Search of human proteins with 4503097

Search of human proteins with 4503097

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4503097 casein kinase 2, alpha prime polypeptide [Homo
sapiens]
         (350 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens]    722   0.0  
gi|4503095 casein kinase II alpha 1 subunit isoform a [Homo sapi...   602   e-172
gi|29570791 casein kinase II alpha 1 subunit isoform a [Homo sap...   602   e-172
gi|29570793 casein kinase II alpha 1 subunit isoform b [Homo sap...   374   e-104
gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]                   147   2e-35
gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo ...   145   5e-35
gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]         142   3e-34
gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo s...   142   6e-34
gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]        140   2e-33
gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]        139   3e-33
gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]        139   4e-33
gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]                   139   4e-33
gi|7657498 MAPK/MAK/MRK overlapping kinase [Homo sapiens]             135   4e-32
gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]         134   1e-31
gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]         134   1e-31
gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]             134   2e-31
gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]                   132   5e-31
gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]           132   6e-31
gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo sap...   131   8e-31
gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]           130   1e-30
gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]        130   2e-30
gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]        130   2e-30
gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]                    130   2e-30
gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]                   129   4e-30
gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo sapi...   128   7e-30
gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo s...   128   7e-30
gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]                   128   7e-30
gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]        127   1e-29
gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]          127   1e-29
gi|27477122 intestinal cell kinase [Homo sapiens]                     127   2e-29

>gi|4503097 casein kinase 2, alpha prime polypeptide [Homo sapiens]
          Length = 350

 Score =  722 bits (1863), Expect = 0.0
 Identities = 350/350 (100%), Positives = 350/350 (100%)

Query: 1   MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60
           MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI
Sbjct: 1   MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60

Query: 61  TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120
           TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT
Sbjct: 61  TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120

Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180
           DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA
Sbjct: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180

Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240
           EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY
Sbjct: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240

Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300
           DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD
Sbjct: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300

Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350
           LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR
Sbjct: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCADNAVLSSGLTAAR 350


>gi|4503095 casein kinase II alpha 1 subunit isoform a [Homo
           sapiens]
          Length = 391

 Score =  602 bits (1553), Expect = e-172
 Identities = 285/334 (85%), Positives = 309/334 (92%), Gaps = 1/334 (0%)

Query: 1   MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60
           M GP   SRARVY +VN+ R REYWDYE+HV  WGNQDDYQLVRKLGRGKYSEVFEAINI
Sbjct: 1   MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59

Query: 61  TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120
           TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT
Sbjct: 60  TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119

Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180
           DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA
Sbjct: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179

Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240
           EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY
Sbjct: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239

Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300
           DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD
Sbjct: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299

Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQ 334
            LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q++
Sbjct: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQAR 333


>gi|29570791 casein kinase II alpha 1 subunit isoform a [Homo
           sapiens]
          Length = 391

 Score =  602 bits (1553), Expect = e-172
 Identities = 285/334 (85%), Positives = 309/334 (92%), Gaps = 1/334 (0%)

Query: 1   MPGPAAGSRARVYAEVNSLRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINI 60
           M GP   SRARVY +VN+ R REYWDYE+HV  WGNQDDYQLVRKLGRGKYSEVFEAINI
Sbjct: 1   MSGPVP-SRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINI 59

Query: 61  TNNERVVVKILKPVKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT 120
           TNNE+VVVKILKPVKKKKIKRE+KILENLRGG NII L D VKDPVS+TPALVFE++NNT
Sbjct: 60  TNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNT 119

Query: 121 DFKQLYQILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLA 180
           DFKQLYQ LTD+DIRFYMYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLA
Sbjct: 120 DFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLA 179

Query: 181 EFYHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNY 240
           EFYHP QEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNY
Sbjct: 180 EFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNY 239

Query: 241 DQLVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALD 300
           DQLVRIAKVLGTE+LY Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD
Sbjct: 240 DQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALD 299

Query: 301 LLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQ 334
            LDKLLRYDHQ RLTA+EAMEHPYFY VVK+Q++
Sbjct: 300 FLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQAR 333


>gi|29570793 casein kinase II alpha 1 subunit isoform b [Homo
           sapiens]
          Length = 255

 Score =  374 bits (960), Expect = e-104
 Identities = 171/197 (86%), Positives = 186/197 (94%)

Query: 138 MYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRY 197
           MYE+LKALDYCHS GIMHRDVKPHNVMIDH+ +KLRLIDWGLAEFYHP QEYNVRVASRY
Sbjct: 1   MYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRY 60

Query: 198 FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYG 257
           FKGPELLVDYQMYDYSLDMWSLGCMLASMIFR+EPFFHG DNYDQLVRIAKVLGTE+LY 
Sbjct: 61  FKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYD 120

Query: 258 YLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317
           Y+ KY+I+LDP FNDILG+HSRKRWE F+HSEN+HLVSPEALD LDKLLRYDHQ RLTA+
Sbjct: 121 YIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAR 180

Query: 318 EAMEHPYFYPVVKEQSQ 334
           EAMEHPYFY VVK+Q++
Sbjct: 181 EAMEHPYFYTVVKDQAR 197


>gi|4557439 cyclin-dependent kinase 3 [Homo sapiens]
          Length = 305

 Score =  147 bits (370), Expect = 2e-35
 Identities = 98/302 (32%), Positives = 168/302 (55%), Gaps = 31/302 (10%)

Query: 38  DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK------PVKKKKIKREVKILENLRG 91
           D +Q V K+G G Y  V++A N    + V +K ++       V    I RE+ +L+ L+ 
Sbjct: 2   DMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAI-REISLLKELKH 60

Query: 92  GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD-----IRFYMYELLKALD 146
             NI++L+D V +   +   LVFE+++  D K+        +     I+ Y+++LL+ + 
Sbjct: 61  -PNIVRLLDVVHN--ERKLYLVFEFLSQ-DLKKYMDSTPGSELPLHLIKSYLFQLLQGVS 116

Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLV 205
           +CHS  ++HRD+KP N++I+ +   ++L D+GLA  F  P + Y   V + +++ PE+L+
Sbjct: 117 FCHSHRVIHRDLKPQNLLIN-ELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILL 175

Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EELYGYLKKYH 263
             + Y  ++D+WS+GC+ A M+  R+  F G    DQL RI ++LGT  E+ +  + +  
Sbjct: 176 GSKFYTTAVDIWSIGCIFAEMV-TRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQL- 233

Query: 264 IDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323
               P +     + +RK  E  + +     + PE  DLL +LL+YD  QR+TAK A+ HP
Sbjct: 234 ----PDYKGSFPKWTRKGLEEIVPN-----LEPEGRDLLMQLLQYDPSQRITAKTALAHP 284

Query: 324 YF 325
           YF
Sbjct: 285 YF 286


>gi|20986512 mitogen-activated protein kinase 14 isoform 2 [Homo
           sapiens]
          Length = 360

 Score =  145 bits (366), Expect = 5e-35
 Identities = 100/331 (30%), Positives = 172/331 (51%), Gaps = 33/331 (9%)

Query: 24  YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKKK 78
           ++  E +   W   + YQ +  +G G Y  V  A +     RV VK L       +  K+
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 79  IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---------DFKQLY--Q 127
             RE+++L++++   N+I L+D        TPA   E  N+          D   +   Q
Sbjct: 68  TYRELRLLKHMKH-ENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120

Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187
            LTD  ++F +Y++L+ L Y HS  I+HRD+KP N+ + ++  +L+++D+GLA   H   
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV-NEDCELKILDFGLAR--HTDD 177

Query: 188 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247
           E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  R   F G D+ DQL  I 
Sbjct: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR-TLFPGTDHIDQLKLIL 236

Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307
           +++GT      LKK   +   ++   L Q  +  + N     N     P A+DLL+K+L 
Sbjct: 237 RLVGTPGA-ELLKKISSESARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLV 290

Query: 308 YDHQQRLTAKEAMEHPYFYPVVKEQSQPCAD 338
            D  +R+TA +A+ H YF        +P AD
Sbjct: 291 LDSDKRITAAQALAHAYFAQYHDPDDEPVAD 321


>gi|4506085 mitogen-activated protein kinase 13 [Homo sapiens]
          Length = 365

 Score =  142 bits (359), Expect = 3e-34
 Identities = 94/319 (29%), Positives = 172/319 (53%), Gaps = 22/319 (6%)

Query: 19  LRSREYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILK-----P 73
           +R + ++  + +  +W     Y     +G G Y  V  AI+  + E+V +K L       
Sbjct: 4   IRKKGFYKQDVNKTAWELPKTYVSPTHVGSGAYGSVCSAIDKRSGEKVAIKKLSRPFQSE 63

Query: 74  VKKKKIKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYI----NNTDFKQLYQI- 128
           +  K+  RE+ +L++++   N+I L+D V  P S        Y+      TD +++  + 
Sbjct: 64  IFAKRAYRELLLLKHMQH-ENVIGLLD-VFTPASSLRNFYDFYLVMPFMQTDLQKIMGME 121

Query: 129 LTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE 188
            ++  I++ +Y++LK L Y HS G++HRD+KP N+ ++ +  +L+++D+GLA   H   E
Sbjct: 122 FSEEKIQYLVYQMLKGLKYIHSAGVVHRDLKPGNLAVN-EDCELKILDFGLAR--HADAE 178

Query: 189 YNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAK 248
               V +R+++ PE+++ +  Y+ ++D+WS+GC++A M+  +   F G+D  DQL +I K
Sbjct: 179 MTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKT-LFKGKDYLDQLTQILK 237

Query: 249 VLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRY 308
           V G      +++K +      +   L Q  RK +            SP+A DLL+K+L  
Sbjct: 238 VTGVPGTE-FVQKLNDKAAKSYIQSLPQTPRKDFTQLFPR-----ASPQAADLLEKMLEL 291

Query: 309 DHQQRLTAKEAMEHPYFYP 327
           D  +RLTA +A+ HP+F P
Sbjct: 292 DVDKRLTAAQALTHPFFEP 310


>gi|4503069 mitogen-activated protein kinase 14 isoform 1 [Homo
           sapiens]
          Length = 360

 Score =  142 bits (357), Expect = 6e-34
 Identities = 97/331 (29%), Positives = 171/331 (51%), Gaps = 33/331 (9%)

Query: 24  YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKKK 78
           ++  E +   W   + YQ +  +G G Y  V  A +     RV VK L       +  K+
Sbjct: 8   FYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKR 67

Query: 79  IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNT---------DFKQLY--Q 127
             RE+++L++++   N+I L+D        TPA   E  N+          D   +   Q
Sbjct: 68  TYRELRLLKHMKH-ENVIGLLDVF------TPARSLEEFNDVYLVTHLMGADLNNIVKCQ 120

Query: 128 ILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQ 187
            LTD  ++F +Y++L+ L Y HS  I+HRD+KP N+ + ++  +L+++D+GLA   H   
Sbjct: 121 KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAV-NEDCELKILDFGLAR--HTDD 177

Query: 188 EYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIA 247
           E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++  R   F G D+ +QL +I 
Sbjct: 178 EMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGR-TLFPGTDHINQLQQIM 236

Query: 248 KVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLR 307
           ++ GT   Y  + +       ++   L Q  +  + N     N     P A+DLL+K+L 
Sbjct: 237 RLTGTPPAY-LINRMPSHEARNYIQSLTQMPKMNFANVFIGAN-----PLAVDLLEKMLV 290

Query: 308 YDHQQRLTAKEAMEHPYFYPVVKEQSQPCAD 338
            D  +R+TA +A+ H YF        +P AD
Sbjct: 291 LDSDKRITAAQALAHAYFAQYHDPDDEPVAD 321


>gi|20128774 mitogen-activated protein kinase 11 [Homo sapiens]
          Length = 364

 Score =  140 bits (352), Expect = 2e-33
 Identities = 101/342 (29%), Positives = 174/342 (50%), Gaps = 55/342 (16%)

Query: 24  YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP-----VKKKK 78
           ++  E +   W      Q +R +G G Y  V  A +    ++V VK L       +  ++
Sbjct: 8   FYRQELNKTVWEVPQRLQGLRPVGSGAYGSVCSAYDARLRQKVAVKKLSRPFQSLIHARR 67

Query: 79  IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY------------ 126
             RE+++L++L+   N+I L+D        TPA   E     DF ++Y            
Sbjct: 68  TYRELRLLKHLKH-ENVIGLLDVF------TPATSIE-----DFSEVYLVTTLMGADLNN 115

Query: 127 ----QILTDFDIRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEF 182
               Q L+D  ++F +Y+LL+ L Y HS GI+HRD+KP NV + ++  +LR++D+GLA  
Sbjct: 116 IVKCQALSDEHVQFLVYQLLRGLKYIHSAGIIHRDLKPSNVAV-NEDCELRILDFGLAR- 173

Query: 183 YHPAQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQ 242
               +E    VA+R+++ PE+++++  Y+ ++D+WS+GC++A ++ + +  F G D  DQ
Sbjct: 174 -QADEEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELL-QGKALFPGSDYIDQ 231

Query: 243 LVRIAKVLGTEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVS------P 296
           L RI +V+GT       K            I  +H+R   ++      + L S      P
Sbjct: 232 LKRIMEVVGTPSPEVLAK------------ISSEHARTYIQSLPPMPQKDLSSIFRGANP 279

Query: 297 EALDLLDKLLRYDHQQRLTAKEAMEHPYFYPVVKEQSQPCAD 338
            A+DLL ++L  D  QR++A EA+ H YF      + +P A+
Sbjct: 280 LAIDLLGRMLVLDSDQRVSAAEALAHAYFSQYHDPEDEPEAE 321


>gi|16936528 cyclin-dependent kinase 2 isoform 1 [Homo sapiens]
          Length = 298

 Score =  139 bits (351), Expect = 3e-33
 Identities = 97/305 (31%), Positives = 161/305 (52%), Gaps = 27/305 (8%)

Query: 38  DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLRGG 92
           +++Q V K+G G Y  V++A N    E V +K ++   + +       RE+ +L+ L   
Sbjct: 2   ENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNH- 60

Query: 93  TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI--LTDFD---IRFYMYELLKALDY 147
            NI+KL+D +         LVFE+++  D K+      LT      I+ Y+++LL+ L +
Sbjct: 61  PNIVKLLDVIH--TENKLYLVFEFLHQ-DLKKFMDASALTGIPLPLIKSYLFQLLQGLAF 117

Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVD 206
           CHS  ++HRD+KP N++I+  +  ++L D+GLA  F  P + Y   V + +++ PE+L+ 
Sbjct: 118 CHSHRVLHRDLKPQNLLIN-TEGAIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLG 176

Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT-EELYGYLKKYHID 265
            + Y  ++D+WSLGC+ A M+ RR   F G    DQL RI + LGT +E+         D
Sbjct: 177 CKYYSTAVDIWSLGCIFAEMVTRR-ALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPD 235

Query: 266 LDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325
             P F          +W     S+    +  +   LL ++L YD  +R++AK A+ HP+F
Sbjct: 236 YKPSF---------PKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFF 286

Query: 326 YPVVK 330
             V K
Sbjct: 287 QDVTK 291


>gi|48255970 mitogen-activated protein kinase 12 [Homo sapiens]
          Length = 367

 Score =  139 bits (350), Expect = 4e-33
 Identities = 94/322 (29%), Positives = 178/322 (55%), Gaps = 21/322 (6%)

Query: 24  YWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKIL-KPVKK----KK 78
           ++  E    +W  +  Y+ ++ +G G Y  V  A++     +V +K L +P +     K+
Sbjct: 11  FYRQEVTKTAWEVRAVYRDLQPVGSGAYGAVCSAVDGRTGAKVAIKKLYRPFQSELFAKR 70

Query: 79  IKREVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYIN---NTDFKQL--YQILTDFD 133
             RE+++L+++R   N+I L+D      +      F  +     TD  +L  ++ L +  
Sbjct: 71  AYRELRLLKHMRH-ENVIGLLDVFTPDETLDDFTDFYLVMPFMGTDLGKLMKHEKLGEDR 129

Query: 134 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRV 193
           I+F +Y++LK L Y H+ GI+HRD+KP N+ + ++  +L+++D+GLA       E    V
Sbjct: 130 IQFLVYQMLKGLRYIHAAGIIHRDLKPGNLAV-NEDCELKILDFGLAR--QADSEMTGYV 186

Query: 194 ASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTE 253
            +R+++ PE+++++  Y  ++D+WS+GC++A MI   +  F G D+ DQL  I KV GT 
Sbjct: 187 VTRWYRAPEVILNWMRYTQTVDIWSVGCIMAEMI-TGKTLFKGSDHLDQLKEIMKVTGTP 245

Query: 254 ELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQR 313
               ++++   D   ++   L +  +K + + + +      SP A++LL+K+L  D +QR
Sbjct: 246 PA-EFVQRLQSDEAKNYMKGLPELEKKDFASILTN-----ASPLAVNLLEKMLVLDAEQR 299

Query: 314 LTAKEAMEHPYFYPVVKEQSQP 335
           +TA EA+ HPYF  +   + +P
Sbjct: 300 VTAGEALAHPYFESLHDTEDEP 321


>gi|4826675 cyclin-dependent kinase 5 [Homo sapiens]
          Length = 292

 Score =  139 bits (350), Expect = 4e-33
 Identities = 95/297 (31%), Positives = 157/297 (52%), Gaps = 25/297 (8%)

Query: 40  YQLVRKLGRGKYSEVFEAINITNNERVVVKILK-----PVKKKKIKREVKILENLRGGTN 94
           Y+ + K+G G Y  VF+A N   +E V +K ++             RE+ +L+ L+   N
Sbjct: 4   YEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRLDDDDEGVPSSALREICLLKELKH-KN 62

Query: 95  IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQILTDFD---IRFYMYELLKALDYCHSK 151
           I++L D +     K   LVFE+ +    K       D D   ++ ++++LLK L +CHS+
Sbjct: 63  IVRLHDVLHS--DKKLTLVFEFCDQDLKKYFDSCNGDLDPEIVKSFLFQLLKGLGFCHSR 120

Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVDYQMY 210
            ++HRD+KP N++I+ +  +L+L D+GLA  F  P + Y+  V + +++ P++L   ++Y
Sbjct: 121 NVLHRDLKPQNLLIN-RNGELKLADFGLARAFGIPVRCYSAEVVTLWYRPPDVLFGAKLY 179

Query: 211 DYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELYGYLKKYHIDLDP 268
             S+DMWS GC+ A +     P F G D  DQL RI ++LG  TEE +  + K      P
Sbjct: 180 STSIDMWSAGCIFAELANAGRPLFPGNDVDDQLKRIFRLLGTPTEEQWPSMTKL-----P 234

Query: 269 HFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325
            +       +     N +   N         DLL  LL+ +  QR++A+EA++HPYF
Sbjct: 235 DYKPYPMYPATTSLVNVVPKLN-----ATGRDLLQNLLKCNPVQRISAEEALQHPYF 286


>gi|7657498 MAPK/MAK/MRK overlapping kinase [Homo sapiens]
          Length = 419

 Score =  135 bits (341), Expect = 4e-32
 Identities = 89/302 (29%), Positives = 151/302 (50%), Gaps = 34/302 (11%)

Query: 39  DYQLVRKLGRGKYSEVFEAINITNNERVVVKILKP----VKKKKIKREVKILENLRGGTN 94
           +Y+ + K+G G +SEV +  ++ +      K +K     +++    RE++ L  L    N
Sbjct: 3   NYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPHPN 62

Query: 95  IIKLIDTVKDPVSKTPALVFEYINNTDFKQLY---QILTDFDIRFYMYELLKALDYCHSK 151
           I+ L + V D  S + AL+ E ++   ++ +      L++  I  YMY+L K+LD+ H  
Sbjct: 63  ILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIHRN 122

Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYD 211
           GI HRDVKP N++I  +Q  L+L D+G     +  Q Y   +++R+++ PE L+    Y 
Sbjct: 123 GIFHRDVKPENILI--KQDVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFYT 180

Query: 212 YSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFN 271
           Y +D+WS GC+    I   +P F G +  DQ+ +I  V+GT                   
Sbjct: 181 YKMDLWSAGCVFYE-IASLQPLFPGVNELDQISKIHDVIGTPA----------------Q 223

Query: 272 DILGQHSRKRWENFIHSENRHL--------VSPEALDLLDKLLRYDHQQRLTAKEAMEHP 323
            IL +  + R  NF     +          +SP+ L LL  ++ YD  +R+ A +A++HP
Sbjct: 224 KILTKFKQSRAMNFDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHP 283

Query: 324 YF 325
           YF
Sbjct: 284 YF 285


>gi|20986531 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  134 bits (337), Expect = 1e-31
 Identities = 95/318 (29%), Positives = 166/318 (52%), Gaps = 35/318 (11%)

Query: 40  YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTNI 95
           Y  +  +G G Y  V  A +  N  RV +K + P + +    +  RE+KIL   R   NI
Sbjct: 25  YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENI 83

Query: 96  IKLIDTVKDPVSKTPALVF--EYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHSK 151
           I + D ++ P  +    V+  + +  TD  +L   Q L++  I +++Y++L+ L Y HS 
Sbjct: 84  IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSA 143

Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN----VRVASRYFKGPELLVDY 207
            ++HRD+KP N++++     L++ D+GLA    P  ++       VA+R+++ PE++++ 
Sbjct: 144 NVLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNS 202

Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT---EELYGYL----K 260
           + Y  S+D+WS+GC+LA M+  R P F G+   DQL  I  +LG+   E+L   +    +
Sbjct: 203 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKAR 261

Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320
            Y + L PH N +        W     +        +ALDLLDK+L ++  +R+  ++A+
Sbjct: 262 NYLLSL-PHKNKV-------PWNRLFPN-----ADSKALDLLDKMLTFNPHKRIEVEQAL 308

Query: 321 EHPYFYPVVKEQSQPCAD 338
            HPY         +P A+
Sbjct: 309 AHPYLEQYYDPSDEPIAE 326


>gi|66932916 mitogen-activated protein kinase 1 [Homo sapiens]
          Length = 360

 Score =  134 bits (337), Expect = 1e-31
 Identities = 95/318 (29%), Positives = 166/318 (52%), Gaps = 35/318 (11%)

Query: 40  YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTNI 95
           Y  +  +G G Y  V  A +  N  RV +K + P + +    +  RE+KIL   R   NI
Sbjct: 25  YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENI 83

Query: 96  IKLIDTVKDPVSKTPALVF--EYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHSK 151
           I + D ++ P  +    V+  + +  TD  +L   Q L++  I +++Y++L+ L Y HS 
Sbjct: 84  IGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSA 143

Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN----VRVASRYFKGPELLVDY 207
            ++HRD+KP N++++     L++ D+GLA    P  ++       VA+R+++ PE++++ 
Sbjct: 144 NVLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNS 202

Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT---EELYGYL----K 260
           + Y  S+D+WS+GC+LA M+  R P F G+   DQL  I  +LG+   E+L   +    +
Sbjct: 203 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKAR 261

Query: 261 KYHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAM 320
            Y + L PH N +        W     +        +ALDLLDK+L ++  +R+  ++A+
Sbjct: 262 NYLLSL-PHKNKV-------PWNRLFPN-----ADSKALDLLDKMLTFNPHKRIEVEQAL 308

Query: 321 EHPYFYPVVKEQSQPCAD 338
            HPY         +P A+
Sbjct: 309 AHPYLEQYYDPSDEPIAE 326


>gi|4502709 cell division cycle 2 isoform 1 [Homo sapiens]
          Length = 297

 Score =  134 bits (336), Expect = 2e-31
 Identities = 86/301 (28%), Positives = 160/301 (53%), Gaps = 28/301 (9%)

Query: 38  DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLRGG 92
           +DY  + K+G G Y  V++  + T  + V +K ++   +++       RE+ +L+ LR  
Sbjct: 2   EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60

Query: 93  TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY------QILTDFDIRFYMYELLKALD 146
            NI+ L D +         L+FE+++  D K+        Q +    ++ Y+Y++L+ + 
Sbjct: 61  PNIVSLQDVLMQ--DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117

Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLV 205
           +CHS+ ++HRD+KP N++ID  +  ++L D+GLA  F  P + Y   V + +++ PE+L+
Sbjct: 118 FCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLL 176

Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265
               Y   +D+WS+G + A +   ++P FHG    DQL RI + LGT          + +
Sbjct: 177 GSARYSTPVDIWSIGTIFAELA-TKKPLFHGDSEIDQLFRIFRALGTP---------NNE 226

Query: 266 LDPHFNDILG-QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324
           + P    +   +++  +W+    + +   +    LDLL K+L YD  +R++ K A+ HPY
Sbjct: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286

Query: 325 F 325
           F
Sbjct: 287 F 287


>gi|4502743 cyclin-dependent kinase 7 [Homo sapiens]
          Length = 346

 Score =  132 bits (332), Expect = 5e-31
 Identities = 93/302 (30%), Positives = 161/302 (53%), Gaps = 34/302 (11%)

Query: 40  YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK--------REVKILENLRG 91
           Y+ +  LG G+++ V++A +   N+ V +K +K   + + K        RE+K+L+ L  
Sbjct: 12  YEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQEL-S 70

Query: 92  GTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKALDY 147
             NII L+D          +LVF+++  TD + + +    +LT   I+ YM   L+ L+Y
Sbjct: 71  HPNIIGLLDAFGH--KSNISLVFDFME-TDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEY 127

Query: 148 CHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLVD 206
            H   I+HRD+KP+N+++D +   L+L D+GLA+ F  P + Y  +V +R+++ PELL  
Sbjct: 128 LHQHWILHRDLKPNNLLLD-ENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFG 186

Query: 207 YQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDL 266
            +MY   +DMW++GC+LA ++  R PF  G  + DQL RI + LGT              
Sbjct: 187 ARMYGVGVDMWAVGCILAELLL-RVPFLPGDSDLDQLTRIFETLGT------------PT 233

Query: 267 DPHFNDILGQHSRKRWENFIHSENRHLVS---PEALDLLDKLLRYDHQQRLTAKEAMEHP 323
           +  + D+        +++F      H+ S    + LDL+  L  ++   R+TA +A++  
Sbjct: 234 EEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMK 293

Query: 324 YF 325
           YF
Sbjct: 294 YF 295


>gi|195927041 cell division cycle 2 isoform 3 [Homo sapiens]
          Length = 297

 Score =  132 bits (331), Expect = 6e-31
 Identities = 85/301 (28%), Positives = 159/301 (52%), Gaps = 28/301 (9%)

Query: 38  DDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKK-----IKREVKILENLRGG 92
           +DY  + K+G G Y  V++  + T  + V +K ++   +++       RE+ +L+ LR  
Sbjct: 2   EDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH- 60

Query: 93  TNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLY------QILTDFDIRFYMYELLKALD 146
            NI+ L D +         L+FE+++  D K+        Q +    ++ Y+Y++L+ + 
Sbjct: 61  PNIVSLQDVLMQ--DSRLYLIFEFLS-MDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIV 117

Query: 147 YCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAE-FYHPAQEYNVRVASRYFKGPELLV 205
           +CHS+ ++HRD+KP N++ID  +  ++L D+GLA  F  P + Y     + +++ PE+L+
Sbjct: 118 FCHSRRVLHRDLKPQNLLID-DKGTIKLADFGLARAFGIPIRVYTHEAITLWYRSPEVLL 176

Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHID 265
               Y   +D+WS+G + A +   ++P FHG    DQL RI + LGT          + +
Sbjct: 177 GSARYSTPVDIWSIGTIFAELA-TKKPLFHGDSEIDQLFRIFRALGTP---------NNE 226

Query: 266 LDPHFNDILG-QHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324
           + P    +   +++  +W+    + +   +    LDLL K+L YD  +R++ K A+ HPY
Sbjct: 227 VWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPY 286

Query: 325 F 325
           F
Sbjct: 287 F 287


>gi|225903437 glycogen synthase kinase 3 beta isoform 2 [Homo
           sapiens]
          Length = 420

 Score =  131 bits (330), Expect = 8e-31
 Identities = 96/308 (31%), Positives = 151/308 (49%), Gaps = 29/308 (9%)

Query: 32  PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-REVKILENLR 90
           P    +  Y   + +G G +  V++A    + E V +K  K ++ K+ K RE++I+  L 
Sbjct: 48  PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKL- 104

Query: 91  GGTNIIKL------IDTVKDPVSKTPALVFEYINNTDFK------QLYQILTDFDIRFYM 138
              NI++L          KD V     LV +Y+  T ++      +  Q L    ++ YM
Sbjct: 105 DHCNIVRLRYFFYSSGEKKDEVYLN--LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162

Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYF 198
           Y+L ++L Y HS GI HRD+KP N+++D     L+L D+G A+     +     + SRY+
Sbjct: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222

Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGY 258
           + PEL+     Y  S+D+WS GC+LA ++   +P F G    DQLV I KVLGT      
Sbjct: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP----- 276

Query: 259 LKKYHIDLDPHFNDI-LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAK 317
            ++   +++P++ +    Q     W        R    PEA+ L  +LL Y    RLT  
Sbjct: 277 TREQIREMNPNYTEFKFPQIKAHPWTKVF----RPRTPPEAIALCSRLLEYTPTARLTPL 332

Query: 318 EAMEHPYF 325
           EA  H +F
Sbjct: 333 EACAHSFF 340


>gi|49574532 glycogen synthase kinase 3 alpha [Homo sapiens]
          Length = 483

 Score =  130 bits (328), Expect = 1e-30
 Identities = 93/310 (30%), Positives = 149/310 (48%), Gaps = 33/310 (10%)

Query: 32  PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-REVKILENLR 90
           P    +  Y  ++ +G G +  V++A      E V +K  K ++ K+ K RE++I+  L 
Sbjct: 111 PERSQEVAYTDIKVIGNGSFGVVYQARLAETRELVAIK--KVLQDKRFKNRELQIMRKL- 167

Query: 91  GGTNIIKLIDTVKDPVSKTPAL----VFEYINNTDFKQLYQILTDFD----------IRF 136
              NI++L         K   L    V EY+  T    +Y++   F           ++ 
Sbjct: 168 DHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPET----VYRVARHFTKAKLTIPILYVKV 223

Query: 137 YMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASR 196
           YMY+L ++L Y HS+G+ HRD+KP N+++D     L+L D+G A+     +     + SR
Sbjct: 224 YMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSR 283

Query: 197 YFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELY 256
           Y++ PEL+     Y  S+D+WS GC+LA ++   +P F G    DQLV I KVLGT    
Sbjct: 284 YYRAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTP--- 339

Query: 257 GYLKKYHIDLDPHFNDI-LGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLT 315
              ++   +++P++ +    Q     W     S       PEA+ L   LL Y    RL+
Sbjct: 340 --TREQIREMNPNYTEFKFPQIKAHPWTKVFKSR----TPPEAIALCSSLLEYTPSSRLS 393

Query: 316 AKEAMEHPYF 325
             EA  H +F
Sbjct: 394 PLEACAHSFF 403


>gi|95147356 mitogen-activated protein kinase 15 [Homo sapiens]
          Length = 544

 Score =  130 bits (327), Expect = 2e-30
 Identities = 95/302 (31%), Positives = 152/302 (50%), Gaps = 28/302 (9%)

Query: 40  YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-----REVKILENLRGGTN 94
           Y L R+LG+G Y  V++A++    E V +K +    + K       RE+ +L+      N
Sbjct: 13  YLLRRQLGQGAYGIVWKAVDRRTGEVVAIKKIFDAFRDKTDAQRTFREITLLQEFGDHPN 72

Query: 95  IIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ---ILTDFDIRFYMYELLKALDYCHSK 151
           II L+D ++    +   LVFE+++ TD   + +   +L D  +R   Y+LL+A  + HS 
Sbjct: 73  IISLLDVIRAENDRDIYLVFEFMD-TDLNAVIRKGGLLQDVHVRSIFYQLLRATRFLHSG 131

Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQE------YNVRVASRYFKGPELLV 205
            ++HRD KP NV++D     ++L D+GLA       E          VA+R+++ PE+L+
Sbjct: 132 HVVHRDQKPSNVLLD-ANCTVKLCDFGLARSLGDLPEGPEDQAVTEYVATRWYRAPEVLL 190

Query: 206 DYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVL---GTEELYGYLKKY 262
               Y   +DMWSLGC+L  M+ R  P F G     QL  I + +     E+L       
Sbjct: 191 SSHRYTLGVDMWSLGCILGEML-RGRPLFPGTSTLHQLELILETIPPPSEEDLLALGSGC 249

Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322
              +       LG   R+  +  +  +     SPEALDLL +LL +   +RL+A +A++H
Sbjct: 250 RASVLHQ----LGSRPRQTLDALLPPD----TSPEALDLLRRLLVFAPDKRLSATQALQH 301

Query: 323 PY 324
           PY
Sbjct: 302 PY 303


>gi|89903018 cell cycle related kinase isoform 3 [Homo sapiens]
          Length = 346

 Score =  130 bits (327), Expect = 2e-30
 Identities = 86/299 (28%), Positives = 157/299 (52%), Gaps = 21/299 (7%)

Query: 38  DDYQLVRKLGRGKYSEVFEAINITNNE-----RVVVKILKPVKKKKIKREVKILENLRGG 92
           D Y ++ ++G G +  VF+A ++   E     +V ++ L+     +  RE+K L+ +   
Sbjct: 2   DQYCILGRIGEGAHGIVFKAKHVETGEIVALKKVALRRLEDGFPNQALREIKALQEMEDN 61

Query: 93  TNIIKLIDTVKDPVSKTPALVFEYINNT---DFKQLYQILTDFDIRFYMYELLKALDYCH 149
             +++L      P      L FE++ +      +   + L    ++ Y+  LLK + +CH
Sbjct: 62  QYVVQLKAVF--PHGGGFVLAFEFMLSDLAEVVRHAQRPLAQAQVKSYLQMLLKGVAFCH 119

Query: 150 SKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHP--AQEYNVRVASRYFKGPELLVDY 207
           +  I+HRD+KP N++I     +L++ D+GLA  + P  ++ Y  +VA+R+++ PELL   
Sbjct: 120 ANNIVHRDLKPANLLIS-ASGQLKIADFGLARVFSPDGSRLYTHQVATRWYRAPELLYGA 178

Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLD 267
           + YD  +D+WS+GC++  ++    P F G+++ +QL  + ++LGT     + +   +   
Sbjct: 179 RQYDQGVDLWSVGCIMGELL-NGSPLFPGKNDIEQLCYVLRILGTPNPQVWPELTEL--- 234

Query: 268 PHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPYFY 326
           P +N I    S K        E    VSP+ALDLL + L Y   QR+ A +A+ H YF+
Sbjct: 235 PDYNKI----SFKEQVPMPLEEVLPDVSPQALDLLGQFLLYPPHQRIAASKALLHQYFF 289


>gi|6912584 PFTAIRE protein kinase 1 [Homo sapiens]
          Length = 451

 Score =  130 bits (326), Expect = 2e-30
 Identities = 95/304 (31%), Positives = 158/304 (51%), Gaps = 21/304 (6%)

Query: 32  PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILE 87
           P +G  D Y+ + KLG G Y+ V++  +  N + V +K+++  +++       RE  +L+
Sbjct: 109 PKFGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLK 168

Query: 88  NLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFDIRFYMYELLK 143
            L+   NI+ L D +     +T  LVFEY++ TD  Q        L   +++ ++++LL+
Sbjct: 169 GLKHA-NIVLLHDIIH--TKETLTLVFEYVH-TDLCQYMDKHPGGLHPDNVKLFLFQLLR 224

Query: 144 ALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPE 202
            L Y H + I+HRD+KP N++I     +L+L D+GLA     P+  Y+  V + +++ P+
Sbjct: 225 GLSYIHQRYILHRDLKPQNLLIS-DTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPD 283

Query: 203 LLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKY 262
           +L+    Y   LDMW +GC+   MI     F   +D  DQL RI  VLGT     +   +
Sbjct: 284 VLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVH 343

Query: 263 HIDLDPHFN-DILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321
            +   PHF  +    +S K   N   + N+      A DL  KLL+   + RL+A+ A+ 
Sbjct: 344 SL---PHFKPERFTLYSSK---NLRQAWNKLSYVNHAEDLASKLLQCSPKNRLSAQAALS 397

Query: 322 HPYF 325
           H YF
Sbjct: 398 HEYF 401


>gi|37595545 PCTAIRE protein kinase 2 [Homo sapiens]
          Length = 523

 Score =  129 bits (324), Expect = 4e-30
 Identities = 87/303 (28%), Positives = 165/303 (54%), Gaps = 26/303 (8%)

Query: 34  WGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILENL 89
           +G  + Y  + KLG G Y+ V++  +      V +K ++   ++       REV +L++L
Sbjct: 186 FGKMETYIKLEKLGEGTYATVYKGRSKLTENLVALKEIRLEHEEGAPCTAIREVSLLKDL 245

Query: 90  RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKAL 145
           +   NI+ L D V    S T  LVFEY++  D KQ       I++  +++ ++Y++L+ L
Sbjct: 246 KHA-NIVTLHDIVHTDKSLT--LVFEYLDK-DLKQYMDDCGNIMSMHNVKLFLYQILRGL 301

Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELL 204
            YCH + ++HRD+KP N++I +++ +L+L D+GLA     P + Y+  V + +++ P++L
Sbjct: 302 AYCHRRKVLHRDLKPQNLLI-NEKGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVL 360

Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT--EELYGYLKKY 262
           +    Y   +DMW +GC+   M   R P F G    D+L  I ++LGT  +E +  +   
Sbjct: 361 LGSSEYSTQIDMWGVGCIFFEMASGR-PLFPGSTVEDELHLIFRLLGTPSQETWPGISS- 418

Query: 263 HIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEH 322
                   N+    ++  +++      +   +  E ++L+ K L+Y+ ++R++A+EAM+H
Sbjct: 419 --------NEEFKNYNFPKYKPQPLINHAPRLDSEGIELITKFLQYESKKRVSAEEAMKH 470

Query: 323 PYF 325
            YF
Sbjct: 471 VYF 473


>gi|21361340 glycogen synthase kinase 3 beta isoform 1 [Homo
           sapiens]
          Length = 433

 Score =  128 bits (322), Expect = 7e-30
 Identities = 102/317 (32%), Positives = 151/317 (47%), Gaps = 34/317 (10%)

Query: 32  PSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK-REVKILENLR 90
           P    +  Y   + +G G +  V++A    + E V +K  K ++ K+ K RE++I+  L 
Sbjct: 48  PDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIK--KVLQDKRFKNRELQIMRKL- 104

Query: 91  GGTNIIKL------IDTVKDPVSKTPALVFEYINNTDFK------QLYQILTDFDIRFYM 138
              NI++L          KD V     LV +Y+  T ++      +  Q L    ++ YM
Sbjct: 105 DHCNIVRLRYFFYSSGEKKDEVYLN--LVLDYVPETVYRVARHYSRAKQTLPVIYVKLYM 162

Query: 139 YELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYF 198
           Y+L ++L Y HS GI HRD+KP N+++D     L+L D+G A+     +     + SRY+
Sbjct: 163 YQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYY 222

Query: 199 KGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT---EEL 255
           + PEL+     Y  S+D+WS GC+LA ++   +P F G    DQLV I KVLGT   E++
Sbjct: 223 RAPELIFGATDYTSSIDVWSAGCVLAELLL-GQPIFPGDSGVDQLVEIIKVLGTPTREQI 281

Query: 256 ------YGYLKKYHIDLDPHFNDILGQ-HSRKRWENFIHSENRHLVSPEALDLLDKLLRY 308
                 Y   K   I   P   D  G  H       F     R    PEA+ L  +LL Y
Sbjct: 282 REMNPNYTEFKFPQIKAHPWTKDSSGTGHFTSGVRVF-----RPRTPPEAIALCSRLLEY 336

Query: 309 DHQQRLTAKEAMEHPYF 325
               RLT  EA  H +F
Sbjct: 337 TPTARLTPLEACAHSFF 353


>gi|91718899 mitogen-activated protein kinase 3 isoform 1 [Homo
           sapiens]
          Length = 379

 Score =  128 bits (322), Expect = 7e-30
 Identities = 89/314 (28%), Positives = 163/314 (51%), Gaps = 27/314 (8%)

Query: 40  YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKK----KIKREVKILENLRGGTNI 95
           Y  ++ +G G Y  V  A +     RV +K + P + +    +  RE++IL   R   N+
Sbjct: 42  YTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRH-ENV 100

Query: 96  IKLIDTVKDPVSKTPALVF--EYINNTDFKQLY--QILTDFDIRFYMYELLKALDYCHSK 151
           I + D ++    +    V+  + +  TD  +L   Q L++  I +++Y++L+ L Y HS 
Sbjct: 101 IGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSA 160

Query: 152 GIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYN----VRVASRYFKGPELLVDY 207
            ++HRD+KP N++I+     L++ D+GLA    P  ++       VA+R+++ PE++++ 
Sbjct: 161 NVLHRDLKPSNLLIN-TTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNS 219

Query: 208 QMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGT---EELYGYLKKYHI 264
           + Y  S+D+WS+GC+LA M+  R P F G+   DQL  I  +LG+   E+L   +     
Sbjct: 220 KGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLNCIINM--- 275

Query: 265 DLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAMEHPY 324
               ++   L   ++  W       +      +ALDLLD++L ++  +R+T +EA+ HPY
Sbjct: 276 -KARNYLQSLPSKTKVAWAKLFPKSD-----SKALDLLDRMLTFNPNKRITVEEALAHPY 329

Query: 325 FYPVVKEQSQPCAD 338
                    +P A+
Sbjct: 330 LEQYYDPTDEPVAE 343


>gi|21040235 PFTAIRE protein kinase 2 [Homo sapiens]
          Length = 384

 Score =  128 bits (322), Expect = 7e-30
 Identities = 97/322 (30%), Positives = 167/322 (51%), Gaps = 38/322 (11%)

Query: 22  REYWDYEAHVPSWGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK- 80
           R+ + +   +P +G    Y  + KLG G Y+ V++ I+  N + V +K++    ++ +  
Sbjct: 35  RQGFQWRKSLP-FGAASSYLNLEKLGEGSYATVYKGISRINGQLVALKVISMNAEEGVPF 93

Query: 81  ---REVKILENLRGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQI----LTDFD 133
              RE  +L+ L+   NI+ L D +     +T   VFEY++ TD  Q        L   +
Sbjct: 94  TAIREASLLKGLKHA-NIVLLHDIIH--TKETLTFVFEYMH-TDLAQYMSQHPGGLHPHN 149

Query: 134 IRFYMYELLKALDYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVR 192
           +R +M++LL+ L Y H + ++HRD+KP N++I H   +L+L D+GLA     P+Q Y+  
Sbjct: 150 VRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISH-LGELKLADFGLARAKSIPSQTYSSE 208

Query: 193 VASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDN-YDQLVRIAKVLG 251
           V + +++ P+ L+    Y   LD+W  GC+   M F+ +P F G  N  +QL +I +VLG
Sbjct: 209 VVTLWYRPPDALLGATEYSSELDIWGAGCIFIEM-FQGQPLFPGVSNILEQLEKIWEVLG 267

Query: 252 --TEELYGYLKKYHIDLDPHFNDILGQHSRKRWENFIHSENRHLV------SPEALDLLD 303
             TE+ +  + K      P++N          W       + H+V       PEA DL  
Sbjct: 268 VPTEDTWPGVSKL-----PNYN--------PEWFPLPTPRSLHVVWNRLGRVPEAEDLAS 314

Query: 304 KLLRYDHQQRLTAKEAMEHPYF 325
           ++L+   + R++A+EA+ H YF
Sbjct: 315 QMLKGFPRDRVSAQEALVHDYF 336


>gi|197333744 PCTAIRE protein kinase 1 isoform 2 [Homo sapiens]
          Length = 502

 Score =  127 bits (319), Expect = 1e-29
 Identities = 89/304 (29%), Positives = 165/304 (54%), Gaps = 28/304 (9%)

Query: 34  WGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILENL 89
           +G  + Y  + KLG G Y+ V++  +   +  V +K ++   ++       REV +L++L
Sbjct: 165 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 224

Query: 90  RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKAL 145
           +   NI+ L D +    S T  LVFEY++  D KQ       I+   +++ ++++LL+ L
Sbjct: 225 KHA-NIVTLHDIIHTEKSLT--LVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGL 280

Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELL 204
            YCH + ++HRD+KP N++I +++ +L+L D+GLA     P + Y+  V + +++ P++L
Sbjct: 281 AYCHRQKVLHRDLKPQNLLI-NERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL 339

Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELY-GYLKK 261
           +    Y   +DMW +GC+   M   R P F G    +QL  I ++LG  TEE + G L  
Sbjct: 340 LGSTDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILS- 397

Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321
                    N+    ++  ++       +   +  +  DLL KLL+++ + R++A++AM+
Sbjct: 398 ---------NEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMK 448

Query: 322 HPYF 325
           HP+F
Sbjct: 449 HPFF 452


>gi|5453860 PCTAIRE protein kinase 1 isoform 1 [Homo sapiens]
          Length = 496

 Score =  127 bits (319), Expect = 1e-29
 Identities = 89/304 (29%), Positives = 165/304 (54%), Gaps = 28/304 (9%)

Query: 34  WGNQDDYQLVRKLGRGKYSEVFEAINITNNERVVVKILKPVKKKKIK----REVKILENL 89
           +G  + Y  + KLG G Y+ V++  +   +  V +K ++   ++       REV +L++L
Sbjct: 159 FGKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALKEIRLEHEEGAPCTAIREVSLLKDL 218

Query: 90  RGGTNIIKLIDTVKDPVSKTPALVFEYINNTDFKQLYQ----ILTDFDIRFYMYELLKAL 145
           +   NI+ L D +    S T  LVFEY++  D KQ       I+   +++ ++++LL+ L
Sbjct: 219 KHA-NIVTLHDIIHTEKSLT--LVFEYLDK-DLKQYLDDCGNIINMHNVKLFLFQLLRGL 274

Query: 146 DYCHSKGIMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYH-PAQEYNVRVASRYFKGPELL 204
            YCH + ++HRD+KP N++I +++ +L+L D+GLA     P + Y+  V + +++ P++L
Sbjct: 275 AYCHRQKVLHRDLKPQNLLI-NERGELKLADFGLARAKSIPTKTYSNEVVTLWYRPPDIL 333

Query: 205 VDYQMYDYSLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLG--TEELY-GYLKK 261
           +    Y   +DMW +GC+   M   R P F G    +QL  I ++LG  TEE + G L  
Sbjct: 334 LGSTDYSTQIDMWGVGCIFYEMATGR-PLFPGSTVEEQLHFIFRILGTPTEETWPGILS- 391

Query: 262 YHIDLDPHFNDILGQHSRKRWENFIHSENRHLVSPEALDLLDKLLRYDHQQRLTAKEAME 321
                    N+    ++  ++       +   +  +  DLL KLL+++ + R++A++AM+
Sbjct: 392 ---------NEEFKTYNYPKYRAEALLSHAPRLDSDGADLLTKLLQFEGRNRISAEDAMK 442

Query: 322 HPYF 325
           HP+F
Sbjct: 443 HPFF 446


>gi|27477122 intestinal cell kinase [Homo sapiens]
          Length = 632

 Score =  127 bits (318), Expect = 2e-29
 Identities = 82/296 (27%), Positives = 154/296 (52%), Gaps = 25/296 (8%)

Query: 40  YQLVRKLGRGKYSEVFEAINITNNERVVVKILKPV----KKKKIKREVKILENLRGGTNI 95
           Y  +R+LG G Y  V    +I + E + +K +K      ++    REVK L+ L    N+
Sbjct: 4   YTTIRQLGDGTYGSVLLGRSIESGELIAIKKMKRKFYSWEECMNLREVKSLKKLNHA-NV 62

Query: 96  IKLIDTVKDPVSKTPALVFEYINNTDF---KQLYQILTDFDIRFYMYELLKALDYCHSKG 152
           +KL + +++  +     +FEY+    +   K+  ++  +  IR  MY++L+ L + H  G
Sbjct: 63  VKLKEVIRE--NDHLYFIFEYMKENLYQLIKERNKLFPESAIRNIMYQILQGLAFIHKHG 120

Query: 153 IMHRDVKPHNVMIDHQQKKLRLIDWGLAEFYHPAQEYNVRVASRYFKGPELLVDYQMYDY 212
             HRD+KP N++    +  +++ D+GLA        Y   V++R+++ PE+L+    Y  
Sbjct: 121 FFHRDLKPENLLCMGPEL-VKIADFGLAREIRSKPPYTDYVSTRWYRAPEVLLRSTNYSS 179

Query: 213 SLDMWSLGCMLASMIFRREPFFHGQDNYDQLVRIAKVLGTEELYGYLKKYHIDLDPHFND 272
            +D+W++GC++A  ++   P F G    D + +I +VLGT +   + + Y +    +F  
Sbjct: 180 PIDVWAVGCIMAE-VYTLRPLFPGASEIDTIFKICQVLGTPKKTDWPEGYQLSSAMNF-- 236

Query: 273 ILGQHSRKRWENFIHSENRHLV---SPEALDLLDKLLRYDHQQRLTAKEAMEHPYF 325
                   RW   + +  + L+   S EA+ LL  +L++D ++R TA +A+ +PYF
Sbjct: 237 --------RWPQCVPNNLKTLIPNASSEAVQLLRDMLQWDPKKRPTASQALRYPYF 284


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.138    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 13,327,360
Number of Sequences: 37866
Number of extensions: 572496
Number of successful extensions: 3189
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 536
Number of HSP's successfully gapped in prelim test: 192
Number of HSP's that attempted gapping in prelim test: 1401
Number of HSP's gapped (non-prelim): 1008
length of query: 350
length of database: 18,247,518
effective HSP length: 103
effective length of query: 247
effective length of database: 14,347,320
effective search space: 3543788040
effective search space used: 3543788040
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.