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Search of human proteins with 126507087
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
(472 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126507087 bone morphogenetic protein 3 preproprotein [Homo sa... 966 0.0
gi|4826740 growth differentiation factor 10 precursor [Homo sapi... 342 4e-94
gi|4502425 bone morphogenetic protein 6 preproprotein [Homo sapi... 120 3e-27
gi|157276597 bone morphogenetic protein 4 preproprotein [Homo sa... 119 5e-27
gi|157276595 bone morphogenetic protein 4 preproprotein [Homo sa... 119 5e-27
gi|157276593 bone morphogenetic protein 4 preproprotein [Homo sa... 119 5e-27
gi|4557369 bone morphogenetic protein 2 preproprotein [Homo sapi... 119 8e-27
gi|10835091 bone morphogenetic protein 5 preproprotein [Homo sap... 117 2e-26
gi|4503969 growth differentiation factor 5 preproprotein [Homo s... 115 1e-25
gi|48475062 growth differentiation factor 6 precursor [Homo sapi... 115 1e-25
gi|29571106 bone morphogenetic protein 8B preproprotein [Homo sa... 114 2e-25
gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens] 113 3e-25
gi|61835232 growth differentiation factor 7 preproprotein [Homo ... 113 3e-25
gi|145611428 bone morphogenetic protein 8A [Homo sapiens] 113 4e-25
gi|10190670 growth differentiation factor 3 precursor [Homo sapi... 103 3e-22
gi|110349792 growth differentiation factor 1 [Homo sapiens] 97 3e-20
gi|7705308 growth differentiation factor 2 [Homo sapiens] 94 3e-19
gi|7656928 bone morphogenetic protein 10 preproprotein [Homo sap... 91 3e-18
gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens] 89 1e-17
gi|222352098 nodal precursor [Homo sapiens] 86 6e-17
gi|4504699 inhibin beta A precursor [Homo sapiens] 84 3e-16
gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens] 84 3e-16
gi|4885261 growth differentiation factor 9 precursor [Homo sapiens] 82 1e-15
gi|13899338 activin beta E [Homo sapiens] 81 2e-15
gi|5031613 growth differentiation factor 11 precursor [Homo sapi... 78 2e-14
gi|4885259 myostatin [Homo sapiens] 76 6e-14
gi|5031795 inhibin beta C chain preproprotein [Homo sapiens] 75 2e-13
gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo ... 66 6e-11
gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo sa... 64 3e-10
gi|4504697 inhibin alpha subunit precursor [Homo sapiens] 61 3e-09
>gi|126507087 bone morphogenetic protein 3 preproprotein [Homo
sapiens]
Length = 472
Score = 966 bits (2496), Expect = 0.0
Identities = 472/472 (100%), Positives = 472/472 (100%)
Query: 1 MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHM 60
MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHM
Sbjct: 1 MAGASRLLFLWLGCFCVSLAQGERPKPPFPELRKAVPGDRTAGGGPDSELQPQDKVSEHM 60
Query: 61 LRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTS 120
LRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTS
Sbjct: 61 LRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSFRAAAAETLERKGLYIFNLTS 120
Query: 121 LTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLL 180
LTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLL
Sbjct: 121 LTKSENILSATLYFCIGELGNISLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLL 180
Query: 181 GHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYI 240
GHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYI
Sbjct: 181 GHLSVDMAKSHRDIMSWLSKDITQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFPEPYI 240
Query: 241 LVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNN 300
LVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNN
Sbjct: 241 LVYANDAAISEPESVVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNN 300
Query: 301 ELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKAR 360
ELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKAR
Sbjct: 301 ELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKAR 360
Query: 361 RKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ 420
RKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ
Sbjct: 361 RKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQ 420
Query: 421 SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR
Sbjct: 421 SIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
>gi|4826740 growth differentiation factor 10 precursor [Homo
sapiens]
Length = 478
Score = 342 bits (877), Expect = 4e-94
Identities = 215/461 (46%), Positives = 279/461 (60%), Gaps = 67/461 (14%)
Query: 37 PGDRTAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNT 96
PGD A GP + QD V+ HM RLY++YS Q AR G GNT
Sbjct: 60 PGDAAATLGPSA----QDMVAVHMHRLYEKYSR-QGARPGG----------------GNT 98
Query: 97 VRSFRAAAAETLERKGLYIFNLTSLTKSENILSATLYF--------------CIGELGNI 142
VRSFRA E +++K +Y FNLTS+ SE IL+AT +F C N
Sbjct: 99 VRSFRARL-EVVDQKAVYFFNLTSMQDSEMILTATFHFYSEPPRWPRALEVLCKPRAKNA 157
Query: 143 SLSCPVSGGCSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHLSVDMAKSHRDIMSWLSKDI 202
S P+ G R+H+ L + + Q L G ++ +A R + W +KDI
Sbjct: 158 S-GRPLPLG---PPTRQHL---LFRSLSQNTATQGLLRGAMA--LAPPPRGL--WQAKDI 206
Query: 203 TQLLRKAKENEEFLIGFNITSKGRQLPKRRLPFP-EPYILVYANDAAISEPESVVSSLQG 261
+ +++ A+ + E L+ + S+ R P P P PYILVYAND AISEP SV +LQ
Sbjct: 207 SPIVKAARRDGELLLSAQLDSEERD-PGVPRPSPYAPYILVYANDLAISEPNSVAVTLQR 265
Query: 262 HRNFPTGTVPKWDSHIRAAL--SIERRKKRSTGVLLPLQNNELPGAEYQ--------YKK 311
+ FP G D RAA S + R +R+ PLQ+NELPG + + + K
Sbjct: 266 YDPFPAG-----DPEPRAAPNNSADPRVRRAAQATGPLQDNELPGLDERPPRAHAQHFHK 320
Query: 312 DEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCA 371
++W P++ L+ + K + KK Q SQ L FDE+T++KARRKQW EPR C+
Sbjct: 321 HQLWPS--PFRALKPRPGRKDRRKKGQEVFM-AASQVLDFDEKTMQKARRKQWDEPRVCS 377
Query: 372 RRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPG 431
RRYLKVDFADIGW+EWIISPKSFDAYYC+GAC+FPMPK ++PSNHATIQSIVRAVG++PG
Sbjct: 378 RRYLKVDFADIGWNEWIISPKSFDAYYCAGACEFPMPKIVRPSNHATIQSIVRAVGIIPG 437
Query: 432 IPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
IPEPCCVP+KM+SL +LF DEN+NVVLKVYPNM+V++CACR
Sbjct: 438 IPEPCCVPDKMNSLGVLFLDENRNVVLKVYPNMSVDTCACR 478
>gi|4502425 bone morphogenetic protein 6 preproprotein [Homo
sapiens]
Length = 513
Score = 120 bits (300), Expect = 3e-27
Identities = 53/150 (35%), Positives = 87/150 (58%), Gaps = 11/150 (7%)
Query: 322 KTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFAD 381
++ ++ ++S+N+ Q + R S ++ LK A C + L V F D
Sbjct: 374 RSASSRRRQQSRNRSTQSQDVARVSSASDYNSSELKTA----------CRKHELYVSFQD 423
Query: 382 IGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEK 441
+GW +WII+PK + A YC G C FP+ + +NHA +Q++V + +P+PCC P K
Sbjct: 424 LGWQDWIIAPKGYAANYCDGECSFPLNAHMNATNHAIVQTLVHLMN-PEYVPKPCCAPTK 482
Query: 442 MSSLSILFFDENKNVVLKVYPNMTVESCAC 471
++++S+L+FD+N NV+LK Y NM V +C C
Sbjct: 483 LNAISVLYFDDNSNVILKKYRNMVVRACGC 512
>gi|157276597 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 119 bits (299), Expect = 5e-27
Identities = 55/138 (39%), Positives = 84/138 (60%), Gaps = 16/138 (11%)
Query: 335 KKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSF 394
+++ ++ P SQ +AR+K +NC R L VDF+D+GW++WI++P +
Sbjct: 287 RRRAKRSPKHHSQ----------RARKKN----KNCRRHSLYVDFSDVGWNDWIVAPPGY 332
Query: 395 DAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENK 454
A+YC G C FP+ L +NHA +Q++V +V IP+ CCVP ++S++S+L+ DE
Sbjct: 333 QAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN--SSIPKACCVPTELSAISMLYLDEYD 390
Query: 455 NVVLKVYPNMTVESCACR 472
VVLK Y M VE C CR
Sbjct: 391 KVVLKNYQEMVVEGCGCR 408
>gi|157276595 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 119 bits (299), Expect = 5e-27
Identities = 55/138 (39%), Positives = 84/138 (60%), Gaps = 16/138 (11%)
Query: 335 KKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSF 394
+++ ++ P SQ +AR+K +NC R L VDF+D+GW++WI++P +
Sbjct: 287 RRRAKRSPKHHSQ----------RARKKN----KNCRRHSLYVDFSDVGWNDWIVAPPGY 332
Query: 395 DAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENK 454
A+YC G C FP+ L +NHA +Q++V +V IP+ CCVP ++S++S+L+ DE
Sbjct: 333 QAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN--SSIPKACCVPTELSAISMLYLDEYD 390
Query: 455 NVVLKVYPNMTVESCACR 472
VVLK Y M VE C CR
Sbjct: 391 KVVLKNYQEMVVEGCGCR 408
>gi|157276593 bone morphogenetic protein 4 preproprotein [Homo
sapiens]
Length = 408
Score = 119 bits (299), Expect = 5e-27
Identities = 55/138 (39%), Positives = 84/138 (60%), Gaps = 16/138 (11%)
Query: 335 KKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSF 394
+++ ++ P SQ +AR+K +NC R L VDF+D+GW++WI++P +
Sbjct: 287 RRRAKRSPKHHSQ----------RARKKN----KNCRRHSLYVDFSDVGWNDWIVAPPGY 332
Query: 395 DAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENK 454
A+YC G C FP+ L +NHA +Q++V +V IP+ CCVP ++S++S+L+ DE
Sbjct: 333 QAFYCHGDCPFPLADHLNSTNHAIVQTLVNSVN--SSIPKACCVPTELSAISMLYLDEYD 390
Query: 455 NVVLKVYPNMTVESCACR 472
VVLK Y M VE C CR
Sbjct: 391 KVVLKNYQEMVVEGCGCR 408
>gi|4557369 bone morphogenetic protein 2 preproprotein [Homo
sapiens]
Length = 396
Score = 119 bits (297), Expect = 8e-27
Identities = 54/132 (40%), Positives = 85/132 (64%), Gaps = 3/132 (2%)
Query: 341 GPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCS 400
G K L E+ K ++++ ++ +C R L VDF+D+GW++WI++P + A+YC
Sbjct: 268 GHDGKGHPLHKREKRQAKHKQRKRLKS-SCKRHPLYVDFSDVGWNDWIVAPPGYHAFYCH 326
Query: 401 GACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKV 460
G C FP+ L +NHA +Q++V +V IP+ CCVP ++S++S+L+ DEN+ VVLK
Sbjct: 327 GECPFPLADHLNSTNHAIVQTLVNSVN--SKIPKACCVPTELSAISMLYLDENEKVVLKN 384
Query: 461 YPNMTVESCACR 472
Y +M VE C CR
Sbjct: 385 YQDMVVEGCGCR 396
>gi|10835091 bone morphogenetic protein 5 preproprotein [Homo
sapiens]
Length = 454
Score = 117 bits (294), Expect = 2e-26
Identities = 52/145 (35%), Positives = 85/145 (58%), Gaps = 7/145 (4%)
Query: 327 QAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSE 386
+A K KN+ + + H+ S + + +KQ C + L V F D+GW +
Sbjct: 316 RAANKRKNQNRNKSSSHQDSSRMS-SVGDYNTSEQKQ-----ACKKHELYVSFRDLGWQD 369
Query: 387 WIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLS 446
WII+P+ + A+YC G C FP+ + +NHA +Q++V + +P+PCC P K++++S
Sbjct: 370 WIIAPEGYAAFYCDGECSFPLNAHMNATNHAIVQTLVHLM-FPDHVPKPCCAPTKLNAIS 428
Query: 447 ILFFDENKNVVLKVYPNMTVESCAC 471
+L+FD++ NV+LK Y NM V SC C
Sbjct: 429 VLYFDDSSNVILKKYRNMVVRSCGC 453
>gi|4503969 growth differentiation factor 5 preproprotein [Homo
sapiens]
Length = 501
Score = 115 bits (287), Expect = 1e-25
Identities = 48/103 (46%), Positives = 71/103 (68%), Gaps = 1/103 (0%)
Query: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVV 429
C+R+ L V+F D+GW +WII+P ++A++C G C+FP+ L+P+NHA IQ+++ ++
Sbjct: 400 CSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMD-P 458
Query: 430 PGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
P CCVP ++S +SILF D NVV K Y +M VESC CR
Sbjct: 459 ESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR 501
>gi|48475062 growth differentiation factor 6 precursor [Homo
sapiens]
Length = 455
Score = 115 bits (287), Expect = 1e-25
Identities = 54/145 (37%), Positives = 87/145 (60%), Gaps = 6/145 (4%)
Query: 329 PEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWI 388
P + + + P R+ + F + K+ +K + C+++ L V+F ++GW +WI
Sbjct: 316 PSGAPDARPWLPSPGRRRRRTAFASRHGKRHGKKSRLR---CSKKPLHVNFKELGWDDWI 372
Query: 389 ISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPG-IPEPCCVPEKMSSLSI 447
I+P ++AY+C G C FP+ L+P+NHA IQ+++ ++ PG P CCVP K++ +SI
Sbjct: 373 IAPLEYEAYHCEGVCDFPLRSHLEPTNHAIIQTLMNSMD--PGSTPPSCCVPTKLTPISI 430
Query: 448 LFFDENKNVVLKVYPNMTVESCACR 472
L+ D NVV K Y +M VESC CR
Sbjct: 431 LYIDAGNNVVYKQYEDMVVESCGCR 455
>gi|29571106 bone morphogenetic protein 8B preproprotein [Homo
sapiens]
Length = 402
Score = 114 bits (285), Expect = 2e-25
Identities = 52/152 (34%), Positives = 85/152 (55%), Gaps = 8/152 (5%)
Query: 320 PYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDF 379
P +T +A P + + KK + P FD+ R+ C R L V F
Sbjct: 258 PIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV-------CRRHELYVSF 310
Query: 380 ADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVP 439
D+GW +W+I+P+ + AYYC G C FP+ + +NHA +QS+V + + +P+ CC P
Sbjct: 311 QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLM-MPDAVPKACCAP 369
Query: 440 EKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
K+S+ S+L++D + NV+L+ + NM V++C C
Sbjct: 370 TKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|4502427 bone morphogenetic protein 7 precursor [Homo sapiens]
Length = 431
Score = 113 bits (283), Expect = 3e-25
Identities = 49/135 (36%), Positives = 79/135 (58%), Gaps = 1/135 (0%)
Query: 337 KQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDA 396
KQR K+ Q + A + + C + L V F D+GW +WII+P+ + A
Sbjct: 297 KQRSQNRSKTPKNQEALRMANVAENSSSDQRQACKKHELYVSFRDLGWQDWIIAPEGYAA 356
Query: 397 YYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNV 456
YYC G C FP+ + +NHA +Q++V + +P+PCC P +++++S+L+FD++ NV
Sbjct: 357 YYCEGECAFPLNSYMNATNHAIVQTLVHFIN-PETVPKPCCAPTQLNAISVLYFDDSSNV 415
Query: 457 VLKVYPNMTVESCAC 471
+LK Y NM V +C C
Sbjct: 416 ILKKYRNMVVRACGC 430
>gi|61835232 growth differentiation factor 7 preproprotein [Homo
sapiens]
Length = 450
Score = 113 bits (283), Expect = 3e-25
Identities = 47/103 (45%), Positives = 70/103 (67%), Gaps = 1/103 (0%)
Query: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVV 429
C+R+ L VDF ++GW +WII+P ++AY+C G C FP+ L+P+NHA IQ+++ ++
Sbjct: 349 CSRKPLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLEPTNHAIIQTLLNSM-AP 407
Query: 430 PGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
P CCVP ++S +SIL+ D NVV K Y +M VE+C CR
Sbjct: 408 DAAPASCCVPARLSPISILYIDAANNVVYKQYEDMVVEACGCR 450
>gi|145611428 bone morphogenetic protein 8A [Homo sapiens]
Length = 402
Score = 113 bits (282), Expect = 4e-25
Identities = 52/152 (34%), Positives = 84/152 (55%), Gaps = 8/152 (5%)
Query: 320 PYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRNCARRYLKVDF 379
P +T +A P + + KK + P FD+ R+ C R L V F
Sbjct: 258 PIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVRGSHGRQV-------CRRHELYVSF 310
Query: 380 ADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVP 439
D+GW +W+I+P+ + AYYC G C FP+ + +NHA +QS+V + +P+ CC P
Sbjct: 311 QDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLM-KPNAVPKACCAP 369
Query: 440 EKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
K+S+ S+L++D + NV+L+ + NM V++C C
Sbjct: 370 TKLSATSVLYYDSSNNVILRKHRNMVVKACGC 401
>gi|10190670 growth differentiation factor 3 precursor [Homo
sapiens]
Length = 364
Score = 103 bits (257), Expect = 3e-22
Identities = 46/102 (45%), Positives = 67/102 (65%), Gaps = 2/102 (1%)
Query: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVV 429
C R L ++F D+GW +WII+PK F A YC G C F + SL SN+A +Q+++ AV
Sbjct: 264 CHRHQLFINFRDLGWHKWIIAPKGFMANYCHGECPFSLTISLNSSNYAFMQALMHAVD-- 321
Query: 430 PGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
P IP+ C+P K+S +S+L+ D N NV+L+ Y +M V+ C C
Sbjct: 322 PEIPQAVCIPTKLSPISMLYQDNNDNVILRHYEDMVVDECGC 363
>gi|110349792 growth differentiation factor 1 [Homo sapiens]
Length = 372
Score = 97.1 bits (240), Expect = 3e-20
Identities = 45/108 (41%), Positives = 65/108 (60%), Gaps = 7/108 (6%)
Query: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPS----NHATIQSIVRA 425
C R L V F ++GW W+I+P+ F A YC G C P+ S NHA +++++ A
Sbjct: 267 CRARRLYVSFREVGWHRWVIAPRGFLANYCQGQCALPVALSGSGGPPALNHAVLRALMHA 326
Query: 426 VGVVPGIPE-PCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
PG + PCCVP ++S +S+LFFD + NVVL+ Y +M V+ C CR
Sbjct: 327 AA--PGAADLPCCVPARLSPISVLFFDNSDNVVLRQYEDMVVDECGCR 372
>gi|7705308 growth differentiation factor 2 [Homo sapiens]
Length = 429
Score = 93.6 bits (231), Expect = 3e-19
Identities = 42/105 (40%), Positives = 64/105 (60%), Gaps = 2/105 (1%)
Query: 369 NCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGV 428
+C + L+V+F DIGW WII+PK ++AY C G C FP+ + P+ HA +Q++V +
Sbjct: 326 HCQKTSLRVNFEDIGWDSWIIAPKEYEAYECKGGCFFPLADDVTPTKHAIVQTLVH-LKF 384
Query: 429 VPGIPEPCCVPEKMSSLSILFFDENKNVVLKV-YPNMTVESCACR 472
+ + CCVP K+S +S+L+ D+ LK Y M+V C CR
Sbjct: 385 PTKVGKACCVPTKLSPISVLYKDDMGVPTLKYHYEGMSVAECGCR 429
>gi|7656928 bone morphogenetic protein 10 preproprotein [Homo
sapiens]
Length = 424
Score = 90.5 bits (223), Expect = 3e-18
Identities = 42/114 (36%), Positives = 61/114 (53%), Gaps = 1/114 (0%)
Query: 359 ARRKQWIEPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHAT 418
AR ++ + C R L +DF +IGW WII+P ++AY C G C +P+ + L P+ HA
Sbjct: 312 ARIRRNAKGNYCKRTPLYIDFKEIGWDSWIIAPPGYEAYECRGVCNYPLAEHLTPTKHAI 371
Query: 419 IQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
IQ++V + CCVP K+ +SIL+ D+ Y M V C CR
Sbjct: 372 IQALVHLKNSQKA-SKACCVPTKLEPISILYLDKGVVTYKFKYEGMAVSECGCR 424
>gi|154813204 inhibin beta B subunit preproprotein [Homo sapiens]
Length = 407
Score = 88.6 bits (218), Expect = 1e-17
Identities = 41/105 (39%), Positives = 61/105 (58%), Gaps = 4/105 (3%)
Query: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPM---PKSLKPSNHATIQSIVRAV 426
C R+ +DF IGW++WII+P + YC G+C + P S S H + + R
Sbjct: 303 CCRQQFFIDFRLIGWNDWIIAPTGYYGNYCEGSCPAYLAGVPGSAS-SFHTAVVNQYRMR 361
Query: 427 GVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
G+ PG CC+P K+S++S+L+FD+ N+V + PNM VE C C
Sbjct: 362 GLNPGTVNSCCIPTKLSTMSMLYFDDEYNIVKRDVPNMIVEECGC 406
>gi|222352098 nodal precursor [Homo sapiens]
Length = 347
Score = 86.3 bits (212), Expect = 6e-17
Identities = 45/116 (38%), Positives = 64/116 (55%), Gaps = 4/116 (3%)
Query: 358 KARRKQWIEPRN--CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSN 415
K R+ + R+ C + +VDF IGW WII PK ++AY C G C P+ + P+N
Sbjct: 233 KRHRRHHLPDRSQLCRKVKFQVDFNLIGWGSWIIYPKQYNAYRCEGECPNPVGEEFHPTN 292
Query: 416 HATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
HA IQS+++ +P CC P K LS+L+ D N V+L + +M VE C C
Sbjct: 293 HAYIQSLLKRY-QPHRVPSTCCAPVKTKPLSMLYVD-NGRVLLDHHKDMIVEECGC 346
>gi|4504699 inhibin beta A precursor [Homo sapiens]
Length = 426
Score = 84.0 bits (206), Expect = 3e-16
Identities = 50/167 (29%), Positives = 81/167 (48%), Gaps = 5/167 (2%)
Query: 310 KKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRN 369
KK + EE + K + + +K+Q P Q Q ++ ++ RR + +
Sbjct: 259 KKKKKEEEGEGKKKGGGEGGAGADEEKEQSHRPFLMLQARQSEDHPHRRRRRGLECDGKV 318
Query: 370 --CARRYLKVDFADIGWSEWIISPKSFDAYYCSGAC--QFPMPKSLKPSNHATIQSIVRA 425
C ++ V F DIGW++WII+P + A YC G C S H+T+ + R
Sbjct: 319 NICCKKQFFVSFKDIGWNDWIIAPSGYHANYCEGECPSHIAGTSGSSLSFHSTVINHYRM 378
Query: 426 VGVVP-GIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
G P + CCVP K+ +S+L++D+ +N++ K NM VE C C
Sbjct: 379 RGHSPFANLKSCCVPTKLRPMSMLYYDDGQNIIKKDIQNMIVEECGC 425
>gi|4885097 bone morphogenetic protein 15 precursor [Homo sapiens]
Length = 392
Score = 84.0 bits (206), Expect = 3e-16
Identities = 37/107 (34%), Positives = 55/107 (51%), Gaps = 1/107 (0%)
Query: 366 EPRNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRA 425
E C+ ++ F +GW WII+P + YC G C + L NHA IQ+++
Sbjct: 287 ENNQCSLHPFQISFRQLGWDHWIIAPPFYTPNYCKGTCLRVLRDGLNSPNHAIIQNLINQ 346
Query: 426 VGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
+ V +P P CVP K +S+L + N +++ K Y M ESC CR
Sbjct: 347 L-VDQSVPRPSCVPYKYVPISVLMIEANGSILYKEYEGMIAESCTCR 392
>gi|4885261 growth differentiation factor 9 precursor [Homo sapiens]
Length = 454
Score = 82.0 bits (201), Expect = 1e-15
Identities = 101/459 (22%), Positives = 173/459 (37%), Gaps = 101/459 (22%)
Query: 41 TAGGGPDSELQPQDKVSEHMLRLYDRYSTVQAARTPGSLEGGSQPWRPRLLREGNTVRSF 100
+ G G LQP + +M +LY Y+T EG + R L NTVR F
Sbjct: 70 SVGRGGSPRLQPDSRALHYMKKLYKTYATK---------EGIPKSNRSHLY---NTVRLF 117
Query: 101 ----RAAAAETLERKGLY-----IFNLTSLTKSENILSATLYFCIGELGNISLSCPVSGG 151
R A + G+ +FNL +T E++L + L + I ++S S V
Sbjct: 118 TPCTRHKQAPGDQVTGILPSVELLFNLDRITTVEHLLKSVLLYNINN--SVSFSSAVKCV 175
Query: 152 CSHHAQRKHIQIDLSAWTLKFSRNQSQLLGHL--------SVDMAKSHRDIMSWLSKDIT 203
C+ +K ++ S+ LG + K H+ W+ D+T
Sbjct: 176 CN--------------LMIKEPKSSSRTLGRAPYSFTFNSQFEFGKKHK----WIQIDVT 217
Query: 204 QLLRK--AKENEEFLIGFNITSKGRQLPKR-------RLPFPEPYILVYANDAAISEPES 254
LL+ A + N T QL + P +++Y ND
Sbjct: 218 SLLQPLVASNKRSIHMSINFTCMKDQLEHPSAQNGLFNMTLVSPSLILYLND-------- 269
Query: 255 VVSSLQGHRNFPTGTVPKWDSHIRAALSIERRKKRSTGVLLPLQNNELPGAEYQYKKDEV 314
+S Q + ++ S+ +++ S G P Q L +E
Sbjct: 270 --TSAQAYHSW---------------YSLHYKRRPSQG---PDQERSLSAYPVG---EEA 306
Query: 315 WEERKPYKTLQAQAPEKSKNKKKQRKGPHRKSQTLQFDEQTLKKARRKQWIEPRN-CARR 373
E+ + + E ++ K+ GP + + F +Q++ P+N C
Sbjct: 307 AEDGRSSHHRHRRGQETVSSELKKPLGPASFNLSEYF----------RQFLLPQNECELH 356
Query: 374 YLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIP 433
++ F+ + W WI++P ++ YC G C + H +Q+I+ + +P
Sbjct: 357 DFRLSFSQLKWDNWIVAPHRYNPRYCKGDCPRAVGHRYGSPVHTMVQNIIYEK-LDSSVP 415
Query: 434 EPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCACR 472
P CVP K S LS+L + + ++ K Y +M C CR
Sbjct: 416 RPSCVPAKYSPLSVLTIEPDGSIAYKEYEDMIATKCTCR 454
>gi|13899338 activin beta E [Homo sapiens]
Length = 350
Score = 81.3 bits (199), Expect = 2e-15
Identities = 44/116 (37%), Positives = 61/116 (52%), Gaps = 5/116 (4%)
Query: 360 RRKQWIEPRN--CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKS--LKPSN 415
RR EP C RR VDF ++GW +WI+ P+ + YCSG C + S + S
Sbjct: 235 RRTPTCEPATPLCCRRDHYVDFQELGWRDWILQPEGYQLNYCSGQCPPHLAGSPGIAASF 294
Query: 416 HATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
H+ + S+++A P CCVP LS+L+ D N NVV P+M VE+C C
Sbjct: 295 HSAVFSLLKANNPWPA-STSCCVPTARRPLSLLYLDHNGNVVKTDVPDMVVEACGC 349
>gi|5031613 growth differentiation factor 11 precursor [Homo
sapiens]
Length = 407
Score = 77.8 bits (190), Expect = 2e-14
Identities = 38/102 (37%), Positives = 55/102 (53%), Gaps = 8/102 (7%)
Query: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVV 429
C R L VDF GW +WII+PK + A YCSG C++ + P H Q+ R
Sbjct: 313 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGQCEYMFMQKY-PHTHLVQQANPR----- 365
Query: 430 PGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
G PCC P KMS +++L+F++ + ++ P M V+ C C
Sbjct: 366 -GSAGPCCTPTKMSPINMLYFNDKQQIIYGKIPGMVVDRCGC 406
>gi|4885259 myostatin [Homo sapiens]
Length = 375
Score = 76.3 bits (186), Expect = 6e-14
Identities = 39/102 (38%), Positives = 54/102 (52%), Gaps = 8/102 (7%)
Query: 370 CARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVV 429
C R L VDF GW +WII+PK + A YCSG C+F + P H Q+ R
Sbjct: 281 CCRYPLTVDFEAFGW-DWIIAPKRYKANYCSGECEFVFLQKY-PHTHLVHQANPR----- 333
Query: 430 PGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
G PCC P KMS +++L+F+ + ++ P M V+ C C
Sbjct: 334 -GSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGC 374
>gi|5031795 inhibin beta C chain preproprotein [Homo sapiens]
Length = 352
Score = 74.7 bits (182), Expect = 2e-13
Identities = 37/109 (33%), Positives = 57/109 (52%), Gaps = 7/109 (6%)
Query: 368 RNCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMP--KSLKPSNHATIQSIVR- 424
R C R+ VDF +IGW +WII P+ + +C G C + + S H + ++++
Sbjct: 245 RMCCRQEFFVDFREIGWHDWIIQPEGYAMNFCIGQCPLHIAGMPGIAASFHTAVLNLLKA 304
Query: 425 --AVGVVPGIPEPCCVPEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
A G G CCVP LS+L++D + N+V P+M VE+C C
Sbjct: 305 NTAAGTTGG--GSCCVPTARRPLSLLYYDRDSNIVKTDIPDMVVEACGC 351
>gi|208022653 transforming growth factor, beta 2 isoform 1 [Homo
sapiens]
Length = 442
Score = 66.2 bits (160), Expect = 6e-11
Identities = 74/320 (23%), Positives = 130/320 (40%), Gaps = 32/320 (10%)
Query: 173 SRNQSQLLGHLSVDMAKSHRDIMSWLSKDITQLLRKAKE--NEEFLIGFNITSKGRQLPK 230
SR L G+L +R + D++ + + A EF + F + + ++P+
Sbjct: 133 SRQSQVLCGYLDAIPPTFYRPYFRIVRFDVSAMEKNASNLVKAEFRV-FRLQNPKARVPE 191
Query: 231 RRLPFPEPYILVYANDAAISEPESVVSSLQGHR------NFP-TGTVPKWDSHIRAALSI 283
+R+ E Y ++ + D + S + R +F T V +W H L
Sbjct: 192 QRI---ELYQILKSKDLTSPTQRYIDSKVVKTRAEGEWLSFDVTDAVHEWLHHKDRNLGF 248
Query: 284 ERRKKRSTGVLLPLQNNELPGAEYQYKKDEVWEERKPYKTLQAQAPEKSKNKKKQRKGPH 343
+ +P N +P + + + T Q KS KK K PH
Sbjct: 249 KISLHCPCCTFVPSNNYIIPNKSEELEARFAGIDGTSTYTSGDQKTIKSTRKKNSGKTPH 308
Query: 344 RKSQTL---QFDEQTLKKARRKQWIEPR--------NCARRYLKVDFA-DIGWSEWIISP 391
L + + Q + R+K+ ++ NC R L +DF D+GW +WI P
Sbjct: 309 LLLMLLPSYRLESQQTNR-RKKRALDAAYCFRNVQDNCCLRPLYIDFKRDLGW-KWIHEP 366
Query: 392 KSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCVPEKMSSLSILFFD 451
K ++A +C+GAC + + H+ + S+ + PCCV + + L+IL++
Sbjct: 367 KGYNANFCAGACPYLWSSD---TQHSRVLSLYNTIN-PEASASPCCVSQDLEPLTILYY- 421
Query: 452 ENKNVVLKVYPNMTVESCAC 471
K ++ NM V+SC C
Sbjct: 422 IGKTPKIEQLSNMIVKSCKC 441
>gi|4507463 transforming growth factor, beta 2 isoform 2 [Homo
sapiens]
Length = 414
Score = 63.9 bits (154), Expect = 3e-10
Identities = 45/153 (29%), Positives = 73/153 (47%), Gaps = 19/153 (12%)
Query: 331 KSKNKKKQRKGPHRKSQTL---QFDEQTLKKARRKQWIEPR--------NCARRYLKVDF 379
KS KK K PH L + + Q + R+K+ ++ NC R L +DF
Sbjct: 268 KSTRKKNSGKTPHLLLMLLPSYRLESQQTNR-RKKRALDAAYCFRNVQDNCCLRPLYIDF 326
Query: 380 A-DIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGVVPGIPEPCCV 438
D+GW +WI PK ++A +C+GAC + + H+ + S+ + PCCV
Sbjct: 327 KRDLGW-KWIHEPKGYNANFCAGACPYLWSSD---TQHSRVLSLYNTIN-PEASASPCCV 381
Query: 439 PEKMSSLSILFFDENKNVVLKVYPNMTVESCAC 471
+ + L+IL++ K ++ NM V+SC C
Sbjct: 382 SQDLEPLTILYY-IGKTPKIEQLSNMIVKSCKC 413
>gi|4504697 inhibin alpha subunit precursor [Homo sapiens]
Length = 366
Score = 60.8 bits (146), Expect = 3e-09
Identities = 32/106 (30%), Positives = 50/106 (47%), Gaps = 4/106 (3%)
Query: 369 NCARRYLKVDFADIGWSEWIISPKSFDAYYCSGACQFPMPKSLKPSNHATIQSIVRAVGV 428
NC R L + F ++GW WI+ P SF +YC G C +P +L + + +
Sbjct: 261 NCHRVALNISFQELGWERWIVYPPSFIFHYCHGGCGLHIPPNLSLPVPGAPPTPAQPYSL 320
Query: 429 VPGIPEPCC--VPEKMSSLSI-LFFDENKNVVLKVYPNMTVESCAC 471
+PG +PCC +P M L + D + + PN+ + CAC
Sbjct: 321 LPG-AQPCCAALPGTMRPLHVRTTSDGGYSFKYETVPNLLTQHCAC 365
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.133 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,900,798
Number of Sequences: 37866
Number of extensions: 954500
Number of successful extensions: 3763
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 3612
Number of HSP's gapped (non-prelim): 149
length of query: 472
length of database: 18,247,518
effective HSP length: 106
effective length of query: 366
effective length of database: 14,233,722
effective search space: 5209542252
effective search space used: 5209542252
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.