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Search of human proteins with 4502249
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain
2 isoform a [Homo sapiens]
(1006 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ... 2035 0.0
gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 1909 0.0
gi|46094081 development and differentiation enhancing factor 1 [... 1135 0.0
gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain... 778 0.0
gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domai... 743 0.0
gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH doma... 187 4e-47
gi|187608516 centaurin, beta 2 [Homo sapiens] 184 3e-46
gi|7661880 centaurin beta1 [Homo sapiens] 177 6e-44
gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens] 118 3e-26
gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens] 115 3e-25
gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens] 115 3e-25
gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH do... 113 1e-24
gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH do... 112 2e-24
gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activat... 112 2e-24
gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens] 112 2e-24
gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens] 110 9e-24
gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens] 110 9e-24
gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH do... 110 9e-24
gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH do... 108 3e-23
gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 106 1e-22
gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repea... 106 1e-22
gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH do... 96 2e-19
gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 96 2e-19
gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 89 3e-17
gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH dom... 82 3e-15
gi|113204622 stromal membrane-associated GTPase-activating prote... 79 2e-14
gi|21264558 stromal membrane-associated GTPase-activating protei... 79 2e-14
gi|28416436 ADP-ribosylation factor GTPase activating protein 1 ... 78 4e-14
gi|8922652 ADP-ribosylation factor GTPase activating protein 1 i... 78 4e-14
gi|23943872 small ArfGAP2 [Homo sapiens] 76 2e-13
>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform a [Homo sapiens]
Length = 1006
Score = 2035 bits (5272), Expect = 0.0
Identities = 1006/1006 (100%), Positives = 1006/1006 (100%)
Query: 1 MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA 60
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA
Sbjct: 1 MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA 60
Query: 61 INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN 120
INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN
Sbjct: 61 INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN 120
Query: 121 NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG 180
NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG
Sbjct: 121 NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG 180
Query: 181 AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES 240
AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES
Sbjct: 181 AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES 240
Query: 241 LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG 300
LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG
Sbjct: 241 LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG 300
Query: 301 NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP 360
NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP
Sbjct: 301 NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP 360
Query: 361 EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT 420
EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT
Sbjct: 361 EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT 420
Query: 421 KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV 480
KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV
Sbjct: 421 KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV 480
Query: 481 LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH
Sbjct: 481 LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
Query: 541 ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS 600
ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS
Sbjct: 541 ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS 600
Query: 601 LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI 660
LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI
Sbjct: 601 LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI 660
Query: 661 AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP 720
AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP
Sbjct: 661 AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP 720
Query: 721 ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPS 780
ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPS
Sbjct: 721 ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPS 780
Query: 781 TTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTN 840
TTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTN
Sbjct: 781 TTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTN 840
Query: 841 PLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKST 900
PLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKST
Sbjct: 841 PLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKST 900
Query: 901 PLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNP 960
PLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNP
Sbjct: 901 PLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNP 960
Query: 961 DELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD 1006
DELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD
Sbjct: 961 DELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD 1006
>gi|206597522 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
isoform b [Homo sapiens]
Length = 961
Score = 1909 bits (4945), Expect = 0.0
Identities = 957/1006 (95%), Positives = 957/1006 (95%), Gaps = 45/1006 (4%)
Query: 1 MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA 60
MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA
Sbjct: 1 MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA 60
Query: 61 INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN 120
INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN
Sbjct: 61 INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN 120
Query: 121 NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG 180
NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG
Sbjct: 121 NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG 180
Query: 181 AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES 240
AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES
Sbjct: 181 AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES 240
Query: 241 LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG 300
LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG
Sbjct: 241 LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG 300
Query: 301 NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP 360
NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP
Sbjct: 301 NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP 360
Query: 361 EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT 420
EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT
Sbjct: 361 EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT 420
Query: 421 KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV 480
KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV
Sbjct: 421 KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV 480
Query: 481 LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH
Sbjct: 481 LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
Query: 541 ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS 600
ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS
Sbjct: 541 ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS 600
Query: 601 LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI 660
LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI
Sbjct: 601 LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI 660
Query: 661 AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP 720
AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP
Sbjct: 661 AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP 720
Query: 721 ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPS 780
ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPS
Sbjct: 721 ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSGSPPPAQPAAPS 780
Query: 781 TTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHPPLPPLRVTSTN 840
TTSAPPLPPRNVGK DP PP
Sbjct: 781 TTSAPPLPPRNVGK----------------------------DPLTPTPP---------- 802
Query: 841 PLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKST 900
PPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKST
Sbjct: 803 -------PPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAPGADKST 855
Query: 901 PLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNP 960
PLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNP
Sbjct: 856 PLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNP 915
Query: 961 DELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD 1006
DELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD
Sbjct: 916 DELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD 961
>gi|46094081 development and differentiation enhancing factor 1 [Homo
sapiens]
Length = 1129
Score = 1135 bits (2935), Expect = 0.0
Identities = 631/1127 (55%), Positives = 757/1127 (67%), Gaps = 139/1127 (12%)
Query: 1 MPDQISVSEFVAETHEDYKAPTASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVKA 60
MPDQISVSEF+AET EDY +PT SSFTTR CRNTV +EEALD DR L K+KKSVKA
Sbjct: 21 MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKA 80
Query: 61 INSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNMN 120
I +SG HV+NEE Y Q L+KFG N + RD+PDLG+AF+KFS TKEL+ L KNL+Q ++
Sbjct: 81 IYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLS 140
Query: 121 NIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEISG 180
+ + F LDSLLKGDLKGVKGDLKKPFDKAWKDYETK TKIEKEK+EHAK HGMIRTEI+G
Sbjct: 141 HNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITG 200
Query: 181 AEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVES 240
AEIAEEMEKERR FQLQMCEYL+KVNEIK KKGVDLLQNLIKY+HAQCNFFQDGLK +
Sbjct: 201 AEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADK 260
Query: 241 LKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTAYSLHQPQG 300
LK IE L+ DL+ IKQ QDEE++QL LRD++KS+LQ++QKEDSQ RQ YS+HQ QG
Sbjct: 261 LKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKEDSQSRQG-GYSMHQLQG 319
Query: 301 NKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVKTNP 360
NKE+G+E+ G L KKSDGIRKVWQ+RKCSVKNG LTISH T+NR PAKLNLLTCQVK N
Sbjct: 320 NKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNA 379
Query: 361 EEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT 420
E+KK FDLISH+RTYHFQAEDEQ+ W+SVL NSKEEAL AF+G+ + GEN++ ++LT
Sbjct: 380 EDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSL-EDLT 438
Query: 421 KEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV 480
K II +VQR+ GND+CCDCG+ +PTWLSTNLGILTCIECSGIHRE+GVH SR+QSL LD
Sbjct: 439 KAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDK 498
Query: 481 LGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
LGTSELLLAKN+GN FN+IME LP+ S KP P SDM RK+YITAKY++ R++RK
Sbjct: 499 LGTSELLLAKNVGNNSFNDIMEANLPSP-SPKPTPSSDMTVRKEYITAKYVDHRFSRKTC 557
Query: 541 ADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTS 600
+ ++AKL+ L EA+K+RD+ L+Q YA+GV+L E + L G E ETALHLAVR+ D+TS
Sbjct: 558 STSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPL-LEPGQELGETALHLAVRTADQTS 616
Query: 601 LHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDI 660
LH+VDFLVQN GNLDKQT G+T LHYC + ECLKLLLR K +++I N++GET LDI
Sbjct: 617 LHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDI 676
Query: 661 AKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKLQPSPNRREDRP 720
AKRLK CE+LL+QA SG+FN HVHVEYEW L E++DESDDD+D+K P R RP
Sbjct: 677 AKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRP 736
Query: 721 ISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSG---SPPPAQPA 777
SF S Q LA + ++KQR +YGA + S P
Sbjct: 737 QSFCHSSSISPQDK---LALPGFSTPRDKQRL---------SYGAFTNQIFVSTSTDSPT 784
Query: 778 APSTTSAPPLPPRNVGK------------VQTASSANTLWKT------------------ 807
+P TT APPLPPRN GK QT+S ++TL K
Sbjct: 785 SP-TTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPS 843
Query: 808 -------NSVSV----DGG--------------SRQRSSSDP-----PAVHPPLPP---L 834
N +V DGG S+Q S+S P V P LP L
Sbjct: 844 PLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVAL 903
Query: 835 RVTSTNPLTP-TPPPPVAKTPSVMEALSQ-------PSKPA-----------PPGISQIR 875
R T L T PP + + S + L Q P KP PP ++
Sbjct: 904 RKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELP 963
Query: 876 PPP----LPPQPP-SRLPQK--------KP--------------APGADKSTPLTNKGQP 908
P P LPP+P S LP K KP +P A + + +T K P
Sbjct: 964 PKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHP 1023
Query: 909 ---------RGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADN 959
R + A+E L+ + + P P+PRK K K +RVK +Y+C ADN
Sbjct: 1024 LDLSPNVQSRDAIQKQASEDSNDLTPTLP-ETPVPLPRKINTGKNKVRRVKTIYDCQADN 1082
Query: 960 PDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGAFPVSFVHFIAD 1006
DELTF EG+VIIV GEEDQEWWIGHI+G P RKG FPVSFVH ++D
Sbjct: 1083 DDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD 1129
>gi|19923540 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform a [Homo sapiens]
Length = 903
Score = 778 bits (2009), Expect = 0.0
Identities = 435/954 (45%), Positives = 589/954 (61%), Gaps = 76/954 (7%)
Query: 1 MPDQISVSEFVAETHEDYKAPT-ASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVK 59
MP+Q SV+EF+A T ED +P A++F + + R A EE L+ D+ +L ++KK+V+
Sbjct: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
Query: 60 AINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNM 119
AI+SSGL HVENEEQY +A+E G + + ++ +L + FL +VFT+E+ ALFKNLIQN+
Sbjct: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
Query: 120 NNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEIS 179
NNI+SFPLDSL+KG L+ + D KK +KAWKDYE K+ K+EKE+ + A++ G I
Sbjct: 121 NNIVSFPLDSLMKGQLRDGRQDSKKQLEKAWKDYEAKMAKLEKER-DRARVTGGIP---- 175
Query: 180 GAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVE 239
E+A++M++ERR FQL MCEYLLK E ++K+G D LQ+LIK+FHAQ NFFQDG KA +
Sbjct: 176 -GEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQ 234
Query: 240 SLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTA--YSLHQ 297
SL P IE L+ +H + QAQ++E ++L QLRD L+ LQ+E +E+ R+++ YS+HQ
Sbjct: 235 SLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQ 294
Query: 298 PQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVK 357
QGNK+ GTE+ G LYKKSDGIR+VWQKRKC VK G LTISH T NRPP KL LLTCQV+
Sbjct: 295 HQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVR 354
Query: 358 TNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGD--------DN 409
NPEEKKCFDL++H+RTYHFQAEDE EC+ W+SVLQNSK+EAL++AF G+ +
Sbjct: 355 PNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 414
Query: 410 TGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVH 469
G + +LTK +I+EV+ GN CCDCGA DPTWLSTNLG+LTCI+CSG+HRELGV
Sbjct: 415 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 474
Query: 470 YSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAK 529
+SRMQSLTLD+LG SELLLA N+GN FNE+ME LP+ KP+ SDM R+DYI AK
Sbjct: 475 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 534
Query: 530 YIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETAL 589
Y+E R+AR+ + L A+ RD+ +L+A+A+G D + +P + P+E L
Sbjct: 535 YVEHRFARR----CTPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVL 590
Query: 590 HLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEI 649
HLAV+ ++ SL +VDF++QN G+LD + G+TALHY L + +CLKLLL+G+A +
Sbjct: 591 HLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGT 650
Query: 650 ANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKL 709
NE+GET LDIA++ H+ CEELL QA +G F +HV+Y W + E +S++D +EK
Sbjct: 651 VNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEK- 709
Query: 710 QPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSG 769
R L + A + N+TY +
Sbjct: 710 ------------------------------RCLLKLPAQAHWASGRLDISNKTYETV--A 737
Query: 770 SPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHP 829
S A P S PPLP +N + A S D SS+ P
Sbjct: 738 SLGAATPQGESEDCPPPLPVKNSSRTLVQGCA------RHASGDRSEVSSLSSEAPETPE 791
Query: 830 PL--PPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPP---LPPQPP 884
L P + +PL P P P+ E L +P + P ++ P LP +
Sbjct: 792 SLGSPASSSSLMSPLEPGDPSQA--PPNSEEGLREPPGTSRPSLTSGTTPSEMYLPVRFS 849
Query: 885 S------RLPQKKPAPGADKSTPLTNKGQPRGPV--DLSATEALGPLSNAMVLQ 930
S R + P G PL + P G D S T +L P S+ +LQ
Sbjct: 850 SESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSL-PASSVQLLQ 902
>gi|221307473 ArfGAP with SH3 domain, ankyrin repeat and PH domain 3
isoform b [Homo sapiens]
Length = 894
Score = 743 bits (1919), Expect = 0.0
Identities = 425/954 (44%), Positives = 578/954 (60%), Gaps = 85/954 (8%)
Query: 1 MPDQISVSEFVAETHEDYKAPT-ASSFTTRTAQCRNTVAAIEEALDVDRMVLYKMKKSVK 59
MP+Q SV+EF+A T ED +P A++F + + R A EE L+ D+ +L ++KK+V+
Sbjct: 1 MPEQFSVAEFLAVTAEDLSSPAGAAAFAAKMPRYRGAALAREEILEGDQAILQRIKKAVR 60
Query: 60 AINSSGLAHVENEEQYTQALEKFGGNCVCRDDPDLGSAFLKFSVFTKELTALFKNLIQNM 119
AI+SSGL HVENEEQY +A+E G + + ++ +L + FL +VFT+E+ ALFKNLIQN+
Sbjct: 61 AIHSSGLGHVENEEQYREAVESLGNSHLSQNSHELSTGFLNLAVFTREVAALFKNLIQNL 120
Query: 120 NNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDYETKITKIEKEKKEHAKLHGMIRTEIS 179
NNI+SFPLDSL+KG L+ + +A K+EKE+ + A++ G I
Sbjct: 121 NNIVSFPLDSLMKGQLRDGRQASLSLGSRA---------KLEKER-DRARVTGGIP---- 166
Query: 180 GAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKGVDLLQNLIKYFHAQCNFFQDGLKAVE 239
E+A++M++ERR FQL MCEYLLK E ++K+G D LQ+LIK+FHAQ NFFQDG KA +
Sbjct: 167 -GEVAQDMQRERRIFQLHMCEYLLKAGESQMKQGPDFLQSLIKFFHAQHNFFQDGWKAAQ 225
Query: 240 SLKPSIETLSTDLHTIKQAQDEERRQLIQLRDILKSALQVEQKEDSQIRQSTA--YSLHQ 297
SL P IE L+ +H + QAQ++E ++L QLRD L+ LQ+E +E+ R+++ YS+HQ
Sbjct: 226 SLFPFIEKLAASVHALHQAQEDELQKLTQLRDSLRGTLQLESREEHLSRKNSGCGYSIHQ 285
Query: 298 PQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQVK 357
QGNK+ GTE+ G LYKKSDGIR+VWQKRKC VK G LTISH T NRPP KL LLTCQV+
Sbjct: 286 HQGNKQFGTEKVGFLYKKSDGIRRVWQKRKCGVKYGCLTISHSTINRPPVKLTLLTCQVR 345
Query: 358 TNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGD--------DN 409
NPEEKKCFDL++H+RTYHFQAEDE EC+ W+SVLQNSK+EAL++AF G+ +
Sbjct: 346 PNPEEKKCFDLVTHNRTYHFQAEDEHECEAWVSVLQNSKDEALSSAFLGEPSAGPGSWGS 405
Query: 410 TGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVH 469
G + +LTK +I+EV+ GN CCDCGA DPTWLSTNLG+LTCI+CSG+HRELGV
Sbjct: 406 AGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNLGVLTCIQCSGVHRELGVR 465
Query: 470 YSRMQSLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAK 529
+SRMQSLTLD+LG SELLLA N+GN FNE+ME LP+ KP+ SDM R+DYI AK
Sbjct: 466 FSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQLPSHGGPKPSAESDMGTRRDYIMAK 525
Query: 530 YIERRYARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETAL 589
Y+E R+AR+ + L A+ RD+ +L+A+A+G D + +P + P+E L
Sbjct: 526 YVEHRFARR----CTPEPQRLWTAICNRDLLSVLEAFANGQDFGQPLPGPDAQAPEELVL 581
Query: 590 HLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEI 649
HLAV+ ++ SL +VDF++QN G+LD + G+TALHY L + +CLKLLL+G+A +
Sbjct: 582 HLAVKVANQASLPLVDFIIQNGGHLDAKAADGNTALHYAALYNQPDCLKLLLKGRALVGT 641
Query: 650 ANESGETPLDIAKRLKHEHCEELLTQALSGRFNSHVHVEYEWRLLHEDLDESDDDMDEKL 709
NE+GET LDIA++ H+ CEELL QA +G F +HV+Y W + E +S++D +EK
Sbjct: 642 VNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWVISTEPGSDSEEDEEEK- 700
Query: 710 QPSPNRREDRPISFYQLGSNQLQSNAVSLARDAANLAKEKQRAFMPSILQNETYGALLSG 769
R L + A + N+TY +
Sbjct: 701 ------------------------------RCLLKLPAQAHWASGRLDISNKTYETV--A 728
Query: 770 SPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHP 829
S A P S PPLP +N + A S D SS+ P
Sbjct: 729 SLGAATPQGESEDCPPPLPVKNSSRTLVQGCA------RHASGDRSEVSSLSSEAPETPE 782
Query: 830 PL--PPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPP---LPPQPP 884
L P + +PL P P P+ E L +P + P ++ P LP +
Sbjct: 783 SLGSPASSSSLMSPLEPGDPSQA--PPNSEEGLREPPGTSRPSLTSGTTPSEMYLPVRFS 840
Query: 885 S------RLPQKKPAPGADKSTPLTNKGQPRGPV--DLSATEALGPLSNAMVLQ 930
S R + P G PL + P G D S T +L P S+ +LQ
Sbjct: 841 SESTRSYRRGARSPEDGPSARQPLPRRNVPVGITEGDGSRTGSL-PASSVQLLQ 893
>gi|218563749 ArfGAP with coiled-coil, ankyrin repeat and PH domains
3 [Homo sapiens]
Length = 834
Score = 187 bits (475), Expect = 4e-47
Identities = 138/533 (25%), Positives = 233/533 (43%), Gaps = 56/533 (10%)
Query: 34 RNTVAAIEEALDVDRMVLYKMKKSVKAINSSGLAHVENEEQYTQALEKFGGNCVCRDDPD 93
R T+ +E + L K+ K + +G A+V + + C + D
Sbjct: 16 RATIDEVETDVVEIEAKLDKLVKLCSGMVEAGKAYVSTSRLFVSGVRDLSQQC--QGDTV 73
Query: 94 LGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDY 153
+ +F+ +E+ L + L S +K D++ K + KK FDK +D
Sbjct: 74 ISECLQRFADSLQEVVNYHMILFDQAQRSVRQQLQSFVKEDVRKFK-ETKKQFDKVREDL 132
Query: 154 ETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKIKKG 213
E + + A H E E + R+ F+ +Y+L++N ++ KK
Sbjct: 133 ELSLVR-----NAQAPRHRPHEVE----EATGALTLTRKCFRHLALDYVLQINVLQAKKK 183
Query: 214 VDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLH------TIKQAQDEERRQLI 267
++L +++ + HAQ +FFQ G + L P ++ L+ +L +++ + E + I
Sbjct: 184 FEILDSMLSFMHAQSSFFQQGYSLLHQLDPYMKKLAAELDQLVIDSAVEKREMERKHAAI 243
Query: 268 QLRDILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRK 327
Q R +L+ E K + + + G G L+K++ K W +R
Sbjct: 244 QQRTLLQDFSYDESKVEFDV-------------DAPSGVVMEGYLFKRASNAFKTWNRRW 290
Query: 328 CSVKNGFLTISHGTANRPPAKLN-LLTCQVKT--NPEEKKCFDLISHDRTYHFQAEDEQE 384
S++N L + ++ L C VK + E + CF+++S ++ QA+ E+
Sbjct: 291 FSIQNSQLVYQKKLKDALTVVVDDLRLCSVKPCEDIERRFCFEVLSPTKSCMLQADSEKL 350
Query: 385 CQIWMSVLQNSKEEALN-------------------NAFKGDDNTGENNIVQELTKEIIS 425
Q W+ +Q S A ++ +T E + E ++
Sbjct: 351 RQAWVQAVQASIASAYRESPDSCYSERLDRTASPSTSSIDSATDTRERGVKGE---SVLQ 407
Query: 426 EVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSE 485
VQ + GN C DCG PDP W S NLG+L CIECSGIHR LGVH S+++SLTLD
Sbjct: 408 RVQSVAGNSQCGDCGQPDPRWASINLGVLLCIECSGIHRSLGVHCSKVRSLTLDSWEPEL 467
Query: 486 LLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARK 538
L L +GN+ N+I E S KP S ++ +I KY+E+++ RK
Sbjct: 468 LKLMCELGNSAVNQIYEAQCEGAGSRKPTASSSRQDKEAWIKDKYVEKKFLRK 520
Score = 38.9 bits (89), Expect = 0.025
Identities = 32/124 (25%), Positives = 57/124 (45%), Gaps = 7/124 (5%)
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
A + RD+ L A A G ++ A+ + +T L V++V SL + +FL+QN
Sbjct: 675 AARARDLPALAAALAHGAEVN----WADAEDEGKTPL---VQAVLGGSLIVCEFLLQNGA 727
Query: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEEL 672
+++++ +G LH+ L + L L+ A ++ PL IA + + L
Sbjct: 728 DVNQRDSRGRAPLHHATLLGRTGQVCLFLKRGADQHALDQEQRDPLAIAVQAANADIVTL 787
Query: 673 LTQA 676
L A
Sbjct: 788 LRLA 791
>gi|187608516 centaurin, beta 2 [Homo sapiens]
Length = 778
Score = 184 bits (468), Expect = 3e-46
Identities = 147/527 (27%), Positives = 243/527 (46%), Gaps = 56/527 (10%)
Query: 38 AAIEEAL-DVDRMVLYKMKKSVK---AINSSGLAHVENEEQYTQALEKFGGNCVCRDDPD 93
AA+EE DV + L K+ K VK A+ +G A +Q+ + +D
Sbjct: 19 AALEEVEGDVAELEL-KLDKLVKLCIAMIDTGKAFCVANKQFMNGIRDLAQ--YSSNDAV 75
Query: 94 LGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAWKDY 153
+ ++ KFS +E+ L I L + +K DL+ K D KK F+K ++
Sbjct: 76 VETSLTKFSDSLQEMINFHTILFDQTQRSIKAQLQNFVKEDLRKFK-DAKKQFEKVSEEK 134
Query: 154 ETKITK---IEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKI 210
E + K +++ K+ + E + R+ F+ +Y+L++N ++
Sbjct: 135 ENALVKNAQVQRNKQHEVE------------EATNILTATRKCFRHIALDYVLQINVLQS 182
Query: 211 KKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLR 270
K+ ++L++++ + +A FF G L P ++ L L + +E+R++ Q
Sbjct: 183 KRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMKDLGAQLDRLVVDAAKEKREMEQKH 242
Query: 271 DILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSV 330
++QK+ S Y++ + +G G L+K++ K W +R S+
Sbjct: 243 ST------IQQKDFSSDDSKLEYNV-----DAANGIVMEGYLFKRASNAFKTWNRRWFSI 291
Query: 331 KNGFLTISHGTANRPPAKL-NLLTCQVK--TNPEEKKCFDLISHDRTYHFQAEDEQECQI 387
+N L + P + +L C VK + E + CF+++S ++ QA+ E+ Q
Sbjct: 292 QNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVSPTKSCMLQADSEKLRQA 351
Query: 388 WMSVLQNSKEEALNNAFKGDDN----------TGE----NNIVQELTK--EIISEVQRMT 431
W+ +Q S A KGD++ TG N ++L K + VQ +
Sbjct: 352 WIKAVQTSIATAYRE--KGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIP 409
Query: 432 GNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKN 491
GN CCDCG DP W S NLGI CIECSGIHR LGVH+S+++SLTLD L L
Sbjct: 410 GNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCE 469
Query: 492 IGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARK 538
+GN N + E + KP PG ++ YI AKY+ER++ K
Sbjct: 470 LGNDVINRVYEANVEKMGIKKPQPG-QRQEKEAYIRAKYVERKFVDK 515
Score = 40.0 bits (92), Expect = 0.011
Identities = 33/123 (26%), Positives = 60/123 (48%), Gaps = 10/123 (8%)
Query: 539 KHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDR 598
KH + +L+ A +++ + +A A G D+ AN E T L +++V
Sbjct: 602 KHLNPGLQLY---RASYEKNLPKMAEALAHGADVN----WANSEENKATPL---IQAVLG 651
Query: 599 TSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLRGKASIEIANESGETPL 658
SL +FL+QN N++++ +G LH+ + + + L L+ A+ +E G+ PL
Sbjct: 652 GSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGHTGQVCLFLKRGANQHATDEEGKDPL 711
Query: 659 DIA 661
IA
Sbjct: 712 SIA 714
>gi|7661880 centaurin beta1 [Homo sapiens]
Length = 740
Score = 177 bits (448), Expect = 6e-44
Identities = 145/650 (22%), Positives = 264/650 (40%), Gaps = 91/650 (14%)
Query: 91 DPDLGSAFLKFSVFTKELTALFKNLIQNMNNIISFPLDSLLKGDLKGVKGDLKKPFDKAW 150
+P + KF+V L+ + + + +L+K L+G + + ++ F +
Sbjct: 73 EPMMAECLEKFTVSLNHKLDSHAELLDATQHTLQQQIQTLVKEGLRGFR-EARRDFWRGA 131
Query: 151 KDYETKITKIEKEKKEHAKLHGMIRTEISGAEIAEEMEKERRFFQLQMCEYLLKVNEIKI 210
+ E +T + + A+ E + R ++ + +Y L++N I+
Sbjct: 132 ESLEAALTHNAEVPRRRAQ---------EAEEAGAALRTARAGYRGRALDYALQINVIED 182
Query: 211 KKGVDLLQNLIKYFHAQCNFFQDGLKAVESLKPSIETLSTDLHTIKQAQDEERRQLIQLR 270
K+ D+++ +++ AQ FQ G + + L + L LH + E+R + Q
Sbjct: 183 KRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRKELGAQLHQLVLNSAREKRDMEQRH 242
Query: 271 DILKSALQVEQKEDSQIRQSTAYSLHQPQGNKEHGTERNGSLYKKSDGIRKVWQKRKCSV 330
+LK ++ + +R+ G G L+K++ K W +R ++
Sbjct: 243 VLLKQKELGGEEPEPSLREGPG------------GLVMEGHLFKRASNAFKTWSRRWFTI 290
Query: 331 KNGFLTISHGTANRPPAKL---NLLTCQVKTNPEEKK--CFDLISHDRTYHFQAEDEQEC 385
++ L + + P + +L C VK P+ ++ CF+++S ++ QA+ E+
Sbjct: 291 QSNQLV--YQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVSTSKSCLLQADSERLL 348
Query: 386 QIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELT---------------------KEII 424
Q+W+S +Q+S A + A D G L ++
Sbjct: 349 QLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATLGSGGMARGREPGGVGHVV 408
Query: 425 SEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTS 484
++VQ + GN CCDC P P W S NLG+ CI+CSGIHR LGVH+S+++SLTLD
Sbjct: 409 AQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLTLDSWEPE 468
Query: 485 ELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARK------ 538
+ L +GN N+I E + A KP P ++ +I AKY+E+++ K
Sbjct: 469 LVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEIRG 528
Query: 539 --------------------------------KHADNAAKLHSLCEAVKTRDIFGLLQAY 566
+++ LH + L
Sbjct: 529 RRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDLGSLHPGALLFRASGHPPSLPTM 588
Query: 567 ADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSGNLDKQTGKGSTALH 626
AD + + NG + + T L +++ SL +FL+QN N+++ G LH
Sbjct: 589 ADALAHGADVNWVNGGQDNATPL---IQATAANSLLACEFLLQNGANVNQADSAGRGPLH 645
Query: 627 YCCLTDNAECLKLLLRGKASIEIANESGETPLDIAKRLKHEHCEELLTQA 676
+ + + L L+ A + + G PL IA + LL A
Sbjct: 646 HATILGHTGLACLFLKRGADLGARDSEGRDPLTIAMETANADIVTLLRLA 695
>gi|110227613 centaurin, gamma 3 isoform a [Homo sapiens]
Length = 911
Score = 118 bits (295), Expect = 3e-26
Identities = 82/270 (30%), Positives = 124/270 (45%), Gaps = 10/270 (3%)
Query: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
+T+HF+A +E ++W+ +Q +L D T N L + V+ + G
Sbjct: 617 QTWHFEASTAEERELWVQSVQAQILASLQGCRSAKDKTRLGNQNAALA---VQAVRTVRG 673
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C DC AP+P W S NLG L CIECSGIHR LG H SR++SL LD L + +
Sbjct: 674 NSFCIDCDAPNPDWASLNLGALMCIECSGIHRHLGAHLSRVRSLDLDDWPPELLAVMTAM 733
Query: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
GNA N + E L KP P + ++ +I AKY ++ + + + L
Sbjct: 734 GNALANSVWEGALGGYS--KPGPDACREEKERWIRAKYEQKLFLAPLPSSDVPLGQQLLR 791
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
AV D+ L+ A G E++ G TALHL S ++ L+
Sbjct: 792 AVVEDDLRLLVMLLAHG--SKEEVNETYGDGDGRTALHL---SSAMANVVFTQLLIWYGV 846
Query: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
++ + +G T L Y + EC +L++
Sbjct: 847 DVRSRDARGLTPLAYARRAGSQECADILIQ 876
>gi|80978934 centaurin, gamma 2 isoform 2 [Homo sapiens]
Length = 804
Score = 115 bits (287), Expect = 3e-25
Identities = 77/288 (26%), Positives = 135/288 (46%), Gaps = 13/288 (4%)
Query: 358 TNPEEKKCFDLISHD---RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENN 414
T E+++ F+ I +T+HF+A +E W+ +++ +L + + + ++
Sbjct: 493 TAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSC---ESSKNKSR 549
Query: 415 IVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQ 474
+ + + ++ M GN C DC +P W S NLG L CIECSGIHR LG H SR++
Sbjct: 550 LTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVR 609
Query: 475 SLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERR 534
SL LD + + +IGN N + E ++ KP+ S ++ +I AKY ++
Sbjct: 610 SLDLDDWPVELIKVMSSIGNELANSVWE--ESSQGRTKPSVDSTREEKERWIRAKYEQKL 667
Query: 535 YARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVR 594
+ + L A D+ + A G +++ G TALHLA R
Sbjct: 668 FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHG--SRDEVNETCGEGDGRTALHLACR 725
Query: 595 SVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
+ ++ + L+ ++ + G+TAL Y + EC+ +LL+
Sbjct: 726 ---KGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 770
>gi|80978930 centaurin, gamma 2 isoform 1 [Homo sapiens]
Length = 857
Score = 115 bits (287), Expect = 3e-25
Identities = 77/288 (26%), Positives = 135/288 (46%), Gaps = 13/288 (4%)
Query: 358 TNPEEKKCFDLISHD---RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENN 414
T E+++ F+ I +T+HF+A +E W+ +++ +L + + + ++
Sbjct: 546 TAEEQEENFEFIIVSLTGQTWHFEATTYEERDAWVQAIESQILASLQSC---ESSKNKSR 602
Query: 415 IVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQ 474
+ + + ++ M GN C DC +P W S NLG L CIECSGIHR LG H SR++
Sbjct: 603 LTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVR 662
Query: 475 SLTLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERR 534
SL LD + + +IGN N + E ++ KP+ S ++ +I AKY ++
Sbjct: 663 SLDLDDWPVELIKVMSSIGNELANSVWE--ESSQGRTKPSVDSTREEKERWIRAKYEQKL 720
Query: 535 YARKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVR 594
+ + L A D+ + A G +++ G TALHLA R
Sbjct: 721 FLAPLPCTELSLGQHLLRATADEDLRTAILLLAHG--SRDEVNETCGEGDGRTALHLACR 778
Query: 595 SVDRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
+ ++ + L+ ++ + G+TAL Y + EC+ +LL+
Sbjct: 779 ---KGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLLQ 823
>gi|156104893 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 4 [Homo sapiens]
Length = 663
Score = 113 bits (282), Expect = 1e-24
Identities = 76/270 (28%), Positives = 126/270 (46%), Gaps = 10/270 (3%)
Query: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
+T+HF+A +E W+ +Q+ +L + + + ++ + + + +Q M G
Sbjct: 396 QTWHFEATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLTSQSKAMALQSIQNMRG 452
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C DC +P W S NLG+L CIECSGIHR LG SR++SL LD + +I
Sbjct: 453 NAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSI 512
Query: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
GN N I E ++ KP+ S ++ +I +KY E+ + + L
Sbjct: 513 GNDLANSIWEG--SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLR 570
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
A D+ + A G E++ G TALHLA R + ++ + L+
Sbjct: 571 ATADEDLQTAILLLAHG--SREEVNETCGEGDGCTALHLACR---KGNVVLAQLLIWYGV 625
Query: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
++ + G+TAL Y + EC+ +LL+
Sbjct: 626 DVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|117956373 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 7 [Homo sapiens]
Length = 663
Score = 112 bits (280), Expect = 2e-24
Identities = 76/270 (28%), Positives = 125/270 (46%), Gaps = 10/270 (3%)
Query: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
+T+HF+A +E W+ +Q+ +L + + + ++ + + + +Q M G
Sbjct: 396 QTWHFEATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLTSQSEAMALQSIQNMRG 452
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C DC +P W S NLG+L CIECSGIHR LG SR++SL LD + +I
Sbjct: 453 NAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSI 512
Query: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
GN N I E ++ KP S ++ +I +KY E+ + + L
Sbjct: 513 GNDLANSIWEG--SSQGRTKPTEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLR 570
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
A D+ + A G E++ G TALHLA R + ++ + L+
Sbjct: 571 ATADEDLQTAILLLAHG--SREEVNETCGEGDGCTALHLACR---KGNVVLAQLLIWYGV 625
Query: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
++ + G+TAL Y + EC+ +LL+
Sbjct: 626 DVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|148806877 ankyrin repeat and GTPase domain Arf GTPase activating
protein 11 [Homo sapiens]
Length = 550
Score = 112 bits (279), Expect = 2e-24
Identities = 80/286 (27%), Positives = 133/286 (46%), Gaps = 11/286 (3%)
Query: 358 TNPEEKKCFDLIS-HDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIV 416
T EE++ F ++S +T HF+A +E W+ +Q+ +L + + + ++ +
Sbjct: 267 TAEEEEEKFMIVSVTGQTCHFKATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLT 323
Query: 417 QELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSL 476
+ + +Q M GN C DC +P W S NLG+L CIECSGIHR LG SR++SL
Sbjct: 324 SQSEAMALQSIQNMRGNSHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSL 383
Query: 477 TLDVLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYA 536
LD + +IGN N I E ++ KP+ S ++ +I +KY + +
Sbjct: 384 ELDDWPVELRKVMSSIGNDLANSIWEG--SSQGQTKPSIESTREEKERWIRSKYEHKLFL 441
Query: 537 RKKHADNAAKLHSLCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSV 596
+ L A D+ + A G E++ G TALHLA R
Sbjct: 442 APLPCTELSLGQHLLRATADEDLRTAILLLAHG--SREEVNETCGEGDGCTALHLACR-- 497
Query: 597 DRTSLHIVDFLVQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
+ ++ + L+ ++ + G+TAL Y + EC+ +LL+
Sbjct: 498 -KGNVVLAQLLIWYGVDVMARDAHGNTALTYARQASSQECINVLLQ 542
>gi|166851846 centaurin, gamma-like family, member 3 [Homo sapiens]
Length = 686
Score = 112 bits (279), Expect = 2e-24
Identities = 76/270 (28%), Positives = 126/270 (46%), Gaps = 10/270 (3%)
Query: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
+T+HF+A +E W+ +Q+ +L + + + ++ + + + +Q M G
Sbjct: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLTSQSEAMALQSIQNMRG 475
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C DC +P W S NLG+L CIECSGIHR LG H SR++SL LD + +I
Sbjct: 476 NAHCVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSI 535
Query: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
N N I E ++ KP+ S ++ +I +KY E+ + + L
Sbjct: 536 VNDLANSIWEG--SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLR 593
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
A D+ + A G E++ G TALHLA R + ++ + L+
Sbjct: 594 ATADEDLQTAILLLAHG--SCEEVNETCGEGDGCTALHLACR---KGNVVLAQLLIWYGV 648
Query: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
++ + G+TAL Y + EC+ +LL+
Sbjct: 649 DVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|170650694 centaurin, gamma 1 isoform PIKE-L [Homo sapiens]
Length = 1192
Score = 110 bits (274), Expect = 9e-24
Identities = 80/275 (29%), Positives = 122/275 (44%), Gaps = 14/275 (5%)
Query: 370 SHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQR 429
S +T+HF+A +E W+ +++ +L ++ + + I ++
Sbjct: 883 STGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVA---IQAIRN 939
Query: 430 MTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLA 489
GN +C DCGAP+PTW S NLG L CIECSGIHR LG H SR++SL LD L+
Sbjct: 940 AKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVL 999
Query: 490 KNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHS 549
IGN N + E KP+ S R+ +I AKY + +
Sbjct: 1000 TAIGNDTANRVWES--DTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQ 1057
Query: 550 LCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDE--TALHLAVRSVDRTSLHIVDFL 607
L AV+ +D+ +L A PL E + + LHLA + + I L
Sbjct: 1058 LWAAVQAQDVATVLLLLAH----ARHGPLDTSVEDPQLRSPLHLA---AELAHVVITQLL 1110
Query: 608 VQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
+ ++ + +G TAL Y + C +LL+
Sbjct: 1111 LWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 1145
Score = 36.6 bits (83), Expect = 0.12
Identities = 45/178 (25%), Positives = 60/178 (33%), Gaps = 33/178 (18%)
Query: 766 LLSGSPPPAQPAAPSTTSA--------PPLPPRNVGKVQTASSANTLWKTNSVSVDGGSR 817
L S PPP P+A + +A P PR + + +++ + S
Sbjct: 24 LESVPPPPPSPSAAAAGAAGARGSETGDPGSPRGAEEPGKKRHERLFHRQDALWISTSSA 83
Query: 818 QRSSSDPPAVHP-PLPPLRVTSTNP------------------LTPTPPPPVAKTPSVME 858
++PPA+ P P P R S P L+P P P A T S
Sbjct: 84 GTGGAEPPALSPAPASPARPVSPAPGRRLSLWAVPPGPPLSGGLSPDPKPGGAPTSSRRP 143
Query: 859 ALSQPS--KPAPPGISQIRPP----PLPPQPPSRLPQKKPAPGADKSTPLTNKGQPRG 910
LS PS P P G + P P P RL P P +T G G
Sbjct: 144 LLSSPSWGGPEPEGRAGGGIPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAG 201
Score = 30.4 bits (67), Expect = 8.7
Identities = 28/71 (39%), Positives = 32/71 (45%), Gaps = 19/71 (26%)
Query: 814 GGSRQRSSSD----PPAVHPPLPPLRVTSTNPLTPTPPPPVAKTPSVMEALSQPSKPAPP 869
G S+ +SD PPA PP PL L PTP P A T A +QP PAPP
Sbjct: 271 GKSKTLDNSDLHPGPPAGSPP--PLT------LPPTPSPATAVTA----ASAQPPGPAPP 318
Query: 870 GISQIRPPPLP 880
+ PP P
Sbjct: 319 ITLE---PPAP 326
>gi|7661962 centaurin, gamma 1 isoform PIKE-S [Homo sapiens]
Length = 836
Score = 110 bits (274), Expect = 9e-24
Identities = 80/275 (29%), Positives = 122/275 (44%), Gaps = 14/275 (5%)
Query: 370 SHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQR 429
S +T+HF+A +E W+ +++ +L ++ + + I ++
Sbjct: 527 STGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVA---IQAIRN 583
Query: 430 MTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLA 489
GN +C DCGAP+PTW S NLG L CIECSGIHR LG H SR++SL LD L+
Sbjct: 584 AKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVL 643
Query: 490 KNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHS 549
IGN N + E KP+ S R+ +I AKY + +
Sbjct: 644 TAIGNDTANRVWES--DTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQ 701
Query: 550 LCEAVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDE--TALHLAVRSVDRTSLHIVDFL 607
L AV+ +D+ +L A PL E + + LHLA + + I L
Sbjct: 702 LWAAVQAQDVATVLLLLAH----ARHGPLDTSVEDPQLRSPLHLA---AELAHVVITQLL 754
Query: 608 VQNSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
+ ++ + +G TAL Y + C +LL+
Sbjct: 755 LWYGADVAARDAQGRTALFYARQAGSQLCADILLQ 789
>gi|117956371 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 8 [Homo sapiens]
Length = 663
Score = 110 bits (274), Expect = 9e-24
Identities = 75/270 (27%), Positives = 125/270 (46%), Gaps = 10/270 (3%)
Query: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
+T+HF+A +E W+ +Q+ +L + + + ++ + + + +Q M G
Sbjct: 396 QTWHFEATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLTSQSEAMALQSIQNMRG 452
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C DC +P W S NLG+L CIECSGIH LG SR++SL LD + +I
Sbjct: 453 NAHCVDCETQNPKWASLNLGVLMCIECSGIHHSLGTRLSRVRSLELDDWPVELRKVMSSI 512
Query: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
GN N I E ++ KP+ S ++ +I +KY E+ + + L
Sbjct: 513 GNDLANSIWEG--SSQGQTKPSEKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQQLLW 570
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
A D+ + A G E++ G TALHLA R + ++ + L+
Sbjct: 571 ATADEDLQTAILLLAHG--SREEVNETCGEGDGCTALHLACR---KGNVVLAQLLIWYGV 625
Query: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
++ + G+TAL Y + EC+ +LL+
Sbjct: 626 DVMARDAHGNTALTYARQASSQECINVLLQ 655
>gi|221136914 ArfGAP with GTPase domain, ankyrin repeat and PH
domain 5 [Homo sapiens]
Length = 686
Score = 108 bits (269), Expect = 3e-23
Identities = 75/270 (27%), Positives = 125/270 (46%), Gaps = 10/270 (3%)
Query: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
+T+HF+A +E W+ +Q+ +L + + + ++ + + + +Q M G
Sbjct: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSC---ESSKSKSQLTSQSEAMALQSIQNMRG 475
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C D +P W S NLG+L CIECSGIHR LG SR++SL LD + +I
Sbjct: 476 NAHCVDYETQNPKWASLNLGVLMCIECSGIHRSLGTRLSRVRSLELDDWPVELRKVMSSI 535
Query: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
GN N I E ++ KP+ S ++ +I +KY E+ + + L
Sbjct: 536 GNDLANSIWEG--SSQGQTKPSVKSTREEKERWIRSKYEEKLFLAPLPCTELSLGQHLLR 593
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRSVDRTSLHIVDFLVQNSG 612
A D+ + A G E++ G TALHLA R + ++ + L+
Sbjct: 594 ATADEDLQTAILLLAHG--SREEVNETCGEGDGCTALHLACR---KGNVVLAQLLIWYGV 648
Query: 613 NLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
++ + G+TAL Y + EC+ +LL+
Sbjct: 649 DVMARDAHGNTALTYARQASSQECINVLLQ 678
>gi|239744074 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 9 [Homo sapiens]
Length = 684
Score = 106 bits (264), Expect = 1e-22
Identities = 78/273 (28%), Positives = 123/273 (45%), Gaps = 18/273 (6%)
Query: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
+T+HF+A +E W+ +Q+ +L + + ++ + + + +Q M G
Sbjct: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSC---KSSKSKSQLTSQSEAMALQSIQNMRG 475
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C DC +P W S NLG+L CIECSGIHR G SR++SL LD + +I
Sbjct: 476 NAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSI 535
Query: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
GN N I E ++ KP+ S ++ +I +KY E+ + + L
Sbjct: 536 GNELANSIWEG--SSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLR 593
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRS---VDRTSLHIVDFLVQ 609
A D+ + A G E++ G TALHLA R V L VD + +
Sbjct: 594 ATTDEDLQTAILLLAHG--SREEVNETCGEGDGCTALHLACRKGNVVLEQLLXGVDVMAR 651
Query: 610 NSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
++ G+TAL Y + EC+ +LL+
Sbjct: 652 DA--------HGNTALTYARQASSQECINVLLQ 676
>gi|239744064 PREDICTED: ArfGAP with GTPase domain, ankyrin repeat
and PH domain 10 [Homo sapiens]
Length = 684
Score = 106 bits (264), Expect = 1e-22
Identities = 78/273 (28%), Positives = 123/273 (45%), Gaps = 18/273 (6%)
Query: 373 RTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKEIISEVQRMTG 432
+T+HF+A +E W+ +Q+ +L + + ++ + + + +Q M G
Sbjct: 419 QTWHFEATTYEERDAWVQAIQSQILASLQSC---KSSKSKSQLTSQSEAMALQSIQNMRG 475
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C DC +P W S NLG+L CIECSGIHR G SR++SL LD + +I
Sbjct: 476 NAHCVDCETQNPKWASLNLGVLMCIECSGIHRSFGTRLSRVRSLELDDWPVELRKVMSSI 535
Query: 493 GNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHADNAAKLHSLCE 552
GN N I E ++ KP+ S ++ +I +KY E+ + + L
Sbjct: 536 GNELANSIWEG--SSQGQTKPSIKSTREEKEWWIRSKYEEKLFLAPLPCTELSLGQQLLR 593
Query: 553 AVKTRDIFGLLQAYADGVDLTEKIPLANGHEPDETALHLAVRS---VDRTSLHIVDFLVQ 609
A D+ + A G E++ G TALHLA R V L VD + +
Sbjct: 594 ATTDEDLQTAILLLAHG--SREEVNETCGEGDGCTALHLACRKGNVVLEQLLXGVDVMAR 651
Query: 610 NSGNLDKQTGKGSTALHYCCLTDNAECLKLLLR 642
++ G+TAL Y + EC+ +LL+
Sbjct: 652 DA--------HGNTALTYARQASSQECINVLLQ 676
>gi|206597513 ArfGAP with RhoGAP domain, ankyrin repeat and PH
domain 1 isoform a [Homo sapiens]
Length = 1205
Score = 95.5 bits (236), Expect = 2e-19
Identities = 63/203 (31%), Positives = 100/203 (49%), Gaps = 26/203 (12%)
Query: 362 EKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTK 421
+++ FDL + R + F A+ E E + W+ +Q + EAL+ T
Sbjct: 249 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS------------------TS 290
Query: 422 EIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVL 481
E+ + N C DCGAP P W S NL ++ C C+G HR LG S+++SL +D
Sbjct: 291 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK 350
Query: 482 GTSELL--LAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKK 539
+E L L +GN N +P ++++P+ S + R+ ++ AKY E +Y R+
Sbjct: 351 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS--SSPSTRRCHLEAKYREGKY-RRY 407
Query: 540 HA--DNAAKL-HSLCEAVKTRDI 559
H N +L +LC AV T D+
Sbjct: 408 HPLFGNQEELDKALCAAVTTTDL 430
Score = 32.3 bits (72), Expect = 2.3
Identities = 13/33 (39%), Positives = 23/33 (69%)
Query: 366 FDLISHDRTYHFQAEDEQECQIWMSVLQNSKEE 398
F++I+++RT+ F+AE + E + WM LQ + E
Sbjct: 143 FEVITNNRTFAFRAESDVERKEWMQALQQAMAE 175
>gi|92091600 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
1 isoform c [Homo sapiens]
Length = 1450
Score = 95.5 bits (236), Expect = 2e-19
Identities = 63/203 (31%), Positives = 100/203 (49%), Gaps = 26/203 (12%)
Query: 362 EKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTK 421
+++ FDL + R + F A+ E E + W+ +Q + EAL+ T
Sbjct: 494 DRRSFDLTTPYRIFSFSADSELEKEQWLEAMQGAIAEALS------------------TS 535
Query: 422 EIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVL 481
E+ + N C DCGAP P W S NL ++ C C+G HR LG S+++SL +D
Sbjct: 536 EVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRK 595
Query: 482 GTSELL--LAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKK 539
+E L L +GN N +P ++++P+ S + R+ ++ AKY E +Y R+
Sbjct: 596 VWTETLIELFLQLGNGAGNRFWAANVPPSEALQPS--SSPSTRRCHLEAKYREGKY-RRY 652
Query: 540 HA--DNAAKL-HSLCEAVKTRDI 559
H N +L +LC AV T D+
Sbjct: 653 HPLFGNQEELDKALCAAVTTTDL 675
Score = 43.5 bits (101), Expect = 0.001
Identities = 41/139 (29%), Positives = 52/139 (37%), Gaps = 31/139 (22%)
Query: 770 SPP-PAQPAAPSTTS--------APPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRS 820
SPP PA P P T+ APP+PPR T + S
Sbjct: 91 SPPVPATPPEPLPTTTEDEGLPAAPPIPPRRSCLPPTCFTTP-----------------S 133
Query: 821 SSDPPAVHPPLPPLRVTSTNPLTPTPP---PP--VAKTPSVMEALSQPSKPAPPGISQIR 875
++ P V PPLP R + + P PP PP + P+ E PS +PP
Sbjct: 134 TAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTKEEESLLPSLSSPPQPQSEE 193
Query: 876 PPPLPPQPPSRLPQKKPAP 894
P PQ P + P P P
Sbjct: 194 PLSTLPQGPPQPPSPPPCP 212
Score = 32.3 bits (72), Expect = 2.3
Identities = 13/33 (39%), Positives = 23/33 (69%)
Query: 366 FDLISHDRTYHFQAEDEQECQIWMSVLQNSKEE 398
F++I+++RT+ F+AE + E + WM LQ + E
Sbjct: 388 FEVITNNRTFAFRAESDVERKEWMQALQQAMAE 420
Score = 30.8 bits (68), Expect = 6.7
Identities = 44/177 (24%), Positives = 59/177 (33%), Gaps = 34/177 (19%)
Query: 829 PPLPPLR-----VTSTNPLTPTPPPPVAKTPSV--MEALSQPSKPAPPG----------- 870
PP+PP R T P T P P + P+ + LS P P G
Sbjct: 115 PPIPPRRSCLPPTCFTTPSTAAPDPVLPPLPAKRHLAELSVPPVPPRTGPPRLLVSLPTK 174
Query: 871 -----ISQIRPPPLP--PQPPSRLPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPL 923
+ + PP P +P S LPQ P P S P P PV L
Sbjct: 175 EEESLLPSLSSPPQPQSEEPLSTLPQGPPQP---PSPPPCPPEIPPKPVRLFPEFDDSDY 231
Query: 924 SNAMVLQPPAPMPRKSQATKLKPKRVKALYNCVADNPDELTFSEGDVIIVDGEEDQE 980
P AP ++ + P RV + SEG+ + D + D+E
Sbjct: 232 DEVPEEGPGAPARVMTKKEEPPPSRVPRAVRVAS------LLSEGEELSGDDQGDEE 282
>gi|21264592 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
2 [Homo sapiens]
Length = 1704
Score = 88.6 bits (218), Expect = 3e-17
Identities = 63/214 (29%), Positives = 105/214 (49%), Gaps = 24/214 (11%)
Query: 363 KKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDDNTGENNIVQELTKE 422
K+ F++I+ R++ F AE E+E Q W+ +Q S E L++ E
Sbjct: 645 KQSFEIITPYRSFSFTAETEKEKQDWIEAVQQSIAETLSDY------------------E 686
Query: 423 IISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDV-L 481
+ ++ N C DC APDP W S NL ++ C +C+G HR LG S+++SL +D +
Sbjct: 687 VAEKIWFNESNRSCADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASI 746
Query: 482 GTSELL-LAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKH 540
++EL+ L IGN N+ L ++ + + S + RK++IT KY E ++ +
Sbjct: 747 WSNELIELFIVIGNKRANDFWAGNLQKDEEL--HMDSPVEKRKNFITQKYKEGKFRKTLL 804
Query: 541 ADNAAK--LHSLCEAVKTRDIFGLLQAYADGVDL 572
A + +LC AV D+ + G D+
Sbjct: 805 ASLTKEELNKALCAAVVKPDVLETMALLFSGADV 838
Score = 32.0 bits (71), Expect = 3.0
Identities = 27/100 (27%), Positives = 53/100 (53%), Gaps = 9/100 (9%)
Query: 308 RNGSLYKKSDGIRKVWQKRKCSVKNGFLTISHGTANRPPAKLNLLTCQ----VKTNPEEK 363
++G L K S ++++QKR VK L+IS+ + ++ V+ + K
Sbjct: 485 KSGWLDKLSPQGKRMFQKRW--VKFDGLSISYYNNEKEMYSKGIIPLSAISTVRVQGDNK 542
Query: 364 KCFDLISHDRTYHFQAEDEQECQIWMSVLQNS-KEEALNN 402
F++++ RT+ F+ E E+E W+S+L N+ K ++L +
Sbjct: 543 --FEVVTTQRTFVFRVEKEEERNDWISILLNALKSQSLTS 580
>gi|21264337 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain
3 [Homo sapiens]
Length = 1544
Score = 81.6 bits (200), Expect = 3e-15
Identities = 61/211 (28%), Positives = 95/211 (45%), Gaps = 28/211 (13%)
Query: 349 LNLLTCQVKTNPEEKKCFDLISHDRTYHFQAEDEQECQIWMSVLQNSKEEALNNAFKGDD 408
+ L C V+ + + FDL++ R + F AE Q W + LQ + E L++
Sbjct: 437 IELQGCSVRET--KSRSFDLLTPHRCFSFTAESGGARQSWAAALQEAVTETLSDY----- 489
Query: 409 NTGENNIVQELTKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGV 468
E+ ++ N C DCG+ P W + NLG++ C +C+G HR LG
Sbjct: 490 -------------EVAEKIWSNRANRQCADCGSSRPDWAAVNLGVVICKQCAGQHRALGS 536
Query: 469 HYSRMQSLTLD--VLGTSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYI 526
S++QSL LD V + L +GN N LP + + +P + R ++I
Sbjct: 537 GISKVQSLKLDTSVWSNEIVQLFIVLGNDRANRFWAGTLPPGEGL--HPDATPGPRGEFI 594
Query: 527 TAKYIERRYARKKH---ADNAAKLHSLCEAV 554
+ KY RK H D++ L +LC AV
Sbjct: 595 SRKY-RLGLFRKPHPQYPDHSQLLQALCAAV 624
Score = 31.6 bits (70), Expect = 3.9
Identities = 19/49 (38%), Positives = 23/49 (46%), Gaps = 4/49 (8%)
Query: 846 PPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSRLPQKKPAP 894
PP PV K +V LS P+ PG+S P L SR P+ P P
Sbjct: 91 PPKPVPKPRTVFGGLSGPATTQRPGLS----PALGGPGVSRSPEPSPRP 135
>gi|113204622 stromal membrane-associated GTPase-activating protein
1 isoform A [Homo sapiens]
Length = 467
Score = 79.3 bits (194), Expect = 2e-14
Identities = 43/123 (34%), Positives = 65/123 (52%), Gaps = 9/123 (7%)
Query: 423 IISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLG 482
I+S++ R N C DC A P W S N+G+ CI C+GIHR LGVH SR++S+ LD
Sbjct: 20 ILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWT 79
Query: 483 TSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHAD 542
++ +++GN + E LP E+ +P + D +I +Y +KK+ D
Sbjct: 80 AEQIQCMQDMGNTKARLLYEANLP-ENFRRP--------QTDQAVEFFIRDKYEKKKYYD 130
Query: 543 NAA 545
A
Sbjct: 131 KNA 133
>gi|21264558 stromal membrane-associated GTPase-activating protein 1
isoform B [Homo sapiens]
Length = 440
Score = 79.3 bits (194), Expect = 2e-14
Identities = 43/123 (34%), Positives = 65/123 (52%), Gaps = 9/123 (7%)
Query: 423 IISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLG 482
I+S++ R N C DC A P W S N+G+ CI C+GIHR LGVH SR++S+ LD
Sbjct: 20 ILSKLLREEDNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWT 79
Query: 483 TSELLLAKNIGNAGFNEIMECCLPAEDSVKPNPGSDMNARKDYITAKYIERRYARKKHAD 542
++ +++GN + E LP E+ +P + D +I +Y +KK+ D
Sbjct: 80 AEQIQCMQDMGNTKARLLYEANLP-ENFRRP--------QTDQAVEFFIRDKYEKKKYYD 130
Query: 543 NAA 545
A
Sbjct: 131 KNA 133
>gi|28416436 ADP-ribosylation factor GTPase activating protein 1
isoform b [Homo sapiens]
Length = 414
Score = 78.2 bits (191), Expect = 4e-14
Identities = 38/83 (45%), Positives = 53/83 (63%)
Query: 420 TKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLD 479
T++++ EV+ N+VC +CGA +P W+S GI C+ECSG HR LGVH S ++S+T+D
Sbjct: 6 TRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMD 65
Query: 480 VLGTSELLLAKNIGNAGFNEIME 502
EL K GNA F E +E
Sbjct: 66 KWKDIELEKMKAGGNAKFREFLE 88
>gi|8922652 ADP-ribosylation factor GTPase activating protein 1
isoform a [Homo sapiens]
Length = 406
Score = 78.2 bits (191), Expect = 4e-14
Identities = 38/83 (45%), Positives = 53/83 (63%)
Query: 420 TKEIISEVQRMTGNDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLD 479
T++++ EV+ N+VC +CGA +P W+S GI C+ECSG HR LGVH S ++S+T+D
Sbjct: 6 TRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMD 65
Query: 480 VLGTSELLLAKNIGNAGFNEIME 502
EL K GNA F E +E
Sbjct: 66 KWKDIELEKMKAGGNAKFREFLE 88
>gi|23943872 small ArfGAP2 [Homo sapiens]
Length = 429
Score = 75.9 bits (185), Expect = 2e-13
Identities = 39/103 (37%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 433 NDVCCDCGAPDPTWLSTNLGILTCIECSGIHRELGVHYSRMQSLTLDVLGTSELLLAKNI 492
N C DC + P W S N+G+ CI C+GIHR LGVH SR++S+ LD ++ + +
Sbjct: 25 NKFCADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEM 84
Query: 493 GNAGFNEIMECCLPAEDSVKP--NPGSDMNARKDYITAKYIER 533
GN N + E LP E +P +P + R Y KY++R
Sbjct: 85 GNGKANRLYEAYLP-ETFRRPQIDPAVEGFIRDKYEKKKYMDR 126
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.131 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,448,913
Number of Sequences: 37866
Number of extensions: 2380379
Number of successful extensions: 32631
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 752
Number of HSP's successfully gapped in prelim test: 1527
Number of HSP's that attempted gapping in prelim test: 13651
Number of HSP's gapped (non-prelim): 10540
length of query: 1006
length of database: 18,247,518
effective HSP length: 112
effective length of query: 894
effective length of database: 14,006,526
effective search space: 12521834244
effective search space used: 12521834244
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.