E+ K + + L++ LQ++ QQE+ + +M E K+
Sbjct: 1883 EMKSVMKERDNLRRVEETLKLERDQLKESLQETKARDLEIQQELKTARMLSKEHKE 1938
Score = 53.5 bits (127), Expect = 8e-07
Identities = 62/290 (21%), Positives = 119/290 (41%), Gaps = 38/290 (13%)
Query: 338 LNNEIVDLQREKNN-VEQ------------DLKEKEDTIKQRTSEVQDLQDEVQRENTNL 384
L +I DLQ+E N VE+ +LK +++ E+QD +E+ +
Sbjct: 718 LEGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEK 777
Query: 385 QKLQAQ----KQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQI 440
KL ++ + +VQ LL+E+ + K L K +E Q +L + E +
Sbjct: 778 DKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNY-KSTDQEFQNFKTLHMDF---EQKY 833
Query: 441 STYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
EE + +E+ L +E + + S+ + K +L Q LQ+ +E+ ++ ++K
Sbjct: 834 KMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQLK 893
Query: 501 D-LENHNSQLNWCSSPHSI----LVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIH 555
+ LEN +S L ++ L + +L+ + L E ++ + + IH
Sbjct: 894 EQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQLKSDIH 953
Query: 556 Q--------ESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKE 597
+ R++ E L E + K+ E+ N H +E
Sbjct: 954 DTVNMNIDTQEQLRNALESL----KQHQETINTLKSKISEEVSRNLHMEE 999
Score = 48.9 bits (115), Expect = 2e-05
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 24/185 (12%)
Query: 345 LQREKNNVEQDLKEKEDTIKQRTSEVQDLQ-------DEVQRENTNLQKLQAQKQQVQE- 396
L +E L+EK I ++T ++ D+Q DE+Q++ LQK + Q +V+E
Sbjct: 1932 LSKEHKETVDKLREK---ISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKED 1988
Query: 397 ------LLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYE-EELAK 449
++E+++ K Q E Q ++ + QL L L +E +I E +EL +
Sbjct: 1989 VNMSHKKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESL--EEIRIVAKERDELRR 2046
Query: 450 AREELS-RLQQETAELEESVESGKA--QLEPLQQHLQDSQQEIS-SMQMKLMEMKDLENH 505
+E L Q A L E + + Q++P ++ L D QQ ++ S++ K +K+L
Sbjct: 2047 IKESLKMERDQFIATLREMIARDRQNHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKR 2106
Query: 506 NSQLN 510
S+++
Sbjct: 2107 YSEMD 2111
Score = 48.5 bits (114), Expect = 3e-05
Identities = 62/290 (21%), Positives = 131/290 (45%), Gaps = 45/290 (15%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKED-----TIKQRTSEVQDLQDEVQRENTNLQKLQ 388
+ D L + L+ EK +E LKEK D ++++T + Q++Q + E +NL+ L
Sbjct: 506 DYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ--LIHEISNLKNLV 563
Query: 389 AQKQQVQELLDELDEQKAQLEEQLKEVRKKCAE--EAQLISSLKAELT----------SQ 436
+ + L+ K +L + ++ KK E ++Q + ++K +L+
Sbjct: 564 KHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPKQM 623
Query: 437 ESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKL 496
+ + E A+ E + L+ E EL+E ++ + ++ +Q Q ++ + +
Sbjct: 624 KQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKKMQ 683
Query: 497 MEM-KDLENHNSQLNWCSSPHSILVNGATD---YCSLSTSSSET---ANLNEHVEGQSNL 549
+++ K+L++ +++ +S L++G C+L T LN+ VE
Sbjct: 684 VDLEKELQSAFNEITKLTS----LIDGKVPKDLLCNLELEGKITDLQKELNKEVE----- 734
Query: 550 ESEPIHQESPARSSPELLPSGV----------TDENEVTTAVTEKVCSEL 589
E+E + +E S + LPS V ++E + T+ +K+ SE+
Sbjct: 735 ENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEV 784
Score = 47.8 bits (112), Expect = 5e-05
Identities = 45/217 (20%), Positives = 97/217 (44%), Gaps = 5/217 (2%)
Query: 335 LDTLNNEIVDLQREKNNVEQDLKEKEDTIK-QRTSEVQDLQDEVQRENTNLQKLQAQKQQ 393
L + +E ++ R DL+ E+T+K +R ++L++ + R+ ++L+
Sbjct: 1670 LTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDLEKQEELKIVHMH 1729
Query: 394 VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE 453
++E + +D+ + + E+ E+ + +LKA+ + ++ L + +E
Sbjct: 1730 LKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQET 1789
Query: 454 LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCS 513
+ +L+ +E + + + + LE LQ+ QE+ + + +L+ +K N +
Sbjct: 1790 IDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKK---V 1846
Query: 514 SPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLE 550
S L D SL+ S E NLN + NLE
Sbjct: 1847 SEMEQLKKQIKDQ-SLTLSKLEIENLNLAQKLHENLE 1882
Score = 47.4 bits (111), Expect = 6e-05
Identities = 34/176 (19%), Positives = 85/176 (48%), Gaps = 9/176 (5%)
Query: 340 NEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDE---VQRENTNLQKLQAQKQQVQE 396
N + + E + L E E+ +K+++ ++Q+ Q + VQ E + +QK + +++
Sbjct: 1106 NHAIKKEGELSRTCDRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQK---KINEIEN 1162
Query: 397 LLDELDEQKAQLEE---QLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE 453
L +EL ++ LE + E+ +K E + + S+ E + ++E E R
Sbjct: 1163 LKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGY 1222
Query: 454 LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQL 509
+ ++ + +E ++ L+ Q+ + + ++ +S +++ +DLE +++L
Sbjct: 1223 IREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKL 1278
Score = 47.4 bits (111), Expect = 6e-05
Identities = 37/185 (20%), Positives = 92/185 (49%), Gaps = 27/185 (14%)
Query: 343 VDLQREKNNVEQDLKEKEDTI-------KQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQ 395
++ Q E V LKE ++TI ++T+E+ ++Q +++ N L+AQ ++Q
Sbjct: 1717 LEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSN---DALKAQDLKIQ 1773
Query: 396 ELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQES-------QISTYEEELA 448
E L + +E + ++R +E+ +S+++ +L + + ++ E +L
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLI 1833
Query: 449 KAREELSRLQQETAELE--------ESVESGKAQLEPLQ--QHLQDSQQEISSMQMKLME 498
+++++ Q++ +E+E +S+ K ++E L Q L ++ +E+ S+ +
Sbjct: 1834 TLKKDVNETQKKVSEMEQLKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKERDN 1893
Query: 499 MKDLE 503
++ +E
Sbjct: 1894 LRRVE 1898
Score = 46.6 bits (109), Expect = 1e-04
Identities = 32/160 (20%), Positives = 86/160 (53%), Gaps = 8/160 (5%)
Query: 353 EQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQL 412
++ + E ++ ++T+++ + QD +++ +T LQ+ + QELL + E ++ +E +
Sbjct: 1248 QETIDELRRSVSEKTAQIINTQD-LEKSHTKLQEEIPVLHEEQELLPNVKEV-SETQETM 1305
Query: 413 KEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGK 472
E+ + S+ A + + +++ E+ +++EE+ L +E L+ E+ +
Sbjct: 1306 NELELLTEQSTTKDSTTLARIEMERLRLN---EKFQESQEEIKSLTKERDNLKTIKEALE 1362
Query: 473 AQLEPLQQHLQDSQ---QEISSMQMKLMEMKDLENHNSQL 509
+ + L++H++++ QE S Q + + MK+ +N +++
Sbjct: 1363 VKHDQLKEHIRETLAKIQESQSKQEQSLNMKEKDNETTKI 1402
Score = 45.4 bits (106), Expect = 2e-04
Identities = 39/203 (19%), Positives = 93/203 (45%), Gaps = 37/203 (18%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQK 391
IK++ + ++ +L++ K + K K+ ++ S++ +L + +Q +Q + +K
Sbjct: 1537 IKQISEVQEKVNELKQFKEH----RKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592
Query: 392 QQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL-------------------ISSLKAE 432
++++ + + L ++ QL+E KE+ K E + I LK +
Sbjct: 1593 EEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQEKMCEIEHLKEQ 1652
Query: 433 LTSQESQISTYEEE-------LAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDS 485
+Q+ + E E L + EE+ + +E +L E+ K + + L+++L+++
Sbjct: 1653 FETQKLNLENIETENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRET 1712
Query: 486 -------QQEISSMQMKLMEMKD 501
Q+E+ + M L E ++
Sbjct: 1713 ITRDLEKQEELKIVHMHLKEHQE 1735
Score = 45.1 bits (105), Expect = 3e-04
Identities = 40/185 (21%), Positives = 99/185 (53%), Gaps = 19/185 (10%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEV--QDL--QDEVQRENTNLQKL 387
++E+ ++ E DL+ +VE+ LK + D +K+ E +DL Q+E++ + +L++
Sbjct: 1678 LEEMRSVTKERDDLR----SVEETLKVERDQLKENLRETITRDLEKQEELKIVHMHLKEH 1733
Query: 388 QAQKQQVQELLDELDEQKAQLEEQLKEVRKKC-AEEAQLISSLK---AELTSQESQISTY 443
Q +++ ++ E + + +++ L+ A++ ++ L+ L Q+ I
Sbjct: 1734 QETIDKLRGIVSEKTNEISNMQKDLEHSNDALKAQDLKIQEELRIAHMHLKEQQETIDKL 1793
Query: 444 EEELAKAREELSRLQQE----TAELEESVESGKA---QLEPLQQHLQDSQQEISSMQMKL 496
+++ ++LS +Q++ A+L+E ++ KA QL L++ + ++Q+++S M+
Sbjct: 1794 RGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQLITLKKDVNETQKKVSEMEQLK 1853
Query: 497 MEMKD 501
++KD
Sbjct: 1854 KQIKD 1858
Score = 44.7 bits (104), Expect = 4e-04
Identities = 50/209 (23%), Positives = 96/209 (45%), Gaps = 37/209 (17%)
Query: 332 IKELDTLNNEIVDLQREKNNVE--------------QDLKEKEDTIKQRTSE---VQDLQ 374
+ E+ NEI +L+ E N E Q L E + +K T E +++LQ
Sbjct: 1150 MSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNENYEEVKSITKERKVLKELQ 1209
Query: 375 DEVQRENTNL----QKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEE-AQLISSL 429
+ E +L ++++A Q +E L + +E + E+R+ +E+ AQ+I++
Sbjct: 1210 KSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEKTAQIINTQ 1269
Query: 430 KAELT----SQESQISTYEEELAKAREELSRLQQETAELE---------ESVESGKAQLE 476
E + +E + E+EL +E+S Q+ ELE +S + ++E
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEME 1329
Query: 477 PLQ--QHLQDSQQEISSMQMKLMEMKDLE 503
L+ + Q+SQ+EI S+ + +K ++
Sbjct: 1330 RLRLNEKFQESQEEIKSLTKERDNLKTIK 1358
Score = 43.5 bits (101), Expect = 9e-04
Identities = 42/192 (21%), Positives = 92/192 (47%), Gaps = 29/192 (15%)
Query: 335 LDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQR--ENTNL-------- 384
+D L +I + + +++++DL + +D ++++ E+Q + ++ R E+ N+
Sbjct: 1940 VDKLREKISEKTIQISDIQKDLDKSKDELQKKIQELQKKELQLLRVKEDVNMSHKKINEM 1999
Query: 385 ----QKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQ- 439
++ +AQ +Q + + + +L E L+E+R A+E + +K L + Q
Sbjct: 2000 EQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIR-IVAKERDELRRIKESLKMERDQF 2058
Query: 440 ISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDS-QQEISSMQMKLME 498
I+T E +A+ R+ V+ K L QQHL +S +++ S ++ L
Sbjct: 2059 IATLREMIARDRQ------------NHQVKPEKRLLSDGQQHLTESLREKCSRIKELLKR 2106
Query: 499 MKDLENHNSQLN 510
++++H LN
Sbjct: 2107 YSEMDDHYECLN 2118
Score = 37.4 bits (85), Expect = 0.063
Identities = 67/291 (23%), Positives = 125/291 (42%), Gaps = 51/291 (17%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEV----QDLQDEVQRENTNLQKLQ 388
KEL+ N+ I LQ + + + L++ ++TI+ +V + ++E++ L K+
Sbjct: 2409 KELEVTNDIIAKLQAKVHESNKCLEKTKETIQVLQDKVALGAKPYKEEIEDLKMKLVKID 2468
Query: 389 AQK-QQVQELLDELDEQKAQLEEQLKEV---------RKKCAEEAQLISSLKAELTS--- 435
+K + +E E+ KA +E Q KEV R + A++ +IS S
Sbjct: 2469 LEKMKNAKEFEKEISATKATVEYQ-KEVIRLLRENLRRSQQAQDTSVISEHTDPQPSNKP 2527
Query: 436 ----------QESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDS 485
Q ++ + E + +E+S+L+Q+ +L + K +L QHL
Sbjct: 2528 LTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQ----KNELLSNNQHL--- 2580
Query: 486 QQEISSMQMKLMEMKDLENH-NSQLNWCSSPHSILVNG-ATDYCSLSTSSSETANLNEHV 543
S ++K + + L+ + Q+ +SP S V G A+ ++ S + NL + V
Sbjct: 2581 -----SNEVKTWKERTLKREAHKQVTCENSPKSPKVTGTASKKKQITPSQCKERNLQDPV 2635
Query: 544 EGQSNLESEPIHQESPARSSPELLPSGVTDEN------EVTTAVTEKVCSE 588
+S + +S ++S P P D + EV A E V S+
Sbjct: 2636 PKES---PKSCFFDSRSKSLPSPHPVRYFDNSSLGLCPEVQNAGAESVDSQ 2683
Score = 35.4 bits (80), Expect = 0.24
Identities = 36/177 (20%), Positives = 81/177 (45%), Gaps = 30/177 (16%)
Query: 344 DLQREKNNVEQD---LKEKEDTIK--QRTSEVQDLQDEVQ--------RENTNLQKLQAQ 390
DL++ ++++ L E+++ + + SE Q+ +E++ +++T L +++ +
Sbjct: 1270 DLEKSHTKLQEEIPVLHEEQELLPNVKEVSETQETMNELELLTEQSTTKDSTTLARIEME 1329
Query: 391 KQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTY-EEELAK 449
+ ++ E E +E++K + K E + ++K L + Q+ + E LAK
Sbjct: 1330 RLRLNEKFQES-------QEEIKSLTK----ERDNLKTIKEALEVKHDQLKEHIRETLAK 1378
Query: 450 AREELSRLQQETAELEESVESGK-----AQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+E S+ +Q E+ E+ K Q +P L + E+ + +L E D
Sbjct: 1379 IQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHD 1435
Score = 30.8 bits (68), Expect = 5.9
Identities = 37/182 (20%), Positives = 84/182 (46%), Gaps = 14/182 (7%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQREN--TNLQKLQAQ 390
K+L+ ++ E EK+ + Q L+EK+ K + ++++L + + T Q+L+A+
Sbjct: 357 KQLEEVSLETRAQAMEKDQLAQLLEEKDLLQKVQNEKIENLTRMLVTSSSLTLQQELKAK 416
Query: 391 -KQQVQELLDELDEQK-AQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
K++V L ++++ K + +Q + +L +L E+ + + + + +
Sbjct: 417 RKRRVTWCLGKINKMKNSNYADQFNIPTNITTKTHKLSINLLREI---DESVCSESDVFS 473
Query: 449 KAREELSRLQQETA-------ELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+ LS ++ A +E + S +A + L + + E M++KL E D
Sbjct: 474 NTLDTLSEIEWNPATKLLNQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKND 533
Query: 502 LE 503
L+
Sbjct: 534 LD 535
>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
sapiens]
Length = 1116
Score = 70.9 bits (172), Expect = 5e-12
Identities = 38/161 (23%), Positives = 90/161 (55%), Gaps = 4/161 (2%)
Query: 345 LQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQ 404
LQ E + + L+EKE + ++T ++QD+ +E + + L+ + ++ L ++
Sbjct: 520 LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK 579
Query: 405 KAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQ----E 460
L+EQL++ K+ + + + SL+A+ T+ ++ ++T EE LA+ + RL++ +
Sbjct: 580 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 639
Query: 461 TAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
E +E +++ K L+ L++ + Q ++S + L+++K+
Sbjct: 640 EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 680
Score = 59.3 bits (142), Expect = 2e-08
Identities = 45/205 (21%), Positives = 96/205 (46%), Gaps = 14/205 (6%)
Query: 304 TPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTI 363
+PEM SDR + I A E+D L + +++ EKN+ ++ + E E +
Sbjct: 730 SPEM---SDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQV 786
Query: 364 KQRTSEVQDLQDEVQRENTNLQK-----------LQAQKQQVQELLDELDEQKAQLEEQL 412
K + +V +L+ + Q E + L QQ+Q+ L + D++ +LEE L
Sbjct: 787 KDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL 846
Query: 413 KEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGK 472
+E + AE +++ ++ T+ E Q+ + K ++EL ++ + + ++S+ +
Sbjct: 847 RESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 906
Query: 473 AQLEPLQQHLQDSQQEISSMQMKLM 497
L L+ + +E+ M+ + +
Sbjct: 907 THLTNLRAERRKHLEEVLEMKQEAL 931
Score = 58.5 bits (140), Expect = 3e-08
Identities = 35/163 (21%), Positives = 84/163 (51%), Gaps = 8/163 (4%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
+E+D ++ DL+ + + ++ DL EKE ++ L ++++ L+ L+
Sbjct: 645 EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI--- 701
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKARE 452
L++ E+ ++E QLK+ + A EA+ + + E +I+ Y++E +KA+
Sbjct: 702 ----ALEQKKEECLKMESQLKKAH-EAALEARASPEMSDRIQHLEREITRYKDESSKAQA 756
Query: 453 ELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMK 495
E+ RL + E+E ++ L++ ++D +++++++ K
Sbjct: 757 EVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 799
Score = 49.3 bits (116), Expect = 2e-05
Identities = 38/192 (19%), Positives = 85/192 (44%), Gaps = 24/192 (12%)
Query: 333 KELDTLNNEIVDLQREKNN-------VEQDLKEKEDTIK----QRTSEVQDLQDEVQREN 381
K++ +L + LQ + N +E+ L EKE TI+ QR + ++ Q+E+
Sbjct: 592 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK 651
Query: 382 TNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQIS 441
+L+ L+ + +Q L E + L+E + ++ + +L+ L ++ +
Sbjct: 652 KDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECL 711
Query: 442 TYEEELAKARE-------------ELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQE 488
E +L KA E + L++E ++ +A+++ L + L++ + E
Sbjct: 712 KMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENE 771
Query: 489 ISSMQMKLMEMK 500
+ K+ E++
Sbjct: 772 KNDKDKKIAELE 783
Score = 48.5 bits (114), Expect = 3e-05
Identities = 38/197 (19%), Positives = 101/197 (51%), Gaps = 26/197 (13%)
Query: 328 DFSAIKELDTLNNEIVDLQREK-NNVEQDLKEKEDTIKQRTSE----VQDLQDEVQRENT 382
D + K L T +++++ K +++E+ L++ E+ I+ S ++ ++E+++
Sbjct: 373 DSAKTKALQT----VIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEV 428
Query: 383 NLQKLQAQKQQVQELLDELDEQKAQLEE----------QLKEVRKKCAEEAQLISSLKAE 432
+ K +V++L +EL ++AQ EE ++ +V+++ + + + +L+ +
Sbjct: 429 YRSHSKFMKNKVEQLKEELSSKEAQWEELKKKAAGLQAEIGQVKQELSRKDTELLALQTK 488
Query: 433 LTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQ-------QHLQDS 485
L + +Q S ++ + +E L+ +Q A L+ V++ + +LE + + +QD
Sbjct: 489 LETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDM 548
Query: 486 QQEISSMQMKLMEMKDL 502
+E + ++ ++KD+
Sbjct: 549 AEEKGTQAGEIHDLKDM 565
Score = 48.5 bits (114), Expect = 3e-05
Identities = 51/273 (18%), Positives = 115/273 (42%), Gaps = 39/273 (14%)
Query: 356 LKEKEDTIKQRTSEVQDLQDEVQRENTN--------------LQKLQAQKQQVQELLDEL 401
++ K+ I ++DL++E+Q +N ++ ++ + ++ +++L
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQL 443
Query: 402 DEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQET 461
E+ + E Q +E++KK A L+AE+ + ++S + EL + +L L +
Sbjct: 444 KEELSSKEAQWEELKKKAA-------GLQAEIGQVKQELSRKDTELLALQTKLETLTNQF 496
Query: 462 AELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNS-QLNWCSSPHSILV 520
++ ++ +E K L +Q Q E+ +++++L E + + N + Q+ +
Sbjct: 497 SDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQA 556
Query: 521 NGATDYCSLSTSSSETAN-LNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTT 579
D + N L + +E NL+ + +E S E + S D T
Sbjct: 557 GEIHDLKDMLDVKERKVNVLQKKIE---NLQEQLRDKEKQMSSLKERVKSLQADTTNTDT 613
Query: 580 AVT-------------EKVCSELDNNRHSKEED 599
A+T E++ + D + K+E+
Sbjct: 614 ALTTLEEALAEKERTIERLKEQRDRDEREKQEE 646
Score = 47.8 bits (112), Expect = 5e-05
Identities = 37/181 (20%), Positives = 83/181 (45%), Gaps = 14/181 (7%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQD------LQDEVQRENTNLQK 386
KEL L + +++ +Q L ++++IK+ +Q +E L +
Sbjct: 279 KELFLLRKTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAE 338
Query: 387 LQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEE 446
+ ++ LL++ +++ + L E++ R + A ++ +L+ + ++S+IS+ E
Sbjct: 339 AEMHVHHLESLLEQKEKENSMLREEMHR-RFENAPDSAKTKALQTVIEMKDSKISSMERG 397
Query: 447 LAKAREELSRLQQETAELEESVESGKAQLEPLQQH-------LQDSQQEISSMQMKLMEM 499
L EE+ L+ A E E Q+E + H ++ ++E+SS + + E+
Sbjct: 398 LRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEELSSKEAQWEEL 457
Query: 500 K 500
K
Sbjct: 458 K 458
Score = 47.8 bits (112), Expect = 5e-05
Identities = 43/187 (22%), Positives = 86/187 (45%), Gaps = 9/187 (4%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
+E T EI DL+ + E+ + + I+ +++D + ++ ++ LQA
Sbjct: 550 EEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 609
Query: 393 QVQELLDELDEQKAQLE---EQLKEVRKKCAEEAQ-LISSLKAELTSQESQISTYEEELA 448
L L+E A+ E E+LKE R + E Q I + K +L + ++S + +L+
Sbjct: 610 NTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS 669
Query: 449 KAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQ 508
+ L L++ + L S ++L+ L+ L+ ++E M+ +L + H +
Sbjct: 670 EKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA-----HEAA 724
Query: 509 LNWCSSP 515
L +SP
Sbjct: 725 LEARASP 731
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/198 (21%), Positives = 96/198 (48%), Gaps = 36/198 (18%)
Query: 332 IKELDTLNNE----IVDLQRE---KNNVEQDLKEKEDTIKQRTSEV-------------- 370
+KE++ N+ I +L+R+ +N +LK KE K++++++
Sbjct: 765 LKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS 824
Query: 371 -QDLQDEVQRENTNLQKLQ-AQKQQVQ------ELLDELDEQKAQLEEQLKEVRKKCAEE 422
Q LQD +++++ +++L+ A ++ VQ +L + + + E+Q++E+ +
Sbjct: 825 SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV 884
Query: 423 AQLISSLKAELTSQESQISTYEEELAKAR-------EELSRLQQETAELEESVESGKAQL 475
Q + S+KA+L+S + ++ E L R EE+ ++QE S + L
Sbjct: 885 KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 944
Query: 476 EPLQQHLQDSQQEISSMQ 493
L + +Q+E+++++
Sbjct: 945 LELSSSKKKTQEEVAALK 962
Score = 41.2 bits (95), Expect = 0.004
Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 15/158 (9%)
Query: 341 EIVDLQREKNNVEQDLKEK-EDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLD 399
E+ L+REK+ + Q LK++ ++ +K +D D + ++N + Q+ + L
Sbjct: 957 EVAALKREKDRLVQQLKQQTQNRMKLMADNYED--DHFKSSHSNQTNHKPSPDQIIQPLL 1014
Query: 400 ELDEQKAQLEEQLKEVRKKCAEEAQLI---SSLKAELTSQESQISTYEEELAK-----AR 451
ELD+ +++L+ + + C + LI + A + Q + +E EL K +
Sbjct: 1015 ELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQ-AAWENELQKMTRGQLQ 1073
Query: 452 EELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEI 489
+EL + +++ AEL+ E A L+ + H D +++
Sbjct: 1074 DELEKGERDNAELQ---EFANAILQQIADHCPDILEQV 1108
Score = 31.2 bits (69), Expect = 4.5
Identities = 21/94 (22%), Positives = 47/94 (50%), Gaps = 14/94 (14%)
Query: 335 LDTLNNEIVDLQREKNNVEQDLKEKEDTI-------KQRTSEVQDLQDEV-------QRE 380
++ + E+ ++ + ++ +Q L EKE + ++ EV +++ E +
Sbjct: 881 MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA 940
Query: 381 NTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
N L +L + K++ QE + L +K +L +QLK+
Sbjct: 941 NIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 974
>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
Length = 1088
Score = 70.9 bits (172), Expect = 5e-12
Identities = 38/161 (23%), Positives = 90/161 (55%), Gaps = 4/161 (2%)
Query: 345 LQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQ 404
LQ E + + L+EKE + ++T ++QD+ +E + + L+ + ++ L ++
Sbjct: 492 LQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKK 551
Query: 405 KAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQ----E 460
L+EQL++ K+ + + + SL+A+ T+ ++ ++T EE LA+ + RL++ +
Sbjct: 552 IENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRD 611
Query: 461 TAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
E +E +++ K L+ L++ + Q ++S + L+++K+
Sbjct: 612 EREKQEEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKE 652
Score = 59.3 bits (142), Expect = 2e-08
Identities = 45/205 (21%), Positives = 96/205 (46%), Gaps = 14/205 (6%)
Query: 304 TPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTI 363
+PEM SDR + I A E+D L + +++ EKN+ ++ + E E +
Sbjct: 702 SPEM---SDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQV 758
Query: 364 KQRTSEVQDLQDEVQRENTNLQK-----------LQAQKQQVQELLDELDEQKAQLEEQL 412
K + +V +L+ + Q E + L QQ+Q+ L + D++ +LEE L
Sbjct: 759 KDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEAL 818
Query: 413 KEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGK 472
+E + AE +++ ++ T+ E Q+ + K ++EL ++ + + ++S+ +
Sbjct: 819 RESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKE 878
Query: 473 AQLEPLQQHLQDSQQEISSMQMKLM 497
L L+ + +E+ M+ + +
Sbjct: 879 THLTNLRAERRKHLEEVLEMKQEAL 903
Score = 58.5 bits (140), Expect = 3e-08
Identities = 35/163 (21%), Positives = 84/163 (51%), Gaps = 8/163 (4%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
+E+D ++ DL+ + + ++ DL EKE ++ L ++++ L+ L+
Sbjct: 617 EEIDNYKKDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEI--- 673
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKARE 452
L++ E+ ++E QLK+ + A EA+ + + E +I+ Y++E +KA+
Sbjct: 674 ----ALEQKKEECLKMESQLKKAH-EAALEARASPEMSDRIQHLEREITRYKDESSKAQA 728
Query: 453 ELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMK 495
E+ RL + E+E ++ L++ ++D +++++++ K
Sbjct: 729 EVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHK 771
Score = 49.3 bits (116), Expect = 2e-05
Identities = 38/192 (19%), Positives = 85/192 (44%), Gaps = 24/192 (12%)
Query: 333 KELDTLNNEIVDLQREKNN-------VEQDLKEKEDTIK----QRTSEVQDLQDEVQREN 381
K++ +L + LQ + N +E+ L EKE TI+ QR + ++ Q+E+
Sbjct: 564 KQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYK 623
Query: 382 TNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQIS 441
+L+ L+ + +Q L E + L+E + ++ + +L+ L ++ +
Sbjct: 624 KDLKDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECL 683
Query: 442 TYEEELAKARE-------------ELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQE 488
E +L KA E + L++E ++ +A+++ L + L++ + E
Sbjct: 684 KMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVDRLLEILKEVENE 743
Query: 489 ISSMQMKLMEMK 500
+ K+ E++
Sbjct: 744 KNDKDKKIAELE 755
Score = 47.8 bits (112), Expect = 5e-05
Identities = 41/177 (23%), Positives = 89/177 (50%), Gaps = 16/177 (9%)
Query: 341 EIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDE 400
E+ + ++ + E + + KE + ++T E +L+ E Q+ Q L A+ + +++LL+
Sbjct: 261 ELTEENFQRLHAEHERQAKELFLLRKTLEEMELRIETQK-----QTLNARDESIKKLLEM 315
Query: 401 LDEQ--KAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQ 458
L + A+ E+ E ++ AE + L++ L +E + S EE+ + R E +
Sbjct: 316 LQSKGLSAKATEEDHERTRRLAEAEMHVHHLESLLEQKEKENSMLREEMHR-RFENAPDS 374
Query: 459 QETAELEESVESGKAQLEPLQQHLQDSQQEIS--------SMQMKLMEMKDLENHNS 507
+T L+ +E +++ +++ L+D ++EI S + + EMK +E + S
Sbjct: 375 AKTKALQTVIEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRS 431
Score = 47.8 bits (112), Expect = 5e-05
Identities = 43/187 (22%), Positives = 86/187 (45%), Gaps = 9/187 (4%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
+E T EI DL+ + E+ + + I+ +++D + ++ ++ LQA
Sbjct: 522 EEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTT 581
Query: 393 QVQELLDELDEQKAQLE---EQLKEVRKKCAEEAQ-LISSLKAELTSQESQISTYEEELA 448
L L+E A+ E E+LKE R + E Q I + K +L + ++S + +L+
Sbjct: 582 NTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKEKVSLLQGDLS 641
Query: 449 KAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQ 508
+ L L++ + L S ++L+ L+ L+ ++E M+ +L + H +
Sbjct: 642 EKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKKA-----HEAA 696
Query: 509 LNWCSSP 515
L +SP
Sbjct: 697 LEARASP 703
Score = 47.4 bits (111), Expect = 6e-05
Identities = 42/198 (21%), Positives = 96/198 (48%), Gaps = 36/198 (18%)
Query: 332 IKELDTLNNE----IVDLQRE---KNNVEQDLKEKEDTIKQRTSEV-------------- 370
+KE++ N+ I +L+R+ +N +LK KE K++++++
Sbjct: 737 LKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRREDNLNDS 796
Query: 371 -QDLQDEVQRENTNLQKLQ-AQKQQVQ------ELLDELDEQKAQLEEQLKEVRKKCAEE 422
Q LQD +++++ +++L+ A ++ VQ +L + + + E+Q++E+ +
Sbjct: 797 SQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLMAMEKV 856
Query: 423 AQLISSLKAELTSQESQISTYEEELAKAR-------EELSRLQQETAELEESVESGKAQL 475
Q + S+KA+L+S + ++ E L R EE+ ++QE S + L
Sbjct: 857 KQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDANIAL 916
Query: 476 EPLQQHLQDSQQEISSMQ 493
L + +Q+E+++++
Sbjct: 917 LELSSSKKKTQEEVAALK 934
Score = 43.1 bits (100), Expect = 0.001
Identities = 25/154 (16%), Positives = 78/154 (50%), Gaps = 7/154 (4%)
Query: 356 LKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEV 415
++ K+ I ++DL++E+Q +N ++++ + ++ ++ ++ +V
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQV 443
Query: 416 RKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQL 475
+++ + + + +L+ +L + +Q S ++ + +E L+ +Q A L+ V++ + +L
Sbjct: 444 KQELSRKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRL 503
Query: 476 EPLQ-------QHLQDSQQEISSMQMKLMEMKDL 502
E + + +QD +E + ++ ++KD+
Sbjct: 504 EEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDM 537
Score = 41.2 bits (95), Expect = 0.004
Identities = 37/158 (23%), Positives = 77/158 (48%), Gaps = 15/158 (9%)
Query: 341 EIVDLQREKNNVEQDLKEK-EDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLD 399
E+ L+REK+ + Q LK++ ++ +K +D D + ++N + Q+ + L
Sbjct: 929 EVAALKREKDRLVQQLKQQTQNRMKLMADNYED--DHFKSSHSNQTNHKPSPDQIIQPLL 986
Query: 400 ELDEQKAQLEEQLKEVRKKCAEEAQLI---SSLKAELTSQESQISTYEEELAK-----AR 451
ELD+ +++L+ + + C + LI + A + Q + +E EL K +
Sbjct: 987 ELDQNRSKLKLYIGHLTTLCHDRDPLILRGLTPPASYNLDDDQ-AAWENELQKMTRGQLQ 1045
Query: 452 EELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEI 489
+EL + +++ AEL+ E A L+ + H D +++
Sbjct: 1046 DELEKGERDNAELQ---EFANAILQQIADHCPDILEQV 1080
Score = 40.8 bits (94), Expect = 0.006
Identities = 58/293 (19%), Positives = 118/293 (40%), Gaps = 48/293 (16%)
Query: 347 REKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKA 406
R E + E ++Q+ E L++E+ R N A+ + +Q +++ D + +
Sbjct: 334 RRLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPD-SAKTKALQTVIEMKDSKIS 392
Query: 407 QLEEQLKEVRKKCAEEAQLISSLKAELTSQES----QISTY-------EEELAKAREELS 455
+E L+++ EE Q++ S A T + Q+ Y + ++ + ++ELS
Sbjct: 393 SMERGLRDLE----EEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELS 448
Query: 456 RLQQETAELEESVESGKAQLEPLQQH---LQDS-----------QQEISSMQMKLMEMKD 501
R E L+ +E+ Q +QH L++S Q E+ +++++L E +
Sbjct: 449 RKDTELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKET 508
Query: 502 LENHNS-QLNWCSSPHSILVNGATDYCSLSTSSSETAN-LNEHVEGQSNLESEPIHQESP 559
+ N + Q+ + D + N L + +E NL+ + +E
Sbjct: 509 MLNKKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIE---NLQEQLRDKEKQ 565
Query: 560 ARSSPELLPSGVTDENEVTTAVT-------------EKVCSELDNNRHSKEED 599
S E + S D TA+T E++ + D + K+E+
Sbjct: 566 MSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEE 618
Score = 31.2 bits (69), Expect = 4.5
Identities = 21/94 (22%), Positives = 47/94 (50%), Gaps = 14/94 (14%)
Query: 335 LDTLNNEIVDLQREKNNVEQDLKEKEDTI-------KQRTSEVQDLQDEV-------QRE 380
++ + E+ ++ + ++ +Q L EKE + ++ EV +++ E +
Sbjct: 853 MEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLEEVLEMKQEALLAAISEKDA 912
Query: 381 NTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
N L +L + K++ QE + L +K +L +QLK+
Sbjct: 913 NIALLELSSSKKKTQEEVAALKREKDRLVQQLKQ 946
>gi|190886435 RALBP1 associated Eps domain containing 1 isoform a
[Homo sapiens]
Length = 795
Score = 70.9 bits (172), Expect = 5e-12
Identities = 45/131 (34%), Positives = 62/131 (47%), Gaps = 11/131 (8%)
Query: 92 SSLNLAVPPPRFHD-TSSPLLISGTSAAEL---------PWAVKPEDKAKYDAIFDSLSP 141
+S L + P D T+ + S T+A E+ PW + E + Y F ++ P
Sbjct: 239 TSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQP 298
Query: 142 -VNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEP 200
+NGF+ G K SKLP+ L +WELSD D DG L DEF A LV
Sbjct: 299 DLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYD 358
Query: 201 VPMSLPPALVP 211
+P LP +L+P
Sbjct: 359 LPEKLPESLMP 369
Score = 62.8 bits (151), Expect = 1e-09
Identities = 47/165 (28%), Positives = 73/165 (44%), Gaps = 18/165 (10%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
W ++ ++ Y F D++GF+ G +E F K+ LP L+HIW L D G L
Sbjct: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
Query: 278 SKDQFALAFHLISQKLIKGID----PPHVLTPEMIPPSDRASL-----QKNIIGSSPVAD 328
+ D+F AFHL+ + G D P L P++I D A + + GS A
Sbjct: 339 TLDEFCAAFHLVVARK-NGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAP 397
Query: 329 FSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDL 373
S + +LN +L + E+ +T +R+S Q L
Sbjct: 398 PSKSPSMPSLNQTWPELNQS--------SEQWETFSERSSSSQTL 434
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 10/102 (9%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y ++ + G + S A F KS LP L L IW+L+D D G L EF A
Sbjct: 289 YVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFH 348
Query: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAEL 120
LV +NG ++ P + ++ P LI +A++
Sbjct: 349 LVVARKNGYDL----------PEKLPESLMPKLIDLEDSADV 380
Score = 45.1 bits (105), Expect = 3e-04
Identities = 52/213 (24%), Positives = 87/213 (40%), Gaps = 41/213 (19%)
Query: 9 LTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSG-LPDLILGKIWDLADTDGKGI 67
LT + Y + D +T +V+ + L ++ LP+ ++ +I +L G
Sbjct: 4 LTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGY 63
Query: 68 LNKQEFFVALRLVACAQNGLEVSLSSLNLA--VPPPRFHDTSSPLLISGTSAAELPWAVK 125
+ +F++AL+LVA AQ+G + + S+N +P PRF A K
Sbjct: 64 FGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRF------------------VASK 105
Query: 126 PEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEF 185
E ++++ A + S S G SG V P P G+V + + HD + R
Sbjct: 106 NEQESRHAASYSSDSENQGSYSG--VIP-------PPPGRGQV-KKGSVSHDTVQPRTS- 154
Query: 186 AVAMFLVYCALEKEPVPMSLPPALVPPSKRKTW 218
A +EP + P PP+ TW
Sbjct: 155 ---------ADAQEPASPVVSPQQSPPTSPHTW 178
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/152 (23%), Positives = 63/152 (41%), Gaps = 6/152 (3%)
Query: 220 VSPAEKAKYDEIFLKTD-KDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLS 278
+S AE+ Y ++F D + V V E+F LP+ ++ I LC G
Sbjct: 6 LSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFG 65
Query: 279 KDQFALAFHLISQKLIKGIDPPHVLTPEMIP--PSDRASLQKNIIGSSPVADFSAIKELD 336
+ QF +A L++ + + P V + + P R KN S A +S+ E
Sbjct: 66 RSQFYIALKLVA--VAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQ 123
Query: 337 TLNNEIVDLQREKNNVEQDLKEKEDTIKQRTS 368
+ ++ + V++ DT++ RTS
Sbjct: 124 GSYSGVIPPPPGRGQVKKG-SVSHDTVQPRTS 154
>gi|190886437 RALBP1 associated Eps domain containing 1 isoform b
[Homo sapiens]
Length = 769
Score = 70.9 bits (172), Expect = 5e-12
Identities = 45/131 (34%), Positives = 62/131 (47%), Gaps = 11/131 (8%)
Query: 92 SSLNLAVPPPRFHD-TSSPLLISGTSAAEL---------PWAVKPEDKAKYDAIFDSLSP 141
+S L + P D T+ + S T+A E+ PW + E + Y F ++ P
Sbjct: 239 TSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQP 298
Query: 142 -VNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEP 200
+NGF+ G K SKLP+ L +WELSD D DG L DEF A LV
Sbjct: 299 DLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYD 358
Query: 201 VPMSLPPALVP 211
+P LP +L+P
Sbjct: 359 LPEKLPESLMP 369
Score = 61.2 bits (147), Expect = 4e-09
Identities = 31/92 (33%), Positives = 47/92 (51%), Gaps = 1/92 (1%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
W ++ ++ Y F D++GF+ G +E F K+ LP L+HIW L D G L
Sbjct: 279 WKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGAL 338
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIP 309
+ D+F AFHL+ + G D P L ++P
Sbjct: 339 TLDEFCAAFHLVVARK-NGYDLPEKLPESLMP 369
Score = 46.6 bits (109), Expect = 1e-04
Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 10/102 (9%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y ++ + G + S A F KS LP L L IW+L+D D G L EF A
Sbjct: 289 YVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFH 348
Query: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAEL 120
LV +NG ++ P + ++ P LI +A++
Sbjct: 349 LVVARKNGYDL----------PEKLPESLMPKLIDLEDSADV 380
Score = 45.1 bits (105), Expect = 3e-04
Identities = 52/213 (24%), Positives = 87/213 (40%), Gaps = 41/213 (19%)
Query: 9 LTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSG-LPDLILGKIWDLADTDGKGI 67
LT + Y + D +T +V+ + L ++ LP+ ++ +I +L G
Sbjct: 4 LTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGY 63
Query: 68 LNKQEFFVALRLVACAQNGLEVSLSSLNLA--VPPPRFHDTSSPLLISGTSAAELPWAVK 125
+ +F++AL+LVA AQ+G + + S+N +P PRF A K
Sbjct: 64 FGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRF------------------VASK 105
Query: 126 PEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEF 185
E ++++ A + S S G SG V P P G+V + + HD + R
Sbjct: 106 NEQESRHAASYSSDSENQGSYSG--VIP-------PPPGRGQV-KKGSVSHDTVQPRTS- 154
Query: 186 AVAMFLVYCALEKEPVPMSLPPALVPPSKRKTW 218
A +EP + P PP+ TW
Sbjct: 155 ---------ADAQEPASPVVSPQQSPPTSPHTW 178
Score = 33.1 bits (74), Expect = 1.2
Identities = 36/152 (23%), Positives = 63/152 (41%), Gaps = 6/152 (3%)
Query: 220 VSPAEKAKYDEIFLKTD-KDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLS 278
+S AE+ Y ++F D + V V E+F LP+ ++ I LC G
Sbjct: 6 LSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFG 65
Query: 279 KDQFALAFHLISQKLIKGIDPPHVLTPEMIP--PSDRASLQKNIIGSSPVADFSAIKELD 336
+ QF +A L++ + + P V + + P R KN S A +S+ E
Sbjct: 66 RSQFYIALKLVA--VAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQ 123
Query: 337 TLNNEIVDLQREKNNVEQDLKEKEDTIKQRTS 368
+ ++ + V++ DT++ RTS
Sbjct: 124 GSYSGVIPPPPGRGQVKKG-SVSHDTVQPRTS 154
>gi|24308179 CTTNBP2 N-terminal like [Homo sapiens]
Length = 639
Score = 68.6 bits (166), Expect = 3e-11
Identities = 48/216 (22%), Positives = 103/216 (47%), Gaps = 8/216 (3%)
Query: 342 IVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDEL 401
I+DL+ E+ QD E +D E + L +++ E + ++K + +++++ L+E
Sbjct: 112 ILDLEEERQRHAQDTAEGDDVTYMLEKERERLTQQLEFEKSQVKKFEKEQKKLSSQLEEE 171
Query: 402 DEQKAQLEEQL----KEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR----EE 453
+ QL L K+ K AEE Q L +L ++S++S EEELA R +
Sbjct: 172 RSRHKQLSSMLVLECKKATNKAAEEGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQT 231
Query: 454 LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCS 513
++++++ +E + E +A+L + + ++E+ S++ + +++ H+S
Sbjct: 232 EAQVEKQLSEFDIEREQLRAKLNREENRTKTLKEEMESLKKIVKDLEASHQHSSPNEQLK 291
Query: 514 SPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNL 549
P ++ AT+ L + +T + SN+
Sbjct: 292 KPVTVSKGTATEPLMLMSVFCQTESFPAERTHGSNI 327
Score = 31.2 bits (69), Expect = 4.5
Identities = 56/249 (22%), Positives = 102/249 (40%), Gaps = 27/249 (10%)
Query: 352 VEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQK-LQAQKQQVQELLDELDEQKAQLEE 410
+E +L+ ++ I+ ++ +D E + N+ L A ++ + L ++ D +K +
Sbjct: 18 LEGELEARDLVIEALKAQHRDTFIEERYGKYNISDPLMALQRDFETLKEKNDGEKQPVCT 77
Query: 411 Q----LKEVRKKCAE-EAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELE 465
LK V K+C + +++S L A S + + + EE R Q+TAE +
Sbjct: 78 NPLSILKVVMKQCKNMQERMLSQLAA-------AESRHRKVILDLEEERQRHAQDTAEGD 130
Query: 466 ESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATD 525
+ + + E L Q L+ + ++ + K+ + +SQL S H L +
Sbjct: 131 DVTYMLEKERERLTQQLEFEKSQVKKFE------KEQKKLSSQLEEERSRHKQLSSMLVL 184
Query: 526 YCSLSTSSSETANLNEHVEGQSNLE-SEPIHQESPARSSPELLPSGVTDENEVTTAVTEK 584
C +T+ + EGQ E S + +E S E + T A EK
Sbjct: 185 ECKKATNKAAE-------EGQKAGELSLKLEKEKSRVSKLEEELAAERKRGLQTEAQVEK 237
Query: 585 VCSELDNNR 593
SE D R
Sbjct: 238 QLSEFDIER 246
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 67.4 bits (163), Expect = 6e-11
Identities = 64/258 (24%), Positives = 116/258 (44%), Gaps = 32/258 (12%)
Query: 345 LQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQ 404
LQ EK ++Q+++E E+ +++ S Q LQ E L+KL+ ++ +++ +L ++
Sbjct: 934 LQAEKKKMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKE 993
Query: 405 KAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEEL---AKAREELSR----- 456
K LE+++ E EE + SL E+ I+ EE L K R+EL +
Sbjct: 994 KKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKL 1053
Query: 457 ------LQQETAELEESVESGKAQL----EPLQQHLQDSQQEISSMQMKLMEMKDLENHN 506
L + AEL+ + K QL E LQ L ++E + M L ++++LE+
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113
Query: 507 SQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEG-----QSNLESEPIHQESPAR 561
S+L + ++ S + + + +L E +E + L+S QE ++
Sbjct: 1114 SELQ---------EDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSK 1164
Query: 562 SSPELLPSGVTDENEVTT 579
E+ T E E T
Sbjct: 1165 REQEVNILKKTLEEEAKT 1182
Score = 65.1 bits (157), Expect = 3e-10
Identities = 63/323 (19%), Positives = 135/323 (41%), Gaps = 41/323 (12%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
KE L + I + E+ K + + + DL++ ++RE Q+L+ ++
Sbjct: 992 KEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNKHEAMITDLEERLRREEKQRQELEKTRR 1051
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQ--------------ES 438
+++ +L +Q A+L+ Q+ E++ + A++ + + + A + + ES
Sbjct: 1052 KLEGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELES 1111
Query: 439 QISTYEEELAKAREELSRLQQETAELEESVESGKAQLE------PLQQHLQDSQQEISSM 492
QIS +E+L R ++ +++ +L E +E+ K +LE QQ L+ +++ ++
Sbjct: 1112 QISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI 1171
Query: 493 QMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYC------------SLSTSSSETANLN 540
K +E ++ + H +Q+ HS V + + T +E L
Sbjct: 1172 LKKTLE-EEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELA 1230
Query: 541 EHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCS---ELDN-----N 592
V+ + + H+ + + L + V T + +KV ELDN +
Sbjct: 1231 NEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLS 1290
Query: 593 RHSKEEDPFNVDSSSLTGPVADT 615
+ + D S+L + DT
Sbjct: 1291 QSDSKSSKLTKDFSALESQLQDT 1313
Score = 63.2 bits (152), Expect = 1e-09
Identities = 35/174 (20%), Positives = 92/174 (52%), Gaps = 8/174 (4%)
Query: 336 DTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQ 395
D + + +L++ K +EQ ++E + +++ E+Q +D R NLQ ++AQ ++
Sbjct: 1514 DDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDL 1573
Query: 396 ELLDELDEQKA--------QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEEL 447
+ DE E+K ++E +L++ RK+ + L+ +L E+ I + +
Sbjct: 1574 QGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNR 1633
Query: 448 AKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+A ++L +LQ + + ++ +A E + +++++++ SM+ +++++++
Sbjct: 1634 DEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQE 1687
Score = 57.4 bits (137), Expect = 6e-08
Identities = 61/274 (22%), Positives = 116/274 (42%), Gaps = 49/274 (17%)
Query: 272 KDCGKLSKDQFALAFHLISQ-----KLIKGIDPPHVLTPEMIPPSDRASLQK-------- 318
KDC + D A +++Q K +K ++ + E + ++RA Q
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELA 1707
Query: 319 NIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQ 378
+ I +S A++E L I L+ E + + + D +K+ ++ + ++
Sbjct: 1708 DEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLN 1767
Query: 379 RENTNLQKLQAQKQQVQ----ELLDELDEQK------------------AQLEEQL---- 412
E ++ QK + +QQ++ EL +L E + AQLEEQL
Sbjct: 1768 LERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQLEEQLDNET 1827
Query: 413 KEVRKKCAEEAQLISSLK---AELTSQESQISTYEEELAKAREELSRLQQETAELEESVE 469
KE + C + + LK ++ + Y+++ KA L +L+++ E EE +
Sbjct: 1828 KERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAEEEAQ 1887
Query: 470 SGKAQLEPLQQHLQDSQQ-------EISSMQMKL 496
A LQ+ L+D+ + E+SS++ KL
Sbjct: 1888 RANASRRKLQRELEDATETADAMNREVSSLKNKL 1921
Score = 56.2 bits (134), Expect = 1e-07
Identities = 56/262 (21%), Positives = 120/262 (45%), Gaps = 34/262 (12%)
Query: 331 AIKELDTLNNEIVDLQRE-------KNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTN 383
A+K++ L ++I +LQ + +N E+ ++ + ++ +E++D D +
Sbjct: 1102 ALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQ--- 1158
Query: 384 LQKLQAQKQQVQELLDELDEQKAQLEE-QLKEVRKK----CAEEAQLISSLKAELTSQES 438
Q+L+++++Q +L + E++A+ E Q++E+R+K E A+ + K + E
Sbjct: 1159 -QELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEK 1217
Query: 439 QISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLME 498
T E E + E+ L Q + E + +AQL+ LQ + ++ + + K+ +
Sbjct: 1218 AKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTK 1277
Query: 499 MK-DLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNE--------------HV 543
++ +L+N L+ S S L D+ +L + +T L + V
Sbjct: 1278 LQVELDNVTGLLSQSDSKSSKLTK---DFSALESQLQDTQELLQEENRQKLSLSTKLKQV 1334
Query: 544 EGQSNLESEPIHQESPARSSPE 565
E + N E + +E A+ + E
Sbjct: 1335 EDEKNSFREQLEEEEEAKHNLE 1356
Score = 53.9 bits (128), Expect = 6e-07
Identities = 43/179 (24%), Positives = 86/179 (48%), Gaps = 8/179 (4%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQ---DEVQRENTNL----Q 385
K TL NE +L E + Q + E K+ +++Q+LQ +E +R T L
Sbjct: 1217 KAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVT 1276
Query: 386 KLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEE 445
KLQ + V LL + D + ++L + + + + +L+ + S +++ E+
Sbjct: 1277 KLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVED 1336
Query: 446 ELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEI-SSMQMKLMEMKDLE 503
E RE+L ++ LE+ + + AQ+ +++ ++DS + ++ ++K KDLE
Sbjct: 1337 EKNSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLE 1395
Score = 53.5 bits (127), Expect = 8e-07
Identities = 63/291 (21%), Positives = 127/291 (43%), Gaps = 50/291 (17%)
Query: 267 SLCDTKDCGKLSKDQFALAFHLI-SQKLIKGIDPPHV-LTPEMIPPSDRASLQKNIIGSS 324
S D+K KL+KD AL L +Q+L++ + + L+ ++ D + + +
Sbjct: 1290 SQSDSKS-SKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEE 1348
Query: 325 PVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNL 384
A + K++ TL+ ++ D++++ + L+ E+ ++ +++ L + +
Sbjct: 1349 EEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAY 1408
Query: 385 QKLQAQKQQVQELLD----ELDEQK---AQLEEQLKEVRKKCAEEAQLISSL-------- 429
KL+ K ++Q+ LD +LD Q+ LE++ K+ + AEE + +
Sbjct: 1409 DKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAE 1468
Query: 430 -----------------------KAELTSQESQISTYEEELAKAREELSR----LQQETA 462
KAEL Q T E+L +++++ + L++
Sbjct: 1469 AEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKR 1528
Query: 463 ELEESVESGKAQLEPLQQHLQDSQQ-----EISSMQMKLMEMKDLENHNSQ 508
LE+ VE K QLE L+ LQ ++ E++ MK +DL+ + Q
Sbjct: 1529 ALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQ 1579
Score = 51.6 bits (122), Expect = 3e-06
Identities = 53/250 (21%), Positives = 112/250 (44%), Gaps = 18/250 (7%)
Query: 363 IKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEE 422
+ ++ E+ ++E+ + + + +++ L +L +K QL+EQL+ + CAE
Sbjct: 840 VSRQEEEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEA 899
Query: 423 AQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHL 482
+L + L A+ E E + + E LQ E +++++++ + QLE +
Sbjct: 900 EELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESAR 959
Query: 483 QDSQQEISSMQMKLMEMKD----LENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETAN 538
Q Q E + + KL ++++ LE+ N +L + +L + ++ + T E +
Sbjct: 960 QKLQLEKVTTEAKLKKLEEEQIILEDQNCKL---AKEKKLLEDRIAEFTTNLTEEEEKSK 1016
Query: 539 -----LNEHVEGQSNLESEPIHQESPARSSPE----LLPSGVTDENEVTTAVTEKVCSEL 589
N+H ++LE E + +E R E L TD ++ + ++ +EL
Sbjct: 1017 SLAKLKNKHEAMITDLE-ERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI-AEL 1074
Query: 590 DNNRHSKEED 599
KEE+
Sbjct: 1075 KMQLAKKEEE 1084
Score = 51.6 bits (122), Expect = 3e-06
Identities = 32/168 (19%), Positives = 82/168 (48%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
++L+ +L++ K +E + E + +K D + + ++ LQ+LQ +
Sbjct: 1203 EQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQVKFN 1262
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKARE 452
+ + + EL ++ +L+ +L V ++ S L + ++ ESQ+ +E L +
Sbjct: 1263 EGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENR 1322
Query: 453 ELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
+ L + ++E+ S + QLE ++ + +++I+++ ++ +MK
Sbjct: 1323 QKLSLSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVADMK 1370
Score = 50.8 bits (120), Expect = 5e-06
Identities = 43/186 (23%), Positives = 83/186 (44%), Gaps = 21/186 (11%)
Query: 338 LNNEIVDLQREKNNVEQDLKEKEDTIKQRT-------SEVQDLQDEVQREN-------TN 383
L +++ LQ E +NV L + + + T S++QD Q+ +Q EN T
Sbjct: 1271 LADKVTKLQVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTK 1330
Query: 384 LQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTY 443
L++++ +K +E L+E +E K LE+Q+ + + A+ +K ++ + T
Sbjct: 1331 LKQVEDEKNSFREQLEEEEEAKHNLEKQIATLHAQVAD-------MKKKMEDSVGCLETA 1383
Query: 444 EEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLE 503
EE K +++L L Q E + + + LQQ L D ++ + ++ +
Sbjct: 1384 EEVKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQ 1443
Query: 504 NHNSQL 509
QL
Sbjct: 1444 KKFDQL 1449
Score = 50.4 bits (119), Expect = 7e-06
Identities = 47/194 (24%), Positives = 86/194 (44%), Gaps = 20/194 (10%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQK 391
++++ + E+ D +++++ K+ E +K + + L+KLQAQ
Sbjct: 1588 VRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQM 1647
Query: 392 QQVQELLDELDEQKAQLEEQLKEVRKKC-AEEAQLISSLKAELTSQE---SQISTYEEEL 447
+ LD+ + ++ Q KE KK + EA++I L+ EL + E Q +EL
Sbjct: 1648 KDCMRELDDTRASREEILAQAKENEKKLKSMEAEMI-QLQEELAAAERAKRQAQQERDEL 1706
Query: 448 AK-----------AREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKL 496
A A EE RL+ A+LEE +E + E + L+ + +I + L
Sbjct: 1707 ADEIANSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDL 1766
Query: 497 MEMKDLENHNSQLN 510
+LE ++Q N
Sbjct: 1767 ----NLERSHAQKN 1776
Score = 50.1 bits (118), Expect = 9e-06
Identities = 47/218 (21%), Positives = 101/218 (46%), Gaps = 22/218 (10%)
Query: 313 RASLQKNIIGSSP-----VADFSAIKELDT-----LNNEIVDLQREKN---NVEQDLKEK 359
+ LQK++ G S VA + +++ T L++ +VDL ++ N+E+ K+
Sbjct: 1387 KRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKF 1446
Query: 360 EDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKC 419
+ + + + +E R ++ + + + L+E EQKA+LE K+ R +
Sbjct: 1447 DQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEM 1506
Query: 420 AE-------EAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGK 472
+ + + L+ + E Q+ + +L + +EL + LE ++++ K
Sbjct: 1507 EDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMK 1566
Query: 473 AQLE-PLQQHLQDSQQEISSMQMKLMEMK-DLENHNSQ 508
AQ E LQ + S+++ + ++ EM+ +LE+ Q
Sbjct: 1567 AQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQ 1604
Score = 47.4 bits (111), Expect = 6e-05
Identities = 45/208 (21%), Positives = 96/208 (46%), Gaps = 40/208 (19%)
Query: 343 VDLQREKNNVEQDLK----EKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQ--- 395
V+LQ K E+DL+ + E+ KQ +V++++ E++ E A +++++
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDL 1619
Query: 396 ---------------ELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKA---ELTSQE 437
E + +L + +AQ+++ ++E+ A ++++ K +L S E
Sbjct: 1620 KDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSME 1679
Query: 438 SQISTYEEELAKAREELSRLQQETAELEESV--ESGK------------AQLEPLQQHLQ 483
+++ +EELA A + QQE EL + + SGK A++ L++ L+
Sbjct: 1680 AEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALEEKRRLEARIAQLEEELE 1739
Query: 484 DSQQEISSMQMKLMEMK-DLENHNSQLN 510
+ Q + +L + ++ N+ LN
Sbjct: 1740 EEQGNTELINDRLKKANLQIDQINTDLN 1767
Score = 46.6 bits (109), Expect = 1e-04
Identities = 38/177 (21%), Positives = 82/177 (46%), Gaps = 14/177 (7%)
Query: 329 FSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ 388
F+ +K L ++ + ++ ++ + + ++EK+ + R +E++ LQ + L
Sbjct: 831 FTKVKPLLQVSRQEEEMMAKEEELVK-VREKQLAAENRLTEMETLQSQ----------LM 879
Query: 389 AQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
A+K Q+QE L E A+ EE + K E ++ L+A + +E + + E
Sbjct: 880 AEKLQLQEQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKK 939
Query: 449 KAREELSRLQQETAELE---ESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDL 502
K ++ + L+++ E E + ++ K E + L++ Q + KL + K L
Sbjct: 940 KMQQNIQELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKL 996
Score = 41.6 bits (96), Expect = 0.003
Identities = 31/174 (17%), Positives = 83/174 (47%), Gaps = 13/174 (7%)
Query: 312 DRASLQKNIIGSSPVADFSAIKELDTLNNEI-VDLQREKNNVEQDLKEKEDTIKQRTSEV 370
D+ + N+ S + +A ++L+ N E+ V LQ + V+ K ++ + +++
Sbjct: 1760 DQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITALEAKIAQL 1819
Query: 371 QD-LQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSL 429
++ L +E + ++++ +++++++L ++D+++ E+ + K QL
Sbjct: 1820 EEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQL---- 1875
Query: 430 KAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQ 483
+ Q+ EEE +A +LQ+E + E+ ++ ++ L+ L+
Sbjct: 1876 -------KRQLEEAEEEAQRANASRRKLQRELEDATETADAMNREVSSLKNKLR 1922
Score = 38.9 bits (89), Expect = 0.022
Identities = 37/189 (19%), Positives = 79/189 (41%), Gaps = 15/189 (7%)
Query: 312 DRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQ 371
D L+ +I ++ D AIK+L L ++ D RE +DT R +
Sbjct: 1618 DLKDLEAHIDSANKNRD-EAIKQLRKLQAQMKDCMREL----------DDTRASR----E 1662
Query: 372 DLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKA 431
++ + + L+ ++A+ Q+QE L + K Q +++ E+ + A + +
Sbjct: 1663 EILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE 1722
Query: 432 ELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISS 491
E E++I+ EEEL + + + + ++ L + H Q ++
Sbjct: 1723 EKRRLEARIAQLEEELEEEQGNTELINDRLKKANLQIDQINTDLNLERSHAQKNENARQQ 1782
Query: 492 MQMKLMEMK 500
++ + E+K
Sbjct: 1783 LERQNKELK 1791
>gi|125625322 RALBP1 associated Eps domain containing 2 isoform 2
[Homo sapiens]
Length = 659
Score = 66.6 bits (161), Expect = 1e-10
Identities = 82/366 (22%), Positives = 143/366 (39%), Gaps = 59/366 (16%)
Query: 31 TGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS 90
T A A + S LP L +I +L G +F++AL+L+A AQ+GL V
Sbjct: 67 TATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVR 126
Query: 91 LSSLNLAVPPPRFHDTSS--------PLLISGTSAAELPWAV-------KPEDKAKYDAI 135
+ S+ +P PRF + + P + GT ++P+ + +D+ K +
Sbjct: 127 IESIKCELPLPRFMMSKNDGEIRFGNPAELHGTKV-QIPYLTTEKNSFKRMDDEDKQETQ 185
Query: 136 FDSLSPV----------------NGFL----SGDKVKPVLLNSKLPVDILGRVWELSDID 175
++SP+ +G+ S +++ P ++ P+ +
Sbjct: 186 SPTMSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLV------QPEGSS 239
Query: 176 HDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKT 235
G + A + ++E+E S P + W ++ ++ Y F
Sbjct: 240 SGGPGTKPLRHQASLIRSFSVERELQDNSSYPD-------EPWRITEEQREYYVNQFRSL 292
Query: 236 DKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIK 295
D F+SG + F K+ L L++IW L D G L+ +F AFHLI +
Sbjct: 293 QPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFHLIVARK-N 351
Query: 296 GIDPPHVLTPEMIPPSDRASLQKNIIGSSPVAD---FSAIKELDTLNNEIVDLQREKNNV 352
G P L P + P +A+ K P D F + E N + DL R +
Sbjct: 352 GYPLPEGLPPTLQPEYLQAAFPK------PKWDCQLFDSYSESLPANQQPRDLNRMEKTS 405
Query: 353 EQDLKE 358
+D+ +
Sbjct: 406 VKDMAD 411
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/155 (24%), Positives = 55/155 (35%), Gaps = 9/155 (5%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y +R + + + S A F KS L L IW+L+D D G L EF A
Sbjct: 285 YVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFH 344
Query: 79 LVACAQNGL--------EVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKA 130
L+ +NG + L A P P++ A + P + +K
Sbjct: 345 LIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKT 404
Query: 131 KYDAIFDSLSPVNGFLSGDK-VKPVLLNSKLPVDI 164
+ D P S DK +N LP D+
Sbjct: 405 SVKDMADLPVPNQDVTSDDKQALKSTINEALPKDV 439
Score = 31.2 bits (69), Expect = 4.5
Identities = 51/214 (23%), Positives = 81/214 (37%), Gaps = 16/214 (7%)
Query: 248 VREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEM 307
V ++F + LP+ L I LC K G QF +A LI+ G+ P + + +
Sbjct: 75 VADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQ-SGL-PVRIESIKC 132
Query: 308 IPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNV----EQDLKEKEDTI 363
P R + KN F EL +I L EKN+ ++D +E +
Sbjct: 133 ELPLPRFMMSKN----DGEIRFGNPAELHGTKVQIPYLTTEKNSFKRMDDEDKQETQSPT 188
Query: 364 KQRTSEVQDLQDEVQRE--NTNLQKLQAQKQQVQELLDELDEQKAQLEEQLK--EVRKKC 419
+ QR + KL++ +Q+ E + Q E K
Sbjct: 189 MSPLASPPSSPPHYQRVPLSHGYSKLRSSAEQMHPAPYEARQPLVQPEGSSSGGPGTKPL 248
Query: 420 AEEAQLISSLKAELTSQESQISTYEEELAKAREE 453
+A LI S E Q++ S+Y +E + EE
Sbjct: 249 RHQASLIRSFSVERELQDN--SSYPDEPWRITEE 280
Score = 30.4 bits (67), Expect = 7.7
Identities = 29/130 (22%), Positives = 49/130 (37%), Gaps = 20/130 (15%)
Query: 771 LPPKIGTPTRPCP-----------LPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKD 819
LPP P RPCP LP R+ ++ P K + + P ++
Sbjct: 511 LPPPPALPPRPCPSQSEQVSEAELLPQLSRAPSQAAESSPAKKDVLYSQPPSKPIRRKFR 570
Query: 820 PEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKR------ESEREEEQRLAR 873
PE + T + + P++ A +P+ + K+ +E LAR
Sbjct: 571 PE---NQATENQEPSTAASGPASAATMKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLAR 627
Query: 874 LNQQEQEDLE 883
LN + Q+ L+
Sbjct: 628 LNSELQQQLK 637
>gi|30089940 Golgi autoantigen, golgin subfamily a, 3 [Homo sapiens]
Length = 1498
Score = 66.6 bits (161), Expect = 1e-10
Identities = 46/198 (23%), Positives = 93/198 (46%)
Query: 303 LTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDT 362
L ++ S + Q SS S E+DTL DL+R +++ L+ K +
Sbjct: 438 LQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNAS 497
Query: 363 IKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEE 422
+ +++Q +++ QR ++ +Q + +L +Q L+ QL++V+ +
Sbjct: 498 LASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTL 557
Query: 423 AQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHL 482
+ + +AE++S +S Y+++LA A+E RLQ E A ++ + LE L+
Sbjct: 558 TSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEHLKLEN 617
Query: 483 QDSQQEISSMQMKLMEMK 500
Q+++ Q + M+ K
Sbjct: 618 VSLSQQLTETQHRSMKEK 635
Score = 62.8 bits (151), Expect = 1e-09
Identities = 42/149 (28%), Positives = 70/149 (46%), Gaps = 7/149 (4%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQREN-------TNLQK 386
EL L E++ + EK E +L + Q + DL+ +Q T+LQ
Sbjct: 879 ELKELRQELMQVHGEKRTAEAELSRLHREVAQVRQHMADLEGHLQSAQKERDEMETHLQS 938
Query: 387 LQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEE 446
LQ K+Q+ + + + K Q+EE +E RK E+ Q + L ++LTS + ++ T +
Sbjct: 939 LQFDKEQMVAVTEANEALKKQIEELQQEARKAITEQKQKMRRLGSDLTSAQKEMKTKHKA 998
Query: 447 LAKAREELSRLQQETAELEESVESGKAQL 475
A LSR QE +E+ ++ QL
Sbjct: 999 YENAVGILSRRLQEALAAKEAADAELGQL 1027
Score = 60.1 bits (144), Expect = 9e-09
Identities = 32/152 (21%), Positives = 76/152 (50%)
Query: 349 KNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQL 408
K +++ + E+ ++ + ++ L++E+ ++ ++ LQ + +++ + ++ EQ Q
Sbjct: 789 KEELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQ 848
Query: 409 EEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESV 468
+ ++ R+ + QLIS LKA +S++ +EL + E + E + L V
Sbjct: 849 KVMVEAYRRDATSKDQLISELKATRKRLDSELKELRQELMQVHGEKRTAEAELSRLHREV 908
Query: 469 ESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
+ + L+ HLQ +Q+E M+ L ++
Sbjct: 909 AQVRQHMADLEGHLQSAQKERDEMETHLQSLQ 940
Score = 58.2 bits (139), Expect = 3e-08
Identities = 39/159 (24%), Positives = 79/159 (49%), Gaps = 13/159 (8%)
Query: 344 DLQREKNNVEQDLKEKEDTIKQ-------RTSEVQDLQDEVQRENTNLQKLQAQKQQVQE 396
+L R +E+ +E +T+++ ++ +V+ LQ E +QK++ Q Q +
Sbjct: 791 ELDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKEQFLQQKV 850
Query: 397 LLDELDE---QKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE 453
+++ K QL +LK RK+ E + L+ EL + T E EL++ E
Sbjct: 851 MVEAYRRDATSKDQLISELKATRKRLDSE---LKELRQELMQVHGEKRTAEAELSRLHRE 907
Query: 454 LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSM 492
+++++Q A+LE ++S + + + ++ HLQ Q + M
Sbjct: 908 VAQVRQHMADLEGHLQSAQKERDEMETHLQSLQFDKEQM 946
Score = 54.7 bits (130), Expect = 4e-07
Identities = 38/170 (22%), Positives = 78/170 (45%), Gaps = 5/170 (2%)
Query: 334 ELDTLNNE--IVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQK 391
E D L+ E + +Q K VE+DL+ + + + +Q + D L++++
Sbjct: 646 EADMLDQEAAFMQIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTL 705
Query: 392 QQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR 451
Q + L+ L ++ L +QL ++ Q + +L+ ++++ + E A
Sbjct: 706 LQRDQQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASRE 765
Query: 452 EELSRLQQETAELE---ESVESGKAQLEPLQQHLQDSQQEISSMQMKLME 498
+ + LQ E LE ++ +SGK +L+ + L++ +E S KL E
Sbjct: 766 DTICLLQNEKIILEAALQAAKSGKEELDRGARRLEEGTEETSETLEKLRE 815
Score = 51.6 bits (122), Expect = 3e-06
Identities = 59/294 (20%), Positives = 118/294 (40%), Gaps = 29/294 (9%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
+++ L +++ +Q E+ + LK + I S Q Q ++ +LQ +
Sbjct: 538 QQMTALQSQLQQVQLERTTLTSKLKASQAEISSLQSVRQWYQQQLALAQEARVRLQGEMA 597
Query: 393 QVQE-------LLDELDEQKAQLEEQLKEVRKKCAEE----AQLISSLKAELTSQESQIS 441
+Q LL+ L + L +QL E + + +E A + ++A++ QE+
Sbjct: 598 HIQVGQMTQAGLLEHLKLENVSLSQQLTETQHRSMKEKGRIAAQLQGIEADMLDQEAAFM 657
Query: 442 TYEE--------------ELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQ 487
+E E RE L R+ A LE+ +E K L Q L+ QQ
Sbjct: 658 QIQEAKTMVEEDLQRRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQ 717
Query: 488 E-ISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANL--NEHVE 544
E + M+ + + L++ L+ + + L + + S +T L NE +
Sbjct: 718 EHLDLMKQLTLTQEALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKII 777
Query: 545 GQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEE 598
++ L++ +E R + L G + +E + E++ + H ++E
Sbjct: 778 LEAALQAAKSGKEELDRGA-RRLEEGTEETSETLEKLREELAIKSGQVEHLQQE 830
Score = 50.8 bits (120), Expect = 5e-06
Identities = 37/163 (22%), Positives = 80/163 (49%), Gaps = 13/163 (7%)
Query: 344 DLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDE 403
DL + V+ L+ KE+ +Q VQ LQ +++E +K+ + K+QV E
Sbjct: 1148 DLVQLNLQVQAVLQRKEEEDRQMKHLVQALQASLEKEK---EKVNSLKEQVAAAKVEAGH 1204
Query: 404 QKAQLEE---QLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQE 460
+ + +L EV+K+ + L+ L+AE + + + +E+A+ + EL+ + +
Sbjct: 1205 NRRHFKAASLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEARAQ 1264
Query: 461 TAELEESVES-------GKAQLEPLQQHLQDSQQEISSMQMKL 496
L++ ++ G ++E L+ + ++EI S++ +L
Sbjct: 1265 LQLLQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQSLKQQL 1307
Score = 50.4 bits (119), Expect = 7e-06
Identities = 39/172 (22%), Positives = 81/172 (47%), Gaps = 3/172 (1%)
Query: 333 KELDTLNNEIVDLQREKNN---VEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQA 389
+ L+ E LQR ++ +EQ L++ + T+ QR +++ LQ E L Q
Sbjct: 672 RRLEEFEGERERLQRMADSAASLEQQLEQVKLTLLQRDQQLEALQQEHLDLMKQLTLTQE 731
Query: 390 QKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAK 449
Q ++ LD L +L+ +L E++ + A I L+ E E+ + + +
Sbjct: 732 ALQSREQSLDALQTHYDELQARLGELQGEAASREDTICLLQNEKIILEAALQAAKSGKEE 791
Query: 450 AREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
RL++ T E E++E + +L ++ QQE ++++ ++ ++K+
Sbjct: 792 LDRGARRLEEGTEETSETLEKLREELAIKSGQVEHLQQETAALKKQMQKIKE 843
Score = 49.3 bits (116), Expect = 2e-05
Identities = 32/156 (20%), Positives = 68/156 (43%)
Query: 341 EIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDE 400
E++ + +EK +E L+ Q E +LQ ++ +T LQ Q+ D
Sbjct: 406 EMLQVLKEKMRLEGQLEALSLEASQALKEKAELQAQLAALSTKLQAQVECSHSSQQRQDS 465
Query: 401 LDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQE 460
L + L++ ++ + + ++ + A L S + + EE+ + ++ +Q+
Sbjct: 466 LSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEEQYQRLMAKVEDMQRS 525
Query: 461 TAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKL 496
+ +V + Q+ LQ LQ Q E +++ KL
Sbjct: 526 MLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKL 561
Score = 49.3 bits (116), Expect = 2e-05
Identities = 44/170 (25%), Positives = 83/170 (48%), Gaps = 22/170 (12%)
Query: 348 EKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQ 407
E + V+++L+ KE +++ +E DLQ + + + + QA+ L E Q
Sbjct: 1215 ELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAE-------LAEARAQLQL 1267
Query: 408 LEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQ----ETAE 463
L++QL E K Q + +LK E+ +E +I + +++L +Q E
Sbjct: 1268 LQKQLDEQLSKQPVGNQEMENLKWEVDQKEREIQS-------LKQQLDLTEQQGRKELEG 1320
Query: 464 LEESVESGKAQLEPLQQHLQDSQQEISSMQMKLME----MKDLENHNSQL 509
L++ +++ K++LE Q+ L +Q++ +Q K+ E MK L N QL
Sbjct: 1321 LQQLLQNVKSELEMAQEDLSMTQKDKFMLQAKVSELKNNMKTLLQQNQQL 1370
Score = 47.8 bits (112), Expect = 5e-05
Identities = 38/170 (22%), Positives = 82/170 (48%), Gaps = 8/170 (4%)
Query: 332 IKELDTLNNEI-VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQ 390
IK L+ N ++ ++L+ EK + L + +++ S L+ + + +L +L Q
Sbjct: 1100 IKRLEESNKKLALELEHEKGKLT-GLGQSNAALREHNSI---LETALAKREADLVQLNLQ 1155
Query: 391 KQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKA 450
VQ +L +E+ Q++ ++ ++ +E + ++SLK ++ + + + A
Sbjct: 1156 ---VQAVLQRKEEEDRQMKHLVQALQASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFKAA 1212
Query: 451 REELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
ELS +++E E V+ +A+ + LQ QEI+ Q +L E +
Sbjct: 1213 SLELSEVKKELQAKEHLVQKLQAEADDLQIREGKHSQEIAQFQAELAEAR 1262
Score = 47.0 bits (110), Expect = 8e-05
Identities = 58/255 (22%), Positives = 110/255 (43%), Gaps = 17/255 (6%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
++L+ L E +DL ++ ++ L+ +E ++ + +LQ L +LQ +
Sbjct: 710 QQLEALQQEHLDLMKQLTLTQEALQSREQSLDALQTHYDELQ-------ARLGELQGEAA 762
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQ-ISTYEEELAKAR 451
++ + L +K LE L + K EE + E T + S+ + EELA
Sbjct: 763 SREDTICLLQNEKIILEAAL-QAAKSGKEELDRGARRLEEGTEETSETLEKLREELAIKS 821
Query: 452 EELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENH-NSQLN 510
++ LQQETA L++ ++ K Q + ++ +++ +S + E+K +S+L
Sbjct: 822 GQVEHLQQETAALKKQMQKIKEQFLQQKVMVEAYRRDATSKDQLISELKATRKRLDSELK 881
Query: 511 WCSSPHSILVNG--ATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLP 568
+ V+G T LS E A + +H+ ++LE + R E
Sbjct: 882 ELRQ-ELMQVHGEKRTAEAELSRLHREVAQVRQHM---ADLEGH-LQSAQKERDEMETHL 936
Query: 569 SGVTDENEVTTAVTE 583
+ + E AVTE
Sbjct: 937 QSLQFDKEQMVAVTE 951
Score = 42.0 bits (97), Expect = 0.003
Identities = 47/258 (18%), Positives = 100/258 (38%), Gaps = 24/258 (9%)
Query: 289 ISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQRE 348
I K + D P+++ + IP + + F +IK D L + Q +
Sbjct: 331 ILSKTVGTQDTPYMVNGQEIP-------------ADTLGQFPSIK--DVLQAAAAEHQDQ 375
Query: 349 KNNVEQDLKEKEDTIKQRTS---EVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQK 405
V +++ + D+I S + Q+E+ + +L+ Q + + + ++K
Sbjct: 376 GQEVNGEVRSRRDSICSSVSLESSAAETQEEMLQVLKEKMRLEGQLEALSLEASQALKEK 435
Query: 406 AQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELE 465
A+L+ QL + K + + S + S S++ T ++ ++ LQ
Sbjct: 436 AELQAQLAALSTKLQAQVECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKN 495
Query: 466 ESVESGKAQLEPLQQHLQDSQQEISSMQMKLME----MKDLENHNSQLNWCSSPHSILVN 521
S+ S L+ ++ Q ++ MQ ++ + DL + L S + +
Sbjct: 496 ASLASSNNDLQVAEEQYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQ--SQLQQVQLE 553
Query: 522 GATDYCSLSTSSSETANL 539
T L S +E ++L
Sbjct: 554 RTTLTSKLKASQAEISSL 571
Score = 41.2 bits (95), Expect = 0.004
Identities = 32/150 (21%), Positives = 77/150 (51%), Gaps = 11/150 (7%)
Query: 338 LNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQ----DEVQRENTNLQKLQAQKQQ 393
L E DLQ + Q++ + + + + +++Q LQ +++ ++ Q+++ K +
Sbjct: 1233 LQAEADDLQIREGKHSQEIAQFQAELAEARAQLQLLQKQLDEQLSKQPVGNQEMENLKWE 1292
Query: 394 VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE 453
V + E+ K QL+ ++ RK+ QL+ ++K+EL +E+L+ +++
Sbjct: 1293 VDQKEREIQSLKQQLDLTEQQGRKELEGLQQLLQNVKSEL-------EMAQEDLSMTQKD 1345
Query: 454 LSRLQQETAELEESVESGKAQLEPLQQHLQ 483
LQ + +EL+ ++++ Q + L+ L+
Sbjct: 1346 KFMLQAKVSELKNNMKTLLQQNQQLKLDLR 1375
Score = 40.8 bits (94), Expect = 0.006
Identities = 33/167 (19%), Positives = 73/167 (43%), Gaps = 11/167 (6%)
Query: 343 VDLQREKNNVEQDLKEKEDTIKQRTSEVQ----DLQDEVQRENTNLQKLQAQKQQVQELL 398
V+ + L + DT+KQ +++ DLQ+ ++ +N +L Q +E
Sbjct: 453 VECSHSSQQRQDSLSSEVDTLKQSCWDLERAMTDLQNMLEAKNASLASSNNDLQVAEE-- 510
Query: 399 DELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQ 458
Q +L +++++++ + + L+ ++T+ +SQ+ + E +L Q
Sbjct: 511 -----QYQRLMAKVEDMQRSMLSKDNTVHDLRQQMTALQSQLQQVQLERTTLTSKLKASQ 565
Query: 459 QETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENH 505
E + L+ + + QL Q+ Q E++ +Q+ M L H
Sbjct: 566 AEISSLQSVRQWYQQQLALAQEARVRLQGEMAHIQVGQMTQAGLLEH 612
Score = 36.6 bits (83), Expect = 0.11
Identities = 53/273 (19%), Positives = 117/273 (42%), Gaps = 28/273 (10%)
Query: 336 DTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQK----LQAQK 391
+ L +I +LQ+E + K+K +++ S++ Q E++ ++ + L +
Sbjct: 954 EALKKQIEELQQEARKAITEQKQK---MRRLGSDLTSAQKEMKTKHKAYENAVGILSRRL 1010
Query: 392 QQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEEL---- 447
Q+ + D + QL Q A + I +L+AEL + + E+EL
Sbjct: 1011 QEALAAKEAADAELGQLRAQGGSSDSSLALHER-IQALEAELQAVSHSKTLLEKELQEVI 1069
Query: 448 AKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNS 507
A +EL +++ ELE+ ++ + + +++ L++S ++++ ++L K
Sbjct: 1070 ALTSQELEESREKVLELEDELQESRGFRKKIKR-LEESNKKLA---LELEHEKGKLTGLG 1125
Query: 508 QLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELL 567
Q N H+ ++ A L+ ++ LN V+ + E ++ + + L
Sbjct: 1126 QSNAALREHNSILETA-----LAKREADLVQLNLQVQAVLQRKEE---EDRQMKHLVQAL 1177
Query: 568 PSGVTDENEVTTAVTEKVCSEL----DNNRHSK 596
+ + E E ++ E+V + N RH K
Sbjct: 1178 QASLEKEKEKVNSLKEQVAAAKVEAGHNRRHFK 1210
>gi|36031016 CTCL tumor antigen L14-2 [Homo sapiens]
Length = 898
Score = 66.2 bits (160), Expect = 1e-10
Identities = 41/182 (22%), Positives = 94/182 (51%), Gaps = 14/182 (7%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQ 393
EL TL ++ L+ E+ E +L + ++ I ++ +E+Q+L D+V+ + ++LQ KQ+
Sbjct: 497 ELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQE 556
Query: 394 VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLI----------SSLKAELTSQESQISTY 443
++ L +E++ + + + K++ E++L+ + L++E S +SQ
Sbjct: 557 IENLKEEVESLNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKV 616
Query: 444 EEELAKAREELSRLQQETAELEESV----ESGKAQLEPLQQHLQDSQQEISSMQMKLMEM 499
++ + + +++Q LE + E K +++ LQ L Q E+ ++ ++ E+
Sbjct: 617 SCSESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEEL 676
Query: 500 KD 501
KD
Sbjct: 677 KD 678
Score = 57.8 bits (138), Expect = 4e-08
Identities = 41/182 (22%), Positives = 90/182 (49%), Gaps = 19/182 (10%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQ- 390
IKE VD+ EK+N+ ++LK++ +T KQ + ++ L+ ++ N ++ + Q
Sbjct: 213 IKENKKHQELFVDICSEKDNLREELKKRTETEKQHMNTIKQLESRIEELNKEVKASRDQL 272
Query: 391 -------KQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLIS---------SLKAELT 434
K VQ+L E+ ++ Q ++ +E R++ +EA ++ L+ E
Sbjct: 273 IAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQE--KEAMVMKYVRGEKESLDLRKEKE 330
Query: 435 SQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQM 494
+ E ++ +EL K ++ +L QE L + E+ + + L + + +++I+S +
Sbjct: 331 TLEKKLRDANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVI 390
Query: 495 KL 496
K+
Sbjct: 391 KV 392
Score = 57.8 bits (138), Expect = 4e-08
Identities = 57/250 (22%), Positives = 124/250 (49%), Gaps = 28/250 (11%)
Query: 339 NNEI-VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQEL 397
+NE+ L+ K +E+ ++EK D ++ +++++L+D + + +L+ + +V+ L
Sbjct: 449 SNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCL 508
Query: 398 LDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRL 457
DE + + E++L + + ++I+ KAE+ + ++ T ++ +E+L R
Sbjct: 509 EDE----RLRTEDELSKYK-------EIINRQKAEIQNLLDKVKTADQ----LQEQLQRG 553
Query: 458 QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHS 517
+QE L+E VES + + LQ+ ++ S++ S + L+ + L + N+QL S +S
Sbjct: 554 KQEIENLKEEVESLNSLINDLQKDIEGSRKRESEL---LLFTERLTSKNAQLQ--SESNS 608
Query: 518 ILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGV----TD 573
+ CS S S+ + + NLES + +E + + L + + T+
Sbjct: 609 LQSQFDKVSCSESQLQSQCEQMK---QTNINLESRLLKEEELRKEEVQTLQAELACRQTE 665
Query: 574 ENEVTTAVTE 583
++T V E
Sbjct: 666 VKALSTQVEE 675
Score = 56.2 bits (134), Expect = 1e-07
Identities = 41/178 (23%), Positives = 87/178 (48%), Gaps = 13/178 (7%)
Query: 331 AIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQ----K 386
A KEL+ N+I L +EK + Q + KE + E+ L++++ ++ K
Sbjct: 339 ANKELEKNTNKIKQLSQEKGRLHQLYETKEGETTRLIREIDKLKEDINSHVIKVKWAQNK 398
Query: 387 LQAQKQQVQELLDELDE---QKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTY 443
L+A+ +E D+L E + Q +E+ ++RK C + +K S+E + +
Sbjct: 399 LKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQD------MIKTYQESEEIKSNEL 452
Query: 444 EEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+ +L + EL + QE ++ E + +LE L++ ++ E+ +++ K+ ++D
Sbjct: 453 DAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEGMDELRTLRTKVKCLED 510
Score = 56.2 bits (134), Expect = 1e-07
Identities = 46/199 (23%), Positives = 101/199 (50%), Gaps = 27/199 (13%)
Query: 332 IKELDTL----NNEIVDLQREKNNVEQDL---KEKEDTIKQRTSEVQDLQDEVQRENTNL 384
I+E+D L N+ ++ ++ +N ++ ++ KE +D +K+ T+++ ++E + N
Sbjct: 375 IREIDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNC 434
Query: 385 QKLQAQKQQVQEL----LD--------ELDEQKAQLEEQLKEVRKKCAEEAQLISSLKA- 431
Q + Q+ +E+ LD EL++Q + +QL+ K E L + K
Sbjct: 435 QDMIKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLKRTFKEG 494
Query: 432 --ELTSQESQISTYEEELAKAREELSR----LQQETAELEESVESGKAQLEPLQQHLQDS 485
EL + +++ E+E + +ELS+ + ++ AE++ ++ K + LQ+ LQ
Sbjct: 495 MDELRTLRTKVKCLEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKT-ADQLQEQLQRG 553
Query: 486 QQEISSMQMKLMEMKDLEN 504
+QEI +++ ++ + L N
Sbjct: 554 KQEIENLKEEVESLNSLIN 572
Score = 51.2 bits (121), Expect = 4e-06
Identities = 34/171 (19%), Positives = 87/171 (50%), Gaps = 11/171 (6%)
Query: 341 EIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDE 400
E +DL++EK +E+ L++ +++ T++++ L E R + Q + ++ + L+ E
Sbjct: 321 ESLDLRKEKETLEKKLRDANKELEKNTNKIKQLSQEKGRLH---QLYETKEGETTRLIRE 377
Query: 401 LDEQKAQLEE---QLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR---EEL 454
+D+ K + ++K + K E K +L ++++ +EE + R +++
Sbjct: 378 IDKLKEDINSHVIKVKWAQNKLKAEMDSHKETKDKLKETTTKLTQAKEEADQIRKNCQDM 437
Query: 455 SRLQQETAELEESVESGKAQLE--PLQQHLQDSQQEISSMQMKLMEMKDLE 503
+ QE+ E++ + K ++ L++ +Q+ ++ K+ E++DL+
Sbjct: 438 IKTYQESEEIKSNELDAKLRVTKGELEKQMQEKSDQLEMHHAKIKELEDLK 488
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/206 (20%), Positives = 100/206 (48%), Gaps = 19/206 (9%)
Query: 303 LTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDT 362
L E + D S K II + + ++ T + LQR K +E +LKE+ ++
Sbjct: 508 LEDERLRTEDELSKYKEIINRQKAEIQNLLDKVKTADQLQEQLQRGKQEIE-NLKEEVES 566
Query: 363 IKQRTSEVQ-DLQDEVQRENTNL----------QKLQAQKQQVQELLDELDEQKAQLEEQ 411
+ +++Q D++ +RE+ L +LQ++ +Q D++ ++QL+ Q
Sbjct: 567 LNSLINDLQKDIEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSCSESQLQSQ 626
Query: 412 LKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESG 471
+++++ L S L E ++ ++ T + ELA + E+ L + EL++ + +
Sbjct: 627 CEQMKQ---TNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKDELVTQ 683
Query: 472 K----AQLEPLQQHLQDSQQEISSMQ 493
+ + ++ L + LQ +++++ ++
Sbjct: 684 RRKHASSIKDLTKQLQQARRKLDQVE 709
Score = 40.8 bits (94), Expect = 0.006
Identities = 40/174 (22%), Positives = 86/174 (49%), Gaps = 12/174 (6%)
Query: 324 SPVADFSAIKEL-DTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENT 382
S + SA ++L + + +E++ + ++ V + + E + VQD +Q+E+
Sbjct: 151 SKIKSVSASEDLLEEIESELLSTEFAEHRVPNGMNKGEHALVLFEKCVQDKY--LQQEHI 208
Query: 383 NLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQIST 442
++KL + ++ QEL ++ +K L E+LK K+ E Q ++++K ES+I
Sbjct: 209 -IKKLIKENKKHQELFVDICSEKDNLREELK---KRTETEKQHMNTIK----QLESRIEE 260
Query: 443 YEEELAKAREELSRLQQETAELEESVESGKAQ-LEPLQQHLQDSQQEISSMQMK 495
+E+ +R++L + + AQ +E + ++++QE +M MK
Sbjct: 261 LNKEVKASRDQLIAQDVTAKNAVQQLHKEMAQRMEQANKKCEEARQEKEAMVMK 314
Score = 40.8 bits (94), Expect = 0.006
Identities = 37/160 (23%), Positives = 75/160 (46%), Gaps = 28/160 (17%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTI---KQRTSEVQDLQDEVQRENTNLQKLQA 389
+E+++LN+ I DLQ++ +E K + + + ++ TS+ LQ E + K+
Sbjct: 562 EEVESLNSLINDLQKD---IEGSRKRESELLLFTERLTSKNAQLQSESNSLQSQFDKVSC 618
Query: 390 QKQQVQELLDELDEQKAQLEEQL---KEVRKKCAEEAQL---------------ISSLKA 431
+ Q+Q +++ + LE +L +E+RK+ + Q + LK
Sbjct: 619 SESQLQSQCEQMKQTNINLESRLLKEEELRKEEVQTLQAELACRQTEVKALSTQVEELKD 678
Query: 432 ELTSQE----SQISTYEEELAKAREELSRLQQETAELEES 467
EL +Q S I ++L +AR +L +++ + + E S
Sbjct: 679 ELVTQRRKHASSIKDLTKQLQQARRKLDQVESGSYDKEVS 718
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 66.2 bits (160), Expect = 1e-10
Identities = 38/163 (23%), Positives = 86/163 (52%), Gaps = 7/163 (4%)
Query: 345 LQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQ 404
L +EK ++++ E + Q + ++ + E +NL+KL+ +++Q+ LD+L+
Sbjct: 1785 LSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQQELDQLNRD 1844
Query: 405 KAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKARE-------ELSRL 457
K L + ++++ E+ + ++SL+ EL + + ++ +++L + E +RL
Sbjct: 1845 KLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQDVLLSEQTRL 1904
Query: 458 QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
Q++ +E E + + E QQ LQ Q EI ++KL++ +
Sbjct: 1905 QKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQE 1947
Score = 62.8 bits (151), Expect = 1e-09
Identities = 48/266 (18%), Positives = 124/266 (46%), Gaps = 27/266 (10%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQK 391
+ EL+ +++ + E N++Q +Q+ E++ + ++R+ ++++ A+
Sbjct: 1723 VSELEKTQVAVLEEKLELENLQQ-------ISQQQKGEIEWQKQLLERDKREIERMTAES 1775
Query: 392 QQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAR 451
+ +Q ++ L ++K L+E+ KK A+ +++++ + ++S + E + K +
Sbjct: 1776 RALQSCVECLSKEKEDLQEKCDIWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRKLQ 1835
Query: 452 EELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNW 511
+EL +L ++ L + + +QQ LQ+ ++ ++S+Q +L ++D N Q
Sbjct: 1836 QELDQLNRDKLSLHNDISA-------MQQQLQEKREAVNSLQEELANVQDHLNLAKQDLL 1888
Query: 512 CSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGV 571
++ H ++ SE L + + +N + +E + ++L + +
Sbjct: 1889 HTTKHQDVL------------LSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEI 1936
Query: 572 TDENEVTTAVTEKVCSELDNNRHSKE 597
+EN++ E + L R S+E
Sbjct: 1937 -EENKLKLVQQEMMFQRLQKERESEE 1961
Score = 61.2 bits (147), Expect = 4e-09
Identities = 46/220 (20%), Positives = 104/220 (47%), Gaps = 14/220 (6%)
Query: 345 LQREKNNVEQDLKEKEDTIKQRTSEVQDLQ---DEVQRENTNLQKLQAQKQQVQELLDEL 401
L++E ++E +++++ I + E++DLQ D + ++ ++AQK ++ LD +
Sbjct: 508 LRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSKDPKHSHMKAQKSGKEQQLDIM 567
Query: 402 DEQKAQLEEQLKEVRKKCAEEAQLISSLKAELT-----SQESQISTYEEELAKAREELSR 456
++Q QLE +L E+ + A+E + I L+ +LT + E+ E ++ +E L
Sbjct: 568 NKQYQQLESRLDEILSRIAKETEEIKDLEEQLTEGQIAANEALKKDLEGVISGLQEYLGT 627
Query: 457 LQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPH 516
++ + + + + + E L Q L + +QE +++ M+ +++ ++L
Sbjct: 628 IKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQLEIVAMDAENMRKELAEL------E 681
Query: 517 SILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQ 556
S L SL + + + +E + NL +Q
Sbjct: 682 SALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQ 721
Score = 60.1 bits (144), Expect = 9e-09
Identities = 63/280 (22%), Positives = 120/280 (42%), Gaps = 38/280 (13%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
KE++ L++ I DL +EK ++E +++E T+++R + + V+ T L+ ++ +
Sbjct: 1354 KEMEELHHNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESLMTELE-IEKSLK 1412
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKARE 452
++++DE++ +E+ L + R + E +L++ ++EL+ + + E+ A+
Sbjct: 1413 HHEDIVDEIE----CIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAKR 1468
Query: 453 ELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHN-SQLNW 511
L + + + ELE + L Q L+ Q + KDLE H Q
Sbjct: 1469 SLLQTESDAEELERRAQETAVNLVKADQQLRSLQ----------ADAKDLEQHKIKQEEI 1518
Query: 512 CSSPHSILVNGATDYCSLSTSSS-------------ETANLNEHVEGQSNLESEPIHQES 558
+ I+ +D+ LS E A NE Q ESE + Q
Sbjct: 1519 LKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEVLLQAK 1578
Query: 559 PARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEE 598
R+ E L S VT + + + ++ H KEE
Sbjct: 1579 --RAELEKLKSQVTSQQQEMAVLDRQL-------GHKKEE 1609
Score = 60.1 bits (144), Expect = 9e-09
Identities = 52/217 (23%), Positives = 101/217 (46%), Gaps = 49/217 (22%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQ-------------- 378
+ELD LN + + L + + ++Q L+EK + + E+ ++QD +
Sbjct: 1836 QELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAKQDLLHTTKHQD 1895
Query: 379 ---RENTNLQK---------------LQAQKQQVQELLDELDEQKAQLEEQ----LKEVR 416
E T LQK + ++QQ+Q L +E++E K +L +Q + +
Sbjct: 1896 VLLSEQTRLQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLVQQEMMFQRLQK 1955
Query: 417 KKCAEEAQLISS----------LKAELTSQESQISTYEEELAKAREELSRLQQE---TAE 463
++ +EE++L +S L+ ELT Q+S++ ++ A E + LQ+E
Sbjct: 1956 ERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCES 2015
Query: 464 LEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
LE+++ K QL +Q L + E+ ++Q + M+
Sbjct: 2016 LEKTLSQTKRQLSEREQQLVEKSGELLALQKEADSMR 2052
Score = 57.4 bits (137), Expect = 6e-08
Identities = 42/179 (23%), Positives = 85/179 (47%), Gaps = 10/179 (5%)
Query: 330 SAIKELDTL----NNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQ 385
S ++E D L +E+ + + N + + + ++ Q S+ ++L+ Q NL
Sbjct: 1433 SELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLV 1492
Query: 386 KLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCA---EEAQLISSLKAELTSQESQIST 442
K Q + +Q +L++ K + EE LKE+ K A + Q +S K +LT ++
Sbjct: 1493 KADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLT---EELQK 1549
Query: 443 YEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
++++ A Q E E +++ +A+LE L+ + QQE++ + +L K+
Sbjct: 1550 LQKDIEMAERNEDHHLQVLKESEVLLQAKRAELEKLKSQVTSQQQEMAVLDRQLGHKKE 1608
Score = 52.8 bits (125), Expect = 1e-06
Identities = 42/191 (21%), Positives = 88/191 (46%), Gaps = 23/191 (12%)
Query: 338 LNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQ--RENTNLQKLQAQKQQVQ 395
L E+ L R+K ++ D+ + ++++ V LQ+E+ +++ NL K Q
Sbjct: 1834 LQQELDQLNRDKLSLHNDISAMQQQLQEKREAVNSLQEELANVQDHLNLAK--------Q 1885
Query: 396 ELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREEL- 454
+LL Q L EQ + ++K +E A + E +++ Q+ + E+ + + +L
Sbjct: 1886 DLLHTTKHQDVLLSEQTR-LQKDISEWANRFEDCQKEEETKQQQLQVLQNEIEENKLKLV 1944
Query: 455 ------SRLQQETAELEESVESGKAQLE----PLQQHLQDSQQEISSMQMKLMEMKD-LE 503
RLQ+E E +E+ K L+ L++ L D + ++ + K++ ++ +
Sbjct: 1945 QQEMMFQRLQKERESEESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVR 2004
Query: 504 NHNSQLNWCSS 514
+ WC S
Sbjct: 2005 TLQEEERWCES 2015
Score = 52.4 bits (124), Expect = 2e-06
Identities = 43/195 (22%), Positives = 89/195 (45%), Gaps = 18/195 (9%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEV------QRENTNLQKL 387
E L V L+ +++ +E++L +++ + Q S+V ++ V +R +L+K
Sbjct: 1960 EESKLETSKVTLKEQQHQLEKELTDQKSKLDQVLSKVLAAEERVRTLQEEERWCESLEKT 2019
Query: 388 QAQ-KQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEE 446
+Q K+Q+ E +L E+ +L KE A+ + L + E E Q+++ +E
Sbjct: 2020 LSQTKRQLSEREQQLVEKSGELLALQKEADSMRADFSLLRNQFLTERKKAEKQVASLKEA 2079
Query: 447 LAKAREELSR-----------LQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMK 495
L R +L + +Q+E A +E + + L + L Q E + ++ +
Sbjct: 2080 LKIQRSQLEKNLLEQKQENSCIQKEMATIELVAQDNHERARRLMKELNQMQYEYTELKKQ 2139
Query: 496 LMEMKDLENHNSQLN 510
+ KDLE +++
Sbjct: 2140 MANQKDLERRQMEIS 2154
Score = 51.2 bits (121), Expect = 4e-06
Identities = 43/172 (25%), Positives = 83/172 (48%), Gaps = 17/172 (9%)
Query: 331 AIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQ 390
A ++L +L + DL++ K E+ LKE + + S+ Q L + ++ LQKLQ
Sbjct: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEKLTEELQKLQKD 1553
Query: 391 KQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKA 450
+ + + E+ +V K E L+ + +AEL +SQ+++ ++E+A
Sbjct: 1554 IEMAE-----------RNEDHHLQVLK---ESEVLLQAKRAELEKLKSQVTSQQQEMAVL 1599
Query: 451 REELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDL 502
+L ++E L+ S+ KA LQ+ L+ + E++ + E+K L
Sbjct: 1600 DRQLGHKKEELHLLQGSMVQAKAD---LQEALRLGETEVTEKCNHIREVKSL 1648
Score = 49.7 bits (117), Expect = 1e-05
Identities = 46/183 (25%), Positives = 93/183 (50%), Gaps = 19/183 (10%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQ-RTSEVQ---DLQDEVQRENTNLQKLQA 389
EL+ L +++ Q+E +++ L K++ + + S VQ DLQ+ ++ T + +
Sbjct: 1581 ELEKLKSQVTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCN 1640
Query: 390 QKQQVQELLDELDEQKAQLEEQLKE-------VRKKCAEEAQLISSLKAELTSQESQIST 442
++V+ LL+EL QK +L Q+ E ++++ +E + + + +++ ++++
Sbjct: 1641 HIREVKSLLEELSFQKGELNVQISERKTQLTLIKQEIEKEEENLQVVLRQMSKHKTELKN 1700
Query: 443 YEEELAKAREELSRLQ----QETAELEE---SVESGKAQLEPLQQHLQDSQQEISSMQMK 495
+ L EL L+ Q +ELE+ +V K +LE LQQ Q + EI Q +
Sbjct: 1701 ILDMLQLENHELQGLKLQHDQRVSELEKTQVAVLEEKLELENLQQISQQQKGEI-EWQKQ 1759
Query: 496 LME 498
L+E
Sbjct: 1760 LLE 1762
Score = 43.9 bits (102), Expect = 7e-04
Identities = 48/229 (20%), Positives = 102/229 (44%), Gaps = 29/229 (12%)
Query: 271 TKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFS 330
T+ C K + + LAF+ I K P PS+ A + K S +
Sbjct: 343 TRACQKQYELEQELAFYKIDAKF----------EPLNYYPSEYAEIDKAPDESPYIGKSR 392
Query: 331 AIKELDTLNNEIVD----LQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQK 386
+ + + I+D +Q +K ++ L+ ++ T L+D+ + K
Sbjct: 393 YKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEK-------K 445
Query: 387 LQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEE 446
+ A + ++ EL DE+++ + Q+ +E + QL +++ + S+ + Y++
Sbjct: 446 ISAAQTRLSELHDEIEKAEQQILRATEEFK-------QLEEAIQLKKISEAGKDLLYKQ- 497
Query: 447 LAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMK 495
L+ + +++L+QE +LE +E K ++ Q+ ++D Q I S+ K
Sbjct: 498 LSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK 546
Score = 43.9 bits (102), Expect = 7e-04
Identities = 40/172 (23%), Positives = 84/172 (48%), Gaps = 15/172 (8%)
Query: 335 LDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQV 394
L T+ + Q E L+++++T+ QR +EV+ +E L+ + + +
Sbjct: 625 LGTIKGQATQAQNECRK----LRDEKETLLQRLTEVE-------QERDQLEIVAMDAENM 673
Query: 395 QELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREEL 454
++ L EL+ + E +++ + + + L+A L ++++ + +EEL K L
Sbjct: 674 RKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV-TRL 732
Query: 455 SRLQQET--AELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLEN 504
++L+Q AELE+ ++ K L Q ++ +QE S + KL ++D N
Sbjct: 733 TQLEQSALQAELEKERQALKNALGK-AQFSEEKEQENSELHAKLKHLQDDNN 783
Score = 43.5 bits (101), Expect = 9e-04
Identities = 46/196 (23%), Positives = 87/196 (44%), Gaps = 27/196 (13%)
Query: 318 KNIIGSSPVADFSAIKELDT--LNNEIVDLQREKNNVEQDLKEKEDTIKQ------RTSE 369
KN +G A FS KE + L+ ++ LQ + N ++Q LK+ ++ + R E
Sbjct: 752 KNALGK---AQFSEEKEQENSELHAKLKHLQDDNNLLKQQLKDFQNHLNHVVDGLVRPEE 808
Query: 370 VQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSL 429
V DE++R+ KL + + D L + A L++Q E+ ++
Sbjct: 809 VAARVDELRRK----LKLGTGEMNIHSPSDVLGKSLADLQKQFSEI----------LARS 854
Query: 430 KAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQ--HLQDSQQ 487
K E + + +EE+A +E+L+ Q+E + E + + Q +Q +
Sbjct: 855 KWERDEAQVRERKLQEEMALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMEN 914
Query: 488 EISSMQMKLMEMKDLE 503
EI +Q L M++++
Sbjct: 915 EIHYLQENLKSMEEIQ 930
Score = 43.1 bits (100), Expect = 0.001
Identities = 36/188 (19%), Positives = 89/188 (47%), Gaps = 30/188 (15%)
Query: 344 DLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDE 403
+++R + ++E+ + E E+ ++T +++++++ + + ++ QKQ +EL +L+
Sbjct: 271 EVERLERDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNT 330
Query: 404 QKAQLEEQLKEVRKKCAEEAQLISSLK-AELTSQESQISTYEEELA---KAREE------ 453
+ L+++ E+ + C ++ +L L ++ ++ ++ Y E A KA +E
Sbjct: 331 KNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYYPSEYAEIDKAPDESPYIGK 390
Query: 454 -----------------LSRLQQETAELEESVESGKAQLE---PLQQHLQDSQQEISSMQ 493
+Q + E +E + + L PL L+D +++IS+ Q
Sbjct: 391 SRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQ 450
Query: 494 MKLMEMKD 501
+L E+ D
Sbjct: 451 TRLSELHD 458
Score = 43.1 bits (100), Expect = 0.001
Identities = 34/150 (22%), Positives = 70/150 (46%), Gaps = 15/150 (10%)
Query: 364 KQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKK----C 419
+Q + +Q +++E+ NL+ ++ + L E DE+K ++ QL+E+ KK
Sbjct: 903 RQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLED 962
Query: 420 AEEAQLISSLKAELTSQESQISTYEE----ELAKAREELS-------RLQQETAELEESV 468
A+ + + L EL + ++T ++ EL A+++L ++ QE AE +
Sbjct: 963 AKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQEA 1022
Query: 469 ESGKAQLEPLQQHLQDSQQEISSMQMKLME 498
E + + L ++ EI +Q L +
Sbjct: 1023 ERFSRKAAQAARDLTRAEAEIELLQNLLRQ 1052
Score = 42.7 bits (99), Expect = 0.001
Identities = 34/156 (21%), Positives = 73/156 (46%), Gaps = 22/156 (14%)
Query: 355 DLKEKEDTIKQRTSEVQDLQDEVQR-------ENTNLQKLQAQKQQVQELLDELD----- 402
D ++ E I+Q +E+ LQ+ ++ + LQ+ +K+++ L EL+
Sbjct: 901 DKRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKL 960
Query: 403 ------EQKAQLEEQLKEVRKKCAEEAQL----ISSLKAELTSQESQISTYEEELAKARE 452
EQ L+++LK+++K A +L ++ K +L S + +E A+ +
Sbjct: 961 EDAKSQEQVFGLDKELKKLKKAVATSDKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020
Query: 453 ELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQE 488
E R ++ A+ + +A++E LQ L+ ++
Sbjct: 1021 EAERFSRKAAQAARDLTRAEAEIELLQNLLRQKGEQ 1056
Score = 36.6 bits (83), Expect = 0.11
Identities = 30/161 (18%), Positives = 71/161 (44%), Gaps = 23/161 (14%)
Query: 363 IKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELD-------EQKAQLEEQLKEV 415
++ S ++D+ ++ + + ++A K+Q ++ ++EL ++K LE +++E+
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEELHHNIDDLLQEKKSLECEVEEL 1380
Query: 416 RKKCAEEAQL-------ISSLKAELTSQES---------QISTYEEELAKAREELSRLQQ 459
+ + Q + SL EL ++S +I E+ L K R EL +
Sbjct: 1381 HRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRSELREADR 1440
Query: 460 ETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
AE E + K + + + D+++ + + E++
Sbjct: 1441 LLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELE 1481
Score = 33.9 bits (76), Expect = 0.70
Identities = 32/112 (28%), Positives = 55/112 (49%), Gaps = 15/112 (13%)
Query: 375 DEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLK---EVRKKCAEEAQLISSLKA 431
+EV+R +L+K + +EL ++ + E++K ++ K EEA L
Sbjct: 270 EEVERLERDLEKKMIE-------TEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCE 322
Query: 432 ELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGK--AQLEPLQQH 481
EL +S ++T E L + EL+R Q+ ELE+ + K A+ EPL +
Sbjct: 323 EL---KSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFEPLNYY 371
>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
Length = 1976
Score = 65.5 bits (158), Expect = 2e-10
Identities = 35/174 (20%), Positives = 92/174 (52%), Gaps = 8/174 (4%)
Query: 336 DTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQ 395
D + + +L++ K +EQ ++E +++ E+Q +D R N+Q ++AQ ++
Sbjct: 1521 DDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDL 1580
Query: 396 ELLDELDEQKA--------QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEEL 447
+ DE +E+K +LE +L++ RK+ A ++ +L E+QI +
Sbjct: 1581 QTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKAR 1640
Query: 448 AKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+ ++L +LQ + + + +E +A + + ++S++++ S++ +++++++
Sbjct: 1641 DEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQE 1694
Score = 62.8 bits (151), Expect = 1e-09
Identities = 64/298 (21%), Positives = 125/298 (41%), Gaps = 40/298 (13%)
Query: 290 SQKLIKGIDPPHVLTPEMIPPSDRASLQK--------NIIGSSPVADFSAIKELDTLNNE 341
S+K +K ++ + E + S+RA + I +S + + E L
Sbjct: 1678 SEKKLKSLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEAR 1737
Query: 342 IVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQ-------- 393
I L+ E + +++ D ++ T +V L E+ E + QK +QQ
Sbjct: 1738 IAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKEL 1797
Query: 394 ---VQEL-----------LDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQ 439
+QEL + L+ + QLEEQL++ K+ A +L+ + +L Q
Sbjct: 1798 KAKLQELEGAVKSKFKATISALEAKIGQLEEQLEQEAKERAAANKLVRRTEKKLKEIFMQ 1857
Query: 440 I-------STYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSM 492
+ Y+E++ KA + +L+++ E EE A LQ+ L D+ + +
Sbjct: 1858 VEDERRHADQYKEQMEKANARMKQLKRQLEEAEEEATRANASRRKLQRELDDATEANEGL 1917
Query: 493 QMKLMEMKDLENHNSQLNWCSS---PHSILVNGATDYCSLSTSSSETANLNEHVEGQS 547
++ +K+ +++ SS + + GA+ S + S+T+++NE QS
Sbjct: 1918 SREVSTLKNRLRRGGPISFSSSRSGRRQLHLEGASLELSDDDTESKTSDVNETQPPQS 1975
Score = 62.4 bits (150), Expect = 2e-09
Identities = 62/301 (20%), Positives = 136/301 (45%), Gaps = 33/301 (10%)
Query: 344 DLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDE 403
+L + +N E + + E+ +K+ Q+L+ ++ + LQ Q ++Q +DEL
Sbjct: 1024 NLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKL 1083
Query: 404 QKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463
Q A+ EE+L+ + +E ++ + ++QI+ +E+ + ++ +++ +
Sbjct: 1084 QLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRD 1143
Query: 464 LEESVESGKAQLE------PLQQHLQDS-QQEISSMQMKLMEMKDLENHNSQLNWCSSPH 516
L E +E+ K +LE QQ L+ +QE++ ++ L E + +NH +Q+ H
Sbjct: 1144 LSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEE--ETKNHEAQIQDMRQRH 1201
Query: 517 SILVNGATDYCSLSTSSSETANLNEHVEG--------------QSNLESEPIHQESPARS 562
+ + ++ L + ANL ++ +G +++E H+ +
Sbjct: 1202 ATALEELSE--QLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDA 1259
Query: 563 SPELLPSGVTDENEVTTAVTEKVC---SELDN-----NRHSKEEDPFNVDSSSLTGPVAD 614
+ L + V++ + + + EK +ELDN K+ F D++SL + D
Sbjct: 1260 QVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQD 1319
Query: 615 T 615
T
Sbjct: 1320 T 1320
Score = 62.0 bits (149), Expect = 2e-09
Identities = 46/205 (22%), Positives = 93/205 (45%), Gaps = 32/205 (15%)
Query: 317 QKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRT--------- 367
+KNI+ A+ E + + + ++E + DL+ + + ++R
Sbjct: 888 EKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKK 947
Query: 368 --SEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDE--------------QKAQLEEQ 411
+ +QDL++++ E QKLQ +K + + +++E +K +E++
Sbjct: 948 MQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDR 1007
Query: 412 LKEVRKKCAEEAQLISSLKAELTSQESQISTYEEEL---AKAREELS----RLQQETAEL 464
+ E + AEE + +L QE IS EE L K R+EL +L ET +L
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067
Query: 465 EESVESGKAQLEPLQQHLQDSQQEI 489
++ + +AQ++ L+ L ++E+
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEEL 1092
Score = 53.5 bits (127), Expect = 8e-07
Identities = 48/195 (24%), Positives = 92/195 (47%), Gaps = 18/195 (9%)
Query: 333 KELDTLNNEIVDL-------QREKNNVEQDLKEKEDTIKQRTSEVQ-DLQDEVQRENTNL 384
+EL+ L E+ D Q + EQ++ E + +++ T + +QD QR T L
Sbjct: 1146 EELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATAL 1205
Query: 385 QKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYE 444
++L Q +Q + L++ K LE KE+ A E +++ +KAE + ++
Sbjct: 1206 EELSEQLEQAKRFKANLEKNKQGLETDNKEL----ACEVKVLQQVKAESEHKRKKLDAQV 1261
Query: 445 EELAKAREELSRLQQETAE----LEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
+EL E RL+ E AE L+ +++ LE ++ ++ +S++ +L + +
Sbjct: 1262 QELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQ 1321
Query: 501 DL--ENHNSQLNWCS 513
+L E +LN S
Sbjct: 1322 ELLQEETRQKLNLSS 1336
Score = 53.5 bits (127), Expect = 8e-07
Identities = 44/182 (24%), Positives = 85/182 (46%), Gaps = 20/182 (10%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQ---DLQDEVQRENTNLQKLQ 388
IK++ L E+ D ++++ K+ E +K ++++ +DEV ++ L+KLQ
Sbjct: 1595 IKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQ---LRKLQ 1651
Query: 389 AQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
AQ + Q L+E + ++ Q KE KK I L+ EL S E E+E
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKESEKKLKSLEAEILQLQEELASSERARRHAEQERD 1711
Query: 449 KAREELS--------------RLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQM 494
+ +E++ RL+ A+LEE +E ++ +E L + + ++ ++
Sbjct: 1712 ELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRKTTLQVDTLNA 1771
Query: 495 KL 496
+L
Sbjct: 1772 EL 1773
Score = 52.0 bits (123), Expect = 2e-06
Identities = 35/190 (18%), Positives = 93/190 (48%), Gaps = 21/190 (11%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQ------- 385
+EL + E++ ++ ++ VE +L+E E +Q E L +++Q E
Sbjct: 852 EELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRA 911
Query: 386 KLQAQKQQVQELLDELDE--------------QKAQLEEQLKEVRKKCAEEAQLISSLKA 431
+L A+KQ+++E+L +L+ +K +++ ++++ ++ EE L+
Sbjct: 912 RLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQL 971
Query: 432 ELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISS 491
E + E++I EEE+ ++ S+ +E +E+ + +QL ++ ++ + +
Sbjct: 972 EKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNK 1031
Query: 492 MQMKLMEMKD 501
++ + ++++
Sbjct: 1032 QEVMISDLEE 1041
Score = 51.6 bits (122), Expect = 3e-06
Identities = 45/178 (25%), Positives = 87/178 (48%), Gaps = 25/178 (14%)
Query: 335 LDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQV 394
L+ L+ ++ +R K N+E++ + E K+ EV+ LQ +KL AQ Q++
Sbjct: 1205 LEELSEQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264
Query: 395 QELLDELDEQKAQLEEQ--------------LKEVRKKCAEEAQLISSLKAELTSQESQI 440
+ E D + +L E+ L+E KK + A+ +SL+++L Q++Q
Sbjct: 1265 HAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQL--QDTQE 1322
Query: 441 STYEE---------ELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEI 489
EE + + EE + LQ++ E EE+ ++ + Q+ LQ L D+++++
Sbjct: 1323 LLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKV 1380
Score = 50.4 bits (119), Expect = 7e-06
Identities = 40/191 (20%), Positives = 86/191 (45%), Gaps = 18/191 (9%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQK----LQ 388
K+LD E+ E + + +L EK ++ V L +E +++ K L+
Sbjct: 1255 KKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLE 1314
Query: 389 AQKQQVQELLDELDEQKA-------QLEEQLKEVRKKCAEEAQLISSLKAELTSQESQIS 441
+Q Q QELL E QK QLEE+ ++++ EE + +L+ ++ + +SQ++
Sbjct: 1315 SQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLA 1374
Query: 442 TYEEE-------LAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQM 494
+++ + E +L ++ L + +E + L++ QQE+ + +
Sbjct: 1375 DTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTV 1434
Query: 495 KLMEMKDLENH 505
L + + ++
Sbjct: 1435 DLDHQRQVASN 1445
Score = 50.4 bits (119), Expect = 7e-06
Identities = 48/189 (25%), Positives = 86/189 (45%), Gaps = 18/189 (9%)
Query: 332 IKELDTLNNEIVD----LQREKNNVEQDLKEKEDT-------IKQRTSEVQDLQDEVQRE 380
+ E D L E+ + LQ E +NV L+E E S++QD Q+ +Q E
Sbjct: 1268 VSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEE 1327
Query: 381 NTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQI 440
L ++ +Q++E + L EQ+ + EE K + K+ ++ K ++ I
Sbjct: 1328 TRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTI 1387
Query: 441 STYEE---ELAKAREELSRLQQETA----ELEESVESGKAQLEPLQQHLQDSQQEISSMQ 493
+ EE +L K E LS+ +E A +LE++ + +L+ L L +Q S+++
Sbjct: 1388 ESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVDLDHQRQVASNLE 1447
Query: 494 MKLMEMKDL 502
K + L
Sbjct: 1448 KKQKKFDQL 1456
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/168 (20%), Positives = 78/168 (46%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
++L+ +L++ K +E D KE +K + + + ++ + +Q+L A+
Sbjct: 1210 EQLEQAKRFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVS 1269
Query: 393 QVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKARE 452
+ L EL E+ ++L+ +L V E + + S ESQ+ +E L +
Sbjct: 1270 EGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETR 1329
Query: 453 ELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK 500
+ L +LEE S + Q E ++ ++ ++++ ++Q +L + K
Sbjct: 1330 QKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTK 1377
Score = 48.5 bits (114), Expect = 3e-05
Identities = 47/223 (21%), Positives = 95/223 (42%), Gaps = 47/223 (21%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQ 392
K++ L +++ D +++ ++ ++ E+ K+ + + L ++ + KL+ K
Sbjct: 1364 KQVLALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN 1423
Query: 393 QVQELLD----ELDEQK---AQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYE- 444
++Q+ LD +LD Q+ + LE++ K+ + AEE + + E E++ E
Sbjct: 1424 RLQQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKET 1483
Query: 445 ---------EELAKAREELSR-------------------------LQQETAELEESVES 470
EE +A+EE R L++ LE+ VE
Sbjct: 1484 KALSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEE 1543
Query: 471 GKAQLEPLQQHLQDSQQ-----EISSMQMKLMEMKDLENHNSQ 508
+ QLE L+ LQ ++ E++ MK +DL+ + Q
Sbjct: 1544 MRTQLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQ 1586
Score = 48.5 bits (114), Expect = 3e-05
Identities = 37/178 (20%), Positives = 83/178 (46%), Gaps = 9/178 (5%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKE------KEDTIKQRTSEVQDLQD-EVQRENTNLQ 385
+ELD L ++ ++ +N+E+ K+ +E +I R +E +D + E + + T
Sbjct: 1427 QELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKAL 1486
Query: 386 KLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEE 445
L ++ E +E + Q QL ++++ + + + L+ + E Q+
Sbjct: 1487 SLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMRT 1546
Query: 446 ELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLE 503
+L + +EL + LE ++++ KAQ E Q + +E + +K ++++LE
Sbjct: 1547 QLEELEDELQATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIK--QVRELE 1602
Score = 47.0 bits (110), Expect = 8e-05
Identities = 40/191 (20%), Positives = 90/191 (47%), Gaps = 32/191 (16%)
Query: 343 VDLQREKNNVEQDLKEKEDTIKQRT----SEVQDLQDEVQRENT--------------NL 384
V++Q K E+DL+ +++ +++ +V++L+ E++ E +L
Sbjct: 1567 VNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEIDL 1626
Query: 385 QKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYE 444
+ L+AQ + + DE+ +Q +L+ Q+K+ +++ E + A+ E ++ + E
Sbjct: 1627 KDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSLE 1686
Query: 445 EELAKAREELS-------RLQQETAELEESV---ESGKAQL----EPLQQHLQDSQQEIS 490
E+ + +EEL+ +QE EL + + SGK+ L L+ + ++E+
Sbjct: 1687 AEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELE 1746
Query: 491 SMQMKLMEMKD 501
Q + + D
Sbjct: 1747 EEQSNMELLND 1757
Score = 47.0 bits (110), Expect = 8e-05
Identities = 46/207 (22%), Positives = 92/207 (44%), Gaps = 30/207 (14%)
Query: 312 DRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQRE-------KNNVEQDLKEKEDTIK 364
D L+ I ++ D IK+L L ++ D QRE ++ + KE E +K
Sbjct: 1625 DLKDLEAQIEAANKARD-EVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLK 1683
Query: 365 QRTSEVQDLQDEVQRENTNLQKLQAQKQQVQE-----------LLDE---LDEQKAQLEE 410
+E+ LQ+E+ + + ++ ++ + LLDE L+ + AQLEE
Sbjct: 1684 SLEAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEE 1743
Query: 411 QLKE-------VRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463
+L+E + + + + +L AEL ++ S + + + L+ + E
Sbjct: 1744 ELEEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQE 1803
Query: 464 LEESVESG-KAQLEPLQQHLQDSQQEI 489
LE +V+S KA + L+ + ++++
Sbjct: 1804 LEGAVKSKFKATISALEAKIGQLEEQL 1830
Score = 44.7 bits (104), Expect = 4e-04
Identities = 35/151 (23%), Positives = 76/151 (50%), Gaps = 11/151 (7%)
Query: 369 EVQDLQDEVQRENTNLQKLQAQKQQVQELLDELD-------EQKAQLEEQLKEVRKKCAE 421
+V ++E+Q ++ L K++ ++ +V+ L+E++ E+K L EQL+ + AE
Sbjct: 846 QVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETELFAE 905
Query: 422 EAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQH 481
++ + L A+ E + E + + E LQ E +++ ++ + QL+ +
Sbjct: 906 AEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGA 965
Query: 482 LQDSQQEISSMQMKLMEMKD----LENHNSQ 508
Q Q E + + K+ +M++ LE+ NS+
Sbjct: 966 RQKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996
>gi|125625326 RALBP1 associated Eps domain containing 2 isoform 1
[Homo sapiens]
Length = 660
Score = 65.5 bits (158), Expect = 2e-10
Identities = 38/102 (37%), Positives = 48/102 (47%), Gaps = 1/102 (0%)
Query: 111 LISGTSAAELPWAVKPEDKAKYDAIFDSLSP-VNGFLSGDKVKPVLLNSKLPVDILGRVW 169
L +S + PW + E + Y F SL P + F+SG K SKL + L +W
Sbjct: 265 LQDNSSYPDEPWRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIW 324
Query: 170 ELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVP 211
ELSD D DG L EF A L+ P+P LPP L P
Sbjct: 325 ELSDADCDGALTLPEFCAAFHLIVARKNGYPLPEGLPPTLQP 366
Score = 48.9 bits (115), Expect = 2e-05
Identities = 39/144 (27%), Positives = 60/144 (41%), Gaps = 10/144 (6%)
Query: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
W ++ ++ Y F D F+SG + F K+ L L++IW L D G L
Sbjct: 276 WRITEEQREYYVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGAL 335
Query: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVAD---FSAIKE 334
+ +F AFHLI + G P L P + P +A+ K P D F + E
Sbjct: 336 TLPEFCAAFHLIVARK-NGYPLPEGLPPTLQPEYLQAAFPK------PKWDCQLFDSYSE 388
Query: 335 LDTLNNEIVDLQREKNNVEQDLKE 358
N + DL R + +D+ +
Sbjct: 389 SLPANQQPRDLNRMEKTSVKDMAD 412
Score = 47.0 bits (110), Expect = 8e-05
Identities = 25/73 (34%), Positives = 37/73 (50%)
Query: 31 TGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVS 90
T A A + S LP L +I +L G +F++AL+L+A AQ+GL V
Sbjct: 67 TATAAAGPVADLFRASQLPAETLHQITELCGAKRVGYFGPTQFYIALKLIAAAQSGLPVR 126
Query: 91 LSSLNLAVPPPRF 103
+ S+ +P PRF
Sbjct: 127 IESIKCELPLPRF 139
Score = 39.3 bits (90), Expect = 0.017
Identities = 38/155 (24%), Positives = 55/155 (35%), Gaps = 9/155 (5%)
Query: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Y +R + + + S A F KS L L IW+L+D D G L EF A
Sbjct: 286 YVNQFRSLQPDPSSFISGSVAKNFFTKSKLSIPELSYIWELSDADCDGALTLPEFCAAFH 345
Query: 79 LVACAQNGL--------EVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKA 130
L+ +NG + L A P P++ A + P + +K
Sbjct: 346 LIVARKNGYPLPEGLPPTLQPEYLQAAFPKPKWDCQLFDSYSESLPANQQPRDLNRMEKT 405
Query: 131 KYDAIFDSLSPVNGFLSGDK-VKPVLLNSKLPVDI 164
+ D P S DK +N LP D+
Sbjct: 406 SVKDMADLPVPNQDVTSDDKQALKSTINEALPKDV 440
Score = 30.4 bits (67), Expect = 7.7
Identities = 29/130 (22%), Positives = 49/130 (37%), Gaps = 20/130 (15%)
Query: 771 LPPKIGTPTRPCP-----------LPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKD 819
LPP P RPCP LP R+ ++ P K + + P ++
Sbjct: 512 LPPPPALPPRPCPSQSEQVSEAELLPQLSRAPSQAAESSPAKKDVLYSQPPSKPIRRKFR 571
Query: 820 PEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKR------ESEREEEQRLAR 873
PE + T + + P++ A +P+ + K+ +E LAR
Sbjct: 572 PE---NQATENQEPSTAASGPASAATMKPHPTVQKQSSKQKKAIQTAIRKNKEANAVLAR 628
Query: 874 LNQQEQEDLE 883
LN + Q+ L+
Sbjct: 629 LNSELQQQLK 638
>gi|205277396 dynactin 1 isoform 4 [Homo sapiens]
Length = 1139
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/158 (29%), Positives = 86/158 (54%), Gaps = 14/158 (8%)
Query: 354 QDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLK 413
+DL+EK +T++ + +E + E L+K + Q +QVQE ++ EQ+A L+ +LK
Sbjct: 91 RDLEEKLETLRLKRAEDKAKLKE-------LEKHKIQLEQVQEWKSKMQEQQADLQRRLK 143
Query: 414 EVRKKCAEEAQLISSLKAEL--TSQESQISTYEEELAKAREELSRLQQETAELEESVESG 471
E RK+ E + E+ T+ +++T ++E+A+ R E LQQE L+E V+
Sbjct: 144 EARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAE--SLQQEVEALKERVDEL 201
Query: 472 KAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQL 509
LE L+ +++ + ++ +L K LE N++L
Sbjct: 202 TTDLEILKAEIEEKGSDGAASSYQL---KQLEEQNARL 236
Score = 57.0 bits (136), Expect = 8e-08
Identities = 33/164 (20%), Positives = 82/164 (50%)
Query: 338 LNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQEL 397
+ + DLQR ++ KE + ++ E+ D D ++ + + + + + +Q+
Sbjct: 131 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 190
Query: 398 LDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRL 457
++ L E+ +L L+ ++ + E+ ++ +L E Q + ++ L + R+ S
Sbjct: 191 VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 250
Query: 458 QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+QE +L++ +E +LE ++Q + Q+E+S + + E+K+
Sbjct: 251 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE 294
Score = 48.1 bits (113), Expect = 4e-05
Identities = 39/215 (18%), Positives = 99/215 (46%), Gaps = 18/215 (8%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEV------QDLQDEVQRENTNLQK 386
K ++ N E+ +++++ ++++L + E TI + +V +++ + + N NL++
Sbjct: 259 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEE 318
Query: 387 LQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL----ISSLKAELTSQESQIST 442
+ ++ L+ ++E +L+E +E + E+ + + + + + + ++
Sbjct: 319 KVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
Query: 443 YEEELAKAREELSRLQQETAELEESVE-SGKAQLEP------LQQHLQDSQQEISSMQMK 495
Y++ + K R+ + LQ EL E S + Q +P + +++ +++M+
Sbjct: 379 YQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 438
Query: 496 LMEMKDLE-NHNSQLNWCSSPHSILVNGATDYCSL 529
L +M+ + N + L P S L G C L
Sbjct: 439 LRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVL 473
Score = 40.0 bits (92), Expect = 0.010
Identities = 37/209 (17%), Positives = 101/209 (48%), Gaps = 31/209 (14%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ---- 388
+E++ L + +L + ++ +++EK + +++ L+++ R L +++
Sbjct: 189 QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 248
Query: 389 AQKQQ---VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLK----AELTSQE---- 437
++KQ+ +Q+L+++ +++ + +Q + ++++ ++ I LK A L ++E
Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 308
Query: 438 --SQISTYEEELAKAREELSRLQ---------QETA-----ELEESVESGKAQLEPLQQH 481
+ EE++ + RE + L+ QE A EL E ++ A++ Q+
Sbjct: 309 LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 368
Query: 482 LQDSQQEISSMQMKLMEMKDLENHNSQLN 510
++ +Q+ ++ Q + + + L H +N
Sbjct: 369 VEAAQETVADYQQTIKKYRQLTAHLQDVN 397
Score = 34.7 bits (78), Expect = 0.41
Identities = 26/109 (23%), Positives = 53/109 (48%), Gaps = 8/109 (7%)
Query: 356 LKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDE-LDEQKAQLEEQLKE 414
L+++E IK+ ++ +E+ N L L+ + + DE +++ + +LEE
Sbjct: 811 LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQAL 870
Query: 415 VRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463
+RKK E + + +L+A+ I E E A+ ++ L+ + T E
Sbjct: 871 LRKKEKEFEETMDALQAD-------IDQLEAEKAELKQRLNSQSKRTIE 912
>gi|205277392 dynactin 1 isoform 3 [Homo sapiens]
Length = 1253
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/158 (29%), Positives = 86/158 (54%), Gaps = 14/158 (8%)
Query: 354 QDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLK 413
+DL+EK +T++ + +E + E L+K + Q +QVQE ++ EQ+A L+ +LK
Sbjct: 205 RDLEEKLETLRLKRAEDKAKLKE-------LEKHKIQLEQVQEWKSKMQEQQADLQRRLK 257
Query: 414 EVRKKCAEEAQLISSLKAEL--TSQESQISTYEEELAKAREELSRLQQETAELEESVESG 471
E RK+ E + E+ T+ +++T ++E+A+ R E LQQE L+E V+
Sbjct: 258 EARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAE--SLQQEVEALKERVDEL 315
Query: 472 KAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQL 509
LE L+ +++ + ++ +L K LE N++L
Sbjct: 316 TTDLEILKAEIEEKGSDGAASSYQL---KQLEEQNARL 350
Score = 57.0 bits (136), Expect = 8e-08
Identities = 33/164 (20%), Positives = 82/164 (50%)
Query: 338 LNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQEL 397
+ + DLQR ++ KE + ++ E+ D D ++ + + + + + +Q+
Sbjct: 245 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 304
Query: 398 LDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRL 457
++ L E+ +L L+ ++ + E+ ++ +L E Q + ++ L + R+ S
Sbjct: 305 VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 364
Query: 458 QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+QE +L++ +E +LE ++Q + Q+E+S + + E+K+
Sbjct: 365 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE 408
Score = 48.1 bits (113), Expect = 4e-05
Identities = 39/215 (18%), Positives = 99/215 (46%), Gaps = 18/215 (8%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEV------QDLQDEVQRENTNLQK 386
K ++ N E+ +++++ ++++L + E TI + +V +++ + + N NL++
Sbjct: 373 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEE 432
Query: 387 LQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL----ISSLKAELTSQESQIST 442
+ ++ L+ ++E +L+E +E + E+ + + + + + + ++
Sbjct: 433 KVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 492
Query: 443 YEEELAKAREELSRLQQETAELEESVE-SGKAQLEP------LQQHLQDSQQEISSMQMK 495
Y++ + K R+ + LQ EL E S + Q +P + +++ +++M+
Sbjct: 493 YQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 552
Query: 496 LMEMKDLE-NHNSQLNWCSSPHSILVNGATDYCSL 529
L +M+ + N + L P S L G C L
Sbjct: 553 LRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVL 587
Score = 40.0 bits (92), Expect = 0.010
Identities = 37/209 (17%), Positives = 101/209 (48%), Gaps = 31/209 (14%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ---- 388
+E++ L + +L + ++ +++EK + +++ L+++ R L +++
Sbjct: 303 QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 362
Query: 389 AQKQQ---VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLK----AELTSQE---- 437
++KQ+ +Q+L+++ +++ + +Q + ++++ ++ I LK A L ++E
Sbjct: 363 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 422
Query: 438 --SQISTYEEELAKAREELSRLQ---------QETA-----ELEESVESGKAQLEPLQQH 481
+ EE++ + RE + L+ QE A EL E ++ A++ Q+
Sbjct: 423 LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 482
Query: 482 LQDSQQEISSMQMKLMEMKDLENHNSQLN 510
++ +Q+ ++ Q + + + L H +N
Sbjct: 483 VEAAQETVADYQQTIKKYRQLTAHLQDVN 511
Score = 34.7 bits (78), Expect = 0.41
Identities = 26/109 (23%), Positives = 53/109 (48%), Gaps = 8/109 (7%)
Query: 356 LKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDE-LDEQKAQLEEQLKE 414
L+++E IK+ ++ +E+ N L L+ + + DE +++ + +LEE
Sbjct: 925 LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQAL 984
Query: 415 VRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463
+RKK E + + +L+A+ I E E A+ ++ L+ + T E
Sbjct: 985 LRKKEKEFEETMDALQAD-------IDQLEAEKAELKQRLNSQSKRTIE 1026
>gi|13259508 dynactin 1 isoform 2 [Homo sapiens]
Length = 1144
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/158 (29%), Positives = 86/158 (54%), Gaps = 14/158 (8%)
Query: 354 QDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLK 413
+DL+EK +T++ + +E + E L+K + Q +QVQE ++ EQ+A L+ +LK
Sbjct: 91 RDLEEKLETLRLKRAEDKAKLKE-------LEKHKIQLEQVQEWKSKMQEQQADLQRRLK 143
Query: 414 EVRKKCAEEAQLISSLKAEL--TSQESQISTYEEELAKAREELSRLQQETAELEESVESG 471
E RK+ E + E+ T+ +++T ++E+A+ R E LQQE L+E V+
Sbjct: 144 EARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAE--SLQQEVEALKERVDEL 201
Query: 472 KAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQL 509
LE L+ +++ + ++ +L K LE N++L
Sbjct: 202 TTDLEILKAEIEEKGSDGAASSYQL---KQLEEQNARL 236
Score = 57.0 bits (136), Expect = 8e-08
Identities = 33/164 (20%), Positives = 82/164 (50%)
Query: 338 LNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQEL 397
+ + DLQR ++ KE + ++ E+ D D ++ + + + + + +Q+
Sbjct: 131 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 190
Query: 398 LDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRL 457
++ L E+ +L L+ ++ + E+ ++ +L E Q + ++ L + R+ S
Sbjct: 191 VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 250
Query: 458 QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+QE +L++ +E +LE ++Q + Q+E+S + + E+K+
Sbjct: 251 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE 294
Score = 48.1 bits (113), Expect = 4e-05
Identities = 39/215 (18%), Positives = 99/215 (46%), Gaps = 18/215 (8%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEV------QDLQDEVQRENTNLQK 386
K ++ N E+ +++++ ++++L + E TI + +V +++ + + N NL++
Sbjct: 259 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEE 318
Query: 387 LQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL----ISSLKAELTSQESQIST 442
+ ++ L+ ++E +L+E +E + E+ + + + + + + ++
Sbjct: 319 KVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 378
Query: 443 YEEELAKAREELSRLQQETAELEESVE-SGKAQLEP------LQQHLQDSQQEISSMQMK 495
Y++ + K R+ + LQ EL E S + Q +P + +++ +++M+
Sbjct: 379 YQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 438
Query: 496 LMEMKDLE-NHNSQLNWCSSPHSILVNGATDYCSL 529
L +M+ + N + L P S L G C L
Sbjct: 439 LRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVL 473
Score = 40.0 bits (92), Expect = 0.010
Identities = 37/209 (17%), Positives = 101/209 (48%), Gaps = 31/209 (14%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ---- 388
+E++ L + +L + ++ +++EK + +++ L+++ R L +++
Sbjct: 189 QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 248
Query: 389 AQKQQ---VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLK----AELTSQE---- 437
++KQ+ +Q+L+++ +++ + +Q + ++++ ++ I LK A L ++E
Sbjct: 249 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 308
Query: 438 --SQISTYEEELAKAREELSRLQ---------QETA-----ELEESVESGKAQLEPLQQH 481
+ EE++ + RE + L+ QE A EL E ++ A++ Q+
Sbjct: 309 LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 368
Query: 482 LQDSQQEISSMQMKLMEMKDLENHNSQLN 510
++ +Q+ ++ Q + + + L H +N
Sbjct: 369 VEAAQETVADYQQTIKKYRQLTAHLQDVN 397
Score = 34.7 bits (78), Expect = 0.41
Identities = 26/109 (23%), Positives = 53/109 (48%), Gaps = 8/109 (7%)
Query: 356 LKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDE-LDEQKAQLEEQLKE 414
L+++E IK+ ++ +E+ N L L+ + + DE +++ + +LEE
Sbjct: 811 LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQAL 870
Query: 415 VRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463
+RKK E + + +L+A+ I E E A+ ++ L+ + T E
Sbjct: 871 LRKKEKEFEETMDALQAD-------IDQLEAEKAELKQRLNSQSKRTIE 912
>gi|13259510 dynactin 1 isoform 1 [Homo sapiens]
Length = 1278
Score = 65.1 bits (157), Expect = 3e-10
Identities = 47/158 (29%), Positives = 86/158 (54%), Gaps = 14/158 (8%)
Query: 354 QDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLK 413
+DL+EK +T++ + +E + E L+K + Q +QVQE ++ EQ+A L+ +LK
Sbjct: 225 RDLEEKLETLRLKRAEDKAKLKE-------LEKHKIQLEQVQEWKSKMQEQQADLQRRLK 277
Query: 414 EVRKKCAEEAQLISSLKAEL--TSQESQISTYEEELAKAREELSRLQQETAELEESVESG 471
E RK+ E + E+ T+ +++T ++E+A+ R E LQQE L+E V+
Sbjct: 278 EARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAE--SLQQEVEALKERVDEL 335
Query: 472 KAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQL 509
LE L+ +++ + ++ +L K LE N++L
Sbjct: 336 TTDLEILKAEIEEKGSDGAASSYQL---KQLEEQNARL 370
Score = 57.0 bits (136), Expect = 8e-08
Identities = 33/164 (20%), Positives = 82/164 (50%)
Query: 338 LNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQEL 397
+ + DLQR ++ KE + ++ E+ D D ++ + + + + + +Q+
Sbjct: 265 MQEQQADLQRRLKEARKEAKEALEAKERYMEEMADTADAIEMATLDKEMAEERAESLQQE 324
Query: 398 LDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRL 457
++ L E+ +L L+ ++ + E+ ++ +L E Q + ++ L + R+ S
Sbjct: 325 VEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSSSE 384
Query: 458 QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKD 501
+QE +L++ +E +LE ++Q + Q+E+S + + E+K+
Sbjct: 385 KQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKE 428
Score = 48.1 bits (113), Expect = 4e-05
Identities = 39/215 (18%), Positives = 99/215 (46%), Gaps = 18/215 (8%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEV------QDLQDEVQRENTNLQK 386
K ++ N E+ +++++ ++++L + E TI + +V +++ + + N NL++
Sbjct: 393 KLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEMLTDRNLNLEE 452
Query: 387 LQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQL----ISSLKAELTSQESQIST 442
+ ++ L+ ++E +L+E +E + E+ + + + + + + ++
Sbjct: 453 KVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKRVEAAQETVAD 512
Query: 443 YEEELAKAREELSRLQQETAELEESVE-SGKAQLEP------LQQHLQDSQQEISSMQMK 495
Y++ + K R+ + LQ EL E S + Q +P + +++ +++M+
Sbjct: 513 YQQTIKKYRQLTAHLQDVNRELTNQQEASVERQQQPPPETFDFKIKFAETKAHAKAIEME 572
Query: 496 LMEMKDLE-NHNSQLNWCSSPHSILVNGATDYCSL 529
L +M+ + N + L P S L G C L
Sbjct: 573 LRQMEVAQANRHMSLLTAFMPDSFLRPGGDHDCVL 607
Score = 40.0 bits (92), Expect = 0.010
Identities = 37/209 (17%), Positives = 101/209 (48%), Gaps = 31/209 (14%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQ---- 388
+E++ L + +L + ++ +++EK + +++ L+++ R L +++
Sbjct: 323 QEVEALKERVDELTTDLEILKAEIEEKGSDGAASSYQLKQLEEQNARLKDALVRMRDLSS 382
Query: 389 AQKQQ---VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLK----AELTSQE---- 437
++KQ+ +Q+L+++ +++ + +Q + ++++ ++ I LK A L ++E
Sbjct: 383 SEKQEHVKLQKLMEKKNQELEVVRQQRERLQEELSQAESTIDELKEQVDAALGAEEMVEM 442
Query: 438 --SQISTYEEELAKAREELSRLQ---------QETA-----ELEESVESGKAQLEPLQQH 481
+ EE++ + RE + L+ QE A EL E ++ A++ Q+
Sbjct: 443 LTDRNLNLEEKVRELRETVGDLEAMNEMNDELQENARETELELREQLDMAGARVREAQKR 502
Query: 482 LQDSQQEISSMQMKLMEMKDLENHNSQLN 510
++ +Q+ ++ Q + + + L H +N
Sbjct: 503 VEAAQETVADYQQTIKKYRQLTAHLQDVN 531
Score = 34.7 bits (78), Expect = 0.41
Identities = 26/109 (23%), Positives = 53/109 (48%), Gaps = 8/109 (7%)
Query: 356 LKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDE-LDEQKAQLEEQLKE 414
L+++E IK+ ++ +E+ N L L+ + + DE +++ + +LEE
Sbjct: 945 LEDRETVIKELKKSLKIKGEELSEANVRLSLLEKKLDSAAKDADERIEKVQTRLEETQAL 1004
Query: 415 VRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAE 463
+RKK E + + +L+A+ I E E A+ ++ L+ + T E
Sbjct: 1005 LRKKEKEFEETMDALQAD-------IDQLEAEKAELKQRLNSQSKRTIE 1046
>gi|38044112 restin isoform b [Homo sapiens]
Length = 1392
Score = 64.7 bits (156), Expect = 4e-10
Identities = 72/305 (23%), Positives = 130/305 (42%), Gaps = 42/305 (13%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQ- 390
IK + L N+I ++ + + L + D ++ + +V++LQ ++ + N N LQ
Sbjct: 874 IKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLKERDVEELQLKLTKANENASFLQKSI 933
Query: 391 -------KQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTY 443
+Q QE + +E+K +LE +L ++ KK LKA S+ T
Sbjct: 934 EDMTVKAEQSQQEAAKKHEEEKKELERKLSDLEKKMETSHNQCQELKARYERATSETKTK 993
Query: 444 EEELAK---------------AREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQE 488
EE+ + AREE S L QE EL + + KA + + +Q +Q
Sbjct: 994 HEEILQNLQKTLLDTEDKLKGAREENSGLLQELEELRKQADKAKA-AQTAEDAMQIMEQM 1052
Query: 489 ISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSN 548
L ++D + N++L + ++ N + L+ S N+ +E +
Sbjct: 1053 TKEKTETLASLEDTKQTNAKLQ--NELDTLKENNLKNVEELNKSKELLTVENQKME-EFR 1109
Query: 549 LESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNR-----HSKEEDPFNV 603
E E + Q + A+ S +L S + +EN K+ EL +R H K E+ +V
Sbjct: 1110 KEIETLKQ-AAAQKSQQL--SALQEEN-------VKLAEELGRSRDEVTSHQKLEEERSV 1159
Query: 604 DSSSL 608
++ L
Sbjct: 1160 LNNQL 1164
Score = 57.8 bits (138), Expect = 4e-08
Identities = 46/204 (22%), Positives = 97/204 (47%), Gaps = 22/204 (10%)
Query: 333 KELDTLNNEIVDLQREKNNVEQDLKEKEDTIK-QRTSEVQDLQDEVQRENTN---LQKLQ 388
KE++ L +++ + +EK N + ++ K D + Q E++D +++Q L+ LQ
Sbjct: 644 KEMEALRAKLMKVIKEKENSLEAIRSKLDKAEDQHLVEMEDTLNKLQEAEIKVKELEVLQ 703
Query: 389 AQKQQVQELLDELDEQKAQLEEQL-----------------KEVRKKCAEEAQLISSLKA 431
A+ + +++D Q EE+L K++R++ + I L+
Sbjct: 704 AKCNEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEI 763
Query: 432 ELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISS 491
E ++ S+ S+ EL +L+ LQ+ +E+ + E+ + +L+ L++ ++ +E S
Sbjct: 764 EKNAESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEASEEAVS 823
Query: 492 MQMKLME-MKDLENHNSQLNWCSS 514
+Q + E + L Q N SS
Sbjct: 824 VQRSMQETVNKLHQKEEQFNMLSS 847
Score = 57.4 bits (137), Expect = 6e-08
Identities = 45/202 (22%), Positives = 101/202 (50%), Gaps = 22/202 (10%)
Query: 315 SLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQ 374
+LQ+N+ S V + + KEL L + + E +V++ ++E + + Q+ + L
Sbjct: 788 NLQENLSEVSQVKE-TLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLS 846
Query: 375 DEVQRENTNLQKLQAQKQQVQELLDELDEQ-------KAQLEEQLKEVRKKCAEEAQLIS 427
++++ NL ++A+ + E DE+ K +LE + E+ K + + ++
Sbjct: 847 SDLEKLRENLADMEAKFR-------EKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLT 899
Query: 428 SLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQ 487
+ EL +E + + +L KA E S LQ+ ++ +V++ ++Q E ++H ++
Sbjct: 900 KMNDELRLKERDVEELQLKLTKANENASFLQKSIEDM--TVKAEQSQQEAAKKH----EE 953
Query: 488 EISSMQMKLMEM-KDLENHNSQ 508
E ++ KL ++ K +E ++Q
Sbjct: 954 EKKELERKLSDLEKKMETSHNQ 975
Score = 55.1 bits (131), Expect = 3e-07
Identities = 59/253 (23%), Positives = 119/253 (47%), Gaps = 24/253 (9%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQK 391
+K ++ LN L E +E+ KE E T+KQ ++ +Q EN L + +
Sbjct: 1085 LKNVEELNKSKELLTVENQKMEEFRKEIE-TLKQAAAQKSQQLSALQEENVKLAEELGRS 1143
Query: 392 QQVQELLDELDEQKAQLEEQLKEVRK------KCAEEAQLISSLKAELTSQESQISTYEE 445
+ +L+E+++ L QL E++K K A+E + +SL+ ++ + ++ +
Sbjct: 1144 RDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEK--ASLQKSISITSALLTEKDA 1201
Query: 446 ELAKAREELSRLQQETAELE------ESVESGKAQLE----PLQQHLQDSQQEISSMQMK 495
EL K R E++ L+ E A + +++ES K +LE L+ L+++++++SS
Sbjct: 1202 ELEKLRNEVTVLRGENASAKSLHSVVQTLESDKVKLELKVKNLELQLKENKRQLSSSSGN 1261
Query: 496 LMEMKDLENHNSQLNWCSSPHSILVN--GATDYCSLSTSSSETANLNEHVEGQSNLESEP 553
D E+ +Q + +S++V+ + A LN + + +N +S+
Sbjct: 1262 TDTQAD-EDERAQESQIDFLNSVIVDLQRKNQDLKMKVEMMSEAALNGNGDDLNNYDSD- 1319
Query: 554 IHQESPARSSPEL 566
QE ++ P L
Sbjct: 1320 -DQEKQSKKKPRL 1331
Score = 50.1 bits (118), Expect = 9e-06
Identities = 41/196 (20%), Positives = 83/196 (42%), Gaps = 28/196 (14%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQ 393
+LD L + + E + Q L+ E IK E + LQ + +
Sbjct: 729 DLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKNAESSKASSITRELQGRELKLTN 788
Query: 394 VQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKA-------ELTSQESQISTYEEE 446
+QE L E+ + K LE++L+ +++K AE ++ S++ +L +E Q + +
Sbjct: 789 LQENLSEVSQVKETLEKELQILKEKFAEASEEAVSVQRSMQETVNKLHQKEEQFNMLSSD 848
Query: 447 LAKAREELS---------------------RLQQETAELEESVESGKAQLEPLQQHLQDS 485
L K RE L+ +L+ + AE+ + +QL + L+
Sbjct: 849 LEKLRENLADMEAKFREKDEREEQLIKAKEKLENDIAEIMKMSGDNSSQLTKMNDELRLK 908
Query: 486 QQEISSMQMKLMEMKD 501
++++ +Q+KL + +
Sbjct: 909 ERDVEELQLKLTKANE 924
Score = 48.1 bits (113), Expect = 4e-05
Identities = 42/175 (24%), Positives = 81/175 (46%), Gaps = 18/175 (10%)
Query: 332 IKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQK 391
++EL+ L + D + E ++ E K++T + L+D Q +L K
Sbjct: 1023 LQELEELRKQ-ADKAKAAQTAEDAMQIMEQMTKEKTETLASLEDTKQTNAKLQNELDTLK 1081
Query: 392 QQVQELLDELDEQKAQL---EEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELA 448
+ + ++EL++ K L ++++E RK+ I +LK + Q+S +EE
Sbjct: 1082 ENNLKNVEELNKSKELLTVENQKMEEFRKE-------IETLKQAAAQKSQQLSALQEENV 1134
Query: 449 KAREELSRLQQETA---ELEESVESGKAQLEPLQQH----LQDSQQEISSMQMKL 496
K EEL R + E +LEE QL +++ ++D+ +E +S+Q +
Sbjct: 1135 KLAEELGRSRDEVTSHQKLEEERSVLNNQLLEMKKRESKFIKDADEEKASLQKSI 1189
Score = 41.6 bits (96), Expect = 0.003
Identities = 46/220 (20%), Positives = 96/220 (43%), Gaps = 44/220 (20%)
Query: 345 LQREKNNVEQDLKEKE---DTIKQRTSEVQDLQDEV----QRENTNLQKLQAQKQQVQEL 397
L+ ++ ++EQ L E++ + + TS V +++ E+ + ++ +L+A+ Q++ +
Sbjct: 357 LKEKQQHIEQLLAERDLERAEVAKATSHVGEIEQELALARDGHDQHVLELEAKMDQLRTM 416
Query: 398 LDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRL 457
++ D +K +L QL+E ++K ++ Q EE + K
Sbjct: 417 VEAADREKVELLNQLEEEKRKV----------------EDLQFRVEEESITKG------- 453
Query: 458 QQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMK---DLENHNSQLNWCSS 514
+LE + S K+++ L++ L QE++ ++ +L K D++ S L SS
Sbjct: 454 -----DLEVATVSEKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISS 508
Query: 515 PHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPI 554
L TD+ E +L EH + + I
Sbjct: 509 LQEKLEVTRTDH------QREITSLKEHFGAREETHQKEI 542
Score = 38.5 bits (88), Expect = 0.028
Identities = 44/195 (22%), Positives = 83/195 (42%), Gaps = 35/195 (17%)
Query: 334 ELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQ 393
++D L + REK + L+E++ +V+DLQ V+ E+ L+
Sbjct: 409 KMDQLRTMVEAADREKVELLNQLEEEK-------RKVEDLQFRVEEESITKGDLEVATVS 461
Query: 394 VQELLDELDEQKAQLEEQLKEVRKKCAEE------------AQLISSLKAEL----TSQE 437
+ + EL++ A +++ E+R++ Q ISSL+ +L T +
Sbjct: 462 EKSRIMELEKDLALRVQEVAELRRRLESNKPAGDVDMSLSLLQEISSLQEKLEVTRTDHQ 521
Query: 438 SQISTYEEELAKARE----ELSRLQQETAELEESVESGKAQLEPLQQHLQD--------S 485
+I++ +E E E+ L T +L + ES K++LE + D
Sbjct: 522 REITSLKEHFGAREETHQKEIKALYTATEKLSKENESLKSKLEHANKENSDVIALWKSKL 581
Query: 486 QQEISSMQMKLMEMK 500
+ I+S Q + E+K
Sbjct: 582 ETAIASHQQAMEELK 596
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.128 0.362
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,419,768
Number of Sequences: 37866
Number of extensions: 1890116
Number of successful extensions: 27125
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 800
Number of HSP's successfully gapped in prelim test: 1146
Number of HSP's that attempted gapping in prelim test: 9845
Number of HSP's gapped (non-prelim): 10000
length of query: 896
length of database: 18,247,518
effective HSP length: 111
effective length of query: 785
effective length of database: 14,044,392
effective search space: 11024847720
effective search space used: 11024847720
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.