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Search of human proteins with 4502805
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502805 chromogranin A precursor [Homo sapiens]
(457 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502805 chromogranin A precursor [Homo sapiens] 903 0.0
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 102 7e-22
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 76 7e-14
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 76 7e-14
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 76 7e-14
gi|221316599 chromogranin B precursor [Homo sapiens] 75 2e-13
gi|148746195 trichohyalin [Homo sapiens] 66 6e-11
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof... 64 4e-10
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof... 62 1e-09
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof... 62 1e-09
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens] 61 2e-09
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens] 61 2e-09
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 61 2e-09
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof... 61 2e-09
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 61 2e-09
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex... 60 3e-09
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 60 3e-09
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 60 5e-09
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 59 7e-09
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre... 59 7e-09
gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f... 59 7e-09
gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b ... 59 7e-09
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 58 2e-08
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 57 3e-08
gi|24415404 MDN1, midasin homolog [Homo sapiens] 57 3e-08
gi|23503317 coiled-coil domain containing 96 [Homo sapiens] 57 3e-08
gi|115648142 centrosomal protein 164kDa [Homo sapiens] 57 5e-08
gi|157738619 smoothelin-like 1 [Homo sapiens] 57 5e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 56 6e-08
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 56 6e-08
>gi|4502805 chromogranin A precursor [Homo sapiens]
Length = 457
Score = 903 bits (2334), Expect = 0.0
Identities = 457/457 (100%), Positives = 457/457 (100%)
Query: 1 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL 60
MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL
Sbjct: 1 MRSAAVLALLLCAGQVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQECFETL 60
Query: 61 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA 120
RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA
Sbjct: 61 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEA 120
Query: 121 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA 180
VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA
Sbjct: 121 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA 180
Query: 181 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG 240
TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG
Sbjct: 181 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG 240
Query: 241 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS 300
EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS
Sbjct: 241 EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHS 300
Query: 301 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG 360
QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG
Sbjct: 301 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG 360
Query: 361 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE 420
QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE
Sbjct: 361 QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE 420
Query: 421 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG 457
EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG
Sbjct: 421 EEGSANRRPEDQELESLSAIEAELEKVAHQLQALRRG 457
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 102 bits (254), Expect = 7e-22
Identities = 109/406 (26%), Positives = 164/406 (40%), Gaps = 45/406 (11%)
Query: 71 RHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVM 130
R Q KE +G +E + ++ G +E E + E +E E ++
Sbjct: 715 REQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGE 774
Query: 131 EKREDSKEAEKSG--EATDGARPQALPEPMQESKAEGN-------NQAPGEEEEEEEEAT 181
K+E+ E+ G E G + E E K EG + GE EEEEEE
Sbjct: 775 RKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGE 834
Query: 182 NTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEE-----EEE 236
++ G + EG+ +G +G E+G E G + + E EEEE EEE
Sbjct: 835 GEEEEGEGEEEEGEGEEEEGEGKGEEEG----EEGEGEEEGEEGEGEGEEEEGEGEGEEE 890
Query: 237 AEA-GEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAG----KPGAEEAQDP 291
E GEE E EG G E +GE + E +G G + G E +D
Sbjct: 891 GEGEGEEEEGEGEG------EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDG 944
Query: 292 EGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKE 351
EG+GE+E + + EEEE G G + GE E EE E E+ + + ++ +E
Sbjct: 945 EGEGEEEEGEWEGEEEE------GEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEE 998
Query: 352 LTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQV 411
E+ EG+EE E + + G G G E E G +
Sbjct: 999 --GEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKE-GEGEEN 1055
Query: 412 RGYPEEKKEEEG-------SANRRPEDQELESLSAIEAELEKVAHQ 450
R EE++EEEG N R + +E + +S I+ ++ H+
Sbjct: 1056 RRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHK 1101
Score = 80.9 bits (198), Expect = 2e-15
Identities = 88/356 (24%), Positives = 136/356 (38%), Gaps = 26/356 (7%)
Query: 100 FEDELSEVLENQSSQAELK---EAVEEPSSKDVMEKREDSKEAEKSGE-ATDGARPQALP 155
++DE E E + E++ E +E + K+ +KR+ ++ +K E R Q +
Sbjct: 669 WQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEME 728
Query: 156 EPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREK 215
E +E EG + EEEEE+E ++ G + EG+ E E+
Sbjct: 729 EGGEEEHGEGEEEEGDREEEEEKEGEG--------KEEGEGEEVEGEREKEEGERKKEER 780
Query: 216 GLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEAL 275
E G + + E EEEE GEE EE G G +E + E E
Sbjct: 781 AGKEEKGEEEGDQGEGEEEETEGRGEE--KEEGGEVEGGEVEEGKGEREEEEEEGEGEEE 838
Query: 276 AVDGAGKPGAEEAQDPEGKGEQ-----EHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEE 330
+G + G E ++ EGKGE+ E ++ EE E +G G + GE E EEE
Sbjct: 839 EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898
Query: 331 RLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQL 390
E E+ ++ E +G+EE E+ + G G +
Sbjct: 899 EGEGEGEEEGEGEGEEE-------EGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEE 951
Query: 391 RRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEK 446
W E E + G E + EE E++E E E E E+
Sbjct: 952 EGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEE 1007
Score = 76.6 bits (187), Expect = 4e-14
Identities = 102/383 (26%), Positives = 149/383 (38%), Gaps = 62/383 (16%)
Query: 80 QDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEA 139
+++ + KE A K + E E+ EN KE E S D+ +K E S+
Sbjct: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSD-DLTDKAEVSEGK 640
Query: 140 EKS-GEATDGARPQA-----------------LPEPMQESKAEGNNQAPGEEEE---EEE 178
KS GEA DG + E ++ K G + PGE E+ E+E
Sbjct: 641 AKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
Query: 179 EATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAE 238
E ++ G Q E + E G + E G G + + + EEEEE+E E
Sbjct: 701 EWKKRDGEEQEQKEREQGHQKERNQEMEEGG--EEEHG----EGEEEEGDREEEEEKEGE 754
Query: 239 AGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQE 298
EE EE G +E +GE + E + AGK E + +G+GE+E
Sbjct: 755 GKEEGEGEEVE-----------GEREKEEGERKKE----ERAGKEEKGEEEGDQGEGEEE 799
Query: 299 HSQQK-EEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKR 357
++ + EE+EE V G GK GE E+EEE E E+ + E+
Sbjct: 800 ETEGRGEEKEEGGEVEGGEVEEGK-GEREEEEEEGEGEEEEGE------------GEEEE 846
Query: 358 LEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEE 417
EG+EEE + + G G G E+ G + G EE
Sbjct: 847 GEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEE 906
Query: 418 K-----KEEEGSANRRPEDQELE 435
+ +EEEG E +E E
Sbjct: 907 EGEGEGEEEEGEGKGEEEGEEGE 929
Score = 50.8 bits (120), Expect = 2e-06
Identities = 78/337 (23%), Positives = 126/337 (37%), Gaps = 32/337 (9%)
Query: 108 LENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNN 167
++N S+ L E + + +M + K + S + Q + E Q++ N+
Sbjct: 484 IDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLS-PVQKQKKQQTIGELTQDTALTEND 542
Query: 168 QAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKR 227
+ +E EE E SQ Q E S D E + E
Sbjct: 543 DS--DEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFS----DEEVEIPEEKEGAEDS 596
Query: 228 EEEEEEEEEAEAGEEAVPEEEG---PTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPG 284
+ EE+E EA EE V G T +L+ + E+ +G+++S A DG G
Sbjct: 597 KGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLT-DKAEVSEGKAKSVGEAEDGP--EG 653
Query: 285 AEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFR--GGKSGELEQEEERLSKEWEDSKR- 341
+ EG EH Q +E E+ +G G EL ++EE ++ E+ ++
Sbjct: 654 RGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQK 713
Query: 342 ------WSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWR 395
+ +Q +E E+ EG+EEE D + K G G + G
Sbjct: 714 EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEK----------EGEGKEEGEGEE 763
Query: 396 PSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQ 432
+ E + R EEK EEEG E++
Sbjct: 764 VEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEE 800
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 75.9 bits (185), Expect = 7e-14
Identities = 97/403 (24%), Positives = 163/403 (40%), Gaps = 60/403 (14%)
Query: 84 LQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSG 143
+Q K A + K F +E+ E + + ++E++EA+ + + + +E+ KEA +
Sbjct: 436 IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK 495
Query: 144 EATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPP----ASLPSQKYPGPQA 199
E A + + KA E E+EEEE A + G +
Sbjct: 496 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 555
Query: 200 EGDSEGLSQGLVDREKGLSAEPGWQAKREEE---EEEEEEAEAGEEAVPEE--EGPTVVL 254
EG SE + E AE G +A+ +EE EE+ EE EE V + E P
Sbjct: 556 EGSSEKEEGEQEEGETEAEAE-GEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 614
Query: 255 NPHPSLGYKEIRKGESRSEALAVDGAGK------PGAEEAQDP------EGKGEQEHSQQ 302
+P P +E KG+S V+ GK P E+ + P E KG+ S+
Sbjct: 615 SPVPKSPVEE--KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS 672
Query: 303 KEEEEEMAVVPQGLFRGGKS------GELEQEEERLSKEWEDSKRWSKMDQLAKELTAEK 356
EE+ + VP+ KS GE ++EEE+ KE ++ K ++ K++ +K
Sbjct: 673 PVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK 732
Query: 357 RLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQV----- 411
+ E +EE + + + + +++ E G PLQ
Sbjct: 733 KAESPVKEEAVAEV-----------------VTITKSVKVHLEKETKEEGKPLQQEKEKE 775
Query: 412 ----RGYPEEKKEEEGSANRRPED----QELESLSAIEAELEK 446
G EE+ ++G+ R ED E+E +E E ++
Sbjct: 776 KAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKE 818
Score = 64.3 bits (155), Expect = 2e-10
Identities = 75/319 (23%), Positives = 135/319 (42%), Gaps = 37/319 (11%)
Query: 81 DLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAE 140
D A +G E+ +K G ++E E + +AE KE K V EK E+ E
Sbjct: 546 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE------EKKVEEKSEEVATKE 599
Query: 141 KSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQ-KYPGPQA 199
+ +P+ P+ +S E ++P + EE+ + P + + + K P P++
Sbjct: 600 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 659
Query: 200 EGDSEG---LSQGLVD------------REKGLSAEPGWQAKREEEEEEEEEAEAGEEAV 244
+ +G +S+ V+ E AE G ++EEEE+E +EA E+
Sbjct: 660 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 719
Query: 245 PEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKE 304
+EE P V P + K E+ +E + + + K E+ EGK Q+ ++++
Sbjct: 720 KKEEKPKDV--PEKKKAESPV-KEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 776
Query: 305 EEEEMAVVPQGLFRGGK---------SGELEQEEERLSKEWEDSKRWSKMDQLAKELTAE 355
E +G +G K +GE+E +EE E E ++ S ++ +T
Sbjct: 777 AGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE---VEQETKEKGSGREEEKGVVTNG 833
Query: 356 KRLEGQEEEEDNRDSSMKL 374
L +E++ S K+
Sbjct: 834 LDLSPADEKKGGDKSEEKV 852
Score = 36.6 bits (83), Expect = 0.049
Identities = 92/365 (25%), Positives = 140/365 (38%), Gaps = 48/365 (13%)
Query: 103 ELSEVLENQSSQAELKEAVEEPSSK--DVMEKREDSKEAEKSG-EATDGARPQALPEPMQ 159
E+ LE+ S Q + +A E + + E E +KEA +S E R Q + ++
Sbjct: 272 EIRSQLESHSDQ-NMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSIE 330
Query: 160 ESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLS----------QG 209
G ++ + + EE N L S + Q E + G Q
Sbjct: 331 LESVRGTKESLERQLSDIEERHNH----DLSSYQDTIQQLENELRGTKWEMARHLREYQD 386
Query: 210 LVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGE 269
L++ + L E K E EE AG GP P ++ K I+K +
Sbjct: 387 LLNVKMALDIEIAAYRKLLEGEETRFSTFAGSIT-----GPLYTHRPPITISSK-IQKPK 440
Query: 270 SRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEE----EEEMAVVPQGLFRGGKSGEL 325
+ L V EE + E K E E S+ +E EE+AV + K
Sbjct: 441 VEAPKLKVQ---HKFVEEIIE-ETKVEDEKSEMEEALTAITEELAV---SMKEEKKEAAE 493
Query: 326 EQEEERLSKEWEDSKRWSKMDQLAKELTAEK----RLEGQEEEEDNRDSSMKLSFRARAY 381
E+EEE ++E E + + S + A E+ E+ EGQEEEE+ + + S +A
Sbjct: 494 EKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAK--SDQAEEG 551
Query: 382 GFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIE 441
G G + E EA G E KEE+ + E E L A +
Sbjct: 552 GSEKEGSSEKEEGEQEEGETEAEA------EGEEAEAKEEKKVEEKSEEVATKEELVA-D 604
Query: 442 AELEK 446
A++EK
Sbjct: 605 AKVEK 609
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 75.9 bits (185), Expect = 7e-14
Identities = 97/403 (24%), Positives = 163/403 (40%), Gaps = 60/403 (14%)
Query: 84 LQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSG 143
+Q K A + K F +E+ E + + ++E++EA+ + + + +E+ KEA +
Sbjct: 60 IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK 119
Query: 144 EATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPP----ASLPSQKYPGPQA 199
E A + + KA E E+EEEE A + G +
Sbjct: 120 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 179
Query: 200 EGDSEGLSQGLVDREKGLSAEPGWQAKREEE---EEEEEEAEAGEEAVPEE--EGPTVVL 254
EG SE + E AE G +A+ +EE EE+ EE EE V + E P
Sbjct: 180 EGSSEKEEGEQEEGETEAEAE-GEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAK 238
Query: 255 NPHPSLGYKEIRKGESRSEALAVDGAGK------PGAEEAQDP------EGKGEQEHSQQ 302
+P P +E KG+S V+ GK P E+ + P E KG+ S+
Sbjct: 239 SPVPKSPVEE--KGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKS 296
Query: 303 KEEEEEMAVVPQGLFRGGKS------GELEQEEERLSKEWEDSKRWSKMDQLAKELTAEK 356
EE+ + VP+ KS GE ++EEE+ KE ++ K ++ K++ +K
Sbjct: 297 PVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKK 356
Query: 357 RLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQV----- 411
+ E +EE + + + + +++ E G PLQ
Sbjct: 357 KAESPVKEEAVAEV-----------------VTITKSVKVHLEKETKEEGKPLQQEKEKE 399
Query: 412 ----RGYPEEKKEEEGSANRRPED----QELESLSAIEAELEK 446
G EE+ ++G+ R ED E+E +E E ++
Sbjct: 400 KAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKE 442
Score = 64.3 bits (155), Expect = 2e-10
Identities = 75/319 (23%), Positives = 135/319 (42%), Gaps = 37/319 (11%)
Query: 81 DLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAE 140
D A +G E+ +K G ++E E + +AE KE K V EK E+ E
Sbjct: 170 DQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKE------EKKVEEKSEEVATKE 223
Query: 141 KSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQ-KYPGPQA 199
+ +P+ P+ +S E ++P + EE+ + P + + + K P P++
Sbjct: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 283
Query: 200 EGDSEG---LSQGLVD------------REKGLSAEPGWQAKREEEEEEEEEAEAGEEAV 244
+ +G +S+ V+ E AE G ++EEEE+E +EA E+
Sbjct: 284 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 343
Query: 245 PEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKE 304
+EE P V P + K E+ +E + + + K E+ EGK Q+ ++++
Sbjct: 344 KKEEKPKDV--PEKKKAESPV-KEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEK 400
Query: 305 EEEEMAVVPQGLFRGGK---------SGELEQEEERLSKEWEDSKRWSKMDQLAKELTAE 355
E +G +G K +GE+E +EE E E ++ S ++ +T
Sbjct: 401 AGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEE---VEQETKEKGSGREEEKGVVTNG 457
Query: 356 KRLEGQEEEEDNRDSSMKL 374
L +E++ S K+
Sbjct: 458 LDLSPADEKKGGDKSEEKV 476
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 75.9 bits (185), Expect = 7e-14
Identities = 85/391 (21%), Positives = 156/391 (39%), Gaps = 41/391 (10%)
Query: 85 QGAKERAHQQKKHSGFEDELSEVL----ENQSSQAELKEAVEEPSSKDVMEKREDSKEAE 140
+G ER + SG ED L + Q++ E +E P ++ + + EA
Sbjct: 1795 EGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAP 1854
Query: 141 KSGEATDGARPQALPEP--MQESKAEGNNQAPGEE------------EEEEEEATNTHPP 186
++ A +A PE ++ +AEG Q E+ E E EA
Sbjct: 1855 EAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKE 1914
Query: 187 ASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPE 246
A ++ + EG+ E S+G +E +A+ + + + E E E EA EEA PE
Sbjct: 1915 AQPETESVEALETEGEDEPESEGAEAQEAEEAAQEA-EGQTQPESEVIESQEAEEEAQPE 1973
Query: 247 EEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEE 306
E ++ E E +G +P +E+ + PE +GE + ++++ +
Sbjct: 1974 SE---------------DVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQP 2018
Query: 307 EEMAVVPQGLFRGGKSGELEQEEERLSKEWE---DSKRWSKMDQLAKELTAE-KRLEGQE 362
E V Q G ++ E+E E ++ + + D + ++ A+E E + EG+
Sbjct: 2019 ESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEA 2078
Query: 363 EEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEE 422
E + + A+ P+ + + ++ E Q E E E
Sbjct: 2079 HPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAE 2138
Query: 423 GSANRRPEDQELESLSAIEAELEKVAHQLQA 453
G A +PE + +E+ A E E + + ++A
Sbjct: 2139 GEA--QPESEGVEAQDA-EGEAQPESEGIEA 2166
Score = 65.1 bits (157), Expect = 1e-10
Identities = 62/236 (26%), Positives = 97/236 (41%), Gaps = 21/236 (8%)
Query: 83 ALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELK---EAVEEPSSKDVMEKREDSKEA 139
A + A+E + ++ G SE ++ Q ++ E + E VE P ++ +K E +
Sbjct: 2060 AEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAP 2119
Query: 140 EKSGEATDGAR----PQALPEPMQESKAEGNNQAPGEEEEEEE--EATNTHPPASLPSQK 193
E GEA + P+A E ES+ A GE + E E EA A +
Sbjct: 2120 ETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQPELEG 2179
Query: 194 YPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEE--------EEAEAGEEAVP 245
P+AEG+++ S+G+ E A+P + E EEE E EA EA P
Sbjct: 2180 VEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQP 2239
Query: 246 EEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQ 301
E EG T G ++ G+ +SE + + P P G+ H +
Sbjct: 2240 ESEGET----QGEKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQR 2291
Score = 64.7 bits (156), Expect = 2e-10
Identities = 88/350 (25%), Positives = 144/350 (41%), Gaps = 44/350 (12%)
Query: 87 AKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEAT 146
A+E ++ G SEV+E+Q ++ E +P S+DV + + E GEA
Sbjct: 1940 AQEAEEAAQEAEGQTQPESEVIESQEAEEEA-----QPESEDVEALEVEVETQEAEGEA- 1993
Query: 147 DGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD---S 203
Q E ++ +AEG Q E EEE + + A S+ + EG+ +
Sbjct: 1994 -----QPESEDVEAPEAEGEMQ----EAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKT 2044
Query: 204 EGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEA----------EAGEEAVPEEEG---P 250
EG +Q D + AE Q E +E E EA EA EA PE EG P
Sbjct: 2045 EGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAP 2104
Query: 251 TVVLNPHPSLGYKEIR-KGESRSEALAV-----DGAGKPGAE--EAQDPEGKG--EQEHS 300
+ G + +GE++ E+ + +G +P +E EAQD EG+ E E
Sbjct: 2105 EAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGI 2164
Query: 301 QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQL-AKELTAEKRLE 359
+ +E EEE +G+ GE + E E + + + +++ + A E E + E
Sbjct: 2165 EAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224
Query: 360 GQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPL 409
+ E + + G + PQ+ G E++ E+ P+
Sbjct: 2225 PEGVETPEAEGEAQPESEGETQGEKKGSPQVSLG--DGQSEEASESSSPV 2272
Score = 60.8 bits (146), Expect = 2e-09
Identities = 78/341 (22%), Positives = 127/341 (37%), Gaps = 46/341 (13%)
Query: 143 GEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD 202
GE +G++ + + +AEG+ A E + T+ Q+ G G+
Sbjct: 1743 GEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGE 1802
Query: 203 SEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEA-EAGEEAVPEEEGPTVVLNPHPSLG 261
+ G G D +G +A G Q + + E EA EA EA PE EG
Sbjct: 1803 TGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEG------------ 1850
Query: 262 YKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGK 321
+ E+ +A +G +P +E+ + PE +GE + + E E Q G +
Sbjct: 1851 ---VEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAE 1907
Query: 322 SGELEQEE-------ERLSKEWEDSKRWSKMDQLAKELTAEKR----------LEGQEEE 364
+ E E+E E L E ED + E A++ +E QE E
Sbjct: 1908 APEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAE 1967
Query: 365 EDNRDSSMKLSF------RARAYGFRGP------GPQLRRGWRPSSREDSLEA-GLPLQV 411
E+ + S + A G P P+ + + E E+ G+ Q
Sbjct: 1968 EEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQP 2027
Query: 412 RGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQ 452
+ EE +E EG + D + ES E E+ A + +
Sbjct: 2028 KSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAE 2068
Score = 48.1 bits (113), Expect = 2e-05
Identities = 52/212 (24%), Positives = 81/212 (38%), Gaps = 59/212 (27%)
Query: 101 EDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQE 160
EDE E Q + + L++ E ++V + E++ E T+G Q ++E
Sbjct: 1273 EDEAERDSEEQRASSNLEQLAENTVQEEV--------QLEETKEGTEGEGLQEEAVQLEE 1324
Query: 161 SKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAE 220
+K E Q G + EE +E +EG
Sbjct: 1325 TKTEEGLQEEGVQLEETKE-----------------------TEG--------------- 1346
Query: 221 PGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGA 280
+ ++EEE + EE E G E + EE + P G +GE+ E L +G
Sbjct: 1347 ---EGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGL----QGEALEEGLKEEGL 1399
Query: 281 GKPGA------EEAQDPEGKGEQEHSQQKEEE 306
+ G+ EA P+GKG QE +EEE
Sbjct: 1400 PEEGSVHGQELSEASSPDGKGSQEDDPVQEEE 1431
Score = 33.9 bits (76), Expect = 0.32
Identities = 67/280 (23%), Positives = 99/280 (35%), Gaps = 46/280 (16%)
Query: 168 QAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKR 227
++PG+ E +++ T A + +AE DSE Q + L+ + +
Sbjct: 1245 ESPGDLENQQQCCFPTFLNARACACATNEDEAERDSE--EQRASSNLEQLAENTVQEEVQ 1302
Query: 228 EEEEEEEEEAEA-GEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAE 286
EE +E E E EEAV EE T E L +G E
Sbjct: 1303 LEETKEGTEGEGLQEEAVQLEETKT--------------------EEGLQEEGVQ---LE 1339
Query: 287 EAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMD 346
E ++ EG+G+QE Q EE EE GE QEE +E ++
Sbjct: 1340 ETKETEGEGQQEEEAQLEEIEE------------TGGEGLQEEGVQLEEVKEGPEGG--- 1384
Query: 347 QLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAG 406
L E EG +EE + S+ + A G G Q + + +
Sbjct: 1385 -----LQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASA 1439
Query: 407 LPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEK 446
P G E + + P E +S S +E LEK
Sbjct: 1440 EPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEK 1479
>gi|221316599 chromogranin B precursor [Homo sapiens]
Length = 677
Score = 74.7 bits (182), Expect = 2e-13
Identities = 103/447 (23%), Positives = 170/447 (38%), Gaps = 61/447 (13%)
Query: 1 MRSAAVLALLLCAG--QVTALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSQEC-- 56
M+ +L+LL G V ++PV++ N + V +CI+EV+S+ LSK S P++ EC
Sbjct: 1 MQPTLLLSLLGAVGLAAVNSMPVDN-RNHNEGMVTRCIIEVLSNALSKSSAPPITPECRQ 59
Query: 57 -FETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHS-----GFEDELSEVLEN 110
+T R D + ++N E++ L AH+ G ED +
Sbjct: 60 VLKTSRKDVKDKETTENENTKFEVRLLRDPADASEAHESSSRGEAGAPGEEDIQGPTKAD 119
Query: 111 QSSQAE----LKEAVEE------PSSKDVME--KREDSKEAEKSGEATDGARPQALPEPM 158
AE +E +E PS V E K S+++++ E + E
Sbjct: 120 TEKWAEGGGHSRERADEPQWSLYPSDSQVSEEVKTRHSEKSQREDEEEEEGENYQKGERG 179
Query: 159 QESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLS 218
++S E + + PG E + N AS ++ ++E + G SQ + S
Sbjct: 180 EDSSEEKHLEEPG---ETQNAFLNERKQASAIKKEELVARSETHAAGHSQEKTHSREKSS 236
Query: 219 AEPGWQAKREEEEEEEEEAE--AGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALA 276
E G + +E +E + + + EE+ EE T E+ K +R
Sbjct: 237 QESGEETGSQENHPQESKGQPRSQEESEEGEEDAT-----------SEVDKRRTRPR--H 283
Query: 277 VDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEW 336
G +P E+ H Q++ EE +++ G R S EE E+
Sbjct: 284 HHGRSRPDRSSQGGSLPSEEKGHPQEESEESNVSMASLGEKRDHHSTHYRASEE--EPEY 341
Query: 337 EDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRP 396
+ + Q ++L E R G+ EE +R P PQ W
Sbjct: 342 GEEIKGYPGVQAPEDLEWE-RYRGRGSEE-----------------YRAPRPQSEESWDE 383
Query: 397 SSREDSLEAGLPLQVRGYPEEKKEEEG 423
+ + L GY EE +EE G
Sbjct: 384 EDKRNYPSLELDKMAHGYGEESEEERG 410
Score = 45.4 bits (106), Expect = 1e-04
Identities = 88/397 (22%), Positives = 138/397 (34%), Gaps = 65/397 (16%)
Query: 93 QQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQ 152
++K H E E S V S A L E + S+ S+E + GE G
Sbjct: 302 EEKGHPQEESEESNV-----SMASLGEKRDHHSTH-----YRASEEEPEYGEEIKGYPGV 351
Query: 153 ALPEPMQESKAEGNNQA------PGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGL 206
PE ++ + G P EE +EE +P L + + + GL
Sbjct: 352 QAPEDLEWERYRGRGSEEYRAPRPQSEESWDEEDKRNYPSLELDKMAHGYGEESEEERGL 411
Query: 207 SQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIR 266
G +G EP + EE+ E G V E + HP +KE+
Sbjct: 412 EPGKGRHHRGRGGEPRAYFMSDTREEKRFLGE-GHHRVQENQMDKA--RRHPQGAWKELD 468
Query: 267 KGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELE 326
+ L G PG + +Q Q +E E A + + E
Sbjct: 469 R-----NYLNYGEEGAPGKWQ--------QQGDLQDTKENREEARFQDKQYSSHHTAEKR 515
Query: 327 QEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEE-----------EDNRDSSMKLS 375
+ L + D +W ++ + LEG+EE E N D K
Sbjct: 516 KRLGELFNPYYDPLQWKSSHFERRDNMNDNFLEGEEENELTLNEKNFFPEYNYDWWEKKP 575
Query: 376 FRARA-YGF------RGPGPQLRR------------GWRPSSRE--DSLEAGLPLQVRGY 414
F +G+ R P L+R +R S E D ++ P+
Sbjct: 576 FSEDVNWGYEKRNLARVPKLDLKRQYDRVAQLDQLLHYRKKSAEFPDFYDSEEPVSTHQE 635
Query: 415 PE-EKKEEEGSANRRPEDQELESLSAIEAELEKVAHQ 450
E EK + + E +ELE+L+A++ EL+K+A +
Sbjct: 636 AENEKDRADQTVLTEDEKKELENLAAMDLELQKIAEK 672
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 66.2 bits (160), Expect = 6e-11
Identities = 106/418 (25%), Positives = 171/418 (40%), Gaps = 40/418 (9%)
Query: 51 PVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLEN 110
P+ ++ LR +ER R Q L E ++ Q ++R ++K+ E+E E L+
Sbjct: 789 PLREQRERQLRAEERQQ---REQRFLPEEEEKE-QRRRQRREREKELQFLEEE--EQLQR 842
Query: 111 QSSQAELKEAV----EEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGN 166
+ +L+E E+ + E+R D K + E R +P + +
Sbjct: 843 RERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKE 902
Query: 167 NQAPGEEEEE-EEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQA 225
Q EEEEE + E Q Q + + E L + +REK E Q
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLRE--EREKRRRQERERQY 960
Query: 226 KREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGA 285
+++++ +++EE GEE PE+ Y+E + + E L + K
Sbjct: 961 RKDKKLQQKEEQLLGEE--PEKRR-----RQEREKKYREEEELQQEEEQLLREEREKRRR 1013
Query: 286 EEAQDPEGKGE---QEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRW 342
+E + K + QE Q EE E + + + + EL+QEEE+L E +++R
Sbjct: 1014 QEWERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRR- 1072
Query: 343 SKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGP------QLRRGWRP 396
+L ++ E+ L+ QEEE+ R+ K + R R QL R R
Sbjct: 1073 --RQELERQYRKEEELQ-QEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE 1129
Query: 397 SSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPED---QELESLSAIEAELEKVAHQL 451
R LE Q R E ++EEE PE QELE E EL++ QL
Sbjct: 1130 KRRRQELER----QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQL 1183
Score = 63.9 bits (154), Expect = 3e-10
Identities = 84/405 (20%), Positives = 157/405 (38%), Gaps = 55/405 (13%)
Query: 71 RHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVM 130
+ Q LL+E ++ + +E+ +Q++ + +E E L+ + Q +E + +
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREE--EQLQQEEEQLLREEREKRRRQERER 958
Query: 131 EKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLP 190
+ R+D K +K E G P+ +E K + EEE+ E
Sbjct: 959 QYRKDKKLQQKE-EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWE 1017
Query: 191 SQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGP 250
Q + + + E L + +REK E Q + EEE ++EEE GEE
Sbjct: 1018 RQYRKKDELQQEEEQLLRE--EREKRRLQERERQYREEEELQQEEEQLLGEERETRRR-- 1073
Query: 251 TVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEA---QDPEGKGEQEHSQQKEEEE 307
+E+ + + E L + EE ++PE + QE +Q EEE
Sbjct: 1074 ------------QELERQYRKEEELQQE-------EEQLLREEPEKRRRQERERQCREEE 1114
Query: 308 EMAVVPQGLFRGGK--------------SGELEQEEERLSKEWEDSKRWSKMDQLAKE-- 351
E+ + L R + E++QEEE+L +E + +R ++++ +E
Sbjct: 1115 ELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE 1174
Query: 352 ---------LTAEKRLEGQEEEEDNR-DSSMKLSFRARAYGFRGPGPQLRRGWRPSSRED 401
L E+ QE E R + ++ R + Y L+ W P
Sbjct: 1175 ELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENA 1234
Query: 402 SLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEK 446
+ + + R + ++ E+ R Q+L+ L + E ++
Sbjct: 1235 VRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDR 1279
Score = 61.6 bits (148), Expect = 1e-09
Identities = 98/411 (23%), Positives = 165/411 (40%), Gaps = 51/411 (12%)
Query: 60 LRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKE 119
L+ +E L L Q L +E Q+ Q + R QQ + E+E E E + Q E +E
Sbjct: 271 LQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQ-EEERREQQEERREQQERRE 329
Query: 120 AVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEE-- 177
EE +RE E+ + R Q L +E + E + EEE E
Sbjct: 330 QQEE--------RREQQLRREQ-----EERREQQLRREQEEERREQQLRREQEEERREQQ 376
Query: 178 ---EEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEE-- 232
E+ Q Q + + + + RE+ L E Q +RE+EEE
Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ--QLRREQEEERH 434
Query: 233 ----EEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESR--SEALAVDGAGKPGAE 286
E+E E + EE + +E RK + + E + K E
Sbjct: 435 EQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEE 494
Query: 287 EAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQ---EEERLSKEWEDSKRWS 343
E ++ + + EQ+ +++EE E Q L R + L+Q E++L +E E+ +
Sbjct: 495 ERREQQERREQQLRREQEERRE-----QRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549
Query: 344 KMDQLAKELTAEKRLEG-QEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDS 402
+ K L E+R + + E+E+ RD +K R +L+R +E+
Sbjct: 550 LKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQ-------QRLKR-----EQEER 597
Query: 403 LEAGLPL-QVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQ 452
LE L +V +E++ E+ PE++ + L E + E+ QL+
Sbjct: 598 LEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR 648
Score = 61.2 bits (147), Expect = 2e-09
Identities = 82/371 (22%), Positives = 156/371 (42%), Gaps = 36/371 (9%)
Query: 77 KELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDS 136
+EL +L +G +E+ Q+++ + E E + + L++ E+ ++ +RE
Sbjct: 213 RELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ 272
Query: 137 KEAEKSGEAT-DGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYP 195
+E E+ + R + E Q+ + Q ++EEE E Q+
Sbjct: 273 EEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERRE----QQERR 328
Query: 196 GPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLN 255
Q E + L + +R + Q +RE+EEE E+ E+ EEE L
Sbjct: 329 EQQEERREQQLRREQEERREQ-------QLRREQEEERREQQLRREQ---EEERREQQLR 378
Query: 256 PHPSLGYKE-IRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQ 314
L ++ +R+ + + + E+ E + +E ++E+EEE
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE------ 432
Query: 315 GLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLE--GQEEEEDNRDSSM 372
R + E E+ E+RL +E E+ + W K ++ + E+R + +++EE+ R+ +
Sbjct: 433 ---RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWL 489
Query: 373 KLSFRARAYGFRGPGPQLRRGWRPSSREDSL-----EAGLPLQVRGYPEEKKEEEGSAN- 426
KL R QLRR + RE L E L ++R + ++E+E
Sbjct: 490 KLEEEERREQQERREQQLRRE-QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQ 548
Query: 427 --RRPEDQELE 435
+R E++ LE
Sbjct: 549 LLKREEEKRLE 559
Score = 57.0 bits (136), Expect = 3e-08
Identities = 81/384 (21%), Positives = 148/384 (38%), Gaps = 68/384 (17%)
Query: 70 LRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDV 129
LR + L+ Q L + R Q ++ E E Q + E +E + ++
Sbjct: 395 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE---QRLKREQ 451
Query: 130 MEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASL 189
E+R+ K E++ R Q L +E + E + EE E++E
Sbjct: 452 EERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Query: 190 PSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEG 249
++ + + + E L Q L + Q +RE+EE E+ + EE E+E
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQ---------QLRREQEERREQLLKREEEKRLEQE- 561
Query: 250 PTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEM 309
R + L K EE +D K E+E QQ+ + E+
Sbjct: 562 --------------------RREQRL------KREQEERRDQLLKREEERRQQRLKREQE 595
Query: 310 AVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRD 369
E+ E+RL +E ++++L +E E+RL+ +E EE+ R
Sbjct: 596 ----------------ERLEQRLKRE--------EVERLEQEERREQRLKREEPEEERRQ 631
Query: 370 SSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRP 429
+K + + Q R + RE+ E R + EE++E+E
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE-----LA 686
Query: 430 EDQELESLSAIEAELEKVAHQLQA 453
E+++ ++ I++ + K QL++
Sbjct: 687 EEEQEQARERIKSRIPKWQWQLES 710
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/371 (22%), Positives = 141/371 (38%), Gaps = 41/371 (11%)
Query: 78 ELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSK 137
E +D L+ + +QK+ E EL+E E Q L++ + +++ +R++ +
Sbjct: 123 EPRDRQLEEEPGQRRRQKRQEQ-ERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQ 181
Query: 138 EAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGP 197
E E+ +A E +Q K + P EE+ E Q+
Sbjct: 182 EREER---------RAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE 232
Query: 198 ------QAEGDSEGLSQGLV---DREKGLSAEPGWQAKREEEEEEEEEAEAGE--EAVPE 246
Q E + E + V + EK EP Q + +EEEE+ + E E E
Sbjct: 233 RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQE 292
Query: 247 EEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEH--SQQKE 304
EE L L K+ + + E + EE ++ + + EQE QQ
Sbjct: 293 EEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLR 352
Query: 305 EEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEE 364
E+E Q L R EQEEER ++ ++ + QL +E + + + E+
Sbjct: 353 REQEEERREQQLRR-------EQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 365 EDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGS 424
+ R+ ++ + R QLRR E E Q R K+E+E
Sbjct: 406 QLRREQQLRREQQLRR------EQQLRREQEEERHEQKHE-----QERREQRLKREQEER 454
Query: 425 ANRRPEDQELE 435
+ ++E E
Sbjct: 455 RDWLKREEETE 465
Score = 54.7 bits (130), Expect = 2e-07
Identities = 90/406 (22%), Positives = 163/406 (40%), Gaps = 82/406 (20%)
Query: 71 RHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEE-----PS 125
R Q L +E ++ L+ +R H++++ E EL+E E + ++ +K + + S
Sbjct: 655 REQRLKREEEEERLEQRLKREHEEERR---EQELAEE-EQEQARERIKSRIPKWQWQLES 710
Query: 126 SKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHP 185
D + + S+ ++ G+ + + E + + +A +++EEE+ T
Sbjct: 711 EADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQ 770
Query: 186 PASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVP 245
QAE SE Q L SA P + +RE + EE + + +P
Sbjct: 771 W-----------QAEEKSERGRQRL-------SARPPLREQRERQLRAEERQQREQRFLP 812
Query: 246 EEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEE 305
EEE KE R+ + R E ++ + E+E Q++E
Sbjct: 813 EEE-------------EKEQRRRQRR--------------EREKELQFLEEEEQLQRRER 845
Query: 306 EEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSK-RWSKMDQ-------------LAKE 351
+++ GL + +QE R ++ D K RW ++ L ++
Sbjct: 846 AQQLQEEEDGL-------QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQ 898
Query: 352 LTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQV 411
L E++L +EEEE R+ K + + +R QL++ RE+ + +
Sbjct: 899 LRKEQQLLQEEEEELQREEREKRRRQEQERQYR-EEEQLQQEEEQLLREEREKRRRQERE 957
Query: 412 RGYPEEKK---EEEGSANRRPED---QELESLSAIEAELEKVAHQL 451
R Y ++KK +EE PE QE E E EL++ QL
Sbjct: 958 RQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQL 1003
Score = 47.4 bits (111), Expect = 3e-05
Identities = 97/436 (22%), Positives = 163/436 (37%), Gaps = 55/436 (12%)
Query: 54 QECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELS----EVLE 109
++C E + +LR + + Q+L Q +E QQ++ +E + LE
Sbjct: 1108 RQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELE 1167
Query: 110 NQSSQAELKEAVEEPSSKDVMEKREDSKEAE--KSGEATDGARPQALP------------ 155
Q + E + EE ++ EKR +E + + E R Q
Sbjct: 1168 RQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQW 1227
Query: 156 EPMQESKAEGNN-QAPGEEEEEEEEATNTH---PPASLPSQKYPGPQAEGDSEGLSQGLV 211
EP +E+ N G E E+ + ++ + Q G Q E D E +
Sbjct: 1228 EPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQ 1287
Query: 212 DR------EKGLSAEPGWQAKREEEEEEEEEA---EAGEEAVPEEEGPTVVLNPHPSLGY 262
R E+ L E +AKR + + +EE+ E EE +E L
Sbjct: 1288 QRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQE 1347
Query: 263 KE---IRKGES----RSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQG 315
+E +R+ E R E L G+ EE Q + E+E KEE++ +
Sbjct: 1348 REEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLR-RQERERKFLKEEQQLRCQEREQ 1406
Query: 316 LFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRD------ 369
R + + +EE++LS++ D K + Q+ ++ K LE +++ R
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE 1466
Query: 370 -------SSMKLSFRARAYGFRGPGPQLRRGWRPSS-REDSLEAGLPLQVRGYPEEKKEE 421
+L + R F QLRR R RE L + P R + EE+++
Sbjct: 1467 EQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEP--ERKFLEEEQQL 1524
Query: 422 EGSANRRPEDQELESL 437
+R QE + L
Sbjct: 1525 HRQQRQRKFLQEEQQL 1540
Score = 44.7 bits (104), Expect = 2e-04
Identities = 76/334 (22%), Positives = 136/334 (40%), Gaps = 57/334 (17%)
Query: 159 QESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQ------------AEGDSEGL 206
+E +A + + ++ +EE P ++ PG + AEG+ +
Sbjct: 97 EEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE 156
Query: 207 SQG-LVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEG-PTVVLNPHPSLGYKE 264
Q L R++ E W+ ++E +E EE AE EE + +G T L +E
Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERRAE--EEQLQSCKGHETEEFPDEEQLRRRE 214
Query: 265 I----RKGESRSEALAVDGAGKPGAEEAQDP-----------EGKGEQEHSQ-----QKE 304
+ RKG + + + EE + E K ++E Q Q+E
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 305 EEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEE 364
EE+ + Q L R + E EQ+++RL +E + +R + ++ ++ ++ E +E++
Sbjct: 275 EEQLRKLERQELRR--ERQEEEQQQQRLRRE-QQLRRKQEEERREQQEERREQQERREQQ 331
Query: 365 EDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGS 424
E+ R+ ++ R QLRR RE L R EE++E++
Sbjct: 332 EERREQQLRREQEERR------EQQLRREQEEERREQQLR-------REQEEERREQQ-- 376
Query: 425 ANRRPEDQELESLSAIEAEL--EKVAHQLQALRR 456
RR + E E +L E+ + Q LRR
Sbjct: 377 -LRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Score = 44.7 bits (104), Expect = 2e-04
Identities = 82/413 (19%), Positives = 158/413 (38%), Gaps = 39/413 (9%)
Query: 71 RHQNLLKELQDLALQGAKERAHQQKKHSGFEDEL----SEVLENQSSQAELKE------- 119
+ Q +EL + Q K+ +Q+ ++EL E E + +AE ++
Sbjct: 140 KRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH 199
Query: 120 AVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEE 179
EE ++ + +RE + K E R + QE + + + +EEE+
Sbjct: 200 ETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEK 259
Query: 180 ATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDRE---KGLSAEPGWQAKREEE--EEEE 234
P Q+ + + + L + + E + L E + K+EEE E++E
Sbjct: 260 LQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQE 319
Query: 235 EEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGK 294
E E E +EE L +E + + E + EE ++ + +
Sbjct: 320 ERREQQERREQQEERREQQLRREQE-ERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 295 GEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQE---------EERLSKEWEDSKRWSKM 345
EQ+ ++++ E + + R + EQ+ E++L +E E+ + K
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 346 DQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEA 405
+Q E+R + + E++ R +K + QL+R E+ E
Sbjct: 439 EQ-------ERREQRLKREQEERRDWLKREEETERHEQERRKQQLKR----DQEEERRER 487
Query: 406 GLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAE--LEKVAHQLQALRR 456
L L+ E+++ E R E++ + L E E L++ Q LRR
Sbjct: 488 WLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Score = 43.5 bits (101), Expect = 4e-04
Identities = 65/367 (17%), Positives = 149/367 (40%), Gaps = 36/367 (9%)
Query: 61 RGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGF-EDELSEVLENQSSQAELKE 119
R +E++ Q L ++ +D + +++ +Q++ F EDE + L Q Q +L++
Sbjct: 1558 REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDE--QQLRRQEGQQQLRQ 1615
Query: 120 AVEEPSSKD---VMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEE 176
+ +D + E+ E ++ PQ + ++ ++ EEE+
Sbjct: 1616 ERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQL 1675
Query: 177 EEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEE 236
+E +K+ + + + + + E+ L + + +R+ EEE+
Sbjct: 1676 LQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQ---ELERKFREEEQLR 1732
Query: 237 AEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGE 296
E +E + +E +L +E + E + L + +D + + E
Sbjct: 1733 QETEQEQLRRQERYRKILE-------EEQLRPEREEQQLR---------RQERDRKFREE 1776
Query: 297 QEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSK-RWSKMDQLAKELTAE 355
++ Q++EE++ + FR + E+EE++L + D K RW + +QL E E
Sbjct: 1777 EQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEE-EQLQLE-EQE 1834
Query: 356 KRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYP 415
+RL + + + + ++R + + W+ ++ E L+
Sbjct: 1835 QRLRQERDRQYRAEEQFATQEKSRR--------EEQELWQEEEQKRRQERERKLREEHIR 1886
Query: 416 EEKKEEE 422
++KEE+
Sbjct: 1887 RQQKEEQ 1893
Score = 41.2 bits (95), Expect = 0.002
Identities = 81/436 (18%), Positives = 160/436 (36%), Gaps = 61/436 (13%)
Query: 71 RHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVM 130
R +E + L + +E+ +Q+ F +E + E + +E + +++
Sbjct: 1309 RRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Query: 131 EKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLP 190
+ + K E+ R + + Q+ + + Q ++ + +
Sbjct: 1369 HQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQER 1428
Query: 191 SQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGP 250
+K+ + + + + ++ E+ L E R+ EEE+ E E+ + +E
Sbjct: 1429 DRKFREEEQQVRRQERERKFLEEEQQLRQE----RHRKFREEEQLLQEREEQQLHRQERD 1484
Query: 251 TVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQ-------------DPEGKGEQ 297
L L +E R + R + L + EE Q + + Q
Sbjct: 1485 RKFLEEEQQLRRQE-RDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQ 1543
Query: 298 EHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSK------RWSKMDQLAKE 351
E QQ+ ++ + FR + E+EE++LS++ D K + + +Q K
Sbjct: 1544 ERGQQRRQDRDRK------FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKF 1597
Query: 352 LTAEKRL---EGQEEEEDNRD-------------SSMKLSFRARAYGFRGPGPQLRRGWR 395
+ E++L EGQ++ RD +L + R F PQLRR R
Sbjct: 1598 MEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657
Query: 396 PS-----------SREDSLEAGLPLQVRGYPEEKK--EEEGSANRRPEDQEL--ESLSAI 440
E L+ G Q+R ++K EEE R+ +++ E
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLR 1717
Query: 441 EAELEKVAHQLQALRR 456
ELE+ + + LR+
Sbjct: 1718 RQELERKFREEEQLRQ 1733
Score = 30.8 bits (68), Expect = 2.7
Identities = 40/206 (19%), Positives = 81/206 (39%), Gaps = 26/206 (12%)
Query: 58 ETLRGDERILSILRHQNLLKELQDLALQGAKE--RAHQQKKHSGFEDELSEVLENQSSQA 115
E LR + + R + K L++ L+ +E + +Q++ F +E E L + +
Sbjct: 1729 EQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREE--EQLRQEREEQ 1786
Query: 116 ELKEAVEEPSSKDVMEKREDSKEAEKSGEATDG-----ARPQALPEPMQESKAEGNNQAP 170
+L+ + ++ + R++ +E + + DG L E Q + E + Q
Sbjct: 1787 QLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR 1846
Query: 171 GEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEE 230
EE+ +E + ++ Q +RE+ L E R ++
Sbjct: 1847 AEEQFATQEKSRREEQELWQEEEQKRRQ-------------ERERKLREE----HIRRQQ 1889
Query: 231 EEEEEEAEAGEEAVPEEEGPTVVLNP 256
+EE+ + GE E +G +L P
Sbjct: 1890 KEEQRHRQVGEIKSQEGKGHGRLLEP 1915
>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
8 [Homo sapiens]
Length = 780
Score = 63.5 bits (153), Expect = 4e-10
Identities = 58/264 (21%), Positives = 106/264 (40%), Gaps = 23/264 (8%)
Query: 87 AKERAHQQKKHSG---FEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSG 143
A+E + +++ + G F D L ++ + + +++E +E + E+R + + E+
Sbjct: 146 AREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREA 205
Query: 144 EATDGARPQALPEPMQES-KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD 202
A + + E + KA +++P E E + P + ++
Sbjct: 206 RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ 265
Query: 203 SEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGY 262
S+ + SAE G ++ EEEEEEEEE E EEE
Sbjct: 266 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE-------------- 311
Query: 263 KEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKS 322
+E + E + A + AEE + E +++E E + VVP+ F S
Sbjct: 312 EEEEEEEEEETGSNSEEASEQSAEEVSEE----EMSEDEERENENHLLVVPESRF-DRDS 366
Query: 323 GELEQEEERLSKEWEDSKRWSKMD 346
GE E+ EE + + S ++ D
Sbjct: 367 GESEEAEEEVGEGTPQSSALTEGD 390
Score = 48.5 bits (114), Expect = 1e-05
Identities = 60/288 (20%), Positives = 104/288 (36%), Gaps = 37/288 (12%)
Query: 88 KERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSK----DVMEKREDSKEAEKSG 143
KE+ H +K E + + V E + K EE + ++RE ++E +
Sbjct: 94 KEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 153
Query: 144 EATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDS 203
DG E K E + +++E+ E+ ++ +
Sbjct: 154 RGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHH 213
Query: 204 EGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYK 263
+ + D+ K W E E G + V EE+
Sbjct: 214 RTMREDYSDKVKASH----WSRSPPRPPRERFELGDGRKPVKEEK--------------M 255
Query: 264 EIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSG 323
E R S + ++ AE + G G +E +++EEEEE G S
Sbjct: 256 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE---------EGSTSE 306
Query: 324 ELEQEEERLSKEWEDSKRWSK----MDQLAKELTAEKRLEGQEEEEDN 367
E E+EEE +E E+ + S +Q A+E++ E+ E +E E +N
Sbjct: 307 ESEEEEEE--EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 352
Score = 38.1 bits (87), Expect = 0.017
Identities = 78/333 (23%), Positives = 126/333 (37%), Gaps = 70/333 (21%)
Query: 93 QQKKHSGFEDELSEV--LENQSSQAELKEAVEEPSSKD-VME--------KREDSKEAEK 141
Q+KK ++E +E+ L+N + ++++EE +D ME +REDS E
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDR- 76
Query: 142 SGEATDGARPQALPEPMQESKAEGNNQAPGE-----------EEEEEEEATNTHPPASLP 190
GE D A+ P Q S+ E + E E+E E E H
Sbjct: 77 -GEEDDSL---AIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDK 132
Query: 191 SQKYPGPQA-----------EGDSEGLS---QGLVDREKGLSAEPGWQAKREEEEEEEEE 236
+++ Q E ++G+ L E+ E + +++E+ E++E
Sbjct: 133 ARREWERQKRREMAREHSRRERGNDGVCLFRDRLEQLERKRERERKMREQQKEQREQKER 192
Query: 237 AEAGEEAVPEEEGPTVVLNPHPSL--GYKEIRKGE--SRS------EALAVDGAGKPGAE 286
EE E E V H ++ Y + K SRS E + KP E
Sbjct: 193 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 252
Query: 287 EAQDPEGK----GEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRW 342
E + + S++K E + G SG E+EEE +E E S
Sbjct: 253 EKMEERDLLSDLQDISDSERKTSSAESSSAESG------SGSEEEEEEEEEEEEEGS--- 303
Query: 343 SKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLS 375
E + E+ E +EEEE+ +S + S
Sbjct: 304 ------TSEESEEEEEEEEEEEEETGSNSEEAS 330
>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
5 [Homo sapiens]
Length = 748
Score = 62.0 bits (149), Expect = 1e-09
Identities = 73/331 (22%), Positives = 126/331 (38%), Gaps = 45/331 (13%)
Query: 42 DTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKK----- 96
D+L+ P +S++ R DE+ RH++ E A KER H+++K
Sbjct: 47 DSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREE 106
Query: 97 -------------------HSGFE-DELSEVLENQSSQAELKEAVEEPSSKDVMEKREDS 136
HS E D L ++ + + +++E +E + E+R +
Sbjct: 107 QDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 166
Query: 137 KEAEKSGEATDGARPQALPEPMQES-KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYP 195
+ E+ A + + E + KA +++P E E + P +
Sbjct: 167 RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER 226
Query: 196 GPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLN 255
++ S+ + SAE G ++ EEEEEEEEE E EEE
Sbjct: 227 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE------- 279
Query: 256 PHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQG 315
+E + E + A + AEE + E +++E E + VVP+
Sbjct: 280 -------EEEEEEEEEETGSNSEEASEQSAEEVSEE----EMSEDEERENENHLLVVPES 328
Query: 316 LFRGGKSGELEQEEERLSKEWEDSKRWSKMD 346
F SGE E+ EE + + S ++ D
Sbjct: 329 RF-DRDSGESEEAEEEVGEGTPQSSALTEGD 358
Score = 33.5 bits (75), Expect = 0.41
Identities = 52/286 (18%), Positives = 106/286 (37%), Gaps = 32/286 (11%)
Query: 172 EEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEE 231
E+ EE+++ PP + S+K + + + R + SAE G A+ +E+E
Sbjct: 40 EDRGEEDDSLAIKPPQQM-SRKEKVHHRKDEKRKEKR----RHRSHSAEGGKHARVKEKE 94
Query: 232 EEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDP 291
E E + E ++ + + R+ R E L E ++
Sbjct: 95 REHERRKRHREE-QDKARREWERQKRREMAREHSRRERDRLEQL----------ERKRER 143
Query: 292 EGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWED---SKRWSKMDQL 348
E K ++ +Q+E++E + E+ + +++ D + WS+
Sbjct: 144 ERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPR 203
Query: 349 ----------AKELTAEKRLEGQE---EEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWR 395
++ E+++E ++ + +D DS K S + G G +
Sbjct: 204 PPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE 263
Query: 396 PSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIE 441
E+ + + EE++EE GS + +Q E +S E
Sbjct: 264 EEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEE 309
>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
2 [Homo sapiens]
Length = 782
Score = 62.0 bits (149), Expect = 1e-09
Identities = 73/331 (22%), Positives = 126/331 (38%), Gaps = 45/331 (13%)
Query: 42 DTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKK----- 96
D+L+ P +S++ R DE+ RH++ E A KER H+++K
Sbjct: 81 DSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRHREE 140
Query: 97 -------------------HSGFE-DELSEVLENQSSQAELKEAVEEPSSKDVMEKREDS 136
HS E D L ++ + + +++E +E + E+R +
Sbjct: 141 QDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEE 200
Query: 137 KEAEKSGEATDGARPQALPEPMQES-KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYP 195
+ E+ A + + E + KA +++P E E + P +
Sbjct: 201 RRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEER 260
Query: 196 GPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLN 255
++ S+ + SAE G ++ EEEEEEEEE E EEE
Sbjct: 261 DLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE------- 313
Query: 256 PHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQG 315
+E + E + A + AEE + E +++E E + VVP+
Sbjct: 314 -------EEEEEEEEEETGSNSEEASEQSAEEVSEE----EMSEDEERENENHLLVVPES 362
Query: 316 LFRGGKSGELEQEEERLSKEWEDSKRWSKMD 346
F SGE E+ EE + + S ++ D
Sbjct: 363 RF-DRDSGESEEAEEEVGEGTPQSSALTEGD 392
Score = 41.6 bits (96), Expect = 0.002
Identities = 80/335 (23%), Positives = 125/335 (37%), Gaps = 72/335 (21%)
Query: 93 QQKKHSGFEDELSEV--LENQSSQAELKEAVEEPSSKDV-ME--------KREDSKEAEK 141
Q+KK ++E +E+ L+N + ++++EE +D ME +REDS E
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDR- 76
Query: 142 SGEATDGARPQALPEPMQESK----------------------AEGNNQAPGEEEEEEEE 179
GE D A+ P Q S+ AEG A +E+E E E
Sbjct: 77 -GEEDDSL---AIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHE 132
Query: 180 ATNTHPPASLPSQKYPGPQ-----AEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEE 234
H +++ Q A S L E+ E + +++E+ E++
Sbjct: 133 RRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQK 192
Query: 235 EEAEAGEEAVPEEEGPTVVLNPHPSL--GYKEIRKGE--SRS------EALAVDGAGKPG 284
E EE E E V H ++ Y + K SRS E + KP
Sbjct: 193 ERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPV 252
Query: 285 AEEAQDPEGK----GEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSK 340
EE + + S++K E + G SG E+EEE +E E S
Sbjct: 253 KEEKMEERDLLSDLQDISDSERKTSSAESSSAESG------SGSEEEEEEEEEEEEEGS- 305
Query: 341 RWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLS 375
E + E+ E +EEEE+ +S + S
Sbjct: 306 --------TSEESEEEEEEEEEEEEETGSNSEEAS 332
Score = 38.1 bits (87), Expect = 0.017
Identities = 63/354 (17%), Positives = 132/354 (37%), Gaps = 39/354 (11%)
Query: 104 LSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKA 163
L E+L+ + + E +E E K+ + R+ +++ + GE D + +
Sbjct: 13 LDEILQEKKRRKEQEEKAEIKRLKN-SDDRDSKRDSLEEGELRDHRMEITI------RNS 65
Query: 164 EGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGW 223
+ E+ EE+++ PP + S+K + + + R + SAE G
Sbjct: 66 PYRREDSMEDRGEEDDSLAIKPPQQM-SRKEKVHHRKDEKRKEKR----RHRSHSAEGGK 120
Query: 224 QAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKP 283
A+ +E+E E E + E ++ + + R+ R E L
Sbjct: 121 HARVKEKEREHERRKRHREE-QDKARREWERQKRREMAREHSRRERDRLEQL-------- 171
Query: 284 GAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWED---SK 340
E ++ E K ++ +Q+E++E + E+ + +++ D +
Sbjct: 172 --ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKAS 229
Query: 341 RWSKMDQL----------AKELTAEKRLEGQE---EEEDNRDSSMKLSFRARAYGFRGPG 387
WS+ ++ E+++E ++ + +D DS K S + G G
Sbjct: 230 HWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSG 289
Query: 388 PQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIE 441
+ E+ + + EE++EE GS + +Q E +S E
Sbjct: 290 SEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEE 343
>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
Length = 770
Score = 61.2 bits (147), Expect = 2e-09
Identities = 58/261 (22%), Positives = 104/261 (39%), Gaps = 21/261 (8%)
Query: 88 KERAHQQKKHSGFE-DELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEAT 146
++R ++HS E D L ++ + + +++E +E + E+R + + E+
Sbjct: 139 QKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARRE 198
Query: 147 DGARPQALPEPMQES-KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEG 205
A + + E + KA +++P E E + P + ++
Sbjct: 199 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS 258
Query: 206 LSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEI 265
S+ + SAE G ++ EEEEEEEEE E EEE +E
Sbjct: 259 DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE--------------EEE 304
Query: 266 RKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGEL 325
+ E + A + AEE + E +++E E + VVP+ F SGE
Sbjct: 305 EEEEEEETGSNSEEASEQSAEEVSEE----EMSEDEERENENHLLVVPESRF-DRDSGES 359
Query: 326 EQEEERLSKEWEDSKRWSKMD 346
E+ EE + + S ++ D
Sbjct: 360 EEAEEEVGEGTPQSSALTEGD 380
Score = 47.0 bits (110), Expect = 4e-05
Identities = 61/283 (21%), Positives = 106/283 (37%), Gaps = 58/283 (20%)
Query: 88 KERAHQQKK-HSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEAT 146
KER H+++K H +D+ E Q + +E +D +E+ E +E E+
Sbjct: 115 KEREHERRKRHREEQDKARREWERQKRREMARE--HSRRERDRLEQLERKRERERK---- 168
Query: 147 DGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGL 206
+ E +E + + + EE +E EA + +
Sbjct: 169 -------MREQQKEQREQKERERRAEERRKEREARR---------------EVSAHHRTM 206
Query: 207 SQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEE-GPTVVLNPHPSLGYKEI 265
+ D+ K W E E G + V EE+ +L+ + E
Sbjct: 207 REDYSDKVKASH----WSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSE- 261
Query: 266 RKGESRSEALAVDGAG-KPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGE 324
RK S + A G+G + EE ++ E +G ++EEEEE
Sbjct: 262 RKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEE---------------- 305
Query: 325 LEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDN 367
E+EEE E++ +Q A+E++ E+ E +E E +N
Sbjct: 306 -EEEEEETGSNSEEAS-----EQSAEEVSEEEMSEDEERENEN 342
Score = 40.4 bits (93), Expect = 0.003
Identities = 77/323 (23%), Positives = 123/323 (38%), Gaps = 60/323 (18%)
Query: 93 QQKKHSGFEDELSEV--LENQSSQAELKEAVEEPSSKD-VME--------KREDSKEAEK 141
Q+KK ++E +E+ L+N + ++++EE +D ME +REDS E
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDR- 76
Query: 142 SGEATDGARPQALPEPMQESKAEGNNQAPGEEEEE----------EEEATNTHPPASLPS 191
GE D A+ P Q S+ E + E+ +E E E H +
Sbjct: 77 -GEEDDSL---AIKPPQQMSRKEKVHHRKDEKRKEKWKHARVKEREHERRKRHREEQDKA 132
Query: 192 QKYPGPQ-----AEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPE 246
++ Q A S L E+ E + +++E+ E++E EE E
Sbjct: 133 RREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE 192
Query: 247 EEGPTVVLNPHPSL--GYKEIRKGE--SRS------EALAVDGAGKPGAEEAQDPEGK-- 294
E V H ++ Y + K SRS E + KP EE +
Sbjct: 193 REARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLS 252
Query: 295 --GEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKEL 352
+ S++K E + G SG E+EEE +E E S E
Sbjct: 253 DLQDISDSERKTSSAESSSAESG------SGSEEEEEEEEEEEEEGS---------TSEE 297
Query: 353 TAEKRLEGQEEEEDNRDSSMKLS 375
+ E+ E +EEEE+ +S + S
Sbjct: 298 SEEEEEEEEEEEEETGSNSEEAS 320
Score = 33.9 bits (76), Expect = 0.32
Identities = 60/348 (17%), Positives = 123/348 (35%), Gaps = 72/348 (20%)
Query: 104 LSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKA 163
L E+L+ + + E +E E K+ + R+ +++ + GE D + +
Sbjct: 13 LDEILQEKKRRKEQEEKAEIKRLKN-SDDRDSKRDSLEEGELRDHCMEITI------RNS 65
Query: 164 EGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGW 223
+ E+ EE+++ PP + ++ V K + W
Sbjct: 66 PYRREDSMEDRGEEDDSLAIKPPQQMSRKEK----------------VHHRKDEKRKEKW 109
Query: 224 QAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKP 283
+ R +E E E EE ++ + + R+ R E L
Sbjct: 110 KHARVKEREHERRKRHREEQ--DKARREWERQKRREMAREHSRRERDRLEQL-------- 159
Query: 284 GAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWED---SK 340
E ++ E K ++ +Q+E++E + E+ + +++ D +
Sbjct: 160 --ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKAS 217
Query: 341 RWSKMDQL----------AKELTAEKRLEGQE---EEEDNRDSSMKLSFRARAYGFRGPG 387
WS+ ++ E+++E ++ + +D DS K S
Sbjct: 218 HWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTS------------ 265
Query: 388 PQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELE 435
S+ S E+G + EE++EEEGS + E++E E
Sbjct: 266 ---------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 304
>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
Length = 780
Score = 61.2 bits (147), Expect = 2e-09
Identities = 58/261 (22%), Positives = 104/261 (39%), Gaps = 21/261 (8%)
Query: 88 KERAHQQKKHSGFE-DELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEAT 146
++R ++HS E D L ++ + + +++E +E + E+R + + E+
Sbjct: 149 QKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARRE 208
Query: 147 DGARPQALPEPMQES-KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEG 205
A + + E + KA +++P E E + P + ++
Sbjct: 209 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS 268
Query: 206 LSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEI 265
S+ + SAE G ++ EEEEEEEEE E EEE +E
Sbjct: 269 DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE--------------EEE 314
Query: 266 RKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGEL 325
+ E + A + AEE + E +++E E + VVP+ F SGE
Sbjct: 315 EEEEEEETGSNSEEASEQSAEEVSEE----EMSEDEERENENHLLVVPESRF-DRDSGES 369
Query: 326 EQEEERLSKEWEDSKRWSKMD 346
E+ EE + + S ++ D
Sbjct: 370 EEAEEEVGEGTPQSSALTEGD 390
Score = 48.9 bits (115), Expect = 9e-06
Identities = 72/329 (21%), Positives = 124/329 (37%), Gaps = 60/329 (18%)
Query: 42 DTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKK-HSGF 100
D+L+ P +S++ R DE+ RH + E A KER H+++K H
Sbjct: 81 DSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHAR--VKEREHERRKRHREE 138
Query: 101 EDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQE 160
+D+ E Q + +E +D +E+ E +E E+ + E +E
Sbjct: 139 QDKARREWERQKRREMARE--HSRRERDRLEQLERKRERERK-----------MREQQKE 185
Query: 161 SKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAE 220
+ + + EE +E EA + + + D+ K
Sbjct: 186 QREQKERERRAEERRKEREARR---------------EVSAHHRTMREDYSDKVKASH-- 228
Query: 221 PGWQAKREEEEEEEEEAEAGEEAVPEEE-GPTVVLNPHPSLGYKEIRKGESRSEALAVDG 279
W E E G + V EE+ +L+ + E RK S + A G
Sbjct: 229 --WSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSE-RKTSSAESSSAESG 285
Query: 280 AG-KPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWED 338
+G + EE ++ E +G ++EEEEE E+EEE E+
Sbjct: 286 SGSEEEEEEEEEEEEEGSTSEESEEEEEEE-----------------EEEEEETGSNSEE 328
Query: 339 SKRWSKMDQLAKELTAEKRLEGQEEEEDN 367
+ +Q A+E++ E+ E +E E +N
Sbjct: 329 AS-----EQSAEEVSEEEMSEDEERENEN 352
Score = 38.1 bits (87), Expect = 0.017
Identities = 65/349 (18%), Positives = 127/349 (36%), Gaps = 64/349 (18%)
Query: 104 LSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKA 163
L E+L+ + + E +E E K+ + R+ +++ + GE D + +
Sbjct: 13 LDEILQEKKRRKEQEEKAEIKRLKN-SDDRDSKRDSLEEGELRDHCMEITI------RNS 65
Query: 164 EGNNQAPGEEEEEEEEATNTHPPASLP-SQKYPGPQAEGDSEGLSQGLVDREKGLSAEPG 222
+ E+ EE+++ PP + +K + E E R SAE G
Sbjct: 66 PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKC------RHHSHSAEGG 119
Query: 223 WQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGK 282
A+ +E E E + E+ E + + R+ R E L
Sbjct: 120 KHARVKEREHERRKRHREEQDKARREWER---QKRREMAREHSRRERDRLEQL------- 169
Query: 283 PGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWED---S 339
E ++ E K ++ +Q+E++E + E+ + +++ D +
Sbjct: 170 ---ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKA 226
Query: 340 KRWSKMDQL----------AKELTAEKRLEGQE---EEEDNRDSSMKLSFRARAYGFRGP 386
WS+ ++ E+++E ++ + +D DS K S
Sbjct: 227 SHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTS----------- 275
Query: 387 GPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELE 435
S+ S E+G + EE++EEEGS + E++E E
Sbjct: 276 ----------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 314
Score = 37.4 bits (85), Expect = 0.029
Identities = 77/333 (23%), Positives = 121/333 (36%), Gaps = 70/333 (21%)
Query: 93 QQKKHSGFEDELSEV--LENQSSQAELKEAVEEPSSKD-VME--------KREDSKEAEK 141
Q+KK ++E +E+ L+N + ++++EE +D ME +REDS E
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDR- 76
Query: 142 SGEATDGARPQALPEPMQESK----------------------AEGNNQAPGEEEEEEEE 179
GE D A+ P Q S+ AEG A +E E E
Sbjct: 77 -GEEDDSL---AIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKHARVKEREHERR 132
Query: 180 ATNTHPPASLPSQ---KYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEE 236
+ + + A S L E+ E + +++E+ E++E
Sbjct: 133 KRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKER 192
Query: 237 AEAGEEAVPEEEGPTVVLNPHPSL--GYKEIRKGE--SRS------EALAVDGAGKPGAE 286
EE E E V H ++ Y + K SRS E + KP E
Sbjct: 193 ERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKE 252
Query: 287 EAQDPEGK----GEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRW 342
E + + S++K E + G SG E+EEE +E E S
Sbjct: 253 EKMEERDLLSDLQDISDSERKTSSAESSSAESG------SGSEEEEEEEEEEEEEGS--- 303
Query: 343 SKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLS 375
E + E+ E +EEEE+ +S + S
Sbjct: 304 ------TSEESEEEEEEEEEEEEETGSNSEEAS 330
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 61.2 bits (147), Expect = 2e-09
Identities = 58/261 (22%), Positives = 104/261 (39%), Gaps = 21/261 (8%)
Query: 88 KERAHQQKKHSGFE-DELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEAT 146
++R ++HS E D L ++ + + +++E +E + E+R + + E+
Sbjct: 140 QKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARRE 199
Query: 147 DGARPQALPEPMQES-KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEG 205
A + + E + KA +++P E E + P + ++
Sbjct: 200 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS 259
Query: 206 LSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEI 265
S+ + SAE G ++ EEEEEEEEE E EEE +E
Sbjct: 260 DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE--------------EEE 305
Query: 266 RKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGEL 325
+ E + A + AEE + E +++E E + VVP+ F SGE
Sbjct: 306 EEEEEEETGSNSEEASEQSAEEVSEE----EMSEDEERENENHLLVVPESRF-DRDSGES 360
Query: 326 EQEEERLSKEWEDSKRWSKMD 346
E+ EE + + S ++ D
Sbjct: 361 EEAEEEVGEGTPQSSALTEGD 381
Score = 48.5 bits (114), Expect = 1e-05
Identities = 78/342 (22%), Positives = 128/342 (37%), Gaps = 83/342 (24%)
Query: 93 QQKKHSGFEDELSEV--LENQSSQAELKEAVEEPSSKD-VME--------KREDSKEAEK 141
Q+KK ++E +E+ L+N + ++++EE +D ME +REDS E
Sbjct: 18 QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDR- 76
Query: 142 SGEATDGARPQALPEPMQESKAEGNNQAPGE-----------EEEEEEEATNTHPPASLP 190
GE D A+ P Q S+ E + E E+E E E H
Sbjct: 77 -GEEDDSL---AIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDK 132
Query: 191 SQKYPGPQ-----AEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVP 245
+++ Q A S L E+ E + +++E+ E++E EE
Sbjct: 133 ARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRK 192
Query: 246 EEEGPTVVLNPHPSL-----------------------------GYKEIRKGESRSEALA 276
E E V H ++ G K +++ + L
Sbjct: 193 EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLL 252
Query: 277 VD-------GAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEE 329
D AE + G G +E +++EEEEE G S E E+EE
Sbjct: 253 SDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE---------EGSTSEESEEEE 303
Query: 330 ERLSKEWEDSKRWSK----MDQLAKELTAEKRLEGQEEEEDN 367
E +E E+ + S +Q A+E++ E+ E +E E +N
Sbjct: 304 EE--EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 343
Score = 33.9 bits (76), Expect = 0.32
Identities = 61/349 (17%), Positives = 128/349 (36%), Gaps = 73/349 (20%)
Query: 104 LSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKA 163
L E+L+ + + E +E E K+ + R+ +++ + GE D + +
Sbjct: 13 LDEILQEKKRRKEQEEKAEIKRLKN-SDDRDSKRDSLEEGELRDHCMEITI------RNS 65
Query: 164 EGNNQAPGEEEEEEEEATNTHPPASLP-SQKYPGPQAEGDSEGLSQGLVDREKGLSAEPG 222
+ E+ EE+++ PP + +K + E E + ++E+
Sbjct: 66 PYRREDSMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKERE------ 119
Query: 223 WQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGK 282
+R+ EE+++A E E + + R+ R E L
Sbjct: 120 -HERRKRHREEQDKARREWERQKRRE-----------MAREHSRRERDRLEQL------- 160
Query: 283 PGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWED---S 339
E ++ E K ++ +Q+E++E + E+ + +++ D +
Sbjct: 161 ---ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKA 217
Query: 340 KRWSKMDQL----------AKELTAEKRLEGQE---EEEDNRDSSMKLSFRARAYGFRGP 386
WS+ ++ E+++E ++ + +D DS K S
Sbjct: 218 SHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTS----------- 266
Query: 387 GPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELE 435
S+ S E+G + EE++EEEGS + E++E E
Sbjct: 267 ----------SAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEE 305
>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
4 [Homo sapiens]
Length = 737
Score = 61.2 bits (147), Expect = 2e-09
Identities = 58/261 (22%), Positives = 104/261 (39%), Gaps = 21/261 (8%)
Query: 88 KERAHQQKKHSGFE-DELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEAT 146
++R ++HS E D L ++ + + +++E +E + E+R + + E+
Sbjct: 106 QKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARRE 165
Query: 147 DGARPQALPEPMQES-KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEG 205
A + + E + KA +++P E E + P + ++
Sbjct: 166 VSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDIS 225
Query: 206 LSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEI 265
S+ + SAE G ++ EEEEEEEEE E EEE +E
Sbjct: 226 DSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE--------------EEE 271
Query: 266 RKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGEL 325
+ E + A + AEE + E +++E E + VVP+ F SGE
Sbjct: 272 EEEEEEETGSNSEEASEQSAEEVSEE----EMSEDEERENENHLLVVPESRF-DRDSGES 326
Query: 326 EQEEERLSKEWEDSKRWSKMD 346
E+ EE + + S ++ D
Sbjct: 327 EEAEEEVGEGTPQSSALTEGD 347
Score = 48.1 bits (113), Expect = 2e-05
Identities = 59/284 (20%), Positives = 103/284 (36%), Gaps = 38/284 (13%)
Query: 88 KERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATD 147
KE+ H +K E + + V E + K EE +R+ +E + +
Sbjct: 60 KEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRE 119
Query: 148 GARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLS 207
R + L E K E + +++E+ E+ ++ + +
Sbjct: 120 RDRLEQL-----ERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMR 174
Query: 208 QGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRK 267
+ D+ K W E E G + V EE+ E R
Sbjct: 175 EDYSDKVKASH----WSRSPPRPPRERFELGDGRKPVKEEK--------------MEERD 216
Query: 268 GESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQ 327
S + ++ AE + G G +E +++EEEEE G S E E+
Sbjct: 217 LLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEE---------EGSTSEESEE 267
Query: 328 EEERLSKEWEDSKRWSK----MDQLAKELTAEKRLEGQEEEEDN 367
EEE +E E+ + S +Q A+E++ E+ E +E E +N
Sbjct: 268 EEEE--EEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENEN 309
Score = 36.2 bits (82), Expect = 0.064
Identities = 69/292 (23%), Positives = 108/292 (36%), Gaps = 50/292 (17%)
Query: 114 QAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGE- 172
+ EL++ E + ++ +REDS E GE D A+ P Q S+ E + E
Sbjct: 16 EGELRDHRMEITIRNSPYRREDSMEDR--GEEDDSL---AIKPPQQMSRKEKVHHRKDEK 70
Query: 173 ----------EEEEEEEATNTHPPASLPSQKYPGPQ-----AEGDSEGLSQGLVDREKGL 217
E+E E E H +++ Q A S L E+
Sbjct: 71 RKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKR 130
Query: 218 SAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSL--GYKEIRKGE--SRS- 272
E + +++E+ E++E EE E E V H ++ Y + K SRS
Sbjct: 131 ERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSP 190
Query: 273 -----EALAVDGAGKPGAEEAQDPEGK----GEQEHSQQKEEEEEMAVVPQGLFRGGKSG 323
E + KP EE + + S++K E + G SG
Sbjct: 191 PRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG------SG 244
Query: 324 ELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLS 375
E+EEE +E E S E + E+ E +EEEE+ +S + S
Sbjct: 245 SEEEEEEEEEEEEEGS---------TSEESEEEEEEEEEEEEETGSNSEEAS 287
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 60.8 bits (146), Expect = 2e-09
Identities = 67/294 (22%), Positives = 122/294 (41%), Gaps = 33/294 (11%)
Query: 100 FEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQ 159
+ ++L+ +++ KE E E E+ KE ++ ++ A P +
Sbjct: 328 YTEQLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAK 387
Query: 160 ESKAEGNNQAPGEEEEEEEEATNTH--PPASLPSQKYPGP---------------QAEGD 202
+G + +E T++H PP L +Q++P P Q D
Sbjct: 388 VPYGKGPSF-------NQERGTSSHLPPPPKLLAQQHPPPDRQAVPGRPGPFPSKQQVAD 440
Query: 203 SEGLSQGLVDREKGLSAEPGWQAKREEEEE---EEEEAEAGEEAVPEEEGPTVVLNPHPS 259
+ + + ++ +SA KR EEEE EE+ A E + + +L PS
Sbjct: 441 EDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPS 500
Query: 260 LGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRG 319
+EIR+ E E K E+ ++ E + ++E Q+KE+E E Q R
Sbjct: 501 P--EEIREREREKEREREKELEKE-QEQEREKEREKDRERQQEKEKELEKEQEKQ---RE 554
Query: 320 GKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMK 373
+ +++E+ L ++ E K KM + KE EK E EE+ + R+ +++
Sbjct: 555 MEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLE 608
Score = 42.0 bits (97), Expect = 0.001
Identities = 72/335 (21%), Positives = 129/335 (38%), Gaps = 52/335 (15%)
Query: 144 EATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD- 202
E G R + P P S+ E + E +E ++ N A + + G Q E D
Sbjct: 273 ETNKGLRGRG-PPPSWASEPERPSILSASELKELDKFDNLDAEAD---EGWAGAQMEVDY 328
Query: 203 ------SEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEE------------AEAGEEAV 244
S+ QG ++ S + G +A E ++E + A+ V
Sbjct: 329 TEQLNFSDDDEQGSNSPKENNSEDQGSKASENNENKKETDEVSNTKSSSQIPAQPSVAKV 388
Query: 245 P--------EEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGE 296
P +E G + L P P L + + + AV G +PG ++ +
Sbjct: 389 PYGKGPSFNQERGTSSHLPPPPKL----LAQQHPPPDRQAVPG--RPGPFPSKQQVADED 442
Query: 297 QEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWS-KMDQLAKELTAE 355
+ Q++ ++ E++ + + + E EE+R + E KR K+ L K+ + E
Sbjct: 443 EIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPE 502
Query: 356 KRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYP 415
+ E + E+E R+ ++ Q R R RE E L+
Sbjct: 503 EIREREREKEREREKELEKEQE-----------QEREKEREKDRERQQEKEKELEKE--- 548
Query: 416 EEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQ 450
+EK+ E ++ +++ELE E EL+K+ Q
Sbjct: 549 QEKQREMEKERKQEKEKELERQKEKEKELQKMKEQ 583
Score = 39.7 bits (91), Expect = 0.006
Identities = 78/382 (20%), Positives = 136/382 (35%), Gaps = 77/382 (20%)
Query: 121 VEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA 180
+++P +D+ E+RE KE K GE + + + +P + K + P + +
Sbjct: 1016 IKKPVLRDMKEEREQRKE--KEGEKAEKVTEKVVVKPEKTEKKDLPPPPPPPQPPAPIQP 1073
Query: 181 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGL------SAEPGWQAKREE----- 229
+ PP ++K+P + ++ SQ D EK L EP + ++
Sbjct: 1074 QSVPPPIQPEAEKFPSTETATLAQKPSQ---DTEKPLEPVSTVQVEPAVKTVNQQTMAAP 1130
Query: 230 --EEEEEEEAEAGEEAVPEEEGP--------TVVLNPH------------PSLGYKEIRK 267
+EE++ E ++ V E P L P P GY+ +
Sbjct: 1131 VVKEEKQPEKVISKDLVIERPRPDSRPAVKKESTLPPRTYWKEARERDWFPDQGYRGRGR 1190
Query: 268 GE----SRSEALAVDGAGKPGAEEAQD--------------PEGK-GEQEHSQQKEEEEE 308
GE RS + G G+ G +D P G ++E S+ + E +
Sbjct: 1191 GEYYSRGRSYRGSYGGRGRGGRGHTRDYPQYRDNKPRAEHIPSGPLRQREESETRSESSD 1250
Query: 309 MAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNR 368
VVP+ R + G + + + D SK +E E + +
Sbjct: 1251 FEVVPK---RRRQRGSETDTDSEIHESASDKDSLSKGKLPKREERPENKKPVKPHSSFKP 1307
Query: 369 DSSMKLSFR--ARAY---------GFRGPGPQLRRG----WRPSSREDSLEAGLPLQVR- 412
D+ +++ R + Y GF G RRG +R R+ P +R
Sbjct: 1308 DNHVRIDNRLLEKPYVRDDDKAKPGFLPKGEPTRRGRGGTFRRGGRDPGGRPSRPSTLRR 1367
Query: 413 -GYPEEKKEEEGSANRRPEDQE 433
Y + + S +PED E
Sbjct: 1368 PAYRDNQWNPRQSEVPKPEDGE 1389
Score = 38.9 bits (89), Expect = 0.010
Identities = 37/166 (22%), Positives = 71/166 (42%), Gaps = 14/166 (8%)
Query: 95 KKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKR--EDSKEA----------EKS 142
K+ EDE+ + + + Q+E+ AVE + E+R E+ ++A EK
Sbjct: 435 KQQVADEDEIWK--QRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKL 492
Query: 143 GEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD 202
G P+ + E +E + E + E+E+E E+ +K + E
Sbjct: 493 GILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQ 552
Query: 203 SEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEE 248
E + ++EK L + + + ++ +E+E+E E +E EE
Sbjct: 553 REMEKERKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEE 598
Score = 38.9 bits (89), Expect = 0.010
Identities = 34/131 (25%), Positives = 55/131 (41%), Gaps = 3/131 (2%)
Query: 56 CFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQA 115
C E L+ + L IL Q +E+++ + +ER + +K E E + + Q
Sbjct: 481 CAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQE 540
Query: 116 ELKEAVEEPSSKDVMEK-REDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEE 174
+ KE +E + MEK R+ KE E + Q + E QE + E + EE
Sbjct: 541 KEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKE--QEKECELEKEREKLEE 598
Query: 175 EEEEEATNTHP 185
+ E N P
Sbjct: 599 KIEPREPNLEP 609
Score = 35.4 bits (80), Expect = 0.11
Identities = 38/174 (21%), Positives = 72/174 (41%), Gaps = 13/174 (7%)
Query: 164 EGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGW 223
+G A +E+ EEE+ P P+Q PG A + + ++G + G
Sbjct: 80 DGTGWASKQEQHEEEKT-----PEVPPAQPKPGVAAPPEVAPAPKSWASNKQGGQGD-GI 133
Query: 224 QAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKP 283
Q + ++E AG++ E+E P PSL + +A AG P
Sbjct: 134 QVNSQFQQEFPSLQAAGDQEKKEKETNDDNYGPGPSLRPPNVACWRDGGKA-----AGSP 188
Query: 284 GAEEAQDPEGKGEQEHSQQKEEEEE-MAVVPQGLFRGGKSGELEQEEERLSKEW 336
+ + QD + G+ E + E+ + + VV + + G +L ++ L+ ++
Sbjct: 189 SSSD-QDEKLPGQDESTAGTSEQNDILKVVEKRIACGPPQAKLNGQQAALASQY 241
Score = 30.4 bits (67), Expect = 3.5
Identities = 26/96 (27%), Positives = 42/96 (43%), Gaps = 8/96 (8%)
Query: 108 LENQSSQAELKEAVEEPS-SKDVMEKRE--DSKEAEKSGEATDGARPQALPEPMQESKAE 164
L NQ+S + E E S S D E+RE + K A+ + + LP + +K
Sbjct: 1483 LSNQNSSDQANEEWETASESSDFNERRERDEKKNADLNAQTVVKVGENVLPPKREIAKRS 1542
Query: 165 GNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAE 200
++Q P + + N PP S + + GP+ E
Sbjct: 1543 FSSQRP---VDRQNRRGNNGPPKS--GRNFSGPRNE 1573
>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
exchanger), member 1 [Homo sapiens]
Length = 1099
Score = 60.5 bits (145), Expect = 3e-09
Identities = 59/247 (23%), Positives = 105/247 (42%), Gaps = 58/247 (23%)
Query: 122 EEPSSKDVMEKREDSKEAEKSGEATDGARPQAL---PEPMQESKAEGNNQAPGEEEEEEE 178
+E S + + + +AE E + A+ A+ P P+ + K + G+E+ E
Sbjct: 691 KEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKENPGGQEDVAEA 750
Query: 179 EATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKRE-----EEEEE 233
E+T P EG++ G +G + + G +P + + E EE E+
Sbjct: 751 ESTGEMPGE------------EGETAG--EGETEEKSGGETQPEGEGETETQGKGEECED 796
Query: 234 EEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAV--------------DG 279
E EAE + E+EG H G + +GE+ S+ L+ DG
Sbjct: 797 ENEAEGKGDNEGEDEGEI-----HAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDG 851
Query: 280 AGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEER-----LSK 334
G G + ++ E + EQE +++EE+EE + E E+EEE+ LS
Sbjct: 852 GGSDGGDSEEEEEEEEEQEEEEEEEEQEE------------EEEEEEEEEEKGNEEPLSL 899
Query: 335 EWEDSKR 341
+W ++++
Sbjct: 900 DWPETRQ 906
Score = 57.8 bits (138), Expect = 2e-08
Identities = 64/229 (27%), Positives = 94/229 (41%), Gaps = 42/229 (18%)
Query: 163 AEGNNQAPGEEEEEEEEATNTHPPASLPSQKY---PGPQAEGDSEGLSQGLVDREKGLSA 219
A QA E + EEEE PA LP+ P P +GD + G +E A
Sbjct: 700 ARAQPQAKAESKPEEEE------PAKLPAVTVTPAPVPDIKGDQKENPGG---QEDVAEA 750
Query: 220 EPGWQAKREEEE---EEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALA 276
E + EE E E E E ++G E PE EG T + G E + E+ +E
Sbjct: 751 ESTGEMPGEEGETAGEGETEEKSGGETQPEGEGET------ETQGKGEECEDENEAEGKG 804
Query: 277 VDGAGKPGAEEAQDPEGKGEQEHSQQKE---------EEEEMAVVPQGLFRGGKSGELEQ 327
+ G A+D E KG + ++ +E + +E V G GG S E E+
Sbjct: 805 DNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEE 864
Query: 328 EEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSF 376
EEE +E E+ ++ E+ E +EEEE + + L +
Sbjct: 865 EEEEQEEEEEEEEQ------------EEEEEEEEEEEEKGNEEPLSLDW 901
Score = 49.3 bits (116), Expect = 7e-06
Identities = 60/224 (26%), Positives = 86/224 (38%), Gaps = 61/224 (27%)
Query: 67 LSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDE----LSEVLENQSSQAELK-EAV 121
L LR L KE ++ +L Q K S E+E L V + ++K +
Sbjct: 679 LDPLREVRLAKEKEEESLNQGARAQPQAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQK 738
Query: 122 EEPSSKDVMEKREDS-----KEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEE 176
E P ++ + + E + +E E +GE + +P E + E Q GEE E+
Sbjct: 739 ENPGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQP--EGEGETETQGKGEECED 796
Query: 177 EEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKG-------------LSAEPGW 223
E EA + +GD+EG +G + E G LSAE
Sbjct: 797 ENEA-----------------EGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHG 839
Query: 224 QAKR-------------------EEEEEEEEEAEAGEEAVPEEE 248
+AK EEEEEE+EE E EE EEE
Sbjct: 840 EAKNDEKGVEDGGGSDGGDSEEEEEEEEEQEEEEEEEEQEEEEE 883
Score = 44.3 bits (103), Expect = 2e-04
Identities = 64/259 (24%), Positives = 100/259 (38%), Gaps = 62/259 (23%)
Query: 200 EGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPS 259
E + E L+QG A+P QAK E + EEEE A+ V P + + +
Sbjct: 690 EKEEESLNQGA-------RAQP--QAKAESKPEEEEPAKLPAVTVTPAPVPDIKGDQKEN 740
Query: 260 LGYKE-IRKGESRSEALAVDG--AGKPGAEEAQ----DPEGKGEQEHSQQKEE-EEEMAV 311
G +E + + ES E +G AG+ EE PEG+GE E + EE E+E
Sbjct: 741 PGGQEDVAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEA 800
Query: 312 VPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSS 371
+G G GE+ E+ + +++ ++EL+AE E + +E+ D
Sbjct: 801 EGKGDNEGEDEGEIHAEDGEMKGNEGETE--------SQELSAENHGEAKNDEKGVEDGG 852
Query: 372 MKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPED 431
G G G EE++EEE E+
Sbjct: 853 ----------GSDG---------------------------GDSEEEEEEEEEQEEEEEE 875
Query: 432 QELESLSAIEAELEKVAHQ 450
+E E E E E+ ++
Sbjct: 876 EEQEEEEEEEEEEEEKGNE 894
Score = 42.4 bits (98), Expect = 9e-04
Identities = 39/162 (24%), Positives = 66/162 (40%), Gaps = 17/162 (10%)
Query: 94 QKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQA 153
QK++ G +++++E E E E ++ EK + E GE + +
Sbjct: 737 QKENPGGQEDVAEAESTGEMPGEEGETAGEGETE---EKSGGETQPEGEGETETQGKGEE 793
Query: 154 LPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGP---QAEGDSEGLSQG- 209
E E++ +G+N+ E E E+ SQ+ +A+ D +G+ G
Sbjct: 794 C-EDENEAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGG 852
Query: 210 ---------LVDREKGLSAEPGWQAKREEEEEEEEEAEAGEE 242
+ E+ E + + EEEEEEEEE E G E
Sbjct: 853 GSDGGDSEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEEKGNE 894
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 60.5 bits (145), Expect = 3e-09
Identities = 63/253 (24%), Positives = 94/253 (37%), Gaps = 58/253 (22%)
Query: 118 KEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEE 177
+EA E PS+ +K + + A E+ A P P P Q P E +
Sbjct: 512 EEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDA 571
Query: 178 EEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKG--LSAEPGWQAKREEEEEEEE 235
A T PPA P P A G DRE+ L AE QA+ + E EE+E
Sbjct: 572 --AVLTSPPAPAPPVTPSKPMA---------GTTDREEATRLLAEKRRQAREQREREEQE 620
Query: 236 EAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKG 295
E R R E LA ++ E +
Sbjct: 621 RRLQAE------------------------RDKRMREEQLA------------REAEARA 644
Query: 296 EQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAE 355
E+E ++ EE+E K+ ++E+ERL K+ E+++ S+ + + L E
Sbjct: 645 EREAEARRREEQEARE---------KAQAEQEEQERLQKQKEEAEARSREEAERQRLERE 695
Query: 356 KRLEGQEEEEDNR 368
K + QE+E R
Sbjct: 696 KHFQQQEQERQER 708
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/162 (24%), Positives = 74/162 (45%), Gaps = 29/162 (17%)
Query: 71 RHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVM 130
R Q +E + + + A+ + +++KH +++ E Q + L+E ++ +V
Sbjct: 671 RLQKQKEEAEARSREEAERQRLEREKHFQQQEQ-----ERQERRKRLEEIMKRTRKSEVS 725
Query: 131 E--KREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEE--EEEEATNTHPP 186
E +++DSKEA +G + PEP++ +A ++PG ++E ++EE P
Sbjct: 726 ETKQKQDSKEANANGSS---------PEPVKAVEA----RSPGLQKEAVQKEEPIPQEPQ 772
Query: 187 ASLPSQKYPGPQAEG-------DSEGLSQGLVDREKGLSAEP 221
SLPS++ P G G S +K LS P
Sbjct: 773 WSLPSKELPASLVNGLQPLPAHQENGFSTNGPSGDKSLSRTP 814
Score = 41.6 bits (96), Expect = 0.002
Identities = 36/164 (21%), Positives = 69/164 (42%), Gaps = 19/164 (11%)
Query: 70 LRHQNLLKELQDLALQGAKERAHQQ---KKHSGFEDELSEVLENQSSQAELKEAVEEPSS 126
+R + L +E + A + A+ R ++ ++ + E E E L+ Q +AE + E
Sbjct: 631 MREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQERLQKQKEEAEARSREEAERQ 690
Query: 127 KDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHP- 185
+ EK +E E+ R + L E M+ ++ ++ +++ +E A + P
Sbjct: 691 RLEREKHFQQQEQERQ------ERRKRLEEIMKRTRKSEVSETKQKQDSKEANANGSSPE 744
Query: 186 PASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREE 229
P + PG Q E V +E+ + EP W +E
Sbjct: 745 PVKAVEARSPGLQKEA---------VQKEEPIPQEPQWSLPSKE 779
Score = 34.7 bits (78), Expect = 0.18
Identities = 47/205 (22%), Positives = 85/205 (41%), Gaps = 37/205 (18%)
Query: 102 DELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQES 161
+E + +L + QA + EE + E+ + +E + + EA AR + E +
Sbjct: 597 EEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAE--ARAEREAEARRRE 654
Query: 162 KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEP 221
+ E +A E+EE+E L QK ++E S+ +R++ L E
Sbjct: 655 EQEAREKAQAEQEEQER----------LQKQK-------EEAEARSREEAERQR-LEREK 696
Query: 222 GWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAG 281
+Q + +E +E + E + + E E ++ + EA A +
Sbjct: 697 HFQQQEQERQERRKRLEEIMKRTRKSE-------------VSETKQKQDSKEANANGSSP 743
Query: 282 KP-GAEEAQDPEGKGEQEHSQQKEE 305
+P A EA+ P G Q+ + QKEE
Sbjct: 744 EPVKAVEARSP---GLQKEAVQKEE 765
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 59.7 bits (143), Expect = 5e-09
Identities = 71/329 (21%), Positives = 132/329 (40%), Gaps = 33/329 (10%)
Query: 48 SPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEV 107
SP E + E+ S ++ + + + A KE A +K E +
Sbjct: 704 SPEKAKSPVKEEAKSPEKAKSPVKEE---AKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760
Query: 108 LENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNN 167
+++ ++ KE P+ K + + KE KS E + P +E +
Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV 820
Query: 168 QAPGEEEEEEEEATNTHPPASLPSQKYPG-PQAEGDSEGLSQGLVDREKGLSAEPGWQAK 226
++P +EEE+ +E PP +K P P+ E + + +E + +P + K
Sbjct: 821 KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKE---APKPKVEEK 877
Query: 227 REEEEEEEEEAEA---GEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKP 283
+E E+ +E++ EEA +++ PT + KE K + ++E +P
Sbjct: 878 KEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEV----AKKEP 933
Query: 284 GAEEAQDPEGKGEQEHS--QQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKR 341
+A++P E++ + ++K+ +EE A P E++ + +K ED K
Sbjct: 934 DDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKP------------EEKPKTEAKAKEDDKT 981
Query: 342 WSKMDQLAKELTAEKRLEGQEEEEDNRDS 370
SK K AEK D +DS
Sbjct: 982 LSKEPSKPKAEKAEK-----SSSTDQKDS 1005
Score = 55.1 bits (131), Expect = 1e-07
Identities = 84/405 (20%), Positives = 153/405 (37%), Gaps = 39/405 (9%)
Query: 53 SQECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQS 112
S+E + + E+ I+ Q E + + +E + K+ G E+E E E +
Sbjct: 440 SEEKIKVVEKSEKETVIVEEQT---EETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 113 SQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGE 172
+ E K E E KEA+ + + +A +E+K+ ++P +
Sbjct: 497 GEEETKSPPAE-------EAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEK 549
Query: 173 EEEEEEEATNTHPPASLPSQKYPGPQAEGDS--EGLSQGLVDREKGLSAEPGWQAKREEE 230
+ +E + P A P ++ AE S + S + + A+ +AK +
Sbjct: 550 AKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVK 609
Query: 231 EEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQD 290
EE + AEA E + P V +P E K ++ EA + + A P EEA+
Sbjct: 610 EEAKSPAEAKSPVKEEAKSPAEVKSP-------EKAKSPTKEEAKSPEKAKSPEKEEAKS 662
Query: 291 PEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKS-GELEQEEERLSKEWEDSKRWSKMDQLA 349
PE ++ K E+ + V K+ +++E + K K +K + A
Sbjct: 663 PEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKA 722
Query: 350 K-----ELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLE 404
K E ++ + +EE K +A+ + P + P+ E
Sbjct: 723 KSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAK-----TPAKEEARSP 777
Query: 405 AGLPLQVRGYPEEKK---EEEGSANRRPEDQELESLSAIEAELEK 446
A +PE+ K +EE + + + E A E E+ K
Sbjct: 778 AD------KFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPK 816
Score = 45.8 bits (107), Expect = 8e-05
Identities = 60/238 (25%), Positives = 88/238 (36%), Gaps = 33/238 (13%)
Query: 130 MEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASL 189
++ E K EKS + T Q + E E + EEE +EEE
Sbjct: 438 VKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEE----- 492
Query: 190 PSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEG 249
+AEG E + +A P +AK +EE + AEA E +
Sbjct: 493 --------EAEGGEEETKSPPAEE----AASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
Query: 250 PTVVLNPH-------------PSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDP-EGKG 295
P V +P P E + +S +E + + A P EEA+ P E K
Sbjct: 541 PAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKS 600
Query: 296 -EQEHSQQKEEEEEMAVVPQGLFRGGKS-GELEQEEERLSKEWEDSKRWSKMDQLAKE 351
E+ S KEE + A + KS E++ E+ S E++K K KE
Sbjct: 601 PEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKE 658
Score = 30.0 bits (66), Expect = 4.6
Identities = 32/146 (21%), Positives = 59/146 (40%), Gaps = 12/146 (8%)
Query: 294 KGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELT 353
K E++ ++ E+E +V + + E+ +EEE+ +KE E + +E
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKE---------EEGG 489
Query: 354 AEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRG 413
E+ EG EEE + + S A + P + + + + EA P +V+
Sbjct: 490 EEEEAEGGEEETKSPPAEEAASPEKEA---KSPVKEEAKSPAEAKSPEKEEAKSPAEVKS 546
Query: 414 YPEEKKEEEGSANRRPEDQELESLSA 439
+ K + A PE + E A
Sbjct: 547 PEKAKSPAKEEAKSPPEAKSPEKEEA 572
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 59.3 bits (142), Expect = 7e-09
Identities = 63/282 (22%), Positives = 110/282 (39%), Gaps = 47/282 (16%)
Query: 87 AKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEAT 146
+KE ++ + + S++LE+ S + K + E + ++ +E +
Sbjct: 239 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 298
Query: 147 DGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGL 206
+R L +P ++SK G++Q +E +EE+ N P+S SQ
Sbjct: 299 SNSRDTGLSQPRRDSK--GDSQEDSKENLSQEESQNVDGPSSESSQ-------------- 342
Query: 207 SQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIR 266
E LS+ +E +E+ EE V E G NP P+ Y E +
Sbjct: 343 -------EANLSS-------------QENSSESQEEVVSESRGD----NPDPTTSYVEDQ 378
Query: 267 KGESRSE---ALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEE--EEEMAVVPQGLFRGGK 321
+ SE + + + EE D E S++ E E+E + +GL
Sbjct: 379 EDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSS 438
Query: 322 SGELEQEEERLSKEWEDSK--RWSKMDQLAKELTAEKRLEGQ 361
S E + EE ++ DS+ SK D + E + +GQ
Sbjct: 439 SAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 480
Score = 40.8 bits (94), Expect = 0.003
Identities = 72/334 (21%), Positives = 115/334 (34%), Gaps = 53/334 (15%)
Query: 122 EEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEAT 181
+E S + E + + + S + T + E +SK EG + E EE
Sbjct: 137 DEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 196
Query: 182 NTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGE 241
+ +S G +E D EG+ D + + +E G + +E E E
Sbjct: 197 GSDGESS------HGDGSELDDEGMQS---DDPESIRSERGNSRMNSAGMKSKESGENSE 247
Query: 242 EAVPEEEGPTVVLNPHPS---LGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQE 298
+A ++ G + +L HPS I + + RSE D E+
Sbjct: 248 QANTQDSGGSQLLE-HPSRKIFRKSRISEEDDRSEL---------------DDNNTMEEV 291
Query: 299 HSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRL 358
S E R K E +E LS+E + +D + E + E L
Sbjct: 292 KSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN-----VDGPSSESSQEANL 346
Query: 359 EGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGW------RPSSREDSLEAGLPLQVR 412
QE ++++ + S RG P + SS EDS L
Sbjct: 347 SSQENSSESQEEVVSES--------RGDNPDPTTSYVEDQEDSDSSEEDSSHT-LSHSKS 397
Query: 413 GYPEEKKEEEGS-----ANRRPEDQELESLSAIE 441
EE+ + E S + PE E E+ S+ E
Sbjct: 398 ESREEQADSESSESLNFSEESPESPEDENSSSQE 431
Score = 37.0 bits (84), Expect = 0.037
Identities = 68/348 (19%), Positives = 131/348 (37%), Gaps = 43/348 (12%)
Query: 133 REDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQ 192
R + E+E S E G QA P++ S++ ++ EE+ E+ + +T L S
Sbjct: 21 RYQNNESEDS-EEWKGHLAQAPTPPLESSESSEGSKVSSEEQANEDPSDSTQSEEGLGSD 79
Query: 193 KY---------------------------PGPQAEGDSEGLSQGLVDREKGLSAEPGWQA 225
+ G GD + G DR++G ++ G
Sbjct: 80 DHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDS-GPGPKDRQEGGNSRLGSDE 138
Query: 226 KREEE-EEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVD---GAG 281
++ + EE A G+++ + + L+ + K G+S E+ + + G G
Sbjct: 139 DSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKP-EGGDSTQESESEEHWVGGG 197
Query: 282 KPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKE--WEDS 339
G E+ +G + Q ++ E + +G R +G +E S++ +DS
Sbjct: 198 SDG--ESSHGDGSELDDEGMQSDDPESIR-SERGNSRMNSAGMKSKESGENSEQANTQDS 254
Query: 340 KRWSKMDQLAKELTAEKRL---EGQEEEEDNRDSSMKLSFRARAYGFRGPG-PQLRRGWR 395
++ ++++ + R+ + + E +DN S R G Q RR +
Sbjct: 255 GGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSK 314
Query: 396 PSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAE 443
S+EDS E + + E AN ++ ES + +E
Sbjct: 315 GDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSE 362
>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
Length = 497
Score = 59.3 bits (142), Expect = 7e-09
Identities = 63/282 (22%), Positives = 110/282 (39%), Gaps = 47/282 (16%)
Query: 87 AKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEAT 146
+KE ++ + + S++LE+ S + K + E + ++ +E +
Sbjct: 223 SKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTEN 282
Query: 147 DGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGL 206
+R L +P ++SK G++Q +E +EE+ N P+S SQ
Sbjct: 283 SNSRDTGLSQPRRDSK--GDSQEDSKENLSQEESQNVDGPSSESSQ-------------- 326
Query: 207 SQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIR 266
E LS+ +E +E+ EE V E G NP P+ Y E +
Sbjct: 327 -------EANLSS-------------QENSSESQEEVVSESRGD----NPDPTTSYVEDQ 362
Query: 267 KGESRSE---ALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEE--EEEMAVVPQGLFRGGK 321
+ SE + + + EE D E S++ E E+E + +GL
Sbjct: 363 EDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSS 422
Query: 322 SGELEQEEERLSKEWEDSK--RWSKMDQLAKELTAEKRLEGQ 361
S E + EE ++ DS+ SK D + E + +GQ
Sbjct: 423 SAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ 464
Score = 40.8 bits (94), Expect = 0.003
Identities = 72/334 (21%), Positives = 115/334 (34%), Gaps = 53/334 (15%)
Query: 122 EEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEAT 181
+E S + E + + + S + T + E +SK EG + E EE
Sbjct: 121 DEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWVGG 180
Query: 182 NTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGE 241
+ +S G +E D EG+ D + + +E G + +E E E
Sbjct: 181 GSDGESS------HGDGSELDDEGMQS---DDPESIRSERGNSRMNSAGMKSKESGENSE 231
Query: 242 EAVPEEEGPTVVLNPHPS---LGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQE 298
+A ++ G + +L HPS I + + RSE D E+
Sbjct: 232 QANTQDSGGSQLLE-HPSRKIFRKSRISEEDDRSEL---------------DDNNTMEEV 275
Query: 299 HSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRL 358
S E R K E +E LS+E + +D + E + E L
Sbjct: 276 KSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN-----VDGPSSESSQEANL 330
Query: 359 EGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGW------RPSSREDSLEAGLPLQVR 412
QE ++++ + S RG P + SS EDS L
Sbjct: 331 SSQENSSESQEEVVSES--------RGDNPDPTTSYVEDQEDSDSSEEDSSHT-LSHSKS 381
Query: 413 GYPEEKKEEEGS-----ANRRPEDQELESLSAIE 441
EE+ + E S + PE E E+ S+ E
Sbjct: 382 ESREEQADSESSESLNFSEESPESPEDENSSSQE 415
>gi|207113164 Treacher Collins-Franceschetti syndrome 1 isoform f
[Homo sapiens]
Length = 1412
Score = 59.3 bits (142), Expect = 7e-09
Identities = 84/407 (20%), Positives = 149/407 (36%), Gaps = 43/407 (10%)
Query: 54 QECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSS 113
Q+CF L +L I H EL G K +A + + +S+ + S
Sbjct: 36 QKCF--LAQPVTLLDIYTHWQQTSEL------GRKRKAEEDAALQAKKTRVSDPISTSES 87
Query: 114 QAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEE 173
E +EA + E +K + LP M+E KA+ + G+
Sbjct: 88 SEEEEEA-----------EAETAKATPRLASTNSSVLGADLPSSMKE-KAKAETEKAGKT 135
Query: 174 EEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREK-----GLSAEPGWQAKRE 228
A+L S K P AE + + E G +A+PG + +
Sbjct: 136 GNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ 195
Query: 229 EEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEA 288
+ E+ + + +E E + +L + + G+ + A GK GA +
Sbjct: 196 ADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPA----PPGKAGAVAS 251
Query: 289 QDPEGKGEQE---HSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKM 345
Q GK E++ S++ + EE + L + SG+ Q + E ++ +
Sbjct: 252 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 311
Query: 346 DQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGF---RGPGPQLRRGWRPSSREDS 402
K A + + + EED++ SS + A G PQ+R P ++E
Sbjct: 312 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP-AKESP 370
Query: 403 LEAGLPLQVR-------GYPEEKKEEEGSANRRPEDQELESLSAIEA 442
+ P R K+EE+ ++ D + E+L+A+ A
Sbjct: 371 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 417
Score = 52.4 bits (124), Expect = 9e-07
Identities = 77/314 (24%), Positives = 126/314 (40%), Gaps = 47/314 (14%)
Query: 88 KERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAE---KSGE 144
K A + +G +E SE +SS +E E P++K +++ + K ++ S
Sbjct: 245 KAGAVASQTKAGKPEEDSESSSEESSDSE----EETPAAKALLQAKASGKTSQVGAASAP 300
Query: 145 ATDGARPQALPEP----------MQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKY 194
A + R A P P Q K E ++Q+ EE + EEEA P + PS K
Sbjct: 301 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEA----PAQAKPSGKA 356
Query: 195 P------GPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEE-EEAEAGEEAVPEE 247
P P E +G + R+ G +A K+EE+ EE+++ EA+
Sbjct: 357 PQVRAASAPAKESPRKGAAPA-PPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM 415
Query: 248 E-------GPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEA---QDPEGKGEQ 297
G + + P ++G + KG V G P A+ +D E E
Sbjct: 416 NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKV-GPATPSAQVGKWEEDSESSSE- 473
Query: 298 EHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKR 357
E S + E AV P + G + Q + S + K +A ++ AEK
Sbjct: 474 ESSDSSDGEVPTAVAPA---QEKSLGNILQAKPTSSPAKGPPQ---KAGPVAVQVKAEKP 527
Query: 358 LEGQEEEEDNRDSS 371
++ E E++ DS+
Sbjct: 528 MDNSESSEESSDSA 541
Score = 37.7 bits (86), Expect = 0.022
Identities = 42/196 (21%), Positives = 72/196 (36%), Gaps = 30/196 (15%)
Query: 131 EKREDSKEAEKSGEATDGA-------------RPQALPEPMQESKAEGNNQAPGE----- 172
EK+EDS+ +E+ ++ + A + +A P + A+G APG+
Sbjct: 680 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 739
Query: 173 EEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEE 232
+ ++ + PP P + + + + + + EEE +
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799
Query: 233 EEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPE 292
EEEAE + P G T + + + RKG A GK G AQ
Sbjct: 800 SEEEAETLAQVKP--SGKTHQIRAALAPAKESPRKG------AAPTPPGKTGPSAAQ--- 848
Query: 293 GKGEQEHSQQKEEEEE 308
G+Q+ S EE +
Sbjct: 849 -AGKQDDSGSSSEESD 863
Score = 37.4 bits (85), Expect = 0.029
Identities = 76/344 (22%), Positives = 127/344 (36%), Gaps = 42/344 (12%)
Query: 116 ELKEAVEEPSSKDVMEKREDSKE-AEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEE 174
E+++A + P S D E DS +E+ GE GA+ G + E
Sbjct: 1055 EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAK--------SAHTLVGPTPSRTETL 1106
Query: 175 EEEEEATNTHPPASLPSQK-YPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEE 233
EE A ++ PSQ G G + SQ K L + P + +++
Sbjct: 1107 VEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPK-LDSSPSVSSTLAAKDDP 1165
Query: 234 EEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGES-RSEALAVDGAGKPGAEEAQDPE 292
+ + +EA P++ + P G KE G + + GAG P A
Sbjct: 1166 DGK----QEAKPQQAAGML----SPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS 1217
Query: 293 G-----KGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQ 347
G+ + + + + V L + ++ +E K WE KR DQ
Sbjct: 1218 NITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQ 1277
Query: 348 LA---------KELTAEKRLEGQEEEEDNRDSSMKLSFRARAYG----FRGPGPQLRRGW 394
A K+L A + E E +S + R +A G +G G +G
Sbjct: 1278 PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGA 1337
Query: 395 RPSSREDSLEAGLPLQVRG---YPEEKKEEEGSANRRPEDQELE 435
+ E+ L+ G+ G P+ KKE++ S R+ + ++ E
Sbjct: 1338 K-DEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1380
Score = 37.4 bits (85), Expect = 0.029
Identities = 53/275 (19%), Positives = 108/275 (39%), Gaps = 54/275 (19%)
Query: 125 SSKDVMEKREDSKEAEKSG---------EATDGARPQALPEPMQESKAEGNNQA------ 169
++KD + ++++K + +G EA G PQ +P K GN QA
Sbjct: 1160 AAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKP---KKGAGNPQASTLALQ 1216
Query: 170 ----------PGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSA 219
P E + +A+ L Q+ + E +G R++ LS
Sbjct: 1217 SNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERK-KVVDTTKESSRKGWESRKRKLSG 1275
Query: 220 E-PGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVD 278
+ P + R +++++ E GE +V E+ T KG+++ + + D
Sbjct: 1276 DQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTT-------------SKGKAKRDKASGD 1322
Query: 279 GAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGG--KSGELEQEEERLSKEW 336
++ +GKG K+E EE G GG + + ++E+++ K
Sbjct: 1323 ---------VKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRK 1373
Query: 337 EDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSS 371
+D ++ K + K T + Q++++ + ++
Sbjct: 1374 KDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTA 1408
Score = 30.0 bits (66), Expect = 4.6
Identities = 40/179 (22%), Positives = 60/179 (33%), Gaps = 29/179 (16%)
Query: 143 GEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD 202
G+ T P + + KAE + EEE + E P S K +A
Sbjct: 659 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANP- 717
Query: 203 SEGLSQGLVDREKGLSAEPG------WQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNP 256
+ KG + PG QAK+ + + + + GP V
Sbjct: 718 ----AAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV--- 770
Query: 257 HPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQG 315
PS+G +A+A + G EE G E+E ++E E V P G
Sbjct: 771 -PSVG-----------KAVATAAQAQTGPEE---DSGSSEEESDSEEEAETLAQVKPSG 814
>gi|57164975 Treacher Collins-Franceschetti syndrome 1 isoform b
[Homo sapiens]
Length = 1411
Score = 59.3 bits (142), Expect = 7e-09
Identities = 84/407 (20%), Positives = 149/407 (36%), Gaps = 43/407 (10%)
Query: 54 QECFETLRGDERILSILRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSS 113
Q+CF L +L I H EL G K +A + + +S+ + S
Sbjct: 36 QKCF--LAQPVTLLDIYTHWQQTSEL------GRKRKAEEDAALQAKKTRVSDPISTSES 87
Query: 114 QAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEE 173
E +EA + E +K + LP M+E KA+ + G+
Sbjct: 88 SEEEEEA-----------EAETAKATPRLASTNSSVLGADLPSSMKE-KAKAETEKAGKT 135
Query: 174 EEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREK-----GLSAEPGWQAKRE 228
A+L S K P AE + + E G +A+PG + +
Sbjct: 136 GNSMPHPATGKTVANLLSGKSPRKSAEPSANTTLVSETEEEGSVPAFGAAAKPGMVSAGQ 195
Query: 229 EEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEA 288
+ E+ + + +E E + +L + + G+ + A GK GA +
Sbjct: 196 ADSSSEDTSSSSDETDVEVKASEKILQVRAASAPAKGTPGKGATPA----PPGKAGAVAS 251
Query: 289 QDPEGKGEQE---HSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKM 345
Q GK E++ S++ + EE + L + SG+ Q + E ++ +
Sbjct: 252 QTKAGKPEEDSESSSEESSDSEEETPAAKALLQAKASGKTSQVGAASAPAKESPRKGAAP 311
Query: 346 DQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGF---RGPGPQLRRGWRPSSREDS 402
K A + + + EED++ SS + A G PQ+R P ++E
Sbjct: 312 APPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEAPAQAKPSGKAPQVRAASAP-AKESP 370
Query: 403 LEAGLPLQVR-------GYPEEKKEEEGSANRRPEDQELESLSAIEA 442
+ P R K+EE+ ++ D + E+L+A+ A
Sbjct: 371 RKGAAPAPPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAMNA 417
Score = 52.4 bits (124), Expect = 9e-07
Identities = 77/314 (24%), Positives = 126/314 (40%), Gaps = 47/314 (14%)
Query: 88 KERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAE---KSGE 144
K A + +G +E SE +SS +E E P++K +++ + K ++ S
Sbjct: 245 KAGAVASQTKAGKPEEDSESSSEESSDSE----EETPAAKALLQAKASGKTSQVGAASAP 300
Query: 145 ATDGARPQALPEP----------MQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKY 194
A + R A P P Q K E ++Q+ EE + EEEA P + PS K
Sbjct: 301 AKESPRKGAAPAPPGKTGPAVAKAQAGKREEDSQSSSEESDSEEEA----PAQAKPSGKA 356
Query: 195 P------GPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEE-EEAEAGEEAVPEE 247
P P E +G + R+ G +A K+EE+ EE+++ EA+
Sbjct: 357 PQVRAASAPAKESPRKGAAPA-PPRKTGPAAAQVQVGKQEEDSRSSSEESDSDREALAAM 415
Query: 248 E-------GPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEA---QDPEGKGEQ 297
G + + P ++G + KG V G P A+ +D E E
Sbjct: 416 NAAQVKPLGKSPQVKPASTMGMGPLGKGAGPVPPGKV-GPATPSAQVGKWEEDSESSSE- 473
Query: 298 EHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKR 357
E S + E AV P + G + Q + S + K +A ++ AEK
Sbjct: 474 ESSDSSDGEVPTAVAPA---QEKSLGNILQAKPTSSPAKGPPQ---KAGPVAVQVKAEKP 527
Query: 358 LEGQEEEEDNRDSS 371
++ E E++ DS+
Sbjct: 528 MDNSESSEESSDSA 541
Score = 38.1 bits (87), Expect = 0.017
Identities = 76/344 (22%), Positives = 128/344 (37%), Gaps = 43/344 (12%)
Query: 116 ELKEAVEEPSSKDVMEKREDSKE-AEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEE 174
E+++A + P S D E DS +E+ GE GA+ + G + E
Sbjct: 1055 EVQQATKAPESSDDSEDSSDSSSGSEEDGEGPQGAK---------SAHTLGPTPSRTETL 1105
Query: 175 EEEEEATNTHPPASLPSQK-YPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEE 233
EE A ++ PSQ G G + SQ K L + P + +++
Sbjct: 1106 VEETAAESSEDDVVAPSQSLLSGYMTPGLTPANSQASKATPK-LDSSPSVSSTLAAKDDP 1164
Query: 234 EEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGES-RSEALAVDGAGKPGAEEAQDPE 292
+ + +EA P++ + P G KE G + + GAG P A
Sbjct: 1165 DGK----QEAKPQQAAGML----SPKTGGKEAASGTTPQKSRKPKKGAGNPQASTLALQS 1216
Query: 293 G-----KGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQ 347
G+ + + + + V L + ++ +E K WE KR DQ
Sbjct: 1217 NITQCLLGQPWPLNEAQVQASVVKVLTELLEQERKKVVDTTKESSRKGWESRKRKLSGDQ 1276
Query: 348 LA---------KELTAEKRLEGQEEEEDNRDSSMKLSFRARAYG----FRGPGPQLRRGW 394
A K+L A + E E +S + R +A G +G G +G
Sbjct: 1277 PAARTPRSKKKKKLGAGEGGEASVSPEKTSTTSKGKAKRDKASGDVKEKKGKGSLGSQGA 1336
Query: 395 RPSSREDSLEAGLPLQVRG---YPEEKKEEEGSANRRPEDQELE 435
+ E+ L+ G+ G P+ KKE++ S R+ + ++ E
Sbjct: 1337 K-DEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRKKDKEKKE 1379
Score = 37.7 bits (86), Expect = 0.022
Identities = 42/196 (21%), Positives = 72/196 (36%), Gaps = 30/196 (15%)
Query: 131 EKREDSKEAEKSGEATDGA-------------RPQALPEPMQESKAEGNNQAPGE----- 172
EK+EDS+ +E+ ++ + A + +A P + A+G APG+
Sbjct: 680 EKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANPAAARAPSAKGTISAPGKVVTAA 739
Query: 173 EEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEE 232
+ ++ + PP P + + + + + + EEE +
Sbjct: 740 AQAKQRSPSKVKPPVRNPQNSTVLARGPASVPSVGKAVATAAQAQTGPEEDSGSSEEESD 799
Query: 233 EEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPE 292
EEEAE + P G T + + + RKG A GK G AQ
Sbjct: 800 SEEEAETLAQVKP--SGKTHQIRAALAPAKESPRKG------AAPTPPGKTGPSAAQ--- 848
Query: 293 GKGEQEHSQQKEEEEE 308
G+Q+ S EE +
Sbjct: 849 -AGKQDDSGSSSEESD 863
Score = 37.4 bits (85), Expect = 0.029
Identities = 53/275 (19%), Positives = 108/275 (39%), Gaps = 54/275 (19%)
Query: 125 SSKDVMEKREDSKEAEKSG---------EATDGARPQALPEPMQESKAEGNNQA------ 169
++KD + ++++K + +G EA G PQ +P K GN QA
Sbjct: 1159 AAKDDPDGKQEAKPQQAAGMLSPKTGGKEAASGTTPQKSRKP---KKGAGNPQASTLALQ 1215
Query: 170 ----------PGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSA 219
P E + +A+ L Q+ + E +G R++ LS
Sbjct: 1216 SNITQCLLGQPWPLNEAQVQASVVKVLTELLEQERK-KVVDTTKESSRKGWESRKRKLSG 1274
Query: 220 E-PGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVD 278
+ P + R +++++ E GE +V E+ T KG+++ + + D
Sbjct: 1275 DQPAARTPRSKKKKKLGAGEGGEASVSPEKTSTT-------------SKGKAKRDKASGD 1321
Query: 279 GAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGG--KSGELEQEEERLSKEW 336
++ +GKG K+E EE G GG + + ++E+++ K
Sbjct: 1322 ---------VKEKKGKGSLGSQGAKDEPEEELQKGMGTVEGGDQSNPKSKKEKKKSDKRK 1372
Query: 337 EDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSS 371
+D ++ K + K T + Q++++ + ++
Sbjct: 1373 KDKEKKEKKKKAKKASTKDSESPSQKKKKKKKKTA 1407
Score = 30.0 bits (66), Expect = 4.6
Identities = 40/179 (22%), Positives = 60/179 (33%), Gaps = 29/179 (16%)
Query: 143 GEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD 202
G+ T P + + KAE + EEE + E P S K +A
Sbjct: 659 GQGTAPVLPGKTGPTVTQVKAEKQEDSESSEEESDSEEAAASPAQVKTSVKKTQAKANP- 717
Query: 203 SEGLSQGLVDREKGLSAEPG------WQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNP 256
+ KG + PG QAK+ + + + + GP V
Sbjct: 718 ----AAARAPSAKGTISAPGKVVTAAAQAKQRSPSKVKPPVRNPQNSTVLARGPASV--- 770
Query: 257 HPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQG 315
PS+G +A+A + G EE G E+E ++E E V P G
Sbjct: 771 -PSVG-----------KAVATAAQAQTGPEE---DSGSSEEESDSEEEAETLAQVKPSG 814
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 57.8 bits (138), Expect = 2e-08
Identities = 50/229 (21%), Positives = 107/229 (46%), Gaps = 7/229 (3%)
Query: 27 KGDTEVMKCIVEVISDTLSKPSPMPVSQECFE--TLRGDERILSILRHQNLLKELQDLAL 84
K +++M+ ++ + +++ V +E + G+ +I + + E+++ +
Sbjct: 46 KTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENI 105
Query: 85 QGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEK-REDSKEAEKSG 143
+ A E+ ++K+ E + +E + + + + E E +D EK ED KE +
Sbjct: 106 EDATEKGGEKKEAVAAEVK-NEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGN 164
Query: 144 EATDGARPQALPEPMQESKAEGNN-QAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD 202
E + A+ + + ++ K G + + GE+E+EEE+ T K G + EG
Sbjct: 165 EKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGK 224
Query: 203 SEGLSQGLVDREKGLSAEPG--WQAKREEEEEEEEEAEAGEEAVPEEEG 249
+ + +RE G E G +A +E+E+ +EEE E+ + E++G
Sbjct: 225 DVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDG 273
Score = 52.4 bits (124), Expect = 9e-07
Identities = 56/244 (22%), Positives = 106/244 (43%), Gaps = 25/244 (10%)
Query: 74 NLLKELQDLALQGAKERAHQQKKHSGFEDEL----SEVLENQSSQAELKEAVEEPSSKDV 129
++++E D + Q E + + + +++ E +S+ E+ E V+E + +D
Sbjct: 50 DMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVE-VKEENIEDA 108
Query: 130 MEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEE-EEATNTHPPAS 188
EK + KEA + + + E E K E + E+ EE+ +E N +
Sbjct: 109 TEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGE 168
Query: 189 LPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEE----EEAEAGEEAV 244
+K G + E +G G +EKG + ++EEE+ +E +E E G+E
Sbjct: 169 DAKEKEDGKKGE---DGKGNGEDGKEKG-------EDEKEEEDRKETGDGKENEDGKEKG 218
Query: 245 PEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKE 304
++EG V + ++ R+ E + AGK + ++ EGK E E +
Sbjct: 219 DKKEGKDVKVKED-----EKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDG 273
Query: 305 EEEE 308
++EE
Sbjct: 274 KKEE 277
Score = 39.7 bits (91), Expect = 0.006
Identities = 54/248 (21%), Positives = 97/248 (39%), Gaps = 38/248 (15%)
Query: 124 PSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNT 183
P + +V KR S K+ + + E+K E + E + EA T
Sbjct: 29 PVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKIT 88
Query: 184 HPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEA 243
PAS +K E + E ++ ++++ ++AE K EEE+++E+E + EE
Sbjct: 89 EAPAS---EKEIVEVKEENIEDATEKGGEKKEAVAAE----VKNEEEDQKEDEEDQNEE- 140
Query: 244 VPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQK 303
KGE+ E + G E+ ++ + E+ ++
Sbjct: 141 -----------------------KGEAGKE-----DKDEKGEEDGKEDKNGNEKGEDAKE 172
Query: 304 EEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSK--RWSKMDQLAKELTAEKRLEGQ 361
+E+ + +G GK +++EE KE D K K KE K E +
Sbjct: 173 KEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDE 232
Query: 362 EEEEDNRD 369
+E ED ++
Sbjct: 233 KEREDGKE 240
Score = 30.4 bits (67), Expect = 3.5
Identities = 23/93 (24%), Positives = 41/93 (44%), Gaps = 5/93 (5%)
Query: 85 QGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGE 144
+G E+ + +K +G E E+ + + KE + +D E RED KE E E
Sbjct: 192 KGEDEKEEEDRKETGDGKEN----EDGKEKGDKKEGKDVKVKEDEKE-REDGKEDEGGNE 246
Query: 145 ATDGARPQALPEPMQESKAEGNNQAPGEEEEEE 177
G + L E + + + + G++EE +
Sbjct: 247 EEAGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQ 279
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 57.4 bits (137), Expect = 3e-08
Identities = 95/448 (21%), Positives = 167/448 (37%), Gaps = 85/448 (18%)
Query: 89 ERAHQQKKHSGFEDEL-SEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATD 147
ER + ++ E L +E + Q + + +EA E + E+ +E E G+ TD
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 148 GARPQALPE-PMQESKAEGNN-QAPGEEE------------------------EEEEEAT 181
A P +E+K N Q G++E ++E + T
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Query: 182 NTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGL------------------SAEPGW 223
T SLPS++ AE ++ + R++ AE
Sbjct: 125 ITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENK 184
Query: 224 QAKREEEEEEEEEAEAG-----------EEAVPEEEGPTVVLNPHPSLGYKEIRKGESRS 272
+ +E+EEEEEE+ + G EE E + TVV+ SL +I E +
Sbjct: 185 KEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVM----SLKNGQISSEEPKQ 240
Query: 273 EALAVDGAGKPGAEEAQDPEGK--GEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEE- 329
E G+ + E + E K E E ++ + EE E Q + +E EE
Sbjct: 241 EEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEK 300
Query: 330 ----ERLSKEWEDSKRWSKMDQLAKE----------LTAEKRLEGQEEEEDNRDSSMKL- 374
ER +E E+ +R + ++ A E AE+R +EEE+ + ++
Sbjct: 301 AAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIK 360
Query: 375 -------SFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANR 427
R RA ++ R E+ A +++G E+K E N
Sbjct: 361 EEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNE 420
Query: 428 RPEDQELESLSAIEAELEKVAHQLQALR 455
+ ++ + ++ + E+ ++QA R
Sbjct: 421 KKAQEDKLQTAVLKKQGEEKGTKVQAKR 448
Score = 50.1 bits (118), Expect = 4e-06
Identities = 71/323 (21%), Positives = 138/323 (42%), Gaps = 43/323 (13%)
Query: 80 QDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEA 139
Q+ + A+ER +++ +E + E + AE ++ ++E + E++ +E
Sbjct: 304 QERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEE 363
Query: 140 EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATN-THPPASLPSQKYPGP- 197
+++ E AR + +E KA+ Q ++ EE++ A T QK G
Sbjct: 364 KRAAEERQRARAE------EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKW 417
Query: 198 -QAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEE---EEAEAGEEAVPEEEGPTVV 253
+ E Q V +++G QAKRE+ +E++ ++ E +E + +++ P
Sbjct: 418 VNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEE 477
Query: 254 LNPHPSL--GYKEIRK--GESRSEAL--------------AVDGAGKPGA---------E 286
+ G+ E++ GE + L +VD GA E
Sbjct: 478 VKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLE 537
Query: 287 EAQDPEGKGEQEHSQQ-KEEEEEMAVVPQGLF--RGGKSGELEQEEERLSKEWEDSK-RW 342
E + G+ E E ++ K++++E A+ + L R + LE+EE+R +E D K R
Sbjct: 538 ELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLRE 597
Query: 343 SKMDQLAKELTAEKRLEGQEEEE 365
+ + KE +R E E+ +
Sbjct: 598 EEEKRRLKEEIERRRAEAAEKRQ 620
Score = 49.3 bits (116), Expect = 7e-06
Identities = 72/309 (23%), Positives = 133/309 (43%), Gaps = 33/309 (10%)
Query: 78 ELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEE-----PSSKDVMEK 132
E ++ A +ER +++ E+E E Q + E K A EE K E+
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355
Query: 133 REDSKEAEK-SGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA-TNTHPPASLP 190
R+ KE EK + E AR + +E KA+ Q ++ EE++ A T
Sbjct: 356 RQRIKEEEKRAAEERQRARAE------EEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV 409
Query: 191 SQKYPGP--QAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEE---EEAEAGEEAVP 245
QK G + E Q V +++G QAKRE+ +E++ ++ E +E +
Sbjct: 410 EQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 469
Query: 246 EEEGPTVVLNP--HPSLGYKEIR--KGESRSEAL--AVDGAGKPGAE---EAQDPEGKGE 296
+++ P + G+ E++ GE + L + +PG + ++ EG +
Sbjct: 470 KDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQ 529
Query: 297 QEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEK 356
E ++ EE +G + +L+Q+++ + E E+ K+ K ++ K L E+
Sbjct: 530 VEAGKRLEELRRR----RGETESEEFEKLKQKQQEAALELEELKK--KREERRKVLEEEE 583
Query: 357 RLEGQEEEE 365
+ QEE +
Sbjct: 584 QRRKQEEAD 592
>gi|24415404 MDN1, midasin homolog [Homo sapiens]
Length = 5596
Score = 57.4 bits (137), Expect = 3e-08
Identities = 60/268 (22%), Positives = 109/268 (40%), Gaps = 33/268 (12%)
Query: 81 DLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAE 140
D L G + +++ +E ++ + S+ K+ + + + + ++D KE +
Sbjct: 4775 DERLWGDDDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEK 4834
Query: 141 KSGEATDGARPQ-ALPEPMQESKAEGNNQAP---GEEEEEEEEATNTHPPASLPSQKYPG 196
+ EA DG + + + E + E + N P +E+ E EA + +L S+ G
Sbjct: 4835 EEAEADDGGQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNG 4894
Query: 197 PQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNP 256
+ + EG + ++ + E +A E EE E E + E P+E
Sbjct: 4895 GEDTDNEEGEEENPLEIK-----EKPEEAGHEAEERGETETDQNESQSPQE--------- 4940
Query: 257 HPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGL 316
P G E K E E GA + AQ PE E++ +E+++E
Sbjct: 4941 -PEEGPSEDDKAEGEEE--MDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADE----- 4992
Query: 317 FRGGKSGELEQ------EEERLSKEWED 338
GG++G +Q EEER + E+
Sbjct: 4993 -EGGENGPADQGFQPQEEEEREDSDTEE 5019
Score = 55.1 bits (131), Expect = 1e-07
Identities = 51/195 (26%), Positives = 88/195 (45%), Gaps = 25/195 (12%)
Query: 119 EAVEEPSSKDVMEKREDS-KEAEKSGEA-TDGARPQALPEP----MQESKAEGNNQAP-G 171
E EE + ++ EK E++ EAE+ GE TD Q+ EP ++ KAEG + G
Sbjct: 4901 EEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTG 4960
Query: 172 EEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEE 231
++++ + A + + Q E D EG G D+ G+Q + EEE
Sbjct: 4961 ADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEEGGENGPADQ--------GFQPQEEEER 5012
Query: 232 EEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDP 291
E+ + E EA+ +E H S G + ++ ++A+ + GA P E+ ++
Sbjct: 5013 EDSDTEEQVPEALERKE--------HASCGQTGVENMQN-TQAMELAGAA-PEKEQGKEE 5062
Query: 292 EGKGEQEHSQQKEEE 306
G G + +Q + E
Sbjct: 5063 HGSGAADANQAEGHE 5077
Score = 36.2 bits (82), Expect = 0.064
Identities = 61/303 (20%), Positives = 115/303 (37%), Gaps = 58/303 (19%)
Query: 85 QGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVME------KREDSKE 138
QG + + ++++ S E+++ E LE + + + VE + ME ++E KE
Sbjct: 5002 QGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGAAPEKEQGKE 5061
Query: 139 AEKSGEA----TDGARPQALPEPMQESKAEGNNQA----PGEEEEEEEEA---------- 180
SG A +G + + + N Q+ PG+ + E
Sbjct: 5062 EHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNERVHKRL 5121
Query: 181 ----TNTHPPASLPSQKYPGPQAEGDS-EGLSQG----------LVDREKGLSAEPGWQA 225
T++H P+Q+ + D+ E + QG + +E+ SA+ +
Sbjct: 5122 RTVDTDSHAEQG-PAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKD 5180
Query: 226 KREEE---------EEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALA 276
+ EEE E+EE +A E+ PEE + LG+ E+ E + +
Sbjct: 5181 QEEEEIEDTLMDTEEQEEFKAADVEQLKPEE----IKSGTTAPLGFDEM---EVEIQTVK 5233
Query: 277 VDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRG--GKSGELEQEEERLSK 334
+ P ++A + E S++ + +F+ EL QE ER +
Sbjct: 5234 TEEDQDPRTDKAHKETENEKPERSRESTIHTAHQFLMDTIFQPFLKDVNELRQELERQLE 5293
Query: 335 EWE 337
W+
Sbjct: 5294 MWQ 5296
Score = 35.0 bits (79), Expect = 0.14
Identities = 42/189 (22%), Positives = 76/189 (40%), Gaps = 41/189 (21%)
Query: 262 YKEIRKGESRSEALAVDGAG---KPGAEEAQDPEGKGEQ-----EHSQQKEEEE------ 307
+ E GE +E +G G G ++ D G EQ + Q+K++E+
Sbjct: 4660 FMEDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSD 4719
Query: 308 --------EMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRW------SKMDQLAKELT 353
EM+ G G+ E E+++E+ E D + + D+L + L
Sbjct: 4720 IKGEDNAIEMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDERLW 4779
Query: 354 AEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRG 413
+ E EEEEDN+ GPG +++D+L++G + +
Sbjct: 4780 GDDDEEEDEEEEDNKTEE------------TGPGMD-EEDSELVAKDDNLDSGNSNKDKS 4826
Query: 414 YPEEKKEEE 422
++K+E+E
Sbjct: 4827 QQDKKEEKE 4835
>gi|23503317 coiled-coil domain containing 96 [Homo sapiens]
Length = 555
Score = 57.0 bits (136), Expect = 3e-08
Identities = 64/227 (28%), Positives = 93/227 (40%), Gaps = 27/227 (11%)
Query: 140 EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQA 199
+ GE DG A P ++ S + PGE E E EE A+ QA
Sbjct: 10 DPGGEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEE--EEEEQAASQGGTAADEQA 67
Query: 200 EGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPS 259
E +GL+ E+G EPG A+ + E EE E A E A PE P
Sbjct: 68 EA-PKGLTAAEAAGEEG-PGEPGRPAEPQPEPEEPAEVGAEEPAQPE-----------PG 114
Query: 260 LGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRG 319
G +E+ + E+ +E L GK +A P + ++E + E E V
Sbjct: 115 AGPEEL-EAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERV-------- 165
Query: 320 GKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEED 366
GE E+++E ++ +SK + AK KRL G++E ED
Sbjct: 166 --EGE-EEDKEETQRDGAESKERDGEGRPAKSQEEGKRLYGRDEFED 209
Score = 56.6 bits (135), Expect = 5e-08
Identities = 50/183 (27%), Positives = 75/183 (40%), Gaps = 22/183 (12%)
Query: 196 GPQAEGDSEGLSQGLVDREKG--LSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVV 253
G +G+S + G S EPG EEEEEE+ A G A E+
Sbjct: 13 GEGGDGESLAARPSKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQA----- 67
Query: 254 LNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVP 313
E KG + +EA +G G+PG PE + E ++ + E P
Sbjct: 68 ----------EAPKGLTAAEAAGEEGPGEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGP 117
Query: 314 QGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAE---KRLEGQEE--EEDNR 368
+ L + ELEQ E ++ S +++D+ E +R+EG+EE EE R
Sbjct: 118 EELEAEAGAEELEQAAEGKEVRFQASLPLTRIDEEEAAAAPEAETERVEGEEEDKEETQR 177
Query: 369 DSS 371
D +
Sbjct: 178 DGA 180
Score = 42.7 bits (99), Expect = 7e-04
Identities = 91/400 (22%), Positives = 145/400 (36%), Gaps = 82/400 (20%)
Query: 115 AELKEAVEEPSSKDVMEKREDSKEAEKSGEATDG---ARPQA-LPEPMQESKAEGNNQAP 170
+++K + P+S + E + +E E+ A+ G A QA P+ + ++A G + P
Sbjct: 26 SKIKASSGPPTSPEPGELESEPEEEEEEQAASQGGTAADEQAEAPKGLTAAEAAGE-EGP 84
Query: 171 GEEEEEEEEATNTHPPASL----PSQKYPGP-----QAEGDSEGLSQGLVDREKGLSAEP 221
GE E PA + P+Q PG +AE +E L Q +E A
Sbjct: 85 GEPGRPAEPQPEPEEPAEVGAEEPAQPEPGAGPEELEAEAGAEELEQAAEGKEVRFQASL 144
Query: 222 GWQAKREEEEEEEEEAEA----GEEAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAV 277
EEE EAE GEE EE KE R GE R
Sbjct: 145 PLTRIDEEEAAAAPEAETERVEGEEEDKEE-------TQRDGAESKE-RDGEGRPAKSQE 196
Query: 278 DGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLF-------------------- 317
+G G +E +D E E + Q+++ ++ + L
Sbjct: 197 EGKRLYGRDEFEDLEWSEEVQKLQEQQLRSDLLDQYRSLLVERNRSQRYNLYLQHKIFEA 256
Query: 318 --------------RGGKSGELEQEE---------ERLSKEWEDSKRWSKMDQLAKELTA 354
RG ++ E+E+ E L K+ D +W + +
Sbjct: 257 LRRKKGLEAAEVADRGAEAEAPEKEQAYLRHLGMLEELKKQQADDLQWYHQELGQLKRQC 316
Query: 355 EKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGY 414
+++L + E+E R ++K +A G ++R G + + RE L
Sbjct: 317 QEKLT-RVEKEWRRFQALKKQVVMQAMG----SCRMRGGRQAALREVEQIQAL------- 364
Query: 415 PEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQAL 454
E+KKE+E SA R Q +SL E + Q L
Sbjct: 365 -EDKKEKEMSAVRLENIQLKQSLVHFETRMRTQEDLTQGL 403
>gi|115648142 centrosomal protein 164kDa [Homo sapiens]
Length = 1460
Score = 56.6 bits (135), Expect = 5e-08
Identities = 74/300 (24%), Positives = 123/300 (41%), Gaps = 33/300 (11%)
Query: 93 QQKKHSGFEDELSEVLENQS-SQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGA-- 149
Q K+ G E+ LS L ++ +Q+ + E E + + KEAE+ GE + +
Sbjct: 460 QSKQSKGLEERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLS 519
Query: 150 -----------RPQALPEPMQESKAEGNNQAPGEEEEEEEE---ATNTHPPAS------- 188
P A E +E ++ PG+EE E+ E A + PP S
Sbjct: 520 LQLSLQREQAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTE 579
Query: 189 --LPSQKYPGPQAEGDSEGLSQGLVDREKGL--SAEPGWQAKREEEEEEEEEAEAGEEAV 244
P ++ + E ++Q L ++ L S + Q RE+ +EEEE
Sbjct: 580 PVAPPEQLSEAALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEEEEEILRLHQQ 639
Query: 245 PEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKE 304
E+ ++ ++ +E R E S+ L+ A + +A + + + EQE S QK
Sbjct: 640 KEQSLSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQADEDQIRAEQEASLQKL 699
Query: 305 EEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEE 364
EE + Q R + Q E+L +E E S+ K +Q A EK L+ E+
Sbjct: 700 REELES--QQKAERASLEQKNRQMLEQLKEEIEASE---KSEQAALNAAKEKALQQLREQ 754
Score = 44.3 bits (103), Expect = 2e-04
Identities = 96/453 (21%), Positives = 178/453 (39%), Gaps = 72/453 (15%)
Query: 42 DTLSKPSPMPVSQECFETLRGDERILSILRHQNLLKELQDLALQGAKE---RAHQQKKHS 98
+ LS+ + + + + L D+R L + Q +++L++ Q +E R HQQK+ S
Sbjct: 585 EQLSEAALKAMEEAVAQVLEQDQRHL-LESKQEKMQQLREKLCQEEEEEILRLHQQKEQS 643
Query: 99 ----------GFEDELSEVLENQSSQAE-LKEAVEEPSSKDVMEKREDSKEAEKSGEATD 147
E+E + + E +S + L+ V+ + D ED AE+
Sbjct: 644 LSSLRERLQKAIEEEEARMREEESQRLSWLRAQVQSSTQAD-----EDQIRAEQEASLQK 698
Query: 148 GARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPG-----PQAEGD 202
+ + + E N+ E+ +EE EA+ A+L + K Q EG+
Sbjct: 699 LREELESQQKAERASLEQKNRQMLEQLKEEIEASEKSEQAALNAAKEKALQQLREQLEGE 758
Query: 203 SEGLSQGLVDREKGLSAE-----PGWQAKREEE----EEEEEEAEAGEEAVPEEEGPTVV 253
+ + + EK SAE +AK E +++ +EA+ EEA ++
Sbjct: 759 RK---EAVATLEKEHSAELERLCSSLEAKHREVVSSLQKKIQEAQQKEEAQLQK------ 809
Query: 254 LNPHPSLGYKEIRKGESRSEALAVDGA-GKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVV 312
LG E R + + E+ Q+ EG+ E+ + KEE +++
Sbjct: 810 -----CLGQVEHRVHQKSYHVAGYEHELSSLLREKRQEVEGEHERRLDKMKEEHQQVMAK 864
Query: 313 PQGLF-------RGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEG---QE 362
+ + R G L E ERL + E + +Q KRLE +
Sbjct: 865 AREQYEAEERKQRAELLGHLTGELERLQRAHERELETVRQEQ-------HKRLEDLRRRH 917
Query: 363 EEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEE 422
E++ + ++L RA + L + RE + QV K EE
Sbjct: 918 REQERKLQDLELDLETRAKDVKARLALLEVQEETARREKQQLLDVQRQV----ALKSEEA 973
Query: 423 GSANRRPEDQELESLSAIEA--ELEKVAHQLQA 453
+ +++ E+ + E +++ +L ++ +LQA
Sbjct: 974 TATHQQLEEAQKEHTHLLQSNQQLREILDELQA 1006
Score = 40.8 bits (94), Expect = 0.003
Identities = 85/394 (21%), Positives = 164/394 (41%), Gaps = 63/394 (15%)
Query: 95 KKHSGFEDELSEVLENQSSQAELKEAV---------EEPSSKDVMEKREDSKEAEKSGEA 145
++ SG L E EN+ S+ ++ + EP+ E ED+ +A + G
Sbjct: 301 RQGSGARPGLPEKEENEKSEPKICRNLVTPKADPTGSEPAKASEKEAPEDTVDAGEEGSR 360
Query: 146 TDGARPQALPEPMQESKA--EGNNQAPGEEE--EEEEEATNTHPPASLPSQKYPGPQAEG 201
R +A EP +++ A EG++ A E E E +E + AS P + + G G
Sbjct: 361 ----REEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDP-KSFHGLDF-G 414
Query: 202 DSEGLSQGLVDREKGLSAEPGWQAKREEEE---EEEEEAEAGEEAVPEEEGPTVVLNPHP 258
+S+ L+D + LS G ++ ++ E+++++++ ++ + ++ + P
Sbjct: 415 FRSRISEHLLDVDV-LSPVLGGACRQAQQPLGIEDKDDSQSSQDELQSKQSKGLEERLSP 473
Query: 259 SLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFR 318
L ++E + +S +LA + E Q PEG+ E + +++ E+ ++
Sbjct: 474 PLPHEE--RAQSPPRSLATE------EEPPQGPEGQPEWKEAEELGEDSAASL------- 518
Query: 319 GGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDS-----SMK 373
S +L + E+ ++ + A+EL GQEE ED + +
Sbjct: 519 ---SLQLSLQREQAPSPPAACEKGKEQHSQAEELGP-----GQEEAEDPEEKVAVSPTPP 570
Query: 374 LSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKE-----------EE 422
+S R+ P QL + E+++ L R E K+E EE
Sbjct: 571 VSPEVRSTEPVAPPEQLSEA-ALKAMEEAVAQVLEQDQRHLLESKQEKMQQLREKLCQEE 629
Query: 423 GSANRRPEDQELESLSAIEAELEKVAHQLQALRR 456
R Q+ +SLS++ L+K + +A R
Sbjct: 630 EEEILRLHQQKEQSLSSLRERLQKAIEEEEARMR 663
Score = 33.5 bits (75), Expect = 0.41
Identities = 86/381 (22%), Positives = 132/381 (34%), Gaps = 92/381 (24%)
Query: 131 EKREDSKEAEKSGEATDGARPQALPEPMQESKA-----EGNNQAPGEEEEEEEEATNTHP 185
EK++ S +++ +G T +P + S A +G+ PG E+EE E +
Sbjct: 265 EKKDVSLDSDAAGPPTP-CKPSSPGADSSLSSAVGKGRQGSGARPGLPEKEENEKSEPKI 323
Query: 186 PASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVP 245
+L + K D G +EP AK E+E E+ +AGEE
Sbjct: 324 CRNLVTPK-------ADPTG-------------SEP---AKASEKEAPEDTVDAGEEGSR 360
Query: 246 EEEGPTV-----------VLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAE-------- 286
EE + L E K S+++A D G +
Sbjct: 361 REEAAKEPKKKASALEEGSSDASQELEISEHMKEPQLSDSIASDPKSFHGLDFGFRSRIS 420
Query: 287 ------------------EAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQE 328
+AQ P G +++ SQ ++E + S + +
Sbjct: 421 EHLLDVDVLSPVLGGACRQAQQPLGIEDKDDSQSSQDELQ-------------SKQSKGL 467
Query: 329 EERLSKEWEDSKR-WSKMDQLAKELTAEKRLEGQ----EEEEDNRDSSMKLSFRARAYGF 383
EERLS +R S LA E + EGQ E EE DS+ LS +
Sbjct: 468 EERLSPPLPHEERAQSPPRSLATEEEPPQGPEGQPEWKEAEELGEDSAASLSLQLSLQRE 527
Query: 384 RGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELE-------- 435
+ P P + E G + PEEK + PE + E
Sbjct: 528 QAPSPPAACEKGKEQHSQAEELGPGQEEAEDPEEKVAVSPTPPVSPEVRSTEPVAPPEQL 587
Query: 436 SLSAIEAELEKVAHQLQALRR 456
S +A++A E VA L+ +R
Sbjct: 588 SEAALKAMEEAVAQVLEQDQR 608
>gi|157738619 smoothelin-like 1 [Homo sapiens]
Length = 512
Score = 56.6 bits (135), Expect = 5e-08
Identities = 64/242 (26%), Positives = 110/242 (45%), Gaps = 29/242 (11%)
Query: 85 QGAKERAHQQKKHSGFEDELSEVLENQSSQA-ELK-EAVEEPSSKDVME---KREDSKEA 139
+G + +Q+K ED +S L+ +++ E+K E+ E K+ E K+ED ++
Sbjct: 62 EGPPTESGKQEKAPA-EDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKE 120
Query: 140 EKS--GEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGP 197
E + + G + + EP + + E + ++ EE+E + A + P P
Sbjct: 121 ETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEP 180
Query: 198 QA---EGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVL 254
+A E D++ SQ + K S EP +A EE + E ++A +EA E + P
Sbjct: 181 KATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEAKAEPKEPD--- 237
Query: 255 NPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPE---GKGEQEHSQQKEEEEEMAV 311
G +E + G ++ EA A K AE+A++ E EQE +KE E V
Sbjct: 238 ------GKEEAKHG-AKEEADA-----KEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGV 285
Query: 312 VP 313
+P
Sbjct: 286 IP 287
Score = 47.4 bits (111), Expect = 3e-05
Identities = 54/231 (23%), Positives = 85/231 (36%), Gaps = 27/231 (11%)
Query: 117 LKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEE 176
+ E S K ED AE GEA + E K E +A G+E+ E
Sbjct: 60 INEGPPTESGKQEKAPAEDGMSAELQGEANG----------LDEVKVESQREAGGKEDAE 109
Query: 177 EE--EATNTHPPASLPSQKYPGPQAEGDSEG----------LSQGLVDREKGLSAEPGWQ 224
E + ++ SQ+ G + E SE S+ EK E G +
Sbjct: 110 AELKKEDGEKEETTVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQK 169
Query: 225 AKREEEEEEEEEAEAGEE----AVPEEEGPTVVLNPHPS-LGYKEIRKGESRSEALAVDG 279
A + ++ E +A EE A EE G + P E K ES+ + +
Sbjct: 170 ADANDRDKPEPKATVEEEDAKTASQEETGQRKECSTEPKEKATDEEAKAESQKAVVEDEA 229
Query: 280 AGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEE 330
+P + ++ G +E + KEE E+ G + ++E+E E
Sbjct: 230 KAEPKEPDGKEEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPE 280
Score = 38.1 bits (87), Expect = 0.017
Identities = 33/126 (26%), Positives = 57/126 (45%), Gaps = 10/126 (7%)
Query: 83 ALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKS 142
A ++E Q+K+ S E E ++ ++AE ++AV E +K + KE +
Sbjct: 189 AKTASQEETGQRKECS---TEPKEKATDEEAKAESQKAVVEDEAK------AEPKEPDGK 239
Query: 143 GEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQA-EG 201
EA GA+ +A + E E +P EE+E++ E +PS P++ G
Sbjct: 240 EEAKHGAKEEADAKEEAEDAEEAEPGSPSEEQEQDVEKEPEGGAGVIPSSPEEWPESPTG 299
Query: 202 DSEGLS 207
+ LS
Sbjct: 300 EGHNLS 305
Score = 34.7 bits (78), Expect = 0.18
Identities = 53/265 (20%), Positives = 101/265 (38%), Gaps = 20/265 (7%)
Query: 195 PGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVL 254
PG E D ++ +++++G +E G + E A E G +
Sbjct: 3 PGAVGESDCSAEAREKMEQKEGKLSEDGTTVSPAADNPEMSGGGAPAEETKGTAGKAINE 62
Query: 255 NPHPSLGYKEIRKGESRSEAL---AVDGAGKPGAEEAQDPEGKGEQEHSQQKEE-EEEMA 310
P G +E E A +G + E ++ GK + E +KE+ E+E
Sbjct: 63 GPPTESGKQEKAPAEDGMSAELQGEANGLDEVKVESQREAGGKEDAEAELKKEDGEKEET 122
Query: 311 VVPQGLFRGGKS------GELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQE-- 362
V G K E E++E L+ E + ++ + ++ A R + +
Sbjct: 123 TVGSQEMTGRKEETKSEPKEAEEKESTLASEKQKAEEKEAKPESGQKADANDRDKPEPKA 182
Query: 363 --EEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEK-- 418
EEED + +S + + + + + ++ +S +A + + + P+E
Sbjct: 183 TVEEEDAKTASQEETGQRKECSTE----PKEKATDEEAKAESQKAVVEDEAKAEPKEPDG 238
Query: 419 KEEEGSANRRPEDQELESLSAIEAE 443
KEE + D + E+ A EAE
Sbjct: 239 KEEAKHGAKEEADAKEEAEDAEEAE 263
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 56.2 bits (134), Expect = 6e-08
Identities = 80/389 (20%), Positives = 161/389 (41%), Gaps = 42/389 (10%)
Query: 71 RHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVM 130
R + L+E + + ++ Q+K+ E EL E + Q +L+E E+ ++
Sbjct: 259 RQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQE-- 316
Query: 131 EKREDSKEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLP 190
EK + +E + E + + L E ++ + + EE E++ +
Sbjct: 317 EKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMR 376
Query: 191 SQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEE---------EEEEAEAGE 241
Q+ Q E E + + +REK + E + RE+EE+ E+EE E +
Sbjct: 377 EQEKMWEQEEKMQE--EERIREREKKMREEE--ETMREQEEKMQKQEENMWEQEEKEWQQ 432
Query: 242 EAVPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQ 301
+ +PE++ L + +E + E E D G E+ + K ++ Q
Sbjct: 433 QRLPEQKEK---LWEQEKMQEQEEKIWE--QEEKIRDQEEMWGQEKKMWRQEKMREQEDQ 487
Query: 302 QKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQ 361
E+EE+M Q ++ + + +++ERL ++ E + KM Q +++ EK+ + Q
Sbjct: 488 MWEQEEKMRDQEQKMW--DQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQ 545
Query: 362 EEEEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEE 421
E++ +++ M+ R R R + E+ + EEK +E
Sbjct: 546 EKKTWDQEEKMREEERMR-----------EREKKMREEEEMMRE---------QEEKMQE 585
Query: 422 EGSANRRPEDQELESLSAIEAELEKVAHQ 450
+ R E++ E ++ + EK+ Q
Sbjct: 586 QEEKMREQEEKMWEQEEKMQEQEEKMWEQ 614
Score = 52.8 bits (125), Expect = 7e-07
Identities = 71/391 (18%), Positives = 165/391 (42%), Gaps = 51/391 (13%)
Query: 80 QDLALQGAKERAHQQKKHSGFEDELSE---VLENQSSQAELKEAVEEPSSKDVMEKREDS 136
QD L+ +ER +Q+K E+++ E + E + E +E + E K M+K+E++
Sbjct: 364 QDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK--MQKQEEN 421
Query: 137 KEAEKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEE----------EEEEATNTHPP 186
++ E P+ + ++ K + + E+EE +E++
Sbjct: 422 MWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM 481
Query: 187 ASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAVPE 246
Q + + D E Q + D+E+ + + ++EE E+++ EE + E
Sbjct: 482 REQEDQMWEQEEKMRDQE---QKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMRE 538
Query: 247 EE----------GPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGE 296
E+ + + +E + E + + E+ ++ E K
Sbjct: 539 EKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMW 598
Query: 297 QEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERL-----------SKEWEDSKRWSKM 345
++ + +E+EE+M + ++ + +++++EE + K WE ++ +
Sbjct: 599 EQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQ 658
Query: 346 DQLAKELTAEKRLEGQEE---EEDNRDSSMKLSFRARAYGFRGPGPQLRRGWRPSSREDS 402
++ +E E++++GQEE E++ + + R + RG Q + W +E+
Sbjct: 659 EEKMRE--QEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRG---QEEKMW---GQEEK 710
Query: 403 LEAGLPLQVRGYPEEKKEEEGSANRRPEDQE 433
+ G ++ G E +++EE +++ + QE
Sbjct: 711 M-WGQEEKMWGQEEMREKEERIRDQKEKMQE 740
Score = 47.4 bits (111), Expect = 3e-05
Identities = 58/300 (19%), Positives = 126/300 (42%), Gaps = 36/300 (12%)
Query: 86 GAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEE---PSSKDVMEKREDSKEAEKS 142
G +++ +Q+K ED++ E E Q + EE + + EK E +E +K
Sbjct: 470 GQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKM 529
Query: 143 GEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGD 202
+ + R + + QE K + EEE E + ++
Sbjct: 530 WQQEEKMREEKKTQE-QEKKTWDQEEKMREEERMREREKKMREEEEMMREQ--------- 579
Query: 203 SEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAE-AGEEAVPEEEGPTVVLNPHPSLG 261
+ + ++E+ + + ++EE+ +E+EE EE + E+E + +
Sbjct: 580 ----EEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMW 635
Query: 262 YKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGK 321
+E + E + + + E+ ++ E K + + + +E+EE+M G+
Sbjct: 636 EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQ---------GQ 686
Query: 322 SGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEE----EEDNRDSSMKLSFR 377
++ ++EE++ ++ K W + +++ + E+++ GQEE EE RD K+ R
Sbjct: 687 EEKMREQEEKM--RGQEEKMWGQEEKMWGQ---EEKMWGQEEMREKEERIRDQKEKMQER 741
Score = 43.5 bits (101), Expect = 4e-04
Identities = 66/362 (18%), Positives = 145/362 (40%), Gaps = 23/362 (6%)
Query: 109 ENQSSQAELKEAV---EEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQESKAEG 165
E + AEL+E + E S+ + +E ++ E++ + L E M + E
Sbjct: 184 ELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEEL 243
Query: 166 NNQAPGEEEEEE----EEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEP 221
Q ++EE +E + Q+ + E + L ++EK L +
Sbjct: 244 REQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQK 303
Query: 222 GWQAKREEEEEEEEEAEAGEEAVPEEEGPTVVLNPHPSLGYKEIRKGESR-----SEALA 276
+ + E+ +E+EE+ EE + E+E K++R+ E +
Sbjct: 304 KLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWE 363
Query: 277 VDGAGKPGAEEAQDPEGKGEQEHSQQKEE---EEEMAVVPQGLFRGGKSGELEQEEERLS 333
D + E ++ E EQE Q+EE E E + + + +++++EE +
Sbjct: 364 QDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMW 423
Query: 334 KEWEDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPGPQLRRG 393
++ E + ++ + ++L ++++ QE+EE + K+ + +G Q ++
Sbjct: 424 EQEEKEWQQQRLPEQKEKLWEQEKM--QEQEEKIWEQEEKIRDQEEMWG------QEKKM 475
Query: 394 WRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLQA 453
WR + + + + +E+K + +D+ L E +K+ Q +
Sbjct: 476 WRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEK 535
Query: 454 LR 455
+R
Sbjct: 536 MR 537
Score = 43.1 bits (100), Expect = 5e-04
Identities = 43/207 (20%), Positives = 90/207 (43%), Gaps = 30/207 (14%)
Query: 58 ETLRGDERILSI---LRHQNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQ 114
E +R +ER+ +R + + Q+ +Q +E+ +Q++ ++E ++ E +
Sbjct: 554 EKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEE--KMQEQEEKM 611
Query: 115 AELKEAVEEPSSKDVMEKRED---------SKEAEKSGEATDGARPQALPEPMQESKAEG 165
E +E + E +D M+++E+ ++ EK E + R Q QE K +G
Sbjct: 612 WEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQG 671
Query: 166 NNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEP---- 221
+ E+EE+ + Q+ + E G + + +E+ + +
Sbjct: 672 QEEKMREQEEK------------MQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMW 719
Query: 222 GWQAKREEEEEEEEEAEAGEEAVPEEE 248
G + RE+EE ++ E +E +PE E
Sbjct: 720 GQEEMREKEERIRDQKEKMQERLPEHE 746
Score = 36.6 bits (83), Expect = 0.049
Identities = 53/247 (21%), Positives = 101/247 (40%), Gaps = 37/247 (14%)
Query: 230 EEEEEEEAEAGEEA-VPEEEGPTVVLNPHPSLGYKEIRKGESRSEALAVDGAGKPGAEEA 288
EE +++ AE E+ + E E + LN KE+++ R++ L EE
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLN------VKELKRKLERAKFLLPQVQTNTLQEEM 236
Query: 289 QDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSK-MDQ 347
E + ++ + +++EE+M + L + G++ ++EE++ ++ + + K + +
Sbjct: 237 WRQEEELREQEKKIRKQEEKMWRQEERLRE--QEGKMREQEEKMRRQEKRLREQEKELRE 294
Query: 348 LAKELTAEKRLEGQEE------------EEDNRDSSMKL------------SFRARAYGF 383
KEL +K+L QEE EE R+ K+ R +
Sbjct: 295 QEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKM 354
Query: 384 RGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAE 443
R Q R W R E + Q + + +E+K +E R E + E + +
Sbjct: 355 R---DQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQ 411
Query: 444 LEKVAHQ 450
EK+ Q
Sbjct: 412 EEKMQKQ 418
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 56.2 bits (134), Expect = 6e-08
Identities = 101/434 (23%), Positives = 169/434 (38%), Gaps = 85/434 (19%)
Query: 88 KERAHQQKKHSGFEDELSEVLENQSSQAE--LKEAVEEPSSKD------VMEKREDSKEA 139
K++ Q+ K F+D SE LE++ S+++ K VE S D + K+ K A
Sbjct: 96 KKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGK-A 154
Query: 140 EKSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQA 199
+KS + DG+ + ++ K + GE +E +E + + PGP
Sbjct: 155 QKSNKKWDGSEEDE--DNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNI 212
Query: 200 EGDSEGLSQGLVDR---EKGLSAEPGWQAKREEEE------EEEEEAEAG---------- 240
E +E + +K + + KR+EE+ +E+EE E G
Sbjct: 213 ESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKES 272
Query: 241 -----EEAVP-------------EEEGPTVVLNPHPSLGYKEIR-----KGESRS-EALA 276
EE V EE+ T + G K+ + KGE E
Sbjct: 273 QRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK 332
Query: 277 VDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEW 336
G K + Q+ K ++E +QK EEEE + L K E ++E+R K+
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392
Query: 337 EDSKRWSKMDQLAKELTAEKRLEGQEEEEDNRDSSMKLSFRARAYGFRGPG----PQLRR 392
++ +R ++ + K LT + Q E ++++KL +A G P P+ R
Sbjct: 393 KEKERKERLKKEGKLLT-----KSQREARARAEATLKL---LQAQGVEVPSKDSLPKKRP 444
Query: 393 GWRPSSRE------------DSLE--AGLPLQVRGYPEEKKEEEGSANRRPEDQELESLS 438
+ R+ +S+E A + + +G PE+++ ED E L
Sbjct: 445 IYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLD 504
Query: 439 AIEA-----ELEKV 447
EA E EKV
Sbjct: 505 DWEAMASDEETEKV 518
Score = 49.3 bits (116), Expect = 7e-06
Identities = 63/244 (25%), Positives = 105/244 (43%), Gaps = 33/244 (13%)
Query: 73 QNLLKELQDLALQGAKERAHQQKKHSGFEDELSEVLENQSSQAELK----EAVEEPSSKD 128
+ L +E ++ Q KER + KK + S+ ++A LK + VE PS
Sbjct: 380 ERLEQEKRERKKQKEKERKERLKKEGKLLTK-SQREARARAEATLKLLQAQGVEVPSKDS 438
Query: 129 VMEKR---EDSKEAE-----KSGEATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEA 180
+ +KR ED K + +S E ++ A E M++ E P E EEEE+
Sbjct: 439 LPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDT 498
Query: 181 TNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAG 240
+ A L + ++ ++E + V E + P + + EEEEEE+EE+E
Sbjct: 499 ED----AGLDD--WEAMASDEETEKVEGNKVHIE--VKENPEEEEEEEEEEEEDEESEEE 550
Query: 241 EEAVPEEEGPTVVLNPHPSLGYKEIRK-GESRSEALAVDGAGKPGAEEAQDPEGKGEQEH 299
EE E EG S G +E K + + +D KP E + D E + +
Sbjct: 551 EEEEGESEG---------SEGDEEDEKVSDEKDSGKTLD--KKPSKEMSSDSEYDSDDDR 599
Query: 300 SQQK 303
++++
Sbjct: 600 TKEE 603
Score = 47.8 bits (112), Expect = 2e-05
Identities = 76/337 (22%), Positives = 131/337 (38%), Gaps = 48/337 (14%)
Query: 76 LKELQDLALQGAKERAHQQKKHSGFEDELSE--------VLENQSSQAELKEAVEEPSSK 127
LKE ++L G K+++ Q++ FE+E + V+ +AE A E+ +
Sbjct: 253 LKEKEELET-GKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEG 311
Query: 128 DVMEKREDSKEAEKSGEATDGAR--PQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHP 185
D +K + K+ EK + + + +A + MQE+ A+ + ++ EEEE
Sbjct: 312 DKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE- 370
Query: 186 PASLPSQKYPGPQAEGDS-EGLSQGLVDREKGLSAEPGWQAKREEEEEEEEEAEAGEEAV 244
L +++ + E + E Q +R++ L E K + E EA
Sbjct: 371 --ELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQA 428
Query: 245 PEEEGPTVVLNPHP--------------SLGYKEIRKGESRSEALAVDGAGKPGAEEAQD 290
E P+ P L KE+ + A+ V G P EE
Sbjct: 429 QGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPP 488
Query: 291 PEGKGEQEHSQQ----------KEEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSK 340
P E+E ++ +EE E + ++ E E+EEE +E E+S
Sbjct: 489 PVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEES- 547
Query: 341 RWSKMDQLAKELTAEKRLEGQEEEE---DNRDSSMKL 374
++ +E + EG EE+E D +DS L
Sbjct: 548 -----EEEEEEEGESEGSEGDEEDEKVSDEKDSGKTL 579
Score = 47.8 bits (112), Expect = 2e-05
Identities = 63/300 (21%), Positives = 130/300 (43%), Gaps = 32/300 (10%)
Query: 85 QGAKERAHQQKKHSGFEDELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGE 144
+G K++ ++KK G ++E + + S+A +K E + E+R+ +E E+
Sbjct: 310 EGDKKKKDKKKK-KGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKR 368
Query: 145 ATDGARPQALPEPMQESKAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSE 204
+ + E +++ K E Q +E+E +E SQ+ +AE +
Sbjct: 369 LEELEAKRKEEERLEQEKRERKKQ----KEKERKERLKKEGKLLTKSQREARARAEATLK 424
Query: 205 GL-SQGLVDREKGL--SAEPGWQAKREEEEEEEEEA-------------EAGEEAVPEEE 248
L +QG+ K P ++ K+ ++ ++ E+ E E+ VPE+E
Sbjct: 425 LLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKE 484
Query: 249 GPTVVLNPHPS-----LGYKEIRKGESRSEALAVDGAGKPGAEEAQDPEGKGEQEHSQQK 303
+ P G + S E V+G K E ++PE E+E +++
Sbjct: 485 ETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEG-NKVHIEVKENPE---EEEEEEEE 540
Query: 304 EEEEEMAVVPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRLEGQEE 363
EEE+E + + + E ++E+E++S E + K K + +KE++++ + ++
Sbjct: 541 EEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDK--KPSKEMSSDSEYDSDDD 598
Score = 35.8 bits (81), Expect = 0.083
Identities = 37/197 (18%), Positives = 85/197 (43%), Gaps = 23/197 (11%)
Query: 260 LGYKEIRKGESRSE--------ALAVDGAGKPGAEEAQDPEGKGEQEHSQQKEEEEEMAV 311
+G K+ K E ++ A ++GAG +E Q +GK ++E +Q +E+++
Sbjct: 1 MGKKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILK 60
Query: 312 VPQGLFRGGKSGELEQEEERLSKEWEDSKRWSKMDQLAKELTAEKRL--EGQEEEEDNRD 369
+ L + + ++E + + + ++ D+ K +K+ + EE +++D
Sbjct: 61 ELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120
Query: 370 SSMKLSFRARAYGFRGPGPQLRRGWRPSSREDSLEAGLPLQVRGYPEE-KKEEEGSANRR 428
S K + + + + G S +D LP + +G ++ K+ +GS
Sbjct: 121 SKSKKTAKPKVEMYSG------------SDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDE 168
Query: 429 PEDQELESLSAIEAELE 445
++++ S I + E
Sbjct: 169 DNSKKIKERSRINSSGE 185
Score = 34.7 bits (78), Expect = 0.18
Identities = 36/137 (26%), Positives = 58/137 (42%), Gaps = 26/137 (18%)
Query: 102 DELSEVLENQSSQAELKEAVEEPSSKDVMEKREDSKEAEKSGEATDGARPQALPEPMQES 161
DE +E +E E+KE EE ++ E+ E+ +E+E +E
Sbjct: 512 DEETEKVEGNKVHIEVKENPEEEEEEE--EEEEEDEESE------------------EEE 551
Query: 162 KAEGNNQAPGEEEEEEEEATNTHPPASLPSQKYPGPQAEGDSEGLSQGLVDREKGLSAEP 221
+ EG ++ G E +EE+E + + K P + DSE S DR K A
Sbjct: 552 EEEGESE--GSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDD--DRTKEERAYD 607
Query: 222 GWQAKREEEEEEEEEAE 238
+AKR E+ E ++
Sbjct: 608 --KAKRRIEKRRLEHSK 622
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.302 0.124 0.336
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,534,776
Number of Sequences: 37866
Number of extensions: 1324340
Number of successful extensions: 23447
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 374
Number of HSP's successfully gapped in prelim test: 1274
Number of HSP's that attempted gapping in prelim test: 8888
Number of HSP's gapped (non-prelim): 7228
length of query: 457
length of database: 18,247,518
effective HSP length: 106
effective length of query: 351
effective length of database: 14,233,722
effective search space: 4996036422
effective search space used: 4996036422
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.