Guide to the Human Genome
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Search of human proteins with 42822866

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
         (461 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]          926   0.0  
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]          926   0.0  
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]          926   0.0  
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]          926   0.0  
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]          926   0.0  
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]          926   0.0  
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]          926   0.0  
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]          926   0.0  
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...   283   2e-76
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]   237   2e-62
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]     234   2e-61
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho...   225   6e-59
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom...   225   6e-59
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho...   202   5e-52
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...   200   3e-51
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]      199   6e-51
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]    194   1e-49
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho...   191   9e-49
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]     184   1e-46
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]       179   6e-45
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...   175   9e-44
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]      161   1e-39
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom...   154   2e-37
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso...   145   8e-35
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof...   144   1e-34
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo...   141   1e-33
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom...   141   1e-33
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom...   141   1e-33
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom...   130   2e-30
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom...   130   2e-30

>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  926 bits (2392), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
           LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
           SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
           DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
           DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
           ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360

Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
           LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420

Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  926 bits (2392), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
           LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
           SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
           DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
           DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
           ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360

Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
           LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420

Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  926 bits (2392), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
           LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
           SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
           DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
           DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
           ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360

Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
           LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420

Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  926 bits (2392), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
           LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
           SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
           DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
           DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
           ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360

Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
           LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420

Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461


>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  926 bits (2392), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
           LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
           SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
           DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
           DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
           ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360

Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
           LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420

Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461


>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  926 bits (2392), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
           LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
           SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
           DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
           DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
           ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360

Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
           LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420

Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461


>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  926 bits (2392), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
           LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
           SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
           DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
           DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
           ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360

Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
           LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420

Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461


>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score =  926 bits (2392), Expect = 0.0
 Identities = 461/461 (100%), Positives = 461/461 (100%)

Query: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE
Sbjct: 1   MSLDIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
           LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
           SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240
           DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300
           DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360
           ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE
Sbjct: 301 ARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRE 360

Query: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420
           LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE
Sbjct: 361 LCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVE 420

Query: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS
Sbjct: 421 SVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461


>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
            sapiens]
          Length = 1061

 Score =  283 bits (724), Expect = 2e-76
 Identities = 150/353 (42%), Positives = 214/353 (60%)

Query: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
            L +A  + +++AL  NP L EL+L  N LG  GV  + QGL+ P+CK+Q L L+ C ++ 
Sbjct: 697  LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756

Query: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
            + C  LS+ L     L  + LS N +G  G+ LLCEGL  PQCRL+ +QL  C L + +C
Sbjct: 757  SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816

Query: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
            + +ASVL   P   EL ++ N + + G+R+LCQGL+   C+L  L L+ C +T+  C +L
Sbjct: 817  QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876

Query: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
               ++   SLREL L  N+LGD+G+  LC GL HP+ +L+TL +  C + +  C  L  V
Sbjct: 877  ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV 936

Query: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
            L+A  +L+EL L+ N+LGD G  LL E L  P C+L+ LW+ SC  TA  C +    L  
Sbjct: 937  LQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGI 996

Query: 340  NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
            N+ L +L ++NN L D GVR LC+ L  PG  LRVLWL   D++  + S LAA
Sbjct: 997  NQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAA 1049



 Score =  261 bits (667), Expect = 9e-70
 Identities = 140/355 (39%), Positives = 206/355 (58%)

Query: 105  LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
            L++ L T P L EL L  N LG  G++LLC+GL  P C+L+ L+L+ C +S+++CE L++
Sbjct: 705  LAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSA 764

Query: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
             L A  +   + +S N +   G+ +LC+GL+   C+L+ ++L  C + S  C+++  ++ 
Sbjct: 765  ALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLG 824

Query: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
            +   L EL L  N L D+G+  LC GL HP  RLRTLW+  C +TA  C +L   L   +
Sbjct: 825  TNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQ 884

Query: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
            SL+EL L+ NELGD G  LLCE L  P C+L++L +  C   +A C   S VL  N  L 
Sbjct: 885  SLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLR 944

Query: 345  ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
            EL +S N L D G+  L +GL  P   L+ LWL  C ++  +C +L  TL  N +L +L 
Sbjct: 945  ELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLY 1004

Query: 405  LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
            L+NN LGD G+  L + +  PGC L  L L+ +  ++    RL AL   KP L +
Sbjct: 1005 LTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059



 Score =  237 bits (604), Expect = 2e-62
 Identities = 121/290 (41%), Positives = 176/290 (60%)

Query: 31   QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
            Q +RL  C ++ + C+D+S+AL  N  L  ++L  N +G  G+  + +GL+ P C++Q +
Sbjct: 745  QNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 804

Query: 91   SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
             L+ C L    C  ++S L T P L EL L+ N L D GL+LLC+GL  P CRL  L L+
Sbjct: 805  QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 864

Query: 151  YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
             C L+AA+C+ LAS L      +EL +S N++ + GV +LC+GL+   C+L+ L+L  C 
Sbjct: 865  ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICR 924

Query: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
            + S  C  L  ++ +  +LREL L  N LGD G+  L  GL HP+ RL+ LW+  CG+TA
Sbjct: 925  LGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA 984

Query: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
            K C +L   L   ++L +L L  N LGD G RLLC+ L  PGC+L  LW+
Sbjct: 985  KACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 1034



 Score =  215 bits (547), Expect = 8e-56
 Identities = 114/278 (41%), Positives = 161/278 (57%)

Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
           A  E LA+ L   P+  EL++  N +   GV++LCQGL+   C+L+ L+L+ C ++S  C
Sbjct: 700 AYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSAC 759

Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDL 276
            DL   + +  +L  + L  N +G  GM  LC GL HP  RL+ + + +C + +  C ++
Sbjct: 760 EDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEM 819

Query: 277 CRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSV 336
             VL     L EL L GN L D G RLLC+ L  P C+L +LW+K C  TAA C   +S 
Sbjct: 820 ASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELAST 879

Query: 337 LAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLA 396
           L+ N+ L EL +S N L D GV  LC+GL  P   L+ L L  C +  ++C  L+  L A
Sbjct: 880 LSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQA 939

Query: 397 NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
           NH+LRELDLS N LGD G+  L E ++ P C L++L L
Sbjct: 940 NHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977



 Score =  193 bits (490), Expect = 3e-49
 Identities = 101/238 (42%), Positives = 151/238 (63%), Gaps = 2/238 (0%)

Query: 29   QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
            QC  Q+++L  C L    C++++S L  NP L EL+L  N L D+G+  + QGL+ P C+
Sbjct: 798  QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 857

Query: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
            ++ L L+ C LT A C  L+STL    +L+EL LS N LGD G+ LLCEGL  P C+L+ 
Sbjct: 858  LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 917

Query: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
            L+L  C L +A+CE L+ VL+A  + +EL +S ND+ + G+ +L +GL+   C+L+ L L
Sbjct: 918  LRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWL 977

Query: 207  ESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
            +SCG+T+  C +L   +    +L +L L +N LGD G+  LC  L HP  +LR LW++
Sbjct: 978  DSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 1035



 Score =  105 bits (262), Expect = 9e-23
 Identities = 65/170 (38%), Positives = 95/170 (55%), Gaps = 4/170 (2%)

Query: 5    IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
            ++ LD+   EL D     L   L+    + Q +RL  C L  A C+ +S  L+ N  L E
Sbjct: 886  LRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRE 945

Query: 61   LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
            L+L  N+LGD G+  + +GLQ P+C++QKL L +C LT   C  L  TL    TL +L+L
Sbjct: 946  LDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYL 1005

Query: 121  SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
            ++N LGD G++LLC+ L  P C+L  L L    L+  +   LA++   KP
Sbjct: 1006 TNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTKP 1055



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 21/51 (41%), Positives = 27/51 (52%)

Query: 384 DSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
           D+    LAA L  N +L EL L  N LG  G+  L + +R P C L+ L L
Sbjct: 699 DAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRL 749


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score =  237 bits (604), Expect = 2e-62
 Identities = 142/430 (33%), Positives = 221/430 (51%), Gaps = 3/430 (0%)

Query: 28   QQCQVVRL--DDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
            + C VV L   D  L E + +D  S L  +P L +L+L S+ L +  +  +   L+ P+C
Sbjct: 751  EACPVVPLWMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTC 810

Query: 86   KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
            KIQ L  +N  +T  G   L   +     L+ L+L    L +  +++ CE L  P+C LE
Sbjct: 811  KIQTLMFRNAQIT-PGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLE 869

Query: 146  KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
             L+L+ C L+ A    ++ +L   P  K L+++ N + + GV  L   L+ S C L+ L 
Sbjct: 870  SLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLI 929

Query: 206  LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
            LE CG+T+  C+ L   + S  SL  L L +N LG+ G+  LC  +  P   L+ L + +
Sbjct: 930  LEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQ 989

Query: 266  CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
            C +   GCG L   L     L  LSL+ N + D G +LLCE + EP C L+ L +  C  
Sbjct: 990  CHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHL 1049

Query: 326  TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
            TAACC   S V++++R L  L +++N L D GV  LC+GL Q  SVL  L L  C ++  
Sbjct: 1050 TAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSD 1109

Query: 386  SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
             C +L+  L  N  L  L+L  N     G+++L  +   P   L+ + L+   +  ++  
Sbjct: 1110 CCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRK 1169

Query: 446  RLQALEKDKP 455
             L+ ++  KP
Sbjct: 1170 LLEEVQLLKP 1179


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score =  234 bits (596), Expect = 2e-61
 Identities = 139/412 (33%), Positives = 213/412 (51%), Gaps = 1/412 (0%)

Query: 46   KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
            +D+ S L  N  L EL+L  + L    ++ +   L+ P+CK+QKL L+       GC  +
Sbjct: 663  QDLCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPD-GCQDI 721

Query: 106  SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
            S++L     L  L L  + +GD G++ LCE L  P+C+L+ L+LE C+L+   C  +++ 
Sbjct: 722  STSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNA 781

Query: 166  LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
            L        L +S N++ + GV++LC+ L+   C LE L LESCG+T   C  L   + S
Sbjct: 782  LIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841

Query: 226  KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
               L  L L  N LGD G+  +   L H    L++L +  C  T+     L   L   +S
Sbjct: 842  NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKS 901

Query: 286  LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
            L  L L  N L D G +LLC+    P C L+ L +  C  T ACC   +SV+  N  L  
Sbjct: 902  LTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRS 961

Query: 346  LQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDL 405
            L + NN L+D GV+ LC  L  P   ++ L L  C ++   C  L++ L+ N  L +++L
Sbjct: 962  LDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNL 1021

Query: 406  SNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
            + N LG  GI++L + ++ P C L+ L L    + EE +  L+A+    P L
Sbjct: 1022 TQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073



 Score =  213 bits (543), Expect = 2e-55
 Identities = 126/356 (35%), Positives = 195/356 (54%)

Query: 45   CKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGV 104
            C+DIS++L  N  L  L+L+ +++GD GV  + + L+ P CK+Q L L++C LT   C  
Sbjct: 718  CQDISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLN 777

Query: 105  LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
            +S+ L    +L  L+LS N L D G+QLLCE L  P+C LE+L LE C L+ A CE L+ 
Sbjct: 778  ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837

Query: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
             L +      L +++N + + GV+++   L+ + C L++L L  C  TS +   L   + 
Sbjct: 838  ALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLL 897

Query: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
               SL  L LGSN L D G+  LC    HPS  L+ L +  C +T   C DL  V+    
Sbjct: 898  HNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNP 957

Query: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
            +L+ L L  N+L D+G ++LC+ L  P C ++ L ++ C  T+ CC   SS L  N+ L+
Sbjct: 958  NLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLI 1017

Query: 345  ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
            ++ ++ N L   G+ +L + L  P   L+VL L      + +   L A  ++N  L
Sbjct: 1018 KMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073



 Score =  187 bits (475), Expect = 2e-47
 Identities = 110/319 (34%), Positives = 176/319 (55%), Gaps = 4/319 (1%)

Query: 4    DIQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALA 59
            ++  LD++  ++ D     L   L+    + Q +RL+ C LT   C +IS+AL  + +L 
Sbjct: 730  NLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789

Query: 60   ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
             LNL +N L D GV  + + L+ P C +++LSL++C LT AGC  LS  L +   L  L 
Sbjct: 790  FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849

Query: 120  LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSN 179
            L+DN+LGD G++L+ + L   QC L+ L L  C  ++ S E L++ L        L + +
Sbjct: 850  LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909

Query: 180  NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
            N + + GV++LC   +   C L+ L+L  C +T+  C DL  ++ +  +LR L LG+N L
Sbjct: 910  NWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDL 969

Query: 240  GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDE 299
             D G+  LC  L +P+  ++ L +  CG+T+  C DL   L   + L +++L  N LG E
Sbjct: 970  QDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYE 1029

Query: 300  GARLLCETLLEPGCQLESL 318
            G   L + L  P C+L+ L
Sbjct: 1030 GIVKLYKVLKSPKCKLQVL 1048



 Score =  107 bits (268), Expect = 2e-23
 Identities = 59/169 (34%), Positives = 92/169 (54%)

Query: 38   CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
            C  T    + +S++L  N +L  L+L SN L D GV  +    + PSC +Q L L  C L
Sbjct: 882  CHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVL 941

Query: 98   TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
            T A C  L+S +   P L+ L L +N L D G+++LC+ L  P C +++L LEYC L++ 
Sbjct: 942  TNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSL 1001

Query: 158  SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
             C+ L+S L       ++ ++ N +   G+  L + LK   C+L+ L L
Sbjct: 1002 CCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 47/119 (39%), Positives = 68/119 (57%)

Query: 31   QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
            Q + L  C LT A C D++S +  NP L  L+L +N+L D GV  +   L+ P+C IQ+L
Sbjct: 932  QDLELMGCVLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRL 991

Query: 91   SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQL 149
             L+ C LT   C  LSS L     L +++L+ N LG  G+  L + L  P+C+L+ L L
Sbjct: 992  GLEYCGLTSLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKCKLQVLGL 1050


>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
            sapiens]
          Length = 1036

 Score =  225 bits (574), Expect = 6e-59
 Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)

Query: 141  QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
            QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 705  QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764

Query: 194  LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253
            L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 765  LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824

Query: 254  PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313
                L+ LW+  C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C
Sbjct: 825  LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884

Query: 314  QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373
             L+ L + +   T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+
Sbjct: 885  NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944

Query: 374  VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433
            VL L +C+++   C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L 
Sbjct: 945  VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004

Query: 434  LYDIYWSEEMEDRLQALEKDKPSLRVI 460
            L ++Y++ E +  L+ L+++KP L V+
Sbjct: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031



 Score =  211 bits (537), Expect = 1e-54
 Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)

Query: 73   VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
            V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 704  VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760

Query: 133  LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
            LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 761  LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820

Query: 193  GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
            GLK   C L+ L L SC +TS  C+DL  ++++  SL  L +G N LGD G+A LC    
Sbjct: 821  GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880

Query: 253  HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
            +P   L+ L +   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P 
Sbjct: 881  NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940

Query: 313  CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372
            C+L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L
Sbjct: 941  CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000

Query: 373  RVLWLAD 379
            + L L++
Sbjct: 1001 QNLGLSE 1007



 Score =  208 bits (529), Expect = 9e-54
 Identities = 113/286 (39%), Positives = 164/286 (57%)

Query: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
            LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784

Query: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
              C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L  C L++A C
Sbjct: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844

Query: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
            + LASVL        L V  N + ++GV +LC+  K+  C L+ L L + G+TS  C  L
Sbjct: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904

Query: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
              ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+  C DL  +
Sbjct: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964

Query: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
            L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010



 Score =  182 bits (462), Expect = 6e-46
 Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)

Query: 2    SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57
            S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 740  SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799

Query: 58   LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
            L EL+L  N LGD G+  +  GL+   C ++KL L +CCLT A C  L+S L T  +L  
Sbjct: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859

Query: 118  LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
            L++ +N LGD+G+ +LCE   +PQC L+KL L    L++  C  L+SVL    +   L +
Sbjct: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919

Query: 178  SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
              N + + G+++LC+GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N
Sbjct: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979

Query: 238  KLGDVGMAELCPGLLHPSSRLRTLWIWE 265
             LGD+G+   C  L   S  L+ L + E
Sbjct: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 29   QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
            QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 883  QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942

Query: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
            +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 943  LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002

Query: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
            L L     +  +   L ++   KP   ELTV
Sbjct: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030


>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
            sapiens]
          Length = 1036

 Score =  225 bits (574), Expect = 6e-59
 Identities = 122/327 (37%), Positives = 181/327 (55%), Gaps = 7/327 (2%)

Query: 141  QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
            QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 705  QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764

Query: 194  LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253
            L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 765  LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824

Query: 254  PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313
                L+ LW+  C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C
Sbjct: 825  LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 884

Query: 314  QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373
             L+ L + +   T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+
Sbjct: 885  NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 944

Query: 374  VLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLV 433
            VL L +C+++   C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L 
Sbjct: 945  VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 1004

Query: 434  LYDIYWSEEMEDRLQALEKDKPSLRVI 460
            L ++Y++ E +  L+ L+++KP L V+
Sbjct: 1005 LSEMYFNYETKSALETLQEEKPELTVV 1031



 Score =  211 bits (537), Expect = 1e-54
 Identities = 121/307 (39%), Positives = 173/307 (56%), Gaps = 3/307 (0%)

Query: 73   VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
            V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 704  VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760

Query: 133  LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
            LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 761  LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820

Query: 193  GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
            GLK   C L+ L L SC +TS  C+DL  ++++  SL  L +G N LGD G+A LC    
Sbjct: 821  GLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAK 880

Query: 253  HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
            +P   L+ L +   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P 
Sbjct: 881  NPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPD 940

Query: 313  CQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVL 372
            C+L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L
Sbjct: 941  CKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLL 1000

Query: 373  RVLWLAD 379
            + L L++
Sbjct: 1001 QNLGLSE 1007



 Score =  208 bits (529), Expect = 9e-54
 Identities = 113/286 (39%), Positives = 164/286 (57%)

Query: 40   LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
            LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 725  LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784

Query: 100  AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
              C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L  C L++A C
Sbjct: 785  ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 844

Query: 160  EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
            + LASVL        L V  N + ++GV +LC+  K+  C L+ L L + G+TS  C  L
Sbjct: 845  QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 904

Query: 220  CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
              ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+  C DL  +
Sbjct: 905  SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 964

Query: 280  LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
            L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 965  LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 1010



 Score =  182 bits (462), Expect = 6e-46
 Identities = 103/268 (38%), Positives = 150/268 (55%), Gaps = 4/268 (1%)

Query: 2    SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57
            S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 740  SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799

Query: 58   LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
            L EL+L  N LGD G+  +  GL+   C ++KL L +CCLT A C  L+S L T  +L  
Sbjct: 800  LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTR 859

Query: 118  LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
            L++ +N LGD+G+ +LCE   +PQC L+KL L    L++  C  L+SVL    +   L +
Sbjct: 860  LYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYL 919

Query: 178  SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237
              N + + G+++LC+GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N
Sbjct: 920  RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 979

Query: 238  KLGDVGMAELCPGLLHPSSRLRTLWIWE 265
             LGD+G+   C  L   S  L+ L + E
Sbjct: 980  DLGDLGVMMFCEVLKQQSCLLQNLGLSE 1007



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 29   QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
            QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 883  QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 942

Query: 87   IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
            +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 943  LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 1002

Query: 147  LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
            L L     +  +   L ++   KP   ELTV
Sbjct: 1003 LGLSEMYFNYETKSALETLQEEKP---ELTV 1030


>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
           sapiens]
          Length = 287

 Score =  202 bits (514), Expect = 5e-52
 Identities = 105/257 (40%), Positives = 154/257 (59%), Gaps = 2/257 (0%)

Query: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
           GLL P  R ++L L+ C +S+++CE L++ L A  +   + +S N +   G+ +LC+GL+
Sbjct: 21  GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78

Query: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
              C+L+ ++L  C + S  C+++  ++ +   L EL L  N L D+G+  LC GL HP 
Sbjct: 79  HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138

Query: 256 SRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
            RLRTLW+  C +TA  C +L   L   +SL+EL L+ NELGD G  LLCE L  P C+L
Sbjct: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198

Query: 316 ESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVL 375
           ++L + SC  TA  C +    L  N+ L +L ++NN L D GVR LC+ L  PG  LRVL
Sbjct: 199 QTLRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVL 258

Query: 376 WLADCDVSDSSCSSLAA 392
           WL   D++  + S LAA
Sbjct: 259 WLFGMDLNKMTHSRLAA 275



 Score =  199 bits (505), Expect = 6e-51
 Identities = 100/233 (42%), Positives = 144/233 (61%)

Query: 88  QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
           Q+L L+ C ++ + C  LS+ L     L  + LS N +G  G+ LLCEGL  PQCRL+ +
Sbjct: 28  QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87

Query: 148 QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
           QL  C L + +C+ +ASVL   P   EL ++ N + + G+R+LCQGL+   C+L  L L+
Sbjct: 88  QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147

Query: 208 SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
            C +T+  C +L   ++   SLREL L  N+LGD+G+  LC GL HP+ +L+TL +  CG
Sbjct: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207

Query: 268 ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWV 320
           +TAK C +L   L   ++L +L L  N LGD G RLLC+ L  PGC+L  LW+
Sbjct: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260



 Score =  187 bits (474), Expect = 2e-47
 Identities = 92/230 (40%), Positives = 141/230 (61%)

Query: 35  LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
           L  C ++ + C+D+S+AL  N  L  ++L  N +G  G+  + +GL+ P C++Q + L+ 
Sbjct: 32  LKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRK 91

Query: 95  CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
           C L    C  ++S L T P L EL L+ N L D GL+LLC+GL  P CRL  L L+ C L
Sbjct: 92  CQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRL 151

Query: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
           +AA+C+ LAS L      +EL +S N++ + GV +LC+GL+   C+L+ L+L+SCG+T+ 
Sbjct: 152 TAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAK 211

Query: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIW 264
            C +L   +    +L +L L +N LGD G+  LC  L HP  +LR LW++
Sbjct: 212 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261



 Score =  180 bits (456), Expect = 3e-45
 Identities = 99/258 (38%), Positives = 141/258 (54%)

Query: 202 EALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL 261
           + L L+ C ++S  C DL   + +  +L  + L  N +G  GM  LC GL HP  RL+ +
Sbjct: 28  QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87

Query: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
            + +C + +  C ++  VL     L EL L GN L D G RLLC+ L  P C+L +LW+K
Sbjct: 88  QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147

Query: 322 SCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCD 381
            C  TAA C   +S L+ N+ L EL +S N L D GV  LC+GL  P   L+ L L  C 
Sbjct: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207

Query: 382 VSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSE 441
           ++  +C +L  TL  N +L +L L+NN LGD G+  L + +  PGC L  L L+ +  ++
Sbjct: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267

Query: 442 EMEDRLQALEKDKPSLRV 459
               RL AL   KP L +
Sbjct: 268 MTHSRLAALRVTKPYLDI 285



 Score =  157 bits (397), Expect = 2e-38
 Identities = 83/185 (44%), Positives = 111/185 (60%), Gaps = 2/185 (1%)

Query: 250 GLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLL 309
           GLL P  R + LW+  C I++  C DL   L A ++L  + L+GN +G  G  LLCE L 
Sbjct: 21  GLLQP--RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLR 78

Query: 310 EPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG 369
            P C+L+ + ++ C   +  C   +SVL  N  L+EL ++ N LED G+R LCQGL  P 
Sbjct: 79  HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPV 138

Query: 370 SVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLL 429
             LR LWL  C ++ ++C  LA+TL  N SLRELDLS N LGD G+L L E +R P C L
Sbjct: 139 CRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKL 198

Query: 430 EQLVL 434
           + L L
Sbjct: 199 QTLRL 203



 Score =  142 bits (358), Expect = 6e-34
 Identities = 76/180 (42%), Positives = 110/180 (61%), Gaps = 2/180 (1%)

Query: 29  QC--QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
           QC  Q+++L  C L    C++++S L  NP L EL+L  N L D+G+  + QGL+ P C+
Sbjct: 81  QCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCR 140

Query: 87  IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
           ++ L L+ C LT A C  L+STL    +L+EL LS N LGD G+ LLCEGL  P C+L+ 
Sbjct: 141 LRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQT 200

Query: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
           L+L+ C L+A +CE L   L       +L ++NN + + GVR+LC+ L    C+L  L L
Sbjct: 201 LRLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWL 260



 Score =  106 bits (264), Expect = 5e-23
 Identities = 58/133 (43%), Positives = 82/133 (61%)

Query: 38  CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
           C LT A C +++S L VN +L EL+L  NELGD+GV  + +GL+ P+CK+Q L L +C L
Sbjct: 149 CRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208

Query: 98  TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
           T   C  L  TL    TL +L+L++N LGD G++LLC+ L  P C+L  L L    L+  
Sbjct: 209 TAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKM 268

Query: 158 SCEPLASVLRAKP 170
           +   LA++   KP
Sbjct: 269 THSRLAALRVTKP 281


>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
           sapiens]
          Length = 979

 Score =  200 bits (508), Expect = 3e-51
 Identities = 102/250 (40%), Positives = 150/250 (60%)

Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
           +TS  CR L  ++++  SL EL L  N LGD GM  LC  L HP   +R LW+  CG++ 
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784

Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
           + C D+  VL + + L EL L+ N LGD G RLLC  L    C L+ LW+ +   T+ CC
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCC 844

Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
           S  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+VL L +C+++   C  L
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904

Query: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQAL 450
           +  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L L ++Y++ E +  L+ L
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETL 964

Query: 451 EKDKPSLRVI 460
           +++KP L V+
Sbjct: 965 QEEKPELTVV 974



 Score =  175 bits (443), Expect = 9e-44
 Identities = 99/253 (39%), Positives = 141/253 (55%), Gaps = 3/253 (1%)

Query: 73  VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
           V CVL      +C      L N  LT + C  L S L T  +L EL LSDN LGD G+++
Sbjct: 704 VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760

Query: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
           LCE L  P C + +L L  C LS   C  ++ VL +     EL +S+N + + G+R+LC 
Sbjct: 761 LCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCV 820

Query: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
           GLK   C L+ L L + G+TS  C  L  ++++  +L  L L  N LGD G+  LC GLL
Sbjct: 821 GLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880

Query: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
           HP  +L+ L +  C +T+  C DL  +L + +SL++LSL  N+LGD G  + CE L +  
Sbjct: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940

Query: 313 CQLESLWVKSCSF 325
           C L++L +    F
Sbjct: 941 CLLQNLGLSEMYF 953



 Score =  163 bits (412), Expect = 3e-40
 Identities = 91/246 (36%), Positives = 135/246 (54%), Gaps = 7/246 (2%)

Query: 141 QCRLEKLQLEYCS-------LSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQG 193
           QC L       CS       L+++ C  L SVL       EL +S+N + + G+RVLC+ 
Sbjct: 705 QCVLPSSSHAACSHGLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCET 764

Query: 194 LKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLH 253
           L+   C +  L L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H
Sbjct: 765 LQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKH 824

Query: 254 PSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGC 313
               L+ LW+   G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P C
Sbjct: 825 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 884

Query: 314 QLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLR 373
           +L+ L + +C+ T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L+
Sbjct: 885 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 944

Query: 374 VLWLAD 379
            L L++
Sbjct: 945 NLGLSE 950



 Score =  161 bits (407), Expect = 1e-39
 Identities = 88/226 (38%), Positives = 131/226 (57%)

Query: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
           LT + C+ + S L  + +L EL+L  N LGD G+  + + LQ P C I++L L  C L+ 
Sbjct: 725 LTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSH 784

Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
             C  +S  L +   L EL LSDN LGD G++LLC GL    C L+KL L    L++  C
Sbjct: 785 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCC 844

Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
             L+SVL    +   L +  N + + G+++LC+GL    C+L+ L+L++C +TS  C DL
Sbjct: 845 SALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDL 904

Query: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
             ++ S  SLR+L+LG+N LGD+G+   C  L   S  L+ L + E
Sbjct: 905 STLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950



 Score =  143 bits (361), Expect = 3e-34
 Identities = 82/209 (39%), Positives = 115/209 (55%), Gaps = 4/209 (1%)

Query: 2   SLDIQSLDIQCEELSDARWAELLPLLQQ--CQVVRL--DDCGLTEARCKDISSALRVNPA 57
           S  +  LD+    L D     L   LQ   C + RL    CGL+   C DIS  L  N  
Sbjct: 740 SQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQK 799

Query: 58  LAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQE 117
           L EL+L  N LGD G+  +  GL+   C ++KL L N  LT   C  LSS L T   L  
Sbjct: 800 LVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTH 859

Query: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
           L+L  N LGD G++LLCEGLL P C+L+ L+L+ C+L++  C  L+++L +    ++L++
Sbjct: 860 LYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSL 919

Query: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKL 206
            NND+ + GV + C+ LK   C L+ L L
Sbjct: 920 GNNDLGDLGVMMFCEVLKQQSCLLQNLGL 948



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 58/152 (38%), Positives = 79/152 (51%), Gaps = 3/152 (1%)

Query: 26  LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
           LL   + + L + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P C
Sbjct: 825 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 884

Query: 86  KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
           K+Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+
Sbjct: 885 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 944

Query: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
            L L     +  +   L ++   KP   ELTV
Sbjct: 945 NLGLSEMYFNYETKSALETLQEEKP---ELTV 973



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 24/58 (41%), Positives = 36/58 (62%)

Query: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
           L +  ++ S C  L + L  + SL ELDLS+N LGD G+  L E+++ PGC + +L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWL 777


>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
          Length = 991

 Score =  199 bits (505), Expect = 6e-51
 Identities = 114/355 (32%), Positives = 175/355 (49%), Gaps = 2/355 (0%)

Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
           L S   T    Q L + +  L D  L +LC+ L  P C+L KL   + S+       L  
Sbjct: 622 LCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLI--FTSVYFGHDSELFK 679

Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
            +   P  K L++    ++++ +R LC+ LK   C++E L L  C ++S+ C D+  ++A
Sbjct: 680 AVLHNPHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLA 739

Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
             + L+ L+L  N L D GM  LC  L H    L  L +  C +T+  C  +  VL   +
Sbjct: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799

Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
           SL  L L  N L D G   LC  L  PGC +  LW+  C  T+  C   ++VL  N  L 
Sbjct: 800 SLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLK 859

Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
            L++ +N + D GVR+LC  L  P   L  L L  C ++ + C  +AA L+A  +LR L+
Sbjct: 860 TLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLN 919

Query: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
           L    L    ++ L E++  P C L+ L L+   + EE +  L ++E+  P L +
Sbjct: 920 LDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTI 974



 Score =  194 bits (493), Expect = 1e-49
 Identities = 113/332 (34%), Positives = 168/332 (50%), Gaps = 2/332 (0%)

Query: 46  KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
           +++ S    N     L++ +  L D  +  + + L  P CK++KL   +    G    + 
Sbjct: 620 RELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYF-GHDSELF 678

Query: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
            + L   P L+ L L    L  + ++ LCE L  P C++E+L L  C +S+  CE +ASV
Sbjct: 679 KAVLHN-PHLKLLSLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASV 737

Query: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
           L      K L++  N + + G+ +LC+ LK S C LE L L  C +TS +C  +  ++  
Sbjct: 738 LACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLC 797

Query: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
             SL  L LGSN L D G+A LC  L HP   +R LW+  C +T+  C D+  VL     
Sbjct: 798 SKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGK 857

Query: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
           LK L L  NE+GD G R LC  L  P C+LE L +++C  T ACC   ++ L   + L  
Sbjct: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917

Query: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
           L +    L+   V  LC+ L  P   L++L L
Sbjct: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGL 949



 Score =  179 bits (455), Expect = 4e-45
 Identities = 105/324 (32%), Positives = 162/324 (50%), Gaps = 2/324 (0%)

Query: 4   DIQSLDIQCEELSDARWAELLPLLQQ--CQVVRLDDCGLTEARCKDISSALRVNPALAEL 61
           + Q LD++   L D   A L   L Q  C++ +L    +      ++  A+  NP L  L
Sbjct: 631 NFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFGHDSELFKAVLHNPHLKLL 690

Query: 62  NLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLS 121
           +L    L    +  + + L+ P CKI++L L  C ++   C  ++S L     L+ L L 
Sbjct: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750

Query: 122 DNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNND 181
           +N L D G+ LLCE L    C LE+L L YC L++ SC+ ++ VL        L + +N 
Sbjct: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810

Query: 182 INEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGD 241
           + + GV  LC  LK   C +  L L  C +TSD+C+D+  ++     L+ L LG N++GD
Sbjct: 811 LEDNGVASLCAALKHPGCSIRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGD 870

Query: 242 VGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGA 301
            G+ +LC  L HP  +L  L +  C IT   C D+   L A ++L+ L+L    L  +  
Sbjct: 871 TGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAV 930

Query: 302 RLLCETLLEPGCQLESLWVKSCSF 325
            +LCE L  P C L+ L +    F
Sbjct: 931 VVLCEALSHPDCALQMLGLHKSGF 954



 Score =  103 bits (258), Expect = 3e-22
 Identities = 61/185 (32%), Positives = 92/185 (49%)

Query: 38  CGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCL 97
           C LT   C  IS  L  + +L+ L+L SN L D GV  +   L+ P C I++L L  C L
Sbjct: 781 CCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFL 840

Query: 98  TGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAA 157
           T   C  +++ L     L+ L L  N +GD G++ LC  L  P C+LE L L+ C ++ A
Sbjct: 841 TSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRA 900

Query: 158 SCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCR 217
            C+ +A+ L A    + L +    ++   V VLC+ L    C L+ L L   G   +  +
Sbjct: 901 CCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQK 960

Query: 218 DLCGI 222
            L  +
Sbjct: 961 ILMSV 965



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 32/119 (26%), Positives = 49/119 (41%), Gaps = 4/119 (3%)

Query: 5   IQSLDIQCEELSDARWAELLPLLQ----QCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
           +++L +   E+ D    +L   LQ    + + + L  C +T A C DI++AL     L  
Sbjct: 858 LKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDDIAAALIACKTLRS 917

Query: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
           LNL    L    V  + + L  P C +Q L L           +L S    +P L   H
Sbjct: 918 LNLDWIALDADAVVVLCEALSHPDCALQMLGLHKSGFDEETQKILMSVEEKIPHLTISH 976


>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
          Length = 1033

 Score =  194 bits (493), Expect = 1e-49
 Identities = 119/357 (33%), Positives = 190/357 (53%), Gaps = 1/357 (0%)

Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
           + S   T+ +L+ELH+ DN L     ++L + L    C+L  L+L Y S +A+  E L  
Sbjct: 625 ICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLK 683

Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
            L        L+++   I+     +L   L +  CQ+  L L  C + +  C ++  ++ 
Sbjct: 684 ALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLI 743

Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
           S  SLR+L L SN L   GM  LC  LLHP+  L +L +  C +T   C  L RVL    
Sbjct: 744 SGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSP 803

Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
           +L++L L  N L + G   +   LL P CQLE L +  C F++  C + + V+A N  L 
Sbjct: 804 TLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLR 863

Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
            L+I +N++EDAG++ LC GL  P  +L  + L +C ++ + C SLA+ L  N +L  L+
Sbjct: 864 SLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLN 923

Query: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVIS 461
           L  N LG+ G+ +L+ES+  P C+L+ + L     + + +  L  +++ KPSL  +S
Sbjct: 924 LLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980



 Score =  161 bits (407), Expect = 1e-39
 Identities = 95/276 (34%), Positives = 144/276 (52%)

Query: 41  TEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGA 100
           T +  +D+  AL  N +L  L++    +       +   L  P+C+I  LSL  C L  +
Sbjct: 674 TASGFEDLLKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRAS 733

Query: 101 GCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCE 160
            C  ++S L +  +L++L LS N L   G+ +LC+ LL P C L  L L +C L+   C 
Sbjct: 734 ECEEIASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCS 793

Query: 161 PLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
            L  VL   P  ++L +  N +   GV  +   L    CQLE L L  C  +SD C+ + 
Sbjct: 794 ALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIA 853

Query: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
            ++A+   LR L +GSNK+ D GM  LC GL HP+  L  + + EC +T+  C  L  VL
Sbjct: 854 IVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVL 913

Query: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLE 316
              ++L+ L+L  N LG++G   L E+L+ P C L+
Sbjct: 914 TTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLK 949



 Score =  160 bits (404), Expect = 3e-39
 Identities = 100/332 (30%), Positives = 169/332 (50%), Gaps = 1/332 (0%)

Query: 46  KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVL 105
           ++I S      +L EL++  N+L  +    + + L+  SCK++ L L +   T +G   L
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681

Query: 106 SSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASV 165
              L    +L  L ++   +      LL + L +P C++  L L  C L A+ CE +AS+
Sbjct: 682 LKALARNRSLTYLSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASL 741

Query: 166 LRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVAS 225
           L +    ++LT+S+N +   G+ +LC  L    C L +L L  C +T + C  L  ++  
Sbjct: 742 LISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLF 801

Query: 226 KASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKES 285
             +LR+L L  N+L + G+  +   LL P+ +L  L +  C  ++  C  +  V+   E 
Sbjct: 802 SPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEK 861

Query: 286 LKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLE 345
           L+ L +  N++ D G +LLC  L  P C L ++ ++ C  T+ACC   +SVL  N+ L  
Sbjct: 862 LRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLER 921

Query: 346 LQISNNRLEDAGVRELCQGLGQPGSVLRVLWL 377
           L +  N L + GV +L + L  P  VL+V+ L
Sbjct: 922 LNLLQNHLGNDGVAKLLESLISPDCVLKVVGL 953



 Score =  142 bits (357), Expect = 8e-34
 Identities = 94/287 (32%), Positives = 145/287 (50%), Gaps = 4/287 (1%)

Query: 8   LDIQCEELSDARWAELLPLLQQ--CQVVRLD--DCGLTEARCKDISSALRVNPALAELNL 63
           L I C  +S   ++ L  +L +  CQ+  L    C L  + C++I+S L    +L +L L
Sbjct: 694 LSINCTSISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTL 753

Query: 64  RSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN 123
            SN L   G++ +   L  P+C +  L L  CCLT   C  L   L   PTL++L L  N
Sbjct: 754 SSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVN 813

Query: 124 LLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDIN 183
            L + G+  +   LL P C+LE+L L  C  S+  C+ +A V+      + L + +N I 
Sbjct: 814 RLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIE 873

Query: 184 EAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVG 243
           +AG+++LC GL+   C L  + LE C +TS  CR L  ++ +  +L  L L  N LG+ G
Sbjct: 874 DAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDG 933

Query: 244 MAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELS 290
           +A+L   L+ P   L+ + +   G+  +    L  V   K SL  LS
Sbjct: 934 VAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTVKERKPSLIFLS 980



 Score =  112 bits (281), Expect = 5e-25
 Identities = 93/321 (28%), Positives = 142/321 (44%), Gaps = 23/321 (7%)

Query: 139 DPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSP 198
           DP+     + L YC       E + +++ A     E+TV      +  V + C    D  
Sbjct: 535 DPEKLTHHMPLFYCLYENREEEFVKTIVDA---LMEVTVYLQSDKDMMVSLYCL---DYC 588

Query: 199 CQLEALKLESCGVTSDN----------------CRDLCGIVASKASLRELALGSNKLGDV 242
           C L  LKL    +  +                  R++C +  +  SLREL +  N L  +
Sbjct: 589 CHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNGI 648

Query: 243 GMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGAR 302
               L   L H S +LRTL +     TA G  DL + L    SL  LS+    +      
Sbjct: 649 SERILSKALEHSSCKLRTLKLSYVS-TASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707

Query: 303 LLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELC 362
           LL + L EP CQ+  L +  C   A+ C   +S+L     L +L +S+N L   G+  LC
Sbjct: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767

Query: 363 QGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESV 422
             L  P   L  L L  C ++++ CS+L   LL + +LR+LDL  N L + G+L +   +
Sbjct: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827

Query: 423 RQPGCLLEQLVLYDIYWSEEM 443
             P C LE+L L   ++S ++
Sbjct: 828 LFPTCQLEELHLSGCFFSSDI 848


>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
           sapiens]
          Length = 979

 Score =  191 bits (486), Expect = 9e-49
 Identities = 99/255 (38%), Positives = 147/255 (57%)

Query: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
           L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H    L+ LW+  
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779

Query: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
           C +T+  C DL  VL    SL  L +  N LGD G  +LCE    P C L+ L + +   
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839

Query: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
           T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+VL L +C+++  
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899

Query: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
            C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L L ++Y++ E + 
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959

Query: 446 RLQALEKDKPSLRVI 460
            L+ L+++KP L V+
Sbjct: 960 ALETLQEEKPELTVV 974



 Score =  177 bits (449), Expect = 2e-44
 Identities = 93/231 (40%), Positives = 137/231 (59%)

Query: 35  LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
           L  CGL+   C DIS  L  N  L EL+L  N LGD G+  +  GL+   C ++KL L +
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779

Query: 95  CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
           CCLT A C  L+S L T  +L  L++ +N LGD+G+ +LCE   +PQC L+KL L    L
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839

Query: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
           ++  C  L+SVL    +   L +  N + + G+++LC+GL    C+L+ L+L++C +TS 
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899

Query: 215 NCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
            C DL  ++ S  SLR+L+LG+N LGD+G+   C  L   S  L+ L + E
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950



 Score =  173 bits (438), Expect = 3e-43
 Identities = 98/253 (38%), Positives = 139/253 (54%), Gaps = 3/253 (1%)

Query: 73  VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
           V CVL      +C      L  C L+   C  +S  L +   L EL LSDN LGD G++L
Sbjct: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760

Query: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
           LC GL    C L+KL L  C L++A C+ LASVL        L V  N + ++GV +LC+
Sbjct: 761 LCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCE 820

Query: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
             K+  C L+ L L + G+TS  C  L  ++++  +L  L L  N LGD G+  LC GLL
Sbjct: 821 KAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLL 880

Query: 253 HPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPG 312
           HP  +L+ L +  C +T+  C DL  +L + +SL++LSL  N+LGD G  + CE L +  
Sbjct: 881 HPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQS 940

Query: 313 CQLESLWVKSCSF 325
           C L++L +    F
Sbjct: 941 CLLQNLGLSEMYF 953



 Score =  162 bits (411), Expect = 5e-40
 Identities = 88/228 (38%), Positives = 132/228 (57%)

Query: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
           C LS   C  ++ VL +     EL +S+N + + G+R+LC GLK   C L+ L L SC +
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCL 782

Query: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
           TS  C+DL  ++++  SL  L +G N LGD G+A LC    +P   L+ L +   G+T+ 
Sbjct: 783 TSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSV 842

Query: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
            C  L  VL   ++L  L L GN LGD+G +LLCE LL P C+L+ L + +C+ T+ CC 
Sbjct: 843 CCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902

Query: 332 HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
             S++L  ++ L +L + NN L D GV   C+ L Q   +L+ L L++
Sbjct: 903 DLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 950



 Score =  139 bits (350), Expect = 5e-33
 Identities = 72/181 (39%), Positives = 107/181 (59%)

Query: 26  LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
           LL   + + L  C LT A C+D++S L  + +L  L +  N LGD GV  + +  + P C
Sbjct: 768 LLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQC 827

Query: 86  KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
            +QKL L N  LT   C  LSS L T   L  L+L  N LGD G++LLCEGLL P C+L+
Sbjct: 828 NLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQ 887

Query: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALK 205
            L+L+ C+L++  C  L+++L +    ++L++ NND+ + GV + C+ LK   C L+ L 
Sbjct: 888 VLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLG 947

Query: 206 L 206
           L
Sbjct: 948 L 948



 Score = 94.0 bits (232), Expect = 3e-19
 Identities = 58/151 (38%), Positives = 79/151 (52%), Gaps = 5/151 (3%)

Query: 29  QCQVVRLD--DCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCK 86
           QC + +L   + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P CK
Sbjct: 826 QCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCK 885

Query: 87  IQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEK 146
           +Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+ 
Sbjct: 886 LQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQN 945

Query: 147 LQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
           L L     +  +   L ++   KP   ELTV
Sbjct: 946 LGLSEMYFNYETKSALETLQEEKP---ELTV 973


>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
          Length = 994

 Score =  184 bits (468), Expect = 1e-46
 Identities = 116/355 (32%), Positives = 183/355 (51%), Gaps = 2/355 (0%)

Query: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
           + S L T   L+EL + D+ L ++     C  L  P CRL+KL +   S S  S   L  
Sbjct: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFE 688

Query: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
           VL  +PD K L+ +   ++   +R LC  L      ++ L L +C ++  +C  L G++ 
Sbjct: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748

Query: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
           +   L  L +  N+L D G+  LC  L  P + L  L +  C ++ + C  +  +L   +
Sbjct: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807

Query: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
           S++ L L+ N L DEG + LCE L  P C L+SL +  C  TAA C   +S L  N+ L 
Sbjct: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867

Query: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
            LQI  N + D GV+ LC+ L      L +L L +C ++ + C  LA+ L  + +L++L+
Sbjct: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927

Query: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
           L+ N L   G++ L E++R P C L+ L L    + EE +  L A E+  P+L +
Sbjct: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982



 Score =  177 bits (450), Expect = 1e-44
 Identities = 117/357 (32%), Positives = 175/357 (49%), Gaps = 2/357 (0%)

Query: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
           I S L  +  L EL ++ + L +         L+ PSC++QKL + N   +G    +L  
Sbjct: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV-LLFE 688

Query: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
            L   P L+ L  +   L    ++ LC+ L  P   +++L L  C LS   CE LA +L 
Sbjct: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748

Query: 168 AKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKA 227
                  L VS N + + GV +LC+ L      L  L L  C ++   C  +  ++    
Sbjct: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807

Query: 228 SLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLK 287
           S+R L L +N L D G+  LC  L HP   L +L + +C ITA GC DL   L + ++LK
Sbjct: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867

Query: 288 ELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
            L +  NE+GD G +LLC  L    C+LE L ++ C  T+ CC   +SVL  ++ L +L 
Sbjct: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927

Query: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
           ++ N L+  GV  LC+ L  P   L+VL L   D  + + + L A    N +L   D
Sbjct: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984



 Score =  167 bits (423), Expect = 2e-41
 Identities = 104/330 (31%), Positives = 163/330 (49%), Gaps = 16/330 (4%)

Query: 5   IQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDIS---------SALRVN 55
           ++ L +Q   LS++ +      +  C  +R   C L +    ++S           L   
Sbjct: 640 LRELQVQDSTLSESTF------VTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQ 693

Query: 56  PALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTL 115
           P L  L+    +L    +  +   L  P+  +++L+L NC L+   C VL+  L     L
Sbjct: 694 PDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKL 753

Query: 116 QELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKEL 175
             L++S N L D G+ LLCE L  P   L  L L +C LS   CE ++ +L      + L
Sbjct: 754 TYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYL 812

Query: 176 TVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALG 235
            +S N + + G++ LC+ LK   C L++L L  C +T+  C DL   + S  +L+ L +G
Sbjct: 813 DLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIG 872

Query: 236 SNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE 295
            N++GDVG+  LC  L H   RL  L + ECG+T+  C DL  VL   ++L++L+L  N 
Sbjct: 873 CNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNT 932

Query: 296 LGDEGARLLCETLLEPGCQLESLWVKSCSF 325
           L   G  +LCE L  P C L+ L ++   F
Sbjct: 933 LDHTGVVVLCEALRHPECALQVLGLRKTDF 962



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 1/116 (0%)

Query: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
           ++  C  H  SVL  +  L ELQ+ ++ L ++     C  L  P   L+ L + +   S 
Sbjct: 622 YSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSG 681

Query: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWS 440
            S   L   L     L+ L  +   L    I  L +++  P   +++L L + + S
Sbjct: 682 QSV-LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS 736


>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
          Length = 1062

 Score =  179 bits (453), Expect = 6e-45
 Identities = 119/331 (35%), Positives = 167/331 (50%), Gaps = 16/331 (4%)

Query: 4    DIQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDISSA---------LRV 54
            D+  L I    LS    A L+ +L  C+ +  D C L     K+IS A         LR 
Sbjct: 700  DLMGLAINDSFLS----ASLVRIL--CEQIASDTCHLQRVVFKNISPADAHRNLCLALRG 753

Query: 55   NPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPT 114
            +  +  L L+ N+  D+    + + L+ P C ++ L L +C  T      LS  L    +
Sbjct: 754  HKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQS 812

Query: 115  LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
            L  ++LSDN L D G +LL   L  P+C L++L LE C L+ A+C+ LA+VL    +   
Sbjct: 813  LTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTH 872

Query: 175  LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
            L ++ N I   GV+ LC+GL+   C+L+ L L +C +TSD C DL  ++  K+SL  L L
Sbjct: 873  LCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDL 932

Query: 235  GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
            G N +G  GM  LC  L  P   LR LW+W C I    C DLC  L   +SL  L L  N
Sbjct: 933  GLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN 992

Query: 295  ELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
             LG  G ++L ETL      L +L +K   F
Sbjct: 993  PLGSSGVKMLFETLTCSSGTLRTLRLKIDDF 1023



 Score =  171 bits (434), Expect = 1e-42
 Identities = 108/338 (31%), Positives = 163/338 (48%), Gaps = 2/338 (0%)

Query: 47   DISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLS 106
            D+ S    N  L  L +  + L    V  + + + + +C +Q++  +N     A    L 
Sbjct: 690  DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRN-LC 748

Query: 107  STLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVL 166
              LR   T+  L L  N   D     LCE L  P+C L  L L  CS +      L+  L
Sbjct: 749  LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807

Query: 167  RAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASK 226
                    + +S+N++ + G ++L   L+   C L+ L LE+C +T  NC+DL  ++   
Sbjct: 808  EVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVS 867

Query: 227  ASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESL 286
              L  L L  N +G+ G+  LC GL +P  +L+TL +W C IT+ GC DL ++L+ K SL
Sbjct: 868  RELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSL 927

Query: 287  KELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLEL 346
              L L  N +G +G + LCE L +P C L  LW+  CS     C    S L+ N+ L+ L
Sbjct: 928  LCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTL 987

Query: 347  QISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
             +  N L  +GV+ L + L      LR L L   D +D
Sbjct: 988  DLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFND 1025



 Score =  161 bits (408), Expect = 1e-39
 Identities = 108/343 (31%), Positives = 164/343 (47%), Gaps = 2/343 (0%)

Query: 115  LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
            L  L ++D+ L  + +++LCE +    C L+++  +  S + A    L   LR       
Sbjct: 701  LMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAH-RNLCLALRGHKTVTY 759

Query: 175  LTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELAL 234
            LT+  ND ++     LC+ L+   C L  L L SC  T+    DL   +    SL  + L
Sbjct: 760  LTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNL 818

Query: 235  GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
              N+L D G   L   L HP   L+ L +  C +T   C DL  VL     L  L LA N
Sbjct: 819  SDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKN 878

Query: 295  ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLE 354
             +G+ G + LCE L  P C+L++L + +C  T+  C   + +L +   LL L +  N + 
Sbjct: 879  PIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIG 938

Query: 355  DAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAG 414
              G++ LC+ L +P   LR LWL  C +   SC  L + L  N SL  LDL  N LG +G
Sbjct: 939  VKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSG 998

Query: 415  ILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSL 457
            +  L E++      L  L L    +++E+   L+ +E+  P L
Sbjct: 999  VKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
            sapiens]
          Length = 1043

 Score =  175 bits (443), Expect = 9e-44
 Identities = 112/321 (34%), Positives = 164/321 (51%), Gaps = 9/321 (2%)

Query: 48   ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
            I S L  N  L EL+L +++L    V  +   L+ P CK+QKL+    C +     VL  
Sbjct: 718  ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLT----CKSVTPEWVLQD 773

Query: 108  TLRTLP---TLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
             +  L     L  L+ S N LG   + L+ + L    C L+ L LE C+LSAASC+ LA 
Sbjct: 774  LIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASCQDLAL 832

Query: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
             L +      L +  N + + G+++LC  L    C LE L+L  C + +  C+ L   + 
Sbjct: 833  FLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALL 892

Query: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
               SL  L L  N L D G+  LC  L  P   L++L +  C  T +GCG+L   L    
Sbjct: 893  QNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNH 952

Query: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
            ++K L L  N+L D+G +LLCE  L+P   L +L +  C+ T ACC H  SVL+ ++ L+
Sbjct: 953  NVKILDLGENDLQDDGVKLLCEA-LKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLV 1011

Query: 345  ELQISNNRLEDAGVRELCQGL 365
             L +  N L+  GV+ LC+ L
Sbjct: 1012 NLNLLGNELDTDGVKMLCKAL 1032



 Score =  169 bits (429), Expect = 4e-42
 Identities = 100/291 (34%), Positives = 159/291 (54%), Gaps = 3/291 (1%)

Query: 29   QCQVVRLDDCGLT-EARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKI 87
            +C+V +L    +T E   +D+  AL+ N  L  LN  SN+LG + V  +L+ L+  +C +
Sbjct: 754  RCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNL 812

Query: 88   QKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
            + L L+ C L+ A C  L+  L ++  +  L L  N L D G++LLC  L  P+C LE+L
Sbjct: 813  KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872

Query: 148  QLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLE 207
            +L +C L+A +C+ L+  L        L +S N + + GV+ LC+ L      L++L L 
Sbjct: 873  ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932

Query: 208  SCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECG 267
             C  T + C +L   ++   +++ L LG N L D G+  LC  L  P   L TL + +C 
Sbjct: 933  GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCN 991

Query: 268  ITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESL 318
            +T   C  L  VL + +SL  L+L GNEL  +G ++LC+ L +  C+L+ L
Sbjct: 992  LTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKL 1042



 Score =  150 bits (378), Expect = 3e-36
 Identities = 91/263 (34%), Positives = 137/263 (52%), Gaps = 4/263 (1%)

Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD-NCRDLC 220
           + S L    +  EL +SN+ ++ + V+ LC  LK+  C+++ L  +S  VT +   +DL 
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKS--VTPEWVLQDLI 775

Query: 221 GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
             +   + L  L   SNKLG + +  +   L H +  L+ L + +C ++A  C DL   L
Sbjct: 776 IALQGNSKLTHLNFSSNKLG-MTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFL 834

Query: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
            + + +  L L  N L D+G +LLC  L  P C LE L +  C   A  C H S  L QN
Sbjct: 835 TSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQN 894

Query: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
           R L  L +S N L D GV+ LC+ LG+P   L+ L L+ C  +   C  LA  L  NH++
Sbjct: 895 RSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNV 954

Query: 401 RELDLSNNCLGDAGILQLVESVR 423
           + LDL  N L D G+  L E+++
Sbjct: 955 KILDLGENDLQDDGVKLLCEALK 977



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 66/232 (28%), Positives = 109/232 (46%), Gaps = 18/232 (7%)

Query: 219 LCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTL--------WIWECGITA 270
           +C  + +  +L EL L ++KL    +  LC  L +P  +++ L        W+ +     
Sbjct: 718 ICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPEWVLQ----- 772

Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
               DL   L+    L  L+ + N+LG     L+ + L    C L+ L ++ C+ +AA C
Sbjct: 773 ----DLIIALQGNSKLTHLNFSSNKLGMT-VPLILKALRHSACNLKYLCLEKCNLSAASC 827

Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
              +  L   + +  L +  NRL+D G++ LC  L  P   L  L L  C ++  +C  L
Sbjct: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887

Query: 391 AATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEE 442
           +  LL N SL  L+LS N L D G+  L E++ +P   L+ L L    ++ E
Sbjct: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTRE 939



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 22/80 (27%), Positives = 44/80 (55%)

Query: 372 LRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQ 431
           L +L  +  D    + +S+ +TL+ N +L ELDLSN+ L  + +  L  +++ P C +++
Sbjct: 700 LEILETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQK 759

Query: 432 LVLYDIYWSEEMEDRLQALE 451
           L    +     ++D + AL+
Sbjct: 760 LTCKSVTPEWVLQDLIIALQ 779


>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
          Length = 1048

 Score =  161 bits (408), Expect = 1e-39
 Identities = 105/317 (33%), Positives = 155/317 (48%), Gaps = 7/317 (2%)

Query: 105  LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
            L S   T   L+ L +++++LG   L+ L   L  PQC+L+KL L   + +  + + L  
Sbjct: 695  LCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDLIG 753

Query: 165  VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
            VL      + L + + ++    V++LC+ L+   C+L+ L+LE C  T     DL   + 
Sbjct: 754  VLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQ 813

Query: 225  SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
                L+ L L  N L      E C       ++L  L I  C +T   C  L   LR  +
Sbjct: 814  GNGHLKTLILRKNSL------ENCGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSK 867

Query: 285  SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
             L  LSLA N L DEGA+ +   L    C L+ L ++ C  T  CC    S L +N+ L 
Sbjct: 868  MLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLK 927

Query: 345  ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
             L +S N L+D GV  LC+ L  P   L++L L +C  +   C ++A+ L  N  LR LD
Sbjct: 928  SLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLD 987

Query: 405  LSNNCLGDAGILQLVES 421
            LS N +G  GIL L E+
Sbjct: 988  LSKNAIGVYGILTLCEA 1004



 Score =  149 bits (375), Expect = 7e-36
 Identities = 98/321 (30%), Positives = 151/321 (47%), Gaps = 13/321 (4%)

Query: 46   KDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQ---NCCLTGAGC 102
            +D+ S    N  L  L + ++ LG   +  +   L+ P CK+QKL L+   +  L     
Sbjct: 693  QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752

Query: 103  GVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPL 162
            GVL+        L+ L +    +    ++LLC  L  P+CRL+ L+LE C  +      L
Sbjct: 753  GVLTGNQH----LRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDL 808

Query: 163  ASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGI 222
             + L+     K L +  N +   G   L      S  QLE L +E+C +T   C  L   
Sbjct: 809  GNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERLSIENCNLTQLTCESLASC 862

Query: 223  VASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRA 282
            +     L  L+L  N L D G   +   L H    L+ L + +C +T   C D+   L  
Sbjct: 863  LRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCK 922

Query: 283  KESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF 342
             ++LK L L+ N L D+G  LLCE L  P C L+ L +++C FT+ CC   +S+L +N+ 
Sbjct: 923  NKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQH 982

Query: 343  LLELQISNNRLEDAGVRELCQ 363
            L  L +S N +   G+  LC+
Sbjct: 983  LRHLDLSKNAIGVYGILTLCE 1003



 Score =  118 bits (295), Expect = 1e-26
 Identities = 82/275 (29%), Positives = 132/275 (48%), Gaps = 7/275 (2%)

Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
           + L SV       + LT++N+ +    ++ L   L+   C+L+ L L     T  N +DL
Sbjct: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLN-QDL 751

Query: 220 CGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRV 279
            G++     LR L +   ++    +  LC  L  P  RL+ L + +C  T +   DL   
Sbjct: 752 IGVLTGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNN 811

Query: 280 LRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQ 339
           L+    LK L L  N L + GA  L         QLE L +++C+ T   C   +S L Q
Sbjct: 812 LQGNGHLKTLILRKNSLENCGAYYLSVA------QLERLSIENCNLTQLTCESLASCLRQ 865

Query: 340 NRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHS 399
           ++ L  L ++ N L+D G + +   L      L+ L L  CD++ + C  + + L  N +
Sbjct: 866 SKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKT 925

Query: 400 LRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
           L+ LDLS N L D G++ L E+++ P C L+ L L
Sbjct: 926 LKSLDLSFNSLKDDGVILLCEALKNPDCTLQILEL 960



 Score =  118 bits (295), Expect = 1e-26
 Identities = 72/218 (33%), Positives = 112/218 (51%), Gaps = 6/218 (2%)

Query: 31   QVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKL 90
            Q +RL+DC  T     D+ + L+ N  L  L LR N L + G + +         ++++L
Sbjct: 791  QCLRLEDCLATPRIWTDLGNNLQGNGHLKTLILRKNSLENCGAYYL------SVAQLERL 844

Query: 91   SLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLE 150
            S++NC LT   C  L+S LR    L  L L++N L D G + +   L   +C L++L L 
Sbjct: 845  SIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQRLVLR 904

Query: 151  YCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCG 210
             C L+   C+ + S L      K L +S N + + GV +LC+ LK+  C L+ L+LE+C 
Sbjct: 905  KCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILELENCL 964

Query: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELC 248
             TS  C+ +  ++     LR L L  N +G  G+  LC
Sbjct: 965  FTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLC 1002



 Score =  107 bits (266), Expect = 3e-23
 Identities = 60/176 (34%), Positives = 92/176 (52%)

Query: 29   QCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQ 88
            Q + + +++C LT+  C+ ++S LR +  L  L+L  N L D G   +   L    C +Q
Sbjct: 840  QLERLSIENCNLTQLTCESLASCLRQSKMLTHLSLAENALKDEGAKHIWNALPHLRCPLQ 899

Query: 89   KLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQ 148
            +L L+ C LT   C  + S L    TL+ L LS N L D G+ LLCE L +P C L+ L+
Sbjct: 900  RLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEALKNPDCTLQILE 959

Query: 149  LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEAL 204
            LE C  ++  C+ +AS+LR     + L +S N I   G+  LC+       + E +
Sbjct: 960  LENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSSQKKREEVI 1015



 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 47/126 (37%), Positives = 62/126 (49%)

Query: 20   WAELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQG 79
            W  L  L    Q + L  C LT   C+D+ SAL  N  L  L+L  N L D GV  + + 
Sbjct: 888  WNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDLSFNSLKDDGVILLCEA 947

Query: 80   LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
            L+ P C +Q L L+NC  T   C  ++S LR    L+ L LS N +G  G+  LCE    
Sbjct: 948  LKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKNAIGVYGILTLCEAFSS 1007

Query: 140  PQCRLE 145
             + R E
Sbjct: 1008 QKKREE 1013



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 1/102 (0%)

Query: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
           SV A N  L  L ++N+ L    ++ L   L  P   L+ L L   + S      L   L
Sbjct: 697 SVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVN-STMLNQDLIGVL 755

Query: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
             N  LR L++ +  +    +  L   +R P C L+ L L D
Sbjct: 756 TGNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLED 797


>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
           sapiens]
          Length = 922

 Score =  154 bits (388), Expect = 2e-37
 Identities = 78/195 (40%), Positives = 119/195 (61%)

Query: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
           CG++ + C D+  VL + + L EL L+ N LGD G RLLC  L    C L+ LW+ +   
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782

Query: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDS 385
           T+ CCS  SSVL+ N+ L  L +  N L D G++ LC+GL  P   L+VL L +C+++  
Sbjct: 783 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842

Query: 386 SCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMED 445
            C  L+  L ++ SLR+L L NN LGD G++   E ++Q  CLL+ L L ++Y++ E + 
Sbjct: 843 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 902

Query: 446 RLQALEKDKPSLRVI 460
            L+ L+++KP L V+
Sbjct: 903 ALETLQEEKPELTVV 917



 Score =  138 bits (348), Expect = 9e-33
 Identities = 72/172 (41%), Positives = 102/172 (59%)

Query: 35  LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
           L  CGL+   C DIS  L  N  L EL+L  N LGD G+  +  GL+   C ++KL L N
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779

Query: 95  CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
             LT   C  LSS L T   L  L+L  N LGD G++LLCEGLL P C+L+ L+L+ C+L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839

Query: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKL 206
           ++  C  L+++L +    ++L++ NND+ + GV + C+ LK   C L+ L L
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGL 891



 Score =  129 bits (324), Expect = 6e-30
 Identities = 68/174 (39%), Positives = 101/174 (58%)

Query: 206 LESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWE 265
           L  CG++ + C D+  +++S   L EL L  N LGD G+  LC GL H    L+ LW+  
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779

Query: 266 CGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
            G+T+  C  L  VL   ++L  L L GN LGD+G +LLCE LL P C+L+ L + +C+ 
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839

Query: 326 TAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLAD 379
           T+ CC   S++L  ++ L +L + NN L D GV   C+ L Q   +L+ L L++
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 893



 Score =  126 bits (317), Expect = 4e-29
 Identities = 66/174 (37%), Positives = 100/174 (57%)

Query: 152 CSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGV 211
           C LS   C  ++ VL +     EL +S+N + + G+R+LC GLK   C L+ L L + G+
Sbjct: 723 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 782

Query: 212 TSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAK 271
           TS  C  L  ++++  +L  L L  N LGD G+  LC GLLHP  +L+ L +  C +T+ 
Sbjct: 783 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 842

Query: 272 GCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSF 325
            C DL  +L + +SL++LSL  N+LGD G  + CE L +  C L++L +    F
Sbjct: 843 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYF 896



 Score =  126 bits (316), Expect = 5e-29
 Identities = 73/193 (37%), Positives = 106/193 (54%), Gaps = 3/193 (1%)

Query: 73  VHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQL 132
           V CVL      +C      L  C L+   C  +S  L +   L EL LSDN LGD G++L
Sbjct: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760

Query: 133 LCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQ 192
           LC GL    C L+KL L    L++  C  L+SVL    +   L +  N + + G+++LC+
Sbjct: 761 LCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCE 820

Query: 193 GLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLL 252
           GL    C+L+ L+L++C +TS  C DL  ++ S  SLR+L+LG+N LGD+G+   C  L 
Sbjct: 821 GLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLK 880

Query: 253 HPSSRLRTLWIWE 265
             S  L+ L + E
Sbjct: 881 QQSCLLQNLGLSE 893



 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 58/152 (38%), Positives = 79/152 (51%), Gaps = 3/152 (1%)

Query: 26  LLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSC 85
           LL   + + L + GLT   C  +SS L  N  L  L LR N LGD G+  + +GL  P C
Sbjct: 768 LLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 827

Query: 86  KIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLE 145
           K+Q L L NC LT   C  LS+ L +  +L++L L +N LGD G+ + CE L    C L+
Sbjct: 828 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 887

Query: 146 KLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177
            L L     +  +   L ++   KP   ELTV
Sbjct: 888 NLGLSEMYFNYETKSALETLQEEKP---ELTV 916



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 23/58 (39%), Positives = 32/58 (55%)

Query: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
           L  C +S   C  ++  L +N  L ELDLS+N LGD GI  L   ++   C L++L L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWL 777


>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
            3 [Homo sapiens]
          Length = 1037

 Score =  145 bits (366), Expect = 8e-35
 Identities = 102/359 (28%), Positives = 173/359 (48%), Gaps = 7/359 (1%)

Query: 102  CGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEP 161
            C + SS       L+ L +  + L D+ +++LC+ +    C L+K++++  +   A  + 
Sbjct: 668  CSLFSSN----SNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDF 723

Query: 162  LASVLRAKPDFKELTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLC 220
              + +  K     LT++ + +     + +LC  L++  C L+ L+L     T +   +  
Sbjct: 724  CLAFI-GKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFF 782

Query: 221  GIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVL 280
             ++ +  SL+ L L +N L D G   L   +  P   L+ L +  C +T   C DL  VL
Sbjct: 783  YVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVL 842

Query: 281  RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
               + L  L LA N +GD G + LCE L  P C+L++L ++ CS T   C + S  L + 
Sbjct: 843  VVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEA 902

Query: 341  RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
              L  L +S N++   G+  LCQ L  P   L+ L L  C +    C  L + LL+N  L
Sbjct: 903  CSLTNLDLSINQIA-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKL 961

Query: 401  RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
              LDL  N L  +GI++L   +RQ    L+ L L     + E++  L+ +++  P L +
Sbjct: 962  ETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 1020



 Score =  119 bits (299), Expect = 4e-27
 Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)

Query: 26  LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
           +L  C ++R   C L          T  +  +    L+ N +L  L L +N L D G   
Sbjct: 749 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 808

Query: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
           + + +  P   +Q LSL+NC LT A C  L++ L     L  L L+ N +GD G++ LCE
Sbjct: 809 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868

Query: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
           GL  P C+L+ L L+ CS++   C  L+  L+       L +S N I   G+ +LCQ L+
Sbjct: 869 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 927

Query: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
           +  C L+ L+L SC +    C+ L   + S   L  L LG N L   G+ +L   L   +
Sbjct: 928 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 987

Query: 256 SRLRTL 261
             L+ L
Sbjct: 988 GSLKIL 993



 Score =  118 bits (296), Expect = 1e-26
 Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)

Query: 80  LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
           L+   C +Q L L   C T          L+   +L+ L LS N+L D G  LL + +  
Sbjct: 756 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 815

Query: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
           P+  L+ L LE C L+ ASC+ LA+VL        L ++ N I + GV+ LC+GL    C
Sbjct: 816 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 875

Query: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
           +L+ L L+ C +T   CR L   +    SL  L L  N++   G+  LC  L +P+  L+
Sbjct: 876 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 934

Query: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
            L +W C +    C  L   L + + L+ L L  N L   G   L   L +    L+ L 
Sbjct: 935 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 994

Query: 320 VKS 322
           +K+
Sbjct: 995 LKT 997



 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 74/275 (26%), Positives = 116/275 (42%), Gaps = 58/275 (21%)

Query: 218 DLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI-------------- 263
           D C + +S ++L+ L +  + L D  +  LC  +   +  L+ + I              
Sbjct: 666 DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCL 725

Query: 264 ------------------WE---------------CGITAKGCGDLCR----------VL 280
                             WE               C +     G  C           VL
Sbjct: 726 AFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVL 785

Query: 281 RAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQN 340
           +A +SLK L L+ N L DEGA LL +T+  P   L+ L +++C  T A C   ++VL  +
Sbjct: 786 KANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVS 845

Query: 341 RFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
           + L  L ++ N + D GV+ LC+GL  P   L+ L L  C ++   C  L+  L    SL
Sbjct: 846 KKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSL 905

Query: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLY 435
             LDLS N +   G+  L +++  P C L+ L L+
Sbjct: 906 TNLDLSINQIA-RGLWILCQALENPNCNLKHLRLW 939



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 45/178 (25%), Positives = 75/178 (42%), Gaps = 11/178 (6%)

Query: 258 LRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLES 317
           LR+L +W          D C +  +  +LK L +  + L D   R+LC+ +    C L+ 
Sbjct: 658 LRSLRLWT---------DFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQK 708

Query: 318 LWVKSCSFTAACCSHFSSVLAQNRFLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLW 376
           + +K+ +   A    F       + L  L ++ +   E   +  LC  L      L+ L 
Sbjct: 709 VEIKNVTPDTA-YRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLR 767

Query: 377 LADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
           L     +    +     L AN SL+ L LS N L D G + L +++ +P   L+ L L
Sbjct: 768 LGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 825


>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
           1 [Homo sapiens]
          Length = 1009

 Score =  144 bits (364), Expect = 1e-34
 Identities = 99/346 (28%), Positives = 169/346 (48%), Gaps = 3/346 (0%)

Query: 115 LQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKE 174
           L+ L +  + L D+ +++LC+ +    C L+K++++  +   A  +   + +  K     
Sbjct: 649 LKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLTH 707

Query: 175 LTVSNN-DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELA 233
           LT++ + +     + +LC  L++  C L+ L+L     T +   +   ++ +  SL+ L 
Sbjct: 708 LTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLR 767

Query: 234 LGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAG 293
           L +N L D G   L   +  P   L+ L +  C +T   C DL  VL   + L  L LA 
Sbjct: 768 LSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAK 827

Query: 294 NELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRL 353
           N +GD G + LCE L  P C+L++L ++ CS T   C + S  L +   L  L +S N++
Sbjct: 828 NPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI 887

Query: 354 EDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDA 413
              G+  LCQ L  P   L+ L L  C +    C  L + LL+N  L  LDL  N L  +
Sbjct: 888 A-RGLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKS 946

Query: 414 GILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
           GI++L   +RQ    L+ L L     + E++  L+ +++  P L +
Sbjct: 947 GIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKNPKLTI 992



 Score =  121 bits (303), Expect = 2e-27
 Identities = 88/267 (32%), Positives = 134/267 (50%), Gaps = 5/267 (1%)

Query: 171 DFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC-RDLCGIVASKASL 229
           + K L V  + ++++ VR+LC  +  S C L+  K+E   VT D   RD C     K +L
Sbjct: 648 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQ--KVEIKNVTPDTAYRDFCLAFIGKKTL 705

Query: 230 RELAL-GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKE 288
             L L G  +     M  LC  L +    L+ L +     T +   +   VL+A +SLK 
Sbjct: 706 THLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKH 765

Query: 289 LSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQI 348
           L L+ N L DEGA LL +T+  P   L+ L +++C  T A C   ++VL  ++ L  L +
Sbjct: 766 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 825

Query: 349 SNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNN 408
           + N + D GV+ LC+GL  P   L+ L L  C ++   C  L+  L    SL  LDLS N
Sbjct: 826 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 885

Query: 409 CLGDAGILQLVESVRQPGCLLEQLVLY 435
            +   G+  L +++  P C L+ L L+
Sbjct: 886 QIA-RGLWILCQALENPNCNLKHLRLW 911



 Score =  119 bits (299), Expect = 4e-27
 Identities = 79/246 (32%), Positives = 119/246 (48%), Gaps = 11/246 (4%)

Query: 26  LLQQCQVVRLDDCGL----------TEARCKDISSALRVNPALAELNLRSNELGDVGVHC 75
           +L  C ++R   C L          T  +  +    L+ N +L  L L +N L D G   
Sbjct: 721 MLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAML 780

Query: 76  VLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCE 135
           + + +  P   +Q LSL+NC LT A C  L++ L     L  L L+ N +GD G++ LCE
Sbjct: 781 LYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 840

Query: 136 GLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLK 195
           GL  P C+L+ L L+ CS++   C  L+  L+       L +S N I   G+ +LCQ L+
Sbjct: 841 GLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQI-ARGLWILCQALE 899

Query: 196 DSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPS 255
           +  C L+ L+L SC +    C+ L   + S   L  L LG N L   G+ +L   L   +
Sbjct: 900 NPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRT 959

Query: 256 SRLRTL 261
             L+ L
Sbjct: 960 GSLKIL 965



 Score =  118 bits (296), Expect = 1e-26
 Identities = 78/243 (32%), Positives = 116/243 (47%), Gaps = 1/243 (0%)

Query: 80  LQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLD 139
           L+   C +Q L L   C T          L+   +L+ L LS N+L D G  LL + +  
Sbjct: 728 LRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTR 787

Query: 140 PQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPC 199
           P+  L+ L LE C L+ ASC+ LA+VL        L ++ N I + GV+ LC+GL    C
Sbjct: 788 PKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDC 847

Query: 200 QLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
           +L+ L L+ C +T   CR L   +    SL  L L  N++   G+  LC  L +P+  L+
Sbjct: 848 KLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLK 906

Query: 260 TLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLW 319
            L +W C +    C  L   L + + L+ L L  N L   G   L   L +    L+ L 
Sbjct: 907 HLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILR 966

Query: 320 VKS 322
           +K+
Sbjct: 967 LKT 969



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 39/154 (25%), Positives = 66/154 (42%), Gaps = 2/154 (1%)

Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNR 341
           +  +LK L +  + L D   R+LC+ +    C L+ + +K+ +   A    F       +
Sbjct: 645 SNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTA-YRDFCLAFIGKK 703

Query: 342 FLLELQISNN-RLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSL 400
            L  L ++ +   E   +  LC  L      L+ L L     +    +     L AN SL
Sbjct: 704 TLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFYVLKANQSL 763

Query: 401 RELDLSNNCLGDAGILQLVESVRQPGCLLEQLVL 434
           + L LS N L D G + L +++ +P   L+ L L
Sbjct: 764 KHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797


>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
           sapiens]
          Length = 1429

 Score =  141 bits (355), Expect = 1e-33
 Identities = 79/186 (42%), Positives = 104/186 (55%)

Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
           A+ SL+ELDL  N L D G+  L E +R P C L +L L     S+EM   L+ALE++KP
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979

Query: 456 SLRVIS 461
            L + S
Sbjct: 980 QLLIFS 985



 Score =  130 bits (328), Expect = 2e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  129 bits (325), Expect = 4e-30
 Identities = 72/190 (37%), Positives = 109/190 (57%)

Query: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L L+   ++ +  ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 220 CGIVASKASL 229
             +   K  L
Sbjct: 972 RALEQEKPQL 981



 Score =  126 bits (316), Expect = 5e-29
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  122 bits (305), Expect = 9e-28
 Identities = 71/182 (39%), Positives = 97/182 (53%)

Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
           VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
           + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
              +SVL+ +  L EL +  N L+D GVR LC+GL  P   L  L L    +SD     L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 391 AA 392
            A
Sbjct: 972 RA 973



 Score =  115 bits (289), Expect = 6e-26
 Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)

Query: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868

Query: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928

Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
           L  N L D G++LLCEGL  P C+L +L L+  +LS    + L ++ + KP
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837

Query: 428 LLEQLVL 434
           LLE L L
Sbjct: 838 LLETLRL 844


>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
           sapiens]
          Length = 1375

 Score =  141 bits (355), Expect = 1e-33
 Identities = 79/186 (42%), Positives = 104/186 (55%)

Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
           A+ SL+ELDL  N L D G+  L E +R P C L +L L     S+EM   L+ALE++KP
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979

Query: 456 SLRVIS 461
            L + S
Sbjct: 980 QLLIFS 985



 Score =  130 bits (328), Expect = 2e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  129 bits (325), Expect = 4e-30
 Identities = 72/190 (37%), Positives = 109/190 (57%)

Query: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L L+   ++ +  ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 220 CGIVASKASL 229
             +   K  L
Sbjct: 972 RALEQEKPQL 981



 Score =  126 bits (316), Expect = 5e-29
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  122 bits (305), Expect = 9e-28
 Identities = 71/182 (39%), Positives = 97/182 (53%)

Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
           VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
           + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
              +SVL+ +  L EL +  N L+D GVR LC+GL  P   L  L L    +SD     L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 391 AA 392
            A
Sbjct: 972 RA 973



 Score =  115 bits (289), Expect = 6e-26
 Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)

Query: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868

Query: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928

Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
           L  N L D G++LLCEGL  P C+L +L L+  +LS    + L ++ + KP
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837

Query: 428 LLEQLVL 434
           LLE L L
Sbjct: 838 LLETLRL 844


>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
           sapiens]
          Length = 1473

 Score =  141 bits (355), Expect = 1e-33
 Identities = 79/186 (42%), Positives = 104/186 (55%)

Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKP 455
           A+ SL+ELDL  N L D G+  L E +R P C L +L L     S+EM   L+ALE++KP
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979

Query: 456 SLRVIS 461
            L + S
Sbjct: 980 QLLIFS 985



 Score =  130 bits (328), Expect = 2e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  129 bits (325), Expect = 4e-30
 Identities = 72/190 (37%), Positives = 109/190 (57%)

Query: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L L+   ++ +  ++L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 220 CGIVASKASL 229
             +   K  L
Sbjct: 972 RALEQEKPQL 981



 Score =  126 bits (316), Expect = 5e-29
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  122 bits (305), Expect = 9e-28
 Identities = 71/182 (39%), Positives = 97/182 (53%)

Query: 211 VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
           VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 271 KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
           + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 331 SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSL 390
              +SVL+ +  L EL +  N L+D GVR LC+GL  P   L  L L    +SD     L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQEL 971

Query: 391 AA 392
            A
Sbjct: 972 RA 973



 Score =  115 bits (289), Expect = 6e-26
 Identities = 67/171 (39%), Positives = 97/171 (56%), Gaps = 4/171 (2%)

Query: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868

Query: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928

Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKP 170
           L  N L D G++LLCEGL  P C+L +L L+  +LS    + L ++ + KP
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQEKP 979



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837

Query: 428 LLEQLVL 434
           LLE L L
Sbjct: 838 LLETLRL 844


>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
           sapiens]
          Length = 1399

 Score =  130 bits (328), Expect = 2e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  129 bits (323), Expect = 7e-30
 Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)

Query: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L   S  +T     D 
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970

Query: 220 CGIVASKASLRELALGSNK 238
             +  S +SL+   LGS +
Sbjct: 971 GEMSNSTSSLKRQRLGSER 989



 Score =  126 bits (316), Expect = 5e-29
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  121 bits (304), Expect = 1e-27
 Identities = 67/157 (42%), Positives = 87/157 (55%)

Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432
           A+ SL+ELDL  N L D G+  L E +R P C L +L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956



 Score =  119 bits (297), Expect = 8e-27
 Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)

Query: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
            VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
            + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 331  SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381
               +SVL+ +  L EL +  N L+D GVR LC+GL  P          SV+      D  
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971

Query: 382  VSDSSCSSL---------AATLLANHSLRELDLS 406
               +S SSL         AA+ +A  +L+ LD+S
Sbjct: 972  EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005



 Score =  108 bits (270), Expect = 1e-23
 Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)

Query: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868

Query: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928

Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
           L  N L D G++LLCEGL  P C+L +L
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 49/124 (39%), Positives = 67/124 (54%)

Query: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
           SVL   R L EL +S N L  + V+ LC+ L +P  +L  L LA C ++   C  LA  L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861

Query: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454
            AN +L ELDLS N L DAG   L + +RQP C L++L L     + +    L ++    
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921

Query: 455 PSLR 458
           PSL+
Sbjct: 922 PSLK 925



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837

Query: 428 LLEQLVL 434
           LLE L L
Sbjct: 838 LLETLRL 844


>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
           sapiens]
          Length = 1443

 Score =  130 bits (328), Expect = 2e-30
 Identities = 70/162 (43%), Positives = 100/162 (61%)

Query: 97  LTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSA 156
           +T A   +L S L+    L+EL LS N L  + ++ LC+ L  P+C LE L+L  C L+A
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 157 ASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNC 216
             C+ LA  LRA     EL +S N + +AG + LCQ L+   C+L+ L+L SCG+TSD C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 217 RDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRL 258
           +DL  ++++  SL+EL L  N L DVG+  LC GL HP+ +L
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  129 bits (323), Expect = 7e-30
 Identities = 77/199 (38%), Positives = 112/199 (56%), Gaps = 1/199 (0%)

Query: 40  LTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTG 99
           +T+A  + + S L+V   L EL+L  N L    V  + + L+ P C ++ L L  C LT 
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 100 AGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASC 159
             C  L+  LR   TL EL LS N+L DAG + LC+ L  P C+L++LQL  C L++  C
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 160 EPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDL 219
           + LASVL A P  KEL +  N++++ GVR+LC+GL+   C+L  L   S  +T     D 
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSV-MTPTEGLDT 970

Query: 220 CGIVASKASLRELALGSNK 238
             +  S +SL+   LGS +
Sbjct: 971 GEMSNSTSSLKRQRLGSER 989



 Score =  126 bits (316), Expect = 5e-29
 Identities = 67/154 (43%), Positives = 91/154 (59%)

Query: 162 LASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCG 221
           L SVL+   + KEL +S N ++ + V+ LC+ L+   C LE L+L  CG+T+++C+DL  
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 222 IVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLR 281
            + +  +L EL L  N L D G   LC  L  PS +L+ L +  CG+T+  C DL  VL 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 282 AKESLKELSLAGNELGDEGARLLCETLLEPGCQL 315
           A  SLKEL L  N L D G RLLCE L  P C+L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKL 953



 Score =  121 bits (304), Expect = 1e-27
 Identities = 67/157 (42%), Positives = 87/157 (55%)

Query: 276 LCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSS 335
           L  VL+   +LKEL L+GN L     + LC+TL  P C LE+L +  C  TA  C   + 
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859

Query: 336 VLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLL 395
            L  N+ L EL +S N L DAG + LCQ L QP   L+ L L  C ++   C  LA+ L 
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919

Query: 396 ANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQL 432
           A+ SL+ELDL  N L D G+  L E +R P C L +L
Sbjct: 920 ASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRL 956



 Score =  119 bits (297), Expect = 8e-27
 Identities = 78/214 (36%), Positives = 110/214 (51%), Gaps = 18/214 (8%)

Query: 211  VTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITA 270
            VT    + L  ++    +L+EL L  N L    +  LC  L  P   L TL +  CG+TA
Sbjct: 792  VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851

Query: 271  KGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACC 330
            + C DL   LRA ++L EL L+ N L D GA+ LC+ L +P C+L+ L + SC  T+ CC
Sbjct: 852  EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911

Query: 331  SHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPG---------SVLRVLWLADCD 381
               +SVL+ +  L EL +  N L+D GVR LC+GL  P          SV+      D  
Sbjct: 912  QDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGKPSVMTPTEGLDTG 971

Query: 382  VSDSSCSSL---------AATLLANHSLRELDLS 406
               +S SSL         AA+ +A  +L+ LD+S
Sbjct: 972  EMSNSTSSLKRQRLGSERAASHVAQANLKLLDVS 1005



 Score =  108 bits (270), Expect = 1e-23
 Identities = 61/148 (41%), Positives = 85/148 (57%), Gaps = 4/148 (2%)

Query: 4   DIQSLDIQCEELSDARWAELLPLLQQ----CQVVRLDDCGLTEARCKDISSALRVNPALA 59
           +++ LD+    LS +    L   L++     + +RL  CGLT   CKD++  LR N  L 
Sbjct: 809 NLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLT 868

Query: 60  ELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELH 119
           EL+L  N L D G   + Q L+ PSCK+Q+L L +C LT   C  L+S L   P+L+EL 
Sbjct: 869 ELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELD 928

Query: 120 LSDNLLGDAGLQLLCEGLLDPQCRLEKL 147
           L  N L D G++LLCEGL  P C+L +L
Sbjct: 929 LQQNNLDDVGVRLLCEGLRHPACKLIRL 956



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 49/124 (39%), Positives = 67/124 (54%)

Query: 335 SVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATL 394
           SVL   R L EL +S N L  + V+ LC+ L +P  +L  L LA C ++   C  LA  L
Sbjct: 802 SVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGL 861

Query: 395 LANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDK 454
            AN +L ELDLS N L DAG   L + +RQP C L++L L     + +    L ++    
Sbjct: 862 RANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLSAS 921

Query: 455 PSLR 458
           PSL+
Sbjct: 922 PSLK 925



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 24/67 (35%), Positives = 37/67 (55%), Gaps = 3/67 (4%)

Query: 368 PGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGC 427
           P  V+   W+    V+D+    L + L    +L+ELDLS N L  + +  L +++R+P C
Sbjct: 781 PTMVVLFRWVP---VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRC 837

Query: 428 LLEQLVL 434
           LLE L L
Sbjct: 838 LLETLRL 844


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,632,089
Number of Sequences: 37866
Number of extensions: 751481
Number of successful extensions: 2857
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 62
Number of HSP's successfully gapped in prelim test: 63
Number of HSP's that attempted gapping in prelim test: 2008
Number of HSP's gapped (non-prelim): 452
length of query: 461
length of database: 18,247,518
effective HSP length: 106
effective length of query: 355
effective length of database: 14,233,722
effective search space: 5052971310
effective search space used: 5052971310
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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