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Search of human proteins with 42822874
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
(461 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 926 0.0
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 926 0.0
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 926 0.0
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 926 0.0
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 926 0.0
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 926 0.0
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 926 0.0
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 926 0.0
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 283 2e-76
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 237 2e-62
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 234 2e-61
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 225 6e-59
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 225 6e-59
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 202 5e-52
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 200 3e-51
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 199 6e-51
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 194 1e-49
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 191 9e-49
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 184 1e-46
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 179 6e-45
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 175 9e-44
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 161 1e-39
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 154 2e-37
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 145 8e-35
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 144 1e-34
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 141 1e-33
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 141 1e-33
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 141 1e-33
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 130 2e-30
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 130 2e-30
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 926 bits (2392), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 926 bits (2392), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 926 bits (2392), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 926 bits (2392), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 926 bits (2392), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 926 bits (2392), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 926 bits (2392), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 926 bits (2392), Expect = 0.0
Identities = 461/461 (100%), Positives = 461/461 (100%)
Query: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1 MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 283 bits (724), Expect = 2e-76
Identities = 150/353 (42%), Positives = 214/353 (60%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
L +A + +++AL NP L EL+L N LG GV + QGL+ P+CK+Q L L+ C ++
Sbjct: 697 LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
+ C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +QL C L + +C
Sbjct: 757 SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+ C +T+ C +L
Sbjct: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
Query: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + C + + C L V
Sbjct: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936
Query: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
L+A +L+EL L+ N+LGD G LL E L P C+L+ LW+ SC TA C + L
Sbjct: 937 LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996
Query: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
N+ L +L ++NN L D GVR LC+ L PG LRVLWL D++ + S LAA
Sbjct: 997 NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAA 1049
Score = 261 bits (667), Expect = 9e-70
Identities = 140/355 (39%), Positives = 206/355 (58%)
Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
L++ L T P L EL L N LG G++LLC+GL P C+L+ L+L+ C +S+++CE L++
Sbjct: 705 LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764
Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
L A + + +S N + G+ +LC+GL+ C+L+ ++L C + S C+++ ++
Sbjct: 765 ALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLG 824
Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
+ L EL L N L D+G+ LC GL HP RLRTLW+ C +TA C +L L +
Sbjct: 825 TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 884
Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
SL+EL L+ NELGD G LLCE L P C+L++L + C +A C S VL N L
Sbjct: 885 SLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLR 944
Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
EL +S N L D G+ L +GL P L+ LWL C ++ +C +L TL N +L +L
Sbjct: 945 ELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLY 1004
Query: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
L+NN LGD G+ L + + PGC L L L+ + ++ RL AL KP L +
Sbjct: 1005 LTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
Score = 237 bits (604), Expect = 2e-62
Identities = 121/290 (41%), Positives = 176/290 (60%)
Query: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Q +RL C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q +
Sbjct: 745 QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804
Query: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
L+ C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+
Sbjct: 805 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864
Query: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
C L+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L C
Sbjct: 865 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICR 924
Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
+ S C L ++ + +LREL L N LGD G+ L GL HP+ RL+ LW+ CG+TA
Sbjct: 925 LGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA 984
Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
K C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 985 KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034
Score = 215 bits (547), Expect = 8e-56
Identities = 114/278 (41%), Positives = 161/278 (57%)
Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
A E LA+ L P+ EL++ N + GV++LCQGL+ C+L+ L+L+ C ++S C
Sbjct: 700 AYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSAC 759
Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDL 276
DL + + +L + L N +G GM LC GL HP RL+ + + +C + + C ++
Sbjct: 760 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 819
Query: 277 CRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
VL L EL L GN L D G RLLC+ L P C+L +LW+K C TAA C +S
Sbjct: 820 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 879
Query: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
L+ N+ L EL +S N L D GV LC+GL P L+ L L C + ++C L+ L A
Sbjct: 880 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQA 939
Query: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
NH+LRELDLS N LGD G+ L E ++ P C L++L L
Sbjct: 940 NHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
Score = 193 bits (490), Expect = 3e-49
Identities = 101/238 (42%), Positives = 151/238 (63%), Gaps = 2/238 (0%)
Query: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 798 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 857
Query: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 858 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 917
Query: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
L+L C L +A+CE L+ VL+A + +EL +S ND+ + G+ +L +GL+ C+L+ L L
Sbjct: 918 LRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977
Query: 207 ESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
+SCG+T+ C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 978 DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035
Score = 105 bits (262), Expect = 9e-23
Identities = 65/170 (38%), Positives = 95/170 (55%), Gaps = 4/170 (2%)
Query: 5 IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
++ LD+ EL D L L+ + Q +RL C L A C+ +S L+ N L E
Sbjct: 886 LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRE 945
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
L+L N+LGD G+ + +GLQ P+C++QKL L +C LT C L TL TL +L+L
Sbjct: 946 LDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYL 1005
Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
++N LGD G++LLC+ L P C+L L L L+ + LA++ KP
Sbjct: 1006 TNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/51 (41%), Positives = 27/51 (52%)
Query: 384 DSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
D+ LAA L N +L EL L N LG G+ L + +R P C L+ L L
Sbjct: 699 DAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRL 749
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 237 bits (604), Expect = 2e-62
Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)
Query: 28 QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
+ C VV L D L E + +D S L +P L +L+L S+ L + + + L+ P+C
Sbjct: 751 EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810
Query: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
KIQ L +N +T G L + L+ L+L L + +++ CE L P+C LE
Sbjct: 811 KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869
Query: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
L+L+ C L+ A ++ +L P K L+++ N + + GV L L+ S C L+ L
Sbjct: 870 SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929
Query: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
LE CG+T+ C+ L + S SL L L +N LG+ G+ LC + P L+ L + +
Sbjct: 930 LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989
Query: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
C + GCG L L L LSL+ N + D G +LLCE + EP C L+ L + C
Sbjct: 990 CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049
Query: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
TAACC S V++++R L L +++N L D GV LC+GL Q SVL L L C ++
Sbjct: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109
Query: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
C +L+ L N L L+L N G+++L + P L+ + L+ + ++
Sbjct: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169
Query: 446 RLQALEKDKP 455
L+ ++ KP
Sbjct: 1170 LLEEVQLLKP 1179
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 234 bits (596), Expect = 2e-61
Identities = 139/412 (33%), Positives = 213/412 (51%), Gaps = 1/412 (0%)
Query: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
+D+ S L N L EL+L + L ++ + L+ P+CK+QKL L+ GC +
Sbjct: 663 QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721
Query: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
S++L L L L + +GD G++ LCE L P+C+L+ L+LE C+L+ C +++
Sbjct: 722 STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781
Query: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
L L +S N++ + GV++LC+ L+ C LE L LESCG+T C L + S
Sbjct: 782 LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
Query: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
L L L N LGD G+ + L H L++L + C T+ L L +S
Sbjct: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901
Query: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
L L L N L D G +LLC+ P C L+ L + C T ACC +SV+ N L
Sbjct: 902 LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961
Query: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
L + NN L+D GV+ LC L P ++ L L C ++ C L++ L+ N L +++L
Sbjct: 962 LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021
Query: 406 SNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
+ N LG GI++L + ++ P C L+ L L + EE + L+A+ P L
Sbjct: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
Score = 213 bits (543), Expect = 2e-55
Identities = 126/356 (35%), Positives = 195/356 (54%)
Query: 45 CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGV 104
C+DIS++L N L L+L+ +++GD GV + + L+ P CK+Q L L++C LT C
Sbjct: 718 CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777
Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
+S+ L +L L+LS N L D G+QLLCE L P+C LE+L LE C L+ A CE L+
Sbjct: 778 ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837
Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
L + L +++N + + GV+++ L+ + C L++L L C TS + L +
Sbjct: 838 ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897
Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
SL L LGSN L D G+ LC HPS L+ L + C +T C DL V+
Sbjct: 898 HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957
Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
+L+ L L N+L D+G ++LC+ L P C ++ L ++ C T+ CC SS L N+ L+
Sbjct: 958 NLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLI 1017
Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
++ ++ N L G+ +L + L P L+VL L + + L A ++N L
Sbjct: 1018 KMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073
Score = 187 bits (475), Expect = 2e-47
Identities = 110/319 (34%), Positives = 176/319 (55%), Gaps = 4/319 (1%)
Query: 4 DIQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALA 59
++ LD++ ++ D L L+ + Q +RL+ C LT C +IS+AL + +L
Sbjct: 730 NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
Query: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
LNL +N L D GV + + L+ P C +++LSL++C LT AGC LS L + L L
Sbjct: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
L+DN+LGD G++L+ + L QC L+ L L C ++ S E L++ L L + +
Sbjct: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
Query: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
N + + GV++LC + C L+ L+L C +T+ C DL ++ + +LR L LG+N L
Sbjct: 910 NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969
Query: 240 GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
D G+ LC L +P+ ++ L + CG+T+ C DL L + L +++L N LG E
Sbjct: 970 QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029
Query: 300 GARLLCETLLEPGCQLESL 318
G L + L P C+L+ L
Sbjct: 1030 GIVKLYKVLKSPKCKLQVL 1048
Score = 107 bits (268), Expect = 2e-23
Identities = 59/169 (34%), Positives = 92/169 (54%)
Query: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
C T + +S++L N +L L+L SN L D GV + + PSC +Q L L C L
Sbjct: 882 CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941
Query: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
T A C L+S + P L+ L L +N L D G+++LC+ L P C +++L LEYC L++
Sbjct: 942 TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001
Query: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
C+ L+S L ++ ++ N + G+ L + LK C+L+ L L
Sbjct: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
Score = 80.1 bits (196), Expect = 4e-15
Identities = 47/119 (39%), Positives = 68/119 (57%)
Query: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Q + L C LT A C D++S + NP L L+L +N+L D GV + L+ P+C IQ+L
Sbjct: 932 QDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRL 991
Query: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
L+ C LT C LSS L L +++L+ N LG G+ L + L P+C+L+ L L
Sbjct: 992 GLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 225 bits (574), Expect = 6e-59
Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)
Query: 141 QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
QC L CS L+++ C L SVL EL +S+N + + G+RVLC+
Sbjct: 705 QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
Query: 194 LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253
L+ C + L L CG++ + C D+ +++S L EL L N LGD G+ LC GL H
Sbjct: 765 LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
Query: 254 PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313
L+ LW+ C +T+ C DL VL SL L + N LGD G +LCE P C
Sbjct: 825 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
Query: 314 QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373
L+ L + + T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+
Sbjct: 885 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
Query: 374 VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433
VL L +C+++ C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L
Sbjct: 945 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
Query: 434 LYDIYWSEEMEDRLQALEKDKPSLRVI 460
L ++Y++ E + L+ L+++KP L V+
Sbjct: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
Score = 211 bits (537), Expect = 1e-54
Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)
Query: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
V CVL +C L N LT + C L S L T +L EL LSDN LGD G+++
Sbjct: 704 VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
Query: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
LCE L P C + +L L C LS C ++ VL + EL +S+N + + G+R+LC
Sbjct: 761 LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
Query: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
GLK C L+ L L SC +TS C+DL ++++ SL L +G N LGD G+A LC
Sbjct: 821 GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
Query: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
+P L+ L + G+T+ C L VL ++L L L GN LGD+G +LLCE LL P
Sbjct: 881 NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
Query: 313 CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372
C+L+ L + +C+ T+ CC S++L ++ L +L + NN L D GV C+ L Q +L
Sbjct: 941 CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000
Query: 373 RVLWLAD 379
+ L L++
Sbjct: 1001 QNLGLSE 1007
Score = 208 bits (529), Expect = 9e-54
Identities = 113/286 (39%), Positives = 164/286 (57%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
LT + C+ + S L + +L EL+L N LGD G+ + + LQ P C I++L L C L+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
C +S L + L EL LSDN LGD G++LLC GL C L+KL L C L++A C
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ LASVL L V N + ++GV +LC+ K+ C L+ L L + G+TS C L
Sbjct: 845 QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
Query: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
++++ +L L L N LGD G+ LC GLLHP +L+ L + C +T+ C DL +
Sbjct: 905 SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
Query: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
L + +SL++LSL N+LGD G + CE L + C L++L + F
Sbjct: 965 LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010
Score = 182 bits (462), Expect = 6e-46
Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)
Query: 2 SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57
S + LD+ L D L LQ C + RL CGL+ C DIS L N
Sbjct: 740 SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
L EL+L N LGD G+ + GL+ C ++KL L +CCLT A C L+S L T +L
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
Query: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
L++ +N LGD+G+ +LCE +PQC L+KL L L++ C L+SVL + L +
Sbjct: 860 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
Query: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
N + + G+++LC+GL C+L+ L+L++C +TS C DL ++ S SLR+L+LG+N
Sbjct: 920 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
Query: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWE 265
LGD+G+ C L S L+ L + E
Sbjct: 980 DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
Score = 94.0 bits (232), Expect = 3e-19
Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 29 QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
QC + +L + GLT C +SS L N L L LR N LGD G+ + +GL P CK
Sbjct: 883 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942
Query: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 943 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002
Query: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
L L + + L ++ KP ELTV
Sbjct: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 225 bits (574), Expect = 6e-59
Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)
Query: 141 QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
QC L CS L+++ C L SVL EL +S+N + + G+RVLC+
Sbjct: 705 QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
Query: 194 LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253
L+ C + L L CG++ + C D+ +++S L EL L N LGD G+ LC GL H
Sbjct: 765 LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
Query: 254 PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313
L+ LW+ C +T+ C DL VL SL L + N LGD G +LCE P C
Sbjct: 825 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884
Query: 314 QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373
L+ L + + T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+
Sbjct: 885 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944
Query: 374 VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433
VL L +C+++ C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L
Sbjct: 945 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004
Query: 434 LYDIYWSEEMEDRLQALEKDKPSLRVI 460
L ++Y++ E + L+ L+++KP L V+
Sbjct: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031
Score = 211 bits (537), Expect = 1e-54
Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)
Query: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
V CVL +C L N LT + C L S L T +L EL LSDN LGD G+++
Sbjct: 704 VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
Query: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
LCE L P C + +L L C LS C ++ VL + EL +S+N + + G+R+LC
Sbjct: 761 LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
Query: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
GLK C L+ L L SC +TS C+DL ++++ SL L +G N LGD G+A LC
Sbjct: 821 GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880
Query: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
+P L+ L + G+T+ C L VL ++L L L GN LGD+G +LLCE LL P
Sbjct: 881 NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940
Query: 313 CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372
C+L+ L + +C+ T+ CC S++L ++ L +L + NN L D GV C+ L Q +L
Sbjct: 941 CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000
Query: 373 RVLWLAD 379
+ L L++
Sbjct: 1001 QNLGLSE 1007
Score = 208 bits (529), Expect = 9e-54
Identities = 113/286 (39%), Positives = 164/286 (57%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
LT + C+ + S L + +L EL+L N LGD G+ + + LQ P C I++L L C L+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
C +S L + L EL LSDN LGD G++LLC GL C L+KL L C L++A C
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ LASVL L V N + ++GV +LC+ K+ C L+ L L + G+TS C L
Sbjct: 845 QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904
Query: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
++++ +L L L N LGD G+ LC GLLHP +L+ L + C +T+ C DL +
Sbjct: 905 SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964
Query: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
L + +SL++LSL N+LGD G + CE L + C L++L + F
Sbjct: 965 LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010
Score = 182 bits (462), Expect = 6e-46
Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)
Query: 2 SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57
S + LD+ L D L LQ C + RL CGL+ C DIS L N
Sbjct: 740 SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
L EL+L N LGD G+ + GL+ C ++KL L +CCLT A C L+S L T +L
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859
Query: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
L++ +N LGD+G+ +LCE +PQC L+KL L L++ C L+SVL + L +
Sbjct: 860 LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919
Query: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
N + + G+++LC+GL C+L+ L+L++C +TS C DL ++ S SLR+L+LG+N
Sbjct: 920 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979
Query: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWE 265
LGD+G+ C L S L+ L + E
Sbjct: 980 DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007
Score = 94.0 bits (232), Expect = 3e-19
Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 29 QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
QC + +L + GLT C +SS L N L L LR N LGD G+ + +GL P CK
Sbjct: 883 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942
Query: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 943 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002
Query: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
L L + + L ++ KP ELTV
Sbjct: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 202 bits (514), Expect = 5e-52
Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)
Query: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
GLL P R ++L L+ C +S+++CE L++ L A + + +S N + G+ +LC+GL+
Sbjct: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
Query: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
C+L+ ++L C + S C+++ ++ + L EL L N L D+G+ LC GL HP
Sbjct: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
Query: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
RLRTLW+ C +TA C +L L +SL+EL L+ NELGD G LLCE L P C+L
Sbjct: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
Query: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
++L + SC TA C + L N+ L +L ++NN L D GVR LC+ L PG LRVL
Sbjct: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258
Query: 376 WLADCDVSDSSCSSLAA 392
WL D++ + S LAA
Sbjct: 259 WLFGMDLNKMTHSRLAA 275
Score = 199 bits (505), Expect = 6e-51
Identities = 100/233 (42%), Positives = 144/233 (61%)
Query: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
Q+L L+ C ++ + C LS+ L L + LS N +G G+ LLCEGL PQCRL+ +
Sbjct: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Query: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
QL C L + +C+ +ASVL P EL ++ N + + G+R+LCQGL+ C+L L L+
Sbjct: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
Query: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
C +T+ C +L ++ SLREL L N+LGD+G+ LC GL HP+ +L+TL + CG
Sbjct: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
Query: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
+TAK C +L L ++L +L L N LGD G RLLC+ L PGC+L LW+
Sbjct: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
Score = 187 bits (474), Expect = 2e-47
Identities = 92/230 (40%), Positives = 141/230 (61%)
Query: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
L C ++ + C+D+S+AL N L ++L N +G G+ + +GL+ P C++Q + L+
Sbjct: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91
Query: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
C L C ++S L T P L EL L+ N L D GL+LLC+GL P CRL L L+ C L
Sbjct: 92 CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151
Query: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
+AA+C+ LAS L +EL +S N++ + GV +LC+GL+ C+L+ L+L+SCG+T+
Sbjct: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211
Query: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
C +L + +L +L L +N LGD G+ LC L HP +LR LW++
Sbjct: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
Score = 180 bits (456), Expect = 3e-45
Identities = 99/258 (38%), Positives = 141/258 (54%)
Query: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
+ L L+ C ++S C DL + + +L + L N +G GM LC GL HP RL+ +
Sbjct: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Query: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
+ +C + + C ++ VL L EL L GN L D G RLLC+ L P C+L +LW+K
Sbjct: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
Query: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
C TAA C +S L+ N+ L EL +S N L D GV LC+GL P L+ L L C
Sbjct: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
Query: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
++ +C +L TL N +L +L L+NN LGD G+ L + + PGC L L L+ + ++
Sbjct: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
Query: 442 EMEDRLQALEKDKPSLRV 459
RL AL KP L +
Sbjct: 268 MTHSRLAALRVTKPYLDI 285
Score = 157 bits (397), Expect = 2e-38
Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)
Query: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
GLL P R + LW+ C I++ C DL L A ++L + L+GN +G G LLCE L
Sbjct: 21 GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78
Query: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
P C+L+ + ++ C + C +SVL N L+EL ++ N LED G+R LCQGL P
Sbjct: 79 HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138
Query: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
LR LWL C ++ ++C LA+TL N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198
Query: 430 EQLVL 434
+ L L
Sbjct: 199 QTLRL 203
Score = 142 bits (358), Expect = 6e-34
Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)
Query: 29 QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
QC Q+++L C L C++++S L NP L EL+L N L D+G+ + QGL+ P C+
Sbjct: 81 QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140
Query: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
++ L L+ C LT A C L+STL +L+EL LS N LGD G+ LLCEGL P C+L+
Sbjct: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200
Query: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
L+L+ C L+A +CE L L +L ++NN + + GVR+LC+ L C+L L L
Sbjct: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260
Score = 106 bits (264), Expect = 5e-23
Identities = 58/133 (43%), Positives = 82/133 (61%)
Query: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
C LT A C +++S L VN +L EL+L NELGD+GV + +GL+ P+CK+Q L L +C L
Sbjct: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
Query: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
T C L TL TL +L+L++N LGD G++LLC+ L P C+L L L L+
Sbjct: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268
Query: 158 SCEPLASVLRAKP 170
+ LA++ KP
Sbjct: 269 THSRLAALRVTKP 281
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 200 bits (508), Expect = 3e-51
Identities = 102/250 (40%), Positives = 150/250 (60%)
Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
+TS CR L ++++ SL EL L N LGD GM LC L HP +R LW+ CG++
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
+ C D+ VL + + L EL L+ N LGD G RLLC L C L+ LW+ + T+ CC
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCC 844
Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
S SSVL+ N+ L L + N L D G++ LC+GL P L+VL L +C+++ C L
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904
Query: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQAL 450
+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L L ++Y++ E + L+ L
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETL 964
Query: 451 EKDKPSLRVI 460
+++KP L V+
Sbjct: 965 QEEKPELTVV 974
Score = 175 bits (443), Expect = 9e-44
Identities = 99/253 (39%), Positives = 141/253 (55%), Gaps = 3/253 (1%)
Query: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
V CVL +C L N LT + C L S L T +L EL LSDN LGD G+++
Sbjct: 704 VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
Query: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
LCE L P C + +L L C LS C ++ VL + EL +S+N + + G+R+LC
Sbjct: 761 LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820
Query: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
GLK C L+ L L + G+TS C L ++++ +L L L N LGD G+ LC GLL
Sbjct: 821 GLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
Query: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
HP +L+ L + C +T+ C DL +L + +SL++LSL N+LGD G + CE L +
Sbjct: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
Query: 313 CQLESLWVKSCSF 325
C L++L + F
Sbjct: 941 CLLQNLGLSEMYF 953
Score = 163 bits (412), Expect = 3e-40
Identities = 91/246 (36%), Positives = 135/246 (54%), Gaps = 7/246 (2%)
Query: 141 QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
QC L CS L+++ C L SVL EL +S+N + + G+RVLC+
Sbjct: 705 QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764
Query: 194 LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253
L+ C + L L CG++ + C D+ +++S L EL L N LGD G+ LC GL H
Sbjct: 765 LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824
Query: 254 PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313
L+ LW+ G+T+ C L VL ++L L L GN LGD+G +LLCE LL P C
Sbjct: 825 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 884
Query: 314 QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373
+L+ L + +C+ T+ CC S++L ++ L +L + NN L D GV C+ L Q +L+
Sbjct: 885 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 944
Query: 374 VLWLAD 379
L L++
Sbjct: 945 NLGLSE 950
Score = 161 bits (407), Expect = 1e-39
Identities = 88/226 (38%), Positives = 131/226 (57%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
LT + C+ + S L + +L EL+L N LGD G+ + + LQ P C I++L L C L+
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
C +S L + L EL LSDN LGD G++LLC GL C L+KL L L++ C
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCC 844
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
L+SVL + L + N + + G+++LC+GL C+L+ L+L++C +TS C DL
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904
Query: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
++ S SLR+L+LG+N LGD+G+ C L S L+ L + E
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
Score = 143 bits (361), Expect = 3e-34
Identities = 82/209 (39%), Positives = 115/209 (55%), Gaps = 4/209 (1%)
Query: 2 SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57
S + LD+ L D L LQ C + RL CGL+ C DIS L N
Sbjct: 740 SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799
Query: 58 LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
L EL+L N LGD G+ + GL+ C ++KL L N LT C LSS L T L
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 859
Query: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
L+L N LGD G++LLCEGLL P C+L+ L+L+ C+L++ C L+++L + ++L++
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919
Query: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKL 206
NND+ + GV + C+ LK C L+ L L
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948
Score = 92.8 bits (229), Expect = 6e-19
Identities = 58/152 (38%), Positives = 79/152 (51%), Gaps = 3/152 (1%)
Query: 26 LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
LL + + L + GLT C +SS L N L L LR N LGD G+ + +GL P C
Sbjct: 825 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 884
Query: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
K+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 885 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 944
Query: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
L L + + L ++ KP ELTV
Sbjct: 945 NLGLSEMYFNYETKSALETLQEEKP---ELTV 973
Score = 48.1 bits (113), Expect = 2e-05
Identities = 24/58 (41%), Positives = 36/58 (62%)
Query: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
L + ++ S C L + L + SL ELDLS+N LGD G+ L E+++ PGC + +L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWL 777
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 199 bits (505), Expect = 6e-51
Identities = 114/355 (32%), Positives = 175/355 (49%), Gaps = 2/355 (0%)
Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
L S T Q L + + L D L +LC+ L P C+L KL + S+ L
Sbjct: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI--FTSVYFGHDSELFK 679
Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
+ P K L++ ++++ +R LC+ LK C++E L L C ++S+ C D+ ++A
Sbjct: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLA 739
Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
+ L+ L+L N L D GM LC L H L L + C +T+ C + VL +
Sbjct: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799
Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
SL L L N L D G LC L PGC + LW+ C T+ C ++VL N L
Sbjct: 800 SLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859
Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
L++ +N + D GVR+LC L P L L L C ++ + C +AA L+A +LR L+
Sbjct: 860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLN 919
Query: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
L L ++ L E++ P C L+ L L+ + EE + L ++E+ P L +
Sbjct: 920 LDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974
Score = 194 bits (493), Expect = 1e-49
Identities = 113/332 (34%), Positives = 168/332 (50%), Gaps = 2/332 (0%)
Query: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
+++ S N L++ + L D + + + L P CK++KL + G +
Sbjct: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF-GHDSELF 678
Query: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
+ L P L+ L L L + ++ LCE L P C++E+L L C +S+ CE +ASV
Sbjct: 679 KAVLHN-PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737
Query: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
L K L++ N + + G+ +LC+ LK S C LE L L C +TS +C + ++
Sbjct: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797
Query: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
SL L LGSN L D G+A LC L HP +R LW+ C +T+ C D+ VL
Sbjct: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857
Query: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
LK L L NE+GD G R LC L P C+LE L +++C T ACC ++ L + L
Sbjct: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
Query: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
L + L+ V LC+ L P L++L L
Sbjct: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
Score = 179 bits (455), Expect = 4e-45
Identities = 105/324 (32%), Positives = 162/324 (50%), Gaps = 2/324 (0%)
Query: 4 DIQSLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
+ Q LD++ L D A L L Q C++ +L + ++ A+ NP L L
Sbjct: 631 NFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLL 690
Query: 62 NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
+L L + + + L+ P CKI++L L C ++ C ++S L L+ L L
Sbjct: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750
Query: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
+N L D G+ LLCE L C LE+L L YC L++ SC+ ++ VL L + +N
Sbjct: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810
Query: 182 INEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGD 241
+ + GV LC LK C + L L C +TSD+C+D+ ++ L+ L LG N++GD
Sbjct: 811 LEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGD 870
Query: 242 VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGA 301
G+ +LC L HP +L L + C IT C D+ L A ++L+ L+L L +
Sbjct: 871 TGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAV 930
Query: 302 RLLCETLLEPGCQLESLWVKSCSF 325
+LCE L P C L+ L + F
Sbjct: 931 VVLCEALSHPDCALQMLGLHKSGF 954
Score = 103 bits (258), Expect = 3e-22
Identities = 61/185 (32%), Positives = 92/185 (49%)
Query: 38 CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
C LT C IS L + +L+ L+L SN L D GV + L+ P C I++L L C L
Sbjct: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840
Query: 98 TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
T C +++ L L+ L L N +GD G++ LC L P C+LE L L+ C ++ A
Sbjct: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900
Query: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCR 217
C+ +A+ L A + L + ++ V VLC+ L C L+ L L G + +
Sbjct: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960
Query: 218 DLCGI 222
L +
Sbjct: 961 ILMSV 965
Score = 39.3 bits (90), Expect = 0.008
Identities = 32/119 (26%), Positives = 49/119 (41%), Gaps = 4/119 (3%)
Query: 5 IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
+++L + E+ D +L LQ + + + L C +T A C DI++AL L
Sbjct: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917
Query: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
LNL L V + + L P C +Q L L +L S +P L H
Sbjct: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTISH 976
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 194 bits (493), Expect = 1e-49
Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)
Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
+ S T+ +L+ELH+ DN L ++L + L C+L L+L Y S +A+ E L
Sbjct: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683
Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
L L+++ I+ +L L + CQ+ L L C + + C ++ ++
Sbjct: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743
Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
S SLR+L L SN L GM LC LLHP+ L +L + C +T C L RVL
Sbjct: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803
Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
+L++L L N L + G + LL P CQLE L + C F++ C + + V+A N L
Sbjct: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863
Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
L+I +N++EDAG++ LC GL P +L + L +C ++ + C SLA+ L N +L L+
Sbjct: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923
Query: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
L N LG+ G+ +L+ES+ P C+L+ + L + + + L +++ KPSL +S
Sbjct: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
Score = 161 bits (407), Expect = 1e-39
Identities = 95/276 (34%), Positives = 144/276 (52%)
Query: 41 TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
T + +D+ AL N +L L++ + + L P+C+I LSL C L +
Sbjct: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733
Query: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
C ++S L + +L++L LS N L G+ +LC+ LL P C L L L +C L+ C
Sbjct: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793
Query: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
L VL P ++L + N + GV + L CQLE L L C +SD C+ +
Sbjct: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853
Query: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
++A+ LR L +GSNK+ D GM LC GL HP+ L + + EC +T+ C L VL
Sbjct: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913
Query: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
++L+ L+L N LG++G L E+L+ P C L+
Sbjct: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949
Score = 160 bits (404), Expect = 3e-39
Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)
Query: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
++I S +L EL++ N+L + + + L+ SCK++ L L + T +G L
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
Query: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
L +L L ++ + LL + L +P C++ L L C L A+ CE +AS+
Sbjct: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741
Query: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
L + ++LT+S+N + G+ +LC L C L +L L C +T + C L ++
Sbjct: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801
Query: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
+LR+L L N+L + G+ + LL P+ +L L + C ++ C + V+ E
Sbjct: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861
Query: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
L+ L + N++ D G +LLC L P C L ++ ++ C T+ACC +SVL N+ L
Sbjct: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921
Query: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
L + N L + GV +L + L P VL+V+ L
Sbjct: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953
Score = 142 bits (357), Expect = 8e-34
Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)
Query: 8 LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
L I C +S ++ L +L + CQ+ L C L + C++I+S L +L +L L
Sbjct: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753
Query: 64 RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
SN L G++ + L P+C + L L CCLT C L L PTL++L L N
Sbjct: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813
Query: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
L + G+ + LL P C+LE+L L C S+ C+ +A V+ + L + +N I
Sbjct: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873
Query: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
+AG+++LC GL+ C L + LE C +TS CR L ++ + +L L L N LG+ G
Sbjct: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933
Query: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
+A+L L+ P L+ + + G+ + L V K SL LS
Sbjct: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980
Score = 112 bits (281), Expect = 5e-25
Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)
Query: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
DP+ + L YC E + +++ A E+TV + V + C D
Sbjct: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588
Query: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
C L LKL + + R++C + + SLREL + N L +
Sbjct: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648
Query: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
L L H S +LRTL + TA G DL + L SL LS+ +
Sbjct: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
Query: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
LL + L EP CQ+ L + C A+ C +S+L L +L +S+N L G+ LC
Sbjct: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
Query: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
L P L L L C ++++ CS+L LL + +LR+LDL N L + G+L + +
Sbjct: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
Query: 423 RQPGCLLEQLVLYDIYWSEEM 443
P C LE+L L ++S ++
Sbjct: 828 LFPTCQLEELHLSGCFFSSDI 848
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 191 bits (486), Expect = 9e-49
Identities = 99/255 (38%), Positives = 147/255 (57%)
Query: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
L CG++ + C D+ +++S L EL L N LGD G+ LC GL H L+ LW+
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
C +T+ C DL VL SL L + N LGD G +LCE P C L+ L + +
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+VL L +C+++
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L L ++Y++ E +
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 446 RLQALEKDKPSLRVI 460
L+ L+++KP L V+
Sbjct: 960 ALETLQEEKPELTVV 974
Score = 177 bits (449), Expect = 2e-44
Identities = 93/231 (40%), Positives = 137/231 (59%)
Query: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
L CGL+ C DIS L N L EL+L N LGD G+ + GL+ C ++KL L +
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
CCLT A C L+S L T +L L++ +N LGD+G+ +LCE +PQC L+KL L L
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
++ C L+SVL + L + N + + G+++LC+GL C+L+ L+L++C +TS
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
C DL ++ S SLR+L+LG+N LGD+G+ C L S L+ L + E
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
Score = 173 bits (438), Expect = 3e-43
Identities = 98/253 (38%), Positives = 139/253 (54%), Gaps = 3/253 (1%)
Query: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
V CVL +C L C L+ C +S L + L EL LSDN LGD G++L
Sbjct: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
Query: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
LC GL C L+KL L C L++A C+ LASVL L V N + ++GV +LC+
Sbjct: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820
Query: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
K+ C L+ L L + G+TS C L ++++ +L L L N LGD G+ LC GLL
Sbjct: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880
Query: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
HP +L+ L + C +T+ C DL +L + +SL++LSL N+LGD G + CE L +
Sbjct: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940
Query: 313 CQLESLWVKSCSF 325
C L++L + F
Sbjct: 941 CLLQNLGLSEMYF 953
Score = 162 bits (411), Expect = 5e-40
Identities = 88/228 (38%), Positives = 132/228 (57%)
Query: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
C LS C ++ VL + EL +S+N + + G+R+LC GLK C L+ L L SC +
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782
Query: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
TS C+DL ++++ SL L +G N LGD G+A LC +P L+ L + G+T+
Sbjct: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842
Query: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
C L VL ++L L L GN LGD+G +LLCE LL P C+L+ L + +C+ T+ CC
Sbjct: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902
Query: 332 HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
S++L ++ L +L + NN L D GV C+ L Q +L+ L L++
Sbjct: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950
Score = 139 bits (350), Expect = 5e-33
Identities = 72/181 (39%), Positives = 107/181 (59%)
Query: 26 LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
LL + + L C LT A C+D++S L + +L L + N LGD GV + + + P C
Sbjct: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827
Query: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
+QKL L N LT C LSS L T L L+L N LGD G++LLCEGLL P C+L+
Sbjct: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887
Query: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
L+L+ C+L++ C L+++L + ++L++ NND+ + GV + C+ LK C L+ L
Sbjct: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947
Query: 206 L 206
L
Sbjct: 948 L 948
Score = 94.0 bits (232), Expect = 3e-19
Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)
Query: 29 QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
QC + +L + GLT C +SS L N L L LR N LGD G+ + +GL P CK
Sbjct: 826 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 885
Query: 87 IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 886 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 945
Query: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
L L + + L ++ KP ELTV
Sbjct: 946 LGLSEMYFNYETKSALETLQEEKP---ELTV 973
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 184 bits (468), Expect = 1e-46
Identities = 116/355 (32%), Positives = 183/355 (51%), Gaps = 2/355 (0%)
Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
+ S L T L+EL + D+ L ++ C L P CRL+KL + S S S L
Sbjct: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFE 688
Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
VL +PD K L+ + ++ +R LC L ++ L L +C ++ +C L G++
Sbjct: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
+ L L + N+L D G+ LC L P + L L + C ++ + C + +L +
Sbjct: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
S++ L L+ N L DEG + LCE L P C L+SL + C TAA C +S L N+ L
Sbjct: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
LQI N + D GV+ LC+ L L +L L +C ++ + C LA+ L + +L++L+
Sbjct: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
Query: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
L+ N L G++ L E++R P C L+ L L + EE + L A E+ P+L +
Sbjct: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
Score = 177 bits (450), Expect = 1e-44
Identities = 117/357 (32%), Positives = 175/357 (49%), Gaps = 2/357 (0%)
Query: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
I S L + L EL ++ + L + L+ PSC++QKL + N +G +L
Sbjct: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV-LLFE 688
Query: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
L P L+ L + L ++ LC+ L P +++L L C LS CE LA +L
Sbjct: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
Query: 168 AKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKA 227
L VS N + + GV +LC+ L L L L C ++ C + ++
Sbjct: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
Query: 228 SLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLK 287
S+R L L +N L D G+ LC L HP L +L + +C ITA GC DL L + ++LK
Sbjct: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
Query: 288 ELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
L + NE+GD G +LLC L C+LE L ++ C T+ CC +SVL ++ L +L
Sbjct: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
Query: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
++ N L+ GV LC+ L P L+VL L D + + + L A N +L D
Sbjct: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
Score = 167 bits (423), Expect = 2e-41
Identities = 104/330 (31%), Positives = 163/330 (49%), Gaps = 16/330 (4%)
Query: 5 IQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDIS---------SALRVN 55
++ L +Q LS++ + + C +R C L + ++S L
Sbjct: 640 LRELQVQDSTLSESTF------VTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQ 693
Query: 56 PALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTL 115
P L L+ +L + + L P+ +++L+L NC L+ C VL+ L L
Sbjct: 694 PDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKL 753
Query: 116 QELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKEL 175
L++S N L D G+ LLCE L P L L L +C LS CE ++ +L + L
Sbjct: 754 TYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYL 812
Query: 176 TVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALG 235
+S N + + G++ LC+ LK C L++L L C +T+ C DL + S +L+ L +G
Sbjct: 813 DLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIG 872
Query: 236 SNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE 295
N++GDVG+ LC L H RL L + ECG+T+ C DL VL ++L++L+L N
Sbjct: 873 CNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNT 932
Query: 296 LGDEGARLLCETLLEPGCQLESLWVKSCSF 325
L G +LCE L P C L+ L ++ F
Sbjct: 933 LDHTGVVVLCEALRHPECALQVLGLRKTDF 962
Score = 34.3 bits (77), Expect = 0.24
Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 1/116 (0%)
Query: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
++ C H SVL + L ELQ+ ++ L ++ C L P L+ L + + S
Sbjct: 622 YSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSG 681
Query: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWS 440
S L L L+ L + L I L +++ P +++L L + + S
Sbjct: 682 QSV-LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS 736
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 179 bits (453), Expect = 6e-45
Identities = 119/331 (35%), Positives = 167/331 (50%), Gaps = 16/331 (4%)
Query: 4 DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSA---------LRV 54
D+ L I LS A L+ +L C+ + D C L K+IS A LR
Sbjct: 700 DLMGLAINDSFLS----ASLVRIL--CEQIASDTCHLQRVVFKNISPADAHRNLCLALRG 753
Query: 55 NPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
+ + L L+ N+ D+ + + L+ P C ++ L L +C T LS L +
Sbjct: 754 HKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812
Query: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
L ++LSDN L D G +LL L P+C L++L LE C L+ A+C+ LA+VL +
Sbjct: 813 LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872
Query: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
L ++ N I GV+ LC+GL+ C+L+ L L +C +TSD C DL ++ K+SL L L
Sbjct: 873 LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932
Query: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
G N +G GM LC L P LR LW+W C I C DLC L +SL L L N
Sbjct: 933 GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992
Query: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
LG G ++L ETL L +L +K F
Sbjct: 993 PLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023
Score = 171 bits (434), Expect = 1e-42
Identities = 108/338 (31%), Positives = 163/338 (48%), Gaps = 2/338 (0%)
Query: 47 DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106
D+ S N L L + + L V + + + + +C +Q++ +N A L
Sbjct: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRN-LC 748
Query: 107 STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166
LR T+ L L N D LCE L P+C L L L CS + L+ L
Sbjct: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
Query: 167 RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226
+ +S+N++ + G ++L L+ C L+ L LE+C +T NC+DL ++
Sbjct: 808 EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867
Query: 227 ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286
L L L N +G+ G+ LC GL +P +L+TL +W C IT+ GC DL ++L+ K SL
Sbjct: 868 RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927
Query: 287 KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
L L N +G +G + LCE L +P C L LW+ CS C S L+ N+ L+ L
Sbjct: 928 LCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTL 987
Query: 347 QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
+ N L +GV+ L + L LR L L D +D
Sbjct: 988 DLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025
Score = 161 bits (408), Expect = 1e-39
Identities = 108/343 (31%), Positives = 164/343 (47%), Gaps = 2/343 (0%)
Query: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
L L ++D+ L + +++LCE + C L+++ + S + A L LR
Sbjct: 701 LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLCLALRGHKTVTY 759
Query: 175 LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
LT+ ND ++ LC+ L+ C L L L SC T+ DL + SL + L
Sbjct: 760 LTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNL 818
Query: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
N+L D G L L HP L+ L + C +T C DL VL L L LA N
Sbjct: 819 SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKN 878
Query: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLE 354
+G+ G + LCE L P C+L++L + +C T+ C + +L + LL L + N +
Sbjct: 879 PIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIG 938
Query: 355 DAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
G++ LC+ L +P LR LWL C + SC L + L N SL LDL N LG +G
Sbjct: 939 VKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSG 998
Query: 415 ILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
+ L E++ L L L +++E+ L+ +E+ P L
Sbjct: 999 VKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 175 bits (443), Expect = 9e-44
Identities = 112/321 (34%), Positives = 164/321 (51%), Gaps = 9/321 (2%)
Query: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
I S L N L EL+L +++L V + L+ P CK+QKL+ C + VL
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT----CKSVTPEWVLQD 773
Query: 108 TLRTLP---TLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
+ L L L+ S N LG + L+ + L C L+ L LE C+LSAASC+ LA
Sbjct: 774 LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832
Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
L + L + N + + G+++LC L C LE L+L C + + C+ L +
Sbjct: 833 FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892
Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
SL L L N L D G+ LC L P L++L + C T +GCG+L L
Sbjct: 893 QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNH 952
Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
++K L L N+L D+G +LLCE L+P L +L + C+ T ACC H SVL+ ++ L+
Sbjct: 953 NVKILDLGENDLQDDGVKLLCEA-LKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011
Query: 345 ELQISNNRLEDAGVRELCQGL 365
L + N L+ GV+ LC+ L
Sbjct: 1012 NLNLLGNELDTDGVKMLCKAL 1032
Score = 169 bits (429), Expect = 4e-42
Identities = 100/291 (34%), Positives = 159/291 (54%), Gaps = 3/291 (1%)
Query: 29 QCQVVRLDDCGLT-EARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKI 87
+C+V +L +T E +D+ AL+ N L LN SN+LG + V +L+ L+ +C +
Sbjct: 754 RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNL 812
Query: 88 QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
+ L L+ C L+ A C L+ L ++ + L L N L D G++LLC L P+C LE+L
Sbjct: 813 KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872
Query: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
+L +C L+A +C+ L+ L L +S N + + GV+ LC+ L L++L L
Sbjct: 873 ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932
Query: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
C T + C +L ++ +++ L LG N L D G+ LC L P L TL + +C
Sbjct: 933 GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCN 991
Query: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESL 318
+T C L VL + +SL L+L GNEL +G ++LC+ L + C+L+ L
Sbjct: 992 LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042
Score = 150 bits (378), Expect = 3e-36
Identities = 91/263 (34%), Positives = 137/263 (52%), Gaps = 4/263 (1%)
Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD-NCRDLC 220
+ S L + EL +SN+ ++ + V+ LC LK+ C+++ L +S VT + +DL
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKS--VTPEWVLQDLI 775
Query: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
+ + L L SNKLG + + + L H + L+ L + +C ++A C DL L
Sbjct: 776 IALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834
Query: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
+ + + L L N L D+G +LLC L P C LE L + C A C H S L QN
Sbjct: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894
Query: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
R L L +S N L D GV+ LC+ LG+P L+ L L+ C + C LA L NH++
Sbjct: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954
Query: 401 RELDLSNNCLGDAGILQLVESVR 423
+ LDL N L D G+ L E+++
Sbjct: 955 KILDLGENDLQDDGVKLLCEALK 977
Score = 94.7 bits (234), Expect = 2e-19
Identities = 66/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%)
Query: 219 LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL--------WIWECGITA 270
+C + + +L EL L ++KL + LC L +P +++ L W+ +
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQ----- 772
Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
DL L+ L L+ + N+LG L+ + L C L+ L ++ C+ +AA C
Sbjct: 773 ----DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASC 827
Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
+ L + + L + NRL+D G++ LC L P L L L C ++ +C L
Sbjct: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
Query: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEE 442
+ LL N SL L+LS N L D G+ L E++ +P L+ L L ++ E
Sbjct: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939
Score = 38.9 bits (89), Expect = 0.010
Identities = 22/80 (27%), Positives = 44/80 (55%)
Query: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQ 431
L +L + D + +S+ +TL+ N +L ELDLSN+ L + + L +++ P C +++
Sbjct: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759
Query: 432 LVLYDIYWSEEMEDRLQALE 451
L + ++D + AL+
Sbjct: 760 LTCKSVTPEWVLQDLIIALQ 779
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 161 bits (408), Expect = 1e-39
Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 7/317 (2%)
Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
L S T L+ L +++++LG L+ L L PQC+L+KL L + + + + L
Sbjct: 695 LCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDLIG 753
Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
VL + L + + ++ V++LC+ L+ C+L+ L+LE C T DL +
Sbjct: 754 VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQ 813
Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
L+ L L N L E C ++L L I C +T C L LR +
Sbjct: 814 GNGHLKTLILRKNSL------ENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSK 867
Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
L LSLA N L DEGA+ + L C L+ L ++ C T CC S L +N+ L
Sbjct: 868 MLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927
Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
L +S N L+D GV LC+ L P L++L L +C + C ++A+ L N LR LD
Sbjct: 928 SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987
Query: 405 LSNNCLGDAGILQLVES 421
LS N +G GIL L E+
Sbjct: 988 LSKNAIGVYGILTLCEA 1004
Score = 149 bits (375), Expect = 7e-36
Identities = 98/321 (30%), Positives = 151/321 (47%), Gaps = 13/321 (4%)
Query: 46 KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ---NCCLTGAGC 102
+D+ S N L L + ++ LG + + L+ P CK+QKL L+ + L
Sbjct: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
Query: 103 GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
GVL+ L+ L + + ++LLC L P+CRL+ L+LE C + L
Sbjct: 753 GVLTGNQH----LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808
Query: 163 ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
+ L+ K L + N + G L S QLE L +E+C +T C L
Sbjct: 809 GNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERLSIENCNLTQLTCESLASC 862
Query: 223 VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
+ L L+L N L D G + L H L+ L + +C +T C D+ L
Sbjct: 863 LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCK 922
Query: 283 KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
++LK L L+ N L D+G LLCE L P C L+ L +++C FT+ CC +S+L +N+
Sbjct: 923 NKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQH 982
Query: 343 LLELQISNNRLEDAGVRELCQ 363
L L +S N + G+ LC+
Sbjct: 983 LRHLDLSKNAIGVYGILTLCE 1003
Score = 118 bits (295), Expect = 1e-26
Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 7/275 (2%)
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ L SV + LT++N+ + ++ L L+ C+L+ L L T N +DL
Sbjct: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751
Query: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
G++ LR L + ++ + LC L P RL+ L + +C T + DL
Sbjct: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811
Query: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
L+ LK L L N L + GA L QLE L +++C+ T C +S L Q
Sbjct: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865
Query: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHS 399
++ L L ++ N L+D G + + L L+ L L CD++ + C + + L N +
Sbjct: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925
Query: 400 LRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
L+ LDLS N L D G++ L E+++ P C L+ L L
Sbjct: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960
Score = 118 bits (295), Expect = 1e-26
Identities = 72/218 (33%), Positives = 112/218 (51%), Gaps = 6/218 (2%)
Query: 31 QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
Q +RL+DC T D+ + L+ N L L LR N L + G + + ++++L
Sbjct: 791 QCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERL 844
Query: 91 SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
S++NC LT C L+S LR L L L++N L D G + + L +C L++L L
Sbjct: 845 SIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLR 904
Query: 151 YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
C L+ C+ + S L K L +S N + + GV +LC+ LK+ C L+ L+LE+C
Sbjct: 905 KCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCL 964
Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELC 248
TS C+ + ++ LR L L N +G G+ LC
Sbjct: 965 FTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLC 1002
Score = 107 bits (266), Expect = 3e-23
Identities = 60/176 (34%), Positives = 92/176 (52%)
Query: 29 QCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQ 88
Q + + +++C LT+ C+ ++S LR + L L+L N L D G + L C +Q
Sbjct: 840 QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQ 899
Query: 89 KLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQ 148
+L L+ C LT C + S L TL+ L LS N L D G+ LLCE L +P C L+ L+
Sbjct: 900 RLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILE 959
Query: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEAL 204
LE C ++ C+ +AS+LR + L +S N I G+ LC+ + E +
Sbjct: 960 LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015
Score = 74.3 bits (181), Expect = 2e-13
Identities = 47/126 (37%), Positives = 62/126 (49%)
Query: 20 WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
W L L Q + L C LT C+D+ SAL N L L+L N L D GV + +
Sbjct: 888 WNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEA 947
Query: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
L+ P C +Q L L+NC T C ++S LR L+ L LS N +G G+ LCE
Sbjct: 948 LKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSS 1007
Query: 140 PQCRLE 145
+ R E
Sbjct: 1008 QKKREE 1013
Score = 29.6 bits (65), Expect = 6.0
Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 1/102 (0%)
Query: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
SV A N L L ++N+ L ++ L L P L+ L L + S L L
Sbjct: 697 SVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVN-STMLNQDLIGVL 755
Query: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
N LR L++ + + + L +R P C L+ L L D
Sbjct: 756 TGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLED 797
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 154 bits (388), Expect = 2e-37
Identities = 78/195 (40%), Positives = 119/195 (61%)
Query: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
CG++ + C D+ VL + + L EL L+ N LGD G RLLC L C L+ LW+ +
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782
Query: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
T+ CCS SSVL+ N+ L L + N L D G++ LC+GL P L+VL L +C+++
Sbjct: 783 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842
Query: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
C L+ L ++ SLR+L L NN LGD G++ E ++Q CLL+ L L ++Y++ E +
Sbjct: 843 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 902
Query: 446 RLQALEKDKPSLRVI 460
L+ L+++KP L V+
Sbjct: 903 ALETLQEEKPELTVV 917
Score = 138 bits (348), Expect = 9e-33
Identities = 72/172 (41%), Positives = 102/172 (59%)
Query: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
L CGL+ C DIS L N L EL+L N LGD G+ + GL+ C ++KL L N
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
LT C LSS L T L L+L N LGD G++LLCEGLL P C+L+ L+L+ C+L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
++ C L+++L + ++L++ NND+ + GV + C+ LK C L+ L L
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891
Score = 129 bits (324), Expect = 6e-30
Identities = 68/174 (39%), Positives = 101/174 (58%)
Query: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
L CG++ + C D+ +++S L EL L N LGD G+ LC GL H L+ LW+
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
G+T+ C L VL ++L L L GN LGD+G +LLCE LL P C+L+ L + +C+
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
T+ CC S++L ++ L +L + NN L D GV C+ L Q +L+ L L++
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 893
Score = 126 bits (317), Expect = 4e-29
Identities = 66/174 (37%), Positives = 100/174 (57%)
Query: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
C LS C ++ VL + EL +S+N + + G+R+LC GLK C L+ L L + G+
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782
Query: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
TS C L ++++ +L L L N LGD G+ LC GLLHP +L+ L + C +T+
Sbjct: 783 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842
Query: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
C DL +L + +SL++LSL N+LGD G + CE L + C L++L + F
Sbjct: 843 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 896
Score = 126 bits (316), Expect = 5e-29
Identities = 73/193 (37%), Positives = 106/193 (54%), Gaps = 3/193 (1%)
Query: 73 VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
V CVL +C L C L+ C +S L + L EL LSDN LGD G++L
Sbjct: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
Query: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
LC GL C L+KL L L++ C L+SVL + L + N + + G+++LC+
Sbjct: 761 LCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 820
Query: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
GL C+L+ L+L++C +TS C DL ++ S SLR+L+LG+N LGD+G+ C L
Sbjct: 821 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 880
Query: 253 HPSSRLRTLWIWE 265
S L+ L + E
Sbjct: 881 QQSCLLQNLGLSE 893
Score = 92.8 bits (229), Expect = 6e-19
Identities = 58/152 (38%), Positives = 79/152 (51%), Gaps = 3/152 (1%)
Query: 26 LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
LL + + L + GLT C +SS L N L L LR N LGD G+ + +GL P C
Sbjct: 768 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 827
Query: 86 KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
K+Q L L NC LT C LS+ L + +L++L L +N LGD G+ + CE L C L+
Sbjct: 828 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 887
Query: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
L L + + L ++ KP ELTV
Sbjct: 888 NLGLSEMYFNYETKSALETLQEEKP---ELTV 916
Score = 41.6 bits (96), Expect = 0.002
Identities = 23/58 (39%), Positives = 32/58 (55%)
Query: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
L C +S C ++ L +N L ELDLS+N LGD GI L ++ C L++L L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 777
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 145 bits (366), Expect = 8e-35
Identities = 102/359 (28%), Positives = 173/359 (48%), Gaps = 7/359 (1%)
Query: 102 CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
C + SS L+ L + + L D+ +++LC+ + C L+K++++ + A +
Sbjct: 668 CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723
Query: 162 LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
+ + K LT++ + + + +LC L++ C L+ L+L T + +
Sbjct: 724 CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782
Query: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
++ + SL+ L L +N L D G L + P L+ L + C +T C DL VL
Sbjct: 783 YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842
Query: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
+ L L LA N +GD G + LCE L P C+L++L ++ CS T C + S L +
Sbjct: 843 VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902
Query: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
L L +S N++ G+ LCQ L P L+ L L C + C L + LL+N L
Sbjct: 903 CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961
Query: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
LDL N L +GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 962 ETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020
Score = 119 bits (299), Expect = 4e-27
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808
Query: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Query: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927
Query: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 928 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 987
Query: 256 SRLRTL 261
L+ L
Sbjct: 988 GSLKIL 993
Score = 118 bits (296), Expect = 1e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815
Query: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875
Query: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934
Query: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 935 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 994
Query: 320 VKS 322
+K+
Sbjct: 995 LKT 997
Score = 91.3 bits (225), Expect = 2e-18
Identities = 74/275 (26%), Positives = 116/275 (42%), Gaps = 58/275 (21%)
Query: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI-------------- 263
D C + +S ++L+ L + + L D + LC + + L+ + I
Sbjct: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCL 725
Query: 264 ------------------WE---------------CGITAKGCGDLCR----------VL 280
WE C + G C VL
Sbjct: 726 AFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVL 785
Query: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
+A +SLK L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL +
Sbjct: 786 KANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVS 845
Query: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
+ L L ++ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL
Sbjct: 846 KKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSL 905
Query: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLY 435
LDLS N + G+ L +++ P C L+ L L+
Sbjct: 906 TNLDLSINQIA-RGLWILCQALENPNCNLKHLRLW 939
Score = 48.9 bits (115), Expect = 1e-05
Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)
Query: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
LR+L +W D C + + +LK L + + L D R+LC+ + C L+
Sbjct: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708
Query: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
+ +K+ + A F + L L ++ + E + LC L L+ L
Sbjct: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767
Query: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
L + + L AN SL+ L LS N L D G + L +++ +P L+ L L
Sbjct: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 144 bits (364), Expect = 1e-34
Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 3/346 (0%)
Query: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
L+ L + + L D+ +++LC+ + C L+K++++ + A + + + K
Sbjct: 649 LKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLTH 707
Query: 175 LTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELA 233
LT++ + + + +LC L++ C L+ L+L T + + ++ + SL+ L
Sbjct: 708 LTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLR 767
Query: 234 LGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAG 293
L +N L D G L + P L+ L + C +T C DL VL + L L LA
Sbjct: 768 LSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAK 827
Query: 294 NELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRL 353
N +GD G + LCE L P C+L++L ++ CS T C + S L + L L +S N++
Sbjct: 828 NPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI 887
Query: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
G+ LCQ L P L+ L L C + C L + LL+N L LDL N L +
Sbjct: 888 A-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKS 946
Query: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
GI++L +RQ L+ L L + E++ L+ +++ P L +
Sbjct: 947 GIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992
Score = 121 bits (303), Expect = 2e-27
Identities = 88/267 (32%), Positives = 134/267 (50%), Gaps = 5/267 (1%)
Query: 171 DFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGIVASKASL 229
+ K L V + ++++ VR+LC + S C L+ K+E VT D RD C K +L
Sbjct: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLAFIGKKTL 705
Query: 230 RELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
L L G + M LC L + L+ L + T + + VL+A +SLK
Sbjct: 706 THLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKH 765
Query: 289 LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQI 348
L L+ N L DEGA LL +T+ P L+ L +++C T A C ++VL ++ L L +
Sbjct: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825
Query: 349 SNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNN 408
+ N + D GV+ LC+GL P L+ L L C ++ C L+ L SL LDLS N
Sbjct: 826 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 885
Query: 409 CLGDAGILQLVESVRQPGCLLEQLVLY 435
+ G+ L +++ P C L+ L L+
Sbjct: 886 QIA-RGLWILCQALENPNCNLKHLRLW 911
Score = 119 bits (299), Expect = 4e-27
Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 26 LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
+L C ++R C L T + + L+ N +L L L +N L D G
Sbjct: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780
Query: 76 VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
+ + + P +Q LSL+NC LT A C L++ L L L L+ N +GD G++ LCE
Sbjct: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840
Query: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
GL P C+L+ L L+ CS++ C L+ L+ L +S N I G+ +LCQ L+
Sbjct: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899
Query: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
+ C L+ L+L SC + C+ L + S L L LG N L G+ +L L +
Sbjct: 900 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 959
Query: 256 SRLRTL 261
L+ L
Sbjct: 960 GSLKIL 965
Score = 118 bits (296), Expect = 1e-26
Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)
Query: 80 LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
L+ C +Q L L C T L+ +L+ L LS N+L D G LL + +
Sbjct: 728 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 787
Query: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
P+ L+ L LE C L+ ASC+ LA+VL L ++ N I + GV+ LC+GL C
Sbjct: 788 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 847
Query: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
+L+ L L+ C +T CR L + SL L L N++ G+ LC L +P+ L+
Sbjct: 848 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 906
Query: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
L +W C + C L L + + L+ L L N L G L L + L+ L
Sbjct: 907 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 966
Query: 320 VKS 322
+K+
Sbjct: 967 LKT 969
Score = 42.4 bits (98), Expect = 9e-04
Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 2/154 (1%)
Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
+ +LK L + + L D R+LC+ + C L+ + +K+ + A F +
Sbjct: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTA-YRDFCLAFIGKK 703
Query: 342 FLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
L L ++ + E + LC L L+ L L + + L AN SL
Sbjct: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763
Query: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
+ L LS N L D G + L +++ +P L+ L L
Sbjct: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 141 bits (355), Expect = 1e-33
Identities = 79/186 (42%), Positives = 104/186 (55%)
Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
A+ SL+ELDL N L D G+ L E +R P C L +L L S+EM L+ALE++KP
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
Query: 456 SLRVIS 461
L + S
Sbjct: 980 QLLIFS 985
Score = 130 bits (328), Expect = 2e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 129 bits (325), Expect = 4e-30
Identities = 72/190 (37%), Positives = 109/190 (57%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L L+ ++ + ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 220 CGIVASKASL 229
+ K L
Sbjct: 972 RALEQEKPQL 981
Score = 126 bits (316), Expect = 5e-29
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 122 bits (305), Expect = 9e-28
Identities = 71/182 (39%), Positives = 97/182 (53%)
Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
+SVL+ + L EL + N L+D GVR LC+GL P L L L +SD L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 391 AA 392
A
Sbjct: 972 RA 973
Score = 115 bits (289), Expect = 6e-26
Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)
Query: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
L N L D G++LLCEGL P C+L +L L+ +LS + L ++ + KP
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
Query: 428 LLEQLVL 434
LLE L L
Sbjct: 838 LLETLRL 844
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 141 bits (355), Expect = 1e-33
Identities = 79/186 (42%), Positives = 104/186 (55%)
Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
A+ SL+ELDL N L D G+ L E +R P C L +L L S+EM L+ALE++KP
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
Query: 456 SLRVIS 461
L + S
Sbjct: 980 QLLIFS 985
Score = 130 bits (328), Expect = 2e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 129 bits (325), Expect = 4e-30
Identities = 72/190 (37%), Positives = 109/190 (57%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L L+ ++ + ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 220 CGIVASKASL 229
+ K L
Sbjct: 972 RALEQEKPQL 981
Score = 126 bits (316), Expect = 5e-29
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 122 bits (305), Expect = 9e-28
Identities = 71/182 (39%), Positives = 97/182 (53%)
Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
+SVL+ + L EL + N L+D GVR LC+GL P L L L +SD L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 391 AA 392
A
Sbjct: 972 RA 973
Score = 115 bits (289), Expect = 6e-26
Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)
Query: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
L N L D G++LLCEGL P C+L +L L+ +LS + L ++ + KP
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
Query: 428 LLEQLVL 434
LLE L L
Sbjct: 838 LLETLRL 844
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 141 bits (355), Expect = 1e-33
Identities = 79/186 (42%), Positives = 104/186 (55%)
Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
A+ SL+ELDL N L D G+ L E +R P C L +L L S+EM L+ALE++KP
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
Query: 456 SLRVIS 461
L + S
Sbjct: 980 QLLIFS 985
Score = 130 bits (328), Expect = 2e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 129 bits (325), Expect = 4e-30
Identities = 72/190 (37%), Positives = 109/190 (57%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L L+ ++ + ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 220 CGIVASKASL 229
+ K L
Sbjct: 972 RALEQEKPQL 981
Score = 126 bits (316), Expect = 5e-29
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 122 bits (305), Expect = 9e-28
Identities = 71/182 (39%), Positives = 97/182 (53%)
Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
+SVL+ + L EL + N L+D GVR LC+GL P L L L +SD L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971
Query: 391 AA 392
A
Sbjct: 972 RA 973
Score = 115 bits (289), Expect = 6e-26
Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)
Query: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
L N L D G++LLCEGL P C+L +L L+ +LS + L ++ + KP
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
Query: 428 LLEQLVL 434
LLE L L
Sbjct: 838 LLETLRL 844
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 130 bits (328), Expect = 2e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 129 bits (323), Expect = 7e-30
Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L S +T D
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
Query: 220 CGIVASKASLRELALGSNK 238
+ S +SL+ LGS +
Sbjct: 971 GEMSNSTSSLKRQRLGSER 989
Score = 126 bits (316), Expect = 5e-29
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 121 bits (304), Expect = 1e-27
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432
A+ SL+ELDL N L D G+ L E +R P C L +L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 119 bits (297), Expect = 8e-27
Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)
Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381
+SVL+ + L EL + N L+D GVR LC+GL P SV+ D
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
Query: 382 VSDSSCSSL---------AATLLANHSLRELDLS 406
+S SSL AA+ +A +L+ LD+S
Sbjct: 972 EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
Score = 108 bits (270), Expect = 1e-23
Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)
Query: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
L N L D G++LLCEGL P C+L +L
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 81.6 bits (200), Expect = 1e-15
Identities = 49/124 (39%), Positives = 67/124 (54%)
Query: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
SVL R L EL +S N L + V+ LC+ L +P +L L LA C ++ C LA L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454
AN +L ELDLS N L DAG L + +RQP C L++L L + + L ++
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 455 PSLR 458
PSL+
Sbjct: 922 PSLK 925
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
Query: 428 LLEQLVL 434
LLE L L
Sbjct: 838 LLETLRL 844
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 130 bits (328), Expect = 2e-30
Identities = 70/162 (43%), Positives = 100/162 (61%)
Query: 97 LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
+T A +L S L+ L+EL LS N L + ++ LC+ L P+C LE L+L C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
C+ LA LRA EL +S N + +AG + LCQ L+ C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
+DL ++++ SL+EL L N L DVG+ LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 129 bits (323), Expect = 7e-30
Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)
Query: 40 LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
+T+A + + S L+V L EL+L N L V + + L+ P C ++ L L C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
C L+ LR TL EL LS N+L DAG + LC+ L P C+L++LQL C L++ C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
+ LASVL A P KEL + N++++ GVR+LC+GL+ C+L L S +T D
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970
Query: 220 CGIVASKASLRELALGSNK 238
+ S +SL+ LGS +
Sbjct: 971 GEMSNSTSSLKRQRLGSER 989
Score = 126 bits (316), Expect = 5e-29
Identities = 67/154 (43%), Positives = 91/154 (59%)
Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
L SVL+ + KEL +S N ++ + V+ LC+ L+ C LE L+L CG+T+++C+DL
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
+ + +L EL L N L D G LC L PS +L+ L + CG+T+ C DL VL
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
A SLKEL L N L D G RLLCE L P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953
Score = 121 bits (304), Expect = 1e-27
Identities = 67/157 (42%), Positives = 87/157 (55%)
Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
L VL+ +LKEL L+GN L + LC+TL P C LE+L + C TA C +
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
L N+ L EL +S N L DAG + LCQ L QP L+ L L C ++ C LA+ L
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432
A+ SL+ELDL N L D G+ L E +R P C L +L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 119 bits (297), Expect = 8e-27
Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)
Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
VT + L ++ +L+EL L N L + LC L P L TL + CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
+ C DL LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC T+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381
+SVL+ + L EL + N L+D GVR LC+GL P SV+ D
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971
Query: 382 VSDSSCSSL---------AATLLANHSLRELDLS 406
+S SSL AA+ +A +L+ LD+S
Sbjct: 972 EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005
Score = 108 bits (270), Expect = 1e-23
Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)
Query: 4 DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
+++ LD+ LS + L L++ + +RL CGLT CKD++ LR N L
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868
Query: 60 ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
EL+L N L D G + Q L+ PSCK+Q+L L +C LT C L+S L P+L+EL
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928
Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
L N L D G++LLCEGL P C+L +L
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956
Score = 81.6 bits (200), Expect = 1e-15
Identities = 49/124 (39%), Positives = 67/124 (54%)
Query: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
SVL R L EL +S N L + V+ LC+ L +P +L L LA C ++ C LA L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861
Query: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454
AN +L ELDLS N L DAG L + +RQP C L++L L + + L ++
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921
Query: 455 PSLR 458
PSL+
Sbjct: 922 PSLK 925
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)
Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
P V+ W+ V+D+ L + L +L+ELDLS N L + + L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837
Query: 428 LLEQLVL 434
LLE L L
Sbjct: 838 LLETLRL 844
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.411
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,632,089
Number of Sequences: 37866
Number of extensions: 751481
Number of successful extensions: 2857
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 2008
Number of HSP's gapped (non-prelim): 452
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.