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Search of human proteins with 126012571
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
(4391 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 9106 0.0
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens] 531 e-150
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens] 519 e-146
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens] 517 e-146
gi|118572606 hemicentin 1 [Homo sapiens] 517 e-146
gi|110349719 titin isoform N2-A [Homo sapiens] 464 e-130
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 358 5e-98
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 358 5e-98
gi|38788416 laminin, alpha 1 precursor [Homo sapiens] 353 3e-96
gi|54873613 agrin [Homo sapiens] 329 3e-89
gi|21264602 laminin alpha 5 [Homo sapiens] 324 1e-87
gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens] 313 2e-84
gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens] 313 2e-84
gi|33469931 EGF-like, fibronectin type III and laminin G domains... 296 3e-79
gi|33469929 EGF-like, fibronectin type III and laminin G domains... 296 3e-79
gi|110611156 laminin, gamma 3 precursor [Homo sapiens] 284 1e-75
gi|145309326 laminin, gamma 1 precursor [Homo sapiens] 269 4e-71
gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens] 267 2e-70
gi|58331253 obscurin, cytoskeletal calmodulin and titin-interact... 260 2e-68
gi|148833506 obscurin, cytoskeletal calmodulin and titin-interac... 260 2e-68
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 228 1e-58
gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens] 225 9e-58
gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens] 225 9e-58
gi|144226847 obscurin-like 1 [Homo sapiens] 224 2e-57
gi|139948432 adlican [Homo sapiens] 208 1e-52
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 198 9e-50
gi|13489095 sialoadhesin precursor [Homo sapiens] 185 8e-46
gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo sa... 185 1e-45
gi|19743806 roundabout 1 isoform b [Homo sapiens] 170 3e-41
gi|4506569 roundabout 1 isoform a [Homo sapiens] 170 3e-41
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 9106 bits (23629), Expect = 0.0
Identities = 4391/4391 (100%), Positives = 4391/4391 (100%)
Query: 1 MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDML 60
MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDML
Sbjct: 1 MGWRAAGALLLALLLHGRLLAVTHGLRAYDGLSLPEDIETVTASQMRWTHSYLSDDEDML 60
Query: 61 ADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLE 120
ADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLE
Sbjct: 61 ADSISGDDLGSGDLGSGDFQMVYFRALVNFTRSIEYSPQLEDAGSREFREVSEAVVDTLE 120
Query: 121 SEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTS 180
SEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTS
Sbjct: 121 SEYLKIPGDQVVSVVFIKELDGWVFVELDVGSEGNADGAQIQEMLLRVISSGSVASYVTS 180
Query: 181 PQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLG 240
PQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLG
Sbjct: 181 PQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLG 240
Query: 241 ISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPR 300
ISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPR
Sbjct: 241 ISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPR 300
Query: 301 DYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCP 360
DYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCP
Sbjct: 301 DYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCP 360
Query: 361 TKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR 420
TKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR
Sbjct: 361 TKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASR 420
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE
Sbjct: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
Query: 481 AMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQI 540
AMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQI
Sbjct: 481 AMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFGITSVCQSTRRFRDQI 540
Query: 541 RLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPE 600
RLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPE
Sbjct: 541 RLRFDQPDDFKGVNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPE 600
Query: 601 QFLGNKVDSYGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQR 660
QFLGNKVDSYGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQR
Sbjct: 601 QFLGNKVDSYGGSLRYNVRYELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQR 660
Query: 661 QVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHAT 720
QVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHAT
Sbjct: 661 QVQFSEEHWVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHAT 720
Query: 721 SHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHC 780
SHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHC
Sbjct: 721 SHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHC 780
Query: 781 LNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCD 840
LNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCD
Sbjct: 781 LNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCD 840
Query: 841 ACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVG 900
ACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVG
Sbjct: 841 ACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVG 900
Query: 901 RLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAAS 960
RLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAAS
Sbjct: 901 RLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAAS 960
Query: 961 THTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPG 1020
THTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPG
Sbjct: 961 THTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPG 1020
Query: 1021 STPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMA 1080
STPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMA
Sbjct: 1021 STPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMA 1080
Query: 1081 LAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDC 1140
LAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDC
Sbjct: 1081 LAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDC 1140
Query: 1141 DTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQR 1200
DTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQR
Sbjct: 1141 DTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQR 1200
Query: 1201 GTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQG 1260
GTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQG
Sbjct: 1201 GTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQG 1260
Query: 1261 QPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPD 1320
QPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPD
Sbjct: 1261 QPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPD 1320
Query: 1321 GCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGA 1380
GCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGA
Sbjct: 1321 GCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGA 1380
Query: 1381 QLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGN 1440
QLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGN
Sbjct: 1381 QLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGN 1440
Query: 1441 NIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSV 1500
NIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSV
Sbjct: 1441 NIMLVASQPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSV 1500
Query: 1501 PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHC 1560
PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHC
Sbjct: 1501 PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHC 1560
Query: 1561 ELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNP 1620
ELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNP
Sbjct: 1561 ELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNP 1620
Query: 1621 ENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVE 1680
ENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVE
Sbjct: 1621 ENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVE 1680
Query: 1681 VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSD 1740
VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSD
Sbjct: 1681 VHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSD 1740
Query: 1741 AGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP 1800
AGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP
Sbjct: 1741 AGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP 1800
Query: 1801 AYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS 1860
AYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS
Sbjct: 1801 AYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS 1860
Query: 1861 GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRL 1920
GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRL
Sbjct: 1861 GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRL 1920
Query: 1921 PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAA 1980
PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAA
Sbjct: 1921 PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAA 1980
Query: 1981 GVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQV 2040
GVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQV
Sbjct: 1981 GVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQV 2040
Query: 2041 VVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS 2100
VVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS
Sbjct: 2041 VVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS 2100
Query: 2101 RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSS 2160
RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSS
Sbjct: 2101 RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSS 2160
Query: 2161 SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHV 2220
SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHV
Sbjct: 2161 SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHV 2220
Query: 2221 VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK 2280
VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK
Sbjct: 2221 VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK 2280
Query: 2281 RGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGST 2340
RGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGST
Sbjct: 2281 RGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGST 2340
Query: 2341 QPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPA 2400
QPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPA
Sbjct: 2341 QPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPA 2400
Query: 2401 DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLV 2460
DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLV
Sbjct: 2401 DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLV 2460
Query: 2461 AGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI 2520
AGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI
Sbjct: 2461 AGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI 2520
Query: 2521 QQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI 2580
QQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI
Sbjct: 2521 QQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI 2580
Query: 2581 VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT 2640
VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT
Sbjct: 2581 VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT 2640
Query: 2641 VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANN 2700
VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANN
Sbjct: 2641 VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANN 2700
Query: 2701 NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTW 2760
NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTW
Sbjct: 2701 NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTW 2760
Query: 2761 HKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHV 2820
HKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHV
Sbjct: 2761 HKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHV 2820
Query: 2821 PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRL 2880
PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRL
Sbjct: 2821 PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRL 2880
Query: 2881 NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ 2940
NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ
Sbjct: 2881 NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ 2940
Query: 2941 TLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE 3000
TLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE
Sbjct: 2941 TLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE 3000
Query: 3001 QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN 3060
QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN
Sbjct: 3001 QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN 3060
Query: 3061 QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG 3120
QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG
Sbjct: 3061 QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG 3120
Query: 3121 PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDA 3180
PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDA
Sbjct: 3121 PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDA 3180
Query: 3181 GTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPA 3240
GTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPA
Sbjct: 3181 GTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPA 3240
Query: 3241 PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3300
PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY
Sbjct: 3241 PTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3300
Query: 3301 ATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDS 3360
ATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDS
Sbjct: 3301 ATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDS 3360
Query: 3361 GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420
GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH
Sbjct: 3361 GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420
Query: 3421 CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQ 3480
CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQ
Sbjct: 3421 CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQ 3480
Query: 3481 LVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVV 3540
LVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVV
Sbjct: 3481 LVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVV 3540
Query: 3541 RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASG 3600
RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASG
Sbjct: 3541 RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASG 3600
Query: 3601 YPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE 3660
YPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE
Sbjct: 3601 YPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE 3660
Query: 3661 RVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ 3720
RVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ
Sbjct: 3661 RVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ 3720
Query: 3721 PDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVN 3780
PDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVN
Sbjct: 3721 PDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVN 3780
Query: 3781 GTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAH 3840
GTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAH
Sbjct: 3781 GTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAH 3840
Query: 3841 GISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCV 3900
GISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCV
Sbjct: 3841 GISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCV 3900
Query: 3901 NRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPL 3960
NRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPL
Sbjct: 3901 NRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPL 3960
Query: 3961 APDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAER 4020
APDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAER
Sbjct: 3961 APDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAER 4020
Query: 4021 LNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEV 4080
LNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEV
Sbjct: 4021 LNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEV 4080
Query: 4081 SVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLC 4140
SVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLC
Sbjct: 4081 SVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLC 4140
Query: 4141 EHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPG 4200
EHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPG
Sbjct: 4141 EHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPG 4200
Query: 4201 QYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFI 4260
QYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFI
Sbjct: 4201 QYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFI 4260
Query: 4261 SLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSP 4320
SLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSP
Sbjct: 4261 SLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSP 4320
Query: 4321 GPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRA 4380
GPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRA
Sbjct: 4321 GPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRA 4380
Query: 4381 QAGANTRPCPS 4391
QAGANTRPCPS
Sbjct: 4381 QAGANTRPCPS 4391
>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 5065
Score = 531 bits (1368), Expect = e-150
Identities = 568/2143 (26%), Positives = 821/2143 (38%), Gaps = 286/2143 (13%)
Query: 1679 VEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQP 1738
V +H + QG + C SG P + WSRE L V P
Sbjct: 610 VSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAP 669
Query: 1739 SDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSK 1798
DAG Y C N ++ L T+ PS V V G + +C A
Sbjct: 670 EDAGNYSCQATNEVGTDQETVTLYYTDPPSVSAVNAVV-----LVAVGEEAVLVCEASGV 724
Query: 1799 SPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQ 1858
P ++W R + +G L I Q DAGTY C N + G A+ +Q
Sbjct: 725 PPP-RVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVN----ELGDASAEIQ 779
Query: 1859 ASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPG---------GQLPA 1909
+ AP ++ P +TV+ G+ A C ATG P PT+ W G G G+
Sbjct: 780 LA-VGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQPLGLRLGAGRGSR 838
Query: 1910 KAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHA 1969
Q G+L +V P DQA Y+C A + G+ A A L V G P++ S +V
Sbjct: 839 SRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLE 898
Query: 1970 GRTVRLYCRA-AGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVAT 2028
G+ V L C AG P W K+G LPP +R +L + AG Y CVAT
Sbjct: 899 GQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVAT 958
Query: 2029 SPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRG 2088
+ AG+ +++VV PP + ++ EG L CV +G +TW +
Sbjct: 959 NTAGSQHRDVELVV-----QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKET 1013
Query: 2089 GSLP---PHTQVHGS-RLRLPQVSPADSGEYVCRVENGSGPKEASITVSV---------- 2134
+L PH V L + Q S D+G YVC N G + +SV
Sbjct: 1014 NALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVW 1073
Query: 2135 -----------------------LHGTHSGP----SYTPVPGSTRPIRIEPSSS--HVAE 2165
T S P S+ V G P +++P V
Sbjct: 1074 EEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLV 1133
Query: 2166 GQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSG 2225
G+ LDLNCV G Q++W K G L R GS + + +D+G Y C ++G
Sbjct: 1134 GEALDLNCVAEGNPEPQLSWSKDGVVLQGR-GPQGS-VHFAAIRTSDAGRYRCEASNSAG 1191
Query: 2226 PLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL 2285
++A +E V+ P S G+ L C G QVTW K S
Sbjct: 1192 -VDA---WEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPSSE 1247
Query: 2286 PARHQ-----VRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGST 2340
P Q + L++ SPAD+G Y C+A+N V T + + Y S
Sbjct: 1248 PLHGQPGVAVLEEGSLFLASVSPADSGDYECQATN------EVGSTSRRAKLVVYVPPSI 1301
Query: 2341 QPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPV----------------- 2383
+ + + S +A GQ+L L C G ++ W K + V
Sbjct: 1302 REDGRKANVSGMA-GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360
Query: 2384 --RHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRI 2441
R G L + DSG Y CR + + + + SV G V
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEV-- 1418
Query: 2442 ESSSSQVAEGQTLDLNCLVAGQAHAQVTWHK-RGGSLPA----RHQVHGSRLRLLQVTPA 2496
G ++L C +G QV W K R LP + Q G LR+
Sbjct: 1419 -----LGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVG 1473
Query: 2497 DSGEYVCRVVGSSGTQ--EASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLN 2554
D G Y C +G Q + + V + GS+ E+ ++ H + L
Sbjct: 1474 DEGRYQCVAFSPAGQQARDFQLRVHAPPTIWGSN----------ETGEVAVMEDHLVQLL 1523
Query: 2555 CLVASQAPHTITWYKRGGSLPSRHQIV----GSRLRIPQVTPADSGEYVCHVSNGAGSRE 2610
C ITW+K G LP+ ++V G +L++ + +D+G Y C SN G+ E
Sbjct: 1524 CEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAE 1583
Query: 2611 TSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVE---GQTLDLNCVVARQPQAIITWYKRG 2667
+ + + V P I P VV+ G+ + L CV P ++W+ G
Sbjct: 1584 KATRLDVY---------VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEG 1634
Query: 2668 ----GSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNID--ALEASIVISVSPSAGSPS 2721
S SR +T GS LRL A SG Y C A++ L+ S+ + V P
Sbjct: 1635 LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAE 1694
Query: 2722 APGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS----HHQTRGSR 2777
G I G+ L+L C G + W + G ++G+
Sbjct: 1695 GLGQVTTI----------VGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTT 1744
Query: 2778 LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSS- 2836
L + HV SG + C+ +G A V V++ + V + P G E SS
Sbjct: 1745 LHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGV-LEVPIGQYHWGXEHHSSF 1803
Query: 2837 ------RVAEGQTLDLK-CVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSG 2889
V G K +V G W + G +P + + P L++ +V D G
Sbjct: 1804 PAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTG-IPVAYSLPPP-LQIEKVDLRDEG 1861
Query: 2890 EYSCQVTGSSG--TLEASVLVTIEPS-SPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNC 2946
Y+C T +G E ++ V + P+ PGP+ + V E ++ L C
Sbjct: 1862 IYTCAATNLAGESKREVALKVLVPPNIEPGPV--------------NKAVLENASVTLEC 1907
Query: 2947 VVPGQAHAQVTWYKRGGSLPARH------QTHGSQLRLHLVSPADSGEYVCRAASGPG-P 2999
+ G V+W+K G P G LR+ +D+G Y C A++ G
Sbjct: 1908 LASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGST 1965
Query: 3000 EQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTR 3059
E V VPP L PV+ P T GA +L W
Sbjct: 1966 ELRYGLRVNVPPRITLPPSLPGPVLVNTPVRLTCNA-----------TGAPSPTLMWLKD 2014
Query: 3060 NQELE----DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVS 3115
+ + + P G ++T+ R S+ G Y CVA +A G + V L VH PP++
Sbjct: 2015 GNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI- 2073
Query: 3116 VLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRT-YGLMDSHAVLQISS 3174
+ E V V ++V LEC S P W + LE R L A+LQ+
Sbjct: 2074 LGEELNVSVVANESVALECQSHAMPPPVLSWWK---DGRPLEPRPGVHLSADKALLQVDR 2130
Query: 3175 AKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCS 3234
A DAG Y C A N G ++K + V + P E LTV GH +L C
Sbjct: 2131 ADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFP-----LRESHTLTVREGHPTSLSCE 2185
Query: 3235 ATGSPAPTIHWSKLRSPLP-----WQH-RLEGDTLIIPRVAQQDSGQYICNATSPAGHAE 3288
G P P I W K PLP QH G L + + G Y C ++ G++
Sbjct: 2186 CRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSS 2245
Query: 3289 ATIILHVESPPYAT---TVPEHASVQAGETVQLQCLAHGTPPLTFQWSR----VGSSLPG 3341
+ L V PP P SV L+C A G PP T W R VG+ L
Sbjct: 2246 QDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGL 2305
Query: 3342 RATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP---GSL-PATSIPAG 3397
+ + + LH ERA +GRY C N G AE +L V PP G L P T+I
Sbjct: 2306 QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNI--- 2362
Query: 3398 STPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ----DGVLRI 3453
T ++ + + C +RWF+ + PG +L++
Sbjct: 2363 ------------TAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKM 2410
Query: 3454 QNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLAL 3513
+ G Y C A G+A+ + + + PS+ V V+ G C
Sbjct: 2411 TQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVT 2470
Query: 3514 GDPKPQVTWSKVGGHLRPG----IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVL 3569
G P+P++TW K G L G I G ++++ L+ AG Y C A NA G H
Sbjct: 2471 GHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQ 2530
Query: 3570 LLVQALPQI------SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLEN 3623
L V P I S +EV V + C A +P+P+I+W K DG+ SR
Sbjct: 2531 LSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK-DGAPFEASR--- 2586
Query: 3624 NMLMLP--------SVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
N+ +LP + + +DAG Y C TN G+ H++V
Sbjct: 2587 NIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 2629
Score = 517 bits (1332), Expect = e-146
Identities = 538/2081 (25%), Positives = 820/2081 (39%), Gaps = 252/2081 (12%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAGVYI 1745
V G + L C V+G P W + DGRP+ G G L S AG Y
Sbjct: 2457 VLDGQTAHLMCNVTGHPQPKLTWFK-DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 2515
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
C N T +L V AP+ +V ++ IC A + P+ +
Sbjct: 2516 CIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALA-FPSPNIT 2574
Query: 1806 WTR---LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA--- 1859
W + + + L I N Q DAG Y C +N + + HV+
Sbjct: 2575 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN--ELGEAVKNYHVEVLIP 2632
Query: 1860 -SGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPA-KAQI--HG 1915
S + P+ + ++ + C + P PT+ W P+ + Q+ G
Sbjct: 2633 PSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG 2692
Query: 1916 GILRLPAVEPTDQAQYLCRAHSSAGQ--QVARAVLHVH------GGGGPRVQVSPERTQV 1967
+L++ + +D +YLC A + AG+ Q ++ V G ++ +
Sbjct: 2693 RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 2752
Query: 1968 HAGRT----------VRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA----TLLIP 2013
G T LYC +P +TW +E P + + + L IP
Sbjct: 2753 RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED---QPLSAGDEVSVLQGGRVLQIP 2809
Query: 2014 AITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTE-----GQTL 2068
+ +AG Y C A++ G +++VL+ PPV + + V E T+
Sbjct: 2810 LVRAENAGRYSCKASNEVGEDWLHYELLVLT------PPVILGDTEELVEEVTVNASSTV 2863
Query: 2069 DLNCVVAGSAHAQVTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSG 2124
L C G+ ++W + G P ++ G L++ AD+ Y+C EN +G
Sbjct: 2864 SLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG 2923
Query: 2125 PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVT 2184
E T+ V VP + +E ++ + ++ L C V + +VT
Sbjct: 2924 SAEKLFTLRV-----------QVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 2970
Query: 2185 WHKRGGSLPARHQ------THGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238
W+K +L + TH L+L + +DSG Y C + +G LV +
Sbjct: 2971 WYKDSQALSLGEEVFLLPGTH--TLQLGRARLSDSGMYTCEALNAAG--RDQKLVQLSVL 3026
Query: 2239 VIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR----GS 2294
V P R + V G LSC VTWYK G L + + G
Sbjct: 3027 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 3086
Query: 2295 RLYIFQASPADAGQYVCRASN-GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVA 2353
RL I +A +D G Y C+ SN EA T T+T P T SQVA
Sbjct: 3087 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETV--------SQVA 3138
Query: 2354 EGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ------THGSLLRLYQASPADSGEYVC 2407
G L L C V G VTW K +PV + G L+L + PA +G Y C
Sbjct: 3139 -GSPLVLTCDVSGVPAPTVTWLK--DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTC 3195
Query: 2408 RVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQ 2467
+ +V + A + + GV + V EGQ + L+C GQ
Sbjct: 3196 VAENTQAEARKDFVVAVLVAPRIRSSGV-------AREHHVLEGQEVRLDCEADGQPPPD 3248
Query: 2468 VTWHKRGGSLPA------RHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQ 2521
V W K G L R + G L L + +D+G Y C +G E + L T+
Sbjct: 3249 VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG--EDARLHTVN 3306
Query: 2522 QRLSGSHSQGVAYPVRIESSSASLAN--GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQ 2579
+ + QG S +L + G + + C V P ++W K G LP +
Sbjct: 3307 VLVPPTIKQGA-------DGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQR 3359
Query: 2580 IV----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIE 2635
+ G LRI +V AD+G + C ++ AG + + + +Q VP V P+ +
Sbjct: 3360 TLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ------VPPVLEPVEFQ 3413
Query: 2636 SSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYV 2695
+ VV G ++L C P +++W K G L S+ G L+L + DSG Y
Sbjct: 3414 NDV-VVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYS 3472
Query: 2696 CRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH 2755
C A + ++V P S P + + G ++L C G
Sbjct: 3473 CVAVSEAGEARRHFQLTVMEP---PHIEDSGQPTELS-----LTPGAPMELLCDAQGTPQ 3524
Query: 2756 AQVTWHKRGGSLPS-HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASG 2814
+TWHK G +L + +R +R+ + D+G Y C +G +E S V ++A
Sbjct: 3525 PNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAESPAGAIEKSFRVRVQA-- 3578
Query: 2815 SSAVHVPAPGGAPPIRIEPSSSR----VAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP-- 2868
PP + P R +A GQ L L+C V + ++TWH+ G L
Sbjct: 3579 ------------PPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQED 3625
Query: 2869 --ARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQP 2926
+ G L+L +S ADSG+YSC ++G+ + V I +P P
Sbjct: 3626 AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT-----VPTIRSGPP 3680
Query: 2927 IYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHG----SQLRLHLVS 2982
+ +V+ QT L C G V+W K L R LR+ V
Sbjct: 3681 ------AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVL 3734
Query: 2983 PADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFK 3042
D+G Y+C A++ G +++ + P P I+ P + T+ A
Sbjct: 3735 AQDAGHYLCLASNSAGSDRQGRDLRVLEP----------PAIAPSPSNLTLTAHTPALLP 3784
Query: 3043 CLIHDGAAPISLEWKTRNQELEDNVH------ISPNGSIITIVGTRPSNHGTYRCVASNA 3096
C P+ + WK Q+L+ + + N ++T G P + + CV SN
Sbjct: 3785 CEASGSPKPLVVWWKD-GQKLDFRLQQGAYRLLPSNALLLTAPG--PQDSAQFECVVSNE 3841
Query: 3097 YGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKL 3156
G A + ++VH PPT++ + V + V L C S G P + W++ A+L
Sbjct: 3842 VGEAHRLYQVTVHVPPTIAD-DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAG---AQL 3897
Query: 3157 EQRTYGLMDSHA-VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQ 3215
R G S + L+I A P AG Y C A+N+ G A K V + V + P V
Sbjct: 3898 GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVV 3957
Query: 3216 AEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSPLPWQHRLEGDTLIIPRVAQQ 3271
AE V L C A+G P PTI W K + + + Q L G L I + +
Sbjct: 3958 RAVAEEEV------LLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQLRIAHASPE 4010
Query: 3272 DSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQ 3331
D+G Y+C A + AG A L V+ PP S G L C A G+P
Sbjct: 4011 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT 4070
Query: 3332 WSRVG---SSLPGRATAR--NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 3386
W + G S G+ T + ELL + +D+G Y C N VG A L +
Sbjct: 4071 WDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRARRRVHLTIL--- 4126
Query: 3387 GSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV 3446
P P + +G + CA ++ W + G S
Sbjct: 4127 -----------VLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE 4175
Query: 3447 QDGVLRIQN--LDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGH 3504
QDG +Q + + GTY+C A G+ QA + + ++ P VL S VG
Sbjct: 4176 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGG 4234
Query: 3505 AVEFECLALGDPKPQVTWSKVGGHLRPGIVQ---SGGVVRIAHVELADAGQYRCTATNAA 3561
+++ +C+ GDP P + W K G LR ++ G + I E DAG+Y+C A N
Sbjct: 4235 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEM 4294
Query: 3562 GTTQSHVLLLVQALPQISM-PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR 3620
G + V+L++Q+ P + PQ++ V +G C A+G PTP I W + L R
Sbjct: 4295 GVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRR 4354
Query: 3621 LE---NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
L + L L +V DAGTY C A N G A A L V
Sbjct: 4355 LRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 4395
Score = 511 bits (1315), Expect = e-144
Identities = 573/2198 (26%), Positives = 848/2198 (38%), Gaps = 338/2198 (15%)
Query: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGS 1693
G Y CTA TG+ Q V +P Q +P N V V P + V
Sbjct: 492 GTYECTAVSRAGTGRAKAQI---VVTDPPPQ---LVPAPN-----VTVSPGETAV----- 535
Query: 1694 HSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSEL--HFPSVQPSDAGVYICTCRNL 1751
L C+V G P+ W R D R +P+ T + Q ++L + P+D G Y C N
Sbjct: 536 --LSCRVLGEAPYNLTWVR-DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 592
Query: 1752 HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
+ + LLV EAP I + SQ G +V C+A S P + W+R
Sbjct: 593 NGVTRASVWLLVREAPQVSIHTS-----SQHFSQGVEVKVSCSA-SGYPTPHISWSRESQ 646
Query: 1812 GKLPTRAM--DFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVS 1869
+ D G L I+ V DAG Y C +N DQ T TL+ P VS
Sbjct: 647 ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY-----TDPPSVS 701
Query: 1870 IHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQA 1929
+ V G+ A C A+G P P + W G + A G LR+PA + D
Sbjct: 702 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAG 761
Query: 1930 QYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITW 1989
Y CRA + G A L V G P++ P V GR+ L CRA G P T+TW
Sbjct: 762 TYTCRAVNELGDASAEIQLAV--GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW 819
Query: 1990 RKEGG-------SLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVV 2042
R+ G +RS + D L ++ D Y+C A + G QA +++V
Sbjct: 820 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 879
Query: 2043 LSASDASPPPVKIESSSPSVTEGQTLDLNCVV-AGSAHAQVTWYRRGGSLPP---HTQVH 2098
+ +PP + + + V EGQ + L C+V AG + W + G LPP H+
Sbjct: 880 ---TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA 936
Query: 2099 GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP 2158
L L + +G Y C N +G + + + V P RI P
Sbjct: 937 DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV----------------QVPPRIHP 980
Query: 2159 SSSH--VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH-----QTHGSLLRLHQVTPA 2211
+++H EG L CV G +TW K +L +R G+LL + Q +
Sbjct: 981 TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQ 1039
Query: 2212 DSGEYVCHVVGTSG-----------PLEASVLVTIEASVIPG------------------ 2242
D+G YVC T G L S V E ++P
Sbjct: 1040 DAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYEC 1099
Query: 2243 -----------------PIPP-VRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS 2284
+PP V+ V G+ LDL+CV G Q++W K G
Sbjct: 1100 TASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVV 1159
Query: 2285 LPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEA-SITVTVTGTQGANLAYPAGSTQ 2341
L R +GS ++ +DAG+Y C ASN G++A + + V +G +
Sbjct: 1160 LQGRGP-QGS-VHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWGADETSGLLE 1217
Query: 2342 PIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ------THGSLLRLY 2395
+ G+ L C G QVTW K S P+ Q GSL L
Sbjct: 1218 RV----------AGENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLF-LA 1266
Query: 2396 QASPADSGEYVCRVLG--SSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVA--EG 2451
SPADSG+Y C+ S A ++V V P++R + + V+ G
Sbjct: 1267 SVSPADSGDYECQATNEVGSTSRRAKLVVY-----------VPPSIREDGRKANVSGMAG 1315
Query: 2452 QTLDLNCLVAGQAHAQVTWHK-----------------RGGSLPARHQV--HGSRLRLLQ 2492
Q+L L C G ++ W K G H++ G L +
Sbjct: 1316 QSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPR 1375
Query: 2493 VTPADSGEYVCRVVGSSGT--QEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHT 2550
+ DSG Y CR +GT ++ +LV + G+ G A V LA G
Sbjct: 1376 IQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGA---GAAQEV------LGLA-GAD 1425
Query: 2551 LDLNCLVASQAPHTITWYK-RGGSLPS----RHQIVGSRLRIPQVTPADSGEYVCHVSNG 2605
++L C + + W K R LP + Q G LRI D G Y C +
Sbjct: 1426 VELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSP 1485
Query: 2606 AGSRETSLIVTIQGSGSSHVPSVSPPI--RIESSSPTVVEGQTLDLNCVVARQPQAIITW 2663
AG + + + H P P I E+ V+E + L C P ITW
Sbjct: 1486 AGQQARDFQLRV------HAP---PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 1536
Query: 2664 YKRGGSLPSR----HQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGS 2719
+K G LP+ + G L+L + +D+G Y C+A+N + A E + + V
Sbjct: 1537 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTI 1596
Query: 2720 PSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRG----GSLPSHHQTRG 2775
A G ++ G + L CV G ++WH G S S +T G
Sbjct: 1597 EGAGGRPYVVK-------AVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG 1649
Query: 2776 SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSS 2835
S LRL A SG Y C + SS EA + ++E V VP P + +
Sbjct: 1650 SVLRLESPGEASSGLYSC--VASSPAGEAVLQYSVE------VQVP-----PQLLVAEGL 1696
Query: 2836 SRVAE--GQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQV------HGPLLRLNQVSPAD 2887
+V GQ L+L C G + W + G PA G L ++ V
Sbjct: 1697 GQVTTIVGQPLELPCQASGSPVPTIQWLQNG--RPAEELAGVQVASQGTTLHIDHVELDH 1754
Query: 2888 SGEYSCQVTGSSGTLEASVLVTIEPS-SPGPIPA---------------PGLAQPIYIEA 2931
SG ++CQ T +GT A V V++ +PG + P P
Sbjct: 1755 SGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRG 1814
Query: 2932 SSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVC 2991
+H L PG + T SLP L++ V D G Y C
Sbjct: 1815 WGAH--PKPPLVEGWCSPGSLWGEPTGIPVAYSLP-------PPLQIEKVDLRDEGIYTC 1865
Query: 2992 RAASGPG-PEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAA 3050
A + G ++E + V VPP+ I P + V + + +CL G
Sbjct: 1866 AATNLAGESKREVALKVLVPPN-----------IEPGPVNKAVLENASVTLECLA-SGVP 1913
Query: 3051 PISLEWKTRNQELED--NVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV 3108
P + W +Q + V +S +G ++ I + S+ G+YRCVASN G + L V
Sbjct: 1914 PPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV 1973
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHA 3168
+ PP +++ P P V V V L C + G P + W + + + +
Sbjct: 1974 NVPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR 2033
Query: 3169 VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHT 3228
VL ++SA+ SD+G Y C+A +A+G ++ V + V P + EE ++V A +
Sbjct: 2034 VLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHM------PPSILGEELNVSVVANES 2087
Query: 3229 ATLRCSATGSPAPTIHWSKLRSPL---PWQHRLEGDTLI-IPRVAQQDSGQYICNATSPA 3284
L C + P P + W K PL P H L+ + R D+G Y C A + A
Sbjct: 2088 VALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQA 2147
Query: 3285 GHAEATIILHVESPPYATTVPEHA-SVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG-- 3341
GH+E L+V P H +V+ G L C G P W + G LPG
Sbjct: 2148 GHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEG 2207
Query: 3342 ----RATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAG 3397
+A LL+ +A G Y C +N VG++ QL V PP I
Sbjct: 2208 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPP------QIAGP 2261
Query: 3398 STPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKE----GGQLPPGHSVQDGVLRI 3453
P QV+ + C + W ++ G +L Q L +
Sbjct: 2262 REPPTQVSVVQD-----GVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHV 2316
Query: 3454 QNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHA-VEFECLA 3512
+ + G Y C A G+A+ +L + P ++ ++ H+ + C A
Sbjct: 2317 ERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEA 2376
Query: 3513 LGDPKPQVTWSKVGGHLRPG----IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHV 3568
+G P P + W + + PG ++ G ++++ + D+G Y C A+N AG + +
Sbjct: 2377 MGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNF 2436
Query: 3569 LLLVQALPQI---SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDG---------SLP 3616
+ V P I + + ++V G A C +G+P P ++W K DG +
Sbjct: 2437 SVEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFK-DGRPLARGDAHHIS 2495
Query: 3617 PDSRLENNMLMLPSVRPQDAGTYVCTATNRQG-KVKAF 3653
PD L L + AG Y C A N G K K F
Sbjct: 2496 PDGVL----LQVLQANLSSAGHYSCIAANAVGEKTKHF 2529
Score = 490 bits (1261), Expect = e-137
Identities = 538/2116 (25%), Positives = 814/2116 (38%), Gaps = 270/2116 (12%)
Query: 1683 PARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPS--GTQQRHQGSELHFPSVQPSD 1740
P + V Q G +L C +G PP W R DG+PV + G Q ++QG LH Q +
Sbjct: 2265 PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAH 2323
Query: 1741 AGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP 1800
G Y C NL + EL V P + ++ + + + +T +C A P
Sbjct: 2324 TGRYSCVAENLAGRAERKFELSVLVPPE--LIGDLDPLTNITAALHSPLTLLCEAMGIPP 2381
Query: 1801 AYTLVWTRLHNGKLP---TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV 1857
+ W R P T + +L + Q D+G Y C SN + ++ V
Sbjct: 2382 P-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 2440
Query: 1858 QASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH--- 1914
++ + + V GQ A C+ TG P P L W G+ A+ H
Sbjct: 2441 LVPPSIENEDLE---EVIKVLDGQTAHLMCNVTGHPQPKLTWF--KDGRPLARGDAHHIS 2495
Query: 1915 --GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGG---GPRVQVSPERTQVHA 1969
G +L++ + Y C A ++ G++ L V G + E V
Sbjct: 2496 PDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 2555
Query: 1970 GRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT----LLIPAITTADAGFYLC 2025
+ L C A PS ITW K+G P S + L I DAG Y C
Sbjct: 2556 NNPISLICEALAFPSPNITWMKDGA---PFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 2612
Query: 2026 VATSPAGTAQARIQVVVLSASDASP--PPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2083
V T+ G A V VL S P ++ TL L C +
Sbjct: 2613 VVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR 2672
Query: 2084 WYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTH 2139
WY+ G + P +++ G L++ +DSG Y+C N +G + V +
Sbjct: 2673 WYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----Q 2728
Query: 2140 SGPSYTPVPGSTRPIRIEPSSSHVAEGQT--------------LDLNCVVPGQAHAQVTW 2185
P + V + I G T D N + P +TW
Sbjct: 2729 VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPP----PDLTW 2784
Query: 2186 HKRGGSLPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGP--LEASVLVTIEASV 2239
++ L A + G +L++ V ++G Y C G L +LV
Sbjct: 2785 YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT---- 2840
Query: 2240 IPGPIPPVRIESSSSTVAE-----GQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR-- 2292
PPV + + V E T+ L C G ++W + G LP R
Sbjct: 2841 -----PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQ 2893
Query: 2293 ----GSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPS 2348
G L + A ADA Y+C A N ++ + Q Q I S
Sbjct: 2894 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNS 2953
Query: 2349 SSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ------THGSLLRLYQASPADS 2402
S + L C V + +VTW+K +L + + TH L+L +A +DS
Sbjct: 2954 S--------VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH--TLQLGRARLSDS 3003
Query: 2403 GEYVCRVLGSSVP----LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC 2458
G Y C L ++ ++ SVLV PA P R + V G L+C
Sbjct: 3004 GMYTCEALNAAGRDQKLVQLSVLVP-------PAFRQAP--RGPQDAVLVRVGDKAVLSC 3054
Query: 2459 LVAGQAHAQVTWHKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCRVVGSSGTQEA 2514
VTW+K G L + G RL + + +D G Y C+V +G
Sbjct: 3055 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 3114
Query: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL 2574
+ +T+Q + + + + + S G L L C V+ T+TW K +
Sbjct: 3115 TFTLTVQVPPTFENPK---------TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV 3165
Query: 2575 PSR--HQIV--GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
S H +V G RL++ ++ PA +G Y C N +V + V+P
Sbjct: 3166 ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVL---------VAP 3216
Query: 2631 PIRIESSSPT--VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH------GSHLR 2682
IR + V+EGQ + L+C QP + W K G L H G L
Sbjct: 3217 RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLV 3276
Query: 2683 LHQMSVADSGEYVCRANNNI--DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAE 2740
L + +D+G Y C A+N DA ++ + V P+ A GS +
Sbjct: 3277 LKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTI-KQGADGSGTLVS--------RP 3327
Query: 2741 GETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT----RGSRLRLHHVSPADSGEYVCRVM 2796
GE + + C V G V+W K G LP +T G LR+ V AD+G + C
Sbjct: 3328 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 3387
Query: 2797 GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSR----VAEGQTLDLKCVVPG 2852
+G + + + ++ PP+ +EP + V G ++L C G
Sbjct: 3388 SPAGVADRNFTLQVQV--------------PPV-LEPVEFQNDVVVVRGSLVELPCEARG 3432
Query: 2853 QAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEP 2912
V+W K G L ++ GP L+L V DSG YSC +G +T+
Sbjct: 3433 VPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-- 3490
Query: 2913 SSPGPIPAPGLAQPIYIEASSS----HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR 2968
+P +IE S +T G ++L C G +TW+K G +L R
Sbjct: 3491 -----------MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-TR 3538
Query: 2969 HQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV--PPSEGSSYRLRSP--VI 3024
+ + R+ V D+G Y C A S P E SF V V PP+ R P V+
Sbjct: 3539 LENNSRATRVLRVR--DAGLYTCLAES-PAGAIEKSFRVRVQAPPNIVGP---RGPRFVV 3592
Query: 3025 SIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTR 3082
+ P ++ C + AP + W L+++ H G + +
Sbjct: 3593 GLAPGQLVLE--------CSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALS 3643
Query: 3083 PSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRS 3142
++ G Y C A NA G + +H PT+ P V V V + L C + G P
Sbjct: 3644 TADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPA-VNVSVNQTALLPCQADGVPAP 3702
Query: 3143 SARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV-I 3201
W R P + ++ + L+I DAG Y+CLA N+ G+ ++ ++ +
Sbjct: 3703 LVSW-RKDRVPLDPRSPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV 3760
Query: 3202 VDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR---- 3257
++ A+AP + LT+ A A L C A+GSP P + W K L ++ +
Sbjct: 3761 LEPPAIAPSP-------SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY 3813
Query: 3258 --LEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGET 3315
L + L++ QDS Q+ C ++ G A + V PP +V
Sbjct: 3814 RLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP 3873
Query: 3316 VQLQCLAHGTPPLTFQWSRVGSSLPGRAT----ARNELLHFERAAPEDSGRYRCRVTNKV 3371
V L C + G P T WS+ G+ L R + + + L +A P +GRY C N
Sbjct: 3874 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 3933
Query: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQL 3431
G A L VQ ++P V+ P + V C +
Sbjct: 3934 GVAHKHVFLTVQ--------------ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTI 3979
Query: 3432 RWFKEGGQLPPGHSVQ---DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
W KEG + G S Q G LRI + G Y+C A G A +LV+Q +P
Sbjct: 3980 TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ-VPP 4038
Query: 3489 VLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK----VGGHLRPGIVQSGGVVRIAH 3544
V+ N + T HA C A G P+P +TW K V G +Q G + + +
Sbjct: 4039 VIENGLPDLSTTEGSHAF-LPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 4097
Query: 3545 VELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVFPCIASGYPT 3603
+E DAG Y CTA NA G + V L + LP + +P + + G C A G PT
Sbjct: 4098 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 4157
Query: 3604 PDISWSKLDGSLPPDSRLEN--NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPER 3661
P I W+ D + ++ + L +V +D+GTYVC A NR G+ +A + + V E
Sbjct: 4158 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE- 4216
Query: 3662 VVPYFTQTPYSFLPLP 3677
P +S+L P
Sbjct: 4217 -APVLQGEAFSYLVEP 4231
Score = 489 bits (1259), Expect = e-137
Identities = 525/1981 (26%), Positives = 792/1981 (39%), Gaps = 238/1981 (12%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQ-QRHQGSE-LHFPSVQPSDAGVYICTCRNL- 1751
SL C+ P W + DG P + Q G+ L + Q DAG Y C N
Sbjct: 2560 SLICEALAFPSPNITWMK-DGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNEL 2618
Query: 1752 -HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLH 1810
E+L+ + SK + + + + +T C + + P T+ W +
Sbjct: 2619 GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPP-TIRWYKDG 2677
Query: 1811 NGKLPTRAMDFNG---ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS------G 1861
P+ + G +L I+ Q+SD+G Y+C +N+ D + +Q G
Sbjct: 2678 QPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVG 2737
Query: 1862 TLSAPVVSIHPPQLTVQPGQLAEFR-----------CSATGSPTPTLEW--TGGPGGQLP 1908
SA + + G + E+R C P P L W P
Sbjct: 2738 DFSAAFEILSREEEA--RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 2795
Query: 1909 AKAQIHGG-ILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP----- 1962
+ + GG +L++P V + +Y C+A + G+ L V P V +
Sbjct: 2796 EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT---PPVILGDTEELV 2852
Query: 1963 ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE-RTDIATLLIPAITTADAG 2021
E V+A TV L C A G P TI+W + G P R + D L + ADA
Sbjct: 2853 EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAA 2912
Query: 2022 FYLCVATSPAGTAQA----RIQVVVLSASDASPPPVK-IESSSPSVTEGQTLDLNCVVAG 2076
Y+CVA + AG+A+ R+QV PP + ++ + ++ L C V
Sbjct: 2913 SYMCVAENQAGSAEKLFTLRVQV---------PPRIAGLDLEQVTAILNSSVSLPCDVHA 2963
Query: 2077 SAHAQVTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITV 2132
+ +VTWY+ +L +V L+L + +DSG Y C N +G + + +
Sbjct: 2964 HPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 3023
Query: 2133 SVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE-GQTLDLNCVVPGQAHAQVTWHKRGGS 2191
SVL VP + R P + + G L+C VTW+K G
Sbjct: 3024 SVL-----------VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 3072
Query: 2192 LPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
L +T G L + + +D G Y C V +G + +T++ +PP
Sbjct: 3073 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ-------VPPT 3125
Query: 2248 RIESSSSTVAE--GQTLDLSCVVAGQAHAQVTWYKRGGSLP--ARHQV--RGSRLYIFQA 2301
+ TV++ G L L+C V+G VTW K + A H V RG RL + +
Sbjct: 3126 FENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRL 3185
Query: 2302 SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLN 2361
PA AG Y C A N + V A +G + V EGQ + L+
Sbjct: 3186 QPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR-------EHHVLEGQEVRLD 3238
Query: 2362 CVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVL 2421
C GQ V W K G L Q G LR Y D G V + L +S A
Sbjct: 3239 CEADGQPPPDVAWLKDGSPLG---QDMGPHLRFY----LDGGSLVLKGLRAS-DAGAYTC 3290
Query: 2422 VTIEPAGSVPALG-----VTPTVR--IESSSSQVAE-GQTLDLNCLVAGQAHAQVTWHKR 2473
V PAG L V PT++ + S + V+ G+ + + C V G V+W K
Sbjct: 3291 VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 3350
Query: 2474 GGSLPA--RHQVHGS--RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHS 2529
G LP R +HGS LR+ +V AD+G + C +G + + + +Q
Sbjct: 3351 GLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV------- 3403
Query: 2530 QGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQ 2589
V PV ++ + G ++L C ++W K G L S+ G L++
Sbjct: 3404 PPVLEPVEFQNDVV-VVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEA 3462
Query: 2590 VTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT---VVEGQT 2646
V DSG Y C + AG +T+ + PP +S PT + G
Sbjct: 3463 VGAGDSGTYSCVAVSEAGEARRHFQLTV----------MEPPHIEDSGQPTELSLTPGAP 3512
Query: 2647 LDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALE 2706
++L C PQ ITW+K G +L +R + + R+ + V D+G Y C A + A+E
Sbjct: 3513 MELLCDAQGTPQPNITWHKDGQAL-TRLENNSRATRV--LRVRDAGLYTCLAESPAGAIE 3569
Query: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGS 2766
S + V P+ G P + +A G+ L L C V + ++TWH+ G
Sbjct: 3570 KSFRVRVQ---APPNIVGPRGPRFVVG----LAPGQ-LVLECSVEAEPAPKITWHRDGIV 3621
Query: 2767 LPSHHQT----RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPA 2822
L T RG L+L +S ADSG+Y C ++G + V I
Sbjct: 3622 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT---------- 3671
Query: 2823 PGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL----L 2878
P IR P + V+ QT L C G V+W K L R L L
Sbjct: 3672 ---VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSL 3728
Query: 2879 RLNQVSPADSGEYSCQVTGSSGT-LEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
R+ V D+G Y C + S+G+ + L +EP + P P S+ +T
Sbjct: 3729 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSP------------SNLTLT 3776
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGP 2997
L C G V W+K G L R Q +L P+++ + P
Sbjct: 3777 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL-----PSNA-----LLLTAP 3826
Query: 2998 GPEQEASFTVTVPPSEGSSYRLRS------PVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
GP+ A F V G ++RL P I+ D TV C AP
Sbjct: 3827 GPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAP 3886
Query: 3052 ISLEWKTRNQELE---DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV 3108
++ W +L +SP+G++ I P + G Y C A N+ GVA V L+V
Sbjct: 3887 -TVSWSKAGAQLGARGSGYRVSPSGAL-EIGQALPIHAGRYTCSARNSAGVAHKHVFLTV 3944
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHA 3168
P V LP V + V L C ++G PR + W + A T L
Sbjct: 3945 QASPVVKPLPS-VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT-GVSTQVLPGGQ- 4001
Query: 3169 VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHT 3228
L+I+ A P DAG Y+C+A+N+ G+A + ++V P ++ +L+ G
Sbjct: 4002 -LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQV------PPVIENGLPDLSTTEGSH 4054
Query: 3229 ATLRCSATGSPAPTIHWSKLRSPLPWQHRL----EGDTLIIPRVAQQDSGQYICNATSPA 3284
A L C A GSP P I W K P+ L++ + QD+G Y C A +
Sbjct: 4055 AFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 4114
Query: 3285 GHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRAT 3344
G A + L + P TT+P S++ G+ + L+C A G+P W+ + +
Sbjct: 4115 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS 4174
Query: 3345 ARNELLHFERAAP--EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTV 3402
++ +RAA EDSG Y C N+VG +A + + V+ P + G +
Sbjct: 4175 EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-------VLQGEAFSY 4227
Query: 3403 QVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGH---SVQDGVLRIQNLDQS 3459
V P +G S++ C V D + W K+G L H +Q+G L I ++
Sbjct: 4228 LVEP------VGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 4281
Query: 3460 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQ 3519
G Y C A G A+ LV+Q+ P + + TV G V C A G+P P
Sbjct: 4282 DAGRYQCLAENEMGVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPT 4339
Query: 3520 VTWSKVGGHLRPGI---VQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALP 3576
+ W + G LR G + + +VE DAG Y C A N G+ + L+V+ P
Sbjct: 4340 IEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399
Query: 3577 Q 3577
Q
Sbjct: 4400 Q 4400
Score = 487 bits (1253), Expect = e-136
Identities = 547/2127 (25%), Positives = 799/2127 (37%), Gaps = 257/2127 (12%)
Query: 1664 QGGQCLPETNQAPLVVEVHPARS----IVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVP 1719
Q G N V V P R V +G SL C+ G P W R+DG+P+P
Sbjct: 2146 QAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLP 2204
Query: 1720 S-GTQQRHQ---GSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTV 1775
G +H G L+ Q + G Y C C N+ +++ +L V P I
Sbjct: 2205 GEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ--IAGPR 2262
Query: 1776 EEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN---GKLPTRAMDFNGILTIRNVQL 1832
E SV T C A K P T+ W R +L + + L + Q
Sbjct: 2263 EPPTQVSVVQDGVATLECNATGKPPP-TVTWERDGQPVGAELGLQLQNQGQSLHVERAQA 2321
Query: 1833 SDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGS 1892
+ G Y C N+ + L V L + + +T C A G
Sbjct: 2322 AHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPL--TNITAALHSPLTLLCEAMGI 2379
Query: 1893 PTPTLEWTGGPGGQLPAKAQI---HGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLH 1949
P P + W G P + G +L++ + D Y C A + AG+ AR
Sbjct: 2380 PPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE--ARRNFS 2437
Query: 1950 VHGGGGPRVQVSP--ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPP-QARSERTD 2006
V P ++ E +V G+T L C G P +TW K+G L A D
Sbjct: 2438 VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPD 2497
Query: 2007 IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQ 2066
L + + AG Y C+A + G Q+ VL A +VT
Sbjct: 2498 GVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 2557
Query: 2067 TLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV------HGSRLRLPQVSPADSGEYVCRVE 2120
+ L C +TW + G + HG L++ D+G+Y C V
Sbjct: 2558 PISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVT 2615
Query: 2121 NGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPI-RIEPSSSHVAEGQTLDLNCVVPGQA 2179
N G + V VL P P+ + TL L C
Sbjct: 2616 NELGEAVKNYHVEVL--------IPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVP 2667
Query: 2180 HAQVTWHKRGGSLPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
+ W+K G + + G LL++ +DSG Y+C +G + V I
Sbjct: 2668 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 2727
Query: 2236 EASVIPGPIPPV---------------RIESSSSTVAEGQTLD------LSCVVAGQAHA 2274
+ +PP+ R E + V E + + L C
Sbjct: 2728 Q-------VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPP 2780
Query: 2275 QVTWYKRGGSLPARHQVR----GSRLYIFQASPADAGQYVCRASN--GMEASITVTVTGT 2328
+TWY+ L A +V G L I +AG+Y C+ASN G + + T
Sbjct: 2781 DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT 2840
Query: 2329 QGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG----GSLPVR 2384
L + + + SS T+ L C G ++W + G S ++
Sbjct: 2841 PPVILGDTEELVEEVTVNASS-------TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQ 2893
Query: 2385 HQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESS 2444
G +L++ A AD+ Y+C + E + ++ + L + I +S
Sbjct: 2894 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNS 2953
Query: 2445 SSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL---------PARHQVHGSRLRLLQVTP 2495
S + L C V + +VTW+K +L P H + R RL
Sbjct: 2954 S--------VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL----- 3000
Query: 2496 ADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNC 2555
+DSG Y C + ++G + LV + + + Q P + + G L+C
Sbjct: 3001 SDSGMYTCEALNAAGRDQK--LVQLSVLVPPAFRQAPRGP----QDAVLVRVGDKAVLSC 3054
Query: 2556 LVASQAPHTITWYKRGGSL--PSRHQIV--GSRLRIPQVTPADSGEYVCHVSNGAGSRET 2611
+ T+TWYK G L R Q + G RL I + +D G Y C VSN AG
Sbjct: 3055 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 3114
Query: 2612 SLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP 2671
+ +T+Q VP + E+ S V G L L C V+ P +TW K +
Sbjct: 3115 TFTLTVQ------VPPTFENPKTETVSQ--VAGSPLVLTCDVSGVPAPTVTWLKDRMPVE 3166
Query: 2672 SRHQ----THGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSM 2727
S + G L+L ++ A +G Y C A N V++V +
Sbjct: 3167 SSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAP---------- 3216
Query: 2728 PIRIESSS----SHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS------HHQTRGSR 2777
RI SS HV EG+ + L+C GQ V W K G L G
Sbjct: 3217 --RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGS 3274
Query: 2778 LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSR 2837
L L + +D+G Y C +G E + L T+ + A G +
Sbjct: 3275 LVLKGLRASDAGAYTCVAHNPAG--EDARLHTVNVLVPPTIKQGADGSGTLVS------- 3325
Query: 2838 VAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA--RHQVHGP--LLRLNQVSPADSGEYSC 2893
G+ + + C V G V+W K G LP R +HG LR+++V AD+G ++C
Sbjct: 3326 -RPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 3384
Query: 2894 QVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAH 2953
+G + + + ++ P + +P+ + + V G ++L C G
Sbjct: 3385 VAASPAGVADRNFTLQVQ--------VPPVLEPVEFQ-NDVVVVRGSLVELPCEARGVPL 3435
Query: 2954 AQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGP-EQEASFTVTVPPS 3012
V+W K G L ++ G L+L V DSG Y C A S G + TV PP
Sbjct: 3436 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPH 3495
Query: 3013 EGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN 3072
S + P ++ G C P ++ W Q L + N
Sbjct: 3496 IEDSGQ---------PTELSLTPGAPMELLCDAQGTPQP-NITWHKDGQAL---TRLENN 3542
Query: 3073 GSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKA--- 3129
++ R + G Y C+A + G + + V PP + V P GP +V VG A
Sbjct: 3543 SRATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFV-VGLAPGQ 3598
Query: 3130 VTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQN 3189
+ LEC EP W R E + LQ+ + +D+G Y C A+N
Sbjct: 3599 LVLECSVEAEPAPKITWHRDGIVLQ--EDAHTQFPERGRFLQLQALSTADSGDYSCTARN 3656
Query: 3190 ALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLR 3249
A G+ V + T P +++ + V TA L C A G PAP + W K R
Sbjct: 3657 AAGSTSVAFRVEIHT------VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR 3710
Query: 3250 SPL----PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP 3305
PL P L +L I V QD+G Y+C A++ AG L V PP P
Sbjct: 3711 VPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSP 3770
Query: 3306 EHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATAR------NELLHFERAAPED 3359
+ ++ A L C A G+P W + G L R + L P+D
Sbjct: 3771 SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQD 3830
Query: 3360 SGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF 3419
S ++ C V+N+VG A Q+ V PP T+ T ++ A V
Sbjct: 3831 SAQFECVVSNEVGEAHRLYQVTVHVPP--------------TIADDQTDFTVTMMAPVVL 3876
Query: 3420 HCAVPSDRGTQLRWFKEGGQLPP---GHSVQ-DGVLRIQNLDQSCQGTYICQAHGPWGKA 3475
C + W K G QL G+ V G L I G Y C A G A
Sbjct: 3877 TCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVA 3936
Query: 3476 QASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI-- 3533
L +QA P ++ SV V V C A G P+P +TW K G ++ G+
Sbjct: 3937 HKHVFLTVQASP--VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST 3994
Query: 3534 -VQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI--SMPQEVRVPAGS 3590
V GG +RIAH DAG Y C A N+AG+ L+VQ P I +P ++ GS
Sbjct: 3995 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLP-DLSTTEGS 4053
Query: 3591 AAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPS-------VRPQDAGTYVCTA 3643
A PC A G P P+I+W K DG P S E + PS + QDAGTY CTA
Sbjct: 4054 HAFLPCKARGSPEPNITWDK-DGQ--PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTA 4110
Query: 3644 TNRQGKVKAFAHLQVPERVVPYFTQTP 3670
N G+ + HL + V+P FT P
Sbjct: 4111 ENAVGRARRRVHLTI--LVLPVFTTLP 4135
Score = 481 bits (1237), Expect = e-135
Identities = 571/2186 (26%), Positives = 833/2186 (38%), Gaps = 334/2186 (15%)
Query: 1649 YCEQCGPGYVGNP--SVQGGQCLPETNQAPLVVEVHPARSIVPQ--GGSHS---LRCQVS 1701
Y + G + GNP V G APLV S+ P+ G H + C V
Sbjct: 399 YLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLV-------SMAPRIHGYLHQPLLVSCSVH 451
Query: 1702 GSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAEL 1761
+ P R + R Q S ++ G Y CT + + ++A++
Sbjct: 452 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 511
Query: 1762 LVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN---------G 1812
+VT+ P + + + +V PG C ++P Y L W R
Sbjct: 512 VVTDPPPQLVPAP-----NVTVSPGETAVLSCRVLGEAP-YNLTWVRDWRVLPASTGRVA 565
Query: 1813 KLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHP 1872
+L +++ +GI+ +D G Y C SN + + + L V+ AP VSIH
Sbjct: 566 QLADLSLEISGIIP------TDGGRYQCVASNANGVTRASVWLLVR-----EAPQVSIHT 614
Query: 1873 PQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH---GGILRLPAVEPTDQA 1929
G + CSA+G PTP + W+ L ++IH G L + V P D
Sbjct: 615 SSQHFSQGVEVKVSCSASGYPTPHISWSR-ESQALQEDSRIHVDAQGTLIIQGVAPEDAG 673
Query: 1930 QYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITW 1989
Y C+A + G L+ P V V G L C A+GVP + W
Sbjct: 674 NYSCQATNEVGTDQETVTLYYTDP--PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW 731
Query: 1990 RKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDAS 2049
+ G L E + L IPA DAG Y C A + G A A IQ+ V A +
Sbjct: 732 YR--GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLT 789
Query: 2050 PPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV---HGSRLRLPQ 2106
P + +V G++ L C G VTW RRG P ++ GSR R P
Sbjct: 790 ELPRDV-----TVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPD 843
Query: 2107 --------VSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP 2158
V+P D YVC N G +A + V +G + + S +R
Sbjct: 844 SGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV-----TGHAPPQIASSAPTVR--- 895
Query: 2159 SSSHVAEGQTLDLNCVV-PGQAHAQVTWHKRGGSLP--ARHQTHGS-LLRLHQVTPADSG 2214
V EGQ + L C+V G+ + W K G LP +RH L L + +G
Sbjct: 896 ----VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAG 951
Query: 2215 EYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHA 2274
Y C T+G V + ++ +P I P ++ EG L CV +G
Sbjct: 952 RYSCVATNTAGSQHRDVELVVQ---VPPRIHPTATHHITN---EGVPASLPCVASGVPAP 1005
Query: 2275 QVTWYKRGGSLPAR----HQVRGSRLYIFQASPADAGQYVCRASNGME------------ 2318
+TW K +L +R + + L I Q S DAG YVC A+N +
Sbjct: 1006 TITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNR 1065
Query: 2319 ---------------------ASITVTVTGTQGANLAYPAGSTQ---------PIRIEPS 2348
A + V +G + PAGS P +++P
Sbjct: 1066 LALSKYVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPG 1125
Query: 2349 SS--QVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVR---HQTHGSLLRLYQASPADSG 2403
+V G+ LDLNCV G Q++W K G L R H + +R +D+G
Sbjct: 1126 PRVLKVLVGEALDLNCVAEGNPEPQLSWSKDGVVLQGRGPQGSVHFAAIR-----TSDAG 1180
Query: 2404 EYVCRVLGSS-VPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2462
Y C S+ V L +EP P G T S + G+ L C G
Sbjct: 1181 RYRCEASNSAGVDAWEVELRVLEP----PHWGADET----SGLLERVAGENASLPCPARG 1232
Query: 2463 QAHAQVTWHKRGGSLPARHQ-----VHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVL 2517
QVTW K S P Q + L L V+PADSG+Y C+ G+
Sbjct: 1233 TPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAK 1292
Query: 2518 VTIQQRLSGSHSQGVAYPVRIESSSASLAN--GHTLDLNCLVASQAPHTITWYK------ 2569
+ + V +R + A+++ G +L L C I W K
Sbjct: 1293 LVVY----------VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVG 1342
Query: 2570 -----------RGGSLPSRHQIV--GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVT 2616
G H+++ G L P++ DSG Y C N AG+ +
Sbjct: 1343 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDF--- 1399
Query: 2617 IQGSGSSHVPSVSPPIRIESSSPTVV---EGQTLDLNCVVARQPQAIITWYK-RGGSLPS 2672
H+ ++PP + + + V G ++L C + P + W K R LP
Sbjct: 1400 -------HLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPG 1452
Query: 2673 ----RHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMP 2728
+ Q G LR+ V D G Y C A + + V P+ GS+
Sbjct: 1453 GPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH---APPTIWGSN-- 1507
Query: 2729 IRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ---TRGSR-LRLHHVS 2784
E+ V E + L C G +TW K G LP+ + TRG R L+L
Sbjct: 1508 ---ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQ 1564
Query: 2785 PADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTL 2844
+D+G Y C+ + G E + + + + + GG P + + G+ +
Sbjct: 1565 SSDAGVYTCKASNAVGAAEKATRLDVYVPPT----IEGAGGRPYV------VKAVAGRPV 1614
Query: 2845 DLKCVVPGQAHAQVTWHKRGGNLP------ARHQVHGPLLRLNQVSPADSGEYSCQVTGS 2898
L+CV G ++WH G LP +R + G +LRL A SG YSC +
Sbjct: 1615 ALECVARGHPSPTLSWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSP 1672
Query: 2899 SG--TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQV 2956
+G L+ SV V + P + A GL Q I GQ L+L C G +
Sbjct: 1673 AGEAVLQYSVEVQVPPQL---LVAEGLGQVTTI--------VGQPLELPCQASGSPVPTI 1721
Query: 2957 TWYKRGGSLPARH------QTHGSQLRLHLVSPADSGEYVCRA---ASGPGPEQEASF-- 3005
W + G PA + G+ L + V SG + C+A A G E E S
Sbjct: 1722 QWLQNG--RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVHG 1779
Query: 3006 -----TVTVPPSE---GSSYRLRSPVISIDPPSSTVQQGQDASFK-CLIHDGAAPISLEW 3056
+ VP + G + P + DPP V +G A K L+ +P SL
Sbjct: 1780 EWAPGVLEVPIGQYHWGXEHHSSFPA-ACDPP---VHRGWGAHPKPPLVEGWCSPGSLWG 1835
Query: 3057 KTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV 3116
+ + + P I V R + G Y C A+N G ++ V L V PP +
Sbjct: 1836 EPTGIPV---AYSLPPPLQIEKVDLR--DEGIYTCAATNLAGESKREVALKVLVPPNIE- 1889
Query: 3117 LPEGPV--WVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISS 3174
GPV V +VTLEC+++G P W + P +D VL+I
Sbjct: 1890 --PGPVNKAVLENASVTLECLASGVPPPDVSWFK-GHQPVSSWMGVTVSVDGR-VLRIEQ 1945
Query: 3175 AKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCS 3234
A+ SDAG+Y C+A N G+ + + + V+ P + V L C+
Sbjct: 1946 AQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG-----PVLVNTPVRLTCN 2000
Query: 3235 ATGSPAPTIHWSKLRSPLP------WQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAE 3288
ATG+P+PT+ W K +P+ Q G L + DSG+Y C A S G
Sbjct: 2001 ATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDR 2060
Query: 3289 ATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL---PG-RAT 3344
++L V PP + SV A E+V L+C +H PP W + G L PG +
Sbjct: 2061 QDVVLQVHMPPSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLS 2120
Query: 3345 ARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQV 3404
A LL +RA D+G Y C N+ G +E L V P P + T+ V
Sbjct: 2121 ADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAP------VFPLRESHTLTV 2174
Query: 3405 TPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP-PGHSVQ--DGVLRIQNLDQ--- 3458
G C ++ W K+G LP G +Q V R+ L Q
Sbjct: 2175 RE-------GHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQL 2227
Query: 3459 SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAV-EFECLALGDPK 3517
+ +GTY C+ G + QL + P + Q VV V EC A G P
Sbjct: 2228 AQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKPP 2287
Query: 3518 PQVTWSK----VGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ 3573
P VTW + VG L + G + + + A G+Y C A N AG + L V
Sbjct: 2288 PTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVL 2347
Query: 3574 ALPQ----ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPP--DSRLENN--M 3625
P+ + + S C A G P P I W + + + P D+ L M
Sbjct: 2348 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWM 2407
Query: 3626 LMLPSVRPQDAGTYVCTATNRQGKVK 3651
L + + QD+G Y C A+N G+ +
Sbjct: 2408 LKMTQTQEQDSGLYSCLASNEAGEAR 2433
Score = 474 bits (1220), Expect = e-133
Identities = 537/2043 (26%), Positives = 788/2043 (38%), Gaps = 243/2043 (11%)
Query: 1731 LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPS-KPITVTVEEQRSQSVRPGADV 1789
L V D G+Y C NL + L V P+ +P V +++V A V
Sbjct: 1850 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPV------NKAVLENASV 1903
Query: 1790 TFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN---GILTIRNVQLSDAGTYVCTGSNMF 1846
T C A P + W + H + + +L I QLSDAG+Y C SN+
Sbjct: 1904 TLECLASGVPPP-DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 1962
Query: 1847 AMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTG----- 1901
+ L V ++ P S+ P L P +L C+ATG+P+PTL W
Sbjct: 1963 GSTELRYGLRVNVPPRITLP-PSLPGPVLVNTPVRLT---CNATGAPSPTLMWLKDGNPV 2018
Query: 1902 GPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVS 1961
P G + G +L L + +D +Y C A S+ G+ VL VH P +
Sbjct: 2019 SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVH--MPPSILGE 2076
Query: 1962 PERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE-RTDIATLLIPAITTADA 2020
V A +V L C++ +P ++W K+G L P+ D A L + DA
Sbjct: 2077 ELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDA 2136
Query: 2021 GFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080
G Y C A + AG ++ + V A P ES + +V EG L+C G
Sbjct: 2137 GHYTCEALNQAGHSEKHYNLNVWVA----PVFPLRESHTLTVREGHPTSLSCECRGVPFP 2192
Query: 2081 QVTWYRRGGSLP------PHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
+++W + G LP H G L L Q A G Y C N G + + V
Sbjct: 2193 KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 2252
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKR----GG 2190
H P + G P P+ V + L C G+ VTW + G
Sbjct: 2253 ----HVPPQ---IAGPREP----PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGA 2301
Query: 2191 SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSG----PLEASVLVTIEASVIPGPIPP 2246
L + Q G L + + A +G Y C +G E SVLV E + G + P
Sbjct: 2302 ELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE---LIGDLDP 2358
Query: 2247 VRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH------QVRGSRLYIFQ 2300
+ ++ T A L L C G + W++ G P G L + Q
Sbjct: 2359 L----TNITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLAGGWMLKMTQ 2412
Query: 2301 ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSS--QVAEGQTL 2358
D+G Y C ASN G N + I E +V +GQT
Sbjct: 2413 TQEQDSGLYSCLASN---------EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 2463
Query: 2359 DLNCVVPGQSHAQVTWHKRGGSLPVRHQTH-----GSLLRLYQASPADSGEYVC---RVL 2410
L C V G ++TW K G L R H G LL++ QA+ + +G Y C +
Sbjct: 2464 HLMCNVTGHPQPKLTWFKDGRPL-ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAV 2522
Query: 2411 GSSVP-LEASVLVTIEPAGSVPALGVTPTVRIESSSSQ---VAEGQTLDLNCLVAGQAHA 2466
G + SVL+ G E S+ + V + L C
Sbjct: 2523 GEKTKHFQLSVLLAPTILGGA-----------EDSADEEVTVTVNNPISLICEALAFPSP 2571
Query: 2467 QVTWHKRGGSLPARHQV------HGSRLRLLQVTPADSGEYVCRVVGSSG--TQEASVLV 2518
+TW K G A + HG L++L D+G+Y C V G + V V
Sbjct: 2572 NITWMKDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 2629
Query: 2519 TIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL--PS 2576
I +S G +++ S TL L C + P TI WYK G + S
Sbjct: 2630 LIPPSISKDDPLGEVGVKEVKTKVNS-----TLTLECESWAVPPPTIRWYKDGQPVTPSS 2684
Query: 2577 RHQIVGSRLRIPQVTP---ADSGEYVCHVSNGAGSRETSLIVTIQGSGS-SHVPSVSPPI 2632
R Q++G R+ Q+ P +DSG Y+C +N AG + V IQ V S
Sbjct: 2685 RLQVLGEG-RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAF 2743
Query: 2633 RIESSSP----------TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH----G 2678
I S +VE L C P +TWY+ L + + G
Sbjct: 2744 EILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGG 2803
Query: 2679 SHLRLHQMSVADSGEYVCRANNNI--DALEASIVISVSPSAGSPSAPGSSMPIRIESSSS 2736
L++ + ++G Y C+A+N + D L +++ ++P P G + + E +
Sbjct: 2804 RVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLV-LTP----PVILGDTEELVEEVT-- 2856
Query: 2737 HVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR------GSRLRLHHVSPADSGE 2790
V T+ L C G ++W + G LP R G L++ AD+
Sbjct: 2857 -VNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVADAAS 2913
Query: 2791 YVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVV 2850
Y+C +G A L T+ V P + +E ++ + ++ L C V
Sbjct: 2914 YMCVAENQAG--SAEKLFTL--------RVQVPPRIAGLDLEQVTAIL--NSSVSLPCDV 2961
Query: 2851 PGQAHAQVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGTLEASV 2906
+ +VTW+K L +V L+L + +DSG Y+C+ ++G + V
Sbjct: 2962 HAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLV 3021
Query: 2907 LVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLP 2966
+++ + P Q + V G L+C VTWYK G L
Sbjct: 3022 QLSV-------LVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLV 3074
Query: 2967 ARHQTH----GSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSP 3022
+T G +L + +D G Y C+ ++ G E +FT+TV + P
Sbjct: 3075 LAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTV----------QVP 3123
Query: 3023 VISIDPPSSTVQQ--GQDASFKCLIHDGAAPISLEWKTRNQELEDNVH-ISPNGSIITIV 3079
+P + TV Q G C + AP K R VH + G + +
Sbjct: 3124 PTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLS 3183
Query: 3080 GTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV-SVLPEGPVWVKVGKAVTLECVSAG 3138
+P+ GTY CVA N A+ ++V P + S V G+ V L+C + G
Sbjct: 3184 RLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADG 3243
Query: 3139 EPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQV 3198
+P W + S + L + + SDAG Y C+A N G +
Sbjct: 3244 QPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLH 3303
Query: 3199 EVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRL 3258
V V + P Q L G T+ C GSP + W K PLP R
Sbjct: 3304 TVNV---LVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRT 3360
Query: 3259 ----EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTV--PEHASVQA 3312
G TL I +V D+G + C A SPAG A+ L V+ PP V V
Sbjct: 3361 LLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVR 3420
Query: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVG 3372
G V+L C A G P W + G L ++ + L E DSG Y C ++ G
Sbjct: 3421 GSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAG 3480
Query: 3373 SAEAFAQLLVQGPPGSLPATSIPAGSTPT-VQVTPQLETKSIGASVEFHCAVPSDRGTQL 3431
A QL V PP I PT + +TP GA +E C +
Sbjct: 3481 EARRHFQLTVMEPP------HIEDSGQPTELSLTP-------GAPMELLCDAQGTPQPNI 3527
Query: 3432 RWFKEGGQLP--PGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSV 3489
W K+G L +S VLR+++ G Y C A P G + S ++ +QA P++
Sbjct: 3528 TWHKDGQALTRLENNSRATRVLRVRD-----AGLYTCLAESPAGAIEKSFRVRVQAPPNI 3582
Query: 3490 LINIRTSVQTVVVGHA---VEFECLALGDPKPQVTWSKVGGHLRPG----IVQSGGVVRI 3542
+ VVG A + EC +P P++TW + G L+ + G +++
Sbjct: 3583 ---VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQL 3639
Query: 3543 AHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI-SMPQEVRVPAGSAAVFPCIASGY 3601
+ AD+G Y CTA NAAG+T + + +P I S P V V A+ PC A G
Sbjct: 3640 QALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGV 3699
Query: 3602 PTPDISWSK----LDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQ 3657
P P +SW K LD P L L + V QDAG Y+C A+N G + L+
Sbjct: 3700 PAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLR 3759
Query: 3658 VPE 3660
V E
Sbjct: 3760 VLE 3762
Score = 466 bits (1198), Expect = e-130
Identities = 524/2085 (25%), Positives = 801/2085 (38%), Gaps = 236/2085 (11%)
Query: 1676 PLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPS--GTQQRHQGSELHF 1733
P +E P V + S +L C SG PP W + +PV S G G L
Sbjct: 1885 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGH-QPVSSWMGVTVSVDGRVLRI 1943
Query: 1734 PSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFIC 1793
Q SDAG Y C N+ S R L V P +T+ V V C
Sbjct: 1944 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPP----RITLPPSLPGPVLVNTPVRLTC 1999
Query: 1794 TAKSKSPAYTLVWTRLHNGKLPT-----RAMDFNGILTIRNVQLSDAGTYVCTGSNMFAM 1848
A + +P+ TL+W + N P + +LT+ + + SD+G Y C +
Sbjct: 2000 NA-TGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGE 2058
Query: 1849 DQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLP 1908
D+ L V ++ +++ +V + C + P P L W G L
Sbjct: 2059 DRQDVVLQVHMPPSILGEELNV-----SVVANESVALECQSHAMPPPVLSW-WKDGRPLE 2112
Query: 1909 AKAQIH----GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPER 1964
+ +H +L++ + D Y C A + AG L+V ++ S
Sbjct: 2113 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 2172
Query: 1965 TQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT---LLIPAITTADAG 2021
T V G L C GVP I+WRK+G LP + + A L + A G
Sbjct: 2173 T-VREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 2231
Query: 2022 FYLCVATSPAGTAQARIQVVV-LSASDASP--PPVKIESSSPSVTEGQTLDLNCVVAGSA 2078
Y C ++ G + +Q+ V + A P PP ++ SV + L C G
Sbjct: 2232 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV-----SVVQDGVATLECNATGKP 2286
Query: 2079 HAQVTWYRR----GGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
VTW R G L Q G L + + A +G Y C EN +G E +SV
Sbjct: 2287 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV 2346
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194
L P+ T + L L C G + W + +
Sbjct: 2347 LVPPELIGDLDPLTNITAALH-----------SPLTLLCEAMGIPPPAIRWFRGEEPVSP 2395
Query: 2195 RHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIE 2250
T+ G +L++ Q DSG Y C +G + V + ++P I +E
Sbjct: 2396 GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV---LVPPSIENEDLE 2452
Query: 2251 SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL---PARH-QVRGSRLYIFQASPADA 2306
V +GQT L C V G ++TW+K G L A H G L + QA+ + A
Sbjct: 2453 EVIK-VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSA 2511
Query: 2307 GQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQ---VAEGQTLDLNCV 2363
G Y C A+N + T+ L+ T E S+ + V + L C
Sbjct: 2512 GHYSCIAANAVGEK-------TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICE 2564
Query: 2364 VPGQSHAQVTWHKRGG------SLPVRHQTHGSLLRLYQASPADSGEYVCRV---LGSSV 2414
+TW K G ++ + THG L++ A D+G+Y C V LG +V
Sbjct: 2565 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVTNELGEAV 2622
Query: 2415 PLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG 2474
V V I P+ S P + + TL L C + W+K G
Sbjct: 2623 K-NYHVEVLIPPSISKD----DPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDG 2677
Query: 2475 GSL--PARHQVHGSRLRLLQVTP---ADSGEYVCRVVGSSG--TQEASVLVTIQQRLSGS 2527
+ +R QV G RLLQ+ P +DSG Y+C +G Q+ +VL+ +
Sbjct: 2678 QPVTPSSRLQVLGEG-RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKV 2736
Query: 2528 HSQGVAYPVRIESSSA--------SLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQ 2579
A+ + A + + L C + P +TWY+ L + +
Sbjct: 2737 GDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE 2796
Query: 2580 IV----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIE 2635
+ G L+IP V ++G Y C SN G + + ++PP+ +
Sbjct: 2797 VSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLV----------LTPPVILG 2846
Query: 2636 SSSPTVVE-----GQTLDLNCVVARQPQAIITWYKRG--GSLPSRHQT--HGSHLRLHQM 2686
+ V E T+ L C P I+W + G S R Q G L++
Sbjct: 2847 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTA 2906
Query: 2687 SVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDL 2746
VAD+ Y+C A N + E + V P + +E ++ + ++ L
Sbjct: 2907 EVADAASYMCVAENQAGSAEKLFTLRV-------QVPPRIAGLDLEQVTAIL--NSSVSL 2957
Query: 2747 NCVVPGQAHAQVTWHKRGGS---------LPSHHQTRGSRLRLHHVSPADSGEYVCRVMG 2797
C V + +VTW+K + LP H + R RL +DSG Y C +
Sbjct: 2958 PCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL-----SDSGMYTCEALN 3012
Query: 2798 SSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQ 2857
++G + V +++ + P A +R+ G L C
Sbjct: 3013 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV---------GDKAVLSCETDALPEPT 3063
Query: 2858 VTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPS 2913
VTW+K G L + G L + + +D G YSC+V+ +G + +T++
Sbjct: 3064 VTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ-- 3121
Query: 2914 SPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ--- 2970
+P P P + + G L L C V G VTW K +P
Sbjct: 3122 ----VP-PTFENP---KTETVSQVAGSPLVLTCDVSGVPAPTVTWLK--DRMPVESSAVH 3171
Query: 2971 ---THGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISID 3027
+ G +L+L + PA +G Y C A E F V V + R+RS ++ +
Sbjct: 3172 GVVSRGGRLQLSRLQPAQAGTYTC-VAENTQAEARKDFVVAVLVAP----RIRSSGVARE 3226
Query: 3028 PPSSTVQQGQDASFKCLIHDGAAPISLEW----KTRNQELEDNVHISPNGSIITIVGTRP 3083
V +GQ+ C DG P + W Q++ ++ +G + + G R
Sbjct: 3227 ---HHVLEGQEVRLDCEA-DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA 3282
Query: 3084 SNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE--GPVWVKVGKAVTLECVSAGEPR 3141
S+ G Y CVA N G + ++V PPT+ + G + + G+ VT+ C G P
Sbjct: 3283 SDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP 3342
Query: 3142 SSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVI 3201
W + P L QRT L S L+IS + +DAG + C+A + G A + +
Sbjct: 3343 IHVSWLK-DGLPLPLSQRTL-LHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQ 3400
Query: 3202 VDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGD 3261
V P + + ++ V G L C A G P P + W K PL Q +G
Sbjct: 3401 V----QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGP 3456
Query: 3262 TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYA--TTVPEHASVQAGETVQLQ 3319
+L + V DSG Y C A S AG A L V PP+ + P S+ G ++L
Sbjct: 3457 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELL 3516
Query: 3320 CLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQ 3379
C A GTP W + G +L N D+G Y C + G+ E +
Sbjct: 3517 CDAQGTPQPNITWHKDGQAL---TRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFR 3573
Query: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
+ VQ PP + P G V + P + C+V ++ ++ W ++G
Sbjct: 3574 VRVQAPPNIVG----PRGPRFVVGLAP--------GQLVLECSVEAEPAPKITWHRDGIV 3621
Query: 3440 LPPGHSVQ----DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRT 3495
L Q L++Q L + G Y C A G + ++ I +P+ I
Sbjct: 3622 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPT--IRSGP 3679
Query: 3496 SVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI----VQSGGVVRIAHVELADAG 3551
V V C A G P P V+W K L P + G +RI V DAG
Sbjct: 3680 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 3739
Query: 3552 QYRCTATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVFPCIASGYPTPDISW-- 3608
Y C A+N+AG+ + L V P I+ P + + A + A+ PC ASG P P + W
Sbjct: 3740 HYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK 3799
Query: 3609 --SKLDGSLPPDS--RLENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
KLD L + L +N L+L + PQD+ + C +N G+
Sbjct: 3800 DGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE 3844
Score = 457 bits (1177), Expect = e-128
Identities = 529/2000 (26%), Positives = 767/2000 (38%), Gaps = 294/2000 (14%)
Query: 1822 NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQ 1881
N I ++ GTY CT + + A + V P + P +TV PG+
Sbjct: 478 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT-----DPPPQLVPAPNVTVSPGE 532
Query: 1882 LAEFRCSATGSPTPTLEWTGGPGGQLPAK----AQIHGGILRLPAVEPTDQAQYLCRAHS 1937
A C G L W LPA AQ+ L + + PTD +Y C A +
Sbjct: 533 TAVLSCRVLGEAPYNLTWVRD-WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 591
Query: 1938 SAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLP 1997
+ G V RA + + P+V + G V++ C A+G P+ I+W +E +L
Sbjct: 592 ANG--VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 649
Query: 1998 PQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIES 2057
+R TL+I + DAG Y C AT+ GT Q + V L +D PP V +
Sbjct: 650 EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ---ETVTLYYTD--PPSVSAVN 704
Query: 2058 SSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGS--LPPHTQVHGSRLRLPQVSPADSGEY 2115
+ V G+ L C +G +V WYR G L P G +LR+P D+G Y
Sbjct: 705 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG-KLRIPAAQERDAGTY 763
Query: 2116 VCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVV 2175
CR N G A I ++V H P T +P R + +E G++ L C
Sbjct: 764 TCRAVNELGDASAEIQLAVGH----APQLTELP---RDVTVE-------LGRSALLACRA 809
Query: 2176 PGQAHAQVTWHKRGGSLP-----------ARHQTHGSLLRLHQVTPADSGEYVCHVVGTS 2224
G+ VTW +RG P Q +L V P D YVC
Sbjct: 810 TGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 868
Query: 2225 GPLEASVLVTIEASVIPGPIPPVRIESSSST--VAEGQTLDLSCVV-AGQAHAQVTWYKR 2281
G ++A + ++ G PP +I SS+ T V EGQ + L C+V AG+ + W K
Sbjct: 869 GKVQAEARL-----IVTGHAPP-QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 922
Query: 2282 GGSLP--ARHQVRG-SRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAG 2338
G LP +RH +R L++ +A AG+Y C A+N G+Q ++
Sbjct: 923 GRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN---------TAGSQHRDVELVV- 972
Query: 2339 STQPIRIEPSSSQ--VAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRH-----QTHGSL 2391
P RI P+++ EG L CV G +TW K +L R G+L
Sbjct: 973 -QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTL 1031
Query: 2392 LRLYQASPADSGEYVCRVLG----SSVPLEASV--------------------------- 2420
L + Q S D+G YVC SS + SV
Sbjct: 1032 L-IAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLRLAQVQ 1090
Query: 2421 --------LVTIEPAGS-----VPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQ 2467
PAGS V + V P V+ +V G+ LDLNC+ G Q
Sbjct: 1091 VGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEALDLNCVAEGNPEPQ 1150
Query: 2468 VTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGS 2527
++W K G L R GS + + +D+G Y C S+G V + + +
Sbjct: 1151 LSWSKDGVVLQGRGP-QGS-VHFAAIRTSDAGRYRCEASNSAGVDAWEVELRVLEPPHWG 1208
Query: 2528 HSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQ-----IVG 2582
+ R+ +ASL C +TW K S P Q +
Sbjct: 1209 ADETSGLLERVAGENASLP--------CPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEE 1260
Query: 2583 SRLRIPQVTPADSGEYVCHVSN--GAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT 2640
L + V+PADSG+Y C +N G+ SR L+V +VP P IR +
Sbjct: 1261 GSLFLASVSPADSGDYECQATNEVGSTSRRAKLVV--------YVP---PSIREDGRKAN 1309
Query: 2641 V--VEGQTLDLNCVVARQPQAIITWYK-----------------RGGSLPSRHQ--THGS 2679
V + GQ+L L C P I W K G H+ G
Sbjct: 1310 VSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQ 1369
Query: 2680 HLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA 2739
L ++ DSG Y CRA N + + V PS G+ + +
Sbjct: 1370 SLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLV---LTPPSVLGAGAAQEVLGLA---- 1422
Query: 2740 EGETLDLNCVVPGQAHAQVTWHK-RGGSLPS--HHQTR--GSRLRLHHVSPADSGEYVCR 2794
G ++L C G QV W K R LP H Q + G LR+ D G Y C
Sbjct: 1423 -GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCV 1481
Query: 2795 VMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQA 2854
+G + + A P G+ E V E + L C G
Sbjct: 1482 AFSPAGQQARDFQLRVHAP-------PTIWGSN----ETGEVAVMEDHLVQLLCEARGVP 1530
Query: 2855 HAQVTWHKRGGNLPARHQV----HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTI 2910
+TW K G LP +V G L+L + +D+G Y+C+ + + G E + +
Sbjct: 1531 TPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKA--TRL 1588
Query: 2911 EPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRG----GSLP 2966
+ P I G +P ++A G+ + L CV G ++W+ G S
Sbjct: 1589 DVYVPPTIEGAG-GRPYVVKA-----VAGRPVALECVARGHPSPTLSWHHEGLPVAESNE 1642
Query: 2967 ARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE-QEASFTVTVPPSEGSSYRLRSPVIS 3025
+R +T GS LRL A SG Y C A+S G + S V VPP +++
Sbjct: 1643 SRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPP---------QLLVA 1693
Query: 3026 IDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELED--NVHISPNGSIITIVGTRP 3083
T GQ C P +++W + E+ V ++ G+ + I
Sbjct: 1694 EGLGQVTTIVGQPLELPCQASGSPVP-TIQWLQNGRPAEELAGVQVASQGTTLHIDHVEL 1752
Query: 3084 SNHGTYRCVASNAYGVAQSVVNLSVHG--PPTVSVLPEGPV-WVKVGKAVTLECVSAGEP 3140
+ G + C A+N G A + V +SVHG P V +P G W G +A +P
Sbjct: 1753 DHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHW---GXEHHSSFPAACDP 1809
Query: 3141 RSSARWTRISS--------TPAKLEQRTYGLMDSHAV---LQISSAKPSDAGTYVCLAQN 3189
W +P L G+ ++++ LQI D G Y C A N
Sbjct: 1810 PVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATN 1869
Query: 3190 ALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLR 3249
G ++++V + V + P P ++ V + TL C A+G P P + W K
Sbjct: 1870 LAGESKREVALKV----LVP--PNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGH 1923
Query: 3250 SPL-PWQH---RLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP 3305
P+ W ++G L I + D+G Y C A++ AG E L V PP T P
Sbjct: 1924 QPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPP 1983
Query: 3306 E-HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-----PG-RATARNELLHFERAAPE 3358
V V+L C A G P T W + G+ + PG + +L A
Sbjct: 1984 SLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARAS 2043
Query: 3359 DSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVE 3418
DSGRY C + VG L V PP L G V V + +S+ +
Sbjct: 2044 DSGRYSCVAVSAVGEDRQDVVLQVHMPPSIL-------GEELNVSV---VANESVALECQ 2093
Query: 3419 FHCAVPSDRGTQLRWFKEGGQLPPGH----SVQDGVLRIQNLDQSCQGTYICQAHGPWGK 3474
H P L W+K+G L P S +L++ D G Y C+A G
Sbjct: 2094 SHAMPP----PVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGH 2149
Query: 3475 AQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG-- 3532
++ L + P + + TV GH C G P P+++W K G L PG
Sbjct: 2150 SEKHYNLNVWVAPVFPLR-ESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPL-PGEG 2207
Query: 3533 -----IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQE---- 3583
+ G ++ + +LA G Y C +N G + + L V PQI+ P+E
Sbjct: 2208 AGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQ 2267
Query: 3584 VRVPAGSAAVFPCIASGYPTPDISWSKLDG---SLPPDSRLENNMLMLPSVRPQDA--GT 3638
V V A C A+G P P ++W + DG +L+N L R Q A G
Sbjct: 2268 VSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAHTGR 2326
Query: 3639 YVCTATNRQGKVKAFAHLQV 3658
Y C A N G+ + L V
Sbjct: 2327 YSCVAENLAGRAERKFELSV 2346
Score = 452 bits (1163), Expect = e-126
Identities = 546/2178 (25%), Positives = 825/2178 (37%), Gaps = 282/2178 (12%)
Query: 1631 LGAGGYRCTACEPGYTGQY-CEQCGP-GYVGNPSVQGGQCLPETNQAPLVVEVHPARSIV 1688
L +G R + G +G Y C P G + V G Q P+ P V++V ++
Sbjct: 1079 LPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLVGEAL- 1137
Query: 1689 PQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTC 1748
L C G+P WS+ DG + Q R +HF +++ SDAG Y C
Sbjct: 1138 ------DLNCVAEGNPEPQLSWSK-DGVVL----QGRGPQGSVHFAAIRTSDAGRYRCEA 1186
Query: 1749 RNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVR-PGADVTFICTAKSKSPAYTLVWT 1807
N + EL V E P +E R G + + C A+ +P + W
Sbjct: 1187 SNSAGVDAWEVELRVLEPPH----WGADETSGLLERVAGENASLPCPARG-TPKPQVTWR 1241
Query: 1808 R------LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASG 1861
+ LH P A+ G L + +V +D+G Y C +N A L V
Sbjct: 1242 KGPSSEPLHG--QPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP 1299
Query: 1862 TLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW------TGGP-----------G 1904
++ ++ GQ C A G P P + W G P
Sbjct: 1300 SIRE---DGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 1356
Query: 1905 GQLPAKAQI-HGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPE 1963
GQ+ + G L P ++ D Y CRA + AG A+ H+ P V +
Sbjct: 1357 GQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAG--TAQRDFHLLVLTPPSVLGAGA 1414
Query: 1964 RTQV--HAGRTVRLYCRAAGVPSATITWRKEGGSLPPQA--RSERTDIATLLIPAITTAD 2019
+V AG V L C +GVP+ + W K+ + P + D L I D
Sbjct: 1415 AQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGD 1474
Query: 2020 AGFYLCVATSPAGTAQARIQVVVLSASDASPPPV--KIESSSPSVTEGQTLDLNCVVAGS 2077
G Y CVA SPAG Q+ V +PP + E+ +V E + L C G
Sbjct: 1475 EGRYQCVAFSPAGQQARDFQLRV-----HAPPTIWGSNETGEVAVMEDHLVQLLCEARGV 1529
Query: 2078 AHAQVTWYRRGGSLPPHTQV----HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVS 2133
+TW++ G LP T+V G +L+L + +D+G Y C+ N G E + +
Sbjct: 1530 PTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLD 1589
Query: 2134 VLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRG---- 2189
V VP + P G+ + L CV G ++WH G
Sbjct: 1590 VY-----------VPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVA 1638
Query: 2190 GSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRI 2249
S +R +T GS+LRL A SG Y C V +S EA + ++E V P + V
Sbjct: 1639 ESNESRLETDGSVLRLESPGEASSGLYSC--VASSPAGEAVLQYSVEVQVPPQLL--VAE 1694
Query: 2250 ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQASP 2303
T GQ L+L C +G + W + G PA +G+ L+I
Sbjct: 1695 GLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--RPAEELAGVQVASQGTTLHIDHVEL 1752
Query: 2304 ADAGQYVCRASN-----GMEASITVTVTGTQGANLAYPAG---------STQPIRIEPSS 2349
+G + C+A+N G E ++V G L P G S+ P +P
Sbjct: 1753 DHSGLFACQATNEAGTAGAEVEVSVHGEWAPGV-LEVPIGQYHWGXEHHSSFPAACDPPV 1811
Query: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRV 2409
+ +V G W + G +PV + L++ + D G Y C
Sbjct: 1812 HRGWGAHPKP--PLVEGWCSPGSLWGEPTG-IPVAYSLPPP-LQIEKVDLRDEGIYTCAA 1867
Query: 2410 LGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT 2469
+ + V + + V P + + V E ++ L CL +G V+
Sbjct: 1868 TNLAGESKREVALKVL---------VPPNIEPGPVNKAVLENASVTLECLASGVPPPDVS 1918
Query: 2470 WHKRGGSLPARH------QVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEA--SVLVTIQ 2521
W K G P V G LR+ Q +D+G Y C +G+ E + V +
Sbjct: 1919 WFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVP 1976
Query: 2522 QRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL-----PS 2576
R++ S + PV + + + L C T+ W K G + P
Sbjct: 1977 PRITLPPS--LPGPVLVNT---------PVRLTCNATGAPSPTLMWLKDGNPVSPAGTPG 2025
Query: 2577 RHQIVGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIE 2635
G R L + +DSG Y C + G +++ + H+P P I E
Sbjct: 2026 LQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQV------HMP---PSILGE 2076
Query: 2636 SSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSH----LRLHQMSVADS 2691
+ +VV +++ L C P +++W+K G L R H S L++ + V D+
Sbjct: 2077 ELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDA 2136
Query: 2692 GEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVP 2751
G Y C A N E ++V + P+R ES + V EG L+C
Sbjct: 2137 GHYTCEALNQAGHSEKHYNLNVWVA--------PVFPLR-ESHTLTVREGHPTSLSCECR 2187
Query: 2752 GQAHAQVTWHKRGGSLP------SHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEAS 2805
G +++W K G LP H G L L A G Y C G +S
Sbjct: 2188 GVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG--NSS 2245
Query: 2806 VLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKR-- 2863
+ +E VHVP P R P+ V + L+C G+ VTW +
Sbjct: 2246 QDLQLE------VHVPPQIAGP--REPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQ 2297
Query: 2864 --GGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAP 2921
G L + Q G L + + A +G YSC +G E E S P
Sbjct: 2298 PVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERK----FELSVLVPPELI 2353
Query: 2922 GLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH----GSQLR 2977
G P+ ++ H L L C G + W++ + T+ G L+
Sbjct: 2354 GDLDPLTNITAALH----SPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLK 2409
Query: 2978 LHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQG 3036
+ DSG Y C A++ G + S V VPPS + L + +D G
Sbjct: 2410 MTQTQEQDSGLYSCLASNEAGEARRNFSVEVLVPPSI-ENEDLEEVIKVLD--------G 2460
Query: 3037 QDASFKCLIHDGAAPISLEWKTRNQELE--DNVHISPNGSIITIVGTRPSNHGTYRCVAS 3094
Q A C + P L W + L D HISP+G ++ ++ S+ G Y C+A+
Sbjct: 2461 QTAHLMCNVTGHPQP-KLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAA 2519
Query: 3095 NAYGVAQSVVNLSVHGPPTV----SVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRIS 3150
NA G LSV PT+ + V V V ++L C + P + W +
Sbjct: 2520 NAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALAFPSPNITWMK-D 2578
Query: 3151 STPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK--QVEVIVDTGAMA 3208
P + + L +H LQI +A+ DAG Y C+ N LG A K VEV++ +++
Sbjct: 2579 GAPFEASRNIQLLPGTHG-LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPP-SIS 2636
Query: 3209 PGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRL----EGDTLI 3264
P + E+ + T TL C + P PTI W K P+ RL EG L
Sbjct: 2637 KDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQ 2696
Query: 3265 IPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATT--------------------V 3304
I DSG+Y+C AT+ AG + + ++ PP V
Sbjct: 2697 IQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGV 2756
Query: 3305 PEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG----RATARNELLHFERAAPEDS 3360
E+ + L C + PP W R L +L E++
Sbjct: 2757 TEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENA 2816
Query: 3361 GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420
GRY C+ +N+VG +LLV PP L T + + T + ++V
Sbjct: 2817 GRYSCKASNEVGEDWLHYELLVLTPPVILGDT----------EELVEEVTVNASSTVSLQ 2866
Query: 3421 CAVPSDRGTQLRWFKEGGQLPPGHSVQ---DG-VLRIQNLDQSCQGTYICQAHGPWGKAQ 3476
C + + W + G P +Q DG VL++ + + +Y+C A G A+
Sbjct: 2867 CPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAE 2926
Query: 3477 ASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG---- 3532
L +Q +P + + T ++ +V C P P+VTW K L G
Sbjct: 2927 KLFTLRVQ-VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVF 2985
Query: 3533 IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISM----PQE-VRVP 3587
++ +++ L+D+G Y C A NAAG Q V L V P PQ+ V V
Sbjct: 2986 LLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVR 3045
Query: 3588 AGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE----NNMLMLPSVRPQDAGTYVCTA 3643
G AV C P P ++W K L R + L + + D G Y C
Sbjct: 3046 VGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKV 3105
Query: 3644 TNRQGK-VKAFA-HLQVP 3659
+N G+ V+ F +QVP
Sbjct: 3106 SNVAGEAVRTFTLTVQVP 3123
Score = 436 bits (1122), Expect = e-121
Identities = 501/1875 (26%), Positives = 729/1875 (38%), Gaps = 258/1875 (13%)
Query: 1685 RSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAG 1742
R IV ++ L C + PP W RED +P+ +G + G L P V+ +AG
Sbjct: 2760 REIVENNPAY-LYCDTNAIPPPDLTWYRED-QPLSAGDEVSVLQGGRVLQIPLVRAENAG 2817
Query: 1743 VYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAY 1802
Y C N + ELLV P + T E +V + V+ C A +P
Sbjct: 2818 RYSCKASNEVGEDWLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALG-NPVP 2875
Query: 1803 TLVWTRLHNGKLP------TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLH 1856
T+ W L NG LP + ++ +L + +++DA +Y+C N + TL
Sbjct: 2876 TISW--LQNG-LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 2932
Query: 1857 VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW--------TGGPGGQLP 1908
VQ + + + Q+T C P P + W G LP
Sbjct: 2933 VQ----VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP 2988
Query: 1909 AKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQ-- 1966
+ G RL +D Y C A ++AG+ L V P + +P Q
Sbjct: 2989 GTHTLQLGRARL-----SDSGMYTCEALNAAGRDQKLVQLSVLVP--PAFRQAPRGPQDA 3041
Query: 1967 --VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT----LLIPAITTADA 2020
V G L C +P T+TW K+G P ++RT L I +D
Sbjct: 3042 VLVRVGDKAVLSCETDALPEPTVTWYKDG---QPLVLAQRTQALRGGQRLEIQEAQVSDK 3098
Query: 2021 GFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080
G Y C ++ AG A + V P ++ + S G L L C V+G
Sbjct: 3099 GLYSCKVSNVAGEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCDVSGVPAP 3154
Query: 2081 QVTWYRRGGSLPPHTQ-VHG-----SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
VTW + +P + VHG RL+L ++ PA +G Y C EN V+V
Sbjct: 3155 TVTWLK--DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAV 3212
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194
L S G R HV EGQ + L+C GQ V W K G L
Sbjct: 3213 LVAPRIRSS-----GVAR-------EHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ 3260
Query: 2195 RHQTH------GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVR 2248
H G L L + +D+G Y C +G E + L T+ ++P I
Sbjct: 3261 DMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG--EDARLHTVNV-LVPPTIKQGA 3317
Query: 2249 IESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV----RGSRLYIFQASPA 2304
S + G+ + + C V G V+W K G LP + G L I + A
Sbjct: 3318 DGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLA 3377
Query: 2305 DAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQ----VAEGQTLDL 2360
DAG + C + + G N P +EP Q V G ++L
Sbjct: 3378 DAGIFTC---------VAASPAGVADRNFTLQV--QVPPVLEPVEFQNDVVVVRGSLVEL 3426
Query: 2361 NCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASV 2420
C G V+W K G L + G L+L DSG Y C + +
Sbjct: 3427 PCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHF 3486
Query: 2421 LVT------IEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG 2474
+T IE +G L +TP G ++L C G +TWHK G
Sbjct: 3487 QLTVMEPPHIEDSGQPTELSLTP-------------GAPMELLCDAQGTPQPNITWHKDG 3533
Query: 2475 GSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAY 2534
+L R + + R+L+V D+G Y C +G E S V +Q + +G +
Sbjct: 3534 QAL-TRLENNSRATRVLRVR--DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRF 3590
Query: 2535 PVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP----SRHQIVGSRLRIPQV 2590
V LA G L L C V ++ ITW++ G L ++ G L++ +
Sbjct: 3591 VV-------GLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQAL 3642
Query: 2591 TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLN 2650
+ ADSG+Y C N AGS + V I P IR + V QT L
Sbjct: 3643 STADSGDYSCTARNAAGSTSVAFRVEIH---------TVPTIRSGPPAVNVSVNQTALLP 3693
Query: 2651 CVVARQPQAIITWYKRGGSLPSRHQT-----HGSHLRLHQMSVADSGEYVCRANNNIDAL 2705
C P +++W K L R GS LR+ + D+G Y+C A+N+ +
Sbjct: 3694 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 3752
Query: 2706 EASIVISV-SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRG 2764
+ V P A +PS ++ + L C G V W K G
Sbjct: 3753 RQGRDLRVLEPPAIAPSPSNLTLTAHTPAL-----------LPCEASGSPKPLVVWWKDG 3801
Query: 2765 GSLPSHHQTRGSRLR------LHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAV 2818
L Q RL L P DS ++ C V G VT V
Sbjct: 3802 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVT--------V 3853
Query: 2819 HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH---- 2874
HVP P I + + V + L C G V+W K G L AR +
Sbjct: 3854 HVP-----PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP 3908
Query: 2875 GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 2934
L + Q P +G Y+C S+G V +T++ +SP P P + +
Sbjct: 3909 SGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ-ASPVVKPLPSVVRA-------- 3959
Query: 2935 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH---GSQLRLHLVSPADSGEYVC 2991
V E + L L C G +TW K G ++ T G QLR+ SP D+G Y+C
Sbjct: 3960 -VAEEEVL-LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 4017
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
A + G + V P PVI P + +G A C P
Sbjct: 4018 IAKNSAGSAMGKTRLVVQVP----------PVIENGLPDLSTTEGSHAFLPCKARGSPEP 4067
Query: 3052 ISLEWKTRNQEL---EDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV 3108
++ W Q + E I P+G ++ + + GTY C A NA G A+ V+L++
Sbjct: 4068 -NITWDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRARRRVHLTI 4125
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGL--MDS 3166
P + LP G +++G + L C + G P WT ++ P T G+ D
Sbjct: 4126 LVLPVFTTLP-GDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-----TEGVSEQDG 4178
Query: 3167 HAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE-A 3225
+ LQ ++ D+GTYVC A+N +G Q V V AP +Q E VE
Sbjct: 4179 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE------APVLQGEAFSYLVEPV 4232
Query: 3226 GHTATLRCSATGSPAPTIHWSKLRSPLPW---QHRLEGDTLIIPRVAQQDSGQYICNATS 3282
G + L C G P P IHW K PL +H+L+ +L I R + D+G+Y C A +
Sbjct: 4233 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAEN 4292
Query: 3283 PAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR 3342
G A+ +IL ++S P P+ +V++G+ V L+C A G P T +W + G P R
Sbjct: 4293 EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ--PLR 4350
Query: 3343 ATAR-----NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP----GSLPATS 3393
A+ R + L E D+G Y C N +GSA A A L+V+G P GS+ T
Sbjct: 4351 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSM--TG 4408
Query: 3394 IPAG---STPTVQVTPQLETKSIGASVEFHCA-VPSDRGTQLR----------W--FKEG 3437
+ G T+ + E S +S+ VP++ G +R W +E
Sbjct: 4409 VINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHVPANVGPLMRVLVVTIAPIYWALARES 4468
Query: 3438 GQLPPGHSVQDGVLR 3452
G+ GHS+ G R
Sbjct: 4469 GEALNGHSLTGGRFR 4483
Score = 426 bits (1095), Expect = e-118
Identities = 541/2114 (25%), Positives = 786/2114 (37%), Gaps = 290/2114 (13%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQ--GSELHFPSVQPSDAGVYICTCRNLH 1752
+L C G P W E G PV + R + GS L S + +G+Y C
Sbjct: 1615 ALECVARGHPSPTLSWHHE-GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA---- 1669
Query: 1753 QSNTSRAELLVTEAPSKPITVTVEEQRSQ-SVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
S A L + P + V E Q + G + C A S SP T+ W L N
Sbjct: 1670 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQW--LQN 1726
Query: 1812 GKLPTRAMDFNGI--------LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS--- 1860
G+ A + G+ L I +V+L +G + C +N + GTA V+ S
Sbjct: 1727 GR---PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN----EAGTAGAEVEVSVHG 1779
Query: 1861 ----GTLSAPVVSIH--------------PPQLTVQPGQLAEFRCSAT-GSPTPTLEWTG 1901
G L P+ H PP V G A + G +P W G
Sbjct: 1780 EWAPGVLEVPIGQYHWGXEHHSSFPAACDPP---VHRGWGAHPKPPLVEGWCSPGSLW-G 1835
Query: 1902 GPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVS 1961
P G +P + L++ V+ D+ Y C A + AG+ L V P ++
Sbjct: 1836 EPTG-IPVAYSLPPP-LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP--PNIEPG 1891
Query: 1962 PERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIATLLIPAITTA 2018
P V +V L C A+GVP ++W K G P + T D L I +
Sbjct: 1892 PVNKAVLENASVTLECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLS 1949
Query: 2019 DAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPS-VTEGQTLDLNCVVAGS 2077
DAG Y CVA++ AG+ + R + V PP + + S P V + L C G+
Sbjct: 1950 DAGSYRCVASNVAGSTELRYGLRV-----NVPPRITLPPSLPGPVLVNTPVRLTCNATGA 2004
Query: 2078 AHAQVTWYRRGGSLPPH----TQVH--GSRLRLPQVSPADSGEYVCRVENGSGPKEASIT 2131
+ W + G + P QV G L L +DSG Y C + G +
Sbjct: 2005 PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 2064
Query: 2132 VSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGS 2191
+ V H PS I E + V +++ L C ++W K G
Sbjct: 2065 LQV----HMPPS----------ILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRP 2110
Query: 2192 LPARHQTHGS----LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
L R H S LL++ + D+G Y C + +G E + + + P+ P+
Sbjct: 2111 LEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA----PVFPL 2166
Query: 2248 RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH------QVRGSRLYIFQA 2301
R ES + TV EG LSC G +++W K G LP G LY+ QA
Sbjct: 2167 R-ESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 2225
Query: 2302 SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPI---RIEPSSSQVAEGQTL 2358
A G Y C SN V G +L I R P+ V +
Sbjct: 2226 QLAQEGTYTCECSN---------VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 2276
Query: 2359 DLNCVVPGQSHAQVTWHKRG----GSLPVRHQTHGSLLRLYQASPADSGEYVC---RVLG 2411
L C G+ VTW + G L ++ Q G L + +A A +G Y C + G
Sbjct: 2277 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 2336
Query: 2412 SSV-PLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTW 2470
+ E SVLV E G + L ++ A L L C G + W
Sbjct: 2337 RAERKFELSVLVPPELIGDLDPL----------TNITAALHSPLTLLCEAMGIPPPAIRW 2386
Query: 2471 HKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSG 2526
+ + + G L++ Q DSG Y C +G + V
Sbjct: 2387 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE------- 2439
Query: 2527 SHSQGVAYPVRIESSSAS----LANGHTLDLNCLVASQAPHTITWYKRGGSLP--SRHQI 2580
V P IE+ + +G T L C V +TW+K G L H I
Sbjct: 2440 -----VLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHI 2494
Query: 2581 V--GSRLRIPQVTPADSGEYVCHVSNGAGSR------ETSLIVTIQGSGSSHVPSVSPPI 2632
G L++ Q + +G Y C +N G + L TI G
Sbjct: 2495 SPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA------- 2547
Query: 2633 RIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQ------THGSHLRLHQM 2686
TV + L C P ITW K G + THG L++
Sbjct: 2548 ---DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNA 2602
Query: 2687 SVADSGEYVCRANNNI-DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLD 2745
D+G+Y C N + +A++ V + P + S P + ++ + + TL
Sbjct: 2603 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN----STLT 2658
Query: 2746 LNCVVPGQAHAQVTWHKRGGSLPSHHQTR----GSRLRLHHVSPADSGEYVCRVMGSSGP 2801
L C + W+K G + + + G L++ +DSG Y+C +G
Sbjct: 2659 LECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGE 2718
Query: 2802 LEASVLVTIEASG--------SSAVHV-----PAPGGAPPIRIEPSSSRVAEGQTLDLKC 2848
+ V I+ S+A + A GG R + E L C
Sbjct: 2719 DDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR------EIVENNPAYLYC 2772
Query: 2849 VVPGQAHAQVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGT--L 2902
+TW++ L A +V G +L++ V ++G YSC+ + G L
Sbjct: 2773 DTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWL 2832
Query: 2903 EASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRG 2962
+LV P G L + + + ASS T+ L C G ++W + G
Sbjct: 2833 HYELLVLTPPVILGDTEE--LVEEVTVNASS-------TVSLQCPALGNPVPTISWLQNG 2883
Query: 2963 --GSLPARHQT--HGSQLRLHLVSPADSGEYVCRAASGPGPEQEA-SFTVTVPPSEGSSY 3017
S R Q G L++ AD+ Y+C A + G ++ + V VPP
Sbjct: 2884 LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR----- 2938
Query: 3018 RLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELE--DNVHISPNGSI 3075
+ +D T S C +H P + W +Q L + V + P
Sbjct: 2939 -----IAGLDLEQVTAILNSSVSLPCDVHAHPNP-EVTWYKDSQALSLGEEVFLLPGTHT 2992
Query: 3076 ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP---VWVKVGKAVTL 3132
+ + R S+ G Y C A NA G Q +V LSV PP P GP V V+VG L
Sbjct: 2993 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 3052
Query: 3133 ECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALG 3192
C + P + W + P L QRT L L+I A+ SD G Y C N G
Sbjct: 3053 SCETDALPEPTVTWYK-DGQPLVLAQRTQALRGGQR-LEIQEAQVSDKGLYSCKVSNVAG 3110
Query: 3193 TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE-AGHTATLRCSATGSPAPTIHWSKLRSP 3251
A + + V P + + E + AG L C +G PAPT+ W K R P
Sbjct: 3111 EAVRTFTLTVQV------PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP 3164
Query: 3252 LPWQ--HRL--EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY--ATTVP 3305
+ H + G L + R+ +G Y C A + A ++ V P ++ V
Sbjct: 3165 VESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVA 3224
Query: 3306 EHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAAPED 3359
V G+ V+L C A G PP W + GS L R L + D
Sbjct: 3225 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 3284
Query: 3360 SGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF 3419
+G Y C N G + V PP A + T+ P G V
Sbjct: 3285 AGAYTCVAHNPAGEDARLHTVNVLVPP----TIKQGADGSGTLVSRP-------GELVTM 3333
Query: 3420 HCAVPSDRGTQLRWFKEGGQLPPGHSV----QDGVLRIQNLDQSCQGTYICQAHGPWGKA 3475
C V + W K+G LP LRI + + G + C A P G A
Sbjct: 3334 VCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVA 3393
Query: 3476 QASAQLVIQALPSVLINIRTSVQTVVV-GHAVEFECLALGDPKPQVTWSKVGGHLRPGIV 3534
+ L +Q +P VL + VVV G VE C A G P P V+W K G L +
Sbjct: 3394 DRNFTLQVQ-VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL 3452
Query: 3535 QSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI---SMPQEVRVPAGSA 3591
+ G +++ V D+G Y C A + AG + H L V P I P E+ + G+
Sbjct: 3453 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 3512
Query: 3592 AVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKV- 3650
C A G P P+I+W K +L +RLENN +R +DAG Y C A + G +
Sbjct: 3513 MELLCDAQGTPQPNITWHKDGQAL---TRLENNSRATRVLRVRDAGLYTCLAESPAGAIE 3569
Query: 3651 KAF-AHLQVPERVV 3663
K+F +Q P +V
Sbjct: 3570 KSFRVRVQAPPNIV 3583
Score = 381 bits (978), Expect = e-105
Identities = 424/1641 (25%), Positives = 635/1641 (38%), Gaps = 282/1641 (17%)
Query: 2140 SGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL-PARH-- 2196
SG SY+ V + + P H Q L ++C V ++ + L RH
Sbjct: 416 SGVSYSGVAPGAPLVSMAPRI-HGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERHFQ 474
Query: 2197 QTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTV 2256
++ S + + + A+ G Y C V +G A +A ++ PP + + + TV
Sbjct: 475 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRA------KAQIVVTDPPPQLVPAPNVTV 528
Query: 2257 AEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH----QVRGSRLYIFQASPADAGQYVCR 2312
+ G+T LSC V G+A +TW + LPA Q+ L I P D G+Y C
Sbjct: 529 SPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCV 588
Query: 2313 ASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQV 2372
ASN G A++ + I SS ++G + ++C G +
Sbjct: 589 ASNA---------NGVTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHI 639
Query: 2373 TWHKRGGSLPVRHQTH----GSLLRLYQASPADSGEYVCRVLGS-SVPLEASVLVTIEPA 2427
+W + +L + H G+L+ + +P D+G Y C+ E L +P
Sbjct: 640 SWSRESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDP- 697
Query: 2428 GSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGS- 2486
P+V ++ VA G+ L C +G +V W++ G + + S
Sbjct: 698 ---------PSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG 748
Query: 2487 RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLA 2546
+LR+ D+G Y CR V G A + + + G Q P ++
Sbjct: 749 KLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV-----GHAPQLTELP-----RDVTVE 798
Query: 2547 NGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV---GSRLRIPQ--------VTPADS 2595
G + L C + P T+TW +RG P ++ GSR R P V P D
Sbjct: 799 LGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQ 857
Query: 2596 GEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVV-A 2654
YVC N G + + + G + S +P +R V+EGQ + L C+V A
Sbjct: 858 APYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVR-------VLEGQPVSLPCIVLA 910
Query: 2655 RQPQAIITWYKRGGSLP--SRHQTHGS-HLRLHQMSVADSGEYVCRANNNIDALEASIVI 2711
+P W K G LP SRH L L + +G Y C A N + + +
Sbjct: 911 GRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVEL 970
Query: 2712 SVSPSAGSPSAPGSSMPIRIESSSSH--VAEGETLDLNCVVPGQAHAQVTWHKRGGSL-- 2767
V +P RI +++H EG L CV G +TW K +L
Sbjct: 971 VVQ------------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTS 1018
Query: 2768 --PSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2825
P ++ ++ L + S D+G YVC + G
Sbjct: 1019 RGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVG------------------------- 1053
Query: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSP 2885
+ +++ V A ++ W + G LP+ LRL QV
Sbjct: 1054 ---------------FSSQEMRLSVNRLALSKYVWEEYG-LLPSGS------LRLAQVQV 1091
Query: 2886 ADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLN 2945
DSG Y C + +G+ ++ ++ P P P + + V G+ LDLN
Sbjct: 1092 GDSGHYECTASNPAGSASHRYVLGVQVP-PQVQPGPRVLK----------VLVGEALDLN 1140
Query: 2946 CVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHL--VSPADSGEYVCRAASGPGPEQ-E 3002
CV G Q++W K G L R G Q +H + +D+G Y C A++ G + E
Sbjct: 1141 CVAEGNPEPQLSWSKDGVVLQGR----GPQGSVHFAAIRTSDAGRYRCEASNSAGVDAWE 1196
Query: 3003 ASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQ--GQDASFKCLIHDGAAPISLEWKTRN 3060
V PP G+ D S +++ G++AS C P + W R
Sbjct: 1197 VELRVLEPPHWGA-----------DETSGLLERVAGENASLPCPARGTPKP-QVTW--RK 1242
Query: 3061 QELEDNVHISPNGSIIT-----IVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVS 3115
+ +H P +++ + P++ G Y C A+N G L V+ PP S
Sbjct: 1243 GPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPP--S 1300
Query: 3116 VLPEGP---VWVKVGKAVTLECVSAGEPRSSARWTRISS-TPAKLEQRTYG--------- 3162
+ +G V G+++TLEC + G P W + + L YG
Sbjct: 1301 IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360
Query: 3163 ---LMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEA 3219
L+D L + D+G Y C A+N GTAQ+ ++V T GA Q
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ---- 1416
Query: 3220 ELTVEAGHTATLRCSATGSPAPTIHWSKLRSP-LPWQHRLE----GDTLIIPRVAQQDSG 3274
E+ AG L+C +G P P + W+K R P LP L+ G L I D G
Sbjct: 1417 EVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEG 1476
Query: 3275 QYICNATSPAGHAEATIILHVESPP--YATTVPEHASVQAGETVQLQCLAHGTPPLTFQW 3332
+Y C A SPAG L V +PP + + +V VQL C A G P W
Sbjct: 1477 RYQCVAFSPAGQQARDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITW 1536
Query: 3333 SRVGSSLPGRA----TARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGS 3388
+ G+ LP T L RA D+G Y C+ +N VG+AE +L V PP
Sbjct: 1537 FKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP-- 1594
Query: 3389 LPATSIPAGSTPTVQVTPQLETKSI-GASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ 3447
T AG P V K++ G V C L W EG LP S +
Sbjct: 1595 ---TIEGAGGRPYV-------VKAVAGRPVALECVARGHPSPTLSWHHEG--LPVAESNE 1642
Query: 3448 -----DG-VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVV 3501
DG VLR+++ ++ G Y C A P G+A + +Q P +L+ T +
Sbjct: 1643 SRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTI 1702
Query: 3502 VGHAVEFECLALGDPKPQVTWSKVGGHLRPG-------IVQSGGVVRIAHVELADAGQYR 3554
VG +E C A G P P + W + G RP + G + I HVEL +G +
Sbjct: 1703 VGQPLELPCQASGSPVPTIQWLQNG---RPAEELAGVQVASQGTTLHIDHVELDHSGLFA 1759
Query: 3555 CTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAG------------------------S 3590
C ATN AGT + V + V P + VP G
Sbjct: 1760 CQATNEAGTAGAEVEVSVHG---EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWG 1816
Query: 3591 AAVFPCIASGYPTPDISWSKLDG-----SLPPDSRLENNMLMLPSVRPQDAGTYVCTATN 3645
A P + G+ +P W + G SLPP ++E V +D G Y C ATN
Sbjct: 1817 AHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIE-------KVDLRDEGIYTCAATN 1869
Query: 3646 RQGKVKAFAHLQ--VPERVVP 3664
G+ K L+ VP + P
Sbjct: 1870 LAGESKREVALKVLVPPNIEP 1890
Score = 335 bits (858), Expect = 8e-91
Identities = 356/1403 (25%), Positives = 544/1403 (38%), Gaps = 206/1403 (14%)
Query: 2386 QTHGSLLRLYQASPADSGEYVCRVLGSSVP--LEASVLVTIEPAGSVPALGVTPTVRIES 2443
++ S + +AS A+ G Y C + + +A ++VT P VPA VT
Sbjct: 475 ESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT------- 527
Query: 2444 SSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARH----QVHGSRLRLLQVTPADSG 2499
V+ G+T L+C V G+A +TW + LPA Q+ L + + P D G
Sbjct: 528 ----VSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGG 583
Query: 2500 EYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVAS 2559
Y C ++G ASV + +++ A V I +SS + G + ++C +
Sbjct: 584 RYQCVASNANGVTRASVWLLVRE----------APQVSIHTSSQHFSQGVEVKVSCSASG 633
Query: 2560 QAPHTITWYKRGGSLPSRHQI---VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVT 2616
I+W + +L +I L I V P D+G Y C +N G+ + + VT
Sbjct: 634 YPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQET--VT 691
Query: 2617 IQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQT 2676
+ + V +V+ + V G+ L C + P + WY+ G + +
Sbjct: 692 LYYTDPPSVSAVNAVV-------LVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEG 744
Query: 2677 HGS-HLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSS 2735
S LR+ D+G Y CRA N + A I ++V + P
Sbjct: 745 SSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELPRDVT-------- 796
Query: 2736 SHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT---RGSRLR--------LHHVS 2784
V G + L C G+ VTW +RG P + RGSR R V+
Sbjct: 797 --VELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVA 853
Query: 2785 PADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTL 2844
P D YVC G ++A + + H P P I + RV EGQ +
Sbjct: 854 PEDQAPYVCEARNVFGKVQAEARLIVTG------HAP-----PQIASSAPTVRVLEGQPV 902
Query: 2845 DLKCVV-PGQAHAQVTWHKRGGNLP--ARHQVHGP-LLRLNQVSPADSGEYSCQVTGSSG 2900
L C+V G+ + W K G LP +RH + L L++ +G YSC T ++G
Sbjct: 903 SLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAG 962
Query: 2901 TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT-EGQTLDLNCVVPGQAHAQVTWY 2959
+ V + ++ P ++ H+T EG L CV G +TW
Sbjct: 963 SQHRDVELVVQ------------VPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWT 1010
Query: 2960 KRGGSLPAR--HQTHGSQLRLHLVSPA--DSGEYVCRAASGPG-PEQEASFTVT------ 3008
K +L +R H + L + P+ D+G YVC A + G QE +V
Sbjct: 1011 KETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSK 1070
Query: 3009 --------VP-----------------------PSEGSSYRLR-----SPVISIDPPSST 3032
+P P+ +S+R P + P
Sbjct: 1071 YVWEEYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLK 1130
Query: 3033 VQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCV 3092
V G+ C+ P L W L+ P GS+ R S+ G YRC
Sbjct: 1131 VLVGEALDLNCVAEGNPEP-QLSWSKDGVVLQGR---GPQGSV-HFAAIRTSDAGRYRCE 1185
Query: 3093 ASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKV-GKAVTLECVSAGEPRSSARWTRISS 3151
ASN+ GV V L V PP + +V G+ +L C + G P+ W + S
Sbjct: 1186 ASNSAGVDAWEVELRVLEPPHWGADETSGLLERVAGENASLPCPARGTPKPQVTWRKGPS 1245
Query: 3152 TPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGA 3211
+ Q +++ ++ ++S P+D+G Y C A N +G+ ++ +++V P +
Sbjct: 1246 SEPLHGQPGVAVLEEGSLF-LASVSPADSGDYECQATNEVGSTSRRAKLVV----YVPPS 1300
Query: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSPLPWQ------------ 3255
+ +A ++ AG + TL C A G P P I W K + PL W
Sbjct: 1301 IREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVG 1360
Query: 3256 -HRL--EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQ- 3311
HRL EG +L PR+ + DSG Y C A + AG A+ L V +PP V
Sbjct: 1361 GHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLG 1420
Query: 3312 -AGETVQLQCLAHGTPPLTFQWSRVGSS-LPG----RATARNELLHFERAAPEDSGRYRC 3365
AG V+LQC G P +W++ LPG + ++L + D GRY+C
Sbjct: 1421 LAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQC 1480
Query: 3366 RVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPS 3425
+ G QL V PP GS T +V + V+ C
Sbjct: 1481 VAFSPAGQQARDFQLRVHAPPTIW-------GSNETGEVAVMEDHL-----VQLLCEARG 1528
Query: 3426 DRGTQLRWFKEGGQLPPGHSVQ----DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQL 3481
+ WFK+G LP V L++ S G Y C+A G A+ + +L
Sbjct: 1529 VPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRL 1588
Query: 3482 VIQALPSVL-INIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG----IVQS 3536
+ P++ R V V G V EC+A G P P ++W G + +
Sbjct: 1589 DVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETD 1648
Query: 3537 GGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ---EVRVPAGSAAV 3593
G V+R+ A +G Y C A++ AG + VQ PQ+ + + +V G
Sbjct: 1649 GSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLE 1708
Query: 3594 FPCIASGYPTPDISWSKLDGSLPPDSRL------ENNMLMLPSVRPQDAGTYVCTATNRQ 3647
PC ASG P P I W L P + + L + V +G + C ATN
Sbjct: 1709 LPCQASGSPVPTIQW--LQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEA 1766
Query: 3648 GKVKAFAHLQVPERVVPYFTQTP 3670
G A + V P + P
Sbjct: 1767 GTAGAEVEVSVHGEWAPGVLEVP 1789
Score = 247 bits (630), Expect = 2e-64
Identities = 204/711 (28%), Positives = 291/711 (40%), Gaps = 57/711 (8%)
Query: 2998 GPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWK 3057
G + E + + V S +P++S+ P Q C +H A P L+ +
Sbjct: 404 GKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLH-QPLLVSCSVHS-ALPFRLQLR 461
Query: 3058 TRNQELEDNVHISPNG-SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV 3116
L + H +G S I+ + GTY C A + G ++ + V PP +
Sbjct: 462 RGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP-QL 520
Query: 3117 LPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK 3176
+P V V G+ L C GE + W R R L D L+IS
Sbjct: 521 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS--LEISGII 578
Query: 3177 PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT 3236
P+D G Y C+A NA G + V ++V APQV + G + CSA+
Sbjct: 579 PTDGGRYQCVASNANGVTRASVWLLVRE------APQVSIHTSSQHFSQGVEVKVSCSAS 632
Query: 3237 GSPAPTIHWSKLRSPLPWQHRLEGD---TLIIPRVAQQDSGQYICNATSPAGHAEATIIL 3293
G P P I WS+ L R+ D TLII VA +D+G Y C AT+ G + T+ L
Sbjct: 633 GYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL 692
Query: 3294 HVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL----PGRATARNEL 3349
+ PP + V V GE L C A G PP W R G + G ++ +
Sbjct: 693 YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK--- 749
Query: 3350 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 3409
L A D+G Y CR N++G A A QL V G P + P+
Sbjct: 750 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV--------------GHAPQLTELPRDV 795
Query: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG-----------HSVQDGVLRIQNLDQ 3458
T +G S C + W + GQ P G GVL +++
Sbjct: 796 TVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGSRSRQPDSGVLFFESVAP 854
Query: 3459 SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLAL-GDPK 3517
Q Y+C+A +GK QA A+L++ I V+ G V C+ L G P
Sbjct: 855 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 914
Query: 3518 PQVTWSKVGGHLRPG---IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQA 3574
P+ W K G L PG +++ G + + AG+Y C ATN AG+ V L+VQ
Sbjct: 915 PERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV 974
Query: 3575 LPQISMPQEVRVP-AGSAAVFPCIASGYPTPDISWSKLDGSL----PPDSRLENNMLMLP 3629
P+I + G A PC+ASG P P I+W+K +L P + + L++
Sbjct: 975 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIA 1034
Query: 3630 SVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIK 3680
QDAG YVCTATN G L V + + Y LP +++
Sbjct: 1035 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNRLALSKYVWEEYGLLPSGSLR 1085
Score = 51.6 bits (122), Expect = 2e-05
Identities = 37/115 (32%), Positives = 49/115 (42%), Gaps = 4/115 (3%)
Query: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVK 470
PP ++ S QT C A GVP P+++WR + +P PR G+L I+ V
Sbjct: 3679 PP--AVNVSVNQTALLPCQADGVPAPLVSWRKD--RVPLDPRSPRFEILPEGSLRIQPVL 3734
Query: 471 ESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFG 525
D G Y C A N+ G D + P P P H+ A LPC G
Sbjct: 3735 AQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASG 3789
Score = 48.1 bits (113), Expect = 2e-04
Identities = 32/95 (33%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 1674 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRH-QGSELH 1732
Q+ V +V P V G +LRCQ +G P W + G+P+ + + R L
Sbjct: 4306 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRASRRLRTLPDGSLW 4364
Query: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP 1767
+V+ DAG Y C NL S T+RA L+V P
Sbjct: 4365 LENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 4399
Score = 47.0 bits (110), Expect = 4e-04
Identities = 37/116 (31%), Positives = 48/116 (41%), Gaps = 15/116 (12%)
Query: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAI 431
++ CV+TN S H D E +PP++ I + G + CVA
Sbjct: 952 RYSCVATNTA--GSQHRDVELVVQ--------VPPRIHPTATHHI-TNEGVPASLPCVAS 1000
Query: 432 GVPTPIINWRLNWGHIPSH-PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
GVP P I W + S P V+ E GTL+I D GAY C A N G
Sbjct: 1001 GVPAPTITWTKETNALTSRGPHYNVSKE---GTLLIAQPSAQDAGAYVCTATNTVG 1053
Score = 47.0 bits (110), Expect = 4e-04
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 9/84 (10%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PPQV PR ++ G+ + CVA G P P ++W S V + G +G+
Sbjct: 1118 VPPQVQPGPRV-LKVLVGEALDLNCVAEGNPEPQLSW--------SKDGVVLQGRGPQGS 1168
Query: 464 LIIRDVKESDQGAYTCEAMNARGM 487
+ ++ SD G Y CEA N+ G+
Sbjct: 1169 VHFAAIRTSDAGRYRCEASNSAGV 1192
Score = 46.6 bits (109), Expect = 5e-04
Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 402 GCMPPQVVTPPRESIQASRGQTVTFTCVAI-GVPTPIINWRLNWGHIPSHPRVTVTSEGG 460
G PPQ+ + +++ GQ V+ C+ + G P P +W + +P R ++ ++G
Sbjct: 881 GHAPPQIASSA-PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG- 938
Query: 461 RGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLP 520
+L + + G Y+C A N G + V+++ P+ P H E A LP
Sbjct: 939 --SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLP 996
Query: 521 CFCFGI 526
C G+
Sbjct: 997 CVASGV 1002
Score = 46.2 bits (108), Expect = 7e-04
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 3/68 (4%)
Query: 419 SRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYT 478
S+G V +C A G PTP I+W + R+ V ++G TLII+ V D G Y+
Sbjct: 620 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYS 676
Query: 479 CEAMNARG 486
C+A N G
Sbjct: 677 CQATNEVG 684
Score = 45.1 bits (105), Expect = 0.002
Identities = 27/63 (42%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 424 VTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMN 483
V C A GVPTP I W + +P+ +V T GGR L + + SD G YTC+A N
Sbjct: 1520 VQLLCEARGVPTPNITWFKDGALLPTSTKVVYT-RGGR-QLQLGRAQSSDAGVYTCKASN 1577
Query: 484 ARG 486
A G
Sbjct: 1578 AVG 1580
Score = 45.1 bits (105), Expect = 0.002
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 2/82 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP P E++ G + TC GVP P + W + + S V S GGR
Sbjct: 3122 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGR-- 3179
Query: 464 LIIRDVKESDQGAYTCEAMNAR 485
L + ++ + G YTC A N +
Sbjct: 3180 LQLSRLQPAQAGTYTCVAENTQ 3201
Score = 42.4 bits (98), Expect = 0.010
Identities = 24/68 (35%), Positives = 31/68 (45%), Gaps = 5/68 (7%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSH--PRVTVTSEGGRGTLIIRDVKESDQGAYT 478
G+ + C A G P P + WR P H P V V E G+L + V +D G Y
Sbjct: 1221 GENASLPCPARGTPKPQVTWRKGPSSEPLHGQPGVAVLEE---GSLFLASVSPADSGDYE 1277
Query: 479 CEAMNARG 486
C+A N G
Sbjct: 1278 CQATNEVG 1285
Score = 42.0 bits (97), Expect = 0.013
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP + P +VT C+A GVP P ++W + S VTV+ +G
Sbjct: 1884 VPPNIEPGPVNKAVLENA-SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG--RV 1940
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L I + SD G+Y C A N G
Sbjct: 1941 LRIEQAQLSDAGSYRCVASNVAG 1963
Score = 42.0 bits (97), Expect = 0.013
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 4/85 (4%)
Query: 404 MPPQVV--TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR 461
+PP+++ P +I A+ +T C A+G+P P I W G P P G
Sbjct: 2348 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLAGG 2405
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
L + +E D G Y+C A N G
Sbjct: 2406 WMLKMTQTQEQDSGLYSCLASNEAG 2430
Score = 40.8 bits (94), Expect = 0.030
Identities = 25/84 (29%), Positives = 38/84 (45%), Gaps = 2/84 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRG 462
+PP++ PP V TC A G P+P + W + + P+ GGR
Sbjct: 1975 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR- 2033
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
L + + SD G Y+C A++A G
Sbjct: 2034 VLTLASARASDSGRYSCVAVSAVG 2057
Score = 40.8 bits (94), Expect = 0.030
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 11/88 (12%)
Query: 408 VVTPPR---------ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSE 458
V+TPP E + + TV+ C A+G P P I+W N PR+ V +
Sbjct: 2838 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 2897
Query: 459 GGRGTLIIRDVKESDQGAYTCEAMNARG 486
G L + + +D +Y C A N G
Sbjct: 2898 G--QVLQVSTAEVADAASYMCVAENQAG 2923
Score = 40.4 bits (93), Expect = 0.039
Identities = 29/89 (32%), Positives = 36/89 (40%), Gaps = 9/89 (10%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR---- 461
PQ+ PR+ + G++ C A G P P + WR G P R+ G R
Sbjct: 786 PQLTELPRD-VTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGA-GRGSRSRQP 842
Query: 462 --GTLIIRDVKESDQGAYTCEAMNARGMV 488
G L V DQ Y CEA N G V
Sbjct: 843 DSGVLFFESVAPEDQAPYVCEARNVFGKV 871
Score = 40.0 bits (92), Expect = 0.051
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 384 ASFHCDEESDCPDRSDEFGC---MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINW 440
AS+ C E+ F +PP++ E + A +V+ C P P + W
Sbjct: 2912 ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW 2971
Query: 441 RLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ + V + G TL + + SD G YTCEA+NA G
Sbjct: 2972 YKDSQALSLGEEVFLLP--GTHTLQLGRARLSDSGMYTCEALNAAG 3015
Score = 40.0 bits (92), Expect = 0.051
Identities = 39/135 (28%), Positives = 54/135 (40%), Gaps = 5/135 (3%)
Query: 405 PPQVVTP--PRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
PP +V P PR + + GQ V C P P I W + G + T E GR
Sbjct: 3579 PPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHRD-GIVLQEDAHTQFPERGR- 3635
Query: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCF 522
L ++ + +D G Y+C A NA G + VP P + A LPC
Sbjct: 3636 FLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQ 3695
Query: 523 CFGITSVCQSTRRFR 537
G+ + S R+ R
Sbjct: 3696 ADGVPAPLVSWRKDR 3710
Score = 39.7 bits (91), Expect = 0.067
Identities = 23/68 (33%), Positives = 34/68 (50%), Gaps = 4/68 (5%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSH--PRVTVTSEGGRGTLIIRDVKESDQGAYT 478
GQ V C A G P P + W + + P + +GG +L+++ ++ SD GAYT
Sbjct: 3232 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYT 3289
Query: 479 CEAMNARG 486
C A N G
Sbjct: 3290 CVAHNPAG 3297
Score = 38.9 bits (89), Expect = 0.11
Identities = 28/102 (27%), Positives = 41/102 (40%), Gaps = 24/102 (23%)
Query: 404 MPPQVVTPPRES-IQASRGQTVTFTCVAIGVPTPII------------------NWRLNW 444
+PP + R++ + GQ++T C A G P P I W L W
Sbjct: 1297 VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 1356
Query: 445 GHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
G + H + EG +L ++E D G Y+C A N G
Sbjct: 1357 GQVGGH---RLLDEG--QSLHFPRIQEGDSGLYSCRAENQAG 1393
Score = 38.9 bits (89), Expect = 0.11
Identities = 34/115 (29%), Positives = 46/115 (40%), Gaps = 5/115 (4%)
Query: 408 VVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIR 467
VV P ++A + V C A G+P P I W+ ++ + V G L I
Sbjct: 3949 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP---GGQLRIA 4005
Query: 468 DVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQ-RGPCPDGHFYLEHSAACLPC 521
D G Y C A N+ G G V+++ P PD E S A LPC
Sbjct: 4006 HASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPC 4059
Score = 38.5 bits (88), Expect = 0.15
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 6/84 (7%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRGT 463
PPQ+V P ++ S G+T +C +G + W +W +P S RV ++ +
Sbjct: 517 PPQLVPAP--NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD---LS 571
Query: 464 LIIRDVKESDQGAYTCEAMNARGM 487
L I + +D G Y C A NA G+
Sbjct: 572 LEISGIIPTDGGRYQCVASNANGV 595
Score = 38.1 bits (87), Expect = 0.19
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
+ ++ T+T C + VP P I W + + R+ V EG L I+ + SD
Sbjct: 2647 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVSD 2704
Query: 474 QGAYTCEAMNARG 486
G Y C A N G
Sbjct: 2705 SGRYLCVATNVAG 2717
Score = 37.7 bits (86), Expect = 0.25
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 8/93 (8%)
Query: 396 DRSDEFGCMPPQVVTPP--RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRV 453
DR+ P V+ P + + RG V C A GVP P+++W + P +
Sbjct: 3394 DRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD-----GEPLL 3448
Query: 454 TVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ + E G +L + V D G Y+C A++ G
Sbjct: 3449 SQSLEQG-PSLQLEAVGAGDSGTYSCVAVSEAG 3480
Score = 37.4 bits (85), Expect = 0.33
Identities = 27/84 (32%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Query: 404 MPPQV-VTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
+PPQ+ V + GQ + C A G P P I W N V V S+G
Sbjct: 1686 VPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG--T 1743
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
TL I V+ G + C+A N G
Sbjct: 1744 TLHIDHVELDHSGLFACQATNEAG 1767
Score = 37.4 bits (85), Expect = 0.33
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
MPP ++ ++ ++V C + +P P+++W + P PR V +
Sbjct: 2069 MPPSILGEEL-NVSVVANESVALECQSHAMPPPVLSWWKDGR--PLEPRPGVHLSADKAL 2125
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L + D G YTCEA+N G
Sbjct: 2126 LQVDRADVWDAGHYTCEALNQAG 2148
Score = 37.0 bits (84), Expect = 0.43
Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 4/81 (4%)
Query: 409 VTPPRES--IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSH-PRVTVTSEGGRGTLI 465
V P RES + G + +C GVP P I+WR + +P + S GR L
Sbjct: 2163 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR-LLY 2221
Query: 466 IRDVKESDQGAYTCEAMNARG 486
+ + + +G YTCE N G
Sbjct: 2222 LGQAQLAQEGTYTCECSNVVG 2242
Score = 36.2 bits (82), Expect = 0.74
Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 4/82 (4%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRGTL 464
P V+ + + G C A G P P I W + + + + T+ G L
Sbjct: 4037 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG---EL 4093
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
++++++ D G YTC A NA G
Sbjct: 4094 LVKNLEGQDAGTYTCTAENAVG 4115
Score = 36.2 bits (82), Expect = 0.74
Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 3/66 (4%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G V C A G PTP I W + + R+ + G+L + +V+ D G Y C
Sbjct: 4323 GDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD---GSLWLENVETGDAGTYDCV 4379
Query: 481 AMNARG 486
A N G
Sbjct: 4380 AHNLLG 4385
Score = 35.4 bits (80), Expect = 1.3
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P V+ + + G+ C A GVP P + W + + G L
Sbjct: 697 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-----YRGGLEMILAPEGSSSGKLR 751
Query: 466 IRDVKESDQGAYTCEAMNARG 486
I +E D G YTC A+N G
Sbjct: 752 IPAAQERDAGTYTCRAVNELG 772
Score = 35.4 bits (80), Expect = 1.3
Identities = 27/121 (22%), Positives = 41/121 (33%), Gaps = 2/121 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P + + + V TC + G+P P ++W + + S G L
Sbjct: 3856 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSG--ALE 3913
Query: 466 IRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFG 525
I G YTC A N+ G+ ++ P P P + LPC G
Sbjct: 3914 IGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASG 3973
Query: 526 I 526
I
Sbjct: 3974 I 3974
Score = 35.4 bits (80), Expect = 1.3
Identities = 22/66 (33%), Positives = 27/66 (40%), Gaps = 4/66 (6%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G + C A G PTP I W +N + V+ + G TL V D G Y C
Sbjct: 4143 GDRLWLRCAARGSPTPRIGWTVNDRPVTE----GVSEQDGGSTLQRAAVSREDSGTYVCW 4198
Query: 481 AMNARG 486
A N G
Sbjct: 4199 AENRVG 4204
Score = 35.0 bits (79), Expect = 1.6
Identities = 28/109 (25%), Positives = 42/109 (38%), Gaps = 13/109 (11%)
Query: 386 FHCDEESDCPDRSDEFGCMPPQVVTPPR-------ESIQASRGQTVTFTCVAIGVPTPII 438
+ C E+ +F + V+TPP + + G V C GVPTP +
Sbjct: 1384 YSCRAENQAGTAQRDFHLL---VLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV 1440
Query: 439 NWRLNWGHI-PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
W + + P P + V +G L I D+G Y C A + G
Sbjct: 1441 EWTKDRQPVLPGGPHLQVQEDG--QVLRITGSHVGDEGRYQCVAFSPAG 1487
Score = 35.0 bits (79), Expect = 1.6
Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 4/85 (4%)
Query: 404 MPPQVVTPPRESIQASRGQ--TVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR 461
+PPQ+ P Q S Q T C A G P P + W + + + + + ++G
Sbjct: 2254 VPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG-- 2311
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
+L + + + G Y+C A N G
Sbjct: 2312 QSLHVERAQAAHTGRYSCVAENLAG 2336
Score = 35.0 bits (79), Expect = 1.6
Identities = 21/86 (24%), Positives = 37/86 (43%), Gaps = 5/86 (5%)
Query: 404 MPP---QVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG 460
+PP Q P++++ G +C +P P + W + + R G
Sbjct: 3027 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 3086
Query: 461 RGTLIIRDVKESDQGAYTCEAMNARG 486
R L I++ + SD+G Y+C+ N G
Sbjct: 3087 R--LEIQEAQVSDKGLYSCKVSNVAG 3110
Score = 34.7 bits (78), Expect = 2.1
Identities = 21/59 (35%), Positives = 28/59 (47%), Gaps = 8/59 (13%)
Query: 3848 CRDRP-CQNGGQCHDSESSSYVCVCPAGF----TGSRCEHSQALHCHPEACGPDATCVN 3901
CR R CQ+ C ++E S Y C+CPAG+ +G C+ CGP C N
Sbjct: 4873 CRVRNLCQHA--CRNTEGS-YQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFN 4928
Score = 32.7 bits (73), Expect = 8.2
Identities = 18/71 (25%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
++A G+ V CVA G P+P ++W + + ++G L + E+ G
Sbjct: 1606 VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG--SVLRLESPGEASSG 1663
Query: 476 AYTCEAMNARG 486
Y+C A + G
Sbjct: 1664 LYSCVASSPAG 1674
>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3783
Score = 519 bits (1336), Expect = e-146
Identities = 538/2081 (25%), Positives = 820/2081 (39%), Gaps = 252/2081 (12%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAGVYI 1745
V G + L C V+G P W + DGRP+ G G L S AG Y
Sbjct: 1175 VLDGQTAHLMCNVTGHPQPKLTWFK-DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 1233
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
C N T +L V AP+ +V ++ IC A + P+ +
Sbjct: 1234 CIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALA-FPSPNIT 1292
Query: 1806 WTR---LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA--- 1859
W + + + L I N Q DAG Y C +N + + HV+
Sbjct: 1293 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN--ELGEAVKNYHVEVLIP 1350
Query: 1860 -SGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPA-KAQI--HG 1915
S + P+ + ++ + C + P PT+ W P+ + Q+ G
Sbjct: 1351 PSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG 1410
Query: 1916 GILRLPAVEPTDQAQYLCRAHSSAGQ--QVARAVLHVH------GGGGPRVQVSPERTQV 1967
+L++ + +D +YLC A + AG+ Q ++ V G ++ +
Sbjct: 1411 RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 1470
Query: 1968 HAGRT----------VRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA----TLLIP 2013
G T LYC +P +TW +E P + + + L IP
Sbjct: 1471 RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED---QPLSAGDEVSVLQGGRVLQIP 1527
Query: 2014 AITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTE-----GQTL 2068
+ +AG Y C A++ G +++VL+ PPV + + V E T+
Sbjct: 1528 LVRAENAGRYSCKASNEVGEDWLHYELLVLT------PPVILGDTEELVEEVTVNASSTV 1581
Query: 2069 DLNCVVAGSAHAQVTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSG 2124
L C G+ ++W + G P ++ G L++ AD+ Y+C EN +G
Sbjct: 1582 SLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG 1641
Query: 2125 PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVT 2184
E T+ V VP + +E ++ + ++ L C V + +VT
Sbjct: 1642 SAEKLFTLRV-----------QVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 1688
Query: 2185 WHKRGGSLPARHQ------THGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238
W+K +L + TH L+L + +DSG Y C + +G LV +
Sbjct: 1689 WYKDSQALSLGEEVFLLPGTH--TLQLGRARLSDSGMYTCEALNAAG--RDQKLVQLSVL 1744
Query: 2239 VIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR----GS 2294
V P R + V G LSC VTWYK G L + + G
Sbjct: 1745 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1804
Query: 2295 RLYIFQASPADAGQYVCRASN-GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVA 2353
RL I +A +D G Y C+ SN EA T T+T P T SQVA
Sbjct: 1805 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETV--------SQVA 1856
Query: 2354 EGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ------THGSLLRLYQASPADSGEYVC 2407
G L L C V G VTW K +PV + G L+L + PA +G Y C
Sbjct: 1857 -GSPLVLTCDVSGVPAPTVTWLK--DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTC 1913
Query: 2408 RVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQ 2467
+ +V + A + + GV + V EGQ + L+C GQ
Sbjct: 1914 VAENTQAEARKDFVVAVLVAPRIRSSGV-------AREHHVLEGQEVRLDCEADGQPPPD 1966
Query: 2468 VTWHKRGGSLPA------RHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQ 2521
V W K G L R + G L L + +D+G Y C +G E + L T+
Sbjct: 1967 VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG--EDARLHTVN 2024
Query: 2522 QRLSGSHSQGVAYPVRIESSSASLAN--GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQ 2579
+ + QG S +L + G + + C V P ++W K G LP +
Sbjct: 2025 VLVPPTIKQGA-------DGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQR 2077
Query: 2580 IV----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIE 2635
+ G LRI +V AD+G + C ++ AG + + + +Q VP V P+ +
Sbjct: 2078 TLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ------VPPVLEPVEFQ 2131
Query: 2636 SSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYV 2695
+ VV G ++L C P +++W K G L S+ G L+L + DSG Y
Sbjct: 2132 NDV-VVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYS 2190
Query: 2696 CRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH 2755
C A + ++V P S P + + G ++L C G
Sbjct: 2191 CVAVSEAGEARRHFQLTVMEP---PHIEDSGQPTELS-----LTPGAPMELLCDAQGTPQ 2242
Query: 2756 AQVTWHKRGGSLPS-HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASG 2814
+TWHK G +L + +R +R+ + D+G Y C +G +E S V ++A
Sbjct: 2243 PNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAESPAGAIEKSFRVRVQA-- 2296
Query: 2815 SSAVHVPAPGGAPPIRIEPSSSR----VAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP-- 2868
PP + P R +A GQ L L+C V + ++TWH+ G L
Sbjct: 2297 ------------PPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQED 2343
Query: 2869 --ARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQP 2926
+ G L+L +S ADSG+YSC ++G+ + V I +P P
Sbjct: 2344 AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT-----VPTIRSGPP 2398
Query: 2927 IYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHG----SQLRLHLVS 2982
+ +V+ QT L C G V+W K L R LR+ V
Sbjct: 2399 ------AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVL 2452
Query: 2983 PADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFK 3042
D+G Y+C A++ G +++ + P P I+ P + T+ A
Sbjct: 2453 AQDAGHYLCLASNSAGSDRQGRDLRVLEP----------PAIAPSPSNLTLTAHTPALLP 2502
Query: 3043 CLIHDGAAPISLEWKTRNQELEDNVH------ISPNGSIITIVGTRPSNHGTYRCVASNA 3096
C P+ + WK Q+L+ + + N ++T G P + + CV SN
Sbjct: 2503 CEASGSPKPLVVWWKD-GQKLDFRLQQGAYRLLPSNALLLTAPG--PQDSAQFECVVSNE 2559
Query: 3097 YGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKL 3156
G A + ++VH PPT++ + V + V L C S G P + W++ A+L
Sbjct: 2560 VGEAHRLYQVTVHVPPTIAD-DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAG---AQL 2615
Query: 3157 EQRTYGLMDSHA-VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQ 3215
R G S + L+I A P AG Y C A+N+ G A K V + V + P V
Sbjct: 2616 GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVV 2675
Query: 3216 AEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSPLPWQHRLEGDTLIIPRVAQQ 3271
AE V L C A+G P PTI W K + + + Q L G L I + +
Sbjct: 2676 RAVAEEEV------LLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQLRIAHASPE 2728
Query: 3272 DSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQ 3331
D+G Y+C A + AG A L V+ PP S G L C A G+P
Sbjct: 2729 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT 2788
Query: 3332 WSRVG---SSLPGRATAR--NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 3386
W + G S G+ T + ELL + +D+G Y C N VG A L +
Sbjct: 2789 WDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRARRRVHLTIL--- 2844
Query: 3387 GSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV 3446
P P + +G + CA ++ W + G S
Sbjct: 2845 -----------VLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE 2893
Query: 3447 QDGVLRIQN--LDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGH 3504
QDG +Q + + GTY+C A G+ QA + + ++ P VL S VG
Sbjct: 2894 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGG 2952
Query: 3505 AVEFECLALGDPKPQVTWSKVGGHLRPGIVQ---SGGVVRIAHVELADAGQYRCTATNAA 3561
+++ +C+ GDP P + W K G LR ++ G + I E DAG+Y+C A N
Sbjct: 2953 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAENEM 3012
Query: 3562 GTTQSHVLLLVQALPQISM-PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR 3620
G + V+L++Q+ P + PQ++ V +G C A+G PTP I W + L R
Sbjct: 3013 GVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRR 3072
Query: 3621 LE---NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
L + L L +V DAGTY C A N G A A L V
Sbjct: 3073 LRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3113
Score = 491 bits (1264), Expect = e-138
Identities = 538/2116 (25%), Positives = 814/2116 (38%), Gaps = 270/2116 (12%)
Query: 1683 PARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPS--GTQQRHQGSELHFPSVQPSD 1740
P + V Q G +L C +G PP W R DG+PV + G Q ++QG LH Q +
Sbjct: 983 PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAH 1041
Query: 1741 AGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP 1800
G Y C NL + EL V P + ++ + + + +T +C A P
Sbjct: 1042 TGRYSCVAENLAGRAERKFELSVLVPPE--LIGDLDPLTNITAALHSPLTLLCEAMGIPP 1099
Query: 1801 AYTLVWTRLHNGKLP---TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV 1857
+ W R P T + +L + Q D+G Y C SN + ++ V
Sbjct: 1100 P-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1158
Query: 1858 QASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH--- 1914
++ + + V GQ A C+ TG P P L W G+ A+ H
Sbjct: 1159 LVPPSIENEDLE---EVIKVLDGQTAHLMCNVTGHPQPKLTWF--KDGRPLARGDAHHIS 1213
Query: 1915 --GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGG---GPRVQVSPERTQVHA 1969
G +L++ + Y C A ++ G++ L V G + E V
Sbjct: 1214 PDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1273
Query: 1970 GRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT----LLIPAITTADAGFYLC 2025
+ L C A PS ITW K+G P S + L I DAG Y C
Sbjct: 1274 NNPISLICEALAFPSPNITWMKDGA---PFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1330
Query: 2026 VATSPAGTAQARIQVVVLSASDASP--PPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2083
V T+ G A V VL S P ++ TL L C +
Sbjct: 1331 VVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1390
Query: 2084 WYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTH 2139
WY+ G + P +++ G L++ +DSG Y+C N +G + V +
Sbjct: 1391 WYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----Q 1446
Query: 2140 SGPSYTPVPGSTRPIRIEPSSSHVAEGQT--------------LDLNCVVPGQAHAQVTW 2185
P + V + I G T D N + P +TW
Sbjct: 1447 VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPP----PDLTW 1502
Query: 2186 HKRGGSLPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGP--LEASVLVTIEASV 2239
++ L A + G +L++ V ++G Y C G L +LV
Sbjct: 1503 YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT---- 1558
Query: 2240 IPGPIPPVRIESSSSTVAE-----GQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR-- 2292
PPV + + V E T+ L C G ++W + G LP R
Sbjct: 1559 -----PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQ 1611
Query: 2293 ----GSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPS 2348
G L + A ADA Y+C A N ++ + Q Q I S
Sbjct: 1612 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNS 1671
Query: 2349 SSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ------THGSLLRLYQASPADS 2402
S + L C V + +VTW+K +L + + TH L+L +A +DS
Sbjct: 1672 S--------VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH--TLQLGRARLSDS 1721
Query: 2403 GEYVCRVLGSSVP----LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC 2458
G Y C L ++ ++ SVLV PA P R + V G L+C
Sbjct: 1722 GMYTCEALNAAGRDQKLVQLSVLVP-------PAFRQAP--RGPQDAVLVRVGDKAVLSC 1772
Query: 2459 LVAGQAHAQVTWHKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCRVVGSSGTQEA 2514
VTW+K G L + G RL + + +D G Y C+V +G
Sbjct: 1773 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1832
Query: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL 2574
+ +T+Q + + + + + S G L L C V+ T+TW K +
Sbjct: 1833 TFTLTVQVPPTFENPK---------TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV 1883
Query: 2575 PSR--HQIV--GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
S H +V G RL++ ++ PA +G Y C N +V + V+P
Sbjct: 1884 ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVL---------VAP 1934
Query: 2631 PIRIESSSPT--VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH------GSHLR 2682
IR + V+EGQ + L+C QP + W K G L H G L
Sbjct: 1935 RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLV 1994
Query: 2683 LHQMSVADSGEYVCRANNNI--DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAE 2740
L + +D+G Y C A+N DA ++ + V P+ A GS +
Sbjct: 1995 LKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTI-KQGADGSGTLVS--------RP 2045
Query: 2741 GETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT----RGSRLRLHHVSPADSGEYVCRVM 2796
GE + + C V G V+W K G LP +T G LR+ V AD+G + C
Sbjct: 2046 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2105
Query: 2797 GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSR----VAEGQTLDLKCVVPG 2852
+G + + + ++ PP+ +EP + V G ++L C G
Sbjct: 2106 SPAGVADRNFTLQVQV--------------PPV-LEPVEFQNDVVVVRGSLVELPCEARG 2150
Query: 2853 QAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEP 2912
V+W K G L ++ GP L+L V DSG YSC +G +T+
Sbjct: 2151 VPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-- 2208
Query: 2913 SSPGPIPAPGLAQPIYIEASSS----HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR 2968
+P +IE S +T G ++L C G +TW+K G +L R
Sbjct: 2209 -----------MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-TR 2256
Query: 2969 HQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV--PPSEGSSYRLRSP--VI 3024
+ + R+ V D+G Y C A S P E SF V V PP+ R P V+
Sbjct: 2257 LENNSRATRVLRVR--DAGLYTCLAES-PAGAIEKSFRVRVQAPPNIVGP---RGPRFVV 2310
Query: 3025 SIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTR 3082
+ P ++ C + AP + W L+++ H G + +
Sbjct: 2311 GLAPGQLVLE--------CSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALS 2361
Query: 3083 PSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRS 3142
++ G Y C A NA G + +H PT+ P V V V + L C + G P
Sbjct: 2362 TADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPA-VNVSVNQTALLPCQADGVPAP 2420
Query: 3143 SARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV-I 3201
W R P + ++ + L+I DAG Y+CLA N+ G+ ++ ++ +
Sbjct: 2421 LVSW-RKDRVPLDPRSPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV 2478
Query: 3202 VDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR---- 3257
++ A+AP + LT+ A A L C A+GSP P + W K L ++ +
Sbjct: 2479 LEPPAIAPSP-------SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY 2531
Query: 3258 --LEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGET 3315
L + L++ QDS Q+ C ++ G A + V PP +V
Sbjct: 2532 RLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP 2591
Query: 3316 VQLQCLAHGTPPLTFQWSRVGSSLPGRAT----ARNELLHFERAAPEDSGRYRCRVTNKV 3371
V L C + G P T WS+ G+ L R + + + L +A P +GRY C N
Sbjct: 2592 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 2651
Query: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQL 3431
G A L VQ ++P V+ P + V C +
Sbjct: 2652 GVAHKHVFLTVQ--------------ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTI 2697
Query: 3432 RWFKEGGQLPPGHSVQ---DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
W KEG + G S Q G LRI + G Y+C A G A +LV+Q +P
Sbjct: 2698 TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ-VPP 2756
Query: 3489 VLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK----VGGHLRPGIVQSGGVVRIAH 3544
V+ N + T HA C A G P+P +TW K V G +Q G + + +
Sbjct: 2757 VIENGLPDLSTTEGSHAF-LPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 2815
Query: 3545 VELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVFPCIASGYPT 3603
+E DAG Y CTA NA G + V L + LP + +P + + G C A G PT
Sbjct: 2816 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 2875
Query: 3604 PDISWSKLDGSLPPDSRLEN--NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPER 3661
P I W+ D + ++ + L +V +D+GTYVC A NR G+ +A + + V E
Sbjct: 2876 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE- 2934
Query: 3662 VVPYFTQTPYSFLPLP 3677
P +S+L P
Sbjct: 2935 -APVLQGEAFSYLVEP 2949
Score = 490 bits (1262), Expect = e-137
Identities = 525/1981 (26%), Positives = 793/1981 (40%), Gaps = 238/1981 (12%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQ-QRHQGSE-LHFPSVQPSDAGVYICTCRNL- 1751
SL C+ P W + DG P + Q G+ L + Q DAG Y C N
Sbjct: 1278 SLICEALAFPSPNITWMK-DGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNEL 1336
Query: 1752 -HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLH 1810
E+L+ + SK + + + + +T C + + P T+ W +
Sbjct: 1337 GEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPP-TIRWYKDG 1395
Query: 1811 NGKLPTRAMDFNG---ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS------G 1861
P+ + G +L I+ Q+SD+G Y+C +N+ D + +Q G
Sbjct: 1396 QPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVG 1455
Query: 1862 TLSAPVVSIHPPQLTVQPGQLAEFR-----------CSATGSPTPTLEW--TGGPGGQLP 1908
SA + + G + E+R C P P L W P
Sbjct: 1456 DFSAAFEILSREEEA--RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 1513
Query: 1909 AKAQIHGG-ILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP----- 1962
+ + GG +L++P V + +Y C+A + G+ L V P V +
Sbjct: 1514 EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT---PPVILGDTEELV 1570
Query: 1963 ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE-RTDIATLLIPAITTADAG 2021
E V+A TV L C A G P TI+W + G P R + D L + ADA
Sbjct: 1571 EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAA 1630
Query: 2022 FYLCVATSPAGTAQA----RIQVVVLSASDASPPPVK-IESSSPSVTEGQTLDLNCVVAG 2076
Y+CVA + AG+A+ R+QV PP + ++ + ++ L C V
Sbjct: 1631 SYMCVAENQAGSAEKLFTLRVQV---------PPRIAGLDLEQVTAILNSSVSLPCDVHA 1681
Query: 2077 SAHAQVTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITV 2132
+ +VTWY+ +L +V L+L + +DSG Y C N +G + + +
Sbjct: 1682 HPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 1741
Query: 2133 SVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE-GQTLDLNCVVPGQAHAQVTWHKRGGS 2191
SVL VP + R P + + G L+C VTW+K G
Sbjct: 1742 SVL-----------VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1790
Query: 2192 LPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
L +T G L + + +D G Y C V +G + +T++ +PP
Sbjct: 1791 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ-------VPPT 1843
Query: 2248 RIESSSSTVAE--GQTLDLSCVVAGQAHAQVTWYKRGGSLP--ARHQV--RGSRLYIFQA 2301
+ TV++ G L L+C V+G VTW K + A H V RG RL + +
Sbjct: 1844 FENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRL 1903
Query: 2302 SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLN 2361
PA AG Y C A N + V A +G + V EGQ + L+
Sbjct: 1904 QPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR-------EHHVLEGQEVRLD 1956
Query: 2362 CVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVL 2421
C GQ V W K G L Q G LR Y D G V + L +S A
Sbjct: 1957 CEADGQPPPDVAWLKDGSPLG---QDMGPHLRFY----LDGGSLVLKGLRAS-DAGAYTC 2008
Query: 2422 VTIEPAGSVPALG-----VTPTVR--IESSSSQVAE-GQTLDLNCLVAGQAHAQVTWHKR 2473
V PAG L V PT++ + S + V+ G+ + + C V G V+W K
Sbjct: 2009 VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 2068
Query: 2474 GGSLPA--RHQVHGS--RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHS 2529
G LP R +HGS LR+ +V AD+G + C +G + + + +Q
Sbjct: 2069 GLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV------- 2121
Query: 2530 QGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQ 2589
V PV ++ + G ++L C ++W K G L S+ G L++
Sbjct: 2122 PPVLEPVEFQNDVV-VVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEA 2180
Query: 2590 VTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT---VVEGQT 2646
V DSG Y C + AG +T+ + PP +S PT + G
Sbjct: 2181 VGAGDSGTYSCVAVSEAGEARRHFQLTV----------MEPPHIEDSGQPTELSLTPGAP 2230
Query: 2647 LDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALE 2706
++L C PQ ITW+K G +L +R + + R+ + V D+G Y C A + A+E
Sbjct: 2231 MELLCDAQGTPQPNITWHKDGQAL-TRLENNSRATRV--LRVRDAGLYTCLAESPAGAIE 2287
Query: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGS 2766
S + V P+ G P + +A G+ L L C V + ++TWH+ G
Sbjct: 2288 KSFRVRVQ---APPNIVGPRGPRFVVG----LAPGQ-LVLECSVEAEPAPKITWHRDGIV 2339
Query: 2767 LPSHHQT----RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPA 2822
L T RG L+L +S ADSG+Y C ++G + V I
Sbjct: 2340 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT---------- 2389
Query: 2823 PGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL----L 2878
P IR P + V+ QT L C G V+W K L R L L
Sbjct: 2390 ---VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSL 2446
Query: 2879 RLNQVSPADSGEYSCQVTGSSGT-LEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
R+ V D+G Y C + S+G+ + L +EP + P P S+ +T
Sbjct: 2447 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSP------------SNLTLT 2494
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGP 2997
L C G V W+K G L R Q +L P+++ + P
Sbjct: 2495 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL-----PSNA-----LLLTAP 2544
Query: 2998 GPEQEASFTVTVPPSEGSSYRLRS------PVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
GP+ A F V G ++RL P I+ D TV C AP
Sbjct: 2545 GPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAP 2604
Query: 3052 ISLEWKTRNQELE---DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV 3108
++ W +L +SP+G++ I P + G Y C A N+ GVA V L+V
Sbjct: 2605 -TVSWSKAGAQLGARGSGYRVSPSGAL-EIGQALPIHAGRYTCSARNSAGVAHKHVFLTV 2662
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHA 3168
P V LP V + V L C ++G PR + W + A T L
Sbjct: 2663 QASPVVKPLPS-VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT-GVSTQVLPGGQ- 2719
Query: 3169 VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHT 3228
L+I+ A P DAG Y+C+A+N+ G+A + ++V P ++ +L+ G
Sbjct: 2720 -LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQV------PPVIENGLPDLSTTEGSH 2772
Query: 3229 ATLRCSATGSPAPTIHWSKLRSPLPWQHRL----EGDTLIIPRVAQQDSGQYICNATSPA 3284
A L C A GSP P I W K P+ L++ + QD+G Y C A +
Sbjct: 2773 AFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2832
Query: 3285 GHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRAT 3344
G A + L + P TT+P S++ G+ + L+C A G+P W+ + +
Sbjct: 2833 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS 2892
Query: 3345 ARNELLHFERAAP--EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTV 3402
++ +RAA EDSG Y C N+VG +A + + V+ P + G +
Sbjct: 2893 EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-------VLQGEAFSY 2945
Query: 3403 QVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGH---SVQDGVLRIQNLDQS 3459
V P +G S++ C V D + W K+G L H +Q+G L I+ ++
Sbjct: 2946 LVEP------VGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERD 2999
Query: 3460 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQ 3519
G Y C A G A+ LV+Q+ P + + TV G V C A G+P P
Sbjct: 3000 DAGRYQCLAENEMGVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPT 3057
Query: 3520 VTWSKVGGHLRPGI---VQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALP 3576
+ W + G LR G + + +VE DAG Y C A N G+ + L+V+ P
Sbjct: 3058 IEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Query: 3577 Q 3577
Q
Sbjct: 3118 Q 3118
Score = 486 bits (1250), Expect = e-136
Identities = 545/2126 (25%), Positives = 800/2126 (37%), Gaps = 255/2126 (11%)
Query: 1664 QGGQCLPETNQAPLVVEVHPARS----IVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVP 1719
Q G N V V P R V +G L C+ G P W R+DG+P+P
Sbjct: 864 QAGHSEKHYNLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISW-RKDGQPLP 922
Query: 1720 S-GTQQRHQ---GSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTV 1775
G +H G L+ Q + G Y C C N+ +++ +L V P I
Sbjct: 923 GEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ--IAGPR 980
Query: 1776 EEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN---GKLPTRAMDFNGILTIRNVQL 1832
E SV T C A K P T+ W R +L + + L + Q
Sbjct: 981 EPPTQVSVVQDGVATLECNATGKPPP-TVTWERDGQPVGAELGLQLQNQGQSLHVERAQA 1039
Query: 1833 SDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGS 1892
+ G Y C N+ + L V L + + +T C A G
Sbjct: 1040 AHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPL--TNITAALHSPLTLLCEAMGI 1097
Query: 1893 PTPTLEWTGGPGGQLPAKAQI---HGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLH 1949
P P + W G P + G +L++ + D Y C A + AG+ AR
Sbjct: 1098 PPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE--ARRNFS 1155
Query: 1950 VHGGGGPRVQVSP--ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPP-QARSERTD 2006
V P ++ E +V G+T L C G P +TW K+G L A D
Sbjct: 1156 VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPD 1215
Query: 2007 IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQ 2066
L + + AG Y C+A + G Q+ VL A +VT
Sbjct: 1216 GVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 1275
Query: 2067 TLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV------HGSRLRLPQVSPADSGEYVCRVE 2120
+ L C +TW + G + HG L++ D+G+Y C V
Sbjct: 1276 PISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVT 1333
Query: 2121 NGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAH 2180
N G + V VL + ++ + +S TL L C
Sbjct: 1334 NELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNS-------TLTLECESWAVPP 1386
Query: 2181 AQVTWHKRGGSLPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIE 2236
+ W+K G + + G LL++ +DSG Y+C +G + V I+
Sbjct: 1387 PTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQ 1446
Query: 2237 ASVIPGPIPPV---------------RIESSSSTVAEGQTLD------LSCVVAGQAHAQ 2275
+PP+ R E + V E + + L C
Sbjct: 1447 -------VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD 1499
Query: 2276 VTWYKRGGSLPARHQVR----GSRLYIFQASPADAGQYVCRASN--GMEASITVTVTGTQ 2329
+TWY+ L A +V G L I +AG+Y C+ASN G + + T
Sbjct: 1500 LTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTP 1559
Query: 2330 GANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG----GSLPVRH 2385
L + + + SS T+ L C G ++W + G S ++
Sbjct: 1560 PVILGDTEELVEEVTVNASS-------TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQV 1612
Query: 2386 QTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSS 2445
G +L++ A AD+ Y+C + E + ++ + L + I +SS
Sbjct: 1613 LEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSS 1672
Query: 2446 SQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL---------PARHQVHGSRLRLLQVTPA 2496
+ L C V + +VTW+K +L P H + R RL +
Sbjct: 1673 --------VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL-----S 1719
Query: 2497 DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCL 2556
DSG Y C + ++G + LV + + + Q P + + G L+C
Sbjct: 1720 DSGMYTCEALNAAGRDQK--LVQLSVLVPPAFRQAPRGP----QDAVLVRVGDKAVLSCE 1773
Query: 2557 VASQAPHTITWYKRGGSL--PSRHQIV--GSRLRIPQVTPADSGEYVCHVSNGAGSRETS 2612
+ T+TWYK G L R Q + G RL I + +D G Y C VSN AG +
Sbjct: 1774 TDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRT 1833
Query: 2613 LIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS 2672
+T+Q VP + E+ S V G L L C V+ P +TW K + S
Sbjct: 1834 FTLTVQ------VPPTFENPKTETVSQ--VAGSPLVLTCDVSGVPAPTVTWLKDRMPVES 1885
Query: 2673 RHQ----THGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMP 2728
+ G L+L ++ A +G Y C A N V++V +
Sbjct: 1886 SAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAP----------- 1934
Query: 2729 IRIESSS----SHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS------HHQTRGSRL 2778
RI SS HV EG+ + L+C GQ V W K G L G L
Sbjct: 1935 -RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSL 1993
Query: 2779 RLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRV 2838
L + +D+G Y C +G E + L T+ + A G +
Sbjct: 1994 VLKGLRASDAGAYTCVAHNPAG--EDARLHTVNVLVPPTIKQGADGSGTLVS-------- 2043
Query: 2839 AEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA--RHQVHGP--LLRLNQVSPADSGEYSCQ 2894
G+ + + C V G V+W K G LP R +HG LR+++V AD+G ++C
Sbjct: 2044 RPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCV 2103
Query: 2895 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 2954
+G + + + ++ P + +P+ + + V G ++L C G
Sbjct: 2104 AASPAGVADRNFTLQVQ--------VPPVLEPVEFQ-NDVVVVRGSLVELPCEARGVPLP 2154
Query: 2955 QVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGP-EQEASFTVTVPPSE 3013
V+W K G L ++ G L+L V DSG Y C A S G + TV PP
Sbjct: 2155 LVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHI 2214
Query: 3014 GSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNG 3073
S + P ++ G C P ++ W Q L + N
Sbjct: 2215 EDSGQ---------PTELSLTPGAPMELLCDAQGTPQP-NITWHKDGQAL---TRLENNS 2261
Query: 3074 SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKA---V 3130
++ R + G Y C+A + G + + V PP + V P GP +V VG A +
Sbjct: 2262 RATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFV-VGLAPGQL 2317
Query: 3131 TLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNA 3190
LEC EP W R E + LQ+ + +D+G Y C A+NA
Sbjct: 2318 VLECSVEAEPAPKITWHRDGIVLQ--EDAHTQFPERGRFLQLQALSTADSGDYSCTARNA 2375
Query: 3191 LGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRS 3250
G+ V + T P +++ + V TA L C A G PAP + W K R
Sbjct: 2376 AGSTSVAFRVEIHT------VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRV 2429
Query: 3251 PL----PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE 3306
PL P L +L I V QD+G Y+C A++ AG L V PP P
Sbjct: 2430 PLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPS 2489
Query: 3307 HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATAR------NELLHFERAAPEDS 3360
+ ++ A L C A G+P W + G L R + L P+DS
Sbjct: 2490 NLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQDS 2549
Query: 3361 GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420
++ C V+N+VG A Q+ V PP T+ T ++ A V
Sbjct: 2550 AQFECVVSNEVGEAHRLYQVTVHVPP--------------TIADDQTDFTVTMMAPVVLT 2595
Query: 3421 CAVPSDRGTQLRWFKEGGQLPP---GHSVQ-DGVLRIQNLDQSCQGTYICQAHGPWGKAQ 3476
C + W K G QL G+ V G L I G Y C A G A
Sbjct: 2596 CHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAH 2655
Query: 3477 ASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI--- 3533
L +QA P ++ SV V V C A G P+P +TW K G ++ G+
Sbjct: 2656 KHVFLTVQASP--VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQ 2713
Query: 3534 VQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI--SMPQEVRVPAGSA 3591
V GG +RIAH DAG Y C A N+AG+ L+VQ P I +P ++ GS
Sbjct: 2714 VLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLP-DLSTTEGSH 2772
Query: 3592 AVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPS-------VRPQDAGTYVCTAT 3644
A PC A G P P+I+W K DG P S E + PS + QDAGTY CTA
Sbjct: 2773 AFLPCKARGSPEPNITWDK-DGQ--PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAE 2829
Query: 3645 NRQGKVKAFAHLQVPERVVPYFTQTP 3670
N G+ + HL + V+P FT P
Sbjct: 2830 NAVGRARRRVHLTI--LVLPVFTTLP 2853
Score = 472 bits (1215), Expect = e-132
Identities = 535/2041 (26%), Positives = 785/2041 (38%), Gaps = 239/2041 (11%)
Query: 1731 LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPS-KPITVTVEEQRSQSVRPGADV 1789
L V D G+Y C NL + L V P+ +P V +++V A V
Sbjct: 568 LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPV------NKAVLENASV 621
Query: 1790 TFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN---GILTIRNVQLSDAGTYVCTGSNMF 1846
T C A P + W + H + + +L I QLSDAG+Y C SN+
Sbjct: 622 TLECLASGVPPP-DVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVA 680
Query: 1847 AMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTG----- 1901
+ L V ++ P S+ P L P +L C+ATG+P+PTL W
Sbjct: 681 GSTELRYGLRVNVPPRITLP-PSLPGPVLVNTPVRLT---CNATGAPSPTLMWLKDGNPV 736
Query: 1902 GPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVS 1961
P G + G +L L + +D +Y C A S+ G+ VL VH P +
Sbjct: 737 SPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVH--MPPSILGE 794
Query: 1962 PERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE-RTDIATLLIPAITTADA 2020
V A +V L C++ +P ++W K+G L P+ D A L + DA
Sbjct: 795 ELNVSVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDA 854
Query: 2021 GFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080
G Y C A + AG ++ + V A P ES + +V EG L+C G
Sbjct: 855 GHYTCEALNQAGHSEKHYNLNVWVA----PVFPLRESHTLTVREGHPTRLSCECRGVPFP 910
Query: 2081 QVTWYRRGGSLP------PHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
+++W + G LP H G L L Q A G Y C N G + + V
Sbjct: 911 KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 970
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKR----GG 2190
H P + G P P+ V + L C G+ VTW + G
Sbjct: 971 ----HVPPQ---IAGPREP----PTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGA 1019
Query: 2191 SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSG----PLEASVLVTIEASVIPGPIPP 2246
L + Q G L + + A +G Y C +G E SVLV E + G + P
Sbjct: 1020 ELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPE---LIGDLDP 1076
Query: 2247 VRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH------QVRGSRLYIFQ 2300
+ ++ T A L L C G + W++ G P G L + Q
Sbjct: 1077 L----TNITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLAGGWMLKMTQ 1130
Query: 2301 ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSS--QVAEGQTL 2358
D+G Y C ASN G N + I E +V +GQT
Sbjct: 1131 TQEQDSGLYSCLASN---------EAGEARRNFSVEVLVPPSIENEDLEEVIKVLDGQTA 1181
Query: 2359 DLNCVVPGQSHAQVTWHKRGGSLPVRHQTH-----GSLLRLYQASPADSGEYVC---RVL 2410
L C V G ++TW K G L R H G LL++ QA+ + +G Y C +
Sbjct: 1182 HLMCNVTGHPQPKLTWFKDGRPL-ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAV 1240
Query: 2411 GSSVP-LEASVLVTIEPAGSVPALGVTPTVRIESSSSQ---VAEGQTLDLNCLVAGQAHA 2466
G + SVL+ G E S+ + V + L C
Sbjct: 1241 GEKTKHFQLSVLLAPTILGGA-----------EDSADEEVTVTVNNPISLICEALAFPSP 1289
Query: 2467 QVTWHKRGGSLPARHQV------HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI 2520
+TW K G A + HG L++L D+G+Y C V G + V +
Sbjct: 1290 NITWMKDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEV 1347
Query: 2521 QQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL--PSRH 2578
S S +A + TL L C + P TI WYK G + SR
Sbjct: 1348 LIPPSISKDDPLA---EVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL 1404
Query: 2579 QIVGSRLRIPQVTP---ADSGEYVCHVSNGAGSRETSLIVTIQGSGS-SHVPSVSPPIRI 2634
Q++G R+ Q+ P +DSG Y+C +N AG + V IQ V S I
Sbjct: 1405 QVLGEG-RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEI 1463
Query: 2635 ESSSP----------TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH----GSH 2680
S +VE L C P +TWY+ L + + G
Sbjct: 1464 LSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRV 1523
Query: 2681 LRLHQMSVADSGEYVCRANNNI--DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHV 2738
L++ + ++G Y C+A+N + D L +++ ++P P G + + E + V
Sbjct: 1524 LQIPLVRAENAGRYSCKASNEVGEDWLHYELLV-LTP----PVILGDTEELVEEVT---V 1575
Query: 2739 AEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR------GSRLRLHHVSPADSGEYV 2792
T+ L C G ++W + G LP R G L++ AD+ Y+
Sbjct: 1576 NASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYM 1633
Query: 2793 CRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPG 2852
C +G A L T+ V P + +E ++ + ++ L C V
Sbjct: 1634 CVAENQAG--SAEKLFTL--------RVQVPPRIAGLDLEQVTAIL--NSSVSLPCDVHA 1681
Query: 2853 QAHAQVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLV 2908
+ +VTW+K L +V L+L + +DSG Y+C+ ++G + V +
Sbjct: 1682 HPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 1741
Query: 2909 TIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR 2968
++ + P Q + V G L+C VTWYK G L
Sbjct: 1742 SV-------LVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLA 1794
Query: 2969 HQTH----GSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVI 3024
+T G +L + +D G Y C+ ++ G E +FT+TV + P
Sbjct: 1795 QRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAG-EAVRTFTLTV----------QVPPT 1843
Query: 3025 SIDPPSSTVQQ--GQDASFKCLIHDGAAPISLEWKTRNQELEDNVH-ISPNGSIITIVGT 3081
+P + TV Q G C + AP K R VH + G + +
Sbjct: 1844 FENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRL 1903
Query: 3082 RPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV-SVLPEGPVWVKVGKAVTLECVSAGEP 3140
+P+ GTY CVA N A+ ++V P + S V G+ V L+C + G+P
Sbjct: 1904 QPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQP 1963
Query: 3141 RSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV 3200
W + S + L + + SDAG Y C+A N G + V
Sbjct: 1964 PPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTV 2023
Query: 3201 IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRL-- 3258
V + P Q L G T+ C GSP + W K PLP R
Sbjct: 2024 NV---LVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLL 2080
Query: 3259 --EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTV--PEHASVQAGE 3314
G TL I +V D+G + C A SPAG A+ L V+ PP V V G
Sbjct: 2081 HGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGS 2140
Query: 3315 TVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSA 3374
V+L C A G P W + G L ++ + L E DSG Y C ++ G A
Sbjct: 2141 LVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEA 2200
Query: 3375 EAFAQLLVQGPPGSLPATSIPAGSTPT-VQVTPQLETKSIGASVEFHCAVPSDRGTQLRW 3433
QL V PP I PT + +TP GA +E C + W
Sbjct: 2201 RRHFQLTVMEPP------HIEDSGQPTELSLTP-------GAPMELLCDAQGTPQPNITW 2247
Query: 3434 FKEGGQLP--PGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLI 3491
K+G L +S VLR+++ G Y C A P G + S ++ +QA P++
Sbjct: 2248 HKDGQALTRLENNSRATRVLRVRD-----AGLYTCLAESPAGAIEKSFRVRVQAPPNI-- 2300
Query: 3492 NIRTSVQTVVVGHA---VEFECLALGDPKPQVTWSKVGGHLRPG----IVQSGGVVRIAH 3544
+ VVG A + EC +P P++TW + G L+ + G +++
Sbjct: 2301 -VGPRGPRFVVGLAPGQLVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQA 2359
Query: 3545 VELADAGQYRCTATNAAGTTQSHVLLLVQALPQI-SMPQEVRVPAGSAAVFPCIASGYPT 3603
+ AD+G Y CTA NAAG+T + + +P I S P V V A+ PC A G P
Sbjct: 2360 LSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQADGVPA 2419
Query: 3604 PDISWSK----LDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVP 3659
P +SW K LD P L L + V QDAG Y+C A+N G + L+V
Sbjct: 2420 PLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVL 2479
Query: 3660 E 3660
E
Sbjct: 2480 E 2480
Score = 469 bits (1207), Expect = e-131
Identities = 525/2085 (25%), Positives = 802/2085 (38%), Gaps = 236/2085 (11%)
Query: 1676 PLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPS--GTQQRHQGSELHF 1733
P +E P V + S +L C SG PP W + +PV S G G L
Sbjct: 603 PPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFKGH-QPVSSWMGVTVSVDGRVLRI 661
Query: 1734 PSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFIC 1793
Q SDAG Y C N+ S R L V P +T+ V V C
Sbjct: 662 EQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPP----RITLPPSLPGPVLVNTPVRLTC 717
Query: 1794 TAKSKSPAYTLVWTRLHNGKLPT-----RAMDFNGILTIRNVQLSDAGTYVCTGSNMFAM 1848
A + +P+ TL+W + N P + +LT+ + + SD+G Y C +
Sbjct: 718 NA-TGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGE 776
Query: 1849 DQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLP 1908
D+ L V ++ +++ +V + C + P P L W G L
Sbjct: 777 DRQDVVLQVHMPPSILGEELNV-----SVVANESVALECQSHAMPPPVLSW-WKDGRPLE 830
Query: 1909 AKAQIH----GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPER 1964
+ +H +L++ + D Y C A + AG L+V ++ S
Sbjct: 831 PRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLRESHTL 890
Query: 1965 TQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT---LLIPAITTADAG 2021
T V G RL C GVP I+WRK+G LP + + A L + A G
Sbjct: 891 T-VREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEG 949
Query: 2022 FYLCVATSPAGTAQARIQVVV-LSASDASP--PPVKIESSSPSVTEGQTLDLNCVVAGSA 2078
Y C ++ G + +Q+ V + A P PP ++ SV + L C G
Sbjct: 950 TYTCECSNVVGNSSQDLQLEVHVPPQIAGPREPPTQV-----SVVQDGVATLECNATGKP 1004
Query: 2079 HAQVTWYRR----GGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
VTW R G L Q G L + + A +G Y C EN +G E +SV
Sbjct: 1005 PPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV 1064
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194
L P+ T + L L C G + W + +
Sbjct: 1065 LVPPELIGDLDPLTNITAALH-----------SPLTLLCEAMGIPPPAIRWFRGEEPVSP 1113
Query: 2195 RHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIE 2250
T+ G +L++ Q DSG Y C +G + V + ++P I +E
Sbjct: 1114 GEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV---LVPPSIENEDLE 1170
Query: 2251 SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL---PARH-QVRGSRLYIFQASPADA 2306
V +GQT L C V G ++TW+K G L A H G L + QA+ + A
Sbjct: 1171 EVIK-VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSA 1229
Query: 2307 GQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQ---VAEGQTLDLNCV 2363
G Y C A+N + T+ L+ T E S+ + V + L C
Sbjct: 1230 GHYSCIAANAVGEK-------TKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICE 1282
Query: 2364 VPGQSHAQVTWHKRGG------SLPVRHQTHGSLLRLYQASPADSGEYVCRV---LGSSV 2414
+TW K G ++ + THG L++ A D+G+Y C V LG +V
Sbjct: 1283 ALAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVTNELGEAV 1340
Query: 2415 PLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG 2474
V V I P+ S P + + TL L C + W+K G
Sbjct: 1341 K-NYHVEVLIPPSISKD----DPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDG 1395
Query: 2475 GSL--PARHQVHGSRLRLLQVTP---ADSGEYVCRVVGSSG--TQEASVLVTIQQRLSGS 2527
+ +R QV G RLLQ+ P +DSG Y+C +G Q+ +VL+ +
Sbjct: 1396 QPVTPSSRLQVLGEG-RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKV 1454
Query: 2528 HSQGVAYPVRIESSSA--------SLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQ 2579
A+ + A + + L C + P +TWY+ L + +
Sbjct: 1455 GDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE 1514
Query: 2580 IV----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIE 2635
+ G L+IP V ++G Y C SN G + + ++PP+ +
Sbjct: 1515 VSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLV----------LTPPVILG 1564
Query: 2636 SSSPTVVE-----GQTLDLNCVVARQPQAIITWYKRG--GSLPSRHQT--HGSHLRLHQM 2686
+ V E T+ L C P I+W + G S R Q G L++
Sbjct: 1565 DTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTA 1624
Query: 2687 SVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDL 2746
VAD+ Y+C A N + E + V P + +E ++ + ++ L
Sbjct: 1625 EVADAASYMCVAENQAGSAEKLFTLRV-------QVPPRIAGLDLEQVTAIL--NSSVSL 1675
Query: 2747 NCVVPGQAHAQVTWHKRGGS---------LPSHHQTRGSRLRLHHVSPADSGEYVCRVMG 2797
C V + +VTW+K + LP H + R RL +DSG Y C +
Sbjct: 1676 PCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL-----SDSGMYTCEALN 1730
Query: 2798 SSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQ 2857
++G + V +++ + P A +R+ G L C
Sbjct: 1731 AAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRV---------GDKAVLSCETDALPEPT 1781
Query: 2858 VTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPS 2913
VTW+K G L + G L + + +D G YSC+V+ +G + +T++
Sbjct: 1782 VTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ-- 1839
Query: 2914 SPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ--- 2970
+P P P + + G L L C V G VTW K +P
Sbjct: 1840 ----VP-PTFENP---KTETVSQVAGSPLVLTCDVSGVPAPTVTWLK--DRMPVESSAVH 1889
Query: 2971 ---THGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISID 3027
+ G +L+L + PA +G Y C A E F V V + R+RS ++ +
Sbjct: 1890 GVVSRGGRLQLSRLQPAQAGTYTC-VAENTQAEARKDFVVAVLVAP----RIRSSGVARE 1944
Query: 3028 PPSSTVQQGQDASFKCLIHDGAAPISLEW----KTRNQELEDNVHISPNGSIITIVGTRP 3083
V +GQ+ C DG P + W Q++ ++ +G + + G R
Sbjct: 1945 ---HHVLEGQEVRLDCEA-DGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRA 2000
Query: 3084 SNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE--GPVWVKVGKAVTLECVSAGEPR 3141
S+ G Y CVA N G + ++V PPT+ + G + + G+ VT+ C G P
Sbjct: 2001 SDAGAYTCVAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPP 2060
Query: 3142 SSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVI 3201
W + P L QRT L S L+IS + +DAG + C+A + G A + +
Sbjct: 2061 IHVSWLK-DGLPLPLSQRTL-LHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQ 2118
Query: 3202 VDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGD 3261
V P + + ++ V G L C A G P P + W K PL Q +G
Sbjct: 2119 V----QVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGP 2174
Query: 3262 TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYA--TTVPEHASVQAGETVQLQ 3319
+L + V DSG Y C A S AG A L V PP+ + P S+ G ++L
Sbjct: 2175 SLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAPMELL 2234
Query: 3320 CLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQ 3379
C A GTP W + G +L N D+G Y C + G+ E +
Sbjct: 2235 CDAQGTPQPNITWHKDGQAL---TRLENNSRATRVLRVRDAGLYTCLAESPAGAIEKSFR 2291
Query: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
+ VQ PP + P G V + P + C+V ++ ++ W ++G
Sbjct: 2292 VRVQAPPNIVG----PRGPRFVVGLAP--------GQLVLECSVEAEPAPKITWHRDGIV 2339
Query: 3440 LPPGHSVQ----DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRT 3495
L Q L++Q L + G Y C A G + ++ I +P+ I
Sbjct: 2340 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPT--IRSGP 2397
Query: 3496 SVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI----VQSGGVVRIAHVELADAG 3551
V V C A G P P V+W K L P + G +RI V DAG
Sbjct: 2398 PAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVLAQDAG 2457
Query: 3552 QYRCTATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVFPCIASGYPTPDISW-- 3608
Y C A+N+AG+ + L V P I+ P + + A + A+ PC ASG P P + W
Sbjct: 2458 HYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASGSPKPLVVWWK 2517
Query: 3609 --SKLDGSLPPDS--RLENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
KLD L + L +N L+L + PQD+ + C +N G+
Sbjct: 2518 DGQKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGE 2562
Score = 467 bits (1202), Expect = e-130
Identities = 543/2116 (25%), Positives = 798/2116 (37%), Gaps = 289/2116 (13%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSRED---GRPVP-------------SGTQQRHQGSELHFP 1734
G S +L C +G P W ++ G P+ G + +G LHFP
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92
Query: 1735 SVQPSDAGVYICTCRNLHQSNTSRAE--LLVTEAPSKPITVTVEEQRSQSVRPGADVTFI 1792
+Q D+G+Y C N Q+ T++ + LLV PS +E + GADV
Sbjct: 93 RIQEGDSGLYSCRAEN--QAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLA---GADVELQ 147
Query: 1793 CTAKSKSPAYTLVWTRLHNGKLP----TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAM 1848
C S P + WT+ LP + + +L I + D G Y C +
Sbjct: 148 CWT-SGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQ 206
Query: 1849 DQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLP 1908
L V A T+ S ++ V L + C A G PTP + W G LP
Sbjct: 207 QARDFQLRVHAPPTIWG---SNETGEVAVMEDHLVQLLCEARGVPTPNITWF-KDGALLP 262
Query: 1909 AKAQI----HGGILRLPAVEPTDQAQYLCRAHSSAG--QQVARAVLHV----HGGGGPRV 1958
++ G L+L + +D Y C+A ++ G ++ R ++V G GG
Sbjct: 263 TSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGG--- 319
Query: 1959 QVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE---RTDIATLLIPAI 2015
P + AGR V L C A G PS T++W EG LP +E TD + L + +
Sbjct: 320 --RPYVVKAVAGRPVALECVARGHPSPTLSWHHEG--LPVAESNESRLETDGSVLRLESP 375
Query: 2016 TTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTE--GQTLDLNCV 2073
A +G Y CVA+SPAG A V+ S PP + + VT GQ L+L C
Sbjct: 376 GEASSGLYSCVASSPAGEA-----VLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQ 430
Query: 2074 VAGSAHAQVTWYRRGGSLPPHTQV----HGSRLRLPQVSPADSGEYVCRVENGSGPKEAS 2129
+GS + W + G V G+ L + V SG + C+ N +G A
Sbjct: 431 ASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAE 490
Query: 2130 ITVSVLHGTHSGPSYTPVP----------GSTRPIRIEPSSSHVAEG----QTLDLNCVV 2175
+ VSV HG + P VP S+ P +P H G L
Sbjct: 491 VEVSV-HGEWA-PGVLEVPIGQYHWGXEHHSSFPAACDP-PVHRGWGAHPKPPLVEGWCS 547
Query: 2176 PGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSG--PLEASVLV 2233
PG + T SLP L++ +V D G Y C +G E ++ V
Sbjct: 548 PGSLWGEPTGIPVAYSLPPP-------LQIEKVDLRDEGIYTCAATNLAGESKREVALKV 600
Query: 2234 TIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH---- 2289
+ ++ PGP+ +E++S T L C+ +G V+W+K G P
Sbjct: 601 LVPPNIEPGPVNKAVLENASVT--------LECLASGVPPPDVSWFK--GHQPVSSWMGV 650
Query: 2290 --QVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEP 2347
V G L I QA +DAG Y C ASN V G+ I + P
Sbjct: 651 TVSVDGRVLRIEQAQLSDAGSYRCVASN---------VAGSTELRYGLRVNVPPRITLPP 701
Query: 2348 S-SSQVAEGQTLDLNCVVPGQSHAQVTWHKRG------GSLPVRHQTHGSLLRLYQASPA 2400
S V + L C G + W K G G+ ++ G +L L A +
Sbjct: 702 SLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARAS 761
Query: 2401 DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLV 2460
DSG Y C + + V++ + + P++ E + V +++ L C
Sbjct: 762 DSGRYSCVAVSAVGEDRQDVVLQVH---------MPPSILGEELNVSVVANESVALECQS 812
Query: 2461 AGQAHAQVTWHKRGGSLPARHQVHGSRLR-LLQVTPA---DSGEYVCRVVGSSGTQEASV 2516
++W K G L R VH S + LLQV A D+G Y C + +G E
Sbjct: 813 HAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHY 872
Query: 2517 LVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS 2576
+ + +P+R ES + ++ GH L+C I+W K G LP
Sbjct: 873 NLNVW--------VAPVFPLR-ESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPG 923
Query: 2577 RH------QIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
VG L + Q A G Y C SN G+ L + + HVP
Sbjct: 924 EGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV------HVPPQIA 977
Query: 2631 PIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKR----GGSLPSRHQTHGSHLRLHQM 2686
R + +VV+ L C +P +TW + G L + Q G L + +
Sbjct: 978 GPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERA 1037
Query: 2687 SVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDL 2746
A +G Y C A N E +SV P G P+ +++ H L L
Sbjct: 1038 QAAHTGRYSCVAENLAGRAERKFELSV---LVPPELIGDLDPLTNITAALH----SPLTL 1090
Query: 2747 NCVVPGQAHAQVTWHKRGGSLPSHHQT----RGSRLRLHHVSPADSGEYVCRVMGSSGPL 2802
C G + W + + T G L++ DSG Y C +G
Sbjct: 1091 LCEAMGIPPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAG-- 1148
Query: 2803 EASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSS--RVAEGQTLDLKCVVPGQAHAQVTW 2860
EA + +V V P P I E +V +GQT L C V G ++TW
Sbjct: 1149 --------EARRNFSVEVLVP---PSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTW 1197
Query: 2861 HKRGGNLPARHQVH-----GPLLRLNQVSPADSGEYSCQVTGSSG--TLEASVLVTIEPS 2913
K G L AR H G LL++ Q + + +G YSC + G T + V + P+
Sbjct: 1198 FKDGRPL-ARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPT 1256
Query: 2914 SPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ--- 2970
G G E + VT + L C +TW K G A
Sbjct: 1257 ILG-----GAEDSADEEVT---VTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQL 1308
Query: 2971 ---THGSQLRLHLVSPADSGEYVCRAASGPGPE-QEASFTVTVPPSEGSSYRLRSPVISI 3026
THG L++ D+G+Y C + G + V +PPS P+ +
Sbjct: 1309 LPGTHG--LQILNAQKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKD----DPLAEV 1362
Query: 3027 DPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNGSIITIVGTRPS 3084
+ + +C P ++ W Q + + + G ++ I T+ S
Sbjct: 1363 GVKEVKTKVNSTLTLECESW-AVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVS 1421
Query: 3085 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKV------------------ 3126
+ G Y CVA+N G N+ + PP + + ++
Sbjct: 1422 DSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIV 1481
Query: 3127 -GKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVC 3185
L C + P W R + ++ ++ VLQI + +AG Y C
Sbjct: 1482 ENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDE--VSVLQGGRVLQIPLVRAENAGRYSC 1539
Query: 3186 LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW 3245
A N +G E++V T + G + E E+TV A T +L+C A G+P PTI W
Sbjct: 1540 KASNEVGEDWLHYELLVLTPPVILGDTEELVE--EVTVNASSTVSLQCPALGNPVPTISW 1597
Query: 3246 SKLRSPLPWQHRL----EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYA 3301
+ P RL +G L + D+ Y+C A + AG AE L V+ PP
Sbjct: 1598 LQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRI 1657
Query: 3302 TTVP-EHASVQAGETVQLQCLAHGTPPLTFQWSRVGSS---------LPGRATARNELLH 3351
+ E + +V L C H P W + + LPG T L
Sbjct: 1658 AGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHT-----LQ 1712
Query: 3352 FERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETK 3411
RA DSG Y C N G + QL V PP A P G V V
Sbjct: 1713 LGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQA---PRGPQDAVLV------- 1762
Query: 3412 SIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ----DGVLRIQNLDQSCQGTYICQ 3467
+G C + + W+K+G L Q L IQ S +G Y C+
Sbjct: 1763 RVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCK 1822
Query: 3468 AHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK--- 3524
G+A + L +Q +P N +T + V G + C G P P VTW K
Sbjct: 1823 VSNVAGEAVRTFTLTVQ-VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRM 1881
Query: 3525 -VGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI---SM 3580
V G+V GG ++++ ++ A AG Y C A N + ++ V P+I +
Sbjct: 1882 PVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGV 1941
Query: 3581 PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGS-----LPPDSR--LENNMLMLPSVRP 3633
+E V G C A G P PD++W K DGS + P R L+ L+L +R
Sbjct: 1942 AREHHVLEGQEVRLDCEADGQPPPDVAWLK-DGSPLGQDMGPHLRFYLDGGSLVLKGLRA 2000
Query: 3634 QDAGTYVCTATNRQGK 3649
DAG Y C A N G+
Sbjct: 2001 SDAGAYTCVAHNPAGE 2016
Score = 436 bits (1122), Expect = e-121
Identities = 501/1875 (26%), Positives = 729/1875 (38%), Gaps = 258/1875 (13%)
Query: 1685 RSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAG 1742
R IV ++ L C + PP W RED +P+ +G + G L P V+ +AG
Sbjct: 1478 REIVENNPAY-LYCDTNAIPPPDLTWYRED-QPLSAGDEVSVLQGGRVLQIPLVRAENAG 1535
Query: 1743 VYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAY 1802
Y C N + ELLV P + T E +V + V+ C A +P
Sbjct: 1536 RYSCKASNEVGEDWLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALG-NPVP 1593
Query: 1803 TLVWTRLHNGKLP------TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLH 1856
T+ W L NG LP + ++ +L + +++DA +Y+C N + TL
Sbjct: 1594 TISW--LQNG-LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1650
Query: 1857 VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW--------TGGPGGQLP 1908
VQ + + + Q+T C P P + W G LP
Sbjct: 1651 VQ----VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP 1706
Query: 1909 AKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQ-- 1966
+ G RL +D Y C A ++AG+ L V P + +P Q
Sbjct: 1707 GTHTLQLGRARL-----SDSGMYTCEALNAAGRDQKLVQLSVLVP--PAFRQAPRGPQDA 1759
Query: 1967 --VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT----LLIPAITTADA 2020
V G L C +P T+TW K+G P ++RT L I +D
Sbjct: 1760 VLVRVGDKAVLSCETDALPEPTVTWYKDG---QPLVLAQRTQALRGGQRLEIQEAQVSDK 1816
Query: 2021 GFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080
G Y C ++ AG A + V P ++ + S G L L C V+G
Sbjct: 1817 GLYSCKVSNVAGEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCDVSGVPAP 1872
Query: 2081 QVTWYRRGGSLPPHTQ-VHG-----SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
VTW + +P + VHG RL+L ++ PA +G Y C EN V+V
Sbjct: 1873 TVTWLK--DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAV 1930
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194
L S G R HV EGQ + L+C GQ V W K G L
Sbjct: 1931 LVAPRIRSS-----GVAR-------EHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ 1978
Query: 2195 RHQTH------GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVR 2248
H G L L + +D+G Y C +G E + L T+ ++P I
Sbjct: 1979 DMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG--EDARLHTVNV-LVPPTIKQGA 2035
Query: 2249 IESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV----RGSRLYIFQASPA 2304
S + G+ + + C V G V+W K G LP + G L I + A
Sbjct: 2036 DGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLA 2095
Query: 2305 DAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQ----VAEGQTLDL 2360
DAG + C + + G N P +EP Q V G ++L
Sbjct: 2096 DAGIFTC---------VAASPAGVADRNFTLQV--QVPPVLEPVEFQNDVVVVRGSLVEL 2144
Query: 2361 NCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASV 2420
C G V+W K G L + G L+L DSG Y C + +
Sbjct: 2145 PCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHF 2204
Query: 2421 LVT------IEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG 2474
+T IE +G L +TP G ++L C G +TWHK G
Sbjct: 2205 QLTVMEPPHIEDSGQPTELSLTP-------------GAPMELLCDAQGTPQPNITWHKDG 2251
Query: 2475 GSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAY 2534
+L R + + R+L+V D+G Y C +G E S V +Q + +G +
Sbjct: 2252 QAL-TRLENNSRATRVLRVR--DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRF 2308
Query: 2535 PVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP----SRHQIVGSRLRIPQV 2590
V LA G L L C V ++ ITW++ G L ++ G L++ +
Sbjct: 2309 VV-------GLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQAL 2360
Query: 2591 TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLN 2650
+ ADSG+Y C N AGS + V I P IR + V QT L
Sbjct: 2361 STADSGDYSCTARNAAGSTSVAFRVEIH---------TVPTIRSGPPAVNVSVNQTALLP 2411
Query: 2651 CVVARQPQAIITWYKRGGSLPSRHQT-----HGSHLRLHQMSVADSGEYVCRANNNIDAL 2705
C P +++W K L R GS LR+ + D+G Y+C A+N+ +
Sbjct: 2412 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2470
Query: 2706 EASIVISV-SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRG 2764
+ V P A +PS ++ + L C G V W K G
Sbjct: 2471 RQGRDLRVLEPPAIAPSPSNLTLTAHTPAL-----------LPCEASGSPKPLVVWWKDG 2519
Query: 2765 GSLPSHHQTRGSRLR------LHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAV 2818
L Q RL L P DS ++ C V G VT V
Sbjct: 2520 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVT--------V 2571
Query: 2819 HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH---- 2874
HVP P I + + V + L C G V+W K G L AR +
Sbjct: 2572 HVP-----PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP 2626
Query: 2875 GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 2934
L + Q P +G Y+C S+G V +T++ +SP P P + +
Sbjct: 2627 SGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ-ASPVVKPLPSVVRA-------- 2677
Query: 2935 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH---GSQLRLHLVSPADSGEYVC 2991
V E + L L C G +TW K G ++ T G QLR+ SP D+G Y+C
Sbjct: 2678 -VAEEEVL-LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 2735
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
A + G + V P PVI P + +G A C P
Sbjct: 2736 IAKNSAGSAMGKTRLVVQVP----------PVIENGLPDLSTTEGSHAFLPCKARGSPEP 2785
Query: 3052 ISLEWKTRNQEL---EDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV 3108
++ W Q + E I P+G ++ + + GTY C A NA G A+ V+L++
Sbjct: 2786 -NITWDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2843
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGL--MDS 3166
P + LP G +++G + L C + G P WT ++ P T G+ D
Sbjct: 2844 LVLPVFTTLP-GDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-----TEGVSEQDG 2896
Query: 3167 HAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE-A 3225
+ LQ ++ D+GTYVC A+N +G Q V V AP +Q E VE
Sbjct: 2897 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE------APVLQGEAFSYLVEPV 2950
Query: 3226 GHTATLRCSATGSPAPTIHWSKLRSPLPW---QHRLEGDTLIIPRVAQQDSGQYICNATS 3282
G + L C G P P IHW K PL +H+L+ +L I R + D+G+Y C A +
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIRRTERDDAGRYQCLAEN 3010
Query: 3283 PAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR 3342
G A+ +IL ++S P P+ +V++G+ V L+C A G P T +W + G P R
Sbjct: 3011 EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ--PLR 3068
Query: 3343 ATAR-----NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP----GSLPATS 3393
A+ R + L E D+G Y C N +GSA A A L+V+G P GS+ T
Sbjct: 3069 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSM--TG 3126
Query: 3394 IPAG---STPTVQVTPQLETKSIGASVEFHCA-VPSDRGTQLR----------W--FKEG 3437
+ G T+ + E S +S+ VP++ G +R W +E
Sbjct: 3127 VINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHVPANVGPLMRVLVVTIAPIYWALARES 3186
Query: 3438 GQLPPGHSVQDGVLR 3452
G+ GHS+ G R
Sbjct: 3187 GEALNGHSLTGGRFR 3201
Score = 426 bits (1096), Expect = e-118
Identities = 542/2117 (25%), Positives = 783/2117 (36%), Gaps = 296/2117 (13%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQ--GSELHFPSVQPSDAGVYICTCRNLH 1752
+L C G P W E G PV + R + GS L S + +G+Y C
Sbjct: 333 ALECVARGHPSPTLSWHHE-GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA---- 387
Query: 1753 QSNTSRAELLVTEAPSKPITVTVEEQRSQ-SVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
S A L + P + V E Q + G + C A S SP T+ W L N
Sbjct: 388 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQW--LQN 444
Query: 1812 GKLPTRAMDFNGI--------LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS--- 1860
G+ A + G+ L I +V+L +G + C +N + GTA V+ S
Sbjct: 445 GR---PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN----EAGTAGAEVEVSVHG 497
Query: 1861 ----GTLSAPVVSIH--------------PPQLTVQPGQLAEFRCSAT-GSPTPTLEWTG 1901
G L P+ H PP V G A + G +P W G
Sbjct: 498 EWAPGVLEVPIGQYHWGXEHHSSFPAACDPP---VHRGWGAHPKPPLVEGWCSPGSLW-G 553
Query: 1902 GPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVS 1961
P G +P + L++ V+ D+ Y C A + AG+ L V P ++
Sbjct: 554 EPTG-IPVAYSLPPP-LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP--PNIEPG 609
Query: 1962 PERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIATLLIPAITTA 2018
P V +V L C A+GVP ++W K G P + T D L I +
Sbjct: 610 PVNKAVLENASVTLECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLS 667
Query: 2019 DAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPS-VTEGQTLDLNCVVAGS 2077
DAG Y CVA++ AG+ + R + V PP + + S P V + L C G+
Sbjct: 668 DAGSYRCVASNVAGSTELRYGLRV-----NVPPRITLPPSLPGPVLVNTPVRLTCNATGA 722
Query: 2078 AHAQVTWYRRGGSLPPH----TQVH--GSRLRLPQVSPADSGEYVCRVENGSGPKEASIT 2131
+ W + G + P QV G L L +DSG Y C + G +
Sbjct: 723 PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 782
Query: 2132 VSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGS 2191
+ V H PS I E + V +++ L C ++W K G
Sbjct: 783 LQV----HMPPS----------ILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRP 828
Query: 2192 LPARHQTHGS----LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
L R H S LL++ + D+G Y C + +G E + + + P+ P+
Sbjct: 829 LEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVA----PVFPL 884
Query: 2248 RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH------QVRGSRLYIFQA 2301
R ES + TV EG LSC G +++W K G LP G LY+ QA
Sbjct: 885 R-ESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 943
Query: 2302 SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPI---RIEPSSSQVAEGQTL 2358
A G Y C SN V G +L I R P+ V +
Sbjct: 944 QLAQEGTYTCECSN---------VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 994
Query: 2359 DLNCVVPGQSHAQVTWHKRG----GSLPVRHQTHGSLLRLYQASPADSGEYVC---RVLG 2411
L C G+ VTW + G L ++ Q G L + +A A +G Y C + G
Sbjct: 995 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 1054
Query: 2412 SSV-PLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTW 2470
+ E SVLV E G + L ++ A L L C G + W
Sbjct: 1055 RAERKFELSVLVPPELIGDLDPL----------TNITAALHSPLTLLCEAMGIPPPAIRW 1104
Query: 2471 HKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSG 2526
+ + + G L++ Q DSG Y C +G + V
Sbjct: 1105 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE------- 1157
Query: 2527 SHSQGVAYPVRIESSSAS----LANGHTLDLNCLVASQAPHTITWYKRGGSLP--SRHQI 2580
V P IE+ + +G T L C V +TW+K G L H I
Sbjct: 1158 -----VLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHI 1212
Query: 2581 V--GSRLRIPQVTPADSGEYVCHVSNGAGSR------ETSLIVTIQGSGSSHVPSVSPPI 2632
G L++ Q + +G Y C +N G + L TI G
Sbjct: 1213 SPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA------- 1265
Query: 2633 RIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQ------THGSHLRLHQM 2686
TV + L C P ITW K G + THG L++
Sbjct: 1266 ---DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNA 1320
Query: 2687 SVADSGEYVCRANNNIDAL----EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGE 2742
D+G+Y C N + ++I S S P A ++ + +S
Sbjct: 1321 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNS------- 1373
Query: 2743 TLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR----GSRLRLHHVSPADSGEYVCRVMGS 2798
TL L C + W+K G + + + G L++ +DSG Y+C
Sbjct: 1374 TLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNV 1433
Query: 2799 SGPLEASVLVTIEASG--------SSAVHV-----PAPGGAPPIRIEPSSSRVAEGQTLD 2845
+G + V I+ S+A + A GG R + E
Sbjct: 1434 AGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR------EIVENNPAY 1487
Query: 2846 LKCVVPGQAHAQVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGT 2901
L C +TW++ L A +V G +L++ V ++G YSC+ + G
Sbjct: 1488 LYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGE 1547
Query: 2902 --LEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWY 2959
L +LV P G L + + + ASS T+ L C G ++W
Sbjct: 1548 DWLHYELLVLTPPVILGDTEE--LVEEVTVNASS-------TVSLQCPALGNPVPTISWL 1598
Query: 2960 KRG--GSLPARHQT--HGSQLRLHLVSPADSGEYVCRAASGPGPEQEA-SFTVTVPPSEG 3014
+ G S R Q G L++ AD+ Y+C A + G ++ + V VPP
Sbjct: 1599 QNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR-- 1656
Query: 3015 SSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELE--DNVHISPN 3072
+ +D T S C +H P + W +Q L + V + P
Sbjct: 1657 --------IAGLDLEQVTAILNSSVSLPCDVHAHPNP-EVTWYKDSQALSLGEEVFLLPG 1707
Query: 3073 GSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP---VWVKVGKA 3129
+ + R S+ G Y C A NA G Q +V LSV PP P GP V V+VG
Sbjct: 1708 THTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDK 1767
Query: 3130 VTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQN 3189
L C + P + W + P L QRT L L+I A+ SD G Y C N
Sbjct: 1768 AVLSCETDALPEPTVTWYK-DGQPLVLAQRTQALRGGQR-LEIQEAQVSDKGLYSCKVSN 1825
Query: 3190 ALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE-AGHTATLRCSATGSPAPTIHWSKL 3248
G A + + V P + + E + AG L C +G PAPT+ W K
Sbjct: 1826 VAGEAVRTFTLTVQV------PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKD 1879
Query: 3249 RSPLPWQ--HRL--EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY--AT 3302
R P+ H + G L + R+ +G Y C A + A ++ V P ++
Sbjct: 1880 RMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSS 1939
Query: 3303 TVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAA 3356
V V G+ V+L C A G PP W + GS L R L +
Sbjct: 1940 GVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLR 1999
Query: 3357 PEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGAS 3416
D+G Y C N G + V PP A + T+ P G
Sbjct: 2000 ASDAGAYTCVAHNPAGEDARLHTVNVLVPP----TIKQGADGSGTLVSRP-------GEL 2048
Query: 3417 VEFHCAVPSDRGTQLRWFKEGGQLPPGHSV----QDGVLRIQNLDQSCQGTYICQAHGPW 3472
V C V + W K+G LP LRI + + G + C A P
Sbjct: 2049 VTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPA 2108
Query: 3473 GKAQASAQLVIQALPSVLINIRTSVQTVVV-GHAVEFECLALGDPKPQVTWSKVGGHLRP 3531
G A + L +Q +P VL + VVV G VE C A G P P V+W K G L
Sbjct: 2109 GVADRNFTLQVQ-VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLS 2167
Query: 3532 GIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI---SMPQEVRVPA 3588
++ G +++ V D+G Y C A + AG + H L V P I P E+ +
Sbjct: 2168 QSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTP 2227
Query: 3589 GSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQG 3648
G+ C A G P P+I+W K +L +RLENN +R +DAG Y C A + G
Sbjct: 2228 GAPMELLCDAQGTPQPNITWHKDGQAL---TRLENNSRATRVLRVRDAGLYTCLAESPAG 2284
Query: 3649 KV-KAF-AHLQVPERVV 3663
+ K+F +Q P +V
Sbjct: 2285 AIEKSFRVRVQAPPNIV 2301
Score = 372 bits (956), Expect = e-102
Identities = 444/1767 (25%), Positives = 686/1767 (38%), Gaps = 263/1767 (14%)
Query: 2042 VLSASDASPPPVKIESSSPSVT--EGQTLDLNCVVAGSAHAQVTWYRRG----------- 2088
+L+ PP ++ + +V+ GQ+L L C G ++ W +
Sbjct: 8 LLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAG 67
Query: 2089 -------GSLPPHTQV-HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHS 2140
G + H + G L P++ DSG Y CR EN +G + + VL +
Sbjct: 68 YGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVL----T 123
Query: 2141 GPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK-RGGSLPA----R 2195
PS + + + G ++L C G QV W K R LP +
Sbjct: 124 PPSVLGAGAAQEVLGLA--------GADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQ 175
Query: 2196 HQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV---RIESS 2252
Q G +LR+ D G Y C +G + + A PP E+
Sbjct: 176 VQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHA-------PPTIWGSNETG 228
Query: 2253 SSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV---RGSR-LYIFQASPADAGQ 2308
V E + L C G +TW+K G LP +V RG R L + +A +DAG
Sbjct: 229 EVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGV 288
Query: 2309 YVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQS 2368
Y C+ASN + A+ T AG P + G+ + L CV G
Sbjct: 289 YTCKASNAVGAAEKATRLDVYVPPTIEGAGG------RPYVVKAVAGRPVALECVARGHP 342
Query: 2369 HAQVTWHKRGGSLPV------RHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLV 2422
++WH G LPV R +T GS+LRL A SG Y C + SS EA +
Sbjct: 343 SPTLSWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSC--VASSPAGEAVLQY 398
Query: 2423 TIEPAGSVPALGVTPTVRIESSSSQVAE--GQTLDLNCLVAGQAHAQVTWHKRGGSLPAR 2480
++E + V P + + QV GQ L+L C +G + W + G PA
Sbjct: 399 SVE-------VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNG--RPAE 449
Query: 2481 HQV------HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGV-- 2532
G+ L + V SG + C+ +GT A V V++ G + GV
Sbjct: 450 ELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH----GEWAPGVLE 505
Query: 2533 ----AYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL---PSRHQIVGS-- 2583
Y E S+ A A P + + GSL P+ + S
Sbjct: 506 VPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLP 565
Query: 2584 -RLRIPQVTPADSGEYVCHVSNGAG--SRETSLIVTIQGSGSSHVPSVSP-PIRIESSSP 2639
L+I +V D G Y C +N AG RE +L V + P++ P P+ +
Sbjct: 566 PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP-------PNIEPGPV-----NK 613
Query: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS----RHQTHGSHLRLHQMSVADSGEYV 2695
V+E ++ L C+ + P ++W+K + S G LR+ Q ++D+G Y
Sbjct: 614 AVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYR 673
Query: 2696 CRANNNIDALEA--SIVISVSPSAG-SPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPG 2752
C A+N + E + ++V P PS PG P+ + + + L C G
Sbjct: 674 CVASNVAGSTELRYGLRVNVPPRITLPPSLPG---PVLVNT---------PVRLTCNATG 721
Query: 2753 QAHAQVTWHKRGGSL-----PSHHQTRGSR-LRLHHVSPADSGEYVCRVMGSSGPLEASV 2806
+ W K G + P G R L L +DSG Y C + + G V
Sbjct: 722 APSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDV 781
Query: 2807 LVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGN 2866
++ VH+P P I E + V +++ L+C ++W K G
Sbjct: 782 VL--------QVHMP-----PSILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRP 828
Query: 2867 LPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPG 2922
L R VH LL++++ D+G Y+C+ +G E + + + P+
Sbjct: 829 LEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGHSEKHYNLNVWVAPVFPLR--- 885
Query: 2923 LAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARH------QTHGSQL 2976
E+ + V EG L+C G +++W K G LP G L
Sbjct: 886 -------ESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLL 938
Query: 2977 RLHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQ 3035
L A G Y C ++ G Q+ V VPP R P P +V Q
Sbjct: 939 YLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP---REP-----PTQVSVVQ 990
Query: 3036 GQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNGSIITIVGTRPSNHGTYRCVA 3093
A+ +C G P ++ W+ Q + E + + G + + + ++ G Y CVA
Sbjct: 991 DGVATLECNA-TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVA 1049
Query: 3094 SNAYGVAQSVVNLSVHGPPTV--SVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISS 3151
N G A+ LSV PP + + P + + +TL C + G P + RW R
Sbjct: 1050 ENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR-GE 1108
Query: 3152 TPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK--QVEVIVDTGAMAP 3209
P + TY L+ +L+++ + D+G Y CLA N G A++ VEV+V
Sbjct: 1109 EPVSPGEDTY-LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVLV------- 1160
Query: 3210 GAPQVQAEEAELTVEA--GHTATLRCSATGSPAPTIHWSKLRSPLPW--QHRLEGDTLII 3265
P ++ E+ E ++ G TA L C+ TG P P + W K PL H + D +++
Sbjct: 1161 -PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLL 1219
Query: 3266 P--RVAQQDSGQYICNATSPAGHAEATIILHVESPP-----YATTVPEHASVQAGETVQL 3318
+ +G Y C A + G L V P + E +V + L
Sbjct: 1220 QVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISL 1279
Query: 3319 QCLAHGTPPLTFQWSRVGSSLPGRATARNEL------LHFERAAPEDSGRYRCRVTNKVG 3372
C A P W + G+ P A+ +L L A ED+G+Y C VTN++G
Sbjct: 1280 ICEALAFPSPNITWMKDGA--PFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELG 1337
Query: 3373 SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLR 3432
A + V PP + P +V + + +++ C + +R
Sbjct: 1338 EAVKNYHVEVLIPPSI-------SKDDPLAEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1390
Query: 3433 WFKEGGQLPPGHSVQ----DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALP- 3487
W+K+G + P +Q +L+IQ S G Y+C A G+ ++IQ P
Sbjct: 1391 WYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPM 1450
Query: 3488 -------SVLINIR----------TSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLR 3530
S I T + +V + C P P +TW + L
Sbjct: 1451 FQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLS 1510
Query: 3531 PG----IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI-----SMP 3581
G ++Q G V++I V +AG+Y C A+N G H LLV P I +
Sbjct: 1511 AGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELV 1570
Query: 3582 QEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL----ENNMLMLPSVRPQDAG 3637
+EV V A S C A G P P ISW + P RL + +L + + DA
Sbjct: 1571 EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAA 1630
Query: 3638 TYVCTATNRQGKVKAF--AHLQVPERV 3662
+Y+C A N+ G + +QVP R+
Sbjct: 1631 SYMCVAENQAGSAEKLFTLRVQVPPRI 1657
Score = 187 bits (476), Expect = 2e-46
Identities = 178/607 (29%), Positives = 243/607 (40%), Gaps = 100/607 (16%)
Query: 3127 GKAVTLECVSAGEPRSSARWTRISS-TPAKLEQRTYG------------LMDSHAVLQIS 3173
G+++TLEC + G P W + + L YG L+D L
Sbjct: 33 GQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFP 92
Query: 3174 SAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRC 3233
+ D+G Y C A+N GTAQ+ ++V T GA Q E+ AG L+C
Sbjct: 93 RIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQ----EVLGLAGADVELQC 148
Query: 3234 SATGSPAPTIHWSKLRSP-LPWQHRLE----GDTLIIPRVAQQDSGQYICNATSPAGHAE 3288
+G P P + W+K R P LP L+ G L I D G+Y C A SPAG
Sbjct: 149 WTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQA 208
Query: 3289 ATIILHVESPP--YATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA--- 3343
L V +PP + + +V VQL C A G P W + G+ LP
Sbjct: 209 RDFQLRVHAPPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVV 268
Query: 3344 -TARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTV 3402
T L RA D+G Y C+ +N VG+AE +L V PP T AG P V
Sbjct: 269 YTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPP-----TIEGAGGRPYV 323
Query: 3403 QVTPQLETKSI-GASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ-----DG-VLRIQN 3455
K++ G V C L W EG LP S + DG VLR+++
Sbjct: 324 -------VKAVAGRPVALECVARGHPSPTLSWHHEG--LPVAESNESRLETDGSVLRLES 374
Query: 3456 LDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGD 3515
++ G Y C A P G+A + +Q P +L+ T +VG +E C A G
Sbjct: 375 PGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGS 434
Query: 3516 PKPQVTWSKVGGHLRPG-------IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHV 3568
P P + W + G RP + G + I HVEL +G + C ATN AGT + V
Sbjct: 435 PVPTIQWLQNG---RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEV 491
Query: 3569 LLLVQALPQISMPQEVRVPAG------------------------SAAVFPCIASGYPTP 3604
+ V P + VP G A P + G+ +P
Sbjct: 492 EVSVHG---EWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSP 548
Query: 3605 DISWSKLDG-----SLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQ-- 3657
W + G SLPP ++E V +D G Y C ATN G+ K L+
Sbjct: 549 GSLWGEPTGIPVAYSLPPPLQIE-------KVDLRDEGIYTCAATNLAGESKREVALKVL 601
Query: 3658 VPERVVP 3664
VP + P
Sbjct: 602 VPPNIEP 608
Score = 158 bits (400), Expect = 1e-37
Identities = 140/516 (27%), Positives = 205/516 (39%), Gaps = 58/516 (11%)
Query: 3199 EVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSPLPW 3254
E +++TG++ P + + +A ++ AG + TL C A G P P I W K + PL W
Sbjct: 6 EPLLNTGSVVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGW 65
Query: 3255 Q-------------HRL--EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPP 3299
HRL EG +L PR+ + DSG Y C A + AG A+ L V +PP
Sbjct: 66 AGYGWDLGWGQVGGHRLLDEGQSLHFPRIQEGDSGLYSCRAENQAGTAQRDFHLLVLTPP 125
Query: 3300 --YATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSS-LPG----RATARNELLHF 3352
+ AG V+LQC G P +W++ LPG + ++L
Sbjct: 126 SVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRI 185
Query: 3353 ERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKS 3412
+ D GRY+C + G QL V PP GS T +V +
Sbjct: 186 TGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW-------GSNETGEVAVMED--- 235
Query: 3413 IGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV----QDGVLRIQNLDQSCQGTYICQA 3468
V+ C + WFK+G LP V L++ S G Y C+A
Sbjct: 236 --HLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKA 293
Query: 3469 HGPWGKAQASAQLVIQALPSVL-INIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGG 3527
G A+ + +L + P++ R V V G V EC+A G P P ++W G
Sbjct: 294 SNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGL 353
Query: 3528 HLRPG----IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ- 3582
+ + G V+R+ A +G Y C A++ AG + VQ PQ+ + +
Sbjct: 354 PVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQLLVAEG 413
Query: 3583 --EVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDS------RLENNMLMLPSVRPQ 3634
+V G PC ASG P P I W L P + + L + V
Sbjct: 414 LGQVTTIVGQPLELPCQASGSPVPTIQW--LQNGRPAEELAGVQVASQGTTLHIDHVELD 471
Query: 3635 DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTP 3670
+G + C ATN G A + V P + P
Sbjct: 472 HSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP 507
Score = 51.6 bits (122), Expect = 2e-05
Identities = 37/115 (32%), Positives = 49/115 (42%), Gaps = 4/115 (3%)
Query: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVK 470
PP ++ S QT C A GVP P+++WR + +P PR G+L I+ V
Sbjct: 2397 PP--AVNVSVNQTALLPCQADGVPAPLVSWRKD--RVPLDPRSPRFEILPEGSLRIQPVL 2452
Query: 471 ESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFG 525
D G Y C A N+ G D + P P P H+ A LPC G
Sbjct: 2453 AQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASG 2507
Score = 48.1 bits (113), Expect = 2e-04
Identities = 32/95 (33%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 1674 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRH-QGSELH 1732
Q+ V +V P V G +LRCQ +G P W + G+P+ + + R L
Sbjct: 3024 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRASRRLRTLPDGSLW 3082
Query: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP 1767
+V+ DAG Y C NL S T+RA L+V P
Sbjct: 3083 LENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3117
Score = 45.1 bits (105), Expect = 0.002
Identities = 27/63 (42%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 424 VTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMN 483
V C A GVPTP I W + +P+ +V T GGR L + + SD G YTC+A N
Sbjct: 238 VQLLCEARGVPTPNITWFKDGALLPTSTKVVYT-RGGR-QLQLGRAQSSDAGVYTCKASN 295
Query: 484 ARG 486
A G
Sbjct: 296 AVG 298
Score = 45.1 bits (105), Expect = 0.002
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 2/82 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP P E++ G + TC GVP P + W + + S V S GGR
Sbjct: 1840 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGR-- 1897
Query: 464 LIIRDVKESDQGAYTCEAMNAR 485
L + ++ + G YTC A N +
Sbjct: 1898 LQLSRLQPAQAGTYTCVAENTQ 1919
Score = 42.0 bits (97), Expect = 0.013
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP + P +VT C+A GVP P ++W + S VTV+ +G
Sbjct: 602 VPPNIEPGPVNKAVLENA-SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG--RV 658
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L I + SD G+Y C A N G
Sbjct: 659 LRIEQAQLSDAGSYRCVASNVAG 681
Score = 42.0 bits (97), Expect = 0.013
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 4/85 (4%)
Query: 404 MPPQVV--TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR 461
+PP+++ P +I A+ +T C A+G+P P I W G P P G
Sbjct: 1066 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLAGG 1123
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
L + +E D G Y+C A N G
Sbjct: 1124 WMLKMTQTQEQDSGLYSCLASNEAG 1148
Score = 40.8 bits (94), Expect = 0.030
Identities = 25/84 (29%), Positives = 38/84 (45%), Gaps = 2/84 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRG 462
+PP++ PP V TC A G P+P + W + + P+ GGR
Sbjct: 693 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR- 751
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
L + + SD G Y+C A++A G
Sbjct: 752 VLTLASARASDSGRYSCVAVSAVG 775
Score = 40.8 bits (94), Expect = 0.030
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 11/88 (12%)
Query: 408 VVTPPR---------ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSE 458
V+TPP E + + TV+ C A+G P P I+W N PR+ V +
Sbjct: 1556 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1615
Query: 459 GGRGTLIIRDVKESDQGAYTCEAMNARG 486
G L + + +D +Y C A N G
Sbjct: 1616 G--QVLQVSTAEVADAASYMCVAENQAG 1641
Score = 40.0 bits (92), Expect = 0.051
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 384 ASFHCDEESDCPDRSDEFGC---MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINW 440
AS+ C E+ F +PP++ E + A +V+ C P P + W
Sbjct: 1630 ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW 1689
Query: 441 RLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ + V + G TL + + SD G YTCEA+NA G
Sbjct: 1690 YKDSQALSLGEEVFLLP--GTHTLQLGRARLSDSGMYTCEALNAAG 1733
Score = 40.0 bits (92), Expect = 0.051
Identities = 39/135 (28%), Positives = 54/135 (40%), Gaps = 5/135 (3%)
Query: 405 PPQVVTP--PRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
PP +V P PR + + GQ V C P P I W + G + T E GR
Sbjct: 2297 PPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHRD-GIVLQEDAHTQFPERGR- 2353
Query: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCF 522
L ++ + +D G Y+C A NA G + VP P + A LPC
Sbjct: 2354 FLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQ 2413
Query: 523 CFGITSVCQSTRRFR 537
G+ + S R+ R
Sbjct: 2414 ADGVPAPLVSWRKDR 2428
Score = 39.7 bits (91), Expect = 0.067
Identities = 23/68 (33%), Positives = 34/68 (50%), Gaps = 4/68 (5%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSH--PRVTVTSEGGRGTLIIRDVKESDQGAYT 478
GQ V C A G P P + W + + P + +GG +L+++ ++ SD GAYT
Sbjct: 1950 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYT 2007
Query: 479 CEAMNARG 486
C A N G
Sbjct: 2008 CVAHNPAG 2015
Score = 38.9 bits (89), Expect = 0.11
Identities = 28/102 (27%), Positives = 41/102 (40%), Gaps = 24/102 (23%)
Query: 404 MPPQVVTPPRES-IQASRGQTVTFTCVAIGVPTPII------------------NWRLNW 444
+PP + R++ + GQ++T C A G P P I W L W
Sbjct: 15 VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLGWAGYGWDLGW 74
Query: 445 GHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
G + H + EG +L ++E D G Y+C A N G
Sbjct: 75 GQVGGH---RLLDEG--QSLHFPRIQEGDSGLYSCRAENQAG 111
Score = 38.9 bits (89), Expect = 0.11
Identities = 34/115 (29%), Positives = 46/115 (40%), Gaps = 5/115 (4%)
Query: 408 VVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIR 467
VV P ++A + V C A G+P P I W+ ++ + V G L I
Sbjct: 2667 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP---GGQLRIA 2723
Query: 468 DVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQ-RGPCPDGHFYLEHSAACLPC 521
D G Y C A N+ G G V+++ P PD E S A LPC
Sbjct: 2724 HASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPC 2777
Score = 38.1 bits (87), Expect = 0.19
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
+ ++ T+T C + VP P I W + + R+ V EG L I+ + SD
Sbjct: 1365 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVSD 1422
Query: 474 QGAYTCEAMNARG 486
G Y C A N G
Sbjct: 1423 SGRYLCVATNVAG 1435
Score = 37.7 bits (86), Expect = 0.25
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 8/93 (8%)
Query: 396 DRSDEFGCMPPQVVTPP--RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRV 453
DR+ P V+ P + + RG V C A GVP P+++W + P +
Sbjct: 2112 DRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD-----GEPLL 2166
Query: 454 TVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ + E G +L + V D G Y+C A++ G
Sbjct: 2167 SQSLEQG-PSLQLEAVGAGDSGTYSCVAVSEAG 2198
Score = 37.4 bits (85), Expect = 0.33
Identities = 27/84 (32%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Query: 404 MPPQV-VTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
+PPQ+ V + GQ + C A G P P I W N V V S+G
Sbjct: 404 VPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG--T 461
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
TL I V+ G + C+A N G
Sbjct: 462 TLHIDHVELDHSGLFACQATNEAG 485
Score = 37.4 bits (85), Expect = 0.33
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
MPP ++ ++ ++V C + +P P+++W + P PR V +
Sbjct: 787 MPPSILGEEL-NVSVVANESVALECQSHAMPPPVLSWWKDGR--PLEPRPGVHLSADKAL 843
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L + D G YTCEA+N G
Sbjct: 844 LQVDRADVWDAGHYTCEALNQAG 866
Score = 36.2 bits (82), Expect = 0.74
Identities = 26/81 (32%), Positives = 36/81 (44%), Gaps = 4/81 (4%)
Query: 409 VTPPRES--IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSH-PRVTVTSEGGRGTLI 465
V P RES + G +C GVP P I+WR + +P + S GR L
Sbjct: 881 VFPLRESHTLTVREGHPTRLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR-LLY 939
Query: 466 IRDVKESDQGAYTCEAMNARG 486
+ + + +G YTCE N G
Sbjct: 940 LGQAQLAQEGTYTCECSNVVG 960
Score = 36.2 bits (82), Expect = 0.74
Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 4/82 (4%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRGTL 464
P V+ + + G C A G P P I W + + + + T+ G L
Sbjct: 2755 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG---EL 2811
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
++++++ D G YTC A NA G
Sbjct: 2812 LVKNLEGQDAGTYTCTAENAVG 2833
Score = 36.2 bits (82), Expect = 0.74
Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 3/66 (4%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G V C A G PTP I W + + R+ + G+L + +V+ D G Y C
Sbjct: 3041 GDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD---GSLWLENVETGDAGTYDCV 3097
Query: 481 AMNARG 486
A N G
Sbjct: 3098 AHNLLG 3103
Score = 35.4 bits (80), Expect = 1.3
Identities = 27/121 (22%), Positives = 41/121 (33%), Gaps = 2/121 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P + + + V TC + G+P P ++W + + S G L
Sbjct: 2574 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSG--ALE 2631
Query: 466 IRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFG 525
I G YTC A N+ G+ ++ P P P + LPC G
Sbjct: 2632 IGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASG 2691
Query: 526 I 526
I
Sbjct: 2692 I 2692
Score = 35.4 bits (80), Expect = 1.3
Identities = 22/66 (33%), Positives = 27/66 (40%), Gaps = 4/66 (6%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G + C A G PTP I W +N + V+ + G TL V D G Y C
Sbjct: 2861 GDRLWLRCAARGSPTPRIGWTVNDRPVTE----GVSEQDGGSTLQRAAVSREDSGTYVCW 2916
Query: 481 AMNARG 486
A N G
Sbjct: 2917 AENRVG 2922
Score = 35.0 bits (79), Expect = 1.6
Identities = 28/109 (25%), Positives = 42/109 (38%), Gaps = 13/109 (11%)
Query: 386 FHCDEESDCPDRSDEFGCMPPQVVTPPR-------ESIQASRGQTVTFTCVAIGVPTPII 438
+ C E+ +F + V+TPP + + G V C GVPTP +
Sbjct: 102 YSCRAENQAGTAQRDFHLL---VLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQV 158
Query: 439 NWRLNWGHI-PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
W + + P P + V +G L I D+G Y C A + G
Sbjct: 159 EWTKDRQPVLPGGPHLQVQEDG--QVLRITGSHVGDEGRYQCVAFSPAG 205
Score = 35.0 bits (79), Expect = 1.6
Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 4/85 (4%)
Query: 404 MPPQVVTPPRESIQASRGQ--TVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR 461
+PPQ+ P Q S Q T C A G P P + W + + + + + ++G
Sbjct: 972 VPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG-- 1029
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
+L + + + G Y+C A N G
Sbjct: 1030 QSLHVERAQAAHTGRYSCVAENLAG 1054
Score = 35.0 bits (79), Expect = 1.6
Identities = 21/86 (24%), Positives = 37/86 (43%), Gaps = 5/86 (5%)
Query: 404 MPP---QVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG 460
+PP Q P++++ G +C +P P + W + + R G
Sbjct: 1745 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1804
Query: 461 RGTLIIRDVKESDQGAYTCEAMNARG 486
R L I++ + SD+G Y+C+ N G
Sbjct: 1805 R--LEIQEAQVSDKGLYSCKVSNVAG 1828
Score = 34.7 bits (78), Expect = 2.1
Identities = 21/59 (35%), Positives = 28/59 (47%), Gaps = 8/59 (13%)
Query: 3848 CRDRP-CQNGGQCHDSESSSYVCVCPAGF----TGSRCEHSQALHCHPEACGPDATCVN 3901
CR R CQ+ C ++E S Y C+CPAG+ +G C+ CGP C N
Sbjct: 3591 CRVRNLCQHA--CRNTEGS-YQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFN 3646
Score = 33.5 bits (75), Expect = 4.8
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRGTLIIRDVKESDQGAYTC 479
G ++ CV G P P I+W + + SH R + + G+L IR + D G Y C
Sbjct: 2951 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQN----GSLTIRRTERDDAGRYQC 3006
Query: 480 EAMNARGMVFGIPDGVLELVP 500
A N G+ + VL+ P
Sbjct: 3007 LAENEMGVAKKVVILVLQSAP 3027
Score = 32.7 bits (73), Expect = 8.2
Identities = 18/71 (25%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
++A G+ V CVA G P+P ++W + + ++G L + E+ G
Sbjct: 324 VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG--SVLRLESPGEASSG 381
Query: 476 AYTCEAMNARG 486
Y+C A + G
Sbjct: 382 LYSCVASSPAG 392
>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
Length = 3874
Score = 517 bits (1332), Expect = e-146
Identities = 538/2081 (25%), Positives = 820/2081 (39%), Gaps = 252/2081 (12%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAGVYI 1745
V G + L C V+G P W + DGRP+ G G L S AG Y
Sbjct: 1266 VLDGQTAHLMCNVTGHPQPKLTWFK-DGRPLARGDAHHISPDGVLLQVLQANLSSAGHYS 1324
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
C N T +L V AP+ +V ++ IC A + P+ +
Sbjct: 1325 CIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNNPISLICEALA-FPSPNIT 1383
Query: 1806 WTR---LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA--- 1859
W + + + L I N Q DAG Y C +N + + HV+
Sbjct: 1384 WMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTN--ELGEAVKNYHVEVLIP 1441
Query: 1860 -SGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPA-KAQI--HG 1915
S + P+ + ++ + C + P PT+ W P+ + Q+ G
Sbjct: 1442 PSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG 1501
Query: 1916 GILRLPAVEPTDQAQYLCRAHSSAGQ--QVARAVLHVH------GGGGPRVQVSPERTQV 1967
+L++ + +D +YLC A + AG+ Q ++ V G ++ +
Sbjct: 1502 RLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEA 1561
Query: 1968 HAGRT----------VRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA----TLLIP 2013
G T LYC +P +TW +E P + + + L IP
Sbjct: 1562 RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYRED---QPLSAGDEVSVLQGGRVLQIP 1618
Query: 2014 AITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTE-----GQTL 2068
+ +AG Y C A++ G +++VL+ PPV + + V E T+
Sbjct: 1619 LVRAENAGRYSCKASNEVGEDWLHYELLVLT------PPVILGDTEELVEEVTVNASSTV 1672
Query: 2069 DLNCVVAGSAHAQVTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSG 2124
L C G+ ++W + G P ++ G L++ AD+ Y+C EN +G
Sbjct: 1673 SLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAG 1732
Query: 2125 PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVT 2184
E T+ V VP + +E ++ + ++ L C V + +VT
Sbjct: 1733 SAEKLFTLRV-----------QVPPRIAGLDLEQVTAIL--NSSVSLPCDVHAHPNPEVT 1779
Query: 2185 WHKRGGSLPARHQ------THGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238
W+K +L + TH L+L + +DSG Y C + +G LV +
Sbjct: 1780 WYKDSQALSLGEEVFLLPGTH--TLQLGRARLSDSGMYTCEALNAAG--RDQKLVQLSVL 1835
Query: 2239 VIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR----GS 2294
V P R + V G LSC VTWYK G L + + G
Sbjct: 1836 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1895
Query: 2295 RLYIFQASPADAGQYVCRASN-GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVA 2353
RL I +A +D G Y C+ SN EA T T+T P T SQVA
Sbjct: 1896 RLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETV--------SQVA 1947
Query: 2354 EGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ------THGSLLRLYQASPADSGEYVC 2407
G L L C V G VTW K +PV + G L+L + PA +G Y C
Sbjct: 1948 -GSPLVLTCDVSGVPAPTVTWLK--DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTC 2004
Query: 2408 RVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQ 2467
+ +V + A + + GV + V EGQ + L+C GQ
Sbjct: 2005 VAENTQAEARKDFVVAVLVAPRIRSSGV-------AREHHVLEGQEVRLDCEADGQPPPD 2057
Query: 2468 VTWHKRGGSLPA------RHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQ 2521
V W K G L R + G L L + +D+G Y C +G E + L T+
Sbjct: 2058 VAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG--EDARLHTVN 2115
Query: 2522 QRLSGSHSQGVAYPVRIESSSASLAN--GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQ 2579
+ + QG S +L + G + + C V P ++W K G LP +
Sbjct: 2116 VLVPPTIKQGA-------DGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQR 2168
Query: 2580 IV----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIE 2635
+ G LRI +V AD+G + C ++ AG + + + +Q VP V P+ +
Sbjct: 2169 TLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQ------VPPVLEPVEFQ 2222
Query: 2636 SSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYV 2695
+ VV G ++L C P +++W K G L S+ G L+L + DSG Y
Sbjct: 2223 NDV-VVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYS 2281
Query: 2696 CRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH 2755
C A + ++V P S P + + G ++L C G
Sbjct: 2282 CVAVSEAGEARRHFQLTVMEP---PHIEDSGQPTELS-----LTPGAPMELLCDAQGTPQ 2333
Query: 2756 AQVTWHKRGGSLPS-HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASG 2814
+TWHK G +L + +R +R+ + D+G Y C +G +E S V ++A
Sbjct: 2334 PNITWHKDGQALTRLENNSRATRV----LRVRDAGLYTCLAESPAGAIEKSFRVRVQA-- 2387
Query: 2815 SSAVHVPAPGGAPPIRIEPSSSR----VAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP-- 2868
PP + P R +A GQ L L+C V + ++TWH+ G L
Sbjct: 2388 ------------PPNIVGPRGPRFVVGLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQED 2434
Query: 2869 --ARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQP 2926
+ G L+L +S ADSG+YSC ++G+ + V I +P P
Sbjct: 2435 AHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT-----VPTIRSGPP 2489
Query: 2927 IYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHG----SQLRLHLVS 2982
+ +V+ QT L C G V+W K L R LR+ V
Sbjct: 2490 ------AVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSLRIQPVL 2543
Query: 2983 PADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFK 3042
D+G Y+C A++ G +++ + P P I+ P + T+ A
Sbjct: 2544 AQDAGHYLCLASNSAGSDRQGRDLRVLEP----------PAIAPSPSNLTLTAHTPALLP 2593
Query: 3043 CLIHDGAAPISLEWKTRNQELEDNVH------ISPNGSIITIVGTRPSNHGTYRCVASNA 3096
C P+ + WK Q+L+ + + N ++T G P + + CV SN
Sbjct: 2594 CEASGSPKPLVVWWKD-GQKLDFRLQQGAYRLLPSNALLLTAPG--PQDSAQFECVVSNE 2650
Query: 3097 YGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKL 3156
G A + ++VH PPT++ + V + V L C S G P + W++ A+L
Sbjct: 2651 VGEAHRLYQVTVHVPPTIAD-DQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAG---AQL 2706
Query: 3157 EQRTYGLMDSHA-VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQ 3215
R G S + L+I A P AG Y C A+N+ G A K V + V + P V
Sbjct: 2707 GARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVV 2766
Query: 3216 AEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSPLPWQHRLEGDTLIIPRVAQQ 3271
AE V L C A+G P PTI W K + + + Q L G L I + +
Sbjct: 2767 RAVAEEEV------LLPCEASGIPRPTITWQKEGLNVATGVSTQV-LPGGQLRIAHASPE 2819
Query: 3272 DSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQ 3331
D+G Y+C A + AG A L V+ PP S G L C A G+P
Sbjct: 2820 DAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPDLSTTEGSHAFLPCKARGSPEPNIT 2879
Query: 3332 WSRVG---SSLPGRATAR--NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP 3386
W + G S G+ T + ELL + +D+G Y C N VG A L +
Sbjct: 2880 WDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRARRRVHLTIL--- 2935
Query: 3387 GSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV 3446
P P + +G + CA ++ W + G S
Sbjct: 2936 -----------VLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVSE 2984
Query: 3447 QDGVLRIQN--LDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGH 3504
QDG +Q + + GTY+C A G+ QA + + ++ P VL S VG
Sbjct: 2985 QDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-VLQGEAFSYLVEPVGG 3043
Query: 3505 AVEFECLALGDPKPQVTWSKVGGHLRPGIVQ---SGGVVRIAHVELADAGQYRCTATNAA 3561
+++ +C+ GDP P + W K G LR ++ G + I E DAG+Y+C A N
Sbjct: 3044 SIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAENEM 3103
Query: 3562 GTTQSHVLLLVQALPQISM-PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR 3620
G + V+L++Q+ P + PQ++ V +G C A+G PTP I W + L R
Sbjct: 3104 GVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQPLRASRR 3163
Query: 3621 LE---NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
L + L L +V DAGTY C A N G A A L V
Sbjct: 3164 LRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVV 3204
Score = 490 bits (1261), Expect = e-137
Identities = 538/2116 (25%), Positives = 814/2116 (38%), Gaps = 270/2116 (12%)
Query: 1683 PARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPS--GTQQRHQGSELHFPSVQPSD 1740
P + V Q G +L C +G PP W R DG+PV + G Q ++QG LH Q +
Sbjct: 1074 PTQVSVVQDGVATLECNATGKPPPTVTWER-DGQPVGAELGLQLQNQGQSLHVERAQAAH 1132
Query: 1741 AGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSP 1800
G Y C NL + EL V P + ++ + + + +T +C A P
Sbjct: 1133 TGRYSCVAENLAGRAERKFELSVLVPPE--LIGDLDPLTNITAALHSPLTLLCEAMGIPP 1190
Query: 1801 AYTLVWTRLHNGKLP---TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV 1857
+ W R P T + +L + Q D+G Y C SN + ++ V
Sbjct: 1191 P-AIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV 1249
Query: 1858 QASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH--- 1914
++ + + V GQ A C+ TG P P L W G+ A+ H
Sbjct: 1250 LVPPSIENEDLE---EVIKVLDGQTAHLMCNVTGHPQPKLTWF--KDGRPLARGDAHHIS 1304
Query: 1915 --GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGG---GPRVQVSPERTQVHA 1969
G +L++ + Y C A ++ G++ L V G + E V
Sbjct: 1305 PDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTV 1364
Query: 1970 GRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT----LLIPAITTADAGFYLC 2025
+ L C A PS ITW K+G P S + L I DAG Y C
Sbjct: 1365 NNPISLICEALAFPSPNITWMKDGA---PFEASRNIQLLPGTHGLQILNAQKEDAGQYTC 1421
Query: 2026 VATSPAGTAQARIQVVVLSASDASP--PPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2083
V T+ G A V VL S P ++ TL L C +
Sbjct: 1422 VVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIR 1481
Query: 2084 WYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTH 2139
WY+ G + P +++ G L++ +DSG Y+C N +G + V +
Sbjct: 1482 WYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI----Q 1537
Query: 2140 SGPSYTPVPGSTRPIRIEPSSSHVAEGQT--------------LDLNCVVPGQAHAQVTW 2185
P + V + I G T D N + P +TW
Sbjct: 1538 VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPP----PDLTW 1593
Query: 2186 HKRGGSLPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGP--LEASVLVTIEASV 2239
++ L A + G +L++ V ++G Y C G L +LV
Sbjct: 1594 YREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT---- 1649
Query: 2240 IPGPIPPVRIESSSSTVAE-----GQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR-- 2292
PPV + + V E T+ L C G ++W + G LP R
Sbjct: 1650 -----PPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNG--LPFSPSPRLQ 1702
Query: 2293 ----GSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPS 2348
G L + A ADA Y+C A N ++ + Q Q I S
Sbjct: 1703 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNS 1762
Query: 2349 SSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ------THGSLLRLYQASPADS 2402
S + L C V + +VTW+K +L + + TH L+L +A +DS
Sbjct: 1763 S--------VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTH--TLQLGRARLSDS 1812
Query: 2403 GEYVCRVLGSSVP----LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC 2458
G Y C L ++ ++ SVLV PA P R + V G L+C
Sbjct: 1813 GMYTCEALNAAGRDQKLVQLSVLVP-------PAFRQAP--RGPQDAVLVRVGDKAVLSC 1863
Query: 2459 LVAGQAHAQVTWHKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCRVVGSSGTQEA 2514
VTW+K G L + G RL + + +D G Y C+V +G
Sbjct: 1864 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1923
Query: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL 2574
+ +T+Q + + + + + S G L L C V+ T+TW K +
Sbjct: 1924 TFTLTVQVPPTFENPK---------TETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPV 1974
Query: 2575 PSR--HQIV--GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
S H +V G RL++ ++ PA +G Y C N +V + V+P
Sbjct: 1975 ESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVL---------VAP 2025
Query: 2631 PIRIESSSPT--VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH------GSHLR 2682
IR + V+EGQ + L+C QP + W K G L H G L
Sbjct: 2026 RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLV 2085
Query: 2683 LHQMSVADSGEYVCRANNNI--DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAE 2740
L + +D+G Y C A+N DA ++ + V P+ A GS +
Sbjct: 2086 LKGLRASDAGAYTCVAHNPAGEDARLHTVNVLVPPTI-KQGADGSGTLVS--------RP 2136
Query: 2741 GETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT----RGSRLRLHHVSPADSGEYVCRVM 2796
GE + + C V G V+W K G LP +T G LR+ V AD+G + C
Sbjct: 2137 GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAA 2196
Query: 2797 GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSR----VAEGQTLDLKCVVPG 2852
+G + + + ++ PP+ +EP + V G ++L C G
Sbjct: 2197 SPAGVADRNFTLQVQV--------------PPV-LEPVEFQNDVVVVRGSLVELPCEARG 2241
Query: 2853 QAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEP 2912
V+W K G L ++ GP L+L V DSG YSC +G +T+
Sbjct: 2242 VPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTV-- 2299
Query: 2913 SSPGPIPAPGLAQPIYIEASSS----HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR 2968
+P +IE S +T G ++L C G +TW+K G +L R
Sbjct: 2300 -----------MEPPHIEDSGQPTELSLTPGAPMELLCDAQGTPQPNITWHKDGQAL-TR 2347
Query: 2969 HQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV--PPSEGSSYRLRSP--VI 3024
+ + R+ V D+G Y C A S P E SF V V PP+ R P V+
Sbjct: 2348 LENNSRATRVLRVR--DAGLYTCLAES-PAGAIEKSFRVRVQAPPNIVGP---RGPRFVV 2401
Query: 3025 SIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTR 3082
+ P ++ C + AP + W L+++ H G + +
Sbjct: 2402 GLAPGQLVLE--------CSVEAEPAP-KITWHRDGIVLQEDAHTQFPERGRFLQLQALS 2452
Query: 3083 PSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRS 3142
++ G Y C A NA G + +H PT+ P V V V + L C + G P
Sbjct: 2453 TADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPA-VNVSVNQTALLPCQADGVPAP 2511
Query: 3143 SARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV-I 3201
W R P + ++ + L+I DAG Y+CLA N+ G+ ++ ++ +
Sbjct: 2512 LVSW-RKDRVPLDPRSPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRV 2569
Query: 3202 VDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR---- 3257
++ A+AP + LT+ A A L C A+GSP P + W K L ++ +
Sbjct: 2570 LEPPAIAPSP-------SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAY 2622
Query: 3258 --LEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGET 3315
L + L++ QDS Q+ C ++ G A + V PP +V
Sbjct: 2623 RLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAP 2682
Query: 3316 VQLQCLAHGTPPLTFQWSRVGSSLPGRAT----ARNELLHFERAAPEDSGRYRCRVTNKV 3371
V L C + G P T WS+ G+ L R + + + L +A P +GRY C N
Sbjct: 2683 VVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSA 2742
Query: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQL 3431
G A L VQ ++P V+ P + V C +
Sbjct: 2743 GVAHKHVFLTVQ--------------ASPVVKPLPSVVRAVAEEEVLLPCEASGIPRPTI 2788
Query: 3432 RWFKEGGQLPPGHSVQ---DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
W KEG + G S Q G LRI + G Y+C A G A +LV+Q +P
Sbjct: 2789 TWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQ-VPP 2847
Query: 3489 VLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK----VGGHLRPGIVQSGGVVRIAH 3544
V+ N + T HA C A G P+P +TW K V G +Q G + + +
Sbjct: 2848 VIENGLPDLSTTEGSHAF-LPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKN 2906
Query: 3545 VELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVFPCIASGYPT 3603
+E DAG Y CTA NA G + V L + LP + +P + + G C A G PT
Sbjct: 2907 LEGQDAGTYTCTAENAVGRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPT 2966
Query: 3604 PDISWSKLDGSLPPDSRLEN--NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPER 3661
P I W+ D + ++ + L +V +D+GTYVC A NR G+ +A + + V E
Sbjct: 2967 PRIGWTVNDRPVTEGVSEQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE- 3025
Query: 3662 VVPYFTQTPYSFLPLP 3677
P +S+L P
Sbjct: 3026 -APVLQGEAFSYLVEP 3040
Score = 489 bits (1259), Expect = e-137
Identities = 525/1981 (26%), Positives = 792/1981 (39%), Gaps = 238/1981 (12%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQ-QRHQGSE-LHFPSVQPSDAGVYICTCRNL- 1751
SL C+ P W + DG P + Q G+ L + Q DAG Y C N
Sbjct: 1369 SLICEALAFPSPNITWMK-DGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNEL 1427
Query: 1752 -HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLH 1810
E+L+ + SK + + + + +T C + + P T+ W +
Sbjct: 1428 GEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPP-TIRWYKDG 1486
Query: 1811 NGKLPTRAMDFNG---ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS------G 1861
P+ + G +L I+ Q+SD+G Y+C +N+ D + +Q G
Sbjct: 1487 QPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVG 1546
Query: 1862 TLSAPVVSIHPPQLTVQPGQLAEFR-----------CSATGSPTPTLEW--TGGPGGQLP 1908
SA + + G + E+R C P P L W P
Sbjct: 1547 DFSAAFEILSREEEA--RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGD 1604
Query: 1909 AKAQIHGG-ILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP----- 1962
+ + GG +L++P V + +Y C+A + G+ L V P V +
Sbjct: 1605 EVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT---PPVILGDTEELV 1661
Query: 1963 ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE-RTDIATLLIPAITTADAG 2021
E V+A TV L C A G P TI+W + G P R + D L + ADA
Sbjct: 1662 EEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAA 1721
Query: 2022 FYLCVATSPAGTAQA----RIQVVVLSASDASPPPVK-IESSSPSVTEGQTLDLNCVVAG 2076
Y+CVA + AG+A+ R+QV PP + ++ + ++ L C V
Sbjct: 1722 SYMCVAENQAGSAEKLFTLRVQV---------PPRIAGLDLEQVTAILNSSVSLPCDVHA 1772
Query: 2077 SAHAQVTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITV 2132
+ +VTWY+ +L +V L+L + +DSG Y C N +G + + +
Sbjct: 1773 HPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQL 1832
Query: 2133 SVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE-GQTLDLNCVVPGQAHAQVTWHKRGGS 2191
SVL VP + R P + + G L+C VTW+K G
Sbjct: 1833 SVL-----------VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQP 1881
Query: 2192 LPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
L +T G L + + +D G Y C V +G + +T++ +PP
Sbjct: 1882 LVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQ-------VPPT 1934
Query: 2248 RIESSSSTVAE--GQTLDLSCVVAGQAHAQVTWYKRGGSLP--ARHQV--RGSRLYIFQA 2301
+ TV++ G L L+C V+G VTW K + A H V RG RL + +
Sbjct: 1935 FENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGRLQLSRL 1994
Query: 2302 SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLN 2361
PA AG Y C A N + V A +G + V EGQ + L+
Sbjct: 1995 QPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAR-------EHHVLEGQEVRLD 2047
Query: 2362 CVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVL 2421
C GQ V W K G L Q G LR Y D G V + L +S A
Sbjct: 2048 CEADGQPPPDVAWLKDGSPLG---QDMGPHLRFY----LDGGSLVLKGLRAS-DAGAYTC 2099
Query: 2422 VTIEPAGSVPALG-----VTPTVR--IESSSSQVAE-GQTLDLNCLVAGQAHAQVTWHKR 2473
V PAG L V PT++ + S + V+ G+ + + C V G V+W K
Sbjct: 2100 VAHNPAGEDARLHTVNVLVPPTIKQGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKD 2159
Query: 2474 GGSLPA--RHQVHGS--RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHS 2529
G LP R +HGS LR+ +V AD+G + C +G + + + +Q
Sbjct: 2160 GLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVADRNFTLQVQV------- 2212
Query: 2530 QGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQ 2589
V PV ++ + G ++L C ++W K G L S+ G L++
Sbjct: 2213 PPVLEPVEFQNDVV-VVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEA 2271
Query: 2590 VTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT---VVEGQT 2646
V DSG Y C + AG +T+ + PP +S PT + G
Sbjct: 2272 VGAGDSGTYSCVAVSEAGEARRHFQLTV----------MEPPHIEDSGQPTELSLTPGAP 2321
Query: 2647 LDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALE 2706
++L C PQ ITW+K G +L +R + + R+ + V D+G Y C A + A+E
Sbjct: 2322 MELLCDAQGTPQPNITWHKDGQAL-TRLENNSRATRV--LRVRDAGLYTCLAESPAGAIE 2378
Query: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGS 2766
S + V P+ G P + +A G+ L L C V + ++TWH+ G
Sbjct: 2379 KSFRVRVQ---APPNIVGPRGPRFVVG----LAPGQ-LVLECSVEAEPAPKITWHRDGIV 2430
Query: 2767 LPSHHQT----RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPA 2822
L T RG L+L +S ADSG+Y C ++G + V I
Sbjct: 2431 LQEDAHTQFPERGRFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHT---------- 2480
Query: 2823 PGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL----L 2878
P IR P + V+ QT L C G V+W K L R L L
Sbjct: 2481 ---VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGSL 2537
Query: 2879 RLNQVSPADSGEYSCQVTGSSGT-LEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
R+ V D+G Y C + S+G+ + L +EP + P P S+ +T
Sbjct: 2538 RIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSP------------SNLTLT 2585
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGP 2997
L C G V W+K G L R Q +L P+++ + P
Sbjct: 2586 AHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLL-----PSNA-----LLLTAP 2635
Query: 2998 GPEQEASFTVTVPPSEGSSYRLRS------PVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
GP+ A F V G ++RL P I+ D TV C AP
Sbjct: 2636 GPQDSAQFECVVSNEVGEAHRLYQVTVHVPPTIADDQTDFTVTMMAPVVLTCHSTGIPAP 2695
Query: 3052 ISLEWKTRNQELE---DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV 3108
++ W +L +SP+G++ I P + G Y C A N+ GVA V L+V
Sbjct: 2696 -TVSWSKAGAQLGARGSGYRVSPSGAL-EIGQALPIHAGRYTCSARNSAGVAHKHVFLTV 2753
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHA 3168
P V LP V + V L C ++G PR + W + A T L
Sbjct: 2754 QASPVVKPLPS-VVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVAT-GVSTQVLPGGQ- 2810
Query: 3169 VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHT 3228
L+I+ A P DAG Y+C+A+N+ G+A + ++V P ++ +L+ G
Sbjct: 2811 -LRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQV------PPVIENGLPDLSTTEGSH 2863
Query: 3229 ATLRCSATGSPAPTIHWSKLRSPLPWQHRL----EGDTLIIPRVAQQDSGQYICNATSPA 3284
A L C A GSP P I W K P+ L++ + QD+G Y C A +
Sbjct: 2864 AFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTAENAV 2923
Query: 3285 GHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRAT 3344
G A + L + P TT+P S++ G+ + L+C A G+P W+ + +
Sbjct: 2924 GRARRRVHLTILVLPVFTTLPGDRSLRLGDRLWLRCAARGSPTPRIGWTVNDRPVTEGVS 2983
Query: 3345 ARNELLHFERAAP--EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTV 3402
++ +RAA EDSG Y C N+VG +A + + V+ P + G +
Sbjct: 2984 EQDGGSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKEAP-------VLQGEAFSY 3036
Query: 3403 QVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGH---SVQDGVLRIQNLDQS 3459
V P +G S++ C V D + W K+G L H +Q+G L I ++
Sbjct: 3037 LVEP------VGGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERD 3090
Query: 3460 CQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQ 3519
G Y C A G A+ LV+Q+ P + + TV G V C A G+P P
Sbjct: 3091 DAGRYQCLAENEMGVAKKVVILVLQSAP--VFQVEPQDMTVRSGDDVALRCQATGEPTPT 3148
Query: 3520 VTWSKVGGHLRPGI---VQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALP 3576
+ W + G LR G + + +VE DAG Y C A N G+ + L+V+ P
Sbjct: 3149 IEWLQAGQPLRASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208
Query: 3577 Q 3577
Q
Sbjct: 3209 Q 3209
Score = 487 bits (1254), Expect = e-137
Identities = 547/2127 (25%), Positives = 800/2127 (37%), Gaps = 257/2127 (12%)
Query: 1664 QGGQCLPETNQAPLVVEVHPARS----IVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVP 1719
Q G+ N V V P R V +G SL C+ G P W R+DG+P+P
Sbjct: 955 QAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRGVPFPKISW-RKDGQPLP 1013
Query: 1720 S-GTQQRHQ---GSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTV 1775
G +H G L+ Q + G Y C C N+ +++ +L V P I
Sbjct: 1014 GEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQ--IAGPR 1071
Query: 1776 EEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN---GKLPTRAMDFNGILTIRNVQL 1832
E SV T C A K P T+ W R +L + + L + Q
Sbjct: 1072 EPPTQVSVVQDGVATLECNATGKPPP-TVTWERDGQPVGAELGLQLQNQGQSLHVERAQA 1130
Query: 1833 SDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGS 1892
+ G Y C N+ + L V L + + +T C A G
Sbjct: 1131 AHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPL--TNITAALHSPLTLLCEAMGI 1188
Query: 1893 PTPTLEWTGGPGGQLPAKAQI---HGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLH 1949
P P + W G P + G +L++ + D Y C A + AG+ AR
Sbjct: 1189 PPPAIRWFRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGE--ARRNFS 1246
Query: 1950 VHGGGGPRVQVSP--ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPP-QARSERTD 2006
V P ++ E +V G+T L C G P +TW K+G L A D
Sbjct: 1247 VEVLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPD 1306
Query: 2007 IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQ 2066
L + + AG Y C+A + G Q+ VL A +VT
Sbjct: 1307 GVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEEVTVTVNN 1366
Query: 2067 TLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV------HGSRLRLPQVSPADSGEYVCRVE 2120
+ L C +TW + G + HG L++ D+G+Y C V
Sbjct: 1367 PISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVT 1424
Query: 2121 NGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPI-RIEPSSSHVAEGQTLDLNCVVPGQA 2179
N G + V VL P P+ + TL L C
Sbjct: 1425 NELGEAVKNYHVEVL--------IPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVP 1476
Query: 2180 HAQVTWHKRGGSLPARHQTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
+ W+K G + + G LL++ +DSG Y+C +G + V I
Sbjct: 1477 PPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLI 1536
Query: 2236 EASVIPGPIPPV---------------RIESSSSTVAEGQTLD------LSCVVAGQAHA 2274
+ +PP+ R E + V E + + L C
Sbjct: 1537 Q-------VPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPP 1589
Query: 2275 QVTWYKRGGSLPARHQVR----GSRLYIFQASPADAGQYVCRASN--GMEASITVTVTGT 2328
+TWY+ L A +V G L I +AG+Y C+ASN G + + T
Sbjct: 1590 DLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLT 1649
Query: 2329 QGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG----GSLPVR 2384
L + + + SS T+ L C G ++W + G S ++
Sbjct: 1650 PPVILGDTEELVEEVTVNASS-------TVSLQCPALGNPVPTISWLQNGLPFSPSPRLQ 1702
Query: 2385 HQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESS 2444
G +L++ A AD+ Y+C + E + ++ + L + I +S
Sbjct: 1703 VLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNS 1762
Query: 2445 SSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL---------PARHQVHGSRLRLLQVTP 2495
S + L C V + +VTW+K +L P H + R RL
Sbjct: 1763 S--------VSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL----- 1809
Query: 2496 ADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNC 2555
+DSG Y C + ++G + LV + + + Q P + + G L+C
Sbjct: 1810 SDSGMYTCEALNAAGRDQK--LVQLSVLVPPAFRQAPRGP----QDAVLVRVGDKAVLSC 1863
Query: 2556 LVASQAPHTITWYKRGGSL--PSRHQIV--GSRLRIPQVTPADSGEYVCHVSNGAGSRET 2611
+ T+TWYK G L R Q + G RL I + +D G Y C VSN AG
Sbjct: 1864 ETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVR 1923
Query: 2612 SLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP 2671
+ +T+Q VP + E+ S V G L L C V+ P +TW K +
Sbjct: 1924 TFTLTVQ------VPPTFENPKTETVSQ--VAGSPLVLTCDVSGVPAPTVTWLKDRMPVE 1975
Query: 2672 SRHQ----THGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSM 2727
S + G L+L ++ A +G Y C A N V++V +
Sbjct: 1976 SSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAP---------- 2025
Query: 2728 PIRIESSS----SHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS------HHQTRGSR 2777
RI SS HV EG+ + L+C GQ V W K G L G
Sbjct: 2026 --RIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGS 2083
Query: 2778 LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSR 2837
L L + +D+G Y C +G E + L T+ + A G +
Sbjct: 2084 LVLKGLRASDAGAYTCVAHNPAG--EDARLHTVNVLVPPTIKQGADGSGTLVS------- 2134
Query: 2838 VAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA--RHQVHGP--LLRLNQVSPADSGEYSC 2893
G+ + + C V G V+W K G LP R +HG LR+++V AD+G ++C
Sbjct: 2135 -RPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTC 2193
Query: 2894 QVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAH 2953
+G + + + ++ P + +P+ + + V G ++L C G
Sbjct: 2194 VAASPAGVADRNFTLQVQ--------VPPVLEPVEFQ-NDVVVVRGSLVELPCEARGVPL 2244
Query: 2954 AQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGP-EQEASFTVTVPPS 3012
V+W K G L ++ G L+L V DSG Y C A S G + TV PP
Sbjct: 2245 PLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPH 2304
Query: 3013 EGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN 3072
S + P ++ G C P ++ W Q L + N
Sbjct: 2305 IEDSGQ---------PTELSLTPGAPMELLCDAQGTPQP-NITWHKDGQAL---TRLENN 2351
Query: 3073 GSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKA--- 3129
++ R + G Y C+A + G + + V PP + V P GP +V VG A
Sbjct: 2352 SRATRVLRVRDA--GLYTCLAESPAGAIEKSFRVRVQAPPNI-VGPRGPRFV-VGLAPGQ 2407
Query: 3130 VTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQN 3189
+ LEC EP W R E + LQ+ + +D+G Y C A+N
Sbjct: 2408 LVLECSVEAEPAPKITWHRDGIVLQ--EDAHTQFPERGRFLQLQALSTADSGDYSCTARN 2465
Query: 3190 ALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLR 3249
A G+ V + T P +++ + V TA L C A G PAP + W K R
Sbjct: 2466 AAGSTSVAFRVEIHT------VPTIRSGPPAVNVSVNQTALLPCQADGVPAPLVSWRKDR 2519
Query: 3250 SPL----PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP 3305
PL P L +L I V QD+G Y+C A++ AG L V PP P
Sbjct: 2520 VPLDPRSPRFEILPEGSLRIQPVLAQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSP 2579
Query: 3306 EHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATAR------NELLHFERAAPED 3359
+ ++ A L C A G+P W + G L R + L P+D
Sbjct: 2580 SNLTLTAHTPALLPCEASGSPKPLVVWWKDGQKLDFRLQQGAYRLLPSNALLLTAPGPQD 2639
Query: 3360 SGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF 3419
S ++ C V+N+VG A Q+ V PP T+ T ++ A V
Sbjct: 2640 SAQFECVVSNEVGEAHRLYQVTVHVPP--------------TIADDQTDFTVTMMAPVVL 2685
Query: 3420 HCAVPSDRGTQLRWFKEGGQLPP---GHSVQ-DGVLRIQNLDQSCQGTYICQAHGPWGKA 3475
C + W K G QL G+ V G L I G Y C A G A
Sbjct: 2686 TCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSGALEIGQALPIHAGRYTCSARNSAGVA 2745
Query: 3476 QASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI-- 3533
L +QA P ++ SV V V C A G P+P +TW K G ++ G+
Sbjct: 2746 HKHVFLTVQASP--VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVST 2803
Query: 3534 -VQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI--SMPQEVRVPAGS 3590
V GG +RIAH DAG Y C A N+AG+ L+VQ P I +P ++ GS
Sbjct: 2804 QVLPGGQLRIAHASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLP-DLSTTEGS 2862
Query: 3591 AAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPS-------VRPQDAGTYVCTA 3643
A PC A G P P+I+W K DG P S E + PS + QDAGTY CTA
Sbjct: 2863 HAFLPCKARGSPEPNITWDK-DGQ--PVSGAEGKFTIQPSGELLVKNLEGQDAGTYTCTA 2919
Query: 3644 TNRQGKVKAFAHLQVPERVVPYFTQTP 3670
N G+ + HL + V+P FT P
Sbjct: 2920 ENAVGRARRRVHLTI--LVLPVFTTLP 2944
Score = 444 bits (1141), Expect = e-123
Identities = 547/2158 (25%), Positives = 803/2158 (37%), Gaps = 272/2158 (12%)
Query: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGS 1693
G Y+C A P GQ P++ G ET + V+E H +
Sbjct: 285 GRYQCVAFSPA--GQQARDFQLRVHAPPTIWGSN---ETGEVA-VMEDHLVQ-------- 330
Query: 1694 HSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQ--GSELHFPSVQPSDAGVYICTCRNL 1751
L C+ G P W + DG +P+ T+ + G +L Q SDAGVY C N
Sbjct: 331 --LLCEARGVPTPNITWFK-DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNA 387
Query: 1752 HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRP--GADVTFICTAKSKSPAYTLVWTRL 1809
+ L V P T+ R V+ G V C A+ P+ TL W
Sbjct: 388 VGAAEKATRLDVYVPP----TIEGAGGRPYVVKAVAGRPVALECVARGH-PSPTLSW--- 439
Query: 1810 HNGKLP------TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTL 1863
H+ LP +R +L + + + +G Y C S+ ++ VQ L
Sbjct: 440 HHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQVPPQL 499
Query: 1864 SAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW--TGGPGGQLP-AKAQIHGGILRL 1920
+V+ Q+T GQ E C A+GSP PT++W G P +L + G L +
Sbjct: 500 ---LVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHI 556
Query: 1921 PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAA 1980
VE + C+A + AG A + VHG P V P Q H G AA
Sbjct: 557 DHVELDHSGLFACQATNEAGTAGAEVEVSVHGEWAPGVLEVP-IGQYHWGXEHHSSFPAA 615
Query: 1981 GVPSATITWRK-------EGGSLPPQARSERTDIAT-------LLIPAITTADAGFYLCV 2026
P W EG P E T I L I + D G Y C
Sbjct: 616 CDPPVHRGWGAHPKPPLVEGWCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLRDEGIYTCA 675
Query: 2027 ATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYR 2086
AT+ AG ++ + + VL + P PV + +V E ++ L C+ +G V+W++
Sbjct: 676 ATNLAGESKREVALKVLVPPNIEPGPV-----NKAVLENASVTLECLASGVPPPDVSWFK 730
Query: 2087 RGGSLPPHT------QVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHS 2140
G P + V G LR+ Q +D+G Y C N +G E + V +
Sbjct: 731 --GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRV----NV 784
Query: 2141 GPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRG------GSLPA 2194
P T P P+ + + L C G + W K G G+
Sbjct: 785 PPRITLPPSLPGPVLV---------NTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGL 835
Query: 2195 RHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSS 2254
+ G +L L +DSG Y C V G V++ + P + E +
Sbjct: 836 QVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMP------PSILGEELNV 889
Query: 2255 TVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSR----LYIFQASPADAGQYV 2310
+V +++ L C ++W+K G L R V S L + +A DAG Y
Sbjct: 890 SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYT 949
Query: 2311 CRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHA 2370
C A N S + NL P+R E + V EG L+C G
Sbjct: 950 CEALNQAGRS-------EKHYNLNVWVAPVFPLR-ESHTLTVREGHPTSLSCECRGVPFP 1001
Query: 2371 QVTWHKRGGSLP-----VRH-QTHGSLLRLYQASPADSGEYVCR----VLGSSVPLEASV 2420
+++W K G LP ++H G LL L QA A G Y C V SS L+ V
Sbjct: 1002 KISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEV 1061
Query: 2421 LVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKR----GGS 2476
V + AG R + V + L C G+ VTW + G
Sbjct: 1062 HVPPQIAGP----------REPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAE 1111
Query: 2477 LPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPV 2536
L + Q G L + + A +G Y C +G E +++ L G P+
Sbjct: 1112 LGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV---LVPPELIGDLDPL 1168
Query: 2537 RIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV-----GSRLRIPQVT 2591
++ + A L L C P I W+ RG S + G L++ Q
Sbjct: 1169 ----TNITAALHSPLTLLCEAMGIPPPAIRWF-RGEEPVSPGEDTYLLAGGWMLKMTQTQ 1223
Query: 2592 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT--VVEGQTLDL 2649
DSG Y C SN AG + V + V P I E V++GQT L
Sbjct: 1224 EQDSGLYSCLASNEAGEARRNFSVEV---------LVPPSIENEDLEEVIKVLDGQTAHL 1274
Query: 2650 NCVVARQPQAIITWYKRGGSLPSRHQTH----GSHLRLHQMSVADSGEYVCRANNNIDA- 2704
C V PQ +TW+K G L H G L++ Q +++ +G Y C A N +
Sbjct: 1275 MCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEK 1334
Query: 2705 ---LEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWH 2761
+ S++++ + G+ + + + + + + L C +TW
Sbjct: 1335 TKHFQLSVLLAPTILGGAEDSADEEVTVTVNN---------PISLICEALAFPSPNITWM 1385
Query: 2762 KRGGSLPSHHQ------TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGS 2815
K G + T G L++ + D+G+Y C V G EA +E
Sbjct: 1386 KDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVTNELG--EAVKNYHVEVLIP 1441
Query: 2816 SAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL--PARHQV 2873
++ P G ++ + TL L+C + W+K G + +R QV
Sbjct: 1442 PSISKDDPLGEVGVK----EVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQV 1497
Query: 2874 --HGPLLRLNQVSPADSGEYSCQVTGSSG--TLEASVLVTIEP--SSPGPIPAPGLAQPI 2927
G LL++ +DSG Y C T +G + +VL+ + P G A
Sbjct: 1498 LGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAAFEILSR 1557
Query: 2928 YIEASSS-----HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH----GSQLRL 2978
EA + E L C +TWY+ L A + G L++
Sbjct: 1558 EEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQI 1617
Query: 2979 HLVSPADSGEYVCRAASGPGPE--QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQG 3036
LV ++G Y C+A++ G + +T P G + L V TV
Sbjct: 1618 PLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEV--------TVNAS 1669
Query: 3037 QDASFKCLIHDGAAPISLEWKTRNQELEDN--VHISPNGSIITIVGTRPSNHGTYRCVAS 3094
S +C P ++ W + + + +G ++ + ++ +Y CVA
Sbjct: 1670 STVSLQCPALGNPVP-TISWLQNGLPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAE 1728
Query: 3095 NAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPA 3154
N G A+ + L V PP ++ L V + +V+L C P W + S
Sbjct: 1729 NQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYK-DSQAL 1787
Query: 3155 KLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV 3214
L + + L +H LQ+ A+ SD+G Y C A NA G QK V++ V AP
Sbjct: 1788 SLGEEVFLLPGTH-TLQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAP-- 1844
Query: 3215 QAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE----GDTLIIPRVAQ 3270
+ + + V G A L C P PT+ W K PL R + G L I
Sbjct: 1845 RGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQRLEIQEAQV 1904
Query: 3271 QDSGQYICNATSPAGHAEATIILHVESPP-YATTVPEHASVQAGETVQLQCLAHGTPPLT 3329
D G Y C ++ AG A T L V+ PP + E S AG + L C G P T
Sbjct: 1905 SDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPT 1964
Query: 3330 FQWSR----VGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP 3385
W + V SS +R L R P +G Y C N AEA +V
Sbjct: 1965 VTWLKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENT--QAEARKDFVV--- 2019
Query: 3386 PGSLPATSIPAGSTPTVQVTPQLETKSI--------GASVEFHCAVPSDRGTQLRWFKEG 3437
V V P++ + + G V C + W K+G
Sbjct: 2020 ---------------AVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDVAWLKDG 2064
Query: 3438 GQLPPGHS------VQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLI 3491
L + G L ++ L S G Y C AH P G+ A V +P +
Sbjct: 2065 SPLGQDMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAGE-DARLHTVNVLVPPTIK 2123
Query: 3492 NIRTSVQTVV--VGHAVEFECLALGDPKPQVTWSKVGGHL----RPGIVQSGGVVRIAHV 3545
T+V G V C G P V+W K G L R + SG +RI+ V
Sbjct: 2124 QGADGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKV 2183
Query: 3546 ELADAGQYRCTATNAAGTTQSHVLLLVQALP---QISMPQEVRVPAGSAAVFPCIASGYP 3602
+LADAG + C A + AG + L VQ P + +V V GS PC A G P
Sbjct: 2184 QLADAGIFTCVAASPAGVADRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVP 2243
Query: 3603 TPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE 3660
P +SW K L S + L L +V D+GTY C A + G+ + L V E
Sbjct: 2244 LPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVME 2301
Score = 436 bits (1122), Expect = e-121
Identities = 501/1875 (26%), Positives = 729/1875 (38%), Gaps = 258/1875 (13%)
Query: 1685 RSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAG 1742
R IV ++ L C + PP W RED +P+ +G + G L P V+ +AG
Sbjct: 1569 REIVENNPAY-LYCDTNAIPPPDLTWYRED-QPLSAGDEVSVLQGGRVLQIPLVRAENAG 1626
Query: 1743 VYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAY 1802
Y C N + ELLV P + T E +V + V+ C A +P
Sbjct: 1627 RYSCKASNEVGEDWLHYELLVL-TPPVILGDTEELVEEVTVNASSTVSLQCPALG-NPVP 1684
Query: 1803 TLVWTRLHNGKLP------TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLH 1856
T+ W L NG LP + ++ +L + +++DA +Y+C N + TL
Sbjct: 1685 TISW--LQNG-LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLR 1741
Query: 1857 VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW--------TGGPGGQLP 1908
VQ + + + Q+T C P P + W G LP
Sbjct: 1742 VQ----VPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTWYKDSQALSLGEEVFLLP 1797
Query: 1909 AKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQ-- 1966
+ G RL +D Y C A ++AG+ L V P + +P Q
Sbjct: 1798 GTHTLQLGRARL-----SDSGMYTCEALNAAGRDQKLVQLSVLVP--PAFRQAPRGPQDA 1850
Query: 1967 --VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT----LLIPAITTADA 2020
V G L C +P T+TW K+G P ++RT L I +D
Sbjct: 1851 VLVRVGDKAVLSCETDALPEPTVTWYKDG---QPLVLAQRTQALRGGQRLEIQEAQVSDK 1907
Query: 2021 GFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080
G Y C ++ AG A + V P ++ + S G L L C V+G
Sbjct: 1908 GLYSCKVSNVAGEAVRTFTLTVQVPPTFENP----KTETVSQVAGSPLVLTCDVSGVPAP 1963
Query: 2081 QVTWYRRGGSLPPHTQ-VHG-----SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
VTW + +P + VHG RL+L ++ PA +G Y C EN V+V
Sbjct: 1964 TVTWLK--DRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAV 2021
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194
L S G R HV EGQ + L+C GQ V W K G L
Sbjct: 2022 LVAPRIRSS-----GVAR-------EHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQ 2069
Query: 2195 RHQTH------GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVR 2248
H G L L + +D+G Y C +G E + L T+ ++P I
Sbjct: 2070 DMGPHLRFYLDGGSLVLKGLRASDAGAYTCVAHNPAG--EDARLHTVNV-LVPPTIKQGA 2126
Query: 2249 IESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV----RGSRLYIFQASPA 2304
S + G+ + + C V G V+W K G LP + G L I + A
Sbjct: 2127 DGSGTLVSRPGELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLA 2186
Query: 2305 DAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQ----VAEGQTLDL 2360
DAG + C + + G N P +EP Q V G ++L
Sbjct: 2187 DAGIFTC---------VAASPAGVADRNFTLQV--QVPPVLEPVEFQNDVVVVRGSLVEL 2235
Query: 2361 NCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASV 2420
C G V+W K G L + G L+L DSG Y C + +
Sbjct: 2236 PCEARGVPLPLVSWMKDGEPLLSQSLEQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHF 2295
Query: 2421 LVT------IEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG 2474
+T IE +G L +TP G ++L C G +TWHK G
Sbjct: 2296 QLTVMEPPHIEDSGQPTELSLTP-------------GAPMELLCDAQGTPQPNITWHKDG 2342
Query: 2475 GSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAY 2534
+L R + + R+L+V D+G Y C +G E S V +Q + +G +
Sbjct: 2343 QAL-TRLENNSRATRVLRVR--DAGLYTCLAESPAGAIEKSFRVRVQAPPNIVGPRGPRF 2399
Query: 2535 PVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP----SRHQIVGSRLRIPQV 2590
V LA G L L C V ++ ITW++ G L ++ G L++ +
Sbjct: 2400 VV-------GLAPGQ-LVLECSVEAEPAPKITWHRDGIVLQEDAHTQFPERGRFLQLQAL 2451
Query: 2591 TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLN 2650
+ ADSG+Y C N AGS + V I P IR + V QT L
Sbjct: 2452 STADSGDYSCTARNAAGSTSVAFRVEIH---------TVPTIRSGPPAVNVSVNQTALLP 2502
Query: 2651 CVVARQPQAIITWYKRGGSLPSRHQT-----HGSHLRLHQMSVADSGEYVCRANNNIDAL 2705
C P +++W K L R GS LR+ + D+G Y+C A+N+ +
Sbjct: 2503 CQADGVPAPLVSWRKDRVPLDPRSPRFEILPEGS-LRIQPVLAQDAGHYLCLASNSAGSD 2561
Query: 2706 EASIVISV-SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRG 2764
+ V P A +PS ++ + L C G V W K G
Sbjct: 2562 RQGRDLRVLEPPAIAPSPSNLTLTAHTPAL-----------LPCEASGSPKPLVVWWKDG 2610
Query: 2765 GSLPSHHQTRGSRLR------LHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAV 2818
L Q RL L P DS ++ C V G VT V
Sbjct: 2611 QKLDFRLQQGAYRLLPSNALLLTAPGPQDSAQFECVVSNEVGEAHRLYQVT--------V 2662
Query: 2819 HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH---- 2874
HVP P I + + V + L C G V+W K G L AR +
Sbjct: 2663 HVP-----PTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSP 2717
Query: 2875 GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 2934
L + Q P +G Y+C S+G V +T++ +SP P P + +
Sbjct: 2718 SGALEIGQALPIHAGRYTCSARNSAGVAHKHVFLTVQ-ASPVVKPLPSVVRA-------- 2768
Query: 2935 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH---GSQLRLHLVSPADSGEYVC 2991
V E + L L C G +TW K G ++ T G QLR+ SP D+G Y+C
Sbjct: 2769 -VAEEEVL-LPCEASGIPRPTITWQKEGLNVATGVSTQVLPGGQLRIAHASPEDAGNYLC 2826
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
A + G + V P PVI P + +G A C P
Sbjct: 2827 IAKNSAGSAMGKTRLVVQVP----------PVIENGLPDLSTTEGSHAFLPCKARGSPEP 2876
Query: 3052 ISLEWKTRNQEL---EDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV 3108
++ W Q + E I P+G ++ + + GTY C A NA G A+ V+L++
Sbjct: 2877 -NITWDKDGQPVSGAEGKFTIQPSGELL-VKNLEGQDAGTYTCTAENAVGRARRRVHLTI 2934
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGL--MDS 3166
P + LP G +++G + L C + G P WT ++ P T G+ D
Sbjct: 2935 LVLPVFTTLP-GDRSLRLGDRLWLRCAARGSPTPRIGWT-VNDRPV-----TEGVSEQDG 2987
Query: 3167 HAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE-A 3225
+ LQ ++ D+GTYVC A+N +G Q V V AP +Q E VE
Sbjct: 2988 GSTLQRAAVSREDSGTYVCWAENRVGRTQAVSFVHVKE------APVLQGEAFSYLVEPV 3041
Query: 3226 GHTATLRCSATGSPAPTIHWSKLRSPLPW---QHRLEGDTLIIPRVAQQDSGQYICNATS 3282
G + L C G P P IHW K PL +H+L+ +L I R + D+G+Y C A +
Sbjct: 3042 GGSIQLDCVVRGDPVPDIHWIKDGLPLRGSHLRHQLQNGSLTIHRTERDDAGRYQCLAEN 3101
Query: 3283 PAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR 3342
G A+ +IL ++S P P+ +V++G+ V L+C A G P T +W + G P R
Sbjct: 3102 EMGVAKKVVILVLQSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEWLQAGQ--PLR 3159
Query: 3343 ATAR-----NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP----GSLPATS 3393
A+ R + L E D+G Y C N +GSA A A L+V+G P GS+ T
Sbjct: 3160 ASRRLRTLPDGSLWLENVETGDAGTYDCVAHNLLGSATARAFLVVRGEPQGSWGSM--TG 3217
Query: 3394 IPAG---STPTVQVTPQLETKSIGASVEFHCA-VPSDRGTQLR----------W--FKEG 3437
+ G T+ + E S +S+ VP++ G +R W +E
Sbjct: 3218 VINGRKFGVATLNTSVMQEAHSGVSSIHSSIRHVPANVGPLMRVLVVTIAPIYWALARES 3277
Query: 3438 GQLPPGHSVQDGVLR 3452
G+ GHS+ G R
Sbjct: 3278 GEALNGHSLTGGRFR 3292
Score = 429 bits (1104), Expect = e-119
Identities = 550/2165 (25%), Positives = 807/2165 (37%), Gaps = 345/2165 (15%)
Query: 1678 VVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSRED------GRPVPSGTQQRHQGSEL 1731
V+E+ + G + C G+P W + G+P G +GS L
Sbjct: 4 VLEIKGLGDVALTVGLEAGGCGTHGTPKPQVTWRKGPSSEPLHGQP---GVAVLEEGS-L 59
Query: 1732 HFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVR--PGADV 1789
SV P+D+G Y C N S + RA+L+V PS E+ R +V G +
Sbjct: 60 FLASVSPADSGDYECQATNEVGSTSRRAKLVVYVPPS-----IREDGRKANVSGMAGQSL 114
Query: 1790 TFICTAKSKSPAYTLVWTR-----------------LHNGKLPT-RAMDFNGILTIRNVQ 1831
T C A P +VW + L G++ R +D L +Q
Sbjct: 115 TLECDANG-FPVPEIVWLKDAQLVGVPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQ 173
Query: 1832 LSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPP-------------QLTVQ 1878
+G G+ Q A +G P P ++
Sbjct: 174 PGRSGR---RGAQAGGSAQTKAPWXAGLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGL 230
Query: 1879 PGQLAEFRCSATGSPTPTLEWTGGPGGQLPA----KAQIHGGILRLPAVEPTDQAQYLCR 1934
G E +C +G PTP +EWT LP + Q G +LR+ D+ +Y C
Sbjct: 231 AGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCV 290
Query: 1935 AHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHA--GRTVRLYCRAAGVPSATITWRKE 1992
A S AGQQ L VH P + S E +V V+L C A GVP+ ITW K+
Sbjct: 291 AFSPAGQQARDFQLRVHAP--PTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKD 348
Query: 1993 GGSLPPQARSERT-DIATLLIPAITTADAGFYLCVATSPAGTAQ--ARIQVVVLSASDAS 2049
G LP + T L + ++DAG Y C A++ G A+ R+ V V
Sbjct: 349 GALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGAAEKATRLDVYV------- 401
Query: 2050 PPPVKIESSSPSVTE---GQTLDLNCVVAGSAHAQVTWYRRG----GSLPPHTQVHGSRL 2102
PP ++ P V + G+ + L CV G ++W+ G S + GS L
Sbjct: 402 PPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDGSVL 461
Query: 2103 RLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSH 2162
RL A SG Y C + +G +V V P G + I
Sbjct: 462 RLESPGEASSGLYSCVASSPAGEAVLQYSVEV----QVPPQLLVAEGLGQVTTI------ 511
Query: 2163 VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH------QTHGSLLRLHQVTPADSGEY 2216
GQ L+L C G + W + G PA + G+ L + V SG +
Sbjct: 512 --VGQPLELPCQASGSPVPTIQWLQNG--RPAEELAGVQVASQGTTLHIDHVELDHSGLF 567
Query: 2217 VCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC---------- 2266
C +G A V V++ PG + V I + +C
Sbjct: 568 ACQATNEAGTAGAEVEVSVHGEWAPG-VLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 626
Query: 2267 -----VVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASI 2321
+V G W + G +P + + L I + D G Y C A+N
Sbjct: 627 HPKPPLVEGWCSPGSLWGEPTG-IPVAYSL-PPPLQIEKVDLRDEGIYTCAATN------ 678
Query: 2322 TVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL 2381
+ G +A I P + V E ++ L C+ G V+W K G
Sbjct: 679 ---LAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLECLASGVPPPDVSWFK--GHQ 733
Query: 2382 PVRH------QTHGSLLRLYQASPADSGEYVCRV--LGSSVPLEASVLVTIEPAGSVPAL 2433
PV G +LR+ QA +D+G Y C + S L + V + P ++P
Sbjct: 734 PVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLP-- 791
Query: 2434 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL-----PARHQVHGSR- 2487
S V + L C G + W K G + P G R
Sbjct: 792 --------PSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRV 843
Query: 2488 LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLAN 2547
L L +DSG Y C V + G V++ + S + E + S+
Sbjct: 844 LTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPS----------ILGEELNVSVVA 893
Query: 2548 GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSR----LRIPQVTPADSGEYVCHVS 2603
++ L C + P ++W+K G L R + S L++ + D+G Y C
Sbjct: 894 NESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEAL 953
Query: 2604 NGAGSRETSLIVTIQGSGSSHVPSVSP--PIRIESSSPTVVEGQTLDLNCVVARQPQAII 2661
N AG E + + V+P P+R ES + TV EG L+C P I
Sbjct: 954 NQAGRSEKHYNLNVW---------VAPVFPLR-ESHTLTVREGHPTSLSCECRGVPFPKI 1003
Query: 2662 TWYKRGGSLPSRH------QTHGSHLRLHQMSVADSGEYVCRANNNI--DALEASIVISV 2713
+W K G LP G L L Q +A G Y C +N + + + + + V
Sbjct: 1004 SWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHV 1063
Query: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKR----GGSLPS 2769
P P P + + V + L C G+ VTW + G L
Sbjct: 1064 PPQIAGPREPPTQV---------SVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGL 1114
Query: 2770 HHQTRGSRLRLHHVSPADSGEYVCRVMGSSG----PLEASVLVTIEASG--------SSA 2817
Q +G L + A +G Y C +G E SVLV E G ++A
Sbjct: 1115 QLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAA 1174
Query: 2818 VHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL 2877
+H P + I P + R G+ + V PG+ T+ G G +
Sbjct: 1175 LHSPLTLLCEAMGIPPPAIRWFRGE----EPVSPGED----TYLLAG----------GWM 1216
Query: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
L++ Q DSG YSC + +G EA ++E P I L + I V
Sbjct: 1217 LKMTQTQEQDSGLYSCLASNEAG--EARRNFSVEVLVPPSIENEDLEEVI-------KVL 1267
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH-----GSQLRLHLVSPADSGEYVCR 2992
+GQT L C V G ++TW+K G L AR H G L++ + + +G Y C
Sbjct: 1268 DGQTAHLMCNVTGHPQPKLTWFKDGRPL-ARGDAHHISPDGVLLQVLQANLSSAGHYSCI 1326
Query: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS-----TVQQGQDASFKCLIHD 3047
AA+ G E+ F ++V L +P I S TV S C
Sbjct: 1327 AANAVG-EKTKHFQLSV---------LLAPTILGGAEDSADEEVTVTVNNPISLICEALA 1376
Query: 3048 GAAPISLEWKTRNQ--ELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVN 3105
+P ++ W E N+ + P + I+ + + G Y CV +N G A +
Sbjct: 1377 FPSP-NITWMKDGAPFEASRNIQLLPGTHGLQILNAQKEDAGQYTCVVTNELGEAVKNYH 1435
Query: 3106 LSVHGPPTVSV-LPEGPVWV-----KVGKAVTLECVSAGEPRSSARWTRISS--TPAKLE 3157
+ V PP++S P G V V KV +TLEC S P + RW + TP+
Sbjct: 1436 VEVLIPPSISKDDPLGEVGVKEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRL 1495
Query: 3158 QRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAM------APGA 3211
Q ++ +LQI + SD+G Y+C+A N G + V++ M A
Sbjct: 1496 Q----VLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQKVGDFSAA 1551
Query: 3212 PQVQAEEAEL--------TVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE---- 3259
++ + E E + + A L C P P + W + PL +
Sbjct: 1552 FEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPLSAGDEVSVLQG 1611
Query: 3260 GDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY----ATTVPEHASVQAGET 3315
G L IP V +++G+Y C A++ G L V +PP + E +V A T
Sbjct: 1612 GRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEELVEEVTVNASST 1671
Query: 3316 VQLQCLAHGTPPLTFQWSRVGSSLPGRATAR------NELLHFERAAPEDSGRYRCRVTN 3369
V LQC A G P T W + G LP + R ++L A D+ Y C N
Sbjct: 1672 VSLQCPALGNPVPTISWLQNG--LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAEN 1729
Query: 3370 KVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGT 3429
+ GSAE L VQ PP QVT L +SV C V +
Sbjct: 1730 QAGSAEKLFTLRVQVPP--------RIAGLDLEQVTAIL-----NSSVSLPCDVHAHPNP 1776
Query: 3430 QLRWFKEGGQ---------LPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQ 3480
++ W+K+ LP H++Q G R+ S G Y C+A G+ Q Q
Sbjct: 1777 EVTWYKDSQALSLGEEVFLLPGTHTLQLGRARL-----SDSGMYTCEALNAAGRDQKLVQ 1831
Query: 3481 LVIQALPSVLINIRTSVQTVV--VGHAVEFECLALGDPKPQVTWSKVGGHL----RPGIV 3534
L + P+ R V+ VG C P+P VTW K G L R +
Sbjct: 1832 LSVLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQAL 1891
Query: 3535 QSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMP--QEVRVPAGSAA 3592
+ G + I +++D G Y C +N AG L VQ P P + V AGS
Sbjct: 1892 RGGQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVPPTFENPKTETVSQVAGSPL 1951
Query: 3593 VFPCIASGYPTPDISWSKLDGSLPPDSRLENNM------LMLPSVRPQDAGTYVCTATNR 3646
V C SG P P ++W L +P +S + + L L ++P AGTY C A N
Sbjct: 1952 VLTCDVSGVPAPTVTW--LKDRMPVESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENT 2009
Query: 3647 QGKVK 3651
Q + +
Sbjct: 2010 QAEAR 2014
Score = 426 bits (1095), Expect = e-118
Identities = 541/2114 (25%), Positives = 786/2114 (37%), Gaps = 290/2114 (13%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQ--GSELHFPSVQPSDAGVYICTCRNLH 1752
+L C G P W E G PV + R + GS L S + +G+Y C
Sbjct: 424 ALECVARGHPSPTLSWHHE-GLPVAESNESRLETDGSVLRLESPGEASSGLYSCVA---- 478
Query: 1753 QSNTSRAELLVTEAPSKPITVTVEEQRSQ-SVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
S A L + P + V E Q + G + C A S SP T+ W L N
Sbjct: 479 SSPAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQA-SGSPVPTIQW--LQN 535
Query: 1812 GKLPTRAMDFNGI--------LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS--- 1860
G+ A + G+ L I +V+L +G + C +N + GTA V+ S
Sbjct: 536 GR---PAEELAGVQVASQGTTLHIDHVELDHSGLFACQATN----EAGTAGAEVEVSVHG 588
Query: 1861 ----GTLSAPVVSIH--------------PPQLTVQPGQLAEFRCSAT-GSPTPTLEWTG 1901
G L P+ H PP V G A + G +P W G
Sbjct: 589 EWAPGVLEVPIGQYHWGXEHHSSFPAACDPP---VHRGWGAHPKPPLVEGWCSPGSLW-G 644
Query: 1902 GPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVS 1961
P G +P + L++ V+ D+ Y C A + AG+ L V P ++
Sbjct: 645 EPTG-IPVAYSLPPP-LQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP--PNIEPG 700
Query: 1962 PERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIATLLIPAITTA 2018
P V +V L C A+GVP ++W K G P + T D L I +
Sbjct: 701 PVNKAVLENASVTLECLASGVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLS 758
Query: 2019 DAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPS-VTEGQTLDLNCVVAGS 2077
DAG Y CVA++ AG+ + R + V PP + + S P V + L C G+
Sbjct: 759 DAGSYRCVASNVAGSTELRYGLRV-----NVPPRITLPPSLPGPVLVNTPVRLTCNATGA 813
Query: 2078 AHAQVTWYRRGGSLPPH----TQVH--GSRLRLPQVSPADSGEYVCRVENGSGPKEASIT 2131
+ W + G + P QV G L L +DSG Y C + G +
Sbjct: 814 PSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVV 873
Query: 2132 VSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGS 2191
+ V H PS I E + V +++ L C ++W K G
Sbjct: 874 LQV----HMPPS----------ILGEELNVSVVANESVALECQSHAMPPPVLSWWKDGRP 919
Query: 2192 LPARHQTHGS----LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
L R H S LL++ + D+G Y C + +G E + + + P+ P+
Sbjct: 920 LEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVWVA----PVFPL 975
Query: 2248 RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH------QVRGSRLYIFQA 2301
R ES + TV EG LSC G +++W K G LP G LY+ QA
Sbjct: 976 R-ESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQA 1034
Query: 2302 SPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPI---RIEPSSSQVAEGQTL 2358
A G Y C SN V G +L I R P+ V +
Sbjct: 1035 QLAQEGTYTCECSN---------VVGNSSQDLQLEVHVPPQIAGPREPPTQVSVVQDGVA 1085
Query: 2359 DLNCVVPGQSHAQVTWHKRG----GSLPVRHQTHGSLLRLYQASPADSGEYVC---RVLG 2411
L C G+ VTW + G L ++ Q G L + +A A +G Y C + G
Sbjct: 1086 TLECNATGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAG 1145
Query: 2412 SSV-PLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTW 2470
+ E SVLV E G + L ++ A L L C G + W
Sbjct: 1146 RAERKFELSVLVPPELIGDLDPL----------TNITAALHSPLTLLCEAMGIPPPAIRW 1195
Query: 2471 HKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSG 2526
+ + + G L++ Q DSG Y C +G + V
Sbjct: 1196 FRGEEPVSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVE------- 1248
Query: 2527 SHSQGVAYPVRIESSSAS----LANGHTLDLNCLVASQAPHTITWYKRGGSLP--SRHQI 2580
V P IE+ + +G T L C V +TW+K G L H I
Sbjct: 1249 -----VLVPPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHI 1303
Query: 2581 V--GSRLRIPQVTPADSGEYVCHVSNGAGSR------ETSLIVTIQGSGSSHVPSVSPPI 2632
G L++ Q + +G Y C +N G + L TI G
Sbjct: 1304 SPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSA------- 1356
Query: 2633 RIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQ------THGSHLRLHQM 2686
TV + L C P ITW K G + THG L++
Sbjct: 1357 ---DEEVTVTVNNPISLICEALAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNA 1411
Query: 2687 SVADSGEYVCRANNNI-DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLD 2745
D+G+Y C N + +A++ V + P + S P + ++ + + TL
Sbjct: 1412 QKEDAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLGEVGVKEVKTKVN----STLT 1467
Query: 2746 LNCVVPGQAHAQVTWHKRGGSLPSHHQTR----GSRLRLHHVSPADSGEYVCRVMGSSGP 2801
L C + W+K G + + + G L++ +DSG Y+C +G
Sbjct: 1468 LECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGE 1527
Query: 2802 LEASVLVTIEASG--------SSAVHV-----PAPGGAPPIRIEPSSSRVAEGQTLDLKC 2848
+ V I+ S+A + A GG R + E L C
Sbjct: 1528 DDQDFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYR------EIVENNPAYLYC 1581
Query: 2849 VVPGQAHAQVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGT--L 2902
+TW++ L A +V G +L++ V ++G YSC+ + G L
Sbjct: 1582 DTNAIPPPDLTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWL 1641
Query: 2903 EASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRG 2962
+LV P G L + + + ASS T+ L C G ++W + G
Sbjct: 1642 HYELLVLTPPVILGDTEE--LVEEVTVNASS-------TVSLQCPALGNPVPTISWLQNG 1692
Query: 2963 --GSLPARHQT--HGSQLRLHLVSPADSGEYVCRAASGPGPEQEA-SFTVTVPPSEGSSY 3017
S R Q G L++ AD+ Y+C A + G ++ + V VPP
Sbjct: 1693 LPFSPSPRLQVLEDGQVLQVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPR----- 1747
Query: 3018 RLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELE--DNVHISPNGSI 3075
+ +D T S C +H P + W +Q L + V + P
Sbjct: 1748 -----IAGLDLEQVTAILNSSVSLPCDVHAHPNP-EVTWYKDSQALSLGEEVFLLPGTHT 1801
Query: 3076 ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP---VWVKVGKAVTL 3132
+ + R S+ G Y C A NA G Q +V LSV PP P GP V V+VG L
Sbjct: 1802 LQLGRARLSDSGMYTCEALNAAGRDQKLVQLSVLVPPAFRQAPRGPQDAVLVRVGDKAVL 1861
Query: 3133 ECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALG 3192
C + P + W + P L QRT L L+I A+ SD G Y C N G
Sbjct: 1862 SCETDALPEPTVTWYK-DGQPLVLAQRTQALRGGQR-LEIQEAQVSDKGLYSCKVSNVAG 1919
Query: 3193 TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE-AGHTATLRCSATGSPAPTIHWSKLRSP 3251
A + + V P + + E + AG L C +G PAPT+ W K R P
Sbjct: 1920 EAVRTFTLTVQV------PPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMP 1973
Query: 3252 LPWQ--HRL--EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY--ATTVP 3305
+ H + G L + R+ +G Y C A + A ++ V P ++ V
Sbjct: 1974 VESSAVHGVVSRGGRLQLSRLQPAQAGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVA 2033
Query: 3306 EHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAAPED 3359
V G+ V+L C A G PP W + GS L R L + D
Sbjct: 2034 REHHVLEGQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGGSLVLKGLRASD 2093
Query: 3360 SGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF 3419
+G Y C N G + V PP A + T+ P G V
Sbjct: 2094 AGAYTCVAHNPAGEDARLHTVNVLVPP----TIKQGADGSGTLVSRP-------GELVTM 2142
Query: 3420 HCAVPSDRGTQLRWFKEGGQLPPGHSV----QDGVLRIQNLDQSCQGTYICQAHGPWGKA 3475
C V + W K+G LP LRI + + G + C A P G A
Sbjct: 2143 VCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSGHTLRISKVQLADAGIFTCVAASPAGVA 2202
Query: 3476 QASAQLVIQALPSVLINIRTSVQTVVV-GHAVEFECLALGDPKPQVTWSKVGGHLRPGIV 3534
+ L +Q +P VL + VVV G VE C A G P P V+W K G L +
Sbjct: 2203 DRNFTLQVQ-VPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKDGEPLLSQSL 2261
Query: 3535 QSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI---SMPQEVRVPAGSA 3591
+ G +++ V D+G Y C A + AG + H L V P I P E+ + G+
Sbjct: 2262 EQGPSLQLEAVGAGDSGTYSCVAVSEAGEARRHFQLTVMEPPHIEDSGQPTELSLTPGAP 2321
Query: 3592 AVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKV- 3650
C A G P P+I+W K +L +RLENN +R +DAG Y C A + G +
Sbjct: 2322 MELLCDAQGTPQPNITWHKDGQAL---TRLENNSRATRVLRVRDAGLYTCLAESPAGAIE 2378
Query: 3651 KAF-AHLQVPERVV 3663
K+F +Q P +V
Sbjct: 2379 KSFRVRVQAPPNIV 2392
Score = 404 bits (1038), Expect = e-111
Identities = 522/2135 (24%), Positives = 786/2135 (36%), Gaps = 292/2135 (13%)
Query: 1676 PLVVEVHPARSIVPQGGSH-SLRCQVSGSPPHYFYWSREDGRPVPSG--TQQRHQGSELH 1732
P V+ A+ ++ G+ L+C SG P W+++ +P G Q + G L
Sbjct: 216 PSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDGQVLR 275
Query: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFI 1792
D G Y C + +R L AP P E +V V +
Sbjct: 276 ITGSHVGDEGRYQCVAFS-PAGQQARDFQLRVHAP--PTIWGSNETGEVAVMEDHLVQLL 332
Query: 1793 CTAKSKSPAYTLVWTRLHNGKLP--TRAMDFNG--ILTIRNVQLSDAGTYVCTGSNMFAM 1848
C A+ P + W + LP T+ + G L + Q SDAG Y C SN
Sbjct: 333 CEARG-VPTPNITWFK-DGALLPTSTKVVYTRGGRQLQLGRAQSSDAGVYTCKASNAVGA 390
Query: 1849 DQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW--TGGPGGQ 1906
+ L V T+ P + G+ C A G P+PTL W G P +
Sbjct: 391 AEKATRLDVYVPPTIEG--AGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHEGLPVAE 448
Query: 1907 L-PAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERT 1965
++ + G +LRL + Y C A S AG+ V + + V P++ V+
Sbjct: 449 SNESRLETDGSVLRLESPGEASSGLYSCVASSPAGEAVLQYSVEVQ--VPPQLLVAEGLG 506
Query: 1966 QVH--AGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE-RTDIATLLIPAITTADAGF 2022
QV G+ + L C+A+G P TI W + G A + + TL I + +G
Sbjct: 507 QVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQGTTLHIDHVELDHSGL 566
Query: 2023 YLCVATSPAGTAQARIQVVV-----------------------LSASDASPPPVKI---E 2056
+ C AT+ AGTA A ++V V S A PPV
Sbjct: 567 FACQATNEAGTAGAEVEVSVHGEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGA 626
Query: 2057 SSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYV 2116
P + EG GS + T SLPP Q+ LR D G Y
Sbjct: 627 HPKPPLVEG------WCSPGSLWGEPTGIPVAYSLPPPLQIEKVDLR-------DEGIYT 673
Query: 2117 CRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVP 2176
C N +G + + + VL VP + P P + V E ++ L C+
Sbjct: 674 CAATNLAGESKREVALKVL-----------VPPNIEP---GPVNKAVLENASVTLECLAS 719
Query: 2177 GQAHAQVTWHKRGGSLPARH------QTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEAS 2230
G V+W K G P G +LR+ Q +D+G Y C +G E
Sbjct: 720 GVPPPDVSWFK--GHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE-- 775
Query: 2231 VLVTIEASVIPG-PIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL---- 2285
+ + +V P +PP S V + L+C G + W K G +
Sbjct: 776 LRYGLRVNVPPRITLPP----SLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAG 831
Query: 2286 -PARHQVRGSR-LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPI 2343
P G R L + A +D+G+Y C + V+ G ++ I
Sbjct: 832 TPGLQVFPGGRVLTLASARASDSGRYSC---------VAVSAVGEDRQDVVLQVHMPPSI 882
Query: 2344 RIEPSSSQVAEGQTLDLNCVVPGQSHAQ----VTWHKRGGSLPVRHQTHGS----LLRLY 2395
E + V +++ L C QSHA ++W K G L R H S LL++
Sbjct: 883 LGEELNVSVVANESVALEC----QSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVD 938
Query: 2396 QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLD 2455
+A D+G Y C L + E + + A P ES + V EG
Sbjct: 939 RADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLR--------ESHTLTVREGHPTS 990
Query: 2456 LNCLVAGQAHAQVTWHKRGGSLPARH------QVHGSRLRLLQVTPADSGEYVC---RVV 2506
L+C G +++W K G LP G L L Q A G Y C VV
Sbjct: 991 LSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVV 1050
Query: 2507 GSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTIT 2566
G+S +Q+ + V + +++G R + S+ L C + P T+T
Sbjct: 1051 GNS-SQDLQLEVHVPPQIAGP---------REPPTQVSVVQDGVATLECNATGKPPPTVT 1100
Query: 2567 WYKR----GGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS 2622
W + G L + Q G L + + A +G Y C N AG E +++
Sbjct: 1101 WERDGQPVGAELGLQLQNQGQSLHVERAQAAHTGRYSCVAENLAGRAERKFELSV----- 1155
Query: 2623 SHVPSVSPPIRIESSSP----TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH- 2677
+ PP I P T L L C P I W++ + T+
Sbjct: 1156 -----LVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFRGEEPVSPGEDTYL 1210
Query: 2678 ---GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESS 2734
G L++ Q DSG Y C A+N + + V PS + I+
Sbjct: 1211 LAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEV---LVPPSIENEDLEEVIK-- 1265
Query: 2735 SSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSL---PSHH-QTRGSRLRLHHVSPADSGE 2790
V +G+T L C V G ++TW K G L +HH G L++ + + +G
Sbjct: 1266 ---VLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGH 1322
Query: 2791 YVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVV 2850
Y C + G +++ + + GGA E + V + L C
Sbjct: 1323 YSCIAANAVGEKTKHFQLSVLLAPTIL------GGAEDSADEEVT--VTVNNPISLICEA 1374
Query: 2851 PGQAHAQVTWHKRGGNLPARHQV------HGPLLRLNQVSPADSGEYSCQVTGSSG---- 2900
+TW K G A + HG L++ D+G+Y+C VT G
Sbjct: 1375 LAFPSPNITWMKDGAPFEASRNIQLLPGTHG--LQILNAQKEDAGQYTCVVTNELGEAVK 1432
Query: 2901 TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK 2960
VL+ S P+ G+ + + + +S TL L C + WYK
Sbjct: 1433 NYHVEVLIPPSISKDDPLGEVGVKE-VKTKVNS-------TLTLECESWAVPPPTIRWYK 1484
Query: 2961 RGGSLPARHQT----HGSQLRLHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPP--SE 3013
G + + G L++ +DSG Y+C A + G +Q+ + + VPP +
Sbjct: 1485 DGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQDFNVLIQVPPMFQK 1544
Query: 3014 GSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAA----------PISLEWKTRNQEL 3063
+ ++S + + +G ++ ++ + A P L W +Q L
Sbjct: 1545 VGDFSAAFEILSREEEA----RGGVTEYREIVENNPAYLYCDTNAIPPPDLTWYREDQPL 1600
Query: 3064 E--DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE-- 3119
D V + G ++ I R N G Y C ASN G L V PP + E
Sbjct: 1601 SAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTPPVILGDTEEL 1660
Query: 3120 -GPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPS 3178
V V V+L+C + G P + W + + P R L D VLQ+S+A+ +
Sbjct: 1661 VEEVTVNASSTVSLQCPALGNPVPTISWLQ-NGLPFSPSPRLQVLEDGQ-VLQVSTAEVA 1718
Query: 3179 DAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGS 3238
DA +Y+C+A+N G+A+K + V G + ++T + +L C
Sbjct: 1719 DAASYMCVAENQAGSAEKLFTLRVQVPPRIAG-----LDLEQVTAILNSSVSLPCDVHAH 1773
Query: 3239 PAPTIHWSKLRSPLPWQHR---LEG-DTLIIPRVAQQDSGQYICNATSPAGHAEATIILH 3294
P P + W K L L G TL + R DSG Y C A + AG + + L
Sbjct: 1774 PNPEVTWYKDSQALSLGEEVFLLPGTHTLQLGRARLSDSGMYTCEALNAAGRDQKLVQLS 1833
Query: 3295 VESPPYATTVP----EHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL----PGRATAR 3346
V PP P + V+ G+ L C P T W + G L +A
Sbjct: 1834 VLVPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRG 1893
Query: 3347 NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTP 3406
+ L + A D G Y C+V+N G A L VQ P P P +
Sbjct: 1894 GQRLEIQEAQVSDKGLYSCKVSNVAGEAVRTFTLTVQVP---------PTFENPKTETVS 1944
Query: 3407 QLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV------LRIQNLDQSC 3460
Q+ G+ + C V + W K+ ++P S GV L++ L +
Sbjct: 1945 QV----AGSPLVLTCDVSGVPAPTVTWLKD--RMPVESSAVHGVVSRGGRLQLSRLQPAQ 1998
Query: 3461 QGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQV 3520
GTY C A +A+ + + P + + V+ G V +C A G P P V
Sbjct: 1999 AGTYTCVAENTQAEARKDFVVAVLVAPRIRSSGVAREHHVLEGQEVRLDCEADGQPPPDV 2058
Query: 3521 TWSK--------VGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLV 3572
W K +G HLR GG + + + +DAG Y C A N AG + V
Sbjct: 2059 AWLKDGSPLGQDMGPHLR--FYLDGGSLVLKGLRASDAGAYTCVAHNPAGEDARLHTVNV 2116
Query: 3573 QALPQISMPQE-----VRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL----EN 3623
P I + V P G C G P +SW K LP R
Sbjct: 2117 LVPPTIKQGADGSGTLVSRP-GELVTMVCPVRGSPPIHVSWLKDGLPLPLSQRTLLHGSG 2175
Query: 3624 NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
+ L + V+ DAG + C A + G LQV
Sbjct: 2176 HTLRISKVQLADAGIFTCVAASPAGVADRNFTLQV 2210
Score = 385 bits (989), Expect = e-106
Identities = 466/1838 (25%), Positives = 717/1838 (39%), Gaps = 265/1838 (14%)
Query: 1977 CRAAGVPSATITWRKEGGSLP--PQARSERTDIATLLIPAITTADAGFYLCVATSPAGTA 2034
C G P +TWRK S P Q + +L + +++ AD+G Y C AT+ G+
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGST 83
Query: 2035 QARIQVVVLSASDASPPPVKIESSSPSVT--EGQTLDLNCVVAGSAHAQVTWYRRG---- 2088
R ++VV PP ++ + +V+ GQ+L L C G ++ W +
Sbjct: 84 SRRAKLVVY-----VPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVG 138
Query: 2089 --------------GSLPPHTQV-HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVS 2133
G + H + G L P++ P SG + G + + +
Sbjct: 139 VPLGWAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRR--GAQAGGSAQTKAPWXA 196
Query: 2134 VLHGTHSGPS----YTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK-R 2188
L G P+ P P S +A G ++L C G QV W K R
Sbjct: 197 GLAGFEQFPTPHAFSPPAPPSVLGAGAAQEVLGLA-GADVELQCWTSGVPTPQVEWTKDR 255
Query: 2189 GGSLPA----RHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPI 2244
LP + Q G +LR+ D G Y C +G + + A
Sbjct: 256 QPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHA------- 308
Query: 2245 PPV---RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV---RGSR-LY 2297
PP E+ V E + L C G +TW+K G LP +V RG R L
Sbjct: 309 PPTIWGSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQ 368
Query: 2298 IFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQT 2357
+ +A +DAG Y C+ASN + A+ T AG P + G+
Sbjct: 369 LGRAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGG------RPYVVKAVAGRP 422
Query: 2358 LDLNCVVPGQSHAQVTWHKRGGSLPV------RHQTHGSLLRLYQASPADSGEYVCRVLG 2411
+ L CV G ++WH G LPV R +T GS+LRL A SG Y C +
Sbjct: 423 VALECVARGHPSPTLSWHHEG--LPVAESNESRLETDGSVLRLESPGEASSGLYSC--VA 478
Query: 2412 SSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAE--GQTLDLNCLVAGQAHAQVT 2469
SS EA + ++E + V P + + QV GQ L+L C +G +
Sbjct: 479 SSPAGEAVLQYSVE-------VQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQ 531
Query: 2470 WHKRGGSLPARHQV------HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQR 2523
W + G PA G+ L + V SG + C+ +GT A V V++
Sbjct: 532 WLQNG--RPAEELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH-- 587
Query: 2524 LSGSHSQGV------AYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL--- 2574
G + GV Y E S+ A A P + + GSL
Sbjct: 588 --GEWAPGVLEVPIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE 645
Query: 2575 PSRHQIVGS---RLRIPQVTPADSGEYVCHVSNGAG--SRETSLIVTIQGSGSSHVPSVS 2629
P+ + S L+I +V D G Y C +N AG RE +L V + P++
Sbjct: 646 PTGIPVAYSLPPPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVP-------PNIE 698
Query: 2630 P-PIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS----RHQTHGSHLRLH 2684
P P+ + V+E ++ L C+ + P ++W+K + S G LR+
Sbjct: 699 PGPV-----NKAVLENASVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIE 753
Query: 2685 QMSVADSGEYVCRANNNIDALEA--SIVISVSPSAG-SPSAPGSSMPIRIESSSSHVAEG 2741
Q ++D+G Y C A+N + E + ++V P PS PG P+ + +
Sbjct: 754 QAQLSDAGSYRCVASNVAGSTELRYGLRVNVPPRITLPPSLPG---PVLVNT-------- 802
Query: 2742 ETLDLNCVVPGQAHAQVTWHKRGGSL-----PSHHQTRGSR-LRLHHVSPADSGEYVCRV 2795
+ L C G + W K G + P G R L L +DSG Y C
Sbjct: 803 -PVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVA 861
Query: 2796 MGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAH 2855
+ + G V++ VH+P P I E + V +++ L+C
Sbjct: 862 VSAVGEDRQDVVL--------QVHMP-----PSILGEELNVSVVANESVALECQSHAMPP 908
Query: 2856 AQVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE 2911
++W K G L R VH LL++++ D+G Y+C+ +G E + +
Sbjct: 909 PVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAGRSEKHYNLNVW 968
Query: 2912 PSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARH-- 2969
+ P+ E+ + V EG L+C G +++W K G LP
Sbjct: 969 VAPVFPLR----------ESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAG 1018
Query: 2970 ----QTHGSQLRLHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSEGSSYRLRSPVI 3024
G L L A G Y C ++ G Q+ V VPP R P
Sbjct: 1019 LQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVGNSSQDLQLEVHVPPQIAGP---REP-- 1073
Query: 3025 SIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNGSIITIVGTR 3082
P +V Q A+ +C G P ++ W+ Q + E + + G + + +
Sbjct: 1074 ---PTQVSVVQDGVATLECNA-TGKPPPTVTWERDGQPVGAELGLQLQNQGQSLHVERAQ 1129
Query: 3083 PSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV--SVLPEGPVWVKVGKAVTLECVSAGEP 3140
++ G Y CVA N G A+ LSV PP + + P + + +TL C + G P
Sbjct: 1130 AAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIP 1189
Query: 3141 RSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK--QV 3198
+ RW R P + TY L+ +L+++ + D+G Y CLA N G A++ V
Sbjct: 1190 PPAIRWFR-GEEPVSPGEDTY-LLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSV 1247
Query: 3199 EVIVDTGAMAPGAPQVQAEEAELTVEA--GHTATLRCSATGSPAPTIHWSKLRSPLPW-- 3254
EV+V P ++ E+ E ++ G TA L C+ TG P P + W K PL
Sbjct: 1248 EVLV--------PPSIENEDLEEVIKVLDGQTAHLMCNVTGHPQPKLTWFKDGRPLARGD 1299
Query: 3255 QHRLEGDTLIIP--RVAQQDSGQYICNATSPAGHAEATIILHVESPP-----YATTVPEH 3307
H + D +++ + +G Y C A + G L V P + E
Sbjct: 1300 AHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHFQLSVLLAPTILGGAEDSADEE 1359
Query: 3308 ASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL------LHFERAAPEDSG 3361
+V + L C A P W + G+ P A+ +L L A ED+G
Sbjct: 1360 VTVTVNNPISLICEALAFPSPNITWMKDGA--PFEASRNIQLLPGTHGLQILNAQKEDAG 1417
Query: 3362 RYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHC 3421
+Y C VTN++G A + V PP + P G +V +TK + +++ C
Sbjct: 1418 QYTCVVTNELGEAVKNYHVEVLIPPSI--SKDDPLGEVGVKEV----KTK-VNSTLTLEC 1470
Query: 3422 AVPSDRGTQLRWFKEGGQLPPGHSVQ----DGVLRIQNLDQSCQGTYICQAHGPWGKAQA 3477
+ +RW+K+G + P +Q +L+IQ S G Y+C A G+
Sbjct: 1471 ESWAVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVATNVAGEDDQ 1530
Query: 3478 SAQLVIQALP--------SVLINIR----------TSVQTVVVGHAVEFECLALGDPKPQ 3519
++IQ P S I T + +V + C P P
Sbjct: 1531 DFNVLIQVPPMFQKVGDFSAAFEILSREEEARGGVTEYREIVENNPAYLYCDTNAIPPPD 1590
Query: 3520 VTWSKVGGHLRPG----IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL 3575
+TW + L G ++Q G V++I V +AG+Y C A+N G H LLV
Sbjct: 1591 LTWYREDQPLSAGDEVSVLQGGRVLQIPLVRAENAGRYSCKASNEVGEDWLHYELLVLTP 1650
Query: 3576 PQI-----SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL----ENNML 3626
P I + +EV V A S C A G P P ISW + P RL + +L
Sbjct: 1651 PVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLEDGQVL 1710
Query: 3627 MLPSVRPQDAGTYVCTATNRQGKVKAF--AHLQVPERV 3662
+ + DA +Y+C A N+ G + +QVP R+
Sbjct: 1711 QVSTAEVADAASYMCVAENQAGSAEKLFTLRVQVPPRI 1748
Score = 254 bits (649), Expect = 1e-66
Identities = 290/1120 (25%), Positives = 436/1120 (38%), Gaps = 124/1120 (11%)
Query: 2651 CVVARQPQAIITWYKRGGSLPSRHQT------HGSHLRLHQMSVADSGEYVCRANNNIDA 2704
C P+ +TW K S P Q GS L L +S ADSG+Y C+A N + +
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEGS-LFLASVSPADSGDYECQATNEVGS 82
Query: 2705 L--EASIVISVSPS-------AGSPSAPGSSMPIRIESSSSHVAEGETL-DLNCVVPGQA 2754
A +V+ V PS A G S+ + +++ V E L D V
Sbjct: 83 TSRRAKLVVYVPPSIREDGRKANVSGMAGQSLTLECDANGFPVPEIVWLKDAQLVGVPLG 142
Query: 2755 HAQVTWHKRGGSLPSHH-QTRGSRLRLHHVSPADSGEYVCRVMGSS---GPLEASVLVTI 2810
A W G + H G L + P SG + GS+ P A +
Sbjct: 143 WAGYGWDLGWGQVGGHRLLDEGQSLHFPRIQPGRSGRRGAQAGGSAQTKAPWXAGLAGFE 202
Query: 2811 EASGSSAVHVPAPGGAPPIRIEPSSSRV--AEGQTLDLKCVVPGQAHAQVTWHK-RGGNL 2867
+ A PAP P + ++ V G ++L+C G QV W K R L
Sbjct: 203 QFPTPHAFSPPAP---PSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVL 259
Query: 2868 PA----RHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGL 2923
P + Q G +LR+ D G Y C +G + + +P I
Sbjct: 260 PGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVH--APPTIWGSN- 316
Query: 2924 AQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR----HQTHGSQLRLH 2979
E V E + L C G +TW+K G LP + G QL+L
Sbjct: 317 ------ETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLG 370
Query: 2980 LVSPADSGEYVCRAASGPGPEQEAS-FTVTVPPS-EGSSYRLRSPVISIDPPSSTVQQGQ 3037
+D+G Y C+A++ G ++A+ V VPP+ EG+ R P G+
Sbjct: 371 RAQSSDAGVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGR---------PYVVKAVAGR 421
Query: 3038 DASFKCLIHDGAAPISLEWKTRNQELEDN--VHISPNGSIITIVGTRPSNHGTYRCVASN 3095
+ +C+ +P +L W + ++ + +GS++ + ++ G Y CVAS+
Sbjct: 422 PVALECVARGHPSP-TLSWHHEGLPVAESNESRLETDGSVLRLESPGEASSGLYSCVASS 480
Query: 3096 AYGVAQSVVNLSVHGPPTVSVLPE-GPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPA 3154
G A ++ V PP + V G V VG+ + L C ++G P + +W + + PA
Sbjct: 481 PAGEAVLQYSVEVQVPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQ-NGRPA 539
Query: 3155 KLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV 3214
+ E + L I + +G + C A N GTA +VEV V G APG +V
Sbjct: 540 E-ELAGVQVASQGTTLHIDHVELDHSGLFACQATNEAGTAGAEVEVSVH-GEWAPGVLEV 597
Query: 3215 QAEEAELTVEAGHTATLRCS---------------ATGSPAPTIHWSKLRSPLPWQHRLE 3259
+ E + C G +P W + + +P + L
Sbjct: 598 PIGQYHWGXEHHSSFPAACDPPVHRGWGAHPKPPLVEGWCSPGSLWGE-PTGIPVAYSLP 656
Query: 3260 GDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQ 3319
L I +V +D G Y C AT+ AG ++ + L V PP P + +V +V L+
Sbjct: 657 -PPLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPPNIEPGPVNKAVLENASVTLE 715
Query: 3320 CLAHGTPPLTFQWSR----VGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAE 3375
CLA G PP W + V S + + +L E+A D+G YRC +N GS E
Sbjct: 716 CLASGVPPPDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTE 775
Query: 3376 AFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFK 3435
L V PP S+P P + TP V C L W K
Sbjct: 776 LRYGLRVNVPPRITLPPSLPG---PVLVNTP----------VRLTCNATGAPSPTLMWLK 822
Query: 3436 EGGQL----PPGHSVQDG--VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSV 3489
+G + PG V G VL + + S G Y C A G+ + L + PS+
Sbjct: 823 DGNPVSPAGTPGLQVFPGGRVLTLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSI 882
Query: 3490 L---INIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHL--RPGIVQSG--GVVRI 3542
L +N+ +VV +V EC + P P ++W K G L RPG+ S ++++
Sbjct: 883 LGEELNV-----SVVANESVALECQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQV 937
Query: 3543 AHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQE--VRVPAGSAAVFPCIASG 3600
++ DAG Y C A N AG ++ H L V P + + + V G C G
Sbjct: 938 DRADVWDAGHYTCEALNQAGRSEKHYNLNVWVAPVFPLRESHTLTVREGHPTSLSCECRG 997
Query: 3601 YPTPDISWSKLDGSLPPDS------RLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFA 3654
P P ISW K LP + +L L + GTY C +N G +
Sbjct: 998 VPFPKISWRKDGQPLPGEGAGLQHVSAVGRLLYLGQAQLAQEGTYTCECSNVVG--NSSQ 1055
Query: 3655 HLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRP 3694
LQ+ V P + ++D E T +P
Sbjct: 1056 DLQLEVHVPPQIAGPREPPTQVSVVQDGVATLECNATGKP 1095
Score = 51.6 bits (122), Expect = 2e-05
Identities = 37/115 (32%), Positives = 49/115 (42%), Gaps = 4/115 (3%)
Query: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVK 470
PP ++ S QT C A GVP P+++WR + +P PR G+L I+ V
Sbjct: 2488 PP--AVNVSVNQTALLPCQADGVPAPLVSWRKD--RVPLDPRSPRFEILPEGSLRIQPVL 2543
Query: 471 ESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFG 525
D G Y C A N+ G D + P P P H+ A LPC G
Sbjct: 2544 AQDAGHYLCLASNSAGSDRQGRDLRVLEPPAIAPSPSNLTLTAHTPALLPCEASG 2598
Score = 48.1 bits (113), Expect = 2e-04
Identities = 32/95 (33%), Positives = 45/95 (47%), Gaps = 2/95 (2%)
Query: 1674 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRH-QGSELH 1732
Q+ V +V P V G +LRCQ +G P W + G+P+ + + R L
Sbjct: 3115 QSAPVFQVEPQDMTVRSGDDVALRCQATGEPTPTIEW-LQAGQPLRASRRLRTLPDGSLW 3173
Query: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP 1767
+V+ DAG Y C NL S T+RA L+V P
Sbjct: 3174 LENVETGDAGTYDCVAHNLLGSATARAFLVVRGEP 3208
Score = 45.1 bits (105), Expect = 0.002
Identities = 27/63 (42%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 424 VTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMN 483
V C A GVPTP I W + +P+ +V T GGR L + + SD G YTC+A N
Sbjct: 329 VQLLCEARGVPTPNITWFKDGALLPTSTKVVYT-RGGR-QLQLGRAQSSDAGVYTCKASN 386
Query: 484 ARG 486
A G
Sbjct: 387 AVG 389
Score = 45.1 bits (105), Expect = 0.002
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 2/82 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP P E++ G + TC GVP P + W + + S V S GGR
Sbjct: 1931 VPPTFENPKTETVSQVAGSPLVLTCDVSGVPAPTVTWLKDRMPVESSAVHGVVSRGGR-- 1988
Query: 464 LIIRDVKESDQGAYTCEAMNAR 485
L + ++ + G YTC A N +
Sbjct: 1989 LQLSRLQPAQAGTYTCVAENTQ 2010
Score = 42.0 bits (97), Expect = 0.013
Identities = 27/83 (32%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP + P +VT C+A GVP P ++W + S VTV+ +G
Sbjct: 693 VPPNIEPGPVNKAVLENA-SVTLECLASGVPPPDVSWFKGHQPVSSWMGVTVSVDG--RV 749
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L I + SD G+Y C A N G
Sbjct: 750 LRIEQAQLSDAGSYRCVASNVAG 772
Score = 42.0 bits (97), Expect = 0.013
Identities = 26/85 (30%), Positives = 38/85 (44%), Gaps = 4/85 (4%)
Query: 404 MPPQVV--TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR 461
+PP+++ P +I A+ +T C A+G+P P I W G P P G
Sbjct: 1157 VPPELIGDLDPLTNITAALHSPLTLLCEAMGIPPPAIRWFR--GEEPVSPGEDTYLLAGG 1214
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
L + +E D G Y+C A N G
Sbjct: 1215 WMLKMTQTQEQDSGLYSCLASNEAG 1239
Score = 40.8 bits (94), Expect = 0.030
Identities = 25/84 (29%), Positives = 38/84 (45%), Gaps = 2/84 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRG 462
+PP++ PP V TC A G P+P + W + + P+ GGR
Sbjct: 784 VPPRITLPPSLPGPVLVNTPVRLTCNATGAPSPTLMWLKDGNPVSPAGTPGLQVFPGGR- 842
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
L + + SD G Y+C A++A G
Sbjct: 843 VLTLASARASDSGRYSCVAVSAVG 866
Score = 40.8 bits (94), Expect = 0.030
Identities = 26/88 (29%), Positives = 38/88 (43%), Gaps = 11/88 (12%)
Query: 408 VVTPPR---------ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSE 458
V+TPP E + + TV+ C A+G P P I+W N PR+ V +
Sbjct: 1647 VLTPPVILGDTEELVEEVTVNASSTVSLQCPALGNPVPTISWLQNGLPFSPSPRLQVLED 1706
Query: 459 GGRGTLIIRDVKESDQGAYTCEAMNARG 486
G L + + +D +Y C A N G
Sbjct: 1707 G--QVLQVSTAEVADAASYMCVAENQAG 1732
Score = 40.0 bits (92), Expect = 0.051
Identities = 29/106 (27%), Positives = 44/106 (41%), Gaps = 5/106 (4%)
Query: 384 ASFHCDEESDCPDRSDEFGC---MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINW 440
AS+ C E+ F +PP++ E + A +V+ C P P + W
Sbjct: 1721 ASYMCVAENQAGSAEKLFTLRVQVPPRIAGLDLEQVTAILNSSVSLPCDVHAHPNPEVTW 1780
Query: 441 RLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ + V + G TL + + SD G YTCEA+NA G
Sbjct: 1781 YKDSQALSLGEEVFLLP--GTHTLQLGRARLSDSGMYTCEALNAAG 1824
Score = 40.0 bits (92), Expect = 0.051
Identities = 39/135 (28%), Positives = 54/135 (40%), Gaps = 5/135 (3%)
Query: 405 PPQVVTP--PRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
PP +V P PR + + GQ V C P P I W + G + T E GR
Sbjct: 2388 PPNIVGPRGPRFVVGLAPGQLV-LECSVEAEPAPKITWHRD-GIVLQEDAHTQFPERGR- 2444
Query: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCF 522
L ++ + +D G Y+C A NA G + VP P + A LPC
Sbjct: 2445 FLQLQALSTADSGDYSCTARNAAGSTSVAFRVEIHTVPTIRSGPPAVNVSVNQTALLPCQ 2504
Query: 523 CFGITSVCQSTRRFR 537
G+ + S R+ R
Sbjct: 2505 ADGVPAPLVSWRKDR 2519
Score = 39.7 bits (91), Expect = 0.067
Identities = 23/68 (33%), Positives = 34/68 (50%), Gaps = 4/68 (5%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSH--PRVTVTSEGGRGTLIIRDVKESDQGAYT 478
GQ V C A G P P + W + + P + +GG +L+++ ++ SD GAYT
Sbjct: 2041 GQEVRLDCEADGQPPPDVAWLKDGSPLGQDMGPHLRFYLDGG--SLVLKGLRASDAGAYT 2098
Query: 479 CEAMNARG 486
C A N G
Sbjct: 2099 CVAHNPAG 2106
Score = 38.9 bits (89), Expect = 0.11
Identities = 34/115 (29%), Positives = 46/115 (40%), Gaps = 5/115 (4%)
Query: 408 VVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIR 467
VV P ++A + V C A G+P P I W+ ++ + V G L I
Sbjct: 2758 VVKPLPSVVRAVAEEEVLLPCEASGIPRPTITWQKEGLNVATGVSTQVLP---GGQLRIA 2814
Query: 468 DVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQ-RGPCPDGHFYLEHSAACLPC 521
D G Y C A N+ G G V+++ P PD E S A LPC
Sbjct: 2815 HASPEDAGNYLCIAKNSAGSAMGKTRLVVQVPPVIENGLPD-LSTTEGSHAFLPC 2868
Score = 38.1 bits (87), Expect = 0.19
Identities = 22/73 (30%), Positives = 32/73 (43%), Gaps = 2/73 (2%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
+ ++ T+T C + VP P I W + + R+ V EG L I+ + SD
Sbjct: 1456 KEVKTKVNSTLTLECESWAVPPPTIRWYKDGQPVTPSSRLQVLGEG--RLLQIQPTQVSD 1513
Query: 474 QGAYTCEAMNARG 486
G Y C A N G
Sbjct: 1514 SGRYLCVATNVAG 1526
Score = 37.7 bits (86), Expect = 0.25
Identities = 26/93 (27%), Positives = 42/93 (45%), Gaps = 8/93 (8%)
Query: 396 DRSDEFGCMPPQVVTPP--RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRV 453
DR+ P V+ P + + RG V C A GVP P+++W + P +
Sbjct: 2203 DRNFTLQVQVPPVLEPVEFQNDVVVVRGSLVELPCEARGVPLPLVSWMKD-----GEPLL 2257
Query: 454 TVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ + E G +L + V D G Y+C A++ G
Sbjct: 2258 SQSLEQG-PSLQLEAVGAGDSGTYSCVAVSEAG 2289
Score = 37.4 bits (85), Expect = 0.33
Identities = 22/61 (36%), Positives = 27/61 (44%), Gaps = 5/61 (8%)
Query: 428 CVAIGVPTPIINWRLNWGHIPSH--PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNAR 485
C G P P + WR P H P V V EG +L + V +D G Y C+A N
Sbjct: 24 CGTHGTPKPQVTWRKGPSSEPLHGQPGVAVLEEG---SLFLASVSPADSGDYECQATNEV 80
Query: 486 G 486
G
Sbjct: 81 G 81
Score = 37.4 bits (85), Expect = 0.33
Identities = 27/84 (32%), Positives = 35/84 (41%), Gaps = 3/84 (3%)
Query: 404 MPPQV-VTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
+PPQ+ V + GQ + C A G P P I W N V V S+G
Sbjct: 495 VPPQLLVAEGLGQVTTIVGQPLELPCQASGSPVPTIQWLQNGRPAEELAGVQVASQG--T 552
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
TL I V+ G + C+A N G
Sbjct: 553 TLHIDHVELDHSGLFACQATNEAG 576
Score = 37.4 bits (85), Expect = 0.33
Identities = 22/83 (26%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
MPP ++ ++ ++V C + +P P+++W + P PR V +
Sbjct: 878 MPPSILGEEL-NVSVVANESVALECQSHAMPPPVLSWWKDGR--PLEPRPGVHLSADKAL 934
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L + D G YTCEA+N G
Sbjct: 935 LQVDRADVWDAGHYTCEALNQAG 957
Score = 37.0 bits (84), Expect = 0.43
Identities = 26/81 (32%), Positives = 37/81 (45%), Gaps = 4/81 (4%)
Query: 409 VTPPRES--IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSH-PRVTVTSEGGRGTLI 465
V P RES + G + +C GVP P I+WR + +P + S GR L
Sbjct: 972 VFPLRESHTLTVREGHPTSLSCECRGVPFPKISWRKDGQPLPGEGAGLQHVSAVGR-LLY 1030
Query: 466 IRDVKESDQGAYTCEAMNARG 486
+ + + +G YTCE N G
Sbjct: 1031 LGQAQLAQEGTYTCECSNVVG 1051
Score = 36.2 bits (82), Expect = 0.74
Identities = 22/82 (26%), Positives = 36/82 (43%), Gaps = 4/82 (4%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRGTL 464
P V+ + + G C A G P P I W + + + + T+ G L
Sbjct: 2846 PPVIENGLPDLSTTEGSHAFLPCKARGSPEPNITWDKDGQPVSGAEGKFTIQPSG---EL 2902
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
++++++ D G YTC A NA G
Sbjct: 2903 LVKNLEGQDAGTYTCTAENAVG 2924
Score = 36.2 bits (82), Expect = 0.74
Identities = 21/66 (31%), Positives = 29/66 (43%), Gaps = 3/66 (4%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G V C A G PTP I W + + R+ + G+L + +V+ D G Y C
Sbjct: 3132 GDDVALRCQATGEPTPTIEWLQAGQPLRASRRLRTLPD---GSLWLENVETGDAGTYDCV 3188
Query: 481 AMNARG 486
A N G
Sbjct: 3189 AHNLLG 3194
Score = 35.4 bits (80), Expect = 1.3
Identities = 27/121 (22%), Positives = 41/121 (33%), Gaps = 2/121 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P + + + V TC + G+P P ++W + + S G L
Sbjct: 2665 PPTIADDQTDFTVTMMAPVVLTCHSTGIPAPTVSWSKAGAQLGARGSGYRVSPSG--ALE 2722
Query: 466 IRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFCFG 525
I G YTC A N+ G+ ++ P P P + LPC G
Sbjct: 2723 IGQALPIHAGRYTCSARNSAGVAHKHVFLTVQASPVVKPLPSVVRAVAEEEVLLPCEASG 2782
Query: 526 I 526
I
Sbjct: 2783 I 2783
Score = 35.4 bits (80), Expect = 1.3
Identities = 22/66 (33%), Positives = 27/66 (40%), Gaps = 4/66 (6%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G + C A G PTP I W +N + V+ + G TL V D G Y C
Sbjct: 2952 GDRLWLRCAARGSPTPRIGWTVNDRPVTE----GVSEQDGGSTLQRAAVSREDSGTYVCW 3007
Query: 481 AMNARG 486
A N G
Sbjct: 3008 AENRVG 3013
Score = 35.0 bits (79), Expect = 1.6
Identities = 22/85 (25%), Positives = 37/85 (43%), Gaps = 4/85 (4%)
Query: 404 MPPQVVTPPRESIQASRGQ--TVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR 461
+PPQ+ P Q S Q T C A G P P + W + + + + + ++G
Sbjct: 1063 VPPQIAGPREPPTQVSVVQDGVATLECNATGKPPPTVTWERDGQPVGAELGLQLQNQG-- 1120
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
+L + + + G Y+C A N G
Sbjct: 1121 QSLHVERAQAAHTGRYSCVAENLAG 1145
Score = 35.0 bits (79), Expect = 1.6
Identities = 21/86 (24%), Positives = 37/86 (43%), Gaps = 5/86 (5%)
Query: 404 MPP---QVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG 460
+PP Q P++++ G +C +P P + W + + R G
Sbjct: 1836 VPPAFRQAPRGPQDAVLVRVGDKAVLSCETDALPEPTVTWYKDGQPLVLAQRTQALRGGQ 1895
Query: 461 RGTLIIRDVKESDQGAYTCEAMNARG 486
R L I++ + SD+G Y+C+ N G
Sbjct: 1896 R--LEIQEAQVSDKGLYSCKVSNVAG 1919
Score = 34.7 bits (78), Expect = 2.1
Identities = 21/59 (35%), Positives = 28/59 (47%), Gaps = 8/59 (13%)
Query: 3848 CRDRP-CQNGGQCHDSESSSYVCVCPAGF----TGSRCEHSQALHCHPEACGPDATCVN 3901
CR R CQ+ C ++E S Y C+CPAG+ +G C+ CGP C N
Sbjct: 3682 CRVRNLCQHA--CRNTEGS-YQCLCPAGYRLLPSGKNCQDINECEEESIECGPGQMCFN 3737
Score = 33.9 bits (76), Expect = 3.7
Identities = 24/84 (28%), Positives = 34/84 (40%), Gaps = 4/84 (4%)
Query: 405 PPQVV-TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRG 462
PP V+ + + G V C GVPTP + W + + P P + V +G
Sbjct: 215 PPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVEWTKDRQPVLPGGPHLQVQEDG--Q 272
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
L I D+G Y C A + G
Sbjct: 273 VLRITGSHVGDEGRYQCVAFSPAG 296
Score = 32.7 bits (73), Expect = 8.2
Identities = 18/71 (25%), Positives = 32/71 (45%), Gaps = 2/71 (2%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
++A G+ V CVA G P+P ++W + + ++G L + E+ G
Sbjct: 415 VKAVAGRPVALECVARGHPSPTLSWHHEGLPVAESNESRLETDG--SVLRLESPGEASSG 472
Query: 476 AYTCEAMNARG 486
Y+C A + G
Sbjct: 473 LYSCVASSPAG 483
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 517 bits (1332), Expect = e-146
Identities = 538/2133 (25%), Positives = 825/2133 (38%), Gaps = 308/2133 (14%)
Query: 1682 HPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPV--PSGTQQRHQGSELHFPSVQPS 1739
HP IV +G S SL C+V G PP W + DG P+ G + +G L ++ S
Sbjct: 2298 HPTEIIVTRGKSISLECEVQGIPPPTVTWMK-DGHPLIKAKGVEILDEGHILQLKNIHVS 2356
Query: 1740 DAGVYICTCRNLHQSNTSRAELLVTEAPS------KPITVTVEEQRSQSVRPGADVTFIC 1793
D G Y+C N+ + +L V PS P ++V E+ S V+ C
Sbjct: 2357 DTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNS--------VSLTC 2408
Query: 1794 TAKSKSPAYTLVWTR------LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFA 1847
A S P ++ W + L N R + +L + + DAG Y C N
Sbjct: 2409 EA-SGIPLPSITWFKDGWPVSLSNS---VRILSGGRMLRLMQTTMEDAGQYTCVVRNAAG 2464
Query: 1848 MDQ---GTATL---HVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW-- 1899
++ G + L H+ TL + V+ Q C TG+P P + W
Sbjct: 2465 EERKIFGLSVLVPPHIVGENTLE---------DVKVKEKQSVTLTCEVTGNPVPEITWHK 2515
Query: 1900 TGGPGGQLPAKAQIHGG-ILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGG---GG 1955
G P + A I GG L++ V+ +Y C A S AG + L+V G
Sbjct: 2516 DGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAG 2575
Query: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA-TLLIPA 2014
+PE V L C A P ATITW K+G L TL I
Sbjct: 2576 VGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILN 2635
Query: 2015 ITTADAGFYLCVATSPAGTAQARIQVVV----------LSASDASPPPVKIESSSPSVTE 2064
+AG Y CVAT+ AG +V V L SP VKI+ ++
Sbjct: 2636 AQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNN----- 2690
Query: 2065 GQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVE 2120
TL L C A ++WY+ G L V+ G L++ + +D+G Y C
Sbjct: 2691 --TLTLECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVAS 2748
Query: 2121 NGSGPKEASITVSVLHGTHSGPSYTPV--PGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQ 2178
N +G E V++ PS+ + G+ + V + L C
Sbjct: 2749 NIAGEDELDFDVNI----QVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAA 2804
Query: 2179 AHAQVTWHKRGGSLPARHQT----HGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVT 2234
+TW+K G L + + G +L++ + D+G Y C V +G E S+
Sbjct: 2805 PPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAG--EDSLQYD 2862
Query: 2235 IEASVIPGPIPPVRIESSSS-----TVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL--PA 2287
+ V PP+ ++S TV ++ + C+ +G + +W K G L
Sbjct: 2863 VRVLV-----PPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDD 2917
Query: 2288 RHQV--RGSRLYIFQASPADAGQYVCRASN---------GMEASITVTVTGTQGANLAYP 2336
H+ G L I D G+YVC A N + + +V G + NL
Sbjct: 2918 HHKFLSNGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLT-- 2975
Query: 2337 AGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQT----HGSLL 2392
V + L C V G ++W K + + T G L
Sbjct: 2976 ---------------VVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTL 3020
Query: 2393 RLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSS----QV 2448
++ +A +D GEY C + + + +T+ V P+++ S S V
Sbjct: 3021 QIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY---------VPPSIKDHDSESLSVVNV 3071
Query: 2449 AEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCR 2504
EG ++ L C +TW+K G + V G L + + +D+G+YVCR
Sbjct: 3072 REGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCR 3131
Query: 2505 VVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHT 2564
+ +G + + + + S +G V +E+ S + + L C P T
Sbjct: 3132 AINVAGRDDKNFHLNVYVPPS---IEGPEREVIVETIS------NPVTLTCDATGIPPPT 3182
Query: 2565 ITWYKR------GGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQ 2618
I W K SL R GS+L+I + +DSG Y C SN G + ++IQ
Sbjct: 3183 IAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQ 3242
Query: 2619 GSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS------ 2672
S V P S +V+ G+ ++L C P +I W K G + S
Sbjct: 3243 VPPS--VAGAEIP-----SDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERI 3295
Query: 2673 RHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEA--SIVISVSPSAGSPSAPGSSMPIR 2730
R +GS L ++ +D+G+Y C A N + ++ + V+P+ +
Sbjct: 3296 RVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTL 3355
Query: 2731 IESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR----GSRLRLHHVSPA 2786
+++S +++ C G Q+ W K G LP R G +R+ +
Sbjct: 3356 VDTS---------INIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVS 3406
Query: 2787 DSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSR---VAEGQT 2843
D Y C V +G H APP + V +G +
Sbjct: 3407 DVAVYTC--------------VASNRAGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSS 3452
Query: 2844 LDLKCVVPGQAHAQVTWHKRGGNLPARHQV----HGPLLRLNQVSPADSGEYSCQVTGSS 2899
+ C+ G + W + G L + HG +L+L + DSG+Y+C + +
Sbjct: 3453 TSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEA 3512
Query: 2900 GTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSH----VTEGQTLDLNCVVPGQAHAQ 2955
G + ++ + +P +I S H V L+L C+ G +
Sbjct: 3513 GEVSKHFILKV-------------LEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPK 3559
Query: 2956 VTWYKRGGSLPARHQTH----GSQLRLHLVSPADSGEYVCRAASGPGPE-QEASFTVTVP 3010
+TW K G LP Q G LR+ D+G Y C A+S G + +E V VP
Sbjct: 3560 MTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVP 3619
Query: 3011 PSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELE--DNVH 3068
P+ + +P TV + + + +C D P + W + L+ V
Sbjct: 3620 PNIAGTD---------EPRDITVLRNRQVTLECK-SDAVPPPVITWLRNGERLQATPRVR 3669
Query: 3069 ISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGK 3128
I G + I + Y CVASN G L+V+ PP + P+ V + + K
Sbjct: 3670 ILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLV-ILLNK 3728
Query: 3129 AVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQ 3188
+ LEC++ G P W + + A R Y ++++ L I SA +D G Y+C+A
Sbjct: 3729 STVLECIAEGVPTPRITWRKDGAVLAGNHAR-YSILEN-GFLHIQSAHVTDTGRYLCMAT 3786
Query: 3189 NALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKL 3248
NA GT ++++++ V P + +TV TL C ATG P P+I+W K
Sbjct: 3787 NAAGTDRRRIDLQVHV------PPSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKN 3840
Query: 3249 RSPLPWQHR------LEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYAT 3302
L L +L+I + D+ Y C T+ AG + T+ L V+ PP
Sbjct: 3841 GHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIA 3900
Query: 3303 TVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL----LHFERAAPE 3358
P V + C A G P + W++ G L R L +
Sbjct: 3901 DEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLN 3960
Query: 3359 DSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATS-------------IPAGSTPTVQVT 3405
+GRY C N GSA L V PP P S A TP+ +T
Sbjct: 3961 HAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFIT 4020
Query: 3406 PQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYI 3465
Q E ++ S H +PS G L+I + GTY+
Sbjct: 4021 WQKEGINVNTSGRNHAVLPS-----------------------GGLQISRAVREDAGTYM 4057
Query: 3466 CQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKV 3525
C A P G A +L +Q P + +++ V + V + C A G P P +TW K
Sbjct: 4058 CVAQNPAGTALGKIKLNVQVPPVISPHLKEYV--IAVDKPITLSCEADGLPPPDITWHKD 4115
Query: 3526 GGHLRPGIVQ---SGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI-SMP 3581
G + I Q S G ++IA V+ DAG Y C A N AG++ + L V P+I S
Sbjct: 4116 GRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTE 4175
Query: 3582 QEVRVPAGSAAVFPCIASGYPTPDISWSK----LDGSLPPDSRLENNMLMLPSVRPQDAG 3637
V S A+ PC+A G PTP I+W K L L + L+L +V +D+G
Sbjct: 4176 GHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSG 4235
Query: 3638 TYVCTATNRQGKVKAFAHLQVPERVVPYFTQTP 3670
Y C A N G+ L V V+P FT+ P
Sbjct: 4236 FYTCVANNAAGEDTHTVSLTV--HVLPTFTELP 4266
Score = 511 bits (1317), Expect = e-144
Identities = 559/2132 (26%), Positives = 842/2132 (39%), Gaps = 259/2132 (12%)
Query: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGS 1693
G Y C A TG+ Q + ++ P V++V P V G
Sbjct: 495 GFYECIAVSSAGTGR-----------------AQTFFDVSEPPPVIQV-PNNVTVTPGER 536
Query: 1694 HSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQ---GSELHFPSVQPSDAGVYICTCRN 1750
L C + + + W R D R V R + L SV+ +DAG Y C +
Sbjct: 537 AVLTCLIISAVDYNLTWQRND-RDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSS 595
Query: 1751 LHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLH 1810
S+ + L V E P VTV ++QS G++V+ +C+A + P + WT
Sbjct: 596 EGGSSAASVFLTVQEPPK----VTV-MPKNQSFTGGSEVSIMCSA-TGYPKPKIAWTVND 649
Query: 1811 NGKLPTR--AMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVV 1868
+ + M +G L I+N DAG Y C SN D+ +TL + AP +
Sbjct: 650 MFIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRY-----IEAPKL 704
Query: 1869 SIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHG---GILRLPAVEP 1925
+ +L V G + C +G P P ++W G P+ I G+L++ +
Sbjct: 705 MVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQD 764
Query: 1926 TDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSA 1985
D Y C A + AG+ + L V G P P + G V L C G P
Sbjct: 765 LDAGDYTCVAINEAGRATGKITLDV--GSPPVFIQEPADVSMEIGSNVTLPCYVQGYPEP 822
Query: 1986 TITWRKEGGSLP----PQARSERTDIAT--LLIPAITTADAGFYLCVATSPAGTAQARIQ 2039
TI WR+ ++P P + S + + T L I + +D G Y+C A + G Q+
Sbjct: 823 TIKWRRL-DNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETT 881
Query: 2040 VVVLSASDASPPPVKIESSSPSVTEGQTLDLNC-VVAGSAHAQVTWYRRGGSL---PPHT 2095
V V + P + I S +V EGQ L L C ++AG+ + W + L P T
Sbjct: 882 VTV---TGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYIT 938
Query: 2096 QVHGSRLRLPQVSPADSGEYVCRVEN--GSGPKEASITVSVLHGTHSGPSYTPVPGSTRP 2153
L + +V D GEY C N G+ K S+ V VL G
Sbjct: 939 VRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQHGQQIL-------- 990
Query: 2154 IRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG--SLPARHQTHGSLLRLHQVTPA 2211
EG + L C G V W K+G S + + G+ L+ V+P
Sbjct: 991 --------STIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPG 1042
Query: 2212 --DSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSS----TVAEGQTLDLS 2265
+SGEYVC T+G + V +T+ V P R S +V G+ + L
Sbjct: 1043 GEESGEYVCTATNTAGYAKRKVQLTV--YVRPRVFGDQRGLSQDKPVEISVLAGEEVTLP 1100
Query: 2266 CVVAGQAHAQVTWYKRGGSL----PARHQVRGSRLYIFQASPADAGQYVCRASNGMEASI 2321
C V +TW K + P + + I + +D+G Y+C A+N I
Sbjct: 1101 CEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATN-----I 1155
Query: 2322 TVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL 2381
VT N+ P I+ P +V GQ +D+ C G +TW K G ++
Sbjct: 1156 AGNVTQAVKLNVHVP----PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTM 1211
Query: 2382 PVRHQTHGS----LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTP 2437
V + H S L + QA+P+D+G Y C + E + + ++ +V L
Sbjct: 1212 LVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDL---- 1267
Query: 2438 TVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQ-----VHGSRLRLLQ 2492
++ + Q ++ C G + W G L R G+ L +
Sbjct: 1268 EPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIAS 1327
Query: 2493 VTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552
VTP D+GEY+C V +GT E + + H V ++ + L N T +
Sbjct: 1328 VTPYDNGEYICVAVNEAGTTERKYNLKV-------HVPPVIKDKEQVTNVSVLLNQLT-N 1379
Query: 2553 LNCLVASQAPHTITWYKRGGSLPSRHQIV----GSRLRIPQVTPADSGEYVCHVSNGAGS 2608
L C V I WYK + I G L++ + TP D+G Y C N AG+
Sbjct: 1380 LFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGT 1439
Query: 2609 RETSLIVTIQGSGSSHVPSVSPPIRIESSSP---TVVEGQTLDLNCVVARQPQAIITWYK 2665
+ + + + PP I ++ P +VV + + L C V P I W+K
Sbjct: 1440 SQKYFNIDV----------LVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFK 1489
Query: 2666 RG-----GSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSP 2720
G G G L L D G Y C +N I +++ P
Sbjct: 1490 DGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYI---PP 1546
Query: 2721 SAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT----RGS 2776
S G ++ I V + L C G +TW+K G + S Q +G
Sbjct: 1547 SIKGGNVTTDIS-----VLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQ 1601
Query: 2777 RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIR---IEP 2833
L + +DS Y C V A+V T E S V+VP P I P
Sbjct: 1602 YLHIPRAQVSDSATYTCHV--------ANVAGTAEKSFHVDVYVP-----PMIEGNLATP 1648
Query: 2834 SSSRVAEGQTLDLKCVVPGQAHAQVTWHKRG----GNLPARHQVHGPLLRLNQVSPADSG 2889
+ +V +L L+C G +TW K G N R + G L + D G
Sbjct: 1649 LNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRG 1708
Query: 2890 EYSCQVTGSSGTLEA--SVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCV 2947
+Y C T +G E V V + P+ G E S V L+L+C
Sbjct: 1709 QYICVATSVAGEKEIKYEVDVLVPPAIEGG-----------DETSYFIVMVNNLLELDCH 1757
Query: 2948 VPGQAHAQVTWYKRGGSLPARH----QTHGSQLRLHLVSPADSGEYVCRAASGPGP-EQE 3002
V G + W K G + R +G +L + +++G Y C AA+ G ++E
Sbjct: 1758 VTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKE 1817
Query: 3003 ASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQE 3062
TV VPP+ SS V+ P + +C I +G S+ W +Q
Sbjct: 1818 FEVTVHVPPTIKSSGLSERVVVKYKP----------VALQC-IANGIPNPSITWLKDDQP 1866
Query: 3063 L---EDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV----S 3115
+ + N+ I +G ++ I T + G Y CVA+NA G Q + L VH PP++
Sbjct: 1867 VNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGK 1926
Query: 3116 VLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSA 3175
+L E V V V LEC +AG P W + + + T+ ++ ++ I SA
Sbjct: 1927 MLNE---TVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTF--LNRGQIIDIESA 1981
Query: 3176 KPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSA 3235
+ SDAG Y C+A N+ G + + V AP + + V + L C A
Sbjct: 1982 QISDAGIYKCVAINSAGATELFYSLQVHV------APSISGSNNMVAVVVNNPVRLECEA 2035
Query: 3236 TGSPAPTIHWSKLRSPL-PWQHRLE----GDTLIIPRVAQQDSGQYICNATSPAGHAEAT 3290
G PAP++ W K SP+ + + L+ G L + D+G+Y C A + AG +
Sbjct: 2036 RGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRD 2095
Query: 3291 IILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL---PGRATARN 3347
I L V PP ++ SV + V+L C + PP T W + G L PG + + N
Sbjct: 2096 IDLRVYVPPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISEN 2155
Query: 3348 -ELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTP 3406
+L E A +D+GRY C TN G E + + PP GS Q+T
Sbjct: 2156 RSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNI-------GGSDELTQLT- 2207
Query: 3407 QLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV------LRIQNLDQSC 3460
+E G + C L W K+G + + + L+I ++S
Sbjct: 2208 VIE----GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSD 2263
Query: 3461 QGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVV-GHAVEFECLALGDPKPQ 3519
Y C A G A+ L + P++ + + +V G ++ EC G P P
Sbjct: 2264 AALYSCVASNVAGTAKKEYNLQVYIRPTITNSGSHPTEIIVTRGKSISLECEVQGIPPPT 2323
Query: 3520 VTWSKVGGHLRPG----IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL 3575
VTW K G L I+ G ++++ ++ ++D G+Y C A N AG T L V A
Sbjct: 2324 VTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAP 2383
Query: 3576 PQI----SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDG---SLPPDSRL--ENNML 3626
P I P+ + V ++ C ASG P P I+W K DG SL R+ ML
Sbjct: 2384 PSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFK-DGWPVSLSNSVRILSGGRML 2442
Query: 3627 MLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
L +DAG Y C N G+ + L V
Sbjct: 2443 RLMQTTMEDAGQYTCVVRNAAGEERKIFGLSV 2474
Score = 501 bits (1289), Expect = e-141
Identities = 516/2089 (24%), Positives = 822/2089 (39%), Gaps = 237/2089 (11%)
Query: 1672 TNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSEL 1731
T Q P V V P G S+ C +G P W+ D V S + L
Sbjct: 607 TVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSDGTL 666
Query: 1732 HFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTF 1791
+ P DAG+Y C N ++ + L EAP + +S+ + D+T
Sbjct: 667 FIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEAPKLMVV------QSELLVALGDITV 720
Query: 1792 ICTAKSKSPAYTLVWTRLHNGKLPTRAMDF------NGILTIRNVQLSDAGTYVCTGSNM 1845
+ S P + W + G L R F G+L I+ Q DAG Y C N
Sbjct: 721 MECKTSGIPPPQVKWFK---GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCVAINE 777
Query: 1846 FAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGG 1905
G TL V S PV P ++++ G C G P PT++W
Sbjct: 778 AGRATGKITLDVG-----SPPVFIQEPADVSMEIGSNVTLPCYVQGYPEPTIKWRRLDNM 832
Query: 1906 QLPAK-------AQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRV 1958
+ ++ +Q+ G L + + +D+ Y+C A + G+ + + V G P +
Sbjct: 833 PIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLI 892
Query: 1959 QVSPERTQVHAGRTVRLYCR-AAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITT 2017
+SP V G+ + L C AG P W K L +L I +
Sbjct: 893 GISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDGSLHIERVQL 952
Query: 2018 ADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGS 2077
D G Y CVA++ AGT VVV P ++ S EG + L C +G+
Sbjct: 953 QDGGEYTCVASNVAGTNNKTTSVVVHVL-----PTIQHGQQILSTIEGIPVTLPCKASGN 1007
Query: 2078 AHAQVTWYRRGGSLPPHTQVH--GSRLRLPQVSPA--DSGEYVCRVENGSGPKEASITVS 2133
V W ++G + + G+ L VSP +SGEYVC N +G + + ++
Sbjct: 1008 PKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLT 1067
Query: 2134 V-----LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKR 2188
V + G G S +P+ I V G+ + L C V +TW K
Sbjct: 1068 VYVRPRVFGDQRGLS------QDKPVEIS-----VLAGEEVTLPCEVKSLPPPIITWAKE 1116
Query: 2189 GGSLPARHQTHGSL----LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPI 2244
+ H L +++ + +DSG Y+C +G + +V + +
Sbjct: 1117 TQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQAVKLNVHVP------ 1170
Query: 2245 PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL--PARHQVRG--SRLYIFQ 2300
P ++ V GQ +D+ C G +TW K G ++ H V L I Q
Sbjct: 1171 PKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQ 1230
Query: 2301 ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIR-IEP----SSSQVAEG 2355
A+P+DAG Y C A+N + GT + + +EP + +
Sbjct: 1231 ATPSDAGIYTCVATN---------IAGTDETEITLHVQEPPTVEDLEPPYNTTFQERVAN 1281
Query: 2356 QTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ-----THGSLLRLYQASPADSGEYVCRVL 2410
Q ++ C G + W G L R G+LL + +P D+GEY+C +
Sbjct: 1282 QRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAV 1341
Query: 2411 GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAE--GQTLDLNCLVAGQAHAQV 2468
+ E + + V P ++ + + V+ Q +L C V G +
Sbjct: 1342 NEAGTTERKYNLKVH---------VPPVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPII 1392
Query: 2469 TWHKRGGSLPARHQV----HGSRLRLLQVTPADSGEYVCRVVGSSGTQEA--SVLVTIQQ 2522
W+K + + +G L+L + TP D+G Y C+ + +GT + ++ V +
Sbjct: 1393 MWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPP 1452
Query: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL----PSRH 2578
+ G++ +P + S+ + L C V I W+K G L P+
Sbjct: 1453 TIIGTN-----FP-----NEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLFLGDPNVE 1502
Query: 2579 QI-VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESS 2637
+ G L + D G Y C VSN AG + + +TI S +V+ I
Sbjct: 1503 LLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTTDI----- 1557
Query: 2638 SPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQT----HGSHLRLHQMSVADSGE 2693
+V+ + L C P ITWYK G + S Q G +L + + V+DS
Sbjct: 1558 --SVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSAT 1615
Query: 2694 YVCRANNNIDALEASIVISVSPSAGSPSAPGS-SMPIRIESSSSHVAEGETLDLNCVVPG 2752
Y C N E S + V P G+ + P+ + V +L L C G
Sbjct: 1616 YTCHVANVAGTAEKSFHVDVYV---PPMIEGNLATPL-----NKQVVIAHSLTLECKAAG 1667
Query: 2753 QAHAQVTWHKRGGSLPSHHQTR----GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLV 2808
+TW K G + ++ R G +L + D G+Y+C +G E V
Sbjct: 1668 NPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAGEKEIKYEV 1727
Query: 2809 TIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP 2868
+ + PA G E S V L+L C V G + W K G +
Sbjct: 1728 DV-------LVPPAIEGGD----ETSYFIVMVNNLLELDCHVTGSPPPTIMWLKDGQLID 1776
Query: 2869 ARH----QVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLA 2924
R ++G L + Q +++G Y C ++G + VT+ P I + GL+
Sbjct: 1777 ERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVH--VPPTIKSSGLS 1834
Query: 2925 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK-------RGGSLPARHQTHGSQLR 2977
+ + V + + + L C+ G + +TW K G+L + Q+ G L+
Sbjct: 1835 ERV--------VVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNL--KIQSSGRVLQ 1884
Query: 2978 LHLVSPADSGEYVCRAASGPG-PEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQG 3036
+ D+G Y C A + G +Q V PPS + ++ + + + P
Sbjct: 1885 IAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLVSNP------- 1937
Query: 3037 QDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTRPSNHGTYRCVAS 3094
+C P+ + W N+ L + ++ G II I + S+ G Y+CVA
Sbjct: 1938 --VQLECKAAGNPVPV-ITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAI 1994
Query: 3095 NAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPA 3154
N+ G + +L VH P++S V V V V LEC + G P S W + +P
Sbjct: 1995 NSAGATELFYSLQVHVAPSISG-SNNMVAVVVNNPVRLECEARGIPAPSLTWLK-DGSPV 2052
Query: 3155 KLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV 3214
++ +L ++SA+ SD G Y C+A NA G Q+ +++ V P +
Sbjct: 2053 SSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRVYV------PPNI 2106
Query: 3215 QAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL---PWQHRLEGDTLIIPRVAQ- 3270
EE ++V L C + P PT+ W K PL P E +++ AQ
Sbjct: 2107 MGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQV 2166
Query: 3271 QDSGQYICNATSPAGHAEATIILHVESPPYATTVPE--HASVQAGETVQLQCLAHGTPPL 3328
QD+G+Y C AT+ AG E +++ PP E +V G + L C + G PP
Sbjct: 2167 QDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPP 2226
Query: 3329 TFQWSRVGSSLPGRATARNELLHFER------AAPEDSGRYRCRVTNKVGSAEAFAQLLV 3382
W + GS + + R +L R A D+ Y C +N G+A+ L V
Sbjct: 2227 NLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQV 2286
Query: 3383 QGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPP 3442
P T +GS PT + + G S+ C V + W K+G L
Sbjct: 2287 YIRP-----TITNSGSHPTEIIVTR------GKSISLECEVQGIPPPTVTWMKDGHPLIK 2335
Query: 3443 GHSV----QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQ 3498
V + +L+++N+ S G Y+C A G L + A PS++ N R+
Sbjct: 2336 AKGVEILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPEN 2395
Query: 3499 -TVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG----IVQSGGVVRIAHVELADAGQY 3553
+VV ++V C A G P P +TW K G + I+ G ++R+ + DAGQY
Sbjct: 2396 ISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAGQY 2455
Query: 3554 RCTATNAAGTTQSHVLLLVQALPQI---SMPQEVRVPAGSAAVFPCIASGYPTPDISWSK 3610
C NAAG + L V P I + ++V+V + C +G P P+I+W K
Sbjct: 2456 TCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHK 2515
Query: 3611 LDGSLPPDSRLE----NNMLMLPSVRPQDAGTYVCTATNRQG-KVKAFA 3654
L D L + +V+ G Y C A++ G K ++F+
Sbjct: 2516 DGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFS 2564
Score = 490 bits (1261), Expect = e-137
Identities = 526/2084 (25%), Positives = 807/2084 (38%), Gaps = 230/2084 (11%)
Query: 1696 LRCQVSGSPPHYFYWSREDGRPV--PSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQ 1753
L CQ PP W + DG P+ G S L Q D G Y C N+
Sbjct: 2123 LLCQSDAIPPPTLTWLK-DGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAG 2181
Query: 1754 SNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGK 1813
+ + P+ + +E +V G ++ +C + S P L+W + +
Sbjct: 2182 KTEKNYNVNIWVPPNIGGS---DELTQLTVIEGNLISLLCES-SGIPPPNLIWKKKGSPV 2237
Query: 1814 LP-----TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVV 1868
L R + L I + SDA Y C SN+ + L V T++
Sbjct: 2238 LTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNS-- 2295
Query: 1869 SIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQI---HGGILRLPAVEP 1925
HP ++ V G+ C G P PT+ W + AK G IL+L +
Sbjct: 2296 GSHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHV 2355
Query: 1926 TDQAQYLCRAHSSAGQQVARAVLHVHGG----GGPRVQVSPERTQVHAGRTVRLYCRAAG 1981
+D +Y+C A + AG + L VH G R SPE V +V L C A+G
Sbjct: 2356 SDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHR---SPENISVVEKNSVSLTCEASG 2412
Query: 1982 VPSATITWRKEGGSLPPQARSERTDIAT----LLIPAITTADAGFYLCVATSPAGTAQAR 2037
+P +ITW K+G P + S I + L + T DAG Y CV + AG +
Sbjct: 2413 IPLPSITWFKDGW---PVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKI 2469
Query: 2038 IQVVVLSASDASPPPVKIESS--SPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPP-- 2093
+ VL PP + E++ V E Q++ L C V G+ ++TW++ G L
Sbjct: 2470 FGLSVLV-----PPHIVGENTLEDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDE 2524
Query: 2094 -HTQVHGSR-LRLPQVSPADSGEYVCRVENGSGPKEASITVSV-LHGTHSGPSYTPVPGS 2150
H + G R L++ V +G Y C + +G K S +++V + T +G P
Sbjct: 2525 AHHIISGGRFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPED 2584
Query: 2151 TRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH----GSLLRLH 2206
I P+S L C A +TW K G L + G L++
Sbjct: 2585 VTVILNSPTS----------LVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQIL 2634
Query: 2207 QVTPADSGEYVCHVVGTSGPL--EASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDL 2264
++G Y C +G + V V I + G + + + TL L
Sbjct: 2635 NAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTL 2694
Query: 2265 SCVVAGQAHAQVTWYKRGGSLPARHQVR----GSRLYIFQASPADAGQYVCRASNGM--- 2317
C A ++WYK G L + V G L I +A +D G+Y C ASN
Sbjct: 2695 ECEAYAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGED 2754
Query: 2318 EASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR 2377
E V + + G+ + V + L C +TW+K
Sbjct: 2755 ELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKD 2814
Query: 2378 GGSLPVRHQT----HGSLLRLYQASPADSGEYVCRVLGS----SVPLEASVLVTIEPAGS 2429
G L + G +L++ +A D+G Y C + S+ + VLV G+
Sbjct: 2815 GHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGA 2874
Query: 2430 VPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL--PARHQV--HG 2485
L TV + S+ + CL +G + +W K G L H+ +G
Sbjct: 2875 NSDLPEEVTVLVNKSAL---------IECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNG 2925
Query: 2486 SRLRLLQVTPADSGEYVCRVVGSSGTQEA--SVLVTIQQRLSGSHSQGVAYPVRIESSSA 2543
L++L D G YVC ++G+ + ++ V + + G S+ + V
Sbjct: 2926 RILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSENLTVVVN------ 2979
Query: 2544 SLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV----GSRLRIPQVTPADSGEYV 2599
+ + L C V+ P ++W K + + G L+I + +D GEY
Sbjct: 2980 -----NFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYT 3034
Query: 2600 CHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQA 2659
C N AG + +T+ PS+ S V EG ++ L C P
Sbjct: 3035 CIAINQAGESKKKFSLTVYVP-----PSIKDHDSESLSVVNVREGTSVSLECESNAVPPP 3089
Query: 2660 IITWYKRGGSLPSRHQTH------GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISV 2713
+ITWYK G + TH G L + + V+D+G+YVCRA N + + ++V
Sbjct: 3090 VITWYKNGRMITE--STHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNV 3147
Query: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTW---HKR---GGSL 2767
PS G + +E+ S+ V L C G + W HKR SL
Sbjct: 3148 YVP---PSIEGPEREVIVETISNPVT------LTCDATGIPPPTIAWLKNHKRIENSDSL 3198
Query: 2768 PSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAP 2827
+ GS+L++ +DSG Y C G + ++I+ P+ GA
Sbjct: 3199 EVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVP-------PSVAGAE 3251
Query: 2828 PIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA------RHQVHGPLLRLN 2881
PS V G+ ++L C G + W K G + + R +G L +
Sbjct: 3252 I----PSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIY 3307
Query: 2882 QVSPADSGEYSCQVTGSSGTLEA--SVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEG 2939
+D+G+Y+C T +G + ++ V + P+ G EA
Sbjct: 3308 GALTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGNKD----------EAEKLMTLVD 3357
Query: 2940 QTLDLNCVVPGQAHAQVTWYKRGGSLPA----RHQTHGSQLRLHLVSPADSGEYVCRAAS 2995
++++ C G Q+ W K G LP R G +R+ +D Y C A++
Sbjct: 3358 TSINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASN 3417
Query: 2996 GPGPEQEA-SFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISL 3054
G + + + V PP+ +S + TV +G S C I DG S+
Sbjct: 3418 RAGVDNKHYNLQVFAPPNMDNS---------MGTEEITVLKGSSTSMAC-ITDGTPAPSM 3467
Query: 3055 EWKTRNQELEDNVH--ISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPP 3112
W Q L + H +S +G ++ ++ + G Y C+ASN G L V PP
Sbjct: 3468 AWLRDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPP 3527
Query: 3113 TVSVLPEGP-VWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ-RTYGLMDSHAVL 3170
++ E + V V + L C+++G P W + + +Q +T G VL
Sbjct: 3528 HINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLG---GGEVL 3584
Query: 3171 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTAT 3230
+IS+A+ D G Y CLA + G K+ V V G E ++TV T
Sbjct: 3585 RISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTD----EPRDITVLRNRQVT 3640
Query: 3231 LRCSATGSPAPTIHWSKLRSPLPWQHRLE----GDTLIIPRVAQQDSGQYICNATSPAGH 3286
L C + P P I W + L R+ G L I D+ Y C A++ AG
Sbjct: 3641 LECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGK 3700
Query: 3287 AEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR---- 3342
IL V PP P+ + ++ L+C+A G P W + G+ L G
Sbjct: 3701 TTREFILTVNVPPNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHARY 3760
Query: 3343 ATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTV 3402
+ N LH + A D+GRY C TN G+ L V PP P P T V
Sbjct: 3761 SILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPG---PTNMTVIV 3817
Query: 3403 QVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHS------VQDGVLRIQNL 3456
V L ++ G +P + W K G L + + G L I +
Sbjct: 3818 NVQTTLACEATG--------IPKP---SINWRKNGHLLNVDQNQNSYRLLSSGSLVIISP 3866
Query: 3457 DQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHA-VEFECLALGD 3515
TY C G + + L +Q PS+ +V HA C A G
Sbjct: 3867 SVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADE---PTDFLVTKHAPAVITCTASGV 3923
Query: 3516 PKPQVTWSKVGGHLRPG----IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLL 3571
P P + W+K G L P + S G + I +L AG+Y C A NAAG+ HV L
Sbjct: 3924 PFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLH 3983
Query: 3572 VQALPQIS-MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR----LENNML 3626
V P I P E+ V + + PC A+G P+P I+W K ++ R L + L
Sbjct: 3984 VHEPPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGGL 4043
Query: 3627 MLPSVRPQDAGTYVCTATNRQGKV--KAFAHLQVPERVVPYFTQ 3668
+ +DAGTY+C A N G K ++QVP + P+ +
Sbjct: 4044 QISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKE 4087
Score = 481 bits (1237), Expect = e-135
Identities = 519/2074 (25%), Positives = 808/2074 (38%), Gaps = 247/2074 (11%)
Query: 1696 LRCQVSGSPPHYFYWSREDGRPVPS--GTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQ 1753
L C V+GSPP W + DG+ + G + G +L Q S+ G+Y C N
Sbjct: 1754 LDCHVTGSPPPTIMWLK-DGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAG 1812
Query: 1754 SNTSRAELLVTEAP-------SKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVW 1806
+ E+ V P S+ + V + Q + G I K P T
Sbjct: 1813 DHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTA-- 1870
Query: 1807 TRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAP 1866
G L ++ +L I L DAG Y C +N Q LHV +L
Sbjct: 1871 ----QGNLKIQSS--GRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDA 1924
Query: 1867 VVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP---GGQLPAKAQIHGGILRLPAV 1923
++ L P QL C A G+P P + W G G I+ + +
Sbjct: 1925 GKMLNETVLVSNPVQL---ECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESA 1981
Query: 1924 EPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVP 1983
+ +D Y C A +SAG L VH P + S V VRL C A G+P
Sbjct: 1982 QISDAGIYKCVAINSAGATELFYSLQVHVA--PSISGSNNMVAVVVNNPVRLECEARGIP 2039
Query: 1984 SATITWRKEGGSLPPQARSERTDIAT----LLIPAITTADAGFYLCVATSPAGTAQARIQ 2039
+ ++TW K+G P + S + + L + + +D G Y CVA + AG Q I
Sbjct: 2040 APSLTWLKDGS--PVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDID 2097
Query: 2040 VVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL--PPHTQV 2097
+ V PP + E + SV Q ++L C +TW + G L P +
Sbjct: 2098 LRVYV-----PPNIMGEEQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSI 2152
Query: 2098 HGSR--LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIR 2155
+R L++ D+G Y C N +G E + V++ + G S
Sbjct: 2153 SENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNIGGSD----------- 2201
Query: 2156 IEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL------PARHQTHGSLLRLHQVT 2209
E + V EG + L C G + W K+G + R + G L++
Sbjct: 2202 -ELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILSGGRQLQISIAE 2260
Query: 2210 PADSGEYVC---HVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC 2266
+D+ Y C +V GT+ E ++ V I ++ P I V G+++ L C
Sbjct: 2261 KSDAALYSCVASNVAGTAKK-EYNLQVYIRPTITNSGSHPTEI-----IVTRGKSISLEC 2314
Query: 2267 VVAGQAHAQVTWYKRGGSLPARHQVR----GSRLYIFQASPADAGQYVCRASNGMEASIT 2322
V G VTW K G L V G L + +D G+YVC +
Sbjct: 2315 EVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVSDTGRYVC---------VA 2365
Query: 2323 VTVTGTQGANLAYPAGSTQPIRI-----EPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR 2377
V V G + Y P I P + V E ++ L C G +TW K
Sbjct: 2366 VNVAGM--TDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKD 2423
Query: 2378 GG----SLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVP----LEASVLVTIEPAGS 2429
G S VR + G +LRL Q + D+G+Y C V ++ SVLV G
Sbjct: 2424 GWPVSLSNSVRILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGE 2483
Query: 2430 VPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLP---ARHQVHGS 2486
V +V E Q++ L C V G ++TWHK G L A H + G
Sbjct: 2484 NTLEDV-----------KVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGG 2532
Query: 2487 R-LRLLQVTPADSGEYVCRVVGSSG--TQEASVLVTIQQRLSGSHSQGVAYPVRIESSSA 2543
R L++ V +G Y C +G ++ S+ V + ++G S G V + +S
Sbjct: 2533 RFLQITNVQVPHTGRYTCLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSP 2592
Query: 2544 SLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV----GSRLRIPQVTPADSGEYV 2599
+ L C S P TITW+K G L S I G L+I ++G Y
Sbjct: 2593 T-------SLVCEAYSYPPATITWFKDGTPLESNRNIRILPGGRTLQILNAQEDNAGRYS 2645
Query: 2600 CHVSNGAGSR----ETSLIVT-IQGSGSSHVPSVSPP-IRIESSSPTVVEGQTLDLNCVV 2653
C +N AG E + + I G P +SP ++I+ ++ TL L C
Sbjct: 2646 CVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNN-------TLTLECEA 2698
Query: 2654 ARQPQAIITWYKRGGSLPSRHQTH----GSHLRLHQMSVADSGEYVCRANN--NIDALEA 2707
P A ++WYK G L S + G L++ + ++D+G Y C A+N D L+
Sbjct: 2699 YAIPSASLSWYKDGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDF 2758
Query: 2708 SIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSL 2767
+ I V PS G+ + + V + L C +TW+K G L
Sbjct: 2759 DVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPL 2818
Query: 2768 PSHHQTR----GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAP 2823
S + G L++ D+G Y C V + +G ++
Sbjct: 2819 TSSDKVLILPGGRVLQIPRAKVEDAGRYTC--------------VAVNEAGEDSLQYDVR 2864
Query: 2824 GGAPPIRIEPSSSRVAEGQTLD------LKCVVPGQAHAQVTWHKRGGNL--PARHQV-- 2873
PPI I+ ++S + E T+ ++C+ G + +W K G L H+
Sbjct: 2865 VLVPPI-IKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLS 2923
Query: 2874 HGPLLRLNQVSPADSGEYSCQVTGSSGTLEA--SVLVTIEPSSPGPIPAPGLAQPIYIEA 2931
+G +L++ D G Y C ++G+ + ++ V + PS GP ++
Sbjct: 2924 NGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGP------------KS 2971
Query: 2932 SSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQT----HGSQLRLHLVSPADSG 2987
+ V + L C V G ++W K + T G L++ +D G
Sbjct: 2972 ENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGG 3031
Query: 2988 EYVCRAASGPGPEQEA-SFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIH 3046
EY C A + G ++ S TV VPPS V++ V++G S +C +
Sbjct: 3032 EYTCIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVN-------VREGTSVSLECESN 3084
Query: 3047 DGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVV 3104
P+ + W + + ++ H+ +G ++ I S+ G Y C A N G
Sbjct: 3085 AVPPPV-ITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNF 3143
Query: 3105 NLSVHGPPTVSVLPEGPVWVK-VGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGL 3163
+L+V+ PP++ PE V V+ + VTL C + G P + W + + +
Sbjct: 3144 HLNVYVPPSIEG-PEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRI 3202
Query: 3164 MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV 3223
+ + LQI+ ++ SD+G Y C+A N G AQK + + GA ++++V
Sbjct: 3203 LSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGA----EIPSDVSV 3258
Query: 3224 EAGHTATLRCSATGSPAPTIHWSKLRSPLP------WQHRLEGDTLIIPRVAQQDSGQYI 3277
G L C+A G P P I W K P+ + G TL I D+G+Y
Sbjct: 3259 LLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYT 3318
Query: 3278 CNATSPAGHAEATIILHVESPPYATTVPEHAS---VQAGETVQLQCLAHGTPPLTFQWSR 3334
C AT+PAG + L+V P + A ++ ++C A GTPP W +
Sbjct: 3319 CVATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLK 3378
Query: 3335 VGSSLP----GRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLP 3390
G LP R A +++ RA D Y C +N+ G L V PP
Sbjct: 3379 NGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNM-- 3436
Query: 3391 ATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP-PGH---SV 3446
S T ++T G+S C + W ++G L H S
Sbjct: 3437 -----DNSMGTEEITVLK-----GSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVST 3486
Query: 3447 QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAV 3506
VL++ + G Y C A G+ L + P + + +V+V + +
Sbjct: 3487 HGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVLEPPHINGSEEHEEISVIVNNPL 3546
Query: 3507 EFECLALGDPKPQVTWSKVGGHL----RPGIVQSGGVVRIAHVELADAGQYRCTATNAAG 3562
E C+A G P P++TW K G L + + G V+RI+ ++ D G+Y C A++ AG
Sbjct: 3547 ELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAG 3606
Query: 3563 TTQSHVLLLVQALPQIS---MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDS 3619
L+ V P I+ P+++ V C + P P I+W + L
Sbjct: 3607 DDDKEYLVRVHVPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATP 3666
Query: 3620 RLE----NNMLMLPSVRPQDAGTYVCTATNRQGK 3649
R+ L + + D Y C A+N GK
Sbjct: 3667 RVRILSGGRYLQINNADLGDTANYTCVASNIAGK 3700
Score = 469 bits (1208), Expect = e-131
Identities = 516/2108 (24%), Positives = 805/2108 (38%), Gaps = 267/2108 (12%)
Query: 1676 PLVVEVH--PARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSEL 1731
P ++ H P V + S SL C+ SG P W + DG PV R G L
Sbjct: 2384 PSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFK-DGWPVSLSNSVRILSGGRML 2442
Query: 1732 HFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTF 1791
DAG Y C RN L V P T+E+ + V+ VT
Sbjct: 2443 RLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVK---VKEKQSVTL 2499
Query: 1792 ICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILT------IRNVQLSDAGTYVCTGSNM 1845
C +P + W H P + + + I++ I NVQ+ G Y C S+
Sbjct: 2500 TCEVTG-NPVPEITW---HKDGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYTCLASSP 2555
Query: 1846 FAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGG 1905
+ +L+V S T++ +P +TV C A P T+ W G
Sbjct: 2556 AGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPATITWFKD-GT 2614
Query: 1906 QLPAKAQIH----GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVH---------- 1951
L + I G L++ + + +Y C A + AG+ + + V+
Sbjct: 2615 PLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEAGEMIKHYEVKVYIPPIINKGDL 2674
Query: 1952 -GGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA-- 2008
G G +SP+ ++ T+ L C A +PSA+++W K+G P + +IA
Sbjct: 2675 WGPG-----LSPKEVKIKVNNTLTLECEAYAIPSASLSWYKDG---QPLKSDDHVNIAAN 2726
Query: 2009 --TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKI----------- 2055
TL I +D G Y CVA++ AG + V + P K+
Sbjct: 2727 GHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNI----QVPPSFQKLWEIGNMLDTGR 2782
Query: 2056 ESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----HGSRLRLPQVSPAD 2111
+ V + L C + +TWY+ G L +V G L++P+ D
Sbjct: 2783 NGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVED 2842
Query: 2112 SGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIE-PSSSHVAEGQTLD 2170
+G Y C N +G V VL VP + + P V ++
Sbjct: 2843 AGRYTCVAVNEAGEDSLQYDVRVL-----------VPPIIKGANSDLPEEVTVLVNKSAL 2891
Query: 2171 LNCVVPGQAHAQVTWHKRGGSLPA----RHQTHGSLLRLHQVTPADSGEYVCHVVGTSGP 2226
+ C+ G + +W K G L + ++G +L++ D G YVC T+G
Sbjct: 2892 IECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENTAG- 2950
Query: 2227 LEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLP 2286
A + V P I P +S + TV + L+C V+G ++W K +
Sbjct: 2951 -SAKKYFNLNVHVPPSVIGP---KSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIK 3006
Query: 2287 ARHQVR----GSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQP 2342
G L I +A +D G+Y C I + G +
Sbjct: 3007 LNTNTLIVPGGRTLQIIRAKVSDGGEYTC---------IAINQAGESKKKFSLTVYVPPS 3057
Query: 2343 IRIEPSSS----QVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTH------GSLL 2392
I+ S S V EG ++ L C +TW+K G + TH G +L
Sbjct: 3058 IKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRM--ITESTHVEILADGQML 3115
Query: 2393 RLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQ 2452
+ +A +D+G+YVCR + + + + + + S+ G V +E+ S+ V
Sbjct: 3116 HIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIE--GPEREVIVETISNPVT--- 3170
Query: 2453 TLDLNCLVAGQAHAQVTW---HKR---GGSLPARHQVHGSRLRLLQVTPADSGEYVCRVV 2506
L C G + W HKR SL R GS+L++ + +DSG Y C
Sbjct: 3171 ---LTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNYTCIAS 3227
Query: 2507 GSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTIT 2566
G + ++IQ S + G P S S+ G ++L C I
Sbjct: 3228 NMEGKAQKYYFLSIQVPPSVA---GAEIP-----SDVSVLLGENVELVCNANGIPTPLIQ 3279
Query: 2567 WYKRGGSLPS------RHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGS 2620
W K G + S R GS L I +D+G+Y C +N AG + + +
Sbjct: 3280 WLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIFNLNVY-- 3337
Query: 2621 GSSHVPSVSPPIR---IESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS----R 2673
V+P IR E+ + ++++ C P I W K G LP R
Sbjct: 3338 -------VTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINWLKNGLPLPLSSHIR 3390
Query: 2674 HQTHGSHLRLHQMSVADSGEYVCRANNN--IDALEASIVISVSPSAGSPSAPGSSMPIRI 2731
G +R+ + V+D Y C A+N +D ++ + P+ M +
Sbjct: 3391 LLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPN----------MDNSM 3440
Query: 2732 ESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGG--SLPSHH--QTRGSRLRLHHVSPAD 2787
+ V +G + + C+ G + W + G L +H T G L+L D
Sbjct: 3441 GTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKAETED 3500
Query: 2788 SGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLK 2847
SG+Y C +G + ++ + + P G+ E V L+L
Sbjct: 3501 SGKYTCIASNEAGEVSKHFILKV-------LEPPHINGSE----EHEEISVIVNNPLELT 3549
Query: 2848 CVVPGQAHAQVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGTLE 2903
C+ G ++TW K G LP QV G +LR++ D+G Y+C + +G +
Sbjct: 3550 CIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDDD 3609
Query: 2904 ASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGG 2963
LV + P G +P I V + + L C +TW + G
Sbjct: 3610 KEYLVRVHV----PPNIAGTDEPRDIT-----VLRNRQVTLECKSDAVPPPVITWLRNGE 3660
Query: 2964 SLPA----RHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE-QEASFTVTVPPSEGSSYR 3018
L A R + G L+++ D+ Y C A++ G +E TV VPP+
Sbjct: 3661 RLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNVPPN------ 3714
Query: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN---VHISPNGSI 3075
I P S + + +C I +G + W+ L N I NG
Sbjct: 3715 -----IKGGPQSLVILLNKSTVLEC-IAEGVPTPRITWRKDGAVLAGNHARYSILENG-F 3767
Query: 3076 ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECV 3135
+ I ++ G Y C+A+NA G + ++L VH PP+++ P + V V TL C
Sbjct: 3768 LHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTN-MTVIVNVQTTLACE 3826
Query: 3136 SAGEPRSSARWTRISST-PAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTA 3194
+ G P+ S W + Q +Y L+ S +++ IS + D TY C N G
Sbjct: 3827 ATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVIISPSV-DDTATYECTVTNGAGDD 3885
Query: 3195 QKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL-- 3252
++ V++ V P + E + V A + C+A+G P P+IHW+K L
Sbjct: 3886 KRTVDLTVQV------PPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLP 3939
Query: 3253 --PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASV 3310
L + I +G+Y C A + AG A + LHV PP P V
Sbjct: 3940 RGDGYRILSSGAIEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHV 3999
Query: 3311 QAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL------LHFERAAPEDSGRYR 3364
+ L C A GTP W + G ++ + RN L RA ED+G Y
Sbjct: 4000 ILNNPILLPCEATGTPSPFITWQKEGINV--NTSGRNHAVLPSGGLQISRAVREDAGTYM 4057
Query: 3365 CRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGAS--VEFHCA 3422
C N G+A +L VQ PP ++P L+ I + C
Sbjct: 4058 CVAQNPAGTALGKIKLNVQVPP----------------VISPHLKEYVIAVDKPITLSCE 4101
Query: 3423 VPSDRGTQLRWFKEGGQLPPG---HSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASA 3479
+ W K+G + + G L+I + G Y C A G + S
Sbjct: 4102 ADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTST 4161
Query: 3480 QLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK----VGGHLRPGIVQ 3535
+L + P I TV C+A G P P + W K + L +
Sbjct: 4162 KLTVHVPPR--IRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAE 4219
Query: 3536 SGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVF 3594
G + + +V L D+G Y C A NAAG V L V LP + +P +V + G
Sbjct: 4220 PYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRL 4279
Query: 3595 PCIASGYPTPDISWSKLDGSLPP--DSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKA 3652
C A+G P P ++W+ + +P DS ++ L++ V +D+GTYVCTA N G VKA
Sbjct: 4280 SCKATGIPLPKLTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKA 4339
Query: 3653 FAHLQVPE 3660
+ V E
Sbjct: 4340 IGFVYVKE 4347
Score = 468 bits (1204), Expect = e-131
Identities = 513/2072 (24%), Positives = 804/2072 (38%), Gaps = 263/2072 (12%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAGVYICTCRNLH 1752
SL C+ PP W + DG P+ S R G L + Q +AG Y C N
Sbjct: 2594 SLVCEAYSYPPATITWFK-DGTPLESNRNIRILPGGRTLQILNAQEDNAGRYSCVATNEA 2652
Query: 1753 QSNTSRAELLVTEAP---SKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRL 1809
E+ V P + + ++ +T C A + P+ +L W +
Sbjct: 2653 GEMIKHYEVKVYIPPIINKGDLWGPGLSPKEVKIKVNNTLTLECEAYA-IPSASLSWYK- 2710
Query: 1810 HNGKLPTRAMDFNGI------LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTL 1863
+G+ P ++ D I L I+ Q+SD G Y C SN+ D+ +++Q +
Sbjct: 2711 -DGQ-PLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSF 2768
Query: 1864 SAPVVSIHPPQLTVQPGQLAE--------FRCSATGSPTPTLEW--TGGPGGQLPAKAQI 1913
+ I T + G+ + C +P PTL W G P +
Sbjct: 2769 QK-LWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGHPLTSSDKVLIL 2827
Query: 1914 HGG-ILRLPAVEPTDQAQYLCRAHSSAGQQ-----VARAVLHVHGGGGPRVQVSPERTQV 1967
GG +L++P + D +Y C A + AG+ V V + G + PE V
Sbjct: 2828 PGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLVPPIIKGANSDL---PEEVTV 2884
Query: 1968 HAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLL-IPAITTADAGFYLCV 2026
++ + C ++G P+ +W+K+G L + +L I D G Y+CV
Sbjct: 2885 LVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCV 2944
Query: 2027 ATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYR 2086
A + AG+A+ + V P + +S + +V + L C V+G ++W +
Sbjct: 2945 AENTAGSAKKYFNLNV----HVPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLK 3000
Query: 2087 RGGSLPPHTQV----HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGP 2142
+ +T G L++ + +D GEY C N +G + +++V
Sbjct: 3001 NEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTVY------- 3053
Query: 2143 SYTPVPGSTRPIRIEPSSS-HVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH-- 2199
VP S + E S +V EG ++ L C +TW+K G + TH
Sbjct: 3054 ----VPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMIT--ESTHVE 3107
Query: 2200 ----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASV-IPGPIPPVRIESSSS 2254
G +L + + +D+G+YVC + +G + + + + I GP V +E+ S+
Sbjct: 3108 ILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPSIEGPEREVIVETISN 3167
Query: 2255 TVAEGQTLDLSCVVAGQAHAQVTWYKR------GGSLPARHQVRGSRLYIFQASPADAGQ 2308
V L+C G + W K SL R GS+L I ++ +D+G
Sbjct: 3168 PVT------LTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGN 3221
Query: 2309 YVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIE----PSSSQVAEGQTLDLNCVV 2364
Y C ASN ME A Y P + PS V G+ ++L C
Sbjct: 3222 YTCIASN-MEGK----------AQKYYFLSIQVPPSVAGAEIPSDVSVLLGENVELVCNA 3270
Query: 2365 PGQSHAQVTWHKRGGSLP------VRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEA 2418
G + W K G + +R +GS L +Y A +D+G+Y C
Sbjct: 3271 NGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTC----------- 3319
Query: 2419 SVLVTIEPAGSVPALG-----VTPTVR---IESSSSQVAEGQTLDLNCLVAGQAHAQVTW 2470
V PAG + VTPT+R E+ ++++ C G Q+ W
Sbjct: 3320 ---VATNPAGEEDRIFNLNVYVTPTIRGNKDEAEKLMTLVDTSINIECRATGTPPPQINW 3376
Query: 2471 HKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSG 2526
K G LP + G +R+++ +D Y C +G + + +
Sbjct: 3377 LKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAPPNM 3436
Query: 2527 SHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP-SRHQIVGSRL 2585
+S G ++ SS S+A C+ ++ W + G L H V +
Sbjct: 3437 DNSMGTEEITVLKGSSTSMA--------CITDGTPAPSMAWLRDGQPLGLDAHLTVSTHG 3488
Query: 2586 RIPQVTPA---DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVV 2642
+ Q+ A DSG+Y C SN AG I+ + P ++ E S V+
Sbjct: 3489 MVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKVL-----EPPHINGSEEHEEIS--VI 3541
Query: 2643 EGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH----GSHLRLHQMSVADSGEYVCRA 2698
L+L C+ + P +TW K G LP Q G LR+ V D+G Y C A
Sbjct: 3542 VNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLA 3601
Query: 2699 NNNI--DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHA 2756
++ D E + + V P+ P +R + L C
Sbjct: 3602 SSPAGDDDKEYLVRVHVPPNIAGTDEPRDITVLR----------NRQVTLECKSDAVPPP 3651
Query: 2757 QVTWHKRGGSLPSHHQTR----GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEA 2812
+TW + G L + + R G L++++ D+ Y C +G ++T
Sbjct: 3652 VITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILT--- 3708
Query: 2813 SGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQ 2872
V+VP P I+ P S + ++ L+C+ G ++TW K G L H
Sbjct: 3709 -----VNVP-----PNIKGGPQSLVILLNKSTVLECIAEGVPTPRITWRKDGAVLAGNHA 3758
Query: 2873 VHGPL----LRLNQVSPADSGEYSCQVTGSSGT--LEASVLVTIEPS-SPGPIPAPGLAQ 2925
+ L L + D+G Y C T ++GT + V + PS +PGP
Sbjct: 3759 RYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGP-------- 3810
Query: 2926 PIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQL----RLHLV 2981
+ + + QT L C G + W K G L + +L L ++
Sbjct: 3811 -----TNMTVIVNVQTT-LACEATGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLVII 3864
Query: 2982 SPA--DSGEYVCRAASGPGPEQEA-SFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQD 3038
SP+ D+ Y C +G G ++ TV VPPS I+ +P V +
Sbjct: 3865 SPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPS-----------IADEPTDFLVTKHAP 3913
Query: 3039 ASFKCLIHDGAAPISLEWKTRNQEL---EDNVHISPNGSIITIVGTRPSNHGTYRCVASN 3095
A C P S+ W L D I +G+I I+ T+ ++ G Y CVA N
Sbjct: 3914 AVITCTASGVPFP-SIHWTKNGIRLLPRGDGYRILSSGAI-EILATQLNHAGRYTCVARN 3971
Query: 3096 AYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAK 3155
A G A V L VH PP + P + V + + L C + G P W +
Sbjct: 3972 AAGSAHRHVTLHVHEPPVIQPQPS-ELHVILNNPILLPCEATGTPSPFITWQK-EGINVN 4029
Query: 3156 LEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQ 3215
R + ++ S LQIS A DAGTY+C+AQN GTA ++++ V P +
Sbjct: 4030 TSGRNHAVLPSGG-LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQV------PPVIS 4082
Query: 3216 AEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR---LEGDTLIIPRVAQQD 3272
E + TL C A G P P I W K + R L +L I V D
Sbjct: 4083 PHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGD 4142
Query: 3273 SGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQW 3332
+G Y C A + AG + + L V PP + H +V L C+A G P W
Sbjct: 4143 AGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVADGIPTPAINW 4202
Query: 3333 SRVG---SSLPGRATAR--NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG 3387
+ ++L G+ TA EL+ E EDSG Y C N G L V
Sbjct: 4203 KKDNVLLANLLGKYTAEPYGELI-LENVVLEDSGFYTCVANNAAGEDTHTVSLTVH---- 4257
Query: 3388 SLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ 3447
PT P + + G + C +L W +P
Sbjct: 4258 ----------VLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAHFDSV 4307
Query: 3448 DG--VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHA 3505
+G L I+ + + GTY+C A G +A + ++ P + ++ + G+A
Sbjct: 4308 NGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNA 4367
Query: 3506 VEFECLALGDPKPQVTWSKVGGHLRPG--IVQSG-GVVRIAHVELADAGQYRCTATNAAG 3562
+ C GDP P + W++ G + I Q G G + I DAG Y C ATN AG
Sbjct: 4368 I-LNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG 4426
Query: 3563 TTQSHVLLLVQALPQISM-PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR- 3620
+ + L +Q+ P I++ P E + AG + C A+G P P I+WS+ S+ D R
Sbjct: 4427 VVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRV 4486
Query: 3621 --LENNMLMLPSVRPQDAGTYVCTATNRQGKV 3650
L NN L + + +D + C A N G V
Sbjct: 4487 NVLSNNSLYIADAQKEDTSEFECVARNLMGSV 4518
Score = 463 bits (1192), Expect = e-129
Identities = 527/2159 (24%), Positives = 835/2159 (38%), Gaps = 287/2159 (13%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAGVYI 1745
V + S +L C+V+G+P W + DG+P+ G L +VQ G Y
Sbjct: 2491 VKEKQSVTLTCEVTGNPVPEITWHK-DGQPLQEDEAHHIISGGRFLQITNVQVPHTGRYT 2549
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
C + + L V +P+ + +V + + +C A S PA T+
Sbjct: 2550 CLASSPAGHKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTSLVCEAYSYPPA-TIT 2608
Query: 1806 W----TRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS- 1860
W T L + + R + L I N Q +AG Y C +N + G H +
Sbjct: 2609 WFKDGTPLESNR-NIRILPGGRTLQILNAQEDNAGRYSCVATN----EAGEMIKHYEVKV 2663
Query: 1861 --------GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQ 1912
G L P +S P ++ ++ C A P+ +L W GQ P K+
Sbjct: 2664 YIPPIINKGDLWGPGLS--PKEVKIKVNNTLTLECEAYAIPSASLSWY--KDGQ-PLKSD 2718
Query: 1913 IH------GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG----------GGGP 1956
H G L++ + +D +Y C A + AG+ +++ G
Sbjct: 2719 DHVNIAANGHTLQIKEAQISDTGRYTCVASNIAGEDELDFDVNIQVPPSFQKLWEIGNML 2778
Query: 1957 RVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA----TLLI 2012
+ E V + LYC P T+TW K+G P S++ I L I
Sbjct: 2779 DTGRNGEAKDVIINNPISLYCETNAAPPPTLTWYKDGH---PLTSSDKVLILPGGRVLQI 2835
Query: 2013 PAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLN- 2071
P DAG Y CVA + AG + V VL PP+ I+ ++ + E T+ +N
Sbjct: 2836 PRAKVEDAGRYTCVAVNEAGEDSLQYDVRVLV------PPI-IKGANSDLPEEVTVLVNK 2888
Query: 2072 -----CVVAGSAHAQVTWYRRGGSL--PPHTQV--HGSRLRLPQVSPADSGEYVCRVENG 2122
C+ +GS + +W + G L H + +G L++ D G YVC EN
Sbjct: 2889 SALIECLSSGSPAPRNSWQKDGQPLLEDDHHKFLSNGRILQILNTQITDIGRYVCVAENT 2948
Query: 2123 SGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSH--VAEGQTLDLNCVVPGQAH 2180
+G + ++V H PS I P S + V + L C V G
Sbjct: 2949 AGSAKKYFNLNV----HVPPSV-----------IGPKSENLTVVVNNFISLTCEVSGFPP 2993
Query: 2181 AQVTWHKRGGSLPARHQT----HGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIE 2236
++W K + T G L++ + +D GEY C + +G + +T+
Sbjct: 2994 PDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQAGESKKKFSLTV- 3052
Query: 2237 ASVIPGPIPPVRIESSSST-VAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR--- 2292
+P I ES S V EG ++ L C +TWYK G + V
Sbjct: 3053 --YVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILA 3110
Query: 2293 -GSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIE-PSSS 2350
G L+I +A +D GQYVCRA N V G N + P IE P
Sbjct: 3111 DGQMLHIKKAEVSDTGQYVCRAIN---------VAGRDDKN--FHLNVYVPPSIEGPERE 3159
Query: 2351 QVAE--GQTLDLNCVVPGQSHAQVTW---HKR---GGSLPVRHQTHGSLLRLYQASPADS 2402
+ E + L C G + W HKR SL VR + GS L++ ++ +DS
Sbjct: 3160 VIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDS 3219
Query: 2403 GEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG 2462
G Y C + ++I+ SV + V V G+ ++L C G
Sbjct: 3220 GNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDV-------SVLLGENVELVCNANG 3272
Query: 2463 QAHAQVTWHKRGGSLPA------RHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEA-- 2514
+ W K G + + R +GS L + +D+G+Y C +G ++
Sbjct: 3273 IPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEEDRIF 3332
Query: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL 2574
++ V + + G+ + +++S +++ C P I W K G L
Sbjct: 3333 NLNVYVTPTIRGNKDEAEKLMTLVDTS---------INIECRATGTPPPQINWLKNGLPL 3383
Query: 2575 PSRHQI----VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
P I G +RI + +D Y C SN AG + + P++
Sbjct: 3384 PLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNRAGVDNKHYNLQVFAP-----PNMDN 3438
Query: 2631 PIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP-SRH---QTHGSHLRLHQM 2686
+ E TV++G + + C+ P + W + G L H THG L+L +
Sbjct: 3439 SMGTEEI--TVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHGMVLQLLKA 3496
Query: 2687 SVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDL 2746
DSG+Y C A+N + ++ V P GS E V L+L
Sbjct: 3497 ETEDSGKYTCIASNEAGEVSKHFILKVLEP---PHINGSE-----EHEEISVIVNNPLEL 3548
Query: 2747 NCVVPGQAHAQVTWHKRGGSLPSHHQTR----GSRLRLHHVSPADSGEYVCRVMGSSGPL 2802
C+ G ++TW K G LP Q + G LR+ D+G Y C +G
Sbjct: 3549 TCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGEVLRISTAQVEDTGRYTCLASSPAGDD 3608
Query: 2803 EASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHK 2862
+ LV VHVP EP V + + L+C +TW +
Sbjct: 3609 DKEYLVR--------VHVPPNIAGTD---EPRDITVLRNRQVTLECKSDAVPPPVITWLR 3657
Query: 2863 RGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPI 2918
G L A +V G L++N D+ Y+C + +G ++T+ P
Sbjct: 3658 NGERLQATPRVRILSGGRYLQINNADLGDTANYTCVASNIAGKTTREFILTVNV----PP 3713
Query: 2919 PAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHG----S 2974
G Q + I + S V E C+ G ++TW K G L H +
Sbjct: 3714 NIKGGPQSLVILLNKSTVLE-------CIAEGVPTPRITWRKDGAVLAGNHARYSILENG 3766
Query: 2975 QLRLHLVSPADSGEYVCRAASGPGPEQEA-SFTVTVPPSEGSSYRLRSPVISIDPPSSTV 3033
L + D+G Y+C A + G ++ V VPPS I+ P + TV
Sbjct: 3767 FLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPS-----------IAPGPTNMTV 3815
Query: 3034 QQGQDASFKCLIHDGAAPISLEWKTRNQEL-----EDNVHISPNGSIITIVGTRPSNHGT 3088
+ C G S+ W+ L +++ + +GS++ I+ + T
Sbjct: 3816 IVNVQTTLACEA-TGIPKPSINWRKNGHLLNVDQNQNSYRLLSSGSLV-IISPSVDDTAT 3873
Query: 3089 YRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR 3148
Y C +N G + V+L+V PP+++ P + K AV + C ++G P S WT+
Sbjct: 3874 YECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAV-ITCTASGVPFPSIHWTK 3932
Query: 3149 ISSTPAKLEQRT--YGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGA 3206
+L R Y ++ S A+ +I + + + AG Y C+A+NA G+A + V + V
Sbjct: 3933 ---NGIRLLPRGDGYRILSSGAI-EILATQLNHAGRYTCVARNAAGSAHRHVTLHVHE-- 3986
Query: 3207 MAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR----LEGDT 3262
P +Q + +EL V + L C ATG+P+P I W K + R L
Sbjct: 3987 ----PPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSGG 4042
Query: 3263 LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLA 3322
L I R ++D+G Y+C A +PAG A I L+V+ PP + + + + + L C A
Sbjct: 4043 LQISRAVREDAGTYMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYVIAVDKPITLSCEA 4102
Query: 3323 HGTPPLTFQWSRVGSSLPGRATAR---NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQ 3379
G PP W + G ++ R + L P D+G Y C N GS+ +
Sbjct: 4103 DGLPPPDITWHKDGRAIVESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTK 4162
Query: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEG-- 3437
L V PP ++ T T + + C + W K+
Sbjct: 4163 LTVHVPP--------------RIRSTEGHYTVNENSQAILPCVADGIPTPAINWKKDNVL 4208
Query: 3438 -GQLPPGHSVQD-GVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRT 3495
L ++ + G L ++N+ G Y C A+ G+ + L + LP+ +
Sbjct: 4209 LANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAAGEDTHTVSLTVHVLPT-FTELPG 4267
Query: 3496 SVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG---IVQSGGVVRIAHVELADAGQ 3552
V ++ G + C A G P P++TW+ ++ P V + I V D+G
Sbjct: 4268 DV-SLNKGEQLRLSCKATGIPLPKLTWT-FNNNIIPAHFDSVNGHSELVIERVSKEDSGT 4325
Query: 3553 YRCTATNAAGTTQSHVLLLVQALPQIS--MPQEVRVPAGSAAVFPCIASGYPTPDISWSK 3610
Y CTA N+ G ++ + V+ P P P G A+ C G PTP I W++
Sbjct: 4326 YVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNWIEPLGGNAILNCEVKGDPTPTIQWNR 4385
Query: 3611 LDGSLPPDSRLE---NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFT 3667
+ R+ N L + +DAG Y C ATN G V ER +
Sbjct: 4386 KGVDIEISHRIRQLGNGSLAIYGTVNEDAGDYTCVATNEAG---------VVERSMSLTL 4436
Query: 3668 QTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISF 3726
Q+P P+ T++ +A G ++ N Q PT +RQ IS+
Sbjct: 4437 QSP----PIITLEPVETVI---------NAGGKIILNCQATGEPQPTITWSRQGHSISW 4482
Score = 461 bits (1187), Expect = e-129
Identities = 492/1994 (24%), Positives = 745/1994 (37%), Gaps = 277/1994 (13%)
Query: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAE 1884
L I V LSD G Y C + GT + PV+ + P +TV PG+ A
Sbjct: 484 LDIAKVTLSDEGFYECIAVS----SAGTGRAQTFFDVSEPPPVIQV-PNNVTVTPGERAV 538
Query: 1885 FRCSATGSPTPTLEWTGGPGGQL---PAKAQIHGGI-LRLPAVEPTDQAQYLCRAHSSAG 1940
C + L W PA+ + + L L +V+ D +Y C S G
Sbjct: 539 LTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGG 598
Query: 1941 QQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQA 2000
A L V P+V V P+ G V + C A G P I W +
Sbjct: 599 SSAASVFLTVQEP--PKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSH 656
Query: 2001 RSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSP 2060
R T TL I DAG Y C+A++ AGT + + + A P + + S
Sbjct: 657 RYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEA-----PKLMVVQSEL 711
Query: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHT----QVHGSRLRLPQVSPADSGEYV 2116
V G + C +G QV W++ L P T L++ + D+G+Y
Sbjct: 712 LVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYT 771
Query: 2117 CRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVP 2176
C N +G IT+ V GS EP+ + G + L C V
Sbjct: 772 CVAINEAGRATGKITLDV--------------GSPPVFIQEPADVSMEIGSNVTLPCYVQ 817
Query: 2177 GQAHAQVTWHK--------RGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLE 2228
G + W + R S+ + Q L + + +D G Y+C G ++
Sbjct: 818 GYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQFGKIQ 877
Query: 2229 ASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC-VVAGQAHAQVTWYKRGGSLPA 2287
+ VT+ V P + I S + V EGQ L L C ++AG + W K L
Sbjct: 878 SETTVTVTGLV----APLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSAMLLQ 933
Query: 2288 RHQV---RGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIR 2344
+ L+I + D G+Y C ASN V GT + I+
Sbjct: 934 NPYITVRSDGSLHIERVQLQDGGEYTCVASN---------VAGTNNKTTSVVVHVLPTIQ 984
Query: 2345 IEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ--THGSLLRLYQASPA-- 2400
EG + L C G V W K+G + + G+ LY SP
Sbjct: 985 HGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGSLYVVSPGGE 1044
Query: 2401 DSGEYVCRVLGSSVPLEASVLVT--IEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC 2458
+SGEYVC ++ + V +T + P G++ +E S V G+ + L C
Sbjct: 1045 ESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEIS---VLAGEEVTLPC 1101
Query: 2459 LVAGQAHAQVTWHKRGGSL----PARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEA 2514
V +TW K + P + +++ + +DSG Y+C +G
Sbjct: 1102 EVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNIAGNVTQ 1161
Query: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASL--ANGHTLDLNCLVASQAPHTITWYKRGG 2572
+V + + P +I+ L G +D+ C ITW K G
Sbjct: 1162 AVKLNVH------------VPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGS 1209
Query: 2573 SL--PSRHQIVG--SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSV 2628
++ H + L I Q TP+D+G Y C +N AG+ ET + + +Q + V +
Sbjct: 1210 TMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPT--VEDL 1267
Query: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQ-----THGSHLRL 2683
PP ++ V Q ++ C P+ I W G L R G+ L +
Sbjct: 1268 EPP--YNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVI 1325
Query: 2684 HQMSVADSGEYVCRANNNIDALEA--SIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEG 2741
++ D+GEY+C A N E ++ + V P + + + ++ V
Sbjct: 1326 ASVTPYDNGEYICVAVNEAGTTERKYNLKVHVPP----------VIKDKEQVTNVSVLLN 1375
Query: 2742 ETLDLNCVVPGQAHAQVTWHKRGGSL--PSHHQT--RGSRLRLHHVSPADSGEYVCR--- 2794
+ +L C V G + W+K + S QT G L+L +P D+G Y C+
Sbjct: 1376 QLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFRATPEDAGRYSCKAIN 1435
Query: 2795 ------------------VMGSSGPLEASVLVTIEASGSSAVH-VPAP------GGAPPI 2829
++G++ P E SV++ + + V P P G P
Sbjct: 1436 IAGTSQKYFNIDVLVPPTIIGTNFPNEVSVVLNRDVALECQVKGTPFPDIHWFKDGKPLF 1495
Query: 2830 RIEPSSSRVAEGQTLDLK-----------CVVPGQAHAQ--------------------- 2857
+P+ + GQ L LK C V A Q
Sbjct: 1496 LGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNAAGKQAKDIKLTIYIPPSIKGGNVTT 1555
Query: 2858 -----------------------VTWHKRGGNLPARHQV----HGPLLRLNQVSPADSGE 2890
+TW+K G + + Q G L + + +DS
Sbjct: 1556 DISVLINSLIKLECETRGLPMPAITWYKDGQPIMSSSQALYIDKGQYLHIPRAQVSDSAT 1615
Query: 2891 YSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPG 2950
Y+C V +GT E S V + P+ LA P+ + V +L L C G
Sbjct: 1616 YTCHVANVAGTAEKSFHVDVYVP---PMIEGNLATPL-----NKQVVIAHSLTLECKAAG 1667
Query: 2951 QAHAQVTWYKRGGSLPA----RHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFT 3006
+TW K G + A R + G +L + D G+Y+C A S G E+E +
Sbjct: 1668 NPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSAQEIDRGQYICVATSVAG-EKEIKYE 1726
Query: 3007 VTV---PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL 3063
V V P EG + V C + G+ P ++ W Q +
Sbjct: 1727 VDVLVPPAIEGGD----------ETSYFIVMVNNLLELDCHV-TGSPPPTIMWLKDGQLI 1775
Query: 3064 E--DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP 3121
+ D I NG + I + SN G YRC+A+N G + ++VH PPT+
Sbjct: 1776 DERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSE 1835
Query: 3122 VWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAG 3181
V K V L+C++ G P S W + P Q + S VLQI+ DAG
Sbjct: 1836 RVVVKYKPVALQCIANGIPNPSITWLK-DDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAG 1894
Query: 3182 TYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAP 3241
Y C+A NA G Q+ +++ V A ++ E TV + L C A G+P P
Sbjct: 1895 RYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNE----TVLVSNPVQLECKAAGNPVP 1950
Query: 3242 TIHWSK----LRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVES 3297
I W K L G + I D+G Y C A + AG E L V
Sbjct: 1951 VITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHV 2010
Query: 3298 PPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG-----RATARNELLHF 3352
P + +V V+L+C A G P + W + GS + + + +L
Sbjct: 2011 APSISGSNNMVAVVVNNPVRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGRILAL 2070
Query: 3353 ERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKS 3412
A D+GRY C N G + L V PP + G V V
Sbjct: 2071 TSAQISDTGRYTCVAVNAAGEKQRDIDLRVYVPPNIM-------GEEQNVSVL------- 2116
Query: 3413 IGASVEFHCAVPSDRGTQLRWFKEGGQL--PPGHSVQD--GVLRIQNLDQSCQGTYICQA 3468
I +VE C + L W K+G L PG S+ + VL+I++ G Y C+A
Sbjct: 2117 ISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISENRSVLKIEDAQVQDTGRYTCEA 2176
Query: 3469 HGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGH 3528
GK + + + I P++ + + TV+ G+ + C + G P P + W K G
Sbjct: 2177 TNVAGKTEKNYNVNIWVPPNIGGSDELTQLTVIEGNLISLLCESSGIPPPNLIWKKKGSP 2236
Query: 3529 L------RPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI---- 3578
+ R I+ G ++I+ E +DA Y C A+N AGT + L V P I
Sbjct: 2237 VLTDSMGRVRILSGGRQLQISIAEKSDAALYSCVASNVAGTAKKEYNLQVYIRPTITNSG 2296
Query: 3579 SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL----ENNMLMLPSVRPQ 3634
S P E+ V G + C G P P ++W K L + E ++L L ++
Sbjct: 2297 SHPTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEGHILQLKNIHVS 2356
Query: 3635 DAGTYVCTATNRQG 3648
D G YVC A N G
Sbjct: 2357 DTGRYVCVAVNVAG 2370
Score = 459 bits (1180), Expect = e-128
Identities = 492/1988 (24%), Positives = 776/1988 (39%), Gaps = 262/1988 (13%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELHFPSVQPSDAGVYICTCRNLH 1752
+L C+ P W + DG+P+ S G L Q SD G Y C N+
Sbjct: 2693 TLECEAYAIPSASLSWYK-DGQPLKSDDHVNIAANGHTLQIKEAQISDTGRYTCVASNIA 2751
Query: 1753 QSNTSRAELLVTEAPSKP-------ITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
+ ++ + PS + T ++ V ++ C + P TL
Sbjct: 2752 GEDELDFDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISLYCETNAAPPP-TLT 2810
Query: 1806 WTRL-HNGKLPTRAMDFNG--ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGT 1862
W + H + + G +L I ++ DAG Y C N D + V
Sbjct: 2811 WYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAVNEAGEDSLQYDVRV----- 2865
Query: 1863 LSAPVV----SIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH---- 1914
L P++ S P ++TV + A C ++GSP P W GQ + H
Sbjct: 2866 LVPPIIKGANSDLPEEVTVLVNKSALIECLSSGSPAPRNSWQ--KDGQPLLEDDHHKFLS 2923
Query: 1915 -GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP--ERTQVHAGR 1971
G IL++ + TD +Y+C A ++AG L+VH P + P E V
Sbjct: 2924 NGRILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHV---PPSVIGPKSENLTVVVNN 2980
Query: 1972 TVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITT--------ADAGFY 2023
+ L C +G P ++W K + + + TL++P T +D G Y
Sbjct: 2981 FISLTCEVSGFPPPDLSWLKNEQPI-------KLNTNTLIVPGGRTLQIIRAKVSDGGEY 3033
Query: 2024 LCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSP----SVTEGQTLDLNCVVAGSAH 2079
C+A + AG ++ + + V PP +K S +V EG ++ L C
Sbjct: 3034 TCIAINQAGESKKKFSLTVYV-----PPSIKDHDSESLSVVNVREGTSVSLECESNAVPP 3088
Query: 2080 AQVTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVL 2135
+TWY+ G + T V G L + + +D+G+YVCR N +G + + ++V
Sbjct: 3089 PVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNV- 3147
Query: 2136 HGTHSGPSYTP--VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTW---HKR-- 2188
Y P + G R + +E S+ V L C G + W HKR
Sbjct: 3148 --------YVPPSIEGPEREVIVETISNPVT------LTCDATGIPPPTIAWLKNHKRIE 3193
Query: 2189 -GGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
SL R + GS L++ + +DSG Y C G + ++I+ +P +
Sbjct: 3194 NSDSLEVRILSGGSKLQIARSQHSDSGNYTCIASNMEGKAQKYYFLSIQ---VPPSVAGA 3250
Query: 2248 RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPA------RHQVRGSRLYIFQA 2301
I S S + G+ ++L C G + W K G + + R GS L I+ A
Sbjct: 3251 EIPSDVSVLL-GENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGA 3309
Query: 2302 SPADAGQYVCRASN--GMEASI---TVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQ 2356
+D G+Y C A+N G E I V VT T N + E
Sbjct: 3310 LTSDTGKYTCVATNPAGEEDRIFNLNVYVTPTIRGN-----------KDEAEKLMTLVDT 3358
Query: 2357 TLDLNCVVPGQSHAQVTWHKRGGSLP----VRHQTHGSLLRLYQASPADSGEYVCRVLG- 2411
++++ C G Q+ W K G LP +R G ++R+ +A +D Y C
Sbjct: 3359 SINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTCVASNR 3418
Query: 2412 SSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWH 2471
+ V + L P ++G ++ SS+ +A C+ G + W
Sbjct: 3419 AGVDNKHYNLQVFAPPNMDNSMGTEEITVLKGSSTSMA--------CITDGTPAPSMAWL 3470
Query: 2472 KRGGSLPARHQV----HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGS 2527
+ G L + HG L+LL+ DSG+Y C +G ++ + L
Sbjct: 3471 RDGQPLGLDAHLTVSTHGMVLQLLKAETEDSGKYTCIASNEAGEVSKHFILKV---LEPP 3527
Query: 2528 HSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV----GS 2583
H G E S+ + L+L C+ + +TW K G LP Q+ G
Sbjct: 3528 HINGSE-----EHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTLGGGE 3582
Query: 2584 RLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIR--IESSSPTV 2641
LRI D+G Y C S+ AG + +V + HVP P I E TV
Sbjct: 3583 VLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRV------HVP---PNIAGTDEPRDITV 3633
Query: 2642 VEGQTLDLNCVVARQPQAIITWYKRGGSLPS----RHQTHGSHLRLHQMSVADSGEYVCR 2697
+ + + L C P +ITW + G L + R + G +L+++ + D+ Y C
Sbjct: 3634 LRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTANYTCV 3693
Query: 2698 ANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQ 2757
A+N +++V+ P+ G + I + S V E C+ G +
Sbjct: 3694 ASNIAGKTTREFILTVNVP---PNIKGGPQSLVILLNKSTVLE-------CIAEGVPTPR 3743
Query: 2758 VTWHKRGGSLPSHHQT----RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEAS 2813
+TW K G L +H L + D+G Y+C ++G +
Sbjct: 3744 ITWRKDGAVLAGNHARYSILENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRI------- 3796
Query: 2814 GSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQV 2873
VHVP P I P++ V L C G + W K G L
Sbjct: 3797 -DLQVHVP-----PSIAPGPTNMTVIVNVQTTLACEATGIPKPSINWRKNGHLLNVDQNQ 3850
Query: 2874 HGPLL----RLNQVSPA--DSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPI 2927
+ L L +SP+ D+ Y C VT +G + +V +T++ +P P +A
Sbjct: 3851 NSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQ------VP-PSIAD-- 3901
Query: 2928 YIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH----GSQLRLHLVSP 2983
E + VT+ + C G + W K G L R + + +
Sbjct: 3902 --EPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGAIEILATQL 3959
Query: 2984 ADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKC 3043
+G Y C A + G A VT+ E PVI P V C
Sbjct: 3960 NHAGRYTCVARNAAG---SAHRHVTLHVHE-------PPVIQPQPSELHVILNNPILLPC 4009
Query: 3044 LIHDGAAPISLEWKTRNQELED---NVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVA 3100
+P + W+ + N + P+G + R + GTY CVA N G A
Sbjct: 4010 EATGTPSPF-ITWQKEGINVNTSGRNHAVLPSGGLQISRAVR-EDAGTYMCVAQNPAGTA 4067
Query: 3101 QSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAK-LEQR 3159
+ L+V PP +S + V + V K +TL C + G P W + + + QR
Sbjct: 4068 LGKIKLNVQVPPVISPHLKEYV-IAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQR 4126
Query: 3160 TYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEA 3219
S LQI+ +P DAG Y C+A N G++ ++ V P++++ E
Sbjct: 4127 VL----SSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHV------PPRIRSTEG 4176
Query: 3220 ELTVEAGHTATLRCSATGSPAPTIHWSK---LRSPLPWQHRLEG-DTLIIPRVAQQDSGQ 3275
TV A L C A G P P I+W K L + L ++ E LI+ V +DSG
Sbjct: 4177 HYTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGF 4236
Query: 3276 YICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRV 3335
Y C A + AG T+ L V P T +P S+ GE ++L C A G P W+
Sbjct: 4237 YTCVANNAAGEDTHTVSLTVHVLPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFN 4296
Query: 3336 GSSLPGRATARN--ELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATS 3393
+ +P + N L ER + EDSG Y C N VG +A + V+ PP
Sbjct: 4297 NNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPP------- 4349
Query: 3394 IPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ---DGV 3450
+ G P+ + P +G + +C V D ++W ++G + H ++ +G
Sbjct: 4350 VFKGDYPSNWIEP------LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGS 4403
Query: 3451 LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVV-VGHAVEFE 3509
L I G Y C A G + S L +Q+ P + + V+TV+ G +
Sbjct: 4404 LAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLE---PVETVINAGGKIILN 4460
Query: 3510 CLALGDPKPQVTWSKVGGHL----RPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQ 3565
C A G+P+P +TWS+ G + R ++ S + IA + D ++ C A N G+
Sbjct: 4461 CQATGEPQPTITWSRQGHSISWDDRVNVL-SNNSLYIADAQKEDTSEFECVARNLMGSVL 4519
Query: 3566 SHVLLLVQ 3573
V ++VQ
Sbjct: 4520 VRVPVIVQ 4527
Score = 442 bits (1138), Expect = e-123
Identities = 452/1798 (25%), Positives = 707/1798 (39%), Gaps = 223/1798 (12%)
Query: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAI 2015
P+V + PE+T + + ++ C + T+++ + G +L + + L I +
Sbjct: 431 PKVTM-PEKTPGYYLQPGQIPCSVDSLLPFTLSFVRNGVTLGVDQYLKESASVNLDIAKV 489
Query: 2016 TTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVA 2075
T +D GFY C+A S AGT +A+ V + PPPV ++ +VT G+ L C++
Sbjct: 490 TLSDEGFYECIAVSSAGTGRAQTFFDV-----SEPPPVIQVPNNVTVTPGERAVLTCLII 544
Query: 2076 GSAHAQVTWYR--RGGSLPPHTQVH---GSRLRLPQVSPADSGEYVCRVENGSGPKEASI 2130
+ +TW R R L ++ L L V D+GEY C V + G AS+
Sbjct: 545 SAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSEGGSSAASV 604
Query: 2131 TVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG 2190
++V P T + P + G + + C G ++ W
Sbjct: 605 FLTV----QEPPKVT----------VMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVNDM 650
Query: 2191 SLPARHQ---THGSLLRLHQVTPADSGEYVCHVVGTSG-PLEASVLVTIEASVIPGPIPP 2246
+ H+ T L + P D+G Y C ++G + S L IEA P
Sbjct: 651 FIVGSHRYRMTSDGTLFIKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIEA-------PK 703
Query: 2247 VRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQ 2300
+ + S VA G + C +G QV W+K G L R L I +
Sbjct: 704 LMVVQSELLVALGDITVMECKTSGIPPPQVKWFK--GDLELRPSTFLIIDPLLGLLKIQE 761
Query: 2301 ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDL 2360
DAG Y C + + G + GS EP+ + G + L
Sbjct: 762 TQDLDAGDYTC---------VAINEAGRATGKITLDVGSPPVFIQEPADVSMEIGSNVTL 812
Query: 2361 NCVVPGQSHAQVTWHK--------RGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGS 2412
C V G + W + R S+ Q L + +D G Y+C
Sbjct: 813 PCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEAENQ 872
Query: 2413 SVPLEASVLVTIEPAGSV-PALGVTPTVRIESSSSQVAEGQTLDLNC-LVAGQAHAQVTW 2470
+++ VT+ G V P +G++P+V + V EGQ L L C L+AG + W
Sbjct: 873 FGKIQSETTVTV--TGLVAPLIGISPSV------ANVIEGQQLTLPCTLLAGNPIPERRW 924
Query: 2471 HKRGGSLPARHQV---HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGS 2527
K L + L + +V D GEY C +GT + V + +
Sbjct: 925 IKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHVLPTIQ 984
Query: 2528 HSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGG--SLPSRHQIVGSRL 2585
H Q + S G + L C + ++ W K+G S S G+
Sbjct: 985 HGQQI----------LSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADG 1034
Query: 2586 RIPQVTPA--DSGEYVCHVSNGAG--SRETSLIVTIQGS--GSSHVPSVSPPIRIESSSP 2639
+ V+P +SGEYVC +N AG R+ L V ++ G S P+ I
Sbjct: 1035 SLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEI----- 1089
Query: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH----GSHLRLHQMSVADSGEYV 2695
+V+ G+ + L C V P IITW K + H +++ + +DSG Y+
Sbjct: 1090 SVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYL 1149
Query: 2696 CRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH--VAEGETLDLNCVVPGQ 2753
C A N + ++ ++V +P +I+ H V G+ +D+ C G
Sbjct: 1150 CVATNIAGNVTQAVKLNV------------HVPPKIQRGPKHLKVQVGQRVDIPCNAQGT 1197
Query: 2754 AHAQVTWHKRGGSL---PSHHQTR-GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVT 2809
+TW K G ++ HH + L + +P+D+G Y C +G E + +
Sbjct: 1198 PLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLH 1257
Query: 2810 IEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA 2869
++ P P RVA Q ++ C G + W G L
Sbjct: 1258 VQ-------EPPTVEDLEPPYNTTFQERVA-NQRIEFPCPAKGTPKPTIKWLHNGRELTG 1309
Query: 2870 RHQ-----VHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLA 2924
R G LL + V+P D+GEY C +GT E + + P +
Sbjct: 1310 REPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVH--------VPPVI 1361
Query: 2925 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRG----GSLPARHQTHGSQLRLHL 2980
+ + ++ V Q +L C V G + WYK S + +G L+L
Sbjct: 1362 KD-KEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYKDNVQVTESSTIQTVNNGKILKLFR 1420
Query: 2981 VSPADSGEYVCRAASGPGPEQE-ASFTVTVPPS-EGSSYRLRSPVISIDPPSSTVQQGQD 3038
+P D+G Y C+A + G Q+ + V VPP+ G+++ P +V +D
Sbjct: 1421 ATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNF----------PNEVSVVLNRD 1470
Query: 3039 ASFKCLIHDGAAPISLEWKTRNQEL---EDNVHISPNGSIITIVGTRPSNHGTYRCVASN 3095
+ +C + P + W + L + NV + G ++ + R ++ G Y+C SN
Sbjct: 1471 VALECQVKGTPFP-DIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSN 1529
Query: 3096 AYGVAQSVVNLSVHGPPTV---SVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISST 3152
A G + L+++ PP++ +V + + V + + LEC + G P + W +
Sbjct: 1530 AAGKQAKDIKLTIYIPPSIKGGNVTTD--ISVLINSLIKLECETRGLPMPAITWYKDGQP 1587
Query: 3153 PAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAP 3212
Q Y +D L I A+ SD+ TY C N GTA+K V V M G
Sbjct: 1588 IMSSSQALY--IDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGN- 1644
Query: 3213 QVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE----GDTLIIPRV 3268
A V H+ TL C A G+P+P + W K P+ + G L I
Sbjct: 1645 --LATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKKLEIMSA 1702
Query: 3269 AQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE--HASVQAGETVQLQCLAHGTP 3326
+ D GQYIC ATS AG E + V PP E + V ++L C G+P
Sbjct: 1703 QEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDCHVTGSP 1762
Query: 3327 PLTFQWSRVGSSLPGR----ATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLV 3382
P T W + G + R L +A ++G YRC N G + ++ V
Sbjct: 1763 PPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKKEFEVTV 1822
Query: 3383 QGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPP 3442
PP T +G + V V + V C + W K+ P
Sbjct: 1823 HVPP-----TIKSSGLSERVVVKYK--------PVALQCIANGIPNPSITWLKDD---QP 1866
Query: 3443 GHSVQDGVLRIQNLDQSCQ---------GTYICQAHGPWGKAQASAQLVIQALPSVLINI 3493
++ Q G L+IQ+ + Q G Y C A G+ Q QL + PS+
Sbjct: 1867 VNTAQ-GNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHEPPSLEDAG 1925
Query: 3494 RTSVQTVVVGHAVEFECLALGDPKPQVTWSK----VGGHLRPGIVQSGGVVRIAHVELAD 3549
+ +TV+V + V+ EC A G+P P +TW K + G + G ++ I +++D
Sbjct: 1926 KMLNETVLVSNPVQLECKAAGNPVPVITWYKDNRLLSGSTSMTFLNRGQIIDIESAQISD 1985
Query: 3550 AGQYRCTATNAAGTTQSHVLLLVQALPQISMPQE-VRVPAGSAAVFPCIASGYPTPDISW 3608
AG Y+C A N+AG T+ L V P IS V V + C A G P P ++W
Sbjct: 1986 AGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNPVRLECEARGIPAPSLTW 2045
Query: 3609 SKLDGSLPPDSRLENNM--------LMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
K DGS P S N + L L S + D G Y C A N G+ + L+V
Sbjct: 2046 LK-DGS--PVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQRDIDLRV 2100
Score = 382 bits (982), Expect = e-105
Identities = 392/1543 (25%), Positives = 605/1543 (39%), Gaps = 194/1543 (12%)
Query: 2203 LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTL 2262
L + +VT +D G Y C V ++G A + PPV ++ TV G+
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSEP------PPVIQVPNNVTVTPGERA 537
Query: 2263 DLSCVVAGQAHAQVTWYKRGGSL----PARHQVRGS-RLYIFQASPADAGQYVCRASNGM 2317
L+C++ +TW + + PAR + + L + DAG+Y C S+
Sbjct: 538 VLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCMVSSE- 596
Query: 2318 EASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR 2377
G+ A++ + + P + G + + C G ++ W
Sbjct: 597 --------GGSSAASVFLTVQEPPKVTVMPKNQSFTGGSEVSIMCSATGYPKPKIAWTVN 648
Query: 2378 G----GSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSS-VPLEASVLVTIEPAGSVPA 2432
GS R + G+L + A+P D+G Y C S+ + S L IE
Sbjct: 649 DMFIVGSHRYRMTSDGTLF-IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE------- 700
Query: 2433 LGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL-PARHQVHGSRLRLL 2491
P + + S VA G + C +G QV W K L P+ + L LL
Sbjct: 701 ---APKLMVVQSELLVALGDITVMECKTSGIPPPQVKWFKGDLELRPSTFLIIDPLLGLL 757
Query: 2492 QVTPA---DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRI-ESSSASLAN 2547
++ D+G+Y C + +G + + + GS PV I E + S+
Sbjct: 758 KIQETQDLDAGDYTCVAINEAGRATGKITLDV-----GSP------PVFIQEPADVSMEI 806
Query: 2548 GHTLDLNCLVASQAPHTITW--------YKRGGSLPSRHQIVGSRLRIPQVTPADSGEYV 2599
G + L C V TI W + R S+ S Q+ L I + +D G Y+
Sbjct: 807 GSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYI 866
Query: 2600 CHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC-VVARQPQ 2658
C N G ++ VT+ G V+P I I S V+EGQ L L C ++A P
Sbjct: 867 CEAENQFGKIQSETTVTVTGL-------VAPLIGISPSVANVIEGQQLTLPCTLLAGNPI 919
Query: 2659 AIITWYKRGGSL---PSRHQTHGSHLRLHQMSVADSGEYVCRANN--NIDALEASIVISV 2713
W K L P L + ++ + D GEY C A+N + S+V+ V
Sbjct: 920 PERRWIKNSAMLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNKTTSVVVHV 979
Query: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGG--SLPSHH 2771
P+ I+ EG + L C G V W K+G S S
Sbjct: 980 LPT------------IQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAK 1027
Query: 2772 QTRGSRLRLHHVSPA--DSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPI 2829
+ G+ L+ VSP +SGEYVC ++G + V +T+ P+
Sbjct: 1028 FSAGADGSLYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPV 1087
Query: 2830 RIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL----LRLNQVSP 2885
I V G+ + L C V +TW K + H L +++ +
Sbjct: 1088 EIS-----VLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRT 1142
Query: 2886 ADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSH--VTEGQTLD 2943
+DSG Y C T +G + +V + + P I+ H V GQ +D
Sbjct: 1143 SDSGMYLCVATNIAGNVTQAVKLNVHV-------------PPKIQRGPKHLKVQVGQRVD 1189
Query: 2944 LNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ----LRLHLVSPADSGEYVCRAASGPGP 2999
+ C G +TW K G ++ + H S L + +P+D+G Y C A + G
Sbjct: 1190 IPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGT 1249
Query: 3000 EQ-EASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQ----GQDASFKCLIHDGAAPISL 3054
++ E + V PP+ V ++PP +T Q Q F C P ++
Sbjct: 1250 DETEITLHVQEPPT----------VEDLEPPYNTTFQERVANQRIEFPCPAKGTPKP-TI 1298
Query: 3055 EWKTRNQEL---EDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
+W +EL E + I +G+++ I P ++G Y CVA N G + NL VH P
Sbjct: 1299 KWLHNGRELTGREPGISILEDGTLLVIASVTPYDNGEYICVAVNEAGTTERKYNLKVHVP 1358
Query: 3112 PTVSVLPEGP-VWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVL 3170
P + + V V + + L C G P W + E T +++ +L
Sbjct: 1359 PVIKDKEQVTNVSVLLNQLTNLFCEVEGTPSPIIMWYK--DNVQVTESSTIQTVNNGKIL 1416
Query: 3171 QISSAKPSDAGTYVCLAQNALGTAQK--QVEVIVDTGAMAPGAPQVQAEEAELTVEAGHT 3228
++ A P DAG Y C A N GT+QK ++V+V + P E++V
Sbjct: 1417 KLFRATPEDAGRYSCKAINIAGTSQKYFNIDVLVPPTIIGTNFPN------EVSVVLNRD 1470
Query: 3229 ATLRCSATGSPAPTIHWSKLRSPL----PWQHRLE-GDTLIIPRVAQQDSGQYICNATSP 3283
L C G+P P IHW K PL P L+ G L + + D G+Y C ++
Sbjct: 1471 VALECQVKGTPFPDIHWFKDGKPLFLGDPNVELLDRGQVLHLKNARRNDKGRYQCTVSNA 1530
Query: 3284 AGHAEATIILHVESPPYAT--TVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG 3341
AG I L + PP V SV ++L+C G P W + G +
Sbjct: 1531 AGKQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECETRGLPMPAITWYKDGQPIMS 1590
Query: 3342 RATA----RNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPP---GSLPATSI 3394
+ A + + LH RA DS Y C V N G+AE + V PP G+L
Sbjct: 1591 SSQALYIDKGQYLHIPRAQVSDSATYTCHVANVAGTAEKSFHVDVYVPPMIEGNL----- 1645
Query: 3395 PAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV---- 3450
TP + I S+ C + L W K+G + +++
Sbjct: 1646 ---------ATPLNKQVVIAHSLTLECKAAGNPSPILTWLKDGVPVKANDNIRIEAGGKK 1696
Query: 3451 LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC 3510
L I + + +G YIC A G+ + ++ + P++ TS V+V + +E +C
Sbjct: 1697 LEIMSAQEIDRGQYICVATSVAGEKEIKYEVDVLVPPAIEGGDETSYFIVMVNNLLELDC 1756
Query: 3511 LALGDPKPQVTWSKVGGHL--RPG--IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQS 3566
G P P + W K G + R G I+ +G + IA ++++ G YRC A N AG +
Sbjct: 1757 HVTGSPPPTIMWLKDGQLIDERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHKK 1816
Query: 3567 HVLLLVQALPQISMP--QEVRVPAGSAAVFPCIASGYPTPDISWSKLD-------GSLPP 3617
+ V P I E V CIA+G P P I+W K D G+L
Sbjct: 1817 EFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLKDDQPVNTAQGNLKI 1876
Query: 3618 DSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE 3660
S +L + +DAG Y C ATN G+ + L V E
Sbjct: 1877 QS--SGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHVHE 1917
Score = 226 bits (577), Expect = 3e-58
Identities = 215/837 (25%), Positives = 337/837 (40%), Gaps = 90/837 (10%)
Query: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
L + +V+ +D G Y C S+GT A + P P + P ++ VT
Sbjct: 484 LDIAKVTLSDEGFYECIAVSSAGTGRAQTFFDVSE------PPPVIQVP-----NNVTVT 532
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSL----PARHQTHGS-QLRLHLVSPADSGEYVCR 2992
G+ L C++ +TW + + PAR +T + L L V D+GEY C
Sbjct: 533 PGERAVLTCLIISAVDYNLTWQRNDRDVRLAEPARIRTLANLSLELKSVKFNDAGEYHCM 592
Query: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPI 3052
+S G + F P P +++ P + + G + S C P
Sbjct: 593 VSSEGGSSAASVFLTVQEP----------PKVTVMPKNQSFTGGSEVSIMCSATGYPKP- 641
Query: 3053 SLEWKTRNQEL--EDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG 3110
+ W + + ++ +G++ I P + G Y C+ASN+ G + L
Sbjct: 642 KIAWTVNDMFIVGSHRYRMTSDGTLF-IKNAAPKDAGIYGCLASNSAGTDKQNSTLRYIE 700
Query: 3111 PPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSH-AV 3169
P + V+ + + V +G +EC ++G P +W + +L T+ ++D +
Sbjct: 701 APKLMVV-QSELLVALGDITVMECKTSGIPPPQVKWFK---GDLELRPSTFLIIDPLLGL 756
Query: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEAGHT 3228
L+I + DAG Y C+A N G A ++ + V G+P V +E A++++E G
Sbjct: 757 LKIQETQDLDAGDYTCVAINEAGRATGKITLDV-------GSPPVFIQEPADVSMEIGSN 809
Query: 3229 ATLRCSATGSPAPTIHWSKLRS-PL---PWQ----HRLEGDTLIIPRVAQQDSGQYICNA 3280
TL C G P PTI W +L + P+ P+ +L L I + D G YIC A
Sbjct: 810 VTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTGALFILNLWASDKGTYICEA 869
Query: 3281 TSPAG--HAEATIILHVESPPYATTVPEHASVQAGETVQLQC-LAHGTPPLTFQWSRVGS 3337
+ G +E T+ + P P A+V G+ + L C L G P +W + +
Sbjct: 870 ENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLPCTLLAGNPIPERRWIKNSA 929
Query: 3338 SL---PGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSI 3394
L P + LH ER +D G Y C +N G+ TS+
Sbjct: 930 MLLQNPYITVRSDGSLHIERVQLQDGGEYTCVASNVAGTNNK--------------TTSV 975
Query: 3395 PAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV----QDGV 3450
PT+Q Q+ + G V C + + W K+G + + DG
Sbjct: 976 VVHVLPTIQHGQQILSTIEGIPVTLPCKASGNPKPSVIWSKKGELISTSSAKFSAGADGS 1035
Query: 3451 LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQ------TVVVGH 3504
L + + G Y+C A G A+ QL + P V + R Q +V+ G
Sbjct: 1036 LYVVSPGGEESGEYVCTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGE 1095
Query: 3505 AVEFECLALGDPKPQVTWSKVGGHLRPGIVQS----GGVVRIAHVELADAGQYRCTATNA 3560
V C P P +TW+K + P + G ++I +D+G Y C ATN
Sbjct: 1096 EVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSGSMKITETRTSDSGMYLCVATNI 1155
Query: 3561 AGTTQSHVLLLVQALPQISM-PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDS 3619
AG V L V P+I P+ ++V G PC A G P P I+WSK ++ D
Sbjct: 1156 AGNVTQAVKLNVHVPPKIQRGPKHLKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDG 1215
Query: 3620 RLE----NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYS 3672
+ L + P DAG Y C ATN G + L V E + PY+
Sbjct: 1216 EHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYN 1272
Score = 181 bits (458), Expect = 2e-44
Identities = 178/673 (26%), Positives = 272/673 (40%), Gaps = 61/673 (9%)
Query: 1672 TNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS-E 1730
T Q P + P +V + + C SG P +W++ R +P G R S
Sbjct: 3892 TVQVPPSIADEPTDFLVTKHAPAVITCTASGVPFPSIHWTKNGIRLLPRGDGYRILSSGA 3951
Query: 1731 LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQ-SVRPGADV 1789
+ + Q + AG Y C RN S L V E P ++ Q S+ V +
Sbjct: 3952 IEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPP------VIQPQPSELHVILNNPI 4005
Query: 1790 TFICTAKSKSPAYTLVWTRLH---NGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMF 1846
C A + +P+ + W + N A+ +G L I DAGTY+C N
Sbjct: 4006 LLPCEA-TGTPSPFITWQKEGINVNTSGRNHAVLPSGGLQISRAVREDAGTYMCVAQNPA 4064
Query: 1847 AMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQ 1906
G L+VQ PV+S H + + + C A G P P + W
Sbjct: 4065 GTALGKIKLNVQV-----PPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAI 4119
Query: 1907 LPAKAQ--IHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPER 1964
+ + Q + G L++ V+P D Y C A + AG L VH PR++ +
Sbjct: 4120 VESIRQRVLSSGSLQIAFVQPGDAGHYTCMAANVAGSSSTSTKLTVH--VPPRIRSTEGH 4177
Query: 1965 TQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPP-QARSERTDIATLLIPAITTADAGFY 2023
V+ L C A G+P+ I W+K+ L + L++ + D+GFY
Sbjct: 4178 YTVNENSQAILPCVADGIPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFY 4237
Query: 2024 LCVATSPAG--TAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQ 2081
CVA + AG T + V VL P V S+ +G+ L L+C G +
Sbjct: 4238 TCVANNAAGEDTHTVSLTVHVLPTFTELPGDV-------SLNKGEQLRLSCKATGIPLPK 4290
Query: 2082 VTWYRRGGSLPPH-TQVHG-SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTH 2139
+TW +P H V+G S L + +VS DSG YVC EN G +A V V
Sbjct: 4291 LTWTFNNNIIPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYV----- 4345
Query: 2140 SGPSYTPVPGSTRPIR-IEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH-- 2196
PV P IEP G LNC V G + W+++G + H
Sbjct: 4346 ---KEPPVFKGDYPSNWIEPL------GGNAILNCEVKGDPTPTIQWNRKGVDIEISHRI 4396
Query: 2197 -QTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSST 2255
Q L ++ D+G+Y C +G +E S+ +T+++ P + +E +
Sbjct: 4397 RQLGNGSLAIYGTVNEDAGDYTCVATNEAGVVERSMSLTLQSP------PIITLEPVETV 4450
Query: 2256 VAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR---GSRLYIFQASPADAGQYVCR 2312
+ G + L+C G+ +TW ++G S+ +V + LYI A D ++ C
Sbjct: 4451 INAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECV 4510
Query: 2313 ASNGMEASITVTV 2325
A N M S+ V V
Sbjct: 4511 ARNLM-GSVLVRV 4522
Score = 145 bits (365), Expect = 1e-33
Identities = 133/485 (27%), Positives = 193/485 (39%), Gaps = 45/485 (9%)
Query: 1674 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS-ELH 1732
Q P V+ H ++ +L C+ G PP W + DGR + +QR S L
Sbjct: 4076 QVPPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHK-DGRAIVESIRQRVLSSGSLQ 4134
Query: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPIT---VTVEEQRSQSVRPGADV 1789
VQP DAG Y C N+ S+++ +L V P T TV E SQ++ P
Sbjct: 4135 IAFVQPGDAGHYTCMAANVAGSSSTSTKLTVHVPPRIRSTEGHYTVNE-NSQAILP---- 4189
Query: 1790 TFICTAKSKSPAYTLVWTR---LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMF 1846
C A P + W + L L + G L + NV L D+G Y C +N
Sbjct: 4190 ---CVADG-IPTPAINWKKDNVLLANLLGKYTAEPYGELILENVVLEDSGFYTCVANNAA 4245
Query: 1847 AMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQ 1906
D T +L V P + P +++ G+ C ATG P P L WT
Sbjct: 4246 GEDTHTVSLTVHV-----LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFN-NNI 4299
Query: 1907 LPAKAQIHGG--ILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLH-----VHGGGGPRVQ 1959
+PA G L + V D Y+C A +S G A ++ V G P
Sbjct: 4300 IPAHFDSVNGHSELVIERVSKEDSGTYVCTAENSVGFVKAIGFVYVKEPPVFKGDYPSNW 4359
Query: 1960 VSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTAD 2019
+ P G L C G P+ TI W ++G + R + +L I D
Sbjct: 4360 IEP------LGGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIRQLGNGSLAIYGTVNED 4413
Query: 2020 AGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAH 2079
AG Y CVAT+ AG + + + + SPP + +E + G + LNC G
Sbjct: 4414 AGDYTCVATNEAGVVERSMSLTL-----QSPPIITLEPVETVINAGGKIILNCQATGEPQ 4468
Query: 2080 AQVTWYRRGGSLPPHTQVH---GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV-L 2135
+TW R+G S+ +V+ + L + D+ E+ C N G + V V +
Sbjct: 4469 PTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIVQV 4528
Query: 2136 HGTHS 2140
HG S
Sbjct: 4529 HGGFS 4533
Score = 54.7 bits (130), Expect = 2e-06
Identities = 31/83 (37%), Positives = 38/83 (45%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP + P RE I + VT TC A G+P P I W N I + + V G
Sbjct: 3149 VPPSIEGPEREVIVETISNPVTLTCDATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSK 3208
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L I + SD G YTC A N G
Sbjct: 3209 LQIARSQHSDSGNYTCIASNMEG 3231
Score = 53.1 bits (126), Expect = 6e-06
Identities = 40/122 (32%), Positives = 56/122 (45%), Gaps = 5/122 (4%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P V++P + + + +T +C A G+P P I W + I R V S G+L
Sbjct: 4078 PPVISPHLKEYVIAVDKPITLSCEADGLPPPDITWHKDGRAIVESIRQRVLSS---GSLQ 4134
Query: 466 IRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYL-EHSAACLPCFCF 524
I V+ D G YTC A N G + VP R +GH+ + E+S A LPC
Sbjct: 4135 IAFVQPGDAGHYTCMAANVAGS-SSTSTKLTVHVPPRIRSTEGHYTVNENSQAILPCVAD 4193
Query: 525 GI 526
GI
Sbjct: 4194 GI 4195
Score = 51.2 bits (121), Expect = 2e-05
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 4/76 (5%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
+ ++G+ + +C A G+P P + W N IP+H S G L+I V + D G
Sbjct: 4269 VSLNKGEQLRLSCKATGIPLPKLTWTFNNNIIPAH----FDSVNGHSELVIERVSKEDSG 4324
Query: 476 AYTCEAMNARGMVFGI 491
Y C A N+ G V I
Sbjct: 4325 TYVCTAENSVGFVKAI 4340
Score = 49.3 bits (116), Expect = 8e-05
Identities = 30/83 (36%), Positives = 41/83 (49%), Gaps = 2/83 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP V+ P E++ ++ TC G P P ++W N I + T+ GGR
Sbjct: 2962 VPPSVIGPKSENLTVVVNNFISLTCEVSGFPPPDLSWLKNEQPIKLNTN-TLIVPGGRTL 3020
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
IIR K SD G YTC A+N G
Sbjct: 3021 QIIR-AKVSDGGEYTCIAINQAG 3042
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/82 (35%), Positives = 39/82 (47%), Gaps = 4/82 (4%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP+V P+ + G V+ C A G P P I W +N I R +TS+ GTL
Sbjct: 611 PPKVTVMPKNQ-SFTGGSEVSIMCSATGYPKPKIAWTVNDMFIVGSHRYRMTSD---GTL 666
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
I++ D G Y C A N+ G
Sbjct: 667 FIKNAAPKDAGIYGCLASNSAG 688
Score = 46.6 bits (109), Expect = 5e-04
Identities = 36/124 (29%), Positives = 52/124 (41%), Gaps = 5/124 (4%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRG 462
+PP + P+ + TV C+A GVPTP I WR + + +H R ++ G
Sbjct: 3711 VPPNIKGGPQSLVILLNKSTV-LECIAEGVPTPRITWRKDGAVLAGNHARYSILE---NG 3766
Query: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCF 522
L I+ +D G Y C A NA G D + + P P P + + L C
Sbjct: 3767 FLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTVIVNVQTTLACE 3826
Query: 523 CFGI 526
GI
Sbjct: 3827 ATGI 3830
Score = 46.2 bits (108), Expect = 7e-04
Identities = 30/84 (35%), Positives = 39/84 (46%), Gaps = 3/84 (3%)
Query: 404 MPPQVV-TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
+PP + T I R + VT C + VP P+I W N + + PRV + S GGR
Sbjct: 3618 VPPNIAGTDEPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQATPRVRILS-GGR- 3675
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
L I + D YTC A N G
Sbjct: 3676 YLQINNADLGDTANYTCVASNIAG 3699
Score = 46.2 bits (108), Expect = 7e-04
Identities = 35/127 (27%), Positives = 49/127 (38%), Gaps = 9/127 (7%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR-- 461
+PP + P QT T C A G+P P INWR N GH+ + V R
Sbjct: 3802 VPPSIAPGPTNMTVIVNVQT-TLACEATGIPKPSINWRKN-GHLLN---VDQNQNSYRLL 3856
Query: 462 --GTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACL 519
G+L+I D Y C N G D +++ P P +H+ A +
Sbjct: 3857 SSGSLVIISPSVDDTATYECTVTNGAGDDKRTVDLTVQVPPSIADEPTDFLVTKHAPAVI 3916
Query: 520 PCFCFGI 526
C G+
Sbjct: 3917 TCTASGV 3923
Score = 45.4 bits (106), Expect = 0.001
Identities = 38/121 (31%), Positives = 51/121 (42%), Gaps = 5/121 (4%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWR-LNWGHIPSHP-RVTVTSEGGRG 462
PP + P + + G VT C G P P I WR L+ I S P V+ S+ G
Sbjct: 792 PPVFIQEPAD-VSMEIGSNVTLPCYVQGYPEPTIKWRRLDNMPIFSRPFSVSSISQLRTG 850
Query: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLE--LVPQRGPCPDGHFYLEHSAACLP 520
L I ++ SD+G Y CEA N G + + + P G P +E LP
Sbjct: 851 ALFILNLWASDKGTYICEAENQFGKIQSETTVTVTGLVAPLIGISPSVANVIEGQQLTLP 910
Query: 521 C 521
C
Sbjct: 911 C 911
Score = 44.7 bits (104), Expect = 0.002
Identities = 26/86 (30%), Positives = 39/86 (45%), Gaps = 5/86 (5%)
Query: 404 MPPQVVTPPRES---IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG 460
+PP + ES + G +V+ C + VP P+I W N I V + ++G
Sbjct: 3054 VPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMITESTHVEILADG- 3112
Query: 461 RGTLIIRDVKESDQGAYTCEAMNARG 486
L I+ + SD G Y C A+N G
Sbjct: 3113 -QMLHIKKAEVSDTGQYVCRAINVAG 3137
Score = 44.7 bits (104), Expect = 0.002
Identities = 28/84 (33%), Positives = 35/84 (41%), Gaps = 1/84 (1%)
Query: 404 MPPQVVTPPRES-IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
+PP V S + G+ V C A G+PTP+I W + I S +
Sbjct: 3243 VPPSVAGAEIPSDVSVLLGENVELVCNANGIPTPLIQWLKDGKPIASGETERIRVSANGS 3302
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
TL I SD G YTC A N G
Sbjct: 3303 TLNIYGALTSDTGKYTCVATNPAG 3326
Score = 44.3 bits (103), Expect = 0.003
Identities = 24/92 (26%), Positives = 38/92 (41%)
Query: 1672 TNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSEL 1731
T Q+P ++ + P +++ GG L CQ +G P WSR+ + L
Sbjct: 4435 TLQSPPIITLEPVETVINAGGKIILNCQATGEPQPTITWSRQGHSISWDDRVNVLSNNSL 4494
Query: 1732 HFPSVQPSDAGVYICTCRNLHQSNTSRAELLV 1763
+ Q D + C RNL S R ++V
Sbjct: 4495 YIADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526
Score = 43.5 bits (101), Expect = 0.005
Identities = 30/92 (32%), Positives = 44/92 (47%), Gaps = 7/92 (7%)
Query: 405 PPQVVTPPR--ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
PP ++ R E+I +V+ TC A G+P P I W + + V + S GGR
Sbjct: 2383 PPSIIGNHRSPENISVVEKNSVSLTCEASGIPLPSITWFKDGWPVSLSNSVRILS-GGRM 2441
Query: 463 TLIIRDVKESDQGAYTCEAMNARG---MVFGI 491
+++ E D G YTC NA G +FG+
Sbjct: 2442 LRLMQTTME-DAGQYTCVVRNAAGEERKIFGL 2472
Score = 42.7 bits (99), Expect = 0.008
Identities = 29/114 (25%), Positives = 49/114 (42%), Gaps = 5/114 (4%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
I +RG++++ C G+P P + W + + V + EG L ++++ SD G
Sbjct: 2302 IIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGVEILDEG--HILQLKNIHVSDTG 2359
Query: 476 AYTCEAMNARGMVFGIPDGVLELVPQ---RGPCPDGHFYLEHSAACLPCFCFGI 526
Y C A+N GM D + P P+ +E ++ L C GI
Sbjct: 2360 RYVCVAVNVAGMTDKKYDLSVHAPPSIIGNHRSPENISVVEKNSVSLTCEASGI 2413
Score = 42.4 bits (98), Expect = 0.010
Identities = 27/83 (32%), Positives = 37/83 (44%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP++ P+ ++ GQ V C A G P P+I W + V++ G T
Sbjct: 1169 VPPKIQRGPKH-LKVQVGQRVDIPCNAQGTPLPVITWSKGGSTMLVDGEHHVSNPDG--T 1225
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L I SD G YTC A N G
Sbjct: 1226 LSIDQATPSDAGIYTCVATNIAG 1248
Score = 42.4 bits (98), Expect = 0.010
Identities = 30/115 (26%), Positives = 53/115 (46%), Gaps = 5/115 (4%)
Query: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAI 431
++ CV+TN H + + P ++ P + P+E ++ T+T C A
Sbjct: 2643 RYSCVATNEAGEMIKHYEVKVYIPPIINKGDLWGPGL--SPKE-VKIKVNNTLTLECEAY 2699
Query: 432 GVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+P+ ++W + + S V + + G TL I++ + SD G YTC A N G
Sbjct: 2700 AIPSASLSWYKDGQPLKSDDHVNIAANGH--TLQIKEAQISDTGRYTCVASNIAG 2752
Score = 42.4 bits (98), Expect = 0.010
Identities = 31/116 (26%), Positives = 43/116 (37%), Gaps = 14/116 (12%)
Query: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIG 432
+ CV+TN E+ +RS P ++T + G + C A G
Sbjct: 4417 YTCVATN-----------EAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATG 4465
Query: 433 VPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMV 488
P P I W I RV V S +L I D ++ D + C A N G V
Sbjct: 4466 EPQPTITWSRQGHSISWDDRVNVLS---NNSLYIADAQKEDTSEFECVARNLMGSV 4518
Score = 42.0 bits (97), Expect = 0.013
Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP ++ +++ Q V C + +P P + W + + P ++++ R
Sbjct: 2102 VPPNIMGE-EQNVSVLISQAVELLCQSDAIPPPTLTWLKDGHPLLKKPGLSISEN--RSV 2158
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L I D + D G YTCEA N G
Sbjct: 2159 LKIEDAQVQDTGRYTCEATNVAG 2181
Score = 41.6 bits (96), Expect = 0.018
Identities = 28/83 (33%), Positives = 42/83 (50%), Gaps = 3/83 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP++ + Q + CVA G+PTP INW+ + + ++ T+E G
Sbjct: 4167 VPPRIRSTEGHYTVNENSQAI-LPCVADGIPTPAINWKKD-NVLLANLLGKYTAE-PYGE 4223
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
LI+ +V D G YTC A NA G
Sbjct: 4224 LILENVVLEDSGFYTCVANNAAG 4246
Score = 40.8 bits (94), Expect = 0.030
Identities = 28/87 (32%), Positives = 38/87 (43%), Gaps = 7/87 (8%)
Query: 405 PPQV--VTPPRESIQASR--GQTVTFTCVAIGVPTPIINWRLNWGHIPS-HPRVTVTSEG 459
PP V + PP + R Q + F C A G P P I W N + P +++ +G
Sbjct: 1261 PPTVEDLEPPYNTTFQERVANQRIEFPCPAKGTPKPTIKWLHNGRELTGREPGISILEDG 1320
Query: 460 GRGTLIIRDVKESDQGAYTCEAMNARG 486
L+I V D G Y C A+N G
Sbjct: 1321 --TLLVIASVTPYDNGEYICVAVNEAG 1345
Score = 40.8 bits (94), Expect = 0.030
Identities = 25/85 (29%), Positives = 34/85 (40%), Gaps = 2/85 (2%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P V+ P + + C A G P+P I W+ ++ + R G G I
Sbjct: 3987 PPVIQPQPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSG-GLQI 4045
Query: 466 IRDVKESDQGAYTCEAMNARGMVFG 490
R V+E D G Y C A N G G
Sbjct: 4046 SRAVRE-DAGTYMCVAQNPAGTALG 4069
Score = 40.4 bits (93), Expect = 0.039
Identities = 31/92 (33%), Positives = 39/92 (42%), Gaps = 6/92 (6%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHI-PSHPRVTVTSEGGRGTLIIRDVKESDQ 474
I G+ VT C +P PII W I P PR T G ++ I + + SD
Sbjct: 1089 ISVLAGEEVTLPCEVKSLPPPIITWAKETQLISPFSPRHTFLPSG---SMKITETRTSDS 1145
Query: 475 GAYTCEAMNARGMVFGIPDGVLELVP--QRGP 504
G Y C A N G V + + P QRGP
Sbjct: 1146 GMYLCVATNIAGNVTQAVKLNVHVPPKIQRGP 1177
Score = 40.0 bits (92), Expect = 0.051
Identities = 25/67 (37%), Positives = 33/67 (49%), Gaps = 4/67 (5%)
Query: 421 GQTVTFTCVAI-GVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTC 479
GQ +T C + G P P W N + +P +TV S+G +L I V+ D G YTC
Sbjct: 904 GQQLTLPCTLLAGNPIPERRWIKNSAMLLQNPYITVRSDG---SLHIERVQLQDGGEYTC 960
Query: 480 EAMNARG 486
A N G
Sbjct: 961 VASNVAG 967
Score = 40.0 bits (92), Expect = 0.051
Identities = 22/63 (34%), Positives = 29/63 (46%), Gaps = 1/63 (1%)
Query: 424 VTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMN 483
V C A G+P P + W + + S GGR L + + SD G YTC A+N
Sbjct: 2029 VRLECEARGIPAPSLTWLKDGSPVSSFSNGLQVLSGGR-ILALTSAQISDTGRYTCVAVN 2087
Query: 484 ARG 486
A G
Sbjct: 2088 AAG 2090
Score = 40.0 bits (92), Expect = 0.051
Identities = 35/125 (28%), Positives = 47/125 (37%), Gaps = 3/125 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP + P + + V TC A GVP P I+W N I PR G
Sbjct: 3895 VPPSIADEPTDFLVTKHAPAV-ITCTASGVPFPSIHWTKN--GIRLLPRGDGYRILSSGA 3951
Query: 464 LIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFC 523
+ I + + G YTC A NA G + P P P + ++ LPC
Sbjct: 3952 IEILATQLNHAGRYTCVARNAAGSAHRHVTLHVHEPPVIQPQPSELHVILNNPILLPCEA 4011
Query: 524 FGITS 528
G S
Sbjct: 4012 TGTPS 4016
Score = 39.7 bits (91), Expect = 0.067
Identities = 34/122 (27%), Positives = 49/122 (40%), Gaps = 6/122 (4%)
Query: 369 GPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC---MPPQVVTPPR-ESIQASRGQTV 424
G R + T M + C + + FG +PP +V E ++ Q+V
Sbjct: 2438 GGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVLVPPHIVGENTLEDVKVKEKQSV 2497
Query: 425 TFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNA 484
T TC G P P I W + + + S GGR L I +V+ G YTC A +
Sbjct: 2498 TLTCEVTGNPVPEITWHKDGQPLQEDEAHHIIS-GGR-FLQITNVQVPHTGRYTCLASSP 2555
Query: 485 RG 486
G
Sbjct: 2556 AG 2557
Score = 39.3 bits (90), Expect = 0.087
Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 9/89 (10%)
Query: 407 QVVTPPR-------ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG 459
QV PP E I +G + + C+ G P P + W + + +TV++ G
Sbjct: 3429 QVFAPPNMDNSMGTEEITVLKGSSTSMACITDGTPAPSMAWLRDGQPLGLDAHLTVSTHG 3488
Query: 460 GRGTLIIRDVKESDQGAYTCEAMNARGMV 488
L + + D G YTC A N G V
Sbjct: 3489 --MVLQLLKAETEDSGKYTCIASNEAGEV 3515
Score = 38.9 bits (89), Expect = 0.11
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 9/87 (10%)
Query: 407 QVVTPPR-------ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG 459
+V+ PP E I + TC+A G+P P + W + +P +V G
Sbjct: 3522 KVLEPPHINGSEEHEEISVIVNNPLELTCIASGIPAPKMTWMKDGRPLPQTDQVQTL--G 3579
Query: 460 GRGTLIIRDVKESDQGAYTCEAMNARG 486
G L I + D G YTC A + G
Sbjct: 3580 GGEVLRISTAQVEDTGRYTCLASSPAG 3606
Score = 37.7 bits (86), Expect = 0.25
Identities = 27/104 (25%), Positives = 41/104 (39%), Gaps = 4/104 (3%)
Query: 386 FHCDEESDCPDRSDEFGC---MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRL 442
+ C + D EF +PP + + + + V C+A G+P P I W
Sbjct: 1803 YRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPNPSITWLK 1862
Query: 443 NWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ + + GR I + + E D G YTC A NA G
Sbjct: 1863 DDQPVNTAQGNLKIQSSGRVLQIAKTLLE-DAGRYTCVATNAAG 1905
Score = 37.4 bits (85), Expect = 0.33
Identities = 24/87 (27%), Positives = 39/87 (44%), Gaps = 8/87 (9%)
Query: 404 MPPQV----VTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG 459
+PP + TP + + + ++T C A G P+PI+ W + +P + E
Sbjct: 1637 VPPMIEGNLATPLNKQVVIAH--SLTLECKAAGNPSPILTWLKD--GVPVKANDNIRIEA 1692
Query: 460 GRGTLIIRDVKESDQGAYTCEAMNARG 486
G L I +E D+G Y C A + G
Sbjct: 1693 GGKKLEIMSAQEIDRGQYICVATSVAG 1719
Score = 37.4 bits (85), Expect = 0.33
Identities = 23/68 (33%), Positives = 27/68 (39%), Gaps = 3/68 (4%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G C G PTP I W I R+ + G G+L I D G YTC
Sbjct: 4364 GGNAILNCEVKGDPTPTIQWNRKGVDIEISHRIR---QLGNGSLAIYGTVNEDAGDYTCV 4420
Query: 481 AMNARGMV 488
A N G+V
Sbjct: 4421 ATNEAGVV 4428
Score = 37.0 bits (84), Expect = 0.43
Identities = 20/70 (28%), Positives = 30/70 (42%), Gaps = 2/70 (2%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G C G+P P + W G + P + + G L I++ ++ D G YTC
Sbjct: 716 GDITVMECKTSGIPPPQVKWFK--GDLELRPSTFLIIDPLLGLLKIQETQDLDAGDYTCV 773
Query: 481 AMNARGMVFG 490
A+N G G
Sbjct: 774 AINEAGRATG 783
Score = 35.8 bits (81), Expect = 0.96
Identities = 22/67 (32%), Positives = 31/67 (46%), Gaps = 6/67 (8%)
Query: 423 TVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKE--SDQGAYTCE 480
++ C A G P P INW N +P + + + G +IR V+ SD YTC
Sbjct: 3359 SINIECRATGTPPPQINWLKNGLPLPLSSHIRLLAAG----QVIRIVRAQVSDVAVYTCV 3414
Query: 481 AMNARGM 487
A N G+
Sbjct: 3415 ASNRAGV 3421
Score = 35.4 bits (80), Expect = 1.3
Identities = 30/116 (25%), Positives = 45/116 (38%), Gaps = 13/116 (11%)
Query: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAI 431
++ CV+TN H P ++ G M + V V C A
Sbjct: 1895 RYTCVATNAAGETQQHIQLHVHEPPSLEDAGKMLNETVLV---------SNPVQLECKAA 1945
Query: 432 GVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI-IRDVKESDQGAYTCEAMNARG 486
G P P+I W + + +T + RG +I I + SD G Y C A+N+ G
Sbjct: 1946 GNPVPVITWYKDNRLLSGSTSMTFLN---RGQIIDIESAQISDAGIYKCVAINSAG 1998
Score = 33.1 bits (74), Expect = 6.2
Identities = 22/68 (32%), Positives = 33/68 (48%), Gaps = 4/68 (5%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHI--PSHPRVTVTSEGGRGTLIIRDVKESDQGAYT 478
G ++ C + G+P P + W+ + S RV + S GGR L I ++SD Y+
Sbjct: 2211 GNLISLLCESSGIPPPNLIWKKKGSPVLTDSMGRVRILS-GGR-QLQISIAEKSDAALYS 2268
Query: 479 CEAMNARG 486
C A N G
Sbjct: 2269 CVASNVAG 2276
Score = 33.1 bits (74), Expect = 6.2
Identities = 29/104 (27%), Positives = 35/104 (33%), Gaps = 18/104 (17%)
Query: 1544 CAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDAT 1603
C G+ RT GL C+ E+ C Q NA G F C PGY
Sbjct: 5177 CGSGFRRTSDGLSCQDINECQ----------ESSPCHQRCFNAIGSFHCGCEPGY--QLK 5224
Query: 1604 AGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRC-TACEPGYT 1646
D C + P+ T GGY+C C G T
Sbjct: 5225 GRKCMDVNECRQNVCRPDQHCKNT-----RGGYKCIDLCPNGMT 5263
Score = 33.1 bits (74), Expect = 6.2
Identities = 20/63 (31%), Positives = 29/63 (46%), Gaps = 8/63 (12%)
Query: 3847 TCRD-RPCQNGGQC-HDSESS--SYVCVCPAGF----TGSRCEHSQALHCHPEACGPDAT 3898
TC D C+N C H+ +++ SY C+CP G+ G C+ CGP+
Sbjct: 5429 TCVDIDECENTDACQHECKNTFGSYQCICPPGYQLTHNGKTCQDIDECLEQNVHCGPNRM 5488
Query: 3899 CVN 3901
C N
Sbjct: 5489 CFN 5491
>gi|110349719 titin isoform N2-A [Homo sapiens]
Length = 33423
Score = 464 bits (1195), Expect = e-130
Identities = 511/2131 (23%), Positives = 813/2131 (38%), Gaps = 278/2131 (13%)
Query: 1674 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR---HQGSE 1730
+ P V+ A + QG S L C++SGSP W R D S + +
Sbjct: 6362 EPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVAL 6421
Query: 1731 LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVT 1790
L D+G YIC N + S + L +AP V ++ G+DV
Sbjct: 6422 LTINEASAEDSGDYICEAHN-GVGDASCSTALTVKAPP----VFTQKPSPVGALKGSDVI 6476
Query: 1791 FICTAKSKSPAYTLVWTR-----LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNM 1845
C S +P + +VW + ++ K + F+ L I N++ SD G Y C +N
Sbjct: 6477 LQCEI-SGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNE 6535
Query: 1846 FAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQP-------GQLAEFRCSATGSPTPTLE 1898
D T S V PP+ + G E R G ++
Sbjct: 6536 VGSD------------TCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISVV 6583
Query: 1899 WTGGPGGQLPAKAQIHGGI------LRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG 1952
W G + L+L + E ++ +Y+C+ + AG + AVL V
Sbjct: 6584 WLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVLE 6643
Query: 1953 GGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIAT 2009
R+ PE V G L C G P + W K+G L ++ T +A+
Sbjct: 6644 PA--RIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSKHHITFINKVAS 6701
Query: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIES-SSPSVTEGQTL 2068
L IP +D G Y + G + + V V SD PP I + G ++
Sbjct: 6702 LKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV---SDRIVPPSFIRKLKDVNAILGASV 6758
Query: 2069 DLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS------RLRLPQVSPADSGEYVCRVENG 2122
L C V+GSA V W++ G + + S L L + P+D+G Y C N
Sbjct: 6759 VLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANV 6818
Query: 2123 SGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQ 2182
+G E S ++V PS+ P S V G +L V+ G +
Sbjct: 6819 AGSDECSAVLTV----QEPPSFEQTPDSVE----------VLPGMSLTFTSVIRGTPPFK 6864
Query: 2183 VTWHKRGGSLPARHQTHGSL------LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIE 2236
V W K L + SL L L +V P +SG+Y C V +G + + ++
Sbjct: 6865 VKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVK 6924
Query: 2237 ASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV----- 2291
P V+ + +V G + L G V+W K + +
Sbjct: 6925 E-----PATFVK-RLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMT 6978
Query: 2292 -RGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSS 2350
+ + L I +++ D QY C N I + P IEP
Sbjct: 6979 EKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVL----------EPPYFIEPLEH 7028
Query: 2351 -QVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL------PVRHQTHGSLLRLYQASPADSG 2403
+ G+ L C V G +++W+K L ++ + + + L + + +D G
Sbjct: 7029 VEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVG 7088
Query: 2404 EYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQ 2463
EY C+ +SV AS V + A +P P + G + C + G
Sbjct: 7089 EYSCKA-DNSVGAVASSAVLVIKARKLP-----PFFARKLKDVHETLGFPVAFECRINGS 7142
Query: 2464 AHAQVTWHKRG------GSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVL 2517
QV+W+K G +L + + L++LQ + G+Y C GT +S
Sbjct: 7143 EPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAK 7202
Query: 2518 VTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKR------G 2571
+ + + V ++ S LA G + C V AP ITW K G
Sbjct: 7203 LILSEH-------EVPPFFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPG 7255
Query: 2572 GSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPP 2631
G+ + L + +V D+G+Y C+ SN AG S + +Q PP
Sbjct: 7256 GNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQ----------EPP 7305
Query: 2632 IRIESSSPT--VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSH------LRL 2683
I+ P+ V + + C + P+ + WYK + + S L +
Sbjct: 7306 RFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEM 7365
Query: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPI-RIESSSSHVAEGE 2742
H +SV DSG+Y C A+N + +S + V PI R + +G
Sbjct: 7366 HNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEP-----------PIFRKKPHPIETLKGA 7414
Query: 2743 TLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRG------SRLRLHHVSPADSGEYVCRVM 2796
+ L C + G V+W+K L S + + + + + +V AD GEY C+
Sbjct: 7415 DVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAADIGEYQCKAT 7474
Query: 2797 GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHA 2856
G + GS A+ P P + S G+ + L+ + G
Sbjct: 7475 NDVG--------SDTCVGSIALKAP-----PRFVKKLSDISTVVGKEVQLQTTIEGAEPI 7521
Query: 2857 QVTWHKRGG-------NLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEA-SVLV 2908
V W K G N+ + + L+ ++V PA++G+Y+CQ+ +G E + L
Sbjct: 7522 SVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQECFATLS 7581
Query: 2909 TIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR 2968
+EP++ I + S VT G T L C V G W+K G L +
Sbjct: 7582 VLEPAT------------IVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSD 7629
Query: 2969 HQ------THGSQLRLHLVSPADSGEYVCRAASGPGPEQ-EASFTV---TVPPSEGSSYR 3018
++ S L++ V+P+DSG Y + G + AS V TVPPS +
Sbjct: 7630 NKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCTASLQVSDRTVPPSFTRKLK 7689
Query: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN----VHISPNGS 3074
+ + G +C ++ G+ PIS+ W E+ ++ N
Sbjct: 7690 ETNGL-----------SGSSVVMECKVY-GSPPISVSWFHEGNEISSGRKYQTTLTDNTC 7737
Query: 3075 IITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC 3134
+T+ S+ G Y C+A+N G + L+V PP+ P+ P+ V G VT
Sbjct: 7738 ALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPD-PMDVLTGTNVTFTS 7796
Query: 3135 VSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTA 3194
+ G P S W + SS ++ L DS A L++ S +G Y C+ N G A
Sbjct: 7797 IVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVSNEAGKA 7856
Query: 3195 QKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPW 3254
+ + A + + ++E G L + TG+P ++ W K +
Sbjct: 7857 SCTTHLYIKAPA------KFVKRLNDYSIEKGKPLILEGTFTGTPPISVTWKKNGINVTP 7910
Query: 3255 QHRLEGDT------LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHA 3308
R T L IP +D+GQY C + +G + + + PPY E
Sbjct: 7911 SQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILILEPPYFVKQLEPV 7970
Query: 3309 SVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRAT----ARNEL--LHFERAAPEDSGR 3362
V G++ LQC GTP + W + + L T RN + L F + DSG
Sbjct: 7971 KVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGE 8030
Query: 3363 YRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCA 3422
Y C+ N VG A L VQ LP P+ S V +++G V F CA
Sbjct: 8031 YICKAENSVGEVSASTFLTVQ--EQKLP----PSFSRQLRDV-----QETVGLPVVFDCA 8079
Query: 3423 VPSDRGTQLRWFKEGGQLPPGHSVQ------DGVLRIQNLDQSCQGTYICQAHGPWGKAQ 3476
+ + W+K+G L +VQ L I D+S G Y C A P G A
Sbjct: 8080 ISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSAS 8139
Query: 3477 ASAQLVI-QALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG--- 3532
+SA+L++ + +IR + VVG + +FEC G +V+W+K +R G
Sbjct: 8140 SSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKY 8199
Query: 3533 ---IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL---PQIS--MPQEV 3584
+++ + + V+ D+GQY C A N G L ++ P + + + V
Sbjct: 8200 QISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPSFTKRLSETV 8259
Query: 3585 RVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE----NNMLMLP--SVRPQDAGT 3638
G++ +G ++W K + + P S E NN L+L DAG
Sbjct: 8260 EETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAGMNDAGL 8319
Query: 3639 YVCTATNRQGKVKAFAHLQVPE-RVVPYFTQ 3668
Y C +N G + + + E + P F Q
Sbjct: 8320 YTCKVSNDAGSALCTSSIVIKEPKKPPVFDQ 8350
Score = 461 bits (1187), Expect = e-129
Identities = 500/2148 (23%), Positives = 825/2148 (38%), Gaps = 269/2148 (12%)
Query: 1674 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR----HQGS 1729
+ P V+ A IV G S L C+++GSP W R + +P+ + R +
Sbjct: 5421 EPPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNE-HELPASDKYRMTFIDSVA 5479
Query: 1730 ELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAP----SKPITVTVEEQRSQSVRP 1785
+ ++ D+G +IC +N S + +++V E P PI T++
Sbjct: 5480 VIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLK--------- 5530
Query: 1786 GADVTFICTAKSKSPAYTLVWTR-----LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVC 1840
A+V+ C S +P + +VW + + K + +F+ + I NV SD G Y C
Sbjct: 5531 NAEVSLECEL-SGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHC 5589
Query: 1841 TGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWT 1900
N D T+ ++ + + S LTV G+ AE + S G+ ++W
Sbjct: 5590 KAQNEVGSDTCVCTVKLKEPPRFVSKLNS-----LTVVAGEPAELQASIEGAQPIFVQWL 5644
Query: 1901 GGPGGQLPAKAQI------HGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGG 1954
+ I + L+ EP + +Y+C+ + G + A L V
Sbjct: 5645 KEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEPA 5704
Query: 1955 GPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLL 2011
+ P V G T L C+ AG P ++ W K+G L + S I++L
Sbjct: 5705 VIVEKAGP--MTVTVGETCTLECKVAGTPELSVEWYKDGKLLTSSQKHKFSFYNKISSLR 5762
Query: 2012 IPAITTADAGFYLCVATSPAGTAQARIQVVVLSASD-ASPPPVKIESSSPSVTEGQTLDL 2070
I ++ DAG Y + G + V+ SD A PP + G + L
Sbjct: 5763 ILSVERQDAGTYTFQVQNNVGKSSC---TAVVDVSDRAVPPSFTRRLKNTGGVLGASCIL 5819
Query: 2071 NCVVAGSAHAQVTWYRR------GGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG 2124
C VAGS+ V W+ G + L+L + +D G Y C N +G
Sbjct: 5820 ECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDSSDMGNYTCVAANVAG 5879
Query: 2125 PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVT 2184
E ++V PS+ EP V G+ + V+ G +V
Sbjct: 5880 SDECRAVLTV----QEPPSFVK----------EPEPLEVLPGKNVTFTSVIRGTPPFKVN 5925
Query: 2185 WHK------RGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEAS 2238
W + +G + + L L + + SGEY C V +G + + ++
Sbjct: 5926 WFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKE- 5984
Query: 2239 VIPGPIPPVRIES-SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV------ 2291
P ++ S +V G+++ L G VTW K G ++ +
Sbjct: 5985 ------PAAFLKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDGFNITTSEKCNIVTTE 6038
Query: 2292 RGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQ 2351
+ L I ++ DAGQY C N EA V G + L P T+ +EP +
Sbjct: 6039 KTCILEILNSTKRDAGQYSCEIEN--EAG--RDVCGALVSTLEPPYFVTE---LEP--LE 6089
Query: 2352 VAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ------THGSLLRLYQASPADSGEY 2405
A G ++ L C V G V+W+K L + + + L + + DSGEY
Sbjct: 6090 AAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEY 6149
Query: 2406 VCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAH 2465
C+ S + + I+ + P+ + + G + L C + G A
Sbjct: 6150 TCKAENSIGTASSKTVFRIQER------QLPPSFARQLKDIEQTVGLPVTLTCRLNGSAP 6203
Query: 2466 AQVTWHKRGGSLPARHQVHGS------RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVT 2519
QV W++ G L + S L++LQ + SG+Y C GT +S +T
Sbjct: 6204 IQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNPLGTASSSARLT 6263
Query: 2520 IQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYK------RGGS 2573
++ I+ S + G + D C V P ITW K GG+
Sbjct: 6264 AREPKKSPFFD-------IKPVSIDVIAGESADFECHVTGAQPMRITWSKDNKEIRPGGN 6316
Query: 2574 LPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPP-- 2631
LRI +V DSG+Y C +N G S ++++ PP
Sbjct: 6317 YTITCVGNTPHLRILKVGKGDSGQYTCQATNDVGKDMCSAQLSVK----------EPPKF 6366
Query: 2632 IRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSH------LRLHQ 2685
++ +S +G+++ L C ++ P+ ++W++ L + + S L +++
Sbjct: 6367 VKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALLTINE 6426
Query: 2686 MSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLD 2745
S DSG+Y+C A+N + S ++V P S +G +
Sbjct: 6427 ASAEDSGDYICEAHNGVGDASCSTALTVKAPPVFTQKP----------SPVGALKGSDVI 6476
Query: 2746 LNCVVPGQAHAQVTWHKRGGSLPSHHQTR------GSRLRLHHVSPADSGEYVCRVMGSS 2799
L C + G +V W K + + + + + L + ++ +D GEY C+
Sbjct: 6477 LQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNLEASDVGEYHCKATNEV 6536
Query: 2800 GPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEP-SSSRVAEGQTLDLKCVVPGQAHAQV 2858
G S V + PP ++ S + G ++L+ +V G V
Sbjct: 6537 GSDTCSCSVKFK--------------EPPRFVKKLSDTSTLIGDAVELRAIVEGFQPISV 6582
Query: 2859 TWHKRGGNLPARHQ-------VHGPLLRLNQVSPADSGEYSCQVTGSSGTLEAS-VLVTI 2910
W K G + + + L+L ++SG+Y CQ+ +G E S VL +
Sbjct: 6583 VWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLTVL 6642
Query: 2911 EPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ 2970
EP+ P P VT G L CVV G W+K G L A +
Sbjct: 6643 EPARIIEKPEP------------MTVTTGNPFALECVVTGTPELSAKWFKDGRELSADSK 6690
Query: 2971 TH------GSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVI 3024
H + L++ +D G Y + G +++ TV+V S+ R+ P
Sbjct: 6691 HHITFINKVASLKIPCAEMSDKGLYSFEVKNSVG---KSNCTVSVHVSD----RIVPPSF 6743
Query: 3025 SIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL----EDNVHISPNGSIITIVG 3080
G +C + G+APIS+ W E+ + S N + +
Sbjct: 6744 IRKLKDVNAILGASVVLECRV-SGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSL 6802
Query: 3081 TRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEP 3140
PS+ G Y CVA+N G + L+V PP+ P+ V V G ++T V G P
Sbjct: 6803 LEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDS-VEVLPGMSLTFTSVIRGTP 6861
Query: 3141 RSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV 3200
+W + S E L D L++ +P ++G Y CL N G+A +
Sbjct: 6862 PFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHL 6921
Query: 3201 IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR--- 3257
V A A+ +VE G L + TG+P ++ W K + R
Sbjct: 6922 FVKEPA------TFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSI 6975
Query: 3258 --LEGDTLI-IPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGE 3314
E T++ I +D QY C + AG ++ V PPY EH GE
Sbjct: 6976 TMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEPPYFIEPLEHVEAVIGE 7035
Query: 3315 TVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL------LHFERAAPEDSGRYRCRVT 3368
LQC GTP + W + + L + + L + D G Y C+
Sbjct: 7036 PATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKAD 7095
Query: 3369 NKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRG 3428
N VG+ + A L+++ A +P P + +++G V F C +
Sbjct: 7096 NSVGAVASSAVLVIK-------ARKLP----PFFARKLKDVHETLGFPVAFECRINGSEP 7144
Query: 3429 TQLRWFKEGGQLPPGHSVQD------GVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLV 3482
Q+ W+K+G L ++Q L+I DQS G Y C A P G A +SA+L+
Sbjct: 7145 LQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLI 7204
Query: 3483 I--QALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG------IV 3534
+ +P +++ + +G + F+C G ++TW+K +RPG +V
Sbjct: 7205 LSEHEVPP-FFDLKPVSVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLV 7263
Query: 3535 QSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVR--VPAGSAA 3592
++ + + V DAGQY C A+N AG L VQ P+ E V
Sbjct: 7264 ENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFT 7323
Query: 3593 VFPCIASGYPTPDISWSKLDGSLPPDSRLENN------MLMLPSVRPQDAGTYVCTATNR 3646
+ C G P + W K + + S+ + +L + ++ +D+G Y C A N
Sbjct: 7324 RYECKIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNA 7383
Query: 3647 QGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRP 3694
G + L+V E P F + P+ P+ T+K A E ++ P
Sbjct: 7384 AGSASSSTSLKVKE--PPIFRKKPH---PIETLKGADVHLECELQGTP 7426
Score = 451 bits (1160), Expect = e-126
Identities = 496/2119 (23%), Positives = 809/2119 (38%), Gaps = 277/2119 (13%)
Query: 1670 PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR---- 1725
P + P +EV P +++ + + G+PP W R R + G +
Sbjct: 5893 PSFVKEPEPLEVLPGKNV-------TFTSVIRGTPPFKVNWFR-GARELVKGDRCNIYFE 5944
Query: 1726 HQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRP 1785
+EL ++ S +G Y C N + L V E + ++ SV P
Sbjct: 5945 DTVAELELFNIDISQSGEYTCVVSNNAGQASCTTRLFVKEPAA-----FLKRLSDHSVEP 5999
Query: 1786 GADVTFICTAKSKSPAYTLVWTR-----LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVC 1840
G + T P ++ W + + K + IL I N DAG Y C
Sbjct: 6000 GKSIILESTYTGTLPI-SVTWKKDGFNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSC 6058
Query: 1841 TGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWT 1900
N D A + TL P L G +C G+P T+ W
Sbjct: 6059 EIENEAGRDVCGALV-----STLEPPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWY 6113
Query: 1901 GG-----PGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGG 1955
G P + + L V D +Y C+A +S G ++ V +
Sbjct: 6114 KGDTKLRPTPEYRTYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQL 6173
Query: 1956 P----RVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIA 2008
P R E+T G V L CR G + W ++G L + + ++A
Sbjct: 6174 PPSFARQLKDIEQT---VGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVA 6230
Query: 2009 TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTL 2068
TL I + +G Y C A++P GTA + ++ + P I+ S V G++
Sbjct: 6231 TLKILQTDLSHSGQYSCSASNPLGTASSSARLTAREPKKS--PFFDIKPVSIDVIAGESA 6288
Query: 2069 DLNCVVAGSAHAQVTW------YRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENG 2122
D C V G+ ++TW R GG+ + LR+ +V DSG+Y C+ N
Sbjct: 6289 DFECHVTGAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATND 6348
Query: 2123 SGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQ 2182
G S +SV P + ++ +S +G+++ L C + G +
Sbjct: 6349 VGKDMCSAQLSV----KEPPKF---------VKKLEASKVAKQGESIQLECKISGSPEIK 6395
Query: 2183 VTWHKRGGSLPARHQTHGS------LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIE 2236
V+W + L + + S LL +++ + DSG+Y+C G S +T++
Sbjct: 6396 VSWFRNDSELHESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDASCSTALTVK 6455
Query: 2237 ASVIPGPIPPVRIESSSSTVA-EGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSR 2295
A PPV + S A +G + L C ++G +V W K R QVR S+
Sbjct: 6456 A-------PPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKD------RKQVRNSK 6502
Query: 2296 ------------LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPI 2343
L+I +D G+Y C+A+N + + T ++ +
Sbjct: 6503 KFKITSKHFDTSLHILNLEASDVGEYHCKATNEVGSD-------TCSCSVKFKEPPRFVK 6555
Query: 2344 RIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHK-RGGSLPVRHQTHGSL------LRLYQ 2396
++ +S+ + G ++L +V G V W K RG + T S L+L
Sbjct: 6556 KLSDTSTLI--GDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGS 6613
Query: 2397 ASPADSGEYVCRVLGSSVPLEASVLVTI-EPAGSVPALGVTPTVRIESSSSQVAEGQTLD 2455
++SG+Y+C++ + E S ++T+ EPA + + V G
Sbjct: 6614 PEASNSGKYICQIKNDAGMRECSAVLTVLEPARIIE----------KPEPMTVTTGNPFA 6663
Query: 2456 LNCLVAGQAHAQVTWHKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSS 2509
L C+V G W K G L A + H + L++ +D G Y V S
Sbjct: 6664 LECVVTGTPELSAKWFKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSV 6723
Query: 2510 GTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYK 2569
G +V V + R+ ++ +++ +A L G ++ L C V+ AP ++ W++
Sbjct: 6724 GKSNCTVSVHVSDRIVPP-----SFIRKLKDVNAIL--GASVVLECRVSGSAPISVGWFQ 6776
Query: 2570 RGGSLPSRHQIVGS------RLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 2623
G + S + S L + + P+D+G Y C +N AGS E S ++T+Q
Sbjct: 6777 DGNEIVSGPKCQSSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEP--- 6833
Query: 2624 HVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGS---- 2679
P S V+ G +L V+ P + W+K L + S
Sbjct: 6834 ------PSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDF 6887
Query: 2680 --HLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH 2737
L L ++ +SG+Y C N+ + + + V A + R+ S
Sbjct: 6888 VTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKEPA--------TFVKRLADFS-- 6937
Query: 2738 VAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT------RGSRLRLHHVSPADSGEY 2791
V G + L G V+W K + + + + L + + D +Y
Sbjct: 6938 VETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQY 6997
Query: 2792 VCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE-GQTLDLKCVV 2850
C + +G LV++ PP IEP A G+ L+C V
Sbjct: 6998 SCLIENEAGQDICEALVSVLE--------------PPYFIEPLEHVEAVIGEPATLQCKV 7043
Query: 2851 PGQAHAQVTWHKRGGNL---PA---RHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEA 2904
G +++W+K L PA + + + L +N+V +D GEYSC+ S G + +
Sbjct: 7044 DGTPEIRISWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVAS 7103
Query: 2905 SVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGS 2964
S ++ I+ P A L H T G + C + G QV+WYK G
Sbjct: 7104 SAVLVIKARKLPPFFARKL--------KDVHETLGFPVAFECRINGSEPLQVSWYKDGVL 7155
Query: 2965 LP--ARHQT----HGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYR 3018
L A QT + + L++ + G+Y C A++ P AS + + SE
Sbjct: 7156 LKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASN---PLGTASSSAKLILSEHEV-- 7210
Query: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN----VHISPNGS 3074
P + P S + G+ +FKC + G API + W N+E+ + + N +
Sbjct: 7211 --PPFFDLKPVSVDLALGESGTFKCHV-TGTAPIKITWAKDNREIRPGGNYKMTLVENTA 7267
Query: 3075 IITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC 3134
+T++ + G Y C ASN G L V PP E VK + EC
Sbjct: 7268 TLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGVQEPPRFIKKLEPSRIVKQDEFTRYEC 7327
Query: 3135 VSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTA 3194
G P W + + + + +DS AVL++ + D+G Y C A NA G+A
Sbjct: 7328 KIGGSPEIKVLWYKDETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSA 7387
Query: 3195 QKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRS 3250
T P + + + G L C G+P + W K LRS
Sbjct: 7388 SS------STSLKVKEPPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRS 7441
Query: 3251 PLPWQHRLEG--DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHA 3308
++ E ++ I V D G+Y C AT+ G + +++PP
Sbjct: 7442 GKKYKIMSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKAPPRFVKKLSDI 7501
Query: 3309 SVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA-------TARNELLHFERAAPEDSG 3361
S G+ VQLQ G P++ W + + + + L F R P ++G
Sbjct: 7502 STVVGKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAG 7561
Query: 3362 RYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHC 3421
+Y C++ N G E FA L V P T+ P+ + G + C
Sbjct: 7562 KYTCQIKNDAGMQECFATLSVLEP--------------ATIVEKPESIKVTTGDTCTLEC 7607
Query: 3422 AVPSDRGTQLRWFKEGGQLPPGHSVQDGV------LRIQNLDQSCQGTYICQAHGPWGKA 3475
V +WFK+G +L + + L+I N+ S G Y + P GK
Sbjct: 7608 TVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKD 7667
Query: 3476 QASAQLVIQ---ALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG 3532
+A L + PS ++ + + G +V EC G P V+W G + G
Sbjct: 7668 SCTASLQVSDRTVPPSFTRKLKET--NGLSGSSVVMECKVYGSPPISVSWFHEGNEISSG 7725
Query: 3533 ------IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ-ISMPQEVR 3585
+ + + + +E +D+G Y C ATN AG+ + L V+ P + P +
Sbjct: 7726 RKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMD 7785
Query: 3586 VPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR----LENNM--LMLPSVRPQDAGTY 3639
V G+ F I G P +SW K L P R LE+++ L L V +G Y
Sbjct: 7786 VLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEY 7845
Query: 3640 VCTATNRQGKVKAFAHLQV 3658
C +N GK HL +
Sbjct: 7846 TCIVSNEAGKASCTTHLYI 7864
Score = 436 bits (1120), Expect = e-121
Identities = 476/2100 (22%), Positives = 808/2100 (38%), Gaps = 283/2100 (13%)
Query: 1696 LRCQVSGSPPHYFYWSREDGRPVPSGTQ----QRHQGSELHFPSVQPSDAGVYICTCRNL 1751
L C+V+G+PP W + + R + S + R LH PSD G Y C N
Sbjct: 4974 LECEVTGTPPFEVTWLKNN-REIRSSKKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNE 5032
Query: 1752 HQSNTSRAELLVTEAPS--KPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRL 1809
S + + + E PS K I T +S + TF T SP ++ W +
Sbjct: 5033 GGSCSCSTRVALKEPPSFIKKIENTTTVLKSSA-------TFQSTVAG-SPPISITWLKD 5084
Query: 1810 -----HNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLS 1864
+ + +D L IR+V +G Y C N +++ A L VQ +
Sbjct: 5085 DQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQIV 5144
Query: 1865 APVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKA-----QIHGGILR 1919
S+ V C G+P ++W +P++ + + R
Sbjct: 5145 EKAKSVD-----VTEKDPMTLECVVAGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFR 5199
Query: 1920 LPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHA--GRTVRLYC 1977
+ +V D QY + + G A L V P + + T++ G ++ + C
Sbjct: 5200 IQSVMKQDSGQYTFKVENDFGSSSCDAYLRVLDQNIPP-SFTKKLTKMDKVLGSSIHMEC 5258
Query: 1978 RAAGVPSATITWRKEGGSLPPQAR-----SERTDIATLLIPAITTADAGFYLCVATSPAG 2032
+ +G + W K+G + A+ ER+ +L + + D Y C ++ AG
Sbjct: 5259 KVSGSLPISAQWFKDGKEISTSAKYRLVCHERS--VSLEVNNLELEDTANYTCKVSNVAG 5316
Query: 2033 TAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP 2092
+ V PP ++ T++ ++ G+ ++ W++ L
Sbjct: 5317 DDACSGILTV-----KEPPSFLVKPGRQQAIPDSTVEFKAILKGTPPFKIKWFKDDVELV 5371
Query: 2093 PHTQ----VHGSR--LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTP 2146
+ + GS L L V + +G+Y C V N G + + V T
Sbjct: 5372 SGPKCFIGLEGSTSFLNLYSVDASKTGQYTCHVTNDVGSDSCTTMLLV----------TE 5421
Query: 2147 VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGS----- 2201
P + + +S V G + L C + G +V W + LPA + +
Sbjct: 5422 PPKFVKKLE---ASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSV 5478
Query: 2202 -LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQ 2260
+++++ ++ DSG+++C +G S V ++ + PP+ ++ V+
Sbjct: 5479 AVIQMNNLSTEDSGDFICEAQNPAGSTSCSTKVIVKEPPVFSSFPPIVETLKNAEVS--- 5535
Query: 2261 TLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR------GSRLYIFQASPADAGQYVCRAS 2314
L C ++G +V WYK L + + + + ++I +D G+Y C+A
Sbjct: 5536 ---LECELSGTPPFEVVWYKDKRQLRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQ 5592
Query: 2315 NGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTW 2374
N + + V L P + +S V G+ +L + G V W
Sbjct: 5593 NEVGSDTCVCTV-----KLKEPPRFVSKL----NSLTVVAGEPAELQASIEGAQPIFVQW 5643
Query: 2375 HKR-------GGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLE-ASVLVTIEP 2426
K ++ + + + L+ +A PA++G+Y+C++ E + L+ +EP
Sbjct: 5644 LKEKEEVIRESENIRITFVENVATLQFAKAEPANAGKYICQIKNDGGMRENMATLMVLEP 5703
Query: 2427 AGSVPALG-VTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHG 2485
A V G +T TV G+T L C VAG V W+K G L Q H
Sbjct: 5704 AVIVEKAGPMTVTV-----------GETCTLECKVAGTPELSVEWYK-DGKLLTSSQKHK 5751
Query: 2486 -------SRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRI 2538
S LR+L V D+G Y +V + G + +V + R + ++ R+
Sbjct: 5752 FSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDVSDR-----AVPPSFTRRL 5806
Query: 2539 ESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS--RHQIVGS----RLRIPQVTP 2592
+++ L G + L C VA +P ++ W+ + S ++Q S L++ +
Sbjct: 5807 KNTGGVL--GASCILECKVAGSSPISVAWFHEKTKIVSGAKYQTTFSDNVCTLQLNSLDS 5864
Query: 2593 ADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT-VVEGQTLDLNC 2651
+D G Y C +N AGS E ++T+Q PP ++ P V+ G+ +
Sbjct: 5865 SDMGNYTCVAANVAGSDECRAVLTVQ----------EPPSFVKEPEPLEVLPGKNVTFTS 5914
Query: 2652 VVARQPQAIITWYK------RGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDAL 2705
V+ P + W++ +G + + L L + ++ SGEY C +NN
Sbjct: 5915 VIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAELELFNIDISQSGEYTCVVSNNAGQA 5974
Query: 2706 EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAE-GETLDLNCVVPGQAHAQVTWHKRG 2764
+ + V A ++ S H E G+++ L G VTW K G
Sbjct: 5975 SCTTRLFVKEPAAF-----------LKRLSDHSVEPGKSIILESTYTGTLPISVTWKKDG 6023
Query: 2765 GSLPSHHQT------RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLV-TIEASGSSA 2817
++ + + + L + + + D+G+Y C + +G LV T+E
Sbjct: 6024 FNITTSEKCNIVTTEKTCILEILNSTKRDAGQYSCEIENEAGRDVCGALVSTLE------ 6077
Query: 2818 VHVPAPGGAPPIRI-EPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHG- 2875
PP + E A G ++ L+C V G V+W+K L +
Sbjct: 6078 ---------PPYFVTELEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTY 6128
Query: 2876 -----PLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIE 2930
L N+V+ DSGEY+C+ S GT + + I+ P A L IE
Sbjct: 6129 FTNNVATLVFNKVNINDSGEYTCKAENSIGTASSKTVFRIQERQLPPSFARQLKD---IE 6185
Query: 2931 ASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRG------GSLPARHQTHGSQLRLHLVSPA 2984
T G + L C + G A QV WY+ G +L + + L++ +
Sbjct: 6186 Q-----TVGLPVTLTCRLNGSAPIQVCWYRDGVLLRDDENLQTSFVDNVATLKILQTDLS 6240
Query: 2985 DSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCL 3044
SG+Y C A++ G ++ P +SP I P S V G+ A F+C
Sbjct: 6241 HSGQYSCSASNPLGTASSSARLTAREPK-------KSPFFDIKPVSIDVIAGESADFECH 6293
Query: 3045 IHDGAAPISLEWKTRNQELEDNVHISPNGSI-ITIVGTRP---------SNHGTYRCVAS 3094
+ GA P+ + W +DN I P G+ IT VG P + G Y C A+
Sbjct: 6294 V-TGAQPMRITWS------KDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQAT 6346
Query: 3095 NAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPA 3154
N G LSV PP E K G+++ LEC +G P W R S
Sbjct: 6347 NDVGKDMCSAQLSVKEPPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELH 6406
Query: 3155 KLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV 3214
+ + ++S A+L I+ A D+G Y+C A N +G A T P
Sbjct: 6407 ESWKYNMSFINSVALLTINEASAEDSGDYICEAHNGVGDAS------CSTALTVKAPPVF 6460
Query: 3215 QAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE------GDTLIIPRV 3268
+ + + G L+C +G+P + W K R + + + +L I +
Sbjct: 6461 TQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLHILNL 6520
Query: 3269 AQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPL 3328
D G+Y C AT+ G + + + PP S G+ V+L+ + G P+
Sbjct: 6521 EASDVGEYHCKATNEVGSDTCSCSVKFKEPPRFVKKLSDTSTLIGDAVELRAIVEGFQPI 6580
Query: 3329 TFQWSR-----VGSSLPGRATARNELLHFERAAPE--DSGRYRCRVTNKVGSAEAFAQLL 3381
+ W + + S R + + + + +PE +SG+Y C++ N G E A L
Sbjct: 6581 SVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYICQIKNDAGMRECSAVLT 6640
Query: 3382 VQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP 3441
V P + P+ T + G C V +WFK+G +L
Sbjct: 6641 VLEP--------------ARIIEKPEPMTVTTGNPFALECVVTGTPELSAKWFKDGRELS 6686
Query: 3442 PG--HSV----QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI--QALPSVLINI 3493
H + + L+I + S +G Y + GK+ + + + + +P I
Sbjct: 6687 ADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHVSDRIVPPSFIRK 6746
Query: 3494 RTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG------IVQSGGVVRIAHVEL 3547
V ++G +V EC G V W + G + G ++ + ++ +E
Sbjct: 6747 LKDV-NAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCTLNLSLLEP 6805
Query: 3548 ADAGQYRCTATNAAGTTQSHVLLLVQALPQISM-PQEVRVPAGSAAVFPCIASGYPTPDI 3606
+D G Y C A N AG+ + +L VQ P P V V G + F + G P +
Sbjct: 6806 SDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPDSVEVLPGMSLTFTSVIRGTPPFKV 6865
Query: 3607 SWSKLDGSLPPDSRLENNM------LMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE 3660
W K L P ++ L L V+P ++G Y C TN G HL V E
Sbjct: 6866 KWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDAGSASCTTHLFVKE 6925
Score = 409 bits (1050), Expect = e-113
Identities = 499/2118 (23%), Positives = 783/2118 (36%), Gaps = 275/2118 (12%)
Query: 1671 ETNQAPLVV-EVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS 1729
E AP++ ++ P V G C++ +P F W + GR + + + S
Sbjct: 3451 EMKAAPVIKRKIEPLE--VALGHLAKFTCEIQSAPNVRFQWFKA-GREIYESDKCSIRSS 3507
Query: 1730 E----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRP 1785
+ L Q D G Y C N + S + A L VTEA P T + +S +
Sbjct: 3508 KYISSLEILRTQVVDCGEYTCKASNEYGSVSCTATLTVTEA--YPPTF-LSRPKSLTTFV 3564
Query: 1786 GADVTFICTAKSKSPAYTLVWTRLHNGKLPT---RAMDFNG--ILTIRNVQLSDAGTYVC 1840
G FICT +P +W + P+ R D IL + N+ + D G Y C
Sbjct: 3565 GKAAKFICTVTG-TPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSC 3623
Query: 1841 TGSNMFAMDQGTATLHVQASGTLSAP--VVSIHPPQLTVQPGQLAEFRCSATGSPTPTLE 1898
SN F D A L + + P + + P Q + + C T+
Sbjct: 3624 KASNKFGADICQAELII-----IDKPHFIKELEPVQSAIN--KKVHLECQVDEDRKVTVT 3676
Query: 1899 WTGG-----PGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGG 1953
W+ PG + L +P + D Y+C A + AG A + V
Sbjct: 3677 WSKDGQKLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREP 3736
Query: 1954 GGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDI---ATL 2010
+V P + G + RL+C+ G P +TW K L + A L
Sbjct: 3737 PSFVKKVDPSYLML-PGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAIL 3795
Query: 2011 LIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPS-VTEGQTLD 2069
I + D+G Y C A + G+ ++V+ PP I++ P+ + G
Sbjct: 3796 DITDVKVEDSGSYSCEAVNDVGSDSCSTEIVI------KEPPSFIKTLEPADIVRGTNAL 3849
Query: 2070 LNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSR------------LRLPQVSPADSGEYVC 2117
L C V+G+ +++W++ Q+ S+ L + + AD GEY C
Sbjct: 3850 LQCEVSGTGPFEISWFK------DKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYEC 3903
Query: 2118 RVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPG 2177
V N G T H P++ + GQT+ L V G
Sbjct: 3904 VVANEVGKCGCMAT----HLLKEPPTFVK----------KVDDLIALGGQTVTLQAAVRG 3949
Query: 2178 QAHAQVTWHK------RGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEA-- 2229
VTW K G + ++L + V + G+Y C +G +
Sbjct: 3950 SEPISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVG 4009
Query: 2230 SVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARH 2289
++V A +I R E T + TL+ + VAG + WYK G L A
Sbjct: 4010 ELIVKEPAKIIE------RAELIQVTAGDPATLEYT--VAGTPELKPKWYKDGRPLVASK 4061
Query: 2290 QVRGS------RLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPI 2343
+ R S +L + A D+GQY SN + +S T ++A T+P+
Sbjct: 4062 KYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIA--PFFTKPL 4119
Query: 2344 RIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSL------LRLYQA 2397
R + V G T L+C + G +V+W K G + + + L + +
Sbjct: 4120 R---NVDSVVNG-TCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEIIRV 4175
Query: 2398 SPADSGEYVCRVLGSSVPLEAS-VLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDL 2456
D+G + CR S ++S L+ EP P+ + S V G + L
Sbjct: 4176 DMNDAGNFTCRATNSVGSKDSSGALIVQEP----------PSFVTKPGSKDVLPGSAVCL 4225
Query: 2457 NCLVAGQAHAQVTWHK------RGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSG 2510
G + W K GGS + S L L V +DSG Y C+V +G
Sbjct: 4226 KSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAG 4285
Query: 2511 TQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKR 2570
E S + +++ + + ++E S L G L C V P ITW+
Sbjct: 4286 GVECSANLFVKEPAT--------FVEKLEPSQL-LKKGDATQLACKVTGTPPIKITWFAN 4336
Query: 2571 GGSLP--SRHQIV----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSH 2624
+ S+H++ + LR+ V DSGEY+C N AGS S IV ++ S
Sbjct: 4337 DREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKES---- 4392
Query: 2625 VPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH------QTHG 2678
P E V++ + L VA P ITW+K L S Q H
Sbjct: 4393 -----PYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHL 4447
Query: 2679 SHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHV 2738
L++ + AD+GEY CR N + S + S + P S +IES+SS
Sbjct: 4448 VSLQILKFVAADAGEYQCRVTNEV----GSSICSARVTLREPP----SFIKKIESTSS-- 4497
Query: 2739 AEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYV 2792
G T + G VTW K + R + L L + G+YV
Sbjct: 4498 LRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYV 4557
Query: 2793 CRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPG 2852
C+ +G S L++++ + I E S V +G L+ G
Sbjct: 4558 CQAKNDAGIQRCSALLSVKEPAT-------------ITEEAVSIDVTQGDPATLQVKFSG 4604
Query: 2853 QAHAQVTWHKRGGNLP--ARHQVHGP----LLRLNQVSPADSGEYSCQVTGSSGTLEASV 2906
W K G L +++++ +L++ DSGEY+ +V G
Sbjct: 4605 TKEITAKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKA 4664
Query: 2907 LVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLP 2966
+ + I P + + +G +DL C+V G + W+K +
Sbjct: 4665 RINVLDL----IIPPSFTKKL----KKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEIS 4716
Query: 2967 ARHQ------THGSQLRLHLVSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSEGSSYRL 3019
A + + + L + + DSG Y C A + G Q TV PP Y +
Sbjct: 4717 ASEKYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPP-----YFV 4771
Query: 3020 RSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELED----NVHISPNGSI 3075
P P++ VQ K L+ G AP++++W N+EL +V +
Sbjct: 4772 EKPQSQDVNPNTRVQ------LKALV-GGTAPMTIKWFKDNKELHSGAARSVWKDDTSTS 4824
Query: 3076 ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECV 3135
+ + + ++ GTY C SN G A S L V PP P + ++ G++ T EC
Sbjct: 4825 LELFAAKATDSGTYICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQ 4884
Query: 3136 SAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQ 3195
G P+ W + +++ +D A QIS A+ ++GTYVC A+N GTA
Sbjct: 4885 ITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTAS 4944
Query: 3196 KQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSP 3251
+E+ V P E + V L C TG+P + W K +RS
Sbjct: 4945 CSIELKVKE------PPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSS 4998
Query: 3252 LPW--QHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHAS 3309
+ R+ L I + D+G+Y C ++ G + + ++ PP E+ +
Sbjct: 4999 KKYTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEPPSFIKKIENTT 5058
Query: 3310 VQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL------LHFERAAPEDSGRY 3363
+ Q G+PP++ W + L L SGRY
Sbjct: 5059 TVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRY 5118
Query: 3364 RCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAV 3423
C+ N+ G +A LLVQ P + +V VT + + C V
Sbjct: 5119 TCQAKNESGVERCYAFLLVQEPAQIVE-------KAKSVDVTEK-------DPMTLECVV 5164
Query: 3424 PSDRGTQLRWFKEGGQLPPGH----SVQDGV--LRIQNLDQSCQGTYICQAHGPWGKAQA 3477
+++W K+G Q+ P S ++ V RIQ++ + G Y + +G +
Sbjct: 5165 AGTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVENDFGSSSC 5224
Query: 3478 SAQLVI--QALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHL------ 3529
A L + Q +P T + V+G ++ EC G W K G +
Sbjct: 5225 DAYLRVLDQNIPPSFTKKLTKMDK-VLGSSIHMECKVSGSLPISAQWFKDGKEISTSAKY 5283
Query: 3530 RPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ-ISMPQEVRVPA 3588
R + + + ++EL D Y C +N AG +L V+ P + P +
Sbjct: 5284 RLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKPGRQQAIP 5343
Query: 3589 GSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL------ENNMLMLPSVRPQDAGTYVCT 3642
S F I G P I W K D L + + L L SV G Y C
Sbjct: 5344 DSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLYSVDASKTGQYTCH 5403
Query: 3643 ATNRQGKVKAFAHLQVPE 3660
TN G L V E
Sbjct: 5404 VTNDVGSDSCTTMLLVTE 5421
Score = 407 bits (1047), Expect = e-113
Identities = 447/1934 (23%), Positives = 749/1934 (38%), Gaps = 248/1934 (12%)
Query: 1679 VEVHPARSIVPQ-------------GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR 1725
V VH + IVP G S L C+VSGS P W +DG + SG + +
Sbjct: 6730 VSVHVSDRIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWF-QDGNEIVSGPKCQ 6788
Query: 1726 HQGSE----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQ 1781
SE L+ ++PSD G+Y C N+ S+ A L V E PS T S
Sbjct: 6789 SSFSENVCTLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPD-----SV 6843
Query: 1782 SVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAM-----DFNGILTIRNVQLSDAG 1836
V PG +TF + +P + + W + +P + DF L + VQ ++G
Sbjct: 6844 EVLPGMSLTFTSVIRG-TPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESG 6902
Query: 1837 TYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPT 1896
Y C +N T L V+ T + +V+ G + TG+P +
Sbjct: 6903 DYSCLVTNDAGSASCTTHLFVKEPATFVKRLADF-----SVETGSPIVLEATYTGTPPIS 6957
Query: 1897 LEWTG-----GPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVH 1951
+ W + IL + D AQY C + AGQ + A++ V
Sbjct: 6958 VSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVL 7017
Query: 1952 GGGGPRVQVSP-ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL---PPQARSERTDI 2007
P + P E + G L C+ G P I+W KE L P + ++
Sbjct: 7018 E---PPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNV 7074
Query: 2008 ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQT 2067
A+L+I + +D G Y C A + G A A V+V+ A PP + T G
Sbjct: 7075 ASLVINKVDHSDVGEYSCKADNSVG-AVASSAVLVIKARKL-PPFFARKLKDVHETLGFP 7132
Query: 2068 LDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS------RLRLPQVSPADSGEYVCRVEN 2121
+ C + GS QV+WY+ G L + S L++ Q + G+Y C N
Sbjct: 7133 VAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNCSASN 7192
Query: 2122 GSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHA 2181
G AS + ++ H P + ++P S +A G++ C V G A
Sbjct: 7193 PLGT--ASSSAKLILSEHEVPPF---------FDLKPVSVDLALGESGTFKCHVTGTAPI 7241
Query: 2182 QVTWHKR------GGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
++TW K GG+ + + L + +V D+G+Y C+ +G S + +
Sbjct: 7242 KITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGV 7301
Query: 2236 EASVIPGPIPPVRIES--SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG 2293
+ PP I+ S V + + C + G +V WYK + + R
Sbjct: 7302 QE-------PPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKFRM 7354
Query: 2294 SR------LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEP 2347
S L + S D+G Y C A N G+ ++ + R +P
Sbjct: 7355 SFVDSVAVLEMHNLSVEDSGDYTCEAHNA---------AGSASSSTSLKVKEPPIFRKKP 7405
Query: 2348 SSSQVAEGQTLDLNCVVPGQSHAQVTWHK------RGGSLPVRHQTHGSLLRLYQASPAD 2401
+ +G + L C + G V+W+K G + + + + + AD
Sbjct: 7406 HPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNVDAAD 7465
Query: 2402 SGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVA 2461
GEY C+ + V + V GS+ AL P + S G+ + L +
Sbjct: 7466 IGEYQCKAT-NDVGSDTCV-------GSI-ALKAPPRFVKKLSDISTVVGKEVQLQTTIE 7516
Query: 2462 GQAHAQVTWHKRGGSLPAR-------HQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEA 2514
G V W K G + + + + L+ +V PA++G+Y C++ +G QE
Sbjct: 7517 GAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAGMQEC 7576
Query: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL 2574
+++ + + + + S + G T L C VA + W+K G L
Sbjct: 7577 FATLSVLEPAT----------IVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKEL 7626
Query: 2575 PSRHQIV------GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSV 2628
S ++ S L+I V P+DSG Y V N G + S ++Q S + PS
Sbjct: 7627 TSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVG--KDSCTASLQVSDRTVPPSF 7684
Query: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS--RHQT----HGSHLR 2682
+ ++ + + G ++ + C V P ++W+ G + S ++QT + L
Sbjct: 7685 TRKLKETNG----LSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCALT 7740
Query: 2683 LHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGE 2742
++ + +DSG+Y C A N + E S ++V P V G
Sbjct: 7741 VNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKP----------DPMDVLTGT 7790
Query: 2743 TLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCRVM 2796
+ +V G V+W K L + S L L V + SGEY C V
Sbjct: 7791 NVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVS 7850
Query: 2797 GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHA 2856
+G +AS ++ +++ AP R+ S + +G+ L L+ G
Sbjct: 7851 NEAG----------KASCTTHLYIKAPAKFVK-RLNDYS--IEKGKPLILEGTFTGTPPI 7897
Query: 2857 QVTWHKRGGNLPARHQVH------GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTI 2910
VTW K G N+ + + +L + + D+G+Y+C + +SG S + I
Sbjct: 7898 SVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKDSCSAQILI 7957
Query: 2911 EPSSPGPIPAPGLAQPIYI-EASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL---- 2965
L P ++ + V+ G + L C + G V+WYK L
Sbjct: 7958 ------------LEPPYFVKQLEPVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTT 8005
Query: 2966 --PARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVT----VPPSEGSSYRL 3019
+ + + L + V DSGEY+C+A + G ++F +PPS S +L
Sbjct: 8006 TYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPS--FSRQL 8063
Query: 3020 RSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISP----NGSI 3075
R ++ P F C I G+ PIS+ W + L+D+ ++ N +
Sbjct: 8064 RDVQETVGLP---------VVFDCAI-SGSEPISVSWYKDGKPLKDSPNVQTSFLDNTAT 8113
Query: 3076 ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV---HGPPTVSVLPEGPVWVKVGKAVTL 3132
+ I T S G Y C A+N G A S L + PP + PV VG++
Sbjct: 8114 LNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNPPFFDIRL-APVDAVVGESADF 8172
Query: 3133 ECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALG 3192
EC G W + S + +++ A L + D+G Y C A N +G
Sbjct: 8173 ECHVTGTQPIKVSWAKDSREIRSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVG 8232
Query: 3193 TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK----L 3248
++ + + P + +E E T G++ L GS T+ W K +
Sbjct: 8233 KDSCTAQLNIKERLIPPSFTKRLSETVEET--EGNSFKLEGRVAGSQPITVAWYKNNIEI 8290
Query: 3249 RSPLPWQHRLEGDTLIIP--RVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE 3306
+ + + +TL++ + D+G Y C ++ AG A T + ++ P +
Sbjct: 8291 QPTSNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQ 8350
Query: 3307 H---ASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAAP 3357
H +V GE VQL C G+ P+ QW + G + + +L A
Sbjct: 8351 HLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAK 8410
Query: 3358 EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASV 3417
DSG Y C+ +N GS +++ ++ P PAT A V+ + + +
Sbjct: 8411 ADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTT 8470
Query: 3418 EFHCA------VPSDRGTQLRW--FKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3469
A +P+ + T+ +W +GG++ + L I++ ++ G Y C A
Sbjct: 8471 ATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAF 8530
Query: 3470 GPWGKAQASAQLVI 3483
G+ +++ L +
Sbjct: 8531 NEHGEIESNVNLQV 8544
Score = 407 bits (1045), Expect = e-112
Identities = 478/2115 (22%), Positives = 806/2115 (38%), Gaps = 276/2115 (13%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR----HQGSELHFPSVQPSDAGVYIC 1746
G + LR V G P W ++ G + R + L S + S++G YIC
Sbjct: 6565 GDAVELRAIVEGFQPISVVWLKDRGEVIRESENTRISFIDNIATLQLGSPEASNSGKYIC 6624
Query: 1747 TCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVW 1806
+N A L V E P++ +E+ +V G C +P + W
Sbjct: 6625 QIKNDAGMRECSAVLTVLE-PAR----IIEKPEPMTVTTGNPFALECVVTG-TPELSAKW 6678
Query: 1807 TR-----LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASG 1861
+ + K ++ L I ++SD G Y N T ++HV S
Sbjct: 6679 FKDGRELSADSKHHITFINKVASLKIPCAEMSDKGLYSFEVKNSVGKSNCTVSVHV--SD 6736
Query: 1862 TLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW-------TGGPGGQLPAKAQIH 1914
+ P + G C +GS ++ W GP Q +
Sbjct: 6737 RIVPPSFIRKLKDVNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVC 6796
Query: 1915 GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVR 1974
L L +EP+D Y C A + AG AVL V P + +P+ +V G ++
Sbjct: 6797 --TLNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEP--PSFEQTPDSVEVLPGMSLT 6852
Query: 1975 LYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITTADAGFYLCVATSPA 2031
G P + W K L P S + L + + ++G Y C+ T+ A
Sbjct: 6853 FTSVIRGTPPFKVKWFKGSRELVPGESCNISLEDFVTELELFEVQPLESGDYSCLVTNDA 6912
Query: 2032 GTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL 2091
G+A + V P + SV G + L G+ V+W + +
Sbjct: 6913 GSASCTTHLFV-----KEPATFVKRLADFSVETGSPIVLEATYTGTPPISVSWIKDEYLI 6967
Query: 2092 PPHTQVH------GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYT 2145
+ + L + + + D +Y C +EN +G VSVL
Sbjct: 6968 SQSERCSITMTEKSTILEILESTIEDYAQYSCLIENEAGQDICEALVSVLEP-------- 7019
Query: 2146 PVPGSTRPIRIEPSSSHVAE--GQTLDLNCVVPGQAHAQVTWHKRGGSL---PA---RHQ 2197
P IEP HV G+ L C V G +++W+K L PA + +
Sbjct: 7020 -------PYFIEPLE-HVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFK 7071
Query: 2198 THGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVA 2257
+ + L +++V +D GEY C + G + +S ++ I+A +P P +++ T+
Sbjct: 7072 NNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKARKLP-PFFARKLKDVHETL- 7129
Query: 2258 EGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGS------RLYIFQASPADAGQYVC 2311
G + C + G QV+WYK G L ++ S L I Q + GQY C
Sbjct: 7130 -GFPVAFECRINGSEPLQVSWYKDGVLLKDDANLQTSFVHNVATLQILQTDQSHIGQYNC 7188
Query: 2312 RASNGMEASITVTVTGTQGANLAYPAGSTQPI-RIEPSSSQVAEGQTLDLNCVVPGQSHA 2370
ASN + T + A L P ++P S +A G++ C V G +
Sbjct: 7189 SASNPLG-------TASSSAKLILSEHEVPPFFDLKPVSVDLALGESGTFKCHVTGTAPI 7241
Query: 2371 QVTWHKR------GGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTI 2424
++TW K GG+ + + + L + + D+G+Y C + S + +
Sbjct: 7242 KITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYASNIAGKDSCSAQLGV 7301
Query: 2425 -EPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQV 2483
EP + L S V + + C + G +V W+K + +
Sbjct: 7302 QEPPRFIKKL---------EPSRIVKQDEFTRYECKIGGSPEIKVLWYKDETEIQESSKF 7352
Query: 2484 HGSR------LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPV- 2536
S L + ++ DSG+Y C ++G+ +S + +++ P+
Sbjct: 7353 RMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKEP-----------PIF 7401
Query: 2537 RIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS--RHQIVGSR----LRIPQV 2590
R + G + L C + P ++WYK L S +++I+ + I V
Sbjct: 7402 RKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIHILNV 7461
Query: 2591 TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLN 2650
AD GEY C +N GS T GS + P P + S + V G+ + L
Sbjct: 7462 DAADIGEYQCKATNDVGSD------TCVGSIALKAP---PRFVKKLSDISTVVGKEVQLQ 7512
Query: 2651 CVVARQPQAIITWYKRGGSLPSR-------HQTHGSHLRLHQMSVADSGEYVCRANNNID 2703
+ + W+K G + + + + L+ ++ A++G+Y C+ N+
Sbjct: 7513 TTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPANAGKYTCQIKNDAG 7572
Query: 2704 ALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKR 2763
E +SV A P S V G+T L C V G W K
Sbjct: 7573 MQECFATLSVLEPATIVEKP----------ESIKVTTGDTCTLECTVAGTPELSTKWFKD 7622
Query: 2764 GGSLPSHHQ------TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSA 2817
G L S ++ + S L++ +V+P+DSG Y V G + S +++ S +
Sbjct: 7623 GKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVG--KDSCTASLQVSDRT- 7679
Query: 2818 VHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL 2877
VP P + + G ++ ++C V G V+W G + + + L
Sbjct: 7680 --VP-----PSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTL 7732
Query: 2878 ------LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTI-EPSSPGPIPAPGLAQPIYIE 2930
L +N + +DSG+Y+C T +G+ E S +T+ EP S P P
Sbjct: 7733 TDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDP--------- 7783
Query: 2931 ASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGS------QLRLHLVSPA 2984
V G + +V G V+W+K L + + S +L L V +
Sbjct: 7784 ---MDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTS 7840
Query: 2985 DSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCL 3044
SGEY C ++ G +AS T + + + R SI+ + +G
Sbjct: 7841 QSGEYTCIVSNEAG---KASCTTHLYIKAPAKFVKRLNDYSIEKGKPLILEGT------- 7890
Query: 3045 IHDGAAPISLEWKTRNQELED----NVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVA 3100
G PIS+ WK + N+ + +I+ I + + G Y C NA G
Sbjct: 7891 -FTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIENASGKD 7949
Query: 3101 QSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRT 3160
+ + PP E PV V VG + +L+C AG P W + +
Sbjct: 7950 SCSAQILILEPPYFVKQLE-PVKVSVGDSASLQCQLAGTPEIGVSWYKGDTKLRPTTTYK 8008
Query: 3161 YGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAE 3220
++ A L + +D+G Y+C A+N++G + V + P + Q + +
Sbjct: 8009 MHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQEQKLPPSFSR-QLRDVQ 8067
Query: 3221 LTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGD------TLIIPRVAQQDSG 3274
TV G C+ +GS ++ W K PL ++ TL I + + +G
Sbjct: 8068 ETV--GLPVVFDCAISGSEPISVSWYKDGKPLKDSPNVQTSFLDNTATLNIFKTDRSLAG 8125
Query: 3275 QYICNATSPAGHAEAT---IILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQ 3331
QY C AT+P G A ++ I+ ++PP+ GE+ +C GT P+
Sbjct: 8126 QYSCTATNPIGSASSSARLILTEGKNPPFFDIRLAPVDAVVGESADFECHVTGTQPIKVS 8185
Query: 3332 WSRVGSSLPGRATARNELLHFERAA--------PEDSGRYRCRVTNKVGSAEAFAQLLVQ 3383
W++ + R+ + ++ + E +A DSG+Y C N+VG AQL
Sbjct: 8186 WAKDSREI--RSGGKYQISYLENSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQL--- 8240
Query: 3384 GPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG 3443
++ IP T + T + ET+ G S + V + + W+K ++ P
Sbjct: 8241 ----NIKERLIPPSFTKRLSETVE-ETE--GNSFKLEGRVAGSQPITVAWYKNNIEIQPT 8293
Query: 3444 HSVQDG------VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQA--LPSVLINIRT 3495
+ + VL+++ + G Y C+ G A ++ +VI+ P V T
Sbjct: 8294 SNCEITFKNNTLVLQVRKAGMNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLT 8353
Query: 3496 SVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG------IVQSGGVVRIAHVELAD 3549
V TV G V+ C G ++ W K G ++P V+ + V AD
Sbjct: 8354 PV-TVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKAD 8412
Query: 3550 AGQYRCTATNAAGTTQSHVLLLVQALPQI----------------SMPQEVRVPAGSAAV 3593
+G Y C A+N AG+ + + ++ P + S PQ +RV + A
Sbjct: 8413 SGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTAT 8472
Query: 3594 FPCIASGYPTPDISWSK-------LDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNR 3646
F G P P++ W+K G + + + L + D+G Y C A N
Sbjct: 8473 FIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNE 8532
Query: 3647 QGKVKAFAHLQVPER 3661
G++++ +LQV ER
Sbjct: 8533 HGEIESNVNLQVDER 8547
Score = 352 bits (902), Expect = 6e-96
Identities = 471/2106 (22%), Positives = 770/2106 (36%), Gaps = 277/2106 (13%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSE----LHFPSVQPSDAGV 1743
+ +G + L+C+VSG+ P W + D + + S + R + L S +D G
Sbjct: 3842 IVRGTNALLQCEVSGTGPFEISWFK-DKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGE 3900
Query: 1744 YICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYT 1803
Y C N A L+ E P T ++ + G + A S +
Sbjct: 3901 YECVVANEVGKCGCMATHLLKEPP------TFVKKVDDLIALGGQTVTLQAAVRGSEPIS 3954
Query: 1804 LVWTR-----LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQ 1858
+ W + +GK+ + +L I +VQ+S G Y C N L V+
Sbjct: 3955 VTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGSQTSVGELIVK 4014
Query: 1859 ASGTLSAPVVSIHPPQLT-VQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGI 1917
P I +L V G A + G+P +W G L A +
Sbjct: 4015 E------PAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKD-GRPLVASKKYRISF 4067
Query: 1918 ------LRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERT-QVHAG 1970
L+ + E D QY + G V P R
Sbjct: 4068 KNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDIAPFFTKPLRNVDSVVN 4127
Query: 1971 RTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA------TLLIPAITTADAGFYL 2024
T RL C+ AG ++W K+G + A S+R IA +L I + DAG +
Sbjct: 4128 GTCRLDCKIAGSLPMRVSWFKDGKEI---AASDRYRIAFVEGTASLEIIRVDMNDAGNFT 4184
Query: 2025 CVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTW 2084
C AT+ G+ + ++V PP + S V G + L GS + W
Sbjct: 4185 CRATNSVGSKDSSGALIV-----QEPPSFVTKPGSKDVLPGSAVCLKSTFQGSTPLTIRW 4239
Query: 2085 YR------RGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGT 2138
++ GGS + S L L V +DSG Y C+V N +G E S + V
Sbjct: 4240 FKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGGVECSANLFVKEP- 4298
Query: 2139 HSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLP--ARH 2196
+T ++EPS + +G L C V G ++TW + ++H
Sbjct: 4299 -----------ATFVEKLEPSQL-LKKGDATQLACKVTGTPPIKITWFANDREIKESSKH 4346
Query: 2197 QTH----GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESS 2252
+ ++LRL V DSGEY+C +G S +V ++ S P E
Sbjct: 4347 RMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIVIVKES------PYFTKEFK 4400
Query: 2253 SSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGS------RLYIFQASPADA 2306
V + + L VAG ++TW+K L + + + L I + ADA
Sbjct: 4401 PIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGRKYKTFIQDHLVSLQILKFVAADA 4460
Query: 2307 GQYVCRASNGMEASI-TVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVP 2365
G+Y CR +N + +SI + VT + + ST +R G T +
Sbjct: 4461 GEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTSSLR----------GGTAAFQATLK 4510
Query: 2366 GQSHAQVTWHKRGGSLP----VRHQTHGSLLRLYQAS--PADSGEYVCRVLGSSVPLEAS 2419
G VTW K + +R ++ LY + G+YVC+ + S
Sbjct: 4511 GSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGKYVCQAKNDAGIQRCS 4570
Query: 2420 VLVTI-EPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLP 2478
L+++ EPA T+ E+ S V +G L +G W K G L
Sbjct: 4571 ALLSVKEPA----------TITEEAVSIDVTQGDPATLQVKFSGTKEITAKWFKDGQELT 4620
Query: 2479 --ARHQVHG----SRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGV 2532
+++++ S L+++ DSGEY V G + + +
Sbjct: 4621 LGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLDLIIPP----- 4675
Query: 2533 AYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSR------LR 2586
++ +++ + G +DL C+VA P +I W+K + + + S L
Sbjct: 4676 SFTKKLKKMDS--IKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNTAFLE 4733
Query: 2587 IPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQT 2646
I Q+ DSG Y C +N AG + S H+ PP +E V T
Sbjct: 4734 ISQLEGTDSGTYTCSATNKAGHNQCS----------GHLTVKEPPYFVEKPQSQDVNPNT 4783
Query: 2647 -LDLNCVVARQPQAIITWYKRGGSLPSR------HQTHGSHLRLHQMSVADSGEYVCRAN 2699
+ L +V I W+K L S + L L DSG Y+C+ +
Sbjct: 4784 RVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGTYICQLS 4843
Query: 2700 NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVT 2759
N++ + + V P + +R G++ C + G +V+
Sbjct: 4844 NDVGTATSKATLFVKEPPQFIKKPSPVLVLR---------NGQSTTFECQITGTPKIRVS 4894
Query: 2760 WHKRGGSLPS---HHQTRGSRLRLHHVSPA---DSGEYVCRVMGSSGPLEASVLVTIEAS 2813
W+ G + + H + L +S A +SG YVC +G S+ + ++
Sbjct: 4895 WYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKE- 4953
Query: 2814 GSSAVHVPAPGGAPPIRI-EPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQ 2872
PP I E V + ++L+C V G +VTW K + + +
Sbjct: 4954 -------------PPTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKK 5000
Query: 2873 ------VHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQP 2926
V L + + P+D+GEY C V+ G+ S V ++ P
Sbjct: 5001 YTLTDRVSVFNLHITKCDPSDTGEYQCIVSNEGGSCSCSTRVALKEP------------P 5048
Query: 2927 IYIEASSSHVTE-GQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGS------QLRLH 2979
+I+ + T + V G +TW K L + S L++
Sbjct: 5049 SFIKKIENTTTVLKSSATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIR 5108
Query: 2980 LVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDA 3039
V SG Y C+A + G E+ +F + P++ I S V +
Sbjct: 5109 SVDNGHSGRYTCQAKNESGVERCYAFLLVQEPAQ----------IVEKAKSVDVTEKDPM 5158
Query: 3040 SFKCLIHDGAAPISLEWKTRNQELEDNVHISP----NGSIITIVGTRPSNHGTYRCVASN 3095
+ +C++ G + ++W +++ + + S N + I + G Y N
Sbjct: 5159 TLECVVA-GTPELKVKWLKDGKQIVPSRYFSMSFENNVASFRIQSVMKQDSGQYTFKVEN 5217
Query: 3096 AYGVAQSVVNLSV---HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISST 3152
+G + L V + PP+ + V +G ++ +EC +G SA+W +
Sbjct: 5218 DFGSSSCDAYLRVLDQNIPPSFTKKLTKMDKV-LGSSIHMECKVSGSLPISAQWFKDGKE 5276
Query: 3153 PAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAP 3212
+ + + L++++ + D Y C N G + V P
Sbjct: 5277 ISTSAKYRLVCHERSVSLEVNNLELEDTANYTCKVSNVAGDDACSGILTVKEPPSFLVKP 5336
Query: 3213 QVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSPLPWQHRLEGDT--LIIP 3266
Q + TVE + G+P I W K L S LEG T L +
Sbjct: 5337 GRQQAIPDSTVE------FKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFLNLY 5390
Query: 3267 RVAQQDSGQYICNATSPAGHAEATIILHVESPP-YATTVPEHASVQAGETVQLQCLAHGT 3325
V +GQY C+ T+ G T +L V PP + + V+AG++ +L+C G+
Sbjct: 5391 SVDASKTGQYTCHVTNDVGSDSCTTMLLVTEPPKFVKKLEASKIVKAGDSSRLECKIAGS 5450
Query: 3326 PPLTFQWSRVGSSLPGRATARNE------LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQ 3379
P + W R LP R ++ + EDSG + C N GS +
Sbjct: 5451 PEIRVVWFRNEHELPASDKYRMTFIDSVAVIQMNNLSTEDSGDFICEAQNPAGSTSCSTK 5510
Query: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
++V+ PP +S P P +ET A V C + ++ W+K+ Q
Sbjct: 5511 VIVKEPP---VFSSFP----------PIVETLK-NAEVSLECELSGTPPFEVVWYKDKRQ 5556
Query: 3440 LPPGHSVQDGV------LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINI 3493
L + + I N+D S G Y C+A G + ++ P + +
Sbjct: 5557 LRSSKKYKIASKNFHTSIHILNVDTSDIGEYHCKAQNEVGSDTCVCTVKLKEPPRFVSKL 5616
Query: 3494 RTSVQTVVVGHAVEFECLALGDPKPQVTWSKV-------GGHLRPGIVQSGGVVRIAHVE 3546
+ TVV G E + G V W K ++R V++ ++ A E
Sbjct: 5617 NSL--TVVAGEPAELQASIEGAQPIFVQWLKEKEEVIRESENIRITFVENVATLQFAKAE 5674
Query: 3547 LADAGQYRCTATNAAGTTQSHVLLLV-QALPQISMPQEVRVPAGSAAVFPCIASGYPTPD 3605
A+AG+Y C N G ++ L+V + + + V G C +G P
Sbjct: 5675 PANAGKYICQIKNDGGMRENMATLMVLEPAVIVEKAGPMTVTVGETCTLECKVAGTPELS 5734
Query: 3606 ISWSKLDGSLPPDSRLEN-------NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
+ W K DG L S+ + L + SV QDAGTY N GK A + V
Sbjct: 5735 VEWYK-DGKLLTSSQKHKFSFYNKISSLRILSVERQDAGTYTFQVQNNVGKSSCTAVVDV 5793
Query: 3659 PERVVP 3664
+R VP
Sbjct: 5794 SDRAVP 5799
Score = 330 bits (846), Expect = 2e-89
Identities = 433/1891 (22%), Positives = 689/1891 (36%), Gaps = 265/1891 (14%)
Query: 1939 AGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPP 1998
AG+ + L+V+ P+V + V +G+ R +G P I+W KE L
Sbjct: 3222 AGRNRSSVTLYVNAPEPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLST 3281
Query: 1999 QARSERTDIA---TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASP----- 2050
+ + TLL+ DA Y C A + G A + V SP
Sbjct: 3282 GFKCKFLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMP 3341
Query: 2051 --PPVKIESSSPSVT-EGQTLDLNCVVAGSAHAQVTWYRRGGSLPPH-----TQVHGS-R 2101
PP I +VT EGQ C V+G+ +V+WY + + P TQ + +
Sbjct: 3342 VYPPAIITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQ 3400
Query: 2102 LRLPQVSPADSGEYVCRVENGSGPKEASITV------SVLHGTHSGPSYTPVPGSTRPI- 2154
L + + P D G Y N G ++ + S+LH + P+
Sbjct: 3401 LEIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILH--ERIEQEIEMEMKAAPVI 3458
Query: 2155 --RIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL------PARHQTHGSLLRLH 2206
+IEP VA G C + + + W K G + R + S L +
Sbjct: 3459 KRKIEP--LEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEIL 3516
Query: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSS-TVAEGQTLDLS 2265
+ D GEY C G + + +T+ + PP + S T G+
Sbjct: 3517 RTQVVDCGEYTCKASNEYGSVSCTATLTVTEA-----YPPTFLSRPKSLTTFVGKAAKFI 3571
Query: 2266 CVVAGQAHAQVTWYKRGGSLPARHQVRGSR------LYIFQASPADAGQYVCRASNGMEA 2319
C V G + W K G +L R S L + + D G Y C+ASN A
Sbjct: 3572 CTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKFGA 3631
Query: 2320 SITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGG 2379
I A L +EP S + + + L C V VTW K G
Sbjct: 3632 DIC-------QAELIIIDKPHFIKELEPVQSAI--NKKVHLECQVDEDRKVTVTWSKDGQ 3682
Query: 2380 SLP------VRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPAL 2433
LP + + + L + A DSG YVC + S VT+ S
Sbjct: 3683 KLPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSF--- 3739
Query: 2434 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH------GSR 2487
V+ S + G++ L+C + G QVTW K L + V +
Sbjct: 3740 -----VKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAI 3794
Query: 2488 LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIES-SSASLA 2546
L + V DSG Y C V G+ S + I++ P I++ A +
Sbjct: 3795 LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEP-----------PSFIKTLEPADIV 3843
Query: 2547 NGHTLDLNCLVASQAPHTITWYKRGGSLPS--RHQIVGSR----LRIPQVTPADSGEYVC 2600
G L C V+ P I+W+K + S ++++ + L I AD GEY C
Sbjct: 3844 RGTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYEC 3903
Query: 2601 HVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAI 2660
V+N G G ++H+ P + + GQT+ L V
Sbjct: 3904 VVANEVGK---------CGCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPIS 3954
Query: 2661 ITWYK------RGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVS 2714
+TW K G + + L + + ++ G+Y C A N
Sbjct: 3955 VTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAEN-------------- 4000
Query: 2715 PSAGSPSAPGSSM---PIRI--ESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS 2769
AGS ++ G + P +I + V G+ L V G + W+K G L +
Sbjct: 4001 -EAGSQTSVGELIVKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVA 4059
Query: 2770 HHQTRGS------RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAP 2823
+ R S +L+ + DSG+Y + G T+ AP
Sbjct: 4060 SKKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTVLDRDI------AP 4113
Query: 2824 GGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQ-----VHGPL- 2877
P+R + V G T L C + G +V+W K G + A + V G
Sbjct: 4114 FFTKPLR---NVDSVVNG-TCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTAS 4169
Query: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEAS-VLVTIEPSSPGPIPAPGLAQPIYIEASSSHV 2936
L + +V D+G ++C+ T S G+ ++S L+ EP P + PG S V
Sbjct: 4170 LEIIRVDMNDAGNFTCRATNSVGSKDSSGALIVQEP--PSFVTKPG----------SKDV 4217
Query: 2937 TEGQTLDLNCVVPGQAHAQVTWYK------RGGSLPARHQTHGSQLRLHLVSPADSGEYV 2990
G + L G + W+K GGS + S L L+LV +DSG Y
Sbjct: 4218 LPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYT 4277
Query: 2991 CRAAS-GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGA 3049
C+ ++ G E A+ V P + + PS +++G C + G
Sbjct: 4278 CKVSNVAGGVECSANLFVKEP----------ATFVEKLEPSQLLKKGDATQLACKV-TGT 4326
Query: 3050 APISLEWKTRNQELEDN----VHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVN 3105
PI + W ++E++++ + + +++ + + G Y C A N G
Sbjct: 4327 PPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAG------- 4379
Query: 3106 LSVHGPPTVSVLPEGPVWVKVGKA--------VTLECVSAGEPRSSARWTRISSTPAKLE 3157
S H ++ ++ E P + K K V L AG P W + ++
Sbjct: 4380 -SDH-CSSIVIVKESPYFTKEFKPIEVLKEYDVMLLAEVAGTPPFEITWFKDNTILRSGR 4437
Query: 3158 QRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE 3217
+ + D LQI +DAG Y C N +G++ + + + P +
Sbjct: 4438 KYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSS-------ICSARVTLREPPSFIK 4490
Query: 3218 EAELTVE-AGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGD------TLIIPRVAQ 3270
+ E T G TA + + GS T+ W K + + +L + +
Sbjct: 4491 KIESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEV 4550
Query: 3271 QDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTF 3330
+ G+Y+C A + AG + +L V+ P T V G+ LQ GT +T
Sbjct: 4551 KHDGKYVCQAKNDAGIQRCSALLSVKEPATITEEAVSIDVTQGDPATLQVKFSGTKEITA 4610
Query: 3331 QWSR------VGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQG 3384
+W + +GS T +L +DSG Y V N VG + A++ V
Sbjct: 4611 KWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVLD 4670
Query: 3385 PPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGH 3444
IP T ++ ++ G+ ++ C V ++WFK+ ++
Sbjct: 4671 -------LIIPPSFTKKLKKMDSIK----GSFIDLECIVAGSHPISIQWFKDDQEISASE 4719
Query: 3445 SVQ------DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQ 3498
+ L I L+ + GTY C A G Q S L ++ P + + Q
Sbjct: 4720 KYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFV--EKPQSQ 4777
Query: 3499 TVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQS------GGVVRIAHVELADAGQ 3552
V V+ + L G + W K L G +S + + + D+G
Sbjct: 4778 DVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDSGT 4837
Query: 3553 YRCTATNAAGTTQSHVLLLVQALPQ-ISMPQEVRV-PAGSAAVFPCIASGYPTPDISWSK 3610
Y C +N GT S L V+ PQ I P V V G + F C +G P +SW
Sbjct: 4838 YICQLSNDVGTATSKATLFVKEPPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSW-Y 4896
Query: 3611 LDGSLPPDSRLEN-------NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVV 3663
LDG+ + + R +++GTYVC A N G L+V E
Sbjct: 4897 LDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKE--P 4954
Query: 3664 PYFTQTPYSFLPLPTIKDAYRKFEIKITFRP 3694
P F + P+ +K + + E ++T P
Sbjct: 4955 PTFIR---ELKPVEVVKYSDVELECEVTGTP 4982
Score = 320 bits (819), Expect = 3e-86
Identities = 474/2132 (22%), Positives = 767/2132 (35%), Gaps = 333/2132 (15%)
Query: 1698 CQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELH---FPSVQPSDAGVYICTCRNLHQS 1754
C+VS P W ++D + + + +H PS + SDAG Y
Sbjct: 3079 CEVS-EPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKYTVVAGG---- 3133
Query: 1755 NTSRAELLVT------EAPSKPITVTVEEQRS-------------QSVRPGADVTFICTA 1795
N S A+L V + K + V +E+QR+ + G ++ F
Sbjct: 3134 NVSTAKLFVEGRDVRIRSIKKEVQV-IEKQRAVVEFEVNEDDVDAHWYKDGIEINFQVQE 3192
Query: 1796 KSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATL 1855
+ K +V R+H + I + SDAG Y ++ + TL
Sbjct: 3193 RHKY----VVERRIHR-------------MFISETRQSDAGEYTFVAGR----NRSSVTL 3231
Query: 1856 HVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKA---- 1911
+V A P V +TVQ G+ A F +G P P + W QL +
Sbjct: 3232 YVNAP---EPPQVLQELQPVTVQSGKPARFCAVISGRPQPKISWY--KEEQLLSTGFKCK 3286
Query: 1912 QIHGG---ILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPER---- 1964
+H G L L P D A Y C A + G A L V P V VSP++
Sbjct: 3287 FLHDGQEYTLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVE---VPEV-VSPDQEMPV 3342
Query: 1965 -----------TQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIATL 2010
T G+ R CR +G ++W + + P T D L
Sbjct: 3343 YPPAIITPLQDTVTSEGQPARFQCRVSGT-DLKVSWYSKDKKIKPSRFFRMTQFEDTYQL 3401
Query: 2011 LIPAITTADAGFYLCVATSPAGTAQARIQVVV--------------LSASDASPPPVKIE 2056
I D G Y VA++ G + + + + + P +K +
Sbjct: 3402 EIAEAYPEDEGTYTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRK 3461
Query: 2057 SSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL------PPHTQVHGSRLRLPQVSPA 2110
V G C + + + + W++ G + + + S L + +
Sbjct: 3462 IEPLEVALGHLAKFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVV 3521
Query: 2111 DSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLD 2170
D GEY C+ N G + T++V +Y P P S G+
Sbjct: 3522 DCGEYTCKASNEYGSVSCTATLTVTE------AYPPT------FLSRPKSLTTFVGKAAK 3569
Query: 2171 LNCVVPGQAHAQVTWHKRGGSLPARHQTHGS------LLRLHQVTPADSGEYVCHVVGTS 2224
C V G + W K G +L S +L L +T D G Y C
Sbjct: 3570 FICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHILELSNLTIQDRGVYSCKASNKF 3629
Query: 2225 GPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS 2284
G + + E +I P +E S + + + L C V VTW K G
Sbjct: 3630 G----ADICQAELIIIDKPHFIKELEPVQSAI--NKKVHLECQVDEDRKVTVTWSKDGQK 3683
Query: 2285 LPAR------HQVRGSRLYIFQASPADAGQYVCRASN-GMEASITVTVTGTQGANLAYPA 2337
LP + + + L I A D+G YVC ASN +S + TVT + +
Sbjct: 3684 LPPGKDYKICFEDKIATLEIPLAKLKDSGTYVCTASNEAGSSSCSATVTVREPPSFVK-- 3741
Query: 2338 GSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTH------GSL 2391
+++PS + G++ L+C + G QVTW K L + ++
Sbjct: 3742 ------KVDPSYLML-PGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAI 3794
Query: 2392 LRLYQASPADSGEYVCRVLGSSVPLEASVLVTI-EPAGSVPALGVTPTVRIESSSSQVAE 2450
L + DSG Y C + S + I EP + L + +
Sbjct: 3795 LDITDVKVEDSGSYSCEAVNDVGSDSCSTEIVIKEPPSFIKTL----------EPADIVR 3844
Query: 2451 GQTLDLNCLVAGQAHAQVTWHKRGGSLPA--RHQVHGSR----LRLLQVTPADSGEYVCR 2504
G L C V+G +++W K + + ++++ + L + AD GEY C
Sbjct: 3845 GTNALLQCEVSGTGPFEISWFKDKKQIRSSKKYRLFSQKSLVCLEIFSFNSADVGEYECV 3904
Query: 2505 V---VGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQA 2561
V VG G +L + + +++ A G T+ L V
Sbjct: 3905 VANEVGKCGCMATHLL-----------KEPPTFVKKVDDLIA--LGGQTVTLQAAVRGSE 3951
Query: 2562 PHTITWYK------RGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIV 2615
P ++TW K G + + L IP V + G+Y C N AGS +TS+
Sbjct: 3952 PISVTWMKGQEVIREDGKIKMSFSNGVAVLIIPDVQISFGGKYTCLAENEAGS-QTSVGE 4010
Query: 2616 TIQGSGSSHVPSVSPPIRI--ESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS- 2672
I V P +I + V G L VA P+ WYK G L +
Sbjct: 4011 LI----------VKEPAKIIERAELIQVTAGDPATLEYTVAGTPELKPKWYKDGRPLVAS 4060
Query: 2673 -----RHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSM 2727
+ + + L+ + + DSG+Y +N + + +V AP +
Sbjct: 4061 KKYRISFKNNVAQLKFYSAELHDSGQYTFEISNEVGSSSCETTFTV---LDRDIAPFFTK 4117
Query: 2728 PIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR------GSRLRLH 2781
P+R S V G T L+C + G +V+W K G + + + R + L +
Sbjct: 4118 PLRNVDS---VVNG-TCRLDCKIAGSLPMRVSWFKDGKEIAASDRYRIAFVEGTASLEII 4173
Query: 2782 HVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEG 2841
V D+G + CR S G + ++SG+ V P P +P S V G
Sbjct: 4174 RVDMNDAGNFTCRATNSVG--------SKDSSGALIVQEP-----PSFVTKPGSKDVLPG 4220
Query: 2842 QTLDLKCVVPGQAHAQVTWHK------RGGNLPARHQVHGPLLRLNQVSPADSGEYSCQV 2895
+ LK G + W K GG+ + L L V +DSG Y+C+V
Sbjct: 4221 SAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKV 4280
Query: 2896 TGSSGTLEASV-LVTIEPSSPGPIPAPGLAQPIYIE--ASSSHVTEGQTLDLNCVVPGQA 2952
+ +G +E S L EP++ ++E S + +G L C V G
Sbjct: 4281 SNVAGGVECSANLFVKEPAT-------------FVEKLEPSQLLKKGDATQLACKVTGTP 4327
Query: 2953 HAQVTWYKRGGSL--PARHQ----THGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFT 3006
++TW+ + ++H+ + LRL V DSGEY+C A + G + +S
Sbjct: 4328 PIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMCEAQNEAGSDHCSSIV 4387
Query: 3007 VTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELED- 3065
+ SP + + V + D + G P + W N L
Sbjct: 4388 IV----------KESPYFTKEFKPIEVLKEYDVMLLAEV-AGTPPFEITWFKDNTILRSG 4436
Query: 3066 ---NVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPV 3122
I + + I+ ++ G Y+C +N G + +++ PP+ E
Sbjct: 4437 RKYKTFIQDHLVSLQILKFVAADAGEYQCRVTNEVGSSICSARVTLREPPSFIKKIESTS 4496
Query: 3123 WVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGT 3182
++ G A + G + W + S + + ++ A L +S + G
Sbjct: 4497 SLRGGTA-AFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKHDGK 4555
Query: 3183 YVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT 3242
YVC A+N G + + V A + E + V G ATL+ +G+ T
Sbjct: 4556 YVCQAKNDAGIQRCSALLSVKEPA------TITEEAVSIDVTQGDPATLQVKFSGTKEIT 4609
Query: 3243 IHWSKLRSPLPWQHRLE---GDTLIIPRV---AQQDSGQYICNATSPAGHAEATI---IL 3293
W K L + + DT+ I ++ ++DSG+Y + G + +L
Sbjct: 4610 AKWFKDGQELTLGSKYKISVTDTVSILKIISTEKKDSGEYTFEVQNDVGRSSCKARINVL 4669
Query: 3294 HVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATAR------N 3347
+ PP T + G + L+C+ G+ P++ QW + + +
Sbjct: 4670 DLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASEKYKFSFHDNT 4729
Query: 3348 ELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQ 3407
L + DSG Y C TNK G + L V+ PP + PQ
Sbjct: 4730 AFLEISQLEGTDSGTYTCSATNKAGHNQCSGHLTVKEPPYFVE--------------KPQ 4775
Query: 3408 LETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG--HSV----QDGVLRIQNLDQSCQ 3461
+ + V+ V ++WFK+ +L G SV L + +
Sbjct: 4776 SQDVNPNTRVQLKALVGGTAPMTIKWFKDNKELHSGAARSVWKDDTSTSLELFAAKATDS 4835
Query: 3462 GTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVT 3521
GTYICQ G A + A L ++ P I + V + G + FEC G PK +V+
Sbjct: 4836 GTYICQLSNDVGTATSKATLFVKE-PPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVS 4894
Query: 3522 WSKVGGHL----RPGIVQSGGVV--RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL 3575
W G + + GI G+ +I+ + ++G Y C A N AGT + L V+
Sbjct: 4895 WYLDGNEITAIQKHGISFIDGLATFQISGARVENSGTYVCEARNDAGTASCSIELKVKEP 4954
Query: 3576 PQ-ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPD------SRLENNMLML 3628
P I + V V S C +G P +++W K + + R+ L +
Sbjct: 4955 PTFIRELKPVEVVKYSDVELECEVTGTPPFEVTWLKNNREIRSSKKYTLTDRVSVFNLHI 5014
Query: 3629 PSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE 3660
P D G Y C +N G + + E
Sbjct: 5015 TKCDPSDTGEYQCIVSNEGGSCSCSTRVALKE 5046
Score = 314 bits (805), Expect = 1e-84
Identities = 467/2159 (21%), Positives = 765/2159 (35%), Gaps = 316/2159 (14%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSRED---GRPVPSGTQQRHQGSELHFPSVQPSDAGVY 1744
V G L +G+PP W +++ + + + L D Y
Sbjct: 6938 VETGSPIVLEATYTGTPPISVSWIKDEYLISQSERCSITMTEKSTILEILESTIEDYAQY 6997
Query: 1745 ICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTL 1804
C N + A + V E P +E G T C +P +
Sbjct: 6998 SCLIENEAGQDICEALVSVLEPP-----YFIEPLEHVEAVIGEPATLQCKVDG-TPEIRI 7051
Query: 1805 VWTRLHNG--KLPTRAMDFNG---ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA 1859
W + H P M F L I V SD G Y C N +A L ++A
Sbjct: 7052 SWYKEHTKLRSAPAYKMQFKNNVASLVINKVDHSDVGEYSCKADNSVGAVASSAVLVIKA 7111
Query: 1860 SGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILR 1919
P + + G F C GS + W G L A + +
Sbjct: 7112 RKL--PPFFARKLKDVHETLGFPVAFECRINGSEPLQVSWYKD-GVLLKDDANLQTSFVH 7168
Query: 1920 LPA---VEPTDQA---QYLCRAHSSAG--QQVARAVLHVHGGGGPRVQVSPERTQVHAGR 1971
A + TDQ+ QY C A + G A+ +L H P + P + G
Sbjct: 7169 NVATLQILQTDQSHIGQYNCSASNPLGTASSSAKLILSEHEVP-PFFDLKPVSVDLALGE 7227
Query: 1972 TVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIATLLIPAITTADAGFYLCVAT 2028
+ C G ITW K+ + P + T + ATL + + DAG Y C A+
Sbjct: 7228 SGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDAGQYTCYAS 7287
Query: 2029 SPAGTAQARIQVVVLSASDASPPPVKIESSSPS--VTEGQTLDLNCVVAGSAHAQVTWYR 2086
+ AG Q+ V PP I+ PS V + + C + GS +V WY+
Sbjct: 7288 NIAGKDSCSAQLGV------QEPPRFIKKLEPSRIVKQDEFTRYECKIGGSPEIKVLWYK 7341
Query: 2087 RGGSLPPHTQVHGSR------LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHS 2140
+ ++ S L + +S DSG+Y C N +G +S ++ V
Sbjct: 7342 DETEIQESSKFRMSFVDSVAVLEMHNLSVEDSGDYTCEAHNAAGSASSSTSLKVKE---- 7397
Query: 2141 GPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA----RH 2196
P+ R +P +G + L C + G V+W+K L + +
Sbjct: 7398 ----PPI------FRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKI 7447
Query: 2197 QTHGSLLRLH--QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPP--VRIESS 2252
+ L +H V AD GEY C G + ++A PP V+ S
Sbjct: 7448 MSENFLTSIHILNVDAADIGEYQCKATNDVGSDTCVGSIALKA-------PPRFVKKLSD 7500
Query: 2253 SSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR-------HQVRGSRLYIFQASPAD 2305
STV G+ + L + G V W+K G + + + L + PA+
Sbjct: 7501 ISTVV-GKEVQLQTTIEGAEPISVVWFKDKGEIVRESDNIWISYSENIATLQFSRVEPAN 7559
Query: 2306 AGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVP 2365
AG+Y C+ N G Q I +P S +V G T L C V
Sbjct: 7560 AGKYTCQIKND---------AGMQECFATLSVLEPATIVEKPESIKVTTGDTCTLECTVA 7610
Query: 2366 GQSHAQVTWHKRGGSLPVRHQTHGSL------LRLYQASPADSGEYVCRVLGSSVPLEAS 2419
G W K G L ++ S L++ +P+DSG Y V +
Sbjct: 7611 GTPELSTKWFKDGKELTSDNKYKISFFNKVSGLKIINVAPSDSGVYSFEVQNPVGKDSCT 7670
Query: 2420 VLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPA 2479
+ + V P+ + + G ++ + C V G V+W G + +
Sbjct: 7671 ASLQVSDRT------VPPSFTRKLKETNGLSGSSVVMECKVYGSPPISVSWFHEGNEISS 7724
Query: 2480 RHQVHGS------RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVA 2533
+ + L + + +DSG+Y C +G+ E S +T+++ S
Sbjct: 7725 GRKYQTTLTDNTCALTVNMLEESDSGDYTCIATNMAGSDECSAPLTVREPPSFVQ----- 7779
Query: 2534 YPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL-PSRHQIVG-----SRLRI 2587
+ + G + +V P +++W+K L P V + L +
Sbjct: 7780 -----KPDPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELEL 7834
Query: 2588 PQVTPADSGEYVCHVSNGAG--SRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQ 2645
V + SGEY C VSN AG S T L + + S IE P ++EG
Sbjct: 7835 FDVDTSQSGEYTCIVSNEAGKASCTTHLYIKAPAKFVKRLNDYS----IEKGKPLILEG- 7889
Query: 2646 TLDLNCVVARQPQAIITWYKRGGSLPSRHQTH------GSHLRLHQMSVADSGEYVCRAN 2699
P +TW K G ++ + + + L + +V D+G+Y C
Sbjct: 7890 ------TFTGTPPISVTWKKNGINVTPSQRCNITTTEKSAILEIPSSTVEDAGQYNCYIE 7943
Query: 2700 N--NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQ 2757
N D+ A I+I P P V+ G++ L C + G
Sbjct: 7944 NASGKDSCSAQILILEPPYFVKQLEPVK------------VSVGDSASLQCQLAGTPEIG 7991
Query: 2758 VTWHKRGGSL------PSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
V+W+K L H + + L + V DSGEY+C+ S G + AS +T++
Sbjct: 7992 VSWYKGDTKLRPTTTYKMHFRNNVATLVFNQVDINDSGEYICKAENSVGEVSASTFLTVQ 8051
Query: 2812 ASGSSAVHVPAPGGAPPIRIEPSSSRVAE------GQTLDLKCVVPGQAHAQVTWHKRGG 2865
++ PS SR G + C + G V+W+K G
Sbjct: 8052 EQ----------------KLPPSFSRQLRDVQETVGLPVVFDCAISGSEPISVSWYKDGK 8095
Query: 2866 NLPARHQVHGPLL------RLNQVSPADSGEYSCQVTGSSGTLEASV-LVTIEPSSPGPI 2918
L V L + + + +G+YSC T G+ +S L+ E +P
Sbjct: 8096 PLKDSPNVQTSFLDNTATLNIFKTDRSLAGQYSCTATNPIGSASSSARLILTEGKNP--- 8152
Query: 2919 PAPGLAQPIY-IEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK------RGGSLPARHQT 2971
P + I + G++ D C V G +V+W K GG +
Sbjct: 8153 -------PFFDIRLAPVDAVVGESADFECHVTGTQPIKVSWAKDSREIRSGGKYQISYLE 8205
Query: 2972 HGSQLRLHLVSPADSGEYVCRAASGPGPEQ-EASFTVT---VPPSEGSSYRLRSPVISID 3027
+ + L + V DSG+Y C A + G + A + +PPS + RL
Sbjct: 8206 NSAHLTVLKVDKGDSGQYTCYAVNEVGKDSCTAQLNIKERLIPPS--FTKRL-------- 8255
Query: 3028 PPSSTVQQGQDASFKCLIH-DGAAPISLEWKTRNQELEDN----VHISPNGSIITIVGTR 3082
S TV++ + SFK G+ PI++ W N E++ + N ++ +
Sbjct: 8256 --SETVEETEGNSFKLEGRVAGSQPITVAWYKNNIEIQPTSNCEITFKNNTLVLQVRKAG 8313
Query: 3083 PSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG--PVWVKVGKAVTLECVSAGEP 3140
++ G Y C SN G A ++ + P V + PV V G+ V L C G
Sbjct: 8314 MNDAGLYTCKVSNDAGSALCTSSIVIKEPKKPPVFDQHLTPVTVSEGEYVQLSCHVQGSE 8373
Query: 3141 RSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT-AQKQVE 3199
+W + ++ ++ AVL++ +D+G YVC A N G+ K
Sbjct: 8374 PIRIQWLKAGREIKPSDRCSFSFASGTAVLELRDVAKADSGDYVCKASNVAGSDTTKSKV 8433
Query: 3200 VIVDTGAMAPGAPQVQ--------AEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSP 3251
I D A+AP + +E + V TAT G P P + W+K +
Sbjct: 8434 TIKDKPAVAPATKKAAVDGRLFFVSEPQSIRVVEKTTATFIAKVGGDPIPNVKWTKGK-- 8491
Query: 3252 LPWQHRLEGDTLIIPR-----------VAQQDSGQYICNATSPAGHAEATIILHVESPP- 3299
W+ +G + I + + DSG Y C A + G E+ + L V+
Sbjct: 8492 --WRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSGLYRCVAFNEHGEIESNVNLQVDERKK 8549
Query: 3300 ------------YATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARN 3347
T + + + + E ++ L + P +++R + G R
Sbjct: 8550 QEKIEGDLRAMLKKTPILKKGAGEEEEIDIMELLKNVDPKEYEKYAR----MYGITDFRG 8605
Query: 3348 ELLHFE---RAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQV 3404
L FE ++ E++ R + E + LV L T P ++
Sbjct: 8606 LLQAFELLKQSQEEETHRLEIEEIERSERDEKEFEELVSFIQQRLSQTE-PVTLIKDIEN 8664
Query: 3405 TPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ---DG---VLRIQNLDQ 3458
L+ ++ P +L W+K +L P + DG LR++N
Sbjct: 8665 QTVLKDNDAVFEIDIKINYPE---IKLSWYKGTEKLEPSDKFEISIDGDRHTLRVKNCQL 8721
Query: 3459 SCQGTY--ICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDP 3516
QG Y +C H A A ++ A L ++ T+ G C P
Sbjct: 8722 KDQGNYRLVCGPH----IASAKLTVIEPAWERHLQDV-----TLKEGQTCTMTC-QFSVP 8771
Query: 3517 KPQVTWSKVGGHLRP------GIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLL 3570
+ W + G L+P + + IA V D GQY C + T + + +
Sbjct: 8772 NVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAEDQGQYTCKYEDL--ETSAELRI 8829
Query: 3571 LVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL------ENN 3624
+ + Q + V +A F C S + ++W K L + +
Sbjct: 8830 EAEPIQFTKRIQNIVVSEHQSATFECEVS-FDDAIVTWYKGPTELTESQKYNFRNDGRCH 8888
Query: 3625 MLMLPSVRPQDAGTY-VCTATNRQGKVKAFAHLQVPERVVPYFTQ---TPYSFLPLPTI 3679
+ + +V P D G Y V +G+ ++ A L + + + + P S +P+PT+
Sbjct: 8889 YMTIHNVTPDDEGVYSVIARLEPRGEARSTAELYLTTKEIKLELKPPDIPDSRVPIPTM 8947
Score = 107 bits (268), Expect = 2e-22
Identities = 228/1103 (20%), Positives = 390/1103 (35%), Gaps = 204/1103 (18%)
Query: 2343 IRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGS------LLRLYQ 2396
I + S +V GQ V + A+V W+ G L + H + L +
Sbjct: 32376 ITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHNGVELQESSKIHYTNTSGVLTLEILD 32435
Query: 2397 ASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDL 2456
DSG Y R + ++ EAS T++ G G T + +V +L
Sbjct: 32436 CHTDDSGTY--RAVCTNYKGEASDYATLDVTG-----GDYTTYASQRRDEEVPRSVFPEL 32488
Query: 2457 NCLVAGQAHAQVTWHKRGGSLPA-------RHQVHGSRLRLLQVTPADSGEYVCRVVGSS 2509
+A+A V+ K+ + A + Q+ +R L + S E +
Sbjct: 32489 T---RTEAYA-VSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEK 32544
Query: 2510 GTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYK 2569
+E S I+ L+ + + S ++ G + +C + T+TW +
Sbjct: 32545 SLEEKSTTRKIKTTLAAR--------ILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLR 32596
Query: 2570 RGG--SLPSRHQIVGSRLR----IPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 2623
+G S +RHQ+ ++ + I V +D G Y V N G +E +TIQ + +
Sbjct: 32597 KGQVLSTSARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVT 32656
Query: 2624 HVPSVSPPIRIES-----SSPTVVEG---------------------------------- 2644
SPP R++S SP V+
Sbjct: 32657 EKAVTSPP-RVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVS 32715
Query: 2645 ---------------QTLDLNCVVARQPQAI--ITWYKRGGSLPSR--HQTHGS-----H 2680
+ L CVV +TWYK G L Q H S
Sbjct: 32716 APPKITQFLKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYE 32775
Query: 2681 LRLHQMSVADSGEYVCR-------ANNNIDAL-------------------------EAS 2708
L+++ ++ +D GEYVC + N+ + E++
Sbjct: 32776 LKINNLTESDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTEST 32835
Query: 2709 IVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCV-VPGQAHAQVTWHK----- 2762
+ P A P SS P+ + +++ V G+ W K
Sbjct: 32836 VTRKTEPKAPEPI---SSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAI 32892
Query: 2763 -RGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVP 2821
+GG G L +H +DSG Y C V S+G + +S +TI+A +
Sbjct: 32893 TQGGKYKLSEDKGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQ-- 32950
Query: 2822 APGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLN 2881
+ S+ + +E T K VV + + + A+ Q +L
Sbjct: 32951 ----------KVSTQKTSE-ITPQKKAVVQEEISQKALRSEEIKMSEAKSQE-----KLA 32994
Query: 2882 QVSPADSGEYSCQVTGSSGT-LEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ 2940
A S +V S+ T LE S++ + I ++ + EGQ
Sbjct: 32995 LKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQ 33054
Query: 2941 TLDLNCVVPGQAHAQVTWYKRGGSLPA----RHQTHGSQ--LRLHLVSPADSGEYVCRAA 2994
L L + G V W G L R+ GS L + S D G C +
Sbjct: 33055 RLVLKANIAGAT--DVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISK 33112
Query: 2995 SGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISL 3054
+ G + + +T+ S +P P S + +GQ+ F C I +P +
Sbjct: 33113 TKEGIVK-CQYDLTL-----SKELSDAPAFISQPRSQNINEGQNVLFTCEISGEPSP-EI 33165
Query: 3055 EWKTRNQ--ELEDNVHISPNGSI--ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHG 3110
EW N + NV IS + ++ + I S+ G Y A N G + +L V
Sbjct: 33166 EWFKNNLPISISSNVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLP 33225
Query: 3111 ---PPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSH 3167
P+ V+ + + + + V + A ++ SS+ A T S
Sbjct: 33226 LVEEPSREVVLRTSGDTSLQGSFSSQSVQMSASKQEASFSSFSSSSAS--SMTEMKFASM 33283
Query: 3168 AVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGA-----PQVQAEEAELT 3222
+ +SS + S +V ++ ++ ++ T M P+++A ++++
Sbjct: 33284 SAQSMSSMQES----FVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDIS 33339
Query: 3223 VEAGHTATLRCSATGSPAPTIHWS----KLRSPLPWQHRLEG----DTLIIPRVAQQDSG 3274
++ G T+ C+ TG P P + WS K+ S + +E TLII V +QD G
Sbjct: 33340 IDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGG 33399
Query: 3275 QYICNATSPAGHAEATIILHVES 3297
Y + + G AT+ +H+ S
Sbjct: 33400 LYTLSLGNEFGSDSATVNIHIRS 33422
Score = 107 bits (266), Expect = 3e-22
Identities = 186/943 (19%), Positives = 328/943 (34%), Gaps = 192/943 (20%)
Query: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP--ARHQV----HGPLLR 2879
A I +P S V EG++ C G+ VTW ++G L ARHQV +
Sbjct: 32560 AARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFE 32619
Query: 2880 LNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPS-------------------------- 2913
++ V +D G YS V S G EA +TI+ +
Sbjct: 32620 ISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVKSPEAV 32679
Query: 2914 -SPGPIPAPGLAQPIYIEASSSHVTEGQTLD------------------------LNCVV 2948
SP + +P + P + + + T + + L CVV
Sbjct: 32680 KSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAKLTCVV 32739
Query: 2949 PGQA--HAQVTWYKRGGSLP--ARHQTHGS-----QLRLHLVSPADSGEYVCRAASGPGP 2999
+VTWYK G L Q H S +L+++ ++ +D GEYVC + G
Sbjct: 32740 ESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEISGEGGT 32799
Query: 3000 EQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTR 3059
S T Q +FK IH+ + IS K+
Sbjct: 32800 ------------------------------SKTNLQFMGQAFKS-IHEKVSKISETKKSD 32828
Query: 3060 NQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE 3119
+ E V + ++P + ++ VA+ V + PT
Sbjct: 32829 QKTTESTVTRKTEPKAPEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTA----- 32883
Query: 3120 GPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSD 3179
+W K GKA+T KL + G L+I SD
Sbjct: 32884 --IWTKDGKAIT------------------QGGKYKLSEDKGGFF-----LEIHKTDTSD 32918
Query: 3180 AGTYVCLAQNALGTAQKQ----VEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSA 3235
+G Y C +N+ G+ ++ I DT A + +E+T + S
Sbjct: 32919 SGLYTCTVKNSAGSVSSSCKLTIKAIKDTEAQKVSTQKT----SEITPQKKAVVQEEISQ 32974
Query: 3236 TGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSG-----QYICNATSPAGHAEAT 3290
+ I S+ +S + E ++I ++ + + + A
Sbjct: 32975 KALRSEEIKMSEAKSQEKLALKEEASKVLISEEVKKSAATSLEKSIVHEEITKTSQASEE 33034
Query: 3291 IILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATAR---- 3346
+ H E ++T + S+ G+ + L+ G + +W G L R
Sbjct: 33035 VRTHAEIKAFSTQM----SINEGQRLVLKANIAGATDV--KWVLNGVELTNSEEYRYGVS 33088
Query: 3347 --NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQV 3404
++ L ++A+ D G C K G + L + S P
Sbjct: 33089 GSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTL----------SKELSDAPAFIS 33138
Query: 3405 TPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDG------VLRIQNLDQ 3458
P+ + + G +V F C + + ++ WFK + +V L I+N
Sbjct: 33139 QPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASV 33198
Query: 3459 SCQGTYICQAHGPWGKAQASAQLVIQAL---PSVLINIRTSVQTVVVGHAVEFECLALGD 3515
S G Y +A G+ A+A L++ L PS + +RTS T + G + + + +
Sbjct: 33199 SDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQG-SFSSQSVQMSA 33257
Query: 3516 PKPQVTWSKVGGHLRPGIV---------QSGGVVRIAHVELADAGQYRCT-ATNAAGTTQ 3565
K + ++S + QS ++ + VE++ + + T +T
Sbjct: 33258 SKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLESSTS 33317
Query: 3566 SHVLLLVQALPQI--SMPQEVRVPAGSAAVFPCIASGYPTPDISWS----KLDGSLPPDS 3619
+ ++ +P ++P ++ + G C +G PTP+++WS K+
Sbjct: 33318 KMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRF 33377
Query: 3620 RLEN----NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
+EN L++ V+ QD G Y + N G A ++ +
Sbjct: 33378 HIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHI 33420
Score = 103 bits (256), Expect = 5e-21
Identities = 391/1908 (20%), Positives = 646/1908 (33%), Gaps = 339/1908 (17%)
Query: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE-RTD-IATLLIP 2013
P + + PE +V G T R CR G P + W G + R R D I L I
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIV 1900
Query: 2014 AITTADAGFYLCVATSPAGTAQARIQVVVLSASD-------ASPPPVKIESSSPSVTEGQ 2066
+ D G A +P G + ++++ + D A P + P + +
Sbjct: 1901 DCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEFHVHEPGKLQFE 1960
Query: 2067 TLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV--HGSRLRLPQVSPADSGEY--VCRVENG 2122
++ V + +V +R + H +V LR + G Y + VE
Sbjct: 1961 VQKVDRPVDTTETKEVVKLKRAERIT-HEKVPEESEELRSKFKRRTEEGYYEAITAVELK 2019
Query: 2123 SGPKEASITV-------SVLHGTH----------------SGPSYTPVPGSTRPIRIEPS 2159
S K+ S +LH T + P++ P P P
Sbjct: 2020 SRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKITIPTFKPDKIELSPSMEAPK 2079
Query: 2160 ------SSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSL-------LRLH 2206
S V +G V G+ + W+K G + + + L +
Sbjct: 2080 IFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIR 2139
Query: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC 2266
VT DS + + +G + + ++A + E E T+
Sbjct: 2140 DVTAEDSASIMVKAINIAGETSSHAFLLVQAK----QLITFTQELQDVVAKEKDTMATFE 2195
Query: 2267 VVAGQAHAQVTWYKRGGSLPA--RHQVRGSR----LYIFQASPADAGQYVCRASNGMEAS 2320
+ +V WYK G + ++++ R L I +DA Y C
Sbjct: 2196 CETSEPFVKVKWYKDGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDENVK 2255
Query: 2321 ITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWH----- 2375
T + +GA + + E +V E + +L C+V ++ +H
Sbjct: 2256 TTAKLI-VEGAVVEFVK--------ELQDIEVPESYSGELECIVSPENIEGKWYHNDVEL 2306
Query: 2376 KRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGV 2435
K G + + L + + D GEY + G + + ++P G+
Sbjct: 2307 KSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDGKKTTCK----LKMKPRPIAILQGL 2362
Query: 2436 TPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH------GSRLR 2489
S +V EG + L V+ ++ + W K G + +VH L
Sbjct: 2363 --------SDQKVCEGDIVQLEVKVSLES-VEGVWMKDGQEVQPSDRVHIVIDKQSHMLL 2413
Query: 2490 LLQVTPADSGEYVCRV--VGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLAN 2547
+ +T D+G Y + +G S + SV +S V P++ ++
Sbjct: 2414 IEDMTKEDAGNYSFTIPALGLSTSGRVSV-----------YSVDVITPLK----DVNVIE 2458
Query: 2548 GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVG------SRLRIPQVTPADSGEYVCH 2601
G L C V+ ++ WY + ++ RL I + +D G Y
Sbjct: 2459 GTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPYKLI 2518
Query: 2602 VSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESS--SPTVVEGQTLDLNCVVARQPQA 2659
V G ET+ ++++ I+I T E Q + ++
Sbjct: 2519 V----GRVETNCNLSVE------------KIKIIRGLRDLTCTETQNVVFEVELSHSGID 2562
Query: 2660 IITWYKRGGSLPSRHQTHGSHLRLHQMSVA-----DSGEYVCRANNNIDALEASIVISVS 2714
++ +K PS +H ++++++V D G+Y A N+ + + ++
Sbjct: 2563 VLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKYTFYAGENMTSGKLTV----- 2617
Query: 2715 PSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR 2774
+ G+ S P + VAE + C V ++ W + G LP + R
Sbjct: 2618 -AGGAISKP---------LTDQTVAESQEAVFECEV-ANPDSKGEWLRDGKHLPLTNNIR 2666
Query: 2775 GS------RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPP 2828
RL + D GEY +V S + S + +EA
Sbjct: 2667 SESDGHKRRLIIAATKLDDIGEYTYKVATS----KTSAKLKVEA---------------- 2706
Query: 2829 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT---WHKRGGNLPARHQ----VHGPL--LR 2879
++I+ + + +T D V H V W K G L + + V G + LR
Sbjct: 2707 VKIKKTLKNLTVTETQDAVFTVE-LTHPNVKGVQWIKNGVVLESNEKYAISVKGTIYSLR 2765
Query: 2880 LNQVSPADSGEYSCQV--TGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
+ + D Y ++ G+S L + I+ P + A A + E S SH T
Sbjct: 2766 IKNCAIVDESVYGFRLGRLGASARLHVETVKIIK--KPKDVTALENAT-VAFEVSVSHDT 2822
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSL-PARHQTHGSQLRLHL-----VSPADSGEYVC 2991
VP V W+ + + P+ S+ ++H +SP+D+GEY
Sbjct: 2823 ----------VP------VKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEYT- 2865
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
A G + F T+ + + +I+ P + + ASF+C + P
Sbjct: 2866 -AVVGQLECKAKLFVETL--------HITKTMKNIEVPET-----KTASFECEVSHFNVP 2911
Query: 3052 ISLEWKTRNQELE--DNVHISPNGSI--ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLS 3107
W E+E + I G + + I+ T + Y V N Q L+
Sbjct: 2912 SM--WLKNGVEIEMSEKFKIVVQGKLHQLIIMNTSTEDSAEYTFVCGND----QVSATLT 2965
Query: 3108 VHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR----ISSTPAKLEQRTYGL 3163
V S+L + + + +T E V+ S +W + I ST K + RT L
Sbjct: 2966 VTPIMITSMLKD--INAEEKDTITFE-VTVNYEGISYKWLKNGVEIKSTD-KCQMRTKKL 3021
Query: 3164 MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV 3223
S L I + DA Y +A A TA VE + + ++ V
Sbjct: 3022 THS---LNIRNVHFGDAADYTFVAGKATSTATLYVEA---------RHIEFRKHIKDIKV 3069
Query: 3224 EAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDT------LIIPRVAQQDSGQYI 3277
A C + P T+ W K L R++ L+IP D+G+Y
Sbjct: 3070 LEKKRAMFECEVS-EPDITVQWMKDDQELQITDRIKIQKEKYVHRLLIPSTRMSDAGKY- 3127
Query: 3278 CNATSPAGHAEATIILHVESPPYAT-TVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVG 3336
T AG +T L VE ++ + V + ++ + + W + G
Sbjct: 3128 ---TVVAGGNVSTAKLFVEGRDVRIRSIKKEVQVIEKQRAVVEFEVN-EDDVDAHWYKDG 3183
Query: 3337 SSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPA 3396
+ + R++ + ER R ++ ++A V G S + A
Sbjct: 3184 IEINFQVQERHKYV-VER-------RIHRMFISETRQSDAGEYTFVAGRNRSSVTLYVNA 3235
Query: 3397 GSTPTVQVTPQLETKSIGASVEFHCAVPSDRGT-QLRWFKEGGQLPPG------HSVQDG 3449
P V Q T G F CAV S R ++ W+KE L G H Q+
Sbjct: 3236 PEPPQVLQELQPVTVQSGKPARF-CAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEY 3294
Query: 3450 VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI---------QALPSVLINIRTSVQTV 3500
L + Y C+A +G A SA L + Q +P I T +Q
Sbjct: 3295 TLLLIEAFPEDAAVYTCEAKNDYGVATTSASLSVEVPEVVSPDQEMPVYPPAIITPLQDT 3354
Query: 3501 VV--GHAVEFECLALGDPKPQVTWSKVGGHLRPGIV------QSGGVVRIAHVELADAGQ 3552
V G F+C G +V+W ++P + + IA D G
Sbjct: 3355 VTSEGQPARFQCRVSGTDL-KVSWYSKDKKIKPSRFFRMTQFEDTYQLEIAEAYPEDEGT 3413
Query: 3553 YRCTATNAAGTTQSHVLLLVQALPQI---SMPQEVR-----------------VPAGSAA 3592
Y A+NA G S L ++A I + QE+ V G A
Sbjct: 3414 YTFVASNAVGQVSSTANLSLEAPESILHERIEQEIEMEMKAAPVIKRKIEPLEVALGHLA 3473
Query: 3593 VFPCIASGYPTPDISWSKLDGSLPPDS----RLENNMLMLPSVRPQ--DAGTYVCTATNR 3646
F C P W K + R + L +R Q D G Y C A+N
Sbjct: 3474 KFTCEIQSAPNVRFQWFKAGREIYESDKCSIRSSKYISSLEILRTQVVDCGEYTCKASNE 3533
Query: 3647 QGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRP 3694
G V A L V E P F P S L T KF +T P
Sbjct: 3534 YGSVSCTATLTVTEAYPPTFLSRPKS---LTTFVGKAAKFICTVTGTP 3578
Score = 102 bits (253), Expect = 1e-20
Identities = 211/1020 (20%), Positives = 347/1020 (34%), Gaps = 149/1020 (14%)
Query: 1779 RSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNG-----KLPTRAMDFNGILTIR--NVQ 1831
RS V G + FI +SK P + W HNG + +G+LT+ +
Sbjct: 32381 RSHRVPCGQNTRFILNVQSK-PTAEVKW--YHNGVELQESSKIHYTNTSGVLTLEILDCH 32437
Query: 1832 LSDAGTY--VCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSA 1889
D+GTY VCT A D T + T ++ P+ +V P +L A
Sbjct: 32438 TDDSGTYRAVCTNYKGEASDYATLDVTGGDYTTYASQRRDEEVPR-SVFP-ELTRTEAYA 32495
Query: 1890 TGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLH 1949
S T E + K+Q+ L + E + A+ A +
Sbjct: 32496 VSSFKKTSEMEASSSVR-EVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEKSTTRK 32554
Query: 1950 VHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDI-- 2007
+ R+ P V+ G + R C G P T+TW ++G L AR + T
Sbjct: 32555 IKTTLAARILTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKY 32614
Query: 2008 -ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSA-----SDASPPPVKIE----- 2056
+T I ++ +D G Y V + G +A + + A + SPP VK
Sbjct: 32615 KSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVK 32674
Query: 2057 ----------------------------------------SSSPSVTE-------GQTLD 2069
S+ P +T+ +
Sbjct: 32675 SPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQFLKAEASKEIAK 32734
Query: 2070 LNCVVAGSA--HAQVTWYRRGGSLPP--HTQVHGS-----RLRLPQVSPADSGEYVCRVE 2120
L CVV S +VTWY+ G L H Q H S L++ ++ +D GEYVC +
Sbjct: 32735 LTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTESDQGEYVCEIS 32794
Query: 2121 NGSGPKEASIT------------VSVLHGTHSGPSYTP---VPGSTRPIRIEPSSSH--- 2162
G + ++ VS + T T V T P EP SS
Sbjct: 32795 GEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPKAPEPISSKPVI 32854
Query: 2163 --------VAEGQTLDLNCVVPGQAHAQVTWHK------RGGSLPARHQTHGSLLRLHQV 2208
V+ G+ W K +GG G L +H+
Sbjct: 32855 VTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLEIHKT 32914
Query: 2209 TPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVV 2268
+DSG Y C V ++G + +S +TI+A I + S+ T VV
Sbjct: 32915 DTSDSGLYTCTVKNSAGSVSSSCKLTIKA------IKDTEAQKVSTQKTSEITPQKKAVV 32968
Query: 2269 AGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCR-ASNGMEASITVTVTG 2327
+ + + A+ Q + + +AS + V + A+ +E SI V
Sbjct: 32969 QEEISQKALRSEEIKMSEAKSQEKLALKE--EASKVLISEEVKKSAATSLEKSI-VHEEI 33025
Query: 2328 TQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG----GSLPV 2383
T+ + + + I+ + + EGQ L L + G + V W G S
Sbjct: 33026 TKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGAT--DVKWVLNGVELTNSEEY 33083
Query: 2384 RHQTHGS--LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRI 2441
R+ GS L + QAS D G C ++ +T+ L P
Sbjct: 33084 RYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLTLS-----KELSDAPAFIS 33138
Query: 2442 ESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSR------LRLLQVTP 2495
+ S + EGQ + C ++G+ ++ W K + V SR L + +
Sbjct: 33139 QPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLEIRNASV 33198
Query: 2496 ADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNC 2555
+DSG+Y + G A+ + + + + V S SL +
Sbjct: 33199 SDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLR----TSGDTSLQGSFSSQSVQ 33254
Query: 2556 LVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIV 2615
+ AS+ + + + + S + +S + S S T L
Sbjct: 33255 MSASKQEASFSSFSSSSASSMTEMKFASMSAQSMSSMQESFVEMSSSSFMGISNMTQLES 33314
Query: 2616 TIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQ 2675
+ + + + P I S ++ EG+ L + C +P +TW G + S+ Q
Sbjct: 33315 STSKMLKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQ 33374
Score = 94.0 bits (232), Expect = 3e-18
Identities = 228/1095 (20%), Positives = 382/1095 (34%), Gaps = 192/1095 (17%)
Query: 1865 APVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH----GGILRL 1920
AP +++ V GQ F + PT ++W G +L ++IH G+L L
Sbjct: 32373 APRITLRMRSHRVPCGQNTRFILNVQSKPTAEVKWYHN-GVELQESSKIHYTNTSGVLTL 32431
Query: 1921 PAVE--PTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTV---RL 1975
++ D Y + G+ A L V GG + +R R+V
Sbjct: 32432 EILDCHTDDSGTYRAVCTNYKGEASDYATLDVTGGD--YTTYASQRRDEEVPRSVFPELT 32489
Query: 1976 YCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQ 2035
A V S T E S + +S+ T+ L +A A + +
Sbjct: 32490 RTEAYAVSSFKKTSEMEASSSVREVKSQMTETRESLSSYEHSASAEMKSAALEEKSLEEK 32549
Query: 2036 ARIQVV--VLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPP 2093
+ + + L+A + P S +V EG++ +C G VTW R+G L
Sbjct: 32550 STTRKIKTTLAARILTKP------RSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLST 32603
Query: 2094 H------TQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYT-- 2145
T + S + V +D G Y VEN G +EA T+++ + + T
Sbjct: 32604 SARHQVTTTKYKSTFEISSVQASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSP 32663
Query: 2146 -----PVPGSTRPIRIE-------PSSSH------------------------------- 2162
P P P ++ P SH
Sbjct: 32664 PRVKSPEPRVKSPEAVKSPKRVKSPEPSHPKAVSPTETKPTPTEKVQHLPVSAPPKITQF 32723
Query: 2163 ---VAEGQTLDLNCVVPGQA--HAQVTWHKRGGSLP--ARHQTHGSL-----LRLHQVTP 2210
A + L CVV +VTW+K G L Q H S L+++ +T
Sbjct: 32724 LKAEASKEIAKLTCVVESSVLRAKEVTWYKDGKKLKENGHFQFHYSADGTYELKINNLTE 32783
Query: 2211 ADSGEYVCHVVGTSGPLEASVLV------------------------TIEASV------- 2239
+D GEYVC + G G + ++ T E++V
Sbjct: 32784 SDQGEYVCEISGEGGTSKTNLQFMGQAFKSIHEKVSKISETKKSDQKTTESTVTRKTEPK 32843
Query: 2240 IPGPI---PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK------RGGSLPARHQ 2290
P PI P + +TV+ + G+ W K +GG
Sbjct: 32844 APEPISSKPVIVTGLQDTTVSSDSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSED 32903
Query: 2291 VRGSRLYIFQASPADAGQYVCRASN---GMEASITVTVTGTQGANLAYPAGSTQPIRIEP 2347
G L I + +D+G Y C N + +S +T+ + A + + I P
Sbjct: 32904 KGGFFLEIHKTDTSDSGLYTCTVKNSAGSVSSSCKLTIKAIKDTE-AQKVSTQKTSEITP 32962
Query: 2348 SSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVC 2407
V + +++ +++ K L ++ +AS E V
Sbjct: 32963 QKKAVVQE---EISQKALRSEEIKMSEAKSQEKLALKE----------EASKVLISEEVK 33009
Query: 2408 RVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVA--EGQTLDLNCLVAGQAH 2465
+ +S LE S++ S + V I++ S+Q++ EGQ L L +AG
Sbjct: 33010 KSAATS--LEKSIVHEEITKTSQASEEVRTHAEIKAFSTQMSINEGQRLVLKANIAGA-- 33065
Query: 2466 AQVTWHKRG----GSLPARHQVHGS--RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVT 2519
V W G S R+ V GS L + Q + D G C G + +T
Sbjct: 33066 TDVKWVLNGVELTNSEEYRYGVSGSDQTLTIKQASHRDEGILTCISKTKEGIVKCQYDLT 33125
Query: 2520 IQQRLSGSHSQGVAYPVRI-ESSSASLANGHTLDLNCLVASQAPHTITWYKRG--GSLPS 2576
+ + LS + P I + S ++ G + C ++ + I W+K S+ S
Sbjct: 33126 LSKELSDA-------PAFISQPRSQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISS 33178
Query: 2577 RHQIVGSR----LRIPQVTPADSGEYVCHVSN--GAGSRETSLIVTIQGSGSSHVPSVSP 2630
I SR L I + +DSG+Y N G S SL+V +P V
Sbjct: 33179 NVSISRSRNVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMV---------LPLVEE 33229
Query: 2631 PIR---IESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMS 2687
P R + +S T ++G + ++ Q + S + T + S
Sbjct: 33230 PSREVVLRTSGDTSLQGSFSSQSVQMSASKQE--ASFSSFSSSSASSMTEMKFASMSAQS 33287
Query: 2688 VADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA--EGETLD 2745
++ E +++ +++ S ++ A +P +IE+ S ++ EG+ L
Sbjct: 33288 MSSMQESFVEMSSSSFMGISNMTQLESSTSKMLKAGIRGIPPKIEALPSDISIDEGKVLT 33347
Query: 2746 LNCVVPGQAHAQVTWHKRGGSLPSHHQTRG--------SRLRLHHVSPADSGEYVCRVMG 2797
+ C G+ +VTW G + S Q R + L + V D G Y +
Sbjct: 33348 VACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGN 33407
Query: 2798 SSGPLEASVLVTIEA 2812
G A+V + I +
Sbjct: 33408 EFGSDSATVNIHIRS 33422
Score = 88.2 bits (217), Expect = 2e-16
Identities = 251/1358 (18%), Positives = 472/1358 (34%), Gaps = 226/1358 (16%)
Query: 2163 VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH----QTHGSLLRLHQVTPADSGEYVC 2218
+ G +L L V G+ +TW K+G L +R SLL + +V D+G+Y
Sbjct: 29458 IRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTI 29517
Query: 2219 HVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTW 2278
SG A+VLV + + PGP P V+++ S + +TW
Sbjct: 29518 EAENQSGKKSATVLVKVYDT--PGPCPSVKVKEVS-----------------RDSVTITW 29558
Query: 2279 Y--KRGGSLPARHQV---RGSRLYIFQASPADAGQYVCRASNGMEASITV-TVTGTQGAN 2332
G P + + R + + F+ + + R S +E ++ V
Sbjct: 29559 EIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKCSKTLYRISGLVEGTMYYFRVLPENIYG 29618
Query: 2333 LAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR---GGSLPVRHQTHG 2389
+ P ++ + + A+ + +D+ +S + W K GGS +
Sbjct: 29619 IGEPCETSDAVLVSEVPLVPAKLEVVDVT-----KSTVTLAWEKPLYDGGSRLTGYVLEA 29673
Query: 2390 ----------------SLLRLYQASPADSGEYVCRVL-----GSSVPLEASVLVTIEPAG 2428
++L S + +Y+ R+ G S P E VT++
Sbjct: 29674 CKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLR 29733
Query: 2429 SVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQV----- 2483
+P + ++ + + V G+ ++L +AG+ +W G L +V
Sbjct: 29734 VLPTIDLST---MPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETH 29790
Query: 2484 -HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSS 2542
++L + + T D+GEY + +GT ++ V I + P++I+
Sbjct: 29791 TKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTG-----PIKIDEID 29845
Query: 2543 AS----------LANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTP 2592
A+ L G L +V + H R G LP + S + ++T
Sbjct: 29846 ATSITISWEPPELDGGAPLS-GYVVEQRDAH------RPGWLPVSESVTRSTFKFTRLT- 29897
Query: 2593 ADSGEYVCHVSN----GAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLD 2648
+ EYV V+ G GS S ++ + S IRI T+ Q D
Sbjct: 29898 -EGNEYVFRVAATNRFGIGSYLQSEVIECRSS-----------IRIPGPPETL---QIFD 29942
Query: 2649 LNCVVARQPQAIITWYKR---GGSLPSRHQTHGSHLRLHQMSVADSGEYVC---RANNNI 2702
++ + +TWY GGS + + +R + + R+
Sbjct: 29943 VS-----RDGMTLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLT 29997
Query: 2703 DALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTW-- 2760
+ LE ++ + GS S PI + G+ + + + W
Sbjct: 29998 EGLEYEHRVTAINARGSGKPSRPSKPI--VAMDPIAPPGKPQNPRVTDTTRTSVSLAWSV 30055
Query: 2761 -HKRGGSLPSHHQTRGSRLRLH-----HVSPADSGEYVCRVMGSSGPLEASVLVTIEASG 2814
GGS + + ++ H + +P EY + VL
Sbjct: 30056 PEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQGAEYRFRVLACNAGGP 30115
Query: 2815 SSAVHVPAPGGAPPIRIEPSSSR---------VAEGQTLDLKCVVPGQAHAQVTWHKRGG 2865
VP + P V +G + L + G+ W K G
Sbjct: 30116 GEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLTIPIKGKPFPICKWTKEGQ 30175
Query: 2866 NLPARHQV-----HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTI--EPSSP-GP 2917
++ R + H L+ + + DSG Y + G + V + P+SP GP
Sbjct: 30176 DISKRAMIATSETHTELV-IKEADRGDSGTYDLVLENKCGKKAVYIKVRVIGSPNSPEGP 30234
Query: 2918 IPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK-----RGGSLPARHQTH 2972
+ + + +G L ++ + + WY RG SL +
Sbjct: 30235 LEYDDIQVRSVRVSWRPPADDGGADILGYILERREVPKAAWYTIDSRVRGTSLVVK---- 30290
Query: 2973 GSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS- 3031
++ EY R ++ E F ++ P ++P+ +PPS+
Sbjct: 30291 ---------GLKENVEYHFRVSA------ENQFGISKPLKSEEPVTPKTPLNPPEPPSNP 30335
Query: 3032 -----TVQQGQDASFKCLIHDGAAPISLEWKTRNQELED----NVHISPNGSIITIVGTR 3082
+ S+ DG + ++ + R + D + ++ T+ G
Sbjct: 30336 PEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQITTTMYTVTGLV 30395
Query: 3083 PSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRS 3142
P +R +A N G++++ P + V+ + P + K + LE +S +
Sbjct: 30396 PDAEYQFRIIAQNDVGLSET-------SPASEPVVCKDP-FDKPSQPGELEILSISKDSV 30447
Query: 3143 SARWTRISSTPAK------LEQRTYG-----------LMDSHAVLQISSAKPSDAGTYVC 3185
+ +W + K +E R G + D I + +
Sbjct: 30448 TLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSNKERIKDKQ--FTIGGLLEATEYEFRV 30505
Query: 3186 LAQNALGTAQ-KQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIH 3244
A+N G ++ ++ + + T + AP ++ E ++T + G A L C G P P I
Sbjct: 30506 FAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIK 30565
Query: 3245 WSKLRSPL--PWQHRLEGD----TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESP 3298
W + L ++++ D TL + Q+D G Y C AT+ G E + L +++
Sbjct: 30566 WYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQAT 30625
Query: 3299 PY---ATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNE-LLHFER 3354
P + E G T++L + G P W L E H+
Sbjct: 30626 PQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTH 30685
Query: 3355 AAPED------SGRYRCRVTNKVGSAEAFAQLLVQGPP 3386
++ +G+Y+ +++N G+ +A + +Q P
Sbjct: 30686 LVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDKP 30723
Score = 82.8 bits (203), Expect = 7e-15
Identities = 315/1667 (18%), Positives = 556/1667 (33%), Gaps = 342/1667 (20%)
Query: 2236 EASVIPGPI-----PPVRIESSSS-TVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR- 2288
E + +P P+ PP + + TV EG+++ L C ++G VTWY+ + +
Sbjct: 928 ETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSI 987
Query: 2289 -----HQVRGSRLYIFQASPADAGQYVCRASNG--------------------------- 2316
Q +RL I +A D+G++ C A N
Sbjct: 988 DFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTE 1047
Query: 2317 ---------MEASITVTVTGTQGANLAYPAGSTQPIRI-EPSSSQVAEGQTLDLNCVVPG 2366
+E+ V + A P P I +P ++ EG ++ C V G
Sbjct: 1048 KFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGG 1107
Query: 2367 QSHAQVTWHKRGGSLPVRH--------QTHGSLLRLYQASPADSGEYVCRVLGSSVPLEA 2418
V W K G L + QT L + D+GEY V A
Sbjct: 1108 NPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSA 1167
Query: 2419 SV---------LVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVT 2469
S L+ + VT V+ E + A G + A +
Sbjct: 1168 SASLLEEADYELLMKSQQEMLYQTQVTAFVQ-EPKVGETAPGFVYSEYEKEYEKEQALIR 1226
Query: 2470 WHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHS 2529
++ R V + E R++ + T E + +++++ S
Sbjct: 1227 KKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKT--TLEELLEEDGEEKMAVDIS 1284
Query: 2530 QGVAYPVRIES--SSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP--SRHQIV---- 2581
+ A +S + + G + +C ++ I WYK G + R+Q+
Sbjct: 1285 ESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQD 1344
Query: 2582 -GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS----SHVPSVSPPIRIES 2636
+ LRIP V P D G Y SN G+ S + ++ + +++P++ P RI S
Sbjct: 1345 GRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRS 1404
Query: 2637 SSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVC 2696
SP V + ++ AR A + S R+ ++
Sbjct: 1405 LSPRSVSRSPIRMS--PARMSPARM-----------------SPARMSPARMSPGRRLEE 1445
Query: 2697 RANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHA 2756
+ ++ L + + ++ S EG+T + V G+
Sbjct: 1446 TDESQLERLYKPVFV-------------------LKPVSFKCLEGQTARFDLKVVGRPMP 1486
Query: 2757 QVTWHKRGGSLPSHHQTR-------GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVT 2809
+ W G + + + + L + +P+DSGE+ +G SV++T
Sbjct: 1487 ETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILT 1546
Query: 2810 IEASGSSAVHVPAPGGAPPIRIEP-SSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL- 2867
+EA P+ +E + + EG L++K G + + W K +
Sbjct: 1547 VEA---------VEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIV 1597
Query: 2868 PARH---QVHG----PLLRLNQVSPADSGEYSCQVTGSSG--TLEASVLVTIEPSSPGP- 2917
P ++ ++ G L+++ DS Y+ +G T V V +E + P P
Sbjct: 1598 PHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVEVEFAEPEPE 1657
Query: 2918 --------------IPAPGLAQPIYIEASSSHVTEGQTLD---------------LNCVV 2948
I AP L +P+++ EG D L
Sbjct: 1658 RKLIIPRGTYRAKEIAAPEL-EPLHLRYGQEQWEEGDLYDKEKQQKPFFKKKLTSLRLKR 1716
Query: 2949 PGQAHAQ------------VTWYKRGGSLPARHQTH------GSQLRLHLVSPADSGEYV 2990
G AH + V W G L A ++ L + DSG
Sbjct: 1717 FGPAHFECRLTPIGDPTMVVEWLHDGKPLEAANRLRMINEFGYCSLDYGVAYSRDSGIIT 1776
Query: 2991 CRAASGPGPEQEASFTVT-----------VPPSEGSSYRL-------------------- 3019
CRA + G + ++ + +P R+
Sbjct: 1777 CRATNKYGTDHTSATLIVKDEKSLVEESQLPEGRKGLQRIEELERMAHEGALTGVTTDQK 1836
Query: 3020 --RSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELE---------DNVH 3068
+ P I + P V +G+ A F+C + P + W Q + D +H
Sbjct: 1837 EKQKPDIVLYPEPVRVLEGETARFRCRVTGYPQP-KVNWYLNGQLIRKSKRFRVRYDGIH 1895
Query: 3069 ISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV--------------HGPPTV 3114
+ IV + + G + A N GV + V L + P
Sbjct: 1896 ------YLDIVDCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEF 1949
Query: 3115 SVLPEGPVWVKVGK----AVTLECVSAGEPRSSARWT------RISSTPAKLEQRT-YGL 3163
V G + +V K T E + + + R T +K ++RT G
Sbjct: 1950 HVHEPGKLQFEVQKVDRPVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRRTEEGY 2009
Query: 3164 MDSHAVLQISSAKPSDA------GTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE 3217
++ +++ S K ++ T L +++ + + + G + P + +
Sbjct: 2010 YEAITAVELKSRKKDESYEELLRKTKDELLHWTKELTEEEKKALAEEGKIT--IPTFKPD 2067
Query: 3218 EAEL----------------TVEAGHTATLRCSATGSPAPTIHWSK-----LRSPLPWQH 3256
+ EL TV G A R G P P W K RS + +
Sbjct: 2068 KIELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWY 2127
Query: 3257 RLEGDT--LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGE 3314
E + L+I V +DS + A + AG + L V++ T E V A E
Sbjct: 2128 WPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKE 2187
Query: 3315 TVQLQCLAHGT--PPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVG 3372
+ T P + +W + G + R +H +R + +T
Sbjct: 2188 KDTMATFECETSEPFVKVKWYKDGMEVHEGDKYR---MHSDRKV-----HFLSILTIDTS 2239
Query: 3373 SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASV--EFHCAVPSDRGTQ 3430
AE ++ +LV+ A I G+ V+ +L+ + S E C V S +
Sbjct: 2240 DAEDYSCVLVEDENVKTTAKLIVEGA--VVEFVKELQDIEVPESYSGELECIV-SPENIE 2296
Query: 3431 LRWF------KEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQ 3484
+W+ K G+ L ++++ + QG Y G + + +L ++
Sbjct: 2297 GKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDG----KKTTCKLKMK 2352
Query: 3485 ALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG------IVQSGG 3538
P ++ S Q V G V+ E + + + W K G ++P I +
Sbjct: 2353 PRPIAILQ-GLSDQKVCEGDIVQLE-VKVSLESVEGVWMKDGQEVQPSDRVHIVIDKQSH 2410
Query: 3539 VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIA 3598
++ I + DAG Y T +T V V ++ I+ ++V V G+ AV C
Sbjct: 2411 MLLIEDMTKEDAGNYSFTIPALGLSTSGRV--SVYSVDVITPLKDVNVIEGTKAVLECKV 2468
Query: 3599 SGYPTPDISWSKLDGSLPPDSRLE------NNMLMLPSVRPQDAGTY 3639
S + W D + PD R++ L++ D G Y
Sbjct: 2469 SVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINRTHASDEGPY 2515
Score = 81.3 bits (199), Expect = 2e-14
Identities = 283/1406 (20%), Positives = 492/1406 (34%), Gaps = 230/1406 (16%)
Query: 2435 VTPTVRIESSSSQVAE----------GQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH 2484
+ P RIE ++A+ G +L L V+G+ +TW K+G L +R +
Sbjct: 29435 IEPVERIEIPDLELADDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIID 29494
Query: 2485 G----SRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIES 2540
S L + +V D+G+Y SG + A+VLV + + G V+++
Sbjct: 29495 TTESYSLLIVDKVNRYDAGKYTIEAENQSGKKSATVLVKVYD------TPGPCPSVKVKE 29548
Query: 2541 SSASLANGHTLDLNCLVASQAPHTITWY--KRGGSLPSRHQIVGSR---LRIPQVTPADS 2595
S TITW G P + IV R +R +
Sbjct: 29549 VSRDSV-----------------TITWEIPTIDGGAPVNNYIVEKREAAMRAFKTVTTKC 29591
Query: 2596 GEYVCHVSN---GAGSRETSLIVTIQGSGS----------SHVPSVSPPIRI-ESSSPTV 2641
+ + +S G L I G G S VP V + + + + TV
Sbjct: 29592 SKTLYRISGLVEGTMYYFRVLPENIYGIGEPCETSDAVLVSEVPLVPAKLEVVDVTKSTV 29651
Query: 2642 VEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGE---YVCRA 2698
L +R ++ K G + T + H ++ + GE + RA
Sbjct: 29652 TLAWEKPLYDGGSRLTGYVLEACKAGTERWMKVVTLKPTVLEHTVTSLNEGEQYLFRIRA 29711
Query: 2699 NNN---IDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH 2755
N + E ++V P+ S+MP + HV G ++L + G+
Sbjct: 29712 QNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMP----QKTIHVPAGRPVELVIPIAGRPP 29767
Query: 2756 AQVTWHKRGGSLPSHHQ------TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVT 2809
+W G L + T+ ++L + + D+GEY + +G ++ V
Sbjct: 29768 PAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVI 29827
Query: 2810 IEASGSSAVHVPAPGGAPPIRIEPSSSRVA-EGQTLDLKCVVPGQAHAQVTWHKRGGNLP 2868
I P G I+ +S ++ E LD + G Q H R G LP
Sbjct: 29828 ILDKPG-----PPTGPIKIDEIDATSITISWEPPELDGGAPLSGYVVEQRDAH-RPGWLP 29881
Query: 2869 ARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIY 2928
V + +++ + + T G IE S IP P I+
Sbjct: 29882 VSESVTRSTFKFTRLTEGNEYVFRVAATNRFGIGSYLQSEVIECRSSIRIPGPPETLQIF 29941
Query: 2929 IEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKR---GGS-----LPARHQTHGSQ-LRLH 2979
+ +G TL TWY GGS + R + + +R++
Sbjct: 29942 DVSR-----DGMTL--------------TWYPPEDDGGSQVTGYIVERKEVRADRWVRVN 29982
Query: 2980 LVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDP----------- 3028
V P Y + G E E T G R P++++DP
Sbjct: 29983 KV-PVTMTRYRSTGLT-EGLEYEHRVTAINARGSGKPSRPSKPIVAMDPIAPPGKPQNPR 30040
Query: 3029 PSSTVQQGQDASFKCLIHDGAAPIS---LEWKTRNQELEDNVHISPNG-SIITIVGTRPS 3084
+ T + ++ +G + ++ +E + +Q + +P T+
Sbjct: 30041 VTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIREYTLTHLPQG 30100
Query: 3085 NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP-----------VWVKVGKAVTLE 3133
+R +A NA G + V G V+ + E P ++V+ G + L
Sbjct: 30101 AEYRFRVLACNAGGPGEPA---EVPGTVKVTEMLEYPDYELDERYQEGIFVRQGGVIRLT 30157
Query: 3134 CVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT 3193
G+P +WT+ +K + ++H L I A D+GTY + +N G
Sbjct: 30158 IPIKGKPFPICKWTKEGQDISK--RAMIATSETHTELVIKEADRGDSGTYDLVLENKCGK 30215
Query: 3194 AQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLP 3253
++V V +P +P+ E ++ V + + R A A + + R +P
Sbjct: 30216 KAVYIKVRV---IGSPNSPEGPLEYDDIQVRSVRVSW-RPPADDGGADILGYILERREVP 30271
Query: 3254 ---W---QHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEH 3307
W R+ G +L++ + + + +A + G ++ +P PE
Sbjct: 30272 KAAWYTIDSRVRGTSLVVKGLKENVEYHFRVSAENQFGISKPLKSEEPVTPKTPLNPPEP 30331
Query: 3308 ASVQAGETVQLQCLAHGTPPLTFQWSRV----GSSLPGRATARNE--------------- 3348
S + L ++ WSR GS + G R E
Sbjct: 30332 PSNPP------EVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWVRHNKTQIT 30385
Query: 3349 --LLHFERAAPEDSGRYRCRVTNKVGSAE---AFAQLLVQGP------PGSLPATSIPAG 3397
+ P+ ++R N VG +E A ++ + P PG L SI
Sbjct: 30386 TTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDKPSQPGELEILSISKD 30445
Query: 3398 STPTVQVTPQLE--TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQN 3455
S P+ + + +G VE+ + S W K + ++D I
Sbjct: 30446 SVTLQWEKPECDGGKEILGYWVEYRQSGDS------AWKKSNKE-----RIKDKQFTIGG 30494
Query: 3456 LDQSCQGTYICQAHGPWG--KAQASAQLVIQALPS-VLINIRTSVQTVV--VGHAVEFEC 3510
L ++ + + A G + + +A + L S IR ++ V +G A + C
Sbjct: 30495 LLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDVTTKLGEAAQLSC 30554
Query: 3511 LALGDPKPQVTWSKVGGHL---RPGIVQSGG---VVRIAHVELADAGQYRCTATNAAGTT 3564
+G P P + W + G L R + S G + + E D G Y C ATN G
Sbjct: 30555 QIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGVYTCIATNEVGEV 30614
Query: 3565 QSHVLLLVQALPQI----SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR 3620
++ LL+QA PQ + ++ GS + G P P ++W L
Sbjct: 30615 ETSSKLLLQATPQFHPGYPLKEKYYGAVGSTLRLHVMYIGRPVPAMTWFHGQKLLQNSEN 30674
Query: 3621 --LEN-----NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSF 3673
+EN +++M R AG Y +N G V A +++ ++ P
Sbjct: 30675 ITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEIQDK-----PDKPTG- 30728
Query: 3674 LPLPTIKDAYRKFEIKITFRPDSADG 3699
P + +A K I+++P + DG
Sbjct: 30729 ---PIVIEALLKNSAVISWKPPADDG 30751
Score = 80.9 bits (198), Expect = 3e-14
Identities = 247/1213 (20%), Positives = 428/1213 (35%), Gaps = 203/1213 (16%)
Query: 2562 PHTITWYKRGGSLPS--RHQIVG----SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIV 2615
P T+TW K +L S R+ I S L IPQVT D+G+Y+ + NG G ++S +
Sbjct: 27300 PPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYILTIENGVGEPKSSTVS 27359
Query: 2616 -----TIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSL 2670
T V VS P +++G + +N V+ ++ TW S+
Sbjct: 27360 VKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEKRDATKRTW-----SV 27414
Query: 2671 PSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIR 2730
S H+ + +L +S + A N I E +A P AP + ++
Sbjct: 27415 VS-HKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVKAAEVP-APIRDLSMK 27472
Query: 2731 IESSSSHVA-------EGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHV 2783
+ +S + +G ++ VV + + TW G S + +L
Sbjct: 27473 DSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSHAGISKTCEIEVS----QLKEQ 27528
Query: 2784 SPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVP-APGGAPPIRIEPSSSRVAEGQ 2842
S + + G S P+ + E + V + PG +RI G
Sbjct: 27529 SVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSDIPGAQVTVRI---------GH 27579
Query: 2843 TLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGP------LLRLNQVSPADSGEYSCQVT 2896
+ L+ G+ ++W K G L V L + G+Y+ V
Sbjct: 27580 NVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNAKKEHGGKYT--VI 27637
Query: 2897 GSSGTLEASVLVTI----EPSSP-GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQ 2951
+ +V +T+ PS P GPI + I + G ++ C +
Sbjct: 27638 LDNAVCRIAVPITVITLGPPSKPKGPIRFDEIKADSVILSWDVPEDNGGG-EITCYSIEK 27696
Query: 2952 AHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPP 3011
T +K S AR +LV A+ ++ RA + G Q ++ V
Sbjct: 27697 RETSQTNWKMVCSSVARTTFKVP----NLVKDAEY-QFRVRAENRYGVSQPLVSSIIV-- 27749
Query: 3012 SEGSSYRLRSPVISIDPPSSTV-----QQGQDASFKCLIHDGAAPIS---LEWKTRNQEL 3063
+ ++ R P PP V G ++ ++DG + ++ +E K RN L
Sbjct: 27750 ---AKHQFRIP----GPPGKPVIYNVTSDGMSLTWDAPVYDGGSEVTGFHVEKKERNSIL 27802
Query: 3064 EDNVHISP-NGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPV 3122
V+ SP +G G +R A N+ G++ S T++V P P
Sbjct: 27803 WQKVNTSPISGREYRATGLVEGLDYQFRVYAENSAGLSSP----SDPSKFTLAVSPVDPP 27858
Query: 3123 WVKVGKAVTLECV------------------SAGEPRSSARWTRISSTPAKLEQRTYGLM 3164
VT E + S + + + RW R + T Q T
Sbjct: 27859 GTPDYIDVTRETITLKWNPPLRDGGSKIVGYSIEKRQGNERWVRCNFTDVSECQYT---- 27914
Query: 3165 DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVE---VIVDTGAMAPGAPQVQAEEAE- 3220
++ P D + +A+NA+GT + +I+ P + E +
Sbjct: 27915 -------VTGLSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVPPIVEFGPEYFDG 27967
Query: 3221 LTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE-----GDTLIIPRVAQQD-SG 3274
L +++G + ++ G P P + W K + + +E G T + R A +D G
Sbjct: 27968 LIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRG 28027
Query: 3275 QYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQL---QCLAHGTPPLT-- 3329
Y A + +G A+A I + V+ P P + GE + L L G P+T
Sbjct: 28028 VYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIRFTNITGEKMTLWWDAPLNDGCAPITHY 28087
Query: 3330 ---------FQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAE----- 3375
W+ + ++ +L++ + ++R NK G
Sbjct: 28088 IIEKRETSRLAWALIEDKCEAQSYTAIKLIN------GNEYQFRVSAVNKFGVGRPLDSD 28141
Query: 3376 ---AFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLR 3432
A Q V PG ++I S P+ S G S + R
Sbjct: 28142 PVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPE----SDGGSEIQQYILERREKKSTR 28197
Query: 3433 WFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASA--------QLVIQ 3484
W K + P + + ++ L + + + A G AS + V
Sbjct: 28198 WVKVISKRP----ISETRFKVTGLTEGNEYEFHVMAENAAGVGPASGISRLIKCREPVNP 28253
Query: 3485 ALPSVLINIRTSVQTVV---------------VGHAVEFECLALGDPKPQVTWSKVGGHL 3529
P ++ + + +T V +G+ +E LGD W KV
Sbjct: 28254 PGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEMCKADLGD------WHKVNAE- 28306
Query: 3530 RPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQS-HVLLLVQALPQISMPQ------ 3582
V++ + ++ + ++R +A N AG S V ++A+ +++ P+
Sbjct: 28307 --ACVKTR--YTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRLTAPELDIDAN 28362
Query: 3583 --EVRVPAGSAAVFPCIA-SGYPTPDISWSKLDGSLPPDSRLEN----NMLMLPSVRPQD 3635
+ V A++ IA G PTP WSK D +L + + + L + + D
Sbjct: 28363 FKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRND 28422
Query: 3636 AGTYVCTATNRQG 3648
AG Y T N G
Sbjct: 28423 AGKYTLTVENNSG 28435
Score = 79.0 bits (193), Expect = 1e-13
Identities = 70/219 (31%), Positives = 96/219 (43%), Gaps = 23/219 (10%)
Query: 3207 MAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK-----LRSPLPWQHRLEGD 3261
M AP + V G TAT +G P P + W + S LP D
Sbjct: 1 MTTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 3262 ---TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVES---PPYATTVPEHASVQAGET 3315
L IP V + +SG+Y AT+ +G A +T L V++ PP + +V+ G
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQ 120
Query: 3316 VQLQCLAHGTPPLTFQWSRVG----SSLPGRATARNEL--LHFERAAPEDSGRYRCRVTN 3369
V+LQ G P ++ R G SSL + + +L L A PEDSG Y TN
Sbjct: 121 VRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATN 180
Query: 3370 KVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQL 3408
VG A + A+LLVQG +PA T T+ T Q+
Sbjct: 181 SVGRATSTAELLVQG------EEEVPAKKTKTIVSTAQI 213
Score = 77.0 bits (188), Expect = 4e-13
Identities = 186/855 (21%), Positives = 299/855 (34%), Gaps = 125/855 (14%)
Query: 2806 VLVTIEASGSSAVHVPAPG------GAPPIRIEPSSSR---VAEGQTLDLKCVVPGQAHA 2856
VL A S HVP P P + ++ + +R + G TL L ++ G
Sbjct: 17189 VLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFP 17248
Query: 2857 QVTWHKRGGNLPARHQVH----GPLLRLNQVSPADSGEYSCQVTGSSG--TLEASVLVTI 2910
+VTW K + P + ++ G L + + D G YS V +G T+ VLV
Sbjct: 17249 KVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLD 17308
Query: 2911 EPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLP---- 2966
+P P + + + + +G ++ N VV + A W +
Sbjct: 17309 KPGPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSH 17368
Query: 2967 -ARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3025
A+H G+Q +L A +Y G GP F T P + P+
Sbjct: 17369 FAKHLNEGNQ---YLFRVAAENQY------GRGP-----FVETPKP-----IKALDPLHP 17409
Query: 3026 IDPPSSTVQQGQDASFKCLI-----HDGAAPISLEWKTRNQE-LEDNVHISPNGSIITIV 3079
PP D + L+ DG +PI+ +E +D + ++ +V
Sbjct: 17410 PGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNLECVV 17469
Query: 3080 -GTRPSNHGTYRCVASNAYGVAQSVVNLSVHG-----PPTVSV---LPEGPVWVKVGKAV 3130
G + +R A N G+ + + PP+V + L EG V VK G V
Sbjct: 17470 TGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQEKLVPPSVELDVKLIEGLV-VKAGTTV 17528
Query: 3131 TLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNA 3190
+ G P +A+WT S E T + +VL I + D G Y NA
Sbjct: 17529 RFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQITVSNA 17588
Query: 3191 LGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW----- 3245
G+ V + V PG P ++T E T + + +P I++
Sbjct: 17589 AGSKTVAVHLTV---LDVPGPPTGPINILDVTPE-HMTISWQPPKDDGGSPVINYIVEKQ 17644
Query: 3246 --------------SKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATI 3291
SK + +P H +G + A+ G P + T+
Sbjct: 17645 DTRKDTWGVVSSGSSKTKLKIP--HLQKGCEYVFRVRAENKIG------VGPPLDSTPTV 17696
Query: 3292 ILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELL- 3350
H SPP P + T T S GS + G R E+
Sbjct: 17697 AKHKFSPPSPPGKPVVTDITENA---------ATVSWTLPKSDGGSPITGYYMERREVTG 17747
Query: 3351 HFERAAPEDSGRYRCRVT----NKVGSAEAFAQLLV---QGPPGSLPATSIPAGSTPTVQ 3403
+ R + RVT FA+ L + P S P + P
Sbjct: 17748 KWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPP 17807
Query: 3404 VTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP---------PGHSVQDGVLRIQ 3454
+ P+L+ KS + SD G+ + + Q P ++ R+
Sbjct: 17808 INPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVP 17867
Query: 3455 NLDQSCQGTYICQAHGPWGKAQAS--AQLVIQA----LPSVLINIR-TSVQTVVVGHAVE 3507
L + + + +A G+ + A+ VI P V +++ V TV VG +
Sbjct: 17868 GLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIR 17927
Query: 3508 FECLALGDPKPQVTWSKVGGHL----RPGIVQSGGVV--RIAHVELADAGQYRCTATNAA 3561
G P+P +TW+K G L R ++Q V +I AD G+Y +A N++
Sbjct: 17928 ILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSS 17987
Query: 3562 GTTQSHVLLLVQALP 3576
G Q ++ V P
Sbjct: 17988 GHAQGSAIVNVLDRP 18002
Score = 72.8 bits (177), Expect = 7e-12
Identities = 293/1375 (21%), Positives = 491/1375 (35%), Gaps = 235/1375 (17%)
Query: 2355 GQTLDLNCVVPGQSHAQVTWHKRGGSL--PVRHQTHGS----LLRLYQASPADSGEYVCR 2408
G + C+V S A TW K G ++ +H+ L + +D+GEY C
Sbjct: 11133 GSSAIFECLV-SPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCV 11191
Query: 2409 V-LGSSVPLEASVLVTIE-PAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHA 2466
+ LG+ + LV E P V L TV +GQ L L+C +
Sbjct: 11192 LRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTV---------VKGQPLYLSCEL--NKER 11240
Query: 2467 QVTWHKRGGSLPAR--HQVHG--SRLRLLQVTPAD---SGEYVCRVVGSSGTQEASVLVT 2519
V W K G + + V G +R L + AD +G Y V ++ + +S +
Sbjct: 11241 DVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKV 11300
Query: 2520 IQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS--- 2576
++ + P+R + T C +A P+ I W+K +P+
Sbjct: 11301 VEVI-----RDWLVKPIRDQHVKPK----GTAIFACDIAKDTPN-IKWFKGYDEIPAEPN 11350
Query: 2577 -RHQIVGSR----LRIPQVTPADSGEYVCHVSNGA-------GSRETSLIVTIQGSGSSH 2624
+ +I+ L+I P D EY + G RE L+ I+
Sbjct: 11351 DKTEILRDGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREVELLKPIEDVTIYE 11410
Query: 2625 VPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLH 2684
S S I + + GQ ++ P I GG L LH
Sbjct: 11411 KESASFDAEISEAD---IPGQWKLKGELLRPSPTCEIK--AEGGK---------RFLTLH 11456
Query: 2685 QMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETL 2744
++ + +GE + +A N I + +++V + + V E
Sbjct: 11457 KVKLDQAGEVLYQALNAI----TTAILTVKEI---------ELDFAVPLKDVTVPERRQA 11503
Query: 2745 DLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEA 2804
CV+ +A+ V W K + S + AD +++ + S E
Sbjct: 11504 RFECVLTREAN--VIWSKGPDIIKSSDKFD---------IIADGKKHILVINDSQFDDEG 11552
Query: 2805 SVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRG 2864
+E +SA + G V EG+T C + + V W K
Sbjct: 11553 VYTAEVEGKKTSA-RLFVTGIRLKFMSPLEDQTVKEGETATFVCELSHEK-MHVVWFKND 11610
Query: 2865 GNLPARHQV------HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPI 2918
L V L + +V+ D + QV S T + VL
Sbjct: 11611 AKLHTSRTVLISSEGKTHKLEMKEVTLDDISQIKAQVKELSSTAQLKVLE---------- 11660
Query: 2919 PAPGLAQPIY-IEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL--PARHQTHGSQ 2975
A P + ++ E + L C V V W+K G + ++
Sbjct: 11661 -----ADPYFTVKLHDKTAVEKDEITLKCEV--SKDVPVKWFKDGEEIVPSPKYSIKADG 11713
Query: 2976 LRLHL----VSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS 3031
LR L D GEYVC + + +A+ TV E ++ P+ ++
Sbjct: 11714 LRRILKIKKADLKDKGEYVCDCGTD---KTKANVTV-----EARLIKVEKPLYGVE---- 11761
Query: 3032 TVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNGS--IITIVGTRPSNHG 3087
V G+ A F+ + + + +WK + Q L + I +G I+ + + G
Sbjct: 11762 -VFVGETAHFEIELSE--PDVHGQWKLKGQPLTASPDCEIIEDGKKHILILHNCQLGMTG 11818
Query: 3088 TYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARW- 3146
A+NA +S NL V P + + P V V EC + EP+ + RW
Sbjct: 11819 EVSFQAANA----KSAANLKVKELPLIFITPLSDVKVFEKDEAKFECEVSREPK-TFRWL 11873
Query: 3147 --TRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVI-VD 3203
T+ + + E G S + I SA D Y+ A++ + + +E I +
Sbjct: 11874 KGTQEITGDDRFELIKDGTKHS---MVIKSAAFEDEAKYMFEAEDKHTSGKLIIEGIRLK 11930
Query: 3204 TGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSPLPWQHRLE 3259
+ E A TVE H + W K L + + E
Sbjct: 11931 FLTPLKDVTAKEKESAVFTVELSHDNI-----------RVKWFKNDQRLHTTRSVSMQDE 11979
Query: 3260 GDT--LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYAT-TVPEHASVQAGETV 3316
G T + ++ D+ Q A + A+ T++ E PY T + ++ V+ E +
Sbjct: 11980 GKTHSITFKDLSIDDTSQIRVEAMGMSSEAKLTVL---EGDPYFTGKLQDYTGVEKDEVI 12036
Query: 3317 QLQC-LAHGTPPLTFQWSRVGSSLPG------RATARNELLHFERAAPEDSGRYRCRVTN 3369
LQC ++ P+ +W + G + +A + +L ++A D G+Y C
Sbjct: 12037 -LQCEISKADAPV--KWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTC---- 12089
Query: 3370 KVGSAEAFAQLLVQGPPGSL--PATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDR 3427
G+ + +L ++ L P S+ T T + ++ I A+ + +
Sbjct: 12090 DCGTDKTSGKLDIEDREIKLVRPLHSVEVMETETARFETEISEDDIHANWKL-------K 12142
Query: 3428 GTQLRW-----FKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLV 3482
G L KE G++ HS+ VL LDQ+ G QA ++SA L
Sbjct: 12143 GEALLQTPDCEIKEEGKI---HSL---VLHNCRLDQT--GGVDFQA----ANVKSSAHLR 12190
Query: 3483 IQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG---IVQSGGV 3539
++ L+ V TV G F+C + P V W G L P + +S G
Sbjct: 12191 VKPRVIGLLRPLKDV-TVTAGETATFDCELSYEDIP-VEWYLKGKKLEPSDKVVPRSEGK 12248
Query: 3540 VR---IAHVELADAGQYRCTATNAAGTTQSHVLLLVQALP-QISMP-QEVRVPAGSAAVF 3594
V + V+L DAG+ + TA + ++H L V+ P + + P ++ V G+ AV
Sbjct: 12249 VHTLTLRDVKLEDAGEVQLTAKD----FKTHANLFVKEPPVEFTKPLEDQTVEEGATAVL 12304
Query: 3595 PCIASGYPTPDISWSKLDGSLPPDSRLE------NNMLMLPSVRPQDAGTYVCTA 3643
C S + W K + + E L++ P+D TY C A
Sbjct: 12305 ECEVS-RENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDA 12358
Score = 71.2 bits (173), Expect = 2e-11
Identities = 81/305 (26%), Positives = 117/305 (38%), Gaps = 61/305 (20%)
Query: 3414 GASVEFHCAVPS-DRGTQLRWFKEGGQLPPGH----SVQDGV--LRIQNLDQSCQGTYIC 3466
G V++ C + + D+ TQ+ W+ QL + +DGV L ++++ + GTY C
Sbjct: 31582 GGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVAILYVKDITKLDDGTYRC 31641
Query: 3467 QAHGPWGKAQASAQLVIQALPSVL----------INIRTSV----------------QTV 3500
+ +G+ + A+L ++ + V I RT +T
Sbjct: 31642 KVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRLLERPPEFTLPLYNKTA 31701
Query: 3501 VVGHAVEFECLALGDPKPQVTWSKVGGHLRPG-------IVQSGGV--VRIAHVELADAG 3551
VG V F P+P VTW K G ++PG G+ + I V D
Sbjct: 31702 YVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDA 31761
Query: 3552 QYRCTATNAAGTTQSHVLLLVQALP----QISMPQEVRVPA------GSAAVFPCIASGY 3601
+Y A N G L V P P R+ A G + F SG
Sbjct: 31762 EYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGI 31821
Query: 3602 PTPDISWSKLDG---SLPPD-----SRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAF 3653
P P + W K DG SL P+ L+ L + P+D G Y TATN G
Sbjct: 31822 PPPTLKWEK-DGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQ 31880
Query: 3654 AHLQV 3658
AHLQV
Sbjct: 31881 AHLQV 31885
Score = 70.9 bits (172), Expect = 3e-11
Identities = 190/941 (20%), Positives = 318/941 (33%), Gaps = 167/941 (17%)
Query: 2827 PPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGP------LLRL 2880
P ++ SS V GQ L ++ + G+ +TW K G L +++ L +
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSI 23289
Query: 2881 NQVSPADSGEYSCQVTGSSGTLEASV-LVTIEPSSP--GPIPAPGLAQPIYIEASSSHVT 2937
+ D G+Y V G AS+ +VT++ P GP+ ++ + + +
Sbjct: 23290 KETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVSAESITLSWNPPLY 23349
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGP 2997
G N +V + W ++ ++ L + EY R +
Sbjct: 23350 TGGCQITNYIVQKRDTTTTVWDVVSATV--------ARTTLKVTKLKTGTEYQFRIFAEN 23401
Query: 2998 GPEQEASFTVTVPPSEGSSYRLRSP-------VISIDPPSSTVQQGQDASFKCLIHDGAA 3050
Q SF + P + Y + P +I S +Q + +++G +
Sbjct: 23402 RYGQ--SFALESDPIV-AQYPYKEPGPPGTPFATAISKDSMVIQWHEP------VNNGGS 23452
Query: 3051 PI---SLEWKTRNQELEDNVHISPNGSIITIVGTRPSN-----HGTYRCVASNAYGVAQS 3102
P+ LE K RN L V N +II + N +R A N GV ++
Sbjct: 23453 PVIGYHLERKERNSILWTKV----NKTIIHDTQFKAQNLEEGIEYEFRVYAENIVGVGKA 23508
Query: 3103 VVNLSVH---------GPPTVSVLPEGPV---WVKV---GKAVTLECVSAGEPRSSARWT 3147
N + G P ++ + W K G ++ + RW
Sbjct: 23509 SKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWM 23568
Query: 3148 RISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAM 3207
+ S T Q T +S + +A+NA G K + TG +
Sbjct: 23569 KASFTNVIETQFT-----------VSGLTEDQRYEFRVIAKNAAGAISKPSD---STGPI 23614
Query: 3208 APG----APQVQAEEA---ELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE- 3259
P++ + + V AG T L G P PTI W + + R E
Sbjct: 23615 TAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEI 23674
Query: 3260 -----GDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGE 3314
LI+ + D GQYI A++ AG + + V P P VQ
Sbjct: 23675 KNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRP----GPPEGPVQVTG 23730
Query: 3315 TVQLQCLAHGTPPL------------------TFQWSRVGSSLPGRATARNELLHFERAA 3356
+C +PPL W+ V S + + +LL
Sbjct: 23731 VTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLAWTVVASEVVTNSLKVTKLLEGNEYV 23790
Query: 3357 PEDSGRYRCRVTNKVGSAEAFAQ--------LLVQGPPGSLPATSIPAGSTPTVQVTPQL 3408
+R NK G E ++ GPP SL T+I S P
Sbjct: 23791 ------FRIMAVNKYGVGEPLESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDS 23844
Query: 3409 ETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQA 3468
+ G+ + + DR + +RW K + + D LR+ L + + + A
Sbjct: 23845 DG---GSEIIGYIVEKRDR-SGIRWIKCNKR-----RITDLRLRVTGLTEDHEYEFRVSA 23895
Query: 3469 HGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGH 3528
G + S V + +V LA G P S++ G+
Sbjct: 23896 ENAAGVGEPSPATVYYKACDPVFKPGPPTNAHIVDTTKNSITLAWGKPIYD-GGSEILGY 23954
Query: 3529 L---------RPGIVQSGGVVRIAHVELADAGQYR------CT--------ATNAAGTTQ 3565
+ IV +R+ E++ +++ C AT+ GT +
Sbjct: 23955 VVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVK 24014
Query: 3566 SHVLLLVQALPQISMPQEVR----VPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL 3621
L P++ + E+R V AG +A G PTP+I+WS+ +G ++
Sbjct: 24015 PEDKL---EAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQI 24071
Query: 3622 ENNM----LMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
E + L + + DAG Y+ N G AF ++V
Sbjct: 24072 EKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKV 24112
Score = 69.3 bits (168), Expect = 8e-11
Identities = 204/954 (21%), Positives = 337/954 (35%), Gaps = 155/954 (16%)
Query: 2845 DLKCVVP--GQAHAQVTWHKRGGNLPARHQV--------HGPLLRLNQVSPADSGEYSCQ 2894
DLK VP G+ VTWHK N+P + + LL + D G Y +
Sbjct: 22164 DLKVDVPFIGRPTPAVTWHK--DNVPLKQTTRVNAESTENNSLLTIKDACREDVGHYVVK 22221
Query: 2895 VTGSSGTL--EASVLVTIEPSSP-GPIPAPGL-AQPIYIEASSSHVTEGQTLDLNCVVPG 2950
+T S+G +V+V +P P GP+ + A I + G +++ N +V
Sbjct: 22222 LTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSITLSWGPPKYDGGSSIN-NYIVEK 22280
Query: 2951 QAHAQVTWYKRGGSLPARHQTHGSQLRL---HLVSPADSGEYVCRAASGPGPEQEASFTV 3007
+ + TW ++ AR +L+ + A Y P A +
Sbjct: 22281 RDTSTTTWQIVSATV-ARTTIKACRLKTGCEYQFRIAAENRYGKSTYLNSEPTV-AQYPF 22338
Query: 3008 TVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPI---SLEWKTRNQELE 3064
VP G+ PV+++ S Q + I DG + + LE K RN L
Sbjct: 22339 KVPGPPGT------PVVTLSSRDSMEVQWNEP-----ISDGGSRVIGYHLERKERNSILW 22387
Query: 3065 DNVHISPNGSI-ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVH---------GPPTV 3114
++ +P G +R A N G+ + + G P
Sbjct: 22388 VKLNKTPIPQTKFKTTGLEEGVEYEFRVSAENIVGIGKPSKVSECYVARDPCDPPGRPEA 22447
Query: 3115 SVLPEGPV---WVKV----GKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSH 3167
++ V W K G +T V E RW + S T ++D+H
Sbjct: 22448 IIVTRNSVTLQWKKPTYDGGSKITGYIVEKKE-LPEGRWMKASFT---------NIIDTH 22497
Query: 3168 AVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAP----GAPQVQAE---EAE 3220
+++ + +A+NA G + E TGA+ P++ + +
Sbjct: 22498 --FEVTGLVEDHRYEFRVIARNAAGVFSEPSE---STGAITARDEVDPPRISMDPKYKDT 22552
Query: 3221 LTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE------GDTLIIPRVAQQDSG 3274
+ V AG + + G P PTI W K L RLE +L + + DSG
Sbjct: 22553 IVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATSLSVKDAVRVDSG 22612
Query: 3275 QYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSR 3334
YI A + AG T+ + V P PE V +G T + +C PPL
Sbjct: 22613 NYILKAKNVAGERSVTVNVKVLDRP---GPPEGPVVISGVTAE-KCTLAWKPPL----QD 22664
Query: 3335 VGSSLPGRATARNELLHFERAAPEDSGR-YRCRVTNKVGSAEAFAQLL------VQGPPG 3387
GS + R E + + + C+VT + E +++ V P
Sbjct: 22665 GGSDIINYIVERRETSRLVWTVVDANVQTLSCKVTKLLEGNEYTFRIMAVNKYGVGEPLE 22724
Query: 3388 SLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWF------KEGGQLP 3441
S P + P P++ T + + + SD G+++ + KEG +
Sbjct: 22725 SEPVVAKNPFVVPDAPKAPEVTTVTKDSMIVVWERPASDGGSEILGYVLEKRDKEGIRWT 22784
Query: 3442 PGHSVQDGVLRIQ--NLDQSCQGTYICQAHGPWGKAQASAQLVIQAL------------P 3487
H G LR++ L ++ + A G ++ S Q P
Sbjct: 22785 RCHKRLIGELRLRVTGLIENHDYEFRVSAENAAGLSEPSPPSAYQKACDPIYKPGPPNNP 22844
Query: 3488 SVLINIRTSV-----------QTVVVGHAVEFECLALGD---PKPQVTWSKVGGHLRPGI 3533
V+ R+SV + G+ VE +++G+ P +K + +
Sbjct: 22845 KVIDITRSSVFLSWSKPIYDGGCEIQGYIVEKCDVSVGEWTMCTPPTGINKTNIEVEKLL 22904
Query: 3534 VQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVR----VPAG 3589
+ RI + A G++ A ++ P I + E+R + AG
Sbjct: 22905 EKHEYNFRICAINKAGVGEH-------ADVPGPIIVEEKLEAPDIDLDLELRKIINIRAG 22957
Query: 3590 SAAVFPCIASGYPTPDISWSKLDGSLPP----DSRLENNMLMLPSVRPQDAGTYVCTATN 3645
+ G PTP++ W K+DG + D L+L +V D+G Y T N
Sbjct: 22958 GSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLEN 23017
Query: 3646 RQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADG 3699
G AF ++V + P P + KD+ + IT+ P DG
Sbjct: 23018 SSGTKSAFVTVRVLDTPSP-----PVNLKVTEITKDS-----VSITWEPPLLDG 23061
Score = 67.4 bits (163), Expect = 3e-10
Identities = 98/433 (22%), Positives = 168/433 (38%), Gaps = 62/433 (14%)
Query: 2827 PPIRIEPSSSR---VAEGQTLDLKCVVPGQAHAQVTWHKRG-GNLPARHQVH----GPLL 2878
P I ++ S + V G + L +V G+ +VTW K G N+ + QV L
Sbjct: 18604 PEIDLDASMRKLVIVRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFL 18663
Query: 2879 RLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEP-SSPGPIPAPGLAQPIYIEASSSHVT 2937
+ + DSG+YS + +G E +V V + +PGP+ ++ + +S HV+
Sbjct: 18664 VIPNSTRDDSGKYSLTLVNPAG--EKAVFVNVRVLDTPGPVSDLKVSD---VTKTSCHVS 18718
Query: 2938 ------EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVC 2991
+G + + +V + + TW + + H+ + EY
Sbjct: 18719 WAPPENDGGSQVTHYIVEKREADRKTW--------STVTPEVKKTSFHVTNLVPGNEYYF 18770
Query: 2992 RAAS----GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS---TVQQGQDASFKCL 3044
R + GPG VP P+ DPP T A+ L
Sbjct: 18771 RVTAVNEYGPG----------VPTDVPKPVLASDPLSEPDPPRKLEVTEMTKNSATLAWL 18820
Query: 3045 --IHDGAAPISLEWKTRNQELEDNVHISPNGSII-----TIVGTRPSNHGTYRCVASNAY 3097
+ DG A I + T +E E S++ + G + +R A NA
Sbjct: 18821 PPLRDGGAKID-GYITSYREEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAV 18879
Query: 3098 GV-----AQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISST 3152
GV A+ V P ++PE + +K GK + +E G+P + +W +
Sbjct: 18880 GVSLPREAEGVYEAKEQLLPPKILMPE-QITIKAGKKLRIEAHVYGKPHPTCKWKKGEDE 18938
Query: 3153 PAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAP 3212
DS ++L I D+G Y A+N+ GT ++++V+V APG P
Sbjct: 18939 VVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVV---MDAPGPP 18995
Query: 3213 QVQAEEAELTVEA 3225
Q + +++ +A
Sbjct: 18996 QPPFDISDIDADA 19008
Score = 67.4 bits (163), Expect = 3e-10
Identities = 299/1517 (19%), Positives = 524/1517 (34%), Gaps = 216/1517 (14%)
Query: 2206 HQVTPADSGEYVCHVV------GTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEG 2259
H VT + GE + G S P E VT++ + I + + V G
Sbjct: 29694 HTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIHVPAG 29753
Query: 2260 QTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQASPADAGQYVCRA 2313
+ ++L +AG+ +W+ G L +V + ++L I + + D G+Y
Sbjct: 29754 RPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRETTIRDTGEYTLEL 29813
Query: 2314 SNGMEASITVTVTGTQGANLAY-----PAGSTQPIRIEPSSSQVA----EGQTLDLNCVV 2364
N VTGT + P T PI+I+ + E LD +
Sbjct: 29814 KN---------VTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEPPELDGGAPL 29864
Query: 2365 PGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVT- 2423
G Q H R G LPV S + + + + EYV RV ++ S L +
Sbjct: 29865 SGYVVEQRDAH-RPGWLPVSESVTRSTFKFTRLT--EGNEYVFRVAATNRFGIGSYLQSE 29921
Query: 2424 -IEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQ 2482
IE S+ G T++I S +G TL +QVT G + R +
Sbjct: 29922 VIECRSSIRIPGPPETLQIFDVSR---DGMTLTWYP-PEDDGGSQVT-----GYIVERKE 29972
Query: 2483 VHGSRLRLLQVTPADSGEYVCRVVG-SSGTQEASVLVTIQQRLSGSHSQG-----VAYPV 2536
V R + P Y R G + G + + I R SG S+ P+
Sbjct: 29973 VRADRWVRVNKVPVTMTRY--RSTGLTEGLEYEHRVTAINARGSGKPSRPSKPIVAMDPI 30030
Query: 2537 RIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSG 2596
+ T + +A P K G L ++ TP
Sbjct: 30031 APPGKPQNPRVTDTTRTSVSLAWSVPEDEGGSKVTGYLIEMQKVDQHEWTKCNTTPTKIR 30090
Query: 2597 EY-VCHVSNGAGSRETSLIVTIQGSGS-SHVPSVS--------PPIRIESSSPT---VVE 2643
EY + H+ GA R L G G + VP P ++ V +
Sbjct: 30091 EYTLTHLPQGAEYRFRVLACNAGGPGEPAEVPGTVKVTEMLEYPDYELDERYQEGIFVRQ 30150
Query: 2644 GQTLDLNCVVARQPQAIITWYKRGGSLPSR-----HQTHGSHLRLHQMSVADSGEYVCRA 2698
G + L + +P I W K G + R +TH + L + + DSG Y
Sbjct: 30151 GGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETH-TELVIKEADRGDSGTYDLVL 30209
Query: 2699 NNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH----VAEGETLDLNCVVPGQA 2754
N I + V S SP P I++ S +G L ++ +
Sbjct: 30210 ENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILERRE 30269
Query: 2755 HAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRV-----MGSSGPLEASVLVT 2809
+ W+ + RG+ L + + ++ EY RV G S PL++ VT
Sbjct: 30270 VPKAAWYTIDS------RVRGTSLVVKGLK--ENVEYHFRVSAENQFGISKPLKSEEPVT 30321
Query: 2810 IEASGSSAVHVPAPGGAPPIRIEPSSSRVA--------EGQTLDLKCVVPGQAHAQVTWH 2861
+ + ++ P P PP ++ + S V+ +G + + + + W
Sbjct: 30322 PK----TPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKWV 30377
Query: 2862 KRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQV-----TGSSGTLEASVLVTIE----- 2911
+ + Q+ + + + P EY ++ G S T AS V +
Sbjct: 30378 RHN-----KTQITTTMYTVTGLVP--DAEYQFRIIAQNDVGLSETSPASEPVVCKDPFDK 30430
Query: 2912 PSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQT 2971
PS PG + +++ +G L V + W K + +
Sbjct: 30431 PSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSN-----KERI 30485
Query: 2972 HGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS 3031
Q + + A E+ A + G + +++ S +P I +
Sbjct: 30486 KDKQFTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSG---EAPGIRKEMKDV 30542
Query: 3032 TVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN--VHISPNGSI--ITIVGTRPSNHG 3087
T + G+ A C I P ++W +EL + +S +G +T++ + G
Sbjct: 30543 TTKLGEAAQLSCQIVGRPLP-DIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEG 30601
Query: 3088 TYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVK----VGKAVTLECVSAGEPRSS 3143
Y C+A+N G ++ L + P P P+ K VG + L + G P +
Sbjct: 30602 VYTCIATNEVGEVETSSKLLLQATPQFH--PGYPLKEKYYGAVGSTLRLHVMYIGRPVPA 30659
Query: 3144 ARWTRISSTPAKLEQRTYGLMDSHAVLQISSA-KPSDAGTYVCLAQNALGTAQKQVEVIV 3202
W E T + + L + + + + AG Y N GT ++V +
Sbjct: 30660 MTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDAILDVEI 30719
Query: 3203 DTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAP------------TIHWSKLRS 3250
P P + +EA L+ SA S P + + +
Sbjct: 30720 QDKPDKPTGP--------IVIEA----LLKNSAVISWKPPADDGGSWITNYVVEKCEAKE 30767
Query: 3251 PLPWQHRLEGDTLIIPRVAQ--QDSGQYIC----NATSPAGHAEATIILHVESPPYATTV 3304
WQ ++ R+ +++G Y N + E + ++ ++SP
Sbjct: 30768 GAEWQLVSSAISVTTCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVVIIKSPFEKPGA 30827
Query: 3305 PEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSS-LPGRATARNELLHFERAAPEDSGRY 3363
P ++ A + C+ PP + +++ + L R +N+ + E+
Sbjct: 30828 PGKPTITA--VTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWIS---VTTEEIRET 30882
Query: 3364 RCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQV---TPQLETKSIGASVEFH 3420
V N + E ++ + G + I TP V P + + +V +
Sbjct: 30883 VFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEELRNLNVRYQ 30942
Query: 3421 ------CAVPSDRGTQLRWFKEGGQLPPGHSVQDGV-------------LRIQNLDQSCQ 3461
C V ++W+++G ++ + DG+ L I ++
Sbjct: 30943 SNATLVCKVTGHPKPIVKWYRQGKEI-----IADGLKYRIQEFKGGYHQLIIASVTDDDA 30997
Query: 3462 GTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLAL-----GDP 3516
Y +A G +A L ++ I++ +++ + HA+ E +++ G P
Sbjct: 30998 TVYQVRATNQGGSVSGTASLEVEV--PAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKP 31055
Query: 3517 KPQVTWSK------VGGHLRPGIVQS-GGVVRIAHVELADAGQYRCTATNAAGTTQSHVL 3569
P +TW K GH + + +S +V VE DAG Y A N G Q V
Sbjct: 31056 DPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVE 31115
Query: 3570 LLVQALPQISMPQEVRV 3586
L V +P P+ V+V
Sbjct: 31116 LDVADVP--DPPRGVKV 31130
Score = 65.9 bits (159), Expect = 9e-10
Identities = 140/671 (20%), Positives = 246/671 (36%), Gaps = 93/671 (13%)
Query: 3056 WKTRNQE-LEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGV------AQSVVNLSV 3108
WK N+E ++D TI G + +R A N G+ A S+
Sbjct: 30477 WKKSNKERIKDKQ--------FTIGGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLT 30528
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHA 3168
G V K+G+A L C G P +W R ++ R Y +
Sbjct: 30529 SGEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKE--LIQSRKYKMSSDGR 30586
Query: 3169 V--LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVD-TGAMAPGAPQVQAEEAELTVEA 3225
L + + + D G Y C+A N +G + ++++ T PG P + +
Sbjct: 30587 THTLTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAV---- 30642
Query: 3226 GHTATLRCSATGSPAPTIHWSKLRSPLPWQHRL-----EGDTLIIPRVAQQDS--GQYIC 3278
G T L G P P + W + L + E T ++ + Q+ + G+Y
Sbjct: 30643 GSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKV 30702
Query: 3279 NATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSS 3338
++ G +A + + ++ P T P + ++ + PP S + +
Sbjct: 30703 QLSNVFGTVDAILDVEIQDKPDKPTGP----IVIEALLKNSAVISWKPPADDGGSWITNY 30758
Query: 3339 LPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG---SLPATSIP 3395
+ + A+ E ++ + S CR+ N +A + ++ Q G L +S+
Sbjct: 30759 VVEKCEAK-EGAEWQLVSSAISVT-TCRIVNLTENAGYYFRVSAQNTFGISDPLEVSSVV 30816
Query: 3396 AGSTPTVQVTPQLETK-SIGASVEFHCAVP-----SDRGTQLR-WFKEGGQLPPG----- 3443
+P + P K +I A + C V SD G ++R ++ E +
Sbjct: 30817 IIKSPFEK--PGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKKQNKWISV 30874
Query: 3444 --HSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQAS---------AQLVIQA--LPSVL 3490
+++ V ++NL + + + + G+++ S + + IQA L
Sbjct: 30875 TTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPHFKEEL 30934
Query: 3491 INIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQ------SGGV--VRI 3542
N+ Q+ C G PKP V W + G + ++ GG + I
Sbjct: 30935 RNLNVRYQSNAT-----LVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLII 30989
Query: 3543 AHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ------EVRVPAGSAAVFPC 3596
A V DA Y+ ATN G+ L V+ +I +P+ V G
Sbjct: 30990 ASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKI 31049
Query: 3597 IASGYPTPDISWSKLDGSLPPD-------SRLENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
SG P P I+W K + + +R +++ V +DAG YV A NR G
Sbjct: 31050 PFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRFGI 31109
Query: 3650 VKAFAHLQVPE 3660
+ L V +
Sbjct: 31110 DQKTVELDVAD 31120
Score = 65.1 bits (157), Expect = 1e-09
Identities = 184/907 (20%), Positives = 333/907 (36%), Gaps = 138/907 (15%)
Query: 2808 VTIEASG-SSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGN 2866
+ +EA G SS + G P + E + L+C + +A A V W K G
Sbjct: 11998 IRVEAMGMSSEAKLTVLEGDPYFTGKLQDYTGVEKDEVILQCEI-SKADAPVKWFKDGKE 12056
Query: 2867 L-PARHQV-----HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPA 2920
+ P+++ V +L L + +D G+Y+C GT + S + IE
Sbjct: 12057 IKPSKNAVIKADGKKRMLILKKALKSDIGQYTCDC----GTDKTSGKLDIEDREIK---- 12108
Query: 2921 PGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHL 2980
L +P++ S V E +T + + W +G +L QT +++
Sbjct: 12109 --LVRPLH----SVEVMETETARFETEI-SEDDIHANWKLKGEALL---QTPDCEIK--- 12155
Query: 2981 VSPADSGE------YVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS--T 3032
+ G+ + CR G + +A+ + R++ VI + P T
Sbjct: 12156 ----EEGKIHSLVLHNCRLDQTGGVDFQAANV-----KSSAHLRVKPRVIGLLRPLKDVT 12206
Query: 3033 VQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGS----IITIVGTRPSNHGT 3088
V G+ A+F C + P+ EW + ++LE + + P +T+ + + G
Sbjct: 12207 VTAGETATFDCELSYEDIPV--EWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGE 12264
Query: 3089 YRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR 3148
+ A + ++ NL V PP P V+ G LEC + E + +W +
Sbjct: 12265 VQLTAKDF----KTHANLFVKEPPVEFTKPLEDQTVEEGATAVLECEVSRE-NAKVKWFK 12319
Query: 3149 ISSTPAKLEQRTYGLMDSHAV--LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGA 3206
+ L+ + Y ++ V L I P D TY C A++ + V
Sbjct: 12320 NGTEI--LKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNV-------- 12369
Query: 3207 MAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK----LRSPLPWQHRLEGDT 3262
P + +L V A C + A + W K ++ + +G
Sbjct: 12370 -VPPHVEFLRPLTDLQVREKEMARFECELSRENAK-VKWFKDGAEIKKGKKYDIISKGAV 12427
Query: 3263 --LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQC 3320
L+I + D +Y C + T++ E T + V +T++L C
Sbjct: 12428 RILVINKCLLDDEAEYSCEVRTARTSGMLTVL---EEEAVFTKNLANIEVSETDTIKLVC 12484
Query: 3321 LAHGTPPLTFQWSRVGSSL--PGR----ATARNELLHFERAAPEDSGRYRCRVTNKVGSA 3374
P W + + GR R +L + A ED+G Y CR+ +
Sbjct: 12485 EV-SKPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPS----- 12538
Query: 3375 EAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWF 3434
G + + A Q LE G EF C++ S ++W
Sbjct: 12539 --------SRTDGKVKVHELAAEFISKPQNLEILE----GEKAEFVCSI-SKESFPVQWK 12585
Query: 3435 KEGGQLPPGHS---VQDG---VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
++ L G + DG VL +++ GTY+ G A+A+A L +
Sbjct: 12586 RDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMV----GAARAAAHLTVIEKLR 12641
Query: 3489 VLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK----VGGHLRPGIVQSGGV--VRI 3542
+++ ++ + V V F C + + W + + + I+Q V +RI
Sbjct: 12642 IVVPLKDT--RVKEQQEVVFNC-EVNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRI 12698
Query: 3543 AHVELADAGQYRCTATNAAG---TTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIAS 3599
L D Y + TN G + +++++ + L + +++ + F C +
Sbjct: 12699 RDAHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVN 12758
Query: 3600 GYPTPDISWSKLDGSLPPDSRLE------NNMLMLPSVRPQDAGTYVCTATNRQGKVKAF 3653
+ W+K +P D+R+ +ML + D G Y+ TA G+ K+
Sbjct: 12759 RL-NVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTA----GQDKSV 12813
Query: 3654 AHLQVPE 3660
A L + E
Sbjct: 12814 AELLIIE 12820
Score = 62.8 bits (151), Expect = 7e-09
Identities = 78/307 (25%), Positives = 127/307 (41%), Gaps = 37/307 (12%)
Query: 3385 PPGSLPAT----SIPAGSTPTVQVTPQLETKSIGASVEFHCAV-PSDRGTQLRWFKEGGQ 3439
PP P T ++P ++ E++ +G+S F C V PS T W K+G
Sbjct: 11100 PPDEAPFTYQLKAVPLKFVKEIKDIILTESEFVGSSAIFECLVSPSTAITT--WMKDGSN 11157
Query: 3440 L---PPGHSVQDGV---LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINI 3493
+ P + DG L I ++ S G Y C + ++A+LV++ LP +
Sbjct: 11158 IRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCVLRLGNKEKTSTAKLVVEELPVRFVKT 11217
Query: 3494 RTSVQTVVVGHAVEFECLALGDPKPQVTWSKVG-------GHLRPGIVQSGGVVRIAHVE 3546
TVV G + C + + V W K G G + PG++ + I +
Sbjct: 11218 LEEEVTVVKGQPLYLSCEL--NKERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDAD 11275
Query: 3547 LADAGQYRCTATNAAGTTQSHVLLLVQALPQ--ISMPQEVRVPAGSAAVFPCIASGYPTP 3604
DAG Y T NA S + +V+ + + ++ V A+F C + TP
Sbjct: 11276 DTDAGTYTVTVENANNLECSSCVKVVEVIRDWLVKPIRDQHVKPKGTAIFACDIA-KDTP 11334
Query: 3605 DISWSKLDGSLP--PDSRLE-----NNM-LMLPSVRPQDAGTYVCTATNRQGKVKAFAHL 3656
+I W K +P P+ + E N++ L + + P+D Y A +GK + A L
Sbjct: 11335 NIKWFKGYDEIPAEPNDKTEILRDGNHLYLKIKNAMPEDIAEY---AVEIEGK-RYPAKL 11390
Query: 3657 QVPERVV 3663
+ ER V
Sbjct: 11391 TLGEREV 11397
Score = 62.4 bits (150), Expect = 1e-08
Identities = 104/447 (23%), Positives = 159/447 (35%), Gaps = 91/447 (20%)
Query: 3297 SPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSR----VGSSLPGRATARNEL--L 3350
+PP + ++ +V GE+V L+C G P T W R + SS+ + T ++ + L
Sbjct: 941 TPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARL 1000
Query: 3351 HFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQ-GPPGSLPATSIPAGST---------- 3399
A EDSGR+ C N+ G+ L VQ T++ T
Sbjct: 1001 MIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESR 1060
Query: 3400 ---------------PTVQVTPQLETKSI------GASVEFHCAVPSDRGTQLRWFKEGG 3438
P P TK + G SV F C V + + W K G
Sbjct: 1061 DVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGV 1120
Query: 3439 QLPPG------HSVQDG----VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
L G ++ Q G V+ + D + G Y G+ ASA L+ +A
Sbjct: 1121 PLTTGYRYKVSYNKQTGECKLVISMTFADDA--GEYTIVVRNKHGETSASASLLEEADYE 1178
Query: 3489 VLINIRTSV--QTVVVGHAVEFECLALGDPKPQVTWS-------KVGGHLRPGIVQSGGV 3539
+L+ + + QT V E + +G+ P +S K +R + + V
Sbjct: 1179 LLMKSQQEMLYQTQVTAFVQEPK---VGETAPGFVYSEYEKEYEKEQALIRKKMAKDTVV 1235
Query: 3540 VRIAHVE------------LADAGQYRCTATNAA------GTTQSHVLLLVQALPQISMP 3581
VR +VE L +YR T G + V + +
Sbjct: 1236 VR-TYVEDQEFHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFD 1294
Query: 3582 QEV---RVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNMLM-------LPSV 3631
+ R+ G F C SGYP P I+W K + R + + L +P V
Sbjct: 1295 SRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVV 1354
Query: 3632 RPQDAGTYVCTATNRQGKVKAFAHLQV 3658
P+D G Y A+N +G L V
Sbjct: 1355 LPEDEGIYTAFASNIKGNAICSGKLYV 1381
Score = 62.4 bits (150), Expect = 1e-08
Identities = 294/1565 (18%), Positives = 535/1565 (34%), Gaps = 262/1565 (16%)
Query: 2162 HVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH----QTHGSLLRLHQVTPADSGEYV 2217
++ G +L L + G+ +V W K G + + + L L V DSG+Y
Sbjct: 22953 NIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYT 23012
Query: 2218 CHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVT 2277
+ +SG A V V V+ P PPV ++ + T + +T
Sbjct: 23013 LTLENSSGTKSAFVTVR----VLDTPSPPVNLKVTEIT---------------KDSVSIT 23053
Query: 2278 WYKR---GGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVT---------- 2324
W GGS + YI + A Y +N + S +
Sbjct: 23054 WEPPLLDGGSK--------IKNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYF 23105
Query: 2325 -VTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR---GGS 2380
VT + PA + PI++ + D+ ++ ++W K GGS
Sbjct: 23106 RVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVT-----RNSVSLSWTKPEHDGGS 23160
Query: 2381 --------LPVRHQTHGS------LLRLYQASPADSGEYVCRVL-----GSSVPLEASVL 2421
+ +H S L+ + EY+ RV+ G S P +V
Sbjct: 23161 KIIQYIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDPRSLAVP 23220
Query: 2422 VTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARH 2481
+ + L + P V+ SS V GQ L + ++G+ +TW K G L
Sbjct: 23221 IVAKD------LVIEPDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTT 23274
Query: 2482 QVHGS------RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYP 2535
+++ + L + + D G+Y V G + AS+ + +
Sbjct: 23275 RINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDD 23334
Query: 2536 VRIESSSAS----LANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVT 2591
V ES + S L G N +V + T W + + + L++ ++
Sbjct: 23335 VSAESITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSAT------VARTTLKVTKLK 23388
Query: 2592 PADSGEYVCHVSNGAGSR---ETSLIVTIQG------SGSSHVPSVSPPIRIESSSPTVV 2642
++ N G E+ IV G+ ++S + V
Sbjct: 23389 TGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVN 23448
Query: 2643 EGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNI 2702
G + + + R+ + I W K ++ H + + + E+ A N +
Sbjct: 23449 NGGSPVIGYHLERKERNSILWTKVNKTI-----IHDTQFKAQNLEEGIEYEFRVYAENIV 23503
Query: 2703 DALEASIVISVSPSAGSPSAPGSSMPIRIESS------SSHVAEGETLDLNCVVPGQAHA 2756
+AS + PG+ PI ++ + + V +G ++ +V +
Sbjct: 23504 GVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLP 23563
Query: 2757 QVTWHKRGGSLPSHHQ------TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTI 2810
W K + Q T R ++ +G + + S+GP+ A
Sbjct: 23564 DGRWMKASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGA-ISKPSDSTGPITAK----- 23617
Query: 2811 EASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP-- 2868
V +P P R + V G+T L+ V G+ + W + +
Sbjct: 23618 -----DEVELPRISMDPKFR---DTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEES 23669
Query: 2869 ARHQVHGP----LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTI--EPSSP-GPIPAP 2921
AR ++ LL + D G+Y + + +G+ V V + P P GP+
Sbjct: 23670 ARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVT 23729
Query: 2922 GLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLV 2981
G+ S + +G + + VV + +++ W ++ A S L +
Sbjct: 23730 GVTSEKCSLTWSPPLQDGGSDISHYVVEKRETSRLAW-----TVVASEVVTNS---LKVT 23781
Query: 2982 SPADSGEYVCRAAS----GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS--TVQQ 3035
+ EYV R + G G P E + +++P + PP S
Sbjct: 23782 KLLEGNEYVFRIMAVNKYGVGE-----------PLESAPVLMKNPFVLPGPPKSLEVTNI 23830
Query: 3036 GQDASFKCLIH---DGAAPISLEWKTRNQELEDNVHISPNGSIIT-----IVGTRPSNHG 3087
+D+ C DG + I + + ++ I N IT + G +
Sbjct: 23831 AKDSMTVCWNRPDSDGGSEI-IGYIVEKRDRSGIRWIKCNKRRITDLRLRVTGLTEDHEY 23889
Query: 3088 TYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWT 3147
+R A NA GV + P TV PV+ K G V + + W
Sbjct: 23890 EFRVSAENAAGVGEP-------SPATVYYKACDPVF-KPGPPTNAHIVDTTKNSITLAWG 23941
Query: 3148 R-----------ISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTY------VCLAQNA 3190
+ K ++ + ++ L+++ + S + VC A N
Sbjct: 23942 KPIYDGGSEILGYVVEICKADEEEWQIVTPQTGLRVTRFEISKLTEHQEYKIRVC-ALNK 24000
Query: 3191 LGTAQKQVEVIVDTGAMAPGAPQVQAEEAEL--------TVEAGHTATLRCSATGSPAPT 3242
+G E G + P +++A E +L V AG +A + G P P
Sbjct: 24001 VGLG----EATSVPGTVKP-EDKLEAPELDLDSELRKGIVVRAGGSARIHIPFKGRPTPE 24055
Query: 3243 IHWSKLRSPLPWQHRLEGDT----LIIPRVAQQDSGQYICNATSPAGHAEATI---ILHV 3295
I WS+ + ++E L I + D+G+YI + +G A + +L
Sbjct: 24056 ITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDT 24115
Query: 3296 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL----LH 3351
PP V E A + + G + + S+ A ++
Sbjct: 24116 PGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFK 24175
Query: 3352 FERAAPEDSGRYRCRVTNKVG------SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVT 3405
E +R N+ G + +A PPG + T + S +
Sbjct: 24176 VENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAEPPSPPGKVTLTDVSQTSASLMWEK 24235
Query: 3406 PQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYI 3465
P+ + G+ V + +GT+ +W + V + V + L + +
Sbjct: 24236 PEHDG---GSRVLGYVVEMQPKGTE-KW-----SIVAESKVCNAV--VTGLSSGQEYQFR 24284
Query: 3466 CQAHGPWGKAQA--------SAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPK 3517
+A+ GK+ + L IQ PS+ + T ++ G ++ E +G P+
Sbjct: 24285 VKAYNEKGKSDPRVLGVPVIAKDLTIQ--PSLKLPFNT--YSIQAGEDLKIEIPVIGRPR 24340
Query: 3518 PQVTWSKVGGHLRPGI---VQSGGVVRIAHVELA---DAGQYRCTATNAAGTTQSHVLLL 3571
P ++W K G L+ V+ + H++ D G+Y TATN+AGT ++ ++
Sbjct: 24341 PNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVI 24400
Query: 3572 VQALP 3576
V P
Sbjct: 24401 VLEKP 24405
Score = 62.0 bits (149), Expect = 1e-08
Identities = 262/1300 (20%), Positives = 437/1300 (33%), Gaps = 203/1300 (15%)
Query: 2022 FYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT---EGQTLDLNCVVAGSA 2078
F +C S A + V++ PP +++++ V TL L + G
Sbjct: 25076 FRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRP 25135
Query: 2079 HAQVTWYRRGGSLPPHTQVHGSR----LRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
+V W + G L Q+ + L + V+ DSG Y +EN SG K A + V V
Sbjct: 25136 EPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRV 25195
Query: 2135 LHGTHSGPSYT--PVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQ-----AHAQVTWHK 2187
L + + T V + + EP + +G N +V + A+A +T +
Sbjct: 25196 LDSPSAPVNLTIREVKKDSVTLSWEPP---LIDGGAKITNYIVEKRETTRKAYATITNNC 25252
Query: 2188 RGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
+ + G + S EY G P E + V + P+PP
Sbjct: 25253 TKTTFRIENLQEGCSYYFRVLA---SNEY-----GIGLPAETTEPVKVSEP----PLPPG 25300
Query: 2248 RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKR---GGSLPARH----QVRGSRLYIFQ 2300
R+ + V + A + W K GGS + Q +GS +
Sbjct: 25301 RV---------------TLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKWSTC 25345
Query: 2301 ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGS---TQPIRIEPS------SSQ 2351
+ + G E V +G + G + I I+PS +
Sbjct: 25346 TQVKTLEATISGLTAGEEYVFRVAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFN 25405
Query: 2352 VAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSL------LRLYQASPADSGEY 2405
V + L ++ G+ A V W K G +L + + S L + +AS D G Y
Sbjct: 25406 VKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTY 25465
Query: 2406 VCRVLGSS----VPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVA 2461
V S+ VP+ VL P G + V+ S + +G N +V
Sbjct: 25466 ELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVE 25525
Query: 2462 GQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVV-----GSSGTQEASV 2516
+ TWH V + ++++++T EY RV G S E+S
Sbjct: 25526 KKETTSTTWHI------VSQAVARTSIKIVRLTTGS--EYQFRVCAENRYGKSSYSESSA 25577
Query: 2517 LVTIQQRLSGSHSQGVAYPVRIESSSASLA------NGHTLDLNCLVASQAPHTITWYKR 2570
+V + S G V S+ + +G + + + + +I W K
Sbjct: 25578 VVA-EYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKA 25636
Query: 2571 GGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVT-------IQGSGSS 2623
L I +++++ + EY + N AG + S G
Sbjct: 25637 NKIL-----IADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARDPCDPPGQP 25691
Query: 2624 HVPSVS-PPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLR 2682
V +++ + ++ S P G + +V R+ W K + ++
Sbjct: 25692 EVTNITRKSVSLKWSKPHYDGGAKIT-GYIVERRELPDGRWLKCNYT-----NIQETYFE 25745
Query: 2683 LHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH----- 2737
+ +++ E+ A N D+ V S S G P R+
Sbjct: 25746 VTELTEDQRYEFRVFARNAADS-----VSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIV 25800
Query: 2738 VAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR------GSRLRLHHVSPADSGEY 2791
V GE L +N + G+ ++W K G + +T + L + D+G+Y
Sbjct: 25801 VKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQY 25860
Query: 2792 VCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKC-VV 2850
V + +G +V + G + S R E D+ +V
Sbjct: 25861 VLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEINGLTAEKCSLSWGRPQEDGGADIDYYIV 25920
Query: 2851 PGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSS--GTLEASVLV 2908
+ + + W G L LL+ N EY +VTG + G E V
Sbjct: 25921 EKRETSHLAWTICEGELQMTSCKVTKLLKGN--------EYIFRVTGVNKYGVGEPLESV 25972
Query: 2909 TIEPSSPGPIPAPGLAQPIYIEASSSHV-------TEGQTLDLNCVVPGQAHAQVTWYKR 2961
I+ P +P+P + I S ++G + ++ + + W R
Sbjct: 25973 AIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWV-R 26031
Query: 2962 GGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRS 3021
P LR+ + EY R + E + +++P R
Sbjct: 26032 VNKKPVY------DLRVKSTGLREGCEYEYRVYA------ENAAGLSLPSETSPLIRAED 26079
Query: 3022 PVISIDPPSST--VQQGQDA---SFKCLIHDGAAPIS-----------LEWKTRNQELED 3065
PV PPS V G+ ++ + DG API+ +WKT Q L
Sbjct: 26080 PVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYKKSDDTDWKTSIQSLR- 26138
Query: 3066 NVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVW-- 3123
G+ TI G +R + N G + + P E P++
Sbjct: 26139 -------GTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSD---PQIAKEREEEPLFDI 26188
Query: 3124 ---------VKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTY-GLMDSHAVLQIS 3173
VK G + T+ G P + W S L R Y DS L I
Sbjct: 26189 DSEMRKTLIVKAGASFTMTVPFRGRPVPNVLW---SKPDTDLRTRAYVDTTDSRTSLTIE 26245
Query: 3174 SAKPSDAGTYVCLAQNALGTAQKQVEV-IVDTGAMAPGAP 3212
+A +D+G Y QN L A + V ++DT PG P
Sbjct: 26246 NANRNDSGKYTLTIQNVLSAASLTLVVKVLDT----PGPP 26281
Score = 61.6 bits (148), Expect = 2e-08
Identities = 316/1584 (19%), Positives = 540/1584 (34%), Gaps = 291/1584 (18%)
Query: 2163 VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHG-----SLLRLHQVTPADSGEYV 2217
V G + L +V G+ +VTW K G R + L + T DSG+Y
Sbjct: 18618 VRAGCPIRLFAIVRGRPAPKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYS 18677
Query: 2218 CHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVA-----GQA 2272
+V +G E +V V + PGP+ +++ + T SC V+
Sbjct: 18678 LTLVNPAG--EKAVFVNVRVLDTPGPVSDLKVSDVTKT---------SCHVSWAPPENDG 18726
Query: 2273 HAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGAN 2332
+QVT Y + + + +V G E VT G
Sbjct: 18727 GSQVTHY-----IVEKREADRKTWSTVTPEVKKTSFHVTNLVPGNEYYFRVTAVNEYGPG 18781
Query: 2333 LAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWH---KRGGSL-------- 2381
+ P +P+ S+ + L++ + ++ A + W + GG+
Sbjct: 18782 V--PTDVPKPVLASDPLSEPDPPRKLEVTEMT--KNSATLAWLPPLRDGGAKIDGYITSY 18837
Query: 2382 -----PVRHQTHGSLLR---LYQASPADSGEYVCRV-----LGSSVPLEASVLVTIEPAG 2428
P T S+++ L + +Y RV +G S+P EA + +
Sbjct: 18838 REEEQPADRWTEYSVVKDLSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQL 18897
Query: 2429 SVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLP-----ARHQV 2483
P + + + I++ G+ L + V G+ H W K + A H+
Sbjct: 18898 LPPKILMPEQITIKA-------GKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKA 18950
Query: 2484 HGSRLRLLQ-VTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSS 2542
S + +++ VT DSG Y SSGT + V + + ++ S
Sbjct: 18951 DSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDISDIDADACS 19010
Query: 2543 AS----LANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEY 2598
S L +G + N +V RG + + + + R+ ++ P +
Sbjct: 19011 LSWHIPLEDGGSNITNYIVEKCD------VSRGDWVTALASVTKTSCRVGKLIPGQEYIF 19064
Query: 2599 VCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVV---------EGQTLDL 2649
N G E + VPS R+ + + +G + +
Sbjct: 19065 RVRAENRFGISEPLTSPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPII 19124
Query: 2650 NCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASI 2709
++ R+ + + W K +L S EY C ++ LE S
Sbjct: 19125 GYLIERKERNSLLWVKANDTL------------------VRSTEYPCAGL--VEGLEYSF 19164
Query: 2710 VISVSPSAGS--PSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSL 2767
I AGS PS P + R+ + E +D+ ++ + W +
Sbjct: 19165 RIYALNKAGSSPPSKPTEYVTARMPVDPP--GKPEVIDVT-----KSTVSLIWAR----- 19212
Query: 2768 PSHHQTRGSRLRLHHVS----PAD-------SGEYVCRVMGSSGPLEASVLVTIEASGSS 2816
P H GS++ + V P D + + + ++ LE A +
Sbjct: 19213 PKHDG--GSKIIGYFVEACKLPGDKWVRCNTAPHQIPQEEYTATGLEEKAQYQFRAIART 19270
Query: 2817 AVHVPAPG-----------GAPPIRIEPSSSR-----VAEGQTLDLKCVVPGQAHAQVTW 2860
AV++ P PP RI+ S + V G + L V G+ V+W
Sbjct: 19271 AVNISPPSEPSDPVTILAENVPP-RIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSW 19329
Query: 2861 HKRGGNLPARHQVHGPL------LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSS 2914
K G L + + L L V+ DSG+Y+ SSG+ A++ + +
Sbjct: 19330 KKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIKLKVL-DK 19388
Query: 2915 PGPIPAPGLAQPIYIEAS----SSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARH- 2969
PGP PA +Y + + + +G + N +V + ++ W + ++P
Sbjct: 19389 PGP-PASVKINKMYSDRAMLSWEPPLEDGGSEITNYIVDKRETSRPNWAQVSATVPITSC 19447
Query: 2970 ------QTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPV 3023
+ H Q R+ + G+ V T P + Y P
Sbjct: 19448 SVEKLIEGHEYQFRICAENKYGVGDPV----------------FTEPAIAKNPY---DPP 19488
Query: 3024 ISIDPP--SSTVQQGQDASFKCLIHDGAAPIS---LEWKTRNQELEDNVHISPN-GSIIT 3077
DPP S+ + S+K DG +PI+ LE + V+ P +
Sbjct: 19489 GRCDPPVISNITKDHMTVSWKPPADDGGSPITGYLLEKRETQAVNWTKVNRKPIIERTLK 19548
Query: 3078 IVGTRPSNHGTYRCVASNAYG------VAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVT 3131
G + +R A N G +++ PP P+ V+ +V+
Sbjct: 19549 ATGLQEGTEYEFRVTAINKAGPGKPSDASKAAYARDPQYPPGPPAFPK--VYDTTRSSVS 19606
Query: 3132 LE----CVSAGEP----------RSSARWTRISSTPAKLEQRTY---GLMDS-------H 3167
L G P S W R + P L++ + GLM+ +
Sbjct: 19607 LSWGKPAYDGGSPIIGYLVEVKRADSDNWVRCN-LPQNLQKTRFEVTGLMEDTQYQFRVY 19665
Query: 3168 AVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAE-EAELTVEAG 3226
AV +I + PSD + + P ++ A+ L + AG
Sbjct: 19666 AVNKIGYSDPSDVP-----------------DKHYPKDILIPPEGELDADLRKTLILRAG 19708
Query: 3227 HTATLRCSATGSPAPTIHWSK----LRSPLPWQHR-LEGDTLI-IPRVAQQDSGQYICNA 3280
T L G P P I WSK LR + + + DT + V + D+G+YI
Sbjct: 19709 VTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTL 19768
Query: 3281 TSPAGHAEATIILHV---ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGS 3337
+ G E TI++ V PP TV E + A T + + G+P + + + +
Sbjct: 19769 ENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQKRDA 19828
Query: 3338 SLPGRATARNEL--LHFERAAPEDSGRYRCRV--TNKVG------SAEAFAQLLVQGPPG 3387
+T E F A E+ Y RV N+ G + +A GP
Sbjct: 19829 ERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRDAVKASQTPGPVV 19888
Query: 3388 SLPATSIPAGSTPTVQVTPQLE--TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHS 3445
L S+ S P + ++ IG V+F + +W + L +S
Sbjct: 19889 DLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDF-------LTEENKWQRVMKSLSLQYS 19941
Query: 3446 VQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHA 3505
+D L + + T+ A G+ S V+ V ++ + A
Sbjct: 19942 AKD-------LTEGKEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDLCYLA 19994
Query: 3506 VEFECLAL-----GDPKPQVTWSKVGGHLRPGI---VQSGGV---VRIAHVELADAGQYR 3554
E L G P P V+W K L V+S V + + + +DAG+Y
Sbjct: 19995 KENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYT 20054
Query: 3555 CTATNAAGTTQSHVLLLVQALPQI 3578
T N AGT + + + V P I
Sbjct: 20055 ITLKNVAGTKEGTISIKVVGKPGI 20078
Score = 61.6 bits (148), Expect = 2e-08
Identities = 61/264 (23%), Positives = 102/264 (38%), Gaps = 37/264 (14%)
Query: 3349 LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG--------SLPATSIPAGSTP 3400
+L+ + D G YRC+V N G ++A+L V+G ++ +
Sbjct: 31625 ILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMR 31684
Query: 3401 TVQVTPQL------ETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV---- 3450
++ P+ +T +G +V F + + W+K G ++ PG + +
Sbjct: 31685 LLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESD 31744
Query: 3451 -----LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLIN-IRTSVQTVVV-- 3502
L I ++ Y A +G+ A+L + P + +R + ++
Sbjct: 31745 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANA 31804
Query: 3503 ----GHAVEFECLALGDPKPQVTWSKVGGHLRPG----IVQSGGVVRIAHVELA---DAG 3551
G +V FE G P P + W K G L G I+ G H+ D G
Sbjct: 31805 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTG 31864
Query: 3552 QYRCTATNAAGTTQSHVLLLVQAL 3575
YR TATN AG+T L V+ L
Sbjct: 31865 YYRVTATNTAGSTSCQAHLQVERL 31888
Score = 61.2 bits (147), Expect = 2e-08
Identities = 52/218 (23%), Positives = 90/218 (41%), Gaps = 15/218 (6%)
Query: 1862 TLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHG------ 1915
T AP + + V G A F +G P P + W GQ+ + + + G
Sbjct: 2 TTQAPTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRD--GQVISTSTLPGVQISFS 59
Query: 1916 ---GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQ-VHAGR 1971
L +PAV + +Y +A + +GQ + A L V P V ++ V G
Sbjct: 60 DGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGS 119
Query: 1972 TVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITTADAGFYLCVAT 2028
VRL R G+P+ + + ++G + S+ D+ +LLI D+G Y AT
Sbjct: 120 QVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNAT 179
Query: 2029 SPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQ 2066
+ G A + +++V + K S+ ++E +
Sbjct: 180 NSVGRATSTAELLVQGEEEVPAKKTKTIVSTAQISESR 217
Score = 61.2 bits (147), Expect = 2e-08
Identities = 118/609 (19%), Positives = 205/609 (33%), Gaps = 116/609 (19%)
Query: 3110 GPPTVSVLPEGPVWVKV--GKAVTLECVSAGEPRSSARWTRISSTPAKLEQR---TYGLM 3164
G P PV K+ G +V C G P+ W + S P R +Y
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKK-SGVPLTTGYRYKVSYNKQ 1135
Query: 3165 DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE 3224
L IS DAG Y + +N G ++ + + + E+ +
Sbjct: 1136 TGECKLVISMTFADDAGEYTIVVRNKHGETSASASLLEEADYEL-----LMKSQQEMLYQ 1190
Query: 3225 AGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDS---GQYICNAT 3281
TA ++ G AP +S+ ++ E + +I + +D+ Y+ +
Sbjct: 1191 TQVTAFVQEPKVGETAPGFVYSE------YEKEYEKEQALIRKKMAKDTVVVRTYVEDQE 1244
Query: 3282 SPAGHAEATIILHVESPPYATTVPE-----------------------------HASVQA 3312
E +I +E TT+ E + +
Sbjct: 1245 FHISSFEERLIKEIEYRIIKTTLEELLEEDGEEKMAVDISESEAVESGFDSRIKNYRILE 1304
Query: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAA-------PEDSGRYRC 3365
G V C G P W + G + + + L RA+ PED G Y
Sbjct: 1305 GMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTA 1364
Query: 3366 RVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGS-TPTVQVTPQLETKSIGASVEFHCAVP 3424
+N G+A +L V+ PA + A + PT++ ++ + S + +
Sbjct: 1365 FASNIKGNAICSGKLYVE------PAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSPIRMS 1418
Query: 3425 SDRGTQLRWFK---EGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQL 3481
R + R ++ PG R++ D+S
Sbjct: 1419 PARMSPARMSPARMSPARMSPGR-------RLEETDES---------------------- 1449
Query: 3482 VIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK-----VGGHLRPGIVQS 3536
++ L + ++ + G F+ +G P P+ W V + +++
Sbjct: 1450 QLERLYKPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKE 1509
Query: 3537 GGVVRIAHVEL--ADAGQYRCTATNAAGTTQSHVLLLVQALPQISMP------QEVRVPA 3588
G + V +D+G++ A N AG + V+L V+A+ P + V +
Sbjct: 1510 DGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFVEKLKNVNIKE 1569
Query: 3589 GSAAVFPCIASGYPTPDISWSKLDGSLPPDS----RLENN----MLMLPSVRPQDAGTYV 3640
GS A+G P PDI W K + P R+E L + S QD+ Y
Sbjct: 1570 GSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYT 1629
Query: 3641 CTATNRQGK 3649
TA N+ G+
Sbjct: 1630 ATAINKAGR 1638
Score = 61.2 bits (147), Expect = 2e-08
Identities = 199/1031 (19%), Positives = 363/1031 (35%), Gaps = 200/1031 (19%)
Query: 2147 VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA------RHQTHG 2200
V G RP++ V G+T +C + + V W+ +G L R +
Sbjct: 12195 VIGLLRPLK----DVTVTAGETATFDCELSYE-DIPVEWYLKGKKLEPSDKVVPRSEGKV 12249
Query: 2201 SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIES--SSSTVAE 2258
L L V D+GE + A++ V PPV TV E
Sbjct: 12250 HTLTLRDVKLEDAGEV--QLTAKDFKTHANLFVKE---------PPVEFTKPLEDQTVEE 12298
Query: 2259 GQTLDLSCVVAGQAHAQVTWYKRGGSL--PARHQV----RGSRLYIFQASPADAGQYVCR 2312
G T L C V+ + +A+V W+K G + ++++ R +L I +P D Y C
Sbjct: 12299 GATAVLECEVSRE-NAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCD 12357
Query: 2313 ASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQV 2372
A + + S + V L +P+ + QV E + C + + +A+V
Sbjct: 12358 AKD-FKTSCNLNVVPPHVEFL-------RPL----TDLQVREKEMARFECEL-SRENAKV 12404
Query: 2373 TWHKRGGSLPVRHQ----THGS--LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEP 2426
W K G + + + G+ +L + + D EY C V T
Sbjct: 12405 KWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVR------------TART 12452
Query: 2427 AGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL--PARHQV- 2483
+G + L ++ +V+E T+ L C V+ + A+V W+K + R+++
Sbjct: 12453 SGMLTVLEEEAVFTKNLANIEVSETDTIKLVCEVS-KPGAEVIWYKGDEEIIETGRYEIL 12511
Query: 2484 HGSRLRLLQVTPA---DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIES 2540
R R+L + A D+G Y CR+ S + V + +S +
Sbjct: 12512 TEGRKRILVIQNAHLEDAGNYNCRLPSSRTDGKVKVHELAAEFIS-------------KP 12558
Query: 2541 SSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS--RHQIVGSR----LRIPQVTPAD 2594
+ + G + C ++ ++ + W + +L S ++ ++ L + T D
Sbjct: 12559 QNLEILEGEKAEFVCSISKES-FPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQD 12617
Query: 2595 SGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVA 2654
G YV V + ++I ++ I + V E Q + NC V
Sbjct: 12618 MGTYVVMVGAARAAAHLTVIEKLR-------------IVVPLKDTRVKEQQEVVFNCEVN 12664
Query: 2655 RQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDAL--------- 2705
+ A W++ ++ ++ DS +Y+ + + L
Sbjct: 12665 TEG-AKAKWFR------------------NEEAIFDSSKYIILQKDLVYTLRIRDAHLDD 12705
Query: 2706 EASIVISVSPSAGSPSAPGSSMPIRIES-------SSSHVAEGETLDLNCVVPGQAHAQV 2758
+A+ +S++ G +++ + E E +++ C V + + +
Sbjct: 12706 QANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLNVTL 12764
Query: 2759 TWHKRGGSLPSHHQTRGSRLRLHHVSPA------DSGEYVCRVMGSSGPLEASVLVTIEA 2812
W K G +P ++ + H+ D GEY+ E L+ IEA
Sbjct: 12765 KWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAE---LLIIEA 12821
Query: 2813 SGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA--- 2869
H+ V E C + + A V W++ G +
Sbjct: 12822 PTEFVEHL-------------EDQTVTEFDDAVFSCQL-SREKANVKWYRNGREIKEGKK 12867
Query: 2870 -RHQVHGPLLRL--NQVSPADSGEYSCQVTGSSGTLEASVL-VTIEPSSPGP--IPAPGL 2923
+ + G + RL D EY+C V V + +E P + APG
Sbjct: 12868 YKFEKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPG- 12926
Query: 2924 AQPIYIEASSSHVTEGQTLDLNCVV-PGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVS 2982
A +++ + E Q L N VV G H ++ K +L++ +
Sbjct: 12927 ADVVFLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKI------------HRLQICDIK 12974
Query: 2983 PADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFK 3042
P D GEY A E A + P ++ + V+ + P + V
Sbjct: 12975 PRDQGEYRFIAKD---KEARAKLELAAAPKIKTADQ--DLVVDVGKPLTMV--------- 13020
Query: 3043 CLIHDGAAPISLEWKTRNQELEDN-VHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQ 3101
+ +D EW N+ L + + + I+ + + G Y+ V N +G A+
Sbjct: 13021 -VPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIVLQNKHGKAE 13079
Query: 3102 SVVNLSVHGPP 3112
+NL V P
Sbjct: 13080 GFINLKVIDVP 13090
Score = 60.8 bits (146), Expect = 3e-08
Identities = 148/718 (20%), Positives = 258/718 (35%), Gaps = 115/718 (16%)
Query: 2065 GQTLDLNCVVAGSAHAQVTWYRRGGSL---PPHTQVHGSR---LRLPQVSPADSGEYVCR 2118
G + C+V+ S A TW + G ++ P H + + L + V +D+GEY C
Sbjct: 11133 GSSAIFECLVSPST-AITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTCV 11191
Query: 2119 VENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQ 2178
+ G+ K ++ + V PV R ++ V +GQ L L+C +
Sbjct: 11192 LRLGNKEKTSTAKLVV--------EELPV----RFVKTLEEEVTVVKGQPLYLSCEL--N 11237
Query: 2179 AHAQVTWHKRG-------GSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASV 2231
V W K G G + L ++ D+G Y V + LE S
Sbjct: 11238 KERDVVWRKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTV-TVENANNLECSS 11296
Query: 2232 LVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV 2291
V + + + P+R V T +C +A + W+K +PA
Sbjct: 11297 CVKVVEVIRDWLVKPIR----DQHVKPKGTAIFACDIAKDT-PNIKWFKGYDEIPAEPND 11351
Query: 2292 R------GSRLY--IFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPI 2343
+ G+ LY I A P D +Y G +T+ G + L P I
Sbjct: 11352 KTEILRDGNHLYLKIKNAMPEDIAEYAVEI-EGKRYPAKLTL-GEREVELLKPIEDV-TI 11408
Query: 2344 RIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSG 2403
+ S+S AE D +PGQ + + + ++ + L L++ +G
Sbjct: 11409 YEKESASFDAEISEAD----IPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAG 11464
Query: 2404 EYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQ 2463
E + + L +++ + IE +VP VT V E + C++ +
Sbjct: 11465 EVLYQAL-NAITTAILTVKEIELDFAVPLKDVT-----------VPERRQARFECVLTRE 11512
Query: 2464 AHAQVTWHKRGGSLPARHQ---VHGSRLRLLQVTPA---DSGEYVCRVVGSSGTQEASVL 2517
A+ V W K + + + + + +L + + D G Y V G A +
Sbjct: 11513 AN--VIWSKGPDIIKSSDKFDIIADGKKHILVINDSQFDDEGVYTAEVEGKK--TSARLF 11568
Query: 2518 VTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL-PS 2576
VT G+ ++ G T C ++ + H + W+K L S
Sbjct: 11569 VT-----------GIRLKFMSPLEDQTVKEGETATFVCELSHEKMH-VVWFKNDAKLHTS 11616
Query: 2577 RHQIVGS-----RLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPP 2631
R ++ S +L + +VT D + V + + V P
Sbjct: 11617 RTVLISSEGKTHKLEMKEVTLDDISQIKAQVKE------------LSSTAQLKVLEADPY 11664
Query: 2632 IRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSL-PSRHQTHGSH-----LRLHQ 2685
++ T VE + L C V++ + W+K G + PS + + L++ +
Sbjct: 11665 FTVKLHDKTAVEKDEITLKCEVSK--DVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKK 11722
Query: 2686 MSVADSGEYVC-----RANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHV 2738
+ D GEYVC + N+ +EA ++ P G G + IE S V
Sbjct: 11723 ADLKDKGEYVCDCGTDKTKANV-TVEARLIKVEKPLYGVEVFVGETAHFEIELSEPDV 11779
Score = 60.1 bits (144), Expect = 5e-08
Identities = 240/1249 (19%), Positives = 431/1249 (34%), Gaps = 193/1249 (15%)
Query: 1687 IVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQG-SELHFPSVQPSDAGVYI 1745
+V GGS + G P WSRE+G ++ ++L + +DAG YI
Sbjct: 24035 VVRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYI 24094
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQS---------VRPGADVTFICTAK 1796
N S ++ + V + P P + V+E R S + GA V K
Sbjct: 24095 LKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDK 24154
Query: 1797 SKSP--AYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTAT 1854
+S AY V ++ + I R + ++ G G + +D A
Sbjct: 24155 RESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGV----GVPVETVDAVKAA 24210
Query: 1855 LHVQASGTLSAPVVSIHPPQLTVQP----------GQLAEFRCSATGSPTPTLEWTGGPG 1904
G ++ VS L + G + E + P T +W+
Sbjct: 24211 EPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQ------PKGTEKWS---- 24260
Query: 1905 GQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARA----VLHVHGGGGPRVQV 1960
+ A++++ ++ + + Q+ +A++ G+ R V+ P +++
Sbjct: 24261 --IVAESKVCNAVVT--GLSSGQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQPSLKL 24316
Query: 1961 SPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTA-- 2018
+ AG +++ G P I+W K+G L R + AT + I
Sbjct: 24317 PFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNK 24376
Query: 2019 -DAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSS----------PSVTEGQT 2067
D G Y AT+ AGTA + V+VL PV+ + S P+ T G
Sbjct: 24377 DDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQ 24436
Query: 2068 LDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVEN---GSG 2124
+ N +V TW+ ++ T +++ ++ ++ EN S
Sbjct: 24437 IS-NYIVEKRDTTTTTWHMVSATVARTT------IKITKLKTGTEYQFRIFAENRYGKSA 24489
Query: 2125 PKEASITVSVLHGTHSGPSYTP-VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQV 2183
P ++ + GP TP V ++ + V +G T + + + +
Sbjct: 24490 PLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLEQKEKNSI 24549
Query: 2184 TWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGP 2243
W K + T L + + ++VG P + S E V P
Sbjct: 24550 LWVKLNKT--PIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKVS-----ECFVARDP 24602
Query: 2244 I-PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK---RGGSLPARHQVRGSRLYIF 2299
PP R E+ +V + + + W K GGS ++ G YI
Sbjct: 24603 CDPPGRPEA---------------IVITRNNVTLKWKKPAYDGGS-----KITG---YIV 24639
Query: 2300 QASPADAGQYV-CRASNGMEASITVT------------VTGTQGANLAYPAGSTQPIRIE 2346
+ G+++ +N +E TV+ + N + P+ S+ I
Sbjct: 24640 EKKDLPDGRWMKASFTNVLETEFTVSGLVEDQRYEFRVIARNAAGNFSEPSDSSGAITAR 24699
Query: 2347 -----PSSS---------QVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL-------PVRH 2385
P++S V G+T L + G+ V W K G L ++
Sbjct: 24700 DEIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKS 24759
Query: 2386 QTHGSLLRLYQASPADSGEYVCRVLG----SSVPLEASVLVTI-EPAGSVPALGVTPTVR 2440
+ L + D G+Y+ ++ S+P+ VL P G + GVT
Sbjct: 24760 TIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKC 24819
Query: 2441 IESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGE 2500
+ + + +G + ++ + ++++W + +V ++ ++ P + E
Sbjct: 24820 YLAWNPPLQDGGANISHYIIEKRETSRLSWTQ------VSTEVQALNYKVTKLLPGN--E 24871
Query: 2501 YVCRVVG------SSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLA----NGHT 2550
Y+ RV+ + V + G S + +S + A +G T
Sbjct: 24872 YIFRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGT 24931
Query: 2551 LDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRE 2610
++ + + W K ++ + RLR+ +T S E+ N AG E
Sbjct: 24932 EIEGYILEKRDKEGVRWTK-----CNKKTLTDLRLRVTGLTEGHSYEFRVAAENAAGVGE 24986
Query: 2611 TS-------LIVTIQGSGSSHVPSVSPPIRIESS---SPTVVEGQTLDLNCVVARQPQAI 2660
S + G P V+ R S S + +G VV + A
Sbjct: 24987 PSEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAA 25046
Query: 2661 ITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSP 2720
W T + L+ Q +V E N I A+ + V + GS
Sbjct: 25047 DEW---------TTCTPPTGLQGKQFTVTKLKENT-EYNFRICAINSEGVGEPATLPGSV 25096
Query: 2721 SAPGSSMPIRIESSSS-----HVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ--- 2772
A P IE + + TL L + G+ +V W K G L Q
Sbjct: 25097 VAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEV 25156
Query: 2773 -TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHV 2820
+ + L + +V+ DSG Y + +SG A V V + S S+ V++
Sbjct: 25157 TSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNL 25205
Score = 59.7 bits (143), Expect = 6e-08
Identities = 273/1407 (19%), Positives = 480/1407 (34%), Gaps = 253/1407 (17%)
Query: 2352 VAEGQTLDLNCVVPGQSHAQVTWHKRGGSLP----VRHQTHGSL--LRLYQASPADSGEY 2405
V G+T +C + + V W+ +G L V ++ G + L L D+GE
Sbjct: 12207 VTAGETATFDCELSYED-IPVEWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKLEDAGEV 12265
Query: 2406 VCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAH 2465
++ A++ V P L V EG T L C V+ + +
Sbjct: 12266 --QLTAKDFKTHANLFVKEPPVEFTKPL----------EDQTVEEGATAVLECEVSRE-N 12312
Query: 2466 AQVTWHKRGGSLPARHQ---VHGSRLRLLQV---TPADSGEYVCRVVGSSGTQEASVLVT 2519
A+V W K G + + V R+R L + TP D Y C + +V+
Sbjct: 12313 AKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDFKTSCNLNVVPP 12372
Query: 2520 IQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS--R 2577
H + + ++ +A C + S+ + W+K G + +
Sbjct: 12373 --------HVEFLRPLTDLQVREKEMAR-----FECEL-SRENAKVKWFKDGAEIKKGKK 12418
Query: 2578 HQIVGSR----LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIR 2633
+ I+ L I + D EY C V TS ++T+ + +++
Sbjct: 12419 YDIISKGAVRILVINKCLLDDEAEYSCEVRTA----RTSGMLTVLEEEAVFTKNLA---N 12471
Query: 2634 IESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSL--PSRHQ--THGSH--LRLHQMS 2687
IE S E T+ L C V++ P A + WYK + R++ T G L +
Sbjct: 12472 IEVS-----ETDTIKLVCEVSK-PGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAH 12525
Query: 2688 VADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLN 2747
+ D+G Y CR + S + G + + + + EGE +
Sbjct: 12526 LEDAGNYNCR-------------LPSSRTDGKVKVHELAAEFISKPQNLEILEGEKAEFV 12572
Query: 2748 CVVPGQAHAQVTWHKRGGSLPS---HHQTRGSRLRLHHVSPA---DSGEYVCRVMGSSGP 2801
C + ++ V W + +L S + + R+ V A D G YV V +
Sbjct: 12573 CSISKESFP-VQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTYVVMVGAARAA 12631
Query: 2802 LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWH 2861
+V+ + I + +RV E Q + C V + A+ W
Sbjct: 12632 AHLTVIEKLR-----------------IVVPLKDTRVKEQQEVVFNCEVNTEG-AKAKWF 12673
Query: 2862 KRGGNL--PARHQVHGP----LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915
+ + +++ + LR+ D Y+ +T G S I
Sbjct: 12674 RNEEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIVEEED 12733
Query: 2916 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA------RH 2969
I P E +++ C V + + + W K G +P R
Sbjct: 12734 LRIVEP---------LKDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEEVPFDNRVSYRV 12783
Query: 2970 QTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPP 3029
+ L + D GEY+ A + A + P+E +
Sbjct: 12784 DKYKHMLTIKDCGFPDEGEYIVTAGQD---KSVAELLIIEAPTEFVEHL----------E 12830
Query: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN--VHISPNGSI--ITIVGTRPSN 3085
TV + DA F C + A +++W +E+++ +GSI + I R +
Sbjct: 12831 DQTVTEFDDAVFSCQLSREKA--NVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDD 12888
Query: 3086 HGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSAR 3145
Y C + +S L V P + P + G V + + +
Sbjct: 12889 ECEYACGVEDR----KSRARLFVEEIPVEIIRPPQDILEAPGADVVF-LAELNKDKVEVQ 12943
Query: 3146 WTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTG 3205
W R + + ++ LQI KP D G Y +A++ A+ ++
Sbjct: 12944 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLELAA----- 12998
Query: 3206 AMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQ---HRLEGDT 3262
AP+++ + +L V+ G T+ P W K PL + E +
Sbjct: 12999 -----APKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTS 13053
Query: 3263 LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLA 3322
I + D G+Y + G AE I L V P +++ ET +
Sbjct: 13054 FRILEAKKGDKGRYKIVLQNKHGKAEGFINLKVIDVPGPV-----RNLEVTETFDGEVSL 13108
Query: 3323 HGTPPLTFQWSRVGSSLPGR----------ATARNELLHFERAAPEDSG---RYRCRVTN 3369
PLT S++ + R AT R E F + G +R N
Sbjct: 13109 AWEEPLTDGGSKIIGYVVERRDIKRKTWVLATDRAESCEFTVTGLQKGGVEYLFRVSARN 13168
Query: 3370 KVGS---------AEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420
+VG+ EA ++ V GPP ++ T + P+ + GA + +
Sbjct: 13169 RVGTGEPVETDNPVEARSKYDVPGPPLNVTITDVNRFGVSLTWEPPEYDG---GAEITNY 13225
Query: 3421 CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQ 3480
D+ T +RW +D + ++ + + ++ +A G + SA
Sbjct: 13226 VIELRDK-TSIRW-----DTAMTVRAEDLSATVTDVVEGQEYSFRVRAQNRIGVGKPSAA 13279
Query: 3481 LVIQAL------PSVLINIRTSVQT-----------------VVVGHAVEFECLALGDPK 3517
+ PS +N+ +S QT ++G+ +E C +
Sbjct: 13280 TPFVKVADPIERPSPPVNLTSSDQTQSSVQLKWEPPLKDGGSPILGYIIE-RC-----EE 13333
Query: 3518 PQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLL------- 3570
+ W + L P + ++ +E + YR +A N AG + +L
Sbjct: 13334 GKDNWIRCNMKLVPEL-----TYKVTGLEKGNKYLYRVSAENKAGVSDPSEILGPLTADD 13388
Query: 3571 -LVQALPQISMPQ---EVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE---- 3622
V+ +S + EV VP + P ++GYP P +W D L R++
Sbjct: 13389 AFVEPTMDLSAFKDGLEVIVPNPITILVP--STGYPRPTATWCFGDKVLETGDRVKMKTL 13446
Query: 3623 ---NNMLMLPSVRPQDAGTYVCTATNR 3646
+++ PS R D G Y NR
Sbjct: 13447 SAYAELVISPSER-SDKGIYTLKLENR 13472
Score = 59.3 bits (142), Expect = 8e-08
Identities = 59/191 (30%), Positives = 85/191 (44%), Gaps = 25/191 (13%)
Query: 3497 VQTVVV--GHAVEFECLALGDPKPQVTWSKVGGHLR----PGIVQSGGVVR----IAHVE 3546
+Q+VVV G FE G P P+V+W + G + PG+ S R I V
Sbjct: 12 LQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVT 71
Query: 3547 LADAGQYRCTATNAAGTTQSHVLLLVQALPQ----ISMPQEVRVPAGSAAVFPCIASGYP 3602
A++G+Y ATN +G S LLV+A + Q + V GS +G P
Sbjct: 72 KANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIP 131
Query: 3603 TPDISW--------SKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFA 3654
TP + + S LD + + L + L++ P+D+GTY ATN G+ + A
Sbjct: 132 TPVVKFYRDGAEIQSSLDFQISQEGDLYS--LLIAEAYPEDSGTYSVNATNSVGRATSTA 189
Query: 3655 HLQVP-ERVVP 3664
L V E VP
Sbjct: 190 ELLVQGEEEVP 200
Score = 58.9 bits (141), Expect = 1e-07
Identities = 246/1273 (19%), Positives = 424/1273 (33%), Gaps = 205/1273 (16%)
Query: 2497 DSGEYVCRV--VGSSGTQEASVL---VTIQQRLSGSHSQGVAYPVRIESSSASLANGHTL 2551
++ EY R+ + S G E + L V Q+R+ + A ++ AS TL
Sbjct: 25070 ENTEYNFRICAINSEGVGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASA----TL 25125
Query: 2552 DLNCLVASQAPHTITWYKRGGSLPSRHQIVGSR----LRIPQVTPADSGEYVCHVSNGAG 2607
L + + + W K G L R QI + L I VT DSG Y + N +G
Sbjct: 25126 RLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSG 25185
Query: 2608 SRETSLIVTIQGSGSSHVPSVSPPIRIESSS----PTVVEGQTLDLNCVVARQPQAIITW 2663
S+ + V + S S+ V ++ +S + P +++G N +V ++
Sbjct: 25186 SKTAFVNVRVLDSPSAPVNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETT---- 25241
Query: 2664 YKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNID-ALEASIVISVSPSAGSPSA 2722
R + + R+ + S + A+N L A V S P
Sbjct: 25242 --RKAYATITNNCTKTTFRIENLQEGCSYYFRVLASNEYGIGLPAETTEPVKVSE-PPLP 25298
Query: 2723 PGSSMPIRIESSSSHV------AEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGS 2776
PG + + +++ + ++G + VV Q W + Q +
Sbjct: 25299 PGRVTLVDVTRNTATIKWEKPESDGGSKITGYVVEMQTKGSEKW-------STCTQVKTL 25351
Query: 2777 RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPS-- 2834
+ ++ + EYV RV + E S + P A I I+PS
Sbjct: 25352 EATISGLTAGE--EYVFRVAAVN-----------EKGRSDPRQLGVPVIARDIEIKPSVE 25398
Query: 2835 ----SSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH------GPLLRLNQVS 2884
+ V + L + G+ A V W K G L +V+ L + + S
Sbjct: 25399 LPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEAS 25458
Query: 2885 PADSGEYSCQVTGSSG--TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTL 2942
D G Y V+ S+G T+ +++V P PGPI ++ + + +G
Sbjct: 25459 KEDVGTYELCVSNSAGSITVPITIIVLDRPGPPGPIRIDEVSCDSITISWNPPEYDGGCQ 25518
Query: 2943 DLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQE 3002
N +V + TW+ ++ ++ + +V EY R + +
Sbjct: 25519 ISNYIVEKKETTSTTWHIVSQAV--------ARTSIKIVRLTTGSEYQFRVCA-ENRYGK 25569
Query: 3003 ASFTVTVPPSEGSSYRLRSPVISIDPPSS-----TVQQGQDASFKCLIHDGAAPI---SL 3054
+S+ SE S+ P PP + + +++ ++DG + + L
Sbjct: 25570 SSY------SESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHL 25623
Query: 3055 EWKTRNQELEDNVH-ISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVN-------- 3105
E+K R+ L + I + + + G YR A N G+ + +
Sbjct: 25624 EYKERSSILWSKANKILIADTQMKVSGLDEGLMYEYRVYAENIAGIGKCSKSCEPVPARD 25683
Query: 3106 -LSVHGPPTVSVLPEGPV---WVKV----GKAVTLECVSAGEPRSSARWTRISSTPAKLE 3157
G P V+ + V W K G +T V E RW + + T
Sbjct: 25684 PCDPPGQPEVTNITRKSVSLKWSKPHYDGGAKITGYIVERRE-LPDGRWLKCNYTNI--- 25739
Query: 3158 QRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVE----VIVDTGAMAPGAPQ 3213
Q TY +++ + A+NA + + E +IV P
Sbjct: 25740 QETY--------FEVTELTEDQRYEFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMM 25791
Query: 3214 VQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE------GDTLIIPR 3267
+ V+AG + G P P I W+K + + R E L +
Sbjct: 25792 DVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKD 25851
Query: 3268 VAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPP 3327
++D+GQY+ + AG + V P P + G T + L+ G P
Sbjct: 25852 CIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAGPLEIN---GLTAEKCSLSWGRPQ 25908
Query: 3328 LTFQWSRVGSSLPGRATARNELLHFERAAPE--------------DSGRYRCRVT--NKV 3371
G+ + + E H E Y RVT NK
Sbjct: 25909 -----EDGGADIDYYIVEKRETSHLAWTICEGELQMTSCKVTKLLKGNEYIFRVTGVNKY 25963
Query: 3372 GSAE--------AFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAV 3423
G E A V PP SL TS+ S P+ S G S +
Sbjct: 25964 GVGEPLESVAIKALDPFTVPSPPTSLEITSVTKESMTLCWSRPE----SDGGSEISGYII 26019
Query: 3424 PSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI 3483
LRW + + V D ++ L + C+ Y A G + S +
Sbjct: 26020 ERREKNSLRWVRVNKK-----PVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPL 26074
Query: 3484 ------------QALPSVLINIRTSVQTV-----------VVGHAVEFECLALGDPKPQV 3520
+ P ++ + +T++ + G+ VE++
Sbjct: 26075 IRAEDPVFLPSPPSKPKIVDSGKTTITIAWVKPLFDGGAPITGYTVEYK------KSDDT 26128
Query: 3521 TWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISM 3580
W LR G+ A + A++ + ++ + + P +
Sbjct: 26129 DWKTSIQSLRGTEYTISGLTTGAEYVFRVKSVNKVGASDPSDSSDPQIAKEREEEPLFDI 26188
Query: 3581 PQEVR----VPAGSAAVFPCIASGYPTPDISWSKLDGSLPP----DSRLENNMLMLPSVR 3632
E+R V AG++ G P P++ WSK D L D+ L + +
Sbjct: 26189 DSEMRKTLIVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENAN 26248
Query: 3633 PQDAGTYVCTATN 3645
D+G Y T N
Sbjct: 26249 RNDSGKYTLTIQN 26261
Score = 58.9 bits (141), Expect = 1e-07
Identities = 212/1032 (20%), Positives = 364/1032 (35%), Gaps = 196/1032 (18%)
Query: 2740 EGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVM--- 2796
+G + ++ VV Q W K + +HH G R ++ EY RV
Sbjct: 26401 DGGSRIVHYVVEALEKGQKNWVKCAVAKSTHHVVSGLR---------ENSEYFFRVFAEN 26451
Query: 2797 --GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSR---VAEGQTLDLKCVVP 2851
G S P E + V I+ P I ++ S V G L + +
Sbjct: 26452 QAGLSDPRELLLPVLIKEQLEP----------PEIDMKNFPSHTVYVRAGSNLKVDIPIS 26501
Query: 2852 GQAHAQVTWHKRGGNLPARHQVHGPL------LRLNQVSPADSGEYSCQVTGSSGTLEAS 2905
G+ +VT + G L A + + + + L + AD+G Y SSGT +A
Sbjct: 26502 GKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAF 26561
Query: 2906 VLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT----EGQTLDLNCVVPGQAHAQVTWYKR 2961
+ + + PGP P + I E+ + +G + N ++ + + W +
Sbjct: 26562 INIVVL-DRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEV 26620
Query: 2962 GGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQE---ASFTVTVPPSEGSSYR 3018
++ + +++ ++ + ++ +A + G A TV +P Y
Sbjct: 26621 SATVAR------TMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACVTVKLP------YT 26668
Query: 3019 LRSP-----VISIDPPSSTVQQGQDASFKCLIHDGAAPIS--LEWKTRNQELEDNVH--- 3068
P V ++ S TV + S + G+A + LE K RN L +
Sbjct: 26669 TPGPPSTPWVTNVTRESITVGWHEPVS-----NGGSAVVGYHLEMKDRNSILWQKANKLV 26723
Query: 3069 ISPNGSIITIVGTRPSNHGTYRCVASNAYGV------AQSVVNLSVHGPP---------- 3112
I +T + +R A NA GV ++ V+ + PP
Sbjct: 26724 IRTTHFKVTTISAGLIYE--FRVYAENAAGVGKPSHPSEPVLAIDACEPPRNVRITDISK 26781
Query: 3113 -TVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQ 3171
+VS+ + P + G +T V + RWT+ S T Q
Sbjct: 26782 NSVSLSWQQPAF-DGGSKITGYIVERRD-LPDGRWTKASFTNVTETQ-----------FI 26828
Query: 3172 ISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAM-APGAPQVQA--EEAELT-VEAGH 3227
IS + + A+NA+G+ EV+ + + G P + E E+ AG
Sbjct: 26829 ISGLTQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGT 26888
Query: 3228 TATLRCSATGSPAPTIHWSKLRSPLPW------QHRLEGDTLIIPRVAQQDSGQYICNAT 3281
+ LR +G PAPTI W K L ++ + +++I + +SG Y
Sbjct: 26889 SVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLR 26948
Query: 3282 SPAGHAEATIILHVESPPYATTVPEHASVQAGETVQL--------------QCLAHGTPP 3327
+ G A ATI + + P P E + L +
Sbjct: 26949 NAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPADDGGAKITHYIVEKRET 27008
Query: 3328 LTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAE--------AFAQ 3379
WS V L +++ +R R NK G E A
Sbjct: 27009 SRVVWSMVSEHLEECIITTTKIIKGNEYI------FRVRAVNKYGIGEPLESDSVVAKNA 27062
Query: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
+ GPPG T I S V P + G+ + + D+ L WFK +
Sbjct: 27063 FVTPGPPGIPEVTKITKNSMTVVWSRPIADG---GSDISGYFLEKRDK-KSLGWFKVLKE 27118
Query: 3440 LPPGHSVQDGVLRIQNLDQSCQGTY-ICQAH----GPWGKAQ---ASAQLVIQALPSVLI 3491
+++D ++ L ++ Y +C + GP+ + +A + P I
Sbjct: 27119 -----TIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPPAKI 27173
Query: 3492 NIRTSVQTVVVGHAVEFECLALGDPKPQVT-WSKVGGH---LRPG------IVQSGGVVR 3541
I S ++ + LG KP S V G+ +R G V + G VR
Sbjct: 27174 RIADSTKS----------SITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVR 27223
Query: 3542 -----IAHVELADAGQYRCTATNAAGTTQ----------SHVLLLVQALPQISMPQEVRV 3586
+++++ +R +A N AG + +L + +++ V
Sbjct: 27224 TTEYVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALRTSVIA 27283
Query: 3587 PAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR--LEN----NMLMLPSVRPQDAGTYV 3640
AG G P P ++W K + +L D+R +EN ++L +P V D G Y+
Sbjct: 27284 KAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYI 27343
Query: 3641 CTATNRQGKVKA 3652
T N G+ K+
Sbjct: 27344 LTIENGVGEPKS 27355
Score = 58.9 bits (141), Expect = 1e-07
Identities = 66/268 (24%), Positives = 90/268 (33%), Gaps = 51/268 (19%)
Query: 3165 DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIV---------------------- 3202
D A+L + D GTY C N G E+ V
Sbjct: 31621 DGVAILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRT 31680
Query: 3203 DTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLP-----WQHR 3257
DT + P+ T G + T P P + W K + ++
Sbjct: 31681 DTMRLLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYT 31740
Query: 3258 LEGDT----LIIPRVAQQDSGQYICNATSPAGH----AEATIILHVESPPYATTVPE--- 3306
E D L I V D +Y A + G A+ T+ LH PP +T+
Sbjct: 31741 FESDKGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLH--PPPTDSTLRPMFK 31798
Query: 3307 ----HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL---PGRATARNEL----LHFERA 3355
+A Q G++V + G PP T +W + G L P L LH
Sbjct: 31799 RLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDT 31858
Query: 3356 APEDSGRYRCRVTNKVGSAEAFAQLLVQ 3383
PED+G YR TN GS A L V+
Sbjct: 31859 LPEDTGYYRVTATNTAGSTSCQAHLQVE 31886
Score = 58.5 bits (140), Expect = 1e-07
Identities = 80/323 (24%), Positives = 126/323 (39%), Gaps = 37/323 (11%)
Query: 1970 GRTVRLYCRAAGVPSATITWRKEG-----GSLPPQARSERTDIATLLIPAITTADAGFYL 2024
G T +G P ++W ++G +LP S A L IPA+T A++G Y
Sbjct: 20 GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79
Query: 2025 CVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTW 2084
AT+ +G A + +++V ++ +PP S +V +G + L V G V +
Sbjct: 80 LKATNGSGQATSTAELLV--KAETAPPNFVQRLQSMTVRQGSQVRLQVRVTGIPTPVVKF 137
Query: 2085 YRRGGSLPPHTQVHGSR------LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGT 2138
YR G + S+ L + + P DSG Y N G + S ++ G
Sbjct: 138 YRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG-RATSTAELLVQGE 196
Query: 2139 HSGPS-------YTPVPGSTRPIRIEPS-SSHVAEGQTLDLNCVVPGQAHAQVTWHKRGG 2190
P+ T +R RIE +H + V+ G A Q+ HK
Sbjct: 197 EEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVEMVIDGAAGQQLP-HKTPP 255
Query: 2191 SLP----ARHQTHGSLLRLHQVTPADSGEYVCH----VVGTSGPLEASV-LVTIEASVIP 2241
+P +R T S+ Q+ S + H V P + V V+ A +
Sbjct: 256 RIPPKPKSRSPTPPSIAAKAQLARQQSPSPIRHSPSPVRHVRAPTPSPVRSVSPAARIST 315
Query: 2242 GPIPPVRI-----ESSSSTVAEG 2259
PI VR ++ +STVA G
Sbjct: 316 SPIRSVRSPLLMRKTQASTVATG 338
Score = 58.5 bits (140), Expect = 1e-07
Identities = 146/671 (21%), Positives = 237/671 (35%), Gaps = 95/671 (14%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRH----QGSELHFPSVQPSDAGVYIC 1746
G S C VS S W + DG + + R + +LH VQ SDAG Y C
Sbjct: 11133 GSSAIFECLVSPSTA-ITTWMK-DGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTC 11190
Query: 1747 TCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVW 1806
R ++ TS A+L+V E P + + EE +V G + C + +VW
Sbjct: 11191 VLRLGNKEKTSTAKLVVEELPVRFVKTLEEE---VTVVKGQPLYLSCELNKER---DVVW 11244
Query: 1807 TR------LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA- 1859
+ G++ + LTI + +DAGTY T N ++ + V+
Sbjct: 11245 RKDGKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVENANNLECSSCVKVVEVI 11304
Query: 1860 SGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILR 1919
L P+ H V+P A F C TP ++W G ++PA+ ILR
Sbjct: 11305 RDWLVKPIRDQH-----VKPKGTAIFACD-IAKDTPNIKWFKG-YDEIPAEPNDKTEILR 11357
Query: 1920 LPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPER--TQVHAGRTVRLYC 1977
D + ++ + +A + + G P ER + V +Y
Sbjct: 11358 -------DGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGEREVELLKPIEDVTIYE 11410
Query: 1978 RAAGVPSATIT-------WRKEGGSLPPQARSE---RTDIATLLIPAITTADAGFYLCVA 2027
+ + A I+ W+ +G L P E L + + AG L A
Sbjct: 11411 KESASFDAEISEADIPGQWKLKGELLRPSPTCEIKAEGGKRFLTLHKVKLDQAGEVLYQA 11470
Query: 2028 TSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRR 2087
+ TA ++ + L + + +V E + CV+ + A V W
Sbjct: 11471 LNAITTAILTVKEIELDFA--------VPLKDVTVPERRQARFECVL--TREANVIW--- 11517
Query: 2088 GGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPV 2147
S P + + AD +++ + + E T V S + V
Sbjct: 11518 --SKGPDIIKSSDKFDI----IADGKKHILVINDSQFDDEGVYTAEVEGKKTSARLF--V 11569
Query: 2148 PGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL--------PARHQTH 2199
G V EG+T C + V W K L + +TH
Sbjct: 11570 TGIRLKFMSPLEDQTVKEGETATFVCEL-SHEKMHVVWFKNDAKLHTSRTVLISSEGKTH 11628
Query: 2200 GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEG 2259
L + +VT D + V S + VL EA P ++ T E
Sbjct: 11629 --KLEMKEVTLDDISQIKAQVKELSSTAQLKVL---EAD------PYFTVKLHDKTAVEK 11677
Query: 2260 QTLDLSCVVAGQAHAQVTWYKRGGSL--PARHQVRGSR----LYIFQASPADAGQYVCR- 2312
+ L C V+ V W+K G + ++ ++ L I +A D G+YVC
Sbjct: 11678 DEITLKCEVS--KDVPVKWFKDGEEIVPSPKYSIKADGLRRILKIKKADLKDKGEYVCDC 11735
Query: 2313 ASNGMEASITV 2323
++ +A++TV
Sbjct: 11736 GTDKTKANVTV 11746
Score = 58.5 bits (140), Expect = 1e-07
Identities = 223/1177 (18%), Positives = 422/1177 (35%), Gaps = 198/1177 (16%)
Query: 2553 LNCLVASQAPHTITWYKRGGSL-PSRHQIVGS-----RLRIPQVTPADSGEYVCHVSNGA 2606
L C + S+A + W+K G + PS++ ++ + L + + +D G+Y C
Sbjct: 12037 LQCEI-SKADAPVKWFKDGKEIKPSKNAVIKADGKKRMLILKKALKSDIGQYTCD----C 12091
Query: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKR 2666
G+ +TS + I+ + V P +E V+E +T ++ + W +
Sbjct: 12092 GTDKTSGKLDIE---DREIKLVRPLHSVE-----VMETETARFETEIS-EDDIHANWKLK 12142
Query: 2667 GGSLPSRHQTHGSHLRLHQMSVADSGE------YVCRANNN--IDALEASIVISVSPSAG 2718
G +L L+ + + G+ + CR + +D +A+ V S +
Sbjct: 12143 GEAL----------LQTPDCEIKEEGKIHSLVLHNCRLDQTGGVD-FQAANVKSSAHLRV 12191
Query: 2719 SPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSL-PSHHQTRGSR 2777
P G P++ + V GET +C + + V W+ +G L PS S
Sbjct: 12192 KPRVIGLLRPLKDVT----VTAGETATFDCELSYE-DIPVEWYLKGKKLEPSDKVVPRSE 12246
Query: 2778 LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEP--SS 2835
++H ++ D LE + V + A H PP+
Sbjct: 12247 GKVHTLTLRDV------------KLEDAGEVQLTAKDFKT-HANLFVKEPPVEFTKPLED 12293
Query: 2836 SRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL--PARHQVHGP----LLRLNQVSPADSG 2889
V EG T L+C V + +A+V W K G + ++++ L ++ +P D
Sbjct: 12294 QTVEEGATAVLECEV-SRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIK 12352
Query: 2890 EYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVP 2949
Y+C + +V+ P +P+ + V E + C +
Sbjct: 12353 TYTCDAKDFKTSCNLNVVP----------PHVEFLRPL----TDLQVREKEMARFECEL- 12397
Query: 2950 GQAHAQVTWYKRGGSLPARHQ---THGSQLRLHLVSPA---DSGEYVC--RAASGPGP-- 2999
+ +A+V W+K G + + +R+ +++ D EY C R A G
Sbjct: 12398 SRENAKVKWFKDGAEIKKGKKYDIISKGAVRILVINKCLLDDEAEYSCEVRTARTSGMLT 12457
Query: 3000 --EQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTV--QQGQDASFKCLIHDGAAPISLE 3055
E+EA FT + E S V + P + V +G + +I G I E
Sbjct: 12458 VLEEEAVFTKNLANIEVSETDTIKLVCEVSKPGAEVIWYKGDEE----IIETGRYEILTE 12513
Query: 3056 WKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVS 3115
+ R I+ I + G Y C ++ ++ + VH
Sbjct: 12514 GRKR---------------ILVIQNAHLEDAGNYNCRLPSS----RTDGKVKVHELAAEF 12554
Query: 3116 VLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSA 3175
+ + + G+ C S + +W R T ++ VL + A
Sbjct: 12555 ISKPQNLEILEGEKAEFVC-SISKESFPVQWKRDDKTLESGDKYDVIADGKKRVLVVKDA 12613
Query: 3176 KPSDAGTYVCLAQNALGTAQ----KQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATL 3231
D GTYV + A A +++ ++V Q E+ E
Sbjct: 12614 TLQDMGTYVVMVGAARAAAHLTVIEKLRIVVPLKDTRVKEQQEVVFNCEVNTEGAKAKWF 12673
Query: 3232 RCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGH---AE 3288
R + + + L+ L + R+ L D Y + T+ G +
Sbjct: 12674 RNEE--AIFDSSKYIILQKDLVYTLRIRDAHL-------DDQANYNVSLTNHRGENVKSA 12724
Query: 3289 ATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG------R 3342
A +I+ E + + +++ ++V C + +T +W++ G +P R
Sbjct: 12725 ANLIVEEEDLRIVEPLKDIETMEK-KSVTFWCKVNRLN-VTLKWTKNGEEVPFDNRVSYR 12782
Query: 3343 ATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTV 3402
+L + D G Y G ++ A+LL+ P
Sbjct: 12783 VDKYKHMLTIKDCGFPDEGEYIVTA----GQDKSVAELLIIEAP---------------T 12823
Query: 3403 QVTPQLETKSIGA--SVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ---DG-----VLR 3452
+ LE +++ F C + ++ ++W++ G ++ G + DG +++
Sbjct: 12824 EFVEHLEDQTVTEFDDAVFSCQLSREKAN-VKWYRNGREIKEGKKYKFEKDGSIHRLIIK 12882
Query: 3453 IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLA 3512
LD C+ Y C ++ A+L ++ +P + I Q ++ + LA
Sbjct: 12883 DCRLDDECE--YACGVED----RKSRARLFVEEIP---VEIIRPPQDILEAPGADVVFLA 12933
Query: 3513 -LGDPKPQVTWSKVGGHLRPG----IVQSGGVVR--IAHVELADAGQYRCTATNAAGTTQ 3565
L K +V W + + G ++ G + R I ++ D G+YR A + +
Sbjct: 12934 ELNKDKVEVQWLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDK----E 12989
Query: 3566 SHVLLLVQALPQI-SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPP---DSRL 3621
+ L + A P+I + Q++ V G YP + W K + L D+
Sbjct: 12990 ARAKLELAAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTA 13049
Query: 3622 ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
E + + D G Y N+ GK + F +L+V
Sbjct: 13050 EQTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKV 13086
Score = 57.8 bits (138), Expect = 2e-07
Identities = 140/666 (21%), Positives = 230/666 (34%), Gaps = 75/666 (11%)
Query: 2824 GGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQV------HGPL 2877
G AP IR E G+ L C + G+ + W++ G L +
Sbjct: 30530 GEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT 30589
Query: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
L + D G Y+C T G +E S + ++ ++P P L + Y
Sbjct: 30590 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQ-ATPQFHPGYPLKEKYYGAV------ 30642
Query: 2938 EGQTLDLNCVVPGQAHAQVTWY------KRGGSLPARHQTHGSQLRLHLVS-PADSGEYV 2990
G TL L+ + G+ +TW+ + ++ + H + L + V +G+Y
Sbjct: 30643 -GSTLRLHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYK 30701
Query: 2991 CRAASGPGPEQEASFTVTVP--------PSEGSSYRLRSPVISIDPPSSTVQQGQDASFK 3042
+ ++ G +A V + P + S VIS PP+ G
Sbjct: 30702 VQLSNVFGTV-DAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPAD---DGGSWITN 30757
Query: 3043 CLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITI-VGTRPSNHGTY-RCVASNAYGVA 3100
++ A EW+ +S S+ T + N G Y R A N +G++
Sbjct: 30758 YVVEKCEAKEGAEWQL----------VSSAISVTTCRIVNLTENAGYYFRVSAQNTFGIS 30807
Query: 3101 QSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRT 3160
+ SV + P P + CV A +P +S +I + + ++
Sbjct: 30808 DPLEVSSVVIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPASDGGAKIRNYYLEKREKK 30867
Query: 3161 YGLMDSHAVLQIS----SAKPSDAGT---YVCLAQNALGTAQ--KQVEVIVDTGAMAPGA 3211
S +I S K G + +N G ++ + E I + A
Sbjct: 30868 QNKWISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQA 30927
Query: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL---PWQHRLEG-----DTL 3263
P + E L V ATL C TG P P + W + + ++R++ L
Sbjct: 30928 PHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQL 30987
Query: 3264 IIPRVAQQDSGQYICNATSPAGHAEATIILHVESPP---YATTVPEHASVQA--GETVQL 3318
II V D+ Y AT+ G T L VE P T+ +V A GE V +
Sbjct: 30988 IIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSI 31047
Query: 3319 QCLAHGTPPLTFQWSRVGSSLPGR-------ATARNELLHFERAAPEDSGRYRCRVTNKV 3371
+ G P W + + + L+ +D+G Y N+
Sbjct: 31048 KIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCAKNRF 31107
Query: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQL 3431
G + +L V P + S +V +T E S G S + V T
Sbjct: 31108 GIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLT-WTEPASDGGSKITNYIVEKCATTAE 31166
Query: 3432 RWFKEG 3437
RW + G
Sbjct: 31167 RWLRVG 31172
Score = 57.0 bits (136), Expect = 4e-07
Identities = 168/806 (20%), Positives = 283/806 (35%), Gaps = 120/806 (14%)
Query: 2939 GQTLDLNCVVPGQAHAQVTWYKRGGSLPAR------HQTHGSQLRLHLVSPADSGEYVCR 2992
G T+ L V G+ ++TW K +L R + LR V+ D+G+Y+
Sbjct: 19708 GVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILT 19767
Query: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPI 3052
+ G ++E + V V + G + IS D T + I DG +PI
Sbjct: 19768 LENSCG-KKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPP--------IIDGGSPI 19818
Query: 3053 SLEWKTRNQELE----DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV 3108
+ + + ++ E V + + + +R A N YG+
Sbjct: 19819 -INYVVQKRDAERKSWSTVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPG---ET 19874
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKL--EQRTYGLMDS 3166
S P V +KV C + S +RI E+ + +
Sbjct: 19875 RDAVKASQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMK 19934
Query: 3167 HAVLQISSAKPSDAGTYVCLA----QNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELT 3222
LQ S+ ++ Y +N GT ++ V+ +AP +
Sbjct: 19935 SLSLQYSAKDLTEGKEYTFRVSAENENGEGTPS-EITVVARDDVVAPDLDLKGLPDLCYL 19993
Query: 3223 VEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGD------TLIIPRVAQQDSGQY 3276
+ L+ G PAP++ W K PL R+ + TLI+ + D+G+Y
Sbjct: 19994 AKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKY 20053
Query: 3277 ICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVG 3336
+ AG E TI + V P T P E + L+ PP S +
Sbjct: 20054 TITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTAEAMTLK----WAPPKDDGGSEIT 20109
Query: 3337 S-SLPGRATARNELLHFERAAPEDSGR-----------YRCRVTNKVGSAEAFAQ--LLV 3382
+ L R + N+ + A + + R +R NK G E ++
Sbjct: 20110 NYILEKRDSVNNKWVTCASAVQKTTFRVTRLHEGMEYTFRVSAENKYGVGEGLKSEPIVA 20169
Query: 3383 QGP---PGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
+ P P + P +I +V +T K+ G+ + + +R + L +K +
Sbjct: 20170 RHPFDVPDAPPPPNIVDVRHDSVSLTWTDPKKTGGSPITGYHLEFKERNSLL--WKRANK 20227
Query: 3440 LPPGHSVQDGVLRIQNLDQSCQGTYICQA--HGPWGKAQASAQLVI-------QALPSVL 3490
P ++ ++ L + + + A GK ++ V+ P V+
Sbjct: 20228 TP----IRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPSLPSEPVVALDPIDPPGKPEVI 20283
Query: 3491 INIRTSVQTV-----------VVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGV 3539
R SV + + G+ VE L P +W K P
Sbjct: 20284 NITRNSVTLIWTEPKYDGGHKLTGYIVEKRDL------PSKSWMKANHVNVPECA----- 20332
Query: 3540 VRIAHVELADAGQY--RCTATNAAG-------TTQSHVLLLVQALPQISMPQEVR----V 3586
+L + G+Y R A N AG +T++ + P I + ++ +
Sbjct: 20333 --FTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTI 20390
Query: 3587 PAGSAAVFPCIA-SGYPTPDISWSKLDGSLPPD------SRLENNMLMLPSVRPQDAGTY 3639
AG V I+ G P P SWSK + P S ++ML + +DAG Y
Sbjct: 20391 KAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEY 20450
Query: 3640 VCTATNRQG-KVKAFAHLQVPERVVP 3664
TATN G KV+ H++V VP
Sbjct: 20451 TITATNPFGTKVE---HVKVTVLDVP 20473
Score = 57.0 bits (136), Expect = 4e-07
Identities = 108/518 (20%), Positives = 174/518 (33%), Gaps = 93/518 (17%)
Query: 3208 APGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK-------LRSPLPWQHRLEG 3260
AP A + + V AG T L G P P + WSK + + + ++
Sbjct: 24704 APNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQK 24763
Query: 3261 DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQC 3320
TL++ + D GQYI ++ G I + V P PE G T + +C
Sbjct: 24764 TTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRP---GPPEGPLKVTGVTAE-KC 24819
Query: 3321 LAHGTPPL------------------TFQWSRVGSSLPGRATARNELLHFERAAPEDSGR 3362
PPL W++V + + +LL P +
Sbjct: 24820 YLAWNPPLQDGGANISHYIIEKRETSRLSWTQVSTEVQALNYKVTKLL------PGNEYI 24873
Query: 3363 YRCRVTNKVGSAEAFAQLLVQG-----PPGSLPATSIPAGSTPTVQVTPQLETKSIGASV 3417
+R NK G E V PPG + A + ++ VT G +
Sbjct: 24874 FRVMAVNKYGIGEPLESGPVTACNPYKPPGPPSTPEVSAITKDSMVVTWARPVDDGGTEI 24933
Query: 3418 EFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQA 3477
E + D+ +RW K + ++ D LR+ L + + A G +
Sbjct: 24934 EGYILEKRDK-EGVRWTKCNKK-----TLTDLRLRVTGLTEGHSYEFRVAAENAAGVGEP 24987
Query: 3478 SAQLVI------------QALPSVLINIRTSVQTV-----------VVGHAVEFECLALG 3514
S V + P V R+SV V G+ VE + A
Sbjct: 24988 SEPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEVKEAAAD 25047
Query: 3515 DPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQA 3574
+ W+ P G + ++ +R A N+ G + L
Sbjct: 25048 E------WTT----CTPPTGLQGKQFTVTKLKENTEYNFRICAINSEGVGEPATLPGSVV 25097
Query: 3575 LPQISMPQEVRVPAGSAAVFPCIAS----------GYPTPDISWSKLDGSLPPDSRLE-- 3622
+ P E+ + A V AS G P P++ W K +G L +++E
Sbjct: 25098 AQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVT 25157
Query: 3623 --NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
ML++ +V D+G Y T N G AF +++V
Sbjct: 25158 SSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRV 25195
Score = 56.6 bits (135), Expect = 5e-07
Identities = 173/842 (20%), Positives = 282/842 (33%), Gaps = 158/842 (18%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLL-IPAITTADAGFYLC 2025
+ G T+RL GVP +TW+KE P +AR + T + + L I D G Y
Sbjct: 17230 IKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSL 17289
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWY 2085
+PAG+ ++V+VL D PP + L+++ + S + +TW
Sbjct: 17290 TVENPAGSKTVSVKVLVL---DKPGPP-------------RDLEVSEIRKDSCY--LTWK 17331
Query: 2086 RR---GGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGP 2142
GGS+ + V + Q SP + + K + L +
Sbjct: 17332 EPLDDGGSVITNYVVERRDVASAQWSPLSATSK----KKSHFAKHLNEGNQYLFRVAAEN 17387
Query: 2143 SYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK--RGGSLP-----AR 2195
Y P P I+ G DL+ V + + W+K R G P
Sbjct: 17388 QYGRGPFVETPKPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVE 17447
Query: 2196 HQTHGSL--LRLHQVTPADSGEYVCHVVGTS-----------------GPLEASVLVTIE 2236
+Q G+ ++ VT + C V G G + ++ + +
Sbjct: 17448 YQEEGTQDWIKFKTVTNLE-----CVVTGLQQGKTYRFRVKAENIVGLGLPDTTIPIECQ 17502
Query: 2237 ASVIPGPIPPVRIESS---SSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR- 2292
++P P V ++ V G T+ ++ G W G +
Sbjct: 17503 EKLVP---PSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTV 17559
Query: 2293 -----GSRLYIFQASPADAGQY---VCRASNGMEASITVTVTGTQGANLAYPAGSTQPIR 2344
S L I D G+Y V A+ ++ +TV G P G +
Sbjct: 17560 ETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGP----PTGPINILD 17615
Query: 2345 IEPSSSQVA------EGQTLDLNCVVPGQSHAQVTWH--KRGGS---LPVRHQTHGSLLR 2393
+ P ++ +G + +N +V Q + TW G S L + H G
Sbjct: 17616 VTPEHMTISWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIPHLQKGC--- 17672
Query: 2394 LYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQT 2453
EYV RV + G P L TPTV S G+
Sbjct: 17673 ----------EYVFRVRAEN------------KIGVGPPLDSTPTVAKHKFSPPSPPGKP 17710
Query: 2454 LDLNCLVAGQAHAQVTWHKRGGSLPA------RHQVHGSRLRLLQVTPADSGEYVCRVVG 2507
+ + + A T K G P R +V G +R+ + AD RV G
Sbjct: 17711 V-VTDITENAATVSWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIAD---LKFRVTG 17766
Query: 2508 --SSGTQEASV----LVTIQQRLSGSHSQGVAYPVR---------IESSSAS-------- 2544
T E V L + + S P++ ++ S
Sbjct: 17767 LYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTK 17826
Query: 2545 -LANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVS 2603
L++G + L +V Q P T W + + I R+P + + + +
Sbjct: 17827 PLSDGGSPILGYVVECQKPGTAQWNR----INKDELIRQCAFRVPGLIEGNEYRFRIKAA 17882
Query: 2604 NGAGSRET-SLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIIT 2662
N G E L ++ H P V + TV GQT+ + V +P+ IT
Sbjct: 17883 NIVGEGEPRELAESVIAKDILHPPEVELDVTCRDVI-TVRVGQTIRILARVKGRPEPDIT 17941
Query: 2663 WYKRGGSLPSRHQTH------GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPS 2716
W K G L + L++ + AD G+Y+ A N+ + S +++V
Sbjct: 17942 WTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDR 18001
Query: 2717 AG 2718
G
Sbjct: 18002 PG 18003
Score = 56.6 bits (135), Expect = 5e-07
Identities = 175/833 (21%), Positives = 295/833 (35%), Gaps = 129/833 (15%)
Query: 2565 ITWYKRGGSLPSRHQIVGSR----LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGS 2620
+TW K +L +R I + L IP+ D+G++V + N AG + S
Sbjct: 20808 VTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKK----------S 20857
Query: 2621 GSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVAR-QPQAIITWYKRGGSLPSRHQTHGS 2679
G +V + P + + PT + ++ L+ + + IT Y +R +
Sbjct: 20858 GFVNVRVLDTPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTA 20917
Query: 2680 HLRLHQMSVADSG-----EYVCR--ANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIE 2732
+ H+ + +G EY R A N E + ++ +PS P S + I
Sbjct: 20918 TTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDIT 20977
Query: 2733 SSSSHVA------EGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPA 2786
S+ +A +G + V+ Q W H T L +
Sbjct: 20978 KSTVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWT---------HITTVKGLECVVRNLT 21028
Query: 2787 DSGEYVCRVM-----GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEG 2841
+ EY +VM G S P E+ ++ E + + + I G
Sbjct: 21029 EGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLRG--------IYQKLVIAKAG 21080
Query: 2842 QTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH------GPLLRLNQVSPADSGEYSCQV 2895
+ ++ V G+ VTW K L +V+ +L +N+ +DSG Y
Sbjct: 21081 DNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTA 21140
Query: 2896 TGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT--------EGQTLDLNCV 2947
G E ++TI+ IP P + E SS VT +G N V
Sbjct: 21141 RNIVG--EVGDVITIQVHD---IPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYV 21195
Query: 2948 VPGQAHAQVTWYKRGGSL-----PARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQE 3002
V + TW + ++ A T G + + + + R GPG
Sbjct: 21196 VEMRQTDSTTWVELATTVIRTTYKATRLTTGLEYQFRVKAQN-------RYGVGPGITSA 21248
Query: 3003 ---ASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPI---SLEW 3056
A++ VP G+ V ++ S T+ + S DG +PI +E
Sbjct: 21249 CIVANYPFKVPGPPGTPQ-----VTAVTKDSMTISWHEPLS------DGGSPILGYHVER 21297
Query: 3057 KTRNQELEDNVHIS-PNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVS 3115
K RN L V + G+I G +R +A N G ++ S P ++
Sbjct: 21298 KERNGILWQTVSKALVPGNIFKSSGLTDGIAYEFRVIAENMAGKSKP----SKPSEPMLA 21353
Query: 3116 VLPEGPVWVKVGKAVTLECVSA--GEPRSSARWTRISSTPAK--------LEQRTYGLMD 3165
+ P P V +T V+ +P + + S K L+ +++
Sbjct: 21354 LDPIDPPGKPVPLNITRHTVTLKWAKPEYTGGFKITSYIVEKRDLPNGRWLKANFSNILE 21413
Query: 3166 SHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVI-VDTGAMAPGAPQVQAE---EAEL 3221
+ +S A + +A+NA G E T AP+++ + + +
Sbjct: 21414 NE--FTVSGLTEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPKIKVDVKFKDTV 21471
Query: 3222 TVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE------GDTLIIPRVAQQDSGQ 3275
++AG L +G P PT+ WSK L +LE L+ ++DSG
Sbjct: 21472 ILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGA 21531
Query: 3276 YICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPL 3328
Y AT+P G A+ + V P P + E +C+ PPL
Sbjct: 21532 YTLTATNPGGFAKHIFNVKVLDRP----GPPEGPLAVTEVTSEKCVLSWFPPL 21580
Score = 55.5 bits (132), Expect = 1e-06
Identities = 57/243 (23%), Positives = 84/243 (34%), Gaps = 62/243 (25%)
Query: 3475 AQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI- 3533
A+ A + I P L++ +V TV+ G +V EC G P P VTW + + I
Sbjct: 930 ARVPAPVEIPVTPPTLVSGLKNV-TVIEGESVTLECHISGYPSPTVTWYREDYQIESSID 988
Query: 3534 ----VQSG-GVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ----------- 3577
QSG + I D+G++ C+A N AGT + L VQ +
Sbjct: 989 FQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAVTEK 1048
Query: 3578 ------------------------------------ISMPQEVRVPAGSAAVFPCIASGY 3601
I+ P ++ G + VF C G
Sbjct: 1049 FTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQVGGN 1108
Query: 3602 PTPDISWSKLDGSLPPDSRLENN--------MLMLPSVRPQDAGTYVCTATNRQGKVKAF 3653
P P + W K L R + + L++ DAG Y N+ G+ A
Sbjct: 1109 PKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSAS 1168
Query: 3654 AHL 3656
A L
Sbjct: 1169 ASL 1171
Score = 55.5 bits (132), Expect = 1e-06
Identities = 101/468 (21%), Positives = 164/468 (35%), Gaps = 59/468 (12%)
Query: 3146 WTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQ--VEVIVD 3203
W R + TP + Y +++ + + LA NA G + E ++
Sbjct: 17159 WRRANHTPESCPETKY---------KVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLV 17209
Query: 3204 TGAMAPGAPQVQAEEA-ELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE--- 3259
+ P + A A E ++ G T L G P P + W K P + R++
Sbjct: 17210 KDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTP 17269
Query: 3260 -GDTLIIPRVAQQDSGQYICNATSPAGHAEATI---ILHVESPPYATTVPE--------- 3306
G L I A +D G Y +PAG ++ +L PP V E
Sbjct: 17270 VGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDSCYLT 17329
Query: 3307 -HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLH-----FERAAPEDS 3360
+ G +V + + QWS + ++ ++ L F AA
Sbjct: 17330 WKEPLDDGGSVITNYVVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQY 17389
Query: 3361 GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420
GR T K +A L GPP L + V P + G+ + +
Sbjct: 17390 GRGPFVETPK--PIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPD---RDGGSPITGY 17444
Query: 3421 CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQ 3480
+ GTQ W K +V + + L Q + +A G
Sbjct: 17445 LVEYQEEGTQ-DWIK-------FKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTT 17496
Query: 3481 LVIQAL-----PSVLINIRTSVQTVV-VGHAVEFECLALGDPKPQVTWSKVGGHLRPG-- 3532
+ I+ PSV ++++ VV G V F + G P P W+ G ++
Sbjct: 17497 IPIECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEH 17556
Query: 3533 -IVQS---GGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALP 3576
V++ V+ I + D G+Y+ T +NAAG+ V L V +P
Sbjct: 17557 YTVETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVP 17604
Score = 55.5 bits (132), Expect = 1e-06
Identities = 232/1219 (19%), Positives = 419/1219 (34%), Gaps = 185/1219 (15%)
Query: 2594 DSGEYVCHVSNGAGSRETSLIVTIQG-----SGSSHVPSVSPPIRIESSSPTVVEGQTLD 2648
DSG Y + N AG + S+ V + G +G V SVS + S G T
Sbjct: 28714 DSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSAESCVLSWGEPKDGGGTEI 28773
Query: 2649 LNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNN-----ID 2703
N +V ++ W S+ R Q +HL + EY R ++
Sbjct: 28774 TNYIVEKRESGTTAWQLVNSSV-KRTQIKVTHLTKYM-------EYSFRVSSENRFGVSK 28825
Query: 2704 ALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA------EGETLDLNCVVPGQAHAQ 2757
LE++ +I+ P PSAP + +++ + +G + + V +
Sbjct: 28826 PLESAPIIAEHPFV-PPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIGYWVEKKERNT 28884
Query: 2758 VTWHKRGG--SLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGS 2815
+ W K L +++ G L + Y G S EAS + +
Sbjct: 28885 ILWVKENKVPCLECNYKVTGLVEGLEY----QFRTYALNAAGVSKASEASRPIMAQNP-- 28938
Query: 2816 SAVHVPAPGGAPPIRIEPS------SSRVAEGQTLDLKCVVPGQAHAQV---TWHKRGGN 2866
V APG + S S+ +G + + ++ + ++V W K
Sbjct: 28939 ----VDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGRWLKCNYT 28994
Query: 2867 LPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQP 2926
+ V + +S D+ E+ ++G + T + P
Sbjct: 28995 I-----VSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELD 29049
Query: 2927 IYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA------RHQTHGSQLRLHL 2980
+ + G L L+ V G+ ++ W K L ++ + +
Sbjct: 29050 ARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKF 29109
Query: 2981 VSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDAS 3040
+DSG+Y + G + S V V S G +L S Q+ +
Sbjct: 29110 CDRSDSGKYTLTVKNASGTKA-VSVMVKVLDSPGPCGKLTV--------SRVTQEKCTLA 29160
Query: 3041 FKCLIHDGAAPISLEWKTRNQELEDN-VHISPNGSIITIVGTR--PSNHGTYRCVASNAY 3097
+ DG A I+ R + N V + ++ V TR +N +R A N Y
Sbjct: 29161 WSLPQEDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIKNNEYIFRVRAVNKY 29220
Query: 3098 GV-----AQSVVNLSVHGPPTVSVLPEGP---------VWVKV----GKAVTLECVSAGE 3139
G ++ +V + P+ +PE W K G ++ V E
Sbjct: 29221 GPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVDKRE 29280
Query: 3140 PRSSARWTRISSTPAKLEQR--TYGLMDS-------HAVLQISSAKPSDAGTYVCLAQNA 3190
+ S RWTR++ + R LM+ AV +++PS+A ++ + +
Sbjct: 29281 -KKSLRWTRVNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFISCREPS 29339
Query: 3191 LGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRS 3250
+VDT + + T G+ ++ T W ++ +
Sbjct: 29340 YTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQ------EKDTDQWYRVHT 29393
Query: 3251 PLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE---- 3306
+ +P + + A + G +E + + P +P+
Sbjct: 29394 ----NATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELA 29449
Query: 3307 -----HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA----TARNELLHFERAAP 3357
+++AG +++L G PP WS+ G L RA T LL ++
Sbjct: 29450 DDLKKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNR 29509
Query: 3358 EDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASV 3417
D+G+Y N+ G A + V PG P+ + S +V +T ++ T GA V
Sbjct: 29510 YDAGKYTIEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPV 29569
Query: 3418 EFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWG---K 3474
+ + R +R FK + RI L + + +G
Sbjct: 29570 NNY--IVEKREAAMRAFK-----TVTTKCSKTLYRISGLVEGTMYYFRVLPENIYGIGEP 29622
Query: 3475 AQASAQLVIQALPSV-----LINIRTSVQTV------------VVGHAVEFECLALGDPK 3517
+ S +++ +P V ++++ S T+ + G+ +E C A +
Sbjct: 29623 CETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLE-ACKAGTE-- 29679
Query: 3518 PQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLL------ 3571
W KV L+P +++ + + + +R A N G ++ +
Sbjct: 29680 ---RWMKV-VTLKPTVLEH----TVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQD 29731
Query: 3572 VQALPQI---SMPQE-VRVPAGSAAVFPCIASGYPTPDISW----SKLDGS--LPPDSRL 3621
++ LP I +MPQ+ + VPAG +G P P SW SKL S + ++
Sbjct: 29732 LRVLPTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHT 29791
Query: 3622 ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIK- 3680
+ L + +D G Y N G + + ++ P P IK
Sbjct: 29792 KVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGP----------PTGPIKI 29841
Query: 3681 DAYRKFEIKITFRPDSADG 3699
D I I++ P DG
Sbjct: 29842 DEIDATSITISWEPPELDG 29860
Score = 54.7 bits (130), Expect = 2e-06
Identities = 182/870 (20%), Positives = 294/870 (33%), Gaps = 146/870 (16%)
Query: 2026 VATSPAGTAQ-ARIQVVVLSASDASPPPVKIESS---SPSVTEGQTLDLNCVVAGSAHAQ 2081
+A + AG + A + VL PP + ++++ + G TL L+ ++ G +
Sbjct: 17190 LAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPK 17249
Query: 2082 VTWYRRGGSLPPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHG 2137
VTW + P ++ GS+L + + D G Y VEN +G K S+ V VL
Sbjct: 17250 VTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGSKTVSVKVLVL-- 17307
Query: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLD------LNCVVPGQAHAQVTWH----- 2186
GP P I S ++ + LD N VV + A W
Sbjct: 17308 DKPGP-----PRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYVVERRDVASAQWSPLSAT 17362
Query: 2187 KRGGSLPARHQTHGS--LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPI 2244
+ S A+H G+ L R+ G + V T P++A P+
Sbjct: 17363 SKKKSHFAKHLNEGNQYLFRVAAENQYGRGPF----VETPKPIKAL-----------DPL 17407
Query: 2245 PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK--RGGSLP-----ARHQVRGSRLY 2297
P G DL V + + W K R G P +Q G++ +
Sbjct: 17408 HP-----------PGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDW 17456
Query: 2298 IFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPI----RIEPSSSQ-- 2351
I + + V G V G L +T PI ++ P S +
Sbjct: 17457 IKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGL---PDTTIPIECQEKLVPPSVELD 17513
Query: 2352 --------VAEGQTLDLNCVVPGQSHAQVTWHKRGGSL------PVRHQTHGSLLRLYQA 2397
V G T+ ++ G W G + V S+L +
Sbjct: 17514 VKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNC 17573
Query: 2398 SPADSGEYVCRVLGSSVPLEASVLVTI-----EPAGSVPALGVTPTVRIESSSSQVAEGQ 2452
D+GEY V ++ +V +T+ P G + L VTP S +G
Sbjct: 17574 LRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGG 17633
Query: 2453 TLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSG-EYVCRVVGSS-- 2509
+ +N +V Q + TW G + + GS L++ G EYV RV +
Sbjct: 17634 SPVINYIVEKQDTRKDTW----GVVSS-----GSSKTKLKIPHLQKGCEYVFRVRAENKI 17684
Query: 2510 --GTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITW 2567
G S + + S G I ++A+++ L S IT
Sbjct: 17685 GVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVS-------WTLPKSDGGSPITG 17737
Query: 2568 YKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPS 2627
Y R ++ G +R+ + AD V + G + E + S PS
Sbjct: 17738 Y-----YMERREVTGKWVRVNKTPIADLKFRVTGLYEG-NTYEFRVFAENLAGLSKPSPS 17791
Query: 2628 VSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYK---RGGSLPSRHQTHGSHLRLH 2684
P I++ P G ++ + A + W K GGS +
Sbjct: 17792 SDP---IKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTA 17848
Query: 2685 QMSVADSGEYVCRANNNIDAL-----------EASIVISVSPS--AGSPSAPGSSMPIRI 2731
Q + + E + + + L A+IV P A S A P +
Sbjct: 17849 QWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDILHPPEV 17908
Query: 2732 ESSSS-----HVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT------RGSRLRL 2780
E + V G+T+ + V G+ +TW K G L + L++
Sbjct: 17909 ELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQI 17968
Query: 2781 HHVSPADSGEYVCRVMGSSGPLEASVLVTI 2810
AD G+Y+ SSG + S +V +
Sbjct: 17969 KEAVRADHGKYIISAKNSSGHAQGSAIVNV 17998
Score = 54.7 bits (130), Expect = 2e-06
Identities = 106/511 (20%), Positives = 192/511 (37%), Gaps = 62/511 (12%)
Query: 2248 RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQA 2301
R+ T+ G L L V G+ ++ W K L +V + + I
Sbjct: 29051 RLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFC 29110
Query: 2302 SPADAGQY---VCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVA----- 2353
+D+G+Y V AS S+ V V + G P G R+ +A
Sbjct: 29111 DRSDSGKYTLTVKNASGTKAVSVMVKVLDSPG-----PCGKLTVSRVTQEKCTLAWSLPQ 29165
Query: 2354 -EGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRV--- 2409
+G + +V + +++ W G P L++ + EY+ RV
Sbjct: 29166 EDGGAEITHYIVERRETSRLNWVIVEGECPTLSYVVTRLIK--------NNEYIFRVRAV 29217
Query: 2410 --LGSSVPLEASVLV-----TI-EPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVA 2461
G VP+E+ +V TI P G +G I + ++G N LV
Sbjct: 29218 NKYGPGVPVESEPIVARNSFTIPSPPGIPEEVGTGKEHIIIQWTKPESDGGNEISNYLVD 29277
Query: 2462 GQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQ 2521
+ + W + + + V+ +RL++ + ++ V ++G E S
Sbjct: 29278 KREKKSLRWTR----VNKDYVVYDTRLKVTSLMEGCDYQFRVTAVNAAGNSEPSEASNFI 29333
Query: 2522 QRLSGSHSQGVAYPVRIESS---SASLA------NGHTLDLNCLVASQAPHTITWYKRGG 2572
S++ G R+ + S SLA +G T + ++ Q T WY+
Sbjct: 29334 SCREPSYTPGPPSAPRVVDTTKHSISLAWTKPMYDGGTDIVGYVLEMQEKDTDQWYR--- 29390
Query: 2573 SLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETS-LIVTIQGSGSSHVPSVSPP 2631
+ + I + +P + + N G E S I I+ +P +
Sbjct: 29391 -VHTNATIRNTEFTVPDLKMGQKYSFRVAAVNVKGMSEYSESIAEIEPVERIEIPDLELA 29449
Query: 2632 IRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH--QTHGSH--LRLHQMS 2687
++ + T+ G +L L V+ +P +ITW K+G L SR T S+ L + +++
Sbjct: 29450 DDLKKTV-TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVN 29508
Query: 2688 VADSGEYVCRANNNIDALEASIVISVSPSAG 2718
D+G+Y A N A++++ V + G
Sbjct: 29509 RYDAGKYTIEAENQSGKKSATVLVKVYDTPG 29539
Score = 53.5 bits (127), Expect = 4e-06
Identities = 97/412 (23%), Positives = 156/412 (37%), Gaps = 54/412 (13%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLL-IPAITTADAGFYLC 2025
V AG ++R++ G P+ +TW K+ +L +A E T+ TLL IP D G ++
Sbjct: 20788 VRAGLSIRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVM 20847
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTL--DLNCVVAGSAHAQVT 2083
+PAG + V VL +P PV + + TL DL + GS
Sbjct: 20848 TIENPAGKKSGFVNVRVLD----TPGPVLNLRPTDITKDSVTLHWDLPLIDGGSRITNYI 20903
Query: 2084 WYRRGGSLPPH----TQVHGSRLRLPQVSPADSGEYVCRV--ENGSGPKEASITVSVLHG 2137
+R + + T+ H ++ +S + EY RV EN G E + T
Sbjct: 20904 VEKREATRKSYSTATTKCHKCTYKVTGLS--EGCEYFFRVMAENEYGIGEPTETTE---- 20957
Query: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAH---AQVTWH----KRGG 2190
PV S P P S ++ + ++ P H +++T + +R G
Sbjct: 20958 --------PVKASEAP--SPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGYVIEAQRKG 21007
Query: 2191 SLPARHQTHGSLLRLHQVTPADSGEYVCHVV-----GTSGPLEASVLVTIEASVIPGPIP 2245
S H T L + EY V+ G S P E+ ++ E +++P +
Sbjct: 21008 SDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLP-ELD 21066
Query: 2246 PVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR------GSRLYIF 2299
I G + + V G+ VTW K L +V + L I
Sbjct: 21067 LRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNIN 21126
Query: 2300 QASPADAGQYVCRASNGM-EASITVTVTGTQGANLAYPAGSTQPIRIEPSSS 2350
+ +D+G Y A N + E +T+ P T PI+ + SS
Sbjct: 21127 ECVRSDSGPYPLTARNIVGEVGDVITIQVHD-----IPGPPTGPIKFDEVSS 21173
Score = 53.5 bits (127), Expect = 4e-06
Identities = 324/1657 (19%), Positives = 572/1657 (34%), Gaps = 265/1657 (15%)
Query: 2065 GQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV---HGSRLRLPQVSPAD---SGEYVCR 2118
G ++ L ++G + WY+ L + V + + L + AD SG Y +
Sbjct: 26887 GTSVKLRAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELK 26946
Query: 2119 VENGSGPKEASITVSVLH--GTHSGP-SYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVV 2175
+ N G A+I V +L G GP + V + P + +G + +V
Sbjct: 26947 LRNAMGSASATIRVQILDKPGPPGGPIEFKTVTAEKITLLWRPPAD---DGGAKITHYIV 27003
Query: 2176 PGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHV-----VGTSGPLEAS 2230
+ ++V W L T +++ EY+ V G PLE+
Sbjct: 27004 EKRETSRVVWSMVSEHLEECIITTTKIIK--------GNEYIFRVRAVNKYGIGEPLESD 27055
Query: 2231 VLVTIEASVIPGP--IPPV-RIESSSSTV------AEGQTLDLSCVVAGQAHAQVTWYKR 2281
+V A V PGP IP V +I +S TV A+G + + + + W+K
Sbjct: 27056 SVVAKNAFVTPGPPGIPEVTKITKNSMTVVWSRPIADGGSDISGYFLEKRDKKSLGWFK- 27114
Query: 2282 GGSLPARHQVRGSRLYIFQASPADAGQY-VCRASNGMEASITVTVTGTQGANLAYPAGST 2340
+ +R +R + + QY VC + + + + A+ P G
Sbjct: 27115 ----VLKETIRDTRQKVTGLTENSDYQYRVCAVNAAGQGPFSEPSEFYKAADPIDPPGPP 27170
Query: 2341 QPIRIEPS---------SSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSL 2391
IRI S S V +G + VV + + W VR
Sbjct: 27171 AKIRIADSTKSSITLGWSKPVYDGGSAVTGYVVEIRQGEEEEWTTVSTKGEVRTTE---- 27226
Query: 2392 LRLYQASPADSG-EYVCRV-----LGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSS 2445
Y S G Y RV G P+E + V + P + + +R +
Sbjct: 27227 ---YVVSNLKPGVNYYFRVSAVNCAGQGEPIEMNEPVQAKDILEAPEIDLDVALR----T 27279
Query: 2446 SQVAE-GQTLDLNCLVAGQAHAQVTWHKRGGSL--PARHQVHG----SRLRLLQVTPADS 2498
S +A+ G+ + + G+ VTW K +L AR+ + S L + QVT D+
Sbjct: 27280 SVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDT 27339
Query: 2499 GEYVCRVVGSSGTQEAS-VLVTIQQRLSGSHSQGVAYPVRIESS---SASLANGHTLDLN 2554
G+Y+ + G ++S V V + + V + R + L +G + +N
Sbjct: 27340 GKYILTIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIIN 27399
Query: 2555 CLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLI 2614
++ + TW S+ S H+ + ++ ++ + N G E
Sbjct: 27400 YVIEKRDATKRTW-----SVVS-HKCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEP--C 27451
Query: 2615 VTIQGSGSSHVPSVSPPIRIESSSPTVV---------EGQTLDLNCVVARQPQAIITWYK 2665
T + ++ VP+ + ++ S+ T V +G ++ VV R+ + TW
Sbjct: 27452 ETTEPVKAAEVPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSH 27511
Query: 2666 RGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIV----ISVSPSAGSPS 2721
G S + +L + SV + + D + + + ++P
Sbjct: 27512 AGISKTCEIEVS----QLKEQSVLEFRVFAKNEKGLSDPVTIGPITVKELIITPEVDLSD 27567
Query: 2722 APGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSR---- 2777
PG+ + +RI G + L G+ ++W K G L R S+
Sbjct: 27568 IPGAQVTVRI---------GHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENK 27618
Query: 2778 --LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSS 2835
L + + G+Y V+ + +V +T+ G P PIR +
Sbjct: 27619 ITLSIKNAKKEHGGKYT--VILDNAVCRIAVPITVITLG------PPSKPKGPIRFDE-- 27668
Query: 2836 SRVAEGQTLDLKCVVP-GQAHAQVTWH---KRGGNLPARHQVHGPLLRLNQVSP--ADSG 2889
+ ++ L VP ++T + KR + V + R P
Sbjct: 27669 ---IKADSVILSWDVPEDNGGGEITCYSIEKRETSQTNWKMVCSSVARTTFKVPNLVKDA 27725
Query: 2890 EYSCQVT-----GSSGTLEASVLVTIEP-SSPGPIPAPGLAQPIYIEASS--------SH 2935
EY +V G S L +S++V PGP PG +P+ +S +
Sbjct: 27726 EYQFRVRAENRYGVSQPLVSSIIVAKHQFRIPGP---PG--KPVIYNVTSDGMSLTWDAP 27780
Query: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAAS 2995
V +G + V + + W K S + + + L L Y +A
Sbjct: 27781 VYDGGSEVTGFHVEKKERNSILWQKVNTSPISGREYRATGLVEGL--DYQFRVYAENSAG 27838
Query: 2996 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSS-----TVQQGQDASFKCLIHDGAA 3050
P + FT+ V P +DPP + ++ + + DG +
Sbjct: 27839 LSSPSDPSKFTLAVSP--------------VDPPGTPDYIDVTRETITLKWNPPLRDGGS 27884
Query: 3051 PI---SLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGV----AQS- 3102
I S+E + N+ + T+ G P + +R +A NA G +QS
Sbjct: 27885 KIVGYSIEKRQGNERWVRCNFTDVSECQYTVTGLSPGDRYEFRIIARNAVGTISPPSQSS 27944
Query: 3103 --VVNLSVHGPPTVSVLPE--GPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ 3158
++ + PP V PE + +K G+++ ++ + G P W + K
Sbjct: 27945 GIIMTRDENVPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMN 28004
Query: 3159 RTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV-IVDTGAMAPGAPQVQAE 3217
+ L + A G Y A+NA G+A+ +++V + DT G
Sbjct: 28005 MEITDVLGSTSLFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVG------- 28057
Query: 3218 EAELTVEAGHTATLRCSA--TGSPAPTIHW---SKLRSPLPW---QHRLEGDTLIIPRVA 3269
T G TL A AP H+ + S L W + + E + ++
Sbjct: 28058 PIRFTNITGEKMTLWWDAPLNDGCAPITHYIIEKRETSRLAWALIEDKCEAQSYTAIKLI 28117
Query: 3270 QQDSGQYICNATSPAG-----HAEATIILHVESPPYATTVPEHASV-------------- 3310
+ Q+ +A + G ++ + + P A +PE +++
Sbjct: 28118 NGNEYQFRVSAVNKFGVGRPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPES 28177
Query: 3311 QAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNK 3370
G +Q L T +W +V S P T F+ + Y V +
Sbjct: 28178 DGGSEIQQYILERREKKST-RWVKVISKRPISET------RFKVTGLTEGNEYEFHVMAE 28230
Query: 3371 ----VGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE---------TKSIGASV 3417
VG A ++L+ P + P T T + T LE + IG +
Sbjct: 28231 NAAGVGPASGISRLIKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYII 28290
Query: 3418 EFHCA-------VPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHG 3470
E A V ++ + R+ Q + + + SC+ T
Sbjct: 28291 EMCKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVT------- 28343
Query: 3471 PWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGH-- 3528
G +A +L L + N + V G ++ G P P WSK +
Sbjct: 28344 --GTIKAVDRLTAPEL-DIDANFK-QTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLS 28399
Query: 3529 LRPGI--VQSGGVVRIAHVELADAGQYRCTATNAAGT 3563
LR I S + + + DAG+Y T N +G+
Sbjct: 28400 LRADIHTTDSFSTLTVENCNRNDAGKYTLTVENNSGS 28436
Score = 53.1 bits (126), Expect = 6e-06
Identities = 94/444 (21%), Positives = 153/444 (34%), Gaps = 69/444 (15%)
Query: 3184 VCLAQNALGTAQ--KQVEVIVDTGAMAPGAPQVQAEEAELT-VEAGHTATLRCSATGSPA 3240
VC AQN +G + + E I + P + A +L V AG L G PA
Sbjct: 18577 VC-AQNQVGIGRPAELKEAIKPKEILEPPEIDLDASMRKLVIVRAGCPIRLFAIVRGRPA 18635
Query: 3241 PTIHWSKLR-SPLPWQHRLE-GDT---LIIPRVAQQDSGQYICNATSPAGHAEATIILHV 3295
P + W K+ + + +++ DT L+IP + DSG+Y +PAG + + V
Sbjct: 18636 PKVTWRKVGIDNVVRKGQVDLVDTMAFLVIPNSTRDDSGKYSLTLVNPAGEKAVFVNVRV 18695
Query: 3296 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATA---------- 3345
P + ++ + + C PP S+V + + A
Sbjct: 18696 LDTPGPV-----SDLKVSDVTKTSCHVSWAPPENDGGSQVTHYIVEKREADRKTWSTVTP 18750
Query: 3346 --RNELLHFERAAPEDSGRYRCRVTNKVGSAE---------AFAQLLVQGPPGSLPATSI 3394
+ H P + +R N+ G A L PP L T +
Sbjct: 18751 EVKKTSFHVTNLVPGNEYYFRVTAVNEYGPGVPTDVPKPVLASDPLSEPDPPRKLEVTEM 18810
Query: 3395 PAGSTPTVQVTPQLETKSIGASVEFHCA------VPSDRGTQLRWFKEGGQLPPGHSVQD 3448
S + P + GA ++ + P+DR T+ V+D
Sbjct: 18811 TKNSATLAWLPP---LRDGGAKIDGYITSYREEEQPADRWTEY------------SVVKD 18855
Query: 3449 GVLRIQNLDQSCQGTYICQAHGPWG-----KAQASAQLVIQALPSVLINIRTSVQTVVVG 3503
L + L + + + A G +A+ + Q LP + + T+ G
Sbjct: 18856 LSLVVTGLKEGKKYKFRVAARNAVGVSLPREAEGVYEAKEQLLPPKI--LMPEQITIKAG 18913
Query: 3504 HAVEFECLALGDPKPQVTWSK------VGGHLRPGIVQSGGVVRIAHVELADAGQYRCTA 3557
+ E G P P W K HL S ++ I V D+G Y TA
Sbjct: 18914 KKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTA 18973
Query: 3558 TNAAGTTQSHVLLLVQALPQISMP 3581
N++GT + ++V P P
Sbjct: 18974 ENSSGTDTQKIKVVVMDAPGPPQP 18997
Score = 53.1 bits (126), Expect = 6e-06
Identities = 168/819 (20%), Positives = 282/819 (34%), Gaps = 109/819 (13%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT-DIATLLIPAITTADAGFYLC 2025
+ AG ++RL+ G P+ + W K G + A + T +L++ + D+G Y
Sbjct: 22954 IRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTL 23013
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPV-----KIESSSPSVT-EGQTLDLNCVVAGSAH 2079
+ +GT A + V VL D PPV +I S S+T E LD GS
Sbjct: 23014 TLENSSGTKSAFVTVRVL---DTPSPPVNLKVTEITKDSVSITWEPPLLD-----GGSKI 23065
Query: 2080 AQVTWYRRGGSLPPH----TQVHGSRLRLPQVSPADSGEYVCRVENGSG---PKEASITV 2132
+R + + T H + ++ Q+ S + EN G P + + +
Sbjct: 23066 KNYIVEKREATRKSYAAVVTNCHKNSWKIDQLQEGCSYYFRVTAENEYGIGLPAQTADPI 23125
Query: 2133 SVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK--RGG 2190
V P V TR + +G + + +V QA W + R
Sbjct: 23126 KVAE-VPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQYIVEMQAKHSEKWSECARVK 23184
Query: 2191 SLPARHQTHGSLLRLHQVTPADSG-EYVCHVV-----GTSGPLEASVLVTIEASVIPGPI 2244
SL A +T G EY+ VV G S P +V + + VI
Sbjct: 23185 SLQA------------VITNLTQGEEYLFRVVAVNEKGRSDPRSLAVPIVAKDLVIE--- 23229
Query: 2245 PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR--------GSRL 2296
P V+ SS +V GQ L + ++G+ +TW K G LP + R + L
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDG--LPLKQTTRINVTDSLDLTTL 23287
Query: 2297 YIFQASPADAGQYVCRASN--GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAE 2354
I + D GQY +N G + + VT L P P++ + S AE
Sbjct: 23288 SIKETHKDDGGQYGITVANVVGQKTASIEIVT------LDKPDPPKGPVKFDDVS---AE 23338
Query: 2355 GQTLDLN--CVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLR--LYQASPADSGEYVCRVL 2410
TL N G KR + V ++ R L EY R+
Sbjct: 23339 SITLSWNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIF 23398
Query: 2411 -----GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAE-------GQTLDLNC 2458
G S LE+ +V P P TP S S V + G + +
Sbjct: 23399 AENRYGQSFALESDPIVAQYPY-KEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGY 23457
Query: 2459 LVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLV 2518
+ + + W K ++ +H ++ + + E+ G +AS
Sbjct: 23458 HLERKERNSILWTKVNKTI-----IHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNS 23512
Query: 2519 TIQQRLSGSHSQGVAYPVRIESSSASLA------NGHTLDLNCLVASQAPHTITWYKRGG 2572
G P+ ++ + +L +G ++ +V + W K
Sbjct: 23513 ECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMK--- 23569
Query: 2573 SLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAG--SRETSLIVTIQGSGSSHVPSVSP 2630
S ++ ++ + +T E+ N AG S+ + I +P +S
Sbjct: 23570 --ASFTNVIETQFTVSGLTEDQRYEFRVIAKNAAGAISKPSDSTGPITAKDEVELPRISM 23627
Query: 2631 PIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVA- 2689
+ + V G+T L V +P I W + + + + + +
Sbjct: 23628 DPKFRDTI-VVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVK 23686
Query: 2690 -----DSGEYVCRANNNIDALEASIVISVSPSAGSPSAP 2723
D G+Y+ RA+N + + + V G P P
Sbjct: 23687 DAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGPPEGP 23725
Score = 53.1 bits (126), Expect = 6e-06
Identities = 189/926 (20%), Positives = 331/926 (35%), Gaps = 114/926 (12%)
Query: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLI 2012
P V+ + V G+ +++ +G P TITW K+G L R ++ D+ TL I
Sbjct: 23230 PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGLPLKQTTRINVTDSLDLTTLSI 23289
Query: 2013 PAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNC 2072
D G Y + G A I++V L D PVK + S E TL N
Sbjct: 23290 KETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKGPVKFDDVS---AESITLSWNP 23346
Query: 2073 VVAGSAHAQVTWY---RRGGSLPPHTQVHGSRLRLP-QVSPADSG-EYVCRV--ENGSGP 2125
+ + Q+T Y +R + V + R +V+ +G EY R+ EN G
Sbjct: 23347 PLY-TGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKVTKLKTGTEYQFRIFAENRYGQ 23405
Query: 2126 K---EASITVSVLHGTHSGPSYTP-VPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHA 2181
E+ V+ GP TP ++ + V G + + + +
Sbjct: 23406 SFALESDPIVAQYPYKEPGPPGTPFATAISKDSMVIQWHEPVNNGGSPVIGYHLERKERN 23465
Query: 2182 QVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGT-SGPLEASVLVTIEASVI 2240
+ W K ++ H T L + + Y ++VG + V +
Sbjct: 23466 SILWTKVNKTI--IHDTQFKAQNLEEGIEYEFRVYAENIVGVGKASKNSECYVARDPCDP 23523
Query: 2241 PGPIPPVRIESSSST------VAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGS 2294
PG P+ ++ + T V +G ++ +V + W K + Q S
Sbjct: 23524 PGTPEPIMVKRNEITLQWTKPVYDGGSMITGYIVEKRDLPDGRWMKASFTNVIETQFTVS 23583
Query: 2295 RL-----YIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSS 2349
L Y F+ +A + + S+ T +T L P S P + +
Sbjct: 23584 GLTEDQRYEFRVIAKNAAGAISKPSDS-----TGPITAKDEVEL--PRISMDPKFRD--T 23634
Query: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHK------RGGSLPVRHQTHGSLLRLYQASPADSG 2403
V G+T L V G+ + W + +++ +LL + A D G
Sbjct: 23635 IVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKALLIVKDAIRIDGG 23694
Query: 2404 EYVCR---VLGS-SVPLEASVLVTI-EPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC 2458
+Y+ R V GS S P+ VL P G V GVT + S + +G + +
Sbjct: 23695 QYILRASNVAGSKSFPVNVKVLDRPGPPEGPVQVTGVTSEKCSLTWSPPLQDGGSDISHY 23754
Query: 2459 LVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTP-ADSGEYVCRVVG------SSGT 2511
+V + +++ W ++ A V S L+VT + EYV R++
Sbjct: 23755 VVEKRETSRLAW-----TVVASEVVTNS----LKVTKLLEGNEYVFRIMAVNKYGVGEPL 23805
Query: 2512 QEASVLVTIQQRLSGSHSQGVAYPVRIESSSASL----ANGHTLDLNCLVASQAPHTITW 2567
+ A VL+ L G + +S + ++G + + +V + I W
Sbjct: 23806 ESAPVLMKNPFVLPGPPKSLEVTNIAKDSMTVCWNRPDSDGGSEIIGYIVEKRDRSGIRW 23865
Query: 2568 YKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPS 2627
K ++ +I RLR+ +T E+ N AG E S T+ V
Sbjct: 23866 IK-----CNKRRITDLRLRVTGLTEDHEYEFRVSAENAAGVGEPS-PATVYYKACDPVFK 23919
Query: 2628 VSPPIR---IESSSPTV--------------VEGQTLDLNCVVARQPQAIITWYKRGGSL 2670
PP ++++ ++ + G +++ C + I+T
Sbjct: 23920 PGPPTNAHIVDTTKNSITLAWGKPIYDGGSEILGYVVEI-CKADEEEWQIVT-------- 23970
Query: 2671 PSRHQTHGSHLRLHQMSVADSGEYVCR--ANNNIDALEASIVISVSPSAGSPSAPGSSMP 2728
QT R + + EY R A N + EA+ V AP +
Sbjct: 23971 ---PQTGLRVTRFEISKLTEHQEYKIRVCALNKVGLGEATSVPGTVKPEDKLEAPELDLD 24027
Query: 2729 IRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ----TRGSRLRLHHVS 2784
+ V G + ++ G+ ++TW + G Q ++L + +
Sbjct: 24028 SELRKGIV-VRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCD 24086
Query: 2785 PADSGEYVCRVMGSSGPLEASVLVTI 2810
D+G+Y+ ++ SSG A V V +
Sbjct: 24087 RNDAGKYILKLENSSGSKSAFVTVKV 24112
Score = 52.8 bits (125), Expect = 8e-06
Identities = 95/403 (23%), Positives = 156/403 (38%), Gaps = 46/403 (11%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPA-ITTADAGFYLC 2025
+ A T+RL+ G P+ + W ++ G +A E T TLLI + D+G Y+
Sbjct: 21872 IRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLLIVGNVNRFDSGKYIL 21931
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKI-ESSSPSVTEGQTLDLNCVVAGSAHAQVTW 2084
+ +G+ A + V VL + P +K+ E + SVT T D + GS
Sbjct: 21932 TVENSSGSKSAFVNVRVLD-TPGPPQDLKVKEVTKTSVT--LTWDPPLLDGGSKIKNYIV 21988
Query: 2085 YRRGGSLPPH----TQVHGSRLRLPQVSPADSGEYVCRVENGSG---PKEASITVSVLHG 2137
+R + + T H + ++ Q+ S + EN G P E + +V
Sbjct: 21989 EKRESTRKAYSTVATNCHKTSWKVDQLQEGCSYYFRVLAENEYGIGLPAETAESVKA--- 22045
Query: 2138 THSGPSYTPV-PGSTRPIRIEPSSSHVA------EGQTLDLNCVVPGQAHAQVTWHKRGG 2190
S P+ PG + + +S ++ +G + L +V Q W
Sbjct: 22046 -----SERPLPPGKITLMDVTRNSVSLSWEKPEHDGGSRILGYIVEMQTKGSDKW----A 22096
Query: 2191 SLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIE 2250
+ T ++ L Q + G S P + SV V + VIP P ++
Sbjct: 22097 TCATVKVTEATITGLIQGEEYSFRVSAQNEKGISDPRQLSVPVIAKDLVIP---PAFKLL 22153
Query: 2251 SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV------RGSRLYIFQASPA 2304
++ TV G+ L + G+ VTW+K L +V S L I A
Sbjct: 22154 FNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACRE 22213
Query: 2305 DAGQYVCRASNGM-EASITVTVTGTQGANLAYPAGSTQPIRIE 2346
D G YV + +N EA T+ V L P T P++++
Sbjct: 22214 DVGHYVVKLTNSAGEAIETLNV-----IVLDKPGPPTGPVKMD 22251
Score = 52.4 bits (124), Expect = 1e-05
Identities = 54/258 (20%), Positives = 88/258 (34%), Gaps = 58/258 (22%)
Query: 2609 RETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGG 2668
RE + T + +P P + + TV+EG+++ L C ++ P +TWY+
Sbjct: 922 REAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDY 981
Query: 2669 SLPS------RHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPS------ 2716
+ S Q+ + L + + DSG + C A N + S ++V S
Sbjct: 982 QIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKE 1041
Query: 2717 ----------------------------------AGSPSAPGSSMPIRIESSSSHVAEGE 2742
G P+AP ++ + EG
Sbjct: 1042 TTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQK----LVEGG 1097
Query: 2743 TLDLNCVVPGQAHAQVTWHKRGGSLPS--------HHQTRGSRLRLHHVSPADSGEYVCR 2794
++ C V G V W K G L + + QT +L + D+GEY
Sbjct: 1098 SVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIV 1157
Query: 2795 VMGSSGPLEASVLVTIEA 2812
V G AS + EA
Sbjct: 1158 VRNKHGETSASASLLEEA 1175
Score = 52.4 bits (124), Expect = 1e-05
Identities = 112/523 (21%), Positives = 178/523 (34%), Gaps = 91/523 (17%)
Query: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW----SKLRSPLPWQHRLEG-DTLIIP 3266
P + + V G TA RC TG P P ++W +R ++ R +G L I
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIHYLDIV 1900
Query: 3267 RVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTP 3326
D+G+ A +P G E + L ++ +V A E H
Sbjct: 1901 DCKSYDTGEVKVTAENPEGVIEHKVKLEIQQREDFRSVLRRAPEPRPEFH-----VHEPG 1955
Query: 3327 PLTFQWSRVGSSLPGRATARNELLHFERA-------APEDSGRYRCRVTNKVGSAEAFAQ 3379
L F+ +V P T E++ +RA PE+S R + + + E + +
Sbjct: 1956 KLQFEVQKVDR--PVDTTETKEVVKLKRAERITHEKVPEESEELRSKFKRR--TEEGYYE 2011
Query: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
+ +E KS + + + L W KE +
Sbjct: 2012 AITA------------------------VELKSRKKDESYEELLRKTKDELLHWTKELTE 2047
Query: 3440 LPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQT 3499
++G + I K + S + P + I++ QT
Sbjct: 2048 EEKKALAEEGKITIPTFKPD--------------KIELSPSM---EAPKIFERIQS--QT 2088
Query: 3500 VVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI-------VQSGGVVRIAHVELADAGQ 3552
V G F +G P P+ W K G + + + I V D+
Sbjct: 2089 VGQGSDAHFRVRVVGKPDPECEWYKNGVKIERSDRIYWYWPEDNVCELVIRDVTAEDSAS 2148
Query: 3553 YRCTATNAAGTTQSHVLLLVQALPQISMPQE----VRVPAGSAAVFPCIASGYPTPDISW 3608
A N AG T SH LLVQA I+ QE V + A F C S P + W
Sbjct: 2149 IMVKAINIAGETSSHAFLLVQAKQLITFTQELQDVVAKEKDTMATFECETS-EPFVKVKW 2207
Query: 3609 SKLDG-------SLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPER 3661
K DG S + + L + ++ DA Y C + VK A L V
Sbjct: 2208 YK-DGMEVHEGDKYRMHSDRKVHFLSILTIDTSDAEDYSCVLVEDE-NVKTTAKLIVEGA 2265
Query: 3662 VVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYN 3704
VV + + +P ++Y E++ P++ +G +N
Sbjct: 2266 VVEFVKELQDIEVP-----ESY-SGELECIVSPENIEGKWYHN 2302
Score = 52.4 bits (124), Expect = 1e-05
Identities = 249/1228 (20%), Positives = 407/1228 (33%), Gaps = 207/1228 (16%)
Query: 2564 TITWYKRGGSLP--SRHQIVGSR----LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTI 2617
T+ W K G +L +R + S+ L I + + D G Y VSN AGS + + +
Sbjct: 25425 TVNWRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIV 25484
Query: 2618 QGSGSSHVPSVSPPIRIESSS---------PTVVEGQTLDLNCVVARQPQAIITWY---- 2664
P PIRI+ S P +G N +V ++ TW+
Sbjct: 25485 LDR-----PGPPGPIRIDEVSCDSITISWNPPEYDGGCQISNYIVEKKETTSTTWHIVSQ 25539
Query: 2665 -KRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAP 2723
S+ T GS +Q V Y + + A+ A S G+P
Sbjct: 25540 AVARTSIKIVRLTTGSE---YQFRVCAENRYGKSSYSESSAVVAEYPFSPPGPPGTPKVV 25596
Query: 2724 GSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHV 2783
++ + + V +G + + + + + + W K L + Q + V
Sbjct: 25597 HATKSTMLVTWQVPVNDGGSRVIGYHLEYKERSSILWSKANKILIADTQMK--------V 25648
Query: 2784 SPADSG-EYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQ 2842
S D G Y RV + + I S VPA P +P + + +
Sbjct: 25649 SGLDEGLMYEYRVYAEN-------IAGIGKCSKSCEPVPARDPCDPPG-QPEVTNITR-K 25699
Query: 2843 TLDLKCVVPG-QAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSG- 2900
++ LK P A++T G + R G L+ N + ++ ++T
Sbjct: 25700 SVSLKWSKPHYDGGAKIT----GYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRY 25755
Query: 2901 -----TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSH-----VTEGQTLDLNCVVPG 2950
A+ V+ S GPI +P + V G+ L +N + G
Sbjct: 25756 EFRVFARNAADSVSEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAG 25815
Query: 2951 QAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPA------DSGEYV-------------- 2990
+ ++W K G + R +T H + D+G+YV
Sbjct: 25816 RPLPVISWAKDGIEIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAV 25875
Query: 2991 -CRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGA 3049
C+ PGP P E + +S P Q+ A I +
Sbjct: 25876 NCKVLDKPGPP--------AGPLEINGLTAEKCSLSWGRP----QEDGGADIDYYIVEKR 25923
Query: 3050 APISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVH 3109
L W EL+ + + N +R N YGV + + ++++
Sbjct: 25924 ETSHLAWTICEGELQM--------TSCKVTKLLKGNEYIFRVTGVNKYGVGEPLESVAIK 25975
Query: 3110 G--PPTVSVLPEGPVWVKVGKAVTLECVSAGEP---------------RSSARWTRISST 3152
P TV P V K C S E ++S RW R++
Sbjct: 25976 ALDPFTVPSPPTSLEITSVTKESMTLCWSRPESDGGSEISGYIIERREKNSLRWVRVNKK 26035
Query: 3153 PA-KLEQRTYGLMDS-------HAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDT 3204
P L ++ GL + +A + PS+ + + IVD+
Sbjct: 26036 PVYDLRVKSTGLREGCEYEYRVYAENAAGLSLPSETSPLIRAEDPVFLPSPPSKPKIVDS 26095
Query: 3205 GAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLI 3264
G V+ G+T + S T + ++S ++ + G T
Sbjct: 26096 GKTTITIAWVKPLFDGGAPITGYTVEYKKSDD-----TDWKTSIQSLRGTEYTISGLTTG 26150
Query: 3265 IPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHAS---VQAGETVQLQCL 3321
V + S + A+ P+ ++ I E P E V+AG + +
Sbjct: 26151 AEYVFRVKSVNKV-GASDPSDSSDPQIAKEREEEPLFDIDSEMRKTLIVKAGASFTMTVP 26209
Query: 3322 AHGTPPLTFQWSRVGSSLPGRA----TARNELLHFERAAPEDSGRYRCRVTNKVGSAEAF 3377
G P WS+ + L RA T L E A DSG+Y + N + +A
Sbjct: 26210 FRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTLTIQNVLSAASLT 26269
Query: 3378 AQLLV---QGPPGSLPATSIPAGSTPTVQVTPQLE---------------TKSIGASVEF 3419
+ V GPP ++ + S P+ + +K SV
Sbjct: 26270 LVVKVLDTPGPPTNITVQDVTKESAVLSWDVPENDGGAPVKNYHIEKREASKKAWVSVTN 26329
Query: 3420 HCAVPSDRGTQLR-----WFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGK 3474
+C S + T L+ +F+ G+ G + ++ +G I + P K
Sbjct: 26330 NCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPA---------ETKEGVKITEKPSPPEK 26380
Query: 3475 AQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIV 3534
++ + ++ + + +V + VE AL K Q W K V
Sbjct: 26381 LGVTS-ISKDSVSLTWLKPEHDGGSRIVHYVVE----AL--EKGQKNWVKCAVAKSTHHV 26433
Query: 3535 QSGGVVRIAHVELADAGQY--RCTATNAAGTTQSHVLLLVQALPQISMPQE--------- 3583
SG L + +Y R A N AG + LLL + + P E
Sbjct: 26434 VSG---------LRENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMKNFPSH 26484
Query: 3584 -VRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL------ENNMLMLPSVRPQDA 3636
V V AGS SG P P ++ S+ L R EN + L DA
Sbjct: 26485 TVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADA 26544
Query: 3637 GTYVCTATNRQGKVKAFAHLQVPERVVP 3664
G Y TA N G KAF ++ V +R P
Sbjct: 26545 GRYEITAANSSGTTKAFINIVVLDRPGP 26572
Score = 52.0 bits (123), Expect = 1e-05
Identities = 105/512 (20%), Positives = 183/512 (35%), Gaps = 64/512 (12%)
Query: 1962 PERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITTA 2018
PE+ + AG+ +R+ G P T W+K + + + + L+I +T
Sbjct: 18905 PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRK 18964
Query: 2019 DAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNC-VVAGS 2077
D+G+Y A + +GT +I+VVV+ A PP I S + L+ +
Sbjct: 18965 DSGYYSLTAENSSGTDTQKIKVVVMDAPGPPQPPFDI-----SDIDADACSLSWHIPLED 19019
Query: 2078 AHAQVTWY-------RRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASI 2130
+ +T Y RG + V + R+ ++ P + R EN G E
Sbjct: 19020 GGSNITNYIVEKCDVSRGDWVTALASVTKTSCRVGKLIPGQEYIFRVRAENRFGISEPLT 19079
Query: 2131 TVSVL----HGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWH 2186
+ ++ G S P V + ++G + + ++ + + W
Sbjct: 19080 SPKMVAQFPFGVPSEPKNARVTKVNKDCIFVAWDRPDSDGGSPIIGYLIERKERNSLLWV 19139
Query: 2187 KRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPP 2246
K +L T L + Y + G+S P + + VT V P P P
Sbjct: 19140 KANDTLV--RSTEYPCAGLVEGLEYSFRIYALNKAGSSPPSKPTEYVTARMPVDP-PGKP 19196
Query: 2247 VRIESSSSTVAEGQTLDLSCVVAGQAH----AQVTWYKRGGSLPARHQVRGSRLYIFQAS 2302
I+ + STV S + A H + ++ LP VR +
Sbjct: 19197 EVIDVTKSTV--------SLIWARPKHDGGSKIIGYFVEACKLPGDKWVR------CNTA 19242
Query: 2303 PADAGQYVCRASNGME--ASITVTVTGTQGANLAYPAGSTQPI---------RIEPSSSQ 2351
P Q A+ G+E A N++ P+ + P+ RI+ S +
Sbjct: 19243 PHQIPQEEYTAT-GLEEKAQYQFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAM 19301
Query: 2352 -----VAEGQTLDLNCVVPGQSHAQVTWHKRG------GSLPVRHQTHGSLLRLYQASPA 2400
V G + L+ V G+ V+W K G + + Q + L L+ +
Sbjct: 19302 KSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRK 19361
Query: 2401 DSGEYVCRVLGSSVPLEASVLVTIEPAGSVPA 2432
DSG+Y SS A++ + + PA
Sbjct: 19362 DSGDYTITAENSSGSKSATIKLKVLDKPGPPA 19393
Score = 52.0 bits (123), Expect = 1e-05
Identities = 86/406 (21%), Positives = 154/406 (37%), Gaps = 51/406 (12%)
Query: 1969 AGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR--SERTDIATLL-IPAITTADAGFYLC 2025
AG V++ G P T+TWRK+ +L AR E TD ++LL IP +T D G Y+
Sbjct: 27285 AGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRNDTGKYIL 27344
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKIESSS---------PSVTEGQTLDLNCVVAG 2076
+ G ++ V + + A+ ++++ S P + +G + +N V+
Sbjct: 27345 TIENGVGEPKSSTVSVKVLDTPAACQKLQVKHVSRGTVTLLWDPPLIDGGSPIINYVIEK 27404
Query: 2077 SAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLH 2136
+ TW S+ H + + +L +S + EN G E T +
Sbjct: 27405 RDATKRTW-----SVVSH-KCSSTSFKLIDLSEKTPFFFRVLAENEIGIGEPCETTEPVK 27458
Query: 2137 GTHSGPSYTPVPGSTRPIRIEPSSSHVA---------EGQTLDLNCVVPGQAHAQVTWHK 2187
VP R + ++ S+ +G ++ VV + + TW
Sbjct: 27459 AAE-------VPAPIRDLSMKDSTKTSVILSWTKPDFDGGSVITEYVVERKGKGEQTWSH 27511
Query: 2188 RGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
G S + + +L + + + + + G S P+ +T++ +I +
Sbjct: 27512 AGISKTCEIE----VSQLKEQSVLEFRVFAKNEKGLSDPVTIGP-ITVKELIITPEVDLS 27566
Query: 2248 RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSR------LYIFQA 2301
I + TV G + L G+ ++W K G L VR S+ L I A
Sbjct: 27567 DIPGAQVTVRIGHNVHLELPYKGKPKPSISWLKDGLPLKESEFVRFSKTENKITLSIKNA 27626
Query: 2302 SPADAGQYVCRASNGM-EASITVTVTGTQGANLAYPAGSTQPIRIE 2346
G+Y N + ++ +TV L P+ PIR +
Sbjct: 27627 KKEHGGKYTVILDNAVCRIAVPITV-----ITLGPPSKPKGPIRFD 27667
Score = 51.6 bits (122), Expect = 2e-05
Identities = 87/365 (23%), Positives = 145/365 (39%), Gaps = 60/365 (16%)
Query: 2009 TLLIPAITTADAG---FYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT-- 2063
T+L +T+ + G + A + G ++ R V ++ D P S+ P T
Sbjct: 29690 TVLEHTVTSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLRVLPTIDLSTMPQKTIH 29749
Query: 2064 --EGQTLDLNCVVAGSAHAQVTWYRRGGSL--------PPHTQVHGSRLRLPQVSPADSG 2113
G+ ++L +AG +W+ G L HT+V ++L + + + D+G
Sbjct: 29750 VPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKV--AKLTIRETTIRDTG 29807
Query: 2114 EYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA-EGQTLDLN 2172
EY ++N +G +I V +L GP P+ + I+ +S ++ E LD
Sbjct: 29808 EYTLELKNVTGTTSETIKVIIL--DKPGPPTGPI----KIDEIDATSITISWEPPELDGG 29861
Query: 2173 CVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTS----GPLE 2228
+ G Q H R G LP S + ++T + EYV V T+ G
Sbjct: 29862 APLSGYVVEQRDAH-RPGWLPVSESVTRSTFKFTRLT--EGNEYVFRVAATNRFGIGSYL 29918
Query: 2229 ASVLVTIEASV-IPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY---KRGGS 2284
S ++ +S+ IPGP ++I S +G TL TWY GGS
Sbjct: 29919 QSEVIECRSSIRIPGPPETLQIFDVS---RDGMTL--------------TWYPPEDDGGS 29961
Query: 2285 -----LPARHQVRGSRLYIFQASPADAGQYVCRA-SNGMEASITVTVTGTQGANLAYPAG 2338
+ R +VR R P +Y + G+E VT +G+ P+
Sbjct: 29962 QVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTAINARGS--GKPSR 30019
Query: 2339 STQPI 2343
++PI
Sbjct: 30020 PSKPI 30024
Score = 51.2 bits (121), Expect = 2e-05
Identities = 80/328 (24%), Positives = 124/328 (37%), Gaps = 45/328 (13%)
Query: 1740 DAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKS 1799
D G YI T + S AELL+ EAP T VE Q+V D F C +
Sbjct: 12799 DEGEYIVTAGQ----DKSVAELLIIEAP----TEFVEHLEDQTVTEFDDAVFSCQLSREK 12850
Query: 1800 PAYTLVWTR----LHNGKLPTRAMDFN-GILTIRNVQLSDAGTYVCTGSNMFAMDQGTAT 1854
+ W R + GK D + L I++ +L D Y C + + A
Sbjct: 12851 A--NVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGVEDR----KSRAR 12904
Query: 1855 LHVQASGTLSAPVVSIHPPQLTVQ-PGQLAEFRCSATGSPTPTLEW-------TGGPGGQ 1906
L V+ PV I PPQ ++ PG F ++W G Q
Sbjct: 12905 LFVE-----EIPVEIIRPPQDILEAPGADVVFLAELNKDKVE-VQWLRNNMVVVQGDKHQ 12958
Query: 1907 LPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQ 1966
+ ++ +IH L++ ++P DQ +Y A + ARA L + P+++ + +
Sbjct: 12959 MMSEGKIHR--LQICDIKPRDQGEY----RFIAKDKEARAKLEL--AAAPKIKTADQDLV 13010
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCV 2026
V G+ + + P A W KE L + + + I D G Y V
Sbjct: 13011 VDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAEQTSFRILEAKKGDKGRYKIV 13070
Query: 2027 ATSPAGTAQARIQVVVLSASDASPPPVK 2054
+ G A+ I + V+ P PV+
Sbjct: 13071 LQNKHGKAEGFINLKVIDV----PGPVR 13094
Score = 50.8 bits (120), Expect = 3e-05
Identities = 152/833 (18%), Positives = 286/833 (34%), Gaps = 163/833 (19%)
Query: 2092 PPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVS----------VLHGTHSG 2141
P T+V LPQ AD+ + KE ++++ VLHG +
Sbjct: 866 PSETRVRAEPTPLPQFPFADTPDTYKSEAGVEVKKEVGVSITGTTVREERFEVLHGREAK 925
Query: 2142 PSYTPVPGSTRPIRIEP-------SSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194
+ T + I + P + V EG+++ L C + G VTW++ + +
Sbjct: 926 VTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIES 985
Query: 2195 ------RHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEAS---------- 2238
Q+ + L + + DSG + C V +G + S + ++ S
Sbjct: 986 SIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKETTAV 1045
Query: 2239 ----------------------------VIPG-PIPPVRI-ESSSSTVAEGQTLDLSCVV 2268
PG P P I + + EG ++ C V
Sbjct: 1046 TEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVVQKLVEGGSVVFGCQV 1105
Query: 2269 AGQAHAQVTWYKRGGSLPARHQVRGS--------RLYIFQASPADAGQY--VCRASNG-- 2316
G V W K G L ++ + S +L I DAG+Y V R +G
Sbjct: 1106 GGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEYTIVVRNKHGET 1165
Query: 2317 -------MEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSH 2369
EA + + Q + Y T ++ EP + A G +
Sbjct: 1166 SASASLLEEADYELLMKSQQ--EMLYQTQVTAFVQ-EPKVGETAPGFVYSEYEKEYEKEQ 1222
Query: 2370 AQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGS 2429
A + ++ VR + E R++ +++ + E
Sbjct: 1223 ALIRKKMAKDTVVVRTYVEDQEFHISSFEERLIKEIEYRIIKTTLE-----ELLEEDGEE 1277
Query: 2430 VPALGVTPTVRIES------SSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLP--ARH 2481
A+ ++ + +ES + ++ EG + +C ++G ++ W+K G + R+
Sbjct: 1278 KMAVDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERY 1337
Query: 2482 QVH-----GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPV 2536
Q+ + LR+ V P D G Y G S + ++ + + P
Sbjct: 1338 QMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEP------AAPLGAPT 1391
Query: 2537 RIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSG 2596
I TL+ + S +P +++ R S ++ +R+ +++PA
Sbjct: 1392 YIP----------TLEPVSRIRSLSPRSVS---RSPIRMSPARMSPARMSPARMSPA--- 1435
Query: 2597 EYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRI-ESSSPTVVEGQTLDLNCVVAR 2655
+S G ET S + + P+ + + S +EGQT + V
Sbjct: 1436 ----RMSPGRRLEETD---------ESQLERLYKPVFVLKPVSFKCLEGQTARFDLKVVG 1482
Query: 2656 QPQAIITWYKRGGSLPSRHQTH--------GSHLRLHQMSVADSGEYVCRANNNIDALEA 2707
+P W+ G + + + TH L + + +DSGE+ A N
Sbjct: 1483 RPMPETFWFHDGQQIVNDY-THKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSI 1541
Query: 2708 SIVISVSPSAGSPSAPGSSMPIRIES-SSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGS 2766
S++++V + P+ +E + ++ EG L++ G + + W K
Sbjct: 1542 SVILTVE------AVEHQVKPMFVEKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDI 1595
Query: 2767 LPSH-------HQTRG-SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
+ H T+G + L++ DS Y + +G V +E
Sbjct: 1596 IVPHKYPKIRIEGTKGEAALKIDSTVSQDSAWYTATAINKAGRDTTRCKVNVE 1648
Score = 50.8 bits (120), Expect = 3e-05
Identities = 65/319 (20%), Positives = 106/319 (33%), Gaps = 87/319 (27%)
Query: 2041 VVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS 2100
V +S S+A + + EG + +C ++G ++ WY+ G + HG
Sbjct: 1281 VDISESEAVESGFDSRIKNYRILEGMGVTFHCKMSGYPLPKIAWYKDGKRIK-----HGE 1335
Query: 2101 R------------LRLPQVSPADSGEYVCRVENGSG--------------PKEASITVSV 2134
R LR+P V P D G Y N G P A +
Sbjct: 1336 RYQMDFLQDGRASLRIPVVLPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPT 1395
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVA------------------------------ 2164
L S +P S PIR+ P+ A
Sbjct: 1396 LEPVSRIRSLSPRSVSRSPIRMSPARMSPARMSPARMSPARMSPGRRLEETDESQLERLY 1455
Query: 2165 --------------EGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLR------ 2204
EGQT + V G+ + W G + TH +++
Sbjct: 1456 KPVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQI-VNDYTHKVVIKEDGTQS 1514
Query: 2205 --LHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIES-SSSTVAEGQT 2261
+ TP+DSGE+ +G SV++T+EA + + P+ +E + + EG
Sbjct: 1515 LIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEA--VEHQVKPMFVEKLKNVNIKEGSR 1572
Query: 2262 LDLSCVVAGQAHAQVTWYK 2280
L++ G + + W K
Sbjct: 1573 LEMKVRATGNPNPDIVWLK 1591
Score = 50.1 bits (118), Expect = 5e-05
Identities = 190/900 (21%), Positives = 307/900 (34%), Gaps = 166/900 (18%)
Query: 1857 VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH-- 1914
++ S ++ AP + TV G A FR G P P EW G ++ +I+
Sbjct: 2069 IELSPSMEAPKIFERIQSQTVGQGSDAHFRVRVVGKPDPECEWYKN-GVKIERSDRIYWY 2127
Query: 1915 ---GGILRLPAVEPT--DQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHA 1969
+ L + T D A + +A + AG+ + A L V + + E V A
Sbjct: 2128 WPEDNVCELVIRDVTAEDSASIMVKAINIAGETSSHAFLLVQ--AKQLITFTQELQDVVA 2185
Query: 1970 GR--TVRLYCRAAGVPSATITWRKEGGSLPP----QARSERTDIATLLIPAITTADAGFY 2023
T+ + P + W K+G + + S+R + L I I T+DA Y
Sbjct: 2186 KEKDTMATFECETSEPFVKVKWYKDGMEVHEGDKYRMHSDR-KVHFLSILTIDTSDAEDY 2244
Query: 2024 LCVATSPAG---TAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080
CV TA+ ++ V+ VK E V E + +L C+V+ +
Sbjct: 2245 SCVLVEDENVKTTAKLIVEGAVVEF-------VK-ELQDIEVPESYSGELECIVS-PENI 2295
Query: 2081 QVTWYRRGGSLPPH-----TQVHG-SRLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
+ WY L + T G L + V+ D GEY ++ K+ + + +
Sbjct: 2296 EGKWYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYSFVIDG----KKTTCKLKM 2351
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEP--SSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL 2192
RPI I S V EG + L V ++ + W K G +
Sbjct: 2352 ---------------KPRPIAILQGLSDQKVCEGDIVQLEVKVSLES-VEGVWMKDGQEV 2395
Query: 2193 PARHQTH------GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPP 2246
+ H +L + +T D+G Y + L S V++ + + P+
Sbjct: 2396 QPSDRVHIVIDKQSHMLLIEDMTKEDAGNYSFTIPALG--LSTSGRVSVYSVDVITPLKD 2453
Query: 2247 VRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG------SRLYIFQ 2300
V V EG L C V+ V WY + +V+ RL I +
Sbjct: 2454 V-------NVIEGTKAVLECKVSVPDVTSVKWYLNDEQIKPDDRVQAIVKGTKQRLVINR 2506
Query: 2301 ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDL 2360
+D G Y + G N S + I+I + +T ++
Sbjct: 2507 THASDEGPY-------------KLIVGRVETNCNL---SVEKIKIIRGLRDLTCTETQNV 2550
Query: 2361 NCVVP-GQSHAQVTWHKRG----GSLPVRHQTHGSLLRL--YQASPADSGEYVCRVLGSS 2413
V S V W+ + S + + HG + +L D G+Y +
Sbjct: 2551 VFEVELSHSGIDVLWNFKDKEIKPSSKYKIEAHGKIYKLTVLNMMKDDEGKY---TFYAG 2607
Query: 2414 VPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKR 2473
+ + L A S P T VAE Q C VA ++ W +
Sbjct: 2608 ENMTSGKLTVAGGAISKPLTDQT-----------VAESQEAVFECEVA-NPDSKGEWLRD 2655
Query: 2474 GGSLPARHQV------HGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGS 2527
G LP + + H RL + D GEY +V S + + V
Sbjct: 2656 GKHLPLTNNIRSESDGHKRRLIIAATKLDDIGEYTYKVATSKTSAKLKV----------- 2704
Query: 2528 HSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHT--ITWYKRGGSLPSRHQIVGS-- 2583
V+I+ + +L T D V P+ + W K G L S + S
Sbjct: 2705 ------EAVKIKKTLKNLTVTETQDAVFTVELTHPNVKGVQWIKNGVVLESNEKYAISVK 2758
Query: 2584 ----RLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSP 2639
LRI D Y G R + + S HV +V I +
Sbjct: 2759 GTIYSLRIKNCAIVDESVY--------GFR----LGRLGASARLHVETVK--IIKKPKDV 2804
Query: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQM-----SVADSGEY 2694
T +E T+ V+ + ++K PS S ++H++ S +D+GEY
Sbjct: 2805 TALENATVAFEVSVSHDTVPVKWFHKSVEIKPSDKHRLVSERKVHKLMLQNISPSDAGEY 2864
Score = 50.1 bits (118), Expect = 5e-05
Identities = 131/657 (19%), Positives = 228/657 (34%), Gaps = 121/657 (18%)
Query: 3089 YRCVASNAYGV------AQSVVNLSVHGPP---TVSVLPEGPV---WVKV---GKAVTLE 3133
+R A N YG+ A + V PP TV + V W K G + ++
Sbjct: 23105 FRVTAENEYGIGLPAQTADPIKVAEVPQPPGKITVDDVTRNSVSLSWTKPEHDGGSKIIQ 23164
Query: 3134 CVSAGEPRSSARWT---RISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNA 3190
+ + + S +W+ R+ S A + T G V+ ++ SD +
Sbjct: 23165 YIVEMQAKHSEKWSECARVKSLQAVITNLTQGEEYLFRVVAVNEKGRSDP--------RS 23216
Query: 3191 LGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRS 3250
L +++++ P V+ + +V+ G + +G P PTI W+K
Sbjct: 23217 LAVPIVAKDLVIE--------PDVKPAFSSYSVQVGQDLKIEVPISGRPKPTITWTKDGL 23268
Query: 3251 PLPWQHR------LEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTV 3304
PL R L+ TL I + D GQY + G A+I + P
Sbjct: 23269 PLKQTTRINVTDSLDLTTLSIKETHKDDGGQYGITVANVVGQKTASIEIVTLDKPDPPKG 23328
Query: 3305 PEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR------------ATARNELLHF 3352
P + E++ L PPL ++ + + + AT L
Sbjct: 23329 PVKFDDVSAESITLS----WNPPLYTGGCQITNYIVQKRDTTTTVWDVVSATVARTTLKV 23384
Query: 3353 ERAAPEDSGRYRCRVTNKVGSAEAFAQ--LLVQ------GPPGSLPATSIPAGSTPTVQV 3404
+ ++R N+ G + A ++ Q GPPG+ AT+I S V
Sbjct: 23385 TKLKTGTEYQFRIFAENRYGQSFALESDPIVAQYPYKEPGPPGTPFATAISKDS----MV 23440
Query: 3405 TPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTY 3464
E + G S + + W K + + D + QNL++ + +
Sbjct: 23441 IQWHEPVNNGGSPVIGYHLERKERNSILWTKVNKTI-----IHDTQFKAQNLEEGIEYEF 23495
Query: 3465 ICQAHG--PWGKAQASAQLVI-------QALPSVLINIRTSVQ-----------TVVVGH 3504
A GKA +++ + P ++ R + +++ G+
Sbjct: 23496 RVYAENIVGVGKASKNSECYVARDPCDPPGTPEPIMVKRNEITLQWTKPVYDGGSMITGY 23555
Query: 3505 AVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAG-- 3562
VE L P W K ++++ ++ + ++R A NAAG
Sbjct: 23556 IVEKRDL------PDGRWMKAS---FTNVIET--QFTVSGLTEDQRYEFRVIAKNAAGAI 23604
Query: 3563 -----TTQSHVLLLVQALPQISMPQEVR----VPAGSAAVFPCIASGYPTPDISWSKLDG 3613
+T LP+ISM + R V AG G P P I W + D
Sbjct: 23605 SKPSDSTGPITAKDEVELPRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDK 23664
Query: 3614 SLPPDSRLE------NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVP 3664
+ +R E +L++ D G Y+ A+N G +++V +R P
Sbjct: 23665 EIEESARCEIKNTDFKALLIVKDAIRIDGGQYILRASNVAGSKSFPVNVKVLDRPGP 23721
Score = 49.7 bits (117), Expect = 6e-05
Identities = 27/85 (31%), Positives = 40/85 (47%), Gaps = 5/85 (5%)
Query: 409 VTPPR-----ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
VTPP +++ G++VT C G P+P + W I S +T + G
Sbjct: 940 VTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIAR 999
Query: 464 LIIRDVKESDQGAYTCEAMNARGMV 488
L+IR+ D G +TC A+N G V
Sbjct: 1000 LMIREAFAEDSGRFTCSAVNEAGTV 1024
Score = 49.7 bits (117), Expect = 6e-05
Identities = 175/867 (20%), Positives = 312/867 (35%), Gaps = 154/867 (17%)
Query: 2890 EYSCQVTGSSGTLEA------SVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLD 2943
E+ + ++G + A +++ E +P + P + + I+A G T+
Sbjct: 20345 EFRIRAKNTAGAISAPSESTETIICKDEYEAPTIVLDPTIKDGLTIKA-------GDTIV 20397
Query: 2944 LNCV-VPGQAHAQVTWYKRGGSLPARHQTH------GSQLRLHLVSPADSGEYVCRAASG 2996
LN + + G+ + +W K G + T S L + + D+GEY A +
Sbjct: 20398 LNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGEYTITATNP 20457
Query: 2997 PGPEQE-ASFTVT-VP----PSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAA 3050
G + E TV VP P E S+ ++ PP ++ G + K I +
Sbjct: 20458 FGTKVEHVKVTVLDVPGPPGPVEISNVSAEKATLTWTPP---LEDG-GSPIKSYILEKRE 20513
Query: 3051 PISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVH- 3109
L W +++++ H++ I G N +R A N YG + V + V
Sbjct: 20514 TSRLLWTVVSEDIQSCRHVATK----LIQG----NEYIFRVSAVNHYGKGEPVQSEPVKM 20565
Query: 3110 ----GPPTVSVLPEGPVWVKV-------------GKAVTLECVSAGEPRSSARWTRISST 3152
GPP PE K G +T V E + S RW R T
Sbjct: 20566 VDRFGPPGPPEKPEVSNVTKNTATVSWKRPVDDGGSEITGYHVERRE-KKSLRWVRAIKT 20624
Query: 3153 PAK-LEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGA 3211
P L + GL + + + + + AG +G + + ++ A P
Sbjct: 20625 PVSDLRCKVTGLQEG-STYEFRVSAENRAG---------IGPPSEASDSVLMKDAAYPPG 20674
Query: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPT---IHWSKLRSPLPWQHRLEGDTL----- 3263
P + T ++ A + G T + K+ W G L
Sbjct: 20675 PPSNPHVTDTTKKSASLAWGKPHYDGGLEITGYVVEHQKVGDEA-WIKDTTGTALRITQF 20733
Query: 3264 IIPRVAQQDSGQYICNATSPAGHAEATIILHVE------SPPYATTVPEHAS--VQAGET 3315
++P + ++ + +A + AG E +I VE +P + + V+AG +
Sbjct: 20734 VVPDLQTKEKYNFRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLS 20793
Query: 3316 VQLQCLAHGTPPLTFQWSRVGSSLPGRATARNE----LLHFERAAPEDSGRYRCRVTNKV 3371
+++ G P W++ +L RA N LL D+G++ + N
Sbjct: 20794 IRIFVPIKGRPAPEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPA 20853
Query: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVP-SDRGTQ 3430
G F + V PG P + + P TK SV H +P D G++
Sbjct: 20854 GKKSGFVNVRVLDTPG------------PVLNLRPTDITKD---SVTLHWDLPLIDGGSR 20898
Query: 3431 LRWFKEGGQLPPGHSVQDG-------VLRIQNLDQSCQGTYICQAHGPWG---KAQASAQ 3480
+ + + S ++ L + C+ + A +G + +
Sbjct: 20899 ITNYIVEKREATRKSYSTATTKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEP 20958
Query: 3481 LVIQALPSV--LINIRTSVQTVVVGHAVEFECLALGDPKPQVT-WSKVGGHL----RPGI 3533
+ PS +NI ++ V +L PKP+ SK+ G++ R G
Sbjct: 20959 VKASEAPSPPDSLNIMDITKSTV----------SLAWPKPKHDGGSKITGYVIEAQRKGS 21008
Query: 3534 VQSGGVVRIAHVE-----LADAGQY--RCTATNAAGTT---QSHVLLLVQ--ALPQISM- 3580
Q + + +E L + +Y + A N+AG + +S +++ + LP++ +
Sbjct: 21009 DQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQTMLPELDLR 21068
Query: 3581 ---PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE------NNMLMLPSV 3631
+ V AG G P P ++W K D L R+ + +L +
Sbjct: 21069 GIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINEC 21128
Query: 3632 RPQDAGTYVCTATNRQGKVKAFAHLQV 3658
D+G Y TA N G+V +QV
Sbjct: 21129 VRSDSGPYPLTARNIVGEVGDVITIQV 21155
Score = 49.7 bits (117), Expect = 6e-05
Identities = 126/548 (22%), Positives = 206/548 (37%), Gaps = 113/548 (20%)
Query: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLI 2012
P V++ V A +++ G P AT+ WRK+G +L R S + +L I
Sbjct: 25395 PSVELPFHTFNVKAREQLKIDVPFKGRPQATVNWRKDGQTLKETTRVNVSSSKTVTSLSI 25454
Query: 2013 PAITTADAGFY-LCVATSPAGTAQARIQVVVLSASDASPPPVKIE---------SSSPSV 2062
+ D G Y LCV+ S AG+ I ++VL P P++I+ S +P
Sbjct: 25455 KEASKEDVGTYELCVSNS-AGSITVPITIIVLD-RPGPPGPIRIDEVSCDSITISWNPPE 25512
Query: 2063 TEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRV--E 2120
+G N +V TW+ ++ +R + V EY RV E
Sbjct: 25513 YDGGCQISNYIVEKKETTSTTWHIVSQAV--------ARTSIKIVRLTTGSEYQFRVCAE 25564
Query: 2121 NGSGP---KEASITVSVLHGTHSGPSYTP-VPGSTRPIRIEPSSSHVAEGQTLDLNCVVP 2176
N G E+S V+ + GP TP V +T+ + V +G + + +
Sbjct: 25565 NRYGKSSYSESSAVVAEYPFSPPGPPGTPKVVHATKSTMLVTWQVPVNDGGSRVIGYHLE 25624
Query: 2177 GQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSG---EYVCHVVGTSGPLEASVLV 2233
+ + + W K L A Q +V+ D G EY + +G + S
Sbjct: 25625 YKERSSILWSKANKILIADTQM--------KVSGLDEGLMYEYRVYAENIAGIGKCS--- 25673
Query: 2234 TIEASVIPGPI-----PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR 2288
S P P PP + E ++ T + + W K
Sbjct: 25674 ---KSCEPVPARDPCDPPGQPEVTNIT---------------RKSVSLKWSK-------P 25708
Query: 2289 HQVRGSRL--YIFQASPADAGQYV-CRASNGMEASITVT-VTGTQ-----------GANL 2333
H G+++ YI + G+++ C +N E VT +T Q ++
Sbjct: 25709 HYDGGAKITGYIVERRELPDGRWLKCNYTNIQETYFEVTELTEDQRYEFRVFARNAADSV 25768
Query: 2334 AYPAGSTQPI----RIEPSSSQ----------VAEGQTLDLNCVVPGQSHAQVTWHKRGG 2379
+ P+ ST PI +EP V G+ L +N + G+ ++W K G
Sbjct: 25769 SEPSESTGPIIVKDDVEPPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGI 25828
Query: 2380 SLPVRHQT------HGSLLRLYQASPADSGEYVC---RVLGS-SVPLEASVL-VTIEPAG 2428
+ R +T + +LL + D+G+YV V G+ SV + VL PAG
Sbjct: 25829 EIEERARTEIISTDNHTLLTVKDCIRRDTGQYVLTLKNVAGTRSVAVNCKVLDKPGPPAG 25888
Query: 2429 SVPALGVT 2436
+ G+T
Sbjct: 25889 PLEINGLT 25896
Score = 49.7 bits (117), Expect = 6e-05
Identities = 52/174 (29%), Positives = 73/174 (41%), Gaps = 13/174 (7%)
Query: 1956 PRVQVS--PERT-QVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIAT 2009
P + +S P++T V AGR V L AG P +W G L R T +A
Sbjct: 29736 PTIDLSTMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAK 29795
Query: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKI-ESSSPSVT---EG 2065
L I T D G Y + GT I+V++L P+KI E + S+T E
Sbjct: 29796 LTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKIDEIDATSITISWEP 29855
Query: 2066 QTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRV 2119
LD ++G Q +R G LP V S + +++ + EYV RV
Sbjct: 29856 PELDGGAPLSGYVVEQRDAHRPGW-LPVSESVTRSTFKFTRLT--EGNEYVFRV 29906
Score = 49.7 bits (117), Expect = 6e-05
Identities = 56/204 (27%), Positives = 87/204 (42%), Gaps = 24/204 (11%)
Query: 2921 PGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA----RHQTHGS-- 2974
P P+Y + +++V E + V + H VTWYK G + + T S
Sbjct: 31690 PEFTLPLYNK--TAYVGENVRFGVTITVHPEPH--VTWYKSGQKIKPGDNDKKYTFESDK 31745
Query: 2975 ---QLRLHLVSPADSGEYVCRAASGPGPEQ-EASFTVTV-PPSEGSSYRLRSPVISIDPP 3029
QL ++ V+ D EY A + G + +A TVT+ PP S+ R P+
Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLR---PMFKRLLA 31802
Query: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELE--DNVHISPNGS---IITIVGTRPS 3084
++ Q+GQ F+ + G P +L+W+ Q L N+ I G + I T P
Sbjct: 31803 NAECQEGQSVCFEIRV-SGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPE 31861
Query: 3085 NHGTYRCVASNAYGVAQSVVNLSV 3108
+ G YR A+N G +L V
Sbjct: 31862 DTGYYRVTATNTAGSTSCQAHLQV 31885
Score = 49.3 bits (116), Expect = 8e-05
Identities = 105/491 (21%), Positives = 184/491 (37%), Gaps = 69/491 (14%)
Query: 3197 QVEVIVDTGAMAPGA-PQVQAEEAE--------------LTVEAGHTATLRCSATGSPAP 3241
++ I D G P P V+ E E L V AG + + G PAP
Sbjct: 20747 RISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAP 20806
Query: 3242 TIHWSKLRSPLPWQHRLEGDT----LIIPRVAQQDSGQYICNATSPAGHAEATIILHVES 3297
+ W+K L + +E LIIP + D+G+++ +PAG + + V
Sbjct: 20807 EVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVLD 20866
Query: 3298 PPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAP 3357
P +++ + + H PL SR+ + + + A + A
Sbjct: 20867 TPGPVL-----NLRPTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYS---TAT 20918
Query: 3358 EDSGRYRCRVTNKVGSAEAFAQLLVQGPPG--SLPATSIPAGSTPTVQVTPQLETKSIGA 3415
+ +VT E F +++ + G T+ P ++ L I
Sbjct: 20919 TKCHKCTYKVTGLSEGCEYFFRVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITK 20978
Query: 3416 S-VEFHCAVPS-DRGTQLRWF------KEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQ 3467
S V P D G+++ + K Q +V+ ++NL + + T+
Sbjct: 20979 STVSLAWPKPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVM 21038
Query: 3468 AHGPWGK-AQASAQLVIQALPSVL--INIRTSVQTVVVGHA---VEFECLALGDPKPQVT 3521
A G+ A ++ VI ++L +++R Q +V+ A ++ E LG PKP VT
Sbjct: 21039 AVNSAGRSAPRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVT 21098
Query: 3522 WSKVGGHLRP------GIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQAL 3575
W K L+ + ++ I +D+G Y TA N G + + V +
Sbjct: 21099 WKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDI 21158
Query: 3576 PQISMPQEVRVPAGSAAVFPCIASGYPTPDISWS--KLDGSLPPDSRLENNMLMLPSVRP 3633
P P F ++S + T SW + DG +P + N ++ +R
Sbjct: 21159 PG---------PPTGPIKFDEVSSDFVT--FSWDPPENDGGVP----ISNYVV---EMRQ 21200
Query: 3634 QDAGTYVCTAT 3644
D+ T+V AT
Sbjct: 21201 TDSTTWVELAT 21211
Score = 48.5 bits (114), Expect = 1e-04
Identities = 30/81 (37%), Positives = 40/81 (49%), Gaps = 1/81 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P ++ PR S + GQ V FTC G P+P I W N I V+++ +L
Sbjct: 33134 PAFISQPR-SQNINEGQNVLFTCEISGEPSPEIEWFKNNLPISISSNVSISRSRNVYSLE 33192
Query: 466 IRDVKESDQGAYTCEAMNARG 486
IR+ SD G YT +A N RG
Sbjct: 33193 IRNASVSDSGKYTIKAKNFRG 33213
Score = 48.1 bits (113), Expect = 2e-04
Identities = 73/335 (21%), Positives = 117/335 (34%), Gaps = 58/335 (17%)
Query: 1853 ATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGG-QLPAKA 1911
ATL + S T SA ++ TV+P +E R A +P P + P + A
Sbjct: 840 ATLQKELSATSSAQKITKSVKAPTVKP---SETRVRAEPTPLPQFPFADTPDTYKSEAGV 896
Query: 1912 QIHGGI-LRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP-ERTQVHA 1969
++ + + + ++ + + + AR V P VS + V
Sbjct: 897 EVKKEVGVSITGTTVREERFEVLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIE 956
Query: 1970 GRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE---RTDIATLLIPAITTADAGFYLCV 2026
G +V L C +G PS T+TW +E + + ++ IA L+I D+G + C
Sbjct: 957 GESVTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCS 1016
Query: 2027 ATSPAGTAQARIQVVV------------------------------------LSASDASP 2050
A + AGT + V L+ A P
Sbjct: 1017 AVNEAGTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGP 1076
Query: 2051 --PPVKIESSSPSV---TEGQTLDLNCVVAGSAHAQVTWYRRGGSLPP--------HTQV 2097
P + P V EG ++ C V G+ V W + G L + Q
Sbjct: 1077 GEPAAPYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQT 1136
Query: 2098 HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITV 2132
+L + D+GEY V N G AS ++
Sbjct: 1137 GECKLVISMTFADDAGEYTIVVRNKHGETSASASL 1171
Score = 48.1 bits (113), Expect = 2e-04
Identities = 53/225 (23%), Positives = 87/225 (38%), Gaps = 34/225 (15%)
Query: 3140 PRSSARWTRISSTPAKLEQRTYGLMDSH-------AVLQISSAKPSDAGTYVCLAQNALG 3192
PR S +W A+ + GL + A+ + ++KPS + A+
Sbjct: 13628 PRGSDKWVACGEPVAETKMEVTGLEEGKWYAYRVKALNRQGASKPSRPTEEI----QAVD 13683
Query: 3193 TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL 3252
T Q+ E+ +D +A LTV+AG L + TG P P I W+K L
Sbjct: 13684 T-QEAPEIFLDVKLLAG-----------LTVKAGTKIELPATVTGKPEPKITWTKADMIL 13731
Query: 3253 PWQHRL------EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE 3306
R+ + T+ I + D+G YI A + G A A + ++V P
Sbjct: 13732 KQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEVNVLDKP-----GP 13786
Query: 3307 HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLH 3351
A+ + CL PP S++ + + R +E+ H
Sbjct: 13787 PAAFDITDVTNESCLLTWNPPRDDGGSKITNYVVERRATDSEVWH 13831
Score = 48.1 bits (113), Expect = 2e-04
Identities = 38/129 (29%), Positives = 58/129 (44%), Gaps = 16/129 (12%)
Query: 3546 ELADAGQY--RCTATNAAGT-----TQSHVLLLVQALPQISMPQEVR----VPAGSAAVF 3594
E+ + Y R +A NAAG TQ + Q P + + V+ + AG
Sbjct: 15065 EIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRI 15124
Query: 3595 PCIASGYPTPDISWSKLDGSLPPDSRLENNM-----LMLPSVRPQDAGTYVCTATNRQGK 3649
P + +G P P W+K +G L D + +N+ L++ +D G YV TATN G
Sbjct: 15125 PAVVTGRPVPTKVWTKEEGELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGS 15184
Query: 3650 VKAFAHLQV 3658
A A ++V
Sbjct: 15185 KFAAARVEV 15193
Score = 48.1 bits (113), Expect = 2e-04
Identities = 42/135 (31%), Positives = 58/135 (42%), Gaps = 22/135 (16%)
Query: 3552 QYRCTATNAAGTTQSHVLLLV-----QALPQISMPQEVR-----VPAGSAAVFPCIASGY 3601
++R A N G ++ + L V + P I + VR V AG P +G
Sbjct: 15366 EFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGL 15425
Query: 3602 PTPDISWSKLDGSL--PPD---------SRLE-NNMLMLPSVRPQDAGTYVCTATNRQGK 3649
P P I WSK + + P D SR E L +P +D GTY TA+NR G
Sbjct: 15426 PMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVTASNRLGS 15485
Query: 3650 VKAFAHLQVPERVVP 3664
V H++V +R P
Sbjct: 15486 VFRNVHVEVYDRPSP 15500
Score = 47.8 bits (112), Expect = 2e-04
Identities = 24/82 (29%), Positives = 36/82 (43%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PPQ + P + GQ+ TF C G P ++W L+ I + + ++ G T
Sbjct: 4860 PPQFIKKPSPVLVLRNGQSTTFECQITGTPKIRVSWYLDGNEITAIQKHGISFIDGLATF 4919
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
I + + G Y CEA N G
Sbjct: 4920 QISGARVENSGTYVCEARNDAG 4941
Score = 47.8 bits (112), Expect = 2e-04
Identities = 39/145 (26%), Positives = 66/145 (45%), Gaps = 13/145 (8%)
Query: 1926 TDQAQYLCR--AHSSAGQ-----QVARAVLHVHGGGGPRVQVSPERTQV---HAGRTVRL 1975
T +QY R A ++ G +V + + GGP + + E T+V AG +V+L
Sbjct: 26833 TQNSQYEFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKL 26892
Query: 1976 YCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITTADAGFYLCVATSPAG 2032
+G P+ TI W K+ L A TD+A++LI ++G Y + G
Sbjct: 26893 RAGISGKPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMG 26952
Query: 2033 TAQARIQVVVLSASDASPPPVKIES 2057
+A A I+V +L P++ ++
Sbjct: 26953 SASATIRVQILDKPGPPGGPIEFKT 26977
Score = 47.8 bits (112), Expect = 2e-04
Identities = 125/628 (19%), Positives = 217/628 (34%), Gaps = 127/628 (20%)
Query: 2883 VSPADSGEYSCQVTGSSGTLE-----ASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
+SP D E+ + GT+ + +++T + + P PI G P Y + +
Sbjct: 27918 LSPGDRYEFRIIARNAVGTISPPSQSSGIIMTRDENVP-PIVEFG---PEYFDGLI--IK 27971
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH------GSQLRLHLVSPADSGEYVC 2991
G++L + +V G+ +VTW+K G + R + L + + G Y
Sbjct: 27972 SGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTSLFVRDATRDHRGVYTV 28031
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAP 3051
A + G +A V V + G ++ P+ + + DA ++DG AP
Sbjct: 28032 EAKNASG-SAKAEIKVKVQDTPG---KVVGPIRFTNITGEKMTLWWDAP----LNDGCAP 28083
Query: 3052 IS-----------LEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVA 3100
I+ L W +ED +I I G N +R A N +GV
Sbjct: 28084 ITHYIIEKRETSRLAWAL----IEDKCEAQSYTAIKLING----NEYQFRVSAVNKFGVG 28135
Query: 3101 QS-----VVNLSVHGPPTVSVLPEGP---------VWVKV---GKAVTLECVSAGEPRSS 3143
+ VV + P +PE W + G + + + + S
Sbjct: 28136 RPLDSDPVVAQIQYTVPDAPGIPEPSNITGNSITLTWARPESDGGSEIQQYILERREKKS 28195
Query: 3144 ARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVD 3203
RW ++ S E R +++ + + +A+NA G
Sbjct: 28196 TRWVKVISKRPISETR----------FKVTGLTEGNEYEFHVMAENAAGVGP-------- 28237
Query: 3204 TGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK---------------- 3247
A G ++ + E G ++ + T ++ WSK
Sbjct: 28238 ----ASGISRL-IKCREPVNPPGPPTVVKVTDTSKTTVSLEWSKPVFDGGMEIIGYIIEM 28292
Query: 3248 LRSPLPWQHRLEGDTLIIPRVAQQD-----SGQYICNATSPAGHAEATIILHVESPPYAT 3302
++ L H++ + + R D ++ +A + AG ++ +
Sbjct: 28293 CKADLGDWHKVNAEACVKTRYTVTDLQAGEEYKFRVSAINGAGKGDSCEVTGTIKAVDRL 28352
Query: 3303 TVPE----------HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA----TARNE 3348
T PE H V+AG +++L G P T WS+ S+L RA T
Sbjct: 28353 TAPELDIDANFKQTHV-VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFS 28411
Query: 3349 LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLV---QGPPGSLPATSIPAGSTPTVQVT 3405
L E D+G+Y V N GS + V GPPG + + GS +
Sbjct: 28412 TLTVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDA 28471
Query: 3406 PQLETKSIGASVEFHCAVPSDRGTQLRW 3433
P L+ G + H V ++ W
Sbjct: 28472 PLLD----GGARIHHYVVEKREASRRSW 28495
Score = 47.8 bits (112), Expect = 2e-04
Identities = 131/625 (20%), Positives = 223/625 (35%), Gaps = 95/625 (15%)
Query: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPH----TQVHGSRLRLPQVSPADSGEYV 2116
++ G +L L V+G +TW ++G L T S L + +V+ D+G+Y
Sbjct: 29457 TIRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYT 29516
Query: 2117 CRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRI----------EPSSSHVAEG 2166
EN SG K A++ V V PS S + I P ++++ E
Sbjct: 29517 IEAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVTITWEIPTIDGGAPVNNYIVEK 29576
Query: 2167 QTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGP 2226
+ + T ++ G + + +V P ++ G P
Sbjct: 29577 REAAMRAFKTVTTKCSKTLYRISGLVE-------GTMYYFRVLPE-------NIYGIGEP 29622
Query: 2227 LEASVLVTI-EASVIPGPIPPVRIESSSSTVA------EGQTLDLSCVVAGQAHAQVTWY 2279
E S V + E ++P + V + S+ T+A +G + V+ W
Sbjct: 29623 CETSDAVLVSEVPLVPAKLEVVDVTKSTVTLAWEKPLYDGGSRLTGYVLEACKAGTERWM 29682
Query: 2280 KRGGSLPA--RHQVRGSRLYIFQASPADAGQYVCRASNGMEASI-----TVTVTGTQGAN 2332
K P H V S + QY+ R E + TVT Q
Sbjct: 29683 KVVTLKPTVLEHTV---------TSLNEGEQYLFRIRAQNEKGVSEPRETVTAVTVQDLR 29733
Query: 2333 LAYPAG-STQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL------PVRH 2385
+ ST P + V G+ ++L + G+ +W G L V
Sbjct: 29734 VLPTIDLSTMP----QKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVET 29789
Query: 2386 QTHGSLLRLYQASPADSGEYVCRVLG-SSVPLEASVLVTIEPAGSVPALGVTPTVRIESS 2444
T + L + + + D+GEY + + E ++ ++ G P G I+++
Sbjct: 29790 HTKVAKLTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPG--PPTGPIKIDEIDAT 29847
Query: 2445 SSQVA-EGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVC 2503
S ++ E LD ++G Q H R G LP V S + ++T + EYV
Sbjct: 29848 SITISWEPPELDGGAPLSGYVVEQRDAH-RPGWLPVSESVTRSTFKFTRLT--EGNEYVF 29904
Query: 2504 RVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPH 2563
RV + T + GS+ Q IE S+ G L S+
Sbjct: 29905 RV---AATNRFGI---------GSYLQSEV----IECRSSIRIPGPPETLQIFDVSRDGM 29948
Query: 2564 TITWY---KRGGS-----LPSRHQIVGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLI 2614
T+TWY GGS + R ++ R +R+ +V + ++ G
Sbjct: 29949 TLTWYPPEDDGGSQVTGYIVERKEVRADRWVRVNKVPVTMTRYRSTGLTEGLEYEHRVTA 30008
Query: 2615 VTIQGSGSSHVPSVSPPIRIESSSP 2639
+ +GSG PS P + ++ +P
Sbjct: 30009 INARGSGKPSRPS-KPIVAMDPIAP 30032
Score = 47.8 bits (112), Expect = 2e-04
Identities = 54/204 (26%), Positives = 76/204 (37%), Gaps = 16/204 (7%)
Query: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQG----TATLHVQASGTLSAPVVSIHPPQLTVQPG 1880
LTI +V D Y N + D T TLH + + P+ Q G
Sbjct: 31750 LTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHPPPTDSTLRPMFKRLLANAECQEG 31809
Query: 1881 QLAEFRCSATGSPTPTLEW--TGGPGGQLPAKAQIHGGI----LRLPAVEPTDQAQYLCR 1934
Q F +G P PTL+W G P P IH G+ L + P D Y
Sbjct: 31810 QSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVT 31869
Query: 1935 AHSSAGQQVARAVLHVHGGGGPRVQV-SPERTQVHAGRTVRLYCRAAGVPSATITWRKEG 1993
A ++AG +A L V + + S E + H + + R A + S T E
Sbjct: 31870 ATNTAGSTSCQAHLQVERLRYKKQEFKSKEEHERHVQKQIDKTLRMAEILSGT-----ES 31924
Query: 1994 GSLPPQARSERTDIATLLIPAITT 2017
L A+ + A L PA++T
Sbjct: 31925 VPLTQVAKEALREAAVLYKPAVST 31948
Score = 47.4 bits (111), Expect = 3e-04
Identities = 89/399 (22%), Positives = 150/399 (37%), Gaps = 56/399 (14%)
Query: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ------LRLHLVSPADSGEY 2989
V GQT+ + V G+ +TW K G L + Q L++ AD G+Y
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRVELQIKEAVRADHGKY 17979
Query: 2990 VCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGA 3049
+ A + G Q S V V G L+ V ++ + T+ S++ + +G
Sbjct: 17980 IISAKNSSGHAQ-GSAIVNVLDRPGPCQNLK--VTNVTKENCTI------SWENPLDNGG 18030
Query: 3050 APIS---LEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNL 3106
+ I+ +E++ NQ+ V +I +N +R A N GV ++
Sbjct: 18031 SEITNFIVEYRKPNQKGWSIVASDVTKRLIK-ANLLANNEYYFRVCAENKVGVGPTIETK 18089
Query: 3107 SVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRIS------STPAKLEQRT 3160
+ P +++ P + G+ L G+ +W R + +E+R
Sbjct: 18090 T----PILAINPID----RPGEPENLHIADKGKTFVYLKWRRPDYDGGSPNLSYHVERRL 18141
Query: 3161 YGLMDSHAVLQISSAKPSDAGTYVCL----------AQNALGTAQ--KQVEVIVDTGAMA 3208
G D V + S K + C+ +N G + K EV+V
Sbjct: 18142 KGSDDWERVHK-GSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVVKEDLQK 18200
Query: 3209 PGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK-------LRSP-LPWQHRLEG 3260
P + LTV+AG T L G P P + W+K RSP + R +
Sbjct: 18201 PVLDLKLS--GVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADS 18258
Query: 3261 DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPP 3299
+ + + D G+Y+ AT+ AG A ++V P
Sbjct: 18259 SKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKP 18297
Score = 47.0 bits (110), Expect = 4e-04
Identities = 120/571 (21%), Positives = 199/571 (34%), Gaps = 82/571 (14%)
Query: 2050 PPPVKIESSSPS---VTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPP------HTQVHGS 2100
PP V+++ V G T+ ++ G W G + T S
Sbjct: 17507 PPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSS 17566
Query: 2101 RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLH--GTHSGP-SYTPVPGSTRPIRIE 2157
L + D+GEY V N +G K ++ ++VL G +GP + V I +
Sbjct: 17567 VLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQ 17626
Query: 2158 PSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSG-EY 2216
P +G + +N +V Q + TW + GS ++ G EY
Sbjct: 17627 PPKD---DGGSPVINYIVEKQDTRKDTWGV---------VSSGSSKTKLKIPHLQKGCEY 17674
Query: 2217 VCHV-----VGTSGPLEASVLVTIEASVIPGPI-PPVRIESSSSTVAEGQTLDLSCVVAG 2270
V V +G PL+++ V P P PV + + + TL S
Sbjct: 17675 VFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATVSWTLPKS----- 17729
Query: 2271 QAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQG 2330
+ +T Y R +V G + + + AD V G V G
Sbjct: 17730 DGGSPITGYYM-----ERREVTGKWVRVNKTPIADLKFRVTGLYEGNTYEFRVFAENLAG 17784
Query: 2331 ANLAYPAGSTQPIR-----------IEPS-------------SSQVAEGQTLDLNCVVPG 2366
L+ P+ S+ PI+ I P + +++G + L VV
Sbjct: 17785 --LSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVEC 17842
Query: 2367 QSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEP 2426
Q W++ +R Q + L + + ++G P E + V +
Sbjct: 17843 QKPGTAQWNRINKDELIR-QCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKD 17901
Query: 2427 AGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH-- 2484
P + + T R V GQT+ + V G+ +TW K G L +V
Sbjct: 17902 ILHPPEVELDVTCR---DVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLI 17958
Query: 2485 ----GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIES 2540
L++ + AD G+Y+ SSG + S +V + R + V V E+
Sbjct: 17959 QDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGPCQNLKVT-NVTKEN 18017
Query: 2541 SSAS----LANGHTLDLNCLVASQAPHTITW 2567
+ S L NG + N +V + P+ W
Sbjct: 18018 CTISWENPLDNGGSEITNFIVEYRKPNQKGW 18048
Score = 47.0 bits (110), Expect = 4e-04
Identities = 178/876 (20%), Positives = 303/876 (34%), Gaps = 138/876 (15%)
Query: 2545 LANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI------VGSRLRIPQVTPADSGEY 2598
L G T+ L V + P ITW K +L R + + LR V D+G+Y
Sbjct: 19705 LRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKY 19764
Query: 2599 VCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESS----SPTVVEGQTLDLNCVVA 2654
+ + N G +E +++V + + V I +S+ P +++G + +N VV
Sbjct: 19765 ILTLENSCGKKEYTIVVKVLDTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINYVVQ 19824
Query: 2655 RQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCR--ANNNI---DALEASI 2709
++ +W S T S ++ + Y R A N D E
Sbjct: 19825 KRDAERKSW--------STVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETRD 19876
Query: 2710 VISVSPSAGSPSAPGSSMPIRIESSSSHV-------AEGETLDLNCVVPGQAHAQVTWHK 2762
+ S + G P + +R S SS ++G + + VV W +
Sbjct: 19877 AVKASQTPG----PVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEEN-KWQR 19931
Query: 2763 RGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVM-----GSSGPLEASVLVTIEASGSSA 2817
SL + + + EY RV G P E +V+ +
Sbjct: 19932 VMKSLSLQYSAKDL---------TEGKEYTFRVSAENENGEGTPSEITVVARDDVV---- 19978
Query: 2818 VHVPAPGGAPPIRIE--PSSSRVA-EGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH 2874
AP + ++ P +A E LK + G+ V+W K L +V
Sbjct: 19979 --------APDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVS 20030
Query: 2875 GPLLRLNQV------SPADSGEYSCQVTGSSGTLEASVLVTI--EPSSP-GPIPAPGLAQ 2925
+N +D+G+Y+ + +GT E ++ + + +P P GPI +
Sbjct: 20031 VESSAVNTTLIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGIPTGPIKFDEVTA 20090
Query: 2926 PIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPAD 2985
+ +G + N ++ + W ++ +T RLH +
Sbjct: 20091 EAMTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAV---QKTTFRVTRLH-----E 20142
Query: 2986 SGEYVCRAAS----GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDA-- 3039
EY R ++ G G ++ V P + V PP + V D+
Sbjct: 20143 GMEYTFRVSAENKYGVGEGLKSEPIVARHPFD---------VPDAPPPPNIVDVRHDSVS 20193
Query: 3040 -SFKCLIHDGAAPIS---LEWKTRNQELEDNVHISP-NGSIITIVGTRPSNHGTYRCVAS 3094
++ G +PI+ LE+K RN L + +P + G +R +A
Sbjct: 20194 LTWTDPKKTGGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAI 20253
Query: 3095 NAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSA--------GEPRSSARW 3146
N GV + S+ P V++ P P +T V+ G + +
Sbjct: 20254 NLAGVGKP----SLPSEPVVALDPIDPPGKPEVINITRNSVTLIWTEPKYDGGHKLTGYI 20309
Query: 3147 TRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVE----VIV 3202
P+K + + ++ + A+N G E +I
Sbjct: 20310 VEKRDLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIIC 20369
Query: 3203 DTGAMAPGAPQVQAEEAELTVEAGHTATLRC-SATGSPAPTIHWSKLRSPLPWQHRLE-- 3259
AP + LT++AG T L S G P P WSK + +
Sbjct: 20370 KDEYEAPTIVLDPTIKDGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQIT 20429
Query: 3260 ----GDTLIIPRVAQQDSGQYICNATSPAG----HAEATIILHVESPPYATTVPEHASVQ 3311
L I ++D+G+Y AT+P G H + T +L V PP + ++ +
Sbjct: 20430 STPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVT-VLDVPGPPGPVEISNVSAEK 20488
Query: 3312 AGETVQLQCLAHGTPPLTFQWSRVGS-SLPGRATAR 3346
A T TPPL S + S L R T+R
Sbjct: 20489 ATLT--------WTPPLEDGGSPIKSYILEKRETSR 20516
Score = 46.6 bits (109), Expect = 5e-04
Identities = 130/639 (20%), Positives = 214/639 (33%), Gaps = 78/639 (12%)
Query: 1696 LRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPS---DAGVYICTCRNLH 1752
L C+VS P W + D + +G + +Q + DAG Y C +
Sbjct: 12482 LVCEVS-KPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPSSR 12540
Query: 1753 QSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR---- 1808
+ L E SKP + + E G F+C+ +S + + W R
Sbjct: 12541 TDGKVKVHELAAEFISKPQNLEILE--------GEKAEFVCSISKES--FPVQWKRDDKT 12590
Query: 1809 LHNG-KLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPV 1867
L +G K A +L +++ L D GTYV M + A L V + P+
Sbjct: 12591 LESGDKYDVIADGKKRVLVVKDATLQDMGTYVV----MVGAARAAAHLTVIEKLRIVVPL 12646
Query: 1868 VSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQI-----HGGILRLPA 1922
V+ Q F C + +W + I LR+
Sbjct: 12647 -----KDTRVKEQQEVVFNCE-VNTEGAKAKWFRNEEAIFDSSKYIILQKDLVYTLRIRD 12700
Query: 1923 VEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGV 1982
DQA Y + G+ V A + R+ + + ++V +C+ +
Sbjct: 12701 AHLDDQANYNVSLTNHRGENVKSAANLIVEEEDLRIVEPLKDIETMEKKSVTFWCKVNRL 12760
Query: 1983 PSATITWRKEGGSLPPQAR-SERTD--IATLLIPAITTADAGFYLCVATSPAGTAQARIQ 2039
+ T+ W K G +P R S R D L I D G Y+ AG ++ +
Sbjct: 12761 -NVTLKWTKNGEEVPFDNRVSYRVDKYKHMLTIKDCGFPDEGEYIVT----AGQDKSVAE 12815
Query: 2040 VVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPP----HT 2095
++++ A P +VTE +C ++ A V WYR G +
Sbjct: 12816 LLIIEA----PTEFVEHLEDQTVTEFDDAVFSCQLS-REKANVKWYRNGREIKEGKKYKF 12870
Query: 2096 QVHGS--RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRP 2153
+ GS RL + D EY C VE+ + + PG+
Sbjct: 12871 EKDGSIHRLIIKDCRLDDECEYACGVEDRKSRARLFVEEIPVEIIRPPQDILEAPGADVV 12930
Query: 2154 IRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADS 2213
E + V + VV G H ++ K H+ L++ + P D
Sbjct: 12931 FLAELNKDKVEVQWLRNNMVVVQGDKHQMMSEGK-------IHR-----LQICDIKPRDQ 12978
Query: 2214 GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAH 2273
GEY + EA + + A+ P ++ V G+ L +
Sbjct: 12979 GEYRF----IAKDKEARAKLELAAA------PKIKTADQDLVVDVGKPLTMVVPYDAYPK 13028
Query: 2274 AQVTWYKRGGSLPAR---HQVRGSRLYIFQASPADAGQY 2309
A+ W+K L + + I +A D G+Y
Sbjct: 13029 AEAEWFKENEPLSTKTIDTTAEQTSFRILEAKKGDKGRY 13067
Score = 46.2 bits (108), Expect = 7e-04
Identities = 47/181 (25%), Positives = 79/181 (43%), Gaps = 17/181 (9%)
Query: 3414 GASVEFHCAVPSDRGTQLRWFKEGGQLP----PGHSVQ--DG--VLRIQNLDQSCQGTYI 3465
G++ F + ++ WF++G + PG + DG L I + ++ G Y
Sbjct: 20 GSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSGRYS 79
Query: 3466 CQAHGPWGKAQASAQLVIQA--LPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWS 3523
+A G+A ++A+L+++A P + R TV G V + G P P V +
Sbjct: 80 LKATNGSGQATSTAELLVKAETAPPNFVQ-RLQSMTVRQGSQVRLQVRVTGIPTPVVKFY 138
Query: 3524 KVGGHLRPG----IVQSGGV--VRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ 3577
+ G ++ I Q G + + IA D+G Y ATN+ G S LLVQ +
Sbjct: 139 RDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRATSTAELLVQGEEE 198
Query: 3578 I 3578
+
Sbjct: 199 V 199
Score = 46.2 bits (108), Expect = 7e-04
Identities = 79/388 (20%), Positives = 139/388 (35%), Gaps = 70/388 (18%)
Query: 1779 RSQSVRPGADVTFICTAKSKSPAYTLVW----TRLHNGKLPTRAMDF----NGILTIRNV 1830
++ + G VTF C S P + W R+ +G+ MDF L I V
Sbjct: 1298 KNYRILEGMGVTFHCKM-SGYPLPKIAWYKDGKRIKHGE--RYQMDFLQDGRASLRIPVV 1354
Query: 1831 QLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAP-----------VVSIHPPQLTVQP 1879
D G Y SN+ + L+V+ + L AP + S+ P ++ P
Sbjct: 1355 LPEDEGIYTAFASNIKGNAICSGKLYVEPAAPLGAPTYIPTLEPVSRIRSLSPRSVSRSP 1414
Query: 1880 GQLAEFRCS-ATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSS 1938
+++ R S A SP PG +L E TD++Q L R +
Sbjct: 1415 IRMSPARMSPARMSPARMSPARMSPGRRL----------------EETDESQ-LERLYK- 1456
Query: 1939 AGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL-- 1996
P + P + G+T R + G P W +G +
Sbjct: 1457 -----------------PVFVLKPVSFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVN 1499
Query: 1997 --PPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVK 2054
+ + +L+I T +D+G + VA + AG + + + V + P
Sbjct: 1500 DYTHKVVIKEDGTQSLIIVPATPSDSGEWTVVAQNRAGRSSISVILTVEAVEHQVKPMFV 1559
Query: 2055 IESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPH----TQVHGSR----LRLPQ 2106
+ + ++ EG L++ G+ + + W + + PH ++ G++ L++
Sbjct: 1560 EKLKNVNIKEGSRLEMKVRATGNPNPDIVWLKNSDIIVPHKYPKIRIEGTKGEAALKIDS 1619
Query: 2107 VSPADSGEYVCRVENGSGPKEASITVSV 2134
DS Y N +G V+V
Sbjct: 1620 TVSQDSAWYTATAINKAGRDTTRCKVNV 1647
Score = 46.2 bits (108), Expect = 7e-04
Identities = 38/145 (26%), Positives = 55/145 (37%), Gaps = 27/145 (18%)
Query: 1963 ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERT--------------DIA 2008
E +V G V + + GVP T+TW K PP+ + D
Sbjct: 16124 EFMEVEEGTNVNIVAKIKGVPFPTLTWFKA----PPKKPDNKEPVLYDTHVNKLVVDDTC 16179
Query: 2009 TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSS--------- 2059
TL+IP +D G Y A + GTA +++ VL P+K ES S
Sbjct: 16180 TLVIPQSRRSDTGLYTITAVNNLGTASKEMRLNVLGRPGPPVGPIKFESVSADQMTLSWF 16239
Query: 2060 PSVTEGQTLDLNCVVAGSAHAQVTW 2084
P +G + N V+ + TW
Sbjct: 16240 PPKDDGGSKITNYVIEKREANRKTW 16264
Score = 46.2 bits (108), Expect = 7e-04
Identities = 163/833 (19%), Positives = 274/833 (32%), Gaps = 151/833 (18%)
Query: 2644 GQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH----GSHLRLHQMSVADSGEYVCRAN 2699
G TL L+ ++ P +TW K P++ + GS L + + D G Y
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVE 17292
Query: 2700 NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLD------LNCVVPGQ 2753
N + S+ + V G P S I S ++ E LD N VV +
Sbjct: 17293 NPAGSKTVSVKVLVLDKPGPPRDLEVS---EIRKDSCYLTWKEPLDDGGSVITNYVVERR 17349
Query: 2754 AHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSG-EYVCRVMGSSGPLEASVLVTIEA 2812
A W + S+ + H + G +Y+ RV + +
Sbjct: 17350 DVASAQWSPLSAT---------SKKKSHFAKHLNEGNQYLFRVAAEN-----------QY 17389
Query: 2813 SGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHK--RGGNLPAR 2870
V P P I+ G DL V + + W+K R G P
Sbjct: 17390 GRGPFVETPKP-------IKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSP-- 17440
Query: 2871 HQVHGPLLRLNQVSPADSGEYS------CQVTGSSGTLEASVLVTIE-------PSSPGP 2917
+ G L+ + D ++ C VTG V E P + P
Sbjct: 17441 --ITGYLVEYQEEGTQDWIKFKTVTNLECVVTGLQQGKTYRFRVKAENIVGLGLPDTTIP 17498
Query: 2918 IPAPGLAQPIYIEASSSH-----VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA-RHQT 2971
I P +E V G T+ ++ G W G + H T
Sbjct: 17499 IECQEKLVPPSVELDVKLIEGLVVKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYT 17558
Query: 2972 -----HGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV----PPSEGSSYRLRSP 3022
S L + D+GEY ++ G + A + PP+ +
Sbjct: 17559 VETDNFSSVLTIKNCLRRDTGEYQITVSNAAGSKTVAVHLTVLDVPGPPTGPIN------ 17612
Query: 3023 VISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTR 3082
++ + P T+ S++ DG +P+ + +D + +GS T +
Sbjct: 17613 ILDVTPEHMTI------SWQPPKDDGGSPVINYIVEKQDTRKDTWGVVSSGSSKTKLKIP 17666
Query: 3083 PSNHG---TYRCVASNAYGVA---QSVVNLSVH--------GPPTVSVLPEGPVWVKVGK 3128
G +R A N GV S ++ H G P V+ + E V
Sbjct: 17667 HLQKGCEYVFRVRAENKIGVGPPLDSTPTVAKHKFSPPSPPGKPVVTDITENAATV---- 17722
Query: 3129 AVTLECVSAGEPRS---------SARWTRISSTP-AKLEQRTYGLMDSHAVLQISSAKPS 3178
+ TL G P + + +W R++ TP A L+ R GL + +
Sbjct: 17723 SWTLPKSDGGSPITGYYMERREVTGKWVRVNKTPIADLKFRVTGLYEGNTY--------- 17773
Query: 3179 DAGTYVCLAQNALGTAQKQV--EVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT 3236
+ A+N G ++ + I + P P + + + + E + +
Sbjct: 17774 ---EFRVFAENLAGLSKPSPSSDPIKACRPIKPPGPPINPKLKDKSRETADLVWTKPLSD 17830
Query: 3237 GSPAPTIHWSKLRSPLPWQ-HRLEGDTLI------IPRVAQQDSGQYICNATSPAGHAE- 3288
G + + + P Q +R+ D LI +P + + + ++ A + G E
Sbjct: 17831 GGSPILGYVVECQKPGTAQWNRINKDELIRQCAFRVPGLIEGNEYRFRIKAANIVGEGEP 17890
Query: 3289 --------ATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL- 3339
A ILH T + +V+ G+T+++ G P W++ G L
Sbjct: 17891 RELAESVIAKDILHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLV 17950
Query: 3340 -PGRATARNEL----LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG 3387
R +L L + A D G+Y N G A+ A + V PG
Sbjct: 17951 REKRVDLIQDLPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPG 18003
Score = 46.2 bits (108), Expect = 7e-04
Identities = 49/249 (19%), Positives = 100/249 (40%), Gaps = 29/249 (11%)
Query: 1671 ETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSE 1730
E + AP + P + +G + C++SG P W + + P+ + S
Sbjct: 33129 ELSDAPAFIS-QPRSQNINEGQNVLFTCEISGEPSPEIEWFKNN-LPISISSNVSISRSR 33186
Query: 1731 ----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLV---TEAPSKPITVTVEEQRS--- 1780
L + SD+G Y +N ++ A L+V E PS+ + + S
Sbjct: 33187 NVYSLEIRNASVSDSGKYTIKAKNFRGQCSATASLMVLPLVEEPSREVVLRTSGDTSLQG 33246
Query: 1781 ----QSVRPGA---DVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLS 1833
QSV+ A + +F + S + + T ++ +M + +++ +
Sbjct: 33247 SFSSQSVQMSASKQEASFSSFSSSSASSMT---------EMKFASMSAQSMSSMQESFVE 33297
Query: 1834 DAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSP 1893
+ + SNM ++ T+ + ++A P + P +++ G++ C+ TG P
Sbjct: 33298 MSSSSFMGISNMTQLESSTSKM-LKAGIRGIPPKIEALPSDISIDEGKVLTVACAFTGEP 33356
Query: 1894 TPTLEWTGG 1902
TP + W+ G
Sbjct: 33357 TPEVTWSCG 33365
Score = 45.8 bits (107), Expect = 0.001
Identities = 48/178 (26%), Positives = 76/178 (42%), Gaps = 25/178 (14%)
Query: 2062 VTEGQTLDLNCVVAGSAHAQVTWYRRGG----SLPPHTQVHGS----RLRLPQVSPADSG 2113
V EG T ++G +V+W+R G S P Q+ S +L +P V+ A+SG
Sbjct: 17 VLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKANSG 76
Query: 2114 EYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNC 2173
Y + NGSG +A+ T +L + P P + ++ S V +G + L
Sbjct: 77 RYSLKATNGSG--QATSTAELLVKAETAP-----PNFVQRLQ----SMTVRQGSQVRLQV 125
Query: 2174 VVPGQAHAQVTWHKRG----GSLPARHQTHGSL--LRLHQVTPADSGEYVCHVVGTSG 2225
V G V +++ G SL + G L L + + P DSG Y + + G
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVG 183
Score = 45.8 bits (107), Expect = 0.001
Identities = 31/93 (33%), Positives = 40/93 (43%), Gaps = 9/93 (9%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
IQ G+T+ V G P P W G + RV + + G + LII+D D G
Sbjct: 15114 IQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELDKD-RVVIDNVGTKSELIIKDALRKDHG 15172
Query: 476 AYTCEAMN--------ARGMVFGIPDGVLELVP 500
Y A N AR VF +P VL+L P
Sbjct: 15173 RYVITATNSCGSKFAAARVEVFDVPGPVLDLKP 15205
Score = 45.4 bits (106), Expect = 0.001
Identities = 32/99 (32%), Positives = 44/99 (44%), Gaps = 11/99 (11%)
Query: 3576 PQISMP-QEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE---------NNM 3625
P + P Q V V GS A F SG+P P++SW + DG + S L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFR-DGQVISTSTLPGVQISFSDGRAK 64
Query: 3626 LMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVP 3664
L +P+V ++G Y ATN G+ + A L V P
Sbjct: 65 LTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAP 103
Score = 45.4 bits (106), Expect = 0.001
Identities = 30/92 (32%), Positives = 45/92 (48%), Gaps = 5/92 (5%)
Query: 1963 ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDI-ATLLIPAITTADAG 2021
+R VHAG +R+ +G P T+TW +LP +A E T I ++++I + G
Sbjct: 16532 DRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQG 16591
Query: 2022 FYLCVATSPAGTAQARIQVVVLSASDASPPPV 2053
Y +A + AG + I V VL P PV
Sbjct: 16592 VYSLLAKNEAGERKKTIIVDVLDV----PGPV 16619
Score = 45.4 bits (106), Expect = 0.001
Identities = 154/779 (19%), Positives = 263/779 (33%), Gaps = 104/779 (13%)
Query: 2583 SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVV 2642
S L I T D+GEY +N G++ + VT+ VP P+ I + S
Sbjct: 20435 SMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVLD-----VPGPPGPVEISNVSAE-- 20487
Query: 2643 EGQTLDLNCVVARQPQAIITW---YKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCR-- 2697
+A +TW + GGS + +V CR
Sbjct: 20488 ---------------KATLTWTPPLEDGGSPIKSYILEKRETSRLLWTVVSEDIQSCRHV 20532
Query: 2698 ANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQ 2757
A I E +S G P S P+++ E +++ V A
Sbjct: 20533 ATKLIQGNEYIFRVSAVNHYGK-GEPVQSEPVKMVDRFGPPGPPEKPEVSNVTKNTA--T 20589
Query: 2758 VTWHKR----GGSLPSHHQTRGSRLRLHHVSPADS--GEYVCRVMGS----------SGP 2801
V+W + G + +H R + L V + + C+V G S
Sbjct: 20590 VSWKRPVDDGGSEITGYHVERREKKSLRWVRAIKTPVSDLRCKVTGLQEGSTYEFRVSAE 20649
Query: 2802 LEASVLVTIEASGS----SAVHVPAPGGAPPIR-IEPSSSRVAEGQT-LDLKCVVPGQAH 2855
A + EAS S A + P P P + S+ +A G+ D + G
Sbjct: 20650 NRAGIGPPSEASDSVLMKDAAYPPGPPSNPHVTDTTKKSASLAWGKPHYDGGLEITGY-- 20707
Query: 2856 AQVTWHKRGGNLPARHQVHGPLLRLNQVSPAD---SGEYSCQVTG--SSGTLEASVLVTI 2910
V H++ G+ G LR+ Q D +Y+ +++ +G E +V+ +
Sbjct: 20708 --VVEHQKVGDEAWIKDTTGTALRITQFVVPDLQTKEKYNFRISAINDAGVGEPAVIPDV 20765
Query: 2911 EPSSPGPIPAPGLAQPIYIEASSSH---VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2967
E I +A ++A V G ++ + + G+ +VTW K +L
Sbjct: 20766 E------IVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPAPEVTWTKDNINLKN 20819
Query: 2968 RHQTHGSQLRLHLVSPA----DSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPV 3023
R ++ L+ P D+G++V P ++ V V + G LR
Sbjct: 20820 RANIENTESFTLLIIPECNRYDTGKFVM-TIENPAGKKSGFVNVRVLDTPGPVLNLR--- 20875
Query: 3024 ISIDPPSSTVQQGQDASFKCLIHDGAAPIS---LEWKTRNQELEDNVHISPNGSIITIVG 3080
P+ + + + DG + I+ +E + ++ + + G
Sbjct: 20876 -----PTDITKDSVTLHWDLPLIDGGSRITNYIVEKREATRKSYSTATTKCHKCTYKVTG 20930
Query: 3081 TRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEP 3140
+R +A N YG+ + P S P P + + +T VS P
Sbjct: 20931 LSEGCEYFFRVMAENEYGIGEPTETTE---PVKASEAPSPPDSLNI-MDITKSTVSLAWP 20986
Query: 3141 R------SSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTA 3194
+ S I + +Q T+ + + + T+ +A N+ G +
Sbjct: 20987 KPKHDGGSKITGYVIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRS 21046
Query: 3195 --QKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL 3252
++ VIV M P + + +AG + G P PT+ W K L
Sbjct: 21047 APRESRPVIVKEQTMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQIL 21106
Query: 3253 PWQHRLEGDT------LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP 3305
R+ +T L I + DSG Y A + G I + V P T P
Sbjct: 21107 KQTQRVNFETTATSTILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGP 21165
Score = 45.4 bits (106), Expect = 0.001
Identities = 32/98 (32%), Positives = 45/98 (45%), Gaps = 1/98 (1%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLI-PAITTADAGFYLC 2025
+ AG ++RL +G P ITW K+G L +A + T+ +LLI + DAG Y
Sbjct: 29458 IRAGASLRLMVSVSGRPPPVITWSKQGIDLASRAIIDTTESYSLLIVDKVNRYDAGKYTI 29517
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT 2063
A + +G A + V V P E S SVT
Sbjct: 29518 EAENQSGKKSATVLVKVYDTPGPCPSVKVKEVSRDSVT 29555
Score = 45.1 bits (105), Expect = 0.002
Identities = 67/321 (20%), Positives = 117/321 (36%), Gaps = 50/321 (15%)
Query: 2542 SASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVG---------SRLRIPQVTP 2592
S + G T ++ ++W+ R G + S + G ++L IP VT
Sbjct: 14 SVVVLEGSTATFEAHISGFPVPEVSWF-RDGQVISTSTLPGVQISFSDGRAKLTIPAVTK 72
Query: 2593 ADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES-SSPTVVEGQTLDLNC 2651
A+SG Y +NG+G ++ + ++ +PP ++ S TV +G + L
Sbjct: 73 ANSGRYSLKATNGSGQATSTAELLVKA-------ETAPPNFVQRLQSMTVRQGSQVRLQV 125
Query: 2652 VVARQPQAIITWYKRGGSLPSRHQTHGSH------LRLHQMSVADSGEYVCRANNNIDAL 2705
V P ++ +Y+ G + S S L + + DSG Y A N++
Sbjct: 126 RVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRA 185
Query: 2706 EASIVISVSPSAGSPSAP----------GSSMPIRIESS-SSHVAEGETLDLNCVVPGQA 2754
++ + V P+ S RIE +H + V+ G A
Sbjct: 186 TSTAELLVQGEEEVPAKKTKTIVSTAQISESRQTRIEKKIEAHFDARSIATVEMVIDGAA 245
Query: 2755 HAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASG 2814
Q+ HK +P ++R P+ + + S P I S
Sbjct: 246 GQQLP-HKTPPRIPPKPKSRSP------TPPSIAAKAQLARQQSPSP--------IRHSP 290
Query: 2815 SSAVHVPAPGGAPPIRIEPSS 2835
S HV AP +P + P++
Sbjct: 291 SPVRHVRAPTPSPVRSVSPAA 311
Score = 45.1 bits (105), Expect = 0.002
Identities = 25/85 (29%), Positives = 38/85 (44%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+ P P E ++A G+ T C G P I+W + S P + + +
Sbjct: 7017 LEPPYFIEPLEHVEAVIGEPATLQCKVDGTPEIRISWYKEHTKLRSAPAYKMQFKNNVAS 7076
Query: 464 LIIRDVKESDQGAYTCEAMNARGMV 488
L+I V SD G Y+C+A N+ G V
Sbjct: 7077 LVINKVDHSDVGEYSCKADNSVGAV 7101
Score = 45.1 bits (105), Expect = 0.002
Identities = 48/201 (23%), Positives = 73/201 (36%), Gaps = 20/201 (9%)
Query: 1676 PLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS---ELH 1732
P V + H V +G L C V GS P W + PS S L
Sbjct: 8345 PPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLE 8404
Query: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPS-KPIT---------VTVEEQRSQS 1782
V +D+G Y+C N+ S+T+++++ + + P+ P T V E +S
Sbjct: 8405 LRDVAKADSGDYVCKASNVAGSDTTKSKVTIKDKPAVAPATKKAAVDGRLFFVSEPQSIR 8464
Query: 1783 VRPGADVTFICTAKSKSPAYTLVWTR------LHNGKLPTRAMDFNGILTIRNVQLSDAG 1836
V TFI P + WT+ G++ L IR+ +D+G
Sbjct: 8465 VVEKTTATFIAKV-GGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKTDSG 8523
Query: 1837 TYVCTGSNMFAMDQGTATLHV 1857
Y C N + L V
Sbjct: 8524 LYRCVAFNEHGEIESNVNLQV 8544
Score = 45.1 bits (105), Expect = 0.002
Identities = 34/131 (25%), Positives = 59/131 (45%), Gaps = 13/131 (9%)
Query: 3553 YRCTATNAAGTTQSHVLLLVQAL-----PQISMPQEVR----VPAGSAAVFPCIASGYPT 3603
+R +A N AG + V+ V+ + P + E+R V AG + G P
Sbjct: 20746 FRISAINDAGVGEPAVIPDVEIVEREMAPDFELDAELRRTLVVRAGLSIRIFVPIKGRPA 20805
Query: 3604 PDISWSKLDGSLPPDSRLEN----NMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVP 3659
P+++W+K + +L + +EN +L++P D G +V T N GK F +++V
Sbjct: 20806 PEVTWTKDNINLKNRANIENTESFTLLIIPECNRYDTGKFVMTIENPAGKKSGFVNVRVL 20865
Query: 3660 ERVVPYFTQTP 3670
+ P P
Sbjct: 20866 DTPGPVLNLRP 20876
Score = 44.7 bits (104), Expect = 0.002
Identities = 53/222 (23%), Positives = 90/222 (40%), Gaps = 17/222 (7%)
Query: 3020 RSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN------VHISPNG 3073
++P + S V +G A+F+ I P + W Q + + + S
Sbjct: 4 QAPTFTQPLQSVVVLEGSTATFEAHISGFPVP-EVSWFRDGQVISTSTLPGVQISFSDGR 62
Query: 3074 SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP--PTVSVLPEGPVWVKVGKAVT 3131
+ +TI +N G Y A+N G A S L V P V + V+ G V
Sbjct: 63 AKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVR 122
Query: 3132 LECVSAGEPRSSARWTRISST-PAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNA 3190
L+ G P ++ R + + L+ + D +++L I+ A P D+GTY A N+
Sbjct: 123 LQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLL-IAEAYPEDSGTYSVNATNS 181
Query: 3191 LGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLR 3232
+G A E++V G +V A++ + V + R
Sbjct: 182 VGRATSTAELLVQ------GEEEVPAKKTKTIVSTAQISESR 217
Score = 44.7 bits (104), Expect = 0.002
Identities = 64/274 (23%), Positives = 90/274 (32%), Gaps = 62/274 (22%)
Query: 2026 VATSPAGTAQARIQVVVLSASDAS-------PPPVKIESSSPS---------VTEGQTLD 2069
V S GT + VL +A P PV+I + P+ V EG+++
Sbjct: 902 VGVSITGTTVREERFEVLHGREAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVT 961
Query: 2070 LNCVVAGSAHAQVTWYRRGGSLPPHT------QVHGSRLRLPQVSPADSGEYVCRVENGS 2123
L C ++G VTWYR + Q +RL + + DSG + C N +
Sbjct: 962 LECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEA 1021
Query: 2124 GPKEASITVSVLHGTHSGPSYTPV------------------------------PGS-TR 2152
G S ++V T V PG
Sbjct: 1022 GTVSTSCYLAVQVSEEFEKETTAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAA 1081
Query: 2153 PIRI-EPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH--------QTHGSLL 2203
P I +P + EG ++ C V G V W K G L + QT L
Sbjct: 1082 PYFITKPVVQKLVEGGSVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKL 1141
Query: 2204 RLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEA 2237
+ D+GEY V G AS + EA
Sbjct: 1142 VISMTFADDAGEYTIVVRNKHGETSASASLLEEA 1175
Score = 44.7 bits (104), Expect = 0.002
Identities = 183/936 (19%), Positives = 311/936 (33%), Gaps = 148/936 (15%)
Query: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPP--QLTVQPGQL 1882
LT+R+V+L DAG T + A+ + P V P TV+ G
Sbjct: 12252 LTLRDVKLEDAGEVQLTAKD----------FKTHANLFVKEPPVEFTKPLEDQTVEEGAT 12301
Query: 1883 AEFRCSATGSPTPTLEWTGGPGGQLPAKAQI--HGGILRLPAVE--PTDQAQYLCRAHSS 1938
A C + + G K +I G + +L + P D Y C A
Sbjct: 12302 AVLECEVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKLVIHDCTPEDIKTYTCDAKDF 12361
Query: 1939 AGQQVARAVLHVHGGGGPRVQVSPERT--QVHAGRTVRLYCRAAGVPSATITWRKEGGSL 1996
V P V+ T QV R C + +A + W K+G +
Sbjct: 12362 KTSCNLNVV-------PPHVEFLRPLTDLQVREKEMARFECELSR-ENAKVKWFKDGAEI 12413
Query: 1997 PPQARSE---RTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPV 2053
+ + + + L+I D Y C TA+ + VL +
Sbjct: 12414 KKGKKYDIISKGAVRILVINKCLLDDEAEYSC----EVRTARTSGMLTVLEEEAVFTKNL 12469
Query: 2054 KIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYR------RGGSLPPHTQVHGSRLRLPQV 2107
++ V+E T+ L C V+ A+V WY+ G T+ L +
Sbjct: 12470 ----ANIEVSETDTIKLVCEVS-KPGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNA 12524
Query: 2108 SPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQ 2167
D+G Y CR+ S + + V L +P + + EG+
Sbjct: 12525 HLEDAGNYNCRLP--SSRTDGKVKVHELAAEFIS---------------KPQNLEILEGE 12567
Query: 2168 TLDLNCVVPGQAHAQVTWHKRGGSLPARHQ------THGSLLRLHQVTPADSGEYVCHVV 2221
+ C + ++ V W + +L + + +L + T D G Y VV
Sbjct: 12568 KAEFVCSISKESF-PVQWKRDDKTLESGDKYDVIADGKKRVLVVKDATLQDMGTY---VV 12623
Query: 2222 GTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKR 2281
A+ L IE I P+ R++ E Q + +C V + A+ W++
Sbjct: 12624 MVGAARAAAHLTVIEKLRIVVPLKDTRVK-------EQQEVVFNCEVNTEG-AKAKWFRN 12675
Query: 2282 GGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAG--- 2338
+ S YI + A +A+ V++T +G N+ A
Sbjct: 12676 ------EEAIFDSSKYIILQKDLVYTLRIRDAHLDDQANYNVSLTNHRGENVKSAANLIV 12729
Query: 2339 STQPIRI-EP-SSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQ 2396
+ +RI EP + E +++ C V + + + W K G +P ++
Sbjct: 12730 EEEDLRIVEPLKDIETMEKKSVTFWCKV-NRLNVTLKWTKNGEEVPFDNRV--------- 12779
Query: 2397 ASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGV--TPTVRIESSSSQ-VAEGQT 2453
+ D +++ + P E +VT SV L + PT +E Q V E
Sbjct: 12780 SYRVDKYKHMLTIKDCGFPDEGEYIVTAGQDKSVAELLIIEAPTEFVEHLEDQTVTEFDD 12839
Query: 2454 LDLNCLVAGQAHAQVTWHKRGGSLPA----RHQVHGS--RLRLLQVTPADSGEYVCRVVG 2507
+C ++ + A V W++ G + + + GS RL + D EY C V
Sbjct: 12840 AVFSCQLS-REKANVKWYRNGREIKEGKKYKFEKDGSIHRLIIKDCRLDDECEYACGV-- 12896
Query: 2508 SSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITW 2567
+ R S + PV I + D+ L
Sbjct: 12897 -------------EDRKSRARLFVEEIPVEIIRPPQDILEAPGADVVFLAELNKDKVEVQ 12943
Query: 2568 YKRGGSL---PSRHQIVGS----RLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGS 2620
+ R + +HQ++ RL+I + P D GEY + + L
Sbjct: 12944 WLRNNMVVVQGDKHQMMSEGKIHRLQICDIKPRDQGEYRFIAKDKEARAKLEL------- 12996
Query: 2621 GSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSR---HQTH 2677
+ +P I+ V G+ L + P+A W+K L ++
Sbjct: 12997 ------AAAPKIKTADQDLVVDVGKPLTMVVPYDAYPKAEAEWFKENEPLSTKTIDTTAE 13050
Query: 2678 GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISV 2713
+ R+ + D G Y N E I + V
Sbjct: 13051 QTSFRILEAKKGDKGRYKIVLQNKHGKAEGFINLKV 13086
Score = 44.7 bits (104), Expect = 0.002
Identities = 85/413 (20%), Positives = 151/413 (36%), Gaps = 60/413 (14%)
Query: 3146 WTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTG 3205
W+R + K+ Q T + A ++ + + AG + A+ Q V+
Sbjct: 15048 WSRCTEKMIKVRQYTVKEIREGADYKLRVSAVNAAGEGPPGETQPVTVAEPQEPPAVELD 15107
Query: 3206 AMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDT--- 3262
G Q+ A G T + TG P PT W+K L + R+ D
Sbjct: 15108 VSVKGGIQIMA---------GKTLRIPAVVTGRPVPTKVWTKEEGELD-KDRVVIDNVGT 15157
Query: 3263 ---LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQ 3319
LII ++D G+Y+ AT+ G A + V P G + L+
Sbjct: 15158 KSELIIKDALRKDHGRYVITATNSCGSKFAAARVEVFDVP-------------GPVLDLK 15204
Query: 3320 CLAHGTPPLTFQWSRV----GSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAE 3375
+ WS GS + G R + P ++ R +C +T + E
Sbjct: 15205 PVVTNRKMCLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQPIETERSKCDITGLLEGQE 15264
Query: 3376 AFAQLLVQ-----GPPGSL-PATSIPAGSTPTV--QVTPQLETKSIGASVEFHCAVP-SD 3426
+++ + GPP + P ++ PT ++T TKS ++ P S+
Sbjct: 15265 YKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTSPERLTYTERTKS---TITLDWKEPRSN 15321
Query: 3427 RGTQLRWF---KEGGQLPPGHSVQDGV-----LRIQNLDQSCQGTYICQAHGPWGKAQAS 3478
G+ ++ + K P V + ++NLD+ + +A G+++ S
Sbjct: 15322 GGSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVENLDEHQMYEFRVKAVNEIGESEPS 15381
Query: 3479 AQLVI-----QALPSVLINIRTSVQTVVV--GHAVEFECLALGDPKPQVTWSK 3524
L + + P++ + + T+ V G V G P P++ WSK
Sbjct: 15382 LPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHIPADVTGLPMPKIEWSK 15434
Score = 44.7 bits (104), Expect = 0.002
Identities = 95/412 (23%), Positives = 146/412 (35%), Gaps = 86/412 (20%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDI------ATLLIPAITTADA 2020
V G+T+R+ R G P ITW KEG L R +R D+ L I AD
Sbjct: 17920 VRVGQTIRILARVKGRPEPDITWTKEGKVL---VREKRVDLIQDLPRVELQIKEAVRADH 17976
Query: 2021 GFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDL-NCVVAGSAH 2079
G Y+ A + +G AQ V VL P P + + E T+ N + G +
Sbjct: 17977 GKYIISAKNSSGHAQGSAIVNVLD----RPGPCQNLKVTNVTKENCTISWENPLDNGGSE 18032
Query: 2080 AQ--VTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRV--EN--GSGPKEASITVS 2133
+ YR+ RL + + + EY RV EN G GP + T
Sbjct: 18033 ITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVCAENKVGVGPTIETKTPI 18092
Query: 2134 VLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK---RGG 2190
+ P EP + H+A+ G+ + W + GG
Sbjct: 18093 LAINPIDRPG-------------EPENLHIAD----------KGKTFVYLKWRRPDYDGG 18129
Query: 2191 SLPARHQTH--------------GSLLRLHQVTP--ADSGEYVCHVVGTSGPLEASVLVT 2234
S + GS+ H + ++ Y V + E+ + T
Sbjct: 18130 SPNLSYHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKT 18189
Query: 2235 IEASV---IPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK--------RGG 2283
E V + P+ +++ S TV G T+ L V G+ +V W K R
Sbjct: 18190 EEVVVKEDLQKPVLDLKL-SGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSP 18248
Query: 2284 SLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAY 2335
+ + S+ + +A +D G+YV VT T T G+ +AY
Sbjct: 18249 RVKIDTRADSSKFSLTKAKRSDGGKYV------------VTATNTAGSFVAY 18288
Score = 44.7 bits (104), Expect = 0.002
Identities = 80/423 (18%), Positives = 155/423 (36%), Gaps = 53/423 (12%)
Query: 2565 ITWYKRGGSLPSRHQIVG----SRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGS 2620
ITW + G + QI ++L I D+G+Y+ + N +GS+ + V + +
Sbjct: 24056 ITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYILKLENSSGSKSAFVTVKVLDT 24115
Query: 2621 GSSHVPSVSPPIRIESS----SPTVVEGQTLDLNCVV-----ARQPQAIITWYKRGGSLP 2671
+R +S+ P +++G N V+ R+ A ++ S
Sbjct: 24116 PGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVIDKRESTRKAYANVSSKCSKTSFK 24175
Query: 2672 SRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRI 2731
+ T G+ M+ + G V +DA++A A PS PG +
Sbjct: 24176 VENLTEGAIYYFRVMAENEFGVGV--PVETVDAVKA---------AEPPSPPGKVTLTDV 24224
Query: 2732 ESSSSHVA------EGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSP 2785
+S+ + +G + L VV Q W S + G +S
Sbjct: 24225 SQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVAESKVCNAVVTG-------LSS 24277
Query: 2786 ADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLD 2845
++ + G + VL + + P +++ ++ + G+ L
Sbjct: 24278 GQEYQFRVKAYNEKGKSDPRVLGVPVIAKDLTIQ-------PSLKLPFNTYSIQAGEDLK 24330
Query: 2846 LKCVVPGQAHAQVTWHKRGGNLPARHQVH------GPLLRLNQVSPADSGEYSCQVTGSS 2899
++ V G+ ++W K G L +V+ +L + + + D G+Y+ T S+
Sbjct: 24331 IEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGKYTVTATNSA 24390
Query: 2900 GTL--EASVLVTIEPSSP-GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQV 2956
GT SV+V +P P GP+ ++ + + G N +V +
Sbjct: 24391 GTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPAYTGGCQISNYIVEKRDTTTT 24450
Query: 2957 TWY 2959
TW+
Sbjct: 24451 TWH 24453
Score = 44.7 bits (104), Expect = 0.002
Identities = 119/559 (21%), Positives = 196/559 (35%), Gaps = 74/559 (13%)
Query: 1865 APVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW-------TGGPGGQLPAKAQIHGGI 1917
AP + +T + G+ A+ C G P P ++W ++ + + H
Sbjct: 30532 APGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTH--T 30589
Query: 1918 LRLPAVEPTDQAQYLCRAHSSAGQ------QVARAVLHVHGGGGPRVQVSPERTQVHAGR 1971
L + E D+ Y C A + G+ + +A H G E+ G
Sbjct: 30590 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPG-----YPLKEKYYGAVGS 30644
Query: 1972 TVRLYCRAAGVPSATITWRKEGGSLPPQARS---ERTDIATLLI--PAITTADAGFYLCV 2026
T+RL+ G P +TW G L + + E T+ T L+ AG Y
Sbjct: 30645 TLRLHVMYIGRPVPAMTW-FHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQ 30703
Query: 2027 ATSPAGTAQARIQVVVLSASDASPPPVKIE---------SSSPSVTEGQTLDLNCVVAG- 2076
++ GT A + V + D P+ IE S P +G + N VV
Sbjct: 30704 LSNVFGTVDAILDVEIQDKPDKPTGPIVIEALLKNSAVISWKPPADDGGSWITNYVVEKC 30763
Query: 2077 SAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVE-----NGSGPKEASIT 2131
A W ++ V R+ V+ ++ Y RV S P E S
Sbjct: 30764 EAKEGAEWQLVSSAI----SVTTCRI----VNLTENAGYYFRVSAQNTFGISDPLEVSSV 30815
Query: 2132 VSVLH-----GTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWH 2186
V + G P+ T V + + +P +S +G N + + Q W
Sbjct: 30816 VIIKSPFEKPGAPGKPTITAVTKDSCVVAWKPPAS---DGGAKIRNYYLEKREKKQNKW- 30871
Query: 2187 KRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPP 2246
+ +T S+ L + + ++ G S E S +T ++ V P P
Sbjct: 30872 -ISVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDV-PIQAPH 30929
Query: 2247 VRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR------HQVRGS--RLYI 2298
+ E + V L C V G V WY++G + A + +G +L I
Sbjct: 30930 FKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLII 30989
Query: 2299 FQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSS-QVAEGQT 2357
+ DA Y RA+N +V+GT + PA P +E + G+
Sbjct: 30990 ASVTDDDATVYQVRATNQ-----GGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEV 31044
Query: 2358 LDLNCVVPGQSHAQVTWHK 2376
+ + G+ +TW K
Sbjct: 31045 VSIKIPFSGKPDPVITWQK 31063
Score = 44.3 bits (103), Expect = 0.003
Identities = 100/443 (22%), Positives = 154/443 (34%), Gaps = 88/443 (19%)
Query: 1672 TNQAPLVVEVHPARSIVP-QGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS- 1729
T QAP + P +S+V +G + + +SG P W R DG+ + + T Q S
Sbjct: 2 TTQAPTFTQ--PLQSVVVLEGSTATFEAHISGFPVPEVSWFR-DGQVISTSTLPGVQISF 58
Query: 1730 -----ELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVR 1784
+L P+V +++G Y N TS AELLV + P V+ +S +VR
Sbjct: 59 SDGRAKLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPP--NFVQRLQSMTVR 116
Query: 1785 PGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN-------GILTIRNVQLSDAGT 1837
G+ V + + P + + R +G ++DF L I D+GT
Sbjct: 117 QGSQVR-LQVRVTGIPTPVVKFYR--DGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGT 173
Query: 1838 YVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFR----------- 1886
Y +N TA L VQ + A + V Q++E R
Sbjct: 174 YSVNATNSVGRATSTAELLVQGEEEVPA-----KKTKTIVSTAQISESRQTRIEKKIEAH 228
Query: 1887 CSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARA 1946
A T + G G QLP K P + P +++ +A Q+AR
Sbjct: 229 FDARSIATVEMVIDGAAGQQLPHKTP--------PRIPPKPKSRSPTPPSIAAKAQLAR- 279
Query: 1947 VLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD 2006
+ SP R R VR A PS S+ P AR +
Sbjct: 280 ----------QQSPSPIRHSPSPVRHVR-----APTPSPV-------RSVSPAARISTSP 317
Query: 2007 IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQ 2066
I ++ P + + Q ++ PPP K E S +E +
Sbjct: 318 IRSVRSPLL-------------------MRKTQASTVATGPEVPPPWKQEGYVASSSEAE 358
Query: 2067 TLDLNCVVAGSAHAQVTWYRRGG 2089
+ + + W R G
Sbjct: 359 MRETTLTTSTQIRTEERWEGRYG 381
Score = 44.3 bits (103), Expect = 0.003
Identities = 24/76 (31%), Positives = 34/76 (44%), Gaps = 1/76 (1%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINW-RLNWGHIPSHPRVTVTSEGGRGTLIIRDVKES 472
+SI+ T TF G P P + W + W + RV + +G L IRD ++
Sbjct: 8461 QSIRVVEKTTATFIAKVGGDPIPNVKWTKGKWRQLNQGGRVFIHQKGDEAKLEIRDTTKT 8520
Query: 473 DQGAYTCEAMNARGMV 488
D G Y C A N G +
Sbjct: 8521 DSGLYRCVAFNEHGEI 8536
Score = 44.3 bits (103), Expect = 0.003
Identities = 37/154 (24%), Positives = 67/154 (43%), Gaps = 20/154 (12%)
Query: 1956 PRVQVSPERTQ---VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQ---ARSERTDIAT 2009
PR+ +S V AG V L G P T++W+K+G L P + + ++ T
Sbjct: 19293 PRIDLSVAMKSLLTVKAGTNVCLDATVFGKPMPTVSWKKDGTLLKPAEGIKMAMQRNLCT 19352
Query: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIE-----------SS 2058
L + ++ D+G Y A + +G+ A I++ VL D PP ++ S
Sbjct: 19353 LELFSVNRKDSGDYTITAENSSGSKSATIKLKVL---DKPGPPASVKINKMYSDRAMLSW 19409
Query: 2059 SPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLP 2092
P + +G + N +V ++ W + ++P
Sbjct: 19410 EPPLEDGGSEITNYIVDKRETSRPNWAQVSATVP 19443
Score = 43.9 bits (102), Expect = 0.004
Identities = 33/128 (25%), Positives = 54/128 (42%), Gaps = 16/128 (12%)
Query: 3553 YRCTATNAAGT------TQSHVLLLVQALPQISMPQEV----RVPAGSAAVFPCIASGYP 3602
YR A N G T+ + Q P+I + ++ V AG+ P +G P
Sbjct: 13659 YRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKP 13718
Query: 3603 TPDISWSKLDGSLPPDSRL------ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHL 3656
P I+W+K D L D R+ + + + + + D GTY+ A N G+ A +
Sbjct: 13719 EPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEAVNVCGRATAVVEV 13778
Query: 3657 QVPERVVP 3664
V ++ P
Sbjct: 13779 NVLDKPGP 13786
Score = 43.9 bits (102), Expect = 0.004
Identities = 35/121 (28%), Positives = 50/121 (41%), Gaps = 14/121 (11%)
Query: 3295 VESPPYATTVPEHASV--QAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHF 3352
VE+P V +V +AGE +L+ G PP T +WS+ G L G A ++ F
Sbjct: 21456 VEAPKIKVDVKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADF 21515
Query: 3353 ------ERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTP 3406
+ + DSG Y TN G A+ + V PG P G +VT
Sbjct: 21516 STNLVNKDSTRRDSGAYTLTATNPGGFAKHIFNVKVLDRPGP------PEGPLAVTEVTS 21569
Query: 3407 Q 3407
+
Sbjct: 21570 E 21570
Score = 43.9 bits (102), Expect = 0.004
Identities = 39/144 (27%), Positives = 59/144 (40%), Gaps = 15/144 (10%)
Query: 1956 PRVQVSPERTQ---VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE--RTDIAT- 2009
PR+ + P+ VHAG + ++ G P TI W K L AR E TD AT
Sbjct: 22541 PRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFATS 22600
Query: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSS---------P 2060
L + D+G Y+ A + AG + V VL PV I + P
Sbjct: 22601 LSVKDAVRVDSGNYILKAKNVAGERSVTVNVKVLDRPGPPEGPVVISGVTAEKCTLAWKP 22660
Query: 2061 SVTEGQTLDLNCVVAGSAHAQVTW 2084
+ +G + +N +V +++ W
Sbjct: 22661 PLQDGGSDIINYIVERRETSRLVW 22684
Score = 43.9 bits (102), Expect = 0.004
Identities = 194/982 (19%), Positives = 329/982 (33%), Gaps = 152/982 (15%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT-LLIPAITTADAGFYLC 2025
V G +RL G P W KEG + +A ++ T L+I D+G Y
Sbjct: 30148 VRQGGVIRLTIPIKGKPFPICKWTKEGQDISKRAMIATSETHTELVIKEADRGDSGTYDL 30207
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKIE---------SSSPSVTEGQTLDLNCVVAG 2076
V + G I+V V+ + ++ P++ + S P +G L ++
Sbjct: 30208 VLENKCGKKAVYIKVRVIGSPNSPEGPLEYDDIQVRSVRVSWRPPADDGGADILGYILER 30267
Query: 2077 SAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRV--ENGSGPKEASITVSV 2134
+ WY ++V G+ L + + ++ EY RV EN G + +
Sbjct: 30268 REVPKAAWYTID------SRVRGTSLVVKGLK--ENVEYHFRVSAENQFGISKPLKSEEP 30319
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVA--------EGQTLDLNCVVPGQAHAQVTWH 2186
+ T P P P S P ++ + S V+ +G + + + + W
Sbjct: 30320 V--TPKTPLNPPEPPSNPPEVLDVTKSSVSLSWSRPKDDGGSRVTGYYIERKETSTDKW- 30376
Query: 2187 KRGGSLPARHQTHGSLLRLHQVTP-ADSGEYVCHV-----VGTSGPLEASVLVT----IE 2236
RH ++ VT EY + VG S AS V +
Sbjct: 30377 -------VRHNKTQITTTMYTVTGLVPDAEYQFRIIAQNDVGLSETSPASEPVVCKDPFD 30429
Query: 2237 ASVIPGPIPPVRIESSSSTV------AEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQ 2290
PG + + I S T+ +G L V + W K + +
Sbjct: 30430 KPSQPGELEILSISKDSVTLQWEKPECDGGKEILGYWVEYRQSGDSAWKKSN-----KER 30484
Query: 2291 VRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSS 2350
++ + I +A +Y R E ++ +G IR E
Sbjct: 30485 IKDKQFTI--GGLLEATEYEFRVFAENETGLSRPRRTAMSIKTKLTSGEAPGIRKEMKDV 30542
Query: 2351 QVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGS------LLRLYQASPADSGE 2404
G+ L+C + G+ + W++ G L + S L + D G
Sbjct: 30543 TTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQEDEGV 30602
Query: 2405 YVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQV---AEGQTLDLNCLVA 2461
Y C +E S + ++ TP + A G TL L+ +
Sbjct: 30603 YTCIATNEVGEVETSSKLLLQ---------ATPQFHPGYPLKEKYYGAVGSTLRLHVMYI 30653
Query: 2462 GQAHAQVTWH------KRGGSLPARHQVHGSRLRLLQVT-PADSGEYVCRVVGSSGTQEA 2514
G+ +TW + ++ + H + L + V +G+Y ++ GT +A
Sbjct: 30654 GRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNVFGTVDA 30713
Query: 2515 SVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWY---KRG 2571
+ V IQ + P+ IE A L N + A IT Y K
Sbjct: 30714 ILDVEIQDKPDKPTG-----PIVIE---ALLKNSAVISWKP-PADDGGSWITNYVVEKCE 30764
Query: 2572 GSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGS-GSSHVPSVSP 2630
+ Q+V S + + C + N + V+ Q + G S VS
Sbjct: 30765 AKEGAEWQLVSSAISVT----------TCRIVNLTENAGYYFRVSAQNTFGISDPLEVSS 30814
Query: 2631 PIRIES--------SSPTVVEGQTLDLNCVVARQPQAIITWYK-RGGSLPSRHQTHGSHL 2681
+ I+S PT+ T D +CVVA +P A K R L R + +
Sbjct: 30815 VVIIKSPFEKPGAPGKPTIT-AVTKD-SCVVAWKPPASDGGAKIRNYYLEKREKKQNKWI 30872
Query: 2682 RLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGS--------PSAPGSSMPIRI-- 2731
++ + E V N I+ LE + G P P S +PI+
Sbjct: 30873 ---SVTTEEIRETVFSVKNLIEGLEYEFRVKCENLGGESEWSEISEPITPKSDVPIQAPH 30929
Query: 2732 ---ESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSH------HQTRGS--RLRL 2780
E + +V L C V G V W+++G + + + +G +L +
Sbjct: 30930 FKEELRNLNVRYQSNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLII 30989
Query: 2781 HHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE 2840
V+ D+ Y R G ++ + S V VPA P +
Sbjct: 30990 ASVTDDDATVYQVRATNQGG--------SVSGTASLEVEVPAKIHLPKTLEGMGAVHALR 31041
Query: 2841 GQTLDLKCVVPGQAHAQVTWHK 2862
G+ + +K G+ +TW K
Sbjct: 31042 GEVVSIKIPFSGKPDPVITWQK 31063
Score = 43.9 bits (102), Expect = 0.004
Identities = 24/91 (26%), Positives = 40/91 (43%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
+ + G+ +C +G P P I W + + ++S+G TL + ++ D
Sbjct: 30540 KDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHTLTVMTEEQED 30599
Query: 474 QGAYTCEAMNARGMVFGIPDGVLELVPQRGP 504
+G YTC A N G V +L+ PQ P
Sbjct: 30600 EGVYTCIATNEVGEVETSSKLLLQATPQFHP 30630
Score = 43.9 bits (102), Expect = 0.004
Identities = 50/177 (28%), Positives = 71/177 (40%), Gaps = 18/177 (10%)
Query: 1695 SLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQG-----SELHFPSVQPSDAGVYICTCR 1749
+L C+V+G P W R+ + G + R Q +L SV DA VY
Sbjct: 30946 TLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQVRAT 31005
Query: 1750 NLHQSNTSRAELLVTEAPSK-PITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR 1808
N S + A L V E P+K + T+E + G +V I S P + W +
Sbjct: 31006 NQGGSVSGTASLEV-EVPAKIHLPKTLEGMGAVHALRG-EVVSIKIPFSGKPDPVITWQK 31063
Query: 1809 L--------HNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV 1857
H + TR+ F ++ V+ DAG YV N F +DQ T L V
Sbjct: 31064 GQDLIDNNGHYQVIVTRS--FTSLVFPNGVERKDAGFYVVCAKNRFGIDQKTVELDV 31118
Score = 43.5 bits (101), Expect = 0.005
Identities = 32/133 (24%), Positives = 54/133 (40%), Gaps = 9/133 (6%)
Query: 3532 GIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSA 3591
G+ +G VR E+ + + T T + V + V +S + V V G +
Sbjct: 903 GVSITGTTVREERFEVLHGREAKVTET---ARVPAPVEIPVTPPTLVSGLKNVTVIEGES 959
Query: 3592 AVFPCIASGYPTPDISWSKLDGSLPPDSRLENNM------LMLPSVRPQDAGTYVCTATN 3645
C SGYP+P ++W + D + + LM+ +D+G + C+A N
Sbjct: 960 VTLECHISGYPSPTVTWYREDYQIESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVN 1019
Query: 3646 RQGKVKAFAHLQV 3658
G V +L V
Sbjct: 1020 EAGTVSTSCYLAV 1032
Score = 43.5 bits (101), Expect = 0.005
Identities = 106/505 (20%), Positives = 175/505 (34%), Gaps = 69/505 (13%)
Query: 3200 VIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRL- 3258
VI+ + P A +T +AG T+ +G PAP + W L R+
Sbjct: 28636 VIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVS 28695
Query: 3259 -----EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP-EHASVQA 3312
+ TL + + DSG+Y + AG ++ + V P T P E +SV A
Sbjct: 28696 ITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVVIGRPGPVTGPIEVSSVSA 28755
Query: 3313 -------------GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPED 3359
G T + T W V SS+ L + +
Sbjct: 28756 ESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYSFRV 28815
Query: 3360 SGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEF 3419
S R V+ + SA A+ PP + + S + + + G+ +
Sbjct: 28816 SSENRFGVSKPLESAPIIAEHPFV-PPSAPTRPEVYHVSANAMSIRWEEPYHDGGSKIIG 28874
Query: 3420 HCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASA 3479
+ +R T L W KE ++P ++ L+ + TY A G ++AS
Sbjct: 28875 YWVEKKERNTIL-WVKEN-KVPCLECNYKVTGLVEGLEYQFR-TYALNAAGVSKASEASR 28931
Query: 3480 QLVIQ------ALPSVLINIRTSVQTV-----------VVGHAVEFECLA-LGDPKPQVT 3521
++ Q P V R++V + VVG+ +E + ++ +GD +
Sbjct: 28932 PIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIERKPVSEVGDGR---- 28987
Query: 3522 WSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQ--SHVLLLVQALPQIS 3579
W K + S + + D ++R A NAAG S V + +
Sbjct: 28988 WLKCNY-----TIVSDNFFTVTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYA 29042
Query: 3580 MPQE----------VRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL------EN 3623
P+ V + AGS V G P P I W+K D L ++ +
Sbjct: 29043 PPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKR 29102
Query: 3624 NMLMLPSVRPQDAGTYVCTATNRQG 3648
++ D+G Y T N G
Sbjct: 29103 ATAVIKFCDRSDSGKYTLTVKNASG 29127
Score = 43.5 bits (101), Expect = 0.005
Identities = 60/250 (24%), Positives = 93/250 (37%), Gaps = 26/250 (10%)
Query: 1863 LSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKA------QIHGG 1916
+ AP L V+ A C TG P P ++W G ++ A + GG
Sbjct: 30925 IQAPHFKEELRNLNVRYQSNATLVCKVTGHPKPIVKWY-RQGKEIIADGLKYRIQEFKGG 30983
Query: 1917 I--LRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPE-RTQVHA--GR 1971
L + +V D Y RA + G A L V + + E VHA G
Sbjct: 30984 YHQLIIASVTDDDATVYQVRATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGE 31043
Query: 1972 TVRLYCRAAGVPSATITWRKEGGSLPPQARSE---RTDIATLLIP-AITTADAGFYLCVA 2027
V + +G P ITW+K + + +L+ P + DAGFY+ A
Sbjct: 31044 VVSIKIPFSGKPDPVITWQKGQDLIDNNGHYQVIVTRSFTSLVFPNGVERKDAGFYVVCA 31103
Query: 2028 TSPAGTAQARIQVVV---------LSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSA 2078
+ G Q +++ V + SD S V + + P+ ++G + N +V A
Sbjct: 31104 KNRFGIDQKTVELDVADVPDPPRGVKVSDVSRDSVNLTWTEPA-SDGGSKITNYIVEKCA 31162
Query: 2079 HAQVTWYRRG 2088
W R G
Sbjct: 31163 TTAERWLRVG 31172
Score = 43.1 bits (100), Expect = 0.006
Identities = 50/233 (21%), Positives = 83/233 (35%), Gaps = 28/233 (12%)
Query: 2043 LSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWY---RRGGS-----LPPH 2094
+ D SPP + + P ++ + +TW GGS + +
Sbjct: 17092 IGIGDPSPPSKPVFAKDPIAKPSPPVNPEAIDTTCNSVDLTWQPPRHDGGSKILGYIVEY 17151
Query: 2095 TQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGT-HSGPSYTPVPGSTRP 2153
+V R +P E +V + V ++ S P++ P P +
Sbjct: 17152 QKVGDEEWRRANHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKD 17211
Query: 2154 IRIEPSS----------SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH---- 2199
R+EP H+ G TL L+ ++ G +VTW K P + +
Sbjct: 17212 -RLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPV 17270
Query: 2200 GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESS 2252
GS L + D G Y V +G S V+++ V+ P PP +E S
Sbjct: 17271 GSKLEIRNAAHEDGGIYSLTVENPAG----SKTVSVKVLVLDKPGPPRDLEVS 17319
Score = 43.1 bits (100), Expect = 0.006
Identities = 254/1272 (19%), Positives = 447/1272 (35%), Gaps = 210/1272 (16%)
Query: 2166 GQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH------GSLLRLHQVTPADSGEYVCH 2219
G + + V G+ VTW K L + + ++L +++ +DSG Y
Sbjct: 21080 GDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTATSTILNINECVRSDSGPYPLT 21139
Query: 2220 VVGTSGPLEASVLVTIEASVIPGP-IPPVRIESSSSTVA---------EGQTLDLSCVVA 2269
G E ++TI+ IPGP P++ + SS +G + VV
Sbjct: 21140 ARNIVG--EVGDVITIQVHDIPGPPTGPIKFDEVSSDFVTFSWDPPENDGGVPISNYVVE 21197
Query: 2270 GQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEASIT-VTVT 2326
+ TW + ++ R + +RL + Q+ +A N G+ IT +
Sbjct: 21198 MRQTDSTTWVELATTV-IRTTYKATRL-----TTGLEYQFRVKAQNRYGVGPGITSACIV 21251
Query: 2327 GTQGANLAYPAGSTQPIRIEPSSSQVA------EGQTLDLNCVVPGQSHAQVTWHKRGGS 2380
+ P G+ Q + S ++ +G + L V + + W +
Sbjct: 21252 ANYPFKVPGPPGTPQVTAVTKDSMTISWHEPLSDGGSPILGYHVERKERNGILWQTVSKA 21311
Query: 2381 LPVRHQTHGSLLRLYQASPADSGEYVCRVL-----GSSVPLEAS----VLVTIEPAGSVP 2431
L G++ + + D Y RV+ G S P + S L I+P G
Sbjct: 21312 L-----VPGNIFK--SSGLTDGIAYEFRVIAENMAGKSKPSKPSEPMLALDPIDPPGKPV 21364
Query: 2432 ALGVTP-TVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRL 2490
L +T TV ++ + + G + + +V + W K S ++ S L
Sbjct: 21365 PLNITRHTVTLKWAKPEYTGGFKIT-SYIVEKRDLPNGRWLKANFSNILENEFTVSGL-- 21421
Query: 2491 LQVTPADSGEYVCRVVGSSGT------QEASVLVTIQQRLSGSHSQGVAYPVRIESSSAS 2544
+ Y RV+ + E S +T + + + V+ + +
Sbjct: 21422 -----TEDAAYEFRVIAKNAAGAISPPSEPSDAITCRDDVEAPK---IKVDVKFKDT-VI 21472
Query: 2545 LANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI------VGSRLRIPQVTPADSGEY 2598
L G L V+ + P T+ W K G L ++ + L T DSG Y
Sbjct: 21473 LKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAY 21532
Query: 2599 VCHVSNGAGSRETSLIVTIQG-----SGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVV 2653
+N G + V + G V V+ + S P + +G + +V
Sbjct: 21533 TLTATNPGGFAKHIFNVKVLDRPGPPEGPLAVTEVTSEKCVLSWFPPLDDGGAKIDHYIV 21592
Query: 2654 ARQPQAIITWYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCR--ANNNI---DALEAS 2708
++ + + W ++ S Q +L + EY+ R A N + LE+
Sbjct: 21593 QKRETSRLAWT----NVASEVQV----TKLKVTKLLKGNEYIFRVMAVNKYGVGEPLESE 21644
Query: 2709 IVISVSPSAGSPSAPGSSMPIRIESSSSHV------AEGETLDLNCVVPGQAHAQVTWHK 2762
V++V+P G P P + I S V ++G + +N +V + A W K
Sbjct: 21645 PVLAVNPY-GPPDPPKNPEVTTITKDSMVVCWGHPDSDGGSEIINYIVERRDKAGQRWIK 21703
Query: 2763 RGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVM-----GSSGPLEASVLVTIEASGSSA 2817
+ + + S L H EY R+M G S P S
Sbjct: 21704 CNKKTLTDLRYKVSGLTEGH-------EYEFRIMAENAAGISAPSPTSPFY----KACDT 21752
Query: 2818 VHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKR---GGNLPARHQVH 2874
V P P G P + ++ S S ++ + W+K GG+ + V
Sbjct: 21753 VFKPGPPGNPRV-LDTSRSSIS------------------IAWNKPIYDGGSEITGYMVE 21793
Query: 2875 GPLLRLNQ----VSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPA--PG------ 2922
L ++ PA S +TG + E + + S PA PG
Sbjct: 21794 IALPEEDEWQIVTPPAGLKATSYTITGLTENQEYKIRIYAMNSEGLGEPALVPGTPKAED 21853
Query: 2923 --LAQPIYIEASSSHVTEGQ---TLDLNCVVPGQAHAQVTWYK-RGGSLPARHQTHGSQL 2976
L I ++A V + TL L + G+ +V W + G SL S
Sbjct: 21854 RMLPPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSY 21913
Query: 2977 RLHLVSPA---DSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLR-------SPVISI 3026
L +V DSG+Y+ + G + A V V + G L+ S ++
Sbjct: 21914 TLLIVGNVNRFDSGKYILTVENSSG-SKSAFVNVRVLDTPGPPQDLKVKEVTKTSVTLTW 21972
Query: 3027 DPPSSTVQQGQDASFKCLIHDGAAPIS---LEWKTRNQELEDNVHISPNGSIITIVGTRP 3083
DPP + DG + I +E + ++ V + + + + +
Sbjct: 21973 DPP---------------LLDGGSKIKNYIVEKRESTRKAYSTVATNCHKTSWKVDQLQE 22017
Query: 3084 SNHGTYRCVASNAYGV---AQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAG-E 3139
+R +A N YG+ A++ ++ P LP G + + VT VS E
Sbjct: 22018 GCSYYFRVLAENEYGIGLPAETAESVKASERP----LPPGKITLM---DVTRNSVSLSWE 22070
Query: 3140 PRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK-----PSDAGTYVCLAQNALGTA 3194
+RI +++ + + A ++++ A + ++ AQN G +
Sbjct: 22071 KPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGIS 22130
Query: 3195 Q-KQVEV-IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL 3252
+Q+ V ++ + P P + TV AG + G P P + W K PL
Sbjct: 22131 DPRQLSVPVIAKDLVIP--PAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPL 22188
Query: 3253 PWQHRLEGDT------LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE 3306
R+ ++ L I ++D G Y+ T+ AG A T+ + V P T P
Sbjct: 22189 KQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGPV 22248
Query: 3307 HASVQAGETVQL 3318
+++ L
Sbjct: 22249 KMDEVTADSITL 22260
Score = 43.1 bits (100), Expect = 0.006
Identities = 27/85 (31%), Positives = 38/85 (44%), Gaps = 3/85 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHP--RVTVTSEGGR 461
+PP++ P + I G+ +T C G PTP + W I S R + +
Sbjct: 33327 IPPKIEALPSD-ISIDEGKVLTVACAFTGEPTPEVTWSCGGRKIHSQEQGRFHIENTDDL 33385
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
TLII DV++ D G YT N G
Sbjct: 33386 TTLIIMDVQKQDGGLYTLSLGNEFG 33410
Score = 42.7 bits (99), Expect = 0.008
Identities = 36/133 (27%), Positives = 48/133 (36%), Gaps = 11/133 (8%)
Query: 354 TDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPR 413
TD T E + C++TNM +E P E PP V P
Sbjct: 7733 TDNTCALTVNMLEESDSGDYTCIATNMA------GSDECSAPLTVRE----PPSFVQKP- 7781
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
+ + G VTFT + G P ++W + R V+ E L + DV S
Sbjct: 7782 DPMDVLTGTNVTFTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQ 7841
Query: 474 QGAYTCEAMNARG 486
G YTC N G
Sbjct: 7842 SGEYTCIVSNEAG 7854
Score = 42.7 bits (99), Expect = 0.008
Identities = 31/91 (34%), Positives = 43/91 (47%), Gaps = 10/91 (10%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDI----ATLLIPAITTADAGF 2022
V AG +RL+ G P+ +TWRK G + R + D+ A L+IP T D+G
Sbjct: 18618 VRAGCPIRLFAIVRGRPAPKVTWRKVG--IDNVVRKGQVDLVDTMAFLVIPNSTRDDSGK 18675
Query: 2023 YLCVATSPAGTAQARIQVVVLSASDASPPPV 2053
Y +PAG + V VL +P PV
Sbjct: 18676 YSLTLVNPAGEKAVFVNVRVLD----TPGPV 18702
Score = 42.7 bits (99), Expect = 0.008
Identities = 80/416 (19%), Positives = 149/416 (35%), Gaps = 66/416 (15%)
Query: 1875 LTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGI----LRLPAVEPTDQAQ 1930
+ V+ G A G PTP + W+ G+ K QI G+ L + + D +
Sbjct: 24034 IVVRAGGSARIHIPFKGRPTPEITWS-REEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGK 24092
Query: 1931 YLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTV---RLYCRAAGVPSATI 1987
Y+ + +S+G + A + V GP ++ + + + V + A V + I
Sbjct: 24093 YILKLENSSGSKSAFVTVKVLDTPGPPQNLAVKEVRKDSAFLVWEPPIIDGGAKVKNYVI 24152
Query: 1988 TWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASD 2047
++E S + + + +T ++ +A + G V + A++
Sbjct: 24153 D-KRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVETVDAVKAAE 24211
Query: 2048 ASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQV 2107
PP K+ + S T A + W + P H GSR+ V
Sbjct: 24212 PPSPPGKVTLTDVSQTS---------------ASLMWEK-----PEHD--GGSRVLGYVV 24249
Query: 2108 SPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSY-----------------TPVPGS 2150
G E S E+ + +V+ G SG Y VP
Sbjct: 24250 EMQPKG-----TEKWSIVAESKVCNAVVTGLSSGQEYQFRVKAYNEKGKSDPRVLGVPVI 24304
Query: 2151 TRPIRIEPS------SSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH----- 2199
+ + I+PS + + G+ L + V G+ ++W K G L + +
Sbjct: 24305 AKDLTIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETA 24364
Query: 2200 -GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSS 2254
++L + + D G+Y ++G ++ V + P P+ PVR + S+
Sbjct: 24365 TSTVLHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGP-PVGPVRFDEVSA 24419
Score = 42.7 bits (99), Expect = 0.008
Identities = 158/841 (18%), Positives = 292/841 (34%), Gaps = 146/841 (17%)
Query: 2826 APPIRIEPSSSRVA---EGQTLDLKCVVPGQAHAQVTWHKRGGNLP---ARHQVHGPLLR 2879
AP ++P V G+T L+ + G+ V W K G L AR ++ + +
Sbjct: 24704 APNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSKDGKELEETAARMEIKSTIQK 24763
Query: 2880 LNQVSP----ADSGEYSCQVTGSSGTLEASVLVTI--EPSSP-GPIPAPGLAQPIYIEAS 2932
V D G+Y +++ GT + V + P P GP+ G+ A
Sbjct: 24764 TTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGPPEGPLKVTGVTAEKCYLAW 24823
Query: 2933 SSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCR 2992
+ + +G + ++ + ++++W + T L + EY+ R
Sbjct: 24824 NPPLQDGGANISHYIIEKRETSRLSW--------TQVSTEVQALNYKVTKLLPGNEYIFR 24875
Query: 2993 AAS----GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDG 3048
+ G G E+ P + + Y+ P S S+ + ++ + DG
Sbjct: 24876 VMAVNKYGIGEPLESG-----PVTACNPYKPPGPP-STPEVSAITKDSMVVTWARPVDDG 24929
Query: 3049 AAPIS-----------LEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAY 3097
I + W N++ ++ + + G + +R A NA
Sbjct: 24930 GTEIEGYILEKRDKEGVRWTKCNKKTLTDLRLR-------VTGLTEGHSYEFRVAAENAA 24982
Query: 3098 GVAQSVVNLSVHGPPTVSVLPEGP----------------VWVKV---GKAVTLECVSAG 3138
GV + SV ++ P GP W K G A V
Sbjct: 24983 GVGEPS-EPSVFYRACDALYPPGPPSNPKVTDTSRSSVSLAWSKPIYDGGAPVKGYVVEV 25041
Query: 3139 EPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQV 3198
+ ++ WT + P L+ + + ++ K + + A N+ G +
Sbjct: 25042 KEAAADEWTTCTP-PTGLQGKQF---------TVTKLKENTEYNFRICAINSEGVGEP-- 25089
Query: 3199 EVIVDTGAMAPGA----PQVQAEEAELTVEAGHTATLRCSAT--------GSPAPTIHWS 3246
A PG+ +++ E EL + LR SAT G P P + W
Sbjct: 25090 -------ATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWE 25142
Query: 3247 KLRSPLPWQHRLEGDT----LIIPRVAQQDSGQYICNATSPAGHAEATI---ILHVESPP 3299
K L + ++E + L+I V + DSG+Y + +G A + +L S P
Sbjct: 25143 KAEGILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAP 25202
Query: 3300 YATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNE----LLHFERA 3355
T+ E + + + G + + ++ AT N E
Sbjct: 25203 VNLTIREVKKDSVTLSWEPPLIDGGAKITNYIVEKRETTRKAYATITNNCTKTTFRIENL 25262
Query: 3356 APEDSGRYRCRVTNKVG---SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKS 3412
S +R +N+ G AE + V PP +P G V VT
Sbjct: 25263 QEGCSYYFRVLASNEYGIGLPAETTEPVKVSEPP-------LPPGRVTLVDVTRNT---- 25311
Query: 3413 IGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQG-----TYICQ 3467
A++++ SD G+++ + Q G +++ L+ + G Y+ +
Sbjct: 25312 --ATIKWE-KPESDGGSKITGYVVEMQ-TKGSEKWSTCTQVKTLEATISGLTAGEEYVFR 25367
Query: 3468 AHGPWGKAQASAQLVIQALPSVLINIRTSVQ------TVVVGHAVEFECLALGDPKPQVT 3521
K ++ + + + + I I+ SV+ V ++ + G P+ V
Sbjct: 25368 VAAVNEKGRSDPRQLGVPVIARDIEIKPSVELPFHTFNVKAREQLKIDVPFKGRPQATVN 25427
Query: 3522 WSKVGGHL----RPGIVQSGGVVRIAHVELA--DAGQYRCTATNAAGTTQSHVLLLVQAL 3575
W K G L R + S V ++ E + D G Y +N+AG+ + ++V
Sbjct: 25428 WRKDGQTLKETTRVNVSSSKTVTSLSIKEASKEDVGTYELCVSNSAGSITVPITIIVLDR 25487
Query: 3576 P 3576
P
Sbjct: 25488 P 25488
Score = 42.0 bits (97), Expect = 0.013
Identities = 24/82 (29%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP VT E ++A+ G +V+ C G P ++W + P TL
Sbjct: 6078 PPYFVTE-LEPLEAAVGDSVSLQCQVAGTPEITVSWYKGDTKLRPTPEYRTYFTNNVATL 6136
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
+ V +D G YTC+A N+ G
Sbjct: 6137 VFNKVNINDSGEYTCKAENSIG 6158
Score = 42.0 bits (97), Expect = 0.013
Identities = 39/192 (20%), Positives = 74/192 (38%), Gaps = 12/192 (6%)
Query: 1953 GGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD---IAT 2009
G P ++ + G +L C+ G P I W + G L + + + T
Sbjct: 30530 GEAPGIRKEMKDVTTKLGEAAQLSCQIVGRPLPDIKWYRFGKELIQSRKYKMSSDGRTHT 30589
Query: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLD 2069
L + D G Y C+AT+ G + ++++ + P E +V G TL
Sbjct: 30590 LTVMTEEQEDEGVYTCIATNEVGEVETSSKLLLQATPQFHPGYPLKEKYYGAV--GSTLR 30647
Query: 2070 LNCVVAGSAHAQVTWY------RRGGSLPPHTQVHGSRLRLPQVS-PADSGEYVCRVENG 2122
L+ + G +TW+ + ++ H + L + V +G+Y ++ N
Sbjct: 30648 LHVMYIGRPVPAMTWFHGQKLLQNSENITIENTEHYTHLVMKNVQRKTHAGKYKVQLSNV 30707
Query: 2123 SGPKEASITVSV 2134
G +A + V +
Sbjct: 30708 FGTVDAILDVEI 30719
Score = 42.0 bits (97), Expect = 0.013
Identities = 68/330 (20%), Positives = 114/330 (34%), Gaps = 59/330 (17%)
Query: 1958 VQVSPERTQV-HA----GRTVRLYCRAAGVPSAT-ITWRKEGGSLPPQARSERT---DIA 2008
+++ P Q+ HA G V+ C+ +T +TW L + E T +A
Sbjct: 31565 IEIGPVSGQIMHAVGEEGGHVKYVCKIENYDQSTQVTWYFGVRQLENSEKYEITYEDGVA 31624
Query: 2009 TLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDA-------------------- 2048
L + IT D G Y C + G + ++ V +
Sbjct: 31625 ILYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMR 31684
Query: 2049 ---SPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPP---------HTQ 2096
PP + + + G+ + + VTWY+ G + P +
Sbjct: 31685 LLERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESD 31744
Query: 2097 VHGSRLRLPQVSPADSGEY--VCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPI 2154
+L + V+ D EY V R + G +A +TV+ LH P + RP+
Sbjct: 31745 KGLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVT-LHP-------PPTDSTLRPM 31796
Query: 2155 -RIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL---PARHQTHGSL----LRLH 2206
+ +++ EGQ++ V G + W K G L P H L L +
Sbjct: 31797 FKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIR 31856
Query: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTIE 2236
P D+G Y T+G + +E
Sbjct: 31857 DTLPEDTGYYRVTATNTAGSTSCQAHLQVE 31886
Score = 42.0 bits (97), Expect = 0.013
Identities = 23/80 (28%), Positives = 39/80 (48%), Gaps = 1/80 (1%)
Query: 407 QVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLII 466
+++T PR S+ G++ F+C G P P + W + + R VT+ + T I
Sbjct: 32562 RILTKPR-SMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEI 32620
Query: 467 RDVKESDQGAYTCEAMNARG 486
V+ SD+G Y+ N+ G
Sbjct: 32621 SSVQASDEGNYSVVVENSEG 32640
Score = 41.6 bits (96), Expect = 0.018
Identities = 28/83 (33%), Positives = 36/83 (43%), Gaps = 2/83 (2%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P +V P E ++ G+T F C G P P +NW LN I R V +G L
Sbjct: 1841 PDIVLYP-EPVRVLEGETARFRCRVTGYPQPKVNWYLNGQLIRKSKRFRVRYDGIH-YLD 1898
Query: 466 IRDVKESDQGAYTCEAMNARGMV 488
I D K D G A N G++
Sbjct: 1899 IVDCKSYDTGEVKVTAENPEGVI 1921
Score = 41.6 bits (96), Expect = 0.018
Identities = 66/287 (22%), Positives = 107/287 (37%), Gaps = 37/287 (12%)
Query: 3502 VGHAVEFECLALGDPKPQVT-WSKVGGHLRPG----IVQSGG--VVRIAHVELADAGQYR 3554
VG + FECL P +T W K G ++R + G + I V+L+DAG+Y
Sbjct: 11132 VGSSAIFECLV--SPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYT 11189
Query: 3555 CTATNAAGTTQSHVLLLVQALP---QISMPQEVRVPAGSAAVFPCIASGYPTPDISWSK- 3610
C S L+V+ LP ++ +EV V G C + D+ W K
Sbjct: 11190 CVLRLGNKEKTSTAKLVVEELPVRFVKTLEEEVTVVKGQPLYLSCELN--KERDVVWRKD 11247
Query: 3611 ------LDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVP 3664
G + P L + DAGTY T N ++ + ++V E +
Sbjct: 11248 GKIVVEKPGRIVPGVIGLMRALTINDADDTDAGTYTVTVEN-ANNLECSSCVKVVEVIRD 11306
Query: 3665 YFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSA---DGMLLYNGQKRVPGSPTNLAN--R 3719
+ + I+D + K + F D A + + G +P P + R
Sbjct: 11307 WLVK---------PIRDQHVKPKGTAIFACDIAKDTPNIKWFKGYDEIPAEPNDKTEILR 11357
Query: 3720 QPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSL 3766
+ + + PE + + R+P L LG V LL+ +
Sbjct: 11358 DGNHLYLKIKNAMPEDIAEYAVEIEGKRYPAKLTLGE-REVELLKPI 11403
Score = 41.6 bits (96), Expect = 0.018
Identities = 33/99 (33%), Positives = 45/99 (45%), Gaps = 7/99 (7%)
Query: 1967 VHAGRTVRLYCRAA-GVPSATITWRKEGGSLPPQARSERTDIAT---LLIPAITTADAGF 2022
+ AG T+ L + G P +W K G + P ++ T T L I T DAG
Sbjct: 20390 IKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITSTPTSSMLTIKYATRKDAGE 20449
Query: 2023 YLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPS 2061
Y AT+P GT ++V VL D PP +E S+ S
Sbjct: 20450 YTITATNPFGTKVEHVKVTVL---DVPGPPGPVEISNVS 20485
Score = 41.6 bits (96), Expect = 0.018
Identities = 24/85 (28%), Positives = 38/85 (44%), Gaps = 6/85 (7%)
Query: 3309 SVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA------TARNELLHFERAAPEDSGR 3362
S+QAGE ++++ G P W + G L TA + +LH + +D G+
Sbjct: 24322 SIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDFGK 24381
Query: 3363 YRCRVTNKVGSAEAFAQLLVQGPPG 3387
Y TN G+A ++V PG
Sbjct: 24382 YTVTATNSAGTATENLSVIVLEKPG 24406
Score = 41.6 bits (96), Expect = 0.018
Identities = 49/265 (18%), Positives = 93/265 (35%), Gaps = 42/265 (15%)
Query: 2585 LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQG-------------------SGSSHV 2625
L + +T D G Y C V N G + + ++G + + +
Sbjct: 31626 LYVKDITKLDDGTYRCKVVNDYGEDSSYAELFVKGVREVYDYYCRRTMKKIKRRTDTMRL 31685
Query: 2626 PSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP----SRHQTHGSHL 2681
P + + T G+ + + P+ +TWYK G + + T S
Sbjct: 31686 LERPPEFTLPLYNKTAYVGENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDK 31745
Query: 2682 RLHQMSV-----ADSGEYVCRANNNI--DALEASIVISVSPSAGSPSAPGSSMPI-RIES 2733
L+Q+++ D EY A N D+ +A + +++ P P + P+ +
Sbjct: 31746 GLYQLTINSVTTDDDAEYTVVARNKYGEDSCKAKLTVTLHP----PPTDSTLRPMFKRLL 31801
Query: 2734 SSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLP-------SHHQTRGSRLRLHHVSPA 2786
+++ EG+++ V G + W K G L H L + P
Sbjct: 31802 ANAECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPE 31861
Query: 2787 DSGEYVCRVMGSSGPLEASVLVTIE 2811
D+G Y ++G + +E
Sbjct: 31862 DTGYYRVTATNTAGSTSCQAHLQVE 31886
Score = 41.2 bits (95), Expect = 0.023
Identities = 22/83 (26%), Positives = 38/83 (45%), Gaps = 2/83 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP+++ P + +I+A G+ + G P P W+ + + + V
Sbjct: 18898 LPPKILMPEQITIKA--GKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSI 18955
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
LII+DV D G Y+ A N+ G
Sbjct: 18956 LIIKDVTRKDSGYYSLTAENSSG 18978
Score = 40.8 bits (94), Expect = 0.030
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 2/79 (2%)
Query: 410 TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSH--PRVTVTSEGGRGTLIIR 467
T P +S+ G T TF G P P ++W + I + P V ++ GR L I
Sbjct: 9 TQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIP 68
Query: 468 DVKESDQGAYTCEAMNARG 486
V +++ G Y+ +A N G
Sbjct: 69 AVTKANSGRYSLKATNGSG 87
Score = 40.8 bits (94), Expect = 0.030
Identities = 234/1184 (19%), Positives = 398/1184 (33%), Gaps = 195/1184 (16%)
Query: 2325 VTGTQGANLAYPAGSTQPI----RIEPSS----------SQVAEGQTLDLNCVVPGQSHA 2370
V A + PA +P+ R+EP + G TL L+ ++ G
Sbjct: 17189 VLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGVPFP 17248
Query: 2371 QVTWHKRGGSLPVRHQTH----GSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIE- 2425
+VTW K P + + GS L + A+ D G Y +T+E
Sbjct: 17249 KVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYS---------------LTVEN 17293
Query: 2426 PAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKR---GGSLPARHQ 2482
PAGS T +V++ G DL + +TW + GGS+ +
Sbjct: 17294 PAGSK-----TVSVKVLVLDKP---GPPRDLEVSEIRKDSCYLTWKEPLDDGGSVITNYV 17345
Query: 2483 VHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSS 2542
V + Q +P + + L + V P I++
Sbjct: 17346 VERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRGPFVETPKPIKALD 17405
Query: 2543 ASLANGHTLDLNCLVASQAPHTITWYK--RGGSLPSRHQIV-----GSRLRIPQVTPADS 2595
G DL+ + + ++ W K R G P +V G++ I T +
Sbjct: 17406 PLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSPITGYLVEYQEEGTQDWIKFKTVTNL 17465
Query: 2596 GEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRI-ESSSPTVVE----------- 2643
V + G R I G G +P + PI E P VE
Sbjct: 17466 ECVVTGLQQGKTYRFRVKAENIVGLG---LPDTTIPIECQEKLVPPSVELDVKLIEGLVV 17522
Query: 2644 --GQTLDLNCVVARQPQAIITWYKRGGSLPS-RHQT-----HGSHLRLHQMSVADSGEYV 2695
G T+ ++ P W G + + H T S L + D+GEY
Sbjct: 17523 KAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEYQ 17582
Query: 2696 CRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIE----SSSSHVAEGETLDLNCVVP 2751
+N + ++ ++V G P+ P + + + E S +G + +N +V
Sbjct: 17583 ITVSNAAGSKTVAVHLTVLDVPGPPTGPINILDVTPEHMTISWQPPKDDGGSPVINYIVE 17642
Query: 2752 GQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
Q + TW G + S ++L++ H+ EYV RV + + V ++
Sbjct: 17643 KQDTRKDTW----GVVSSGSSK--TKLKIPHLQKGC--EYVFRVRAEN---KIGVGPPLD 17691
Query: 2812 ASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARH 2871
++ + A H +P P +P + + E + + +T G R
Sbjct: 17692 STPTVAKHKFSPPSPPG---KPVVTDITENAATVSWTLPKSDGGSPIT-----GYYMERR 17743
Query: 2872 QVHGPLLRLNQVSPADSGEYSCQVTG--SSGTLEASV-------LVTIEPSS-------- 2914
+V G +R+N+ AD +VTG T E V L PSS
Sbjct: 17744 EVTGKWVRVNKTPIAD---LKFRVTGLYEGNTYEFRVFAENLAGLSKPSPSSDPIKACRP 17800
Query: 2915 ---PGPIPAPGLAQPIYIEAS---SSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR 2968
PGP P L A + +++G + L VV Q W + R
Sbjct: 17801 IKPPGPPINPKLKDKSRETADLVWTKPLSDGGSPILGYVVECQKPGTAQWNRINKDELIR 17860
Query: 2969 HQTHGSQLRLHLVSPADSGEYVCRAAS----GPGPEQEASFTVTVPPSEGSSYRLRSPVI 3024
Q + + EY R + G G +E + +V L P +
Sbjct: 17861 ------QCAFRVPGLIEGNEYRFRIKAANIVGEGEPRELAESVIAKDI------LHPPEV 17908
Query: 3025 SIDPPSS---TVQQGQDASFKCLIHDGAAPISLEWKTRNQELE-----DNVHISPNGSII 3076
+D TV+ GQ + P + W + L D + P +
Sbjct: 17909 ELDVTCRDVITVRVGQTIRILARVKGRPEP-DITWTKEGKVLVREKRVDLIQDLPRVELQ 17967
Query: 3077 TIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVW-VKVGKAVTLECV 3135
R ++HG Y A N+ G AQ ++V P GP +KV C
Sbjct: 17968 IKEAVR-ADHGKYIISAKNSSGHAQGSAIVNVLDRP-------GPCQNLKVTNVTKENCT 18019
Query: 3136 SAGE---PRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTY---VCLAQN 3189
+ E + T K Q+ + ++ S ++ A Y VC A+N
Sbjct: 18020 ISWENPLDNGGSEITNFIVEYRKPNQKGWSIVASDVTKRLIKANLLANNEYYFRVC-AEN 18078
Query: 3190 ALG---TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT----GSPAPT 3242
+G T + + ++ PG P E + + L+ GSP +
Sbjct: 18079 KVGVGPTIETKTPILAINPIDRPGEP----ENLHIADKGKTFVYLKWRRPDYDGGSPNLS 18134
Query: 3243 IHWSK-LRSPLPWQHRLEGDT----LIIPRVAQQDSGQYICNATSPAGHA------EATI 3291
H + L+ W+ +G ++ R + ++ + G + E +
Sbjct: 18135 YHVERRLKGSDDWERVHKGSIKETHYMVDRCVENQIYEFRVQTKNEGGESDWVKTEEVVV 18194
Query: 3292 ILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL-- 3349
++ P + +V+AG+T++L+ G P W++ + + R ++
Sbjct: 18195 KEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDT 18254
Query: 3350 ------LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG 3387
+A D G+Y TN GS A+A + V PG
Sbjct: 18255 RADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVLDKPG 18298
Score = 40.8 bits (94), Expect = 0.030
Identities = 31/87 (35%), Positives = 41/87 (47%), Gaps = 6/87 (6%)
Query: 1969 AGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE--RTDIATLLIPAITT-ADAGFYLC 2025
AG RL +G P T+ W K+G L A+ E D +T L+ +T D+G Y
Sbjct: 21475 AGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDSTRRDSGAYTL 21534
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPP 2052
AT+P G A+ V VL D PP
Sbjct: 21535 TATNPGGFAKHIFNVKVL---DRPGPP 21558
Score = 40.8 bits (94), Expect = 0.030
Identities = 32/112 (28%), Positives = 50/112 (44%), Gaps = 4/112 (3%)
Query: 1956 PRVQVSPERTQV---HAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLL- 2011
P +++ + +V A T+RL+ G P + W K G L +A+ E T T+L
Sbjct: 25105 PEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAEGILTDRAQIEVTSSFTMLV 25164
Query: 2012 IPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVT 2063
I +T D+G Y + +G+ A + V VL + A E SVT
Sbjct: 25165 IDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNLTIREVKKDSVT 25216
Score = 40.8 bits (94), Expect = 0.030
Identities = 37/137 (27%), Positives = 53/137 (38%), Gaps = 21/137 (15%)
Query: 1674 QAPLVVEVHP---------------ARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPV 1718
+A L V +HP A + +G S +VSG PP W + DG+P+
Sbjct: 31777 KAKLTVTLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIRVSGIPPPTLKWEK-DGQPL 31835
Query: 1719 PSGTQQR--HQGSE---LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITV 1773
G H+G + LH P D G Y T N S + +A L V K
Sbjct: 31836 SLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGSTSCQAHLQVERLRYKKQEF 31895
Query: 1774 TVEEQRSQSVRPGADVT 1790
+E+ + V+ D T
Sbjct: 31896 KSKEEHERHVQKQIDKT 31912
Score = 40.4 bits (93), Expect = 0.039
Identities = 47/200 (23%), Positives = 77/200 (38%), Gaps = 27/200 (13%)
Query: 2437 PTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG-----GSLPA---RHQVHGSRL 2488
PT S V EG T ++G +V+W + G +LP ++L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 2489 RLLQVTPADSGEYVCRVVGSSG--TQEASVLVTIQQRLSGSHSQGVAYPVRIES-SSASL 2545
+ VT A+SG Y + SG T A +LV + A P ++ S ++
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVKAE----------TAPPNFVQRLQSMTV 115
Query: 2546 ANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSR------LRIPQVTPADSGEYV 2599
G + L V + +Y+ G + S S+ L I + P DSG Y
Sbjct: 116 RQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYS 175
Query: 2600 CHVSNGAGSRETSLIVTIQG 2619
+ +N G ++ + +QG
Sbjct: 176 VNATNSVGRATSTAELLVQG 195
Score = 40.4 bits (93), Expect = 0.039
Identities = 49/237 (20%), Positives = 81/237 (34%), Gaps = 63/237 (26%)
Query: 2811 EASGSSAVHVPAPGG---APPIRIEPSSS-RVAEGQTLDLKCVVPGQAHAQVTWHKRGGN 2866
EA + VPAP PP + + V EG+++ L+C + G VTW++
Sbjct: 923 EAKVTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQ 982
Query: 2867 LPA------RHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTI---------- 2910
+ + Q L + + DSG ++C +GT+ S + +
Sbjct: 983 IESSIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAGTVSTSCYLAVQVSEEFEKET 1042
Query: 2911 -----------------------------EPSSPGPIPAP-GLAQPIYIEASSSHVTEGQ 2940
E + PG AP + +P+ + EG
Sbjct: 1043 TAVTEKFTTEEKRFVESRDVVMTDTSLTEEQAGPGEPAAPYFITKPVV-----QKLVEGG 1097
Query: 2941 TLDLNCVVPGQAHAQVTWYKRGGSLPARH--------QTHGSQLRLHLVSPADSGEY 2989
++ C V G V W K G L + QT +L + + D+GEY
Sbjct: 1098 SVVFGCQVGGNPKPHVYWKKSGVPLTTGYRYKVSYNKQTGECKLVISMTFADDAGEY 1154
Score = 40.4 bits (93), Expect = 0.039
Identities = 40/167 (23%), Positives = 64/167 (38%), Gaps = 13/167 (7%)
Query: 1625 SRTCESLGAGGYRCTACEPGYTGQY-------CEQCGPGYVGNPSVQGGQCLPETNQAPL 1677
+ T ES Y+ T G T ++ + P +V P + + P L
Sbjct: 17163 NHTPESCPETKYKVTGLRDGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPE----L 17218
Query: 1678 VVEVHPARSI-VPQGGSHSLRCQVSGSPPHYFYWSRED-GRPVPSGTQQRHQGSELHFPS 1735
+++ + AR + G + L + G P W +ED P + GS+L +
Sbjct: 17219 ILDANMAREQHIKVGDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRN 17278
Query: 1736 VQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQS 1782
D G+Y T N S T ++LV + P P + V E R S
Sbjct: 17279 AAHEDGGIYSLTVENPAGSKTVSVKVLVLDKPGPPRDLEVSEIRKDS 17325
Score = 40.4 bits (93), Expect = 0.039
Identities = 26/87 (29%), Positives = 40/87 (45%), Gaps = 8/87 (9%)
Query: 3586 VPAGSAAVFPCIASGYPTPDISWSK----LDGSLPP----DSRLENNMLMLPSVRPQDAG 3637
V AG G P P+++W+K D + P D+R +++ L + D G
Sbjct: 18213 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 18272
Query: 3638 TYVCTATNRQGKVKAFAHLQVPERVVP 3664
YV TATN G A+A + V ++ P
Sbjct: 18273 KYVVTATNTAGSFVAYATVNVLDKPGP 18299
Score = 40.4 bits (93), Expect = 0.039
Identities = 35/129 (27%), Positives = 52/129 (40%), Gaps = 16/129 (12%)
Query: 3552 QYRCTATNAAGTT-----QSHVLLLVQALP-----QISMPQEVRVPAGSAAVFPCIASGY 3601
Q+R A A + V +L + +P ++M + V AG+ G
Sbjct: 19263 QFRAIARTAVNISPPSEPSDPVTILAENVPPRIDLSVAMKSLLTVKAGTNVCLDATVFGK 19322
Query: 3602 PTPDISWSKLDGSLPPDSRLENNM------LMLPSVRPQDAGTYVCTATNRQGKVKAFAH 3655
P P +SW K L P ++ M L L SV +D+G Y TA N G A
Sbjct: 19323 PMPTVSWKKDGTLLKPAEGIKMAMQRNLCTLELFSVNRKDSGDYTITAENSSGSKSATIK 19382
Query: 3656 LQVPERVVP 3664
L+V ++ P
Sbjct: 19383 LKVLDKPGP 19391
Score = 40.4 bits (93), Expect = 0.039
Identities = 158/825 (19%), Positives = 274/825 (33%), Gaps = 152/825 (18%)
Query: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ----THGSQLRLHLVSPADSGEYVC 2991
V G + ++ G+ ++TW + G + Q + +QL + D+G+Y+
Sbjct: 24036 VRAGGSARIHIPFKGRPTPEITWSREEGEFTDKVQIEKGVNYTQLSIDNCDRNDAGKYIL 24095
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCL---IHDG 3048
+ + G + A TV V + G L + + +D++F I DG
Sbjct: 24096 KLENSSG-SKSAFVTVKVLDTPGPPQNL-----------AVKEVRKDSAFLVWEPPIIDG 24143
Query: 3049 AAPIS---LEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVA---QS 3102
A + ++ + ++ NV + + + +R +A N +GV ++
Sbjct: 24144 GAKVKNYVIDKRESTRKAYANVSSKCSKTSFKVENLTEGAIYYFRVMAENEFGVGVPVET 24203
Query: 3103 VVNLSVHGPPT---------VSVLPEGPVWVKV---GKAVTLECVSAGEPRSSARWTRIS 3150
V + PP+ VS +W K G + L V +P+ + +W+ ++
Sbjct: 24204 VDAVKAAEPPSPPGKVTLTDVSQTSASLMWEKPEHDGGSRVLGYVVEMQPKGTEKWSIVA 24263
Query: 3151 STPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPG 3210
+ + + V +SS + + A N G + +V +
Sbjct: 24264 ESK----------VCNAVVTGLSSGQEYQ---FRVKAYNEKGKSDPRVLGVPVIAKDLTI 24310
Query: 3211 APQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE------GDTLI 3264
P ++ +++AG + G P P I W K PL R+ L
Sbjct: 24311 QPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLH 24370
Query: 3265 IPRVAQQDSGQYICNATSPAGHAE---ATIILHVESPPYATTVPEHASVQ---------- 3311
I + D G+Y AT+ AG A + I+L PP + S
Sbjct: 24371 IKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEPPA 24430
Query: 3312 -AGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNK 3370
G + T W V AT + + ++R N+
Sbjct: 24431 YTGGCQISNYIVEKRDTTTTTWHMVS------ATVARTTIKITKLKTGTEYQFRIFAENR 24484
Query: 3371 VGSAEAF--AQLLVQ------GPPGSLPATSIPAGSTPTVQVTPQLE--TKSIGASVEFH 3420
G + ++VQ GPPG+ TSI P + TK IG +E
Sbjct: 24485 YGKSAPLDSKAVIVQYPFKEPGPPGTPFVTSISKDQMLVQWHEPVNDGGTKIIGYHLE-- 24542
Query: 3421 CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHG--PWGKAQAS 3478
+ W K +QD + LD+ + + A GK
Sbjct: 24543 ----QKEKNSILWVKLNKT-----PIQDTKFKTTGLDEGLEYEFKVSAENIVGIGKPSKV 24593
Query: 3479 AQLVI-------QALPSVLINIRTSVQ-----------TVVVGHAVEFECLALGDPKPQV 3520
++ + P ++ R +V + + G+ VE + L P
Sbjct: 24594 SECFVARDPCDPPGRPEAIVITRNNVTLKWKKPAYDGGSKITGYIVEKKDL------PDG 24647
Query: 3521 TWSKVG--GHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAG--TTQSHVLLLVQALP 3576
W K L SG V + ++R A NAAG + S + A
Sbjct: 24648 RWMKASFTNVLETEFTVSGLVEDQRY-------EFRVIARNAAGNFSEPSDSSGAITARD 24700
Query: 3577 QISMPQE---------VRVPAGSAAVFPCIASGYPTPDISWSKLDGS--------LPPDS 3619
+I P + V AG V G P PD+ WSK DG + S
Sbjct: 24701 EIDAPNASLDPKYKDVIVVHAGETFVLEADIRGKPIPDVVWSK-DGKELEETAARMEIKS 24759
Query: 3620 RLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVP 3664
++ L++ D G Y+ +N G ++V +R P
Sbjct: 24760 TIQKTTLVVKDCIRTDGGQYILKLSNVGGTKSIPITVKVLDRPGP 24804
Score = 40.0 bits (92), Expect = 0.051
Identities = 24/79 (30%), Positives = 35/79 (44%)
Query: 3124 VKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTY 3183
VK G + L G+P WT+ + ++ T + + + I +K SD GTY
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 13761
Query: 3184 VCLAQNALGTAQKQVEVIV 3202
+ A N G A VEV V
Sbjct: 13762 IIEAVNVCGRATAVVEVNV 13780
Score = 40.0 bits (92), Expect = 0.051
Identities = 77/404 (19%), Positives = 152/404 (37%), Gaps = 53/404 (13%)
Query: 2838 VAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQV----SPADSGEYSC 2893
V G + + V G+ VTW+ LP + + + V + G YS
Sbjct: 16536 VHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSL 16595
Query: 2894 QVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASS----SHVTEGQTLDLNCVVP 2949
+G + +++V + PGP+ P LA + E+ S +G + N V+
Sbjct: 16596 LAKNEAGERKKTIIVDVL-DVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPITNYVIE 16654
Query: 2950 GQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAAS----GPGPEQEASF 3005
+ + W ++ ++ T ++ Y R A+ G GP E S
Sbjct: 16655 KRESDRRAWTPVTYTVTRQNATVQGLIQ--------GKAYFFRIAAENSIGMGPFVETSE 16706
Query: 3006 TVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI-----HDGAAPISLEWKTRN 3060
+ + R P+ + P + + L +DG + I + + +
Sbjct: 16707 ALVI----------REPITVPERPEDLEVKEVTKNTVTLTWNPPKYDGGSEI-INYVLES 16755
Query: 3061 QEL-EDNVHISPNGSII----TIVGTRPSNHGTYRCVASNAYG------VAQSVVNLSVH 3109
+ + + H N +++ T+ G + + YR A N G + +
Sbjct: 16756 RLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCKDEL 16815
Query: 3110 GPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAV 3169
PPT+ + + ++VG+A L +G+P+ W + + + ++ +
Sbjct: 16816 APPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPATLA 16875
Query: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEV-IVDTGAMAPGAP 3212
L+ AK SD+G Y + +N+ G+ + +V +VD PG P
Sbjct: 16876 LEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVD----RPGPP 16915
Score = 40.0 bits (92), Expect = 0.051
Identities = 47/202 (23%), Positives = 83/202 (41%), Gaps = 22/202 (10%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIA---TLLIPAITTADAGFY 2023
V AG +++ +G P +T ++G L R A T+ + TADAG Y
Sbjct: 26488 VRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKESVTADAGRY 26547
Query: 2024 LCVATSPAGTAQARIQVVVLSASDASPPPVKI-ESSSPSVT--------EGQTLDLNCVV 2074
A + +GT +A I +VVL PV I + + SVT +G + N ++
Sbjct: 26548 EITAANSSGTTKAFINIVVLDRPGPPTGPVVISDITEESVTLKWEPPKYDGGSQVTNYIL 26607
Query: 2075 AGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKE----ASI 2130
+ W + V + +++ +++ + ++ + EN G + A +
Sbjct: 26608 LKRETSTAVWTEVSAT------VARTMMKVMKLTTGEEYQFRIKAENRFGISDHIDSACV 26661
Query: 2131 TVSVLHGTHSGPSYTPVPGSTR 2152
TV + + T PS V TR
Sbjct: 26662 TVKLPYTTPGPPSTPWVTNVTR 26683
Score = 40.0 bits (92), Expect = 0.051
Identities = 23/85 (27%), Positives = 37/85 (43%), Gaps = 2/85 (2%)
Query: 404 MPPQVVTPPR--ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR 461
+PP V P + + G+++ + G P P + W + I + +T G
Sbjct: 27954 VPPIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGS 28013
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
+L +RD +G YT EA NA G
Sbjct: 28014 TSLFVRDATRDHRGVYTVEAKNASG 28038
Score = 40.0 bits (92), Expect = 0.051
Identities = 27/105 (25%), Positives = 47/105 (44%), Gaps = 6/105 (5%)
Query: 1956 PRVQVSPERTQ---VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDI---AT 2009
P V+ PE + +G ++R+ G P +TW K+G + + E TD+ +
Sbjct: 27956 PIVEFGPEYFDGLIIKSGESLRIKALVQGRPVPRVTWFKDGVEIEKRMNMEITDVLGSTS 28015
Query: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVK 2054
L + T G Y A + +G+A+A I+V V P++
Sbjct: 28016 LFVRDATRDHRGVYTVEAKNASGSAKAEIKVKVQDTPGKVVGPIR 28060
Score = 39.7 bits (91), Expect = 0.067
Identities = 52/210 (24%), Positives = 83/210 (39%), Gaps = 30/210 (14%)
Query: 2722 APGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRG-----GSLPS---HHQT 2773
AP + P++ S V EG T + G +V+W + G +LP
Sbjct: 5 APTFTQPLQ----SVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSD 60
Query: 2774 RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEP 2833
++L + V+ A+SG Y + SG +A+ ++ + V A P
Sbjct: 61 GRAKLTIPAVTKANSGRYSLKATNGSG----------QATSTAELLVKAETAPPNFVQRL 110
Query: 2834 SSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA----RHQVHGPL--LRLNQVSPAD 2887
S V +G + L+ V G V +++ G + + + G L L + + P D
Sbjct: 111 QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPED 170
Query: 2888 SGEYSCQVTGSSG--TLEASVLVTIEPSSP 2915
SG YS T S G T A +LV E P
Sbjct: 171 SGTYSVNATNSVGRATSTAELLVQGEEEVP 200
Score = 39.7 bits (91), Expect = 0.067
Identities = 83/401 (20%), Positives = 138/401 (34%), Gaps = 77/401 (19%)
Query: 2597 EYVCHVS--NGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVA 2654
EYV V N G E S I + + P P I +E+ V+EG+ L +
Sbjct: 14355 EYVLRVRAVNAIGVSEPS---EISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFR 14411
Query: 2655 RQPQAIITWYKRG------GSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEAS 2708
P ++W+K G L ++ +HL + + AD+G Y N + + AS
Sbjct: 14412 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 14471
Query: 2709 IVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHK---RGG 2765
I + V G P G D+ ++ ++TW GG
Sbjct: 14472 INVKV---IGLP--------------------GPCKDIKASDITKSSCKLTWEPPEFDGG 14508
Query: 2766 SLPSHHQTRGSRLRLHHVSPADSGE----YVCRVMGSSGPLEASVLVTIEASGSSAVHVP 2821
+ H+ P SGE + + + +G V + G + +
Sbjct: 14509 TPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELK 14568
Query: 2822 APGGA--------PPIRIEPSSSRVAEGQTLDLK------------CVVPGQAHAQVTWH 2861
P A PP+ +E + AE T+ K ++ A + W
Sbjct: 14569 NPVIAQDPKQPPDPPVDVEVHNP-TAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWK 14627
Query: 2862 KRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQV--TGSSGTLEASVLVTIEPSSPGPIP 2919
+ +L P+L + EY +V ++G E S T + PI
Sbjct: 14628 RCNEHLV-------PILTYTAKGLEEGKEYQFRVRAENAAGISEPS-RATPPTKAVDPID 14679
Query: 2920 APGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK 2960
AP + I +S V G + L+ + G + +TW K
Sbjct: 14680 APKV-----ILRTSLEVKRGDEIALDASISGSPYPTITWIK 14715
Score = 39.7 bits (91), Expect = 0.067
Identities = 36/132 (27%), Positives = 59/132 (44%), Gaps = 26/132 (19%)
Query: 3552 QYRCTATNAAG------TTQSHVLLLVQALPQISMP---QEVRV-PAGSAAVFPCIASGY 3601
++R A N AG TT +Q P++ + Q+ V AGS P + G
Sbjct: 15778 RFRVKAVNEAGESEPSDTTGEIPATDIQEEPEVFIDIGAQDCLVCKAGSQIRIPAVIKGR 15837
Query: 3602 PTPDISWSKLDG-----------SLPPDSRLE----NNMLMLPSVRPQDAGTYVCTATNR 3646
PTP SW + DG +P D++LE ++++++P + G Y TA N+
Sbjct: 15838 PTPKSSW-EFDGKAKKAMKDGVHDIPEDAQLETAENSSVIIIPECKRSHTGKYSITAKNK 15896
Query: 3647 QGKVKAFAHLQV 3658
G+ A ++V
Sbjct: 15897 AGQKTANCRVKV 15908
Score = 39.7 bits (91), Expect = 0.067
Identities = 19/55 (34%), Positives = 28/55 (50%)
Query: 432 GVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
G P P ++W+ + + RV+V S TLI+ D ++SD G YT N G
Sbjct: 20008 GKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAG 20062
Score = 39.7 bits (91), Expect = 0.067
Identities = 169/891 (18%), Positives = 293/891 (32%), Gaps = 149/891 (16%)
Query: 2826 APPIRIEPSSSR---VAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHG----PLL 2878
AP + I+ + + V G ++ L G+ W K NL R +H L
Sbjct: 28354 APELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTL 28413
Query: 2879 RLNQVSPADSGEYSCQVTGSSG--TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHV 2936
+ + D+G+Y+ V +SG ++ +V V P PGPI + + + +
Sbjct: 28414 TVENCNRNDAGKYTLTVENNSGSKSITFTVKVLDTPGPPGPITFKDVTRGSATLMWDAPL 28473
Query: 2937 TEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASG 2996
+G + VV + ++ +W Q + + D E
Sbjct: 28474 LDGGARIHHYVVEKREASRRSW-----------QVISEKCTRQIFKVNDLAE-------- 28514
Query: 2997 PGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPS-----STVQQGQDASFKCLI---HDG 3048
G + G Y + P+++ + P+ V + ++ + HDG
Sbjct: 28515 -GVPYYFRVSAVNEYGVGEPYEMPEPIVATEQPAPPRRLDVVDTSKSSAVLAWLKPDHDG 28573
Query: 3049 AAPISLEWKTRNQELEDNVHISPNGSIITIVGTR--PSNHGTYRCVASNAYGVAQ----- 3101
+ I+ Q+ D + + +T R +R A N G ++
Sbjct: 28574 GSRITGYLLEMRQKGSDFWVEAGHTKQLTFTVERLVEKTEYEFRVKAKNDAGYSEPREAF 28633
Query: 3102 -SVVNLSVHGPPTVSV--LPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ 3158
SV+ PT + + + K G T++ +G P W + ++
Sbjct: 28634 SSVIIKEPQIEPTADLTGITNQLITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDR 28693
Query: 3159 RTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAP--GAPQVQA 3216
+ L + + D+G Y +N G V V+V G P G +V +
Sbjct: 28694 VSITTTKDRTTLTVKDSMRGDSGRYFLTLENTAGVKTFSVTVVV-IGRPGPVTGPIEVSS 28752
Query: 3217 EEAELTV-------EAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVA 3269
AE V + G T + T W + S + +
Sbjct: 28753 VSAESCVLSWGEPKDGGGTEITNYIVEKRESGTTAWQLVNSSVKRTQIKVTHLTKYMEYS 28812
Query: 3270 QQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLT 3329
+ S + + P A I H PP A T PE V A ++
Sbjct: 28813 FRVSSENRFGVSKPLESA-PIIAEHPFVPPSAPTRPEVYHVSAN-------------AMS 28858
Query: 3330 FQWSRV----GSSLPG---RATARNELLHF-ERAAP------EDSG-------RYRCRVT 3368
+W GS + G RN +L E P + +G ++R
Sbjct: 28859 IRWEEPYHDGGSKIIGYWVEKKERNTILWVKENKVPCLECNYKVTGLVEGLEYQFRTYAL 28918
Query: 3369 NKVG---SAEAFAQLLVQGP---PGSLPATSIPAGSTPTVQVTPQLE--TKSIGASVEFH 3420
N G ++EA ++ Q P PG T + + + P + +K +G +E
Sbjct: 28919 NAAGVSKASEASRPIMAQNPVDAPGRPEVTDVTRSTVSLIWSAPAYDGGSKVVGYIIE-- 28976
Query: 3421 CAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTY-----ICQAHGPWGKA 3475
P RW K + V D + L + TY A G K
Sbjct: 28977 -RKPVSEVGDGRWLKCNYTI-----VSDNFFTVTALSEG--DTYEFRVLAKNAAGVISKG 29028
Query: 3476 QASAQLVI----QALPSVLINIRT--SVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHL 3529
S V A P ++ R + T+ G + + G P+P++ W+K L
Sbjct: 29029 SESTGPVTCRDEYAPPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKEL 29088
Query: 3530 ----RPGIVQSG--GVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALP------- 3576
+ + +G I + +D+G+Y T NA+GT V++ V P
Sbjct: 29089 DLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTVKNASGTKAVSVMVKVLDSPGPCGKLT 29148
Query: 3577 -----------QISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLP 3616
S+PQE G A + I T ++W ++G P
Sbjct: 29149 VSRVTQEKCTLAWSLPQE----DGGAEITHYIVERRETSRLNWVIVEGECP 29195
Score = 39.3 bits (90), Expect = 0.087
Identities = 30/102 (29%), Positives = 45/102 (44%), Gaps = 8/102 (7%)
Query: 1667 QCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSG----- 1721
Q P AP + + +V +GGS CQV G+P + YW ++ G P+ +G
Sbjct: 1073 QAGPGEPAAPYFITKPVVQKLV-EGGSVVFGCQVGGNPKPHVYW-KKSGVPLTTGYRYKV 1130
Query: 1722 TQQRHQGS-ELHFPSVQPSDAGVYICTCRNLHQSNTSRAELL 1762
+ + G +L DAG Y RN H ++ A LL
Sbjct: 1131 SYNKQTGECKLVISMTFADDAGEYTIVVRNKHGETSASASLL 1172
Score = 39.3 bits (90), Expect = 0.087
Identities = 32/115 (27%), Positives = 43/115 (37%), Gaps = 8/115 (6%)
Query: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAI 431
Q+ C ++N AS + P +S F P SI G++ F C
Sbjct: 6244 QYSCSASNPLGTASSSARLTAREPKKSPFFDIKPV--------SIDVIAGESADFECHVT 6295
Query: 432 GVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
G I W + I T+T G L I V + D G YTC+A N G
Sbjct: 6296 GAQPMRITWSKDNKEIRPGGNYTITCVGNTPHLRILKVGKGDSGQYTCQATNDVG 6350
Score = 39.3 bits (90), Expect = 0.087
Identities = 28/103 (27%), Positives = 43/103 (41%), Gaps = 4/103 (3%)
Query: 405 PPQVVTPP--RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
PP+V R+ I GQT+ G P P I W + RV + + R
Sbjct: 17905 PPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWTKEGKVLVREKRVDLIQDLPRV 17964
Query: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPC 505
L I++ +D G Y A N+ G G ++ ++ + GPC
Sbjct: 17965 ELQIKEAVRADHGKYIISAKNSSGHAQG--SAIVNVLDRPGPC 18005
Score = 39.3 bits (90), Expect = 0.087
Identities = 22/79 (27%), Positives = 36/79 (45%), Gaps = 6/79 (7%)
Query: 3576 PQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL------ENNMLMLP 3629
P+I MP+++ + AG G P P W K + + S L +++L++
Sbjct: 18900 PKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIK 18959
Query: 3630 SVRPQDAGTYVCTATNRQG 3648
V +D+G Y TA N G
Sbjct: 18960 DVTRKDSGYYSLTAENSSG 18978
Score = 39.3 bits (90), Expect = 0.087
Identities = 102/480 (21%), Positives = 179/480 (37%), Gaps = 70/480 (14%)
Query: 2050 PPPVKIESSSPSVTEGQ---TLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSR----L 2102
PP +++++ V + TL L + G +V W R G + + L
Sbjct: 21857 PPEIELDADLRKVVTIRACCTLRLFVPIKGRPAPEVKWARDHGESLDKASIESTSSYTLL 21916
Query: 2103 RLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSH 2162
+ V+ DSG+Y+ VEN SG K A + V VL T P V T+
Sbjct: 21917 IVGNVNRFDSGKYILTVENSSGSKSAFVNVRVL-DTPGPPQDLKVKEVTKTSVTLTWDPP 21975
Query: 2163 VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVG 2222
+ +G + N +V + + + + H+T + +L + Y V+
Sbjct: 21976 LLDGGSKIKNYIVEKRESTRKAYSTVATNC---HKTSWKVDQLQ-----EGCSYYFRVLA 22027
Query: 2223 TSG---PLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY 2279
+ L A +++AS P+PP +I T + ++W
Sbjct: 22028 ENEYGIGLPAETAESVKAS--ERPLPPGKITLMDVT---------------RNSVSLSWE 22070
Query: 2280 K---RGGS----LPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGAN 2332
K GGS Q +GS + A+ + G E S V+ +G +
Sbjct: 22071 KPEHDGGSRILGYIVEMQTKGSDKWATCATVKVTEATITGLIQGEEYSFRVSAQNEKGIS 22130
Query: 2333 ----LAYPAGSTQPIRIEP------SSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLP 2382
L+ P + + I P ++ V G+ L ++ G+ VTWHK ++P
Sbjct: 22131 DPRQLSVPV-IAKDLVIPPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHK--DNVP 22187
Query: 2383 VRHQT--------HGSLLRLYQASPADSGEYVCRVLGSS-VPLEASVLVTIE----PAGS 2429
++ T + SLL + A D G YV ++ S+ +E ++ ++ P G
Sbjct: 22188 LKQTTRVNAESTENNSLLTIKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGPPTGP 22247
Query: 2430 VPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLR 2489
V VT S +G + N +V + + TW ++ AR + RL+
Sbjct: 22248 VKMDEVTADSITLSWGPPKYDGGSSINNYIVEKRDTSTTTWQIVSATV-ARTTIKACRLK 22306
Score = 39.3 bits (90), Expect = 0.087
Identities = 29/101 (28%), Positives = 42/101 (41%), Gaps = 7/101 (6%)
Query: 1956 PRVQVSPERTQVH---AGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD-IATLL 2011
P + + Q H AG ++RL+ G P+ T W K +L +A TD +TL
Sbjct: 28355 PELDIDANFKQTHVVRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLT 28414
Query: 2012 IPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPP 2052
+ DAG Y + +G+ V VL D PP
Sbjct: 28415 VENCNRNDAGKYTLTVENNSGSKSITFTVKVL---DTPGPP 28452
Score = 38.9 bits (89), Expect = 0.11
Identities = 51/215 (23%), Positives = 88/215 (40%), Gaps = 26/215 (12%)
Query: 2253 SSTVAEGQTLDLSCVVAGQAHAQVTWYKRG-----GSLPA---RHQVRGSRLYIFQASPA 2304
S V EG T ++G +V+W++ G +LP ++L I + A
Sbjct: 14 SVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKLTIPAVTKA 73
Query: 2305 DAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEP-SSSQVAEGQTLDLNCV 2363
++G+Y +A+NG + T A L A + P ++ S V +G + L
Sbjct: 74 NSGRYSLKATNG-------SGQATSTAELLVKAETAPPNFVQRLQSMTVRQGSQVRLQVR 126
Query: 2364 VPGQSHAQVTWHKRG----GSLPVRHQTHGSL--LRLYQASPADSGEYVCRVLGSSVPLE 2417
V G V +++ G SL + G L L + +A P DSG Y S
Sbjct: 127 VTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTYSVNATNSVGRAT 186
Query: 2418 ASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQ 2452
++ + ++ VPA V S++Q++E +
Sbjct: 187 STAELLVQGEEEVPAKKTKTIV----STAQISESR 217
Score = 38.9 bits (89), Expect = 0.11
Identities = 25/82 (30%), Positives = 34/82 (41%), Gaps = 1/82 (1%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP V P E ++ G+ VTFT V G P +NW + R + E L
Sbjct: 5892 PPSFVKEP-EPLEVLPGKNVTFTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAEL 5950
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
+ ++ S G YTC N G
Sbjct: 5951 ELFNIDISQSGEYTCVVSNNAG 5972
Score = 38.9 bits (89), Expect = 0.11
Identities = 62/282 (21%), Positives = 95/282 (33%), Gaps = 33/282 (11%)
Query: 2401 DSGEYVCRVL-----GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLD 2455
D Y RVL G S P V ++ P L + + E + G TL
Sbjct: 17181 DGQTYKFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQ---HIKVGDTLR 17237
Query: 2456 LNCLVAGQAHAQVTWHKRGGSLPARHQVH----GSRLRLLQVTPADSGEYVCRVVGSSGT 2511
L+ ++ G +VTW K P + ++ GS+L + D G Y V +G+
Sbjct: 17238 LSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAGS 17297
Query: 2512 QEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRG 2571
+ SV V + + V+ I S L LD IT Y
Sbjct: 17298 KTVSVKVLVLDKPGPPRDLEVS---EIRKDSCYLTWKEPLD-------DGGSVITNY--- 17344
Query: 2572 GSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPP 2631
+ R + ++ T + H++ G G G P V P
Sbjct: 17345 --VVERRDVASAQWSPLSATSKKKSHFAKHLNEGNQYLFRVAAENQYGRG----PFVETP 17398
Query: 2632 IRIESSSPTVVEGQTLDLNCVVARQPQAIITWYK--RGGSLP 2671
I++ P G DL+ V + + + W K R G P
Sbjct: 17399 KPIKALDPLHPPGPPKDLHHVDVDKTEVSLVWNKPDRDGGSP 17440
Score = 38.9 bits (89), Expect = 0.11
Identities = 30/111 (27%), Positives = 50/111 (45%), Gaps = 14/111 (12%)
Query: 3552 QYRCTATNAAGTTQ-SHV---LLLVQAL--PQI----SMPQEVRVPAGSAAVFPCIASGY 3601
++R A NAAG + +HV +L+ L P++ +M +E + G I G
Sbjct: 17186 KFRVLAVNAAGESDPAHVPEPVLVKDRLEPPELILDANMAREQHIKVGDTLRLSAIIKGV 17245
Query: 3602 PTPDISWSKLDGSLPPDSRLE----NNMLMLPSVRPQDAGTYVCTATNRQG 3648
P P ++W K D P +R++ + L + + +D G Y T N G
Sbjct: 17246 PFPKVTWKKEDRDAPTKARIDVTPVGSKLEIRNAAHEDGGIYSLTVENPAG 17296
Score = 38.9 bits (89), Expect = 0.11
Identities = 29/94 (30%), Positives = 42/94 (44%), Gaps = 8/94 (8%)
Query: 3578 ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE-------NNMLMLPS 3630
+ V + AG A SG P P + WSK L ++LE N++ S
Sbjct: 21465 VKFKDTVILKAGEAFRLEADVSGRPPPTMEWSKDGKELEGTAKLEIKIADFSTNLVNKDS 21524
Query: 3631 VRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVP 3664
R +D+G Y TATN G K +++V +R P
Sbjct: 21525 TR-RDSGAYTLTATNPGGFAKHIFNVKVLDRPGP 21557
Score = 38.9 bits (89), Expect = 0.11
Identities = 31/101 (30%), Positives = 48/101 (47%), Gaps = 4/101 (3%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR--SERTDIATLL-IPAITTADAGFY 2023
V AG +++ G P+ +TW K+ L R +E T+ +LL I D G Y
Sbjct: 22159 VLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLTIKDACREDVGHY 22218
Query: 2024 LCVATSPAGTAQARIQVVVLSASDASPPPVKI-ESSSPSVT 2063
+ T+ AG A + V+VL PVK+ E ++ S+T
Sbjct: 22219 VVKLTNSAGEAIETLNVIVLDKPGPPTGPVKMDEVTADSIT 22259
Score = 38.9 bits (89), Expect = 0.11
Identities = 23/77 (29%), Positives = 31/77 (40%)
Query: 410 TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDV 469
T P+++I G+ V G P P +W + RVTV + L IR+
Sbjct: 29742 TMPQKTIHVPAGRPVELVIPIAGRPPPAASWFFAGSKLRESERVTVETHTKVAKLTIRET 29801
Query: 470 KESDQGAYTCEAMNARG 486
D G YT E N G
Sbjct: 29802 TIRDTGEYTLELKNVTG 29818
Score = 38.5 bits (88), Expect = 0.15
Identities = 48/200 (24%), Positives = 75/200 (37%), Gaps = 25/200 (12%)
Query: 3299 PYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVG-----SSLPGRATARNE---LL 3350
P T + V G T + G P W R G S+LPG + ++ L
Sbjct: 6 PTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWFRDGQVISTSTLPGVQISFSDGRAKL 65
Query: 3351 HFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLET 3410
+SGRY + TN G A + A+LLV+ A + P P Q T
Sbjct: 66 TIPAVTKANSGRYSLKATNGSGQATSTAELLVK-------AETAP----PNFVQRLQSMT 114
Query: 3411 KSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV------LRIQNLDQSCQGTY 3464
G+ V V ++++++G ++ Q L I GTY
Sbjct: 115 VRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGTY 174
Query: 3465 ICQAHGPWGKAQASAQLVIQ 3484
A G+A ++A+L++Q
Sbjct: 175 SVNATNSVGRATSTAELLVQ 194
Score = 38.5 bits (88), Expect = 0.15
Identities = 23/81 (28%), Positives = 32/81 (39%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P V + S G+ V +C G I W I R + + G L
Sbjct: 8345 PPVFDQHLTPVTVSEGEYVQLSCHVQGSEPIRIQWLKAGREIKPSDRCSFSFASGTAVLE 8404
Query: 466 IRDVKESDQGAYTCEAMNARG 486
+RDV ++D G Y C+A N G
Sbjct: 8405 LRDVAKADSGDYVCKASNVAG 8425
Score = 38.5 bits (88), Expect = 0.15
Identities = 28/115 (24%), Positives = 48/115 (41%), Gaps = 7/115 (6%)
Query: 3211 APQVQAEEA---ELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLE----GDTL 3263
+P +Q + + + V AG + +G P PT+ W+ LP + +E ++
Sbjct: 16521 SPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQEATIETTAISSSM 16580
Query: 3264 IIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQL 3318
+I + G Y A + AG + TII+ V P P A E+ +L
Sbjct: 16581 VIKNCQRSHQGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKL 16635
Score = 38.5 bits (88), Expect = 0.15
Identities = 171/845 (20%), Positives = 292/845 (34%), Gaps = 132/845 (15%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE--RTDIATLL-IPAITTADAGFY 2023
+ AG T+RLY G P ITW K +L + + TD T L + DAG Y
Sbjct: 19705 LRAGVTMRLYVPVKGRPPPKITWSKPNVNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKY 19764
Query: 2024 LCVATSPAGTAQARIQVVVLSASDASPPPVKIE-----------SSSPSVTEGQTLDLNC 2072
+ + G + I V VL D PPV + + P + +G + +N
Sbjct: 19765 ILTLENSCGKKEYTIVVKVL---DTPGPPVNVTVKEISKDSAYVTWEPPIIDGGSPIINY 19821
Query: 2073 VVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITV 2132
VV + +W T+ + R+ + S + EN G + T
Sbjct: 19822 VVQKRDAERKSW------STVTTECSKTSFRVANLEEGKSYFFRVFAENEYGIGDPGETR 19875
Query: 2133 SVLHGTHSGPSYTPVPGSTRPIR-IEPSSSHV------AEGQTLDLNCVVPGQAHAQVTW 2185
+ S TP P +R + SS + ++G + + VV + W
Sbjct: 19876 DAVKA-----SQTPGPVVDLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTE-ENKW 19929
Query: 2186 HKRGGSL----PARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIP 2241
+ SL A+ T G ++GE GT + + V V+
Sbjct: 19930 QRVMKSLSLQYSAKDLTEGKEYTFRVSAENENGE------GT----PSEITVVARDDVVA 19979
Query: 2242 GPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR------GSR 2295
+ + E L + G+ V+W K L +V +
Sbjct: 19980 PDLDLKGLPDLCYLAKENSNFRLKIPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTT 20039
Query: 2296 LYIFQASPADAGQYVCRASN---GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQV 2352
L ++ +DAG+Y N E +I++ V G G T PI+ + +++
Sbjct: 20040 LIVYDCQKSDAGKYTITLKNVAGTKEGTISIKVVGKPGI-------PTGPIKFDEVTAEA 20092
Query: 2353 A---------EGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSG 2403
+G + N ++ + W ++ +T + RL++
Sbjct: 20093 MTLKWAPPKDDGGSEITNYILEKRDSVNNKWVTCASAV---QKTTFRVTRLHEGM----- 20144
Query: 2404 EYVCRV-----LGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNC 2458
EY RV G L++ +V P VP P + ++ V+ T
Sbjct: 20145 EYTFRVSAENKYGVGEGLKSEPIVARHPF-DVPDAPPPPNI-VDVRHDSVSLTWTDPKKT 20202
Query: 2459 LVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSG-EYVCRV--VGSSGTQEAS 2515
+ + + +R L R R+R +VT G EY RV + +G + S
Sbjct: 20203 GGSPITGYHLEFKERNSLLWKRANKTPIRMRDFKVTGLTEGLEYEFRVMAINLAGVGKPS 20262
Query: 2516 VLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWY---KRGG 2572
+ L G + I +S +L + H +T Y KR
Sbjct: 20263 LPSEPVVALDPIDPPGKPEVINITRNSVTL-------IWTEPKYDGGHKLTGYIVEKR-- 20313
Query: 2573 SLPSRHQIVGSRLRIPQ----VTP-ADSGEYVCHV----SNGAGSRETSLIVTIQGSGSS 2623
LPS+ + + + +P+ VT + G+Y + + GA S + TI
Sbjct: 20314 DLPSKSWMKANHVNVPECAFTVTDLVEGGKYEFRIRAKNTAGAISAPSESTETIICKDEY 20373
Query: 2624 HVPSV--SPPIRIESSSPTVVEGQTLDLNCV-VARQPQAIITWYKRGGSLPSRHQTH--- 2677
P++ P I+ T+ G T+ LN + + +P +W K G + T
Sbjct: 20374 EAPTIVLDPTIK---DGLTIKAGDTIVLNAISILGKPLPKSSWSKAGKDIRPSDITQITS 20430
Query: 2678 ---GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESS 2734
S L + + D+GEY A N + ++V PG P+ I +
Sbjct: 20431 TPTSSMLTIKYATRKDAGEYTITATNPFGTKVEHVKVTVL------DVPGPPGPVEISNV 20484
Query: 2735 SSHVA 2739
S+ A
Sbjct: 20485 SAEKA 20489
Score = 38.5 bits (88), Expect = 0.15
Identities = 28/111 (25%), Positives = 46/111 (41%), Gaps = 8/111 (7%)
Query: 3578 ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE------NNMLMLPSV 3631
++ P+ + V G +A F C G P P ++W + L +R + + + SV
Sbjct: 32564 LTKPRSMTVYEGESARFSCDTDGEPVPTVTWLRKGQVLSTSARHQVTTTKYKSTFEISSV 32623
Query: 3632 RPQDAGTYVCTATNRQGKVKAFAHLQVPERVV--PYFTQTPYSFLPLPTIK 3680
+ D G Y N +GK +A L + + V T P P P +K
Sbjct: 32624 QASDEGNYSVVVENSEGKQEAEFTLTIQKARVTEKAVTSPPRVKSPEPRVK 32674
Score = 38.1 bits (87), Expect = 0.19
Identities = 19/73 (26%), Positives = 34/73 (46%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
+S+ +G V G+PTP++ + + I S ++ EG +L+I + D
Sbjct: 111 QSMTVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPED 170
Query: 474 QGAYTCEAMNARG 486
G Y+ A N+ G
Sbjct: 171 SGTYSVNATNSVG 183
Score = 38.1 bits (87), Expect = 0.19
Identities = 24/82 (29%), Positives = 32/82 (39%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP V S G++ C G P + W N + V + L
Sbjct: 3736 PPSFVKKVDPSYLMLPGESARLHCKLKGSPVIQVTWFKNNKELSESNTVRMYFVNSEAIL 3795
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
I DVK D G+Y+CEA+N G
Sbjct: 3796 DITDVKVEDSGSYSCEAVNDVG 3817
Score = 38.1 bits (87), Expect = 0.19
Identities = 27/91 (29%), Positives = 37/91 (40%), Gaps = 6/91 (6%)
Query: 402 GCMPPQVVTPPRESIQ------ASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTV 455
GCM ++ P ++ A GQTVT G + W I ++ +
Sbjct: 3913 GCMATHLLKEPPTFVKKVDDLIALGGQTVTLQAAVRGSEPISVTWMKGQEVIREDGKIKM 3972
Query: 456 TSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ G LII DV+ S G YTC A N G
Sbjct: 3973 SFSNGVAVLIIPDVQISFGGKYTCLAENEAG 4003
Score = 38.1 bits (87), Expect = 0.19
Identities = 53/212 (25%), Positives = 80/212 (37%), Gaps = 40/212 (18%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDI---ATLLIPAITTADAGFY 2023
V AG + L G P ITW K L R ++ +T+ I +D G Y
Sbjct: 13702 VKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTY 13761
Query: 2024 LCVATSPAGTAQARIQVVVLSASDASPPPVKIESS-----------SPSVTEGQTLDLNC 2072
+ A + G A A ++V VL D PP + + +P +G + N
Sbjct: 13762 IIEAVNVCGRATAVVEVNVL---DKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKITNY 13818
Query: 2073 VVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRV--ENGSG---PKE 2127
VV A W++ + V + + ++ P + EY+ RV EN G P +
Sbjct: 13819 VVERRATDSEVWHKLSST------VKDTNFKATKLIP--NKEYIFRVAAENMYGVGEPVQ 13870
Query: 2128 ASITVSVLHGTHSGPSYTPVPGSTRPIRIEPS 2159
AS + GP P R+EPS
Sbjct: 13871 ASPITAKYQFDPPGP----------PTRLEPS 13892
Score = 38.1 bits (87), Expect = 0.19
Identities = 121/576 (21%), Positives = 200/576 (34%), Gaps = 116/576 (20%)
Query: 2912 PSSPGPIPAPGLAQPIYIEASSS-----HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLP 2966
P P+ +P +E S + G+TL + VV G+ W K G L
Sbjct: 15087 PGETQPVTVAEPQEPPAVELDVSVKGGIQIMAGKTLRIPAVVTGRPVPTKVWTKEEGELD 15146
Query: 2967 ARHQTHG-----SQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRS 3021
S+L + D G YV A + G + A+ + +
Sbjct: 15147 KDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGSKFAAARVEV--------FDVPG 15198
Query: 3022 PVISIDPPSSTVQQGQDASFKCLIH------DGAAPIS---LEWKTRNQELEDNVHISPN 3072
PV+ + P + + CL++ DG + I+ +E K I
Sbjct: 15199 PVLDLKPVVTNRKM-------CLLNWSDPEDDGGSEITGFIIERKDAKMHTWRQP-IETE 15250
Query: 3073 GSIITIVGTRPSNHGTYRCVASNAYGVAQSV-----VNLSVHGPPTVSVLPEGPVWVKVG 3127
S I G +R +A N +G V + + GPPT PE + +
Sbjct: 15251 RSKCDITGLLEGQEYKFRVIAKNKFGCGPPVEIGPILAVDPLGPPTS---PERLTYTERT 15307
Query: 3128 KA-VTLECVSAGEPRSSARWTRISSTPAK---LEQRTYGLMDSHAVLQ---------ISS 3174
K+ +TL+ EPRS+ +P + +E+R + D V + + +
Sbjct: 15308 KSTITLDWK---EPRSNG------GSPIQGYIIEKRRHDKPDFERVNKRLCPTTSFLVEN 15358
Query: 3175 AKPSDAGTYVCLAQNALGTAQKQV--EVIVDTGAMAPGAP-QVQAEEAELTVEAGHTATL 3231
+ A N +G ++ + V++ + P ++ + V+AG +
Sbjct: 15359 LDEHQMYEFRVKAVNEIGESEPSLPLNVVIQDDEVPPTIKLRLSVRGDTIKVKAGEPVHI 15418
Query: 3232 RCSATGSPAPTIHWSK-----------LRSPLPWQHRLEGDT-LIIPRVAQQDSGQYICN 3279
TG P P I WSK L+ R E T L IP+ ++D G Y
Sbjct: 15419 PADVTGLPMPKIEWSKNETVIEKPTDALQITKEEVSRSEAKTELSIPKAVREDKGTYTVT 15478
Query: 3280 ATSPAGHAEATIILHVE-----SPPYATTVPEHASVQAGETVQLQCLAHGTPPLTF---- 3330
A++ G + HVE SPP V + + T L +G +T
Sbjct: 15479 ASNRLGSVFRNV--HVEVYDRPSPPRNLAVTDIKAESCYLTWDAP-LDNGGSEITHYVID 15535
Query: 3331 ---------QWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFA--Q 3379
+W V + TA + + P +R R NK G ++ +
Sbjct: 15536 KRDASRKKAEWEEVTN------TAVEKRYGIWKLIPNGQYEFRVRAVNKYGISDECKSDK 15589
Query: 3380 LLVQ------GPPGSLPATSIPAGSTPTVQVTPQLE 3409
+++Q GPPG + GS V TP L+
Sbjct: 15590 VVIQDPYRLPGPPGKPKVLARTKGSM-LVSWTPPLD 15624
Score = 38.1 bits (87), Expect = 0.19
Identities = 20/72 (27%), Positives = 29/72 (40%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
I G T G P P + W+L + RV++T+ R TL ++D D G
Sbjct: 28657 ITCKAGSPFTIDVPISGRPAPKVTWKLEEMRLKETDRVSITTTKDRTTLTVKDSMRGDSG 28716
Query: 476 AYTCEAMNARGM 487
Y N G+
Sbjct: 28717 RYFLTLENTAGV 28728
Score = 37.7 bits (86), Expect = 0.25
Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 1/83 (1%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP +E+ S G +V C G P ++W I S + T
Sbjct: 7680 VPPSFTRKLKETNGLS-GSSVVMECKVYGSPPISVSWFHEGNEISSGRKYQTTLTDNTCA 7738
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L + ++ESD G YTC A N G
Sbjct: 7739 LTVNMLEESDSGDYTCIATNMAG 7761
Score = 37.7 bits (86), Expect = 0.25
Identities = 55/263 (20%), Positives = 106/263 (40%), Gaps = 34/263 (12%)
Query: 2589 QVTPADSGEYVCH----VSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEG 2644
+VT + G++ + ++ S+ + IQ + P + +++ + TV G
Sbjct: 13647 EVTGLEEGKWYAYRVKALNRQGASKPSRPTEEIQAVDTQEAPEIFLDVKLLAGL-TVKAG 13705
Query: 2645 QTLDLNCVVARQPQAIITW------YKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRA 2698
++L V +P+ ITW K+ + + S + + +D+G Y+ A
Sbjct: 13706 TKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIEA 13765
Query: 2699 NNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA-------EGETLDLNCVVP 2751
N A + ++V G P+A I ++ S + +G + N VV
Sbjct: 13766 VNVCGRATAVVEVNVLDKPGPPAA----FDITDVTNESCLLTWNPPRDDGGSKITNYVVE 13821
Query: 2752 GQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
+A WHK ++ + + + + P + EY+ RV + V ++
Sbjct: 13822 RRATDSEVWHKLSSTV------KDTNFKATKLIP--NKEYIFRVAAEN---MYGVGEPVQ 13870
Query: 2812 ASGSSAVHVPAPGGAPPIRIEPS 2834
AS +A + P G PP R+EPS
Sbjct: 13871 ASPITAKYQFDPPG-PPTRLEPS 13892
Score = 37.7 bits (86), Expect = 0.25
Identities = 33/130 (25%), Positives = 55/130 (42%), Gaps = 4/130 (3%)
Query: 1658 VGNPSVQGGQCLPETNQAPLVVEVHP-ARSIVPQGGSHSLRCQVS--GSPPHYFYWSRED 1714
VG P+ G + + P +E+ R +V S +LR V+ G P W + +
Sbjct: 25086 VGEPATLPGSVVAQERIEPPEIELDADLRKVVVLRASATLRLFVTIKGRPEPEVKWEKAE 25145
Query: 1715 GRPVPSGT-QQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITV 1773
G + + L +V D+G Y T N S T+ + V ++PS P+ +
Sbjct: 25146 GILTDRAQIEVTSSFTMLVIDNVTRFDSGRYNLTLENNSGSKTAFVNVRVLDSPSAPVNL 25205
Query: 1774 TVEEQRSQSV 1783
T+ E + SV
Sbjct: 25206 TIREVKKDSV 25215
Score = 37.4 bits (85), Expect = 0.33
Identities = 48/190 (25%), Positives = 70/190 (36%), Gaps = 28/190 (14%)
Query: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHG---------P 2876
AP S V EG T + + G +V+W R G + + + G
Sbjct: 5 APTFTQPLQSVVVLEGSTATFEAHISGFPVPEVSWF-RDGQVISTSTLPGVQISFSDGRA 63
Query: 2877 LLRLNQVSPADSGEYSCQVTGSSG--TLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 2934
L + V+ A+SG YS + T SG T A +LV E + P + S
Sbjct: 64 KLTIPAVTKANSGRYSLKATNGSGQATSTAELLVKAETAPPNFVQ----------RLQSM 113
Query: 2935 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ------LRLHLVSPADSGE 2988
V +G + L V G V +Y+ G + + SQ L + P DSG
Sbjct: 114 TVRQGSQVRLQVRVTGIPTPVVKFYRDGAEIQSSLDFQISQEGDLYSLLIAEAYPEDSGT 173
Query: 2989 YVCRAASGPG 2998
Y A + G
Sbjct: 174 YSVNATNSVG 183
Score = 37.4 bits (85), Expect = 0.33
Identities = 23/83 (27%), Positives = 36/83 (43%), Gaps = 1/83 (1%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PPQV+ + + G+ F V G P P I+W + + + +G TL
Sbjct: 3238 PPQVLQE-LQPVTVQSGKPARFCAVISGRPQPKISWYKEEQLLSTGFKCKFLHDGQEYTL 3296
Query: 465 IIRDVKESDQGAYTCEAMNARGM 487
++ + D YTCEA N G+
Sbjct: 3297 LLIEAFPEDAAVYTCEAKNDYGV 3319
Score = 37.4 bits (85), Expect = 0.33
Identities = 22/83 (26%), Positives = 33/83 (39%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+ P + ESI+ + G T T C G P W + + S + ++
Sbjct: 7583 LEPATIVEKPESIKVTTGDTCTLECTVAGTPELSTKWFKDGKELTSDNKYKISFFNKVSG 7642
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
L I +V SD G Y+ E N G
Sbjct: 7643 LKIINVAPSDSGVYSFEVQNPVG 7665
Score = 37.4 bits (85), Expect = 0.33
Identities = 22/97 (22%), Positives = 39/97 (40%), Gaps = 2/97 (2%)
Query: 390 EESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPS 449
E +D + D Q+ R+ I G + G P P + W +N +P
Sbjct: 16508 EVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGKPPPTVTWNMNERTLPQ 16567
Query: 450 HPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ T+ +++I++ + S QG Y+ A N G
Sbjct: 16568 EATIETTAIS--SSMVIKNCQRSHQGVYSLLAKNEAG 16602
Score = 37.4 bits (85), Expect = 0.33
Identities = 92/429 (21%), Positives = 146/429 (34%), Gaps = 75/429 (17%)
Query: 2139 HSGPSYTPVPGSTRPIRIEPSSSHVAE---------GQTLDLNCVVPGQAHAQVTWHKRG 2189
+S PS P + I I P A+ G T+ L V G+ ++TW K
Sbjct: 19672 YSDPSDVPDKHYPKDILIPPEGELDADLRKTLILRAGVTMRLYVPVKGRPPPKITWSKPN 19731
Query: 2190 GSLPAR------HQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGP 2243
+L R + LR V D+G+Y+ + + G E +++V V+ P
Sbjct: 19732 VNLRDRIGLDIKSTDFDTFLRCENVNKYDAGKYILTLENSCGKKEYTIVV----KVLDTP 19787
Query: 2244 IPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYK---RGGSLPARH--QVRGSRLYI 2298
PPV + TV E + A VTW GGS + Q R +
Sbjct: 19788 GPPVNV-----TVKE----------ISKDSAYVTWEPPIIDGGSPIINYVVQKRDAERKS 19832
Query: 2299 FQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTL 2358
+ + + R +N E + A Y G R +SQ G +
Sbjct: 19833 WSTVTTECSKTSFRVANLEEGK---SYFFRVFAENEYGIGDPGETRDAVKASQ-TPGPVV 19888
Query: 2359 DLNCVVPGQSHAQVTW---HKRGGSLPVRH------------QTHGSLLRLYQASPADSG 2403
DL +S + W H GGS + + + SL Y A G
Sbjct: 19889 DLKVRSVSKSSCSIGWKKPHSDGGSRIIGYVVDFLTEENKWQRVMKSLSLQYSAKDLTEG 19948
Query: 2404 -EYVCRVL-----GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLN 2457
EY RV G P E +V+ + L P + E L
Sbjct: 19949 KEYTFRVSAENENGEGTPSEITVVARDDVVAPDLDLKGLPDL-----CYLAKENSNFRLK 20003
Query: 2458 CLVAGQAHAQVTWHKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSSGT 2511
+ G+ V+W K L +V + L + +D+G+Y + +GT
Sbjct: 20004 IPIKGKPAPSVSWKKGEDPLATDTRVSVESSAVNTTLIVYDCQKSDAGKYTITLKNVAGT 20063
Query: 2512 QEASVLVTI 2520
+E ++ + +
Sbjct: 20064 KEGTISIKV 20072
Score = 37.0 bits (84), Expect = 0.43
Identities = 21/82 (25%), Positives = 33/82 (40%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP+ V S A +G+++ C G P ++W N + + ++ L
Sbjct: 6363 PPKFVKKLEASKVAKQGESIQLECKISGSPEIKVSWFRNDSELHESWKYNMSFINSVALL 6422
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
I + D G Y CEA N G
Sbjct: 6423 TINEASAEDSGDYICEAHNGVG 6444
Score = 37.0 bits (84), Expect = 0.43
Identities = 22/84 (26%), Positives = 36/84 (42%), Gaps = 2/84 (2%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G + G P P I W + R+T+ + + T+ I D K SD G Y E
Sbjct: 13705 GTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTGTYIIE 13764
Query: 481 AMNARGMVFGIPDGVLELVPQRGP 504
A+N G + + + ++ + GP
Sbjct: 13765 AVNVCGRATAVVE--VNVLDKPGP 13786
Score = 36.6 bits (83), Expect = 0.56
Identities = 26/82 (31%), Positives = 34/82 (41%), Gaps = 2/82 (2%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
P +V P R+ QA TV F + G P I W + + S P+ + EG L
Sbjct: 5330 PSFLVKPGRQ--QAIPDSTVEFKAILKGTPPFKIKWFKDDVELVSGPKCFIGLEGSTSFL 5387
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
+ V S G YTC N G
Sbjct: 5388 NLYSVDASKTGQYTCHVTNDVG 5409
Score = 36.6 bits (83), Expect = 0.56
Identities = 82/419 (19%), Positives = 148/419 (35%), Gaps = 62/419 (14%)
Query: 3140 PRSSARWTRISSTPAK---LEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK 3196
P + +W R++S P K + + D VL++ A NA+G ++
Sbjct: 14325 PVGTEKWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVR-------------AVNAIGVSEP 14371
Query: 3197 QVEVIVDTGAMAPGA-PQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQ 3255
E+ + A P P + E ++ V G ++ P PT+ W K +
Sbjct: 14372 S-EISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKAS 14430
Query: 3256 HRLEGDT------LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHAS 3309
RL L +P+ + D+G Y + G A A+I + V P
Sbjct: 14431 DRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATASINVKVIGLPGPC-----KD 14485
Query: 3310 VQAGETVQLQC--------LAHGTPPLTFQWSRVGSS----LPGRATARNELLHFERAAP 3357
++A + + C GTP L + R + +P + + P
Sbjct: 14486 IKASDITKSSCKLTWEPPEFDGGTPILHYVLERREAGRRTYIPVMSGENKLSWTVKDLIP 14545
Query: 3358 EDSGRYRCRVTNKVGSAEAFA---QLLVQGP--PGSLPA---TSIPAGSTPTVQVTPQLE 3409
+R + NKVG E ++ Q P P P P T+ P L
Sbjct: 14546 NGEYFFRVKAVNKVGGGEYIELKNPVIAQDPKQPPDPPVDVEVHNPTAEAMTITWKPPLY 14605
Query: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAH 3469
G+ + + +G + RW + L P + + L++ + + +A
Sbjct: 14606 DG--GSKIMGYIIEKIAKGEE-RWKRCNEHLVPILT-----YTAKGLEEGKEYQFRVRAE 14657
Query: 3470 GPWGKAQASAQL----VIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK 3524
G ++ S + + + + +RTS++ V G + + G P P +TW K
Sbjct: 14658 NAAGISEPSRATPPTKAVDPIDAPKVILRTSLE-VKRGDEIALDASISGSPYPTITWIK 14715
Score = 36.6 bits (83), Expect = 0.56
Identities = 163/881 (18%), Positives = 285/881 (32%), Gaps = 137/881 (15%)
Query: 2594 DSGEYVCHVS--NGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2651
+ GEY V N AG + S V G P + P I ++ V EG +++
Sbjct: 16083 EGGEYEFRVKAVNAAGVSKPSATV---GPCDCQRPDMPPSIDLKEFME-VEEGTNVNIVA 16138
Query: 2652 VVARQPQAIITWYKRGGSLPSR-----HQTHGSHLRLH--------QMSVADSGEYVCRA 2698
+ P +TW+K P + TH + L + Q +D+G Y A
Sbjct: 16139 KIKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITA 16198
Query: 2699 NNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA---------EGETLDLNCV 2749
NN+ + ++V G P PI+ ES S+ +G + N V
Sbjct: 16199 VNNLGTASKEMRLNVLGRPGPPVG-----PIKFESVSADQMTLSWFPPKDDGGSKITNYV 16253
Query: 2750 VPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVT 2809
+ + + TW T L H EYV R+M + L +
Sbjct: 16254 IEKREANRKTWVHVSSEPKECTYTIPKLLEGH--------EYVFRIMAQNKYGIGEPLDS 16305
Query: 2810 IEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAH-------AQVTWHK 2862
+ + VP P + +S + + P + W K
Sbjct: 16306 EPETARNLFSVPGAPDKPTVSSVTRNSMTVNWEEPEYDGGSPVTGYWLEMKDTTSKRW-K 16364
Query: 2863 RGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPG----PI 2918
R P + G ++ + ++ ++G AS+ PS P PI
Sbjct: 16365 RVNRDPIKAMTLGVSYKVTGLIEGSDYQFRVYAINAAGVGPASL-----PSDPATARDPI 16419
Query: 2919 PAPGLAQPIYIEASSSH--------VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQ 2970
PG P + + S + +G + +V + + W K +
Sbjct: 16420 APPGPPFPKVTDWTKSSADLEWSPPLKDGGSKVTGYIVEYKEEGKEEWEKGKDK-----E 16474
Query: 2971 THGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDP-- 3028
G++L + + ++ RA + G + T + + RL SP + +D
Sbjct: 16475 VRGTKLVVTGLKEGAFYKFRVRAVNIAGIGEPGEVTDVIEMKD----RLVSPDLQLDASV 16530
Query: 3029 -PSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNGSIITIVGTRPSN 3085
V G + G P ++ W + L E + + S + I + S+
Sbjct: 16531 RDRIVVHAGGVIRIIAYV-SGKPPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSH 16589
Query: 3086 HGTYRCVASNAYGVAQSVV---NLSVHGPPTVSVLPEG-------PVWVKV----GKAVT 3131
G Y +A N G + + L V GP L W G +T
Sbjct: 16590 QGVYSLLAKNEAGERKKTIIVDVLDVPGPVGTPFLAHNLTNESCKLTWFSPEDDGGSPIT 16649
Query: 3132 LECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNAL 3191
+ E A WT ++ T + GL+ A + A+N++
Sbjct: 16650 NYVIEKRESDRRA-WTPVTYTVTRQNATVQGLIQGKAYF------------FRIAAENSI 16696
Query: 3192 GT---AQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT----GSPAPTIH 3244
G + +++ P P E+ E+ +T TL + GS
Sbjct: 16697 GMGPFVETSEALVIREPITVPERP----EDLEVKEVTKNTVTLTWNPPKYDGGSEIINYV 16752
Query: 3245 WSKLRSPLPWQHRLEGDTLI-----IPRVAQQDSGQYICNATSPAGHAEATIIL------ 3293
H++ D L+ + + + D+ +Y +A + G + +
Sbjct: 16753 LESRLIGTEKFHKVTNDNLLSRKYTVKGLKEGDTYEYRVSAVNIVGQGKPSFCTKPITCK 16812
Query: 3294 -HVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPG------RATAR 3346
+ P + +++ GE L G P W + + + + T
Sbjct: 16813 DELAPPTLHLDFRDKLTIRVGEAFALTGRYSGKPKPKVSWFKDEADVLEDDRTHIKTTPA 16872
Query: 3347 NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG 3387
L +A DSG+Y V N GS + F Q+ V PG
Sbjct: 16873 TLALEKIKAKRSDSGKYCVVVENSTGSRKGFCQVNVVDRPG 16913
Score = 36.6 bits (83), Expect = 0.56
Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 2/66 (3%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCE 480
G T+ + + GVP P + W+ P+ R+ VT G + L IR+ D G Y+
Sbjct: 17233 GDTLRLSAIIKGVPFPKVTWKKEDRDAPTKARIDVTPVGSK--LEIRNAAHEDGGIYSLT 17290
Query: 481 AMNARG 486
N G
Sbjct: 17291 VENPAG 17296
Score = 36.6 bits (83), Expect = 0.56
Identities = 33/123 (26%), Positives = 46/123 (37%), Gaps = 12/123 (9%)
Query: 3298 PPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLP------GRATARNELLH 3351
PP + +V AGE +++ G P W + L +T N LL
Sbjct: 22147 PPAFKLLFNTFTVLAGEDLKVDVPFIGRPTPAVTWHKDNVPLKQTTRVNAESTENNSLLT 22206
Query: 3352 FERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETK 3411
+ A ED G Y ++TN G A ++V PG P G +VT T
Sbjct: 22207 IKDACREDVGHYVVKLTNSAGEAIETLNVIVLDKPGP------PTGPVKMDEVTADSITL 22260
Query: 3412 SIG 3414
S G
Sbjct: 22261 SWG 22263
Score = 36.6 bits (83), Expect = 0.56
Identities = 21/71 (29%), Positives = 29/71 (40%), Gaps = 1/71 (1%)
Query: 417 QASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG-GRGTLIIRDVKESDQG 475
+ GQ+V F G+P P + W + + P + + EG L IRD D G
Sbjct: 31805 ECQEGQSVCFEIRVSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTG 31864
Query: 476 AYTCEAMNARG 486
Y A N G
Sbjct: 31865 YYRVTATNTAG 31875
Score = 36.2 bits (82), Expect = 0.74
Identities = 23/97 (23%), Positives = 39/97 (40%), Gaps = 6/97 (6%)
Query: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2967
VT P P+ P + + V EG+++ L C + G VTWY+ + +
Sbjct: 926 VTETARVPAPVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGYPSPTVTWYREDYQIES 985
Query: 2968 ------RHQTHGSQLRLHLVSPADSGEYVCRAASGPG 2998
Q+ ++L + DSG + C A + G
Sbjct: 986 SIDFQITFQSGIARLMIREAFAEDSGRFTCSAVNEAG 1022
Score = 36.2 bits (82), Expect = 0.74
Identities = 24/67 (35%), Positives = 30/67 (44%), Gaps = 1/67 (1%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTS-EGGRGTLIIRDVKESDQGAYTC 479
G VTF C G P P I W + I R + + GR +L I V D+G YT
Sbjct: 1305 GMGVTFHCKMSGYPLPKIAWYKDGKRIKHGERYQMDFLQDGRASLRIPVVLPEDEGIYTA 1364
Query: 480 EAMNARG 486
A N +G
Sbjct: 1365 FASNIKG 1371
Score = 36.2 bits (82), Expect = 0.74
Identities = 19/82 (23%), Positives = 36/82 (43%), Gaps = 1/82 (1%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP ++ P+ S+ G+ F C G P W+ + + P ++ + L
Sbjct: 3550 PPTFLSRPK-SLTTFVGKAAKFICTVTGTPVIETIWQKDGAALSPSPNWRISDAENKHIL 3608
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
+ ++ D+G Y+C+A N G
Sbjct: 3609 ELSNLTIQDRGVYSCKASNKFG 3630
Score = 36.2 bits (82), Expect = 0.74
Identities = 33/140 (23%), Positives = 49/140 (35%), Gaps = 21/140 (15%)
Query: 3546 ELADAGQY--RCTATNAAGTTQSHVLL------LVQALPQISMPQEVRVPAGSAAVFPCI 3597
+L + G+Y R A NAAG ++ + P I + + + V G+
Sbjct: 16080 DLVEGGEYEFRVKAVNAAGVSKPSATVGPCDCQRPDMPPSIDLKEFMEVEEGTNVNIVAK 16139
Query: 3598 ASGYPTPDISWSKLDGSLPPDSRL-------------ENNMLMLPSVRPQDAGTYVCTAT 3644
G P P ++W K P + + L++P R D G Y TA
Sbjct: 16140 IKGVPFPTLTWFKAPPKKPDNKEPVLYDTHVNKLVVDDTCTLVIPQSRRSDTGLYTITAV 16199
Query: 3645 NRQGKVKAFAHLQVPERVVP 3664
N G L V R P
Sbjct: 16200 NNLGTASKEMRLNVLGRPGP 16219
Score = 35.8 bits (81), Expect = 0.96
Identities = 22/81 (27%), Positives = 36/81 (44%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P V T + A +G V C G P + W + + + + +TS+ +L
Sbjct: 6457 PPVFTQKPSPVGALKGSDVILQCEISGTPPFEVVWVKDRKQVRNSKKFKITSKHFDTSLH 6516
Query: 466 IRDVKESDQGAYTCEAMNARG 486
I +++ SD G Y C+A N G
Sbjct: 6517 ILNLEASDVGEYHCKATNEVG 6537
Score = 35.8 bits (81), Expect = 0.96
Identities = 21/64 (32%), Positives = 29/64 (45%), Gaps = 1/64 (1%)
Query: 412 PRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKE 471
P + + + G+T TF C P+ W L + +V SEG TL +RDVK
Sbjct: 12201 PLKDVTVTAGETATFDCELSYEDIPV-EWYLKGKKLEPSDKVVPRSEGKVHTLTLRDVKL 12259
Query: 472 SDQG 475
D G
Sbjct: 12260 EDAG 12263
Score = 35.8 bits (81), Expect = 0.96
Identities = 100/442 (22%), Positives = 155/442 (35%), Gaps = 53/442 (11%)
Query: 2844 LDLKCVVPGQAHAQVTW---HKRGGN-LPARHQVHGPL-----LRLNQVSPADSGEYSCQ 2894
LDL G+ H + W K GG+ + H P+ +R+N P ++ +
Sbjct: 14289 LDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNS-RPIKDLKFKVE 14347
Query: 2895 ---VTGSSGTLEASVLVTIEPSSPGPIPA------PGLAQPIYIEASSSHVTEGQTLDLN 2945
V L + I S P I P I +E V EG+ L +
Sbjct: 14348 EGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTIDLETHDIIVIEGEKLSIP 14407
Query: 2946 CVVPGQAHAQVTWYKRGGSLPA--RHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEA 3003
V+W+K G + A R + HL P RA +G
Sbjct: 14408 VPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKS-----VRADAG------- 14455
Query: 3004 SFTVTVPPSEGSSYR-LRSPVISIDPPSSTVQQGQDASFKCLI------HDGAAPIS--- 3053
+T+T+ GS+ + VI + P ++ C + DG PI
Sbjct: 14456 IYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFDGGTPILHYV 14515
Query: 3054 LEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPT 3113
LE + + V N T+ P+ +R A N G + + +
Sbjct: 14516 LERREAGRRTYIPVMSGENKLSWTVKDLIPNGEYFFRVKAVNKVGGGEYIELKNPVIAQD 14575
Query: 3114 VSVLPEGPVWVKV----GKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAV 3169
P+ PV V+V +A+T+ S I AK E+R +
Sbjct: 14576 PKQPPDPPVDVEVHNPTAEAMTITWKPPLYDGGSKIMGYIIEKIAKGEERWKRCNEHLVP 14635
Query: 3170 LQISSAKPSDAGT---YVCLAQNALGTAQKQVEVIVDTGAMAP-GAPQVQAEEAELTVEA 3225
+ +AK + G + A+NA G ++ T A+ P AP+V + L V+
Sbjct: 14636 ILTYTAKGLEEGKEYQFRVRAENAAGISEPS-RATPPTKAVDPIDAPKVILRTS-LEVKR 14693
Query: 3226 GHTATLRCSATGSPAPTIHWSK 3247
G L S +GSP PTI W K
Sbjct: 14694 GDEIALDASISGSPYPTITWIK 14715
Score = 35.8 bits (81), Expect = 0.96
Identities = 27/80 (33%), Positives = 40/80 (50%), Gaps = 6/80 (7%)
Query: 1966 QVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT---LLIPAITTADAGF 2022
Q+ AG+T+R+ G P T W KE G L + R ++ T L+I D G
Sbjct: 15115 QIMAGKTLRIPAVVTGRPVPTKVWTKEEGEL-DKDRVVIDNVGTKSELIIKDALRKDHGR 15173
Query: 2023 YLCVATSPAGT--AQARIQV 2040
Y+ AT+ G+ A AR++V
Sbjct: 15174 YVITATNSCGSKFAAARVEV 15193
Score = 35.8 bits (81), Expect = 0.96
Identities = 40/165 (24%), Positives = 63/165 (38%), Gaps = 23/165 (13%)
Query: 3549 DAGQYRCTATNAAGTTQ-SHVLLLVQALPQISMP-------QEVRVPAGSAAVFPCIASG 3600
D +YR +A N G + S + +++ P ++ + G A SG
Sbjct: 16785 DTYEYRVSAVNIVGQGKPSFCTKPITCKDELAPPTLHLDFRDKLTIRVGEAFALTGRYSG 16844
Query: 3601 YPTPDISWSKLDGSLPPDSRLENN----MLMLPSVRPQ--DAGTYVCTATNRQGKVKAFA 3654
P P +SW K + + D R L L ++ + D+G Y N G K F
Sbjct: 16845 KPKPKVSWFKDEADVLEDDRTHIKTTPATLALEKIKAKRSDSGKYCVVVENSTGSRKGFC 16904
Query: 3655 HLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADG 3699
+ V +R P P SF D K + I+++P DG
Sbjct: 16905 QVNVVDRPGP--PVGPVSF-------DEVTKDYMVISWKPPLDDG 16940
Score = 35.8 bits (81), Expect = 0.96
Identities = 22/79 (27%), Positives = 33/79 (41%), Gaps = 6/79 (7%)
Query: 3586 VPAGSAAVFPCIASGYPTPDISWS------KLDGSLPPDSRLENNMLMLPSVRPQDAGTY 3639
V AG+ FP I G P P W+ K D ++ +++L + + +D G Y
Sbjct: 17522 VKAGTTVRFPAIIRGVPVPTAKWTTDGSEIKTDEHYTVETDNFSSVLTIKNCLRRDTGEY 17581
Query: 3640 VCTATNRQGKVKAFAHLQV 3658
T +N G HL V
Sbjct: 17582 QITVSNAAGSKTVAVHLTV 17600
Score = 35.8 bits (81), Expect = 0.96
Identities = 22/83 (26%), Positives = 33/83 (39%), Gaps = 2/83 (2%)
Query: 406 PQVVTPP--RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
P++ P R++I + G+T G P P I W I R + + +
Sbjct: 23623 PRISMDPKFRDTIVVNAGETFRLEADVHGKPLPTIEWLRGDKEIEESARCEIKNTDFKAL 23682
Query: 464 LIIRDVKESDQGAYTCEAMNARG 486
LI++D D G Y A N G
Sbjct: 23683 LIVKDAIRIDGGQYILRASNVAG 23705
Score = 35.8 bits (81), Expect = 0.96
Identities = 27/114 (23%), Positives = 47/114 (41%), Gaps = 8/114 (7%)
Query: 3590 SAAVFPCIASGYPTPDISWSKLDGSLPPDS---RLEN-----NMLMLPSVRPQDAGTYVC 3641
S A C +G+P P + W + + D R++ + L++ SV DA Y
Sbjct: 30943 SNATLVCKVTGHPKPIVKWYRQGKEIIADGLKYRIQEFKGGYHQLIIASVTDDDATVYQV 31002
Query: 3642 TATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPD 3695
ATN+ G V A L+V + +T + ++ +I + +PD
Sbjct: 31003 RATNQGGSVSGTASLEVEVPAKIHLPKTLEGMGAVHALRGEVVSIKIPFSGKPD 31056
Score = 35.4 bits (80), Expect = 1.3
Identities = 84/390 (21%), Positives = 132/390 (33%), Gaps = 47/390 (12%)
Query: 2163 VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGS----LLRLHQVTPADSGEYVC 2218
V G + + G+ V W K L R + L + DSG+Y
Sbjct: 26198 VKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSRTSLTIENANRNDSGKYTL 26257
Query: 2219 HVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTW 2278
+ L A+ L T+ V+ P PP I T E L V A V
Sbjct: 26258 TIQNV---LSAASL-TLVVKVLDTPGPPTNITVQDVT-KESAVLSWD-VPENDGGAPVKN 26311
Query: 2279 Y---KRGGSLPARHQVRGS--RLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANL 2333
Y KR S A V + RL + + Y R S E + + +G +
Sbjct: 26312 YHIEKREASKKAWVSVTNNCNRLSYKVTNLQEGAIYYFRVSGENEFGVGIPAETKEGVKI 26371
Query: 2334 AYPAGSTQPIRIEPSSSQVA---------EGQTLDLNCVVPGQSHAQVTWHKRGGSLPVR 2384
+ + + S +G + ++ VV Q W K +
Sbjct: 26372 TEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYVVEALEKGQKNWVKCAVAKSTH 26431
Query: 2385 HQTHGSLLRLYQASPADSGEYVCRVL-----GSSVPLEASVLVTIEPAGSVPALGVTPTV 2439
H G LR ++ EY RV G S P E + V I+ P + +
Sbjct: 26432 HVVSG--LR-------ENSEYFFRVFAENQAGLSDPRELLLPVLIKEQLEPPEIDMK--- 26479
Query: 2440 RIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGS------RLRLLQV 2493
S + V G L ++ ++G+ +VT + G L A + + + L +
Sbjct: 26480 NFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPLKATMRFNTEITAENLTINLKES 26539
Query: 2494 TPADSGEYVCRVVGSSGTQEASVLVTIQQR 2523
AD+G Y SSGT +A + + + R
Sbjct: 26540 VTADAGRYEITAANSSGTTKAFINIVVLDR 26569
Score = 35.0 bits (79), Expect = 1.6
Identities = 21/95 (22%), Positives = 36/95 (37%)
Query: 392 SDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHP 451
S C R + + P T + + + +G + C+ G I W + I +
Sbjct: 4660 SSCKARINVLDLIIPPSFTKKLKKMDSIKGSFIDLECIVAGSHPISIQWFKDDQEISASE 4719
Query: 452 RVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ + L I ++ +D G YTC A N G
Sbjct: 4720 KYKFSFHDNTAFLEISQLEGTDSGTYTCSATNKAG 4754
Score = 35.0 bits (79), Expect = 1.6
Identities = 22/67 (32%), Positives = 27/67 (40%), Gaps = 1/67 (1%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
+ + GQT T TC VP W N + R E L I DV+ D
Sbjct: 8752 QDVTLKEGQTCTMTC-QFSVPNVKSEWFRNGRILKPQGRHKTEVEHKVHKLTIADVRAED 8810
Query: 474 QGAYTCE 480
QG YTC+
Sbjct: 8811 QGQYTCK 8817
Score = 35.0 bits (79), Expect = 1.6
Identities = 65/280 (23%), Positives = 103/280 (36%), Gaps = 42/280 (15%)
Query: 1989 WRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDA 2048
W K G + P TD+ I + F + A + AG +LS D
Sbjct: 14230 WVKAGKTAGPDCNFRVTDV-------IEGTEVQFQVR-AENEAGVGHPSEPTEILSIEDP 14281
Query: 2049 SPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTW---YRRGGS--LPPHTQV-HGSRL 2102
+ PP SP LDL+ AG H + W + GGS + H ++
Sbjct: 14282 TSPP------SPP------LDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTE 14329
Query: 2103 RLPQVSPADSGEYVCRVENGSGP-KEASITVSVLHGTH-SGPS------YTPVPGSTRPI 2154
+ +V+ + +VE G P KE + V ++ S PS P I
Sbjct: 14330 KWMRVNSRPIKDLKFKVEEGVVPDKEYVLRVRAVNAIGVSEPSEISENVVAKDPDCKPTI 14389
Query: 2155 RIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA------RHQTHGSLLRLHQV 2208
+E V EG+ L + V+WHK G + A ++ + L + +
Sbjct: 14390 DLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKS 14449
Query: 2209 TPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVR 2248
AD+G Y + G AS+ V + +PGP ++
Sbjct: 14450 VRADAGIYTITLENKLGSATASINVKVIG--LPGPCKDIK 14487
Score = 35.0 bits (79), Expect = 1.6
Identities = 36/130 (27%), Positives = 53/130 (40%), Gaps = 17/130 (13%)
Query: 2215 EYVCHV-----VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVA 2269
EYV V +G S P E S V + P P + +E+ V EG+ L +
Sbjct: 14355 EYVLRVRAVNAIGVSEPSEISENVVAKD---PDCKPTIDLETHDIIVIEGEKLSIPVPFR 14411
Query: 2270 GQAHAQVTWYKRGGSLPARHQVR------GSRLYIFQASPADAGQYVCRASNGM---EAS 2320
V+W+K G + A ++ + L + ++ ADAG Y N + AS
Sbjct: 14412 AVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENKLGSATAS 14471
Query: 2321 ITVTVTGTQG 2330
I V V G G
Sbjct: 14472 INVKVIGLPG 14481
Score = 35.0 bits (79), Expect = 1.6
Identities = 30/122 (24%), Positives = 45/122 (36%), Gaps = 12/122 (9%)
Query: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD---IATLLI 2012
P + + V G + + VP T++W K+G + R + A L +
Sbjct: 14387 PTIDLETHDIIVIEGEKLSIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEV 14446
Query: 2013 PAITTADAGFYLCVATSPAGTAQARIQVVV---------LSASDASPPPVKIESSSPSVT 2063
P ADAG Y + G+A A I V V + ASD + K+ P
Sbjct: 14447 PKSVRADAGIYTITLENKLGSATASINVKVIGLPGPCKDIKASDITKSSCKLTWEPPEFD 14506
Query: 2064 EG 2065
G
Sbjct: 14507 GG 14508
Score = 35.0 bits (79), Expect = 1.6
Identities = 33/129 (25%), Positives = 51/129 (39%), Gaps = 19/129 (14%)
Query: 2042 VLSASDASPPPVKIESSSP-SVTEGQTLDLNCVVAGSAHAQVTWYR--------RGGSLP 2092
V+ D P + ++ S +V G T+ L V G +V W + R +
Sbjct: 18192 VVVKEDLQKPVLDLKLSGVLTVKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVK 18251
Query: 2093 PHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTR 2152
T+ S+ L + +D G+YV N +G A TV+VL PG R
Sbjct: 18252 IDTRADSSKFSLTKAKRSDGGKYVVTATNTAGSFVAYATVNVL----------DKPGPVR 18301
Query: 2153 PIRIEPSSS 2161
++I SS
Sbjct: 18302 NLKIVDVSS 18310
Score = 35.0 bits (79), Expect = 1.6
Identities = 24/79 (30%), Positives = 37/79 (46%), Gaps = 4/79 (5%)
Query: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSR----LRLPQVSPADSGEYV 2116
++ G +L L + G +V W + G + + + L L V+ DSG+Y
Sbjct: 22953 NIRAGGSLRLFVPIKGRPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYT 23012
Query: 2117 CRVENGSGPKEASITVSVL 2135
+EN SG K A +TV VL
Sbjct: 23013 LTLENSSGTKSAFVTVRVL 23031
Score = 35.0 bits (79), Expect = 1.6
Identities = 21/84 (25%), Positives = 32/84 (38%), Gaps = 2/84 (2%)
Query: 405 PPQVVTPP--RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
PP+V+ R+ I G+ + G P P+I+W + I R + S
Sbjct: 25786 PPRVMMDVKFRDVIVVKAGEVLKINADIAGRPLPVISWAKDGIEIEERARTEIISTDNHT 25845
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
L ++D D G Y N G
Sbjct: 25846 LLTVKDCIRRDTGQYVLTLKNVAG 25869
Score = 34.7 bits (78), Expect = 2.1
Identities = 13/34 (38%), Positives = 19/34 (55%)
Query: 1866 PVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW 1899
P + ++P + V G+ A FRC TG P P + W
Sbjct: 1841 PDIVLYPEPVRVLEGETARFRCRVTGYPQPKVNW 1874
Score = 34.7 bits (78), Expect = 2.1
Identities = 33/134 (24%), Positives = 50/134 (37%), Gaps = 8/134 (5%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PP + ++ + A G +V C G + W + I S P+ + T
Sbjct: 6739 VPPSFIRKLKD-VNAILGASVVLECRVSGSAPISVGWFQDGNEIVSGPKCQSSFSENVCT 6797
Query: 464 LIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPCFC 523
L + ++ SD G YTC A N G ++ P PD S LP
Sbjct: 6798 LNLSLLEPSDTGIYTCVAANVAGSDECSAVLTVQEPPSFEQTPD-------SVEVLPGMS 6850
Query: 524 FGITSVCQSTRRFR 537
TSV + T F+
Sbjct: 6851 LTFTSVIRGTPPFK 6864
Score = 34.7 bits (78), Expect = 2.1
Identities = 21/72 (29%), Positives = 29/72 (40%)
Query: 415 SIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQ 474
S+ + G++ TF C G I W + I +T TL + V + D
Sbjct: 7220 SVDLALGESGTFKCHVTGTAPIKITWAKDNREIRPGGNYKMTLVENTATLTVLKVGKGDA 7279
Query: 475 GAYTCEAMNARG 486
G YTC A N G
Sbjct: 7280 GQYTCYASNIAG 7291
Score = 34.7 bits (78), Expect = 2.1
Identities = 80/392 (20%), Positives = 133/392 (33%), Gaps = 73/392 (18%)
Query: 3032 TVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS----PNGSIITIVGTRPSNHG 3087
TV+ G + P + W + L+ + I+ P S +TIV ++ S+ G
Sbjct: 13701 TVKAGTKIELPATVTGKPEP-KITWTKADMILKQDKRITIENVPKKSTVTIVDSKRSDTG 13759
Query: 3088 TYRCVASNAYGVAQSVVNLSV---HGPPTV----------SVLPEGPVWVKVGKAVTLEC 3134
TY A N G A +VV ++V GPP +L P G +T
Sbjct: 13760 TYIIEAVNVCGRATAVVEVNVLDKPGPPAAFDITDVTNESCLLTWNPPRDDGGSKIT-NY 13818
Query: 3135 VSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTA 3194
V S W ++SST + L+ P+ + A+N G
Sbjct: 13819 VVERRATDSEVWHKLSSTVKDTNFKATKLI------------PNKEYIFRVAAENMYGVG 13866
Query: 3195 QK-QVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSP-- 3251
+ Q I P P + E +++T +A G T +W + P
Sbjct: 13867 EPVQASPITAKYQFDPPGPPTRLEPSDITKDAVTLTWCEPDDDGGSPITGYWVERLDPDT 13926
Query: 3252 --------LPWQ---HRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3300
+P + +R++G T + + + + P+ E +I PP+
Sbjct: 13927 DKWVRCNKMPVKDTTYRVKGLT-NKKKYRFRVLAENLAGPGKPSKSTEPILIKDPIDPPW 13985
Query: 3301 AT-----------------TVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA 3343
T PEH E+ ++ L GT +W RV +P
Sbjct: 13986 PPGKPTVKDVGKTSVRLNWTKPEHDGGAKIESYVIEMLKTGTD----EWVRVAEGVPTTQ 14041
Query: 3344 TARNELLHFERAAPEDSGRYRCRVTNKVGSAE 3375
L+ + + +R R NK G +E
Sbjct: 14042 HLLPGLMEGQEYS------FRVRAVNKAGESE 14067
Score = 34.7 bits (78), Expect = 2.1
Identities = 27/93 (29%), Positives = 38/93 (40%), Gaps = 9/93 (9%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGSL-----PPQARSERTDIATLLIPAITTADAG 2021
V AG T+RL G P + W K+ + P R D + + +D G
Sbjct: 18213 VKAGDTIRLEAGVRGKPFPEVAWTKDKDATDLTRSPRVKIDTRADSSKFSLTKAKRSDGG 18272
Query: 2022 FYLCVATSPAGTAQARIQVVVLSASDASPPPVK 2054
Y+ AT+ AG+ A V VL P PV+
Sbjct: 18273 KYVVTATNTAGSFVAYATVNVLD----KPGPVR 18301
Score = 34.7 bits (78), Expect = 2.1
Identities = 33/126 (26%), Positives = 46/126 (36%), Gaps = 8/126 (6%)
Query: 2027 ATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYR 2086
A + G + R V A + PP + ++ G+ L + V G H W +
Sbjct: 18875 ARNAVGVSLPREAEGVYEAKEQLLPPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKK 18934
Query: 2087 RGGSL--PPHTQVH----GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHS 2140
+ H VH S L + V+ DSG Y EN SG I V V+
Sbjct: 18935 GEDEVVTSSHLAVHKADSSSILIIKDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDA--P 18992
Query: 2141 GPSYTP 2146
GP P
Sbjct: 18993 GPPQPP 18998
Score = 34.7 bits (78), Expect = 2.1
Identities = 52/255 (20%), Positives = 93/255 (36%), Gaps = 38/255 (14%)
Query: 2012 IPAITTADAGFYLCVATSPAGTAQARIQVV--VLSASDASPPPVKIES----SSPSVTEG 2065
+ A++ D + +A + AG + V + +PP ++++ ++ G
Sbjct: 29003 VTALSEGDTYEFRVLAKNAAGVISKGSESTGPVTCRDEYAPPKAELDARLHGDLVTIRAG 29062
Query: 2066 QTLDLNCVVAGSAHAQVTWYRRGGSLP----PHTQVHGSRLR--LPQVSPADSGEYVCRV 2119
L L+ V G ++ W + L Q G R + +DSG+Y V
Sbjct: 29063 SDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSLQYTGKRATAVIKFCDRSDSGKYTLTV 29122
Query: 2120 ENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA------EGQTLDLNC 2173
+N SG K S+ V VL GP G R+ +A +G +
Sbjct: 29123 KNASGTKAVSVMVKVLDS--PGPC-----GKLTVSRVTQEKCTLAWSLPQEDGGAEITHY 29175
Query: 2174 VVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHV-----VGTSGPLE 2228
+V + +++ W G P L++ + EY+ V G P+E
Sbjct: 29176 IVERRETSRLNWVIVEGECPTLSYVVTRLIK--------NNEYIFRVRAVNKYGPGVPVE 29227
Query: 2229 ASVLVTIEASVIPGP 2243
+ +V + IP P
Sbjct: 29228 SEPIVARNSFTIPSP 29242
Score = 34.3 bits (77), Expect = 2.8
Identities = 37/165 (22%), Positives = 61/165 (36%), Gaps = 24/165 (14%)
Query: 1740 DAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKS 1799
D Y C R S +L EA +E + +++ +V+
Sbjct: 12439 DEAEYSCEVRTARTSGM--LTVLEEEAVFTKNLANIEVSETDTIKLVCEVS--------K 12488
Query: 1800 PAYTLVWTR-----LHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTAT 1854
P ++W + + G+ IL I+N L DAG Y C + + G
Sbjct: 12489 PGAEVIWYKGDEEIIETGRYEILTEGRKRILVIQNAHLEDAGNYNCRLPS--SRTDGKVK 12546
Query: 1855 LHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEW 1899
+H A+ +S P L + G+ AEF CS + P ++W
Sbjct: 12547 VHELAAEFIS------KPQNLEILEGEKAEFVCSISKESFP-VQW 12584
Score = 34.3 bits (77), Expect = 2.8
Identities = 40/216 (18%), Positives = 77/216 (35%), Gaps = 28/216 (12%)
Query: 2627 SVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH------GSH 2680
++ P +++ ++ ++ G+ L + V +P+ I+W K G L + + +
Sbjct: 24309 TIQPSLKLPFNTYSIQAGEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTV 24368
Query: 2681 LRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAP----GSSMPIRIESSSS 2736
L + + + D G+Y A N+ ++ + V G P P S + S
Sbjct: 24369 LHIKEGNKDDFGKYTVTATNSAGTATENLSVIVLEKPGPPVGPVRFDEVSADFVVISWEP 24428
Query: 2737 HVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVM 2796
G N +V + TWH ++ +R + EY R+
Sbjct: 24429 PAYTGGCQISNYIVEKRDTTTTTWHMVSATV--------ARTTIKITKLKTGTEYQFRIF 24480
Query: 2797 -----GSSGPLEASVLVTIEASGSSAVHVPAPGGAP 2827
G S PL++ ++ P P G P
Sbjct: 24481 AENRYGKSAPLDSKAVIV-----QYPFKEPGPPGTP 24511
Score = 34.3 bits (77), Expect = 2.8
Identities = 38/189 (20%), Positives = 68/189 (35%), Gaps = 24/189 (12%)
Query: 2741 GETLDLNCVVPGQAHAQVTWHKRGGSL-PSHHQTRGS--------RLRLHHVSPADSGEY 2791
GE + + VTW+K G + P + + + +L ++ V+ D EY
Sbjct: 31704 GENVRFGVTITVHPEPHVTWYKSGQKIKPGDNDKKYTFESDKGLYQLTINSVTTDDDAEY 31763
Query: 2792 VCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGA--PPIRIEPSSSRVAEGQTLDLKCV 2849
G +T+ +H P P + +++ EGQ++ +
Sbjct: 31764 TVVARNKYGEDSCKAKLTV------TLHPPPTDSTLRPMFKRLLANAECQEGQSVCFEIR 31817
Query: 2850 VPGQAHAQVTWHKRGGNL---PARHQVHGPL----LRLNQVSPADSGEYSCQVTGSSGTL 2902
V G + W K G L P +H L L + P D+G Y T ++G+
Sbjct: 31818 VSGIPPPTLKWEKDGQPLSLGPNIEIIHEGLDYYALHIRDTLPEDTGYYRVTATNTAGST 31877
Query: 2903 EASVLVTIE 2911
+ +E
Sbjct: 31878 SCQAHLQVE 31886
Score = 33.9 bits (76), Expect = 3.7
Identities = 15/39 (38%), Positives = 23/39 (58%)
Query: 440 WRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYT 478
W N + S+ + T+TS GR L ++DV + DQG Y+
Sbjct: 2299 WYHNDVELKSNGKYTITSRRGRQNLTVKDVTKEDQGEYS 2337
Score = 33.9 bits (76), Expect = 3.7
Identities = 27/94 (28%), Positives = 39/94 (41%), Gaps = 4/94 (4%)
Query: 395 PDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVT 454
PD+ E PP ++TP ++++ S GQ F C G + +W I
Sbjct: 3336 PDQ--EMPVYPPAIITPLQDTV-TSEGQPARFQCRVSGTDLKV-SWYSKDKKIKPSRFFR 3391
Query: 455 VTSEGGRGTLIIRDVKESDQGAYTCEAMNARGMV 488
+T L I + D+G YT A NA G V
Sbjct: 3392 MTQFEDTYQLEIAEAYPEDEGTYTFVASNAVGQV 3425
Score = 33.9 bits (76), Expect = 3.7
Identities = 19/67 (28%), Positives = 24/67 (35%)
Query: 420 RGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTC 479
+G C G P I W N I + ++ L + DV D G Y C
Sbjct: 4313 KGDATQLACKVTGTPPIKITWFANDREIKESSKHRMSFVESTAVLRLTDVGIEDSGEYMC 4372
Query: 480 EAMNARG 486
EA N G
Sbjct: 4373 EAQNEAG 4379
Score = 33.9 bits (76), Expect = 3.7
Identities = 22/86 (25%), Positives = 35/86 (40%), Gaps = 7/86 (8%)
Query: 3484 QALPSVLINIRTSVQ-TVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG------IVQS 3536
Q P + ++++ TV G +E G P+P++TW+K L+ V
Sbjct: 13685 QEAPEIFLDVKLLAGLTVKAGTKIELPATVTGKPEPKITWTKADMILKQDKRITIENVPK 13744
Query: 3537 GGVVRIAHVELADAGQYRCTATNAAG 3562
V I + +D G Y A N G
Sbjct: 13745 KSTVTIVDSKRSDTGTYIIEAVNVCG 13770
Score = 33.9 bits (76), Expect = 3.7
Identities = 43/194 (22%), Positives = 77/194 (39%), Gaps = 32/194 (16%)
Query: 2454 LDLNCLVAGQAHAQVTW---HKRGGS-LPARH------------QVHGSRLRLLQVTPAD 2497
LDL+ AG+ H + W K GGS + H +V+ ++ L+ +
Sbjct: 14289 LDLHVTDAGRKHIAIAWKPPEKNGGSPIIGYHVEMCPVGTEKWMRVNSRPIKDLKFKVEE 14348
Query: 2498 S----GEYVCRV--VGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTL 2551
EYV RV V + G E S I + + + +E+ + G L
Sbjct: 14349 GVVPDKEYVLRVRAVNAIGVSEPS---EISENVVAKDPD-CKPTIDLETHDIIVIEGEKL 14404
Query: 2552 DLNCLVASQAPHTITWYKRGGSLPSRHQI------VGSRLRIPQVTPADSGEYVCHVSNG 2605
+ + T++W+K G + + ++ + + L +P+ AD+G Y + N
Sbjct: 14405 SIPVPFRAVPVPTVSWHKDGKEVKASDRLTMKNDHISAHLEVPKSVRADAGIYTITLENK 14464
Query: 2606 AGSRETSLIVTIQG 2619
GS S+ V + G
Sbjct: 14465 LGSATASINVKVIG 14478
Score = 33.9 bits (76), Expect = 3.7
Identities = 27/101 (26%), Positives = 45/101 (44%), Gaps = 8/101 (7%)
Query: 3470 GPWGKAQASAQLVIQALPSVL--INIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGG 3527
GP G+ Q Q P+V ++++ +Q ++ G + + G P P W+K G
Sbjct: 15085 GPPGETQPVTVAEPQEPPAVELDVSVKGGIQ-IMAGKTLRIPAVVTGRPVPTKVWTKEEG 15143
Query: 3528 HLRPGIVQSGGVVRIAHVELADA-----GQYRCTATNAAGT 3563
L V V + + + DA G+Y TATN+ G+
Sbjct: 15144 ELDKDRVVIDNVGTKSELIIKDALRKDHGRYVITATNSCGS 15184
Score = 33.9 bits (76), Expect = 3.7
Identities = 32/134 (23%), Positives = 59/134 (44%), Gaps = 16/134 (11%)
Query: 3552 QYRCTATNAAGTTQ----SHVLLLVQAL--PQISMPQEVR----VPAGSAAVFPCIASGY 3601
++R A N AG + + V+ + L P + + VR V AG SG
Sbjct: 16492 KFRVRAVNIAGIGEPGEVTDVIEMKDRLVSPDLQLDASVRDRIVVHAGGVIRIIAYVSGK 16551
Query: 3602 PTPDISWSKLDGSLPPDSRLE----NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQ 3657
P P ++W+ + +LP ++ +E ++ +++ + + G Y A N G+ K +
Sbjct: 16552 PPPTVTWNMNERTLPQEATIETTAISSSMVIKNCQRSHQGVYSLLAKNEAGERKKTIIVD 16611
Query: 3658 VPERVVPYFTQTPY 3671
V + VP TP+
Sbjct: 16612 VLD--VPGPVGTPF 16623
Score = 33.9 bits (76), Expect = 3.7
Identities = 27/104 (25%), Positives = 43/104 (41%), Gaps = 19/104 (18%)
Query: 1870 IHPPQ----------LTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILR 1919
+HPP+ +TV+ GQ G P P + WT G++ + + I
Sbjct: 17903 LHPPEVELDVTCRDVITVRVGQTIRILARVKGRPEPDITWT--KEGKVLVREKRVDLIQD 17960
Query: 1920 LPAVE-------PTDQAQYLCRAHSSAGQQVARAVLHVHGGGGP 1956
LP VE D +Y+ A +S+G A+++V GP
Sbjct: 17961 LPRVELQIKEAVRADHGKYIISAKNSSGHAQGSAIVNVLDRPGP 18004
Score = 33.9 bits (76), Expect = 3.7
Identities = 47/226 (20%), Positives = 81/226 (35%), Gaps = 25/226 (11%)
Query: 2523 RLSGSHSQGVAYPVRI-ESSSASLANGHTLDLNCLVASQAPHTITWYKR---GGSLPSRH 2578
R+ + G+ P E AS A LN + +++ ++ W K GGS + +
Sbjct: 20940 RVMAENEYGIGEPTETTEPVKASEAPSPPDSLNIMDITKSTVSLAWPKPKHDGGSKITGY 20999
Query: 2579 QIVGSRLRIPQVTPADSGEYV-CHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESS 2637
I R Q T + + + C V N E + V S P S P+ ++
Sbjct: 21000 VIEAQRKGSDQWTHITTVKGLECVVRNLTEGEEYTFQVMAVNSAGRSAPRESRPVIVKEQ 21059
Query: 2638 SPT--------------VVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTH------ 2677
+ G + + V +P+ +TW K L + +
Sbjct: 21060 TMLPELDLRGIYQKLVIAKAGDNIKVEIPVLGRPKPTVTWKKGDQILKQTQRVNFETTAT 21119
Query: 2678 GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAP 2723
+ L +++ +DSG Y A N + + I I V G P+ P
Sbjct: 21120 STILNINECVRSDSGPYPLTARNIVGEVGDVITIQVHDIPGPPTGP 21165
Score = 33.9 bits (76), Expect = 3.7
Identities = 43/165 (26%), Positives = 66/165 (40%), Gaps = 26/165 (15%)
Query: 3552 QYRCTATNAAGTTQ--SHVLLLVQAL-----PQISMPQE----VRVPAGSAAVFPCIASG 3600
++R A NA G+ S V+ + + P I +P E V+ AG++ SG
Sbjct: 26839 EFRVFARNAVGSISNPSEVVGPITCIDSYGGPVIDLPLEYTEVVKYRAGTSVKLRAGISG 26898
Query: 3601 YPTPDISWSKLDGSLPPDSRL-ENNMLMLPSVRPQDA-----GTYVCTATNRQGKVKAFA 3654
P P I W K D L ++ + N L S+ +DA G Y N G A
Sbjct: 26899 KPAPTIEWYKDDKELQTNALVCVENTTDLASILIKDADRLNSGCYELKLRNAMGSASATI 26958
Query: 3655 HLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADG 3699
+Q+ ++ P P F + K I + +RP + DG
Sbjct: 26959 RVQILDKPGP--PGGPIEFKTVTAEK-------ITLLWRPPADDG 26994
Score = 33.9 bits (76), Expect = 3.7
Identities = 22/78 (28%), Positives = 32/78 (41%), Gaps = 4/78 (5%)
Query: 2062 VTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHG----SRLRLPQVSPADSGEYVC 2117
V G ++ L G W + +L +H S L + + D+G+Y
Sbjct: 28369 VRAGASIRLFIAYQGRPTPTAVWSKPDSNLSLRADIHTTDSFSTLTVENCNRNDAGKYTL 28428
Query: 2118 RVENGSGPKEASITVSVL 2135
VEN SG K + TV VL
Sbjct: 28429 TVENNSGSKSITFTVKVL 28446
Score = 33.9 bits (76), Expect = 3.7
Identities = 27/110 (24%), Positives = 43/110 (39%), Gaps = 7/110 (6%)
Query: 399 DEFGCMPPQVVTPPR---ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTV 455
DE+ PP+ R + + G + G P P I W + +V++
Sbjct: 29039 DEYA--PPKAELDARLHGDLVTIRAGSDLVLDAAVGGKPEPKIIWTKGDKELDLCEKVSL 29096
Query: 456 TSEGGRGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPC 505
G R T +I+ SD G YT NA G +++++ GPC
Sbjct: 29097 QYTGKRATAVIKFCDRSDSGKYTLTVKNASGT--KAVSVMVKVLDSPGPC 29144
Score = 33.9 bits (76), Expect = 3.7
Identities = 23/83 (27%), Positives = 34/83 (40%), Gaps = 1/83 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P +VT +++ +S F A G P P W + I + ++ + G L
Sbjct: 32852 PVIVTGLQDTTVSS-DSVAKFAVKATGEPRPTAIWTKDGKAITQGGKYKLSEDKGGFFLE 32910
Query: 466 IRDVKESDQGAYTCEAMNARGMV 488
I SD G YTC N+ G V
Sbjct: 32911 IHKTDTSDSGLYTCTVKNSAGSV 32933
Score = 33.5 bits (75), Expect = 4.8
Identities = 26/84 (30%), Positives = 31/84 (36%), Gaps = 1/84 (1%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP VT P S G V G I W + S +T E +L
Sbjct: 4205 PPSFVTKPG-SKDVLPGSAVCLKSTFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSL 4263
Query: 465 IIRDVKESDQGAYTCEAMNARGMV 488
+ VK SD G YTC+ N G V
Sbjct: 4264 ELYLVKTSDSGTYTCKVSNVAGGV 4287
Score = 33.5 bits (75), Expect = 4.8
Identities = 18/74 (24%), Positives = 29/74 (39%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
ES + RG T F G + W + I + +T E +L + ++
Sbjct: 4493 ESTSSLRGGTAAFQATLKGSLPITVTWLKDSDEITEDDNIRMTFENNVASLYLSGIEVKH 4552
Query: 474 QGAYTCEAMNARGM 487
G Y C+A N G+
Sbjct: 4553 DGKYVCQAKNDAGI 4566
Score = 33.5 bits (75), Expect = 4.8
Identities = 19/59 (32%), Positives = 28/59 (47%), Gaps = 1/59 (1%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTC 479
G + F C+ + T I W + +I P+ ++G L I DV+ SD G YTC
Sbjct: 11133 GSSAIFECL-VSPSTAITTWMKDGSNIRESPKHRFIADGKDRKLHIIDVQLSDAGEYTC 11190
Score = 33.5 bits (75), Expect = 4.8
Identities = 20/77 (25%), Positives = 28/77 (36%), Gaps = 1/77 (1%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP T P E G T C + + W N I + + ++G L
Sbjct: 12283 PPVEFTKPLEDQTVEEGATAVLEC-EVSRENAKVKWFKNGTEILKSKKYEIVADGRVRKL 12341
Query: 465 IIRDVKESDQGAYTCEA 481
+I D D YTC+A
Sbjct: 12342 VIHDCTPEDIKTYTCDA 12358
Score = 33.5 bits (75), Expect = 4.8
Identities = 20/84 (23%), Positives = 35/84 (41%), Gaps = 2/84 (2%)
Query: 405 PPQVVTPPR--ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG 462
PP++ P+ ++I G++ G P P I W + + R+ + S
Sbjct: 22540 PPRISMDPKYKDTIVVHAGESFKVDADIYGKPIPTIQWIKGDQELSNTARLEIKSTDFAT 22599
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
+L ++D D G Y +A N G
Sbjct: 22600 SLSVKDAVRVDSGNYILKAKNVAG 22623
Score = 33.5 bits (75), Expect = 4.8
Identities = 62/289 (21%), Positives = 107/289 (37%), Gaps = 35/289 (12%)
Query: 2888 SGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCV 2947
SGE V G + V +T +PS P + +++ +G + ++ V
Sbjct: 26352 SGENEFGV-GIPAETKEGVKITEKPSPPEKLGVTSISKDSVSLTWLKPEHDGGSRIVHYV 26410
Query: 2948 VPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCR--AASGPGPEQEASF 3005
V Q W K + H G + ++ EY R A + G
Sbjct: 26411 VEALEKGQKNWVKCAVAKSTHHVVSGLR---------ENSEYFFRVFAENQAGLSDPREL 26461
Query: 3006 TVTVPPSEGSSYRLRSPVISIDP-PSSTVQQGQDASFKCLIHDGAAPISLEWKTRN---- 3060
+ V E +L P I + PS TV ++ K I P+ +R+
Sbjct: 26462 LLPVLIKE----QLEPPEIDMKNFPSHTVYVRAGSNLKVDIPISGKPLPKVTLSRDGVPL 26517
Query: 3061 -QELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV---HGPPT--- 3113
+ N I+ I + + ++ G Y A+N+ G ++ +N+ V GPPT
Sbjct: 26518 KATMRFNTEITAENLTINLKESVTADAGRYEITAANSSGTTKAFINIVVLDRPGPPTGPV 26577
Query: 3114 -VSVLPEGPVWVK------VGKAVTLECVSAGEPRSSARWTRISSTPAK 3155
+S + E V +K G + + S+A WT +S+T A+
Sbjct: 26578 VISDITEESVTLKWEPPKYDGGSQVTNYILLKRETSTAVWTEVSATVAR 26626
Score = 33.5 bits (75), Expect = 4.8
Identities = 20/74 (27%), Positives = 30/74 (40%)
Query: 413 RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKES 472
R S+ A G+ V G P P + WR + ++ S R ++ + L I V +
Sbjct: 27278 RTSVIAKAGEDVQVLIPFKGRPPPTVTWRKDEKNLGSDARYSIENTDSSSLLTIPQVTRN 27337
Query: 473 DQGAYTCEAMNARG 486
D G Y N G
Sbjct: 27338 DTGKYILTIENGVG 27351
Score = 33.5 bits (75), Expect = 4.8
Identities = 23/94 (24%), Positives = 38/94 (40%), Gaps = 4/94 (4%)
Query: 413 RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKES 472
++++ G ++ G P P+I W + S R + + LI+ V
Sbjct: 29453 KKTVTIRAGASLRLMVSVSGRPPPVITWSKQGIDLAS--RAIIDTTESYSLLIVDKVNRY 29510
Query: 473 DQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCP 506
D G YT EA N G ++++ GPCP
Sbjct: 29511 DAGKYTIEAENQSGKKSATV--LVKVYDTPGPCP 29542
Score = 33.1 bits (74), Expect = 6.2
Identities = 23/73 (31%), Positives = 30/73 (41%), Gaps = 1/73 (1%)
Query: 415 SIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPS-HPRVTVTSEGGRGTLIIRDVKESD 473
S + GQT F +G P P W + I + + V E G +LII SD
Sbjct: 1465 SFKCLEGQTARFDLKVVGRPMPETFWFHDGQQIVNDYTHKVVIKEDGTQSLIIVPATPSD 1524
Query: 474 QGAYTCEAMNARG 486
G +T A N G
Sbjct: 1525 SGEWTVVAQNRAG 1537
Score = 33.1 bits (74), Expect = 6.2
Identities = 19/82 (23%), Positives = 31/82 (37%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP+ V S G + C G P + W N +P+ + +T +
Sbjct: 5422 PPKFVKKLEASKIVKAGDSSRLECKIAGSPEIRVVWFRNEHELPASDKYRMTFIDSVAVI 5481
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
+ ++ D G + CEA N G
Sbjct: 5482 QMNNLSTEDSGDFICEAQNPAG 5503
Score = 33.1 bits (74), Expect = 6.2
Identities = 23/96 (23%), Positives = 34/96 (35%), Gaps = 5/96 (5%)
Query: 1866 PVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGG-----PGGQLPAKAQIHGGILRL 1920
P + P Q+T++ G+ G P PT +W G L IL +
Sbjct: 18899 PPKILMPEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILII 18958
Query: 1921 PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGP 1956
V D Y A +S+G + + V GP
Sbjct: 18959 KDVTRKDSGYYSLTAENSSGTDTQKIKVVVMDAPGP 18994
Score = 33.1 bits (74), Expect = 6.2
Identities = 34/142 (23%), Positives = 53/142 (37%), Gaps = 3/142 (2%)
Query: 1645 YTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVP--QGGSHSLRCQVSG 1702
Y + C G + V G + E +AP + R I+ GGS L + G
Sbjct: 22909 YNFRICAINKAGVGEHADVPGPIIVEEKLEAPDIDLDLELRKIINIRAGGSLRLFVPIKG 22968
Query: 1703 SPPHYFYWSREDGRPVPSGT-QQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAEL 1761
P W + DG + + L +V D+G Y T N + ++ +
Sbjct: 22969 RPTPEVKWGKVDGEIRDAAIIDVTSSFTSLVLDNVNRYDSGKYTLTLENSSGTKSAFVTV 23028
Query: 1762 LVTEAPSKPITVTVEEQRSQSV 1783
V + PS P+ + V E SV
Sbjct: 23029 RVLDTPSPPVNLKVTEITKDSV 23050
Score = 33.1 bits (74), Expect = 6.2
Identities = 23/72 (31%), Positives = 32/72 (44%), Gaps = 2/72 (2%)
Query: 415 SIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQ 474
SIQA G+ + IG P P I+W + + RV V L I++ + D
Sbjct: 24322 SIQA--GEDLKIEIPVIGRPRPNISWVKDGEPLKQTTRVNVEETATSTVLHIKEGNKDDF 24379
Query: 475 GAYTCEAMNARG 486
G YT A N+ G
Sbjct: 24380 GKYTVTATNSAG 24391
Score = 33.1 bits (74), Expect = 6.2
Identities = 26/107 (24%), Positives = 43/107 (40%), Gaps = 7/107 (6%)
Query: 1687 IVPQGGSHSLRCQVSGSPPHYFYWSREDG----RPVPSGTQQRHQGSELHFPSVQPSDAG 1742
IV G S ++ G P WS+ D R T R + L + +D+G
Sbjct: 26197 IVKAGASFTMTVPFRGRPVPNVLWSKPDTDLRTRAYVDTTDSR---TSLTIENANRNDSG 26253
Query: 1743 VYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADV 1789
Y T +N+ + + + V + P P +TV++ +S DV
Sbjct: 26254 KYTLTIQNVLSAASLTLVVKVLDTPGPPTNITVQDVTKESAVLSWDV 26300
Score = 32.7 bits (73), Expect = 8.2
Identities = 19/65 (29%), Positives = 26/65 (40%)
Query: 423 TVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAM 482
+ TF G P I W + + V ++ TL IR V G YTC+A
Sbjct: 5064 SATFQSTVAGSPPISITWLKDDQILDEDDNVYISFVDSVATLQIRSVDNGHSGRYTCQAK 5123
Query: 483 NARGM 487
N G+
Sbjct: 5124 NESGV 5128
Score = 32.7 bits (73), Expect = 8.2
Identities = 20/81 (24%), Positives = 34/81 (41%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P + I+ +G V C G P ++W + + S + + SE ++
Sbjct: 7398 PPIFRKKPHPIETLKGADVHLECELQGTPPFHVSWYKDKRELRSGKKYKIMSENFLTSIH 7457
Query: 466 IRDVKESDQGAYTCEAMNARG 486
I +V +D G Y C+A N G
Sbjct: 7458 ILNVDAADIGEYQCKATNDVG 7478
Score = 32.7 bits (73), Expect = 8.2
Identities = 44/184 (23%), Positives = 63/184 (34%), Gaps = 24/184 (13%)
Query: 1668 CLPETNQAPLVV-----EVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSG- 1721
C P A L V E H + +G + ++ CQ S P W R P G
Sbjct: 8731 CGPHIASAKLTVIEPAWERHLQDVTLKEGQTCTMTCQFS-VPNVKSEWFRNGRILKPQGR 8789
Query: 1722 --TQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQR 1779
T+ H+ +L V+ D G Y C +L S R E + + + V E +
Sbjct: 8790 HKTEVEHKVHKLTIADVRAEDQGQYTCKYEDLETSAELRIEAEPIQFTKRIQNIVVSEHQ 8849
Query: 1780 SQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFNG-----ILTIRNVQLSD 1834
S TF C T W + ++ +F +TI NV D
Sbjct: 8850 S--------ATFECEVSFDDAIVT--WYKGPTELTESQKYNFRNDGRCHYMTIHNVTPDD 8899
Query: 1835 AGTY 1838
G Y
Sbjct: 8900 EGVY 8903
Score = 32.7 bits (73), Expect = 8.2
Identities = 22/91 (24%), Positives = 36/91 (39%), Gaps = 3/91 (3%)
Query: 1683 PARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQG---SELHFPSVQPS 1739
P + + G + V G P W + + V S H+ S L V
Sbjct: 18905 PEQITIKAGKKLRIEAHVYGKPHPTCKWKKGEDEVVTSSHLAVHKADSSSILIIKDVTRK 18964
Query: 1740 DAGVYICTCRNLHQSNTSRAELLVTEAPSKP 1770
D+G Y T N ++T + +++V +AP P
Sbjct: 18965 DSGYYSLTAENSSGTDTQKIKVVVMDAPGPP 18995
Score = 32.7 bits (73), Expect = 8.2
Identities = 30/118 (25%), Positives = 53/118 (44%), Gaps = 11/118 (9%)
Query: 1750 NLHQSNTSRAELLVTEAPSKPITVTVEEQRSQ-SVRPGADVTFICTAKSKSPAYTLVWT- 1807
N+ Q +S +++L +A + I +E S S+ G +T C A + P + W+
Sbjct: 33308 NMTQLESSTSKML--KAGIRGIPPKIEALPSDISIDEGKVLTVAC-AFTGEPTPEVTWSC 33364
Query: 1808 ---RLHN---GKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA 1859
++H+ G+ D L I +VQ D G Y + N F D T +H+++
Sbjct: 33365 GGRKIHSQEQGRFHIENTDDLTTLIIMDVQKQDGGLYTLSLGNEFGSDSATVNIHIRS 33422
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 358 bits (920), Expect = 5e-98
Identities = 214/567 (37%), Positives = 274/567 (48%), Gaps = 43/567 (7%)
Query: 1122 EVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHH 1181
E QC C PG G C C GY G C C C C+P+TG C C +
Sbjct: 981 ESGQCWCQPGVTGKKCDRCAHGYFNFQEG----GCTACECSHLGNNCDPKTGRCI-CPPN 1035
Query: 1182 TEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGH 1241
T G +C +C P +G + C+ C C G C ++T C+ C P
Sbjct: 1036 TIGEKCSKCAPNTWGHS---ITTGCKACNC---STVGSLDFQCNVNTG---QCN-CHPKF 1085
Query: 1242 SGRHCERCAPGYYGNPSQGQPCQR-DSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVE 1300
SG C C+ G++ P C D +PG CD + S D GQC CK VE
Sbjct: 1086 SGAKCTECSRGHWNYPR----CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVE 1141
Query: 1301 GLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVN 1360
G+ C CRP F L A NP GC C+C G T QC+ + + LI T Q +
Sbjct: 1142 GIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEA---KGLIRTWVTLKAEQTILPLV 1198
Query: 1361 PQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLS 1420
+ T + V PE L E FYW+LPE ++G K+ AYGGKL+Y +
Sbjct: 1199 DEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIY 1258
Query: 1421 YTAGPQ-GSPLSDPDVQITGNNI----MLVASQPALQGPERRSYEIMFREEFWRRPDGQP 1475
+ A + G +P V I G ++V A + +EI E+ W+ P
Sbjct: 1259 FEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDP 1318
Query: 1476 -----ATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNR--PRALEVE 1528
TRE L L D+ +LI+AT+ + + IS +S+EVA+ G P A +E
Sbjct: 1319 RVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIE 1378
Query: 1529 ECRCPPGYIGLSCQDCAPGYTRTGS-------GLYLGHCELCECNGHSDLCHPETGACSQ 1581
+C CP GY GLSC+ C PG+ R S G LG C C+CNGHS LC PET C
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
Query: 1582 CQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTAC 1641
CQH+ AG+FCE CA GYYG G P DCQ CACPL + N FS +C + G YRCTAC
Sbjct: 1439 CQHHTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
Query: 1642 EPGYTGQYCEQCGPGYVGNPSVQGGQC 1668
GY GQYCE+C PGY G+P GG C
Sbjct: 1498 PRGYEGQYCERCAPGYTGSPGNPGGSC 1524
Score = 331 bits (848), Expect = 1e-89
Identities = 199/590 (33%), Positives = 275/590 (46%), Gaps = 61/590 (10%)
Query: 1118 DPALEVEQCSCPPGYRGPSCQDCDTGYTRTP--SGLYLGT--CERCSCHGHSEACEPET- 1172
DPA +C C G SC C G+ + P +G +L CE C+CHG +E C +
Sbjct: 299 DPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDEN 358
Query: 1173 -----------------GACQGCQHHTEGPRCEQCQPGYYGD--AQRGTPQDCQLCPCYG 1213
G C C +T G CE C G++ P+ CQ PC+
Sbjct: 359 VARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQ--PCHC 416
Query: 1214 DPAAGQAAHTCFLDTDGH------PTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDS 1267
DP G C D + H P C G G C+RCA GY G P C+
Sbjct: 417 DPI-GSLNEVCVKD-EKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD----CK--- 467
Query: 1268 QVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
CNC GS ++ G C CK VEG CS C+ F+L N GC CFC
Sbjct: 468 ------ACNCSGLGS-KNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
Query: 1328 MGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNF 1387
G++ +C SS +T I D G+ L + R+ + P+ +S
Sbjct: 521 SGVSNRCQSSYWTYGKIQ------DMSGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEA 574
Query: 1388 AQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLS---DPDVQITGNNIML 1444
Q S+YW P Y G+K+ A GG+L +T+SY + + + GN++ +
Sbjct: 575 RQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSI 634
Query: 1445 VASQPA--LQGPERRSYEIMFREE-FWRRPDGQPATREHLLMALADLDELLIRATFS-SV 1500
+Q L E + ++ +EE F P R+ + LA+L +L++ T+S +
Sbjct: 635 STAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGM 694
Query: 1501 PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHC 1560
+S+V+LE A P++ A VE C+CPPGY G SC+ C P + R ++ G C
Sbjct: 695 DAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGIC 754
Query: 1561 ELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNP 1620
E C+C GH++ C TG C C+ + G +C+ C PG+YG+ T GT EDCQPCACPL P
Sbjct: 755 EPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIP 814
Query: 1621 ENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLP 1670
N FS TC + G C C GYTG CE+C GY G PSV GG C P
Sbjct: 815 SNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQP 864
Score = 327 bits (838), Expect = 2e-88
Identities = 203/613 (33%), Positives = 285/613 (46%), Gaps = 63/613 (10%)
Query: 730 ECRCPIGYSGLSCESC-DAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTE 788
+C C G +G C+ C +F GG C+ C C+ ++CDP G C+ C NT
Sbjct: 984 QCWCQPGVTGKKCDRCAHGYFNFQEGG-----CTACECSHLGNNCDPKTGRCI-CPPNTI 1037
Query: 789 GPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTG 848
G +C+KC +G ++ T C+ C C + + C ++T GQ C P ++G
Sbjct: 1038 GEKCSKCAPNTWGHSI---TTGCKACNCSTVGS---LDFQCNVNT-GQCNCH---PKFSG 1087
Query: 849 RRCESCAPGYEGNP-------IQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGR 901
+C C+ G+ P PG + E +C G C CK NV G
Sbjct: 1088 AKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQ----CTCKVNVEGI 1143
Query: 902 LCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAAST 961
C+ C G F L +NP GC C+C G + C+ + E L + A
Sbjct: 1144 HCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQ 1203
Query: 962 HTTNEGIFSPTPGELGFSSFHR--LLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQP 1019
HTT +GI P + R L P++W LP +F G K+ +YGG+L++ + ++
Sbjct: 1204 HTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEARE 1263
Query: 1020 GSTPLHGQPLVVLQGN-----NIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQP--- 1071
+ P V+++G II+ H A P GQ + + E+ W+ P
Sbjct: 1264 ETGFSTYNPQVIIRGGTPTHARIIVRHMAA--PLIGQLTRHEIEMTEKEWKYYGDDPRVH 1321
Query: 1072 --ATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEE--TGQDPALEVEQCS 1127
TRE L L I +LI+A+Y +SR+S ISM+VA T PA +E+C
Sbjct: 1322 RTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKCD 1381
Query: 1128 CPPGYRGPSCQDCDTGYTRTPS-------GLYLGTCERCSCHGHSEACEPETGACQGCQH 1180
CP GY G SC+ C G+ R S G LGTC C C+GHS C+PET CQ CQH
Sbjct: 1382 CPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQH 1441
Query: 1181 HTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPG 1240
HT G CE+C GYYG +G P DCQ C C ++ + +C + C AC G
Sbjct: 1442 HTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG 1500
Query: 1241 HSGRHCERCAPGYYGNP-SQGQPCQRDSQVPGPIGCNCDPQGSVSSQCD-AAGQCQCKAQ 1298
+ G++CERCAPGY G+P + G CQ C CDP GS+ CD G C C+
Sbjct: 1501 YEGQYCERCAPGYTGSPGNPGGSCQE---------CECDPYGSLPVPCDPVTGFCTCRPG 1551
Query: 1299 VEGLTCSHCRPHH 1311
G C C+ H
Sbjct: 1552 ATGRKCDGCKHWH 1564
Score = 323 bits (829), Expect = 2e-87
Identities = 210/695 (30%), Positives = 307/695 (44%), Gaps = 118/695 (16%)
Query: 725 AHSVEECRCPIGYSGLSCESCDAHFTRVP--GGPYLGT--CSGCNCNGHASSCDPVY--- 777
A + C C G SC+ C F + P G +L C CNC+G A C Y
Sbjct: 301 ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEEC--YYDEN 358
Query: 778 -----------------GHCLNCQHNTEGPQCNKCKAGFFGDAMKAT--ATSCRPCPCPY 818
G C+NC NT G C C GFF + C+PC C
Sbjct: 359 VARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDP 418
Query: 819 IDASRRFSDTCFLDTD------GQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPV 872
I + ++ C D +C C G+ G C+ CA GY G P C+
Sbjct: 419 IGS---LNEVCVKDEKHARRGLAPGSCH-CKTGFGGVSCDRCARGYTGYP-----DCKAC 469
Query: 873 NQEIVRCDERGSMGTSG--EACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVS 930
N C GS C CK NV G C+ C G F+L N GC +CFC GVS
Sbjct: 470 N-----CSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVS 524
Query: 931 RHCTSSSWSRAQLHGAS-----EEPGHFSLTNAASTHTTNEGIFSPTPGELGFSSFHRLL 985
C SS W+ ++ S + PG + + + SP + + + L
Sbjct: 525 NRCQSSYWTYGKIQDMSGWYLTDLPGRIRVA------PQQDDLDSPQQISISNAEARQAL 578
Query: 986 SGPYFWSLPSRFLGDKVTSYGGELRFTVTQ--RSQPGSTPLHGQPLVVLQGNNIILEHHV 1043
Y+WS P+ +LG+K+ + GG+L FT++ + T Q +++L+GN++ +
Sbjct: 579 PHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSIS--T 636
Query: 1044 AQEP---SPGQPSTFIVPFREQAWQRPDGQ-PATREHLLMALAGIDTLLIRASYA-QQPA 1098
AQ+ P + T ++ +E+++ P R+ + LA + +L++ +Y+ A
Sbjct: 637 AQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDA 696
Query: 1099 ESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCER 1158
R+S ++++ AV T A VE C CPPGY G SC+ C + R ++ G CE
Sbjct: 697 IFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEP 756
Query: 1159 CSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAG 1218
C C GH+E+C+ TG C C+ HT GP C++C PG+YG+ +GT +DCQ C C + +
Sbjct: 757 CQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSN 816
Query: 1219 QAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPS----QGQPCQRDSQV----- 1269
+ TC LD CD C G++G CERCA GY+G PS QPCQ + +
Sbjct: 817 NFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIP 876
Query: 1270 --------------PGPIG----------------------CNCDPQGSVSSQCDA-AGQ 1292
PG G C C+ GS S C + GQ
Sbjct: 877 GSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQ 936
Query: 1293 CQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
C+C+A V+G C C+ F L ++ GC+PC C
Sbjct: 937 CECRANVQGQRCDKCKAGTFGLQSAR--GCVPCNC 969
Score = 252 bits (643), Expect = 7e-66
Identities = 153/435 (35%), Positives = 214/435 (49%), Gaps = 27/435 (6%)
Query: 505 CPDGHFYLEHS--AACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPG 562
C G F L+ C CFC G+++ CQS+ +I+ D G +T PG
Sbjct: 500 CKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQ-------DMSGWYLT--DLPG 550
Query: 563 TPPLSSTQLQIDPSLHEFQLVDLS----RRFLVHDSFWALPEQFLGNKVDSYGGSLRYNV 618
++ Q +D Q + +S R+ L H +W+ P +LGNK+ + GG L + +
Sbjct: 551 RIRVAPQQDDLDSP----QQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTI 606
Query: 619 RYELARGM--LEPVQRPDVVLMGAGYRL-LSRGHTPTQPGALNQRQVQFSEEHW-VHESG 674
Y+L E V + ++L G + ++ P + + EE + +H +
Sbjct: 607 SYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTH 666
Query: 675 RPVQRAELLQVLQSLEAVLIQTVYNTKMASV-GLSDIAMDTTVTHATSHGRAHSVEECRC 733
PV+R E + VL +L+ VL+Q Y+ M ++ LS + +++ V++ T A +VE C+C
Sbjct: 667 FPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQC 726
Query: 734 PIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCN 793
P GY+G SCESC RV G + G C C C GHA SCD V G CLNC+ +T GP C+
Sbjct: 727 PPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCD 786
Query: 794 KCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCES 853
KC GF+G+ K T+ C+PC CP S FS TC LD CD C GYTG RCE
Sbjct: 787 KCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCER 846
Query: 854 CAPGYEGNPIQPGGKCRP--VNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSF 911
CA GY G P PGG C+P N + SG CK GR C CADG F
Sbjct: 847 CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYF 906
Query: 912 HLSTRNPDGCLKCFC 926
+ C C C
Sbjct: 907 G-DAVDAKNCQPCRC 920
Score = 232 bits (592), Expect = 5e-60
Identities = 145/445 (32%), Positives = 207/445 (46%), Gaps = 43/445 (9%)
Query: 505 CPDGHFYLE--HSAACLPCFCFGITSVCQSTRRF-RDQIRLRFDQPDDFKGVNVTMPAQP 561
C G F L+ + C C+CFG T+ C + R + L+ +Q +P
Sbjct: 1148 CRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQ--------TILPLVD 1199
Query: 562 GTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSF-WALPEQFLGNKVDSYGGSLRYNVRY 620
++T+ + +DL R L + F W LPEQF G K+ +YGG L+Y + +
Sbjct: 1200 EALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYF 1259
Query: 621 ELARGMLEPVQRPDVVLMGAG---YRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRP- 676
E P V++ G R++ R G L + +++ +E+ W + P
Sbjct: 1260 EAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPR 1319
Query: 677 ----VQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTH--ATSHGRAHSVEE 730
V R + L +L + +LI+ Y M +S+I+M+ T A +E+
Sbjct: 1320 VHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEK 1379
Query: 731 CRCPIGYSGLSCESCDAHFTRV---PGG----PYLGTCSGCNCNGHASSCDPVYGHCLNC 783
C CP+GYSGLSCE+C F R+ PGG P LGTC C CNGH+S CDP C NC
Sbjct: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNC 1439
Query: 784 QHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACA 843
QH+T G C +C G++G +K C+ C CP I +S FS +C + C AC
Sbjct: 1440 QHHTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACP 1498
Query: 844 PGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEA----CRCKNNVV 899
GY G+ CE CAPGY G+P PGG C+ CD GS+ + C C+
Sbjct: 1499 RGYEGQYCERCAPGYTGSPGNPGGSCQE-----CECDPYGSLPVPCDPVTGFCTCRPGAT 1553
Query: 900 GRLCNECADGSFHLSTRNPDGCLKC 924
GR C DG H R C+ C
Sbjct: 1554 GRKC----DGCKHWHAREGWECVFC 1574
Score = 93.6 bits (231), Expect = 4e-18
Identities = 54/144 (37%), Positives = 71/144 (49%), Gaps = 17/144 (11%)
Query: 1532 CPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL-----CHPETGACSQCQHNA 1586
CP GY G C+ CA GY S + G C+ C+CN + D C +G+C C+
Sbjct: 835 CPVGYTGPRCERCAEGYFGQPS-VPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGT 893
Query: 1587 AGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYT 1646
G +CELCA GY+GDA ++CQPC C N FS C S +C C
Sbjct: 894 TGRYCELCADGYFGDAV--DAKNCQPCRC---NAGGSFSEVCHSQTG---QC-ECRANVQ 944
Query: 1647 GQYCEQCGPGYVGNPSVQGGQCLP 1670
GQ C++C G G S +G C+P
Sbjct: 945 GQRCDKCKAGTFGLQSARG--CVP 966
Score = 85.9 bits (211), Expect = 8e-16
Identities = 70/256 (27%), Positives = 93/256 (36%), Gaps = 84/256 (32%)
Query: 733 CPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHAS-----SCDPVYGHCL------ 781
CP+GY+G CE C + P P G+C C CN + SCD + G CL
Sbjct: 835 CPVGYTGPRCERCAEGYFGQPSVPG-GSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGT 893
Query: 782 --------------------------------------------NCQHNTEGPQCNKCKA 797
C+ N +G +C+KCKA
Sbjct: 894 TGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKA 953
Query: 798 GFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPG 857
G FG +A C PC C F F D + C C PG TG++C+ CA G
Sbjct: 954 GTFG---LQSARGCVPCNC------NSFGSKSF-DCEESGQC-WCQPGVTGKKCDRCAHG 1002
Query: 858 YEGNPIQPGG----KCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHL 913
Y Q GG +C + CD + C C N +G C++CA ++
Sbjct: 1003 YFN--FQEGGCTACECSHLGN---NCDPKTG------RCICPPNTIGEKCSKCAPNTWGH 1051
Query: 914 STRNPDGCLKCFCMGV 929
S GC C C V
Sbjct: 1052 SITT--GCKACNCSTV 1065
Score = 85.9 bits (211), Expect = 8e-16
Identities = 59/162 (36%), Positives = 82/162 (50%), Gaps = 13/162 (8%)
Query: 4229 TIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPI 4288
TIELEVRT SGLL + + A DF ++ L++G F Y LGSG+ + I
Sbjct: 2784 TIELEVRTEAESGLLFYMA-RINHA----DFATVQLRNGLPYFSYDLGSGDTHTMIPTKI 2838
Query: 4289 NDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVA--VNAKGSVYIGGAP-DVATLTG 4345
NDG+WH++ +R + G + VDG S R+ P A ++ G +Y+GG P + T
Sbjct: 2839 NDGQWHKIKIMRSKQEGILYVDG---ASNRTISPKKADILDVVGMLYVGGLPINYTTRRI 2895
Query: 4346 GRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTR 4387
G + I GCV+N LH A A QP H AN +
Sbjct: 2896 GPVTYSIDGCVRN--LHMAEAPADLEQPTSSFHVGTCFANAQ 2935
Score = 66.6 bits (161), Expect = 5e-10
Identities = 53/169 (31%), Positives = 80/169 (47%), Gaps = 16/169 (9%)
Query: 4198 APGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGK 4257
A Q G YF GF G F L + +E E RT+T +G+LL G + Q
Sbjct: 2932 ANAQRGTYFDGTGFAKAVGG-FKVGLDLL---VEFEFRTTTTTGVLL------GISSQKM 2981
Query: 4258 DFISLGLQDGHLVFRYQLGSGEARLVSEDPIN----DGEWHRVTALREGRRGSIQVDGEE 4313
D + + + D L+F G+G V + + DG+WH+VTA + R + VDG +
Sbjct: 2982 DGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQ 3041
Query: 4314 LVSGRSPGP-NVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361
V +SP P + + + V++GG PD G S GC+++L L
Sbjct: 3042 -VEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKL 3089
Score = 65.9 bits (159), Expect = 9e-10
Identities = 48/163 (29%), Positives = 79/163 (48%), Gaps = 17/163 (10%)
Query: 4209 DGFLAFPGHVF---SRSLPEVPE--TIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLG 4263
+G + F G + SR + P T+ + RT ++S LL++ +DF+S+
Sbjct: 2338 EGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATR-----DLRDFMSVE 2392
Query: 4264 LQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQV-----DGEELVSGR 4318
L DGH+ Y LGSG A +VS NDG+W T R ++ +I + + EE ++
Sbjct: 2393 LTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATS 2452
Query: 4319 SPGPNVAVNAKG--SVYIGGAPDVATLTGGRFSSGITGCVKNL 4359
S G N ++ K +Y GG P + L +GC+K++
Sbjct: 2453 SSGNNFGLDLKADDKIYFGGLPTLRNLRPEVNLKKYSGCLKDI 2495
Score = 55.1 bits (131), Expect = 2e-06
Identities = 33/135 (24%), Positives = 68/135 (50%), Gaps = 10/135 (7%)
Query: 3956 EFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHR 4015
+F+ + +L++ + + DF+S+ + GH++ Y+LGSG+A + S + G+W
Sbjct: 2367 KFRTFSSSALLMYLATRD--LRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKS 2424
Query: 4016 VSAERLNKDGSLRV-----NGGRPVLRSSPGKSQGLNLHT--LLYLGGVEPSVPLSPATN 4068
+ R+ K ++ + N + SS G + GL+L +Y GG+ L P N
Sbjct: 2425 FTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLRPEVN 2484
Query: 4069 MSAHFRGCVGEVSVN 4083
+ + GC+ ++ ++
Sbjct: 2485 LK-KYSGCLKDIEIS 2498
Score = 50.4 bits (119), Expect = 4e-05
Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 13/142 (9%)
Query: 3685 KFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMA 3744
+ I++ R ++ G+L Y + DF + L G P F +D GSG
Sbjct: 2782 RLTIELEVRTEAESGLLFYMARIN-----------HADFATVQLRNGLPYFSYDLGSGDT 2830
Query: 3745 TIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYP-D 3803
PT + G +H + ++RS +G L V D A S K LD+ LY+GG P +
Sbjct: 2831 HTMIPTKINDGQWHKIKIMRSKQEGILYV-DGASNRTISPKKADILDVVGMLYVGGLPIN 2889
Query: 3804 YGAIPKAGLSSGFIGCVRELRI 3825
Y ++ GCVR L +
Sbjct: 2890 YTTRRIGPVTYSIDGCVRNLHM 2911
Score = 48.9 bits (115), Expect = 1e-04
Identities = 36/119 (30%), Positives = 61/119 (51%), Gaps = 17/119 (14%)
Query: 4230 IELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSED-PI 4288
I + V+T+ A LL + G + + DF+++ ++ G + F + +GSG R+ D I
Sbjct: 2170 IVVNVKTAVADNLLFYLG-----SAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTI 2224
Query: 4289 NDGEWHRVTALREGRRGSIQV---DGEELV-------SGRSPGPNVA-VNAKGSVYIGG 4336
+D W+R+ A R GR G+I V DG + S PG + V+A +++GG
Sbjct: 2225 DDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGG 2283
Score = 48.1 bits (113), Expect = 2e-04
Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 4/159 (2%)
Query: 3945 TNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRS 4004
T + L +++E + A G+L + + DF ++ + G F Y+LGSG
Sbjct: 2777 TKVKNRLTIELEVRTEAESGLLFYMARINHA--DFATVQLRNGLPYFSYDLGSGDTHTMI 2834
Query: 4005 AEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLS 4064
+ G+WH++ R ++G L V+G SP K+ L++ +LY+GG+ +
Sbjct: 2835 PTKINDGQWHKIKIMRSKQEGILYVDGASN-RTISPKKADILDVVGMLYVGGLPINYTTR 2893
Query: 4065 PATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCY 4103
++ GCV + + DL S +G C+
Sbjct: 2894 RIGPVTYSIDGCVRNLHMAEAPADLEQP-TSSFHVGTCF 2931
Score = 47.4 bits (111), Expect = 3e-04
Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 11/150 (7%)
Query: 3950 ELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSG--LAVLRSAEP 4007
+L ++ EF+ GVLL G S D + + M+ L F + G+G AV + P
Sbjct: 2957 DLLVEFEFRTTTTTGVLL---GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVP 3013
Query: 4008 --LALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSP 4065
L G+WH+V+A ++ L V+G + +S S + + +++GG +
Sbjct: 3014 GHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFG 3073
Query: 4066 ATNMSAHFRGCVGEVSV---NGKRLDLTYS 4092
T S FRGC+ + + GK L++ ++
Sbjct: 3074 LTT-SIPFRGCIRSLKLTKGTGKPLEVNFA 3102
Score = 43.9 bits (102), Expect = 0.004
Identities = 40/147 (27%), Positives = 68/147 (46%), Gaps = 22/147 (14%)
Query: 3688 IKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ-PDFISFGLVGGRPEFRFDAGSGMATI 3746
+ FR S+ +L+Y LA R DF+S L G + +D GSGMA++
Sbjct: 2364 VMFKFRTFSSSALLMY------------LATRDLRDFMSVELTDGHIKVSYDLGSGMASV 2411
Query: 3747 RHPTPLALGHFHTVTLLRSLTQGSLIVGDL-----APVNGTSQGKFQGLDL--NEELYLG 3799
G + + TL R Q ++ + D+ + +S G GLDL ++++Y G
Sbjct: 2412 VSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFG 2471
Query: 3800 GYPDYGAI-PKAGLSSGFIGCVRELRI 3825
G P + P+ L + GC++++ I
Sbjct: 2472 GLPTLRNLRPEVNLKK-YSGCLKDIEI 2497
Score = 42.7 bits (99), Expect = 0.008
Identities = 37/156 (23%), Positives = 76/156 (48%), Gaps = 16/156 (10%)
Query: 3955 VEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAE-PLALGRW 4013
V K D +L + G S DF+++ M G + F +++GSG+ + + + W
Sbjct: 2172 VNVKTAVADNLLFYLG--SAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYW 2229
Query: 4014 HRVSAERLNKDGSLRV---NGGRPVL-------RSSPGKS-QGLNLHTLLYLGGVEPSVP 4062
+R+ A R ++G++ V +G + + S PG + ++ + +L++GG+ +
Sbjct: 2230 YRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLK 2289
Query: 4063 LSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQG 4098
+ A + F GC+GE + K + L ++F +G
Sbjct: 2290 KADAVRVIT-FTGCMGETYFDNKPIGL-WNFREKEG 2323
Score = 39.7 bits (91), Expect = 0.067
Identities = 31/121 (25%), Positives = 36/121 (29%), Gaps = 23/121 (19%)
Query: 829 CFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRC--------- 879
C LD + C G C+ C PG+ P + G E C
Sbjct: 296 CPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYY 355
Query: 880 DE-----------RGSMGTSGEACRCKNNVVGRLCNECADGSFH---LSTRNPDGCLKCF 925
DE RG G C N G C C DG F +S P C C
Sbjct: 356 DENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCH 415
Query: 926 C 926
C
Sbjct: 416 C 416
Score = 35.4 bits (80), Expect = 1.3
Identities = 32/144 (22%), Positives = 63/144 (43%), Gaps = 20/144 (13%)
Query: 3688 IKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIR 3747
++ FR + G+LL +++++ D + ++ + F D G+G T
Sbjct: 2960 VEFEFRTTTTTGVLL------------GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAV 3007
Query: 3748 H----PTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPD 3803
+ P L G +H VT + + L V + D N+ +++GG+PD
Sbjct: 3008 YDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3067
Query: 3804 YGAIPKAGLSSG--FIGCVRELRI 3825
+ + GL++ F GC+R L++
Sbjct: 3068 --DLKQFGLTTSIPFRGCIRSLKL 3089
Score = 33.9 bits (76), Expect = 3.7
Identities = 19/59 (32%), Positives = 22/59 (37%), Gaps = 11/59 (18%)
Query: 3868 VCVCPAGFTGSRCEHSQALH-----------CHPEACGPDATCVNRPDGRGYTCRCHLG 3915
VC CP G+TGS CE H C P C A + G C+ H G
Sbjct: 723 VCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTG 781
Score = 33.9 bits (76), Expect = 3.7
Identities = 35/123 (28%), Positives = 47/123 (38%), Gaps = 21/123 (17%)
Query: 4076 CVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGF 4135
C +V G+R D + G+ G+ PC C + E QC C+ G
Sbjct: 937 CECRANVQGQRCDKCKA--GTFGLQSARGCVPCN---CNSFGSKSFDCEESGQCWCQPGV 991
Query: 4136 KG---DLCEH-----EENPCQLREPCLH-GGTCQGT--RCLCLPGFSGPRCQQGS----G 4180
G D C H +E C E C H G C RC+C P G +C + + G
Sbjct: 992 TGKKCDRCAHGYFNFQEGGCTACE-CSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWG 1050
Query: 4181 HGI 4183
H I
Sbjct: 1051 HSI 1053
Score = 32.7 bits (73), Expect = 8.2
Identities = 24/89 (26%), Positives = 34/89 (38%), Gaps = 20/89 (22%)
Query: 4118 TCMPAGEYEFQCL-CRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRC------------ 4164
+C+ G +++C C G++G CE P P GG+CQ C
Sbjct: 1483 SCVAEGLDDYRCTACPRGYEGQYCERCA-PGYTGSPGNPGGSCQECECDPYGSLPVPCDP 1541
Query: 4165 -----LCLPGFSGPRCQQGSGHGIAESDW 4188
C PG +G +C G H A W
Sbjct: 1542 VTGFCTCRPGATGRKC-DGCKHWHAREGW 1569
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 358 bits (920), Expect = 5e-98
Identities = 214/567 (37%), Positives = 274/567 (48%), Gaps = 43/567 (7%)
Query: 1122 EVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHH 1181
E QC C PG G C C GY G C C C C+P+TG C C +
Sbjct: 981 ESGQCWCQPGVTGKKCDRCAHGYFNFQEG----GCTACECSHLGNNCDPKTGRCI-CPPN 1035
Query: 1182 TEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGH 1241
T G +C +C P +G + C+ C C G C ++T C+ C P
Sbjct: 1036 TIGEKCSKCAPNTWGHS---ITTGCKACNC---STVGSLDFQCNVNTG---QCN-CHPKF 1085
Query: 1242 SGRHCERCAPGYYGNPSQGQPCQR-DSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVE 1300
SG C C+ G++ P C D +PG CD + S D GQC CK VE
Sbjct: 1086 SGAKCTECSRGHWNYPR----CNLCDCFLPGTDATTCDSETKKCSCSDQTGQCTCKVNVE 1141
Query: 1301 GLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVN 1360
G+ C CRP F L A NP GC C+C G T QC+ + + LI T Q +
Sbjct: 1142 GIHCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEA---KGLIRTWVTLKAEQTILPLV 1198
Query: 1361 PQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLS 1420
+ T + V PE L E FYW+LPE ++G K+ AYGGKL+Y +
Sbjct: 1199 DEALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIY 1258
Query: 1421 YTAGPQ-GSPLSDPDVQITGNNI----MLVASQPALQGPERRSYEIMFREEFWRRPDGQP 1475
+ A + G +P V I G ++V A + +EI E+ W+ P
Sbjct: 1259 FEAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDP 1318
Query: 1476 -----ATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNR--PRALEVE 1528
TRE L L D+ +LI+AT+ + + IS +S+EVA+ G P A +E
Sbjct: 1319 RVHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIE 1378
Query: 1529 ECRCPPGYIGLSCQDCAPGYTRTGS-------GLYLGHCELCECNGHSDLCHPETGACSQ 1581
+C CP GY GLSC+ C PG+ R S G LG C C+CNGHS LC PET C
Sbjct: 1379 KCDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQN 1438
Query: 1582 CQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTAC 1641
CQH+ AG+FCE CA GYYG G P DCQ CACPL + N FS +C + G YRCTAC
Sbjct: 1439 CQHHTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTAC 1497
Query: 1642 EPGYTGQYCEQCGPGYVGNPSVQGGQC 1668
GY GQYCE+C PGY G+P GG C
Sbjct: 1498 PRGYEGQYCERCAPGYTGSPGNPGGSC 1524
Score = 331 bits (848), Expect = 1e-89
Identities = 199/590 (33%), Positives = 275/590 (46%), Gaps = 61/590 (10%)
Query: 1118 DPALEVEQCSCPPGYRGPSCQDCDTGYTRTP--SGLYLGT--CERCSCHGHSEACEPET- 1172
DPA +C C G SC C G+ + P +G +L CE C+CHG +E C +
Sbjct: 299 DPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYYDEN 358
Query: 1173 -----------------GACQGCQHHTEGPRCEQCQPGYYGD--AQRGTPQDCQLCPCYG 1213
G C C +T G CE C G++ P+ CQ PC+
Sbjct: 359 VARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQ--PCHC 416
Query: 1214 DPAAGQAAHTCFLDTDGH------PTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDS 1267
DP G C D + H P C G G C+RCA GY G P C+
Sbjct: 417 DPI-GSLNEVCVKD-EKHARRGLAPGSCHCKTGFGGVSCDRCARGYTGYPD----CK--- 467
Query: 1268 QVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
CNC GS ++ G C CK VEG CS C+ F+L N GC CFC
Sbjct: 468 ------ACNCSGLGS-KNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFC 520
Query: 1328 MGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNF 1387
G++ +C SS +T I D G+ L + R+ + P+ +S
Sbjct: 521 SGVSNRCQSSYWTYGKIQ------DMSGWYLTDLPGRIRVAPQQDDLDSPQQISISNAEA 574
Query: 1388 AQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLS---DPDVQITGNNIML 1444
Q S+YW P Y G+K+ A GG+L +T+SY + + + GN++ +
Sbjct: 575 RQALPHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSI 634
Query: 1445 VASQPA--LQGPERRSYEIMFREE-FWRRPDGQPATREHLLMALADLDELLIRATFS-SV 1500
+Q L E + ++ +EE F P R+ + LA+L +L++ T+S +
Sbjct: 635 STAQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGM 694
Query: 1501 PLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHC 1560
+S+V+LE A P++ A VE C+CPPGY G SC+ C P + R ++ G C
Sbjct: 695 DAIFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGIC 754
Query: 1561 ELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNP 1620
E C+C GH++ C TG C C+ + G +C+ C PG+YG+ T GT EDCQPCACPL P
Sbjct: 755 EPCQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIP 814
Query: 1621 ENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLP 1670
N FS TC + G C C GYTG CE+C GY G PSV GG C P
Sbjct: 815 SNNFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQP 864
Score = 327 bits (838), Expect = 2e-88
Identities = 203/613 (33%), Positives = 285/613 (46%), Gaps = 63/613 (10%)
Query: 730 ECRCPIGYSGLSCESC-DAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTE 788
+C C G +G C+ C +F GG C+ C C+ ++CDP G C+ C NT
Sbjct: 984 QCWCQPGVTGKKCDRCAHGYFNFQEGG-----CTACECSHLGNNCDPKTGRCI-CPPNTI 1037
Query: 789 GPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTG 848
G +C+KC +G ++ T C+ C C + + C ++T GQ C P ++G
Sbjct: 1038 GEKCSKCAPNTWGHSI---TTGCKACNCSTVGS---LDFQCNVNT-GQCNCH---PKFSG 1087
Query: 849 RRCESCAPGYEGNP-------IQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGR 901
+C C+ G+ P PG + E +C G C CK NV G
Sbjct: 1088 AKCTECSRGHWNYPRCNLCDCFLPGTDATTCDSETKKCSCSDQTGQ----CTCKVNVEGI 1143
Query: 902 LCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAAST 961
C+ C G F L +NP GC C+C G + C+ + E L + A
Sbjct: 1144 HCDRCRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQTILPLVDEALQ 1203
Query: 962 HTTNEGIFSPTPGELGFSSFHR--LLSGPYFWSLPSRFLGDKVTSYGGELRFTVTQRSQP 1019
HTT +GI P + R L P++W LP +F G K+ +YGG+L++ + ++
Sbjct: 1204 HTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYFEARE 1263
Query: 1020 GSTPLHGQPLVVLQGN-----NIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQP--- 1071
+ P V+++G II+ H A P GQ + + E+ W+ P
Sbjct: 1264 ETGFSTYNPQVIIRGGTPTHARIIVRHMAA--PLIGQLTRHEIEMTEKEWKYYGDDPRVH 1321
Query: 1072 --ATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEE--TGQDPALEVEQCS 1127
TRE L L I +LI+A+Y +SR+S ISM+VA T PA +E+C
Sbjct: 1322 RTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEKCD 1381
Query: 1128 CPPGYRGPSCQDCDTGYTRTPS-------GLYLGTCERCSCHGHSEACEPETGACQGCQH 1180
CP GY G SC+ C G+ R S G LGTC C C+GHS C+PET CQ CQH
Sbjct: 1382 CPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNCQH 1441
Query: 1181 HTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPG 1240
HT G CE+C GYYG +G P DCQ C C ++ + +C + C AC G
Sbjct: 1442 HTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACPRG 1500
Query: 1241 HSGRHCERCAPGYYGNP-SQGQPCQRDSQVPGPIGCNCDPQGSVSSQCD-AAGQCQCKAQ 1298
+ G++CERCAPGY G+P + G CQ C CDP GS+ CD G C C+
Sbjct: 1501 YEGQYCERCAPGYTGSPGNPGGSCQE---------CECDPYGSLPVPCDPVTGFCTCRPG 1551
Query: 1299 VEGLTCSHCRPHH 1311
G C C+ H
Sbjct: 1552 ATGRKCDGCKHWH 1564
Score = 323 bits (829), Expect = 2e-87
Identities = 210/695 (30%), Positives = 307/695 (44%), Gaps = 118/695 (16%)
Query: 725 AHSVEECRCPIGYSGLSCESCDAHFTRVP--GGPYLGT--CSGCNCNGHASSCDPVY--- 777
A + C C G SC+ C F + P G +L C CNC+G A C Y
Sbjct: 301 ATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEEC--YYDEN 358
Query: 778 -----------------GHCLNCQHNTEGPQCNKCKAGFFGDAMKAT--ATSCRPCPCPY 818
G C+NC NT G C C GFF + C+PC C
Sbjct: 359 VARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCHCDP 418
Query: 819 IDASRRFSDTCFLDTD------GQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPV 872
I + ++ C D +C C G+ G C+ CA GY G P C+
Sbjct: 419 IGS---LNEVCVKDEKHARRGLAPGSCH-CKTGFGGVSCDRCARGYTGYP-----DCKAC 469
Query: 873 NQEIVRCDERGSMGTSG--EACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVS 930
N C GS C CK NV G C+ C G F+L N GC +CFC GVS
Sbjct: 470 N-----CSGLGSKNEDPCFGPCICKENVEGGDCSRCKSGFFNLQEDNWKGCDECFCSGVS 524
Query: 931 RHCTSSSWSRAQLHGAS-----EEPGHFSLTNAASTHTTNEGIFSPTPGELGFSSFHRLL 985
C SS W+ ++ S + PG + + + SP + + + L
Sbjct: 525 NRCQSSYWTYGKIQDMSGWYLTDLPGRIRVA------PQQDDLDSPQQISISNAEARQAL 578
Query: 986 SGPYFWSLPSRFLGDKVTSYGGELRFTVTQ--RSQPGSTPLHGQPLVVLQGNNIILEHHV 1043
Y+WS P+ +LG+K+ + GG+L FT++ + T Q +++L+GN++ +
Sbjct: 579 PHSYYWSAPAPYLGNKLPAVGGQLTFTISYDLEEEEEDTERVLQLMIILEGNDLSIS--T 636
Query: 1044 AQEP---SPGQPSTFIVPFREQAWQRPDGQ-PATREHLLMALAGIDTLLIRASYA-QQPA 1098
AQ+ P + T ++ +E+++ P R+ + LA + +L++ +Y+ A
Sbjct: 637 AQDEVYLHPSEEHTNVLLLKEESFTIHGTHFPVRRKEFMTVLANLKRVLLQITYSFGMDA 696
Query: 1099 ESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCER 1158
R+S ++++ AV T A VE C CPPGY G SC+ C + R ++ G CE
Sbjct: 697 IFRLSSVNLESAVSYPTDGSIAAAVEVCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEP 756
Query: 1159 CSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAG 1218
C C GH+E+C+ TG C C+ HT GP C++C PG+YG+ +GT +DCQ C C + +
Sbjct: 757 CQCFGHAESCDDVTGECLNCKDHTGGPYCDKCLPGFYGEPTKGTSEDCQPCACPLNIPSN 816
Query: 1219 QAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPS----QGQPCQRDSQV----- 1269
+ TC LD CD C G++G CERCA GY+G PS QPCQ + +
Sbjct: 817 NFSPTCHLDRSLGLICDGCPVGYTGPRCERCAEGYFGQPSVPGGSCQPCQCNDNLDFSIP 876
Query: 1270 --------------PGPIG----------------------CNCDPQGSVSSQCDA-AGQ 1292
PG G C C+ GS S C + GQ
Sbjct: 877 GSCDSLSGSCLICKPGTTGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQ 936
Query: 1293 CQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
C+C+A V+G C C+ F L ++ GC+PC C
Sbjct: 937 CECRANVQGQRCDKCKAGTFGLQSAR--GCVPCNC 969
Score = 252 bits (643), Expect = 7e-66
Identities = 153/435 (35%), Positives = 214/435 (49%), Gaps = 27/435 (6%)
Query: 505 CPDGHFYLEHS--AACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPG 562
C G F L+ C CFC G+++ CQS+ +I+ D G +T PG
Sbjct: 500 CKSGFFNLQEDNWKGCDECFCSGVSNRCQSSYWTYGKIQ-------DMSGWYLT--DLPG 550
Query: 563 TPPLSSTQLQIDPSLHEFQLVDLS----RRFLVHDSFWALPEQFLGNKVDSYGGSLRYNV 618
++ Q +D Q + +S R+ L H +W+ P +LGNK+ + GG L + +
Sbjct: 551 RIRVAPQQDDLDSP----QQISISNAEARQALPHSYYWSAPAPYLGNKLPAVGGQLTFTI 606
Query: 619 RYELARGM--LEPVQRPDVVLMGAGYRL-LSRGHTPTQPGALNQRQVQFSEEHW-VHESG 674
Y+L E V + ++L G + ++ P + + EE + +H +
Sbjct: 607 SYDLEEEEEDTERVLQLMIILEGNDLSISTAQDEVYLHPSEEHTNVLLLKEESFTIHGTH 666
Query: 675 RPVQRAELLQVLQSLEAVLIQTVYNTKMASV-GLSDIAMDTTVTHATSHGRAHSVEECRC 733
PV+R E + VL +L+ VL+Q Y+ M ++ LS + +++ V++ T A +VE C+C
Sbjct: 667 FPVRRKEFMTVLANLKRVLLQITYSFGMDAIFRLSSVNLESAVSYPTDGSIAAAVEVCQC 726
Query: 734 PIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCN 793
P GY+G SCESC RV G + G C C C GHA SCD V G CLNC+ +T GP C+
Sbjct: 727 PPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTGGPYCD 786
Query: 794 KCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCES 853
KC GF+G+ K T+ C+PC CP S FS TC LD CD C GYTG RCE
Sbjct: 787 KCLPGFYGEPTKGTSEDCQPCACPLNIPSNNFSPTCHLDRSLGLICDGCPVGYTGPRCER 846
Query: 854 CAPGYEGNPIQPGGKCRP--VNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSF 911
CA GY G P PGG C+P N + SG CK GR C CADG F
Sbjct: 847 CAEGYFGQPSVPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGTTGRYCELCADGYF 906
Query: 912 HLSTRNPDGCLKCFC 926
+ C C C
Sbjct: 907 G-DAVDAKNCQPCRC 920
Score = 232 bits (592), Expect = 5e-60
Identities = 145/445 (32%), Positives = 207/445 (46%), Gaps = 43/445 (9%)
Query: 505 CPDGHFYLE--HSAACLPCFCFGITSVCQSTRRF-RDQIRLRFDQPDDFKGVNVTMPAQP 561
C G F L+ + C C+CFG T+ C + R + L+ +Q +P
Sbjct: 1148 CRPGKFGLDAKNPLGCSSCYCFGTTTQCSEAKGLIRTWVTLKAEQ--------TILPLVD 1199
Query: 562 GTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSF-WALPEQFLGNKVDSYGGSLRYNVRY 620
++T+ + +DL R L + F W LPEQF G K+ +YGG L+Y + +
Sbjct: 1200 EALQHTTTKGIVFQHPEIVAHMDLMREDLHLEPFYWKLPEQFEGKKLMAYGGKLKYAIYF 1259
Query: 621 ELARGMLEPVQRPDVVLMGAG---YRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGRP- 676
E P V++ G R++ R G L + +++ +E+ W + P
Sbjct: 1260 EAREETGFSTYNPQVIIRGGTPTHARIIVRHMAAPLIGQLTRHEIEMTEKEWKYYGDDPR 1319
Query: 677 ----VQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTH--ATSHGRAHSVEE 730
V R + L +L + +LI+ Y M +S+I+M+ T A +E+
Sbjct: 1320 VHRTVTREDFLDILYDIHYILIKATYGNFMRQSRISEISMEVAEQGRGTTMTPPADLIEK 1379
Query: 731 CRCPIGYSGLSCESCDAHFTRV---PGG----PYLGTCSGCNCNGHASSCDPVYGHCLNC 783
C CP+GYSGLSCE+C F R+ PGG P LGTC C CNGH+S CDP C NC
Sbjct: 1380 CDCPLGYSGLSCEACLPGFYRLRSQPGGRTPGPTLGTCVPCQCNGHSSLCDPETSICQNC 1439
Query: 784 QHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACA 843
QH+T G C +C G++G +K C+ C CP I +S FS +C + C AC
Sbjct: 1440 QHHTAGDFCERCALGYYG-IVKGLPNDCQQCACPLISSSNNFSPSCVAEGLDDYRCTACP 1498
Query: 844 PGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEA----CRCKNNVV 899
GY G+ CE CAPGY G+P PGG C+ CD GS+ + C C+
Sbjct: 1499 RGYEGQYCERCAPGYTGSPGNPGGSCQE-----CECDPYGSLPVPCDPVTGFCTCRPGAT 1553
Query: 900 GRLCNECADGSFHLSTRNPDGCLKC 924
GR C DG H R C+ C
Sbjct: 1554 GRKC----DGCKHWHAREGWECVFC 1574
Score = 93.6 bits (231), Expect = 4e-18
Identities = 54/144 (37%), Positives = 71/144 (49%), Gaps = 17/144 (11%)
Query: 1532 CPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL-----CHPETGACSQCQHNA 1586
CP GY G C+ CA GY S + G C+ C+CN + D C +G+C C+
Sbjct: 835 CPVGYTGPRCERCAEGYFGQPS-VPGGSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGT 893
Query: 1587 AGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYT 1646
G +CELCA GY+GDA ++CQPC C N FS C S +C C
Sbjct: 894 TGRYCELCADGYFGDAV--DAKNCQPCRC---NAGGSFSEVCHSQTG---QC-ECRANVQ 944
Query: 1647 GQYCEQCGPGYVGNPSVQGGQCLP 1670
GQ C++C G G S +G C+P
Sbjct: 945 GQRCDKCKAGTFGLQSARG--CVP 966
Score = 85.9 bits (211), Expect = 8e-16
Identities = 70/256 (27%), Positives = 93/256 (36%), Gaps = 84/256 (32%)
Query: 733 CPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHAS-----SCDPVYGHCL------ 781
CP+GY+G CE C + P P G+C C CN + SCD + G CL
Sbjct: 835 CPVGYTGPRCERCAEGYFGQPSVPG-GSCQPCQCNDNLDFSIPGSCDSLSGSCLICKPGT 893
Query: 782 --------------------------------------------NCQHNTEGPQCNKCKA 797
C+ N +G +C+KCKA
Sbjct: 894 TGRYCELCADGYFGDAVDAKNCQPCRCNAGGSFSEVCHSQTGQCECRANVQGQRCDKCKA 953
Query: 798 GFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPG 857
G FG +A C PC C F F D + C C PG TG++C+ CA G
Sbjct: 954 GTFG---LQSARGCVPCNC------NSFGSKSF-DCEESGQC-WCQPGVTGKKCDRCAHG 1002
Query: 858 YEGNPIQPGG----KCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHL 913
Y Q GG +C + CD + C C N +G C++CA ++
Sbjct: 1003 YFN--FQEGGCTACECSHLGN---NCDPKTG------RCICPPNTIGEKCSKCAPNTWGH 1051
Query: 914 STRNPDGCLKCFCMGV 929
S GC C C V
Sbjct: 1052 SITT--GCKACNCSTV 1065
Score = 85.9 bits (211), Expect = 8e-16
Identities = 59/162 (36%), Positives = 82/162 (50%), Gaps = 13/162 (8%)
Query: 4229 TIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPI 4288
TIELEVRT SGLL + + A DF ++ L++G F Y LGSG+ + I
Sbjct: 2788 TIELEVRTEAESGLLFYMA-RINHA----DFATVQLRNGLPYFSYDLGSGDTHTMIPTKI 2842
Query: 4289 NDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVA--VNAKGSVYIGGAP-DVATLTG 4345
NDG+WH++ +R + G + VDG S R+ P A ++ G +Y+GG P + T
Sbjct: 2843 NDGQWHKIKIMRSKQEGILYVDG---ASNRTISPKKADILDVVGMLYVGGLPINYTTRRI 2899
Query: 4346 GRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQAGANTR 4387
G + I GCV+N LH A A QP H AN +
Sbjct: 2900 GPVTYSIDGCVRN--LHMAEAPADLEQPTSSFHVGTCFANAQ 2939
Score = 66.6 bits (161), Expect = 5e-10
Identities = 53/169 (31%), Positives = 80/169 (47%), Gaps = 16/169 (9%)
Query: 4198 APGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGK 4257
A Q G YF GF G F L + +E E RT+T +G+LL G + Q
Sbjct: 2936 ANAQRGTYFDGTGFAKAVGG-FKVGLDLL---VEFEFRTTTTTGVLL------GISSQKM 2985
Query: 4258 DFISLGLQDGHLVFRYQLGSGEARLVSEDPIN----DGEWHRVTALREGRRGSIQVDGEE 4313
D + + + D L+F G+G V + + DG+WH+VTA + R + VDG +
Sbjct: 2986 DGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQ 3045
Query: 4314 LVSGRSPGP-NVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361
V +SP P + + + V++GG PD G S GC+++L L
Sbjct: 3046 -VEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKL 3093
Score = 62.8 bits (151), Expect = 7e-09
Identities = 45/148 (30%), Positives = 73/148 (49%), Gaps = 17/148 (11%)
Query: 4209 DGFLAFPGHVF---SRSLPEVPE--TIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLG 4263
+G + F G + SR + P T+ + RT ++S LL++ +DF+S+
Sbjct: 2338 EGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSALLMYLATR-----DLRDFMSVE 2392
Query: 4264 LQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQV-----DGEELVSGR 4318
L DGH+ Y LGSG A +VS NDG+W T R ++ +I + + EE ++
Sbjct: 2393 LTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATS 2452
Query: 4319 SPGPNVAVNAKG--SVYIGGAPDVATLT 4344
S G N ++ K +Y GG P + L+
Sbjct: 2453 SSGNNFGLDLKADDKIYFGGLPTLRNLS 2480
Score = 51.6 bits (122), Expect = 2e-05
Identities = 33/139 (23%), Positives = 69/139 (49%), Gaps = 14/139 (10%)
Query: 3956 EFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHR 4015
+F+ + +L++ + + DF+S+ + GH++ Y+LGSG+A + S + G+W
Sbjct: 2367 KFRTFSSSALLMYLATRD--LRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKS 2424
Query: 4016 VSAERLNKDGSLRV-----NGGRPVLRSSPGKSQGLNLHT--LLYLGGVEP----SVPLS 4064
+ R+ K ++ + N + SS G + GL+L +Y GG+ S+
Sbjct: 2425 FTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFGGLPTLRNLSMKAR 2484
Query: 4065 PATNMSAHFRGCVGEVSVN 4083
P N+ + GC+ ++ ++
Sbjct: 2485 PEVNLK-KYSGCLKDIEIS 2502
Score = 50.4 bits (119), Expect = 4e-05
Identities = 41/142 (28%), Positives = 62/142 (43%), Gaps = 13/142 (9%)
Query: 3685 KFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMA 3744
+ I++ R ++ G+L Y + DF + L G P F +D GSG
Sbjct: 2786 RLTIELEVRTEAESGLLFYMARIN-----------HADFATVQLRNGLPYFSYDLGSGDT 2834
Query: 3745 TIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYP-D 3803
PT + G +H + ++RS +G L V D A S K LD+ LY+GG P +
Sbjct: 2835 HTMIPTKINDGQWHKIKIMRSKQEGILYV-DGASNRTISPKKADILDVVGMLYVGGLPIN 2893
Query: 3804 YGAIPKAGLSSGFIGCVRELRI 3825
Y ++ GCVR L +
Sbjct: 2894 YTTRRIGPVTYSIDGCVRNLHM 2915
Score = 48.9 bits (115), Expect = 1e-04
Identities = 36/119 (30%), Positives = 61/119 (51%), Gaps = 17/119 (14%)
Query: 4230 IELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSED-PI 4288
I + V+T+ A LL + G + + DF+++ ++ G + F + +GSG R+ D I
Sbjct: 2170 IVVNVKTAVADNLLFYLG-----SAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTI 2224
Query: 4289 NDGEWHRVTALREGRRGSIQV---DGEELV-------SGRSPGPNVA-VNAKGSVYIGG 4336
+D W+R+ A R GR G+I V DG + S PG + V+A +++GG
Sbjct: 2225 DDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGG 2283
Score = 48.1 bits (113), Expect = 2e-04
Identities = 39/159 (24%), Positives = 71/159 (44%), Gaps = 4/159 (2%)
Query: 3945 TNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRS 4004
T + L +++E + A G+L + + DF ++ + G F Y+LGSG
Sbjct: 2781 TKVKNRLTIELEVRTEAESGLLFYMARINHA--DFATVQLRNGLPYFSYDLGSGDTHTMI 2838
Query: 4005 AEPLALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLS 4064
+ G+WH++ R ++G L V+G SP K+ L++ +LY+GG+ +
Sbjct: 2839 PTKINDGQWHKIKIMRSKQEGILYVDGASN-RTISPKKADILDVVGMLYVGGLPINYTTR 2897
Query: 4065 PATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCY 4103
++ GCV + + DL S +G C+
Sbjct: 2898 RIGPVTYSIDGCVRNLHMAEAPADLEQP-TSSFHVGTCF 2935
Score = 47.4 bits (111), Expect = 3e-04
Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 11/150 (7%)
Query: 3950 ELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSG--LAVLRSAEP 4007
+L ++ EF+ GVLL G S D + + M+ L F + G+G AV + P
Sbjct: 2961 DLLVEFEFRTTTTTGVLL---GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAVYDAGVP 3017
Query: 4008 --LALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSP 4065
L G+WH+V+A ++ L V+G + +S S + + +++GG +
Sbjct: 3018 GHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFG 3077
Query: 4066 ATNMSAHFRGCVGEVSV---NGKRLDLTYS 4092
T S FRGC+ + + GK L++ ++
Sbjct: 3078 LTT-SIPFRGCIRSLKLTKGTGKPLEVNFA 3106
Score = 43.1 bits (100), Expect = 0.006
Identities = 41/151 (27%), Positives = 68/151 (45%), Gaps = 26/151 (17%)
Query: 3688 IKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ-PDFISFGLVGGRPEFRFDAGSGMATI 3746
+ FR S+ +L+Y LA R DF+S L G + +D GSGMA++
Sbjct: 2364 VMFKFRTFSSSALLMY------------LATRDLRDFMSVELTDGHIKVSYDLGSGMASV 2411
Query: 3747 RHPTPLALGHFHTVTLLRSLTQGSLIVGDL-----APVNGTSQGKFQGLDL--NEELYLG 3799
G + + TL R Q ++ + D+ + +S G GLDL ++++Y G
Sbjct: 2412 VSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADDKIYFG 2471
Query: 3800 GYP-----DYGAIPKAGLSSGFIGCVRELRI 3825
G P A P+ L + GC++++ I
Sbjct: 2472 GLPTLRNLSMKARPEVNLKK-YSGCLKDIEI 2501
Score = 42.7 bits (99), Expect = 0.008
Identities = 37/156 (23%), Positives = 76/156 (48%), Gaps = 16/156 (10%)
Query: 3955 VEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAE-PLALGRW 4013
V K D +L + G S DF+++ M G + F +++GSG+ + + + W
Sbjct: 2172 VNVKTAVADNLLFYLG--SAKFIDFLAIEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYW 2229
Query: 4014 HRVSAERLNKDGSLRV---NGGRPVL-------RSSPGKS-QGLNLHTLLYLGGVEPSVP 4062
+R+ A R ++G++ V +G + + S PG + ++ + +L++GG+ +
Sbjct: 2230 YRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTGKLK 2289
Query: 4063 LSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQG 4098
+ A + F GC+GE + K + L ++F +G
Sbjct: 2290 KADAVRVIT-FTGCMGETYFDNKPIGL-WNFREKEG 2323
Score = 39.7 bits (91), Expect = 0.067
Identities = 31/121 (25%), Positives = 36/121 (29%), Gaps = 23/121 (19%)
Query: 829 CFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRC--------- 879
C LD + C G C+ C PG+ P + G E C
Sbjct: 296 CPLDPATNKSRCECEHNTCGDSCDQCCPGFHQKPWRAGTFLTKTECEACNCHGKAEECYY 355
Query: 880 DE-----------RGSMGTSGEACRCKNNVVGRLCNECADGSFH---LSTRNPDGCLKCF 925
DE RG G C N G C C DG F +S P C C
Sbjct: 356 DENVARRNLSLNIRGKYIGGGVCINCTQNTAGINCETCTDGFFRPKGVSPNYPRPCQPCH 415
Query: 926 C 926
C
Sbjct: 416 C 416
Score = 35.4 bits (80), Expect = 1.3
Identities = 32/144 (22%), Positives = 63/144 (43%), Gaps = 20/144 (13%)
Query: 3688 IKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIR 3747
++ FR + G+LL +++++ D + ++ + F D G+G T
Sbjct: 2964 VEFEFRTTTTTGVLL------------GISSQKMDGMGIEMIDEKLMFHVDNGAGRFTAV 3011
Query: 3748 H----PTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPD 3803
+ P L G +H VT + + L V + D N+ +++GG+PD
Sbjct: 3012 YDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPD 3071
Query: 3804 YGAIPKAGLSSG--FIGCVRELRI 3825
+ + GL++ F GC+R L++
Sbjct: 3072 --DLKQFGLTTSIPFRGCIRSLKL 3093
Score = 33.9 bits (76), Expect = 3.7
Identities = 19/59 (32%), Positives = 22/59 (37%), Gaps = 11/59 (18%)
Query: 3868 VCVCPAGFTGSRCEHSQALH-----------CHPEACGPDATCVNRPDGRGYTCRCHLG 3915
VC CP G+TGS CE H C P C A + G C+ H G
Sbjct: 723 VCQCPPGYTGSSCESCWPRHRRVNGTIFGGICEPCQCFGHAESCDDVTGECLNCKDHTG 781
Score = 33.9 bits (76), Expect = 3.7
Identities = 35/123 (28%), Positives = 47/123 (38%), Gaps = 21/123 (17%)
Query: 4076 CVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGF 4135
C +V G+R D + G+ G+ PC C + E QC C+ G
Sbjct: 937 CECRANVQGQRCDKCKA--GTFGLQSARGCVPCN---CNSFGSKSFDCEESGQCWCQPGV 991
Query: 4136 KG---DLCEH-----EENPCQLREPCLH-GGTCQGT--RCLCLPGFSGPRCQQGS----G 4180
G D C H +E C E C H G C RC+C P G +C + + G
Sbjct: 992 TGKKCDRCAHGYFNFQEGGCTACE-CSHLGNNCDPKTGRCICPPNTIGEKCSKCAPNTWG 1050
Query: 4181 HGI 4183
H I
Sbjct: 1051 HSI 1053
Score = 32.7 bits (73), Expect = 8.2
Identities = 24/89 (26%), Positives = 34/89 (38%), Gaps = 20/89 (22%)
Query: 4118 TCMPAGEYEFQCL-CRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRC------------ 4164
+C+ G +++C C G++G CE P P GG+CQ C
Sbjct: 1483 SCVAEGLDDYRCTACPRGYEGQYCERCA-PGYTGSPGNPGGSCQECECDPYGSLPVPCDP 1541
Query: 4165 -----LCLPGFSGPRCQQGSGHGIAESDW 4188
C PG +G +C G H A W
Sbjct: 1542 VTGFCTCRPGATGRKC-DGCKHWHAREGW 1569
>gi|38788416 laminin, alpha 1 precursor [Homo sapiens]
Length = 3075
Score = 353 bits (905), Expect = 3e-96
Identities = 207/570 (36%), Positives = 280/570 (49%), Gaps = 43/570 (7%)
Query: 1118 DPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQG 1177
D + QC C PG G C C G+ G +C C C C+PETG C
Sbjct: 961 DGCTDEGQCHCVPGVAGKRCDRCAHGFYAYQDG----SCTPCDCPHTQNTCDPETGECV- 1015
Query: 1178 CQHHTEGPRCEQCQPGYYG-DAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDA 1236
C HT+G +CE+C+ G++G DA+ G CQ C C G H C + T GH C
Sbjct: 1016 CPPHTQGVKCEECEDGHWGYDAEVG----CQACNC---SLVGSTHHRCDVVT-GH--CQ- 1064
Query: 1237 CSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCK 1296
C GR C++C+ GY P PC D + G G C+ + + + G C CK
Sbjct: 1065 CKSKFGGRACDQCSLGYRDFPDC-VPC--DCDLRGTSGDACNLEQGLCGCVEETGACPCK 1121
Query: 1297 AQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGF 1356
V G C+ CR F L A NP GC PCFC G++ C+ + T G Q
Sbjct: 1122 ENVFGPQCNECREGTFALRADNPLGCSPCFCSGLSHLCSE---LEDYVRTPVTLGSDQPL 1178
Query: 1357 ALVNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLR 1416
V Q N R T E P+ + + E FYW+LP+ +QGD++ AYGGKL+
Sbjct: 1179 LRVVSQSNLRGTTEGVYYQAPDFLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGGKLK 1238
Query: 1417 YTLS-YTAGPQGSPLSDPDVQITGNNI---MLVASQPALQGPERRSYEIMFREEFWRRPD 1472
Y+++ Y+ G+ +P V I G I ++ PA + R+ E+ RE FW+ +
Sbjct: 1239 YSVAFYSLDGVGTSNFEPQVLIKGGRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFN 1298
Query: 1473 G---QPATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNRPR---ALE 1526
+P TRE + L+D++ +LI+A++ + IS +S+EV + P A
Sbjct: 1299 SVSEKPVTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEKLHPEEEVASL 1358
Query: 1527 VEECRCPPGYIGLSCQDCAPGYTR--------TGSGLYLGHCELCECNGHSDLCHPETGA 1578
+E C CPPG +G SCQDCAPGY R G + C C CN HSD C P TG
Sbjct: 1359 LENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGK 1418
Query: 1579 CSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRC 1638
C C N AG+ C++C GYYG T G+ DC CACP + P + FS TC G +RC
Sbjct: 1419 CLNCGDNTAGDHCDVCTSGYYGKVT-GSASDCALCACPHSPPAS-FSPTCVLEGDHDFRC 1476
Query: 1639 TACEPGYTGQYCEQCGPGYVGNPSVQGGQC 1668
AC GY G++CE+C Y GNP GG C
Sbjct: 1477 DACLLGYEGKHCERCSSSYYGNPQTPGGSC 1506
Score = 347 bits (891), Expect = 1e-94
Identities = 215/638 (33%), Positives = 311/638 (48%), Gaps = 79/638 (12%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEG 789
+C C G +G C+ C F G +C+ C+C ++CDP G C+ C +T+G
Sbjct: 968 QCHCVPGVAGKRCDRCAHGFYAYQDG----SCTPCDCPHTQNTCDPETGECV-CPPHTQG 1022
Query: 790 PQCNKCKAGFFG-DAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTG 848
+C +C+ G +G DA C+ C C + ++ D G C + + G
Sbjct: 1023 VKCEECEDGHWGYDA----EVGCQACNCSLVGSTHHRCDV----VTGHCQCKS---KFGG 1071
Query: 849 RRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGE-------------ACRCK 895
R C+ C+ GY P C P + CD RG+ G + AC CK
Sbjct: 1072 RACDQCSLGYRDFP-----DCVPCD-----CDLRGTSGDACNLEQGLCGCVEETGACPCK 1121
Query: 896 NNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTS-SSWSRAQLHGASEEPGHFS 954
NV G CNEC +G+F L NP GC CFC G+S C+ + R + S++P
Sbjct: 1122 ENVFGPQCNECREGTFALRADNPLGCSPCFCSGLSHLCSELEDYVRTPVTLGSDQP-LLR 1180
Query: 955 LTNAASTHTTNEGIFSPTPGELGFSSFHR--LLSGPYFWSLPSRFLGDKVTSYGGELRFT 1012
+ + ++ T EG++ P L ++ R + + P++W LP +F GD++ +YGG+L+++
Sbjct: 1181 VVSQSNLRGTTEGVYYQAPDFLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGGKLKYS 1240
Query: 1013 VTQRSQPGSTPLHGQPLVVLQGNNIILEHHVAQEPSP--GQPSTFIVPFREQAWQ---RP 1067
V S G + +P V+++G I + P+P G V RE W+
Sbjct: 1241 VAFYSLDGVGTSNFEPQVLIKGGRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYFNSV 1300
Query: 1068 DGQPATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEE---TGQDPALEVE 1124
+P TRE + L+ I+ +LI+ASY Q +SR+S ISM+V E ++ A +E
Sbjct: 1301 SEKPVTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEKLHPEEEVASLLE 1360
Query: 1125 QCSCPPGYRGPSCQDCDTGYTR--TPSGLYLG------TCERCSCHGHSEACEPETGACQ 1176
C CPPG G SCQDC GY R P+G G C CSC+ HS+ C+P TG C
Sbjct: 1361 NCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTGKCL 1420
Query: 1177 GCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDA 1236
C +T G C+ C GYYG G+ DC LC C P A + TC L+ D CDA
Sbjct: 1421 NCGDNTAGDHCDVCTSGYYGKV-TGSASDCALCACPHSPPA-SFSPTCVLEGDHDFRCDA 1478
Query: 1237 CSPGHSGRHCERCAPGYYGNP-SQGQPCQRDSQVPGPIGCNCDPQGSVSSQCD-AAGQCQ 1294
C G+ G+HCERC+ YYGNP + G CQ+ C+C+P GSV CD +GQC
Sbjct: 1479 CLLGYEGKHCERCSSSYYGNPQTPGGSCQK---------CDCNPHGSVHGDCDRTSGQCV 1529
Query: 1295 CKAQVEGLTCSHCRPHHFHLSASNPDGCLPC--FCMGI 1330
C+ GL C C P H + C+ C C+G+
Sbjct: 1530 CRLGASGLRCDECEPRHILMETD----CVSCDDECVGV 1563
Score = 333 bits (854), Expect = 2e-90
Identities = 201/594 (33%), Positives = 274/594 (46%), Gaps = 82/594 (13%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTP-------SGLYLGTCERCSCHGHSEACEPET----- 1172
QC C G SC C GY + P SG TCE C+CH ++ C +
Sbjct: 289 QCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSG---NTCEACNCHNKAKDCYYDESVAKQ 345
Query: 1173 -------------GACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQ 1219
G C C +T G CE C GYY + +D PC DP G
Sbjct: 346 KKSLNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNCDPV-GS 404
Query: 1220 AAHTCFLD---TDGH----PTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGP 1272
+ C D +D H P C G++G C+RC GY P+ C
Sbjct: 405 LSSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYKDYPT----C--------- 451
Query: 1273 IGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQ 1332
+ C C+P GS S + G C CK VEG C C+P ++L NP GC CFC G++
Sbjct: 452 VSCGCNPVGSASDE-PCTGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFCFGVSD 510
Query: 1333 QCASSAYTRHLISTHFAPGDFQGFALVN-------PQRNSRLTGEFTVEPVPEGAQLSFG 1385
C+S ++ +++ G+ + + P + L G Q+S
Sbjct: 511 VCSSLSWPVGQVNS------MSGWLVTDLISPRKIPSQQDALGGRH---------QVSIN 555
Query: 1386 NFAQLGH--ESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQ---GSPLSDPDVQITGN 1440
N A + +YW PE Y G+K+ A+GG L+YT+SY + + +S DV I GN
Sbjct: 556 NTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLKYTVSYDIPVETVDSNLMSHADVIIKGN 615
Query: 1441 NIMLVASQPALQGPERRSYEIMFR---EEFWRRPDGQPATREHLLMALADLDELLIRATF 1497
+ L L Y + R E F + R+ L+ LA++ LLIRA +
Sbjct: 616 GLTLSTQAEGLSLQPYEEYLNVVRLVPENFQDFHSKRQIDRDQLMTVLANVTHLLIRANY 675
Query: 1498 SSVPLAA-SISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLY 1556
+S +A + +VSL++A + A +VE C CP GY G SC+ C GY R L+
Sbjct: 676 NSAKMALYRLESVSLDIASSNAIDLVVAADVEHCECPQGYTGTSCESCLSGYYRVDGILF 735
Query: 1557 LGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACP 1616
G C+ CEC+GH+ C+ G C C HN G CE C PG+YG+ + GTP DCQPCACP
Sbjct: 736 GGICQPCECHGHAAECNVH-GVCIACAHNTTGVHCEQCLPGFYGEPSRGTPGDCQPCACP 794
Query: 1617 LTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLP 1670
LT N FS TC C C PGY+G +CE+C GY GNP+V G C+P
Sbjct: 795 LTIASNNFSPTCHLNDGDEVVCDWCAPGYSGAWCERCADGYYGNPTVPGESCVP 848
Score = 319 bits (818), Expect = 3e-86
Identities = 204/640 (31%), Positives = 290/640 (45%), Gaps = 66/640 (10%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYL----GTCSGCNCNGHASSC---DPVY----- 777
+C+C G SC C + + P P TC CNC+ A C + V
Sbjct: 289 QCQCEHNTCGESCNRCCPGYHQQPWRPGTVSSGNTCEACNCHNKAKDCYYDESVAKQKKS 348
Query: 778 ----------GHCLNCQHNTEGPQCNKCKAGFFGDAMKATATS--CRPCPCPYIDASRRF 825
G C+NC NT G C C G++ + CRPC C D
Sbjct: 349 LNTAGQFRGGGVCINCLQNTMGINCETCIDGYYRPHKVSPYEDEPCRPCNC---DPVGSL 405
Query: 826 SDTCFLD-------TDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVR 878
S C D Q C GYTG +C+ C GY+ P C PV
Sbjct: 406 SSVCIKDDLHSDLHNGKQPGQCPCKEGYTGEKCDRCQLGYKDYPTCVSCGCNPVGS---- 461
Query: 879 CDERGSMGTSGEACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSW 938
S C CK NV G+ C+ C G ++L +NP GC +CFC GVS C+S SW
Sbjct: 462 ----ASDEPCTGPCVCKENVEGKACDRCKPGFYNLKEKNPRGCSECFCFGVSDVCSSLSW 517
Query: 939 SRAQLHGASEEPGHFSLTNAASTH---TTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPS 995
Q++ S + +T+ S + + + + ++ + L+ Y+W+ P
Sbjct: 518 PVGQVNSMSG----WLVTDLISPRKIPSQQDALGGRHQVSINNTAVMQRLAPKYYWAAPE 573
Query: 996 RFLGDKVTSYGGELRFTVTQRS--QPGSTPLHGQPLVVLQGNNIILEHHV-AQEPSPGQP 1052
+LG+K+T++GG L++TV+ + + L V+++GN + L P +
Sbjct: 574 AYLGNKLTAFGGFLKYTVSYDIPVETVDSNLMSHADVIIKGNGLTLSTQAEGLSLQPYEE 633
Query: 1053 STFIVPFREQAWQR-PDGQPATREHLLMALAGIDTLLIRASY-AQQPAESRVSGISMDVA 1110
+V + +Q + R+ L+ LA + LLIRA+Y + + A R+ +S+D+A
Sbjct: 634 YLNVVRLVPENFQDFHSKRQIDRDQLMTVLANVTHLLIRANYNSAKMALYRLESVSLDIA 693
Query: 1111 VPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEP 1170
A +VE C CP GY G SC+ C +GY R L+ G C+ C CHGH+ C
Sbjct: 694 SSNAIDLVVAADVEHCECPQGYTGTSCESCLSGYYRVDGILFGGICQPCECHGHAAECNV 753
Query: 1171 ETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDG 1230
G C C H+T G CEQC PG+YG+ RGTP DCQ C C A+ + TC L+
Sbjct: 754 H-GVCIACAHNTTGVHCEQCLPGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGD 812
Query: 1231 HPTCDACSPGHSGRHCERCAPGYYGNPS-QGQPCQRDSQVPGPIGCNCDPQGSVSSQCDA 1289
CD C+PG+SG CERCA GYYGNP+ G+ C VP N DP S + CD+
Sbjct: 813 EVVCDWCAPGYSGAWCERCADGYYGNPTVPGESC-----VPCDCSGNVDP--SEAGHCDS 865
Query: 1290 -AGQC-QCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
G+C +C +G C C F+ A C C C
Sbjct: 866 VTGECLKCLGNTDGAHCERC-ADGFYGDAVTAKNCRACEC 904
Score = 246 bits (629), Expect = 3e-64
Identities = 149/437 (34%), Positives = 212/437 (48%), Gaps = 32/437 (7%)
Query: 505 CPDGHFYLEHS--AACLPCFCFGITSVCQSTRRFRDQIRLRFDQPDDFKGVNVTMPAQPG 562
C G + L+ C CFCFG++ VC S + Q + G VT P
Sbjct: 485 CKPGFYNLKEKNPRGCSECFCFGVSDVCSS-------LSWPVGQVNSMSGWLVTDLISPR 537
Query: 563 TPPLSSTQLQIDPSLHEFQLVDLS-RRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRYE 621
P L H+ + + + + L +WA PE +LGNK+ ++GG L+Y V Y+
Sbjct: 538 KIPSQQDALG---GRHQVSINNTAVMQRLAPKYYWAAPEAYLGNKLTAFGGFLKYTVSYD 594
Query: 622 LARGMLEP--VQRPDVVLMGAGYRLLSRGH-TPTQPGALNQRQVQFSEEHWVH-ESGRPV 677
+ ++ + DV++ G G L ++ QP V+ E++ S R +
Sbjct: 595 IPVETVDSNLMSHADVIIKGNGLTLSTQAEGLSLQPYEEYLNVVRLVPENFQDFHSKRQI 654
Query: 678 QRAELLQVLQSLEAVLIQTVYNT-KMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIG 736
R +L+ VL ++ +LI+ YN+ KMA L +++D ++A A VE C CP G
Sbjct: 655 DRDQLMTVLANVTHLLIRANYNSAKMALYRLESVSLDIASSNAIDLVVAADVEHCECPQG 714
Query: 737 YSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCK 796
Y+G SCESC + + RV G + G C C C+GHA+ C+ V+G C+ C HNT G C +C
Sbjct: 715 YTGTSCESCLSGYYRVDGILFGGICQPCECHGHAAECN-VHGVCIACAHNTTGVHCEQCL 773
Query: 797 AGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAP 856
GF+G+ + T C+PC CP AS FS TC L+ + CD CAPGY+G CE CA
Sbjct: 774 PGFYGEPSRGTPGDCQPCACPLTIASNNFSPTCHLNDGDEVVCDWCAPGYSGAWCERCAD 833
Query: 857 GYEGNPIQPGGKCRPVN-------QEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADG 909
GY GNP PG C P + E CD +GE +C N G C CADG
Sbjct: 834 GYYGNPTVPGESCVPCDCSGNVDPSEAGHCD-----SVTGECLKCLGNTDGAHCERCADG 888
Query: 910 SFHLSTRNPDGCLKCFC 926
F+ C C C
Sbjct: 889 -FYGDAVTAKNCRACEC 904
Score = 213 bits (542), Expect = 3e-54
Identities = 139/458 (30%), Positives = 210/458 (45%), Gaps = 49/458 (10%)
Query: 500 PQRGPCPDGHFYL--EHSAACLPCFCFGITSVCQSTRRF-RDQIRLRFDQPDDFKGVNVT 556
PQ C +G F L ++ C PCFC G++ +C + R + L DQP
Sbjct: 1127 PQCNECREGTFALRADNPLGCSPCFCSGLSHLCSELEDYVRTPVTLGSDQP--------- 1177
Query: 557 MPAQPGTPPLSSTQLQIDPSLHEFQL--VDLSRRFLVHDSFWALPEQFLGNKVDSYGGSL 614
+ L T + +F L + + +W LP+QF G+++ +YGG L
Sbjct: 1178 LLRVVSQSNLRGTTEGVYYQAPDFLLDAATVRQHIRAEPFYWRLPQQFQGDQLMAYGGKL 1237
Query: 615 RYNVRYELARGMLEPVQRPDVVLMGAGYR--LLSRGHTPTQPGALNQRQVQFSEEHWVH- 671
+Y+V + G+ P V++ G R ++ + G +++V E W +
Sbjct: 1238 KYSVAFYSLDGVGTSNFEPQVLIKGGRIRKQVIYMDAPAPENGVRQEQEVAMRENFWKYF 1297
Query: 672 --ESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGR---AH 726
S +PV R + + VL +E +LI+ Y + +SDI+M+ H A
Sbjct: 1298 NSVSEKPVTREDFMSVLSDIEYILIKASYGQGLQQSRISDISMEVGRKAEKLHPEEEVAS 1357
Query: 727 SVEECRCPIGYSGLSCESCDA--HFTRVPGG------PYLGTCSGCNCNGHASSCDPVYG 778
+E C CP G G SC+ C H ++P G P + C C+CN H+ +CDP G
Sbjct: 1358 LLENCVCPPGTVGFSCQDCAPGYHRGKLPAGSDRGPRPLVAPCVPCSCNNHSDTCDPNTG 1417
Query: 779 HCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQAT 838
CLNC NT G C+ C +G++G + +A+ C C CP+ FS TC L+ D
Sbjct: 1418 KCLNCGDNTAGDHCDVCTSGYYG-KVTGSASDCALCACPH-SPPASFSPTCVLEGDHDFR 1475
Query: 839 CDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSM-----GTSGEACR 893
CDAC GY G+ CE C+ Y GNP PGG C+ + C+ GS+ TSG+ C
Sbjct: 1476 CDACLLGYEGKHCERCSSSYYGNPQTPGGSCQKCD-----CNPHGSVHGDCDRTSGQ-CV 1529
Query: 894 CKNNVVGRLCNECADGSFHLSTRNPDGCLKC--FCMGV 929
C+ G C+EC + T C+ C C+GV
Sbjct: 1530 CRLGASGLRCDECEPRHILMET----DCVSCDDECVGV 1563
Score = 127 bits (320), Expect = 2e-28
Identities = 78/212 (36%), Positives = 100/212 (47%), Gaps = 28/212 (13%)
Query: 1128 CPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGH---SEA--CEPETGACQGCQHHT 1182
C PGY G C+ C GY P+ + +C C C G+ SEA C+ TG C C +T
Sbjct: 819 CAPGYSGAWCERCADGYYGNPT-VPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGNT 877
Query: 1183 EGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHS 1242
+G CE+C G+YGDA T ++C+ C C+ G + C L+T CD C P +
Sbjct: 878 DGAHCERCADGFYGDAV--TAKNCRACECH---VKGSHSAVCHLETG---LCD-CKPNVT 928
Query: 1243 GRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGL 1302
G+ C++C GYYG S G C+ CNC GSVS C GQC C V G
Sbjct: 929 GQQCDQCLHGYYGLDS-GHGCRP---------CNCSVAGSVSDGCTDEGQCHCVPGVAGK 978
Query: 1303 TCSHCRPHHFHLSASNPDGCLPCFCMGITQQC 1334
C C H F+ A C PC C C
Sbjct: 979 RCDRC-AHGFY--AYQDGSCTPCDCPHTQNTC 1007
Score = 87.4 bits (215), Expect = 3e-16
Identities = 56/145 (38%), Positives = 70/145 (48%), Gaps = 19/145 (13%)
Query: 1532 CPPGYIGLSCQDCAPGYTRTGSGLYLGH-CELCECNGHSDL-----CHPETGACSQCQHN 1585
C PGY G C+ CA GY G+ G C C+C+G+ D C TG C +C N
Sbjct: 819 CAPGYSGAWCERCADGYY--GNPTVPGESCVPCDCSGNVDPSEAGHCDSVTGECLKCLGN 876
Query: 1586 AAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGY 1645
G CE CA G+YGDA T ++C+ C C + + S C L G C+P
Sbjct: 877 TDGAHCERCADGFYGDAV--TAKNCRACEC---HVKGSHSAVCH-LETG---LCDCKPNV 927
Query: 1646 TGQYCEQCGPGYVGNPSVQGGQCLP 1670
TGQ C+QC GY G S G C P
Sbjct: 928 TGQQCDQCLHGYYGLDSGHG--CRP 950
Score = 79.3 bits (194), Expect = 8e-14
Identities = 99/443 (22%), Positives = 176/443 (39%), Gaps = 64/443 (14%)
Query: 3673 FLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQP---DFISFGLV 3729
++ LP K + E +TF ++ G++L + G +R+ F S L+
Sbjct: 2496 YIELPP-KSLSPESEWLVTFATTNSSGIIL----AALGGDVEKRGDREEAHVPFFSVMLI 2550
Query: 3730 GGRPEFRFDAGSGM----ATIRHPTPLAL-GHFHTVTLLRSLTQGSLIVGDLAPVNGTSQ 3784
GG E + G G A + PT G H+++L+R+ ++ + + PV
Sbjct: 2551 GGNIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRIITVQLDENNPVEMKLG 2610
Query: 3785 GKFQGLDLN-EELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGIS 3843
+ +N LY+GG P+ + F GC++ L E + F+ + H
Sbjct: 2611 TLVESRTINVSNLYVGGIPEGEGTSLLTMRRSFHGCIKNLIFNLELLDFN--SAVGHEQV 2668
Query: 3844 HCPTC--RDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVN 3901
TC +RP D+E S + P F PE C DA
Sbjct: 2669 DLDTCWLSERP----KLAPDAEDSKLLPE-PRAF--------------PEQCVVDAALEY 2709
Query: 3902 RPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNT-HHELRLDVEFKPL 3960
P + G+T S+ LP + +L +++ +
Sbjct: 2710 VPGAHQF---------------GLT--------QNSHFILPFNQSAVRKKLSVELSIRTF 2746
Query: 3961 APDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAER 4020
A G++ + ++ D+ L + GG L F ++LG G + L+ G+WH V +
Sbjct: 2747 ASSGLIYYMAHQNQA--DYAVLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDY 2804
Query: 4021 LNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEV 4080
+ + G + V+G + + G L++ L YLGG+ N++ C+G+V
Sbjct: 2805 VKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDV 2864
Query: 4081 SVNGKRLDLTYSFLGSQGIGQCY 4103
+VN K+LD S + + + +CY
Sbjct: 2865 TVNSKQLDKD-SPVSAFTVNRCY 2886
Score = 77.4 bits (189), Expect = 3e-13
Identities = 57/178 (32%), Positives = 95/178 (53%), Gaps = 15/178 (8%)
Query: 3942 PALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAV 4001
P +++T++ L + K PD +L + G S DF+++ M G + F ++LGSG
Sbjct: 2132 PQISSTNYNT-LTLNVKTQEPDNLLFYLG--SSTASDFLAVEMRRGRVAFLWDLGSGSTR 2188
Query: 4002 LRSAE-PLALGRWHRVSAERLNKDGSLRV-----NGGRPVLRS-SPGKSQGLNLH--TLL 4052
L + P+ RWH + R GSL V N P S SPG + L+++ TL+
Sbjct: 2189 LEFPDFPIDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLM 2248
Query: 4053 YLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGSQG-IGQCYDSSPCE 4109
++GG+ + SPA ++ HF+GC+GE +NGK + L ++++ +G C+ SS E
Sbjct: 2249 FVGGLGGQIKKSPAVKVT-HFKGCLGEAFLNGKSIGL-WNYIEREGKCRGCFGSSQNE 2304
Score = 70.1 bits (170), Expect = 5e-11
Identities = 50/171 (29%), Positives = 83/171 (48%), Gaps = 16/171 (9%)
Query: 4200 GQYGAYFHDDGFLAFPGHVFS---RSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQG 4256
G +G+ ++D F G +S +SLP I + T + +GLLL+ +G G
Sbjct: 2296 GCFGSSQNEDPSFHFDGSGYSVVEKSLPATVTQIIMLFNTFSPNGLLLY----LGSYGT- 2350
Query: 4257 KDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQV------D 4310
KDF+S+ L G + LGSG L+++ N+G W+++ R ++G + V
Sbjct: 2351 KDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTS 2410
Query: 4311 GEELVSGRSPGPNVAVNA--KGSVYIGGAPDVATLTGGRFSSGITGCVKNL 4359
+E G +PG + +N K +Y+GG P + G + GC+KNL
Sbjct: 2411 NKETKQGETPGASSDLNRLDKDPIYVGGLPRSRVVRRGVTTKSFVGCIKNL 2461
Score = 70.1 bits (170), Expect = 5e-11
Identities = 93/423 (21%), Positives = 154/423 (36%), Gaps = 99/423 (23%)
Query: 3666 FTQTPYSFLPLPTIKDAYRK-FEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFI 3724
F T S LP + A RK ++++ R ++ G++ Y + Q D+
Sbjct: 2716 FGLTQNSHFILPFNQSAVRKKLSVELSIRTFASSGLIYYMAHQN-----------QADYA 2764
Query: 3725 SFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQ 3784
L GGR F FD G G + HP L+ G +HTV +G + V T
Sbjct: 2765 VLQLHGGRLHFMFDLGKGRTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVV 2824
Query: 3785 GKFQGLDLNEELYLGGYP-DYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGIS 3843
G LD+ YLGG P Y A ++ C+ ++ + +++
Sbjct: 2825 GDGTMLDVEGLFYLGGLPSQYQARKIGNITHSIPACIGDVTVNSKQL------------- 2871
Query: 3844 HCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRP 3903
+D P + FT +RC A + T
Sbjct: 2872 ----DKDSPV-------------------SAFTVNRC----------YAVAQEGTYF--- 2895
Query: 3904 DGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELRLDVEFKPLAPD 3963
DG GY L + G + + V +T +EF+ + +
Sbjct: 2896 DGSGYAA---LVKEGYKVQSDVNIT--------------------------LEFRTSSQN 2926
Query: 3964 GVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVL----RSAEPLALGRWHRVSAE 4019
GVLL G S D + L +V G + F G+G ++A L G+WH + A
Sbjct: 2927 GVLL---GISTAKVDAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQAN 2983
Query: 4020 RLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGE 4079
+ +L V+G S +S ++ + +Y+GG P+ FRGC+ +
Sbjct: 2984 KSKHRITLIVDGNAVGAESPHTQSTSVDTNNPIYVGGY-PAGVKQKCLRSQTSFRGCLRK 3042
Query: 4080 VSV 4082
+++
Sbjct: 3043 LAL 3045
Score = 64.3 bits (155), Expect = 3e-09
Identities = 51/147 (34%), Positives = 59/147 (40%), Gaps = 24/147 (16%)
Query: 1525 LEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGH-CELCECN---GHSDLCHPETGACS 1580
LE C C P G C C GY GL GH C C C+ SD C E G C
Sbjct: 916 LETGLCDCKPNVTGQQCDQCLHGY----YGLDSGHGCRPCNCSVAGSVSDGCTDE-GQC- 969
Query: 1581 QCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTA 1640
C AG+ C+ CA G+Y A C PC CP T TC+ C
Sbjct: 970 HCVPGVAGKRCDRCAHGFY----AYQDGSCTPCDCPHT------QNTCDPETG---EC-V 1015
Query: 1641 CEPGYTGQYCEQCGPGYVGNPSVQGGQ 1667
C P G CE+C G+ G + G Q
Sbjct: 1016 CPPHTQGVKCEECEDGHWGYDAEVGCQ 1042
Score = 63.5 bits (153), Expect = 4e-09
Identities = 40/146 (27%), Positives = 67/146 (45%), Gaps = 6/146 (4%)
Query: 4219 FSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSG 4278
F++S ++EL +RT +SGL+ + + D+ L L G L F + LG G
Sbjct: 2728 FNQSAVRKKLSVELSIRTFASSGLIYYMAHQ-----NQADYAVLQLHGGRLHFMFDLGKG 2782
Query: 4279 EARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAP 4338
++ ++DG+WH V R+G I VDG E G ++ +G Y+GG P
Sbjct: 2783 RTKVSHPALLSDGKWHTVKTDYVKRKGFITVDGRESPMVTVVGDGTMLDVEGLFYLGGLP 2842
Query: 4339 -DVATLTGGRFSSGITGCVKNLVLHS 4363
G + I C+ ++ ++S
Sbjct: 2843 SQYQARKIGNITHSIPACIGDVTVNS 2868
Score = 59.7 bits (143), Expect = 6e-08
Identities = 46/168 (27%), Positives = 73/168 (43%), Gaps = 13/168 (7%)
Query: 4198 APGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGK 4257
A Q G YF G+ A + + I LE RTS+ +G+LL G+ +
Sbjct: 2887 AVAQEGTYFDGSGYAALVKEGYK---VQSDVNITLEFRTSSQNGVLL--GISTAKV---- 2937
Query: 4258 DFISLGLQDGHLVFRYQLGSGEARLVSEDP----INDGEWHRVTALREGRRGSIQVDGEE 4313
D I L L DG ++F G+G E + DG+WH + A + R ++ VDG
Sbjct: 2938 DAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNA 2997
Query: 4314 LVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361
+ + + +V+ +Y+GG P R + GC++ L L
Sbjct: 2998 VGAESPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLAL 3045
Score = 52.4 bits (124), Expect = 1e-05
Identities = 35/117 (29%), Positives = 55/117 (47%), Gaps = 14/117 (11%)
Query: 4229 TIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSED-P 4287
T+ L V+T LL + G + DF+++ ++ G + F + LGSG RL D P
Sbjct: 2141 TLTLNVKTQEPDNLLFYLG-----SSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFP 2195
Query: 4288 INDGEWHRVTALREGRRGSIQV----DGEELVSGRSPGPNVA----VNAKGSVYIGG 4336
I+D WH + R G GS+ V ++ + S P A VN +++GG
Sbjct: 2196 IDDNRWHSIHVARFGNIGSLSVKEMSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGG 2252
Score = 50.8 bits (120), Expect = 3e-05
Identities = 42/147 (28%), Positives = 64/147 (43%), Gaps = 19/147 (12%)
Query: 3687 EIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATI 3746
+I + F S +G+LLY G DF+S L GR + D GSG T+
Sbjct: 2328 QIIMLFNTFSPNGLLLYLGSYGTK-----------DFLSIELFRGRVKVMTDLGSGPITL 2376
Query: 3747 RHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNG--TSQGKFQGL--DLN----EELYL 3798
G ++ + R+ QG L V D + T QG+ G DLN + +Y+
Sbjct: 2377 LTDRRYNNGTWYKIAFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYV 2436
Query: 3799 GGYPDYGAIPKAGLSSGFIGCVRELRI 3825
GG P + + + F+GC++ L I
Sbjct: 2437 GGLPRSRVVRRGVTTKSFVGCIKNLEI 2463
Score = 49.3 bits (116), Expect = 8e-05
Identities = 32/118 (27%), Positives = 50/118 (42%), Gaps = 20/118 (16%)
Query: 711 AMDTTVTHATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHA 770
A + ++ +T H C+C + G +C+ C + P C C+C+
Sbjct: 1043 ACNCSLVGSTHHRCDVVTGHCQCKSKFGGRACDQCSLGYRDFP------DCVPCDCDLRG 1096
Query: 771 SS---CDPVYGHC--------LNCQHNTEGPQCNKCKAGFFGDAMKA-TATSCRPCPC 816
+S C+ G C C+ N GPQCN+C+ G F A++A C PC C
Sbjct: 1097 TSGDACNLEQGLCGCVEETGACPCKENVFGPQCNECREGTF--ALRADNPLGCSPCFC 1152
Score = 48.9 bits (115), Expect = 1e-04
Identities = 38/147 (25%), Positives = 67/147 (45%), Gaps = 11/147 (7%)
Query: 3957 FKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRV 4016
F +P+G+LL+ G S +DF+S+ + G ++ +LGSG L + G W+++
Sbjct: 2333 FNTFSPNGLLLYLG--SYGTKDFLSIELFRGRVKVMTDLGSGPITLLTDRRYNNGTWYKI 2390
Query: 4017 SAERLNKDGSLRV------NGGRPVLRSSPGKSQGLNL--HTLLYLGGVEPSVPLSPATN 4068
+ +R K G L V + +PG S LN +Y+GG+ S +
Sbjct: 2391 AFQRNRKQGVLAVIDAYNTSNKETKQGETPGASSDLNRLDKDPIYVGGLPRSRVVRRGVT 2450
Query: 4069 MSAHFRGCVGEVSVNGKRLDLTYSFLG 4095
+ F GC+ + ++ DL + G
Sbjct: 2451 TKS-FVGCIKNLEISRSTFDLLRNSYG 2476
Score = 47.4 bits (111), Expect = 3e-04
Identities = 44/168 (26%), Positives = 73/168 (43%), Gaps = 23/168 (13%)
Query: 3665 YFTQTPYSFLPLPTIKDAYR---KFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQP 3721
YF + Y+ L +K+ Y+ I + FR S +G+LL ++ +
Sbjct: 2894 YFDGSGYAAL----VKEGYKVQSDVNITLEFRTSSQNGVLL------------GISTAKV 2937
Query: 3722 DFISFGLVGGRPEFRFDAGSGMATIRHP----TPLALGHFHTVTLLRSLTQGSLIVGDLA 3777
D I LV G+ F + G+G T + T L G +HT+ +S + +LIV A
Sbjct: 2938 DAIGLELVDGKVLFHVNNGAGRITAAYEPKTATVLCDGKWHTLQANKSKHRITLIVDGNA 2997
Query: 3778 PVNGTSQGKFQGLDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRI 3825
+ + +D N +Y+GGYP + F GC+R+L +
Sbjct: 2998 VGAESPHTQSTSVDTNNPIYVGGYPAGVKQKCLRSQTSFRGCLRKLAL 3045
Score = 38.5 bits (88), Expect = 0.15
Identities = 33/114 (28%), Positives = 48/114 (42%), Gaps = 20/114 (17%)
Query: 4084 GKRLDLTYSFLGSQGIGQCYDSSPC---ERQPCQHGATCMPAGEYEFQC-LCRDGFKGDL 4139
G D+ S + G D + C P TC+ G+++F+C C G++G
Sbjct: 1428 GDHCDVCTSGYYGKVTGSASDCALCACPHSPPASFSPTCVLEGDHDFRCDACLLGYEGKH 1487
Query: 4140 CE-----HEENP------CQLREPCLHG---GTCQGT--RCLCLPGFSGPRCQQ 4177
CE + NP CQ + HG G C T +C+C G SG RC +
Sbjct: 1488 CERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLRCDE 1541
Score = 36.6 bits (83), Expect = 0.56
Identities = 54/243 (22%), Positives = 91/243 (37%), Gaps = 52/243 (21%)
Query: 3605 DISWSKLDGSLPPDSRLENNM--------LMLPSVRPQDAGTYVCTATNRQGKVKAFAHL 3656
+I + L L P LE N+ L++ R Q A V + +R ++A+
Sbjct: 2075 EIQANLLFDRLKPLKMLEENLSRNLSEIKLLISQARKQAASIKVAVSADRDC-IRAYQ-- 2131
Query: 3657 QVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNL 3716
P + T Y+ L L + D +L Y G
Sbjct: 2132 -------PQISSTNYNTLTL--------------NVKTQEPDNLLFYLG----------- 2159
Query: 3717 ANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPT-PLALGHFHTVTLLRSLTQGSLIVGD 3775
++ DF++ + GR F +D GSG + P P+ +H++ + R GSL V +
Sbjct: 2160 SSTASDFLAVEMRRGRVAFLWDLGSGSTRLEFPDFPIDDNRWHSIHVARFGNIGSLSVKE 2219
Query: 3776 LA------PVNGTSQGKFQGLDLNEE--LYLGGYPDYGAIPKAGLSSGFIGCVRELRIQG 3827
++ S G LD+N +++GG A + F GC+ E + G
Sbjct: 2220 MSSNQKSPTKTSKSPGTANVLDVNNSTLMFVGGLGGQIKKSPAVKVTHFKGCLGEAFLNG 2279
Query: 3828 EEI 3830
+ I
Sbjct: 2280 KSI 2282
Score = 35.0 bits (79), Expect = 1.6
Identities = 19/63 (30%), Positives = 24/63 (38%), Gaps = 10/63 (15%)
Query: 3871 CPAGFTGSRCEHSQALH----------CHPEACGPDATCVNRPDGRGYTCRCHLGRSGLR 3920
C G+ G CE + + C C P + D C C LG SGLR
Sbjct: 1479 CLLGYEGKHCERCSSSYYGNPQTPGGSCQKCDCNPHGSVHGDCDRTSGQCVCRLGASGLR 1538
Query: 3921 CEE 3923
C+E
Sbjct: 1539 CDE 1541
Score = 34.3 bits (77), Expect = 2.8
Identities = 30/112 (26%), Positives = 37/112 (33%), Gaps = 16/112 (14%)
Query: 3840 HGISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHS-------QALHCHP-- 3890
+G+ CR C G D + C C G G RC+ Q C P
Sbjct: 940 YGLDSGHGCRPCNCSVAGSVSDGCTDEGQCHCVPGVAGKRCDRCAHGFYAYQDGSCTPCD 999
Query: 3891 -----EACGPD-ATCVNRPDGRGYTC-RCHLGRSGLRCEEGVTVTTPSLSGA 3935
C P+ CV P +G C C G G E G SL G+
Sbjct: 1000 CPHTQNTCDPETGECVCPPHTQGVKCEECEDGHWGYDAEVGCQACNCSLVGS 1051
Score = 34.3 bits (77), Expect = 2.8
Identities = 42/174 (24%), Positives = 75/174 (43%), Gaps = 30/174 (17%)
Query: 3936 GSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGG----KSGPVED----FVSLAMVGG 3987
G Y+ LP + + L V F G++L + G K G E+ F S+ ++GG
Sbjct: 2494 GGYIELPPKSLSPESEWL-VTFATTNSSGIILAALGGDVEKRGDREEAHVPFFSVMLIGG 2552
Query: 3988 HLEFRYELGSGLAVLRS-------------AEPLALGRWHRVSAERLNKDGSLRVNGGRP 4034
++E G G + ++ A ++L R R+ +L+++ + + G
Sbjct: 2553 NIEVHVNPGDGTGLRKALLHAPTGTCSDGQAHSISLVRNRRIITVQLDENNPVEMKLGTL 2612
Query: 4035 VLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLD 4088
V +S+ +N+ LY+GG+ S T M F GC+ + N + LD
Sbjct: 2613 V------ESRTINVSN-LYVGGIPEGEGTSLLT-MRRSFHGCIKNLIFNLELLD 2658
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 329 bits (844), Expect = 3e-89
Identities = 253/790 (32%), Positives = 352/790 (44%), Gaps = 131/790 (16%)
Query: 3637 GTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDS 3696
G + C+ +G L P VP F SFL PT++ AY + + FR
Sbjct: 1351 GGFTCSCPAGRGGAVCEKVLGAP---VPAFEGR--SFLAFPTLR-AYHTLRLALEFRALE 1404
Query: 3697 ADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGH 3756
G+LLYNG R DF++ L+ GR + RFD GSG A + P+ G
Sbjct: 1405 PQGLLLYNGNAR-----------GKDFLALALLDGRVQLRFDTGSGPAVLTSAVPVEPGQ 1453
Query: 3757 FHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGA---IPKAGLS 3813
+H + L R +G+L V PV G S GL+L+ +L++GG P+ A + + +
Sbjct: 1454 WHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALERTFVG 1513
Query: 3814 SGFIGCVRELRIQGEEI---VFHDLNLTAHGISHCPT--CRDRPCQNGGQCHDSESSSYV 3868
+G GC+R L + + + + G+ C C PC G C + E+ +
Sbjct: 1514 AGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDHPCLPNPCHGGAPCQNLEAGRFH 1573
Query: 3869 CVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVT 3928
C CP G G C ++ C P C A C P+G G C C LGR G C+ T
Sbjct: 1574 CQCPPGRVGPTCADEKS-PCQPNPCHGAAPCRVLPEG-GAQCECPLGREGTFCQ-----T 1626
Query: 3929 TPSLSGAGSYLALPALTNTHHELR--------------LDVEFKPLAPDGVLLFSGGKSG 3974
G+G +LA +H ELR L+V F P G+LL++G K+
Sbjct: 1627 ASGQDGSGPFLA-DFNGFSHLELRGLHTFARDLGEKMALEVVFLARGPSGLLLYNGQKTD 1685
Query: 3975 PVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAERLNKDGSLRVNGGRP 4034
DFVSLA+ LEFRY+LG G AV+RS EP+ LG W RVS ER + G+LRV G
Sbjct: 1686 GKGDFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTRVSLERNGRKGALRVGDGPR 1745
Query: 4035 VLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYSFL 4094
VL SP LNL LY+GG L+ A +S+ F G + VS+ G++L LT +
Sbjct: 1746 VLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDGAIQLVSLGGRQL-LTPEHV 1804
Query: 4095 GSQGIGQCYDSSPCER---QPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLRE 4151
Q + PC R PC +GA+C+P E + CLC GF
Sbjct: 1805 LRQVDVTSFAGHPCTRASGHPCLNGASCVPR-EAAYVCLCPGGF---------------- 1847
Query: 4152 PCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGF 4211
SGP C++G +E S G D
Sbjct: 1848 -------------------SGPHCEKGL----------VEKSAG------------DVDT 1866
Query: 4212 LAFPGHVFSRSLPEVPET--------IELEVRTSTASGLLLWQGVEVGEAGQGKDFISLG 4263
LAF G F L V E+ EL +RT GL+LW G+A + D+++L
Sbjct: 1867 LAFDGRTFVEYLNAVTESEKALQSNHFELSLRTEATQGLVLWS----GKATERADYVALA 1922
Query: 4264 LQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPN 4323
+ DGHL Y LGS L S P+N W RV A RE R GS+QV E V+G SP
Sbjct: 1923 IVDGHLQLSYNLGSQPVVLRSTVPVNTNRWLRVVAHREQREGSLQVGNEAPVTGSSPLGA 1982
Query: 4324 VAVNAKGSVYIGGAPD--VATLTGGRFSSGITGCVKNLVLHSARPGAPPPQPLDLQHRAQ 4381
++ G++++GG P+ V + +G GC++++V+ PL L A
Sbjct: 1983 TQLDTDGALWLGGLPELPVGPALPKAYGTGFVGCLRDVVVGR--------HPLHLLEDAV 2034
Query: 4382 AGANTRPCPS 4391
RPCP+
Sbjct: 2035 TKPELRPCPT 2044
Score = 276 bits (707), Expect = 2e-73
Identities = 179/483 (37%), Positives = 248/483 (51%), Gaps = 39/483 (8%)
Query: 3888 CHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNT 3947
C + C TC + G G+TC C GR G CE+ + P+ G S+LA P L
Sbjct: 1333 CDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCEKVLGAPVPAFEGR-SFLAFPTL-RA 1390
Query: 3948 HHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEP 4007
+H LRL +EF+ L P G+LL++G G +DF++LA++ G ++ R++ GSG AVL SA P
Sbjct: 1391 YHTLRLALEFRALEPQGLLLYNGNARG--KDFLALALLDGRVQLRFDTGSGPAVLTSAVP 1448
Query: 4008 LALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGV---EPSVPLS 4064
+ G+WHR+ R + G+L V+G PVL SP + GLNL T L++GGV + +V L
Sbjct: 1449 VEPGQWHRLELSRHWRRGTLSVDGETPVLGESPSGTDGLNLDTDLFVGGVPEDQAAVALE 1508
Query: 4065 PATNMSAHFRGCVGEVSVNGKRLDLTY---SFLGSQGIGQCYDSSPCERQPCQHGATCMP 4121
T + A RGC+ + VN +RL+L + G+G+C D PC PC GA C
Sbjct: 1509 -RTFVGAGLRGCIRLLDVNNQRLELGIGPGAATRGSGVGECGDH-PCLPNPCHGGAPCQN 1566
Query: 4122 AGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQ-----GTRCLCLPGFSGPRCQ 4176
F C C G G C E++PCQ PC C+ G +C C G G CQ
Sbjct: 1567 LEAGRFHCQCPPGRVGPTCADEKSPCQ-PNPCHGAAPCRVLPEGGAQCECPLGREGTFCQ 1625
Query: 4177 QGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPG-HVFSRSLPEVPETIELEVR 4235
SG D G + A F+ L G H F+R L E +E+
Sbjct: 1626 TASGQ---------------DGSGPFLADFNGFSHLELRGLHTFARDLGE-KMALEVVFL 1669
Query: 4236 TSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHR 4295
SGLLL+ G + G DF+SL L+D L FRY LG G A + S +P+ G W R
Sbjct: 1670 ARGPSGLLLYNGQKTDGKG---DFVSLALRDRRLEFRYDLGKGAAVIRSREPVTLGAWTR 1726
Query: 4296 VTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLT-GGRFSSGITG 4354
V+ R GR+G+++V V G SP P+ +N K +Y+GGAPD + L SSG G
Sbjct: 1727 VSLERNGRKGALRVGDGPRVLGESPVPHTVLNLKEPLYVGGAPDFSKLARAAAVSSGFDG 1786
Query: 4355 CVK 4357
++
Sbjct: 1787 AIQ 1789
Score = 65.5 bits (158), Expect = 1e-09
Identities = 70/271 (25%), Positives = 88/271 (32%), Gaps = 65/271 (23%)
Query: 1115 TGQDPALEVEQCSCPPGYRGPSCQD----CDTGYTRTPSGLYLGT---CERCSCHGHSEA 1167
+G+D E E C G +D CD P G+ C
Sbjct: 676 SGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKAR 735
Query: 1168 CEPETGACQGCQHHTEGPRCE--------QCQPGYYGDAQ-----------RGTPQDCQL 1208
CE + G Q GP C YG Q G P CQ
Sbjct: 736 CESQRGLYVAAQGACRGPTFAPLPPVAPLHCAQTPYGCCQDNITAARGVGLAGCPSACQC 795
Query: 1209 CP--CYG---DPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYY---GNPSQG 1260
P YG DPA GQ + C PG G C+RC PG++ G + G
Sbjct: 796 NPHGSYGGTCDPATGQCS---------------CRPGVGGLRCDRCEPGFWNFRGIVTDG 840
Query: 1261 QPCQRDSQVPGPIGCNCDPQGSVSSQCD-AAGQCQCKAQVEGLTCSHC------RPHHFH 1313
+ G C+CDPQG+V C+ G C CK V G C C P
Sbjct: 841 R--------SGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQCPDGRALGPAGCE 892
Query: 1314 LSASNPDGCLPCFCMGITQQCASSAYTRHLI 1344
AS P C C +C + + H +
Sbjct: 893 ADASAPATCAEMRC-EFGARCVEESGSAHCV 922
Score = 65.1 bits (157), Expect = 1e-09
Identities = 67/245 (27%), Positives = 93/245 (37%), Gaps = 39/245 (15%)
Query: 745 CDAHFTRVPGGPYLGTCSGCNCNGHAS---SCDPVYGHCLNCQHNTEGPQCNKCKAGF-- 799
C + T G G S C CN H S +CDP G C +C+ G +C++C+ GF
Sbjct: 774 CQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQC-SCRPGVGGLRCDRCEPGFWN 832
Query: 800 FGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYE 859
F + + C PC C D D C T C +C PG G +C C +
Sbjct: 833 FRGIVTDGRSGCTPCSC---DPQGAVRDDCEQMT---GLC-SCKPGVAGPKCGQCP---D 882
Query: 860 GNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFH-----LS 914
G + P G C+ S + RC+ G C E GS H L+
Sbjct: 883 GRALGPAG-----------CEADASAPATCAEMRCE---FGARCVE-ESGSAHCVCPMLT 927
Query: 915 TRNPDGCLKCFCMGVS--RHCTSSSWS-RAQLHGASEEPGHFSLTNAASTHTTNEGIFSP 971
+ C GV+ C + + R L + + G A STH T+ +
Sbjct: 928 CPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEAVAPSTHPTSASVTVT 987
Query: 972 TPGEL 976
TPG L
Sbjct: 988 TPGLL 992
Score = 60.8 bits (146), Expect = 3e-08
Identities = 39/126 (30%), Positives = 52/126 (41%), Gaps = 16/126 (12%)
Query: 1544 CAPGYTRTGSGLYLGHC-ELCECNGHSDL---CHPETGACSQCQHNAAGEFCELCAPGYY 1599
C G+ L C C+CN H C P TG CS C+ G C+ C PG++
Sbjct: 773 CCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCS-CRPGVGGLRCDRCEPGFW 831
Query: 1600 ---GDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPG 1656
G T G C PC+C +P+ CE + +C+PG G C QC G
Sbjct: 832 NFRGIVTDGR-SGCTPCSC---DPQGAVRDDCEQMTG----LCSCKPGVAGPKCGQCPDG 883
Query: 1657 YVGNPS 1662
P+
Sbjct: 884 RALGPA 889
Score = 49.3 bits (116), Expect = 8e-05
Identities = 53/206 (25%), Positives = 68/206 (33%), Gaps = 48/206 (23%)
Query: 745 CDAHFTRVPGGPYLGTCS---GCNCNGHASSCDPVYGHCLNCQHNTEGP----------- 790
CD VPG P G+ C + C+ G + Q GP
Sbjct: 705 CDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPTFAPLPPVAPL 764
Query: 791 QCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQ--ATCD------AC 842
C + G D + A A CP C + G TCD +C
Sbjct: 765 HCAQTPYGCCQDNITA-ARGVGLAGCP---------SACQCNPHGSYGGTCDPATGQCSC 814
Query: 843 APGYTGRRCESCAPG---YEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGE----ACRCK 895
PG G RC+ C PG + G C P + CD +G++ E C CK
Sbjct: 815 RPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCS-----CDPQGAVRDDCEQMTGLCSCK 869
Query: 896 NNVVGRLCNECADGSFHLSTRNPDGC 921
V G C +C DG P GC
Sbjct: 870 PGVAGPKCGQCPDG----RALGPAGC 891
Score = 48.5 bits (114), Expect = 1e-04
Identities = 45/149 (30%), Positives = 53/149 (35%), Gaps = 34/149 (22%)
Query: 1529 ECRCPPGYIGLSCQDCAPGYTRTGSGLYLGH--CELCECNGHS---DLCHPETGACSQCQ 1583
+C C PG GL C C PG+ + G C C C+ D C TG CS C+
Sbjct: 811 QCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCS-CK 869
Query: 1584 HNAAGEFCELCAPGYY-----GDATAGTPEDCQP-----------------CACP-LTNP 1620
AG C C G +A A P C C CP LT P
Sbjct: 870 PGVAGPKCGQCPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCP 929
Query: 1621 ENMFSRTCESLGAG-GYRC----TACEPG 1644
E ++ C S G G C AC G
Sbjct: 930 EANATKVCGSDGVTYGNECQLKTIACRQG 958
Score = 46.2 bits (108), Expect = 7e-04
Identities = 35/106 (33%), Positives = 42/106 (39%), Gaps = 16/106 (15%)
Query: 1546 PGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAG 1605
PG GSG+ EC H L +P G + CQ+ AG F C PG G A
Sbjct: 1536 PGAATRGSGVG-------ECGDHPCLPNPCHGG-APCQNLEAGRFHCQCPPGRVGPTCAD 1587
Query: 1606 TPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCE 1651
CQP C P C L GG +C C G G +C+
Sbjct: 1588 EKSPCQPNPCHGAAP-------CRVLPEGGAQC-ECPLGREGTFCQ 1625
Score = 44.3 bits (103), Expect = 0.003
Identities = 30/115 (26%), Positives = 47/115 (40%), Gaps = 9/115 (7%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGT--CSGCNCNGHAS---SCDPVYGHCLNCQ 784
+C C G GL C+ C+ F G G C+ C+C+ + C+ + G C +C+
Sbjct: 811 QCSCRPGVGGLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLC-SCK 869
Query: 785 HNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATC 839
GP+C +C G A + P C + F C ++ G A C
Sbjct: 870 PGVAGPKCGQCPDGRALGPAGCEADASAPATC--AEMRCEFGARC-VEESGSAHC 921
Score = 38.5 bits (88), Expect = 0.15
Identities = 40/143 (27%), Positives = 45/143 (31%), Gaps = 33/143 (23%)
Query: 1528 EECRCPPGYIGLSCQDCAPGYTRTGSG--LYLGHCEL--CECNGHSDLCHPETGACS--- 1580
E+ P SCQ PG GS Y CEL C L GAC
Sbjct: 696 EDSEDGPCVCDFSCQS-VPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACRGPT 754
Query: 1581 ----------QCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCES 1630
C G C+ G AG P CQ NP + TC+
Sbjct: 755 FAPLPPVAPLHCAQTPYG-CCQDNITAARGVGLAGCPSACQ------CNPHGSYGGTCDP 807
Query: 1631 L--------GAGGYRCTACEPGY 1645
G GG RC CEPG+
Sbjct: 808 ATGQCSCRPGVGGLRCDRCEPGF 830
Score = 36.6 bits (83), Expect = 0.56
Identities = 29/102 (28%), Positives = 38/102 (37%), Gaps = 23/102 (22%)
Query: 4096 SQGIGQCYDSSPCERQPC-QHGATCMPAGEYEFQCLCRDGFKGDLCEHEE---------- 4144
++G+G S C+ P +G TC PA QC CR G G C+ E
Sbjct: 781 ARGVGLAGCPSACQCNPHGSYGGTCDPATG---QCSCRPGVGGLRCDRCEPGFWNFRGIV 837
Query: 4145 -------NPCQLREPCLHGGTCQGTR--CLCLPGFSGPRCQQ 4177
PC C+ C C PG +GP+C Q
Sbjct: 838 TDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQ 879
Score = 35.8 bits (81), Expect = 0.96
Identities = 43/158 (27%), Positives = 58/158 (36%), Gaps = 24/158 (15%)
Query: 1100 SRVSGISMDV-----AVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLG 1154
S G+++D VPE+ A+ +E+ G RG + D R G+ G
Sbjct: 1482 SGTDGLNLDTDLFVGGVPEDQA---AVALERTFVGAGLRG-CIRLLDVNNQRLELGIGPG 1537
Query: 1155 TCERCSCHGH--SEACEPETGACQG---CQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLC 1209
R S G C P C G CQ+ G QC PG G CQ
Sbjct: 1538 AATRGSGVGECGDHPCLPNP--CHGGAPCQNLEAGRFHCQCPPGRVGPTCADEKSPCQPN 1595
Query: 1210 PCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCE 1247
PC+G A C + +G C+ C G G C+
Sbjct: 1596 PCHG-------AAPCRVLPEGGAQCE-CPLGREGTFCQ 1625
Score = 35.4 bits (80), Expect = 1.3
Identities = 17/36 (47%), Positives = 19/36 (52%), Gaps = 1/36 (2%)
Query: 4107 PCERQPCQHGATCMP-AGEYEFQCLCRDGFKGDLCE 4141
PC+ QPC HG TC A F C C G G +CE
Sbjct: 1332 PCDSQPCFHGGTCQDWALGGGFTCSCPAGRGGAVCE 1367
Score = 33.1 bits (74), Expect = 6.2
Identities = 33/137 (24%), Positives = 43/137 (31%), Gaps = 30/137 (21%)
Query: 1164 HSEACEPETGAC---QGCQHHTEGP--RCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAG 1218
+ ACE E AC + Q +GP RC QC+ G +A+ G C P G
Sbjct: 509 YGSACELEATACTLGREIQVARKGPCDRCGQCRFGALCEAETGRCVCPSECVALAQPVCG 568
Query: 1219 QAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCD 1278
HT P H C + + PC+ G C
Sbjct: 569 SDGHT--------------YPSECMLHVHACTHQISLHVASAGPCETCGDAVCAFGAVC- 613
Query: 1279 PQGSVSSQCDAAGQCQC 1295
+AGQC C
Sbjct: 614 ----------SAGQCVC 620
Score = 33.1 bits (74), Expect = 6.2
Identities = 20/65 (30%), Positives = 28/65 (43%), Gaps = 15/65 (23%)
Query: 1530 CRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCH--PETGACSQCQHNAA 1587
C+CPPG +G +C D C+ C+G + C PE GA +C
Sbjct: 1574 CQCPPGRVGPTCAD------------EKSPCQPNPCHGAAP-CRVLPEGGAQCECPLGRE 1620
Query: 1588 GEFCE 1592
G FC+
Sbjct: 1621 GTFCQ 1625
>gi|21264602 laminin alpha 5 [Homo sapiens]
Length = 3695
Score = 324 bits (830), Expect = 1e-87
Identities = 201/555 (36%), Positives = 259/555 (46%), Gaps = 51/555 (9%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEG 1184
QC C G C C TGY P+ C C C + C+ TG C C T
Sbjct: 1456 QCPCHAHVIGRDCSRCATGYWGFPN------CRPCDCG--ARLCDELTGQCI-CPPRTIP 1506
Query: 1185 PRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGR 1244
P C CQP +G C+ C C G TC DTD C P +GR
Sbjct: 1507 PDCLLCQPQTFGCHPL---VGCEECNCSGPGIQELTDPTC--DTDSGQC--KCRPNVTGR 1559
Query: 1245 HCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDA-AGQCQCKAQVEGLT 1303
C+ C+PG++G P C+ C+C G+ CD GQC CK V+G
Sbjct: 1560 RCDTCSPGFHGYPR----CRP---------CDCHEAGTAPGVCDPLTGQCYCKENVQGPK 1606
Query: 1304 CSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGFALVNPQR 1363
C C F L A+NP GC CFC G T++C SS+YTR D +G+ L++ R
Sbjct: 1607 CDQCSLGTFSLDAANPKGCTRCFCFGATERCRSSSYTRQEFV------DMEGWVLLSTDR 1660
Query: 1364 NSRLTGEFTVEPVPEGAQLSFGNFAQLGHESF---YWQLPETYQGDKVAAYGGKLRYTLS 1420
+P E + + + E+F YWQ P +Y GD+V++YGG LRY L
Sbjct: 1661 Q---VVPHERQPGTEMLRADLRHVPEAVPEAFPELYWQAPPSYLGDRVSSYGGTLRYELH 1717
Query: 1421 YTA--GPQGSPL-SDPDVQITGNNIMLVASQPALQGPER--RSYEIMFREEFWRRPDGQP 1475
G P+ S PDV + GN + + +PA P R + F
Sbjct: 1718 SETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNT 1777
Query: 1476 ATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNRPRALEVEECRCPPG 1535
+RE L+M LA L++L IRA FS + A + V+LEVA P A VE C CP
Sbjct: 1778 VSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGA-LASNVELCLCPAS 1836
Query: 1536 YIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCA 1595
Y G SCQ+CAPG+ R GL+LG C C+C+GHSD C P +G C CQHN G CE C
Sbjct: 1837 YRGDSCQECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEGAHCERCQ 1896
Query: 1596 PGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGP 1655
G+ + C C CPL+ P N F+ C + GG C+PGY G CE+C P
Sbjct: 1897 AGFV-SSRDDPSAPCVSCPCPLSVPSNNFAEGC--VLRGGRTQCLCKPGYAGASCERCAP 1953
Query: 1656 GYVGNPSVQGGQCLP 1670
G+ GNP V G C P
Sbjct: 1954 GFFGNPLVLGSSCQP 1968
Score = 317 bits (811), Expect = 2e-85
Identities = 217/670 (32%), Positives = 290/670 (43%), Gaps = 125/670 (18%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEG 789
+C C G C C + P C C+C A CD + G C+ C T
Sbjct: 1456 QCPCHAHVIGRDCSRCATGYWGFPN------CRPCDCG--ARLCDELTGQCI-CPPRTIP 1506
Query: 790 PQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTD-GQATCDACAPGYTG 848
P C C+ FG C C C TC DTD GQ C P TG
Sbjct: 1507 PDCLLCQPQTFGCH---PLVGCEECNCSGPGIQELTDPTC--DTDSGQCKC---RPNVTG 1558
Query: 849 RRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMG-----TSGEACRCKNNVVGRLC 903
RRC++C+PG+ G P +CRP + C E G+ +G+ C CK NV G C
Sbjct: 1559 RRCDTCSPGFHGYP-----RCRPCD-----CHEAGTAPGVCDPLTGQ-CYCKENVQGPKC 1607
Query: 904 NECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRA---------------QLHGASE 948
++C+ G+F L NP GC +CFC G + C SSS++R Q+
Sbjct: 1608 DQCSLGTFSLDAANPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQVVPHER 1667
Query: 949 EPGHFSLTNAASTHTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYGGE 1008
+PG L A E + P +W P +LGD+V+SYGG
Sbjct: 1668 QPGTEMLR--ADLRHVPEAVPEAFP--------------ELYWQAPPSYLGDRVSSYGGT 1711
Query: 1009 LRFTVTQRSQPGST--PLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQR 1066
LR+ + +Q G P+ +P VVLQGN + + P+PG + E ++
Sbjct: 1712 LRYELHSETQRGDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRH 1771
Query: 1067 PDGQ-PATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQ 1125
+ + +RE L+M LA ++ L IRA ++Q + + ++++VA P G A VE
Sbjct: 1772 TETRNTVSREELMMVLASLEQLQIRALFSQISSAVFLRRVALEVASPAGQGA-LASNVEL 1830
Query: 1126 CSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGP 1185
C CP YRG SCQ+C G+ R GL+LG C C CHGHS+ C P +G C CQH+TEG
Sbjct: 1831 CLCPASYRGDSCQECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEGA 1890
Query: 1186 RCEQCQPGYYGDAQRGTPQ-DCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGR 1244
CE+CQ G+ + R P C CPC + A C L G C C PG++G
Sbjct: 1891 HCERCQAGFV--SSRDDPSAPCVSCPCPLSVPSNNFAEGCVL-RGGRTQC-LCKPGYAGA 1946
Query: 1245 HCERCAPGYYGNP----SQGQPCQRDSQ-------------------------------- 1268
CERCAPG++GNP S QPC
Sbjct: 1947 SCERCAPGFFGNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEIC 2006
Query: 1269 VPGPIG----------CNCDPQGSVSSQCDA-AGQCQCKAQVEGLTCSHCRPHHFHLSAS 1317
PG G C+C P G + CD +G C CKA V G C C+ HF
Sbjct: 2007 APGFYGNALLPGNCTRCDCTPCG--TEACDPHSGHCLCKAGVTGRRCDRCQEGHFGFDGC 2064
Query: 1318 NPDGCLPCFC 1327
GC PC C
Sbjct: 2065 G--GCRPCAC 2072
Score = 227 bits (579), Expect = 2e-58
Identities = 196/675 (29%), Positives = 278/675 (41%), Gaps = 109/675 (16%)
Query: 292 CRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEP--NEFPCGN-------GHCALKLW 342
CRN + +G C G E+ P CEP + PC CA W
Sbjct: 1420 CRNAAASLSLFYNNGARPC--GCHEVGA-TGPTCEPFGGQCPCHAHVIGRDCSRCATGYW 1476
Query: 343 R------CD-GDFDCEDRTDEANCPTKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCP 395
CD G C++ T + CP + C +C P +F C C
Sbjct: 1477 GFPNCRPCDCGARLCDELTGQCICPPRTIPPDC----------LLCQPQTFGCHPLVGC- 1525
Query: 396 DRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTV 455
+E C P + + GQ P + R R
Sbjct: 1526 ---EECNCSGPGIQELTDPTCDTDSGQCKC---------RPNVTGR----------RCDT 1563
Query: 456 TSEGGRGTLIIR--DVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLE 513
S G G R D E+ C+ + + G P+ C G F L+
Sbjct: 1564 CSPGFHGYPRCRPCDCHEAGTAPGVCDPLTGQCYCKENVQG-----PKCDQCSLGTFSLD 1618
Query: 514 --HSAACLPCFCFGITSVCQSTRRFRDQ-------IRLRFDQPDDFKGVNVTMPAQPGTP 564
+ C CFCFG T C+S+ R + + L D+ V QPGT
Sbjct: 1619 AANPKGCTRCFCFGATERCRSSSYTRQEFVDMEGWVLLSTDRQV------VPHERQPGTE 1672
Query: 565 PLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRYELAR 624
L + + ++ E + +W P +LG++V SYGG+LRY + E R
Sbjct: 1673 MLRADLRHVPEAVPE----------AFPELYWQAPPSYLGDRVSSYGGTLRYELHSETQR 1722
Query: 625 G-MLEPVQ-RPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVH-ESGRPVQRAE 681
G + P++ RPDVVL G + PG +++ Q+Q E ++ H E+ V R E
Sbjct: 1723 GDVFVPMESRPDVVLQGNQMSITFLEPAYPTPGHVHRGQLQLVEGNFRHTETRNTVSREE 1782
Query: 682 LLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGRAHSVEECRCPIGYSGLS 741
L+ VL SLE + I+ +++ ++V L +A++ + A A +VE C CP Y G S
Sbjct: 1783 LMMVLASLEQLQIRALFSQISSAVFLRRVALEVA-SPAGQGALASNVELCLCPASYRGDS 1841
Query: 742 CESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKCKAGFFG 801
C+ C F R G +LG C C C+GH+ C P G C++CQHNTEG C +C+AGF
Sbjct: 1842 CQECAPGFYRDVKGLFLGRCVPCQCHGHSDRCLPGSGVCVDCQHNTEGAHCERCQAGFVS 1901
Query: 802 DAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGN 861
+A C CPCP S F++ C L G+ C C PGY G CE CAPG+ GN
Sbjct: 1902 SRDDPSA-PCVSCPCPLSVPSNNFAEGCVL-RGGRTQC-LCKPGYAGASCERCAPGFFGN 1958
Query: 862 PIQPGGKCRPVNQEIVRCDERGSMGTS---------GEACR-CKNNVVGRLCNECADGSF 911
P+ G C+P CD G+ + ACR C + G C CA G F
Sbjct: 1959 PLVLGSSCQP-------CDCSGNGDPNLLFSDCDPLTGACRGCLRHTTGPRCEICAPG-F 2010
Query: 912 HLSTRNPDGCLKCFC 926
+ + P C +C C
Sbjct: 2011 YGNALLPGNCTRCDC 2025
Score = 134 bits (336), Expect = 3e-30
Identities = 78/212 (36%), Positives = 100/212 (47%), Gaps = 33/212 (15%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSGLYLGT-CERCSCHGHSEA------CEPETGACQG 1177
QC C PGY G SC+ C G+ P L LG+ C+ C C G+ + C+P TGAC+G
Sbjct: 1936 QCLCKPGYAGASCERCAPGFFGNP--LVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRG 1993
Query: 1178 CQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDAC 1237
C HT GPRCE C PG+YG+A P +C C C P +A D H C
Sbjct: 1994 CLRHTTGPRCEICAPGFYGNAL--LPGNCTRCDC--TPCGTEAC-------DPHSGHCLC 2042
Query: 1238 SPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKA 1297
G +GR C+RC G++G G C+ + P G C PQ +GQC C+
Sbjct: 2043 KAGVTGRRCDRCQEGHFGFDGCGG-CRPCACGPAAEGSECHPQ---------SGQCHCRP 2092
Query: 1298 QVEGLTCSHCRPHHFHLSASNPDGCLPCFCMG 1329
G C C P ++ L GC C C G
Sbjct: 2093 GTMGPQCRECAPGYWGLP---EQGCRRCQCPG 2121
Score = 129 bits (323), Expect = 8e-29
Identities = 161/621 (25%), Positives = 205/621 (33%), Gaps = 184/621 (29%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGT----CSGCNCNGHASSC------------ 773
+C C G +C+ C F + P P C CNC GHA+ C
Sbjct: 321 QCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRAS 380
Query: 774 ---DPVY---GHCLNCQHNTEGPQCNKCKAGFFGDAMKATATS--CRPCPCPYIDASRRF 825
D Y G C++CQH+T G C +C GF+ + CR C C F
Sbjct: 381 QSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNC-----ESDF 435
Query: 826 SDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQ----------- 874
+D D G+ C P ++G RC+ CA G+ G P C P
Sbjct: 436 TDGTCEDLTGRC---YCRPNFSGERCDVCAEGFTGFP-----SCYPTPSSSNDTREQVLP 487
Query: 875 --EIVRCDERGSMGTSGEACR---------CKNNVVGRLCNECADGSFHLSTRNPDGCLK 923
+IV CD + GT G ACR CK N G C CA G + GC
Sbjct: 488 AGQIVNCD-CSAAGTQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFY------GPGCQP 540
Query: 924 CFCMG---VSRHC---TSSSWSRAQLHGASEE---PGHFSLTNAASTHTTNEGIFSPTPG 974
C C C T R GA+ + PG+F + G
Sbjct: 541 CQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCD 600
Query: 975 ELG-------FSSFHRLLSGPYFWSLPS--------RFLGDKVTSYGGELRF------TV 1013
E G F+ H P + P+ R D++ GG R T
Sbjct: 601 EAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCRCRPGYTGTA 660
Query: 1014 TQRSQPGSTPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQPAT 1073
Q PG HG P V + H A +P GQ S RP
Sbjct: 661 CQECSPG---FHGFPSCVPCHCSAEGSLHAACDPRSGQCSC-----------RP------ 700
Query: 1074 REHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPE-------ETGQ--------- 1117
RV+G+ D VP E G
Sbjct: 701 ---------------------------RVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPV 733
Query: 1118 DPALEVEQ--CSCPPGYRGPSCQDCDTGY----TRTPSGLYLGTCERCSCH-----GHSE 1166
DPAL Q C C GPSC C G+ P G C RCSC G
Sbjct: 734 DPALPEAQVPCMCRAHVEGPSCDRCKPGFWGLSPSNPEG-----CTRCSCDLRGTLGGVA 788
Query: 1167 ACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAH---- 1222
C+P TG C C+ H G C C+ G++G + C+ C C A GQ+
Sbjct: 789 ECQPGTGQC-FCKPHVCGQACASCKDGFFG-LDQADYFGCRSCRCDIGGALGQSCEPRTG 846
Query: 1223 --TCFLDTDGHPTCDACSPGH 1241
C +T G PTC + H
Sbjct: 847 VCRCRPNTQG-PTCSEPARDH 866
Score = 114 bits (286), Expect = 2e-24
Identities = 83/274 (30%), Positives = 111/274 (40%), Gaps = 76/274 (27%)
Query: 1096 QPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGT 1155
QP + G++ D P+ TGQ C C G+ G +C C GY P
Sbjct: 539 QPCQCSSPGVADDRCDPD-TGQ--------CRCRVGFEGATCDRCAPGYFHFP------L 583
Query: 1156 CERCSCHGHS---EACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCY 1212
C+ C C E C+ E G C CQ GP C++C+PGY+G +CQ C C
Sbjct: 584 CQLCGCSPAGTLPEGCD-EAGRCL-CQPEFAGPHCDRCRPGYHGFP------NCQACTC- 634
Query: 1213 GDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGP 1272
DP G C G C PG++G C+ C+PG++G PS PC ++ G
Sbjct: 635 -DPR-GALDQLC-----GAGGLCRCRPGYTGTACQECSPGFHGFPSC-VPCHCSAE--GS 684
Query: 1273 IGCNCDPQGSVSS--------------------------QCDAAG-------------QC 1293
+ CDP+ S C AG C
Sbjct: 685 LHAACDPRSGQCSCRPRVTGLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPC 744
Query: 1294 QCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
C+A VEG +C C+P + LS SNP+GC C C
Sbjct: 745 MCRAHVEGPSCDRCKPGFWGLSPSNPEGCTRCSC 778
Score = 113 bits (282), Expect = 5e-24
Identities = 77/284 (27%), Positives = 98/284 (34%), Gaps = 97/284 (34%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTP----SGLYLGTCERCSCHGHSEAC--EPET------ 1172
QC+C G +C C G+ + P + C+ C+C+GH+ C +PE
Sbjct: 321 QCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRAS 380
Query: 1173 ----------GACQGCQHHTEGPRCEQCQPGYYGDAQR--GTPQDCQLCPCYGD------ 1214
G C CQHHT G CE+C PG+Y +P C+ C C D
Sbjct: 381 QSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTC 440
Query: 1215 -----------PAAGQAAHTCFLDTDGHPTC----------------------------- 1234
+G+ C G P+C
Sbjct: 441 EDLTGRCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAG 500
Query: 1235 --------------DACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQ 1280
C P G HCE CAPG+YG QPCQ S PG CDP
Sbjct: 501 TQGNACRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGC--QPCQCSS--PGVADDRCDPD 556
Query: 1281 GSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLP 1324
GQC+C+ EG TC C P +FH GC P
Sbjct: 557 ---------TGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSP 591
Score = 112 bits (281), Expect = 6e-24
Identities = 69/197 (35%), Positives = 95/197 (48%), Gaps = 24/197 (12%)
Query: 1529 ECRCPPGYIGLSCQDCAPGYTRTGSGLYLGH-CELCECNGHSDL------CHPETGACSQ 1581
+C C PGY G SC+ CAPG+ G+ L LG C+ C+C+G+ D C P TGAC
Sbjct: 1936 QCLCKPGYAGASCERCAPGFF--GNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACRG 1993
Query: 1582 CQHNAAGEFCELCAPGYYGDATAG---TPEDCQPCACPLTNPENMFSRTCESLGAGGYRC 1638
C + G CE+CAPG+YG+A T DC PC +P + C++ G G RC
Sbjct: 1994 CLRHTTGPRCEICAPGFYGNALLPGNCTRCDCTPCGTEACDPHSGHC-LCKA-GVTGRRC 2051
Query: 1639 TACEPGYTG-QYCEQCGPGYVGNPSVQGGQCLPETNQ--------APLVVEVHPARSIVP 1689
C+ G+ G C C P G P+ +G +C P++ Q P E P +P
Sbjct: 2052 DRCQEGHFGFDGCGGCRPCACG-PAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLP 2110
Query: 1690 QGGSHSLRCQVSGSPPH 1706
+ G +C PH
Sbjct: 2111 EQGCRRCQCPGGRCDPH 2127
Score = 111 bits (277), Expect = 2e-23
Identities = 87/288 (30%), Positives = 118/288 (40%), Gaps = 48/288 (16%)
Query: 1126 CSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSE---ACEPETGACQGCQHHT 1182
C C PGY G +CQ+C G+ PS C C C AC+P +G C C+
Sbjct: 650 CRCRPGYTGTACQECSPGFHGFPS------CVPCHCSAEGSLHAACDPRSGQCS-CRPRV 702
Query: 1183 EGPRCEQCQPGYYGD--AQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPG 1240
G RC+ C PG Y + G+ L P DPA +A C C
Sbjct: 703 TGLRCDTCVPGAYNFPYCEAGSCHPAGLAPV--DPALPEAQVPCM-----------CRAH 749
Query: 1241 HSGRHCERCAPGYYG-NPSQGQPCQRDSQVPGPIGCNCDPQGSVS--SQCD-AAGQCQCK 1296
G C+RC PG++G +PS + C R C+CD +G++ ++C GQC CK
Sbjct: 750 VEGPSCDRCKPGFWGLSPSNPEGCTR---------CSCDLRGTLGGVAECQPGTGQCFCK 800
Query: 1297 AQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTRHLISTHFAPGDFQGF 1356
V G C+ C+ F L ++ GC C C I S R + + QG
Sbjct: 801 PHVCGQACASCKDGFFGLDQADYFGCRSCRC-DIGGALGQSCEPRTGVCR--CRPNTQGP 857
Query: 1357 ALVNPQRNSRLTG------EFTVEPVPEGAQLSFGNFAQLGHESFYWQ 1398
P R+ L E PEG + FG F L E+F W+
Sbjct: 858 TCSEPARDHYLPDLHHLRLELEEAATPEGHAVRFG-FNPLEFENFSWR 904
Score = 95.9 bits (237), Expect = 8e-19
Identities = 64/193 (33%), Positives = 88/193 (45%), Gaps = 32/193 (16%)
Query: 1512 EVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL 1571
+ + PG ++ + +CRC G+ G +C CAPGY + C+LC C+ L
Sbjct: 542 QCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGY------FHFPLCQLCGCSPAGTL 595
Query: 1572 CH--PETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCE 1629
E G C CQ AG C+ C PGY+G +CQ C C +P + C
Sbjct: 596 PEGCDEAGRCL-CQPEFAGPHCDRCRPGYHGFP------NCQACTC---DPRGALDQLC- 644
Query: 1630 SLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVP 1689
GAGG C PGYTG C++C PG+ G PS C E + +H A P
Sbjct: 645 --GAGGL--CRCRPGYTGTACQECSPGFHGFPSCVPCHCSAEGS-------LHAACD--P 691
Query: 1690 QGGSHSLRCQVSG 1702
+ G S R +V+G
Sbjct: 692 RSGQCSCRPRVTG 704
Score = 95.1 bits (235), Expect = 1e-18
Identities = 69/215 (32%), Positives = 86/215 (40%), Gaps = 60/215 (27%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYL--GTCSGCNCNGHA------SSCDPVYGHCL 781
+C C GY+G SCE C F G P + +C C+C+G+ S CDP+ G C
Sbjct: 1936 QCLCKPGYAGASCERCAPGFF---GNPLVLGSSCQPCDCSGNGDPNLLFSDCDPLTGACR 1992
Query: 782 NCQHNTEGPQCNKCKAGFFGDAM---KATATSCRPCPCPYID-----------ASRRFSD 827
C +T GP+C C GF+G+A+ T C PC D + R D
Sbjct: 1993 GCLRHTTGPRCEICAPGFYGNALLPGNCTRCDCTPCGTEACDPHSGHCLCKAGVTGRRCD 2052
Query: 828 TC---FLDTDGQATCDACA--------------------PGYTGRRCESCAPGYEGNPIQ 864
C DG C CA PG G +C CAPGY G P Q
Sbjct: 2053 RCQEGHFGFDGCGGCRPCACGPAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYWGLPEQ 2112
Query: 865 -------PGGKCRPVNQEIVRCDERGSMGTSGEAC 892
PGG+C P RC+ G SGE C
Sbjct: 2113 GCRRCQCPGGRCDP---HTGRCN--CPPGLSGERC 2142
Score = 91.7 bits (226), Expect = 1e-17
Identities = 73/256 (28%), Positives = 89/256 (34%), Gaps = 75/256 (29%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSG--------------LYLGTCERCSCHG---HSEA 1167
+C C P + G C C G+T PS L G C C A
Sbjct: 446 RCYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNA 505
Query: 1168 C--EPETGAC------QG-----CQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGD 1214
C +P G C QG C GP C+ CQ G A D C C
Sbjct: 506 CRKDPRVGRCLCKPNFQGTHCELCAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCRC--- 562
Query: 1215 PAAGQAAHTCFLDTDGH---PTCD--------------------ACSPGHSGRHCERCAP 1251
G TC G+ P C C P +G HC+RC P
Sbjct: 563 -RVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRP 621
Query: 1252 GYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHH 1311
GY+G P+ CQ C CDP+G++ C A G C+C+ G C C P
Sbjct: 622 GYHGFPN----CQ---------ACTCDPRGALDQLCGAGGLCRCRPGYTGTACQECSP-G 667
Query: 1312 FHLSASNPDGCLPCFC 1327
FH S C+PC C
Sbjct: 668 FHGFPS----CVPCHC 679
Score = 87.8 bits (216), Expect = 2e-16
Identities = 54/173 (31%), Positives = 77/173 (44%), Gaps = 33/173 (19%)
Query: 1158 RCSCHGHSEAC------EPETGACQGCQHHTEGPRCEQCQPGY----YGDAQRGTPQDCQ 1207
RC CHGH++AC +P C CQH+T G C++C PG+ + A + +CQ
Sbjct: 299 RCVCHGHADACDAKDPTDPFRLQCT-CQHNTCGGTCDRCCPGFNQQPWKPATANSANECQ 357
Query: 1208 LCPCYG-------DPAAGQAAHTCFLD--TDGHPTCDACSPGHSGRHCERCAPGYYGNPS 1258
C CYG DP + + LD G C C +G +CERC PG+Y +P+
Sbjct: 358 SCNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPN 417
Query: 1259 ----QGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHC 1307
C+R CNC+ + + D G+C C+ G C C
Sbjct: 418 HPLDSPHVCRR---------CNCESDFTDGTCEDLTGRCYCRPNFSGERCDVC 461
Score = 83.6 bits (205), Expect = 4e-15
Identities = 59/205 (28%), Positives = 78/205 (38%), Gaps = 43/205 (20%)
Query: 728 VEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHA---SSCDPVYGHCLNCQ 784
V C C + G CE C F Y C C C+ CDP G C C+
Sbjct: 512 VGRCLCKPNFQGTHCELCAPGF-------YGPGCQPCQCSSPGVADDRCDPDTGQC-RCR 563
Query: 785 HNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAP 844
EG C++C G+F + C+ C C + + C D C C P
Sbjct: 564 VGFEGATCDRCAPGYFHFPL------CQLCGC---SPAGTLPEGC----DEAGRC-LCQP 609
Query: 845 GYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGT---SGEACRCKNNVVGR 901
+ G C+ C PGY G P N + CD RG++ +G CRC+ G
Sbjct: 610 EFAGPHCDRCRPGYHGFP----------NCQACTCDPRGALDQLCGAGGLCRCRPGYTGT 659
Query: 902 LCNECADGSFHLSTRNPDGCLKCFC 926
C EC+ G FH C+ C C
Sbjct: 660 ACQECSPG-FH----GFPSCVPCHC 679
Score = 80.1 bits (196), Expect = 4e-14
Identities = 52/199 (26%), Positives = 77/199 (38%), Gaps = 42/199 (21%)
Query: 1529 ECRCPPGYIGLSCQDCAPGYT----RTGSGLYLGHCELCECNGHSDLCH--PET------ 1576
+C C G +C C PG+ + + C+ C C GH+ C+ PE
Sbjct: 321 QCTCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQSCNCYGHATDCYYDPEVDRRRAS 380
Query: 1577 ----------GACSQCQHNAAGEFCELCAPGYYGDAT--AGTPEDCQPCACPLTNPENMF 1624
G C CQH+ G CE C PG+Y +P C+ C C +
Sbjct: 381 QSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPNHPLDSPHVCRRCNC----ESDFT 436
Query: 1625 SRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPA 1684
TCE L Y C P ++G+ C+ C G+ G PS C P + + E
Sbjct: 437 DGTCEDLTGRCY----CRPNFSGERCDVCAEGFTGFPS-----CYPTPSSSNDTRE---- 483
Query: 1685 RSIVPQGGSHSLRCQVSGS 1703
++P G + C +G+
Sbjct: 484 -QVLPAGQIVNCDCSAAGT 501
Score = 75.1 bits (183), Expect = 1e-12
Identities = 58/172 (33%), Positives = 73/172 (42%), Gaps = 33/172 (19%)
Query: 764 CNCNGHASSC------DPVYGHCLNCQHNTEGPQCNKCKAGFFGDAMK-ATATS---CRP 813
C C+GHA +C DP C CQHNT G C++C GF K ATA S C+
Sbjct: 300 CVCHGHADACDAKDPTDPFRLQC-TCQHNTCGGTCDRCCPGFNQQPWKPATANSANECQS 358
Query: 814 CPC----------PYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPI 863
C C P +D RR S + G C C TG CE C PG+ +P
Sbjct: 359 CNCYGHATDCYYDPEVD-RRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPN 417
Query: 864 QPGGK---CRPVNQEIVRCDERGSMGTSGE---ACRCKNNVVGRLCNECADG 909
P CR N C+ + GT + C C+ N G C+ CA+G
Sbjct: 418 HPLDSPHVCRRCN-----CESDFTDGTCEDLTGRCYCRPNFSGERCDVCAEG 464
Score = 70.9 bits (172), Expect = 3e-11
Identities = 51/166 (30%), Positives = 62/166 (37%), Gaps = 46/166 (27%)
Query: 1530 CRCPPGYIGLSCQDCAPGYTRTGSG--------------LYLGHCELCECN-----GHSD 1570
C C P + G C CA G+T S L G C+C+ G++
Sbjct: 447 CYCRPNFSGERCDVCAEGFTGFPSCYPTPSSSNDTREQVLPAGQIVNCDCSAAGTQGNAC 506
Query: 1571 LCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCES 1630
P G C C+ N G CELCAPG+YG CQPC C S
Sbjct: 507 RKDPRVGRCL-CKPNFQGTHCELCAPGFYGPG-------CQPC-------------QCSS 545
Query: 1631 LGAGGYRC------TACEPGYTGQYCEQCGPGYVGNPSVQGGQCLP 1670
G RC C G+ G C++C PGY P Q C P
Sbjct: 546 PGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSP 591
Score = 68.9 bits (167), Expect = 1e-10
Identities = 50/149 (33%), Positives = 66/149 (44%), Gaps = 29/149 (19%)
Query: 731 CRCPIGYSGLSCESC-DAHFTRVPGGPYLGTCSGCNCNGHA--SSCDPVYGHCLNCQHNT 787
C C G +G C+ C + HF G G C C C A S C P G C +C+ T
Sbjct: 2040 CLCKAGVTGRRCDRCQEGHF----GFDGCGGCRPCACGPAAEGSECHPQSGQC-HCRPGT 2094
Query: 788 EGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYT 847
GPQC +C G++G CR C CP C T C+ C PG +
Sbjct: 2095 MGPQCRECAPGYWG----LPEQGCRRCQCP--------GGRCDPHT---GRCN-CPPGLS 2138
Query: 848 GRRCESCAPGYEGNPIQPGGKCRPVNQEI 876
G RC++C+ ++ P+ PGG PV I
Sbjct: 2139 GERCDTCSQQHQ-VPV-PGG---PVGHSI 2162
Score = 66.6 bits (161), Expect = 5e-10
Identities = 41/119 (34%), Positives = 56/119 (47%), Gaps = 20/119 (16%)
Query: 1563 CECNGHSDLC------HPETGACSQCQHNAAGEFCELCAPGY----YGDATAGTPEDCQP 1612
C C+GH+D C P C+ CQHN G C+ C PG+ + ATA + +CQ
Sbjct: 300 CVCHGHADACDAKDPTDPFRLQCT-CQHNTCGGTCDRCCPGFNQQPWKPATANSANECQS 358
Query: 1613 CAC------PLTNPENMFSRTCESLGA---GGYRCTACEPGYTGQYCEQCGPGYVGNPS 1662
C C +PE R +SL GG C C+ TG CE+C PG+ +P+
Sbjct: 359 CNCYGHATDCYYDPEVDRRRASQSLDGTYQGGGVCIDCQHHTTGVNCERCLPGFYRSPN 417
Score = 65.1 bits (157), Expect = 1e-09
Identities = 46/180 (25%), Positives = 64/180 (35%), Gaps = 62/180 (34%)
Query: 1530 CRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL---CHPETGACS------ 1580
CRC PGY G +CQ+C+PG+ S C C C+ L C P +G CS
Sbjct: 650 CRCRPGYTGTACQECSPGFHGFPS------CVPCHCSAEGSLHAACDPRSGQCSCRPRVT 703
Query: 1581 -----------------------------------------QCQHNAAGEFCELCAPGYY 1599
C+ + G C+ C PG++
Sbjct: 704 GLRCDTCVPGAYNFPYCEAGSCHPAGLAPVDPALPEAQVPCMCRAHVEGPSCDRCKPGFW 763
Query: 1600 GDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVG 1659
G + PE C C+C L + C+ G +C C+P GQ C C G+ G
Sbjct: 764 G-LSPSNPEGCTRCSCDLRGTLGGVAE-CQ---PGTGQC-FCKPHVCGQACASCKDGFFG 817
Score = 57.0 bits (136), Expect = 4e-07
Identities = 30/79 (37%), Positives = 36/79 (45%), Gaps = 7/79 (8%)
Query: 1112 PEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPE 1171
P G + + QC C PG GP C++C GY GL C RC C G C+P
Sbjct: 2074 PAAEGSECHPQSGQCHCRPGTMGPQCRECAPGYW----GLPEQGCRRCQCPG--GRCDPH 2127
Query: 1172 TGACQGCQHHTEGPRCEQC 1190
TG C C G RC+ C
Sbjct: 2128 TGRC-NCPPGLSGERCDTC 2145
Score = 48.9 bits (115), Expect = 1e-04
Identities = 45/171 (26%), Positives = 80/171 (46%), Gaps = 23/171 (13%)
Query: 4199 PGQYGAYFHDDG---FLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQ 4255
P + G +F G L PG +LP+V +ELEVR +GL+ +G+A +
Sbjct: 3517 PLEAGLFFPGSGGVITLDLPG----ATLPDVG--LELEVRPLAVTGLIF----HLGQA-R 3565
Query: 4256 GKDFISLGLQDGHLVFRYQLGSGEARLVSEDP--INDGEWHRVTALREGRRGSIQVDGEE 4313
++ L + + ++ R G+GE P + DG+WHR+ ++ G ++VD +
Sbjct: 3566 TPPYLQLQVTEKQVLLRADDGAGEFSTSVTRPSVLCDGQWHRLAVMKSGNVLRLEVDAQ- 3624
Query: 4314 LVSGRSPGP--NVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVLH 4362
S + GP A A +Y+GG P+ + + GC++ L ++
Sbjct: 3625 --SNHTVGPLLAAAAGAPAPLYLGGLPEPMAVQ--PWPPAYCGCMRRLAVN 3671
Score = 48.1 bits (113), Expect = 2e-04
Identities = 38/114 (33%), Positives = 43/114 (37%), Gaps = 17/114 (14%)
Query: 4072 HFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLC 4131
H C+ + V G+R D G G C PC P G+ C P QC C
Sbjct: 2036 HSGHCLCKAGVTGRRCDRCQE--GHFGFDGCGGCRPCACGPAAEGSECHPQSG---QCHC 2090
Query: 4132 RDGFKGDLCEH--------EENPCQLREPCLHGGTCQGT--RCLCLPGFSGPRC 4175
R G G C E C+ R C GG C RC C PG SG RC
Sbjct: 2091 RPGTMGPQCRECAPGYWGLPEQGCR-RCQC-PGGRCDPHTGRCNCPPGLSGERC 2142
Score = 46.6 bits (109), Expect = 5e-04
Identities = 37/144 (25%), Positives = 59/144 (40%), Gaps = 7/144 (4%)
Query: 4229 TIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPI 4288
++ + V ++ GLLL+ G ++L L +GH V + + R S
Sbjct: 3365 SLSMHVLPRSSRGLLLF----TARLRPGSPSLALFLSNGHFVAQMEGLGTRLRAQSRQRS 3420
Query: 4289 NDGEWHRVTALREGRRGSIQVDGEELVSGRSP---GPNVAVNAKGSVYIGGAPDVATLTG 4345
G WH+V+ E R + DG S P ++++GG P + +
Sbjct: 3421 RPGRWHKVSVRWEKNRILLVTDGARAWSQEGPHRQHQGAEHPQPHTLFVGGLPASSHSSK 3480
Query: 4346 GRFSSGITGCVKNLVLHSARPGAP 4369
+ G +GCVK L LH GAP
Sbjct: 3481 LPVTVGFSGCVKRLRLHGRPLGAP 3504
Score = 46.2 bits (108), Expect = 7e-04
Identities = 31/88 (35%), Positives = 36/88 (40%), Gaps = 13/88 (14%)
Query: 3844 HCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALH--------CHPEACGP 3895
+C C PC G + D S C+C AG TG RC+ Q H C P ACGP
Sbjct: 2019 NCTRCDCTPC--GTEACDPHSGH--CLCKAGVTGRRCDRCQEGHFGFDGCGGCRPCACGP 2074
Query: 3896 DATCVNRPDGRGYTCRCHLGRSGLRCEE 3923
A G C C G G +C E
Sbjct: 2075 AAEGSECHPQSG-QCHCRPGTMGPQCRE 2101
Score = 44.7 bits (104), Expect = 0.002
Identities = 41/156 (26%), Positives = 50/156 (32%), Gaps = 38/156 (24%)
Query: 1560 CELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDC--------- 1610
C E C P G C C + G C CA GY+G P DC
Sbjct: 1438 CGCHEVGATGPTCEPFGGQCP-CHAHVIGRDCSRCATGYWGFPNC-RPCDCGARLCDELT 1495
Query: 1611 QPCACP---------LTNPEN------MFSRTCESLGAGGYRCT-----------ACEPG 1644
C CP L P+ + C G G T C P
Sbjct: 1496 GQCICPPRTIPPDCLLCQPQTFGCHPLVGCEECNCSGPGIQELTDPTCDTDSGQCKCRPN 1555
Query: 1645 YTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVE 1680
TG+ C+ C PG+ G P + C E AP V +
Sbjct: 1556 VTGRRCDTCSPGFHGYPRCRPCDC-HEAGTAPGVCD 1590
Score = 44.3 bits (103), Expect = 0.003
Identities = 29/98 (29%), Positives = 38/98 (38%), Gaps = 10/98 (10%)
Query: 1245 HCERCAPGYYGNPSQGQPCQRDSQVP-------GPIGCNCDPQGSVSSQCDA-AGQCQCK 1296
HC A GY+ +PS R++ G C C G+ C+ GQC C
Sbjct: 1403 HC--AAQGYHISPSSSSLFCRNAAASLSLFYNNGARPCGCHEVGATGPTCEPFGGQCPCH 1460
Query: 1297 AQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQC 1334
A V G CS C ++ P C C +T QC
Sbjct: 1461 AHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQC 1498
Score = 43.5 bits (101), Expect = 0.005
Identities = 24/74 (32%), Positives = 31/74 (41%), Gaps = 5/74 (6%)
Query: 1529 ECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL---CHPETGACSQCQHN 1585
+C C P G +C C G+ Y G C C C+ L C P TG C +C+ N
Sbjct: 796 QCFCKPHVCGQACASCKDGFFGLDQADYFG-CRSCRCDIGGALGQSCEPRTGVC-RCRPN 853
Query: 1586 AAGEFCELCAPGYY 1599
G C A +Y
Sbjct: 854 TQGPTCSEPARDHY 867
Score = 41.2 bits (95), Expect = 0.023
Identities = 34/140 (24%), Positives = 58/140 (41%), Gaps = 28/140 (20%)
Query: 4055 GGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTY-SFLGSQGI-GQCY--DSSPCER 4110
G +P++ S ++ RGC+ + G R ++ F G+ + G C D +PC
Sbjct: 1973 GNGDPNLLFSDCDPLTGACRGCLRHTT--GPRCEICAPGFYGNALLPGNCTRCDCTPCGT 2030
Query: 4111 QPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEE------NPCQLREPCLHGGTCQGT-- 4162
+ C + CLC+ G G C+ + + C PC G +G+
Sbjct: 2031 EACD---------PHSGHCLCKAGVTGRRCDRCQEGHFGFDGCGGCRPCACGPAAEGSEC 2081
Query: 4163 -----RCLCLPGFSGPRCQQ 4177
+C C PG GP+C++
Sbjct: 2082 HPQSGQCHCRPGTMGPQCRE 2101
Score = 40.4 bits (93), Expect = 0.039
Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 14/114 (12%)
Query: 4076 CVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRD-G 4134
C + +G+R D+ G G CY + + +PAG+ C C G
Sbjct: 447 CYCRPNFSGERCDVCAE--GFTGFPSCYPTPSSSNDTREQ---VLPAGQI-VNCDCSAAG 500
Query: 4135 FKGDLCEHEENPCQLREPCLHGGTCQGTRC-LCLPGFSGPRCQ--QGSGHGIAE 4185
+G+ C + + CL QGT C LC PGF GP CQ Q S G+A+
Sbjct: 501 TQGNACRKDPRVGR----CLCKPNFQGTHCELCAPGFYGPGCQPCQCSSPGVAD 550
Score = 40.4 bits (93), Expect = 0.039
Identities = 26/89 (29%), Positives = 38/89 (42%), Gaps = 4/89 (4%)
Query: 3839 AHGISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQ-ALHCHP--EACGP 3895
A G H P C+ C G + + C+C F G C+ + H P +AC
Sbjct: 575 APGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPHCDRCRPGYHGFPNCQACTC 634
Query: 3896 DAT-CVNRPDGRGYTCRCHLGRSGLRCEE 3923
D +++ G G CRC G +G C+E
Sbjct: 635 DPRGALDQLCGAGGLCRCRPGYTGTACQE 663
Score = 40.4 bits (93), Expect = 0.039
Identities = 25/88 (28%), Positives = 35/88 (39%), Gaps = 8/88 (9%)
Query: 3840 HGISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEH-SQALH----CHPEACG 3894
HG +C C C G + +C C G+TG+ C+ S H C P C
Sbjct: 624 HGFPNCQACT---CDPRGALDQLCGAGGLCRCRPGYTGTACQECSPGFHGFPSCVPCHCS 680
Query: 3895 PDATCVNRPDGRGYTCRCHLGRSGLRCE 3922
+ + D R C C +GLRC+
Sbjct: 681 AEGSLHAACDPRSGQCSCRPRVTGLRCD 708
Score = 38.5 bits (88), Expect = 0.15
Identities = 41/167 (24%), Positives = 71/167 (42%), Gaps = 20/167 (11%)
Query: 3934 GAGSYLALPALTNTHHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRY 3993
G+G + L T ++ L++E +PLA G++ G P ++ L + + R
Sbjct: 3526 GSGGVITLDLPGATLPDVGLELEVRPLAVTGLIFHLGQARTP--PYLQLQVTEKQVLLRA 3583
Query: 3994 ELGSGLAVLRSAEPLAL--GRWHRVSAE------RLNKDGSLRVNGGRPVLRSSPGKSQG 4045
+ G+G P L G+WHR++ RL D G P+L ++ G
Sbjct: 3584 DDGAGEFSTSVTRPSVLCDGQWHRLAVMKSGNVLRLEVDAQSNHTVG-PLLAAAAGAP-- 3640
Query: 4046 LNLHTLLYLGGVEPSVPLSPATNMSAHFRGCVGEVSVNGKRLDLTYS 4092
LYLGG+ + + P + GC+ ++VN + +T S
Sbjct: 3641 ----APLYLGGLPEPMAVQP---WPPAYCGCMRRLAVNRSPVAMTRS 3680
Score = 37.7 bits (86), Expect = 0.25
Identities = 40/140 (28%), Positives = 66/140 (47%), Gaps = 9/140 (6%)
Query: 3953 LDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYE-LGSGLAVLRSAEPLALG 4011
L + P + G+LLF+ + P ++L + GH + E LG+ L +S + G
Sbjct: 3366 LSMHVLPRSSRGLLLFTA-RLRPGSPSLALFLSNGHFVAQMEGLGTRLRA-QSRQRSRPG 3423
Query: 4012 RWHRVSAERLNKDGSLRVNGGRPVLRSSPGKS-QGL---NLHTLLYLGGVEPSVPLSPAT 4067
RWH+VS L +G R + P + QG HT L++GG+ P+ S
Sbjct: 3424 RWHKVSVRWEKNRILLVTDGARAWSQEGPHRQHQGAEHPQPHT-LFVGGL-PASSHSSKL 3481
Query: 4068 NMSAHFRGCVGEVSVNGKRL 4087
++ F GCV + ++G+ L
Sbjct: 3482 PVTVGFSGCVKRLRLHGRPL 3501
Score = 37.4 bits (85), Expect = 0.33
Identities = 23/61 (37%), Positives = 28/61 (45%), Gaps = 12/61 (19%)
Query: 4128 QCLCRDGFKGDLCEH------EENPCQLREPCLHGGTC-----QGTRCLCLPGFSGPRCQ 4176
QC CR GF+G C+ CQL C GT + RCLC P F+GP C
Sbjct: 559 QCRCRVGFEGATCDRCAPGYFHFPLCQLCG-CSPAGTLPEGCDEAGRCLCQPEFAGPHCD 617
Query: 4177 Q 4177
+
Sbjct: 618 R 618
Score = 36.6 bits (83), Expect = 0.56
Identities = 23/68 (33%), Positives = 29/68 (42%), Gaps = 20/68 (29%)
Query: 1529 ECR-CPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAA 1587
+CR C PGY GL Q C C+C G C P TG C+ C +
Sbjct: 2098 QCRECAPGYWGLPEQG----------------CRRCQCPG--GRCDPHTGRCN-CPPGLS 2138
Query: 1588 GEFCELCA 1595
GE C+ C+
Sbjct: 2139 GERCDTCS 2146
Score = 36.2 bits (82), Expect = 0.74
Identities = 20/52 (38%), Positives = 25/52 (48%), Gaps = 12/52 (23%)
Query: 731 CRCPIGYSGLSCESC-DAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCL 781
C CP G SG C++C H VPGGP GH+ C+ V HC+
Sbjct: 2131 CNCPPGLSGERCDTCSQQHQVPVPGGPV----------GHSIHCE-VCDHCV 2171
Score = 33.9 bits (76), Expect = 3.7
Identities = 41/134 (30%), Positives = 48/134 (35%), Gaps = 39/134 (29%)
Query: 4062 PLSPATNMSA----------HFRGCVGEVSVNGKR----LDLTYSFLGSQGIGQCYDSSP 4107
P PAT SA H C + V+ +R LD TY QG G C D
Sbjct: 344 PWKPATANSANECQSCNCYGHATDCYYDPEVDRRRASQSLDGTY-----QGGGVCID--- 395
Query: 4108 CERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLR----EPCLHGGTCQGT- 4162
CQH T + C GF ++P R E GTC+
Sbjct: 396 -----CQHHTTGVNCER------CLPGFYRSPNHPLDSPHVCRRCNCESDFTDGTCEDLT 444
Query: 4163 -RCLCLPGFSGPRC 4175
RC C P FSG RC
Sbjct: 445 GRCYCRPNFSGERC 458
Score = 33.9 bits (76), Expect = 3.7
Identities = 18/59 (30%), Positives = 26/59 (44%), Gaps = 4/59 (6%)
Query: 879 CDERGSMGTS----GEACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHC 933
C E G+ G + G C C +V+GR C+ CA G + P C C ++ C
Sbjct: 1440 CHEVGATGPTCEPFGGQCPCHAHVIGRDCSRCATGYWGFPNCRPCDCGARLCDELTGQC 1498
Score = 33.9 bits (76), Expect = 3.7
Identities = 39/180 (21%), Positives = 74/180 (41%), Gaps = 28/180 (15%)
Query: 3674 LPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRP 3733
LP T+ D + E+ RP + G++ + GQ R P ++ + +
Sbjct: 3535 LPGATLPDVGLELEV----RPLAVTGLIFHLGQART-----------PPYLQLQVTEKQV 3579
Query: 3734 EFRFDAGSG--MATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKF--QG 3789
R D G+G ++ P+ L G +H + +++S G+++ ++ + + G
Sbjct: 3580 LLRADDGAGEFSTSVTRPSVLCDGQWHRLAVMKS---GNVLRLEVDAQSNHTVGPLLAAA 3636
Query: 3790 LDLNEELYLGGYPDYGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAH---GISHCP 3846
LYLGG P+ A+ + GC+R L + + ++ H G S CP
Sbjct: 3637 AGAPAPLYLGGLPEPMAVQP--WPPAYCGCMRRLAVNRSPVAM-TRSVEVHGAVGASGCP 3693
Score = 33.5 bits (75), Expect = 4.8
Identities = 32/115 (27%), Positives = 45/115 (39%), Gaps = 42/115 (36%)
Query: 4100 GQC-----YDSSPCERQPCQHG---------ATCMPAG------EYEFQCLCRDGFKGDL 4139
GQC ++ + C+R C G C PAG + +CLC+ F G
Sbjct: 558 GQCRCRVGFEGATCDR--CAPGYFHFPLCQLCGCSPAGTLPEGCDEAGRCLCQPEFAGPH 615
Query: 4140 CE------HEENPCQ---------LREPCLHGGTCQGTRCLCLPGFSGPRCQQGS 4179
C+ H CQ L + C GG C+ C PG++G CQ+ S
Sbjct: 616 CDRCRPGYHGFPNCQACTCDPRGALDQLCGAGGLCR-----CRPGYTGTACQECS 665
Score = 33.5 bits (75), Expect = 4.8
Identities = 30/105 (28%), Positives = 41/105 (39%), Gaps = 25/105 (23%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRG 3907
CR C GG+C C CP G +G RC+ H P GP G
Sbjct: 2114 CRRCQCP-GGRCDPHTGR---CNCPPGLSGERCDTCSQQHQVPVPGGP----------VG 2159
Query: 3908 YTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNTHHELR 3952
++ C + C+ V + L AG+ LPA+ H +LR
Sbjct: 2160 HSIHCEV------CDHCVVLLLDDLERAGA--LLPAI---HEQLR 2193
Score = 33.1 bits (74), Expect = 6.2
Identities = 17/58 (29%), Positives = 22/58 (37%), Gaps = 4/58 (6%)
Query: 3869 CVCPAGFTGSRCEHSQ----ALHCHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCE 3922
C+C F G+ CE C P C +R D CRC +G G C+
Sbjct: 515 CLCKPNFQGTHCELCAPGFYGPGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCD 572
Score = 33.1 bits (74), Expect = 6.2
Identities = 23/90 (25%), Positives = 33/90 (36%), Gaps = 17/90 (18%)
Query: 3846 PTCRDRPCQNGGQCHDS-ESSSYVCVCPAGFTGSRCEHSQALHCH--------------- 3889
P C+ C + G D + + C C GF G+ C+ + H
Sbjct: 536 PGCQPCQCSSPGVADDRCDPDTGQCRCRVGFEGATCDRCAPGYFHFPLCQLCGCSPAGTL 595
Query: 3890 PEACGPDATCVNRPDGRGYTC-RCHLGRSG 3918
PE C C+ +P+ G C RC G G
Sbjct: 596 PEGCDEAGRCLCQPEFAGPHCDRCRPGYHG 625
Score = 32.7 bits (73), Expect = 8.2
Identities = 27/92 (29%), Positives = 31/92 (33%), Gaps = 18/92 (19%)
Query: 3841 GISHCPTCRD---RPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACG-PD 3896
G C CR P G +CH C C G G +C C P G P+
Sbjct: 2060 GFDGCGGCRPCACGPAAEGSECHPQSGQ---CHCRPGTMGPQCR-----ECAPGYWGLPE 2111
Query: 3897 ATC------VNRPDGRGYTCRCHLGRSGLRCE 3922
C R D C C G SG RC+
Sbjct: 2112 QGCRRCQCPGGRCDPHTGRCNCPPGLSGERCD 2143
>gi|38045910 laminin alpha 3 subunit isoform 1 [Homo sapiens]
Length = 3333
Score = 313 bits (803), Expect = 2e-84
Identities = 200/566 (35%), Positives = 260/566 (45%), Gaps = 63/566 (11%)
Query: 1115 TGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGA 1174
TG + E QC C P G C C TG+ P C+ CSC CE TG
Sbjct: 1274 TGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPR------CKPCSCG--RRLCEEMTGQ 1325
Query: 1175 CQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTC 1234
C+ C T P+CE C+ + C+ C C A C D+ C
Sbjct: 1326 CR-CPPRTVRPQCEVCETHSFSFHPMA---GCEGCNCSRRGTIEAAMPECDRDSG---QC 1378
Query: 1235 DACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCD-AAGQC 1293
C P +GR C+RCA G+Y + P + CNC+ G+ CD G C
Sbjct: 1379 -RCKPRITGRQCDRCASGFY-------------RFPECVPCNCNRDGTEPGVCDPGTGAC 1424
Query: 1294 QCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTR----HLISTHFA 1349
CK VEG C+ CR FHL +N GC CFC G+ QC SS R ++ H
Sbjct: 1425 LCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLE 1484
Query: 1350 PGDFQGFAL-VNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKV 1408
D + NP NS + ++ +P S W P +Y GDKV
Sbjct: 1485 TADRVDIPVSFNPGSNSMVAD---LQELPATIH------------SASWVAPTSYLGDKV 1529
Query: 1409 AAYGGKLRYTLSYTAGPQGSPLSD--PDVQITGNNIMLVASQPALQGPERRSYEIMFREE 1466
++YGG L Y P L + PDVQ+TG ++ ++ + P+R + + E
Sbjct: 1530 SSYGGYLTYQAKSFGLPGDMVLLEKKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVE 1589
Query: 1467 --FWRRPDGQPATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNRPRA 1524
F P +RE L+ L+ L ++ I+ + + ++S V LE A S R A
Sbjct: 1590 GNFRHASSRAPVSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRI-A 1648
Query: 1525 LEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQH 1584
L VE C CPP Y G SCQ C+PGY R GLY G C C CNGHS+ C +G C CQH
Sbjct: 1649 LAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQH 1708
Query: 1585 NAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPG 1644
N AGE CE C GYYG+A G+ C+ C CP T N F+ C + G RC +C+ G
Sbjct: 1709 NTAGEHCERCQEGYYGNAVHGS---CRACPCPHT---NSFATGC-VVNGGDVRC-SCKAG 1760
Query: 1645 YTGQYCEQCGPGYVGNPSVQGGQCLP 1670
YTG CE+C PGY GNP GG C P
Sbjct: 1761 YTGTQCERCAPGYFGNPQKFGGSCQP 1786
Score = 271 bits (694), Expect = 8e-72
Identities = 184/569 (32%), Positives = 249/569 (43%), Gaps = 52/569 (9%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEG 789
+C C G C C P C C+C C+ + G C C T
Sbjct: 1284 QCPCQPNVIGRQCTRCATGHYGFP------RCKPCSCGRRL--CEEMTGQC-RCPPRTVR 1334
Query: 790 PQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGR 849
PQC C+ F A C C C C D+ GQ C P TGR
Sbjct: 1335 PQCEVCETHSFSFHPMA---GCEGCNCSRRGTIEAAMPECDRDS-GQCRCK---PRITGR 1387
Query: 850 RCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADG 909
+C+ CA G+ P C E CD GT AC CK NV G CN C +G
Sbjct: 1388 QCDRCASGFYRFPECVPCNCNRDGTEPGVCDP----GTG--ACLCKENVEGTECNVCREG 1441
Query: 910 SFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAASTHTTNEGIF 969
SFHL N GC CFC GV+ C SS R + H + + F
Sbjct: 1442 SFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKF--VDMLGWHLETADRVDIPVS----F 1495
Query: 970 SPTPGELGFSSFHRLLSGPYF--WSLPSRFLGDKVTSYGGELRFTVTQRSQPGS-TPLHG 1026
+P + + L + + W P+ +LGDKV+SYGG L + PG L
Sbjct: 1496 NPGSNSM-VADLQELPATIHSASWVAPTSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLEK 1554
Query: 1027 QPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQ-PATREHLLMALAGID 1085
+P V L G ++ + + P P + V E ++ + P +RE L+ L+ +
Sbjct: 1555 KPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELMTVLSRLA 1614
Query: 1086 TLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYT 1145
+ I+ Y + +S + ++ A +G+ AL VE C+CPP Y G SCQ C GY
Sbjct: 1615 DVRIQGLYFTETQRLTLSEVGLEEASDTGSGR-IALAVEICACPPAYAGDSCQGCSPGYY 1673
Query: 1146 RTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQD 1205
R GLY G C C+C+GHS C+ +G C CQH+T G CE+CQ GYYG+A G+
Sbjct: 1674 RDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGS--- 1730
Query: 1206 CQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQ-GQPCQ 1264
C+ CPC P A C ++ G C +C G++G CERCAPGY+GNP + G CQ
Sbjct: 1731 CRACPC---PHTNSFATGCVVN-GGDVRC-SCKAGYTGTQCERCAPGYFGNPQKFGGSCQ 1785
Query: 1265 RDSQVPGPIGCNCDPQGSVSSQCDAAGQC 1293
C+C+ G + S G C
Sbjct: 1786 ---------PCSCNSNGQLGSCHPLTGDC 1805
Score = 228 bits (581), Expect = 1e-58
Identities = 133/392 (33%), Positives = 203/392 (51%), Gaps = 41/392 (10%)
Query: 505 CPDGHFYLEHS--AACLPCFCFGITSVCQSTRR----FRDQIRLRFDQPDDFKGVNVTMP 558
C +G F+L+ + C CFCFG+ + C S+ + F D + + D V++ +
Sbjct: 1438 CREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETADR---VDIPVS 1494
Query: 559 AQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNV 618
PG+ + + ++ + +H + W P +LG+KV SYGG L Y
Sbjct: 1495 FNPGSNSMVADLQELPAT--------------IHSASWVAPTSYLGDKVSSYGGYLTYQA 1540
Query: 619 R-YELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGR-P 676
+ + L M+ ++PDV L G ++ +P L+ +V E ++ H S R P
Sbjct: 1541 KSFGLPGDMVLLEKKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAP 1600
Query: 677 VQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGR-AHSVEECRCPI 735
V R EL+ VL L V IQ +Y T+ + LS++ ++ T GR A +VE C CP
Sbjct: 1601 VSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASD--TGSGRIALAVEICACPP 1658
Query: 736 GYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKC 795
Y+G SC+ C + R G Y G C CNCNGH++ C G C+NCQHNT G C +C
Sbjct: 1659 AYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERC 1718
Query: 796 KAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCA 855
+ G++G+A+ SCR CPCP+ ++ F+ C ++ G C +C GYTG +CE CA
Sbjct: 1719 QEGYYGNAVHG---SCRACPCPHTNS---FATGCVVN-GGDVRC-SCKAGYTGTQCERCA 1770
Query: 856 PGYEGNPIQPGGKCRPVNQEIVRCDERGSMGT 887
PGY GNP + GG C+P + C+ G +G+
Sbjct: 1771 PGYFGNPQKFGGSCQPCS-----CNSNGQLGS 1797
Score = 113 bits (282), Expect = 5e-24
Identities = 75/238 (31%), Positives = 95/238 (39%), Gaps = 46/238 (19%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYT----RTPSGLYLGTCERCSCHGHSEAC--EPET------ 1172
+C C G +C C TGY R + CE C+CHGH+ C +P+
Sbjct: 318 RCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQAS 377
Query: 1173 ----------GACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQ--LCPCYGDPAAGQA 1220
G C CQH+T G CEQC GYY G P D PC DP +
Sbjct: 378 LNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYY--RPYGVPVDAPDGCIPCSCDP---EH 432
Query: 1221 AHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNP--------SQGQPCQRDSQVPGP 1272
A C G C C P G +CE+CA GYY P P D
Sbjct: 433 ADGC---EQGSGRCH-CKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDI 488
Query: 1273 IGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGI 1330
GC+C+ +G + CDA G+C C+ VEG C CR + C C+C +
Sbjct: 489 KGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPI-----CQACWCSAL 541
Score = 108 bits (269), Expect = 2e-22
Identities = 72/221 (32%), Positives = 95/221 (42%), Gaps = 47/221 (21%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSGLYL---------------GTCERCSCHGHS---E 1166
+C C P + G +C+ C GY P L + G + C C+ E
Sbjct: 442 RCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPE 501
Query: 1167 ACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFL 1226
C+ G C C+ EGPRC+ C+ G+Y CQ C C A G C
Sbjct: 502 ICDAH-GRCL-CRPGVEGPRCDTCRSGFYSFPI------CQACWC---SALGSYQMPCSS 550
Query: 1227 DTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQ 1286
T C+ C PG +G+ C+RC G Y P CQ S CDP G+++S
Sbjct: 551 VTG---QCE-CRPGVTGQRCDRCLSGAYDFPH----CQGSSSA-------CDPAGTINSN 595
Query: 1287 CDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
G CQCK VEG TCS C+ +++L NP GC C C
Sbjct: 596 L---GYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKC 633
Score = 90.5 bits (223), Expect = 3e-17
Identities = 62/214 (28%), Positives = 91/214 (42%), Gaps = 41/214 (19%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVP---------------GGPYLGTCSGCNCNGHA---SS 772
C C + G +CE C + P P G GC+CN
Sbjct: 443 CHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEI 502
Query: 773 CDPVYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLD 832
CD +G CL C+ EGP+C+ C++GF+ + C+ C C + + + C
Sbjct: 503 CD-AHGRCL-CRPGVEGPRCDTCRSGFYSFPI------CQACWCSALGS---YQMPCSSV 551
Query: 833 TDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEAC 892
T GQ C+ C PG TG+RC+ C G P G CD G++ ++ C
Sbjct: 552 T-GQ--CE-CRPGVTGQRCDRCLSGAYDFPHCQGSSSA--------CDPAGTINSNLGYC 599
Query: 893 RCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFC 926
+CK +V G C+ C ++L NP GC +C C
Sbjct: 600 QCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKC 633
Score = 87.8 bits (216), Expect = 2e-16
Identities = 61/212 (28%), Positives = 80/212 (37%), Gaps = 38/212 (17%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEP------ETGACQGC 1178
QC C PG G C C +G P C G S AC+P G CQ C
Sbjct: 554 QCECRPGVTGQRCDRCLSGAYDFPH-----------CQGSSSACDPAGTINSNLGYCQ-C 601
Query: 1179 QHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACS 1238
+ H EGP C +C+ Y+ + + P C C C+ D D H C
Sbjct: 602 KLHVEGPTCSRCKLLYW-NLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCH-----CK 655
Query: 1239 PGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDA-AGQCQCKA 1297
G C+ C GY+ S G GC CD G++SS C +G CQC+
Sbjct: 656 SHVGGDSCDTCEDGYFA--------LEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCRE 707
Query: 1298 QVEGLTCSHCRPHHF-----HLSASNPDGCLP 1324
V G C +++ H+ DG P
Sbjct: 708 HVVGKVCQRPENNYYFPDLHHMKYEIEDGSTP 739
Score = 83.2 bits (204), Expect = 5e-15
Identities = 53/172 (30%), Positives = 72/172 (41%), Gaps = 34/172 (19%)
Query: 1158 RCSCHGHSEAC---EPETGACQGCQHHTEGPRCEQCQPGY----YGDAQRGTPQDCQLCP 1210
+C C+GH+E C PE CQHHT G C++C GY + A +C+ C
Sbjct: 298 QCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACN 357
Query: 1211 CYGDPAAGQAAHTCFLDTD---------------GHPTCDACSPGHSGRHCERCAPGYYG 1255
C+G A C+ D D G C C +G +CE+CA GYY
Sbjct: 358 CHGH------ASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYY- 410
Query: 1256 NPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHC 1307
G P G I C+CDP+ + + +G+C CK G C C
Sbjct: 411 -RPYGVPVDAPD---GCIPCSCDPEHADGCE-QGSGRCHCKPNFHGDNCEKC 457
Score = 83.2 bits (204), Expect = 5e-15
Identities = 51/156 (32%), Positives = 65/156 (41%), Gaps = 33/156 (21%)
Query: 1530 CRCPPGYIGLSCQDCAPGYT----RTGSGLYLGHCELCECNGHSDLCHPET--------- 1576
C C G +C C GY R + CE C C+GH+ C+ +
Sbjct: 319 CECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASL 378
Query: 1577 ---------GACSQCQHNAAGEFCELCAPGYYG--DATAGTPEDCQPCACPLTNPENMFS 1625
G C CQHN AG CE CA GYY P+ C PC+C +PE+ +
Sbjct: 379 NTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSC---DPEH--A 433
Query: 1626 RTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNP 1661
CE G RC C+P + G CE+C GY P
Sbjct: 434 DGCEQ---GSGRC-HCKPNFHGDNCEKCAIGYYNFP 465
Score = 82.4 bits (202), Expect = 9e-15
Identities = 67/241 (27%), Positives = 91/241 (37%), Gaps = 54/241 (22%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGT----CSGCNCNGHASSC--DP--------- 775
C C G +C+ C + + P C CNC+GHAS+C DP
Sbjct: 319 CECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASL 378
Query: 776 ----VY---GHCLNCQHNTEGPQCNKCKAGF---FGDAMKATATSCRPCPCPYIDASRRF 825
+Y G C+NCQHNT G C +C G+ +G + A C PC C
Sbjct: 379 NTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDA-PDGCIPCSC-----DPEH 432
Query: 826 SDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEG---------NPIQPGGKCRPVNQEI 876
+D C G C C P + G CE CA GY P+ PV +I
Sbjct: 433 ADGC---EQGSGRCH-CKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDI 488
Query: 877 VRCD--ERGSMGTSGEA---CRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSR 931
CD G + +A C C+ V G C+ C G + C C+C +
Sbjct: 489 KGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPI-----CQACWCSALGS 543
Query: 932 H 932
+
Sbjct: 544 Y 544
Score = 65.1 bits (157), Expect = 1e-09
Identities = 50/176 (28%), Positives = 66/176 (37%), Gaps = 38/176 (21%)
Query: 764 CNCNGHASSC---DPVYGHCLNCQHNTEGPQCNKCKAGF----FGDAMKATATSCRPCPC 816
C CNGHA C +P CQH+T G C++C G+ + A + C C C
Sbjct: 299 CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358
Query: 817 PYIDASRRFSDTCFLDTD---------------GQATCDACAPGYTGRRCESCAPGY--- 858
+ C+ D D G C C G CE CA GY
Sbjct: 359 ------HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRP 412
Query: 859 EGNPIQPGGKCRPVNQEIVRCD--ERGSMGTSGEACRCKNNVVGRLCNECADGSFH 912
G P+ C P + + D E+GS C CK N G C +CA G ++
Sbjct: 413 YGVPVDAPDGCIPCSCDPEHADGCEQGS-----GRCHCKPNFHGDNCEKCAIGYYN 463
Score = 62.8 bits (151), Expect = 7e-09
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 19/127 (14%)
Query: 1563 CECNGHSDLCH---PETGACSQCQHNAAGEFCELCAPGY----YGDATAGTPEDCQPCAC 1615
C CNGH+++C+ PE +CQH+ GE C+ C GY + A +C+ C C
Sbjct: 299 CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358
Query: 1616 P------LTNPE---NMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGY---VGNPSV 1663
+P+ S + + AGG C C+ G CEQC GY G P
Sbjct: 359 HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVD 418
Query: 1664 QGGQCLP 1670
C+P
Sbjct: 419 APDGCIP 425
Score = 61.6 bits (148), Expect = 2e-08
Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 10/132 (7%)
Query: 4232 LEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDG 4291
++++T+++ GL+ G + F++L L G LVF + R+ S++ NDG
Sbjct: 3014 VDMQTTSSRGLVFHTGTK-------NSFMALYLSKGRLVFALGTDGKKLRIKSKEKCNDG 3066
Query: 4292 EWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSG 4351
+WH V +G +G + VDG G PG N ++ + VY+G P + ++
Sbjct: 3067 KWHTVVFGHDGEKGRLVVDGLRAREGSLPG-NSTISIRAPVYLGSPP--SGKPKSLPTNS 3123
Query: 4352 ITGCVKNLVLHS 4363
GC+KN L S
Sbjct: 3124 FVGCLKNFQLDS 3135
Score = 60.8 bits (146), Expect = 3e-08
Identities = 45/180 (25%), Positives = 70/180 (38%), Gaps = 25/180 (13%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPV------YGHCLNC 783
+C C G +G C+ C + P +C G +S+CDP G+C C
Sbjct: 554 QCECRPGVTGQRCDRCLSGAYDFP-----------HCQGSSSACDPAGTINSNLGYC-QC 601
Query: 784 QHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACA 843
+ + EGP C++CK + + K + C C C + G C C
Sbjct: 602 KLHVEGPTCSRCKL-LYWNLDKENPSGCSECKCHKAGTVSGTGEC----RQGDGDCH-CK 655
Query: 844 PGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLC 903
G C++C GY C+ +I G SG C+C+ +VVG++C
Sbjct: 656 SHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSG-VCQCREHVVGKVC 714
Score = 55.8 bits (133), Expect = 9e-07
Identities = 43/154 (27%), Positives = 58/154 (37%), Gaps = 33/154 (21%)
Query: 1530 CRCPPGYIGLSCQDCAPGY---------------TRTGSGLYLGHCELCECNGHS---DL 1571
C C P + G +C+ CA GY T + G + C+CN ++
Sbjct: 443 CHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEI 502
Query: 1572 CHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESL 1631
C G C C+ G C+ C G+Y CQ C C M C S+
Sbjct: 503 CDAH-GRCL-CRPGVEGPRCDTCRSGFYSFPI------CQACWCSALGSYQM---PCSSV 551
Query: 1632 GAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQG 1665
+C C PG TGQ C++C G P QG
Sbjct: 552 TG---QCE-CRPGVTGQRCDRCLSGAYDFPHCQG 581
Score = 53.1 bits (126), Expect = 6e-06
Identities = 26/69 (37%), Positives = 35/69 (50%), Gaps = 5/69 (7%)
Query: 1530 CRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL--CHPETGAC--SQCQHN 1585
C C GY G C+ CAPGY + G C+ C CN + L CHP TG C + + +
Sbjct: 1755 CSCKAGYTGTQCERCAPGYFGNPQK-FGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDS 1813
Query: 1586 AAGEFCELC 1594
+ E C+ C
Sbjct: 1814 SPAEECDDC 1822
Score = 50.4 bits (119), Expect = 4e-05
Identities = 24/69 (34%), Positives = 34/69 (49%), Gaps = 5/69 (7%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCN--GHASSCDPVYGHCLNCQHNTE 788
C C GY+G CE C + P + G+C C+CN G SC P+ G C+N +
Sbjct: 1755 CSCKAGYTGTQCERCAPGYFGNPQ-KFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDS 1813
Query: 789 GP--QCNKC 795
P +C+ C
Sbjct: 1814 SPAEECDDC 1822
Score = 47.0 bits (110), Expect = 4e-04
Identities = 21/65 (32%), Positives = 27/65 (41%), Gaps = 1/65 (1%)
Query: 1271 GPIGCNCDPQGSVSSQCD-AAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMG 1329
G + C C P G+ C GQC C+ V G C+ C H+ P C C
Sbjct: 1262 GALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEE 1321
Query: 1330 ITQQC 1334
+T QC
Sbjct: 1322 MTGQC 1326
Score = 46.2 bits (108), Expect = 7e-04
Identities = 42/165 (25%), Positives = 55/165 (33%), Gaps = 31/165 (18%)
Query: 1494 RATFSSVPLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGS 1553
R+ F S P+ + +L G P + +C C PG G C C S
Sbjct: 524 RSGFYSFPICQACWCSAL-----GSYQMPCSSVTGQCECRPGVTGQRCDRCL-------S 571
Query: 1554 GLYLGHCELCECNGHSDLCHP------ETGACSQCQHNAAGEFCELCAPGYYGDATAGTP 1607
G Y + C G S C P G C QC+ + G C C Y+ + P
Sbjct: 572 GAY----DFPHCQGSSSACDPAGTINSNLGYC-QCKLHVEGPTCSRCKLLYW-NLDKENP 625
Query: 1608 EDCQPCACPLTNPENMFSRTCESLG-------AGGYRCTACEPGY 1645
C C C + + G GG C CE GY
Sbjct: 626 SGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGY 670
Score = 43.9 bits (102), Expect = 0.004
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 5/74 (6%)
Query: 1529 ECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECN---GHSDLCHPETGACSQCQHN 1585
+C C G SC C GY Y G C+ C+C+ S +C +G C QC+ +
Sbjct: 651 DCHCKSHVGGDSCDTCEDGYFALEKSNYFG-CQGCQCDIGGALSSMCSGPSGVC-QCREH 708
Query: 1586 AAGEFCELCAPGYY 1599
G+ C+ YY
Sbjct: 709 VVGKVCQRPENNYY 722
Score = 43.1 bits (100), Expect = 0.006
Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 11/148 (7%)
Query: 3955 VEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWH 4014
V+ + + G++ +G K+ F++L + G L F ++S E G+WH
Sbjct: 3014 VDMQTTSSRGLVFHTGTKNS----FMALYLSKGRLVFALGTDGKKLRIKSKEKCNDGKWH 3069
Query: 4015 RVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFR 4074
V + G L V+G R S PG S +++ +YLG P S TN F
Sbjct: 3070 TVVFGHDGEKGRLVVDGLRAREGSLPGNST-ISIRAPVYLGSPPSGKPKSLPTN---SFV 3125
Query: 4075 GCVGEVSVNGKRLDLTYSFLGSQGIGQC 4102
GC+ ++ K L Y+ S G+ C
Sbjct: 3126 GCLKNFQLDSKPL---YTPSSSFGVSSC 3150
Score = 39.7 bits (91), Expect = 0.067
Identities = 45/163 (27%), Positives = 66/163 (40%), Gaps = 31/163 (19%)
Query: 4205 YFHDDGFLAFPGHVFSRSLPEVP-ETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLG 4263
YF G+ P + P P T ++T+ GLL + A G FISL
Sbjct: 2602 YFEGTGYARVP------TQPHAPIPTFGQTIQTTVDRGLLFF-------AENGDRFISLN 2648
Query: 4264 LQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEEL-------VS 4316
++DG L+ RY+L S L E + D A+ GR SIQ+ +L V
Sbjct: 2649 IEDGKLMVRYKLNS---ELPKERGVGD-------AINNGRDHSIQIKIGKLQKRMWINVD 2698
Query: 4317 GRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNL 4359
++ + V + Y+GG P + GC+KNL
Sbjct: 2699 VQNTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNL 2741
Score = 38.1 bits (87), Expect = 0.19
Identities = 18/66 (27%), Positives = 25/66 (37%), Gaps = 6/66 (9%)
Query: 868 KCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCM 927
+C P C G C C+ NV+GR C CA G + P C + C
Sbjct: 1267 ECHPTGATGPHCSPEGGQ------CPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCE 1320
Query: 928 GVSRHC 933
++ C
Sbjct: 1321 EMTGQC 1326
Score = 37.4 bits (85), Expect = 0.33
Identities = 19/74 (25%), Positives = 33/74 (44%), Gaps = 5/74 (6%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCN---GHASSCDPVYGHCLNCQHN 786
+C C G SC++C+ + + Y G C GC C+ +S C G C C+ +
Sbjct: 651 DCHCKSHVGGDSCDTCEDGYFALEKSNYFG-CQGCQCDIGGALSSMCSGPSGVC-QCREH 708
Query: 787 TEGPQCNKCKAGFF 800
G C + + ++
Sbjct: 709 VVGKVCQRPENNYY 722
Score = 35.8 bits (81), Expect = 0.96
Identities = 32/159 (20%), Positives = 62/159 (38%), Gaps = 19/159 (11%)
Query: 3687 EIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATI 3746
+ + + S+ G++ + G K F++ L GR F I
Sbjct: 3011 QFAVDMQTTSSRGLVFHTGTKN-------------SFMALYLSKGRLVFALGTDGKKLRI 3057
Query: 3747 RHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGA 3806
+ G +HTV +G L+V L G+ G + + +YLG P
Sbjct: 3058 KSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGN-STISIRAPVYLGSPP--SG 3114
Query: 3807 IPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHC 3845
PK+ ++ F+GC++ ++ + + ++ G+S C
Sbjct: 3115 KPKSLPTNSFVGCLKNFQLDSKPLYTPS---SSFGVSSC 3150
Score = 33.9 bits (76), Expect = 3.7
Identities = 27/89 (30%), Positives = 34/89 (38%), Gaps = 15/89 (16%)
Query: 3847 TCRDRPCQNGGQCHDSESSSYVCV-CPAGFTGSRCEHSQ------ALHCHPEACGPDAT- 3898
T R PC G + + S +CV C G CE Q A+H AC T
Sbjct: 1681 TGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTN 1740
Query: 3899 -----CVNRPDGRGYTCRCHLGRSGLRCE 3922
CV +G C C G +G +CE
Sbjct: 1741 SFATGCV--VNGGDVRCSCKAGYTGTQCE 1767
Score = 32.7 bits (73), Expect = 8.2
Identities = 40/158 (25%), Positives = 63/158 (39%), Gaps = 20/158 (12%)
Query: 3971 GKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGR-----WHRVSAERLNKDG 4025
G D++ +A+V G L Y LG A L+ + L RV +R+ +
Sbjct: 2440 GNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAVMDRVKFQRIYQFA 2499
Query: 4026 SLRVNGGRPVLR-SSPG--KSQGLNLHTLL---------YLGGVEPSVPLSPATNMSAHF 4073
L G + +PG G N +TLL Y+GG P L P+ +
Sbjct: 2500 RLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKL-PSRLSFPPY 2558
Query: 4074 RGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQ 4111
+GC+ +N L L Y+F + + + PC R+
Sbjct: 2559 KGCIELDDLNENVLSL-YNFKKTFNLNTT-EVEPCRRR 2594
>gi|189217425 laminin alpha 3 subunit isoform 3 [Homo sapiens]
Length = 3277
Score = 313 bits (803), Expect = 2e-84
Identities = 200/566 (35%), Positives = 260/566 (45%), Gaps = 63/566 (11%)
Query: 1115 TGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGA 1174
TG + E QC C P G C C TG+ P C+ CSC CE TG
Sbjct: 1274 TGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPR------CKPCSCG--RRLCEEMTGQ 1325
Query: 1175 CQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTC 1234
C+ C T P+CE C+ + C+ C C A C D+ C
Sbjct: 1326 CR-CPPRTVRPQCEVCETHSFSFHPMA---GCEGCNCSRRGTIEAAMPECDRDSG---QC 1378
Query: 1235 DACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCD-AAGQC 1293
C P +GR C+RCA G+Y + P + CNC+ G+ CD G C
Sbjct: 1379 -RCKPRITGRQCDRCASGFY-------------RFPECVPCNCNRDGTEPGVCDPGTGAC 1424
Query: 1294 QCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASSAYTR----HLISTHFA 1349
CK VEG C+ CR FHL +N GC CFC G+ QC SS R ++ H
Sbjct: 1425 LCKENVEGTECNVCREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLE 1484
Query: 1350 PGDFQGFAL-VNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKV 1408
D + NP NS + ++ +P S W P +Y GDKV
Sbjct: 1485 TADRVDIPVSFNPGSNSMVAD---LQELPATIH------------SASWVAPTSYLGDKV 1529
Query: 1409 AAYGGKLRYTLSYTAGPQGSPLSD--PDVQITGNNIMLVASQPALQGPERRSYEIMFREE 1466
++YGG L Y P L + PDVQ+TG ++ ++ + P+R + + E
Sbjct: 1530 SSYGGYLTYQAKSFGLPGDMVLLEKKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVE 1589
Query: 1467 --FWRRPDGQPATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNRPRA 1524
F P +RE L+ L+ L ++ I+ + + ++S V LE A S R A
Sbjct: 1590 GNFRHASSRAPVSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASDTGSGRI-A 1648
Query: 1525 LEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQH 1584
L VE C CPP Y G SCQ C+PGY R GLY G C C CNGHS+ C +G C CQH
Sbjct: 1649 LAVEICACPPAYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQH 1708
Query: 1585 NAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPG 1644
N AGE CE C GYYG+A G+ C+ C CP T N F+ C + G RC +C+ G
Sbjct: 1709 NTAGEHCERCQEGYYGNAVHGS---CRACPCPHT---NSFATGC-VVNGGDVRC-SCKAG 1760
Query: 1645 YTGQYCEQCGPGYVGNPSVQGGQCLP 1670
YTG CE+C PGY GNP GG C P
Sbjct: 1761 YTGTQCERCAPGYFGNPQKFGGSCQP 1786
Score = 271 bits (694), Expect = 8e-72
Identities = 184/569 (32%), Positives = 249/569 (43%), Gaps = 52/569 (9%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEG 789
+C C G C C P C C+C C+ + G C C T
Sbjct: 1284 QCPCQPNVIGRQCTRCATGHYGFP------RCKPCSCGRRL--CEEMTGQC-RCPPRTVR 1334
Query: 790 PQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGR 849
PQC C+ F A C C C C D+ GQ C P TGR
Sbjct: 1335 PQCEVCETHSFSFHPMA---GCEGCNCSRRGTIEAAMPECDRDS-GQCRCK---PRITGR 1387
Query: 850 RCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADG 909
+C+ CA G+ P C E CD GT AC CK NV G CN C +G
Sbjct: 1388 QCDRCASGFYRFPECVPCNCNRDGTEPGVCDP----GTG--ACLCKENVEGTECNVCREG 1441
Query: 910 SFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFSLTNAASTHTTNEGIF 969
SFHL N GC CFC GV+ C SS R + H + + F
Sbjct: 1442 SFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKF--VDMLGWHLETADRVDIPVS----F 1495
Query: 970 SPTPGELGFSSFHRLLSGPYF--WSLPSRFLGDKVTSYGGELRFTVTQRSQPGS-TPLHG 1026
+P + + L + + W P+ +LGDKV+SYGG L + PG L
Sbjct: 1496 NPGSNSM-VADLQELPATIHSASWVAPTSYLGDKVSSYGGYLTYQAKSFGLPGDMVLLEK 1554
Query: 1027 QPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFREQAWQRPDGQ-PATREHLLMALAGID 1085
+P V L G ++ + + P P + V E ++ + P +RE L+ L+ +
Sbjct: 1555 KPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAPVSREELMTVLSRLA 1614
Query: 1086 TLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYT 1145
+ I+ Y + +S + ++ A +G+ AL VE C+CPP Y G SCQ C GY
Sbjct: 1615 DVRIQGLYFTETQRLTLSEVGLEEASDTGSGR-IALAVEICACPPAYAGDSCQGCSPGYY 1673
Query: 1146 RTPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQD 1205
R GLY G C C+C+GHS C+ +G C CQH+T G CE+CQ GYYG+A G+
Sbjct: 1674 RDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGS--- 1730
Query: 1206 CQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQ-GQPCQ 1264
C+ CPC P A C ++ G C +C G++G CERCAPGY+GNP + G CQ
Sbjct: 1731 CRACPC---PHTNSFATGCVVN-GGDVRC-SCKAGYTGTQCERCAPGYFGNPQKFGGSCQ 1785
Query: 1265 RDSQVPGPIGCNCDPQGSVSSQCDAAGQC 1293
C+C+ G + S G C
Sbjct: 1786 ---------PCSCNSNGQLGSCHPLTGDC 1805
Score = 228 bits (581), Expect = 1e-58
Identities = 133/392 (33%), Positives = 203/392 (51%), Gaps = 41/392 (10%)
Query: 505 CPDGHFYLEHS--AACLPCFCFGITSVCQSTRR----FRDQIRLRFDQPDDFKGVNVTMP 558
C +G F+L+ + C CFCFG+ + C S+ + F D + + D V++ +
Sbjct: 1438 CREGSFHLDPANLKGCTSCFCFGVNNQCHSSHKRRTKFVDMLGWHLETADR---VDIPVS 1494
Query: 559 AQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNV 618
PG+ + + ++ + +H + W P +LG+KV SYGG L Y
Sbjct: 1495 FNPGSNSMVADLQELPAT--------------IHSASWVAPTSYLGDKVSSYGGYLTYQA 1540
Query: 619 R-YELARGMLEPVQRPDVVLMGAGYRLLSRGHTPTQPGALNQRQVQFSEEHWVHESGR-P 676
+ + L M+ ++PDV L G ++ +P L+ +V E ++ H S R P
Sbjct: 1541 KSFGLPGDMVLLEKKPDVQLTGQHMSIIYEETNTPRPDRLHHGRVHVVEGNFRHASSRAP 1600
Query: 677 VQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGR-AHSVEECRCPI 735
V R EL+ VL L V IQ +Y T+ + LS++ ++ T GR A +VE C CP
Sbjct: 1601 VSREELMTVLSRLADVRIQGLYFTETQRLTLSEVGLEEASD--TGSGRIALAVEICACPP 1658
Query: 736 GYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNKC 795
Y+G SC+ C + R G Y G C CNCNGH++ C G C+NCQHNT G C +C
Sbjct: 1659 AYAGDSCQGCSPGYYRDHKGLYTGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERC 1718
Query: 796 KAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCA 855
+ G++G+A+ SCR CPCP+ ++ F+ C ++ G C +C GYTG +CE CA
Sbjct: 1719 QEGYYGNAVHG---SCRACPCPHTNS---FATGCVVN-GGDVRC-SCKAGYTGTQCERCA 1770
Query: 856 PGYEGNPIQPGGKCRPVNQEIVRCDERGSMGT 887
PGY GNP + GG C+P + C+ G +G+
Sbjct: 1771 PGYFGNPQKFGGSCQPCS-----CNSNGQLGS 1797
Score = 113 bits (282), Expect = 5e-24
Identities = 75/238 (31%), Positives = 95/238 (39%), Gaps = 46/238 (19%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYT----RTPSGLYLGTCERCSCHGHSEAC--EPET------ 1172
+C C G +C C TGY R + CE C+CHGH+ C +P+
Sbjct: 318 RCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQAS 377
Query: 1173 ----------GACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQ--LCPCYGDPAAGQA 1220
G C CQH+T G CEQC GYY G P D PC DP +
Sbjct: 378 LNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYY--RPYGVPVDAPDGCIPCSCDP---EH 432
Query: 1221 AHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNP--------SQGQPCQRDSQVPGP 1272
A C G C C P G +CE+CA GYY P P D
Sbjct: 433 ADGC---EQGSGRCH-CKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDI 488
Query: 1273 IGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGI 1330
GC+C+ +G + CDA G+C C+ VEG C CR + C C+C +
Sbjct: 489 KGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPI-----CQACWCSAL 541
Score = 108 bits (269), Expect = 2e-22
Identities = 72/221 (32%), Positives = 95/221 (42%), Gaps = 47/221 (21%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSGLYL---------------GTCERCSCHGHS---E 1166
+C C P + G +C+ C GY P L + G + C C+ E
Sbjct: 442 RCHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPE 501
Query: 1167 ACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFL 1226
C+ G C C+ EGPRC+ C+ G+Y CQ C C A G C
Sbjct: 502 ICDAH-GRCL-CRPGVEGPRCDTCRSGFYSFPI------CQACWC---SALGSYQMPCSS 550
Query: 1227 DTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQ 1286
T C+ C PG +G+ C+RC G Y P CQ S CDP G+++S
Sbjct: 551 VTG---QCE-CRPGVTGQRCDRCLSGAYDFPH----CQGSSSA-------CDPAGTINSN 595
Query: 1287 CDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
G CQCK VEG TCS C+ +++L NP GC C C
Sbjct: 596 L---GYCQCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKC 633
Score = 90.5 bits (223), Expect = 3e-17
Identities = 62/214 (28%), Positives = 91/214 (42%), Gaps = 41/214 (19%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVP---------------GGPYLGTCSGCNCNGHA---SS 772
C C + G +CE C + P P G GC+CN
Sbjct: 443 CHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEI 502
Query: 773 CDPVYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLD 832
CD +G CL C+ EGP+C+ C++GF+ + C+ C C + + + C
Sbjct: 503 CD-AHGRCL-CRPGVEGPRCDTCRSGFYSFPI------CQACWCSALGS---YQMPCSSV 551
Query: 833 TDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEAC 892
T GQ C+ C PG TG+RC+ C G P G CD G++ ++ C
Sbjct: 552 T-GQ--CE-CRPGVTGQRCDRCLSGAYDFPHCQGSSSA--------CDPAGTINSNLGYC 599
Query: 893 RCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFC 926
+CK +V G C+ C ++L NP GC +C C
Sbjct: 600 QCKLHVEGPTCSRCKLLYWNLDKENPSGCSECKC 633
Score = 87.8 bits (216), Expect = 2e-16
Identities = 61/212 (28%), Positives = 80/212 (37%), Gaps = 38/212 (17%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCERCSCHGHSEACEP------ETGACQGC 1178
QC C PG G C C +G P C G S AC+P G CQ C
Sbjct: 554 QCECRPGVTGQRCDRCLSGAYDFPH-----------CQGSSSACDPAGTINSNLGYCQ-C 601
Query: 1179 QHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACS 1238
+ H EGP C +C+ Y+ + + P C C C+ D D H C
Sbjct: 602 KLHVEGPTCSRCKLLYW-NLDKENPSGCSECKCHKAGTVSGTGECRQGDGDCH-----CK 655
Query: 1239 PGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDA-AGQCQCKA 1297
G C+ C GY+ S G GC CD G++SS C +G CQC+
Sbjct: 656 SHVGGDSCDTCEDGYFA--------LEKSNYFGCQGCQCDIGGALSSMCSGPSGVCQCRE 707
Query: 1298 QVEGLTCSHCRPHHF-----HLSASNPDGCLP 1324
V G C +++ H+ DG P
Sbjct: 708 HVVGKVCQRPENNYYFPDLHHMKYEIEDGSTP 739
Score = 83.2 bits (204), Expect = 5e-15
Identities = 53/172 (30%), Positives = 72/172 (41%), Gaps = 34/172 (19%)
Query: 1158 RCSCHGHSEAC---EPETGACQGCQHHTEGPRCEQCQPGY----YGDAQRGTPQDCQLCP 1210
+C C+GH+E C PE CQHHT G C++C GY + A +C+ C
Sbjct: 298 QCVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACN 357
Query: 1211 CYGDPAAGQAAHTCFLDTD---------------GHPTCDACSPGHSGRHCERCAPGYYG 1255
C+G A C+ D D G C C +G +CE+CA GYY
Sbjct: 358 CHGH------ASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYY- 410
Query: 1256 NPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHC 1307
G P G I C+CDP+ + + +G+C CK G C C
Sbjct: 411 -RPYGVPVDAPD---GCIPCSCDPEHADGCE-QGSGRCHCKPNFHGDNCEKC 457
Score = 83.2 bits (204), Expect = 5e-15
Identities = 51/156 (32%), Positives = 65/156 (41%), Gaps = 33/156 (21%)
Query: 1530 CRCPPGYIGLSCQDCAPGYT----RTGSGLYLGHCELCECNGHSDLCHPET--------- 1576
C C G +C C GY R + CE C C+GH+ C+ +
Sbjct: 319 CECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASL 378
Query: 1577 ---------GACSQCQHNAAGEFCELCAPGYYG--DATAGTPEDCQPCACPLTNPENMFS 1625
G C CQHN AG CE CA GYY P+ C PC+C +PE+ +
Sbjct: 379 NTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDAPDGCIPCSC---DPEH--A 433
Query: 1626 RTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNP 1661
CE G RC C+P + G CE+C GY P
Sbjct: 434 DGCEQ---GSGRC-HCKPNFHGDNCEKCAIGYYNFP 465
Score = 82.4 bits (202), Expect = 9e-15
Identities = 67/241 (27%), Positives = 91/241 (37%), Gaps = 54/241 (22%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGT----CSGCNCNGHASSC--DP--------- 775
C C G +C+ C + + P C CNC+GHAS+C DP
Sbjct: 319 CECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNCHGHASNCYYDPDVERQQASL 378
Query: 776 ----VY---GHCLNCQHNTEGPQCNKCKAGF---FGDAMKATATSCRPCPCPYIDASRRF 825
+Y G C+NCQHNT G C +C G+ +G + A C PC C
Sbjct: 379 NTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVDA-PDGCIPCSC-----DPEH 432
Query: 826 SDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEG---------NPIQPGGKCRPVNQEI 876
+D C G C C P + G CE CA GY P+ PV +I
Sbjct: 433 ADGC---EQGSGRCH-CKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDI 488
Query: 877 VRCD--ERGSMGTSGEA---CRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSR 931
CD G + +A C C+ V G C+ C G + C C+C +
Sbjct: 489 KGCDCNLEGVLPEICDAHGRCLCRPGVEGPRCDTCRSGFYSFPI-----CQACWCSALGS 543
Query: 932 H 932
+
Sbjct: 544 Y 544
Score = 65.1 bits (157), Expect = 1e-09
Identities = 50/176 (28%), Positives = 66/176 (37%), Gaps = 38/176 (21%)
Query: 764 CNCNGHASSC---DPVYGHCLNCQHNTEGPQCNKCKAGF----FGDAMKATATSCRPCPC 816
C CNGHA C +P CQH+T G C++C G+ + A + C C C
Sbjct: 299 CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358
Query: 817 PYIDASRRFSDTCFLDTD---------------GQATCDACAPGYTGRRCESCAPGY--- 858
+ C+ D D G C C G CE CA GY
Sbjct: 359 ------HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRP 412
Query: 859 EGNPIQPGGKCRPVNQEIVRCD--ERGSMGTSGEACRCKNNVVGRLCNECADGSFH 912
G P+ C P + + D E+GS C CK N G C +CA G ++
Sbjct: 413 YGVPVDAPDGCIPCSCDPEHADGCEQGS-----GRCHCKPNFHGDNCEKCAIGYYN 463
Score = 62.8 bits (151), Expect = 7e-09
Identities = 39/127 (30%), Positives = 55/127 (43%), Gaps = 19/127 (14%)
Query: 1563 CECNGHSDLCH---PETGACSQCQHNAAGEFCELCAPGY----YGDATAGTPEDCQPCAC 1615
C CNGH+++C+ PE +CQH+ GE C+ C GY + A +C+ C C
Sbjct: 299 CVCNGHAEVCNINNPEKLFRCECQHHTCGETCDRCCTGYNQRRWRPAAWEQSHECEACNC 358
Query: 1616 P------LTNPE---NMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGY---VGNPSV 1663
+P+ S + + AGG C C+ G CEQC GY G P
Sbjct: 359 HGHASNCYYDPDVERQQASLNTQGIYAGGGVCINCQHNTAGVNCEQCAKGYYRPYGVPVD 418
Query: 1664 QGGQCLP 1670
C+P
Sbjct: 419 APDGCIP 425
Score = 61.6 bits (148), Expect = 2e-08
Identities = 38/132 (28%), Positives = 65/132 (49%), Gaps = 10/132 (7%)
Query: 4232 LEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDG 4291
++++T+++ GL+ G + F++L L G LVF + R+ S++ NDG
Sbjct: 2958 VDMQTTSSRGLVFHTGTK-------NSFMALYLSKGRLVFALGTDGKKLRIKSKEKCNDG 3010
Query: 4292 EWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSG 4351
+WH V +G +G + VDG G PG N ++ + VY+G P + ++
Sbjct: 3011 KWHTVVFGHDGEKGRLVVDGLRAREGSLPG-NSTISIRAPVYLGSPP--SGKPKSLPTNS 3067
Query: 4352 ITGCVKNLVLHS 4363
GC+KN L S
Sbjct: 3068 FVGCLKNFQLDS 3079
Score = 60.8 bits (146), Expect = 3e-08
Identities = 45/180 (25%), Positives = 70/180 (38%), Gaps = 25/180 (13%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPV------YGHCLNC 783
+C C G +G C+ C + P +C G +S+CDP G+C C
Sbjct: 554 QCECRPGVTGQRCDRCLSGAYDFP-----------HCQGSSSACDPAGTINSNLGYC-QC 601
Query: 784 QHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACA 843
+ + EGP C++CK + + K + C C C + G C C
Sbjct: 602 KLHVEGPTCSRCKL-LYWNLDKENPSGCSECKCHKAGTVSGTGEC----RQGDGDCH-CK 655
Query: 844 PGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLC 903
G C++C GY C+ +I G SG C+C+ +VVG++C
Sbjct: 656 SHVGGDSCDTCEDGYFALEKSNYFGCQGCQCDIGGALSSMCSGPSG-VCQCREHVVGKVC 714
Score = 55.8 bits (133), Expect = 9e-07
Identities = 43/154 (27%), Positives = 58/154 (37%), Gaps = 33/154 (21%)
Query: 1530 CRCPPGYIGLSCQDCAPGY---------------TRTGSGLYLGHCELCECNGHS---DL 1571
C C P + G +C+ CA GY T + G + C+CN ++
Sbjct: 443 CHCKPNFHGDNCEKCAIGYYNFPFCLRIPIFPVSTPSSEDPVAGDIKGCDCNLEGVLPEI 502
Query: 1572 CHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESL 1631
C G C C+ G C+ C G+Y CQ C C M C S+
Sbjct: 503 CDAH-GRCL-CRPGVEGPRCDTCRSGFYSFPI------CQACWCSALGSYQM---PCSSV 551
Query: 1632 GAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQG 1665
+C C PG TGQ C++C G P QG
Sbjct: 552 TG---QCE-CRPGVTGQRCDRCLSGAYDFPHCQG 581
Score = 53.1 bits (126), Expect = 6e-06
Identities = 26/69 (37%), Positives = 35/69 (50%), Gaps = 5/69 (7%)
Query: 1530 CRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL--CHPETGAC--SQCQHN 1585
C C GY G C+ CAPGY + G C+ C CN + L CHP TG C + + +
Sbjct: 1755 CSCKAGYTGTQCERCAPGYFGNPQK-FGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDS 1813
Query: 1586 AAGEFCELC 1594
+ E C+ C
Sbjct: 1814 SPAEECDDC 1822
Score = 50.4 bits (119), Expect = 4e-05
Identities = 24/69 (34%), Positives = 34/69 (49%), Gaps = 5/69 (7%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCN--GHASSCDPVYGHCLNCQHNTE 788
C C GY+G CE C + P + G+C C+CN G SC P+ G C+N +
Sbjct: 1755 CSCKAGYTGTQCERCAPGYFGNPQ-KFGGSCQPCSCNSNGQLGSCHPLTGDCINQEPKDS 1813
Query: 789 GP--QCNKC 795
P +C+ C
Sbjct: 1814 SPAEECDDC 1822
Score = 47.0 bits (110), Expect = 4e-04
Identities = 21/65 (32%), Positives = 27/65 (41%), Gaps = 1/65 (1%)
Query: 1271 GPIGCNCDPQGSVSSQCD-AAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMG 1329
G + C C P G+ C GQC C+ V G C+ C H+ P C C
Sbjct: 1262 GALPCECHPTGATGPHCSPEGGQCPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCEE 1321
Query: 1330 ITQQC 1334
+T QC
Sbjct: 1322 MTGQC 1326
Score = 46.2 bits (108), Expect = 7e-04
Identities = 42/165 (25%), Positives = 55/165 (33%), Gaps = 31/165 (18%)
Query: 1494 RATFSSVPLAASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGS 1553
R+ F S P+ + +L G P + +C C PG G C C S
Sbjct: 524 RSGFYSFPICQACWCSAL-----GSYQMPCSSVTGQCECRPGVTGQRCDRCL-------S 571
Query: 1554 GLYLGHCELCECNGHSDLCHP------ETGACSQCQHNAAGEFCELCAPGYYGDATAGTP 1607
G Y + C G S C P G C QC+ + G C C Y+ + P
Sbjct: 572 GAY----DFPHCQGSSSACDPAGTINSNLGYC-QCKLHVEGPTCSRCKLLYW-NLDKENP 625
Query: 1608 EDCQPCACPLTNPENMFSRTCESLG-------AGGYRCTACEPGY 1645
C C C + + G GG C CE GY
Sbjct: 626 SGCSECKCHKAGTVSGTGECRQGDGDCHCKSHVGGDSCDTCEDGY 670
Score = 43.9 bits (102), Expect = 0.004
Identities = 23/74 (31%), Positives = 33/74 (44%), Gaps = 5/74 (6%)
Query: 1529 ECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECN---GHSDLCHPETGACSQCQHN 1585
+C C G SC C GY Y G C+ C+C+ S +C +G C QC+ +
Sbjct: 651 DCHCKSHVGGDSCDTCEDGYFALEKSNYFG-CQGCQCDIGGALSSMCSGPSGVC-QCREH 708
Query: 1586 AAGEFCELCAPGYY 1599
G+ C+ YY
Sbjct: 709 VVGKVCQRPENNYY 722
Score = 43.1 bits (100), Expect = 0.006
Identities = 40/148 (27%), Positives = 64/148 (43%), Gaps = 11/148 (7%)
Query: 3955 VEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWH 4014
V+ + + G++ +G K+ F++L + G L F ++S E G+WH
Sbjct: 2958 VDMQTTSSRGLVFHTGTKNS----FMALYLSKGRLVFALGTDGKKLRIKSKEKCNDGKWH 3013
Query: 4015 RVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMSAHFR 4074
V + G L V+G R S PG S +++ +YLG P S TN F
Sbjct: 3014 TVVFGHDGEKGRLVVDGLRAREGSLPGNST-ISIRAPVYLGSPPSGKPKSLPTN---SFV 3069
Query: 4075 GCVGEVSVNGKRLDLTYSFLGSQGIGQC 4102
GC+ ++ K L Y+ S G+ C
Sbjct: 3070 GCLKNFQLDSKPL---YTPSSSFGVSSC 3094
Score = 39.7 bits (91), Expect = 0.067
Identities = 45/163 (27%), Positives = 66/163 (40%), Gaps = 31/163 (19%)
Query: 4205 YFHDDGFLAFPGHVFSRSLPEVP-ETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLG 4263
YF G+ P + P P T ++T+ GLL + A G FISL
Sbjct: 2546 YFEGTGYARVP------TQPHAPIPTFGQTIQTTVDRGLLFF-------AENGDRFISLN 2592
Query: 4264 LQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEEL-------VS 4316
++DG L+ RY+L S L E + D A+ GR SIQ+ +L V
Sbjct: 2593 IEDGKLMVRYKLNS---ELPKERGVGD-------AINNGRDHSIQIKIGKLQKRMWINVD 2642
Query: 4317 GRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNL 4359
++ + V + Y+GG P + GC+KNL
Sbjct: 2643 VQNTIIDGEVFDFSTYYLGGIPIAIRERFNISTPAFRGCMKNL 2685
Score = 38.1 bits (87), Expect = 0.19
Identities = 18/66 (27%), Positives = 25/66 (37%), Gaps = 6/66 (9%)
Query: 868 KCRPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCM 927
+C P C G C C+ NV+GR C CA G + P C + C
Sbjct: 1267 ECHPTGATGPHCSPEGGQ------CPCQPNVIGRQCTRCATGHYGFPRCKPCSCGRRLCE 1320
Query: 928 GVSRHC 933
++ C
Sbjct: 1321 EMTGQC 1326
Score = 37.4 bits (85), Expect = 0.33
Identities = 19/74 (25%), Positives = 33/74 (44%), Gaps = 5/74 (6%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCN---GHASSCDPVYGHCLNCQHN 786
+C C G SC++C+ + + Y G C GC C+ +S C G C C+ +
Sbjct: 651 DCHCKSHVGGDSCDTCEDGYFALEKSNYFG-CQGCQCDIGGALSSMCSGPSGVC-QCREH 708
Query: 787 TEGPQCNKCKAGFF 800
G C + + ++
Sbjct: 709 VVGKVCQRPENNYY 722
Score = 35.8 bits (81), Expect = 0.96
Identities = 32/159 (20%), Positives = 62/159 (38%), Gaps = 19/159 (11%)
Query: 3687 EIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISFGLVGGRPEFRFDAGSGMATI 3746
+ + + S+ G++ + G K F++ L GR F I
Sbjct: 2955 QFAVDMQTTSSRGLVFHTGTKN-------------SFMALYLSKGRLVFALGTDGKKLRI 3001
Query: 3747 RHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQGKFQGLDLNEELYLGGYPDYGA 3806
+ G +HTV +G L+V L G+ G + + +YLG P
Sbjct: 3002 KSKEKCNDGKWHTVVFGHDGEKGRLVVDGLRAREGSLPGN-STISIRAPVYLGSPP--SG 3058
Query: 3807 IPKAGLSSGFIGCVRELRIQGEEIVFHDLNLTAHGISHC 3845
PK+ ++ F+GC++ ++ + + ++ G+S C
Sbjct: 3059 KPKSLPTNSFVGCLKNFQLDSKPLYTPS---SSFGVSSC 3094
Score = 33.9 bits (76), Expect = 3.7
Identities = 27/89 (30%), Positives = 34/89 (38%), Gaps = 15/89 (16%)
Query: 3847 TCRDRPCQNGGQCHDSESSSYVCV-CPAGFTGSRCEHSQ------ALHCHPEACGPDAT- 3898
T R PC G + + S +CV C G CE Q A+H AC T
Sbjct: 1681 TGRCVPCNCNGHSNQCQDGSGICVNCQHNTAGEHCERCQEGYYGNAVHGSCRACPCPHTN 1740
Query: 3899 -----CVNRPDGRGYTCRCHLGRSGLRCE 3922
CV +G C C G +G +CE
Sbjct: 1741 SFATGCV--VNGGDVRCSCKAGYTGTQCE 1767
Score = 32.7 bits (73), Expect = 8.2
Identities = 40/158 (25%), Positives = 63/158 (39%), Gaps = 20/158 (12%)
Query: 3971 GKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGR-----WHRVSAERLNKDG 4025
G D++ +A+V G L Y LG A L+ + L RV +R+ +
Sbjct: 2384 GNKDASRDYIGMAVVDGQLTCVYNLGDREAELQVDQILTKSETKEAVMDRVKFQRIYQFA 2443
Query: 4026 SLRVNGGRPVLR-SSPG--KSQGLNLHTLL---------YLGGVEPSVPLSPATNMSAHF 4073
L G + +PG G N +TLL Y+GG P L P+ +
Sbjct: 2444 RLNYTKGATSSKPETPGVYDMDGRNSNTLLNLDPENVVFYVGGYPPDFKL-PSRLSFPPY 2502
Query: 4074 RGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQ 4111
+GC+ +N L L Y+F + + + PC R+
Sbjct: 2503 KGCIELDDLNENVLSL-YNFKKTFNLNTT-EVEPCRRR 2538
>gi|33469931 EGF-like, fibronectin type III and laminin G domains
isoform 2 [Homo sapiens]
Length = 775
Score = 296 bits (758), Expect = 3e-79
Identities = 203/715 (28%), Positives = 318/715 (44%), Gaps = 129/715 (18%)
Query: 3662 VVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQP 3721
V+ Y +S++ +K++Y+ F+I + FR ++ DG+LLY G+ + +
Sbjct: 151 VIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENE---------HGRG 201
Query: 3722 DFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNG 3781
DF+S ++ +FRF+ G+G+A I T + LG +HTV L R G L + + PV G
Sbjct: 202 DFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTG 261
Query: 3782 TSQGKFQGLDLNEELYLGGYPD-YGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNL--- 3837
SQG++ + LYLGG P Y + G + GF GCV+ L + G I L
Sbjct: 262 QSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKA 321
Query: 3838 -TAHGISHCPT--CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACG 3894
+ + C + C + C +GG C ++ SY+
Sbjct: 322 LSGADVGECSSGICDEASCIHGGTCTAIKADSYI-------------------------- 355
Query: 3895 PDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSL-SGAGSYLALPALTNTHHEL-- 3951
C C LG G CE+ T+T P SY A P H L
Sbjct: 356 ---------------CLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSF 400
Query: 3952 -RLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLAL 4010
++ F+P + DGVLL+S +DF+S+ + GGH+EFR++ GSG VLRS +PL L
Sbjct: 401 MEFEITFRPDSGDGVLLYSYDTGS--KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 458
Query: 4011 GRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMS 4070
G WH + R K+G L+V+ + V + G + +T +++GGV + + +
Sbjct: 459 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 518
Query: 4071 AHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCL 4130
F G + ++ +N + + + + F +
Sbjct: 519 KPFSGSIQKIILNDRTIHVKHDFTSGVNV------------------------------- 547
Query: 4131 CRDGFKGDLCEHEENPCQLREPCLHGGTC----QGTRCLCLPGFSGPRCQQGSGHGIAES 4186
E+ +PC +R PC HGG+C +G C C GF G CQ+ I
Sbjct: 548 ----------ENAAHPC-VRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAI--- 593
Query: 4187 DWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQ 4246
+ P G +L + + + + + +T+ GLLLW+
Sbjct: 594 ----------EIPQFIGR-----SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWR 638
Query: 4247 GVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGS 4306
G DFISLGL+DG LVF Y LGSG A ++ NDG WHRV A+R+G+ G
Sbjct: 639 GDS--PMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGK 696
Query: 4307 IQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361
I VD +G+SPG +N G++Y+GG ++A T ++ G+ GC+ + L
Sbjct: 697 ITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 751
Score = 216 bits (549), Expect = 5e-55
Identities = 149/514 (28%), Positives = 231/514 (44%), Gaps = 84/514 (16%)
Query: 3888 CHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNT 3947
C C D+ CVN G C+C LG+ G C E + + P G SY+ L N+
Sbjct: 113 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGH-SYVTFEPLKNS 171
Query: 3948 HHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEP 4007
+ ++ +EF+ A DG+LL+ G DF+SLA++ L+FR+ G+G+A++ S
Sbjct: 172 YQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETK 231
Query: 4008 LALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPAT 4067
+ LG WH V R +G L++N G PV S G+ + T LYLGG + L AT
Sbjct: 232 IKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRAT 291
Query: 4068 NMSAHFRGCVGEVSVNGKRLDLTYSFLG----SQGIGQCYDSSPCERQPCQHGATCMPAG 4123
+ F+GCV ++VNG+R+D+ LG +G+C S C+ C HG TC
Sbjct: 292 GTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC-SSGICDEASCIHGGTCTAIK 350
Query: 4124 EYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGI 4183
+ CLC GFKG CE L +P F + S
Sbjct: 351 ADSYICLCPLGFKGRHCE-------------------DAFTLTIPQF------RESLRSY 385
Query: 4184 AESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLL 4243
A + W LE P Y ++ E+ R + G+L
Sbjct: 386 AATPWPLE-------PQHYLSFME----------------------FEITFRPDSGDGVL 416
Query: 4244 LWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGR 4303
L+ + G KDF+S+ L GH+ FR+ GSG L SEDP+ G WH + R +
Sbjct: 417 LY-SYDTG----SKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAK 471
Query: 4304 RGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGI----TGCVKNL 4359
G +QVD +++V G + G + ++IGG P+ + + +SG+ +G ++ +
Sbjct: 472 NGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV---KKNSGVLKPFSGSIQKI 528
Query: 4360 VLHSARPGAPPPQPLDLQHRAQAGAN----TRPC 4389
+L+ + + ++H +G N PC
Sbjct: 529 ILND--------RTIHVKHDFTSGVNVENAAHPC 554
Score = 86.3 bits (212), Expect = 6e-16
Identities = 76/254 (29%), Positives = 109/254 (42%), Gaps = 40/254 (15%)
Query: 4143 EENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQY 4202
+E C C++ T G+RC C G G C + D QY
Sbjct: 114 DETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSE-------------------DIVIQY 154
Query: 4203 GAYFHDDGFLAFPGHVFSRSLPEVPE----TIELEVRTSTASGLLLWQGVEVGEAGQGKD 4258
+F GH + P I LE R GLLL+ G E G+G D
Sbjct: 155 PQFF---------GHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCG--ENEHGRG-D 202
Query: 4259 FISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGR 4318
F+SL + L FR+ G+G A +VSE I G WH V R+G G +Q++ V+G+
Sbjct: 203 FMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQ 262
Query: 4319 SPGPNVAVNAKGSVYIGGAPDVATLTGGRFSS-GITGCVKNLVLHSARPGAPPPQPLDLQ 4377
S G + + +Y+GGAP L ++ G GCV++L ++ R P PL
Sbjct: 263 SQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM-RPWPLG-- 319
Query: 4378 HRAQAGANTRPCPS 4391
+A +GA+ C S
Sbjct: 320 -KALSGADVGECSS 332
>gi|33469929 EGF-like, fibronectin type III and laminin G domains
isoform 1 [Homo sapiens]
Length = 1009
Score = 296 bits (758), Expect = 3e-79
Identities = 203/715 (28%), Positives = 318/715 (44%), Gaps = 129/715 (18%)
Query: 3662 VVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQP 3721
V+ Y +S++ +K++Y+ F+I + FR ++ DG+LLY G+ + +
Sbjct: 385 VIQYPQFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENE---------HGRG 435
Query: 3722 DFISFGLVGGRPEFRFDAGSGMATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNG 3781
DF+S ++ +FRF+ G+G+A I T + LG +HTV L R G L + + PV G
Sbjct: 436 DFMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTG 495
Query: 3782 TSQGKFQGLDLNEELYLGGYPD-YGAIPKAGLSSGFIGCVRELRIQGEEIVFHDLNL--- 3837
SQG++ + LYLGG P Y + G + GF GCV+ L + G I L
Sbjct: 496 QSQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDMRPWPLGKA 555
Query: 3838 -TAHGISHCPT--CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACG 3894
+ + C + C + C +GG C ++ SY+
Sbjct: 556 LSGADVGECSSGICDEASCIHGGTCTAIKADSYI-------------------------- 589
Query: 3895 PDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSL-SGAGSYLALPALTNTHHEL-- 3951
C C LG G CE+ T+T P SY A P H L
Sbjct: 590 ---------------CLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPWPLEPQHYLSF 634
Query: 3952 -RLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLAL 4010
++ F+P + DGVLL+S +DF+S+ + GGH+EFR++ GSG VLRS +PL L
Sbjct: 635 MEFEITFRPDSGDGVLLYSYDTGS--KDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTL 692
Query: 4011 GRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMS 4070
G WH + R K+G L+V+ + V + G + +T +++GGV + + +
Sbjct: 693 GNWHELRVSRTAKNGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDVKKNSGVL 752
Query: 4071 AHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCL 4130
F G + ++ +N + + + + F +
Sbjct: 753 KPFSGSIQKIILNDRTIHVKHDFTSGVNV------------------------------- 781
Query: 4131 CRDGFKGDLCEHEENPCQLREPCLHGGTC----QGTRCLCLPGFSGPRCQQGSGHGIAES 4186
E+ +PC +R PC HGG+C +G C C GF G CQ+ I
Sbjct: 782 ----------ENAAHPC-VRAPCAHGGSCRPRKEGYDCDCPLGFEGLHCQKAIIEAI--- 827
Query: 4187 DWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLLLWQ 4246
+ P G +L + + + + + +T+ GLLLW+
Sbjct: 828 ----------EIPQFIGR-----SYLTYDNPDILKRVSGSRSNVFMRFKTTAKDGLLLWR 872
Query: 4247 GVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGS 4306
G DFISLGL+DG LVF Y LGSG A ++ NDG WHRV A+R+G+ G
Sbjct: 873 GDS--PMRPNSDFISLGLRDGALVFSYNLGSGVASIMVNGSFNDGRWHRVKAVRDGQSGK 930
Query: 4307 IQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGITGCVKNLVL 4361
I VD +G+SPG +N G++Y+GG ++A T ++ G+ GC+ + L
Sbjct: 931 ITVDDYGARTGKSPGMMRQLNINGALYVGGMKEIALHTNRQYMRGLVGCISHFTL 985
Score = 216 bits (549), Expect = 5e-55
Identities = 149/514 (28%), Positives = 231/514 (44%), Gaps = 84/514 (16%)
Query: 3888 CHPEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTNT 3947
C C D+ CVN G C+C LG+ G C E + + P G SY+ L N+
Sbjct: 347 CDETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSEDIVIQYPQFFGH-SYVTFEPLKNS 405
Query: 3948 HHELRLDVEFKPLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEP 4007
+ ++ +EF+ A DG+LL+ G DF+SLA++ L+FR+ G+G+A++ S
Sbjct: 406 YQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLAIIRRSLQFRFNCGTGVAIIVSETK 465
Query: 4008 LALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPAT 4067
+ LG WH V R +G L++N G PV S G+ + T LYLGG + L AT
Sbjct: 466 IKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQSQGQYSKITFRTPLYLGGAPSAYWLVRAT 525
Query: 4068 NMSAHFRGCVGEVSVNGKRLDLTYSFLG----SQGIGQCYDSSPCERQPCQHGATCMPAG 4123
+ F+GCV ++VNG+R+D+ LG +G+C S C+ C HG TC
Sbjct: 526 GTNRGFQGCVQSLAVNGRRIDMRPWPLGKALSGADVGEC-SSGICDEASCIHGGTCTAIK 584
Query: 4124 EYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGI 4183
+ CLC GFKG CE L +P F + S
Sbjct: 585 ADSYICLCPLGFKGRHCE-------------------DAFTLTIPQF------RESLRSY 619
Query: 4184 AESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGLL 4243
A + W LE P Y ++ E+ R + G+L
Sbjct: 620 AATPWPLE-------PQHYLSFME----------------------FEITFRPDSGDGVL 650
Query: 4244 LWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGR 4303
L+ + G KDF+S+ L GH+ FR+ GSG L SEDP+ G WH + R +
Sbjct: 651 LY-SYDTG----SKDFLSINLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELRVSRTAK 705
Query: 4304 RGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGAPDVATLTGGRFSSGI----TGCVKNL 4359
G +QVD +++V G + G + ++IGG P+ + + +SG+ +G ++ +
Sbjct: 706 NGILQVDKQKIVEGMAEGGFTQIKCNTDIFIGGVPNYDDV---KKNSGVLKPFSGSIQKI 762
Query: 4360 VLHSARPGAPPPQPLDLQHRAQAGAN----TRPC 4389
+L+ + + ++H +G N PC
Sbjct: 763 ILND--------RTIHVKHDFTSGVNVENAAHPC 788
Score = 86.3 bits (212), Expect = 6e-16
Identities = 76/254 (29%), Positives = 109/254 (42%), Gaps = 40/254 (15%)
Query: 4143 EENPCQLREPCLHGGTCQGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQY 4202
+E C C++ T G+RC C G G C + D QY
Sbjct: 348 DETLCSADSFCVNDYTWGGSRCQCTLGKGGESCSE-------------------DIVIQY 388
Query: 4203 GAYFHDDGFLAFPGHVFSRSLPEVPE----TIELEVRTSTASGLLLWQGVEVGEAGQGKD 4258
+F GH + P I LE R GLLL+ G E G+G D
Sbjct: 389 PQFF---------GHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCG--ENEHGRG-D 436
Query: 4259 FISLGLQDGHLVFRYQLGSGEARLVSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGR 4318
F+SL + L FR+ G+G A +VSE I G WH V R+G G +Q++ V+G+
Sbjct: 437 FMSLAIIRRSLQFRFNCGTGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTGQ 496
Query: 4319 SPGPNVAVNAKGSVYIGGAPDVATLTGGRFSS-GITGCVKNLVLHSARPGAPPPQPLDLQ 4377
S G + + +Y+GGAP L ++ G GCV++L ++ R P PL
Sbjct: 497 SQGQYSKITFRTPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRIDM-RPWPLG-- 553
Query: 4378 HRAQAGANTRPCPS 4391
+A +GA+ C S
Sbjct: 554 -KALSGADVGECSS 566
>gi|110611156 laminin, gamma 3 precursor [Homo sapiens]
Length = 1575
Score = 284 bits (727), Expect = 1e-75
Identities = 217/684 (31%), Positives = 284/684 (41%), Gaps = 129/684 (18%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGT------CSGCNCNGHASSCD---------P 775
CRC +G CE C F P GT C CNC+G + C
Sbjct: 290 CRCQHNTTGTDCERCLPFFQDRPWAR--GTAEAAHECLPCNCSGRSEECTFDRELFRSTG 347
Query: 776 VYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDG 835
G C +C+ +T GP C +C+ F+ + C+PC C + + + L D
Sbjct: 348 HGGRCHHCRDHTAGPHCERCQENFYHWDPRMP---CQPCDC-------QSAGSLHLQCDD 397
Query: 836 QATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGT----SGEA 891
TC AC P TG +C+ C PG+ + GG CRP C+ GS+ T SG
Sbjct: 398 TGTC-ACKPTVTGWKCDRCLPGFHS--LSEGG-CRPCT-----CNPAGSLDTCDPRSGR- 447
Query: 892 CRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSR-----AQLHGA 946
C CK NV G LC+ C G+F+L NP GC CFC G S+ C S++ + + H
Sbjct: 448 CPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQG 507
Query: 947 SEEPGHFSLTNAASTHTTNEGIFSPTPGELGFSSFHRLLSGPYFWSLPSRFLGDKVTSYG 1006
+E G ++ + S H +SP L L + P +FLGD+ SYG
Sbjct: 508 AE--GWWARSVGGSEHPPQ---WSPNGVLLSPEDEEEL-------TAPEKFLGDQRFSYG 555
Query: 1007 GELRFTVTQRSQPGSTPLHGQPLVVLQGNNIILEHHVAQEP-SPGQPSTFIVPFREQAWQ 1065
L +T R PG +PL Q + G + L H P G P + F Q
Sbjct: 556 QPL--ILTFRVPPGDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETS 613
Query: 1066 RPDGQPATREHLLMALAGIDTLLIRASYAQQPA-ESRVSGISMDVAVPEETGQDPALEVE 1124
P H LA + +L +R S PA ++ + + A P + PA VE
Sbjct: 614 EDVAPPLPPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLS--PPASWVE 671
Query: 1125 QCSCPPGYRGPSCQDCDTGYTR-TPSGLYLGTCERCSCHGHSEACEPETGACQGCQHHTE 1183
CSCP GY G C+ C GY R P G +C C+C+ H C+P TG C C HHTE
Sbjct: 672 ICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCNQHG-TCDPNTGICV-CSHHTE 729
Query: 1184 GPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSG 1243
GP CE+C PG+YG+ G DCQ CPC GQ+A T + C C PG G
Sbjct: 730 GPSCERCLPGFYGNPFAGQADDCQPCPC-----PGQSACTT-IPESREVVCTHCPPGQRG 783
Query: 1244 RHCERCAPGYYGNP----SQGQPCQR---------------------------------- 1265
R CE C G++G+P QPC +
Sbjct: 784 RRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHC 843
Query: 1266 ---------DSQVPGP----IGCNCDPQGSVSSQ--CD-AAGQCQCKAQVEGLTCSHCRP 1309
+ P P + C+C PQGSVS Q CD GQC C V CS C P
Sbjct: 844 EHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTARDCSRCYP 903
Query: 1310 HHFHLSASNPDGCLPCFCMGITQQ 1333
F L GC C C + Q
Sbjct: 904 GFFDLQPGR--GCRSCKCHPLGSQ 925
Score = 262 bits (669), Expect = 6e-69
Identities = 215/690 (31%), Positives = 290/690 (42%), Gaps = 92/690 (13%)
Query: 1042 HVAQEPSPGQPSTFIVPFRE----QAWQRPDGQPATREHLLMALAGIDTL--------LI 1089
+VA G+PS + F E Q W T LL++L ++T +
Sbjct: 204 NVAFSTLEGRPSAY--NFEESPGLQEW-------VTSTELLISLDRLNTFGDDIFKDPKV 254
Query: 1090 RASYAQQPAESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTP- 1148
SY ++ V G E G D A ++ C C G C+ C + P
Sbjct: 255 LQSYYYAVSDFSVGGRCKCNGHASECGPDVAGQLA-CRCQHNTTGTDCERCLPFFQDRPW 313
Query: 1149 ---SGLYLGTCERCSCHGHSEACEPET---------GACQGCQHHTEGPRCEQCQPGYYG 1196
+ C C+C G SE C + G C C+ HT GP CE+CQ +Y
Sbjct: 314 ARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGGRCHHCRDHTAGPHCERCQENFYH 373
Query: 1197 DAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGN 1256
R CQ C C Q+A + L D TC AC P +G C+RC PG++
Sbjct: 374 WDPR---MPCQPCDC-------QSAGSLHLQCDDTGTC-ACKPTVTGWKCDRCLPGFHSL 422
Query: 1257 PSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSA 1316
G C+ C C+P GS+ + +G+C CK VEG C CRP F+L
Sbjct: 423 SEGG--CRP---------CTCNPAGSLDTCDPRSGRCPCKENVEGNLCDRCRPGTFNLQP 471
Query: 1317 SNPDGCLPCFCMGITQQCASSA-YTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEP 1375
NP GC CFC G ++ CAS+A + H I + F G +A S E +
Sbjct: 472 HNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWA------RSVGGSEHPPQW 525
Query: 1376 VPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDV 1435
P G LS + +L PE + GD+ +YG L L++ P SPL +
Sbjct: 526 SPNGVLLSPEDEEEL-------TAPEKFLGDQRFSYGQPL--ILTFRVPPGDSPL-PVQL 575
Query: 1436 QITGNNIMLVASQPALQGPE----RRSYEIMFREEFWRRPDGQPATREHLLMALADLDEL 1491
++ G + L +L GP+ R E+ F + P H LA+L L
Sbjct: 576 RLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPLPPFHFQRLLANLTSL 635
Query: 1492 LIRATFSSVPLA-ASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTR 1550
+R + P ++ V L A+PG S P A VE C CP GY G C+ CAPGY R
Sbjct: 636 RLRVSPGPSPAGPVFLTEVRLTSARPGLS--PPASWVEICSCPTGYTGQFCESCAPGYKR 693
Query: 1551 -TGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPED 1609
G C C CN H C P TG C C H+ G CE C PG+YG+ AG +D
Sbjct: 694 EMPQGGPYASCVPCTCNQHG-TCDPNTGIC-VCSHHTEGPSCERCLPGFYGNPFAGQADD 751
Query: 1610 CQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCL 1669
CQPC CP + + E + CT C PG G+ CE C G+ G+P G
Sbjct: 752 CQPCPCPGQSACTTIPESREVV------CTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQ 805
Query: 1670 P-ETNQAPLVVEVHPARSIVPQGGSHSLRC 1698
P Q V+ + + P G H LRC
Sbjct: 806 PCHQCQCSGNVDPNAVGNCDPLSG-HCLRC 834
Score = 164 bits (415), Expect = 2e-39
Identities = 134/444 (30%), Positives = 194/444 (43%), Gaps = 59/444 (13%)
Query: 505 CPDGHFYLE--HSAACLPCFCFGITSVCQSTRRFR-DQIRLRFDQ-PDDFKGVNVTMPAQ 560
C G F L+ + A C CFC+G + VC ST +F+ I F Q + + +V
Sbjct: 462 CRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEH 521
Query: 561 PGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRY 620
P P S + + P E +L+ PE+FLG++ SYG L R
Sbjct: 522 P--PQWSPNGVLLSPEDEE----ELTA-----------PEKFLGDQRFSYGQPLILTFRV 564
Query: 621 ELARGMLEPVQRPDVVLMGAGYRLLSRGHT---PTQPGALNQRQVQFSEEHWVHESGRPV 677
L PVQ + L G G L R + P G + +++F + + P+
Sbjct: 565 PPGDSPL-PVQ---LRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPL 620
Query: 678 QRAELLQVLQSLEAVLIQTVYNTKMAS-VGLSDIAMDTTVTHATSHGRAHSVEECRCPIG 736
++L +L ++ ++ A V L+++ + T A VE C CP G
Sbjct: 621 PPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRL--TSARPGLSPPASWVEICSCPTG 678
Query: 737 YSGLSCESCDAHFTR--VPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNK 794
Y+G CESC + R GGPY +C C CN H +CDP G C+ C H+TEGP C +
Sbjct: 679 YTGQFCESCAPGYKREMPQGGPY-ASCVPCTCNQH-GTCDPNTGICV-CSHHTEGPSCER 735
Query: 795 CKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESC 854
C GF+G+ A C+PCPCP A ++ + C C PG GRRCE C
Sbjct: 736 CLPGFYGNPFAGQADDCQPCPCPGQSACTTIPES------REVVCTHCPPGQRGRRCEVC 789
Query: 855 APGYEGNPIQPGGKCRPVNQ----------EIVRCDERGSMGTSGEACRCKNNVVGRLCN 904
G+ G+P+ G +P +Q + CD SG RC +N G C
Sbjct: 790 DDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDP-----LSGHCLRCLHNTTGDHCE 844
Query: 905 ECADGSF--HLSTRNPDGCLKCFC 926
C +G + L+ R D C+ C C
Sbjct: 845 HCQEGFYGSALAPRPADKCMPCSC 868
Score = 119 bits (298), Expect = 7e-26
Identities = 77/260 (29%), Positives = 104/260 (40%), Gaps = 64/260 (24%)
Query: 1122 EVEQCSCPPGYRGPSCQDCDTGYTRTPSGLY--LGTCERCSCHGHSEA-----CEPETGA 1174
EV CPPG RG C+ CD G+ P GL+ C +C C G+ + C+P +G
Sbjct: 771 EVVCTHCPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGH 830
Query: 1175 CQGCQHHTEGPRCEQCQPGYYGDAQRGTPQD-CQLCPCYG----------DPAAGQA--- 1220
C C H+T G CE CQ G+YG A P D C C C+ DP GQ
Sbjct: 831 CLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCL 890
Query: 1221 ----AHTC------FLDTDGHPTCDACS---------------------PGHSGRHCERC 1249
A C F D C +C PG +G+ C+RC
Sbjct: 891 PHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRC 950
Query: 1250 APGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRP 1309
G++G +G C+ C C P G+ S+QC G C C+ EG C C
Sbjct: 951 QLGFFGFSIKG--CR---------ACRCSPLGAASAQCHENGTCVCRPGFEGYKCDRCHD 999
Query: 1310 HHF-HLSASNPDGCLPCFCM 1328
+ F ++ C C+ +
Sbjct: 1000 NFFLTADGTHCQQCPSCYAL 1019
Score = 98.2 bits (243), Expect = 2e-19
Identities = 74/250 (29%), Positives = 96/250 (38%), Gaps = 71/250 (28%)
Query: 733 CPIGYSGLSCESCDAHFTRVPGGPY--LGTCSGCNCNGHAS-----SCDPVYGHCLNCQH 785
CP G G CE CD F P G + C C C+G+ +CDP+ GHCL C H
Sbjct: 777 CPPGQRGRRCEVCDDGFFGDPLGLFGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLH 836
Query: 786 NTEGPQCNKCKAGFFGDAMKAT-ATSCRPCPC----------------------PYI--- 819
NT G C C+ GF+G A+ A C PC C P++
Sbjct: 837 NTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCLPHVTAR 896
Query: 820 DASRRF-----------------------SDTCFLDTDGQATCDACAPGYTGRRCESCAP 856
D SR + D C T GQ TC PG TG+ C+ C
Sbjct: 897 DCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKT-GQCTC---RPGVTGQACDRCQL 952
Query: 857 GYEGNPIQPGGKCR--PVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADGSFHLS 914
G+ G I+ CR P+ +C E G+ C C+ G C+ C D F
Sbjct: 953 GFFGFSIKGCRACRCSPLGAASAQCHENGT-------CVCRPGFEGYKCDRCHDNFF--L 1003
Query: 915 TRNPDGCLKC 924
T + C +C
Sbjct: 1004 TADGTHCQQC 1013
Score = 92.4 bits (228), Expect = 9e-18
Identities = 59/175 (33%), Positives = 80/175 (45%), Gaps = 28/175 (16%)
Query: 1522 PRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGH---CELCECNGHSDL-----CH 1573
P + EV CPPG G C+ C G+ GL+ GH C C+C+G+ D C
Sbjct: 767 PESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGLF-GHPQPCHQCQCSGNVDPNAVGNCD 825
Query: 1574 PETGACSQCQHNAAGEFCELCAPGYYGDATAGTPED-CQPCACPLTNPENMFSRTCESLG 1632
P +G C +C HN G+ CE C G+YG A A P D C PC+C +P+ S
Sbjct: 826 PLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSC---HPQGSVSEQMPCDP 882
Query: 1633 AGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQG-------------GQCLPETNQ 1674
G +C +C P T + C +C PG+ +G QC P+T Q
Sbjct: 883 VTG-QC-SCLPHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQ 935
Score = 70.1 bits (170), Expect = 5e-11
Identities = 39/130 (30%), Positives = 57/130 (43%), Gaps = 23/130 (17%)
Query: 1529 ECRCPPGYIGLSCQDCAPGY--TRTGSGLYLGHCELCECN---GHSDLCHPETGACSQCQ 1583
+C C P C C PG+ + G G C C+C+ D CHP+TG C+ C+
Sbjct: 886 QCSCLPHVTARDCSRCYPGFFDLQPGRG-----CRSCKCHPLGSQEDQCHPKTGQCT-CR 939
Query: 1584 HNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEP 1643
G+ C+ C G++G + G C+ C C +P S C G C P
Sbjct: 940 PGVTGQACDRCQLGFFGFSIKG----CRACRC---SPLGAASAQCHENGT-----CVCRP 987
Query: 1644 GYTGQYCEQC 1653
G+ G C++C
Sbjct: 988 GFEGYKCDRC 997
Score = 57.8 bits (138), Expect = 2e-07
Identities = 38/128 (29%), Positives = 53/128 (41%), Gaps = 19/128 (14%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASS---CDPVYGHCLNCQHN 786
+C C + C C F + G C C C+ S C P G C C+
Sbjct: 886 QCSCLPHVTARDCSRCYPGFFDLQPGR---GCRSCKCHPLGSQEDQCHPKTGQC-TCRPG 941
Query: 787 TEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGY 846
G C++C+ GFFG ++K CR C C + A+ S C TC C PG+
Sbjct: 942 VTGQACDRCQLGFFGFSIK----GCRACRCSPLGAA---SAQC----HENGTC-VCRPGF 989
Query: 847 TGRRCESC 854
G +C+ C
Sbjct: 990 EGYKCDRC 997
Score = 47.8 bits (112), Expect = 2e-04
Identities = 29/91 (31%), Positives = 43/91 (47%), Gaps = 10/91 (10%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCN--GHASSCDPVYGHCLNCQHNT 787
+C C G +G +C+ C F G + C C C+ G AS+ G C+ C+
Sbjct: 935 QCTCRPGVTGQACDRCQLGFF----GFSIKGCRACRCSPLGAASAQCHENGTCV-CRPGF 989
Query: 788 EGPQCNKCKAGFFGDAMKATATSCRPCPCPY 818
EG +C++C FF + A T C+ CP Y
Sbjct: 990 EGYKCDRCHDNFF---LTADGTHCQQCPSCY 1017
Score = 43.1 bits (100), Expect = 0.006
Identities = 31/102 (30%), Positives = 37/102 (36%), Gaps = 26/102 (25%)
Query: 3845 CPTCRDRPC-QNGGQCHDSESSSYVCVCPAGFTGSRCEHSQ------------ALHCHP- 3890
C +C+ P QCH C C G TG C+ Q A C P
Sbjct: 914 CRSCKCHPLGSQEDQCHPKTGQ---CTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPL 970
Query: 3891 ----EACGPDATCVNRPDGRGYTC-RCH----LGRSGLRCEE 3923
C + TCV RP GY C RCH L G C++
Sbjct: 971 GAASAQCHENGTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQ 1012
Score = 33.5 bits (75), Expect = 4.8
Identities = 23/82 (28%), Positives = 32/82 (39%), Gaps = 8/82 (9%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCE------HSQAL-HCHPEACGPDATCV 3900
C+ CQ+ G H + C C TG +C+ HS + C P C P A +
Sbjct: 380 CQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNP-AGSL 438
Query: 3901 NRPDGRGYTCRCHLGRSGLRCE 3922
+ D R C C G C+
Sbjct: 439 DTCDPRSGRCPCKENVEGNLCD 460
>gi|145309326 laminin, gamma 1 precursor [Homo sapiens]
Length = 1609
Score = 269 bits (688), Expect = 4e-71
Identities = 186/561 (33%), Positives = 263/561 (46%), Gaps = 65/561 (11%)
Query: 1126 CSCPPGYRGPSCQDCDTGYTRTP----SGLYLGTCERCSCHGHSEAC--EPET------- 1172
C+C G C+ C + P + C C C+G S+ C +PE
Sbjct: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
Query: 1173 GACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHP 1232
G C CQ +T+G CE+C+ ++ + G + C C C G + C D +
Sbjct: 365 GHCTNCQDNTDGAHCERCRENFF---RLGNNEACSSCHC---SPVGSLSTQC----DSYG 414
Query: 1233 TCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQ 1292
C +C PG G C+RC PG++ G C+ C+CDP GS+ G+
Sbjct: 415 RC-SCKPGVMGDKCDRCQPGFHSLTEAG--CRP---------CSCDPSGSIDECNIETGR 462
Query: 1293 CQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFCMGITQQCASS-AYTRHLISTHFAPG 1351
C CK VEG C C+P F+L +SNP GC PCFC G + C ++ Y+ + IS+ F
Sbjct: 463 CVCKDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQI- 521
Query: 1352 DFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGNFAQLGHESFYWQLPETYQGDKVAAY 1411
D G+ + S + E++ E + A +S F + Y+ P + G +V +Y
Sbjct: 522 DEDGWR-AEQRDGSEASLEWSSER-QDIAVISDSYFPR------YFIAPAKFLGKQVLSY 573
Query: 1412 GGKLRYTLSYTAGPQGSPLSDPDVQITGNNIMLVASQPAL-QG---PERRSYEIMFR-EE 1466
G L + S+ + + LS D+ + G + + S P + QG P + + +FR E
Sbjct: 574 GQNLSF--SFRVDRRDTRLSAEDLVLEGAGLRV--SVPLIAQGNSYPSETTVKYVFRLHE 629
Query: 1467 FWRRPDGQPATREHLLMALADLDELLIRATFSSVPLAASISAVSLEVAQPGPSNRPRALE 1526
P T L +L + IR T+S A + V+L A+PGP A
Sbjct: 630 ATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSE-RSAGYLDDVTLASARPGPG--VPATW 686
Query: 1527 VEECRCPPGYIGLSCQDCAPGYTRTGSGL-YLGHCELCECNGHSDLCHPETGACSQCQHN 1585
VE C CP GY G C+ C GY R L C LC CNGHS+ C PETG C+ C+ N
Sbjct: 687 VESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVCN-CRDN 745
Query: 1586 AAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGY 1645
AG CE C+ GYYGD+TAGT DCQPC CP + + +T E + CT C G
Sbjct: 746 TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVV------CTNCPTGT 799
Query: 1646 TGQYCEQCGPGYVGNPSVQGG 1666
TG+ CE C GY G+P + G
Sbjct: 800 TGKRCELCDDGYFGDPLGRNG 820
Score = 267 bits (682), Expect = 2e-70
Identities = 201/680 (29%), Positives = 281/680 (41%), Gaps = 130/680 (19%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPG----GPYLGTCSGCNCNGHASSC--DPVY------- 777
C C G+ CE C F P C C+CNG + C DP
Sbjct: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
Query: 778 GHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQA 837
GHC NCQ NT+G C +C+ FF +C C C + + S C D
Sbjct: 365 GHCTNCQDNTDGAHCERCRENFF---RLGNNEACSSCHCSPVGS---LSTQC----DSYG 414
Query: 838 TCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSG---EACRC 894
C +C PG G +C+ C PG+ + G CRP + CD GS+ C C
Sbjct: 415 RC-SCKPGVMGDKCDRCQPGFHS--LTEAG-CRPCS-----CDPSGSIDECNIETGRCVC 465
Query: 895 KNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSRHCTSSSWSRAQLHGASEEPGHFS 954
K+NV G C C G F+L + NP GC CFC G S CT++ +S
Sbjct: 466 KDNVEGFNCERCKPGFFNLESSNPRGCTPCFCFGHSSVCTNAV--------------GYS 511
Query: 955 LTNAASTHTTNEGIF-----SPTPGELGFSSFHR---LLSGPYF---WSLPSRFLGDKVT 1003
+ + +ST +E + + L +SS + ++S YF + P++FLG +V
Sbjct: 512 VYSISSTFQIDEDGWRAEQRDGSEASLEWSSERQDIAVISDSYFPRYFIAPAKFLGKQVL 571
Query: 1004 SYGGELRFTVTQRSQPGSTPLHGQPLVVLQGNNIILEHHVAQEPSPGQPSTFIVPFR-EQ 1062
SYG L F+ R T L + LV+ + +AQ S +T FR +
Sbjct: 572 SYGQNLSFSF--RVDRRDTRLSAEDLVLEGAGLRVSVPLIAQGNSYPSETTVKYVFRLHE 629
Query: 1063 AWQRPDGQPATREHLLMALAGIDTLLIRASYAQQPAESRVSGISMDVAVPEETGQDPALE 1122
A P T L + ++ IR +Y+++ A + +++ A P PA
Sbjct: 630 ATDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSA-GYLDDVTLASARPGP--GVPATW 686
Query: 1123 VEQCSCPPGYRGPSCQDCDTGYTR-TPSGLYLGTCERCSCHGHSEACEPETGACQGCQHH 1181
VE C+CP GY G C+ C +GY R TP+ C C+C+GHSE C+PETG C C+ +
Sbjct: 687 VESCTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVC-NCRDN 745
Query: 1182 TEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPA----------------AGQAAHTCF 1225
T GP CE+C GYYGD+ GT DCQ CPC G + G C
Sbjct: 746 TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCE 805
Query: 1226 LDTDGH-----------------------------------PTCDACSPGHSGRHCERCA 1250
L DG+ C C +G +C+RC
Sbjct: 806 LCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGECLKCIYNTAGFYCDRCK 865
Query: 1251 PGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCD---AAGQCQCKAQVEGLTCSHC 1307
G++GNP P + CNC+ G++ Q GQC+C V G C C
Sbjct: 866 DGFFGNPLAPNPADKCK------ACNCNLYGTMKQQSSCNPVTGQCECLPHVTGQDCGAC 919
Query: 1308 RPHHFHLSASNPDGCLPCFC 1327
P ++L + GC C C
Sbjct: 920 DPGFYNLQSG--QGCERCDC 937
Score = 177 bits (448), Expect = 3e-43
Identities = 134/449 (29%), Positives = 197/449 (43%), Gaps = 66/449 (14%)
Query: 505 CPDGHFYLEHS--AACLPCFCFGITSVCQSTRRFR----------DQIRLRFDQPDDFKG 552
C G F LE S C PCFCFG +SVC + + D+ R +Q D
Sbjct: 477 CKPGFFNLESSNPRGCTPCFCFGHSSVCTNAVGYSVYSISSTFQIDEDGWRAEQRDG--- 533
Query: 553 VNVTMPAQPGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGG 612
S L+ + ++ S ++ P +FLG +V SYG
Sbjct: 534 --------------SEASLEWSSERQDIAVISDS----YFPRYFIAPAKFLGKQVLSYGQ 575
Query: 613 SLRYNVRYELARGMLEPVQRPDVVLMGAGYR----LLSRGHTPTQPGALNQRQVQFSEEH 668
+L ++ R + L D+VL GAG R L+++G++ P + V E
Sbjct: 576 NLSFSFRVDRRDTRLSA---EDLVLEGAGLRVSVPLIAQGNS--YPSETTVKYVFRLHEA 630
Query: 669 WVHESGRPVQRAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHATSHGRAHSV 728
+ + E ++L +L ++ I+ Y+ + A L D+ + + A V
Sbjct: 631 TDYPWRPALTPFEFQKLLNNLTSIKIRGTYSERSAGY-LDDVTLASA--RPGPGVPATWV 687
Query: 729 EECRCPIGYSGLSCESCDAHFTR-VPG-GPYLGTCSGCNCNGHASSCDPVYGHCLNCQHN 786
E C CP+GY G CE C + + R P GPY C C CNGH+ +CDP G C NC+ N
Sbjct: 688 ESCTCPVGYGGQFCEMCLSGYRRETPNLGPY-SPCVLCACNGHSETCDPETGVC-NCRDN 745
Query: 787 TEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGY 846
T GP C KC G++GD+ T++ C+PCPCP S + + C C G
Sbjct: 746 TAGPHCEKCSDGYYGDSTAGTSSDCQPCPCP------GGSSCAVVPKTKEVVCTNCPTGT 799
Query: 847 TGRRCESCAPGYEGNPIQPGGKCRPVNQEIVRCDER---GSMGT----SGEACRCKNNVV 899
TG+RCE C GY G+P+ G R + +C + ++G +GE +C N
Sbjct: 800 TGKRCELCDDGYFGDPLGRNGPVRLC--RLCQCSDNIDPNAVGNCNRLTGECLKCIYNTA 857
Query: 900 GRLCNECADGSF--HLSTRNPDGCLKCFC 926
G C+ C DG F L+ D C C C
Sbjct: 858 GFYCDRCKDGFFGNPLAPNPADKCKACNC 886
Score = 117 bits (292), Expect = 3e-25
Identities = 73/225 (32%), Positives = 100/225 (44%), Gaps = 47/225 (20%)
Query: 1122 EVEQCSCPPGYRGPSCQDCDTGYTRTPSGLY--LGTCERCSCHGHSEA-----CEPETGA 1174
EV +CP G G C+ CD GY P G + C C C + + C TG
Sbjct: 789 EVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNRLTGE 848
Query: 1175 CQGCQHHTEGPRCEQCQPGYYGDAQRGTPQD-CQLCPC--YG--------DPAAGQAAHT 1223
C C ++T G C++C+ G++G+ P D C+ C C YG +P GQ
Sbjct: 849 CLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQ---- 904
Query: 1224 CFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSV 1283
C+ C P +G+ C C PG+Y N GQ C+R C+C GS
Sbjct: 905 ----------CE-CLPHVTGQDCGACDPGFY-NLQSGQGCER---------CDCHALGST 943
Query: 1284 SSQCDA-AGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
+ QCD GQC+C+ + G C C +HF P+GC PC C
Sbjct: 944 NGQCDIRTGQCECQPGITGQHCERCEVNHFGFG---PEGCKPCDC 985
Score = 88.6 bits (218), Expect = 1e-16
Identities = 64/199 (32%), Positives = 91/199 (45%), Gaps = 31/199 (15%)
Query: 1522 PRALEVEECRCPPGYIGLSCQDCAPGY--TRTGSGLYLGHCELCECNGHSDL-----CHP 1574
P+ EV CP G G C+ C GY G + C LC+C+ + D C+
Sbjct: 785 PKTKEVVCTNCPTGTTGKRCELCDDGYFGDPLGRNGPVRLCRLCQCSDNIDPNAVGNCNR 844
Query: 1575 ETGACSQCQHNAAGEFCELCAPGYYGDATAGTPED-CQPCACPL------TNPENMFSRT 1627
TG C +C +N AG +C+ C G++G+ A P D C+ C C L + N +
Sbjct: 845 LTGECLKCIYNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQ 904
Query: 1628 CESL-GAGGYRCTACEPGY----TGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVH 1682
CE L G C AC+PG+ +GQ CE+C +G+ + GQC T Q E
Sbjct: 905 CECLPHVTGQDCGACDPGFYNLQSGQGCERCDCHALGSTN---GQCDIRTGQC----ECQ 957
Query: 1683 PARSIVPQGGSHSLRCQVS 1701
P + G H RC+V+
Sbjct: 958 PGIT-----GQHCERCEVN 971
Score = 85.9 bits (211), Expect = 8e-16
Identities = 67/247 (27%), Positives = 98/247 (39%), Gaps = 65/247 (26%)
Query: 733 CPIGYSGLSCESCDAHFTRVP---GGPYLGTCSGCNCNGH-----ASSCDPVYGHCLNCQ 784
CP G +G CE CD + P GP + C C C+ + +C+ + G CL C
Sbjct: 795 CPTGTTGKRCELCDDGYFGDPLGRNGP-VRLCRLCQCSDNIDPNAVGNCNRLTGECLKCI 853
Query: 785 HNTEGPQCNKCKAGFFGDAMKAT-ATSCRPCPCPYIDASRRFSDT--------CFLDTDG 835
+NT G C++CK GFFG+ + A C+ C C ++ S C G
Sbjct: 854 YNTAGFYCDRCKDGFFGNPLAPNPADKCKACNCNLYGTMKQQSSCNPVTGQCECLPHVTG 913
Query: 836 QATCDACAPGY----TGRRCE---------------------SCAPGYEGNPIQ------ 864
Q C AC PG+ +G+ CE C PG G +
Sbjct: 914 Q-DCGACDPGFYNLQSGQGCERCDCHALGSTNGQCDIRTGQCECQPGITGQHCERCEVNH 972
Query: 865 ----PGGKCRPVNQEIVRCDERGSMGTSGE---ACRCKNNVVGRLCNECADGSFHLSTRN 917
P G C+P + C GS+ + C C+ VG C++C + F+ R+
Sbjct: 973 FGFGPEG-CKPCD-----CHPEGSLSLQCKDDGRCECREGFVGNRCDQCEENYFY--NRS 1024
Query: 918 PDGCLKC 924
GC +C
Sbjct: 1025 WPGCQEC 1031
Score = 80.9 bits (198), Expect = 3e-14
Identities = 50/145 (34%), Positives = 63/145 (43%), Gaps = 19/145 (13%)
Query: 1529 ECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDL---CHPETGACSQCQHN 1585
+C C P G C C PG+ SG CE C+C+ C TG C +CQ
Sbjct: 904 QCECLPHVTGQDCGACDPGFYNLQSGQ---GCERCDCHALGSTNGQCDIRTGQC-ECQPG 959
Query: 1586 AAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGY 1645
G+ CE C ++G PE C+PC C +PE S C+ G RC C G+
Sbjct: 960 ITGQHCERCEVNHFGFG----PEGCKPCDC---HPEGSLSLQCKDDG----RC-ECREGF 1007
Query: 1646 TGQYCEQCGPGYVGNPSVQGGQCLP 1670
G C+QC Y N S G Q P
Sbjct: 1008 VGNRCDQCEENYFYNRSWPGCQECP 1032
Score = 65.9 bits (159), Expect = 9e-10
Identities = 49/196 (25%), Positives = 65/196 (33%), Gaps = 61/196 (31%)
Query: 1530 CRCPPGYIGLSCQDCAPGYT----RTGSGLYLGHCELCECNGHSDLCH--PET------- 1576
C C G+ C+ C P + R + C C+CNG S C+ PE
Sbjct: 305 CNCKHNTYGVDCEKCLPFFNDRPWRRATAESASECLPCDCNGRSQECYFDPELYRSTGHG 364
Query: 1577 GACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLG---- 1632
G C+ CQ N G CE C ++ G E C C C +P S C+S G
Sbjct: 365 GHCTNCQDNTDGAHCERCRENFF---RLGNNEACSSCHC---SPVGSLSTQCDSYGRCSC 418
Query: 1633 ---AGGYRCTACEPGY-----------------------------------TGQYCEQCG 1654
G +C C+PG+ G CE+C
Sbjct: 419 KPGVMGDKCDRCQPGFHSLTEAGCRPCSCDPSGSIDECNIETGRCVCKDNVEGFNCERCK 478
Query: 1655 PGYVGNPSVQGGQCLP 1670
PG+ S C P
Sbjct: 479 PGFFNLESSNPRGCTP 494
Score = 64.3 bits (155), Expect = 3e-09
Identities = 45/153 (29%), Positives = 64/153 (41%), Gaps = 21/153 (13%)
Query: 730 ECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASS---CDPVYGHCLNCQHN 786
+C C +G C +CD F + G C C+C+ S+ CD G C CQ
Sbjct: 904 QCECLPHVTGQDCGACDPGFYNLQSGQ---GCERCDCHALGSTNGQCDIRTGQC-ECQPG 959
Query: 787 TEGPQCNKCKAGFFGDAMKATATSCRPCPC-PYIDASRRFSDTCFLDTDGQATCDACAPG 845
G C +C+ FG + C+PC C P S + D DG+ C+ C G
Sbjct: 960 ITGQHCERCEVNHFGFGPEG----CKPCDCHPEGSLSLQCKD------DGR--CE-CREG 1006
Query: 846 YTGRRCESCAPGYEGNPIQPGGKCRPVNQEIVR 878
+ G RC+ C Y N PG + P +V+
Sbjct: 1007 FVGNRCDQCEENYFYNRSWPGCQECPACYRLVK 1039
Score = 60.8 bits (146), Expect = 3e-08
Identities = 38/119 (31%), Positives = 53/119 (44%), Gaps = 13/119 (10%)
Query: 1563 CECNGHSDLC--HPETGACSQCQHNAAGEFCELCAPGYYGD-----ATAGTPEDCQPCAC 1615
C+CNGH+ C + C+HN G CE C P ++ D ATA + +C PC C
Sbjct: 286 CKCNGHASECMKNEFDKLVCNCKHNTYGVDCEKCLP-FFNDRPWRRATAESASECLPCDC 344
Query: 1616 PLTNPENMFS-RTCESLGAGGYRCTACEPGYTGQYCEQCGPGYV---GNPSVQGGQCLP 1670
+ E F S G GG+ CT C+ G +CE+C + N + C P
Sbjct: 345 NGRSQECYFDPELYRSTGHGGH-CTNCQDNTDGAHCERCRENFFRLGNNEACSSCHCSP 402
Score = 52.8 bits (125), Expect = 8e-06
Identities = 32/102 (31%), Positives = 43/102 (42%), Gaps = 14/102 (13%)
Query: 717 THATSHGRAHSVEECRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNC--NGHASSCD 774
T S+GR C C G G C+ C F + C C+C +G C+
Sbjct: 408 TQCDSYGR------CSCKPGVMGDKCDRCQPGFHSLTE----AGCRPCSCDPSGSIDECN 457
Query: 775 PVYGHCLNCQHNTEGPQCNKCKAGFFGDAMKATATSCRPCPC 816
G C+ C+ N EG C +CK GFF + + C PC C
Sbjct: 458 IETGRCV-CKDNVEGFNCERCKPGFF-NLESSNPRGCTPCFC 497
Score = 51.2 bits (121), Expect = 2e-05
Identities = 33/93 (35%), Positives = 44/93 (47%), Gaps = 15/93 (16%)
Query: 1125 QCSCPPGYRGPSCQDCDTGYTRT-PSGLYLGTCERCSCHGH---SEACEPETGACQGCQH 1180
QC C PG G C+ C+ + P G C+ C CH S C+ + G C+ C+
Sbjct: 953 QCECQPGITGQHCERCEVNHFGFGPEG-----CKPCDCHPEGSLSLQCKDD-GRCE-CRE 1005
Query: 1181 HTEGPRCEQCQPGYYGDAQRGTPQDCQLCP-CY 1212
G RC+QC+ Y+ R P CQ CP CY
Sbjct: 1006 GFVGNRCDQCEENYF--YNRSWP-GCQECPACY 1035
Score = 42.7 bits (99), Expect = 0.008
Identities = 24/99 (24%), Positives = 41/99 (41%), Gaps = 7/99 (7%)
Query: 1517 GPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECN--GHSDLCHP 1574
G +N + +C C PG G C+ C + G C+ C+C+ G L
Sbjct: 941 GSTNGQCDIRTGQCECQPGITGQHCERCEVNHFGFGP----EGCKPCDCHPEGSLSLQCK 996
Query: 1575 ETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPC 1613
+ G C +C+ G C+ C Y+ + + ++C C
Sbjct: 997 DDGRC-ECREGFVGNRCDQCEENYFYNRSWPGCQECPAC 1034
Score = 36.2 bits (82), Expect = 0.74
Identities = 24/76 (31%), Positives = 32/76 (42%), Gaps = 15/76 (19%)
Query: 3857 GQCHDSESSSYVCVCPAGFTGSRCEHSQALH-------CHPEACGPDA--TCVNRPDGRG 3907
GQC + + C C G TG CE + H C P C P+ + + DGR
Sbjct: 945 GQC---DIRTGQCECQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGR- 1000
Query: 3908 YTCRCHLGRSGLRCEE 3923
C C G G RC++
Sbjct: 1001 --CECREGFVGNRCDQ 1014
Score = 35.4 bits (80), Expect = 1.3
Identities = 82/370 (22%), Positives = 116/370 (31%), Gaps = 84/370 (22%)
Query: 3869 CVCPAGFTGSRCE---------------HSQALHC----HPEACGPDA-TCVNRPDGRGY 3908
C CP G+ G CE +S + C H E C P+ C R + G
Sbjct: 690 CTCPVGYGGQFCEMCLSGYRRETPNLGPYSPCVLCACNGHSETCDPETGVCNCRDNTAGP 749
Query: 3909 TC-RCHLGRSGLRCEEGVTVTTPSLSGAGSYLALPALTN----THHELRLDVEFKPLAPD 3963
C +C G G + P GS A+ T T+ + L D
Sbjct: 750 HCEKCSDGYYGDSTAGTSSDCQPCPCPGGSSCAVVPKTKEVVCTNCPTGTTGKRCELCDD 809
Query: 3964 GVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRSAEPLALGRWHRVSAERLN- 4022
G G++GPV L +++ P A+G +R++ E L
Sbjct: 810 GYFGDPLGRNGPVR-LCRLCQCSDNID----------------PNAVGNCNRLTGECLKC 852
Query: 4023 ------------KDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVPLSPATNMS 4070
KDG G P+ + K + N + LY G ++ +P T
Sbjct: 853 IYNTAGFYCDRCKDGFF----GNPLAPNPADKCKACNCN--LY-GTMKQQSSCNPVTGQC 905
Query: 4071 AHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCL 4130
G+ G Y+ QG +C C +G + G QC
Sbjct: 906 ECLPHVTGQDC--GACDPGFYNLQSGQGCERC----DCHALGSTNGQCDIRTG----QCE 955
Query: 4131 CRDGFKGDLCEHEE-----------NPCQLREPCLHGGTCQGT-RCLCLPGFSGPRCQQG 4178
C+ G G CE E PC C+ RC C GF G RC Q
Sbjct: 956 CQPGITGQHCERCEVNHFGFGPEGCKPCDCHPEGSLSLQCKDDGRCECREGFVGNRCDQC 1015
Query: 4179 SGHGIAESDW 4188
+ W
Sbjct: 1016 EENYFYNRSW 1025
>gi|239755187 PREDICTED: similar to hemicentin 2 [Homo sapiens]
Length = 1215
Score = 267 bits (682), Expect = 2e-70
Identities = 226/709 (31%), Positives = 306/709 (43%), Gaps = 86/709 (12%)
Query: 2982 SPADSGEYVCRAASGPGPEQ-EASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDAS 3040
S A+ G Y C A S G + +A VT PP + + P+ TV G+ A
Sbjct: 370 SKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQ-----------LVPAPNVTVSPGETAV 418
Query: 3041 FKCLIHDGAAPISLEWKTRNQELEDNV-HISPNGSI-ITIVGTRPSNHGTYRCVASNAYG 3098
C + G AP +L W + L + ++ + + I G P++ G Y+CVASNA G
Sbjct: 419 LSCRVL-GEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANG 477
Query: 3099 VAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ 3158
V ++ V L V P VS+ + + G V + C ++G P W+R S L++
Sbjct: 478 VTRASVWLLVREAPQVSIHTSSQHFSQ-GVEVKVSCSASGYPTPHISWSRESQA---LQE 533
Query: 3159 RTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE 3218
+ +D+ L I P DAG Y C A N +GT Q+ V + P V A
Sbjct: 534 DSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTD------PPSVSAVN 587
Query: 3219 AELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDT---LIIPRVAQQDSGQ 3275
A + V G A L C A+G P P + W R L EG + L IP ++D+G
Sbjct: 588 AVVLVAVGEEAVLVCEASGVPPPRVIW--YRGGLEMILAPEGSSSGKLRIPAAQERDAGT 645
Query: 3276 YICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRV 3335
Y C A + G A A I L V P T +P +V+ G + L C A G PP T W R
Sbjct: 646 YTCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRR- 704
Query: 3336 GSSLP-------GRATARNE----LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQG 3384
G P GR + + +L FE APED Y C N G +A A+L+V G
Sbjct: 705 GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG 764
Query: 3385 --PPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLR-WFKEGGQLP 3441
PP A S PTV+V G V C V + R R W K+G LP
Sbjct: 765 HAPPQI-------ASSAPTVRVLE-------GQPVSLPCIVLAGRPLPERHWLKDGRPLP 810
Query: 3442 PG--HSVQ-DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQ 3498
PG HS++ DG L + Q G Y C A G +LV+Q P I+ +
Sbjct: 811 PGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPR--IHPTATHH 868
Query: 3499 TVVVGHAVEFECLALGDPKPQVTWSKV-------GGHLRPGIVQSGGVVRIAHVELADAG 3551
G C+A G P P +TW+K G H V G + IA DAG
Sbjct: 869 ITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYN---VSKEGTLLIAQPSAQDAG 925
Query: 3552 QYRCTATNAAGTTQSHVLLLVQALPQISM--------PQEVRVPAGSAAVFPCIASGYPT 3603
Y CTATN G + + L V P+I M P +V AG C A G P
Sbjct: 926 AYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLDCEAKGSPP 985
Query: 3604 PDISWSKLDGSLPPDSR----LENNMLMLPSVRPQDAGTYVCTATNRQG 3648
P ++W+K +PP + L + L L V+ D+G Y CTA+N G
Sbjct: 986 PLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAG 1034
Score = 258 bits (660), Expect = 7e-68
Identities = 219/760 (28%), Positives = 318/760 (41%), Gaps = 94/760 (12%)
Query: 2882 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2941
+ S A+ G Y C +GT A + + P +PAP + V+ G+T
Sbjct: 368 RASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVT-----------VSPGET 416
Query: 2942 LDLNCVVPGQAHAQVTWYKRGGSLPARH----QTHGSQLRLHLVSPADSGEYVCRAASGP 2997
L+C V G+A +TW + LPA Q L + + P D G Y C A++
Sbjct: 417 AVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNAN 476
Query: 2998 GPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWK 3057
G + + + + +P +SI S QG + C P + W
Sbjct: 477 GVTRASVWLLV----------REAPQVSIHTSSQHFSQGVEVKVSCSASGYPTP-HISWS 525
Query: 3058 TRNQELEDN--VHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVS 3115
+Q L+++ +H+ G++I I G P + G Y C A+N G Q V L PP+VS
Sbjct: 526 RESQALQEDSRIHVDAQGTLI-IQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSVS 584
Query: 3116 VLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSA 3175
+ V V VG+ L C ++G P W R LE S L+I +A
Sbjct: 585 AV-NAVVLVAVGEEAVLVCEASGVPPPRVIWYR-----GGLEMILAPEGSSSGKLRIPAA 638
Query: 3176 KPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSA 3235
+ DAGTY C A N LG A ++++ V APQ+ ++TVE G +A L C A
Sbjct: 639 QERDAGTYTCRAVNELGDASAEIQLAVGH------APQLTELPRDVTVELGRSALLACRA 692
Query: 3236 TGSPAPTIHWSKLRSPLPWQHRL-----------EGDTLIIPRVAQQDSGQYICNATSPA 3284
TG P PT+ W + P RL + L VA +D Y+C A +
Sbjct: 693 TGRPPPTVTWRR-GDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
Query: 3285 G--HAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQ-WSRVGSSLP- 3340
G AEA +I+ +PP + V G+ V L C+ PL + W + G LP
Sbjct: 752 GKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPP 811
Query: 3341 -GRATARNE-LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGS 3398
R + R + LH +RA E +GRY C TN GS +L+VQ PP P
Sbjct: 812 GSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHP-------- 863
Query: 3399 TPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP---PGHSV-QDGVLRIQ 3454
T T +T + G C + W KE L P ++V ++G L I
Sbjct: 864 TATHHITNE------GVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIA 917
Query: 3455 NLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQ-----TVVVGHAVEFE 3509
G Y+C A G + +L + P + +N + T G V +
Sbjct: 918 QPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMNGSRNANVPLQVTAKAGEEVTLD 977
Query: 3510 CLALGDPKPQVTWSKVGGHLRP-----GIVQSGGVVRIAHVELADAGQYRCTATNAAGTT 3564
C A G P P VTW+K + P G++ SG + R+A V++ D+G Y CTA+N AG+
Sbjct: 978 CEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSL-RLAQVQVGDSGHYECTASNPAGSA 1036
Query: 3565 QSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTP 3604
+L VQ PQ + VP P SG P
Sbjct: 1037 SHRYVLGVQGRTS-WQPQSLPVPH-----HPACLSGLSVP 1070
Score = 243 bits (620), Expect = 3e-63
Identities = 199/679 (29%), Positives = 281/679 (41%), Gaps = 57/679 (8%)
Query: 2998 GPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWK 3057
G + E + + V S +P++S+ P Q C +H A P L+ +
Sbjct: 287 GKDHEGNPLLRVSGVSYSGVAPGAPLVSMAPRIHGYLH-QPLLVSCSVHS-ALPFRLQLR 344
Query: 3058 TRNQELEDNVHISPNG-SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV 3116
L + H +G S I+ + GTY C A + G ++ + V PP +
Sbjct: 345 RGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPP-QL 403
Query: 3117 LPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK 3176
+P V V G+ L C GE + W R R L D L+IS
Sbjct: 404 VPAPNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLS--LEISGII 461
Query: 3177 PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT 3236
P+D G Y C+A NA G + V ++V APQV + G + CSA+
Sbjct: 462 PTDGGRYQCVASNANGVTRASVWLLVRE------APQVSIHTSSQHFSQGVEVKVSCSAS 515
Query: 3237 GSPAPTIHWSKLRSPLPWQHRLEGD---TLIIPRVAQQDSGQYICNATSPAGHAEATIIL 3293
G P P I WS+ L R+ D TLII VA +D+G Y C AT+ G + T+ L
Sbjct: 516 GYPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTL 575
Query: 3294 HVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL----PGRATARNEL 3349
+ PP + V V GE L C A G PP W R G + G ++ +
Sbjct: 576 YYTDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGK--- 632
Query: 3350 LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE 3409
L A D+G Y CR N++G A A QL V G P + P+
Sbjct: 633 LRIPAAQERDAGTYTCRAVNELGDASAEIQLAV--------------GHAPQLTELPRDV 678
Query: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG-----------HSVQDGVLRIQNLDQ 3458
T +G S C + W + GQ P G GVL +++
Sbjct: 679 TVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGAGRGSRSRQPDSGVLFFESVAP 737
Query: 3459 SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLAL-GDPK 3517
Q Y+C+A +GK QA A+L++ I V+ G V C+ L G P
Sbjct: 738 EDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPL 797
Query: 3518 PQVTWSKVGGHLRPG---IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQA 3574
P+ W K G L PG +++ G + + AG+Y C ATN AG+ V L+VQ
Sbjct: 798 PERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQV 857
Query: 3575 LPQISMPQEVRVP-AGSAAVFPCIASGYPTPDISWSKLDGSL----PPDSRLENNMLMLP 3629
P+I + G A PC+ASG P P I+W+K +L P + + L++
Sbjct: 858 PPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIA 917
Query: 3630 SVRPQDAGTYVCTATNRQG 3648
QDAG YVCTATN G
Sbjct: 918 QPSAQDAGAYVCTATNTVG 936
Score = 212 bits (540), Expect = 6e-54
Identities = 206/742 (27%), Positives = 292/742 (39%), Gaps = 91/742 (12%)
Query: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGS 1693
G Y CTA TG+ Q V +P Q +P N V V P + V
Sbjct: 375 GTYECTAVSRAGTGRAKAQI---VVTDPPPQ---LVPAPN-----VTVSPGETAV----- 418
Query: 1694 HSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSEL--HFPSVQPSDAGVYICTCRNL 1751
L C+V G P+ W R D R +P+ T + Q ++L + P+D G Y C N
Sbjct: 419 --LSCRVLGEAPYNLTWVR-DWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNA 475
Query: 1752 HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
+ + LLV EAP I + SQ G +V C+A S P + W+R
Sbjct: 476 NGVTRASVWLLVREAPQVSIHTS-----SQHFSQGVEVKVSCSA-SGYPTPHISWSRESQ 529
Query: 1812 GKLPTRAM--DFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVS 1869
+ D G L I+ V DAG Y C +N DQ T TL+ P VS
Sbjct: 530 ALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYY-----TDPPSVS 584
Query: 1870 IHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQA 1929
+ V G+ A C A+G P P + W G + A G LR+PA + D
Sbjct: 585 AVNAVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSGKLRIPAAQERDAG 644
Query: 1930 QYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITW 1989
Y CRA + G A L V G P++ P V GR+ L CRA G P T+TW
Sbjct: 645 TYTCRAVNELGDASAEIQLAV--GHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTW 702
Query: 1990 RKEGG-------SLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVV 2042
R+ G +RS + D L ++ D Y+C A + G QA +++V
Sbjct: 703 RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIV 762
Query: 2043 LSASDASPPPVKIESSSPSVTEGQTLDLNCVV-AGSAHAQVTWYRRGGSLPP---HTQVH 2098
+ +PP + + + V EGQ + L C+V AG + W + G LPP H+
Sbjct: 763 ---TGHAPPQIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRA 819
Query: 2099 GSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEP 2158
L L + +G Y C N +G + + + V P RI P
Sbjct: 820 DGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVV----------------QVPPRIHP 863
Query: 2159 SSSH--VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH-----QTHGSLLRLHQVTPA 2211
+++H EG L CV G +TW K +L +R G+LL + Q +
Sbjct: 864 TATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLL-IAQPSAQ 922
Query: 2212 DSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSS-------TVAEGQTLDL 2264
D+G YVC T G + +++ P + + S + T G+ + L
Sbjct: 923 DAGAYVCTATNTVGFSSQEMRLSVNTK------PRIHMNGSRNANVPLQVTAKAGEEVTL 976
Query: 2265 SCVVAGQAHAQVTWYKRGGSLPARHQVRG----SRLYIFQASPADAGQYVCRASNGMEAS 2320
C G VTW K +P G L + Q D+G Y C ASN ++
Sbjct: 977 DCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSA 1036
Query: 2321 ITVTVTGTQGANLAYPAGSTQP 2342
V G QG P P
Sbjct: 1037 SHRYVLGVQGRTSWQPQSLPVP 1058
Score = 209 bits (531), Expect = 6e-53
Identities = 210/747 (28%), Positives = 302/747 (40%), Gaps = 101/747 (13%)
Query: 1822 NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQ 1881
N I ++ GTY CT + + A + V P + P +TV PG+
Sbjct: 361 NSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVT-----DPPPQLVPAPNVTVSPGE 415
Query: 1882 LAEFRCSATGSPTPTLEWTGGPGGQLPAK----AQIHGGILRLPAVEPTDQAQYLCRAHS 1937
A C G L W LPA AQ+ L + + PTD +Y C A +
Sbjct: 416 TAVLSCRVLGEAPYNLTWVRD-WRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASN 474
Query: 1938 SAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLP 1997
+ G V RA + + P+V + G V++ C A+G P+ I+W +E +L
Sbjct: 475 ANG--VTRASVWLLVREAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQALQ 532
Query: 1998 PQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIES 2057
+R TL+I + DAG Y C AT+ GT Q + V L +D PP V +
Sbjct: 533 EDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQ---ETVTLYYTD--PPSVSAVN 587
Query: 2058 SSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGS--LPPHTQVHGSRLRLPQVSPADSGEY 2115
+ V G+ L C +G +V WYR G L P G +LR+P D+G Y
Sbjct: 588 AVVLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPEGSSSG-KLRIPAAQERDAGTY 646
Query: 2116 VCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVV 2175
CR N G A I ++V H P T +P R + +E G++ L C
Sbjct: 647 TCRAVNELGDASAEIQLAVGH----APQLTELP---RDVTVE-------LGRSALLACRA 692
Query: 2176 PGQAHAQVTWHKRGGSLP-----------ARHQTHGSLLRLHQVTPADSGEYVCHVVGTS 2224
G+ VTW +RG P Q +L V P D YVC
Sbjct: 693 TGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVF 751
Query: 2225 GPLEASVLVTIEASVIPGPIPPVRIESSSST--VAEGQTLDLSCVV-AGQAHAQVTWYKR 2281
G ++A + ++ G PP +I SS+ T V EGQ + L C+V AG+ + W K
Sbjct: 752 GKVQAEARL-----IVTGHAPP-QIASSAPTVRVLEGQPVSLPCIVLAGRPLPERHWLKD 805
Query: 2282 GGSLP--ARHQVRG-SRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAG 2338
G LP +RH +R L++ +A AG+Y C A+N G+Q ++
Sbjct: 806 GRPLPPGSRHSIRADGSLHLDRALQEHAGRYSCVATN---------TAGSQHRDVELVV- 855
Query: 2339 STQPIRIEPSSSQ--VAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRH-----QTHGSL 2391
P RI P+++ EG L CV G +TW K +L R G+L
Sbjct: 856 -QVPPRIHPTATHHITNEGVPASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTL 914
Query: 2392 LRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAE- 2450
L + Q S D+G YVC T+ + L V RI + S+ A
Sbjct: 915 L-IAQPSAQDAGAYVCTATN-----------TVGFSSQEMRLSVNTKPRIHMNGSRNANV 962
Query: 2451 --------GQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHG----SRLRLLQVTPADS 2498
G+ + L+C G VTW K +P +G LRL QV DS
Sbjct: 963 PLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPSGSLRLAQVQVGDS 1022
Query: 2499 GEYVCRVVGSSGTQEASVLVTIQQRLS 2525
G Y C +G+ ++ +Q R S
Sbjct: 1023 GHYECTASNPAGSASHRYVLGVQGRTS 1049
Score = 194 bits (493), Expect = 2e-48
Identities = 214/801 (26%), Positives = 313/801 (39%), Gaps = 97/801 (12%)
Query: 1649 YCEQCGPGYVGNP--SVQGGQCLPETNQAPLVVEVHPARSIVPQ--GGSHS---LRCQVS 1701
Y + G + GNP V G APLV S+ P+ G H + C V
Sbjct: 282 YLKVKGKDHEGNPLLRVSGVSYSGVAPGAPLV-------SMAPRIHGYLHQPLLVSCSVH 334
Query: 1702 GSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAEL 1761
+ P R + R Q S ++ G Y CT + + ++A++
Sbjct: 335 SALPFRLQLRRGEARLGEERHFQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQI 394
Query: 1762 LVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTR------LHNGKLP 1815
+VT+ P + + + +V PG C ++P Y L W R G++
Sbjct: 395 VVTDPPPQLVPAP-----NVTVSPGETAVLSCRVLGEAP-YNLTWVRDWRVLPASTGRVA 448
Query: 1816 TRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQL 1875
A D + L I + +D G Y C SN + + + L V+ AP VSIH
Sbjct: 449 QLA-DLS--LEISGIIPTDGGRYQCVASNANGVTRASVWLLVR-----EAPQVSIHTSSQ 500
Query: 1876 TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH---GGILRLPAVEPTDQAQYL 1932
G + CSA+G PTP + W+ L ++IH G L + V P D Y
Sbjct: 501 HFSQGVEVKVSCSASGYPTPHISWS-RESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYS 559
Query: 1933 CRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKE 1992
C+A + G L+ P V V G L C A+GVP + W +
Sbjct: 560 CQATNEVGTDQETVTLYY--TDPPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIWYR- 616
Query: 1993 GGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPP 2052
G L E + L IPA DAG Y C A + G A A IQ+ V A + P
Sbjct: 617 -GGLEMILAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAVGHAPQLTELP 675
Query: 2053 VKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV---HGSRLRLP---- 2105
+ +V G++ L C G VTW RRG P ++ GSR R P
Sbjct: 676 RDV-----TVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGV 729
Query: 2106 ----QVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSS 2161
V+P D YVC N G +A + V +G + + S +R
Sbjct: 730 LFFESVAPEDQAPYVCEARNVFGKVQAEARLIV-----TGHAPPQIASSAPTVR------ 778
Query: 2162 HVAEGQTLDLNCVV-PGQAHAQVTWHKRGGSLP--ARHQTHG-SLLRLHQVTPADSGEYV 2217
V EGQ + L C+V G+ + W K G LP +RH L L + +G Y
Sbjct: 779 -VLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSLHLDRALQEHAGRYS 837
Query: 2218 CHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVT 2277
C T+G V + ++ +P I P ++ EG L CV +G +T
Sbjct: 838 CVATNTAGSQHRDVELVVQ---VPPRIHPT---ATHHITNEGVPASLPCVASGVPAPTIT 891
Query: 2278 WYKRGGSLPAR----HQVRGSRLYIFQASPADAGQYVCRASNGMEAS---ITVTVTGTQG 2330
W K +L +R + + L I Q S DAG YVC A+N + S + ++V
Sbjct: 892 WTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPR 951
Query: 2331 ANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGS 2390
++ + P+++ + G+ + L+C G VTW K +P +G
Sbjct: 952 IHMNGSRNANVPLQVTAKA-----GEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGL 1006
Query: 2391 L----LRLYQASPADSGEYVC 2407
L LRL Q DSG Y C
Sbjct: 1007 LPSGSLRLAQVQVGDSGHYEC 1027
Score = 192 bits (487), Expect = 8e-48
Identities = 232/941 (24%), Positives = 354/941 (37%), Gaps = 132/941 (14%)
Query: 2523 RLSGSHSQGVAYPVRIESSSASLANGHT---LDLNCLVASQAPHTITWYKRGGSL-PSRH 2578
R+SG GVA P S A +G+ L ++C V S P + + L RH
Sbjct: 297 RVSGVSYSGVA-PGAPLVSMAPRIHGYLHQPLLVSCSVHSALPFRLQLRRGEARLGEERH 355
Query: 2579 --QIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES 2636
+ S I + + A+ G Y C + AG+ + + PP + +
Sbjct: 356 FQESGNSSWEILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDP---------PPQLVPA 406
Query: 2637 SSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH----QTHGSHLRLHQMSVADSG 2692
+ TV G+T L+C V + +TW + LP+ Q L + + D G
Sbjct: 407 PNVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGG 466
Query: 2693 EYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPG 2752
Y C A+N AS+ + V AP + I +SS H ++G + ++C G
Sbjct: 467 RYQCVASNANGVTRASVWLLVR------EAP----QVSIHTSSQHFSQGVEVKVSCSASG 516
Query: 2753 QAHAQVTWHKRGGSLPSH---HQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASV-LV 2808
++W + +L H L + V+P D+G Y C+ G + +V L
Sbjct: 517 YPTPHISWSRESQALQEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLY 576
Query: 2809 TIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP 2868
+ SAV+ VA G+ L C G +V W++ G +
Sbjct: 577 YTDPPSVSAVNAVV--------------LVAVGEEAVLVCEASGVPPPRVIWYRGGLEMI 622
Query: 2869 -ARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPI 2927
A LR+ D+G Y+C+ G A + + + G A +
Sbjct: 623 LAPEGSSSGKLRIPAAQERDAGTYTCRAVNELGDASAEIQLAV-----------GHAPQL 671
Query: 2928 YIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA-----------RHQTHGSQL 2976
V G++ L C G+ VTW +RG P Q L
Sbjct: 672 TELPRDVTVELGRSALLACRATGRPPPTVTW-RRGDGQPLGLRLGAGRGSRSRQPDSGVL 730
Query: 2977 RLHLVSPADSGEYVCRAASGPGPEQ-EASFTVT--VPPSEGSSYRLRSPVISIDPPSSTV 3033
V+P D YVC A + G Q EA VT PP SS P+ V
Sbjct: 731 FFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAPPQIASS-----------APTVRV 779
Query: 3034 QQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH--ISPNGSIITIVGTRPSNHGTYRC 3091
+GQ S C++ G W + L I +GS+ + + G Y C
Sbjct: 780 LEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADGSL-HLDRALQEHAGRYSC 838
Query: 3092 VASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISS 3151
VA+N G V L V PP + + G +L CV++G P + WT+
Sbjct: 839 VATNTAGSQHRDVELVVQVPPRIHPTATHHI-TNEGVPASLPCVASGVPAPTITWTK--E 895
Query: 3152 TPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDT------- 3204
T A + + + L I+ DAG YVC A N +G + +++ + V+T
Sbjct: 896 TNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATNTVGFSSQEMRLSVNTKPRIHMN 955
Query: 3205 GAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLP----WQHRLEG 3260
G+ P ++T +AG TL C A GSP P + W+K P+P L
Sbjct: 956 GSRNANVP------LQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVPPITNRYGLLPS 1009
Query: 3261 DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVES----PPYATTVPEHASVQAGETV 3316
+L + +V DSG Y C A++PAG A +L V+ P + VP H + +G +V
Sbjct: 1010 GSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQGRTSWQPQSLPVPHHPACLSGLSV 1069
Query: 3317 -------------QLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRY 3363
L A PP S + + +T L + P D+ +
Sbjct: 1070 PLLQPTPRSVRLCHLSLRAPLPPPFATPTSCLSQACLSSSTLSLHLSPYPLRGPGDAVQR 1129
Query: 3364 RCRVTNKVGSAEAFAQLLVQGPP------GSLPATSIPAGS 3398
+ F + V+G P GSLP T PAGS
Sbjct: 1130 PPTTQGRAQWGPGFGRTGVRGEPMKVGLRGSLPGTRGPAGS 1170
Score = 156 bits (394), Expect = 5e-37
Identities = 130/421 (30%), Positives = 172/421 (40%), Gaps = 39/421 (9%)
Query: 3265 IPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHG 3324
I R ++ + G Y C A S AG A + V PP + +V GET L C G
Sbjct: 366 ILRASKAEEGTYECTAVSRAGTGRAKAQIVVTDPPPQLVPAPNVTVSPGETAVLSCRVLG 425
Query: 3325 TPPLTFQWSRVGSSLP---GRATARNEL-LHFERAAPEDSGRYRCRVTNKVGSAEAFAQL 3380
P W R LP GR +L L P D GRY+C +N G A L
Sbjct: 426 EAPYNLTWVRDWRVLPASTGRVAQLADLSLEISGIIPTDGGRYQCVASNANGVTRASVWL 485
Query: 3381 LVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQL 3440
LV+ P V + + S G V+ C+ + W +E L
Sbjct: 486 LVR--------------EAPQVSIHTSSQHFSQGVEVKVSCSASGYPTPHISWSRESQAL 531
Query: 3441 PPG---HSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSV 3497
H G L IQ + G Y CQA G Q + L PSV + +V
Sbjct: 532 QEDSRIHVDAQGTLIIQGVAPEDAGNYSCQATNEVGTDQETVTLYYTDPPSV--SAVNAV 589
Query: 3498 QTVVVGHAVEFECLALGDPKPQVTWSKVGGH--LRPGIVQSGGVVRIAHVELADAGQYRC 3555
V VG C A G P P+V W + G L P S G +RI + DAG Y C
Sbjct: 590 VLVAVGEEAVLVCEASGVPPPRVIWYRGGLEMILAPE-GSSSGKLRIPAAQERDAGTYTC 648
Query: 3556 TATNAAGTTQSHVLLLVQALPQIS-MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGS 3614
A N G + + L V PQ++ +P++V V G +A+ C A+G P P ++W + DG
Sbjct: 649 RAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRATGRPPPTVTWRRGDGQ 708
Query: 3615 LPPDSRL-----------ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVV 3663
P RL ++ +L SV P+D YVC A N GKV+A A L V
Sbjct: 709 -PLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTGHAP 767
Query: 3664 P 3664
P
Sbjct: 768 P 768
Score = 47.0 bits (110), Expect = 4e-04
Identities = 37/116 (31%), Positives = 48/116 (41%), Gaps = 15/116 (12%)
Query: 372 QFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAI 431
++ CV+TN S H D E +PP++ I + G + CVA
Sbjct: 835 RYSCVATNTA--GSQHRDVELVVQ--------VPPRIHPTATHHI-TNEGVPASLPCVAS 883
Query: 432 GVPTPIINWRLNWGHIPSH-PRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
GVP P I W + S P V+ E GTL+I D GAY C A N G
Sbjct: 884 GVPAPTITWTKETNALTSRGPHYNVSKE---GTLLIAQPSAQDAGAYVCTATNTVG 936
Score = 46.6 bits (109), Expect = 5e-04
Identities = 32/126 (25%), Positives = 57/126 (45%), Gaps = 5/126 (3%)
Query: 402 GCMPPQVVTPPRESIQASRGQTVTFTCVAI-GVPTPIINWRLNWGHIPSHPRVTVTSEGG 460
G PPQ+ + +++ GQ V+ C+ + G P P +W + +P R ++ ++G
Sbjct: 764 GHAPPQIASSA-PTVRVLEGQPVSLPCIVLAGRPLPERHWLKDGRPLPPGSRHSIRADG- 821
Query: 461 RGTLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLP 520
+L + + G Y+C A N G + V+++ P+ P H E A LP
Sbjct: 822 --SLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHHITNEGVPASLP 879
Query: 521 CFCFGI 526
C G+
Sbjct: 880 CVASGV 885
Score = 46.2 bits (108), Expect = 7e-04
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 3/68 (4%)
Query: 419 SRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYT 478
S+G V +C A G PTP I+W + R+ V ++G TLII+ V D G Y+
Sbjct: 503 SQGVEVKVSCSASGYPTPHISWSRESQALQEDSRIHVDAQG---TLIIQGVAPEDAGNYS 559
Query: 479 CEAMNARG 486
C+A N G
Sbjct: 560 CQATNEVG 567
Score = 43.5 bits (101), Expect = 0.005
Identities = 35/112 (31%), Positives = 46/112 (41%), Gaps = 21/112 (18%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG---RGTLIIRDVKES 472
+ A G+ VT C A G P P++ W + S P +T+ G G+L + V+
Sbjct: 966 VTAKAGEEVTLDCEAKGSPPPLVTWTKD-----SRPVPPITNRYGLLPSGSLRLAQVQVG 1020
Query: 473 DQGAYTCEAMNARG-----MVFGIPDGVLELVPQRGPCPDGHFYLEHSAACL 519
D G Y C A N G V G+ G PQ P P H ACL
Sbjct: 1021 DSGHYECTASNPAGSASHRYVLGV-QGRTSWQPQSLPVP-------HHPACL 1064
Score = 40.4 bits (93), Expect = 0.039
Identities = 29/89 (32%), Positives = 36/89 (40%), Gaps = 9/89 (10%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR---- 461
PQ+ PR+ + G++ C A G P P + WR G P R+ G R
Sbjct: 669 PQLTELPRD-VTVELGRSALLACRATGRPPPTVTWRRGDGQ-PLGLRLGA-GRGSRSRQP 725
Query: 462 --GTLIIRDVKESDQGAYTCEAMNARGMV 488
G L V DQ Y CEA N G V
Sbjct: 726 DSGVLFFESVAPEDQAPYVCEARNVFGKV 754
Score = 38.5 bits (88), Expect = 0.15
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 6/84 (7%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIP-SHPRVTVTSEGGRGT 463
PPQ+V P ++ S G+T +C +G + W +W +P S RV ++ +
Sbjct: 400 PPQLVPAP--NVTVSPGETAVLSCRVLGEAPYNLTWVRDWRVLPASTGRVAQLAD---LS 454
Query: 464 LIIRDVKESDQGAYTCEAMNARGM 487
L I + +D G Y C A NA G+
Sbjct: 455 LEISGIIPTDGGRYQCVASNANGV 478
Score = 35.4 bits (80), Expect = 1.3
Identities = 22/81 (27%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P V+ + + G+ C A GVP P + W + + G L
Sbjct: 580 PPSVSAVNAVVLVAVGEEAVLVCEASGVPPPRVIW-----YRGGLEMILAPEGSSSGKLR 634
Query: 466 IRDVKESDQGAYTCEAMNARG 486
I +E D G YTC A+N G
Sbjct: 635 IPAAQERDAGTYTCRAVNELG 655
>gi|58331253 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform a [Homo sapiens]
Length = 6620
Score = 260 bits (664), Expect = 2e-68
Identities = 473/1841 (25%), Positives = 693/1841 (37%), Gaps = 356/1841 (19%)
Query: 1984 SATITWRKEGGSLPPQARSERTDIA---TLLIPAITTADAGFYLCVATSPAGTAQARIQ- 2039
+A +TW K+G +L P + E A LL+ + DAG Y CV+ Q +Q
Sbjct: 734 AAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQG 793
Query: 2040 VVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVH- 2098
+ D + V + P+ E +T AH V WY+ G L +
Sbjct: 794 LARFLHKDMAGSCVDAVAGGPAQFECET--------SEAHVHVHWYKDGMELGHSGERFL 845
Query: 2099 ----GSRLRL--PQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTR 2152
G+R RL V+ D G Y CRV G + + VS + + R
Sbjct: 846 QEDVGTRHRLVAATVTRQDEGTYSCRV--GEDSVDFRLRVS-----EPKVVFAKEQLARR 898
Query: 2153 PIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH----QTHGSLLRL--H 2206
++ E G + L+C V QA +VTW+K G L + + G RL
Sbjct: 899 KLQAE-------AGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQ 950
Query: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC 2266
Q AD+GEY C G V E V+ ++ S G + LSC
Sbjct: 951 QAGQADAGEYSCEAGGQRLSFHLDVK---EPKVV---FAKDQVAHSEVQAEAGASATLSC 1004
Query: 2267 VVAGQAHAQVTWYKRG----GSLPARHQVRG--SRLYIFQASPADAGQYVCRASNGMEAS 2320
VA QA +V WYK G SL + +G RL + QA DAG Y C A G S
Sbjct: 1005 EVA-QAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA-RGQRVS 1062
Query: 2321 ITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG-- 2378
+ +T + Q + E Q G + L+C V Q+ +VTW+K G
Sbjct: 1063 FRLHITEPK-----MMFAKEQSVHNE---VQAEAGASAMLSCEV-AQAQTEVTWYKDGKK 1113
Query: 2379 --GSLPVRHQTHGSLLRLY--QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALG 2434
S V + G RL QA AD+GEY C G V + EP G
Sbjct: 1114 LSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHI---TEPK------G 1164
Query: 2435 VTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPA----RHQVHGSRLRL 2490
V + + Q G T L+C VA Q +VTW+K G L + R +V G RL
Sbjct: 1165 VFAKEQSVHNEVQAEAGTTAMLSCEVA-QPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRL 1223
Query: 2491 L--QVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANG 2548
+ QV AD+GEY C + G + + L + + + Q V VR E+ G
Sbjct: 1224 VVQQVGKADAGEYSCE---AGGQRVSFQLHITEPKAVFAKEQLVHNEVRTEA-------G 1273
Query: 2549 HTLDLNCLVASQAPHTITWYKRGGSLPSRHQI------VGSRLRIPQVTPADSGEYVCHV 2602
+ L+C VA QA +TWYK G L S ++ +L + Q AD+GEY C
Sbjct: 1274 ASATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCE- 1331
Query: 2603 SNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIIT 2662
AG + S + + S +V ++ G L+C VA Q Q +T
Sbjct: 1332 ---AGGQRLSFHLDV-----SEPKAVFAKEQLAHRKVQAEAGAIATLSCEVA-QAQTEVT 1382
Query: 2663 WYKRGGSLPS----RHQTHGSHLRL--HQMSVADSGEYVCRANN-----NIDALEASIVI 2711
WYK G L S R + G RL Q AD+GEY C A ++D E +V
Sbjct: 1383 WYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVF 1442
Query: 2712 SVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHH 2771
+ P+ E + G + L+C V QA +V W+K G L
Sbjct: 1443 A------------KEQPVHREVQAQ---AGASTTLSCEV-AQAQTEVMWYKDGKKLSFSS 1486
Query: 2772 QTR------GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2825
+ R RL + A +GEY C GS S +HV P
Sbjct: 1487 KVRMEAVGCTRRLVVQQAGQAVAGEYSCEA-GSQ-------------RLSFHLHVAEP-K 1531
Query: 2826 APPIRIEPSSSRV--AEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH----GPLLR 2879
A + +P+S V G + L C V QA +VTW+K G L + +V G R
Sbjct: 1532 AVFAKEQPASREVQAEAGTSATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRR 1590
Query: 2880 L--NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
L + AD+GEYSC+ + V + P + A QP + E +
Sbjct: 1591 LVVQEAGQADAGEYSCKAGDQRLSFHLHV------AEPKVVFAK--EQPAHREVQAE--- 1639
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPA----RHQTHGSQLRL--HLVSPADSGEYVC 2991
G + L+C V QA +VTWYK G L + R + G RL AD+GEY C
Sbjct: 1640 AGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSC 1698
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDP---PSSTVQQGQDASFKCLIHDG 3048
A Q SF + V E P IS P V++ +D +
Sbjct: 1699 EAGG-----QRLSFRLHVAELE--------PQISERPCRREPLVVKEHEDIILTATLATP 1745
Query: 3049 AAPISLEWKTRNQELEDNVHI----------SPNGSIITIVGTRPSNHGTYRC-VASNAY 3097
+A ++ W L+D V I + +T+ G + + Y C V +
Sbjct: 1746 SA-ATVTW------LKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQ 1798
Query: 3098 GVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLE 3157
V ++ + PV ++G VTL C + P + R +T ++
Sbjct: 1799 DFPVQVEEVAAKFCRLLE-----PVCGELGGTVTLACELS--PACAEVVWRCGNTQLRVG 1851
Query: 3158 QRTYGLMDSHA-VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQA 3216
+R + + L + + DAG YVC +++ +AQ V V P + +
Sbjct: 1852 KRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSV--------PRVVKFMS 1903
Query: 3217 EEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRL------EGDTLIIPRVAQ 3270
+ + E G AT +C + S + W + + L + +L I +
Sbjct: 1904 GLSTVVAEEGGEATFQCVVSPSDVAVV-WFRDGALLQPSEKFAISQSGASHSLTISDLVL 1962
Query: 3271 QDSGQYICNATSPAGHA-----EATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGT 3325
+D+GQ A + A EA ++ + P TV E +SV T++++ L
Sbjct: 1963 EDAGQITVEAEGASSSAALRVREAPVLFKKKLEP--QTVEERSSV----TLEVE-LTRPW 2015
Query: 3326 PPLTFQWSRVGSSLPGRATARNELLHFERAAPE---------DSGRYRCRVTNKVGSAEA 3376
P L +W+R ++L A +N +H E A D G + C + A+
Sbjct: 2016 PEL--RWTRNATAL---APGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKL 2070
Query: 3377 FAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKE 3436
++ L A T T++V QL + S W ++
Sbjct: 2071 TVEMRQVRLVRGLQAVEAREQGTATMEV--QLSHADVDGS----------------WTRD 2112
Query: 3437 G---GQLPPGHSVQDG---VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVL 3490
G Q P H G L + L G + +A G SA+LV+ LP
Sbjct: 2113 GLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEG----VHTSARLVVTELP--- 2165
Query: 3491 INIRTSVQTVVV--GHAVEFECLALGDPKPQVTWSKVGGHLRPG---IVQSGGVVR---I 3542
++ +Q VV V EC L P V W K G LR G + + G R I
Sbjct: 2166 VSFSRPLQDVVTTEKEKVTLEC-ELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTI 2224
Query: 3543 AHVELADAGQYRCTATNA-------------------------------AGTTQSHVLLL 3571
E AD G Y C A +A A +S L
Sbjct: 2225 YRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLR 2284
Query: 3572 VQALPQISMPQEVR---VPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE------ 3622
V+ LP +++ + +R V C S + + W K L P + E
Sbjct: 2285 VKELP-VTLVRPLRDKIAMEKHRGVLECQVS-RASAQVRWFKGSQELQPGPKYELVSDGL 2342
Query: 3623 NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVV 3663
L++ V +D TY C A G VK A V E+ +
Sbjct: 2343 YRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQSI 2379
Score = 260 bits (664), Expect = 2e-68
Identities = 496/1972 (25%), Positives = 737/1972 (37%), Gaps = 343/1972 (17%)
Query: 1824 ILTIRNVQLSDAGTYVCT---GSNMFAMD-QGTAT-LHVQASGTLSAPVVSIHPPQLTVQ 1878
+L +R+V DAG Y C G + + QG A LH +G+ V
Sbjct: 762 VLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAVA---------- 811
Query: 1879 PGQLAEFRCSATGSPTPTLEWTG-----GPGGQLPAKAQIHGGILRLPAVEPT--DQAQY 1931
G A+F C T + W G G+ + + G RL A T D+ Y
Sbjct: 812 -GGPAQFECE-TSEAHVHVHWYKDGMELGHSGERFLQEDV-GTRHRLVAATVTRQDEGTY 868
Query: 1932 LCRAHSSAGQQVARAVLHVHGGGGPRV-----QVSPERTQVHAGRTVRLYCRAAGVPSAT 1986
CR G+ L V P+V Q++ + Q AG + L C A
Sbjct: 869 SCR----VGEDSVDFRLRV---SEPKVVFAKEQLARRKLQAEAGASATLSCEVAQA-QTE 920
Query: 1987 ITWRKEGGSLPPQAR--SERTDIA-TLLIPAITTADAGFYLCVATSPAGTAQARI-QVVV 2042
+TW K+G L ++ E T L++ ADAG Y C A + + + V
Sbjct: 921 VTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKV 980
Query: 2043 LSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRG----GSLPPHTQVH 2098
+ A D ++ S G + L+C VA A +V WY+ G SL H +
Sbjct: 981 VFAKD------QVAHSEVQAEAGASATLSCEVA-QAQTEVMWYKDGKKLSSSLKVHVEAK 1033
Query: 2099 GSRLRL--PQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRI 2156
G R RL Q D+G+Y C + S LH T + ++
Sbjct: 1034 GCRRRLVVQQAGKTDAGDYSCEARG----QRVSFR---LHITEPKMMFAKEQSVHNEVQA 1086
Query: 2157 EPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSL------LRLHQVTP 2210
E +S + L+C V QA +VTW+K G L + + + L L Q
Sbjct: 1087 EAGASAM-------LSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGK 1138
Query: 2211 ADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAG 2270
AD+GEY C G V + + G + + G T LSC VA
Sbjct: 1139 ADAGEYSCEAGG------QRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVA- 1191
Query: 2271 QAHAQVTWYKRGGSLPARHQVR------GSRLYIFQASPADAGQYVCRASNGMEASITVT 2324
Q +VTWYK G L + +VR RL + Q ADAG+Y C A G S +
Sbjct: 1192 QPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEA-GGQRVSFQLH 1250
Query: 2325 VTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG----GS 2380
+T P ++ + + G + L+C V Q+ +VTW+K G S
Sbjct: 1251 IT--------EPKAVFAKEQLVHNEVRTEAGASATLSCEV-AQAQTEVTWYKDGKKLSSS 1301
Query: 2381 LPVRHQTHGSLLRL--YQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPT 2438
VR + G + +L QA AD+GEY C G + V EP V
Sbjct: 1302 SKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDV---SEPK------AVFAK 1352
Query: 2439 VRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH------GSRLRLLQ 2492
++ Q G L+C VA QA +VTW+K G L + +V RL + Q
Sbjct: 1353 EQLAHRKVQAEAGAIATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQ 1411
Query: 2493 VTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552
AD+GEY C + G + + L + ++ + Q V V+ ++ G +
Sbjct: 1412 ACQADTGEYSCE---AGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQA-------GASTT 1461
Query: 2553 LNCLVASQAPHTITWYKRGGSL----PSRHQIVG--SRLRIPQVTPADSGEYVCHVSNGA 2606
L+C VA QA + WYK G L R + VG RL + Q A +GEY C A
Sbjct: 1462 LSCEVA-QAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCE----A 1516
Query: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVE-----GQTLDLNCVVARQPQAII 2661
GS+ S H+ P P E G + L+C VA Q Q +
Sbjct: 1517 GSQRLSF----------HLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVA-QAQTEV 1565
Query: 2662 TWYKRGGSLPS----RHQTHGSHLRL--HQMSVADSGEYVCRANNNIDALEASIVISVSP 2715
TWYK G L S R + G RL + AD+GEY C+A + + + P
Sbjct: 1566 TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHV---AEP 1622
Query: 2716 SAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR- 2774
+ ++ E+ G + L+C V QA +VTW+K G L S + R
Sbjct: 1623 KVVFAKEQPAHREVQAEA-------GASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRV 1674
Query: 2775 -----GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPI 2829
RL + AD+GEY C G V +E S P
Sbjct: 1675 EAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHV-AELEPQISER----------PC 1723
Query: 2830 RIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL--PARHQVHGP----LLRLNQV 2883
R EP V E + + L + + A VTW K G + RH+ L ++
Sbjct: 1724 RREPLV--VKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGA 1781
Query: 2884 SPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLD 2943
DS YSC+V G+ G V +E + L +P+ E G T+
Sbjct: 1782 QVLDSAIYSCRV-GAEG---QDFPVQVEEVA---AKFCRLLEPVCGEL-------GGTVT 1827
Query: 2944 LNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPA-----------DSGEYVCR 2992
L C + A A+V W R G+ R G + ++ P D+GEYVC
Sbjct: 1828 LACEL-SPACAEVVW--RCGNTQLR---VGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCE 1881
Query: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTV--QQGQDASFKCLIHDGAA 3050
+ A TV+VP V+ STV ++G +A+F+C++ +
Sbjct: 1882 SRD---DHTSAQLTVSVP-----------RVVKFMSGLSTVVAEEGGEATFQCVV--SPS 1925
Query: 3051 PISLEWKTRNQELE--DNVHISPNGS--IITIVGTRPSNHGTYRCVASNAYGVAQSVVNL 3106
+++ W L+ + IS +G+ +TI + G A A S L
Sbjct: 1926 DVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEG----ASSSAAL 1981
Query: 3107 SVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDS 3166
V P + P V+ +VTLE V P RWTR ++ A + +
Sbjct: 1982 RVREAPVLFKKKLEPQTVEERSSVTLE-VELTRPWPELRWTRNATALAPGKNVEIHAEGA 2040
Query: 3167 HAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE---AELTV 3223
L + + +D G + C + Q ++ V + + G V+A E A + V
Sbjct: 2041 RHRLVLHNVGFADRGFFGC--ETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEV 2098
Query: 3224 EAGHT----ATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICN 3279
+ H + R PT H + +R P+ TL + + +DSG +
Sbjct: 2099 QLSHADVDGSWTRDGLRFQQGPTCHLA-VRGPM--------HTLTLSGLRPEDSGLMVFK 2149
Query: 3280 ATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQW------S 3333
A H A +++ E P + + E V L+C P + +W
Sbjct: 2150 AEGV--HTSARLVV-TELPVSFSRPLQDVVTTEKEKVTLEC-ELSRPNVDVRWLKDGVEL 2205
Query: 3334 RVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATS 3393
R G ++ A L R D G Y C A++ A + VQG +L
Sbjct: 2206 RAGKTMAIAAQGACRSLTIYRCEFADQGVYVC----DAHDAQSSASVKVQGRTYTLIYRR 2261
Query: 3394 IPAGSTPTVQVT-------PQLETKSIGA----------SVEFHCAV----PSDRGTQLR 3432
+ A +Q QL K + ++E H V S Q+R
Sbjct: 2262 VLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQVR 2321
Query: 3433 WFKEGGQLPPG---HSVQDGVLR---IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQAL 3486
WFK +L PG V DG+ R I ++ + TY C A G + SAQ ++
Sbjct: 2322 WFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQ 2377
Query: 3487 PSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVE 3546
++ V TV+ FEC W L ++Q+GG V +
Sbjct: 2378 SITIVRGLQDV-TVMEPAPAWFECETSIPSVRPPKWL-----LGKTVLQAGGNVGLEQEG 2431
Query: 3547 LADAGQYRCTATN-------AAGTTQSHVLLLVQALPQI-SMPQEVRVPAG-SAAVFPCI 3597
R T + G ++S L+V +P + + P E + + V C
Sbjct: 2432 TVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCD 2491
Query: 3598 ASGYPTPDISWSKLDGSLPPDSR----LENNMLMLPSVR--PQDAGTYVCTA 3643
P + W K D L P + LE M L +R P DAG Y C A
Sbjct: 2492 FRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Score = 217 bits (553), Expect = 2e-55
Identities = 488/2084 (23%), Positives = 768/2084 (36%), Gaps = 371/2084 (17%)
Query: 1692 GSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRH--------QGSELHFPSVQPSDAGV 1743
G+ +L+C+VS H + R+DG V G ++ +G +H V P DAG+
Sbjct: 2662 GTLALQCEVSDPEAHVVW--RKDG--VQLGPSDKYDFLHTAGTRGLVVH--DVSPEDAGL 2715
Query: 1744 YICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYT 1803
Y C S +RA + V + + +T + ++ V G +F C +S +
Sbjct: 2716 YTCHV----GSEETRARVRVHDL---HVGIT-KRLKTMEVLEGESCSFECVLSHESASDP 2767
Query: 1804 LVWTRLHNGKLPTRAMDFNG-------ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLH 1856
+WT GK + F IL +R SDAG V + + A+L
Sbjct: 2768 AMWT--VGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGL----TSKASLI 2821
Query: 1857 VQASGTLSAPVVSIHP-PQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHG 1915
V+ P I P V PG+ E RC + + TP + W + K+Q +
Sbjct: 2822 VR-----ERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWL--KDRKAIRKSQKYD 2873
Query: 1916 -------GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGG------PRVQVSP 1962
+L + D +Y C +S + A LHV +QV
Sbjct: 2874 VVCEGTMAMLVIRGASLKDAGEYTCEVEASK----STASLHVEEKANCFTEELTNLQVEE 2929
Query: 1963 ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR-----SERTDIATLLIPAITT 2017
+ T V +T P+AT+TWRK G L +A S+ L I A+
Sbjct: 2930 KGTAVFTCKTEH--------PAATVTWRK--GLLELRASGKHQPSQEGLTLRLTISALEK 2979
Query: 2018 ADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGS 2077
AD+ Y C G AQ+R Q++V + + V EG + C ++ +
Sbjct: 2980 ADSDTYTC----DIGQAQSRAQLLV----QGRRVHIIEDLEDVDVQEGSSATFRCRISPA 3031
Query: 2078 AHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHG 2137
+ V W+ T +H + L ++ G +V + + + S T+ G
Sbjct: 3032 NYEPVHWFL------DKTPLHANELN--EIDAQPGGYHVLTLRQLA--LKDSGTIYFEAG 3081
Query: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL----- 2192
+ V E + + + EG+ L L C V W K G +L
Sbjct: 3082 DQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCET-STCDIPVCWTKDGKTLRGSAR 3140
Query: 2193 -PARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIES 2251
H+ H + L + T DSG Y C G +S +V + A PVR +
Sbjct: 3141 CQLSHEGHRAQLLITGATLQDSGRYKCEAGGAC----SSSIVRVHAR-------PVRFQE 3189
Query: 2252 S--SSTVAEGQTLDLSCVVAGQAHAQVTW------YKRGGSLPARHQVRGSRLYIFQASP 2303
+ V EG L CV++ A A V W + G R + L + P
Sbjct: 3190 ALKDLEVLEGGAATLRCVLSSVA-APVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRP 3248
Query: 2304 ADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCV 2363
D+G+Y C + S T+TVT A PA +R + + EG T L C
Sbjct: 3249 QDSGRYSC-SFGDQTTSATLTVT-------ALPAQFIGKLR----NKEATEGATATLRCE 3296
Query: 2364 VPGQSHAQVTWHKRGGSLP------VRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLE 2417
+ A V W K +L +R L++ + D+ EY C V G
Sbjct: 3297 L--SKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSC-VCGEE---R 3350
Query: 2418 ASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL 2477
S +TI P +PA + ES EG T L C ++ A V W K SL
Sbjct: 3351 TSASLTIRP---MPAHFIGRLRHQES-----IEGATATLRCELS--KAAPVEWRKGRESL 3400
Query: 2478 --PARHQVHGS----RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQG 2531
RH + L++ + AD+GEY C G + S +T+ + L ++G
Sbjct: 3401 RDGDRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTV-KALPAKFTEG 3455
Query: 2532 VAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV----GSR--L 2585
+ +E ++A L C ++ AP + W K +L + + G+R L
Sbjct: 3456 LRNEEAVEGATAMLW--------CELSKVAP--VEWRKGPENLRDGDRYILRQEGTRCEL 3505
Query: 2586 RIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQ 2645
+I + AD+GEY+C G TS +TI+ + + V + EG
Sbjct: 3506 QICGLAMADAGEYLC----VCGQERTSATLTIRALPARFIEDV--------KNQEAREGA 3553
Query: 2646 TLDLNCVVARQPQAIITWYKRGGSLPS------RHQTHGSHLRLHQMSVADSGEYVCRAN 2699
T L C + A + W K +L R L++ +++AD+GEY C
Sbjct: 3554 TAVLQCEL--NSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCG 3611
Query: 2700 NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESS--SSHVAEGETLDLNCVVPGQAHAQ 2757
S +++V ++PI+ + EG T L C + A
Sbjct: 3612 QE----RTSAMLTV-----------RALPIKFTEGLRNEEATEGATAVLRCEL--SKMAP 3654
Query: 2758 VTWHK-----RGGSLPSHHQTRGSR--LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTI 2810
V W K R G S Q G+R L++ + D+GEY+C G S ++T+
Sbjct: 3655 VEWWKGHETLRDGDRHSLRQD-GARCELQIRGLVAEDAGEYLC----MCGKERTSAMLTV 3709
Query: 2811 EASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHK-----RGG 2865
A S + +R E ++ EG T L C + A V W K R G
Sbjct: 3710 RAMPSKFIE--------GLRNEEAT----EGDTATLWCEL--SKAAPVEWRKGHETLRDG 3755
Query: 2866 NLPARHQVHGPL-LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLA 2924
+ + Q L++ ++ D+GEYSC V G T S +T+ +PA +
Sbjct: 3756 DRHSLRQDGSRCELQIRGLAVVDAGEYSC-VCGQERT---SATLTVR-----ALPARFIE 3806
Query: 2925 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK-----RGGS-LPARHQTHGSQLRL 2978
+ + EG T L C + A V W K RGG R +L++
Sbjct: 3807 -----DVKNQEAREGATAVLQCEL--SKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQI 3859
Query: 2979 HLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQD 3038
H +S AD+GEY C ++ S T+TV R PV S ++G
Sbjct: 3860 HGLSVADTGEYSCVCG-----QERTSATLTV--------RAPQPVFREPLQSLQAEEGST 3906
Query: 3039 ASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN----GSIITIVGTRPSNHGTYRCVAS 3094
A+ +C + + A ++ W +L+ N P + + + + + G Y C
Sbjct: 3907 ATLQCELSEPTA--TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC- 3963
Query: 3095 NAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPA 3154
G + L+V P + V G L C +S W + S
Sbjct: 3964 ---GSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHL-CCELSRAGASVEWRKGSLQLF 4019
Query: 3155 KLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV 3214
+ + A L + + DAG Y C + A V V P+
Sbjct: 4020 PCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRV---------PRPKF 4070
Query: 3215 QAEEAELTVEAGHTATLRCSATGSPA-PTIHWSK----LRSPLPWQHRLEGDT--LIIPR 3267
+ L E G A L C + + + + W K L + ++ R +G T L+I +
Sbjct: 4071 KTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQ 4130
Query: 3268 VAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP--EHASVQAGETVQLQCLAHGT 3325
+ +D+G+Y C G + L V + P T V A V A E V+ C
Sbjct: 4131 LEAKDTGEYAC----VTGGQKTAASLRV-TEPEVTIVRGLVDAEVTADEDVEFSCEVSRA 4185
Query: 3326 PPLTFQWSRVGSSLPGRAT-------ARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFA 3378
QW G L R L + PED+G V+ +G+ + A
Sbjct: 4186 GATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAG----TVSFHLGNHASSA 4241
Query: 3379 QLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGG 3438
QL V+ P T+ Q S G F C + G + RW G
Sbjct: 4242 QLTVRAP-------------EVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGV 4288
Query: 3439 QLPPGH----SVQDGVLRIQNLDQ-SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINI 3493
L +V+ G L + L + + + H G + AQL + A +V+ +
Sbjct: 4289 PLQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSFH--VGTCSSEAQLKVTAKNTVVRGL 4346
Query: 3494 RTSVQTVVVGHAVEFECLALGDPKPQVTW----SKVGGHLRPGIVQSGGVVRIAHVELAD 3549
+V+ + G A+ FEC TW V +V +R +
Sbjct: 4347 E-NVEALEGGEAL-FECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNL 4404
Query: 3550 AGQYRCTATNAAGTTQSHVLLLVQA--LPQISMPQEVRVPAGSAAVFPC-IASGYPTPDI 3606
Q C T AG + L V+ L + + V AG+ A F C ++ P +
Sbjct: 4405 RPQDSCRVTFLAGDMVTSAFLTVRGWRLEILEPLKNAAVRAGAQACFTCTLSEAVPVGEA 4464
Query: 3607 SWSKLDGSLPPD-------SRLENNMLMLPSVRPQDAG--TYVC 3641
SW ++ PD + ++ L+L S +P AG T+ C
Sbjct: 4465 SWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFAC 4508
Score = 212 bits (539), Expect = 8e-54
Identities = 438/1843 (23%), Positives = 659/1843 (35%), Gaps = 295/1843 (16%)
Query: 1670 PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR-HQG 1728
P+ + AP + P +V G +L CQ+ G+P W + D +PV +G + R Q
Sbjct: 4 PQFSGAPRFL-TRPKAFVVSVGKDATLSCQIVGNPTPQVSWEK-DQQPVAAGARFRLAQD 61
Query: 1729 SELHFPSVQP---SDAGVYICTCRNLHQSNTSRAELLV--TEAPSKPITVTVEEQRSQSV 1783
+L+ ++ D+G Y+C RN + L V A ++ + S V
Sbjct: 62 GDLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRV 121
Query: 1784 RPGADVTFICTAKSKSPAYTLVWT----RLHNGKLPTRAMDFNG---ILTIRNVQLSDAG 1836
R G++ TF C SP + W+ RL P ++ G L IR + D G
Sbjct: 122 REGSEATFRCRV-GGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG 180
Query: 1837 TYVCTGSNMFAMDQGTATLHV--QASGTLSAPVVS---------------------IHPP 1873
TY N A L V A+ T S P S PP
Sbjct: 181 TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPP 240
Query: 1874 Q-----LTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH--------GGILRL 1920
TV G+ A C TG P P W GQL + + H +L++
Sbjct: 241 STGTRTCTVTEGKHARLSCYVTGEPKPETVWK--KDGQLVTEGRRHVVYEDAQENFVLKI 298
Query: 1921 PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAA 1980
+ +D+ Y C A + GQ + ++ V P + + +V + C
Sbjct: 299 LFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVP-FKKRLQDLEVREKESATFLCEVP 357
Query: 1981 GVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITTADAGFYLCVATSPAGT-AQA 2036
PS W KE L A+ E L + ++ D Y+C + T A+
Sbjct: 358 -QPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAEL 416
Query: 2037 RIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRR------GGS 2090
+Q +L K+ + +V G T + CV V W R GG
Sbjct: 417 AVQGNLLR---------KLPRKT-AVRVGDTA-MFCVELAVPVGPVHWLRNQEEVVAGGR 465
Query: 2091 LPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGS 2150
+ + L + Q D G+ G VS P PV +
Sbjct: 466 VAISAEGTRHTLTISQCCLEDVGQVAFMA--GDCQTSTQFCVSAPRKPPLQPPVDPVVKA 523
Query: 2151 TRPIRIEPSSSHVAEGQ---TLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQ 2207
+ S S G+ T+D +V + TW + + L
Sbjct: 524 RMESSVILSWSPPPHGERPVTID-GYLVEKKKLGTYTW------IRCHEAEWVATPELTV 576
Query: 2208 VTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQ----TLD 2263
A+ G + V + S + +V P VR + EG ++D
Sbjct: 577 ADVAEEGNFQFRVSALNS-FGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVD 635
Query: 2264 LSCVVAGQAHAQVTWYKRGGSLPAR-----HQVRGSRLYIFQASPADA-GQYVCRASNGM 2317
L+ AG+ W+ G +L A H R + PA G + +NG+
Sbjct: 636 LTVASAGE------WFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGI 689
Query: 2318 EASITVTVTGTQGANL-AYPAGSTQPI--RIEPSSSQVAEGQTLDLNCVVPGQSHAQVTW 2374
E+SI + V G PA + + + R+ + +AE A VTW
Sbjct: 690 ESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAE----------LSDQAAAVTW 739
Query: 2375 HKRGGSL------PVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAG 2428
K G +L V+ +L + + D+G Y C G + + SV
Sbjct: 740 LKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSV-------- 791
Query: 2429 SVPALGVTPTVRIESSSSQV--AEGQTLDLNCLVAGQAHAQVTWHKRGGSLPAR-----H 2481
G+ + + + S V G C +AH V W+K G L
Sbjct: 792 ----QGLARFLHKDMAGSCVDAVAGGPAQFEC-ETSEAHVHVHWYKDGMELGHSGERFLQ 846
Query: 2482 QVHGSRLRLL--QVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIE 2539
+ G+R RL+ VT D G Y CRV S + RL S + V ++
Sbjct: 847 EDVGTRHRLVAATVTRQDEGTYSCRVGEDS----------VDFRLRVSEPKVVFAKEQLA 896
Query: 2540 SSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI------VGSRLRIPQVTPA 2593
G + L+C VA QA +TWYK G L S ++ RL + Q A
Sbjct: 897 RRKLQAEAGASATLSCEVA-QAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQA 955
Query: 2594 DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVV 2653
D+GEY C AG + S + ++ V ++ S G + L+C V
Sbjct: 956 DAGEYSCE----AGGQRLSFHLDVK-----EPKVVFAKDQVAHSEVQAEAGASATLSCEV 1006
Query: 2654 ARQPQAIITWYKRGGSLPSRHQTH----GSHLRL--HQMSVADSGEYVCRANNNIDALEA 2707
A Q Q + WYK G L S + H G RL Q D+G+Y C A +
Sbjct: 1007 A-QAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFRL 1065
Query: 2708 SIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSL 2767
I P ++ E+ +S + L+C V QA +VTW+K G L
Sbjct: 1066 HI---TEPKMMFAKEQSVHNEVQAEAGASAM-------LSCEV-AQAQTEVTWYKDGKKL 1114
Query: 2768 PSHH----QTRG--SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVP 2821
S + +G RL L AD+GEY C G S +H+
Sbjct: 1115 SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQ--------------RVSFHLHIT 1160
Query: 2822 APGGAPPIRIEPSSSRVAE-GQTLDLKCVVPGQAHAQVTWHKRGGNLPA----RHQVHGP 2876
P G + AE G T L C V Q +VTW+K G L + R +V G
Sbjct: 1161 EPKGVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGC 1219
Query: 2877 LLRL--NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 2934
RL QV AD+GEYSC+ G + + + + P + A Q ++ E +
Sbjct: 1220 TRRLVVQQVGKADAGEYSCEAGGQRVSFQLHI------TEPKAVFAK--EQLVHNEVRTE 1271
Query: 2935 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA----RHQTHG--SQLRLHLVSPADSGE 2988
G + L+C V QA +VTWYK G L + R + G QL + AD+GE
Sbjct: 1272 ---AGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327
Query: 2989 YVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDG 3048
Y C A G V+ P + + +L + + G A+ C +
Sbjct: 1328 YTCEAG---GQRLSFHLDVSEPKAVFAKEQLAHRKVQ-------AEAGAIATLSCEVAQA 1377
Query: 3049 AAPISLEWKTRNQELEDNVHISPNGSIITIVGTR--PSNHGTYRCVASNAYGVAQSVVNL 3106
++ + V + G +V + ++ G Y C A G + +L
Sbjct: 1378 QTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEA----GGQRLSFSL 1433
Query: 3107 SVHGPPTVSVLPEGPVWVKV----GKAVTLECVSAGEPRSSARWTRIS---STPAKLEQR 3159
V P V E PV +V G + TL C + ++ W + S +K+
Sbjct: 1434 DV-AEPKVVFAKEQPVHREVQAQAGASTTLSC-EVAQAQTEVMWYKDGKKLSFSSKVRME 1491
Query: 3160 TYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEA 3219
G V Q A AG Y C A +++ + + Q
Sbjct: 1492 AVGCTRRLVVQQAGQAV---AGEYSCEA------GSQRLSFHLHVAEPKAVFAKEQPASR 1542
Query: 3220 ELTVEAGHTATLRCSATGSPAPTIHW----SKLRSPLPWQHRLEGDT--LIIPRVAQQDS 3273
E+ EAG +ATL C + + W KL S + G T L++ Q D+
Sbjct: 1543 EVQAEAGTSATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADA 1601
Query: 3274 GQYICNATSPAGHAEATIILHVESPP--YATTVPEHASVQ--AGETVQLQC-LAHGTPPL 3328
G+Y C AG + LHV P +A P H VQ AG + L C +A +
Sbjct: 1602 GEYSCK----AGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEV 1657
Query: 3329 TFQWSRVGSSLPGRATARNEL------LHFERAAPEDSGRYRC 3365
T W + G L + R E L ++A D+G Y C
Sbjct: 1658 T--WYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSC 1698
Score = 207 bits (527), Expect = 2e-52
Identities = 419/1806 (23%), Positives = 626/1806 (34%), Gaps = 330/1806 (18%)
Query: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLS--APVVSIHPPQLTVQPGQL 1882
LTI ++ L D+G YVC N L V A + AP + P + V+ G
Sbjct: 67 LTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSE 126
Query: 1883 AEFRCSATGSPTPTLEWT------GGPGGQLPAKAQI-HGGILRLPAVEPTDQAQYLCRA 1935
A FRC GSP P + W+ G P G ++ LR+ A P D Y RA
Sbjct: 127 ATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRA 186
Query: 1936 HSSAGQQVARAVLHVHGGGGPRVQ--------------------------VSPERT---- 1965
+ G A A L V SP T
Sbjct: 187 ENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRT 246
Query: 1966 -QVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR----SERTDIATLLIPAITTADA 2020
V G+ RL C G P W+K+G + R + + L I +D
Sbjct: 247 CTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDR 306
Query: 2021 GFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080
G Y C A++ G + + VVV + P K V E ++ C V
Sbjct: 307 GLYTCTASNLVGQTYSSVLVVVREPA----VPFKKRLQDLEVREKESATFLCEVP-QPST 361
Query: 2081 QVTWY----RRGGSLPPHTQVHGS--RLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
+ W+ R S + G+ RL + VS D Y+C GS TV+
Sbjct: 362 EAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSR------TVAE 415
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKR------ 2188
L V G+ +R P + V G T + CV V W +
Sbjct: 416 L----------AVQGNL--LRKLPRKTAVRVGDTA-MFCVELAVPVGPVHWLRNQEEVVA 462
Query: 2189 GGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV- 2247
GG + + L + Q D G+ V +G + S + A P PPV
Sbjct: 463 GGRVAISAEGTRHTLTISQCCLEDVGQ----VAFMAGDCQTSTQFCVSAPRKPPLQPPVD 518
Query: 2248 -----RIESSS----STVAEGQ---TLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSR 2295
R+ESS S G+ T+D +V + TW + V
Sbjct: 519 PVVKARMESSVILSWSPPPHGERPVTID-GYLVEKKKLGTYTWIR----CHEAEWVATPE 573
Query: 2296 LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEG 2355
L + + Q+ A N S + GT +LA P++ + Q EG
Sbjct: 574 LTVADVAEEGNFQFRVSALNSFGQSPYLEFPGT--VHLAPKLAVRTPLK----AVQAVEG 627
Query: 2356 Q----TLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSG---EYVCR 2408
++DL G+ K + L + + + G ++V
Sbjct: 628 GEVTFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVAN 687
Query: 2409 VLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQV 2468
+ SS+ +E + A R+ + +AE ++ QA A V
Sbjct: 688 GIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAE---------LSDQA-AAV 737
Query: 2469 TWHKRGGSLP--ARHQVHGSR----LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522
TW K G +L +++V S L + V D+G Y C G + SV
Sbjct: 738 TWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSV------ 791
Query: 2523 RLSGSHSQGVAYPVR--IESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSR--- 2577
QG+A + + S G C S+A + WYK G L
Sbjct: 792 -------QGLARFLHKDMAGSCVDAVAGGPAQFEC-ETSEAHVHVHWYKDGMELGHSGER 843
Query: 2578 --HQIVGSRLRI--PQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIR 2633
+ VG+R R+ VT D G Y C V G S + L V S V +
Sbjct: 844 FLQEDVGTRHRLVAATVTRQDEGTYSCRV--GEDSVDFRLRV-------SEPKVVFAKEQ 894
Query: 2634 IESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH----QTHGSHLRL--HQMS 2687
+ G + L+C VA Q Q +TWYK G L S + G RL Q
Sbjct: 895 LARRKLQAEAGASATLSCEVA-QAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAG 953
Query: 2688 VADSGEYVCRANN-----NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGE 2742
AD+GEY C A ++D E +V + ++ S G
Sbjct: 954 QADAGEYSCEAGGQRLSFHLDVKEPKVVFAKD---------------QVAHSEVQAEAGA 998
Query: 2743 TLDLNCVVPGQAHAQVTWHKRG----GSLPSHHQTRGSRLRL--HHVSPADSGEYVCRVM 2796
+ L+C V QA +V W+K G SL H + +G R RL D+G+Y C
Sbjct: 999 SATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEAR 1057
Query: 2797 GSSGPL-----EASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVP 2851
G E ++ E S + V A G + L C V
Sbjct: 1058 GQRVSFRLHITEPKMMFAKEQSVHNEVQAEA------------------GASAMLSCEV- 1098
Query: 2852 GQAHAQVTWHKRGGNLPARHQVHGPL------LRLNQVSPADSGEYSCQVTGSSGTLEAS 2905
QA +VTW+K G L + +V + L L Q AD+GEYSC+ G +
Sbjct: 1099 AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLH 1158
Query: 2906 VLVTIEPSSPGPIPAPGLAQPIYIEASSSH----VTEGQTLDLNCVVPGQAHAQVTWYKR 2961
+ EP ++ + S H G T L+C V Q +VTWYK
Sbjct: 1159 I---TEPKG------------VFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKD 1202
Query: 2962 GGSLPA----RHQTHGSQLRL--HLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGS 3015
G L + R + G RL V AD+GEY C A Q SF + + +E
Sbjct: 1203 GKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGG-----QRVSFQLHI--TEPK 1255
Query: 3016 SYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSI 3075
+ + ++ + + G A+ C + ++ + V I G +
Sbjct: 1256 AVFAKEQLVHNE---VRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCM 1312
Query: 3076 --ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV---SVLPEGPVWVKVGKAV 3130
+ + ++ G Y C A G + +L V P V L V + G
Sbjct: 1313 RQLVVQQAGQADAGEYTCEA----GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIA 1368
Query: 3131 TLECVSAGEPRSSARWTRIS---STPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLA 3187
TL C + ++ W + S+ +K+ G L + A +D G Y C A
Sbjct: 1369 TLSC-EVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRR---LVVQQACQADTGEYSCEA 1424
Query: 3188 QNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK 3247
+++ +D + Q E+ +AG + TL C + + W K
Sbjct: 1425 ------GGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQT-EVMWYK 1477
Query: 3248 LRSPLPWQHRLEGDT------LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPP-- 3299
L + ++ + L++ + Q +G+Y C AG + LHV P
Sbjct: 1478 DGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCE----AGSQRLSFHLHVAEPKAV 1533
Query: 3300 YATTVPEHASVQ--AGETVQLQC-LAHGTPPLTFQWSRVGSSLPGRATARNEL------L 3350
+A P VQ AG + L C +A +T W + G L + R E L
Sbjct: 1534 FAKEQPASREVQAEAGTSATLSCEVAQAQTEVT--WYKDGKKLSSSSKVRMEAVGCTRRL 1591
Query: 3351 HFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLET 3410
+ A D+G Y C K G L V P + A PA +
Sbjct: 1592 VVQEAGQADAGEYSC----KAGDQRLSFHLHV-AEPKVVFAKEQPAHREVQAEA------ 1640
Query: 3411 KSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV------LRIQNLDQSCQGTY 3464
GAS C V + T++ W+K+G +L V+ L +Q Q+ G Y
Sbjct: 1641 ---GASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEY 1696
Query: 3465 ICQAHG 3470
C+A G
Sbjct: 1697 SCEAGG 1702
Score = 201 bits (511), Expect = 1e-50
Identities = 422/1837 (22%), Positives = 649/1837 (35%), Gaps = 291/1837 (15%)
Query: 1954 GGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATL 2010
G PR P+ V G+ L C+ G P+ ++W K+ + AR ++ D+ L
Sbjct: 8 GAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRL 67
Query: 2011 LIPAITTADAGFYLCVATSPAGTAQARI--QVVVLSASDASPPPVKIESSSPSVTEGQTL 2068
I + D+G Y+C A + G A A + QV +A P + +S V EG
Sbjct: 68 TILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEA 127
Query: 2069 DLNCVVAGSAHAQVTWYRRGGSL----PPHTQV----HGSRLRLPQVSPADSGEYVCRVE 2120
C V GS V+W + G L P +V S LR+ P D G Y R E
Sbjct: 128 TFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAE 187
Query: 2121 NGSGPKEASITVSV---------LHGTHSGPSYTPVPGSTRPIRIE------PSSS---- 2161
N G A+ + V GT + + +R E PS+
Sbjct: 188 NPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTC 247
Query: 2162 HVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH--------GSLLRLHQVTPADS 2213
V EG+ L+C V G+ + W K+ G L + H +L++ +D
Sbjct: 248 TVTEGKHARLSCYVTGEPKPETVW-KKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDR 306
Query: 2214 GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAH 2273
G Y C G +SVLV V+ P P + V E ++ C V Q
Sbjct: 307 GLYTCTASNLVGQTYSSVLV-----VVREPAVPFKKRLQDLEVREKESATFLCEVP-QPS 360
Query: 2274 AQVTWYKRGGSLPA------RHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTG 2327
+ W+K L A + RL + S D Y+C G S TV
Sbjct: 361 TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEG---SRTVAELA 417
Query: 2328 TQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR------GGSL 2381
QG NL +R P + V G T + CV V W + GG +
Sbjct: 418 VQG-NL---------LRKLPRKTAVRVGDTA-MFCVELAVPVGPVHWLRNQEEVVAGGRV 466
Query: 2382 PVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRI 2441
+ + L + Q D G+ + V +P P V P V+
Sbjct: 467 AISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPP---VDPVVKA 523
Query: 2442 ESSSSQVAEGQ---------TLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQ 2492
SS + T+D LV + TW + H+ L
Sbjct: 524 RMESSVILSWSPPPHGERPVTID-GYLVEKKKLGTYTWIR-------CHEAEWVATPELT 575
Query: 2493 VTP-ADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGH-- 2549
V A+ G + RV + ++ L G+ VR + G
Sbjct: 576 VADVAEEGNFQFRVSALNSFGQSPYL-----EFPGTVHLAPKLAVRTPLKAVQAVEGGEV 630
Query: 2550 TLDLNCLVASQAPHTITWYKRGGSL--PSRHQIVGSRLR----IPQVTPADSGEYVCHVS 2603
T ++ VAS W+ G +L S ++I R R I +V + G + V+
Sbjct: 631 TFSVDLTVASAG----EWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVA 686
Query: 2604 NGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITW 2663
NG S + G ++ P+ + E + E Q L A +TW
Sbjct: 687 NGIESSIRMEVRAAPGLTANKPPAAAAR---EVLARLHEEAQLL----AELSDQAAAVTW 739
Query: 2664 YKRGGSLP--SRHQTHGSH----LRLHQMSVADSGEYVCRANNNIDALEASIV----ISV 2713
K G +L +++ S L + ++ D+G Y C + A + S+
Sbjct: 740 LKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLH 799
Query: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT 2773
AGS + P + E +S +AH V W+K G L H
Sbjct: 800 KDMAGSCVDAVAGGPAQFECETS----------------EAHVHVHWYKDGMEL-GHSGE 842
Query: 2774 R------GSRLRL--HHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2825
R G+R RL V+ D G Y CRV E SV + S V
Sbjct: 843 RFLQEDVGTRHRLVAATVTRQDEGTYSCRVG------EDSVDFRLRVSEPKVVFAKEQLA 896
Query: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQV----HGPLLRL- 2880
++ E G + L C V QA +VTW+K G L + +V G RL
Sbjct: 897 RRKLQAE-------AGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLV 948
Query: 2881 -NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEG 2939
Q AD+GEYSC+ G + V P + A ++A + G
Sbjct: 949 VQQAGQADAGEYSCEAGGQRLSFHLDV------KEPKVVFAKDQVAHSEVQAEA-----G 997
Query: 2940 QTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH----GSQLRL--HLVSPADSGEYVCRA 2993
+ L+C V QA +V WYK G L + + H G + RL D+G+Y C A
Sbjct: 998 ASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA 1056
Query: 2994 ASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPIS 3053
Q SF + + + + +S + + G A C + ++
Sbjct: 1057 RG-----QRVSFRLHITEPKMMFAKEQSVHNEVQ-----AEAGASAMLSCEVAQAQTEVT 1106
Query: 3054 LEWKTRNQELEDNVHISPNGSI--ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
+ V + G + + ++ G Y C A G + +L + P
Sbjct: 1107 WYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA----GGQRVSFHLHITEP 1162
Query: 3112 PTVSVLPE---GPVWVKVGKAVTLECVSAGEPRSSARWTRIS---STPAKLEQRTYGLMD 3165
V + V + G L C +P++ W + S+ +K+ G
Sbjct: 1163 KGVFAKEQSVHNEVQAEAGTTAMLSC-EVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTR 1221
Query: 3166 SHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEA 3225
V Q+ A DAG Y C A + Q + T A A + Q E+ EA
Sbjct: 1222 RLVVQQVGKA---DAGEYSCEAGGQRVSFQLHI-----TEPKAVFAKE-QLVHNEVRTEA 1272
Query: 3226 GHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDT------LIIPRVAQQDSGQYICN 3279
G +ATL C + + W K L ++ + L++ + Q D+G+Y C
Sbjct: 1273 GASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCE 1331
Query: 3280 ATSPAGHAEATIILHVESPP--YATTVPEHASVQ--AGETVQLQC-LAHGTPPLTFQWSR 3334
AG + L V P +A H VQ AG L C +A +T W +
Sbjct: 1332 ----AGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVT--WYK 1385
Query: 3335 VGSSLPGRATARNEL------LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGS 3388
G L + R E L ++A D+G Y C + + L P
Sbjct: 1386 DGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCE-----AGGQRLSFSLDVAEPKV 1440
Query: 3389 LPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQD 3448
+ A P Q GAS C V + T++ W+K+G +L V+
Sbjct: 1441 VFAKEQPVHREVQAQA---------GASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRM 1490
Query: 3449 GV------LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTV-- 3500
L +Q Q+ G Y C+A G + S L + +V + + + V
Sbjct: 1491 EAVGCTRRLVVQQAGQAVAGEYSCEA----GSQRLSFHLHVAEPKAVFAKEQPASREVQA 1546
Query: 3501 VVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI---VQSGGVVR---IAHVELADAGQYR 3554
G + C + + +VTW K G L +++ G R + ADAG+Y
Sbjct: 1547 EAGTSATLSC-EVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYS 1605
Query: 3555 CTATNAAGTTQSHVL--LLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLD 3612
C A + + HV +V A Q +EV+ AG++A C + T +++W K
Sbjct: 1606 CKAGDQRLSFHLHVAEPKVVFAKEQ-PAHREVQAEAGASATLSCEVAQAQT-EVTWYKDG 1663
Query: 3613 GSLPPDSRLE------NNMLMLPSVRPQDAGTYVCTA 3643
L S++ L++ DAG Y C A
Sbjct: 1664 KKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Score = 195 bits (495), Expect = 9e-49
Identities = 429/1875 (22%), Positives = 659/1875 (35%), Gaps = 324/1875 (17%)
Query: 1865 APVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH------GGIL 1918
AP P V G+ A C G+PTP + W Q P A G +
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSW---EKDQQPVAAGARFRLAQDGDLY 65
Query: 1919 RLPAVEPT--DQAQYLCRAHSSAGQQVARAVLHVHGGG-----GPRVQVSPERTQVHAGR 1971
RL ++ D QY+CRA ++ G+ A L V P + P +V G
Sbjct: 66 RLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGS 125
Query: 1972 TVRLYCRAAGVPSATITWRKEGGSL----PPQARSERT-DIATLLIPAITTADAGFYLCV 2026
CR G P ++W K+G L P+ R E + + L I A D G Y
Sbjct: 126 EATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVR 185
Query: 2027 ATSPAGTAQARIQVVV----------------------------LSASDASPPPVKIESS 2058
A +P G A A +VV + A A P +
Sbjct: 186 AENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTR 245
Query: 2059 SPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVH--------GSRLRLPQVSPA 2110
+ +VTEG+ L+C V G + W ++ G L + H L++ +
Sbjct: 246 TCTVTEGKHARLSCYVTGEPKPETVW-KKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 2111 DSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLD 2170
D G Y C N G +S+ V V VP R +E V E ++
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLVVVRE--------PAVPFKKRLQDLE-----VREKESAT 351
Query: 2171 LNCVVPGQAHAQVTWHKRGGSLPARH----QTHGSLLRL--HQVTPADSGEYVCHVVGTS 2224
C VP Q + W K L A + G+ RL V+ D Y+C S
Sbjct: 352 FLCEVP-QPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGS 410
Query: 2225 GPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKR--- 2281
T+ + G + +R + V G T + CV V W +
Sbjct: 411 R--------TVAELAVQGNL--LRKLPRKTAVRVGDTA-MFCVELAVPVGPVHWLRNQEE 459
Query: 2282 ---GGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAG 2338
GG + + L I Q D GQ A + + S V+ + L P
Sbjct: 460 VVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGD-CQTSTQFCVSAPRKPPLQPPVD 518
Query: 2339 STQPIRIEPSS----SQVAEGQ---TLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSL 2391
R+E S S G+ T+D +V + TW + +
Sbjct: 519 PVVKARMESSVILSWSPPPHGERPVTID-GYLVEKKKLGTYTW------IRCHEAEWVAT 571
Query: 2392 LRLYQASPADSGEYVCRV-----LGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSS 2446
L A A+ G + RV G S LE V + P VR +
Sbjct: 572 PELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAP---------KLAVRTPLKAV 622
Query: 2447 QVAEGQ----TLDLNCLVAGQAHAQVTWHKRGGSLPAR--HQVHGSRLR-LLQVTPADSG 2499
Q EG ++DL AG+ W G +L A +++H R R L + +
Sbjct: 623 QAVEGGEVTFSVDLTVASAGE------WFLDGQALKASSVYEIHCDRTRHTLTIREVPAS 676
Query: 2500 EYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVAS 2559
+ ++ + E+S+ + ++ + ++ A R LA H S
Sbjct: 677 LHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAR-----EVLARLHEEAQLLAELS 731
Query: 2560 QAPHTITWYKRGGSLP--SRHQIVGSR----LRIPQVTPADSGEYVCHVSNGAGSRETSL 2613
+TW K G +L ++++ S L + V D+G Y C VS G +
Sbjct: 732 DQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYEC-VSRGG---RIAY 787
Query: 2614 IVTIQG-SGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS 2672
+++QG + H + + P E +T + + WYK G L
Sbjct: 788 QLSVQGLARFLHKDMAGSCVDAVAGGPAQFECET--------SEAHVHVHWYKDGMELGH 839
Query: 2673 R-----HQTHGSHLRLHQMSVA--DSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGS 2725
+ G+ RL +V D G Y CR D+++ + +S P +
Sbjct: 840 SGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGE--DSVDFRLRVS-EPKVVFAKEQLA 896
Query: 2726 SMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ--------TRGSR 2777
++ E+ G + L+C V QA +VTW+K G L S + TR R
Sbjct: 897 RRKLQAEA-------GASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATGCTR--R 946
Query: 2778 LRLHHVSPADSGEYVCRVMGS--SGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSS 2835
L + AD+GEY C G S L+ + A ++ S
Sbjct: 947 LVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKD---------------QVAHSE 991
Query: 2836 SRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL------LRLNQVSPADSG 2889
+ G + L C V QA +V W+K G L + +VH L + Q D+G
Sbjct: 992 VQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAG 1050
Query: 2890 EYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVP 2949
+YSC+ G V + + P + A Q ++ E + G + L+C V
Sbjct: 1051 DYSCEARGQ------RVSFRLHITEPKMMFAK--EQSVHNEVQAE---AGASAMLSCEV- 1098
Query: 2950 GQAHAQVTWYKRGGSLPARH----QTHGSQLRLHL--VSPADSGEYVCRAASGPGPEQEA 3003
QA +VTWYK G L + + G RL L AD+GEY C A Q
Sbjct: 1099 AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGG-----QRV 1153
Query: 3004 SFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL 3063
SF + + +G + +S + + G A C + ++ +
Sbjct: 1154 SFHLHITEPKGVFAKEQSVHNEVQ-----AEAGTTAMLSCEVAQPQTEVTWYKDGKKLSS 1208
Query: 3064 EDNVHISPNGSI--ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV---SVLP 3118
V + G + + ++ G Y C A G + L + P V L
Sbjct: 1209 SSKVRMEVKGCTRRLVVQQVGKADAGEYSCEA----GGQRVSFQLHITEPKAVFAKEQLV 1264
Query: 3119 EGPVWVKVGKAVTLECVSAGEPRSSARWTRIS---STPAKLEQRTYGLMDSHAVLQISSA 3175
V + G + TL C + ++ W + S+ +K+ G M L + A
Sbjct: 1265 HNEVRTEAGASATLSC-EVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQ---LVVQQA 1320
Query: 3176 KPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSA 3235
+DAG Y C A +++ +D + Q ++ EAG ATL C
Sbjct: 1321 GQADAGEYTCEA------GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEV 1374
Query: 3236 TGSPAPTIHW----SKLRSPLPWQHRLEGDT--LIIPRVAQQDSGQYICNATSPAGHAEA 3289
+ + W KL S + G T L++ + Q D+G+Y C AG
Sbjct: 1375 AQAQT-EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCE----AGGQRL 1429
Query: 3290 TIILHVESPP--YATTVPEHASV--QAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATA 3345
+ L V P +A P H V QAG + L C W + G L +
Sbjct: 1430 SFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKV 1488
Query: 3346 RNEL------LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGST 3399
R E L ++A +G Y C + GS L V P ++ A PA
Sbjct: 1489 RMEAVGCTRRLVVQQAGQAVAGEYSC----EAGSQRLSFHLHV-AEPKAVFAKEQPASRE 1543
Query: 3400 PTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV------LRI 3453
+ G S C V + T++ W+K+G +L V+ L +
Sbjct: 1544 VQAEA---------GTSATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVV 1593
Query: 3454 QNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVV---VGHAVEFEC 3510
Q Q+ G Y C+A G + S L + A P V+ V G + C
Sbjct: 1594 QEAGQADAGEYSCKA----GDQRLSFHLHV-AEPKVVFAKEQPAHREVQAEAGASATLSC 1648
Query: 3511 LALGDPKPQVTWSKVGGHLRPGI---VQSGGVVR---IAHVELADAGQYRCTATNAAGTT 3564
+ + +VTW K G L V++ G R + ADAG+Y C A G
Sbjct: 1649 -EVAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSC---EAGGQR 1704
Query: 3565 QSHVLLLVQALPQIS 3579
S L + + PQIS
Sbjct: 1705 LSFRLHVAELEPQIS 1719
Score = 191 bits (485), Expect = 1e-47
Identities = 439/1819 (24%), Positives = 661/1819 (36%), Gaps = 353/1819 (19%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGT--QQRHQGSE--LHFPSVQPSDAGV 1743
V +G S S C +S G+ V S + Q QG + L PSDAG
Sbjct: 2747 VLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGE 2806
Query: 1744 YICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICT-AKSKSPAY 1802
+ + R L TS+A L+V E P+ ++ Q V PG DV C +++ +P +
Sbjct: 2807 VVFSVRGL----TSKASLIVRERPA----AIIKPLEDQWVAPGEDVELRCELSRAGTPVH 2858
Query: 1803 TLVWTRLHNGKLPTRAMDF-----NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV 1857
W + ++ D +L IR L DAG Y C + TA+LHV
Sbjct: 2859 ---WLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCE----VEASKSTASLHV 2911
Query: 1858 QASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGG------PGGQLPAKA 1911
+ ++ L V+ A F C T P T+ W G G P++
Sbjct: 2912 EEKANCFTEELT----NLQVEEKGTAVFTCK-TEHPAATVTWRKGLLELRASGKHQPSQ- 2965
Query: 1912 QIHGGILRL--PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQV--SPERTQV 1967
G LRL A+E D Y C GQ +RA L V G RV + E V
Sbjct: 2966 --EGLTLRLTISALEKADSDTYTC----DIGQAQSRAQLLVQ---GRRVHIIEDLEDVDV 3016
Query: 1968 HAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE----RTDIATLLIPAITTADAGFY 2023
G + CR + + W + L +E L + + D+G
Sbjct: 3017 QEGSSATFRCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTI 3076
Query: 2024 LCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2083
A +A R+ P E + ++TEG+ L L C + + V
Sbjct: 3077 YFEAGDQRASAALRV--------TEKPSVFSRELTDATITEGEDLTLVCETS-TCDIPVC 3127
Query: 2084 WYRRGGSLPPHTQV------HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHG 2137
W + G +L + H ++L + + DSG Y C E G + + V
Sbjct: 3128 WTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKC--EAGGACSSSIVRV----- 3180
Query: 2138 THSGPSYTPVPGSTRPIRIEPS--SSHVAEGQTLDLNCVVPGQAHAQVTW------HKRG 2189
RP+R + + V EG L CV+ A A V W + G
Sbjct: 3181 ------------HARPVRFQEALKDLEVLEGGAATLRCVLSSVA-APVKWCYGNNVLRPG 3227
Query: 2190 GSLPARHQTHGSLLRL--HQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
R + G++L L + P DSG Y C + G S +T+ A +P
Sbjct: 3228 DKYSLRQE--GAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTA------LPAQ 3275
Query: 2248 RI-ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLP------ARHQVRGSRLYIFQ 2300
I + + EG T L C ++ A V W K +L R L I
Sbjct: 3276 FIGKLRNKEATEGATATLRCELS--KAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRG 3333
Query: 2301 ASPADAGQYVC-RASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLD 2359
+ DA +Y C AS+T+ PA +R + S EG T
Sbjct: 3334 LAMVDAAEYSCVCGEERTSASLTIR---------PMPAHFIGRLRHQES----IEGATAT 3380
Query: 2360 LNCVVPGQSHAQVTWHKRGGSL------PVRHQTHGSLLRLYQASPADSGEYVCRVLGSS 2413
L C + A V W K SL +R L++ + AD+GEY C V G
Sbjct: 3381 LRCEL--SKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSC-VCGEE 3437
Query: 2414 VPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHK- 2472
A++ V PA L + + EG T L C ++ A V W K
Sbjct: 3438 -RTSATLTVKALPAKFTEGL----------RNEEAVEGATAMLWCELS--KVAPVEWRKG 3484
Query: 2473 -----RGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGS 2527
G R + L++ + AD+GEY+C G + S +TI+
Sbjct: 3485 PENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC----VCGQERTSATLTIR------ 3534
Query: 2528 HSQGVAYPVRI--ESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS------RHQ 2579
A P R + + G T L C + S AP + W K +L R
Sbjct: 3535 -----ALPARFIEDVKNQEAREGATAVLQCELNSAAP--VEWRKGSETLRDGDRYSLRQD 3587
Query: 2580 IVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESS-- 2637
L+I + AD+GEY C G TS ++T++ + PI+
Sbjct: 3588 GTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVR----------ALPIKFTEGLR 3633
Query: 2638 SPTVVEGQTLDLNCVVARQPQAIITWYK-----RGGSLPSRHQTHG-SHLRLHQMSVADS 2691
+ EG T L C +++ A + W+K R G S Q L++ + D+
Sbjct: 3634 NEEATEGATAVLRCELSK--MAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDA 3691
Query: 2692 GEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVP 2751
GEY+C + A + + PS +R E ++ EG+T L C +
Sbjct: 3692 GEYLCMCGK--ERTSAMLTVRAMPSKFIEG-------LRNEEAT----EGDTATLWCEL- 3737
Query: 2752 GQAHAQVTWHK-----RGGSLPSHHQTRGSR--LRLHHVSPADSGEYVCRVMGSSGPLEA 2804
A V W K R G S Q GSR L++ ++ D+GEY C G
Sbjct: 3738 -SKAAPVEWRKGHETLRDGDRHSLRQD-GSRCELQIRGLAVVDAGEYSC----VCGQERT 3791
Query: 2805 SVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHK-- 2862
S +T+ A + + + + EG T L+C + A V W K
Sbjct: 3792 SATLTVRALPARFIE------------DVKNQEAREGATAVLQCEL--SKAAPVEWRKGS 3837
Query: 2863 ---RGGN-LPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPI 2918
RGG+ R L+++ +S AD+GEYSC V G T S +T+
Sbjct: 3838 ETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC-VCGQERT---SATLTVR------A 3887
Query: 2919 PAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA------RHQTH 2972
P P +P+ S EG T L C + + A V W K G L A R Q
Sbjct: 3888 PQPVFREPL----QSLQAEEGSTATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGC 3942
Query: 2973 GSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST 3032
++L L + D+GEY C S Q S T+TV + R +
Sbjct: 3943 TAELVLQDLQREDTGEYTCTCGS-----QATSATLTVTAAPVRFLR--------ELQHQE 3989
Query: 3033 VQQGQDASFKCLIHDGAAPISLEWKTRNQELED--NVHISPNGSI--ITIVGTRPSNHGT 3088
V +G A C + A S+EW+ + +L + +G+ + + G + G
Sbjct: 3990 VDEGGTAHLCCELSRAGA--SVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGD 4047
Query: 3089 YRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC-VSAGEPRSSARWT 3147
Y C G QS+ +LSV P + + G L C +S E + +W
Sbjct: 4048 YTCDT----GHTQSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWL 4103
Query: 3148 R----ISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQV---EV 3200
+ + + P K E R+ G + L I + D G Y C+ A +V EV
Sbjct: 4104 KEGVELHAGP-KYEMRSQG---ATRELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEV 4159
Query: 3201 IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG 3260
+ G + +AE+T A C + + A + W PL E
Sbjct: 4160 TIVRGLV----------DAEVT--ADEDVEFSCEVSRAGATGVQWCLQGLPLQSNEVTEV 4207
Query: 3261 -------DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP-EHASVQA 3312
TL + V +D+G + + A A+ T V +P P + +
Sbjct: 4208 AVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLT----VRAPEVTILEPLQDVQLSE 4263
Query: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNE---------LLHFERAAPEDSGRY 3363
G+ QC +W+ G +P +A N+ LL + ED+G
Sbjct: 4264 GQDASFQCRLSRASGQEARWALGG--VPLQANEMNDITVEQGTLHLLTLHKVTLEDAG-- 4319
Query: 3364 RCRVTNKVGSAEAFAQLLV 3382
V+ VG+ + AQL V
Sbjct: 4320 --TVSFHVGTCSSEAQLKV 4336
Score = 184 bits (467), Expect = 2e-45
Identities = 495/2147 (23%), Positives = 770/2147 (35%), Gaps = 405/2147 (18%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS----ELHFPSVQPSDAGVYIC 1746
G S +L C+V+ + ++ +DG+ + S + + L +DAG Y C
Sbjct: 997 GASATLSCEVAQAQTEVMWY--KDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSC 1054
Query: 1747 TCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVW 1806
R S L +TE P GA C + A T V
Sbjct: 1055 EARGQRVS----FRLHITE-PKMMFAKEQSVHNEVQAEAGASAMLSCEV---AQAQTEVT 1106
Query: 1807 TRLHNGKLPTRA---MDFNGI---LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS 1860
KL + + M+ G L + +DAG Y C + + LH+
Sbjct: 1107 WYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQ----RVSFHLHITEP 1162
Query: 1861 GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP--GGQLPAKAQIHGGIL 1918
+ A S+H ++ + G A C T + G + ++ G
Sbjct: 1163 KGVFAKEQSVHN-EVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTR 1221
Query: 1919 RLPA--VEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGG--PRVQVSPERTQVHAGRTVR 1974
RL V D +Y C A GQ+V+ LH+ + Q+ + AG +
Sbjct: 1222 RLVVQQVGKADAGEYSCEA---GGQRVSFQ-LHITEPKAVFAKEQLVHNEVRTEAGASAT 1277
Query: 1975 LYCRAAGVPSATITWRKEGGSLPPQARSERTDIA----TLLIPAITTADAGFYLCVATSP 2030
L C A + +TW K+G L ++ R + A L++ ADAG Y C
Sbjct: 1278 LSCEVAQAQTE-VTWYKDGKKLSSSSKV-RIEAAGCMRQLVVQQAGQADAGEYTC----E 1331
Query: 2031 AGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGS 2090
AG + + V S A ++ G L+C VA A +VTWY+ G
Sbjct: 1332 AGGQRLSFHLDV-SEPKAVFAKEQLAHRKVQAEAGAIATLSCEVA-QAQTEVTWYKDGKK 1389
Query: 2091 LPPHTQVHGS------RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSY 2144
L ++V RL + Q AD+GEY C +G + S ++ V
Sbjct: 1390 LSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCE----AGGQRLSFSLDVAEPK------ 1439
Query: 2145 TPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLP----ARHQTHG 2200
V +P+ E + G + L+C V QA +V W+K G L R + G
Sbjct: 1440 -VVFAKEQPVHREVQAQ---AGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRMEAVG 1494
Query: 2201 SLLRL--HQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAE 2258
RL Q A +GEY C S L + V +V P R + +
Sbjct: 1495 CTRRLVVQQAGQAVAGEYSCEA--GSQRLSFHLHVAEPKAVFAKEQPASREVQAEA---- 1548
Query: 2259 GQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR------GSRLYIFQASPADAGQYVCR 2312
G + LSC VA QA +VTWYK G L + +VR RL + +A ADAG+Y C+
Sbjct: 1549 GTSATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCK 1607
Query: 2313 ASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQV 2372
A + S + V A QP E Q G + L+C V Q+ +V
Sbjct: 1608 AGD-QRLSFHLHV-----AEPKVVFAKEQPAHRE---VQAEAGASATLSCEV-AQAQTEV 1657
Query: 2373 TWHKRG----GSLPVRHQTHGSLLRL--YQASPADSGEYVCRVLGSSVPLEASVLVTIEP 2426
TW+K G S VR + G RL QA AD+GEY C G + V +EP
Sbjct: 1658 TWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHV-AELEP 1716
Query: 2427 AGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL--PARHQ-- 2482
S P V V E + + L +A + A VTW K G + RH+
Sbjct: 1717 QISERPCRREPLV--------VKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETA 1768
Query: 2483 ---------VHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVA 2533
VHG+++ DS Y CRV ++G
Sbjct: 1769 SQGDTHTLTVHGAQV-------LDSAIYSCRV----------------------GAEGQD 1799
Query: 2534 YPVRIESSSASLAN---------GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSR 2584
+PV++E +A G T+ L C + S A + W R G+ R VG R
Sbjct: 1800 FPVQVEEVAAKFCRLLEPVCGELGGTVTLACEL-SPACAEVVW--RCGNTQLR---VGKR 1853
Query: 2585 LRIPQVTPA-----------DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIR 2633
++ P D+GEYVC + TS +T+ SV ++
Sbjct: 1854 FQMVAEGPVRSLTVLGLRAEDAGEYVCE----SRDDHTSAQLTV---------SVPRVVK 1900
Query: 2634 IESSSPTVV--EGQTLDLNCVVARQPQAIITWYKRGGSL-PSR----HQTHGSH-LRLHQ 2685
S TVV EG CVV+ A++ W++ G L PS Q+ SH L +
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSDVAVV-WFRDGALLQPSEKFAISQSGASHSLTISD 1959
Query: 2686 MSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPI----RIESSSSHVAEG 2741
+ + D+G+ I + ++ S + P+ ++E +
Sbjct: 1960 LVLEDAGQ---------------ITVEAEGASSSAALRVREAPVLFKKKLEPQTVEERSS 2004
Query: 2742 ETLDLNCVVPGQAHAQVTWHKR------GGSLPSHHQTRGSRLRLHHVSPADSGEYVCRV 2795
TL++ P ++ W + G ++ H + RL LH+V AD G + C
Sbjct: 2005 VTLEVELTRP---WPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCET 2061
Query: 2796 MGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAH 2855
+ +T+E V G + + E Q +H
Sbjct: 2062 PDD----KTQAKLTVEMRQVRLVR-----GLQAVEAREQGTATMEVQL----------SH 2102
Query: 2856 AQV--TWHKRGGNL---PARH-QVHGPL--LRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
A V +W + G P H V GP+ L L+ + P DSG V + G ++ L
Sbjct: 2103 ADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSG---LMVFKAEGVHTSARL 2159
Query: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2967
V E +P ++P+ TE + + L C + + + V W K G L A
Sbjct: 2160 VVTE------LPV-SFSRPL----QDVVTTEKEKVTLECEL-SRPNVDVRWLKDGVELRA 2207
Query: 2968 ------RHQTHGSQLRLHLVSPADSGEYVCRA----ASGPGPEQEASFTVT--------- 3008
Q L ++ AD G YVC A +S Q ++T+
Sbjct: 2208 GKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDA 2267
Query: 3009 -----VPPSEGSSYRLR---SPVISIDPPSSTV-QQGQDASFKCLIHDGAAPISLEWKTR 3059
V + S +LR PV + P + + +C + +A + W
Sbjct: 2268 GEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQV--RWFKG 2325
Query: 3060 NQELE--DNVHISPNGSI--ITIVGTRPSNHGTYRCVASNAYGVAQSVVN----LSVHGP 3111
+QEL+ + +G + I + TY C A + AQ V V G
Sbjct: 2326 SQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFFVEEQSITIVRGL 2385
Query: 3112 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQ 3171
V+V+ P W EC ++ +W + GL V +
Sbjct: 2386 QDVTVMEPAPAW--------FECETSIPSVRPPKW--LLGKTVLQAGGNVGLEQEGTVHR 2435
Query: 3172 ISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATL 3231
+ + T +G ++ ++V + P EL + L
Sbjct: 2436 LMLRR--TCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGREL-----QSVVL 2488
Query: 3232 RCSATGSPAPTIHWSKLRSPL----PWQHRLEGD--TLIIPRVAQQDSGQYICNATSPAG 3285
C +P + W K +PL ++ LEG L I R+ D+G Y C A S
Sbjct: 2489 SCDFRPAP-KAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHS 2547
Query: 3286 HAEATIILHVESPPYATTVP-EHASVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPGRA 3343
E T VE+ T P + A C L+H + +WS G +P
Sbjct: 2548 STEVT----VEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEV--EWSLNG--MPLYN 2599
Query: 3344 TARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTP--T 3401
+ +E+ H GR V + A+A G + A+S+ ++
Sbjct: 2600 DSFHEISH--------KGRRHTLVLKSIQRADA----------GIVRASSLKVSTSARLE 2641
Query: 3402 VQVTPQLETKSIG-------ASVEFHCAVPSDRGTQLRWFKEGGQLPPG------HSVQD 3448
V+V P + K++ ++ C V SD + W K+G QL P H+
Sbjct: 2642 VRVKPVVFLKALDDLSAEERGTLALQCEV-SDPEAHVVWRKDGVQLGPSDKYDFLHTAGT 2700
Query: 3449 GVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEF 3508
L + ++ G Y C G + A++ + L V I R V+ G + F
Sbjct: 2701 RGLVVHDVSPEDAGLYTCHV----GSEETRARVRVHDL-HVGITKRLKTMEVLEGESCSF 2755
Query: 3509 ECL----ALGDPKPQVTWSK-VGGHLRPGIVQSGG--VVRIAHVELADAGQYRCTATNAA 3561
EC+ + DP K VG R + G ++ + +DAG+ +
Sbjct: 2756 ECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGE---VVFSVR 2812
Query: 3562 GTTQSHVLLLVQALPQISMPQEVR-VPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR 3620
G T L++ + I P E + V G C S TP + W K ++ +
Sbjct: 2813 GLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQK 2871
Query: 3621 LE------NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPER 3661
+ ML++ +DAG Y C K+ A L V E+
Sbjct: 2872 YDVVCEGTMAMLVIRGASLKDAGEYTCEVE----ASKSTASLHVEEK 2914
Score = 181 bits (458), Expect = 2e-44
Identities = 402/1687 (23%), Positives = 616/1687 (36%), Gaps = 314/1687 (18%)
Query: 2064 EGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS------RLRLPQVSPADSGEYVC 2117
E Q++ L+C + A V WY+ L P + S LR+ ++ PAD+G Y C
Sbjct: 2482 ELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRC 2540
Query: 2118 RVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPG 2177
+ GS +TV T +GP SH E LN G
Sbjct: 2541 QA--GSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLN----G 2594
Query: 2178 QAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEA 2237
++H+ H+ L L + AD+G + + L+ S +E
Sbjct: 2595 MPLYNDSFHE------ISHKGRRHTLVLKSIQRADAG------IVRASSLKVSTSARLEV 2642
Query: 2238 SVIPGPIPPVRIESSSSTVAEGQ-TLDLSCVVAGQAHAQVTWYKRGGSLPAR------HQ 2290
V P V +++ AE + TL L C V+ A V W K G L H
Sbjct: 2643 RV----KPVVFLKALDDLSAEERGTLALQCEVS-DPEAHVVWRKDGVQLGPSDKYDFLHT 2697
Query: 2291 VRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSS 2350
L + SP DAG Y C + E V V G T+ ++ +
Sbjct: 2698 AGTRGLVVHDVSPEDAGLYTCHVGS-EETRARVRVHDLH-------VGITKRLK----TM 2745
Query: 2351 QVAEGQTLDLNCVVPGQSHAQVTWHKRGGS-------LPVRHQTHGSLLRLYQASPADSG 2403
+V EG++ CV+ +S + GG Q +L + +A+P+D+G
Sbjct: 2746 EVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAG 2805
Query: 2404 EYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQ 2463
E V V G + +AS++V PA + L VA G+ ++L C ++ +
Sbjct: 2806 EVVFSVRG--LTSKASLIVRERPAAIIKPL----------EDQWVAPGEDVELRCELS-R 2852
Query: 2464 AHAQVTWHKRGGSLPARHQ---VHGSRLRLLQVTPA---DSGEYVCRVVGSSGTQEASVL 2517
A V W K ++ + V + +L + A D+GEY C V S T
Sbjct: 2853 AGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKST------ 2906
Query: 2518 VTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYK-------R 2570
+ H + A E ++ + T C A T+TW K
Sbjct: 2907 -------ASLHVEEKANCFTEELTNLQVEEKGTAVFTCKTEHPAA-TVTWRKGLLELRAS 2958
Query: 2571 GGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
G PS+ + RL I + ADS Y C + G ++ + +QG + +
Sbjct: 2959 GKHQPSQEGLT-LRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGRRVHIIEDL-- 3011
Query: 2631 PIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH------QTHGSH-LRL 2683
V EG + C ++ + W+ L + Q G H L L
Sbjct: 3012 ------EDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLTL 3065
Query: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743
Q+++ DSG A + A++ ++ PS S E + + + EGE
Sbjct: 3066 RQLALKDSGTIYFEAGD--QRASAALRVTEKPSVFSR-----------ELTDATITEGED 3112
Query: 2744 LDLNCVVPGQAHAQVTWHKRGGSLPS------HHQTRGSRLRLHHVSPADSGEYVCRVMG 2797
L L C V W K G +L H+ ++L + + DSG Y C G
Sbjct: 3113 LTLVCET-STCDIPVCWTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCEAGG 3171
Query: 2798 SSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPS--SSRVAEGQTLDLKCVVPGQAH 2855
A SS V V A P+R + + V EG L+CV+ A
Sbjct: 3172 --------------ACSSSIVRV----HARPVRFQEALKDLEVLEGGAATLRCVLSSVA- 3212
Query: 2856 AQVTW-----HKRGGNLPARHQVHGPLLRL--NQVSPADSGEYSCQVTGSSGTLEASVLV 2908
A V W R G+ + Q G +L L + P DSG YSC T A++ V
Sbjct: 3213 APVKWCYGNNVLRPGDKYSLRQ-EGAMLELVVRNLRPQDSGRYSCSF--GDQTTSATLTV 3269
Query: 2909 TIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLP-- 2966
T P+ + + TEG T L C + A V W K +L
Sbjct: 3270 TALPAQ------------FIGKLRNKEATEGATATLRCEL--SKAAPVEWRKGSETLRDG 3315
Query: 2967 ----ARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSY-RLRS 3021
R +L++ ++ D+ EY C E+ S ++T+ P RLR
Sbjct: 3316 DRYCLRQDGAMCELQIRGLAMVDAAEYSCVCG-----EERTSASLTIRPMPAHFIGRLR- 3369
Query: 3022 PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH--ISPNGSI--IT 3077
+G A+ +C + AAP+ EW+ + L D + +G++ +
Sbjct: 3370 --------HQESIEGATATLRCEL-SKAAPV--EWRKGRESLRDGDRHSLRQDGAVCELQ 3418
Query: 3078 IVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSA 3137
I G ++ G Y CV G ++ L+V P + EG L A
Sbjct: 3419 ICGLAVADAGEYSCVC----GEERTSATLTVKALP--AKFTEG-----------LRNEEA 3461
Query: 3138 GEPRSSARWTRISS-TPAKLEQRTYGLMD----------SHAVLQISSAKPSDAGTYVCL 3186
E ++ W +S P + + L D + LQI +DAG Y+C+
Sbjct: 3462 VEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCV 3521
Query: 3187 AQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWS 3246
+A + + A V+ +EA G TA L+C S AP + W
Sbjct: 3522 CGQERTSATLTIRAL-----PARFIEDVKNQEA----REGATAVLQCE-LNSAAP-VEWR 3570
Query: 3247 K----LRSPLPWQHRLEGD--TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3300
K LR + R +G L I +A D+G+Y C G + +L V + P
Sbjct: 3571 KGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPI 3626
Query: 3301 ATTVP-EHASVQAGETVQLQCLAHGTPPLTF----QWSRVGSSLPGRATARNELLHFERA 3355
T + G T L+C P+ + + R G R L
Sbjct: 3627 KFTEGLRNEEATEGATAVLRCELSKMAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGL 3686
Query: 3356 APEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGA 3415
ED+G Y C G A L V+ ++P+ I + E + G
Sbjct: 3687 VAEDAGEYLC----MCGKERTSAMLTVR----AMPSKFIEG---------LRNEEATEGD 3729
Query: 3416 SVEFHCAVPSDRGTQLRWFKEGGQLPPG--HSV-QDG---VLRIQNLDQSCQGTYICQAH 3469
+ C + + + W K L G HS+ QDG L+I+ L G Y C
Sbjct: 3730 TATLWCEL--SKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVC- 3786
Query: 3470 GPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHL 3529
G+ + SA L ++ALP+ I Q G +C L P V W K L
Sbjct: 3787 ---GQERTSATLTVRALPARFIE-DVKNQEAREGATAVLQC-ELSKAAP-VEWRKGSETL 3840
Query: 3530 RPG----IVQSGG--VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQA-LPQISMP- 3581
R G + Q G ++I + +AD G+Y C G ++ L V+A P P
Sbjct: 3841 RGGDRYSLRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTVRAPQPVFREPL 3896
Query: 3582 QEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNM------LMLPSVRPQD 3635
Q ++ GS A C S PT + WSK L + R E + L+L ++ +D
Sbjct: 3897 QSLQAEEGSTATLQCELS-EPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQRED 3955
Query: 3636 AGTYVCT 3642
G Y CT
Sbjct: 3956 TGEYTCT 3962
Score = 164 bits (414), Expect = 2e-39
Identities = 482/2122 (22%), Positives = 739/2122 (34%), Gaps = 411/2122 (19%)
Query: 1686 SIVPQGGSHSL---RCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSE--LHFPSVQPSD 1740
+I QG SL RC+ + + D S + QG L + V D
Sbjct: 2212 AIAAQGACRSLTIYRCEFADQGVYVC-----DAHDAQSSASVKVQGRTYTLIYRRVLAED 2266
Query: 1741 AGVYICTCRNLHQSNTSRAELLVTEAPS---KPIT--VTVEEQRS----QSVRPGADVTF 1791
AG N SRA+L V E P +P+ + +E+ R Q R A V +
Sbjct: 2267 AGEIQFVAENAE----SRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQVRW 2322
Query: 1792 ICTAKSKSPA--YTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMD 1849
++ P Y LV L+ L I +V D TY C D
Sbjct: 2323 FKGSQELQPGPKYELVSDGLYRK------------LIISDVHAEDEDTYTC--------D 2362
Query: 1850 QGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP-----G 1904
G Q + + +TV A F C + +W G G
Sbjct: 2363 AGDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAG 2422
Query: 1905 GQ--LPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP 1962
G L + +H +LR T + S+ + V + P V P
Sbjct: 2423 GNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDI--------PVVLTRP 2474
Query: 1963 ERTQVHAGR---TVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIATLLIPAIT 2016
+ GR +V L C P A + W K+ L P + + + +A L I +
Sbjct: 2475 --LEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLM 2531
Query: 2017 TADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAG 2076
ADAG Y C AG+A + +V V + P++ TE +C ++
Sbjct: 2532 PADAGVYRC----QAGSAHSSTEVTVEAREVTVTGPLQ----DAEATEEGWASFSCELSH 2583
Query: 2077 SAHAQVTWYRRGGSLPP---HTQVHGSR---LRLPQVSPADSGEYVCRVENGSGPKEASI 2130
+V W G L H H R L L + AD+G + R + A +
Sbjct: 2584 EDE-EVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAG--IVRASSLKVSTSARL 2640
Query: 2131 TVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA--EGQTLDLNCVVPGQAHAQVTWHKR 2188
V V +P+ + ++ E TL L C V A V W K
Sbjct: 2641 EVRV-----------------KPVVFLKALDDLSAEERGTLALQCEV-SDPEAHVVWRKD 2682
Query: 2189 GGSLPAR------HQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPG 2242
G L H L +H V+P D+G Y CHV G E V + +
Sbjct: 2683 GVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHV----GSEETRARVRVHDLHV-- 2736
Query: 2243 PIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS-------LPARHQVRGSR 2295
+ + V EG++ CV++ ++ + + GG A Q R
Sbjct: 2737 ---GITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYI 2793
Query: 2296 LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEG 2355
L + +A+P+DAG+ V + G+ + ++ V PA +P+ VA G
Sbjct: 2794 LVVREAAPSDAGEVVF-SVRGLTSKASLIVR-------ERPAAIIKPL----EDQWVAPG 2841
Query: 2356 QTLDLNCVVPGQSHAQVTWHK------RGGSLPVRHQTHGSLLRLYQASPADSGEYVCRV 2409
+ ++L C + ++ V W K + V + ++L + AS D+GEY C V
Sbjct: 2842 EDVELRCEL-SRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEV 2900
Query: 2410 LGSSVPLEASVLVTIEPAGSVPALGVTPTVRI---ESSSSQVAEGQTLDLNCLVAGQAHA 2466
E + S +L V E ++ QV E T C A A
Sbjct: 2901 ---------------EASKSTASLHVEEKANCFTEELTNLQVEEKGTAVFTCKTEHPA-A 2944
Query: 2467 QVTWHKRGGSLPA--RHQVHGS----RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI 2520
VTW K L A +HQ RL + + ADS Y C + A +LV
Sbjct: 2945 TVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDI--GQAQSRAQLLV-- 3000
Query: 2521 QQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL------ 2574
QG + + + G + C ++ + W+ L
Sbjct: 3001 ---------QGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANELN 3051
Query: 2575 -----PSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVS 2629
P + + L + Q+ DSG + AG + S + + + PSV
Sbjct: 3052 EIDAQPGGYHV----LTLRQLALKDSGT----IYFEAGDQRASAALRV-----TEKPSV- 3097
Query: 2630 PPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS------RHQTHGSHLRL 2683
E + T+ EG+ L L C + + W K G +L H+ H + L +
Sbjct: 3098 --FSRELTDATITEGEDLTLVCETS-TCDIPVCWTKDGKTLRGSARCQLSHEGHRAQLLI 3154
Query: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESS--SSHVAEG 2741
++ DSG Y C A A +SIV + P+R + + V EG
Sbjct: 3155 TGATLQDSGRYKCEAGG---ACSSSIV------------RVHARPVRFQEALKDLEVLEG 3199
Query: 2742 ETLDLNCVVPGQAHAQVTW-----HKRGGSLPSHHQTRGSRLRL--HHVSPADSGEYVCR 2794
L CV+ A A V W R G S Q G+ L L ++ P DSG Y C
Sbjct: 3200 GAATLRCVLSSVA-APVKWCYGNNVLRPGDKYSLRQ-EGAMLELVVRNLRPQDSGRYSC- 3256
Query: 2795 VMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQA 2854
S G S +T+ A + + + + EG T L+C +
Sbjct: 3257 ---SFGDQTTSATLTVTALPAQFIG------------KLRNKEATEGATATLRCEL--SK 3299
Query: 2855 HAQVTWHK-----RGGNLPARHQVHGPL--LRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
A V W K R G+ Q G + L++ ++ D+ EYSC V G T S
Sbjct: 3300 AAPVEWRKGSETLRDGDRYCLRQ-DGAMCELQIRGLAMVDAAEYSC-VCGEERT---SAS 3354
Query: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL-- 2965
+TI P+PA + + + E+ EG T L C + A V W K SL
Sbjct: 3355 LTIR-----PMPAHFIGRLRHQES-----IEGATATLRCEL--SKAAPVEWRKGRESLRD 3402
Query: 2966 ----PARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV---PPSEGSSYR 3018
R +L++ ++ AD+GEY C E+ S T+TV P R
Sbjct: 3403 GDRHSLRQDGAVCELQICGLAVADAGEYSCVCG-----EERTSATLTVKALPAKFTEGLR 3457
Query: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN----VHISPNGS 3074
V +G A C + AP+ EW+ + L D +
Sbjct: 3458 NEEAV-----------EGATAMLWCEL-SKVAPV--EWRKGPENLRDGDRYILRQEGTRC 3503
Query: 3075 IITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC 3134
+ I G ++ G Y CV G ++ L++ P + + G L+C
Sbjct: 3504 ELQICGLAMADAGEYLCVC----GQERTSATLTIRALPARFIEDVKNQEAREGATAVLQC 3559
Query: 3135 -VSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT 3193
+++ P W + S T ++ + + LQI +D G Y C+ +
Sbjct: 3560 ELNSAAP---VEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCGQERTS 3616
Query: 3194 AQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL- 3252
A V + G +A E G TA LRC S + W K L
Sbjct: 3617 AMLTVRAL--PIKFTEGLRNEEATE-------GATAVLRCEL--SKMAPVEWWKGHETLR 3665
Query: 3253 -PWQHRLEGD----TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP-E 3306
+H L D L I + +D+G+Y+C G + +L V + P
Sbjct: 3666 DGDRHSLRQDGARCELQIRGLVAEDAGEYLC----MCGKERTSAMLTVRAMPSKFIEGLR 3721
Query: 3307 HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL--------LHFERAAPE 3358
+ G+T L C P+ +W + +L R R+ L L A
Sbjct: 3722 NEEATEGDTATLWCELSKAAPV--EWRKGHETL--RDGDRHSLRQDGSRCELQIRGLAVV 3777
Query: 3359 DSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVE 3418
D+G Y C + SA +L ++PA V+ E GA+
Sbjct: 3778 DAGEYSCVCGQERTSA-------------TLTVRALPARFIEDVKNQEARE----GATAV 3820
Query: 3419 FHCAVPSDRGTQLRWFKEGGQLPPGHSV---QDGV---LRIQNLDQSCQGTYICQAHGPW 3472
C + + + W K L G QDG L+I L + G Y C
Sbjct: 3821 LQCEL--SKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVC---- 3874
Query: 3473 GKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVG------ 3526
G+ + SA L ++A V S+Q G +C L +P V WSK G
Sbjct: 3875 GQERTSATLTVRAPQPVFREPLQSLQ-AEEGSTATLQC-ELSEPTATVVWSKGGLQLQAN 3932
Query: 3527 GHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ--ISMPQEV 3584
G P + + + ++ D G+Y CT G+ + L V A P + Q
Sbjct: 3933 GRREPRLQGCTAELVLQDLQREDTGEYTCT----CGSQATSATLTVTAAPVRFLRELQHQ 3988
Query: 3585 RVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNM------LMLPSVRPQDAGT 3638
V G A C S + W K L P ++ + L++ V +DAG
Sbjct: 3989 EVDEGGTAHLCCELS-RAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGD 4047
Query: 3639 YVCTATNRQGKVKAFAHLQVPE 3660
Y C + Q + P+
Sbjct: 4048 YTCDTGHTQSMASLSVRVPRPK 4069
Score = 153 bits (387), Expect = 3e-36
Identities = 451/1995 (22%), Positives = 706/1995 (35%), Gaps = 424/1995 (21%)
Query: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVS-IHPPQLTVQPGQLA 1883
L +RN++ D+G Y C+ F +ATL V A L A + + + T G A
Sbjct: 3241 LVVRNLRPQDSGRYSCS----FGDQTTSATLTVTA---LPAQFIGKLRNKEAT--EGATA 3291
Query: 1884 EFRCSATGSPTPTLEWTGGP-----GGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSS 1938
RC S +EW G G + + L++ + D A+Y C
Sbjct: 3292 TLRCEL--SKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSC----V 3345
Query: 1939 AGQQVARAVLHV-----HGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEG 1993
G++ A L + H G R Q S E G T L C + +A + WRK
Sbjct: 3346 CGEERTSASLTIRPMPAHFIGRLRHQESIE------GATATLRCELS--KAAPVEWRKGR 3397
Query: 1994 GSLPPQAR-SERTD--IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASP 2050
SL R S R D + L I + ADAG Y CV +A ++ +
Sbjct: 3398 ESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTSATLTVKAL--------- 3448
Query: 2051 PPVKIESS--SPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----HGSR--L 2102
P K + EG T L C + S A V W + +L + G+R L
Sbjct: 3449 -PAKFTEGLRNEEAVEGATAMLWCEL--SKVAPVEWRKGPENLRDGDRYILRQEGTRCEL 3505
Query: 2103 RLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRI--EPSS 2160
++ ++ AD+GEY+C G A++T+ L P R + +
Sbjct: 3506 QICGLAMADAGEYLCVC--GQERTSATLTIRAL-----------------PARFIEDVKN 3546
Query: 2161 SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSL--------LRLHQVTPAD 2212
EG T L C + + A V W K GS R SL L++ + AD
Sbjct: 3547 QEAREGATAVLQCEL--NSAAPVEWRK--GSETLRDGDRYSLRQDGTKCELQIRGLAMAD 3602
Query: 2213 SGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESS--SSTVAEGQTLDLSCVVAG 2270
+GEY C G S ++T+ A P++ + EG T L C ++
Sbjct: 3603 TGEYSC----VCGQERTSAMLTVRAL-------PIKFTEGLRNEEATEGATAVLRCELSK 3651
Query: 2271 QAHAQVTWYKRGGSLPA--RHQVR--GSR--LYIFQASPADAGQYVCRASNGMEASITVT 2324
A V W+K +L RH +R G+R L I DAG+Y+C S +T
Sbjct: 3652 MA--PVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKE-RTSAMLT 3708
Query: 2325 VTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL--- 2381
V A P+ + +R E + EG T L C + A V W K +L
Sbjct: 3709 VR-------AMPSKFIEGLRNE----EATEGDTATLWCEL--SKAAPVEWRKGHETLRDG 3755
Query: 2382 ---PVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPT 2438
+R L++ + D+GEY C V G S +T+ P
Sbjct: 3756 DRHSLRQDGSRCELQIRGLAVVDAGEYSC-VCGQE---RTSATLTVR---------ALPA 3802
Query: 2439 VRIESSSSQVA-EGQTLDLNCLVAGQAHAQVTWHK-----RGGSLPARHQVHGSR--LRL 2490
IE +Q A EG T L C ++ A V W K RGG + Q G+R L++
Sbjct: 3803 RFIEDVKNQEAREGATAVLQCELSKAA--PVEWRKGSETLRGGDRYSLRQ-DGTRCELQI 3859
Query: 2491 LQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPV-RIESSSASLANGH 2549
++ AD+GEY C V Q+R S + + PV R S G
Sbjct: 3860 HGLSVADTGEYSC--------------VCGQERTSATLTVRAPQPVFREPLQSLQAEEGS 3905
Query: 2550 TLDLNCLVASQAPHTITWYKRG------GSLPSRHQIVGSRLRIPQVTPADSGEYVCHVS 2603
T L C + S+ T+ W K G G R Q + L + + D+GEY C
Sbjct: 3906 TATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCT-- 3962
Query: 2604 NGAGSRETSLIVTIQGSGSSHVPSVSPPIRI--ESSSPTVVEGQTLDLNCVVARQPQAII 2661
GS+ TS +T+ + P+R E V EG T L C ++R A +
Sbjct: 3963 --CGSQATSATLTVTAA----------PVRFLRELQHQEVDEGGTAHLCCELSRAG-ASV 4009
Query: 2662 TWYKRGGSLP----SRHQT----HGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISV 2713
W K GSL +++Q + L + + D+G+Y C + S+ +
Sbjct: 4010 EWRK--GSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRV-- 4065
Query: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVP-GQAHAQVTWHKRGGSLPS--- 2769
P R++S G+ L C + ++ A V W K G L +
Sbjct: 4066 ---------PRPKFKTRLQSLEQET--GDIARLCCQLSDAESGAVVQWLKEGVELHAGPK 4114
Query: 2770 ---HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGA 2826
Q L +H + D+GEY C G AS+ VT
Sbjct: 4115 YEMRSQGATRELLIHQLEAKDTGEYACVTGGQK--TAASLRVT----------------E 4156
Query: 2827 PPIRIEPS--SSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARH---------QVHG 2875
P + I + V + ++ C V V W +G L + ++H
Sbjct: 4157 PEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIH- 4215
Query: 2876 PLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSH 2935
LRL V+P D+G S + + + + +V P + +P+
Sbjct: 4216 -TLRLKGVTPEDAGTVSFHLGNHASSAQLTVRA----------PEVTILEPL----QDVQ 4260
Query: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ-------LRLHLVSPADSGE 2988
++EGQ C + + + W G L A + L LH V+ D+G
Sbjct: 4261 LSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLEDAGT 4320
Query: 2989 YVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDG 3048
SF V SE + + +G +A F+C +
Sbjct: 4321 --------------VSFHVGTCSSEAQLKVTAKNTVVRGLENVEALEGGEALFECQLSQP 4366
Query: 3049 AAPISLEWKTRNQELEDN-VHISPNGSII----------TIVGTRPSNHGTYRCVASNAY 3097
E L+D VH S N ++ + RP + C +
Sbjct: 4367 ------EVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDS----CRVTFLA 4416
Query: 3098 GVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC-VSAGEPRSSARWTRISSTPAKL 3156
G + L+V G + P V+ G C +S P A W I+ +
Sbjct: 4417 GDMVTSAFLTVRGWRLEILEPLKNAAVRAGAQACFTCTLSEAVPVGEASWY-INGAAVQP 4475
Query: 3157 EQRTYGLM--DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV 3214
+ + + SH L + SA+P AG ++A+ +A+ V + D
Sbjct: 4476 DDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASARLTVLGLPD----------- 4524
Query: 3215 QAEEAELTVEAGHTATLRCSA---TGSPAPTIHWSKLRSPLPWQHRL-----EGDTLIIP 3266
E+AE+ + HT TL +A G + +++ Q RL G ++
Sbjct: 4525 PPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVD 4584
Query: 3267 RVAQQDSGQYICNATSPAG-----HAEATIILHVESP---PYATTVPEHASVQAGETVQL 3318
+A ++ ++ A P G H T+ L E P P + PE V AGE V L
Sbjct: 4585 GLAPGETYRFRVAAVGPVGAGEPVHLPQTVRL-AEPPKPVPPQPSAPESRQVAAGEDVSL 4643
Query: 3319 QCLAHGTPPLTFQWSRVGSSLPGR-----ATARNELLHFERAAPEDSGRYRCRVT-NKVG 3372
+ + PG + R ++L + ED G Y C + +
Sbjct: 4644 ELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHCGLAQGSIC 4703
Query: 3373 SAEAFAQLLV------QGPPGSLPATSIPAGSTPTV-QVTPQLETKSIGASVEFHCAVPS 3425
A A Q+ + + P SLP + G + + + S +++ +P
Sbjct: 4704 PAAATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLWEALARKRRMSREPTLDSISELPE 4763
Query: 3426 DRGTQLRWFKEGGQLPP----GHSVQDGVLRIQNLDQSCQG-------------TYICQA 3468
+ G R +E ++ P G+S D + R + D S TY+ +A
Sbjct: 4764 EDGRSQRLPQEAEEVAPDLSEGYSTADELARTGDADLSHTSSDDESRAGTPSLVTYLKKA 4823
Query: 3469 HGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKV--- 3525
P G + ++++ A PSV + V + LGDP K+
Sbjct: 4824 GRP-GTSPLASKVGAPAAPSVKPQQQQEPLAAVRPPLGDLSTKDLGDPSMDKAAVKIQAA 4882
Query: 3526 --GGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQE 3583
G +R + Q G + ++ G T++ V
Sbjct: 4883 FKGYKVRKEMKQQEGPM----------------FSHTFGDTEAQV--------------- 4911
Query: 3584 VRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLEN--------NMLMLPSVRPQD 3635
G A C+ + W K DG D R + L++ + D
Sbjct: 4912 -----GDALRLECVVASKADVRARWLK-DGVELTDGRHHHIDQLGDGTCSLLITGLDRAD 4965
Query: 3636 AGTYVCTATNRQGKV 3650
AG Y C +N+ G+V
Sbjct: 4966 AGCYTCQVSNKFGQV 4980
Score = 147 bits (370), Expect = 3e-34
Identities = 331/1307 (25%), Positives = 490/1307 (37%), Gaps = 250/1307 (19%)
Query: 1688 VPQGGSHSLRCQVSG--SPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYI 1745
V +GG+ +LRC +S +P + Y + +Q EL +++P D+G Y
Sbjct: 3196 VLEGGAATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYS 3255
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
C+ + T+ A L VT P++ + + R++ GA T C +P +
Sbjct: 3256 CSFGD----QTTSATLTVTALPAQ----FIGKLRNKEATEGATATLRCELSKAAP---VE 3304
Query: 1806 WTR----LHNGKLPTRAMDFNGI-LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS 1860
W + L +G D L IR + + DA Y C ++ +A+L ++
Sbjct: 3305 WRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGE----ERTSASLTIRP- 3359
Query: 1861 GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP----GGQLPAKAQIHGG 1916
+ A + Q +++ G A RC S +EW G G + Q G
Sbjct: 3360 --MPAHFIGRLRHQESIE-GATATLRCEL--SKAAPVEWRKGRESLRDGDRHSLRQ-DGA 3413
Query: 1917 I--LRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVR 1974
+ L++ + D +Y C G++ A L V + V G T
Sbjct: 3414 VCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPAKFTEGLRNEEAVE-GATAM 3468
Query: 1975 LYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT---LLIPAITTADAGFYLCVATSPA 2031
L+C + V A + WRK +L R T L I + ADAG YLCV
Sbjct: 3469 LWCELSKV--APVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVCGQER 3526
Query: 2032 GTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL 2091
+A I+ A P + + EG T L C + ++ A V W R GS
Sbjct: 3527 TSATLTIR--------ALPARFIEDVKNQEAREGATAVLQCEL--NSAAPVEW--RKGS- 3573
Query: 2092 PPHTQVHGSRLRLPQ-----------VSPADSGEYVCRVENGSGPKEASITVSVLHGTHS 2140
T G R L Q ++ AD+GEY C G A +TV L
Sbjct: 3574 --ETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVC--GQERTSAMLTVRAL----- 3624
Query: 2141 GPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK-----RGGSLPAR 2195
P+ T +R E ++ EG T L C + A V W K R G +
Sbjct: 3625 -----PIK-FTEGLRNEEAT----EGATAVLRCELSKMA--PVEWWKGHETLRDGDRHSL 3672
Query: 2196 HQTHGSL-LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSS 2254
Q L++ + D+GEY+C G S ++T+ A +P IE +
Sbjct: 3673 RQDGARCELQIRGLVAEDAGEYLC----MCGKERTSAMLTVRA------MPSKFIEGLRN 3722
Query: 2255 TVA-EGQTLDLSCVVAGQAHAQVTWYKRGGSLPA--RHQVR--GSR--LYIFQASPADAG 2307
A EG T L C ++ A V W K +L RH +R GSR L I + DAG
Sbjct: 3723 EEATEGDTATLWCELSKAA--PVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAG 3780
Query: 2308 QYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ 2367
+Y C S T+TV A PA + ++ + + EG T L C +
Sbjct: 3781 EYSCVCGQE-RTSATLTVR-------ALPARFIEDVK----NQEAREGATAVLQCEL--S 3826
Query: 2368 SHAQVTWHK-----RGGS-LPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVL 2421
A V W K RGG +R L+++ S AD+GEY C V G S
Sbjct: 3827 KAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC-VCGQE---RTSAT 3882
Query: 2422 VTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPA-- 2479
+T+ P R S Q EG T L C ++ + A V W K G L A
Sbjct: 3883 LTVRAP--------QPVFREPLQSLQAEEGSTATLQCELS-EPTATVVWSKGGLQLQANG 3933
Query: 2480 ----RHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYP 2535
R Q + L L + D+GEY C + G+Q S +T+ A P
Sbjct: 3934 RREPRLQGCTAELVLQDLQREDTGEYTC----TCGSQATSATLTV-----------TAAP 3978
Query: 2536 VRI--ESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP----SRHQIV----GSRL 2585
VR E + G T L C S+A ++ W K GSL +++Q+V + L
Sbjct: 3979 VRFLRELQHQEVDEGGTAHL-CCELSRAGASVEWRK--GSLQLFPCAKYQMVQDGAAAEL 4035
Query: 2586 RIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQ 2645
+ V D+G+Y C + Q S V P + S G
Sbjct: 4036 LVRGVEQEDAGDYTCDTGH------------TQSMASLSVRVPRPKFKTRLQSLEQETGD 4083
Query: 2646 TLDLNCVVA-RQPQAIITWYKRGGSLPS------RHQTHGSHLRLHQMSVADSGEYVCRA 2698
L C ++ + A++ W K G L + R Q L +HQ+ D+GEY C
Sbjct: 4084 IARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYAC-- 4141
Query: 2699 NNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQV 2758
V +A S + I + V E ++ +C V V
Sbjct: 4142 -----------VTGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGV 4190
Query: 2759 TWHKRGGSLPSHHQT-------RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
W +G L S+ T R LRL V+P D+G V G +S +T+
Sbjct: 4191 QWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAG----TVSFHLGNHASSAQLTVR 4246
Query: 2812 ASGSSAVHVPAPGGAPPIRI-EP-SSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA 2869
AP + I EP +++EGQ +C + + + W G L A
Sbjct: 4247 --------------APEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQA 4292
Query: 2870 R-------HQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVT 2909
Q LL L++V+ D+G S V S EA + VT
Sbjct: 4293 NEMNDITVEQGTLHLLTLHKVTLEDAGTVSFHVGTCSS--EAQLKVT 4337
Score = 133 bits (334), Expect = 4e-30
Identities = 290/1356 (21%), Positives = 471/1356 (34%), Gaps = 226/1356 (16%)
Query: 2431 PALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGS---- 2486
P P + V+ G+ L+C + G QV+W K + A + +
Sbjct: 4 PQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGD 63
Query: 2487 --RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSAS 2544
RL +L + DSG+YVCR + G A+V + + + + A + +S
Sbjct: 64 LYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQ---APHFLLRPTSIR 120
Query: 2545 LANGHTLDLNCLVASQAPHTITWYKRGGSLPS------RHQIVG--SRLRIPQVTPADSG 2596
+ G C V ++W K G L R + +G S LRI P D G
Sbjct: 121 VREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG 180
Query: 2597 EYVCHVSN--GAGSRETSLIVTIQGSGSSHVPSVS------------PPIRIES--SSP- 2639
Y N GA S +L+V + ++ P S +R E +SP
Sbjct: 181 TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPP 240
Query: 2640 -------TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSH--------LRLH 2684
TV EG+ L+C V +P+ W K+ G L + + H + L++
Sbjct: 241 STGTRTCTVTEGKHARLSCYVTGEPKPETVW-KKDGQLVTEGRRHVVYEDAQENFVLKIL 299
Query: 2685 QMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETL 2744
+D G Y C A+N + +S+++ V A +P + V E E+
Sbjct: 300 FCKQSDRGLYTCTASNLVGQTYSSVLVVVREPA---------VPFKKRLQDLEVREKESA 350
Query: 2745 DLNCVVPGQAHAQVTWHKRGGSLPS------HHQTRGSRLRLHHVSPADSGEYVCRVMGS 2798
C VP Q + W K L + + RL + +VS D Y+C
Sbjct: 351 TFLCEVP-QPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICET--- 406
Query: 2799 SGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQV 2858
P + + + G+ +R P + V G T + CV V
Sbjct: 407 --PEGSRTVAELAVQGNL------------LRKLPRKTAVRVGDTA-MFCVELAVPVGPV 451
Query: 2859 TWHKR------GGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEP 2912
W + GG + + L ++Q D G QV +G + S +
Sbjct: 452 HWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVG----QVAFMAGDCQTSTQFCVSA 507
Query: 2913 SSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGS---LPARH 2969
P+ P P+ S V + + P + K+ G+ +
Sbjct: 508 PRKPPLQPP--VDPVVKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHE 565
Query: 2970 QTHGSQLRLHLVSPADSGEYVCRAAS----GPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3025
+ L + A+ G + R ++ G P E TV + +P ++
Sbjct: 566 AEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHL-----------APKLA 614
Query: 3026 IDPPSSTVQ--QGQDASFKCLIHDGAAPISLEWKTRNQELEDN----VHISPNGSIITIV 3079
+ P VQ +G + +F D + EW Q L+ + +H +TI
Sbjct: 615 VRTPLKAVQAVEGGEVTFSV---DLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIR 671
Query: 3080 GTRPSNHGTYRCVASNAYGVAQSV-------VNLSVHGPPTVSVLPEGPVWVKVGKAVTL 3132
S HG +N G+ S+ L+ + PP + V ++ + L
Sbjct: 672 EVPASLHGAQLKFVAN--GIESSIRMEVRAAPGLTANKPPAAAA---REVLARLHEEAQL 726
Query: 3133 ECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALG 3192
+ ++ W + T + + VL + DAG Y C+++
Sbjct: 727 -LAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRI 785
Query: 3193 TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE--AGHTATLRCSATGSPAPTIHWSK--- 3247
Q V+ + A + + A V+ AG A C T +HW K
Sbjct: 786 AYQLSVQGL---------ARFLHKDMAGSCVDAVAGGPAQFECE-TSEAHVHVHWYKDGM 835
Query: 3248 ---------LRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESP 3298
L+ + +HRL T V +QD G Y C G L V P
Sbjct: 836 ELGHSGERFLQEDVGTRHRLVAAT-----VTRQDEGTYSCR----VGEDSVDFRLRVSEP 886
Query: 3299 PYATTVPEHA----SVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPG------RATARN 3347
+ A +AG + L C +A +T W + G L AT
Sbjct: 887 KVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVT--WYKDGKKLSSSSKVCMEATGCT 944
Query: 3348 ELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQ 3407
L ++A D+G Y C + G L V+ P QV
Sbjct: 945 RRLVVQQAGQADAGEYSC----EAGGQRLSFHLDVKEPKVVFAKD----------QVAHS 990
Query: 3408 LETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG---HSVQDGVLR---IQNLDQSCQ 3461
GAS C V + T++ W+K+G +L H G R +Q ++
Sbjct: 991 EVQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDA 1049
Query: 3462 GTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLA--LGDPKPQ 3519
G Y C+A G + S +L I P ++ SV V A L+ + + +
Sbjct: 1050 GDYSCEARG----QRVSFRLHITE-PKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTE 1104
Query: 3520 VTWSKVGGHL----RPGIVQSGGVVRIA--HVELADAGQYRCTATNAAGTTQSHVLLLVQ 3573
VTW K G L + G+ G R+ ADAG+Y C A + H+
Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHITEPKG 1164
Query: 3574 AL-PQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE------NNML 3626
+ S+ EV+ AG+ A+ C + P +++W K L S++ L
Sbjct: 1165 VFAKEQSVHNEVQAEAGTTAMLSCEVA-QPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRL 1223
Query: 3627 MLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERV 3662
++ V DAG Y C A + +V H+ P+ V
Sbjct: 1224 VVQQVGKADAGEYSCEAGGQ--RVSFQLHITEPKAV 1257
Score = 105 bits (263), Expect = 8e-22
Identities = 212/933 (22%), Positives = 331/933 (35%), Gaps = 134/933 (14%)
Query: 2821 PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA----RHQVHGP 2876
P GAP P + V+ G+ L C + G QV+W K + A R G
Sbjct: 4 PQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGD 63
Query: 2877 LLRLN--QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 2934
L RL ++ DSG+Y C+ + G A+V + ++ + AP + +S
Sbjct: 64 LYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAP----HFLLRPTSI 119
Query: 2935 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL--------PARHQTHGSQLRLHLVSPADS 2986
V EG C V G V+W K G L S LR+ P D
Sbjct: 120 RVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDG 179
Query: 2987 GEYVCRAASGPGPEQEASFTVTVPPSEGSSYR------------------LRSPVISIDP 3028
G Y RA + G A+ V + ++ R +R+ P
Sbjct: 180 GTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASP 239
Query: 3029 PSS-----TVQQGQDASFKCLIHDGAAPISLEWKTRNQEL-EDNVHI----SPNGSIITI 3078
PS+ TV +G+ A C + P ++ WK Q + E H+ + ++ I
Sbjct: 240 PSTGTRTCTVTEGKHARLSCYVTGEPKPETV-WKKDGQLVTEGRRHVVYEDAQENFVLKI 298
Query: 3079 VGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAG 3138
+ + S+ G Y C ASN G S V + V P + V+ ++ T C
Sbjct: 299 LFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLC-EVP 357
Query: 3139 EPRSSARWTRISSTPAKLEQRTYGLMD--SHAVLQISSAKPSDAGTYVCLAQNALGTAQK 3196
+P + A W YG+ + + L + + D Y+C +
Sbjct: 358 QPSTEAAW--FKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPE----GSR 411
Query: 3197 QVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQH 3256
V + G + P+ A V G TA + C P +HW + + +
Sbjct: 412 TVAELAVQGNLLRKLPRKTA------VRVGDTA-MFCVELAVPVGPVHWLRNQEEVVAGG 464
Query: 3257 RL----EG--DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE---- 3306
R+ EG TL I + +D GQ AG + + V +P P
Sbjct: 465 RVAISAEGTRHTLTISQCCLEDVGQ----VAFMAGDCQTSTQFCVSAPRKPPLQPPVDPV 520
Query: 3307 -HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRAT----------ARNELLHFERA 3355
A +++ + HG P+T V G T A EL + A
Sbjct: 521 VKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVA 580
Query: 3356 APEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGA 3415
+ G ++ RV+ + +F Q PG++ A TP ++ +E +
Sbjct: 581 ---EEGNFQFRVS----ALNSFGQSPYLEFPGTVHLAPKLAVRTP-LKAVQAVEGGEVTF 632
Query: 3416 SVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ------DGVLRIQNLDQSCQGTYI-CQA 3468
SV+ A + WF +G L + L I+ + S G + A
Sbjct: 633 SVDLTVASAGE------WFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVA 686
Query: 3469 HGPWGKAQASAQLVIQALPSVLIN--IRTSVQTVVVGHAVEFECLA-LGDPKPQVTWSKV 3525
+G ++S ++ ++A P + N + + V+ E + LA L D VTW K
Sbjct: 687 NG----IESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKD 742
Query: 3526 GGHLRPG----IVQSGG--VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS 3579
G L PG + S G V+ + V DAG Y C + Q V L + L +
Sbjct: 743 GRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDM 802
Query: 3580 MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL-------ENNMLMLPSVR 3632
V AG A F C S + W K L + L+ +V
Sbjct: 803 AGSCVDAVAGGPAQFECETSEAHV-HVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVT 861
Query: 3633 PQDAGTYVCTATNRQGKVKAFAHLQVPERVVPY 3665
QD GTY C R G+ L+V E V +
Sbjct: 862 RQDEGTYSC----RVGEDSVDFRLRVSEPKVVF 890
Score = 93.2 bits (230), Expect = 5e-18
Identities = 316/1508 (20%), Positives = 494/1508 (32%), Gaps = 288/1508 (19%)
Query: 1696 LRCQVSGSPPHYFYWSREDGRPVPSGT--QQRHQGS--ELHFPSVQPSDAGVYICTCRNL 1751
L CQ+S + ++G + +G + R QG+ EL ++ D G Y C
Sbjct: 4087 LCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYACVTGG- 4145
Query: 1752 HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
+ A L VTE P V V DV F C S++ A + W
Sbjct: 4146 ---QKTAASLRVTE----PEVTIVRGLVDAEVTADEDVEFSCEV-SRAGATGVQWCLQG- 4196
Query: 1812 GKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV-----QASGTLSAP 1866
LP ++ + + V + D + + D GT + H+ A T+ AP
Sbjct: 4197 --LPLQSNE------VTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRAP 4248
Query: 1867 VVSIHPPQLTVQ--PGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVE 1924
V+I P VQ GQ A F+C + + W G +P +A + +
Sbjct: 4249 EVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGG---VPLQAN------EMNDIT 4299
Query: 1925 PTDQAQYLCRAHSSAGQQVARAVLHVHG-GGGPRVQVSPERTQVHA--------GRTVRL 1975
+L H + HV +++V+ + T V G
Sbjct: 4300 VEQGTLHLLTLHKVTLEDAGTVSFHVGTCSSEAQLKVTAKNTVVRGLENVEALEGGEALF 4359
Query: 1976 YCRAAGVPSATITWRKEGGSLPPQARSERTDIA--------TLLIPAITTADAGFYLCVA 2027
C+ + A TW + P SE ++ LL+ + D+ C
Sbjct: 4360 ECQLSQPEVAAHTWLLDD---EPVHTSENAEVVFFENGLRHLLLLKNLRPQDS----CRV 4412
Query: 2028 TSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA-QVTWYR 2086
T AG + V P+K + +V G C ++ + + +WY
Sbjct: 4413 TFLAGDMVTSAFLTVRGWRLEILEPLK----NAAVRAGAQACFTCTLSEAVPVGEASWYI 4468
Query: 2087 RGGSLPPHTQ-----VHGSR--LRLPQVSPADSGE--YVCRVENGSGPKEASITVSVLHG 2137
G ++ P GS L L P +GE + CR AS ++VL
Sbjct: 4469 NGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACR------DAVASARLTVLG- 4521
Query: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL----- 2192
+P + SSH T+ L+ P GG L
Sbjct: 4522 ---------LPDPPEDAEVVARSSH-----TVTLSWAAP--------MSDGGGGLCGYRV 4559
Query: 2193 PARHQTHGSLLRLHQVTPADS--------GEYVCHVVGTSGPLEASVLV----TIEASVI 2240
+ G H++ P GE V GP+ A V T+ +
Sbjct: 4560 EVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEP 4619
Query: 2241 PGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKR------GGSLPARHQVRGS 2294
P P+PP S VA G+ + L V +A +V W+K GG Q R
Sbjct: 4620 PKPVPPQPSAPESRQVAAGEDVSLELEVVAEA-GEVIWHKGMERIQPGGRFEVVSQGRQQ 4678
Query: 2295 RLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAE 2354
L I + D G+Y C + G PA +T + + P+S A
Sbjct: 4679 MLVIKGFTAEDQGEYHCGLAQGSIC----------------PAAATFQVALSPASVDEAP 4722
Query: 2355 GQTLDLNCVVPGQSHA--QVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGS 2412
+L G H + KR S R T S+ L P + G
Sbjct: 4723 QPSLPPEAAQEGDLHLLWEALARKRRMS---REPTLDSISEL----PEEDGR------SQ 4769
Query: 2413 SVPLEASVLVT-----IEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQ 2467
+P EA + A + G S A +L AG+
Sbjct: 4770 RLPQEAEEVAPDLSEGYSTADELARTGDADLSHTSSDDESRAGTPSLVTYLKKAGRPGTS 4829
Query: 2468 VTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI-----QQ 2522
K G + + L V P G+ + +G +A+V + +
Sbjct: 4830 PLASKVGAPAAPSVKPQQQQEPLAAVRPP-LGDLSTKDLGDPSMDKAAVKIQAAFKGYKV 4888
Query: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS-RHQIV 2581
R +G + + A + G L L C+VAS+A W K G L RH +
Sbjct: 4889 RKEMKQQEGPMFSHTFGDTEAQV--GDALRLECVVASKADVRARWLKDGVELTDGRHHHI 4946
Query: 2582 GS------RLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPI--- 2632
L I + AD+G Y C VSN G S V + GS S S +
Sbjct: 4947 DQLGDGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDA 5006
Query: 2633 ----------RIESSSPTVVEGQTLDLNCVVA-RQPQAIITWYKRGGSLPSRHQTHGSHL 2681
+ SP V + L L+ +P+ W R H +
Sbjct: 5007 FRRAARRLHRLFRTKSPAEVSDEELFLSADEGPAEPEEPADWQ------TYREDEHFICI 5060
Query: 2682 RLHQMSVADSGEYVCRANNNIDALEASIVIS------------VSPSAGSPSAPGSSMPI 2729
R ++ ++ + V R L + I +S +P P +P
Sbjct: 5061 RFE--ALTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPS 5118
Query: 2730 RIESSSS----------HVAEGETLDLNCVVPGQAHAQVTWHKRGGSLP-------SHHQ 2772
+ S ++ V +G + +CVV GQ V W K G L + Q
Sbjct: 5119 LLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQ 5178
Query: 2773 TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGS----------SAVHVPA 2822
G +L + V PAD G Y C S G + ++ + + S+ + A
Sbjct: 5179 QGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSA 5238
Query: 2823 PGGAPPIRIEPSSSRVAEGQ-------TLDLKCV-----------VPGQAHAQVTWHKRG 2864
G E + S EGQ DL+ V G ++ W K G
Sbjct: 5239 QGYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDG 5298
Query: 2865 GNLPARHQVHGP------LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE-PSSPGP 2917
L A + L + V+ DSG+Y+ ++ + G +S + + P P
Sbjct: 5299 QPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEE 5358
Query: 2918 IPAPG----LAQPIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQVTWYKR----------- 2961
PA L P +E + V +G ++ + V G+ V W +
Sbjct: 5359 KPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGP 5418
Query: 2962 ---GGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSEGSSY 3017
G ++ + Q H L L V G Y C A++ G AS V+ P
Sbjct: 5419 DTPGYTVASSAQQH--SLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLPKVEEQE 5476
Query: 3018 RLRSPVIS 3025
+++ +IS
Sbjct: 5477 KVKEALIS 5484
Score = 85.5 bits (210), Expect = 1e-15
Identities = 61/193 (31%), Positives = 83/193 (43%), Gaps = 23/193 (11%)
Query: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQ--HRLEGD-----TLI 3264
P + E A+ T E G T L C TG+P P I W K + H L D LI
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 3265 IPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHG 3324
+ + DSGQY+C A S AG+ + V+ PP + GE Q C G
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEG 6133
Query: 3325 TPPLTFQWSRVGSSLPGRATARNE------------LLHFERAAPEDSGRYRCRVTNKVG 3372
P +W + G+ L T N+ +L A+ ED G Y C + N++G
Sbjct: 6134 APYPQIRWYKDGALL----TTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLG 6189
Query: 3373 SAEAFAQLLVQGP 3385
SA A A+L +Q P
Sbjct: 6190 SARASAELRIQSP 6202
Score = 84.7 bits (208), Expect = 2e-15
Identities = 131/581 (22%), Positives = 197/581 (33%), Gaps = 119/581 (20%)
Query: 2741 GETLDLNCVVPGQAHAQVTWHKRGGSLPS---HHQTR----GSRLRLHHVSPADSGEYVC 2793
G+ L L CVV +A + W K G L HH + L + + AD+G Y C
Sbjct: 4912 GDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYTC 4971
Query: 2794 RVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRV-------AEGQTLDL 2846
+V G + S V + SGS + + GG ++ R+ + + D
Sbjct: 4972 QVSNKFGQVTHSACVVV--SGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSDE 5029
Query: 2847 KCVV-----PGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGT 2901
+ + P + W R H +R ++ A Q ++
Sbjct: 5030 ELFLSADEGPAEPEEPADWQTY------REDEHFICIRFEALTEARQAVTRFQEMFATLG 5083
Query: 2902 LEASVLVT----------IEPSSPGPI----PAPGL----AQPIYI-EASSSHVTEGQTL 2942
+ + + I +P P+ P P L A P+++ E + V +G +
Sbjct: 5084 IGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPV 5143
Query: 2943 DLNCVVPGQAHAQVTWYKRGGSLPA-------RHQTHGSQLRLHLVSPADSGEYVCRAAS 2995
+CVV GQ V W+K G L Q G QL + V PAD G Y C A +
Sbjct: 5144 SFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAEN 5203
Query: 2996 GPGPEQ----------EASFTVTVPPSEGSSYRLRSPVISI---DPPSSTVQQGQD---- 3038
G + +E SSY +S + ST +GQ
Sbjct: 5204 SMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVV 5263
Query: 3039 --------------ASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIIT----IVG 3080
A F+ + AP L W Q L + HI I I+
Sbjct: 5264 EELRDLQVAPGTRLAKFQLKVKGYPAP-RLYWFKDGQPLTASAHIRMTDKKILHTLEIIS 5322
Query: 3081 TRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG----------------PVWV 3124
+ G Y SNA G A S L V GP P P V
Sbjct: 5323 VTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPKKV 5382
Query: 3125 KVGKAVTLECVSAGEPRSSARWTRISSTPAKL----EQRTYGLMDS---HAVLQISSAKP 3177
K G ++T G P + W R + L + Y + S H+++ + +
Sbjct: 5383 KKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGR- 5441
Query: 3178 SDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE 3218
GTY C+A NA G A + G P+V+ +E
Sbjct: 5442 QHQGTYTCIASNAAGQA------LCSASLHVSGLPKVEEQE 5476
Score = 76.6 bits (187), Expect = 5e-13
Identities = 136/595 (22%), Positives = 203/595 (34%), Gaps = 147/595 (24%)
Query: 3022 PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH-----ISPNGSII 3076
P+ S + Q G +C++ A + W EL D H + +
Sbjct: 4898 PMFSHTFGDTEAQVGDALRLECVVAS-KADVRARWLKDGVELTDGRHHHIDQLGDGTCSL 4956
Query: 3077 TIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVS 3136
I G ++ G Y C SN +G + V G + + E S
Sbjct: 4957 LITGLDRADAGCYTCQVSNKFGQVTHSACVVVSGSESEA-----------------ESSS 4999
Query: 3137 AGE-----PRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTY------VC 3185
GE R++ R R+ T + E L S +P+D TY +C
Sbjct: 5000 GGELDDAFRRAARRLHRLFRTKSPAEVSDEELFLSADEGPAEPEEPADWQTYREDEHFIC 5059
Query: 3186 LAQNALGTAQ--------------------------KQVEVIVDTGAMAP---------- 3209
+ AL A+ ++VE+ + AP
Sbjct: 5060 IRFEALTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSL 5119
Query: 3210 ----GAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPW-------QHRL 3258
AP E V+ G+ + C TG P P++ W K L + +
Sbjct: 5120 LTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQ 5179
Query: 3259 EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVE--SPPYAT-------------- 3302
G LII V D G Y C A + G + L V+ S Y T
Sbjct: 5180 GGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQ 5239
Query: 3303 -------------TVPEHASVQAGETVQLQCLAHGTPPLTFQ------------WSRVGS 3337
T E Q E ++ +A GT FQ W + G
Sbjct: 5240 GYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQ 5299
Query: 3338 SLPGRATAR---NELLH---FERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP--PGSL 3389
L A R ++LH EDSG+Y ++N +G+A + A+LLV+GP P
Sbjct: 5300 PLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEK 5359
Query: 3390 PATSIPAGSTP---TVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEG--------G 3438
PA+ + P + TP+ K G+S+ F V + W +E G
Sbjct: 5360 PASDVHEQLVPPRMLERFTPKKVKK--GSSITFSVKVEGRPVPTVHWLREEAERGVLWIG 5417
Query: 3439 QLPPGHSV----QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSV 3489
PG++V Q L + ++ + QGTY C A G+A SA L + LP V
Sbjct: 5418 PDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLPKV 5472
Score = 69.3 bits (168), Expect = 8e-11
Identities = 50/177 (28%), Positives = 76/177 (42%), Gaps = 17/177 (9%)
Query: 1970 GRTVRLYCRAAGVPSATITWRKEGGSL---PPQARSERTD-IATLLIPAITTADAGFYLC 2025
G TV+L CR G P I+W K+G ++ P E D L++ ++T D+G Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWY 2085
A S AG +++V P V +SP V EG+ C + G+ + Q+ WY
Sbjct: 6088 FAASAAGNCSTLGKILV----QVPPRFVNKVRASPFV-EGEDAQFTCTIEGAPYPQIRWY 6142
Query: 2086 RRGGSLPPHTQVHGSR--------LRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
+ G L + L + S D G Y C + N G AS + +
Sbjct: 6143 KDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 67.0 bits (162), Expect = 4e-10
Identities = 50/177 (28%), Positives = 76/177 (42%), Gaps = 18/177 (10%)
Query: 3499 TVVVGHAVEFECLALGDPKPQVTWSKVG-------GHLRPGIVQSGGVVRIAHVELADAG 3551
T +G V+ C G PKP ++W K G H+ + + + D+G
Sbjct: 6024 TAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083
Query: 3552 QYRCTATNAAGTTQSHVLLLVQALPQ-ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSK 3610
QY C A +AAG + +LVQ P+ ++ + G A F C G P P I W K
Sbjct: 6084 QYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYK 6143
Query: 3611 LDGSL---------PPDSRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
DG+L + R +L++ + +D G Y C NR G +A A L++
Sbjct: 6144 -DGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 66.6 bits (161), Expect = 5e-10
Identities = 56/210 (26%), Positives = 86/210 (40%), Gaps = 29/210 (13%)
Query: 3291 IILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL---PGRATARN 3347
+ L V PP + + GETV+L C GTP W + G ++ P +
Sbjct: 6006 LALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIED 6065
Query: 3348 E----LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQ 3403
L + DSG+Y C + G+ ++LVQ PP + V+
Sbjct: 6066 PDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFV----------NKVR 6115
Query: 3404 VTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQD--------GVLRIQN 3455
+P +E G +F C + Q+RW+K+G L G+ Q VL I+
Sbjct: 6116 ASPFVE----GEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRA 6171
Query: 3456 LDQSCQGTYICQAHGPWGKAQASAQLVIQA 3485
+ G Y C+ G A+ASA+L IQ+
Sbjct: 6172 ASKEDLGLYECELVNRLGSARASAELRIQS 6201
Score = 63.5 bits (153), Expect = 4e-09
Identities = 71/276 (25%), Positives = 109/276 (39%), Gaps = 46/276 (16%)
Query: 2453 TLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQ 2512
++DLN V G A W +R S+ R LLQ A ++ SS +
Sbjct: 5955 SIDLNDQVEGDDRAFEVWQEREDSV---------RKYLLQARTA--------IIKSSWVK 5997
Query: 2513 EASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGG 2572
E + IQQRL+ + + + +A L G T+ L C V I+WYK G
Sbjct: 5998 E---ICGIQQRLALPVWRPPDFEEELADCTAEL--GETVKLACRVTGTPKPVISWYKDGK 6052
Query: 2573 SLP-SRHQIV------GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHV 2625
++ H I+ L + +T DSG+Y+C ++ AG+ T + +Q
Sbjct: 6053 AVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ------- 6105
Query: 2626 PSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP--SRHQTHGSH--- 2680
V P + + VEG+ C + P I WYK G L ++ QT
Sbjct: 6106 --VPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSG 6163
Query: 2681 ---LRLHQMSVADSGEYVCRANNNIDALEASIVISV 2713
L + S D G Y C N + + AS + +
Sbjct: 6164 LLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 61.2 bits (147), Expect = 2e-08
Identities = 82/357 (22%), Positives = 122/357 (34%), Gaps = 85/357 (23%)
Query: 3385 PPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG- 3443
PP LP+ + + + P Q + G V F C V +RWFK+G L
Sbjct: 5112 PPEPLPSL-LTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDD 5170
Query: 3444 ----HSVQDG--VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQA------------ 3485
+ Q G L I + + G Y C A G + A+L +
Sbjct: 5171 HYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADAT 5230
Query: 3486 ----------------------------LPSVLINIRTSVQTVVVGHAVEFECLALGDPK 3517
LP V+ +R +Q +F+ G P
Sbjct: 5231 ESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEELR-DLQVAPGTRLAKFQLKVKGYPA 5289
Query: 3518 PQVTWSKVG------GHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLL 3571
P++ W K G H+R + + I V D+GQY +NA G S LL
Sbjct: 5290 PRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLL 5349
Query: 3572 VQALP------------QISMPQEV------RVPAGSAAVFPCIASGYPTPDISWSKLDG 3613
V+ Q+ P+ + +V GS+ F G P P + W + +
Sbjct: 5350 VRGPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEA 5409
Query: 3614 S-----LPPD-------SRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
+ PD S + + L+L V Q GTY C A+N G+ A L V
Sbjct: 5410 ERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHV 5466
Score = 58.9 bits (141), Expect = 1e-07
Identities = 48/180 (26%), Positives = 75/180 (41%), Gaps = 17/180 (9%)
Query: 3410 TKSIGASVEFHCAVPSDRGTQLRWFKEGG--QLPPGHSV---QDG--VLRIQNLDQSCQG 3462
T +G +V+ C V + W+K+G Q+ P H + DG L + +L G
Sbjct: 6024 TAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083
Query: 3463 TYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTW 3522
Y+C A G ++++Q P + +R S V G +F C G P PQ+ W
Sbjct: 6084 QYMCFAASAAGNCSTLGKILVQVPPRFVNKVRAS--PFVEGEDAQFTCTIEGAPYPQIRW 6141
Query: 3523 SKVGGHLRPGIV-------QSGGVVRIAHV-ELADAGQYRCTATNAAGTTQSHVLLLVQA 3574
K G L G +SG +V + D G Y C N G+ ++ L +Q+
Sbjct: 6142 YKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQS 6201
Score = 58.2 bits (139), Expect = 2e-07
Identities = 47/165 (28%), Positives = 68/165 (41%), Gaps = 21/165 (12%)
Query: 2166 GQTLDLNCVVPGQAHAQVTWHKRGGSLPAR------HQTHGSL-LRLHQVTPADSGEYVC 2218
G+T+ L C V G ++W+K G ++ GS L L +T DSG+Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087
Query: 2219 HVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTW 2278
+G S L I V P + VR +S EG+ +C + G + Q+ W
Sbjct: 6088 FAASAAG--NCSTLGKILVQVPPRFVNKVR----ASPFVEGEDAQFTCTIEGAPYPQIRW 6141
Query: 2279 YKRGGSLPARHQVRGSR--------LYIFQASPADAGQYVCRASN 2315
YK G L ++ + L I AS D G Y C N
Sbjct: 6142 YKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVN 6186
Score = 57.0 bits (136), Expect = 4e-07
Identities = 83/337 (24%), Positives = 117/337 (34%), Gaps = 77/337 (22%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSG-----TQQRHQGSELHFPSVQPSDAG 1742
V G S C V+G P W + DG+ + + + G +L +V P+D G
Sbjct: 5137 VQDGYPVSFDCVVTGQPMPSVRWFK-DGKLLEEDDHYMINEDQQGGHQLIITAVVPADMG 5195
Query: 1743 VYICTCRNLHQSNTSRAELLV-------------TEAPS--------------------- 1768
VY C N ++++AEL V TE+ S
Sbjct: 5196 VYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTD 5255
Query: 1769 -KPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN----- 1822
+ VEE R V PG + PA L W + +G+ T +
Sbjct: 5256 EGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFK--DGQPLTASAHIRMTDKK 5313
Query: 1823 --GILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA-SGTLSAPVVSIH----PPQL 1875
L I +V D+G Y SN +A L V+ P +H PP++
Sbjct: 5314 ILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRM 5373
Query: 1876 -------TVQPGQLAEFRCSATGSPTPTLEW-------------TGGPGGQLPAKAQIHG 1915
V+ G F G P PT+ W PG + + AQ H
Sbjct: 5374 LERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHS 5433
Query: 1916 GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG 1952
L L V Q Y C A ++AGQ + A LHV G
Sbjct: 5434 --LVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSG 5468
Score = 57.0 bits (136), Expect = 4e-07
Identities = 69/285 (24%), Positives = 108/285 (37%), Gaps = 45/285 (15%)
Query: 2261 TLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEAS 2320
++DL+ V G A W +R S+ R Y+ QA A +++S
Sbjct: 5955 SIDLNDQVEGDDRAFEVWQEREDSV---------RKYLLQARTAI-----------IKSS 5994
Query: 2321 ITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGS 2380
+ G Q LA P E + G+T+ L C V G ++W+K G +
Sbjct: 5995 WVKEICGIQ-QRLALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKA 6053
Query: 2381 LPVR------HQTHGSL-LRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPAL 2433
+ V GS L L + DSG+Y+C AS G + +
Sbjct: 6054 VQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC--------FAASAAGNCSTLGKI-LV 6104
Query: 2434 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH-----GSRL 2488
V P + +S EG+ C + G + Q+ W+K G L ++ S L
Sbjct: 6105 QVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL 6164
Query: 2489 RLLQVTPA---DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQ 2530
+L + A D G Y C +V G+ AS + IQ + + Q
Sbjct: 6165 LVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPMLQAQEQ 6209
Score = 56.2 bits (134), Expect = 7e-07
Identities = 48/206 (23%), Positives = 83/206 (40%), Gaps = 29/206 (14%)
Query: 2050 PPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL---PPHTQVH----GSRL 2102
PP + E + + G+T+ L C V G+ ++WY+ G ++ P H + L
Sbjct: 6013 PPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCAL 6072
Query: 2103 RLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSH 2162
L ++ DSG+Y+C + +G S +L P +R P
Sbjct: 6073 ILDSLTGVDSGQYMCFAASAAG--NCSTLGKIL--------VQVPPRFVNKVRASP---- 6118
Query: 2163 VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA--RHQTHGS------LLRLHQVTPADSG 2214
EG+ C + G + Q+ W+K G L + QT +L + + D G
Sbjct: 6119 FVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLG 6178
Query: 2215 EYVCHVVGTSGPLEASVLVTIEASVI 2240
Y C +V G AS + I++ ++
Sbjct: 6179 LYECELVNRLGSARASAELRIQSPML 6204
Score = 56.2 bits (134), Expect = 7e-07
Identities = 54/189 (28%), Positives = 81/189 (42%), Gaps = 21/189 (11%)
Query: 1876 TVQPGQLAEFRCSATGSPTPTLEW-TGGPGGQL-PAKAQIH----GGILRLPAVEPTDQA 1929
T + G+ + C TG+P P + W G Q+ P I L L ++ D
Sbjct: 6024 TAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083
Query: 1930 QYLCRAHSSAG--QQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI 1987
QY+C A S+AG + + ++ V +V+ SP G + C G P I
Sbjct: 6084 QYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASP----FVEGEDAQFTCTIEGAPYPQI 6139
Query: 1988 TWRKEGGSLPP----QARSE-RTDIATLLIPAITTADAGFYLCVATSPAGTAQA----RI 2038
W K+G L Q SE R+ + L+I A + D G Y C + G+A+A RI
Sbjct: 6140 RWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Query: 2039 QVVVLSASD 2047
Q +L A +
Sbjct: 6200 QSPMLQAQE 6208
Score = 54.3 bits (129), Expect = 3e-06
Identities = 51/203 (25%), Positives = 83/203 (40%), Gaps = 35/203 (17%)
Query: 2630 PPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSR------HQTHGS-HLR 2682
P E + T G+T+ L C V P+ +I+WYK G ++ GS L
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 2683 LHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGS---SMPIRIESS--SSH 2737
L ++ DSG+Y+C A + +AG+ S G +P R + +S
Sbjct: 6074 LDSLTGVDSGQYMCFA---------------ASAAGNCSTLGKILVQVPPRFVNKVRASP 6118
Query: 2738 VAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSR--------LRLHHVSPADSG 2789
EGE C + G + Q+ W+K G L + ++ + L + S D G
Sbjct: 6119 FVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLG 6178
Query: 2790 EYVCRVMGSSGPLEASVLVTIEA 2812
Y C ++ G AS + I++
Sbjct: 6179 LYECELVNRLGSARASAELRIQS 6201
Score = 53.1 bits (126), Expect = 6e-06
Identities = 82/347 (23%), Positives = 124/347 (35%), Gaps = 44/347 (12%)
Query: 1656 GYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDG 1715
GY+ + +G + + Q P VVE + P + +V G P YW + DG
Sbjct: 5240 GYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFK-DG 5298
Query: 1716 RPVPSGTQQRHQGSE----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLV--TEAPSK 1769
+P+ + R + L SV D+G Y N + S A LLV + P +
Sbjct: 5299 QPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEE 5358
Query: 1770 PITVTVEEQ----------RSQSVRPGADVTFICTAKSKSPAYTLVWTR--LHNGKL--- 1814
V EQ + V+ G+ +TF + + P T+ W R G L
Sbjct: 5359 KPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGR-PVPTVHWLREEAERGVLWIG 5417
Query: 1815 ------PTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVV 1868
+ L + +V GTY C SN +A+LHV P V
Sbjct: 5418 PDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVS-----GLPKV 5472
Query: 1869 SIHPPQLTVQPGQLAEF------RCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPA 1922
Q V+ ++ F SA G T + GG + P A+ G L L
Sbjct: 5473 E---EQEKVKEALISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAAKEALGHLSLAE 5529
Query: 1923 VEPTDQAQYL-CRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVH 1968
V + Q L + ++ +A L V GG +P + H
Sbjct: 5530 VGTEEFLQKLTSQITEMVSAKITQAKLQVPGGDSDEDSKTPSASPRH 5576
Score = 51.6 bits (122), Expect = 2e-05
Identities = 47/196 (23%), Positives = 76/196 (38%), Gaps = 24/196 (12%)
Query: 2245 PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPA-RHQV------RGSRLY 2297
P E + T G+T+ L+C V G ++WYK G ++ H + L
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 2298 IFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQT 2357
+ + D+GQY+C A++ T+ Q P +R P EG+
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ-----VPPRFVNKVRASP----FVEGED 6124
Query: 2358 LDLNCVVPGQSHAQVTWHKRGGSLPV--RHQTHGS------LLRLYQASPADSGEYVCRV 2409
C + G + Q+ W+K G L + QT +L + AS D G Y C +
Sbjct: 6125 AQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECEL 6184
Query: 2410 LGSSVPLEASVLVTIE 2425
+ AS + I+
Sbjct: 6185 VNRLGSARASAELRIQ 6200
Score = 50.8 bits (120), Expect = 3e-05
Identities = 68/288 (23%), Positives = 111/288 (38%), Gaps = 44/288 (15%)
Query: 2941 TLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE 3000
++DLN V G A W +R S+ + + Q R ++ + E +C G +
Sbjct: 5955 SIDLNDQVEGDDRAFEVWQEREDSV----RKYLLQARTAIIKSSWVKE-IC------GIQ 6003
Query: 3001 QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN 3060
Q + V PP + T + G+ C + P+ +K
Sbjct: 6004 QRLALPVWRPPD-----------FEEELADCTAELGETVKLACRVTGTPKPVISWYKDGK 6052
Query: 3061 QELEDNVHI---SPNGSIITIVGTRPS-NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV 3116
D HI P+GS I+ + + G Y C A++A G ++ + V PP
Sbjct: 6053 AVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVN 6112
Query: 3117 LPEGPVWVKVGKAVTLECVSAGEPRSSARWTR---ISSTPAK---LEQRTYGLMDSHAVL 3170
+V+ G+ C G P RW + + +T K L + GL+ VL
Sbjct: 6113 KVRASPFVE-GEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLL----VL 6167
Query: 3171 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE 3218
I +A D G Y C N LG+A+ E+ + +P +QA+E
Sbjct: 6168 VIRAASKEDLGLYECELVNRLGSARASAELRIQ-------SPMLQAQE 6208
Score = 50.8 bits (120), Expect = 3e-05
Identities = 49/194 (25%), Positives = 73/194 (37%), Gaps = 31/194 (15%)
Query: 2823 PGGAPPIRIEPSSSRVAE-GQTLDLKCVVPGQAHAQVTWHKRGGNL---PARHQVHGP-- 2876
P PP E + AE G+T+ L C V G ++W+K G + P + P
Sbjct: 6009 PVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDG 6068
Query: 2877 --LLRLNQVSPADSGEYSCQVTGSSGTLEA--SVLVTIEPSSPGPIPAPGLAQPIYIEAS 2932
L L+ ++ DSG+Y C ++G +LV + P + A
Sbjct: 6069 SCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRA------------ 6116
Query: 2933 SSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA--RHQTHGSQ------LRLHLVSPA 2984
S EG+ C + G + Q+ WYK G L + QT L + S
Sbjct: 6117 -SPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKE 6175
Query: 2985 DSGEYVCRAASGPG 2998
D G Y C + G
Sbjct: 6176 DLGLYECELVNRLG 6189
Score = 49.7 bits (117), Expect = 6e-05
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 1/84 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P+ +T P+ + S G+ T +C +G PTP ++W + + + R + +G L
Sbjct: 10 PRFLTRPKAFV-VSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLT 68
Query: 466 IRDVKESDQGAYTCEAMNARGMVF 489
I D+ D G Y C A NA G F
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAF 92
Score = 46.6 bits (109), Expect = 5e-04
Identities = 31/107 (28%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 389 DEESDCPDRSDEFGCMPPQVV---TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWG 445
DE + P +PP+++ TP + +G ++TF+ G P P ++W
Sbjct: 5354 DEPEEKPASDVHEQLVPPRMLERFTPKK----VKKGSSITFSVKVEGRPVPTVHWLREEA 5409
Query: 446 HI------PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
P P TV S + +L++ DV QG YTC A NA G
Sbjct: 5410 ERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAG 5456
Score = 44.3 bits (103), Expect = 0.003
Identities = 30/100 (30%), Positives = 40/100 (40%), Gaps = 10/100 (10%)
Query: 389 DEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI- 447
D E+ C +++ F P SI+ G TF C G P P ++W + +
Sbjct: 100 DAEAACAEQAPHFLLRPT--------SIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLG 151
Query: 448 -PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
P PRV V G L IR + D G Y A N G
Sbjct: 152 EPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLG 191
Score = 43.1 bits (100), Expect = 0.006
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
P V P +S+QA G T T C + PT + W + ++ R +G L
Sbjct: 3888 PQPVFREPLQSLQAEEGSTATLQC-ELSEPTATVVWSKGGLQLQANGRREPRLQGCTAEL 3946
Query: 465 IIRDVKESDQGAYTC 479
+++D++ D G YTC
Sbjct: 3947 VLQDLQREDTGEYTC 3961
Score = 42.4 bits (98), Expect = 0.010
Identities = 27/85 (31%), Positives = 37/85 (43%), Gaps = 3/85 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG- 462
+PP+ V R S G+ FTC G P P I W + + + + SE G
Sbjct: 6106 VPPRFVNKVRAS-PFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL 6164
Query: 463 -TLIIRDVKESDQGAYTCEAMNARG 486
L+IR + D G Y CE +N G
Sbjct: 6165 LVLVIRAASKEDLGLYECELVNRLG 6189
Score = 41.6 bits (96), Expect = 0.018
Identities = 28/93 (30%), Positives = 35/93 (37%), Gaps = 7/93 (7%)
Query: 3582 QEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENN-------MLMLPSVRPQ 3634
Q V G F C+ +G P P + W K L D N L++ +V P
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192
Query: 3635 DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFT 3667
D G Y C A N G A L+V Y T
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRVDLTSTDYDT 5225
Score = 40.4 bits (93), Expect = 0.039
Identities = 45/183 (24%), Positives = 73/183 (39%), Gaps = 23/183 (12%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQ----QRHQGS-ELHFPSVQPSDAGVYI 1745
G + L C+V+G+P W + DG+ V + GS L S+ D+G Y+
Sbjct: 6028 GETVKLACRVTGTPKPVISWYK-DGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
C + + ++ ++LV P V + R+ G D F CT + +P +
Sbjct: 6087 CFAASAAGNCSTLGKILVQVPPR-----FVNKVRASPFVEGEDAQFTCTIEG-APYPQIR 6140
Query: 1806 WTRLHNGKLPTRAMDFNG---------ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLH 1856
W + +G L T F +L IR D G Y C N + +A L
Sbjct: 6141 WYK--DGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198
Query: 1857 VQA 1859
+Q+
Sbjct: 6199 IQS 6201
Score = 39.3 bits (90), Expect = 0.087
Identities = 25/95 (26%), Positives = 41/95 (43%), Gaps = 2/95 (2%)
Query: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVK 470
P +QA G + T +C T + W + + S +V V + G L+++
Sbjct: 1631 PAHREVQAEAGASATLSCEVAQAQTEV-TWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAG 1689
Query: 471 ESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPC 505
++D G Y+CEA R + F + LE PC
Sbjct: 1690 QADAGEYSCEAGGQR-LSFRLHVAELEPQISERPC 1723
Score = 39.3 bits (90), Expect = 0.087
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 1/70 (1%)
Query: 418 ASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHP-RVTVTSEGGRGTLIIRDVKESDQGA 476
A G+TV C G P P+I+W + + P + + G LI+ + D G
Sbjct: 6025 AELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQ 6084
Query: 477 YTCEAMNARG 486
Y C A +A G
Sbjct: 6085 YMCFAASAAG 6094
Score = 38.9 bits (89), Expect = 0.11
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
+QA G + T +C T ++ W + + S +V V ++G R L+++ ++D G
Sbjct: 992 VQAEAGASATLSCEVAQAQTEVM-WYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAG 1050
Query: 476 AYTCEAMNAR 485
Y+CEA R
Sbjct: 1051 DYSCEARGQR 1060
Score = 38.1 bits (87), Expect = 0.19
Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHI--PSHPRVTVTSEGGRGTLIIRDVKESDQGAYT 478
G V+F CV G P P + W + + H + +GG LII V +D G Y
Sbjct: 5140 GYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGH-QLIITAVVPADMGVYR 5198
Query: 479 CEAMNARGM 487
C A N+ G+
Sbjct: 5199 CLAENSMGV 5207
Score = 37.0 bits (84), Expect = 0.43
Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 6/95 (6%)
Query: 397 RSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVT 456
R++ PP T + + G+ +C G P P W+ + G + + R V
Sbjct: 231 RAEGAPASPPSTGT---RTCTVTEGKHARLSCYVTGEPKPETVWKKD-GQLVTEGRRHVV 286
Query: 457 SEGGRGTLIIRDV--KESDQGAYTCEAMNARGMVF 489
E + +++ + K+SD+G YTC A N G +
Sbjct: 287 YEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTY 321
Score = 37.0 bits (84), Expect = 0.43
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 413 RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKES 472
R +QA G + T +C T + W + + S +V + + G L+++ ++
Sbjct: 897 RRKLQAEAGASATLSCEVAQAQTEV-TWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQA 955
Query: 473 DQGAYTCEAMNAR 485
D G Y+CEA R
Sbjct: 956 DAGEYSCEAGGQR 968
Score = 37.0 bits (84), Expect = 0.43
Identities = 19/70 (27%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
+QA G T +C + P + W + + S +V + +G L+++ V ++D G
Sbjct: 1176 VQAEAGTTAMLSC-EVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAG 1234
Query: 476 AYTCEAMNAR 485
Y+CEA R
Sbjct: 1235 EYSCEAGGQR 1244
Score = 36.6 bits (83), Expect = 0.56
Identities = 18/75 (24%), Positives = 36/75 (48%), Gaps = 1/75 (1%)
Query: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVK 470
P +QA G + T +C T + W + + S +V + + G L++++
Sbjct: 1539 PASREVQAEAGTSATLSCEVAQAQTEV-TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAG 1597
Query: 471 ESDQGAYTCEAMNAR 485
++D G Y+C+A + R
Sbjct: 1598 QADAGEYSCKAGDQR 1612
Score = 36.6 bits (83), Expect = 0.56
Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 1/75 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P + P E + G+ V C TP+ +W + I + V EG L+
Sbjct: 2826 PAAIIKPLEDQWVAPGEDVELRCELSRAGTPV-HWLKDRKAIRKSQKYDVVCEGTMAMLV 2884
Query: 466 IRDVKESDQGAYTCE 480
IR D G YTCE
Sbjct: 2885 IRGASLKDAGEYTCE 2899
Score = 35.0 bits (79), Expect = 1.6
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 3/76 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PPQ P ES Q + G+ V+ + +I W I R V S+G +
Sbjct: 4623 VPPQPSAP--ESRQVAAGEDVSLELEVVAEAGEVI-WHKGMERIQPGGRFEVVSQGRQQM 4679
Query: 464 LIIRDVKESDQGAYTC 479
L+I+ DQG Y C
Sbjct: 4680 LVIKGFTAEDQGEYHC 4695
Score = 34.7 bits (78), Expect = 2.1
Identities = 17/70 (24%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
++ G + T +C T + W + + S +V + + G L+++ ++D G
Sbjct: 1268 VRTEAGASATLSCEVAQAQTEV-TWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAG 1326
Query: 476 AYTCEAMNAR 485
YTCEA R
Sbjct: 1327 EYTCEAGGQR 1336
Score = 34.7 bits (78), Expect = 2.1
Identities = 26/108 (24%), Positives = 46/108 (42%), Gaps = 14/108 (12%)
Query: 3296 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLP----------GRATA 3345
E P ++ T + Q G+ ++L+C+ + +W + G L G T
Sbjct: 4896 EGPMFSHTFGD-TEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTC 4954
Query: 3346 RNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATS 3393
+ +RA D+G Y C+V+NK G A ++V G ++S
Sbjct: 4955 SLLITGLDRA---DAGCYTCQVSNKFGQVTHSACVVVSGSESEAESSS 4999
Score = 33.9 bits (76), Expect = 3.7
Identities = 18/70 (25%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
+QA G T +C T + W + + S +V + + G L+++ ++D G
Sbjct: 1360 VQAEAGAIATLSCEVAQAQTEV-TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTG 1418
Query: 476 AYTCEAMNAR 485
Y+CEA R
Sbjct: 1419 EYSCEAGGQR 1428
Score = 33.5 bits (75), Expect = 4.8
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
G T F CV + VP ++W N + + RV +++EG R TL I D G
Sbjct: 435 GDTAMF-CVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVG 488
Score = 33.1 bits (74), Expect = 6.2
Identities = 14/48 (29%), Positives = 22/48 (45%)
Query: 438 INWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNAR 485
+ W + + P+ V + GR L++RDV D G Y C + R
Sbjct: 737 VTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGR 784
>gi|148833506 obscurin, cytoskeletal calmodulin and titin-interacting
RhoGEF isoform b [Homo sapiens]
Length = 7968
Score = 260 bits (664), Expect = 2e-68
Identities = 473/1841 (25%), Positives = 693/1841 (37%), Gaps = 356/1841 (19%)
Query: 1984 SATITWRKEGGSLPPQARSERTDIA---TLLIPAITTADAGFYLCVATSPAGTAQARIQ- 2039
+A +TW K+G +L P + E A LL+ + DAG Y CV+ Q +Q
Sbjct: 734 AAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQG 793
Query: 2040 VVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVH- 2098
+ D + V + P+ E +T AH V WY+ G L +
Sbjct: 794 LARFLHKDMAGSCVDAVAGGPAQFECET--------SEAHVHVHWYKDGMELGHSGERFL 845
Query: 2099 ----GSRLRL--PQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTR 2152
G+R RL V+ D G Y CRV G + + VS + + R
Sbjct: 846 QEDVGTRHRLVAATVTRQDEGTYSCRV--GEDSVDFRLRVS-----EPKVVFAKEQLARR 898
Query: 2153 PIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARH----QTHGSLLRL--H 2206
++ E G + L+C V QA +VTW+K G L + + G RL
Sbjct: 899 KLQAE-------AGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQ 950
Query: 2207 QVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSC 2266
Q AD+GEY C G V E V+ ++ S G + LSC
Sbjct: 951 QAGQADAGEYSCEAGGQRLSFHLDVK---EPKVV---FAKDQVAHSEVQAEAGASATLSC 1004
Query: 2267 VVAGQAHAQVTWYKRG----GSLPARHQVRG--SRLYIFQASPADAGQYVCRASNGMEAS 2320
VA QA +V WYK G SL + +G RL + QA DAG Y C A G S
Sbjct: 1005 EVA-QAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA-RGQRVS 1062
Query: 2321 ITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG-- 2378
+ +T + Q + E Q G + L+C V Q+ +VTW+K G
Sbjct: 1063 FRLHITEPK-----MMFAKEQSVHNE---VQAEAGASAMLSCEV-AQAQTEVTWYKDGKK 1113
Query: 2379 --GSLPVRHQTHGSLLRLY--QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALG 2434
S V + G RL QA AD+GEY C G V + EP G
Sbjct: 1114 LSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHI---TEPK------G 1164
Query: 2435 VTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPA----RHQVHGSRLRL 2490
V + + Q G T L+C VA Q +VTW+K G L + R +V G RL
Sbjct: 1165 VFAKEQSVHNEVQAEAGTTAMLSCEVA-QPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRL 1223
Query: 2491 L--QVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANG 2548
+ QV AD+GEY C + G + + L + + + Q V VR E+ G
Sbjct: 1224 VVQQVGKADAGEYSCE---AGGQRVSFQLHITEPKAVFAKEQLVHNEVRTEA-------G 1273
Query: 2549 HTLDLNCLVASQAPHTITWYKRGGSLPSRHQI------VGSRLRIPQVTPADSGEYVCHV 2602
+ L+C VA QA +TWYK G L S ++ +L + Q AD+GEY C
Sbjct: 1274 ASATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCE- 1331
Query: 2603 SNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIIT 2662
AG + S + + S +V ++ G L+C VA Q Q +T
Sbjct: 1332 ---AGGQRLSFHLDV-----SEPKAVFAKEQLAHRKVQAEAGAIATLSCEVA-QAQTEVT 1382
Query: 2663 WYKRGGSLPS----RHQTHGSHLRL--HQMSVADSGEYVCRANN-----NIDALEASIVI 2711
WYK G L S R + G RL Q AD+GEY C A ++D E +V
Sbjct: 1383 WYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEAGGQRLSFSLDVAEPKVVF 1442
Query: 2712 SVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHH 2771
+ P+ E + G + L+C V QA +V W+K G L
Sbjct: 1443 A------------KEQPVHREVQAQ---AGASTTLSCEV-AQAQTEVMWYKDGKKLSFSS 1486
Query: 2772 QTR------GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2825
+ R RL + A +GEY C GS S +HV P
Sbjct: 1487 KVRMEAVGCTRRLVVQQAGQAVAGEYSCEA-GSQ-------------RLSFHLHVAEP-K 1531
Query: 2826 APPIRIEPSSSRV--AEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH----GPLLR 2879
A + +P+S V G + L C V QA +VTW+K G L + +V G R
Sbjct: 1532 AVFAKEQPASREVQAEAGTSATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRR 1590
Query: 2880 L--NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
L + AD+GEYSC+ + V + P + A QP + E +
Sbjct: 1591 LVVQEAGQADAGEYSCKAGDQRLSFHLHV------AEPKVVFAK--EQPAHREVQAE--- 1639
Query: 2938 EGQTLDLNCVVPGQAHAQVTWYKRGGSLPA----RHQTHGSQLRL--HLVSPADSGEYVC 2991
G + L+C V QA +VTWYK G L + R + G RL AD+GEY C
Sbjct: 1640 AGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSC 1698
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDP---PSSTVQQGQDASFKCLIHDG 3048
A Q SF + V E P IS P V++ +D +
Sbjct: 1699 EAGG-----QRLSFRLHVAELE--------PQISERPCRREPLVVKEHEDIILTATLATP 1745
Query: 3049 AAPISLEWKTRNQELEDNVHI----------SPNGSIITIVGTRPSNHGTYRC-VASNAY 3097
+A ++ W L+D V I + +T+ G + + Y C V +
Sbjct: 1746 SA-ATVTW------LKDGVEIRRSKRHETASQGDTHTLTVHGAQVLDSAIYSCRVGAEGQ 1798
Query: 3098 GVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLE 3157
V ++ + PV ++G VTL C + P + R +T ++
Sbjct: 1799 DFPVQVEEVAAKFCRLLE-----PVCGELGGTVTLACELS--PACAEVVWRCGNTQLRVG 1851
Query: 3158 QRTYGLMDSHA-VLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQA 3216
+R + + L + + DAG YVC +++ +AQ V V P + +
Sbjct: 1852 KRFQMVAEGPVRSLTVLGLRAEDAGEYVCESRDDHTSAQLTVSV--------PRVVKFMS 1903
Query: 3217 EEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRL------EGDTLIIPRVAQ 3270
+ + E G AT +C + S + W + + L + +L I +
Sbjct: 1904 GLSTVVAEEGGEATFQCVVSPSDVAVV-WFRDGALLQPSEKFAISQSGASHSLTISDLVL 1962
Query: 3271 QDSGQYICNATSPAGHA-----EATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGT 3325
+D+GQ A + A EA ++ + P TV E +SV T++++ L
Sbjct: 1963 EDAGQITVEAEGASSSAALRVREAPVLFKKKLEP--QTVEERSSV----TLEVE-LTRPW 2015
Query: 3326 PPLTFQWSRVGSSLPGRATARNELLHFERAAPE---------DSGRYRCRVTNKVGSAEA 3376
P L +W+R ++L A +N +H E A D G + C + A+
Sbjct: 2016 PEL--RWTRNATAL---APGKNVEIHAEGARHRLVLHNVGFADRGFFGCETPDDKTQAKL 2070
Query: 3377 FAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKE 3436
++ L A T T++V QL + S W ++
Sbjct: 2071 TVEMRQVRLVRGLQAVEAREQGTATMEV--QLSHADVDGS----------------WTRD 2112
Query: 3437 G---GQLPPGHSVQDG---VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVL 3490
G Q P H G L + L G + +A G SA+LV+ LP
Sbjct: 2113 GLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSGLMVFKAEG----VHTSARLVVTELP--- 2165
Query: 3491 INIRTSVQTVVV--GHAVEFECLALGDPKPQVTWSKVGGHLRPG---IVQSGGVVR---I 3542
++ +Q VV V EC L P V W K G LR G + + G R I
Sbjct: 2166 VSFSRPLQDVVTTEKEKVTLEC-ELSRPNVDVRWLKDGVELRAGKTMAIAAQGACRSLTI 2224
Query: 3543 AHVELADAGQYRCTATNA-------------------------------AGTTQSHVLLL 3571
E AD G Y C A +A A +S L
Sbjct: 2225 YRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDAGEIQFVAENAESRAQLR 2284
Query: 3572 VQALPQISMPQEVR---VPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE------ 3622
V+ LP +++ + +R V C S + + W K L P + E
Sbjct: 2285 VKELP-VTLVRPLRDKIAMEKHRGVLECQVS-RASAQVRWFKGSQELQPGPKYELVSDGL 2342
Query: 3623 NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERVV 3663
L++ V +D TY C A G VK A V E+ +
Sbjct: 2343 YRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQSI 2379
Score = 260 bits (664), Expect = 2e-68
Identities = 496/1972 (25%), Positives = 737/1972 (37%), Gaps = 343/1972 (17%)
Query: 1824 ILTIRNVQLSDAGTYVCT---GSNMFAMD-QGTAT-LHVQASGTLSAPVVSIHPPQLTVQ 1878
+L +R+V DAG Y C G + + QG A LH +G+ V
Sbjct: 762 VLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDMAGSCVDAVA---------- 811
Query: 1879 PGQLAEFRCSATGSPTPTLEWTG-----GPGGQLPAKAQIHGGILRLPAVEPT--DQAQY 1931
G A+F C T + W G G+ + + G RL A T D+ Y
Sbjct: 812 -GGPAQFECE-TSEAHVHVHWYKDGMELGHSGERFLQEDV-GTRHRLVAATVTRQDEGTY 868
Query: 1932 LCRAHSSAGQQVARAVLHVHGGGGPRV-----QVSPERTQVHAGRTVRLYCRAAGVPSAT 1986
CR G+ L V P+V Q++ + Q AG + L C A
Sbjct: 869 SCR----VGEDSVDFRLRV---SEPKVVFAKEQLARRKLQAEAGASATLSCEVAQA-QTE 920
Query: 1987 ITWRKEGGSLPPQAR--SERTDIA-TLLIPAITTADAGFYLCVATSPAGTAQARI-QVVV 2042
+TW K+G L ++ E T L++ ADAG Y C A + + + V
Sbjct: 921 VTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKV 980
Query: 2043 LSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRG----GSLPPHTQVH 2098
+ A D ++ S G + L+C VA A +V WY+ G SL H +
Sbjct: 981 VFAKD------QVAHSEVQAEAGASATLSCEVA-QAQTEVMWYKDGKKLSSSLKVHVEAK 1033
Query: 2099 GSRLRL--PQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRI 2156
G R RL Q D+G+Y C + S LH T + ++
Sbjct: 1034 GCRRRLVVQQAGKTDAGDYSCEARG----QRVSFR---LHITEPKMMFAKEQSVHNEVQA 1086
Query: 2157 EPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSL------LRLHQVTP 2210
E +S + L+C V QA +VTW+K G L + + + L L Q
Sbjct: 1087 EAGASAM-------LSCEV-AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGK 1138
Query: 2211 ADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAG 2270
AD+GEY C G V + + G + + G T LSC VA
Sbjct: 1139 ADAGEYSCEAGG------QRVSFHLHITEPKGVFAKEQSVHNEVQAEAGTTAMLSCEVA- 1191
Query: 2271 QAHAQVTWYKRGGSLPARHQVR------GSRLYIFQASPADAGQYVCRASNGMEASITVT 2324
Q +VTWYK G L + +VR RL + Q ADAG+Y C A G S +
Sbjct: 1192 QPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEA-GGQRVSFQLH 1250
Query: 2325 VTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRG----GS 2380
+T P ++ + + G + L+C V Q+ +VTW+K G S
Sbjct: 1251 IT--------EPKAVFAKEQLVHNEVRTEAGASATLSCEV-AQAQTEVTWYKDGKKLSSS 1301
Query: 2381 LPVRHQTHGSLLRL--YQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPT 2438
VR + G + +L QA AD+GEY C G + V EP V
Sbjct: 1302 SKVRIEAAGCMRQLVVQQAGQADAGEYTCEAGGQRLSFHLDV---SEPK------AVFAK 1352
Query: 2439 VRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH------GSRLRLLQ 2492
++ Q G L+C VA QA +VTW+K G L + +V RL + Q
Sbjct: 1353 EQLAHRKVQAEAGAIATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQ 1411
Query: 2493 VTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552
AD+GEY C + G + + L + ++ + Q V V+ ++ G +
Sbjct: 1412 ACQADTGEYSCE---AGGQRLSFSLDVAEPKVVFAKEQPVHREVQAQA-------GASTT 1461
Query: 2553 LNCLVASQAPHTITWYKRGGSL----PSRHQIVG--SRLRIPQVTPADSGEYVCHVSNGA 2606
L+C VA QA + WYK G L R + VG RL + Q A +GEY C A
Sbjct: 1462 LSCEVA-QAQTEVMWYKDGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCE----A 1516
Query: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVE-----GQTLDLNCVVARQPQAII 2661
GS+ S H+ P P E G + L+C VA Q Q +
Sbjct: 1517 GSQRLSF----------HLHVAEPKAVFAKEQPASREVQAEAGTSATLSCEVA-QAQTEV 1565
Query: 2662 TWYKRGGSLPS----RHQTHGSHLRL--HQMSVADSGEYVCRANNNIDALEASIVISVSP 2715
TWYK G L S R + G RL + AD+GEY C+A + + + P
Sbjct: 1566 TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCKAGDQRLSFHLHV---AEP 1622
Query: 2716 SAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTR- 2774
+ ++ E+ G + L+C V QA +VTW+K G L S + R
Sbjct: 1623 KVVFAKEQPAHREVQAEA-------GASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRV 1674
Query: 2775 -----GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPI 2829
RL + AD+GEY C G V +E S P
Sbjct: 1675 EAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHV-AELEPQISER----------PC 1723
Query: 2830 RIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL--PARHQVHGP----LLRLNQV 2883
R EP V E + + L + + A VTW K G + RH+ L ++
Sbjct: 1724 RREPLV--VKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETASQGDTHTLTVHGA 1781
Query: 2884 SPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLD 2943
DS YSC+V G+ G V +E + L +P+ E G T+
Sbjct: 1782 QVLDSAIYSCRV-GAEG---QDFPVQVEEVA---AKFCRLLEPVCGEL-------GGTVT 1827
Query: 2944 LNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPA-----------DSGEYVCR 2992
L C + A A+V W R G+ R G + ++ P D+GEYVC
Sbjct: 1828 LACEL-SPACAEVVW--RCGNTQLR---VGKRFQMVAEGPVRSLTVLGLRAEDAGEYVCE 1881
Query: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTV--QQGQDASFKCLIHDGAA 3050
+ A TV+VP V+ STV ++G +A+F+C++ +
Sbjct: 1882 SRD---DHTSAQLTVSVP-----------RVVKFMSGLSTVVAEEGGEATFQCVV--SPS 1925
Query: 3051 PISLEWKTRNQELE--DNVHISPNGS--IITIVGTRPSNHGTYRCVASNAYGVAQSVVNL 3106
+++ W L+ + IS +G+ +TI + G A A S L
Sbjct: 1926 DVAVVWFRDGALLQPSEKFAISQSGASHSLTISDLVLEDAGQITVEAEG----ASSSAAL 1981
Query: 3107 SVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDS 3166
V P + P V+ +VTLE V P RWTR ++ A + +
Sbjct: 1982 RVREAPVLFKKKLEPQTVEERSSVTLE-VELTRPWPELRWTRNATALAPGKNVEIHAEGA 2040
Query: 3167 HAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE---AELTV 3223
L + + +D G + C + Q ++ V + + G V+A E A + V
Sbjct: 2041 RHRLVLHNVGFADRGFFGC--ETPDDKTQAKLTVEMRQVRLVRGLQAVEAREQGTATMEV 2098
Query: 3224 EAGHT----ATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICN 3279
+ H + R PT H + +R P+ TL + + +DSG +
Sbjct: 2099 QLSHADVDGSWTRDGLRFQQGPTCHLA-VRGPM--------HTLTLSGLRPEDSGLMVFK 2149
Query: 3280 ATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQW------S 3333
A H A +++ E P + + E V L+C P + +W
Sbjct: 2150 AEGV--HTSARLVV-TELPVSFSRPLQDVVTTEKEKVTLEC-ELSRPNVDVRWLKDGVEL 2205
Query: 3334 RVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATS 3393
R G ++ A L R D G Y C A++ A + VQG +L
Sbjct: 2206 RAGKTMAIAAQGACRSLTIYRCEFADQGVYVC----DAHDAQSSASVKVQGRTYTLIYRR 2261
Query: 3394 IPAGSTPTVQVT-------PQLETKSIGA----------SVEFHCAV----PSDRGTQLR 3432
+ A +Q QL K + ++E H V S Q+R
Sbjct: 2262 VLAEDAGEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQVR 2321
Query: 3433 WFKEGGQLPPG---HSVQDGVLR---IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQAL 3486
WFK +L PG V DG+ R I ++ + TY C A G + SAQ ++
Sbjct: 2322 WFKGSQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDA----GDVKTSAQFFVEEQ 2377
Query: 3487 PSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVE 3546
++ V TV+ FEC W L ++Q+GG V +
Sbjct: 2378 SITIVRGLQDV-TVMEPAPAWFECETSIPSVRPPKWL-----LGKTVLQAGGNVGLEQEG 2431
Query: 3547 LADAGQYRCTATN-------AAGTTQSHVLLLVQALPQI-SMPQEVRVPAG-SAAVFPCI 3597
R T + G ++S L+V +P + + P E + + V C
Sbjct: 2432 TVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGRELQSVVLSCD 2491
Query: 3598 ASGYPTPDISWSKLDGSLPPDSR----LENNMLMLPSVR--PQDAGTYVCTA 3643
P + W K D L P + LE M L +R P DAG Y C A
Sbjct: 2492 FRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQA 2542
Score = 217 bits (553), Expect = 2e-55
Identities = 488/2084 (23%), Positives = 768/2084 (36%), Gaps = 371/2084 (17%)
Query: 1692 GSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRH--------QGSELHFPSVQPSDAGV 1743
G+ +L+C+VS H + R+DG V G ++ +G +H V P DAG+
Sbjct: 2662 GTLALQCEVSDPEAHVVW--RKDG--VQLGPSDKYDFLHTAGTRGLVVH--DVSPEDAGL 2715
Query: 1744 YICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYT 1803
Y C S +RA + V + + +T + ++ V G +F C +S +
Sbjct: 2716 YTCHV----GSEETRARVRVHDL---HVGIT-KRLKTMEVLEGESCSFECVLSHESASDP 2767
Query: 1804 LVWTRLHNGKLPTRAMDFNG-------ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLH 1856
+WT GK + F IL +R SDAG V + + A+L
Sbjct: 2768 AMWT--VGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGEVVFSVRGL----TSKASLI 2821
Query: 1857 VQASGTLSAPVVSIHP-PQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHG 1915
V+ P I P V PG+ E RC + + TP + W + K+Q +
Sbjct: 2822 VR-----ERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWL--KDRKAIRKSQKYD 2873
Query: 1916 -------GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGG------PRVQVSP 1962
+L + D +Y C +S + A LHV +QV
Sbjct: 2874 VVCEGTMAMLVIRGASLKDAGEYTCEVEASK----STASLHVEEKANCFTEELTNLQVEE 2929
Query: 1963 ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR-----SERTDIATLLIPAITT 2017
+ T V +T P+AT+TWRK G L +A S+ L I A+
Sbjct: 2930 KGTAVFTCKTEH--------PAATVTWRK--GLLELRASGKHQPSQEGLTLRLTISALEK 2979
Query: 2018 ADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGS 2077
AD+ Y C G AQ+R Q++V + + V EG + C ++ +
Sbjct: 2980 ADSDTYTC----DIGQAQSRAQLLV----QGRRVHIIEDLEDVDVQEGSSATFRCRISPA 3031
Query: 2078 AHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHG 2137
+ V W+ T +H + L ++ G +V + + + S T+ G
Sbjct: 3032 NYEPVHWFL------DKTPLHANELN--EIDAQPGGYHVLTLRQLA--LKDSGTIYFEAG 3081
Query: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL----- 2192
+ V E + + + EG+ L L C V W K G +L
Sbjct: 3082 DQRASAALRVTEKPSVFSRELTDATITEGEDLTLVCET-STCDIPVCWTKDGKTLRGSAR 3140
Query: 2193 -PARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIES 2251
H+ H + L + T DSG Y C G +S +V + A PVR +
Sbjct: 3141 CQLSHEGHRAQLLITGATLQDSGRYKCEAGGAC----SSSIVRVHAR-------PVRFQE 3189
Query: 2252 S--SSTVAEGQTLDLSCVVAGQAHAQVTW------YKRGGSLPARHQVRGSRLYIFQASP 2303
+ V EG L CV++ A A V W + G R + L + P
Sbjct: 3190 ALKDLEVLEGGAATLRCVLSSVA-APVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRP 3248
Query: 2304 ADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCV 2363
D+G+Y C + S T+TVT A PA +R + + EG T L C
Sbjct: 3249 QDSGRYSC-SFGDQTTSATLTVT-------ALPAQFIGKLR----NKEATEGATATLRCE 3296
Query: 2364 VPGQSHAQVTWHKRGGSLP------VRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLE 2417
+ A V W K +L +R L++ + D+ EY C V G
Sbjct: 3297 L--SKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSC-VCGEE---R 3350
Query: 2418 ASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL 2477
S +TI P +PA + ES EG T L C ++ A V W K SL
Sbjct: 3351 TSASLTIRP---MPAHFIGRLRHQES-----IEGATATLRCELS--KAAPVEWRKGRESL 3400
Query: 2478 --PARHQVHGS----RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQG 2531
RH + L++ + AD+GEY C G + S +T+ + L ++G
Sbjct: 3401 RDGDRHSLRQDGAVCELQICGLAVADAGEYSC----VCGEERTSATLTV-KALPAKFTEG 3455
Query: 2532 VAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV----GSR--L 2585
+ +E ++A L C ++ AP + W K +L + + G+R L
Sbjct: 3456 LRNEEAVEGATAMLW--------CELSKVAP--VEWRKGPENLRDGDRYILRQEGTRCEL 3505
Query: 2586 RIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQ 2645
+I + AD+GEY+C G TS +TI+ + + V + EG
Sbjct: 3506 QICGLAMADAGEYLC----VCGQERTSATLTIRALPARFIEDV--------KNQEAREGA 3553
Query: 2646 TLDLNCVVARQPQAIITWYKRGGSLPS------RHQTHGSHLRLHQMSVADSGEYVCRAN 2699
T L C + A + W K +L R L++ +++AD+GEY C
Sbjct: 3554 TAVLQCEL--NSAAPVEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCG 3611
Query: 2700 NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESS--SSHVAEGETLDLNCVVPGQAHAQ 2757
S +++V ++PI+ + EG T L C + A
Sbjct: 3612 QE----RTSAMLTV-----------RALPIKFTEGLRNEEATEGATAVLRCEL--SKMAP 3654
Query: 2758 VTWHK-----RGGSLPSHHQTRGSR--LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTI 2810
V W K R G S Q G+R L++ + D+GEY+C G S ++T+
Sbjct: 3655 VEWWKGHETLRDGDRHSLRQD-GARCELQIRGLVAEDAGEYLC----MCGKERTSAMLTV 3709
Query: 2811 EASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHK-----RGG 2865
A S + +R E ++ EG T L C + A V W K R G
Sbjct: 3710 RAMPSKFIE--------GLRNEEAT----EGDTATLWCEL--SKAAPVEWRKGHETLRDG 3755
Query: 2866 NLPARHQVHGPL-LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLA 2924
+ + Q L++ ++ D+GEYSC V G T S +T+ +PA +
Sbjct: 3756 DRHSLRQDGSRCELQIRGLAVVDAGEYSC-VCGQERT---SATLTVR-----ALPARFIE 3806
Query: 2925 QPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK-----RGGS-LPARHQTHGSQLRL 2978
+ + EG T L C + A V W K RGG R +L++
Sbjct: 3807 -----DVKNQEAREGATAVLQCEL--SKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQI 3859
Query: 2979 HLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQD 3038
H +S AD+GEY C ++ S T+TV R PV S ++G
Sbjct: 3860 HGLSVADTGEYSCVCG-----QERTSATLTV--------RAPQPVFREPLQSLQAEEGST 3906
Query: 3039 ASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN----GSIITIVGTRPSNHGTYRCVAS 3094
A+ +C + + A ++ W +L+ N P + + + + + G Y C
Sbjct: 3907 ATLQCELSEPTA--TVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCTC- 3963
Query: 3095 NAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPA 3154
G + L+V P + V G L C +S W + S
Sbjct: 3964 ---GSQATSATLTVTAAPVRFLRELQHQEVDEGGTAHL-CCELSRAGASVEWRKGSLQLF 4019
Query: 3155 KLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV 3214
+ + A L + + DAG Y C + A V V P+
Sbjct: 4020 PCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRV---------PRPKF 4070
Query: 3215 QAEEAELTVEAGHTATLRCSATGSPA-PTIHWSK----LRSPLPWQHRLEGDT--LIIPR 3267
+ L E G A L C + + + + W K L + ++ R +G T L+I +
Sbjct: 4071 KTRLQSLEQETGDIARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQ 4130
Query: 3268 VAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP--EHASVQAGETVQLQCLAHGT 3325
+ +D+G+Y C G + L V + P T V A V A E V+ C
Sbjct: 4131 LEAKDTGEYAC----VTGGQKTAASLRV-TEPEVTIVRGLVDAEVTADEDVEFSCEVSRA 4185
Query: 3326 PPLTFQWSRVGSSLPGRAT-------ARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFA 3378
QW G L R L + PED+G V+ +G+ + A
Sbjct: 4186 GATGVQWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAG----TVSFHLGNHASSA 4241
Query: 3379 QLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGG 3438
QL V+ P T+ Q S G F C + G + RW G
Sbjct: 4242 QLTVRAP-------------EVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGV 4288
Query: 3439 QLPPGH----SVQDGVLRIQNLDQ-SCQGTYICQAHGPWGKAQASAQLVIQALPSVLINI 3493
L +V+ G L + L + + + H G + AQL + A +V+ +
Sbjct: 4289 PLQANEMNDITVEQGTLHLLTLHKVTLEDAGTVSFH--VGTCSSEAQLKVTAKNTVVRGL 4346
Query: 3494 RTSVQTVVVGHAVEFECLALGDPKPQVTW----SKVGGHLRPGIVQSGGVVRIAHVELAD 3549
+V+ + G A+ FEC TW V +V +R +
Sbjct: 4347 E-NVEALEGGEAL-FECQLSQPEVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNL 4404
Query: 3550 AGQYRCTATNAAGTTQSHVLLLVQA--LPQISMPQEVRVPAGSAAVFPC-IASGYPTPDI 3606
Q C T AG + L V+ L + + V AG+ A F C ++ P +
Sbjct: 4405 RPQDSCRVTFLAGDMVTSAFLTVRGWRLEILEPLKNAAVRAGAQACFTCTLSEAVPVGEA 4464
Query: 3607 SWSKLDGSLPPD-------SRLENNMLMLPSVRPQDAG--TYVC 3641
SW ++ PD + ++ L+L S +P AG T+ C
Sbjct: 4465 SWYINGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFAC 4508
Score = 212 bits (539), Expect = 8e-54
Identities = 438/1843 (23%), Positives = 659/1843 (35%), Gaps = 295/1843 (16%)
Query: 1670 PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR-HQG 1728
P+ + AP + P +V G +L CQ+ G+P W + D +PV +G + R Q
Sbjct: 4 PQFSGAPRFL-TRPKAFVVSVGKDATLSCQIVGNPTPQVSWEK-DQQPVAAGARFRLAQD 61
Query: 1729 SELHFPSVQP---SDAGVYICTCRNLHQSNTSRAELLV--TEAPSKPITVTVEEQRSQSV 1783
+L+ ++ D+G Y+C RN + L V A ++ + S V
Sbjct: 62 GDLYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRV 121
Query: 1784 RPGADVTFICTAKSKSPAYTLVWT----RLHNGKLPTRAMDFNG---ILTIRNVQLSDAG 1836
R G++ TF C SP + W+ RL P ++ G L IR + D G
Sbjct: 122 REGSEATFRCRV-GGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG 180
Query: 1837 TYVCTGSNMFAMDQGTATLHV--QASGTLSAPVVS---------------------IHPP 1873
TY N A L V A+ T S P S PP
Sbjct: 181 TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPP 240
Query: 1874 Q-----LTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH--------GGILRL 1920
TV G+ A C TG P P W GQL + + H +L++
Sbjct: 241 STGTRTCTVTEGKHARLSCYVTGEPKPETVWK--KDGQLVTEGRRHVVYEDAQENFVLKI 298
Query: 1921 PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAA 1980
+ +D+ Y C A + GQ + ++ V P + + +V + C
Sbjct: 299 LFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVP-FKKRLQDLEVREKESATFLCEVP 357
Query: 1981 GVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAITTADAGFYLCVATSPAGT-AQA 2036
PS W KE L A+ E L + ++ D Y+C + T A+
Sbjct: 358 -QPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSRTVAEL 416
Query: 2037 RIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRR------GGS 2090
+Q +L K+ + +V G T + CV V W R GG
Sbjct: 417 AVQGNLLR---------KLPRKT-AVRVGDTA-MFCVELAVPVGPVHWLRNQEEVVAGGR 465
Query: 2091 LPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGS 2150
+ + L + Q D G+ G VS P PV +
Sbjct: 466 VAISAEGTRHTLTISQCCLEDVGQVAFMA--GDCQTSTQFCVSAPRKPPLQPPVDPVVKA 523
Query: 2151 TRPIRIEPSSSHVAEGQ---TLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQ 2207
+ S S G+ T+D +V + TW + + L
Sbjct: 524 RMESSVILSWSPPPHGERPVTID-GYLVEKKKLGTYTW------IRCHEAEWVATPELTV 576
Query: 2208 VTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQ----TLD 2263
A+ G + V + S + +V P VR + EG ++D
Sbjct: 577 ADVAEEGNFQFRVSALNS-FGQSPYLEFPGTVHLAPKLAVRTPLKAVQAVEGGEVTFSVD 635
Query: 2264 LSCVVAGQAHAQVTWYKRGGSLPAR-----HQVRGSRLYIFQASPADA-GQYVCRASNGM 2317
L+ AG+ W+ G +L A H R + PA G + +NG+
Sbjct: 636 LTVASAGE------WFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVANGI 689
Query: 2318 EASITVTVTGTQGANL-AYPAGSTQPI--RIEPSSSQVAEGQTLDLNCVVPGQSHAQVTW 2374
E+SI + V G PA + + + R+ + +AE A VTW
Sbjct: 690 ESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAE----------LSDQAAAVTW 739
Query: 2375 HKRGGSL------PVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAG 2428
K G +L V+ +L + + D+G Y C G + + SV
Sbjct: 740 LKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSV-------- 791
Query: 2429 SVPALGVTPTVRIESSSSQV--AEGQTLDLNCLVAGQAHAQVTWHKRGGSLPAR-----H 2481
G+ + + + S V G C +AH V W+K G L
Sbjct: 792 ----QGLARFLHKDMAGSCVDAVAGGPAQFEC-ETSEAHVHVHWYKDGMELGHSGERFLQ 846
Query: 2482 QVHGSRLRLL--QVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIE 2539
+ G+R RL+ VT D G Y CRV S + RL S + V ++
Sbjct: 847 EDVGTRHRLVAATVTRQDEGTYSCRVGEDS----------VDFRLRVSEPKVVFAKEQLA 896
Query: 2540 SSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI------VGSRLRIPQVTPA 2593
G + L+C VA QA +TWYK G L S ++ RL + Q A
Sbjct: 897 RRKLQAEAGASATLSCEVA-QAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQA 955
Query: 2594 DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVV 2653
D+GEY C AG + S + ++ V ++ S G + L+C V
Sbjct: 956 DAGEYSCE----AGGQRLSFHLDVK-----EPKVVFAKDQVAHSEVQAEAGASATLSCEV 1006
Query: 2654 ARQPQAIITWYKRGGSLPSRHQTH----GSHLRL--HQMSVADSGEYVCRANNNIDALEA 2707
A Q Q + WYK G L S + H G RL Q D+G+Y C A +
Sbjct: 1007 A-QAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEARGQRVSFRL 1065
Query: 2708 SIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSL 2767
I P ++ E+ +S + L+C V QA +VTW+K G L
Sbjct: 1066 HI---TEPKMMFAKEQSVHNEVQAEAGASAM-------LSCEV-AQAQTEVTWYKDGKKL 1114
Query: 2768 PSHH----QTRG--SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVP 2821
S + +G RL L AD+GEY C G S +H+
Sbjct: 1115 SSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQ--------------RVSFHLHIT 1160
Query: 2822 APGGAPPIRIEPSSSRVAE-GQTLDLKCVVPGQAHAQVTWHKRGGNLPA----RHQVHGP 2876
P G + AE G T L C V Q +VTW+K G L + R +V G
Sbjct: 1161 EPKGVFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKDGKKLSSSSKVRMEVKGC 1219
Query: 2877 LLRL--NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 2934
RL QV AD+GEYSC+ G + + + + P + A Q ++ E +
Sbjct: 1220 TRRLVVQQVGKADAGEYSCEAGGQRVSFQLHI------TEPKAVFAK--EQLVHNEVRTE 1271
Query: 2935 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA----RHQTHG--SQLRLHLVSPADSGE 2988
G + L+C V QA +VTWYK G L + R + G QL + AD+GE
Sbjct: 1272 ---AGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGE 1327
Query: 2989 YVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDG 3048
Y C A G V+ P + + +L + + G A+ C +
Sbjct: 1328 YTCEAG---GQRLSFHLDVSEPKAVFAKEQLAHRKVQ-------AEAGAIATLSCEVAQA 1377
Query: 3049 AAPISLEWKTRNQELEDNVHISPNGSIITIVGTR--PSNHGTYRCVASNAYGVAQSVVNL 3106
++ + V + G +V + ++ G Y C A G + +L
Sbjct: 1378 QTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCEA----GGQRLSFSL 1433
Query: 3107 SVHGPPTVSVLPEGPVWVKV----GKAVTLECVSAGEPRSSARWTRIS---STPAKLEQR 3159
V P V E PV +V G + TL C + ++ W + S +K+
Sbjct: 1434 DV-AEPKVVFAKEQPVHREVQAQAGASTTLSC-EVAQAQTEVMWYKDGKKLSFSSKVRME 1491
Query: 3160 TYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEA 3219
G V Q A AG Y C A +++ + + Q
Sbjct: 1492 AVGCTRRLVVQQAGQAV---AGEYSCEA------GSQRLSFHLHVAEPKAVFAKEQPASR 1542
Query: 3220 ELTVEAGHTATLRCSATGSPAPTIHW----SKLRSPLPWQHRLEGDT--LIIPRVAQQDS 3273
E+ EAG +ATL C + + W KL S + G T L++ Q D+
Sbjct: 1543 EVQAEAGTSATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADA 1601
Query: 3274 GQYICNATSPAGHAEATIILHVESPP--YATTVPEHASVQ--AGETVQLQC-LAHGTPPL 3328
G+Y C AG + LHV P +A P H VQ AG + L C +A +
Sbjct: 1602 GEYSCK----AGDQRLSFHLHVAEPKVVFAKEQPAHREVQAEAGASATLSCEVAQAQTEV 1657
Query: 3329 TFQWSRVGSSLPGRATARNEL------LHFERAAPEDSGRYRC 3365
T W + G L + R E L ++A D+G Y C
Sbjct: 1658 T--WYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSC 1698
Score = 207 bits (527), Expect = 2e-52
Identities = 419/1806 (23%), Positives = 626/1806 (34%), Gaps = 330/1806 (18%)
Query: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLS--APVVSIHPPQLTVQPGQL 1882
LTI ++ L D+G YVC N L V A + AP + P + V+ G
Sbjct: 67 LTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSE 126
Query: 1883 AEFRCSATGSPTPTLEWT------GGPGGQLPAKAQI-HGGILRLPAVEPTDQAQYLCRA 1935
A FRC GSP P + W+ G P G ++ LR+ A P D Y RA
Sbjct: 127 ATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRA 186
Query: 1936 HSSAGQQVARAVLHVHGGGGPRVQ--------------------------VSPERT---- 1965
+ G A A L V SP T
Sbjct: 187 ENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRT 246
Query: 1966 -QVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR----SERTDIATLLIPAITTADA 2020
V G+ RL C G P W+K+G + R + + L I +D
Sbjct: 247 CTVTEGKHARLSCYVTGEPKPETVWKKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDR 306
Query: 2021 GFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA 2080
G Y C A++ G + + VVV + P K V E ++ C V
Sbjct: 307 GLYTCTASNLVGQTYSSVLVVVREPA----VPFKKRLQDLEVREKESATFLCEVP-QPST 361
Query: 2081 QVTWY----RRGGSLPPHTQVHGS--RLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
+ W+ R S + G+ RL + VS D Y+C GS TV+
Sbjct: 362 EAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGSR------TVAE 415
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKR------ 2188
L V G+ +R P + V G T + CV V W +
Sbjct: 416 L----------AVQGNL--LRKLPRKTAVRVGDTA-MFCVELAVPVGPVHWLRNQEEVVA 462
Query: 2189 GGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV- 2247
GG + + L + Q D G+ V +G + S + A P PPV
Sbjct: 463 GGRVAISAEGTRHTLTISQCCLEDVGQ----VAFMAGDCQTSTQFCVSAPRKPPLQPPVD 518
Query: 2248 -----RIESSS----STVAEGQ---TLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSR 2295
R+ESS S G+ T+D +V + TW + V
Sbjct: 519 PVVKARMESSVILSWSPPPHGERPVTID-GYLVEKKKLGTYTWIR----CHEAEWVATPE 573
Query: 2296 LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEG 2355
L + + Q+ A N S + GT +LA P++ + Q EG
Sbjct: 574 LTVADVAEEGNFQFRVSALNSFGQSPYLEFPGT--VHLAPKLAVRTPLK----AVQAVEG 627
Query: 2356 Q----TLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSG---EYVCR 2408
++DL G+ K + L + + + G ++V
Sbjct: 628 GEVTFSVDLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVAN 687
Query: 2409 VLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQV 2468
+ SS+ +E + A R+ + +AE ++ QA A V
Sbjct: 688 GIESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAE---------LSDQA-AAV 737
Query: 2469 TWHKRGGSLP--ARHQVHGSR----LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522
TW K G +L +++V S L + V D+G Y C G + SV
Sbjct: 738 TWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSV------ 791
Query: 2523 RLSGSHSQGVAYPVR--IESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSR--- 2577
QG+A + + S G C S+A + WYK G L
Sbjct: 792 -------QGLARFLHKDMAGSCVDAVAGGPAQFEC-ETSEAHVHVHWYKDGMELGHSGER 843
Query: 2578 --HQIVGSRLRI--PQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIR 2633
+ VG+R R+ VT D G Y C V G S + L V S V +
Sbjct: 844 FLQEDVGTRHRLVAATVTRQDEGTYSCRV--GEDSVDFRLRV-------SEPKVVFAKEQ 894
Query: 2634 IESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH----QTHGSHLRL--HQMS 2687
+ G + L+C VA Q Q +TWYK G L S + G RL Q
Sbjct: 895 LARRKLQAEAGASATLSCEVA-QAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLVVQQAG 953
Query: 2688 VADSGEYVCRANN-----NIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGE 2742
AD+GEY C A ++D E +V + ++ S G
Sbjct: 954 QADAGEYSCEAGGQRLSFHLDVKEPKVVFAKD---------------QVAHSEVQAEAGA 998
Query: 2743 TLDLNCVVPGQAHAQVTWHKRG----GSLPSHHQTRGSRLRL--HHVSPADSGEYVCRVM 2796
+ L+C V QA +V W+K G SL H + +G R RL D+G+Y C
Sbjct: 999 SATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEAR 1057
Query: 2797 GSSGPL-----EASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVP 2851
G E ++ E S + V A G + L C V
Sbjct: 1058 GQRVSFRLHITEPKMMFAKEQSVHNEVQAEA------------------GASAMLSCEV- 1098
Query: 2852 GQAHAQVTWHKRGGNLPARHQVHGPL------LRLNQVSPADSGEYSCQVTGSSGTLEAS 2905
QA +VTW+K G L + +V + L L Q AD+GEYSC+ G +
Sbjct: 1099 AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLH 1158
Query: 2906 VLVTIEPSSPGPIPAPGLAQPIYIEASSSH----VTEGQTLDLNCVVPGQAHAQVTWYKR 2961
+ EP ++ + S H G T L+C V Q +VTWYK
Sbjct: 1159 I---TEPKG------------VFAKEQSVHNEVQAEAGTTAMLSCEV-AQPQTEVTWYKD 1202
Query: 2962 GGSLPA----RHQTHGSQLRL--HLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGS 3015
G L + R + G RL V AD+GEY C A Q SF + + +E
Sbjct: 1203 GKKLSSSSKVRMEVKGCTRRLVVQQVGKADAGEYSCEAGG-----QRVSFQLHI--TEPK 1255
Query: 3016 SYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSI 3075
+ + ++ + + G A+ C + ++ + V I G +
Sbjct: 1256 AVFAKEQLVHNE---VRTEAGASATLSCEVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCM 1312
Query: 3076 --ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV---SVLPEGPVWVKVGKAV 3130
+ + ++ G Y C A G + +L V P V L V + G
Sbjct: 1313 RQLVVQQAGQADAGEYTCEA----GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIA 1368
Query: 3131 TLECVSAGEPRSSARWTRIS---STPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLA 3187
TL C + ++ W + S+ +K+ G L + A +D G Y C A
Sbjct: 1369 TLSC-EVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRR---LVVQQACQADTGEYSCEA 1424
Query: 3188 QNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK 3247
+++ +D + Q E+ +AG + TL C + + W K
Sbjct: 1425 ------GGQRLSFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEVAQAQT-EVMWYK 1477
Query: 3248 LRSPLPWQHRLEGDT------LIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPP-- 3299
L + ++ + L++ + Q +G+Y C AG + LHV P
Sbjct: 1478 DGKKLSFSSKVRMEAVGCTRRLVVQQAGQAVAGEYSCE----AGSQRLSFHLHVAEPKAV 1533
Query: 3300 YATTVPEHASVQ--AGETVQLQC-LAHGTPPLTFQWSRVGSSLPGRATARNEL------L 3350
+A P VQ AG + L C +A +T W + G L + R E L
Sbjct: 1534 FAKEQPASREVQAEAGTSATLSCEVAQAQTEVT--WYKDGKKLSSSSKVRMEAVGCTRRL 1591
Query: 3351 HFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLET 3410
+ A D+G Y C K G L V P + A PA +
Sbjct: 1592 VVQEAGQADAGEYSC----KAGDQRLSFHLHV-AEPKVVFAKEQPAHREVQAEA------ 1640
Query: 3411 KSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV------LRIQNLDQSCQGTY 3464
GAS C V + T++ W+K+G +L V+ L +Q Q+ G Y
Sbjct: 1641 ---GASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEY 1696
Query: 3465 ICQAHG 3470
C+A G
Sbjct: 1697 SCEAGG 1702
Score = 201 bits (511), Expect = 1e-50
Identities = 422/1837 (22%), Positives = 649/1837 (35%), Gaps = 291/1837 (15%)
Query: 1954 GGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQAR---SERTDIATL 2010
G PR P+ V G+ L C+ G P+ ++W K+ + AR ++ D+ L
Sbjct: 8 GAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRL 67
Query: 2011 LIPAITTADAGFYLCVATSPAGTAQARI--QVVVLSASDASPPPVKIESSSPSVTEGQTL 2068
I + D+G Y+C A + G A A + QV +A P + +S V EG
Sbjct: 68 TILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGSEA 127
Query: 2069 DLNCVVAGSAHAQVTWYRRGGSL----PPHTQV----HGSRLRLPQVSPADSGEYVCRVE 2120
C V GS V+W + G L P +V S LR+ P D G Y R E
Sbjct: 128 TFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAE 187
Query: 2121 NGSGPKEASITVSV---------LHGTHSGPSYTPVPGSTRPIRIE------PSSS---- 2161
N G A+ + V GT + + +R E PS+
Sbjct: 188 NPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTRTC 247
Query: 2162 HVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTH--------GSLLRLHQVTPADS 2213
V EG+ L+C V G+ + W K+ G L + H +L++ +D
Sbjct: 248 TVTEGKHARLSCYVTGEPKPETVW-KKDGQLVTEGRRHVVYEDAQENFVLKILFCKQSDR 306
Query: 2214 GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAH 2273
G Y C G +SVLV V+ P P + V E ++ C V Q
Sbjct: 307 GLYTCTASNLVGQTYSSVLV-----VVREPAVPFKKRLQDLEVREKESATFLCEVP-QPS 360
Query: 2274 AQVTWYKRGGSLPA------RHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTG 2327
+ W+K L A + RL + S D Y+C G S TV
Sbjct: 361 TEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEG---SRTVAELA 417
Query: 2328 TQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKR------GGSL 2381
QG NL +R P + V G T + CV V W + GG +
Sbjct: 418 VQG-NL---------LRKLPRKTAVRVGDTA-MFCVELAVPVGPVHWLRNQEEVVAGGRV 466
Query: 2382 PVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRI 2441
+ + L + Q D G+ + V +P P V P V+
Sbjct: 467 AISAEGTRHTLTISQCCLEDVGQVAFMAGDCQTSTQFCVSAPRKPPLQPP---VDPVVKA 523
Query: 2442 ESSSSQVAEGQ---------TLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQ 2492
SS + T+D LV + TW + H+ L
Sbjct: 524 RMESSVILSWSPPPHGERPVTID-GYLVEKKKLGTYTWIR-------CHEAEWVATPELT 575
Query: 2493 VTP-ADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGH-- 2549
V A+ G + RV + ++ L G+ VR + G
Sbjct: 576 VADVAEEGNFQFRVSALNSFGQSPYL-----EFPGTVHLAPKLAVRTPLKAVQAVEGGEV 630
Query: 2550 TLDLNCLVASQAPHTITWYKRGGSL--PSRHQIVGSRLR----IPQVTPADSGEYVCHVS 2603
T ++ VAS W+ G +L S ++I R R I +V + G + V+
Sbjct: 631 TFSVDLTVASAG----EWFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVA 686
Query: 2604 NGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITW 2663
NG S + G ++ P+ + E + E Q L A +TW
Sbjct: 687 NGIESSIRMEVRAAPGLTANKPPAAAAR---EVLARLHEEAQLL----AELSDQAAAVTW 739
Query: 2664 YKRGGSLP--SRHQTHGSH----LRLHQMSVADSGEYVCRANNNIDALEASIV----ISV 2713
K G +L +++ S L + ++ D+G Y C + A + S+
Sbjct: 740 LKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLH 799
Query: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT 2773
AGS + P + E +S +AH V W+K G L H
Sbjct: 800 KDMAGSCVDAVAGGPAQFECETS----------------EAHVHVHWYKDGMEL-GHSGE 842
Query: 2774 R------GSRLRL--HHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGG 2825
R G+R RL V+ D G Y CRV E SV + S V
Sbjct: 843 RFLQEDVGTRHRLVAATVTRQDEGTYSCRVG------EDSVDFRLRVSEPKVVFAKEQLA 896
Query: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQV----HGPLLRL- 2880
++ E G + L C V QA +VTW+K G L + +V G RL
Sbjct: 897 RRKLQAE-------AGASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATGCTRRLV 948
Query: 2881 -NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEG 2939
Q AD+GEYSC+ G + V P + A ++A + G
Sbjct: 949 VQQAGQADAGEYSCEAGGQRLSFHLDV------KEPKVVFAKDQVAHSEVQAEA-----G 997
Query: 2940 QTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH----GSQLRL--HLVSPADSGEYVCRA 2993
+ L+C V QA +V WYK G L + + H G + RL D+G+Y C A
Sbjct: 998 ASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSCEA 1056
Query: 2994 ASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPIS 3053
Q SF + + + + +S + + G A C + ++
Sbjct: 1057 RG-----QRVSFRLHITEPKMMFAKEQSVHNEVQ-----AEAGASAMLSCEVAQAQTEVT 1106
Query: 3054 LEWKTRNQELEDNVHISPNGSI--ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
+ V + G + + ++ G Y C A G + +L + P
Sbjct: 1107 WYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEA----GGQRVSFHLHITEP 1162
Query: 3112 PTVSVLPE---GPVWVKVGKAVTLECVSAGEPRSSARWTRIS---STPAKLEQRTYGLMD 3165
V + V + G L C +P++ W + S+ +K+ G
Sbjct: 1163 KGVFAKEQSVHNEVQAEAGTTAMLSC-EVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTR 1221
Query: 3166 SHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEA 3225
V Q+ A DAG Y C A + Q + T A A + Q E+ EA
Sbjct: 1222 RLVVQQVGKA---DAGEYSCEAGGQRVSFQLHI-----TEPKAVFAKE-QLVHNEVRTEA 1272
Query: 3226 GHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDT------LIIPRVAQQDSGQYICN 3279
G +ATL C + + W K L ++ + L++ + Q D+G+Y C
Sbjct: 1273 GASATLSCEVAQAQT-EVTWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAGEYTCE 1331
Query: 3280 ATSPAGHAEATIILHVESPP--YATTVPEHASVQ--AGETVQLQC-LAHGTPPLTFQWSR 3334
AG + L V P +A H VQ AG L C +A +T W +
Sbjct: 1332 ----AGGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEVAQAQTEVT--WYK 1385
Query: 3335 VGSSLPGRATARNEL------LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGS 3388
G L + R E L ++A D+G Y C + + L P
Sbjct: 1386 DGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCE-----AGGQRLSFSLDVAEPKV 1440
Query: 3389 LPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQD 3448
+ A P Q GAS C V + T++ W+K+G +L V+
Sbjct: 1441 VFAKEQPVHREVQAQA---------GASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRM 1490
Query: 3449 GV------LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTV-- 3500
L +Q Q+ G Y C+A G + S L + +V + + + V
Sbjct: 1491 EAVGCTRRLVVQQAGQAVAGEYSCEA----GSQRLSFHLHVAEPKAVFAKEQPASREVQA 1546
Query: 3501 VVGHAVEFECLALGDPKPQVTWSKVGGHLRPGI---VQSGGVVR---IAHVELADAGQYR 3554
G + C + + +VTW K G L +++ G R + ADAG+Y
Sbjct: 1547 EAGTSATLSC-EVAQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYS 1605
Query: 3555 CTATNAAGTTQSHVL--LLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLD 3612
C A + + HV +V A Q +EV+ AG++A C + T +++W K
Sbjct: 1606 CKAGDQRLSFHLHVAEPKVVFAKEQ-PAHREVQAEAGASATLSCEVAQAQT-EVTWYKDG 1663
Query: 3613 GSLPPDSRLE------NNMLMLPSVRPQDAGTYVCTA 3643
L S++ L++ DAG Y C A
Sbjct: 1664 KKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEA 1700
Score = 195 bits (495), Expect = 9e-49
Identities = 429/1875 (22%), Positives = 659/1875 (35%), Gaps = 324/1875 (17%)
Query: 1865 APVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH------GGIL 1918
AP P V G+ A C G+PTP + W Q P A G +
Sbjct: 9 APRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSW---EKDQQPVAAGARFRLAQDGDLY 65
Query: 1919 RLPAVEPT--DQAQYLCRAHSSAGQQVARAVLHVHGGG-----GPRVQVSPERTQVHAGR 1971
RL ++ D QY+CRA ++ G+ A L V P + P +V G
Sbjct: 66 RLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAPHFLLRPTSIRVREGS 125
Query: 1972 TVRLYCRAAGVPSATITWRKEGGSL----PPQARSERT-DIATLLIPAITTADAGFYLCV 2026
CR G P ++W K+G L P+ R E + + L I A D G Y
Sbjct: 126 EATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGGTYEVR 185
Query: 2027 ATSPAGTAQARIQVVV----------------------------LSASDASPPPVKIESS 2058
A +P G A A +VV + A A P +
Sbjct: 186 AENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPPSTGTR 245
Query: 2059 SPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVH--------GSRLRLPQVSPA 2110
+ +VTEG+ L+C V G + W ++ G L + H L++ +
Sbjct: 246 TCTVTEGKHARLSCYVTGEPKPETVW-KKDGQLVTEGRRHVVYEDAQENFVLKILFCKQS 304
Query: 2111 DSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLD 2170
D G Y C N G +S+ V V VP R +E V E ++
Sbjct: 305 DRGLYTCTASNLVGQTYSSVLVVVRE--------PAVPFKKRLQDLE-----VREKESAT 351
Query: 2171 LNCVVPGQAHAQVTWHKRGGSLPARH----QTHGSLLRL--HQVTPADSGEYVCHVVGTS 2224
C VP Q + W K L A + G+ RL V+ D Y+C S
Sbjct: 352 FLCEVP-QPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPEGS 410
Query: 2225 GPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKR--- 2281
T+ + G + +R + V G T + CV V W +
Sbjct: 411 R--------TVAELAVQGNL--LRKLPRKTAVRVGDTA-MFCVELAVPVGPVHWLRNQEE 459
Query: 2282 ---GGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAG 2338
GG + + L I Q D GQ A + + S V+ + L P
Sbjct: 460 VVAGGRVAISAEGTRHTLTISQCCLEDVGQVAFMAGD-CQTSTQFCVSAPRKPPLQPPVD 518
Query: 2339 STQPIRIEPSS----SQVAEGQ---TLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSL 2391
R+E S S G+ T+D +V + TW + +
Sbjct: 519 PVVKARMESSVILSWSPPPHGERPVTID-GYLVEKKKLGTYTW------IRCHEAEWVAT 571
Query: 2392 LRLYQASPADSGEYVCRV-----LGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSS 2446
L A A+ G + RV G S LE V + P VR +
Sbjct: 572 PELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHLAP---------KLAVRTPLKAV 622
Query: 2447 QVAEGQ----TLDLNCLVAGQAHAQVTWHKRGGSLPAR--HQVHGSRLR-LLQVTPADSG 2499
Q EG ++DL AG+ W G +L A +++H R R L + +
Sbjct: 623 QAVEGGEVTFSVDLTVASAGE------WFLDGQALKASSVYEIHCDRTRHTLTIREVPAS 676
Query: 2500 EYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVAS 2559
+ ++ + E+S+ + ++ + ++ A R LA H S
Sbjct: 677 LHGAQLKFVANGIESSIRMEVRAAPGLTANKPPAAAAR-----EVLARLHEEAQLLAELS 731
Query: 2560 QAPHTITWYKRGGSLP--SRHQIVGSR----LRIPQVTPADSGEYVCHVSNGAGSRETSL 2613
+TW K G +L ++++ S L + V D+G Y C VS G +
Sbjct: 732 DQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYEC-VSRGG---RIAY 787
Query: 2614 IVTIQG-SGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS 2672
+++QG + H + + P E +T + + WYK G L
Sbjct: 788 QLSVQGLARFLHKDMAGSCVDAVAGGPAQFECET--------SEAHVHVHWYKDGMELGH 839
Query: 2673 R-----HQTHGSHLRLHQMSVA--DSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGS 2725
+ G+ RL +V D G Y CR D+++ + +S P +
Sbjct: 840 SGERFLQEDVGTRHRLVAATVTRQDEGTYSCRVGE--DSVDFRLRVS-EPKVVFAKEQLA 896
Query: 2726 SMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQ--------TRGSR 2777
++ E+ G + L+C V QA +VTW+K G L S + TR R
Sbjct: 897 RRKLQAEA-------GASATLSCEV-AQAQTEVTWYKDGKKLSSSSKVCMEATGCTR--R 946
Query: 2778 LRLHHVSPADSGEYVCRVMGS--SGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSS 2835
L + AD+GEY C G S L+ + A ++ S
Sbjct: 947 LVVQQAGQADAGEYSCEAGGQRLSFHLDVKEPKVVFAKD---------------QVAHSE 991
Query: 2836 SRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL------LRLNQVSPADSG 2889
+ G + L C V QA +V W+K G L + +VH L + Q D+G
Sbjct: 992 VQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAG 1050
Query: 2890 EYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVP 2949
+YSC+ G V + + P + A Q ++ E + G + L+C V
Sbjct: 1051 DYSCEARGQ------RVSFRLHITEPKMMFAK--EQSVHNEVQAE---AGASAMLSCEV- 1098
Query: 2950 GQAHAQVTWYKRGGSLPARH----QTHGSQLRLHL--VSPADSGEYVCRAASGPGPEQEA 3003
QA +VTWYK G L + + G RL L AD+GEY C A Q
Sbjct: 1099 AQAQTEVTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGG-----QRV 1153
Query: 3004 SFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL 3063
SF + + +G + +S + + G A C + ++ +
Sbjct: 1154 SFHLHITEPKGVFAKEQSVHNEVQ-----AEAGTTAMLSCEVAQPQTEVTWYKDGKKLSS 1208
Query: 3064 EDNVHISPNGSI--ITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV---SVLP 3118
V + G + + ++ G Y C A G + L + P V L
Sbjct: 1209 SSKVRMEVKGCTRRLVVQQVGKADAGEYSCEA----GGQRVSFQLHITEPKAVFAKEQLV 1264
Query: 3119 EGPVWVKVGKAVTLECVSAGEPRSSARWTRIS---STPAKLEQRTYGLMDSHAVLQISSA 3175
V + G + TL C + ++ W + S+ +K+ G M L + A
Sbjct: 1265 HNEVRTEAGASATLSC-EVAQAQTEVTWYKDGKKLSSSSKVRIEAAGCMRQ---LVVQQA 1320
Query: 3176 KPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSA 3235
+DAG Y C A +++ +D + Q ++ EAG ATL C
Sbjct: 1321 GQADAGEYTCEA------GGQRLSFHLDVSEPKAVFAKEQLAHRKVQAEAGAIATLSCEV 1374
Query: 3236 TGSPAPTIHW----SKLRSPLPWQHRLEGDT--LIIPRVAQQDSGQYICNATSPAGHAEA 3289
+ + W KL S + G T L++ + Q D+G+Y C AG
Sbjct: 1375 AQAQT-EVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCE----AGGQRL 1429
Query: 3290 TIILHVESPP--YATTVPEHASV--QAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATA 3345
+ L V P +A P H V QAG + L C W + G L +
Sbjct: 1430 SFSLDVAEPKVVFAKEQPVHREVQAQAGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKV 1488
Query: 3346 RNEL------LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGST 3399
R E L ++A +G Y C + GS L V P ++ A PA
Sbjct: 1489 RMEAVGCTRRLVVQQAGQAVAGEYSC----EAGSQRLSFHLHV-AEPKAVFAKEQPASRE 1543
Query: 3400 PTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQDGV------LRI 3453
+ G S C V + T++ W+K+G +L V+ L +
Sbjct: 1544 VQAEA---------GTSATLSCEV-AQAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVV 1593
Query: 3454 QNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVV---VGHAVEFEC 3510
Q Q+ G Y C+A G + S L + A P V+ V G + C
Sbjct: 1594 QEAGQADAGEYSCKA----GDQRLSFHLHV-AEPKVVFAKEQPAHREVQAEAGASATLSC 1648
Query: 3511 LALGDPKPQVTWSKVGGHLRPGI---VQSGGVVR---IAHVELADAGQYRCTATNAAGTT 3564
+ + +VTW K G L V++ G R + ADAG+Y C A G
Sbjct: 1649 -EVAQAQTEVTWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSC---EAGGQR 1704
Query: 3565 QSHVLLLVQALPQIS 3579
S L + + PQIS
Sbjct: 1705 LSFRLHVAELEPQIS 1719
Score = 191 bits (485), Expect = 1e-47
Identities = 439/1819 (24%), Positives = 661/1819 (36%), Gaps = 353/1819 (19%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGT--QQRHQGSE--LHFPSVQPSDAGV 1743
V +G S S C +S G+ V S + Q QG + L PSDAG
Sbjct: 2747 VLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGE 2806
Query: 1744 YICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICT-AKSKSPAY 1802
+ + R L TS+A L+V E P+ ++ Q V PG DV C +++ +P +
Sbjct: 2807 VVFSVRGL----TSKASLIVRERPA----AIIKPLEDQWVAPGEDVELRCELSRAGTPVH 2858
Query: 1803 TLVWTRLHNGKLPTRAMDF-----NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV 1857
W + ++ D +L IR L DAG Y C + TA+LHV
Sbjct: 2859 ---WLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCE----VEASKSTASLHV 2911
Query: 1858 QASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGG------PGGQLPAKA 1911
+ ++ L V+ A F C T P T+ W G G P++
Sbjct: 2912 EEKANCFTEELT----NLQVEEKGTAVFTCK-TEHPAATVTWRKGLLELRASGKHQPSQ- 2965
Query: 1912 QIHGGILRL--PAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQV--SPERTQV 1967
G LRL A+E D Y C GQ +RA L V G RV + E V
Sbjct: 2966 --EGLTLRLTISALEKADSDTYTC----DIGQAQSRAQLLVQ---GRRVHIIEDLEDVDV 3016
Query: 1968 HAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSE----RTDIATLLIPAITTADAGFY 2023
G + CR + + W + L +E L + + D+G
Sbjct: 3017 QEGSSATFRCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLTLRQLALKDSGTI 3076
Query: 2024 LCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2083
A +A R+ P E + ++TEG+ L L C + + V
Sbjct: 3077 YFEAGDQRASAALRV--------TEKPSVFSRELTDATITEGEDLTLVCETS-TCDIPVC 3127
Query: 2084 WYRRGGSLPPHTQV------HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHG 2137
W + G +L + H ++L + + DSG Y C E G + + V
Sbjct: 3128 WTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKC--EAGGACSSSIVRV----- 3180
Query: 2138 THSGPSYTPVPGSTRPIRIEPS--SSHVAEGQTLDLNCVVPGQAHAQVTW------HKRG 2189
RP+R + + V EG L CV+ A A V W + G
Sbjct: 3181 ------------HARPVRFQEALKDLEVLEGGAATLRCVLSSVA-APVKWCYGNNVLRPG 3227
Query: 2190 GSLPARHQTHGSLLRL--HQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
R + G++L L + P DSG Y C + G S +T+ A +P
Sbjct: 3228 DKYSLRQE--GAMLELVVRNLRPQDSGRYSC----SFGDQTTSATLTVTA------LPAQ 3275
Query: 2248 RI-ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLP------ARHQVRGSRLYIFQ 2300
I + + EG T L C ++ A V W K +L R L I
Sbjct: 3276 FIGKLRNKEATEGATATLRCELS--KAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRG 3333
Query: 2301 ASPADAGQYVC-RASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLD 2359
+ DA +Y C AS+T+ PA +R + S EG T
Sbjct: 3334 LAMVDAAEYSCVCGEERTSASLTIR---------PMPAHFIGRLRHQES----IEGATAT 3380
Query: 2360 LNCVVPGQSHAQVTWHKRGGSL------PVRHQTHGSLLRLYQASPADSGEYVCRVLGSS 2413
L C + A V W K SL +R L++ + AD+GEY C V G
Sbjct: 3381 LRCEL--SKAAPVEWRKGRESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSC-VCGEE 3437
Query: 2414 VPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHK- 2472
A++ V PA L + + EG T L C ++ A V W K
Sbjct: 3438 -RTSATLTVKALPAKFTEGL----------RNEEAVEGATAMLWCELS--KVAPVEWRKG 3484
Query: 2473 -----RGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGS 2527
G R + L++ + AD+GEY+C G + S +TI+
Sbjct: 3485 PENLRDGDRYILRQEGTRCELQICGLAMADAGEYLC----VCGQERTSATLTIR------ 3534
Query: 2528 HSQGVAYPVRI--ESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS------RHQ 2579
A P R + + G T L C + S AP + W K +L R
Sbjct: 3535 -----ALPARFIEDVKNQEAREGATAVLQCELNSAAP--VEWRKGSETLRDGDRYSLRQD 3587
Query: 2580 IVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESS-- 2637
L+I + AD+GEY C G TS ++T++ + PI+
Sbjct: 3588 GTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVR----------ALPIKFTEGLR 3633
Query: 2638 SPTVVEGQTLDLNCVVARQPQAIITWYK-----RGGSLPSRHQTHG-SHLRLHQMSVADS 2691
+ EG T L C +++ A + W+K R G S Q L++ + D+
Sbjct: 3634 NEEATEGATAVLRCELSK--MAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDA 3691
Query: 2692 GEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVP 2751
GEY+C + A + + PS +R E ++ EG+T L C +
Sbjct: 3692 GEYLCMCGK--ERTSAMLTVRAMPSKFIEG-------LRNEEAT----EGDTATLWCEL- 3737
Query: 2752 GQAHAQVTWHK-----RGGSLPSHHQTRGSR--LRLHHVSPADSGEYVCRVMGSSGPLEA 2804
A V W K R G S Q GSR L++ ++ D+GEY C G
Sbjct: 3738 -SKAAPVEWRKGHETLRDGDRHSLRQD-GSRCELQIRGLAVVDAGEYSC----VCGQERT 3791
Query: 2805 SVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHK-- 2862
S +T+ A + + + + EG T L+C + A V W K
Sbjct: 3792 SATLTVRALPARFIE------------DVKNQEAREGATAVLQCEL--SKAAPVEWRKGS 3837
Query: 2863 ---RGGN-LPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPI 2918
RGG+ R L+++ +S AD+GEYSC V G T S +T+
Sbjct: 3838 ETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC-VCGQERT---SATLTVR------A 3887
Query: 2919 PAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA------RHQTH 2972
P P +P+ S EG T L C + + A V W K G L A R Q
Sbjct: 3888 PQPVFREPL----QSLQAEEGSTATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGC 3942
Query: 2973 GSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST 3032
++L L + D+GEY C S Q S T+TV + R +
Sbjct: 3943 TAELVLQDLQREDTGEYTCTCGS-----QATSATLTVTAAPVRFLR--------ELQHQE 3989
Query: 3033 VQQGQDASFKCLIHDGAAPISLEWKTRNQELED--NVHISPNGSI--ITIVGTRPSNHGT 3088
V +G A C + A S+EW+ + +L + +G+ + + G + G
Sbjct: 3990 VDEGGTAHLCCELSRAGA--SVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGD 4047
Query: 3089 YRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC-VSAGEPRSSARWT 3147
Y C G QS+ +LSV P + + G L C +S E + +W
Sbjct: 4048 YTCDT----GHTQSMASLSVRVPRPKFKTRLQSLEQETGDIARLCCQLSDAESGAVVQWL 4103
Query: 3148 R----ISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQV---EV 3200
+ + + P K E R+ G + L I + D G Y C+ A +V EV
Sbjct: 4104 KEGVELHAGP-KYEMRSQG---ATRELLIHQLEAKDTGEYACVTGGQKTAASLRVTEPEV 4159
Query: 3201 IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG 3260
+ G + +AE+T A C + + A + W PL E
Sbjct: 4160 TIVRGLV----------DAEVT--ADEDVEFSCEVSRAGATGVQWCLQGLPLQSNEVTEV 4207
Query: 3261 -------DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP-EHASVQA 3312
TL + V +D+G + + A A+ T V +P P + +
Sbjct: 4208 AVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLT----VRAPEVTILEPLQDVQLSE 4263
Query: 3313 GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNE---------LLHFERAAPEDSGRY 3363
G+ QC +W+ G +P +A N+ LL + ED+G
Sbjct: 4264 GQDASFQCRLSRASGQEARWALGG--VPLQANEMNDITVEQGTLHLLTLHKVTLEDAG-- 4319
Query: 3364 RCRVTNKVGSAEAFAQLLV 3382
V+ VG+ + AQL V
Sbjct: 4320 --TVSFHVGTCSSEAQLKV 4336
Score = 184 bits (467), Expect = 2e-45
Identities = 495/2147 (23%), Positives = 770/2147 (35%), Gaps = 405/2147 (18%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS----ELHFPSVQPSDAGVYIC 1746
G S +L C+V+ + ++ +DG+ + S + + L +DAG Y C
Sbjct: 997 GASATLSCEVAQAQTEVMWY--KDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAGDYSC 1054
Query: 1747 TCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVW 1806
R S L +TE P GA C + A T V
Sbjct: 1055 EARGQRVS----FRLHITE-PKMMFAKEQSVHNEVQAEAGASAMLSCEV---AQAQTEVT 1106
Query: 1807 TRLHNGKLPTRA---MDFNGI---LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS 1860
KL + + M+ G L + +DAG Y C + + LH+
Sbjct: 1107 WYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQ----RVSFHLHITEP 1162
Query: 1861 GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP--GGQLPAKAQIHGGIL 1918
+ A S+H ++ + G A C T + G + ++ G
Sbjct: 1163 KGVFAKEQSVHN-EVQAEAGTTAMLSCEVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTR 1221
Query: 1919 RLPA--VEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGG--PRVQVSPERTQVHAGRTVR 1974
RL V D +Y C A GQ+V+ LH+ + Q+ + AG +
Sbjct: 1222 RLVVQQVGKADAGEYSCEA---GGQRVSFQ-LHITEPKAVFAKEQLVHNEVRTEAGASAT 1277
Query: 1975 LYCRAAGVPSATITWRKEGGSLPPQARSERTDIA----TLLIPAITTADAGFYLCVATSP 2030
L C A + +TW K+G L ++ R + A L++ ADAG Y C
Sbjct: 1278 LSCEVAQAQTE-VTWYKDGKKLSSSSKV-RIEAAGCMRQLVVQQAGQADAGEYTC----E 1331
Query: 2031 AGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGS 2090
AG + + V S A ++ G L+C VA A +VTWY+ G
Sbjct: 1332 AGGQRLSFHLDV-SEPKAVFAKEQLAHRKVQAEAGAIATLSCEVA-QAQTEVTWYKDGKK 1389
Query: 2091 LPPHTQVHGS------RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSY 2144
L ++V RL + Q AD+GEY C +G + S ++ V
Sbjct: 1390 LSSSSKVRMEAVGCTRRLVVQQACQADTGEYSCE----AGGQRLSFSLDVAEPK------ 1439
Query: 2145 TPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLP----ARHQTHG 2200
V +P+ E + G + L+C V QA +V W+K G L R + G
Sbjct: 1440 -VVFAKEQPVHREVQAQ---AGASTTLSCEV-AQAQTEVMWYKDGKKLSFSSKVRMEAVG 1494
Query: 2201 SLLRL--HQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAE 2258
RL Q A +GEY C S L + V +V P R + +
Sbjct: 1495 CTRRLVVQQAGQAVAGEYSCEA--GSQRLSFHLHVAEPKAVFAKEQPASREVQAEA---- 1548
Query: 2259 GQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR------GSRLYIFQASPADAGQYVCR 2312
G + LSC VA QA +VTWYK G L + +VR RL + +A ADAG+Y C+
Sbjct: 1549 GTSATLSCEVA-QAQTEVTWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAGQADAGEYSCK 1607
Query: 2313 ASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQV 2372
A + S + V A QP E Q G + L+C V Q+ +V
Sbjct: 1608 AGD-QRLSFHLHV-----AEPKVVFAKEQPAHRE---VQAEAGASATLSCEV-AQAQTEV 1657
Query: 2373 TWHKRG----GSLPVRHQTHGSLLRL--YQASPADSGEYVCRVLGSSVPLEASVLVTIEP 2426
TW+K G S VR + G RL QA AD+GEY C G + V +EP
Sbjct: 1658 TWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAGQADAGEYSCEAGGQRLSFRLHV-AELEP 1716
Query: 2427 AGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL--PARHQ-- 2482
S P V V E + + L +A + A VTW K G + RH+
Sbjct: 1717 QISERPCRREPLV--------VKEHEDIILTATLATPSAATVTWLKDGVEIRRSKRHETA 1768
Query: 2483 ---------VHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVA 2533
VHG+++ DS Y CRV ++G
Sbjct: 1769 SQGDTHTLTVHGAQV-------LDSAIYSCRV----------------------GAEGQD 1799
Query: 2534 YPVRIESSSASLAN---------GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSR 2584
+PV++E +A G T+ L C + S A + W R G+ R VG R
Sbjct: 1800 FPVQVEEVAAKFCRLLEPVCGELGGTVTLACEL-SPACAEVVW--RCGNTQLR---VGKR 1853
Query: 2585 LRIPQVTPA-----------DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIR 2633
++ P D+GEYVC + TS +T+ SV ++
Sbjct: 1854 FQMVAEGPVRSLTVLGLRAEDAGEYVCE----SRDDHTSAQLTV---------SVPRVVK 1900
Query: 2634 IESSSPTVV--EGQTLDLNCVVARQPQAIITWYKRGGSL-PSR----HQTHGSH-LRLHQ 2685
S TVV EG CVV+ A++ W++ G L PS Q+ SH L +
Sbjct: 1901 FMSGLSTVVAEEGGEATFQCVVSPSDVAVV-WFRDGALLQPSEKFAISQSGASHSLTISD 1959
Query: 2686 MSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPI----RIESSSSHVAEG 2741
+ + D+G+ I + ++ S + P+ ++E +
Sbjct: 1960 LVLEDAGQ---------------ITVEAEGASSSAALRVREAPVLFKKKLEPQTVEERSS 2004
Query: 2742 ETLDLNCVVPGQAHAQVTWHKR------GGSLPSHHQTRGSRLRLHHVSPADSGEYVCRV 2795
TL++ P ++ W + G ++ H + RL LH+V AD G + C
Sbjct: 2005 VTLEVELTRP---WPELRWTRNATALAPGKNVEIHAEGARHRLVLHNVGFADRGFFGCET 2061
Query: 2796 MGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAH 2855
+ +T+E V G + + E Q +H
Sbjct: 2062 PDD----KTQAKLTVEMRQVRLVR-----GLQAVEAREQGTATMEVQL----------SH 2102
Query: 2856 AQV--TWHKRGGNL---PARH-QVHGPL--LRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
A V +W + G P H V GP+ L L+ + P DSG V + G ++ L
Sbjct: 2103 ADVDGSWTRDGLRFQQGPTCHLAVRGPMHTLTLSGLRPEDSG---LMVFKAEGVHTSARL 2159
Query: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPA 2967
V E +P ++P+ TE + + L C + + + V W K G L A
Sbjct: 2160 VVTE------LPV-SFSRPL----QDVVTTEKEKVTLECEL-SRPNVDVRWLKDGVELRA 2207
Query: 2968 ------RHQTHGSQLRLHLVSPADSGEYVCRA----ASGPGPEQEASFTVT--------- 3008
Q L ++ AD G YVC A +S Q ++T+
Sbjct: 2208 GKTMAIAAQGACRSLTIYRCEFADQGVYVCDAHDAQSSASVKVQGRTYTLIYRRVLAEDA 2267
Query: 3009 -----VPPSEGSSYRLR---SPVISIDPPSSTV-QQGQDASFKCLIHDGAAPISLEWKTR 3059
V + S +LR PV + P + + +C + +A + W
Sbjct: 2268 GEIQFVAENAESRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQV--RWFKG 2325
Query: 3060 NQELE--DNVHISPNGSI--ITIVGTRPSNHGTYRCVASNAYGVAQSVVN----LSVHGP 3111
+QEL+ + +G + I + TY C A + AQ V V G
Sbjct: 2326 SQELQPGPKYELVSDGLYRKLIISDVHAEDEDTYTCDAGDVKTSAQFFVEEQSITIVRGL 2385
Query: 3112 PTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQ 3171
V+V+ P W EC ++ +W + GL V +
Sbjct: 2386 QDVTVMEPAPAW--------FECETSIPSVRPPKW--LLGKTVLQAGGNVGLEQEGTVHR 2435
Query: 3172 ISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATL 3231
+ + T +G ++ ++V + P EL + L
Sbjct: 2436 LMLRR--TCSTMTGPVHFTVGKSRSSARLVVSDIPVVLTRPLEPKTGREL-----QSVVL 2488
Query: 3232 RCSATGSPAPTIHWSKLRSPL----PWQHRLEGD--TLIIPRVAQQDSGQYICNATSPAG 3285
C +P + W K +PL ++ LEG L I R+ D+G Y C A S
Sbjct: 2489 SCDFRPAP-KAVQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRCQAGSAHS 2547
Query: 3286 HAEATIILHVESPPYATTVP-EHASVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPGRA 3343
E T VE+ T P + A C L+H + +WS G +P
Sbjct: 2548 STEVT----VEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEV--EWSLNG--MPLYN 2599
Query: 3344 TARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTP--T 3401
+ +E+ H GR V + A+A G + A+S+ ++
Sbjct: 2600 DSFHEISH--------KGRRHTLVLKSIQRADA----------GIVRASSLKVSTSARLE 2641
Query: 3402 VQVTPQLETKSIG-------ASVEFHCAVPSDRGTQLRWFKEGGQLPPG------HSVQD 3448
V+V P + K++ ++ C V SD + W K+G QL P H+
Sbjct: 2642 VRVKPVVFLKALDDLSAEERGTLALQCEV-SDPEAHVVWRKDGVQLGPSDKYDFLHTAGT 2700
Query: 3449 GVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEF 3508
L + ++ G Y C G + A++ + L V I R V+ G + F
Sbjct: 2701 RGLVVHDVSPEDAGLYTCHV----GSEETRARVRVHDL-HVGITKRLKTMEVLEGESCSF 2755
Query: 3509 ECL----ALGDPKPQVTWSK-VGGHLRPGIVQSGG--VVRIAHVELADAGQYRCTATNAA 3561
EC+ + DP K VG R + G ++ + +DAG+ +
Sbjct: 2756 ECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAGE---VVFSVR 2812
Query: 3562 GTTQSHVLLLVQALPQISMPQEVR-VPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR 3620
G T L++ + I P E + V G C S TP + W K ++ +
Sbjct: 2813 GLTSKASLIVRERPAAIIKPLEDQWVAPGEDVELRCELSRAGTP-VHWLKDRKAIRKSQK 2871
Query: 3621 LE------NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPER 3661
+ ML++ +DAG Y C K+ A L V E+
Sbjct: 2872 YDVVCEGTMAMLVIRGASLKDAGEYTCEVE----ASKSTASLHVEEK 2914
Score = 181 bits (458), Expect = 2e-44
Identities = 402/1687 (23%), Positives = 616/1687 (36%), Gaps = 314/1687 (18%)
Query: 2064 EGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGS------RLRLPQVSPADSGEYVC 2117
E Q++ L+C + A V WY+ L P + S LR+ ++ PAD+G Y C
Sbjct: 2482 ELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLMPADAGVYRC 2540
Query: 2118 RVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPG 2177
+ GS +TV T +GP SH E LN G
Sbjct: 2541 QA--GSAHSSTEVTVEAREVTVTGPLQDAEATEEGWASFSCELSHEDEEVEWSLN----G 2594
Query: 2178 QAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEA 2237
++H+ H+ L L + AD+G + + L+ S +E
Sbjct: 2595 MPLYNDSFHE------ISHKGRRHTLVLKSIQRADAG------IVRASSLKVSTSARLEV 2642
Query: 2238 SVIPGPIPPVRIESSSSTVAEGQ-TLDLSCVVAGQAHAQVTWYKRGGSLPAR------HQ 2290
V P V +++ AE + TL L C V+ A V W K G L H
Sbjct: 2643 RV----KPVVFLKALDDLSAEERGTLALQCEVS-DPEAHVVWRKDGVQLGPSDKYDFLHT 2697
Query: 2291 VRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSS 2350
L + SP DAG Y C + E V V G T+ ++ +
Sbjct: 2698 AGTRGLVVHDVSPEDAGLYTCHVGS-EETRARVRVHDLH-------VGITKRLK----TM 2745
Query: 2351 QVAEGQTLDLNCVVPGQSHAQVTWHKRGGS-------LPVRHQTHGSLLRLYQASPADSG 2403
+V EG++ CV+ +S + GG Q +L + +A+P+D+G
Sbjct: 2746 EVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYILVVREAAPSDAG 2805
Query: 2404 EYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQ 2463
E V V G + +AS++V PA + L VA G+ ++L C ++ +
Sbjct: 2806 EVVFSVRG--LTSKASLIVRERPAAIIKPL----------EDQWVAPGEDVELRCELS-R 2852
Query: 2464 AHAQVTWHKRGGSLPARHQ---VHGSRLRLLQVTPA---DSGEYVCRVVGSSGTQEASVL 2517
A V W K ++ + V + +L + A D+GEY C V S T
Sbjct: 2853 AGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEVEASKST------ 2906
Query: 2518 VTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYK-------R 2570
+ H + A E ++ + T C A T+TW K
Sbjct: 2907 -------ASLHVEEKANCFTEELTNLQVEEKGTAVFTCKTEHPAA-TVTWRKGLLELRAS 2958
Query: 2571 GGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSP 2630
G PS+ + RL I + ADS Y C + G ++ + +QG + +
Sbjct: 2959 GKHQPSQEGLT-LRLTISALEKADSDTYTCDI----GQAQSRAQLLVQGRRVHIIEDL-- 3011
Query: 2631 PIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH------QTHGSH-LRL 2683
V EG + C ++ + W+ L + Q G H L L
Sbjct: 3012 ------EDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANELNEIDAQPGGYHVLTL 3065
Query: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743
Q+++ DSG A + A++ ++ PS S E + + + EGE
Sbjct: 3066 RQLALKDSGTIYFEAGD--QRASAALRVTEKPSVFSR-----------ELTDATITEGED 3112
Query: 2744 LDLNCVVPGQAHAQVTWHKRGGSLPS------HHQTRGSRLRLHHVSPADSGEYVCRVMG 2797
L L C V W K G +L H+ ++L + + DSG Y C G
Sbjct: 3113 LTLVCET-STCDIPVCWTKDGKTLRGSARCQLSHEGHRAQLLITGATLQDSGRYKCEAGG 3171
Query: 2798 SSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPS--SSRVAEGQTLDLKCVVPGQAH 2855
A SS V V A P+R + + V EG L+CV+ A
Sbjct: 3172 --------------ACSSSIVRV----HARPVRFQEALKDLEVLEGGAATLRCVLSSVA- 3212
Query: 2856 AQVTW-----HKRGGNLPARHQVHGPLLRL--NQVSPADSGEYSCQVTGSSGTLEASVLV 2908
A V W R G+ + Q G +L L + P DSG YSC T A++ V
Sbjct: 3213 APVKWCYGNNVLRPGDKYSLRQ-EGAMLELVVRNLRPQDSGRYSCSF--GDQTTSATLTV 3269
Query: 2909 TIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLP-- 2966
T P+ + + TEG T L C + A V W K +L
Sbjct: 3270 TALPAQ------------FIGKLRNKEATEGATATLRCEL--SKAAPVEWRKGSETLRDG 3315
Query: 2967 ----ARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSY-RLRS 3021
R +L++ ++ D+ EY C E+ S ++T+ P RLR
Sbjct: 3316 DRYCLRQDGAMCELQIRGLAMVDAAEYSCVCG-----EERTSASLTIRPMPAHFIGRLR- 3369
Query: 3022 PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH--ISPNGSI--IT 3077
+G A+ +C + AAP+ EW+ + L D + +G++ +
Sbjct: 3370 --------HQESIEGATATLRCEL-SKAAPV--EWRKGRESLRDGDRHSLRQDGAVCELQ 3418
Query: 3078 IVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSA 3137
I G ++ G Y CV G ++ L+V P + EG L A
Sbjct: 3419 ICGLAVADAGEYSCVC----GEERTSATLTVKALP--AKFTEG-----------LRNEEA 3461
Query: 3138 GEPRSSARWTRISS-TPAKLEQRTYGLMD----------SHAVLQISSAKPSDAGTYVCL 3186
E ++ W +S P + + L D + LQI +DAG Y+C+
Sbjct: 3462 VEGATAMLWCELSKVAPVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCV 3521
Query: 3187 AQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWS 3246
+A + + A V+ +EA G TA L+C S AP + W
Sbjct: 3522 CGQERTSATLTIRAL-----PARFIEDVKNQEA----REGATAVLQCE-LNSAAP-VEWR 3570
Query: 3247 K----LRSPLPWQHRLEGD--TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPY 3300
K LR + R +G L I +A D+G+Y C G + +L V + P
Sbjct: 3571 KGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSC----VCGQERTSAMLTVRALPI 3626
Query: 3301 ATTVP-EHASVQAGETVQLQCLAHGTPPLTF----QWSRVGSSLPGRATARNELLHFERA 3355
T + G T L+C P+ + + R G R L
Sbjct: 3627 KFTEGLRNEEATEGATAVLRCELSKMAPVEWWKGHETLRDGDRHSLRQDGARCELQIRGL 3686
Query: 3356 APEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGA 3415
ED+G Y C G A L V+ ++P+ I + E + G
Sbjct: 3687 VAEDAGEYLC----MCGKERTSAMLTVR----AMPSKFIEG---------LRNEEATEGD 3729
Query: 3416 SVEFHCAVPSDRGTQLRWFKEGGQLPPG--HSV-QDG---VLRIQNLDQSCQGTYICQAH 3469
+ C + + + W K L G HS+ QDG L+I+ L G Y C
Sbjct: 3730 TATLWCEL--SKAAPVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAGEYSCVC- 3786
Query: 3470 GPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHL 3529
G+ + SA L ++ALP+ I Q G +C L P V W K L
Sbjct: 3787 ---GQERTSATLTVRALPARFIE-DVKNQEAREGATAVLQC-ELSKAAP-VEWRKGSETL 3840
Query: 3530 RPG----IVQSGG--VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQA-LPQISMP- 3581
R G + Q G ++I + +AD G+Y C G ++ L V+A P P
Sbjct: 3841 RGGDRYSLRQDGTRCELQIHGLSVADTGEYSC----VCGQERTSATLTVRAPQPVFREPL 3896
Query: 3582 QEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNM------LMLPSVRPQD 3635
Q ++ GS A C S PT + WSK L + R E + L+L ++ +D
Sbjct: 3897 QSLQAEEGSTATLQCELS-EPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQRED 3955
Query: 3636 AGTYVCT 3642
G Y CT
Sbjct: 3956 TGEYTCT 3962
Score = 164 bits (414), Expect = 2e-39
Identities = 482/2122 (22%), Positives = 739/2122 (34%), Gaps = 411/2122 (19%)
Query: 1686 SIVPQGGSHSL---RCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSE--LHFPSVQPSD 1740
+I QG SL RC+ + + D S + QG L + V D
Sbjct: 2212 AIAAQGACRSLTIYRCEFADQGVYVC-----DAHDAQSSASVKVQGRTYTLIYRRVLAED 2266
Query: 1741 AGVYICTCRNLHQSNTSRAELLVTEAPS---KPIT--VTVEEQRS----QSVRPGADVTF 1791
AG N SRA+L V E P +P+ + +E+ R Q R A V +
Sbjct: 2267 AGEIQFVAENAE----SRAQLRVKELPVTLVRPLRDKIAMEKHRGVLECQVSRASAQVRW 2322
Query: 1792 ICTAKSKSPA--YTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMD 1849
++ P Y LV L+ L I +V D TY C D
Sbjct: 2323 FKGSQELQPGPKYELVSDGLYRK------------LIISDVHAEDEDTYTC--------D 2362
Query: 1850 QGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP-----G 1904
G Q + + +TV A F C + +W G G
Sbjct: 2363 AGDVKTSAQFFVEEQSITIVRGLQDVTVMEPAPAWFECETSIPSVRPPKWLLGKTVLQAG 2422
Query: 1905 GQ--LPAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSP 1962
G L + +H +LR T + S+ + V + P V P
Sbjct: 2423 GNVGLEQEGTVHRLMLRRTCSTMTGPVHFTVGKSRSSARLVVSDI--------PVVLTRP 2474
Query: 1963 ERTQVHAGR---TVRLYCRAAGVPSATITWRKEGGSLPPQARSERT---DIATLLIPAIT 2016
+ GR +V L C P A + W K+ L P + + + +A L I +
Sbjct: 2475 --LEPKTGRELQSVVLSCDFRPAPKA-VQWYKDDTPLSPSEKFKMSLEGQMAELRILRLM 2531
Query: 2017 TADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAG 2076
ADAG Y C AG+A + +V V + P++ TE +C ++
Sbjct: 2532 PADAGVYRC----QAGSAHSSTEVTVEAREVTVTGPLQ----DAEATEEGWASFSCELSH 2583
Query: 2077 SAHAQVTWYRRGGSLPP---HTQVHGSR---LRLPQVSPADSGEYVCRVENGSGPKEASI 2130
+V W G L H H R L L + AD+G + R + A +
Sbjct: 2584 EDE-EVEWSLNGMPLYNDSFHEISHKGRRHTLVLKSIQRADAG--IVRASSLKVSTSARL 2640
Query: 2131 TVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA--EGQTLDLNCVVPGQAHAQVTWHKR 2188
V V +P+ + ++ E TL L C V A V W K
Sbjct: 2641 EVRV-----------------KPVVFLKALDDLSAEERGTLALQCEV-SDPEAHVVWRKD 2682
Query: 2189 GGSLPAR------HQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPG 2242
G L H L +H V+P D+G Y CHV G E V + +
Sbjct: 2683 GVQLGPSDKYDFLHTAGTRGLVVHDVSPEDAGLYTCHV----GSEETRARVRVHDLHV-- 2736
Query: 2243 PIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS-------LPARHQVRGSR 2295
+ + V EG++ CV++ ++ + + GG A Q R
Sbjct: 2737 ---GITKRLKTMEVLEGESCSFECVLSHESASDPAMWTVGGKTVGSSSRFQATRQGRKYI 2793
Query: 2296 LYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEG 2355
L + +A+P+DAG+ V + G+ + ++ V PA +P+ VA G
Sbjct: 2794 LVVREAAPSDAGEVVF-SVRGLTSKASLIVR-------ERPAAIIKPL----EDQWVAPG 2841
Query: 2356 QTLDLNCVVPGQSHAQVTWHK------RGGSLPVRHQTHGSLLRLYQASPADSGEYVCRV 2409
+ ++L C + ++ V W K + V + ++L + AS D+GEY C V
Sbjct: 2842 EDVELRCEL-SRAGTPVHWLKDRKAIRKSQKYDVVCEGTMAMLVIRGASLKDAGEYTCEV 2900
Query: 2410 LGSSVPLEASVLVTIEPAGSVPALGVTPTVRI---ESSSSQVAEGQTLDLNCLVAGQAHA 2466
E + S +L V E ++ QV E T C A A
Sbjct: 2901 ---------------EASKSTASLHVEEKANCFTEELTNLQVEEKGTAVFTCKTEHPA-A 2944
Query: 2467 QVTWHKRGGSLPA--RHQVHGS----RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI 2520
VTW K L A +HQ RL + + ADS Y C + A +LV
Sbjct: 2945 TVTWRKGLLELRASGKHQPSQEGLTLRLTISALEKADSDTYTCDI--GQAQSRAQLLV-- 3000
Query: 2521 QQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSL------ 2574
QG + + + G + C ++ + W+ L
Sbjct: 3001 ---------QGRRVHIIEDLEDVDVQEGSSATFRCRISPANYEPVHWFLDKTPLHANELN 3051
Query: 2575 -----PSRHQIVGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVS 2629
P + + L + Q+ DSG + AG + S + + + PSV
Sbjct: 3052 EIDAQPGGYHV----LTLRQLALKDSGT----IYFEAGDQRASAALRV-----TEKPSV- 3097
Query: 2630 PPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPS------RHQTHGSHLRL 2683
E + T+ EG+ L L C + + W K G +L H+ H + L +
Sbjct: 3098 --FSRELTDATITEGEDLTLVCETS-TCDIPVCWTKDGKTLRGSARCQLSHEGHRAQLLI 3154
Query: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESS--SSHVAEG 2741
++ DSG Y C A A +SIV + P+R + + V EG
Sbjct: 3155 TGATLQDSGRYKCEAGG---ACSSSIV------------RVHARPVRFQEALKDLEVLEG 3199
Query: 2742 ETLDLNCVVPGQAHAQVTW-----HKRGGSLPSHHQTRGSRLRL--HHVSPADSGEYVCR 2794
L CV+ A A V W R G S Q G+ L L ++ P DSG Y C
Sbjct: 3200 GAATLRCVLSSVA-APVKWCYGNNVLRPGDKYSLRQ-EGAMLELVVRNLRPQDSGRYSC- 3256
Query: 2795 VMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQA 2854
S G S +T+ A + + + + EG T L+C +
Sbjct: 3257 ---SFGDQTTSATLTVTALPAQFIG------------KLRNKEATEGATATLRCEL--SK 3299
Query: 2855 HAQVTWHK-----RGGNLPARHQVHGPL--LRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
A V W K R G+ Q G + L++ ++ D+ EYSC V G T S
Sbjct: 3300 AAPVEWRKGSETLRDGDRYCLRQ-DGAMCELQIRGLAMVDAAEYSC-VCGEERT---SAS 3354
Query: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL-- 2965
+TI P+PA + + + E+ EG T L C + A V W K SL
Sbjct: 3355 LTIR-----PMPAHFIGRLRHQES-----IEGATATLRCEL--SKAAPVEWRKGRESLRD 3402
Query: 2966 ----PARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV---PPSEGSSYR 3018
R +L++ ++ AD+GEY C E+ S T+TV P R
Sbjct: 3403 GDRHSLRQDGAVCELQICGLAVADAGEYSCVCG-----EERTSATLTVKALPAKFTEGLR 3457
Query: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN----VHISPNGS 3074
V +G A C + AP+ EW+ + L D +
Sbjct: 3458 NEEAV-----------EGATAMLWCEL-SKVAPV--EWRKGPENLRDGDRYILRQEGTRC 3503
Query: 3075 IITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC 3134
+ I G ++ G Y CV G ++ L++ P + + G L+C
Sbjct: 3504 ELQICGLAMADAGEYLCVC----GQERTSATLTIRALPARFIEDVKNQEAREGATAVLQC 3559
Query: 3135 -VSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT 3193
+++ P W + S T ++ + + LQI +D G Y C+ +
Sbjct: 3560 ELNSAAP---VEWRKGSETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVCGQERTS 3616
Query: 3194 AQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL- 3252
A V + G +A E G TA LRC S + W K L
Sbjct: 3617 AMLTVRAL--PIKFTEGLRNEEATE-------GATAVLRCEL--SKMAPVEWWKGHETLR 3665
Query: 3253 -PWQHRLEGD----TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP-E 3306
+H L D L I + +D+G+Y+C G + +L V + P
Sbjct: 3666 DGDRHSLRQDGARCELQIRGLVAEDAGEYLC----MCGKERTSAMLTVRAMPSKFIEGLR 3721
Query: 3307 HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNEL--------LHFERAAPE 3358
+ G+T L C P+ +W + +L R R+ L L A
Sbjct: 3722 NEEATEGDTATLWCELSKAAPV--EWRKGHETL--RDGDRHSLRQDGSRCELQIRGLAVV 3777
Query: 3359 DSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVE 3418
D+G Y C + SA +L ++PA V+ E GA+
Sbjct: 3778 DAGEYSCVCGQERTSA-------------TLTVRALPARFIEDVKNQEARE----GATAV 3820
Query: 3419 FHCAVPSDRGTQLRWFKEGGQLPPGHSV---QDGV---LRIQNLDQSCQGTYICQAHGPW 3472
C + + + W K L G QDG L+I L + G Y C
Sbjct: 3821 LQCEL--SKAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSCVC---- 3874
Query: 3473 GKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVG------ 3526
G+ + SA L ++A V S+Q G +C L +P V WSK G
Sbjct: 3875 GQERTSATLTVRAPQPVFREPLQSLQ-AEEGSTATLQC-ELSEPTATVVWSKGGLQLQAN 3932
Query: 3527 GHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ--ISMPQEV 3584
G P + + + ++ D G+Y CT G+ + L V A P + Q
Sbjct: 3933 GRREPRLQGCTAELVLQDLQREDTGEYTCT----CGSQATSATLTVTAAPVRFLRELQHQ 3988
Query: 3585 RVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENNM------LMLPSVRPQDAGT 3638
V G A C S + W K L P ++ + L++ V +DAG
Sbjct: 3989 EVDEGGTAHLCCELS-RAGASVEWRKGSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGD 4047
Query: 3639 YVCTATNRQGKVKAFAHLQVPE 3660
Y C + Q + P+
Sbjct: 4048 YTCDTGHTQSMASLSVRVPRPK 4069
Score = 153 bits (387), Expect = 3e-36
Identities = 451/1995 (22%), Positives = 706/1995 (35%), Gaps = 424/1995 (21%)
Query: 1825 LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVS-IHPPQLTVQPGQLA 1883
L +RN++ D+G Y C+ F +ATL V A L A + + + T G A
Sbjct: 3241 LVVRNLRPQDSGRYSCS----FGDQTTSATLTVTA---LPAQFIGKLRNKEAT--EGATA 3291
Query: 1884 EFRCSATGSPTPTLEWTGGP-----GGQLPAKAQIHGGILRLPAVEPTDQAQYLCRAHSS 1938
RC S +EW G G + + L++ + D A+Y C
Sbjct: 3292 TLRCEL--SKAAPVEWRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSC----V 3345
Query: 1939 AGQQVARAVLHV-----HGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEG 1993
G++ A L + H G R Q S E G T L C + +A + WRK
Sbjct: 3346 CGEERTSASLTIRPMPAHFIGRLRHQESIE------GATATLRCELS--KAAPVEWRKGR 3397
Query: 1994 GSLPPQAR-SERTD--IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASP 2050
SL R S R D + L I + ADAG Y CV +A ++ +
Sbjct: 3398 ESLRDGDRHSLRQDGAVCELQICGLAVADAGEYSCVCGEERTSATLTVKAL--------- 3448
Query: 2051 PPVKIESS--SPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----HGSR--L 2102
P K + EG T L C + S A V W + +L + G+R L
Sbjct: 3449 -PAKFTEGLRNEEAVEGATAMLWCEL--SKVAPVEWRKGPENLRDGDRYILRQEGTRCEL 3505
Query: 2103 RLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRI--EPSS 2160
++ ++ AD+GEY+C G A++T+ L P R + +
Sbjct: 3506 QICGLAMADAGEYLCVC--GQERTSATLTIRAL-----------------PARFIEDVKN 3546
Query: 2161 SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQTHGSL--------LRLHQVTPAD 2212
EG T L C + + A V W K GS R SL L++ + AD
Sbjct: 3547 QEAREGATAVLQCEL--NSAAPVEWRK--GSETLRDGDRYSLRQDGTKCELQIRGLAMAD 3602
Query: 2213 SGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESS--SSTVAEGQTLDLSCVVAG 2270
+GEY C G S ++T+ A P++ + EG T L C ++
Sbjct: 3603 TGEYSC----VCGQERTSAMLTVRAL-------PIKFTEGLRNEEATEGATAVLRCELSK 3651
Query: 2271 QAHAQVTWYKRGGSLPA--RHQVR--GSR--LYIFQASPADAGQYVCRASNGMEASITVT 2324
A V W+K +L RH +R G+R L I DAG+Y+C S +T
Sbjct: 3652 MA--PVEWWKGHETLRDGDRHSLRQDGARCELQIRGLVAEDAGEYLCMCGKE-RTSAMLT 3708
Query: 2325 VTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL--- 2381
V A P+ + +R E + EG T L C + A V W K +L
Sbjct: 3709 VR-------AMPSKFIEGLRNE----EATEGDTATLWCEL--SKAAPVEWRKGHETLRDG 3755
Query: 2382 ---PVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPT 2438
+R L++ + D+GEY C V G S +T+ P
Sbjct: 3756 DRHSLRQDGSRCELQIRGLAVVDAGEYSC-VCGQE---RTSATLTVR---------ALPA 3802
Query: 2439 VRIESSSSQVA-EGQTLDLNCLVAGQAHAQVTWHK-----RGGSLPARHQVHGSR--LRL 2490
IE +Q A EG T L C ++ A V W K RGG + Q G+R L++
Sbjct: 3803 RFIEDVKNQEAREGATAVLQCELSKAA--PVEWRKGSETLRGGDRYSLRQ-DGTRCELQI 3859
Query: 2491 LQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPV-RIESSSASLANGH 2549
++ AD+GEY C V Q+R S + + PV R S G
Sbjct: 3860 HGLSVADTGEYSC--------------VCGQERTSATLTVRAPQPVFREPLQSLQAEEGS 3905
Query: 2550 TLDLNCLVASQAPHTITWYKRG------GSLPSRHQIVGSRLRIPQVTPADSGEYVCHVS 2603
T L C + S+ T+ W K G G R Q + L + + D+GEY C
Sbjct: 3906 TATLQCEL-SEPTATVVWSKGGLQLQANGRREPRLQGCTAELVLQDLQREDTGEYTCT-- 3962
Query: 2604 NGAGSRETSLIVTIQGSGSSHVPSVSPPIRI--ESSSPTVVEGQTLDLNCVVARQPQAII 2661
GS+ TS +T+ + P+R E V EG T L C ++R A +
Sbjct: 3963 --CGSQATSATLTVTAA----------PVRFLRELQHQEVDEGGTAHLCCELSRAG-ASV 4009
Query: 2662 TWYKRGGSLP----SRHQT----HGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISV 2713
W K GSL +++Q + L + + D+G+Y C + S+ +
Sbjct: 4010 EWRK--GSLQLFPCAKYQMVQDGAAAELLVRGVEQEDAGDYTCDTGHTQSMASLSVRV-- 4065
Query: 2714 SPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVP-GQAHAQVTWHKRGGSLPS--- 2769
P R++S G+ L C + ++ A V W K G L +
Sbjct: 4066 ---------PRPKFKTRLQSLEQET--GDIARLCCQLSDAESGAVVQWLKEGVELHAGPK 4114
Query: 2770 ---HHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGA 2826
Q L +H + D+GEY C G AS+ VT
Sbjct: 4115 YEMRSQGATRELLIHQLEAKDTGEYACVTGGQK--TAASLRVT----------------E 4156
Query: 2827 PPIRIEPS--SSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARH---------QVHG 2875
P + I + V + ++ C V V W +G L + ++H
Sbjct: 4157 PEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGVQWCLQGLPLQSNEVTEVAVRDGRIH- 4215
Query: 2876 PLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSH 2935
LRL V+P D+G S + + + + +V P + +P+
Sbjct: 4216 -TLRLKGVTPEDAGTVSFHLGNHASSAQLTVRA----------PEVTILEPL----QDVQ 4260
Query: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ-------LRLHLVSPADSGE 2988
++EGQ C + + + W G L A + L LH V+ D+G
Sbjct: 4261 LSEGQDASFQCRLSRASGQEARWALGGVPLQANEMNDITVEQGTLHLLTLHKVTLEDAGT 4320
Query: 2989 YVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDG 3048
SF V SE + + +G +A F+C +
Sbjct: 4321 --------------VSFHVGTCSSEAQLKVTAKNTVVRGLENVEALEGGEALFECQLSQP 4366
Query: 3049 AAPISLEWKTRNQELEDN-VHISPNGSII----------TIVGTRPSNHGTYRCVASNAY 3097
E L+D VH S N ++ + RP + C +
Sbjct: 4367 ------EVAAHTWLLDDEPVHTSENAEVVFFENGLRHLLLLKNLRPQDS----CRVTFLA 4416
Query: 3098 GVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLEC-VSAGEPRSSARWTRISSTPAKL 3156
G + L+V G + P V+ G C +S P A W I+ +
Sbjct: 4417 GDMVTSAFLTVRGWRLEILEPLKNAAVRAGAQACFTCTLSEAVPVGEASWY-INGAAVQP 4475
Query: 3157 EQRTYGLM--DSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV 3214
+ + + SH L + SA+P AG ++A+ +A+ V + D
Sbjct: 4476 DDSDWTVTADGSHHALLLRSAQPHHAGEVTFACRDAVASARLTVLGLPD----------- 4524
Query: 3215 QAEEAELTVEAGHTATLRCSA---TGSPAPTIHWSKLRSPLPWQHRL-----EGDTLIIP 3266
E+AE+ + HT TL +A G + +++ Q RL G ++
Sbjct: 4525 PPEDAEVVARSSHTVTLSWAAPMSDGGGGLCGYRVEVKEGATGQWRLCHELVPGPECVVD 4584
Query: 3267 RVAQQDSGQYICNATSPAG-----HAEATIILHVESP---PYATTVPEHASVQAGETVQL 3318
+A ++ ++ A P G H T+ L E P P + PE V AGE V L
Sbjct: 4585 GLAPGETYRFRVAAVGPVGAGEPVHLPQTVRL-AEPPKPVPPQPSAPESRQVAAGEDVSL 4643
Query: 3319 QCLAHGTPPLTFQWSRVGSSLPGR-----ATARNELLHFERAAPEDSGRYRCRVT-NKVG 3372
+ + PG + R ++L + ED G Y C + +
Sbjct: 4644 ELEVVAEAGEVIWHKGMERIQPGGRFEVVSQGRQQMLVIKGFTAEDQGEYHCGLAQGSIC 4703
Query: 3373 SAEAFAQLLV------QGPPGSLPATSIPAGSTPTV-QVTPQLETKSIGASVEFHCAVPS 3425
A A Q+ + + P SLP + G + + + S +++ +P
Sbjct: 4704 PAAATFQVALSPASVDEAPQPSLPPEAAQEGDLHLLWEALARKRRMSREPTLDSISELPE 4763
Query: 3426 DRGTQLRWFKEGGQLPP----GHSVQDGVLRIQNLDQSCQG-------------TYICQA 3468
+ G R +E ++ P G+S D + R + D S TY+ +A
Sbjct: 4764 EDGRSQRLPQEAEEVAPDLSEGYSTADELARTGDADLSHTSSDDESRAGTPSLVTYLKKA 4823
Query: 3469 HGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKV--- 3525
P G + ++++ A PSV + V + LGDP K+
Sbjct: 4824 GRP-GTSPLASKVGAPAAPSVKPQQQQEPLAAVRPPLGDLSTKDLGDPSMDKAAVKIQAA 4882
Query: 3526 --GGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQE 3583
G +R + Q G + ++ G T++ V
Sbjct: 4883 FKGYKVRKEMKQQEGPM----------------FSHTFGDTEAQV--------------- 4911
Query: 3584 VRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLEN--------NMLMLPSVRPQD 3635
G A C+ + W K DG D R + L++ + D
Sbjct: 4912 -----GDALRLECVVASKADVRARWLK-DGVELTDGRHHHIDQLGDGTCSLLITGLDRAD 4965
Query: 3636 AGTYVCTATNRQGKV 3650
AG Y C +N+ G+V
Sbjct: 4966 AGCYTCQVSNKFGQV 4980
Score = 147 bits (370), Expect = 3e-34
Identities = 331/1307 (25%), Positives = 490/1307 (37%), Gaps = 250/1307 (19%)
Query: 1688 VPQGGSHSLRCQVSG--SPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYI 1745
V +GG+ +LRC +S +P + Y + +Q EL +++P D+G Y
Sbjct: 3196 VLEGGAATLRCVLSSVAAPVKWCYGNNVLRPGDKYSLRQEGAMLELVVRNLRPQDSGRYS 3255
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
C+ + T+ A L VT P++ + + R++ GA T C +P +
Sbjct: 3256 CSFGD----QTTSATLTVTALPAQ----FIGKLRNKEATEGATATLRCELSKAAP---VE 3304
Query: 1806 WTR----LHNGKLPTRAMDFNGI-LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQAS 1860
W + L +G D L IR + + DA Y C ++ +A+L ++
Sbjct: 3305 WRKGSETLRDGDRYCLRQDGAMCELQIRGLAMVDAAEYSCVCGE----ERTSASLTIRP- 3359
Query: 1861 GTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP----GGQLPAKAQIHGG 1916
+ A + Q +++ G A RC S +EW G G + Q G
Sbjct: 3360 --MPAHFIGRLRHQESIE-GATATLRCEL--SKAAPVEWRKGRESLRDGDRHSLRQ-DGA 3413
Query: 1917 I--LRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVR 1974
+ L++ + D +Y C G++ A L V + V G T
Sbjct: 3414 VCELQICGLAVADAGEYSC----VCGEERTSATLTVKALPAKFTEGLRNEEAVE-GATAM 3468
Query: 1975 LYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT---LLIPAITTADAGFYLCVATSPA 2031
L+C + V A + WRK +L R T L I + ADAG YLCV
Sbjct: 3469 LWCELSKV--APVEWRKGPENLRDGDRYILRQEGTRCELQICGLAMADAGEYLCVCGQER 3526
Query: 2032 GTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL 2091
+A I+ A P + + EG T L C + ++ A V W R GS
Sbjct: 3527 TSATLTIR--------ALPARFIEDVKNQEAREGATAVLQCEL--NSAAPVEW--RKGS- 3573
Query: 2092 PPHTQVHGSRLRLPQ-----------VSPADSGEYVCRVENGSGPKEASITVSVLHGTHS 2140
T G R L Q ++ AD+GEY C G A +TV L
Sbjct: 3574 --ETLRDGDRYSLRQDGTKCELQIRGLAMADTGEYSCVC--GQERTSAMLTVRAL----- 3624
Query: 2141 GPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK-----RGGSLPAR 2195
P+ T +R E ++ EG T L C + A V W K R G +
Sbjct: 3625 -----PIK-FTEGLRNEEAT----EGATAVLRCELSKMA--PVEWWKGHETLRDGDRHSL 3672
Query: 2196 HQTHGSL-LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSS 2254
Q L++ + D+GEY+C G S ++T+ A +P IE +
Sbjct: 3673 RQDGARCELQIRGLVAEDAGEYLC----MCGKERTSAMLTVRA------MPSKFIEGLRN 3722
Query: 2255 TVA-EGQTLDLSCVVAGQAHAQVTWYKRGGSLPA--RHQVR--GSR--LYIFQASPADAG 2307
A EG T L C ++ A V W K +L RH +R GSR L I + DAG
Sbjct: 3723 EEATEGDTATLWCELSKAA--PVEWRKGHETLRDGDRHSLRQDGSRCELQIRGLAVVDAG 3780
Query: 2308 QYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ 2367
+Y C S T+TV A PA + ++ + + EG T L C +
Sbjct: 3781 EYSCVCGQE-RTSATLTVR-------ALPARFIEDVK----NQEAREGATAVLQCEL--S 3826
Query: 2368 SHAQVTWHK-----RGGS-LPVRHQTHGSLLRLYQASPADSGEYVCRVLGSSVPLEASVL 2421
A V W K RGG +R L+++ S AD+GEY C V G S
Sbjct: 3827 KAAPVEWRKGSETLRGGDRYSLRQDGTRCELQIHGLSVADTGEYSC-VCGQE---RTSAT 3882
Query: 2422 VTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPA-- 2479
+T+ P R S Q EG T L C ++ + A V W K G L A
Sbjct: 3883 LTVRAP--------QPVFREPLQSLQAEEGSTATLQCELS-EPTATVVWSKGGLQLQANG 3933
Query: 2480 ----RHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYP 2535
R Q + L L + D+GEY C + G+Q S +T+ A P
Sbjct: 3934 RREPRLQGCTAELVLQDLQREDTGEYTC----TCGSQATSATLTV-----------TAAP 3978
Query: 2536 VRI--ESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLP----SRHQIV----GSRL 2585
VR E + G T L C S+A ++ W K GSL +++Q+V + L
Sbjct: 3979 VRFLRELQHQEVDEGGTAHL-CCELSRAGASVEWRK--GSLQLFPCAKYQMVQDGAAAEL 4035
Query: 2586 RIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQ 2645
+ V D+G+Y C + Q S V P + S G
Sbjct: 4036 LVRGVEQEDAGDYTCDTGH------------TQSMASLSVRVPRPKFKTRLQSLEQETGD 4083
Query: 2646 TLDLNCVVA-RQPQAIITWYKRGGSLPS------RHQTHGSHLRLHQMSVADSGEYVCRA 2698
L C ++ + A++ W K G L + R Q L +HQ+ D+GEY C
Sbjct: 4084 IARLCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYAC-- 4141
Query: 2699 NNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQV 2758
V +A S + I + V E ++ +C V V
Sbjct: 4142 -----------VTGGQKTAASLRVTEPEVTIVRGLVDAEVTADEDVEFSCEVSRAGATGV 4190
Query: 2759 TWHKRGGSLPSHHQT-------RGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
W +G L S+ T R LRL V+P D+G V G +S +T+
Sbjct: 4191 QWCLQGLPLQSNEVTEVAVRDGRIHTLRLKGVTPEDAG----TVSFHLGNHASSAQLTVR 4246
Query: 2812 ASGSSAVHVPAPGGAPPIRI-EP-SSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA 2869
AP + I EP +++EGQ +C + + + W G L A
Sbjct: 4247 --------------APEVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGGVPLQA 4292
Query: 2870 R-------HQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVT 2909
Q LL L++V+ D+G S V S EA + VT
Sbjct: 4293 NEMNDITVEQGTLHLLTLHKVTLEDAGTVSFHVGTCSS--EAQLKVT 4337
Score = 133 bits (334), Expect = 4e-30
Identities = 290/1356 (21%), Positives = 471/1356 (34%), Gaps = 226/1356 (16%)
Query: 2431 PALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGS---- 2486
P P + V+ G+ L+C + G QV+W K + A + +
Sbjct: 4 PQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGD 63
Query: 2487 --RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSAS 2544
RL +L + DSG+YVCR + G A+V + + + + A + +S
Sbjct: 64 LYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQ---APHFLLRPTSIR 120
Query: 2545 LANGHTLDLNCLVASQAPHTITWYKRGGSLPS------RHQIVG--SRLRIPQVTPADSG 2596
+ G C V ++W K G L R + +G S LRI P D G
Sbjct: 121 VREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDGG 180
Query: 2597 EYVCHVSN--GAGSRETSLIVTIQGSGSSHVPSVS------------PPIRIES--SSP- 2639
Y N GA S +L+V + ++ P S +R E +SP
Sbjct: 181 TYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASPP 240
Query: 2640 -------TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSH--------LRLH 2684
TV EG+ L+C V +P+ W K+ G L + + H + L++
Sbjct: 241 STGTRTCTVTEGKHARLSCYVTGEPKPETVW-KKDGQLVTEGRRHVVYEDAQENFVLKIL 299
Query: 2685 QMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETL 2744
+D G Y C A+N + +S+++ V A +P + V E E+
Sbjct: 300 FCKQSDRGLYTCTASNLVGQTYSSVLVVVREPA---------VPFKKRLQDLEVREKESA 350
Query: 2745 DLNCVVPGQAHAQVTWHKRGGSLPS------HHQTRGSRLRLHHVSPADSGEYVCRVMGS 2798
C VP Q + W K L + + RL + +VS D Y+C
Sbjct: 351 TFLCEVP-QPSTEAAWFKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICET--- 406
Query: 2799 SGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQV 2858
P + + + G+ +R P + V G T + CV V
Sbjct: 407 --PEGSRTVAELAVQGNL------------LRKLPRKTAVRVGDTA-MFCVELAVPVGPV 451
Query: 2859 TWHKR------GGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEP 2912
W + GG + + L ++Q D G QV +G + S +
Sbjct: 452 HWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVG----QVAFMAGDCQTSTQFCVSA 507
Query: 2913 SSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGS---LPARH 2969
P+ P P+ S V + + P + K+ G+ +
Sbjct: 508 PRKPPLQPP--VDPVVKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHE 565
Query: 2970 QTHGSQLRLHLVSPADSGEYVCRAAS----GPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3025
+ L + A+ G + R ++ G P E TV + +P ++
Sbjct: 566 AEWVATPELTVADVAEEGNFQFRVSALNSFGQSPYLEFPGTVHL-----------APKLA 614
Query: 3026 IDPPSSTVQ--QGQDASFKCLIHDGAAPISLEWKTRNQELEDN----VHISPNGSIITIV 3079
+ P VQ +G + +F D + EW Q L+ + +H +TI
Sbjct: 615 VRTPLKAVQAVEGGEVTFSV---DLTVASAGEWFLDGQALKASSVYEIHCDRTRHTLTIR 671
Query: 3080 GTRPSNHGTYRCVASNAYGVAQSV-------VNLSVHGPPTVSVLPEGPVWVKVGKAVTL 3132
S HG +N G+ S+ L+ + PP + V ++ + L
Sbjct: 672 EVPASLHGAQLKFVAN--GIESSIRMEVRAAPGLTANKPPAAAA---REVLARLHEEAQL 726
Query: 3133 ECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALG 3192
+ ++ W + T + + VL + DAG Y C+++
Sbjct: 727 -LAELSDQAAAVTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRI 785
Query: 3193 TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVE--AGHTATLRCSATGSPAPTIHWSK--- 3247
Q V+ + A + + A V+ AG A C T +HW K
Sbjct: 786 AYQLSVQGL---------ARFLHKDMAGSCVDAVAGGPAQFECE-TSEAHVHVHWYKDGM 835
Query: 3248 ---------LRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESP 3298
L+ + +HRL T V +QD G Y C G L V P
Sbjct: 836 ELGHSGERFLQEDVGTRHRLVAAT-----VTRQDEGTYSCR----VGEDSVDFRLRVSEP 886
Query: 3299 PYATTVPEHA----SVQAGETVQLQC-LAHGTPPLTFQWSRVGSSLPG------RATARN 3347
+ A +AG + L C +A +T W + G L AT
Sbjct: 887 KVVFAKEQLARRKLQAEAGASATLSCEVAQAQTEVT--WYKDGKKLSSSSKVCMEATGCT 944
Query: 3348 ELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQ 3407
L ++A D+G Y C + G L V+ P QV
Sbjct: 945 RRLVVQQAGQADAGEYSC----EAGGQRLSFHLDVKEPKVVFAKD----------QVAHS 990
Query: 3408 LETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG---HSVQDGVLR---IQNLDQSCQ 3461
GAS C V + T++ W+K+G +L H G R +Q ++
Sbjct: 991 EVQAEAGASATLSCEV-AQAQTEVMWYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDA 1049
Query: 3462 GTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLA--LGDPKPQ 3519
G Y C+A G + S +L I P ++ SV V A L+ + + +
Sbjct: 1050 GDYSCEARG----QRVSFRLHITE-PKMMFAKEQSVHNEVQAEAGASAMLSCEVAQAQTE 1104
Query: 3520 VTWSKVGGHL----RPGIVQSGGVVRIA--HVELADAGQYRCTATNAAGTTQSHVLLLVQ 3573
VTW K G L + G+ G R+ ADAG+Y C A + H+
Sbjct: 1105 VTWYKDGKKLSSSSKVGMEVKGCTRRLVLPQAGKADAGEYSCEAGGQRVSFHLHITEPKG 1164
Query: 3574 AL-PQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE------NNML 3626
+ S+ EV+ AG+ A+ C + P +++W K L S++ L
Sbjct: 1165 VFAKEQSVHNEVQAEAGTTAMLSCEVA-QPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRL 1223
Query: 3627 MLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERV 3662
++ V DAG Y C A + +V H+ P+ V
Sbjct: 1224 VVQQVGKADAGEYSCEAGGQ--RVSFQLHITEPKAV 1257
Score = 105 bits (263), Expect = 8e-22
Identities = 212/933 (22%), Positives = 331/933 (35%), Gaps = 134/933 (14%)
Query: 2821 PAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA----RHQVHGP 2876
P GAP P + V+ G+ L C + G QV+W K + A R G
Sbjct: 4 PQFSGAPRFLTRPKAFVVSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGD 63
Query: 2877 LLRLN--QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSS 2934
L RL ++ DSG+Y C+ + G A+V + ++ + AP + +S
Sbjct: 64 LYRLTILDLALGDSGQYVCRARNAIGEAFAAVGLQVDAEAACAEQAP----HFLLRPTSI 119
Query: 2935 HVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL--------PARHQTHGSQLRLHLVSPADS 2986
V EG C V G V+W K G L S LR+ P D
Sbjct: 120 RVREGSEATFRCRVGGSPRPAVSWSKDGRRLGEPDGPRVRVEELGEASALRIRAARPRDG 179
Query: 2987 GEYVCRAASGPGPEQEASFTVTVPPSEGSSYR------------------LRSPVISIDP 3028
G Y RA + G A+ V + ++ R +R+ P
Sbjct: 180 GTYEVRAENPLGAASAAAALVVDSDAADTASRPGTSTAALLAHLQRRREAMRAEGAPASP 239
Query: 3029 PSS-----TVQQGQDASFKCLIHDGAAPISLEWKTRNQEL-EDNVHI----SPNGSIITI 3078
PS+ TV +G+ A C + P ++ WK Q + E H+ + ++ I
Sbjct: 240 PSTGTRTCTVTEGKHARLSCYVTGEPKPETV-WKKDGQLVTEGRRHVVYEDAQENFVLKI 298
Query: 3079 VGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAG 3138
+ + S+ G Y C ASN G S V + V P + V+ ++ T C
Sbjct: 299 LFCKQSDRGLYTCTASNLVGQTYSSVLVVVREPAVPFKKRLQDLEVREKESATFLC-EVP 357
Query: 3139 EPRSSARWTRISSTPAKLEQRTYGLMD--SHAVLQISSAKPSDAGTYVCLAQNALGTAQK 3196
+P + A W YG+ + + L + + D Y+C +
Sbjct: 358 QPSTEAAW--FKEETRLWASAKYGIEEEGTERRLTVRNVSADDDAVYICETPE----GSR 411
Query: 3197 QVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQH 3256
V + G + P+ A V G TA + C P +HW + + +
Sbjct: 412 TVAELAVQGNLLRKLPRKTA------VRVGDTA-MFCVELAVPVGPVHWLRNQEEVVAGG 464
Query: 3257 RL----EG--DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE---- 3306
R+ EG TL I + +D GQ AG + + V +P P
Sbjct: 465 RVAISAEGTRHTLTISQCCLEDVGQ----VAFMAGDCQTSTQFCVSAPRKPPLQPPVDPV 520
Query: 3307 -HASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRAT----------ARNELLHFERA 3355
A +++ + HG P+T V G T A EL + A
Sbjct: 521 VKARMESSVILSWSPPPHGERPVTIDGYLVEKKKLGTYTWIRCHEAEWVATPELTVADVA 580
Query: 3356 APEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGA 3415
+ G ++ RV+ + +F Q PG++ A TP ++ +E +
Sbjct: 581 ---EEGNFQFRVS----ALNSFGQSPYLEFPGTVHLAPKLAVRTP-LKAVQAVEGGEVTF 632
Query: 3416 SVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ------DGVLRIQNLDQSCQGTYI-CQA 3468
SV+ A + WF +G L + L I+ + S G + A
Sbjct: 633 SVDLTVASAGE------WFLDGQALKASSVYEIHCDRTRHTLTIREVPASLHGAQLKFVA 686
Query: 3469 HGPWGKAQASAQLVIQALPSVLIN--IRTSVQTVVVGHAVEFECLA-LGDPKPQVTWSKV 3525
+G ++S ++ ++A P + N + + V+ E + LA L D VTW K
Sbjct: 687 NG----IESSIRMEVRAAPGLTANKPPAAAAREVLARLHEEAQLLAELSDQAAAVTWLKD 742
Query: 3526 GGHLRPG----IVQSGG--VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQIS 3579
G L PG + S G V+ + V DAG Y C + Q V L + L +
Sbjct: 743 GRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGRIAYQLSVQGLARFLHKDM 802
Query: 3580 MPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL-------ENNMLMLPSVR 3632
V AG A F C S + W K L + L+ +V
Sbjct: 803 AGSCVDAVAGGPAQFECETSEAHV-HVHWYKDGMELGHSGERFLQEDVGTRHRLVAATVT 861
Query: 3633 PQDAGTYVCTATNRQGKVKAFAHLQVPERVVPY 3665
QD GTY C R G+ L+V E V +
Sbjct: 862 RQDEGTYSC----RVGEDSVDFRLRVSEPKVVF 890
Score = 103 bits (256), Expect = 5e-21
Identities = 119/474 (25%), Positives = 178/474 (37%), Gaps = 68/474 (14%)
Query: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQ--HRLEGD-----TLI 3264
P + E A+ T E G T L C TG+P P I W K + H L D LI
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 3265 IPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHG 3324
+ + DSGQY+C A S AG+ + V+ PP + GE Q C G
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASPFVEGEDAQFTCTIEG 6133
Query: 3325 TPPLTFQWSRVGSSLPGRATARNE------------LLHFERAAPEDSGRYRCRVTNKVG 3372
P +W + G+ L T N+ +L A+ ED G Y C + N++G
Sbjct: 6134 APYPQIRWYKDGALL----TTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLG 6189
Query: 3373 SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLR 3432
SA A A+L +Q +P +Q Q + + A+VE +D+
Sbjct: 6190 SARASAELRIQ---------------SPMLQAQEQCHREQLVAAVEDTTLERADQEVTSV 6234
Query: 3433 WFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHG--PWGKAQASAQLVIQALPSVL 3490
+ G PG S D + +G Q G P + A V +P L
Sbjct: 6235 LKRLLGPKAPGPSTGD----LTGPGPCPRGAPALQETGSQPPVTGTSEAPAVPPRVPQPL 6290
Query: 3491 INIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADA 3550
++ + + A E+ ++ G PG +G ++ H +
Sbjct: 6291 LHEGPEQEPEAIARAQEW-----------TVPIRMEGAAWPG-AGTGELLWDVHSHVVRE 6338
Query: 3551 GQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSK 3610
R A T + + Q+++ ++V+ G A F I G P P ++W K
Sbjct: 6339 TTQRTYTYQAIDTHTARPPSM-----QVTI-EDVQAQTGGTAQFEAIIEGDPQPSVTWYK 6392
Query: 3611 LDGSLPPDSRLENNM------LMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
L +RL L+L V +DAG Y C A N G+V A L V
Sbjct: 6393 DSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLV 6446
Score = 93.2 bits (230), Expect = 5e-18
Identities = 316/1508 (20%), Positives = 494/1508 (32%), Gaps = 288/1508 (19%)
Query: 1696 LRCQVSGSPPHYFYWSREDGRPVPSGT--QQRHQGS--ELHFPSVQPSDAGVYICTCRNL 1751
L CQ+S + ++G + +G + R QG+ EL ++ D G Y C
Sbjct: 4087 LCCQLSDAESGAVVQWLKEGVELHAGPKYEMRSQGATRELLIHQLEAKDTGEYACVTGG- 4145
Query: 1752 HQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHN 1811
+ A L VTE P V V DV F C S++ A + W
Sbjct: 4146 ---QKTAASLRVTE----PEVTIVRGLVDAEVTADEDVEFSCEV-SRAGATGVQWCLQG- 4196
Query: 1812 GKLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHV-----QASGTLSAP 1866
LP ++ + + V + D + + D GT + H+ A T+ AP
Sbjct: 4197 --LPLQSNE------VTEVAVRDGRIHTLRLKGVTPEDAGTVSFHLGNHASSAQLTVRAP 4248
Query: 1867 VVSIHPPQLTVQ--PGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPAVE 1924
V+I P VQ GQ A F+C + + W G +P +A + +
Sbjct: 4249 EVTILEPLQDVQLSEGQDASFQCRLSRASGQEARWALGG---VPLQAN------EMNDIT 4299
Query: 1925 PTDQAQYLCRAHSSAGQQVARAVLHVHG-GGGPRVQVSPERTQVHA--------GRTVRL 1975
+L H + HV +++V+ + T V G
Sbjct: 4300 VEQGTLHLLTLHKVTLEDAGTVSFHVGTCSSEAQLKVTAKNTVVRGLENVEALEGGEALF 4359
Query: 1976 YCRAAGVPSATITWRKEGGSLPPQARSERTDIA--------TLLIPAITTADAGFYLCVA 2027
C+ + A TW + P SE ++ LL+ + D+ C
Sbjct: 4360 ECQLSQPEVAAHTWLLDD---EPVHTSENAEVVFFENGLRHLLLLKNLRPQDS----CRV 4412
Query: 2028 TSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHA-QVTWYR 2086
T AG + V P+K + +V G C ++ + + +WY
Sbjct: 4413 TFLAGDMVTSAFLTVRGWRLEILEPLK----NAAVRAGAQACFTCTLSEAVPVGEASWYI 4468
Query: 2087 RGGSLPPHTQ-----VHGSR--LRLPQVSPADSGE--YVCRVENGSGPKEASITVSVLHG 2137
G ++ P GS L L P +GE + CR AS ++VL
Sbjct: 4469 NGAAVQPDDSDWTVTADGSHHALLLRSAQPHHAGEVTFACR------DAVASARLTVLG- 4521
Query: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL----- 2192
+P + SSH T+ L+ P GG L
Sbjct: 4522 ---------LPDPPEDAEVVARSSH-----TVTLSWAAP--------MSDGGGGLCGYRV 4559
Query: 2193 PARHQTHGSLLRLHQVTPADS--------GEYVCHVVGTSGPLEASVLV----TIEASVI 2240
+ G H++ P GE V GP+ A V T+ +
Sbjct: 4560 EVKEGATGQWRLCHELVPGPECVVDGLAPGETYRFRVAAVGPVGAGEPVHLPQTVRLAEP 4619
Query: 2241 PGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKR------GGSLPARHQVRGS 2294
P P+PP S VA G+ + L V +A +V W+K GG Q R
Sbjct: 4620 PKPVPPQPSAPESRQVAAGEDVSLELEVVAEA-GEVIWHKGMERIQPGGRFEVVSQGRQQ 4678
Query: 2295 RLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAE 2354
L I + D G+Y C + G PA +T + + P+S A
Sbjct: 4679 MLVIKGFTAEDQGEYHCGLAQGSIC----------------PAAATFQVALSPASVDEAP 4722
Query: 2355 GQTLDLNCVVPGQSHA--QVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLGS 2412
+L G H + KR S R T S+ L P + G
Sbjct: 4723 QPSLPPEAAQEGDLHLLWEALARKRRMS---REPTLDSISEL----PEEDGR------SQ 4769
Query: 2413 SVPLEASVLVT-----IEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQ 2467
+P EA + A + G S A +L AG+
Sbjct: 4770 RLPQEAEEVAPDLSEGYSTADELARTGDADLSHTSSDDESRAGTPSLVTYLKKAGRPGTS 4829
Query: 2468 VTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTI-----QQ 2522
K G + + L V P G+ + +G +A+V + +
Sbjct: 4830 PLASKVGAPAAPSVKPQQQQEPLAAVRPP-LGDLSTKDLGDPSMDKAAVKIQAAFKGYKV 4888
Query: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPS-RHQIV 2581
R +G + + A + G L L C+VAS+A W K G L RH +
Sbjct: 4889 RKEMKQQEGPMFSHTFGDTEAQV--GDALRLECVVASKADVRARWLKDGVELTDGRHHHI 4946
Query: 2582 GS------RLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPI--- 2632
L I + AD+G Y C VSN G S V + GS S S +
Sbjct: 4947 DQLGDGTCSLLITGLDRADAGCYTCQVSNKFGQVTHSACVVVSGSESEAESSSGGELDDA 5006
Query: 2633 ----------RIESSSPTVVEGQTLDLNCVVA-RQPQAIITWYKRGGSLPSRHQTHGSHL 2681
+ SP V + L L+ +P+ W R H +
Sbjct: 5007 FRRAARRLHRLFRTKSPAEVSDEELFLSADEGPAEPEEPADWQ------TYREDEHFICI 5060
Query: 2682 RLHQMSVADSGEYVCRANNNIDALEASIVIS------------VSPSAGSPSAPGSSMPI 2729
R ++ ++ + V R L + I +S +P P +P
Sbjct: 5061 RFE--ALTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPS 5118
Query: 2730 RIESSSS----------HVAEGETLDLNCVVPGQAHAQVTWHKRGGSLP-------SHHQ 2772
+ S ++ V +G + +CVV GQ V W K G L + Q
Sbjct: 5119 LLTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQ 5178
Query: 2773 TRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGS----------SAVHVPA 2822
G +L + V PAD G Y C S G + ++ + + S+ + A
Sbjct: 5179 QGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSA 5238
Query: 2823 PGGAPPIRIEPSSSRVAEGQ-------TLDLKCV-----------VPGQAHAQVTWHKRG 2864
G E + S EGQ DL+ V G ++ W K G
Sbjct: 5239 QGYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDG 5298
Query: 2865 GNLPARHQVHGP------LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE-PSSPGP 2917
L A + L + V+ DSG+Y+ ++ + G +S + + P P
Sbjct: 5299 QPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEE 5358
Query: 2918 IPAPG----LAQPIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQVTWYKR----------- 2961
PA L P +E + V +G ++ + V G+ V W +
Sbjct: 5359 KPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGP 5418
Query: 2962 ---GGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSEGSSY 3017
G ++ + Q H L L V G Y C A++ G AS V+ P
Sbjct: 5419 DTPGYTVASSAQQH--SLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLPKVEEQE 5476
Query: 3018 RLRSPVIS 3025
+++ +IS
Sbjct: 5477 KVKEALIS 5484
Score = 84.7 bits (208), Expect = 2e-15
Identities = 131/581 (22%), Positives = 197/581 (33%), Gaps = 119/581 (20%)
Query: 2741 GETLDLNCVVPGQAHAQVTWHKRGGSLPS---HHQTR----GSRLRLHHVSPADSGEYVC 2793
G+ L L CVV +A + W K G L HH + L + + AD+G Y C
Sbjct: 4912 GDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTCSLLITGLDRADAGCYTC 4971
Query: 2794 RVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRV-------AEGQTLDL 2846
+V G + S V + SGS + + GG ++ R+ + + D
Sbjct: 4972 QVSNKFGQVTHSACVVV--SGSESEAESSSGGELDDAFRRAARRLHRLFRTKSPAEVSDE 5029
Query: 2847 KCVV-----PGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGT 2901
+ + P + W R H +R ++ A Q ++
Sbjct: 5030 ELFLSADEGPAEPEEPADWQTY------REDEHFICIRFEALTEARQAVTRFQEMFATLG 5083
Query: 2902 LEASVLVT----------IEPSSPGPI----PAPGL----AQPIYI-EASSSHVTEGQTL 2942
+ + + I +P P+ P P L A P+++ E + V +G +
Sbjct: 5084 IGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSLLTSDAAPVFLTELQNQEVQDGYPV 5143
Query: 2943 DLNCVVPGQAHAQVTWYKRGGSLPA-------RHQTHGSQLRLHLVSPADSGEYVCRAAS 2995
+CVV GQ V W+K G L Q G QL + V PAD G Y C A +
Sbjct: 5144 SFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPADMGVYRCLAEN 5203
Query: 2996 GPGPEQ----------EASFTVTVPPSEGSSYRLRSPVISI---DPPSSTVQQGQD---- 3038
G + +E SSY +S + ST +GQ
Sbjct: 5204 SMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTDEGQLPQVV 5263
Query: 3039 --------------ASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIIT----IVG 3080
A F+ + AP L W Q L + HI I I+
Sbjct: 5264 EELRDLQVAPGTRLAKFQLKVKGYPAP-RLYWFKDGQPLTASAHIRMTDKKILHTLEIIS 5322
Query: 3081 TRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEG----------------PVWV 3124
+ G Y SNA G A S L V GP P P V
Sbjct: 5323 VTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRMLERFTPKKV 5382
Query: 3125 KVGKAVTLECVSAGEPRSSARWTRISSTPAKL----EQRTYGLMDS---HAVLQISSAKP 3177
K G ++T G P + W R + L + Y + S H+++ + +
Sbjct: 5383 KKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHSLVLLDVGR- 5441
Query: 3178 SDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE 3218
GTY C+A NA G A + G P+V+ +E
Sbjct: 5442 QHQGTYTCIASNAAGQA------LCSASLHVSGLPKVEEQE 5476
Score = 76.6 bits (187), Expect = 5e-13
Identities = 136/595 (22%), Positives = 203/595 (34%), Gaps = 147/595 (24%)
Query: 3022 PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH-----ISPNGSII 3076
P+ S + Q G +C++ A + W EL D H + +
Sbjct: 4898 PMFSHTFGDTEAQVGDALRLECVVAS-KADVRARWLKDGVELTDGRHHHIDQLGDGTCSL 4956
Query: 3077 TIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVS 3136
I G ++ G Y C SN +G + V G + + E S
Sbjct: 4957 LITGLDRADAGCYTCQVSNKFGQVTHSACVVVSGSESEA-----------------ESSS 4999
Query: 3137 AGE-----PRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTY------VC 3185
GE R++ R R+ T + E L S +P+D TY +C
Sbjct: 5000 GGELDDAFRRAARRLHRLFRTKSPAEVSDEELFLSADEGPAEPEEPADWQTYREDEHFIC 5059
Query: 3186 LAQNALGTAQ--------------------------KQVEVIVDTGAMAP---------- 3209
+ AL A+ ++VE+ + AP
Sbjct: 5060 IRFEALTEARQAVTRFQEMFATLGIGVEIKLVEQGPRRVEMCISKETPAPVVPPEPLPSL 5119
Query: 3210 ----GAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPW-------QHRL 3258
AP E V+ G+ + C TG P P++ W K L + +
Sbjct: 5120 LTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQ 5179
Query: 3259 EGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVE--SPPYAT-------------- 3302
G LII V D G Y C A + G + L V+ S Y T
Sbjct: 5180 GGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQ 5239
Query: 3303 -------------TVPEHASVQAGETVQLQCLAHGTPPLTFQ------------WSRVGS 3337
T E Q E ++ +A GT FQ W + G
Sbjct: 5240 GYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFKDGQ 5299
Query: 3338 SLPGRATAR---NELLH---FERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGP--PGSL 3389
L A R ++LH EDSG+Y ++N +G+A + A+LLV+GP P
Sbjct: 5300 PLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEK 5359
Query: 3390 PATSIPAGSTP---TVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEG--------G 3438
PA+ + P + TP+ K G+S+ F V + W +E G
Sbjct: 5360 PASDVHEQLVPPRMLERFTPKKVKK--GSSITFSVKVEGRPVPTVHWLREEAERGVLWIG 5417
Query: 3439 QLPPGHSV----QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSV 3489
PG++V Q L + ++ + QGTY C A G+A SA L + LP V
Sbjct: 5418 PDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSGLPKV 5472
Score = 69.3 bits (168), Expect = 8e-11
Identities = 50/177 (28%), Positives = 76/177 (42%), Gaps = 17/177 (9%)
Query: 1970 GRTVRLYCRAAGVPSATITWRKEGGSL---PPQARSERTD-IATLLIPAITTADAGFYLC 2025
G TV+L CR G P I+W K+G ++ P E D L++ ++T D+G Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWY 2085
A S AG +++V P V +SP V EG+ C + G+ + Q+ WY
Sbjct: 6088 FAASAAGNCSTLGKILV----QVPPRFVNKVRASPFV-EGEDAQFTCTIEGAPYPQIRWY 6142
Query: 2086 RRGGSLPPHTQVHGSR--------LRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
+ G L + L + S D G Y C + N G AS + +
Sbjct: 6143 KDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Score = 68.9 bits (167), Expect = 1e-10
Identities = 112/496 (22%), Positives = 180/496 (36%), Gaps = 97/496 (19%)
Query: 2741 GETLDLNCVVPGQAHAQVTWHKRGGSLP--SHH----QTRGS-RLRLHHVSPADSGEYVC 2793
GET+ L C V G ++W+K G ++ HH GS L L ++ DSG+Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087
Query: 2794 RVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQ 2853
++G G V VP P +R P EG+ C + G
Sbjct: 6088 FAASAAG--------NCSTLGKILVQVP-PRFVNKVRASP----FVEGEDAQFTCTIEGA 6134
Query: 2854 AHAQVTWHKRGGNLPARHQVHGP--------LLRLNQVSPADSGEYSCQVTGSSGTLEAS 2905
+ Q+ W+K G L ++ +L + S D G Y C++ G+ AS
Sbjct: 6135 PYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARAS 6194
Query: 2906 VLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL 2965
+ I+ P + + E + V E TL+ +A +VT
Sbjct: 6195 AELRIQS------PMLQAQEQCHREQLVAAV-EDTTLE-------RADQEVT-------- 6232
Query: 2966 PARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEAS----FTVTVPPSEGSSYRLRS 3021
+ L+ P G +GPGP + T + PP G+S +
Sbjct: 6233 ---------SVLKRLLGPKAPGPST-GDLTGPGPCPRGAPALQETGSQPPVTGTS---EA 6279
Query: 3022 PVISIDPPSSTVQQGQDASFKCLIH--DGAAPISLE---WKTRNQELEDNVHISPNGSII 3076
P + P + +G + + + + PI +E W G ++
Sbjct: 6280 PAVPPRVPQPLLHEGPEQEPEAIARAQEWTVPIRMEGAAWPGAG-----------TGELL 6328
Query: 3077 TIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVS 3136
V + T R A ++ PP++ V E V + G E +
Sbjct: 6329 WDVHSHVVRETTQRTYTYQA-------IDTHTARPPSMQVTIED-VQAQTGGTAQFEAII 6380
Query: 3137 AGEPRSSARWTRISST---PAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGT 3193
G+P+ S W + S +L Q+ G S + ++S DAG Y CLAQN G
Sbjct: 6381 EGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVAS---KDAGVYTCLAQNTGGQ 6437
Query: 3194 AQKQVEVIVDTGAMAP 3209
+ E++V G P
Sbjct: 6438 VLCKAELLVLGGDNEP 6453
Score = 67.0 bits (162), Expect = 4e-10
Identities = 65/257 (25%), Positives = 101/257 (39%), Gaps = 32/257 (12%)
Query: 3291 IILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL---PGRATARN 3347
+ L V PP + + GETV+L C GTP W + G ++ P +
Sbjct: 6006 LALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIED 6065
Query: 3348 E----LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQ 3403
L + DSG+Y C + G+ ++LVQ PP + V+
Sbjct: 6066 PDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFV----------NKVR 6115
Query: 3404 VTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQD--------GVLRIQN 3455
+P +E G +F C + Q+RW+K+G L G+ Q VL I+
Sbjct: 6116 ASPFVE----GEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRA 6171
Query: 3456 LDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGD 3515
+ G Y C+ G A+ASA+L IQ S ++ + + AVE L D
Sbjct: 6172 ASKEDLGLYECELVNRLGSARASAELRIQ---SPMLQAQEQCHREQLVAAVEDTTLERAD 6228
Query: 3516 PKPQVTWSKVGGHLRPG 3532
+ ++ G PG
Sbjct: 6229 QEVTSVLKRLLGPKAPG 6245
Score = 65.5 bits (158), Expect = 1e-09
Identities = 127/574 (22%), Positives = 208/574 (36%), Gaps = 108/574 (18%)
Query: 2261 TLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEAS 2320
++DL+ V G A W +R S+ R Y+ QA A +++S
Sbjct: 5955 SIDLNDQVEGDDRAFEVWQEREDSV---------RKYLLQARTAI-----------IKSS 5994
Query: 2321 ITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGS 2380
+ G Q LA P E + G+T+ L C V G ++W+K G +
Sbjct: 5995 WVKEICGIQ-QRLALPVWRPPDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKA 6053
Query: 2381 LPVR------HQTHGSL-LRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPAL 2433
+ V GS L L + DSG+Y+C AS G + +
Sbjct: 6054 VQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC--------FAASAAGNCSTLGKI-LV 6104
Query: 2434 GVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH-----GSRL 2488
V P + +S EG+ C + G + Q+ W+K G L ++ S L
Sbjct: 6105 QVPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL 6164
Query: 2489 RLLQVTPA---DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQ--GVAYPVRIESSSA 2543
+L + A D G Y C +V G+ AS + IQ + + Q +E ++
Sbjct: 6165 LVLVIRAASKEDLGLYECELVNRLGSARASAELRIQSPMLQAQEQCHREQLVAAVEDTTL 6224
Query: 2544 SLANGH-TLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHV 2602
A+ T L L+ +AP PS + G P+ PA
Sbjct: 6225 ERADQEVTSVLKRLLGPKAPG-----------PSTGDLTGPG-PCPRGAPA--------- 6263
Query: 2603 SNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIIT 2662
+ET + +G+S P+V P + P + EG + +AR + +
Sbjct: 6264 -----LQETGSQPPV--TGTSEAPAVPPRV----PQPLLHEGPEQEPE-AIARAQEWTVP 6311
Query: 2663 WYKRGGSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSA 2722
G + P A +GE + ++++ E + + + +A
Sbjct: 6312 IRMEGAAWPG----------------AGTGELLWDVHSHV-VRETTQRTYTYQAIDTHTA 6354
Query: 2723 PGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPS----HHQTRGS-- 2776
SM + IE + G T ++ G VTW+K L Q G+
Sbjct: 6355 RPPSMQVTIEDVQAQT--GGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTY 6412
Query: 2777 RLRLHHVSPADSGEYVCRVMGSSGPL--EASVLV 2808
L L HV+ D+G Y C + G + +A +LV
Sbjct: 6413 SLVLRHVASKDAGVYTCLAQNTGGQVLCKAELLV 6446
Score = 65.1 bits (157), Expect = 1e-09
Identities = 133/570 (23%), Positives = 198/570 (34%), Gaps = 112/570 (19%)
Query: 2453 TLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQ 2512
++DLN V G A W +R S+ R LLQ A ++ SS +
Sbjct: 5955 SIDLNDQVEGDDRAFEVWQEREDSV---------RKYLLQARTA--------IIKSSWVK 5997
Query: 2513 EASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGG 2572
E + IQQRL+ + + + +A L G T+ L C V I+WYK G
Sbjct: 5998 E---ICGIQQRLALPVWRPPDFEEELADCTAEL--GETVKLACRVTGTPKPVISWYKDGK 6052
Query: 2573 SLP-SRHQIV------GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHV 2625
++ H I+ L + +T DSG+Y+C ++ AG+ T + +Q
Sbjct: 6053 AVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ------- 6105
Query: 2626 PSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLP--SRHQTHGSH--- 2680
V P + + VEG+ C + P I WYK G L ++ QT
Sbjct: 6106 --VPPRFVNKVRASPFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSG 6163
Query: 2681 ---LRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH 2737
L + S D G Y C N + + AS + + SP R + ++
Sbjct: 6164 LLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQ----SPMLQAQEQCHREQLVAA- 6218
Query: 2738 VAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMG 2797
E TL+ Q V G P S L P G + G
Sbjct: 6219 -VEDTTLER----ADQEVTSVLKRLLGPKAPG-----PSTGDLTGPGPCPRGAPALQETG 6268
Query: 2798 SSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLK---CVVPGQA 2854
S P V T EA + VP P EP + A+ T+ ++ PG
Sbjct: 6269 SQPP----VTGTSEAP-AVPPRVPQPLLHEGPEQEPEAIARAQEWTVPIRMEGAAWPGAG 6323
Query: 2855 HAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSS 2914
++ W VH ++R Y+ Q + S+ VTIE
Sbjct: 6324 TGELLW-----------DVHSHVVR-----ETTQRTYTYQAIDTHTARPPSMQVTIED-- 6365
Query: 2915 PGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRG----GSLPARHQ 2970
++A + G T ++ G VTWYK S Q
Sbjct: 6366 --------------VQAQT-----GGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQ 6406
Query: 2971 THGS--QLRLHLVSPADSGEYVCRAASGPG 2998
G+ L L V+ D+G Y C A + G
Sbjct: 6407 QEGTTYSLVLRHVASKDAGVYTCLAQNTGG 6436
Score = 64.3 bits (155), Expect = 3e-09
Identities = 106/438 (24%), Positives = 155/438 (35%), Gaps = 75/438 (17%)
Query: 1876 TVQPGQLAEFRCSATGSPTPTLEW-TGGPGGQL-PAKAQIH----GGILRLPAVEPTDQA 1929
T + G+ + C TG+P P + W G Q+ P I L L ++ D
Sbjct: 6024 TAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSG 6083
Query: 1930 QYLCRAHSSAG--QQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI 1987
QY+C A S+AG + + ++ V +V+ SP G + C G P I
Sbjct: 6084 QYMCFAASAAGNCSTLGKILVQVPPRFVNKVRASP----FVEGEDAQFTCTIEGAPYPQI 6139
Query: 1988 TWRKEGGSLPP----QARSE-RTDIATLLIPAITTADAGFYLCVATSPAGTAQA----RI 2038
W K+G L Q SE R+ + L+I A + D G Y C + G+A+A RI
Sbjct: 6140 RWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRI 6199
Query: 2039 QVVVLSASD--------ASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTW------ 2084
Q +L A + A+ +E + VT L G + +T
Sbjct: 6200 QSPMLQAQEQCHREQLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPSTGDLTGPGPCPR 6259
Query: 2085 ----YRRGGSLPPHTQVHGSRLRLPQV-------SPADSGEYVCRVEN------------ 2121
+ GS PP T + P+V P E + R +
Sbjct: 6260 GAPALQETGSQPPVTGTSEAPAVPPRVPQPLLHEGPEQEPEAIARAQEWTVPIRMEGAAW 6319
Query: 2122 -GSGPKEASITVS---VLHGTHSGPSYTPVPGST-RP--IRIEPSSSHVAEGQTLDLNCV 2174
G+G E V V T +Y + T RP +++ G T +
Sbjct: 6320 PGAGTGELLWDVHSHVVRETTQRTYTYQAIDTHTARPPSMQVTIEDVQAQTGGTAQFEAI 6379
Query: 2175 VPGQAHAQVTWHKRG----GSLPARHQTHGSL--LRLHQVTPADSGEYVCHVVGTSGPLE 2228
+ G VTW+K S Q G+ L L V D+G Y C T G
Sbjct: 6380 IEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGG--- 6436
Query: 2229 ASVLVTIEASVIPGPIPP 2246
VL E V+ G P
Sbjct: 6437 -QVLCKAELLVLGGDNEP 6453
Score = 61.2 bits (147), Expect = 2e-08
Identities = 82/357 (22%), Positives = 122/357 (34%), Gaps = 85/357 (23%)
Query: 3385 PPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG- 3443
PP LP+ + + + P Q + G V F C V +RWFK+G L
Sbjct: 5112 PPEPLPSL-LTSDAAPVFLTELQNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDD 5170
Query: 3444 ----HSVQDG--VLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQA------------ 3485
+ Q G L I + + G Y C A G + A+L +
Sbjct: 5171 HYMINEDQQGGHQLIITAVVPADMGVYRCLAENSMGVSSTKAELRVDLTSTDYDTAADAT 5230
Query: 3486 ----------------------------LPSVLINIRTSVQTVVVGHAVEFECLALGDPK 3517
LP V+ +R +Q +F+ G P
Sbjct: 5231 ESSSYFSAQGYLSSREQEGTESTTDEGQLPQVVEELR-DLQVAPGTRLAKFQLKVKGYPA 5289
Query: 3518 PQVTWSKVG------GHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLL 3571
P++ W K G H+R + + I V D+GQY +NA G S LL
Sbjct: 5290 PRLYWFKDGQPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLL 5349
Query: 3572 VQALP------------QISMPQEV------RVPAGSAAVFPCIASGYPTPDISWSKLDG 3613
V+ Q+ P+ + +V GS+ F G P P + W + +
Sbjct: 5350 VRGPDEPEEKPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEA 5409
Query: 3614 S-----LPPD-------SRLENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
+ PD S + + L+L V Q GTY C A+N G+ A L V
Sbjct: 5410 ERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHV 5466
Score = 60.1 bits (144), Expect = 5e-08
Identities = 88/415 (21%), Positives = 137/415 (33%), Gaps = 76/415 (18%)
Query: 2166 GQTLDLNCVVPGQAHAQVTWHKRGGSLPAR------HQTHGSL-LRLHQVTPADSGEYVC 2218
G+T+ L C V G ++W+K G ++ GS L L +T DSG+Y+C
Sbjct: 6028 GETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMC 6087
Query: 2219 HVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTW 2278
+G S L I V P + VR +S EG+ +C + G + Q+ W
Sbjct: 6088 FAASAAG--NCSTLGKILVQVPPRFVNKVR----ASPFVEGEDAQFTCTIEGAPYPQIRW 6141
Query: 2279 YKRGGSLPARHQVRGSR--------LYIFQASPADAGQYVCRASNGMEASITVTVTGTQG 2330
YK G L ++ + L I AS D G Y C N + ++ Q
Sbjct: 6142 YKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELRIQS 6201
Query: 2331 ANLAYP--------AGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVT--------- 2373
L + + +E + +V L PG S +T
Sbjct: 6202 PMLQAQEQCHREQLVAAVEDTTLERADQEVTSVLKRLLGPKAPGPSTGDLTGPGPCPRGA 6261
Query: 2374 --WHKRGGSLPVRHQTHGSLL------RLYQASPADSGEYVCRVLGSSVPLEAS------ 2419
+ G PV + + L P E + R +VP+
Sbjct: 6262 PALQETGSQPPVTGTSEAPAVPPRVPQPLLHEGPEQEPEAIARAQEWTVPIRMEGAAWPG 6321
Query: 2420 --------------VLVTIEPAGSVPALGV----TPTVRIESSSSQVAEGQTLDLNCLVA 2461
V T + + A+ P++++ Q G T ++
Sbjct: 6322 AGTGELLWDVHSHVVRETTQRTYTYQAIDTHTARPPSMQVTIEDVQAQTGGTAQFEAIIE 6381
Query: 2462 GQAHAQVTWHKRG----GSLPARHQVHGS--RLRLLQVTPADSGEYVCRVVGSSG 2510
G VTW+K S Q G+ L L V D+G Y C + G
Sbjct: 6382 GDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNTGG 6436
Score = 57.4 bits (137), Expect = 3e-07
Identities = 94/437 (21%), Positives = 145/437 (33%), Gaps = 93/437 (21%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQ----QRHQGS-ELHFPSVQPSDAGVYI 1745
G + L C+V+G+P W + DG+ V + GS L S+ D+G Y+
Sbjct: 6028 GETVKLACRVTGTPKPVISWYK-DGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQYM 6086
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV 1805
C + + ++ ++LV P V + R+ G D F CT + +P +
Sbjct: 6087 CFAASAAGNCSTLGKILVQVPPR-----FVNKVRASPFVEGEDAQFTCTIEG-APYPQIR 6140
Query: 1806 WTRLHNGKLPTRAMDFNG---------ILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLH 1856
W + +G L T F +L IR D G Y C N + +A L
Sbjct: 6141 WYK--DGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECELVNRLGSARASAELR 6198
Query: 1857 VQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHG- 1915
+Q S L A H QL R A T L+ GP P+ + G
Sbjct: 6199 IQ-SPMLQAQ-EQCHREQLVAAVEDTTLER--ADQEVTSVLKRLLGPKAPGPSTGDLTGP 6254
Query: 1916 --------------------GILRLPAVEPTDQAQYLCRAHSSAGQQVARA--------- 1946
G PAV P L + +ARA
Sbjct: 6255 GPCPRGAPALQETGSQPPVTGTSEAPAVPPRVPQPLLHEGPEQEPEAIARAQEWTVPIRM 6314
Query: 1947 ---------------------------------VLHVHGGGGPRVQVSPERTQVHAGRTV 1973
+ H P +QV+ E Q G T
Sbjct: 6315 EGAAWPGAGTGELLWDVHSHVVRETTQRTYTYQAIDTHTARPPSMQVTIEDVQAQTGGTA 6374
Query: 1974 RLYCRAAGVPSATITWRKEGGSLPPQARSERTDIAT---LLIPAITTADAGFYLCVATSP 2030
+ G P ++TW K+ L R + T L++ + + DAG Y C+A +
Sbjct: 6375 QFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCLAQNT 6434
Query: 2031 AGTAQARIQVVVLSASD 2047
G + +++VL +
Sbjct: 6435 GGQVLCKAELLVLGGDN 6451
Score = 57.0 bits (136), Expect = 4e-07
Identities = 83/337 (24%), Positives = 117/337 (34%), Gaps = 77/337 (22%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSG-----TQQRHQGSELHFPSVQPSDAG 1742
V G S C V+G P W + DG+ + + + G +L +V P+D G
Sbjct: 5137 VQDGYPVSFDCVVTGQPMPSVRWFK-DGKLLEEDDHYMINEDQQGGHQLIITAVVPADMG 5195
Query: 1743 VYICTCRNLHQSNTSRAELLV-------------TEAPS--------------------- 1768
VY C N ++++AEL V TE+ S
Sbjct: 5196 VYRCLAENSMGVSSTKAELRVDLTSTDYDTAADATESSSYFSAQGYLSSREQEGTESTTD 5255
Query: 1769 -KPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN----- 1822
+ VEE R V PG + PA L W + +G+ T +
Sbjct: 5256 EGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFK--DGQPLTASAHIRMTDKK 5313
Query: 1823 --GILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA-SGTLSAPVVSIH----PPQL 1875
L I +V D+G Y SN +A L V+ P +H PP++
Sbjct: 5314 ILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEEKPASDVHEQLVPPRM 5373
Query: 1876 -------TVQPGQLAEFRCSATGSPTPTLEW-------------TGGPGGQLPAKAQIHG 1915
V+ G F G P PT+ W PG + + AQ H
Sbjct: 5374 LERFTPKKVKKGSSITFSVKVEGRPVPTVHWLREEAERGVLWIGPDTPGYTVASSAQQHS 5433
Query: 1916 GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG 1952
L L V Q Y C A ++AGQ + A LHV G
Sbjct: 5434 --LVLLDVGRQHQGTYTCIASNAAGQALCSASLHVSG 5468
Score = 56.6 bits (135), Expect = 5e-07
Identities = 126/573 (21%), Positives = 208/573 (36%), Gaps = 111/573 (19%)
Query: 2941 TLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPE 3000
++DLN V G A W +R S+ + + Q R ++ + E +C G +
Sbjct: 5955 SIDLNDQVEGDDRAFEVWQEREDSV----RKYLLQARTAIIKSSWVKE-IC------GIQ 6003
Query: 3001 QEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRN 3060
Q + V PP + T + G+ C + P+ +K
Sbjct: 6004 QRLALPVWRPPD-----------FEEELADCTAELGETVKLACRVTGTPKPVISWYKDGK 6052
Query: 3061 QELEDNVHI---SPNGSIITIVGTRPS-NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSV 3116
D HI P+GS I+ + + G Y C A++A G ++ + V PP
Sbjct: 6053 AVQVDPHHILIEDPDGSCALILDSLTGVDSGQYMCFAASAAGNCSTLGKILVQVPPRFVN 6112
Query: 3117 LPEGPVWVKVGKAVTLECVSAGEPRSSARWTR---ISSTPAK---LEQRTYGLMDSHAVL 3170
+V+ G+ C G P RW + + +T K L + GL+ VL
Sbjct: 6113 KVRASPFVE-GEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLL----VL 6167
Query: 3171 QISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE---AELTVEAGH 3227
I +A D G Y C N LG+A+ E+ + +P +QA+E E V A
Sbjct: 6168 VIRAASKEDLGLYECELVNRLGSARASAELRIQ-------SPMLQAQEQCHREQLVAAVE 6220
Query: 3228 TATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGDTLIIPRVA---QQDSGQYICNATSPA 3284
TL + + ++P P L G PR A Q+ Q TS
Sbjct: 6221 DTTLERADQEVTSVLKRLLGPKAPGPSTGDLTGPG-PCPRGAPALQETGSQPPVTGTS-- 6277
Query: 3285 GHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHG---TPPLTFQWSRVGSSLPG 3341
E+P VP+ + G + + +A T P+ + G++ PG
Sbjct: 6278 -----------EAPAVPPRVPQ-PLLHEGPEQEPEAIARAQEWTVPIRME----GAAWPG 6321
Query: 3342 RATARNELL-----HFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPA 3396
T ELL H R + + Y+ T+ T+ P
Sbjct: 6322 AGT--GELLWDVHSHVVRETTQRTYTYQAIDTH----------------------TARP- 6356
Query: 3397 GSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV---QDGV--- 3450
P++QVT + G + +F + D + W+K+ QL + Q+G
Sbjct: 6357 ---PSMQVTIEDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYS 6413
Query: 3451 LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI 3483
L ++++ G Y C A G+ A+L++
Sbjct: 6414 LVLRHVASKDAGVYTCLAQNTGGQVLCKAELLV 6446
Score = 53.1 bits (126), Expect = 6e-06
Identities = 82/347 (23%), Positives = 124/347 (35%), Gaps = 44/347 (12%)
Query: 1656 GYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDG 1715
GY+ + +G + + Q P VVE + P + +V G P YW + DG
Sbjct: 5240 GYLSSREQEGTESTTDEGQLPQVVEELRDLQVAPGTRLAKFQLKVKGYPAPRLYWFK-DG 5298
Query: 1716 RPVPSGTQQRHQGSE----LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLV--TEAPSK 1769
+P+ + R + L SV D+G Y N + S A LLV + P +
Sbjct: 5299 QPLTASAHIRMTDKKILHTLEIISVTREDSGQYAAYISNAMGAAYSSARLLVRGPDEPEE 5358
Query: 1770 PITVTVEEQ----------RSQSVRPGADVTFICTAKSKSPAYTLVWTR--LHNGKL--- 1814
V EQ + V+ G+ +TF + + P T+ W R G L
Sbjct: 5359 KPASDVHEQLVPPRMLERFTPKKVKKGSSITFSVKVEGR-PVPTVHWLREEAERGVLWIG 5417
Query: 1815 ------PTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVV 1868
+ L + +V GTY C SN +A+LHV P V
Sbjct: 5418 PDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAGQALCSASLHVS-----GLPKV 5472
Query: 1869 SIHPPQLTVQPGQLAEF------RCSATGSPTPTLEWTGGPGGQLPAKAQIHGGILRLPA 1922
Q V+ ++ F SA G T + GG + P A+ G L L
Sbjct: 5473 E---EQEKVKEALISTFLQGTTQAISAQGLETASFADLGGQRKEEPLAAKEALGHLSLAE 5529
Query: 1923 VEPTDQAQYL-CRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVH 1968
V + Q L + ++ +A L V GG +P + H
Sbjct: 5530 VGTEEFLQKLTSQITEMVSAKITQAKLQVPGGDSDEDSKTPSASPRH 5576
Score = 51.6 bits (122), Expect = 2e-05
Identities = 47/196 (23%), Positives = 76/196 (38%), Gaps = 24/196 (12%)
Query: 2245 PPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPA-RHQV------RGSRLY 2297
P E + T G+T+ L+C V G ++WYK G ++ H + L
Sbjct: 6014 PDFEEELADCTAELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALI 6073
Query: 2298 IFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQT 2357
+ + D+GQY+C A++ T+ Q P +R P EG+
Sbjct: 6074 LDSLTGVDSGQYMCFAASAAGNCSTLGKILVQ-----VPPRFVNKVRASP----FVEGED 6124
Query: 2358 LDLNCVVPGQSHAQVTWHKRGGSLPV--RHQTHGS------LLRLYQASPADSGEYVCRV 2409
C + G + Q+ W+K G L + QT +L + AS D G Y C +
Sbjct: 6125 AQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGLLVLVIRAASKEDLGLYECEL 6184
Query: 2410 LGSSVPLEASVLVTIE 2425
+ AS + I+
Sbjct: 6185 VNRLGSARASAELRIQ 6200
Score = 50.1 bits (118), Expect = 5e-05
Identities = 25/75 (33%), Positives = 35/75 (46%)
Query: 414 ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESD 473
E +QA G T F + G P P + W + + R++ EG +L++R V D
Sbjct: 6364 EDVQAQTGGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKD 6423
Query: 474 QGAYTCEAMNARGMV 488
G YTC A N G V
Sbjct: 6424 AGVYTCLAQNTGGQV 6438
Score = 49.7 bits (117), Expect = 6e-05
Identities = 26/84 (30%), Positives = 41/84 (48%), Gaps = 1/84 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P+ +T P+ + S G+ T +C +G PTP ++W + + + R + +G L
Sbjct: 10 PRFLTRPKAFV-VSVGKDATLSCQIVGNPTPQVSWEKDQQPVAAGARFRLAQDGDLYRLT 68
Query: 466 IRDVKESDQGAYTCEAMNARGMVF 489
I D+ D G Y C A NA G F
Sbjct: 69 ILDLALGDSGQYVCRARNAIGEAF 92
Score = 47.0 bits (110), Expect = 4e-04
Identities = 36/105 (34%), Positives = 47/105 (44%), Gaps = 8/105 (7%)
Query: 2826 APPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQV-------HGPLL 2878
AP E S V GQ++ L C V Q AQ TW K G L + +V + LL
Sbjct: 7462 APTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLL 7521
Query: 2879 RLNQVSPADSGEYSCQVTGSSGTLEAS-VLVTIEPSSPGPIPAPG 2922
+ V D G Y+C V+ + GT+ + VL E S P P G
Sbjct: 7522 TILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSSPCPDIG 7566
Score = 46.6 bits (109), Expect = 5e-04
Identities = 31/107 (28%), Positives = 47/107 (43%), Gaps = 13/107 (12%)
Query: 389 DEESDCPDRSDEFGCMPPQVV---TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWG 445
DE + P +PP+++ TP + +G ++TF+ G P P ++W
Sbjct: 5354 DEPEEKPASDVHEQLVPPRMLERFTPKK----VKKGSSITFSVKVEGRPVPTVHWLREEA 5409
Query: 446 HI------PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
P P TV S + +L++ DV QG YTC A NA G
Sbjct: 5410 ERGVLWIGPDTPGYTVASSAQQHSLVLLDVGRQHQGTYTCIASNAAG 5456
Score = 45.4 bits (106), Expect = 0.001
Identities = 32/98 (32%), Positives = 44/98 (44%), Gaps = 7/98 (7%)
Query: 2437 PTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQV-------HGSRLR 2489
PT E S V GQ++ L C V+ Q AQ TW K G L + +V + L
Sbjct: 7463 PTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLT 7522
Query: 2490 LLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGS 2527
+L V D G Y C V + GT + ++ +R S S
Sbjct: 7523 ILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSS 7560
Score = 45.4 bits (106), Expect = 0.001
Identities = 32/85 (37%), Positives = 39/85 (45%), Gaps = 10/85 (11%)
Query: 2250 ESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSR-------LYIFQAS 2302
E S TV GQ++ L+C V+ Q AQ TW K G L + +V S L I
Sbjct: 7468 ELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVV 7527
Query: 2303 PADAGQYVCRASNGMEASITVTVTG 2327
D G Y C SN + TVT TG
Sbjct: 7528 AEDLGVYTCSVSNALG---TVTTTG 7549
Score = 45.1 bits (105), Expect = 0.002
Identities = 33/127 (25%), Positives = 51/127 (40%), Gaps = 7/127 (5%)
Query: 3211 APQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRL-------EGDTL 3263
AP E ++ TV G + TL C + PA WSK +PL R+ L
Sbjct: 7462 APTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLL 7521
Query: 3264 IIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAH 3323
I V +D G Y C+ ++ G T +L P ++ P+ V A + +
Sbjct: 7522 TILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSSPCPDIGEVYADGVLLVWKPVE 7581
Query: 3324 GTPPLTF 3330
P+T+
Sbjct: 7582 SYGPVTY 7588
Score = 44.3 bits (103), Expect = 0.003
Identities = 30/100 (30%), Positives = 40/100 (40%), Gaps = 10/100 (10%)
Query: 389 DEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI- 447
D E+ C +++ F P SI+ G TF C G P P ++W + +
Sbjct: 100 DAEAACAEQAPHFLLRPT--------SIRVREGSEATFRCRVGGSPRPAVSWSKDGRRLG 151
Query: 448 -PSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
P PRV V G L IR + D G Y A N G
Sbjct: 152 EPDGPRVRVEELGEASALRIRAARPRDGGTYEVRAENPLG 191
Score = 43.1 bits (100), Expect = 0.006
Identities = 22/75 (29%), Positives = 35/75 (46%), Gaps = 1/75 (1%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
P V P +S+QA G T T C + PT + W + ++ R +G L
Sbjct: 3888 PQPVFREPLQSLQAEEGSTATLQC-ELSEPTATVVWSKGGLQLQANGRREPRLQGCTAEL 3946
Query: 465 IIRDVKESDQGAYTC 479
+++D++ D G YTC
Sbjct: 3947 VLQDLQREDTGEYTC 3961
Score = 42.4 bits (98), Expect = 0.010
Identities = 27/85 (31%), Positives = 37/85 (43%), Gaps = 3/85 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRG- 462
+PP+ V R S G+ FTC G P P I W + + + + SE G
Sbjct: 6106 VPPRFVNKVRAS-PFVEGEDAQFTCTIEGAPYPQIRWYKDGALLTTGNKFQTLSEPRSGL 6164
Query: 463 -TLIIRDVKESDQGAYTCEAMNARG 486
L+IR + D G Y CE +N G
Sbjct: 6165 LVLVIRAASKEDLGLYECELVNRLG 6189
Score = 42.0 bits (97), Expect = 0.013
Identities = 35/114 (30%), Positives = 49/114 (42%), Gaps = 8/114 (7%)
Query: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVG 2582
RLSG S A E S ++ G ++ L C V++Q TW K G L S +++
Sbjct: 7452 RLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLI 7511
Query: 2583 SR-------LRIPQVTPADSGEYVCHVSNGAGS-RETSLIVTIQGSGSSHVPSV 2628
S L I V D G Y C VSN G+ T ++ + SS P +
Sbjct: 7512 SATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSSPCPDI 7565
Score = 42.0 bits (97), Expect = 0.013
Identities = 28/91 (30%), Positives = 40/91 (43%), Gaps = 7/91 (7%)
Query: 3496 SVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLR-------PGIVQSGGVVRIAHVELA 3548
S +TVV+G +V C P Q TWSK G L +++ ++ I V
Sbjct: 7470 SDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAE 7529
Query: 3549 DAGQYRCTATNAAGTTQSHVLLLVQALPQIS 3579
D G Y C+ +NA GT + +L P S
Sbjct: 7530 DLGVYTCSVSNALGTVTTTGVLRKAERPSSS 7560
Score = 41.6 bits (96), Expect = 0.018
Identities = 28/93 (30%), Positives = 35/93 (37%), Gaps = 7/93 (7%)
Query: 3582 QEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLENN-------MLMLPSVRPQ 3634
Q V G F C+ +G P P + W K L D N L++ +V P
Sbjct: 5133 QNQEVQDGYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGHQLIITAVVPA 5192
Query: 3635 DAGTYVCTATNRQGKVKAFAHLQVPERVVPYFT 3667
D G Y C A N G A L+V Y T
Sbjct: 5193 DMGVYRCLAENSMGVSSTKAELRVDLTSTDYDT 5225
Score = 41.6 bits (96), Expect = 0.018
Identities = 32/97 (32%), Positives = 40/97 (41%), Gaps = 6/97 (6%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI-IRDVKESDQGAYTC 479
GQ+VT C P W + + S RV +++ L+ I V D G YTC
Sbjct: 7477 GQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTC 7536
Query: 480 EAMNARGMVFGIPDGVLELV--PQRGPCPD-GHFYLE 513
NA G V GVL P PCPD G Y +
Sbjct: 7537 SVSNALGTV--TTTGVLRKAERPSSSPCPDIGEVYAD 7571
Score = 40.4 bits (93), Expect = 0.039
Identities = 29/102 (28%), Positives = 43/102 (42%), Gaps = 7/102 (6%)
Query: 2629 SPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQT-------HGSHL 2681
+P E S TVV GQ++ L C V+ QP A TW K G L S + + L
Sbjct: 7462 APTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLL 7521
Query: 2682 RLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAP 2723
+ + D G Y C +N + + + V+ + S P
Sbjct: 7522 TILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPSSSPCP 7563
Score = 40.0 bits (92), Expect = 0.051
Identities = 40/158 (25%), Positives = 63/158 (39%), Gaps = 13/158 (8%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFP-----SVQPSDAGVYI 1745
G S +L CQVS P WS+ DG P+ S ++ + +F V D GVY
Sbjct: 7477 GQSVTLACQVSAQPAAQATWSK-DGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYT 7535
Query: 1746 CTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRS-------QSVRPGADVTFICTAKSK 1798
C+ N + T+ L E PS + E + + V VT+I +
Sbjct: 7536 CSVSNALGTVTTTGVLRKAERPSSSPCPDIGEVYADGVLLVWKPVESYGPVTYIVQCSLE 7595
Query: 1799 SPAYTLVWTRLHNGKLPTRAMDFNGILTIRNVQLSDAG 1836
++T + + + + T + G T R +S AG
Sbjct: 7596 GGSWTTLASDIFDCCYLTSKLSRGGTYTFRTACVSKAG 7633
Score = 39.3 bits (90), Expect = 0.087
Identities = 25/95 (26%), Positives = 41/95 (43%), Gaps = 2/95 (2%)
Query: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVK 470
P +QA G + T +C T + W + + S +V V + G L+++
Sbjct: 1631 PAHREVQAEAGASATLSCEVAQAQTEV-TWYKDGKKLSSSSKVRVEAVGCTRRLVVQQAG 1689
Query: 471 ESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPC 505
++D G Y+CEA R + F + LE PC
Sbjct: 1690 QADAGEYSCEAGGQR-LSFRLHVAELEPQISERPC 1723
Score = 39.3 bits (90), Expect = 0.087
Identities = 21/70 (30%), Positives = 31/70 (44%), Gaps = 1/70 (1%)
Query: 418 ASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHP-RVTVTSEGGRGTLIIRDVKESDQGA 476
A G+TV C G P P+I+W + + P + + G LI+ + D G
Sbjct: 6025 AELGETVKLACRVTGTPKPVISWYKDGKAVQVDPHHILIEDPDGSCALILDSLTGVDSGQ 6084
Query: 477 YTCEAMNARG 486
Y C A +A G
Sbjct: 6085 YMCFAASAAG 6094
Score = 38.9 bits (89), Expect = 0.11
Identities = 20/70 (28%), Positives = 36/70 (51%), Gaps = 1/70 (1%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
+QA G + T +C T ++ W + + S +V V ++G R L+++ ++D G
Sbjct: 992 VQAEAGASATLSCEVAQAQTEVM-WYKDGKKLSSSLKVHVEAKGCRRRLVVQQAGKTDAG 1050
Query: 476 AYTCEAMNAR 485
Y+CEA R
Sbjct: 1051 DYSCEARGQR 1060
Score = 38.9 bits (89), Expect = 0.11
Identities = 51/214 (23%), Positives = 80/214 (37%), Gaps = 43/214 (20%)
Query: 2062 VTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLRLPQVSPADSG-------- 2113
+TE ++ D++ ++A +A + +R S P + H LP PA+ G
Sbjct: 7367 ITE-ESEDVDALLAEAAVGR----KRKWSSPSRSLFHFPGRHLPLDEPAELGLRERVKAS 7421
Query: 2114 -EYVCRVENG-------SGPKE-----ASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSS 2160
E++ R+ G GP AS +S L P++ E S
Sbjct: 7422 VEHISRILKGRPEGLEKEGPPRKKPGLASFRLSGLKSWDRAPTFLR----------ELSD 7471
Query: 2161 SHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQT-------HGSLLRLHQVTPADS 2213
V GQ++ L C V Q AQ TW K G L + + + LL + V D
Sbjct: 7472 ETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDL 7531
Query: 2214 GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
G Y C V G + + ++ P P +
Sbjct: 7532 GVYTCSVSNALGTVTTTGVLRKAERPSSSPCPDI 7565
Score = 38.9 bits (89), Expect = 0.11
Identities = 22/72 (30%), Positives = 34/72 (47%), Gaps = 3/72 (4%)
Query: 3124 VKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTY--GLMDSHAVLQISSAKPSDAG 3181
V +G++VTL C + +P + A W++ P + R + + +L I D G
Sbjct: 7474 VVLGQSVTLACQVSAQPAAQATWSK-DGAPLESSSRVLISATLKNFQLLTILVVVAEDLG 7532
Query: 3182 TYVCLAQNALGT 3193
Y C NALGT
Sbjct: 7533 VYTCSVSNALGT 7544
Score = 38.9 bits (89), Expect = 0.11
Identities = 23/87 (26%), Positives = 37/87 (42%), Gaps = 4/87 (4%)
Query: 1970 GRTVRLYCRAAGVPSATITWRKEGGSLPPQAR----SERTDIATLLIPAITTADAGFYLC 2025
G++V L C+ + P+A TW K+G L +R + + L I + D G Y C
Sbjct: 7477 GQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTC 7536
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPP 2052
++ GT + +SP P
Sbjct: 7537 SVSNALGTVTTTGVLRKAERPSSSPCP 7563
Score = 38.5 bits (88), Expect = 0.15
Identities = 32/113 (28%), Positives = 50/113 (44%), Gaps = 12/113 (10%)
Query: 2043 LSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV----- 2097
L + D +P ++ E S +V GQ++ L C V+ AQ TW + G L ++V
Sbjct: 7456 LKSWDRAPTFLR-ELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISAT 7514
Query: 2098 --HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVP 2148
+ L + V D G Y C V N G ++T + + PS +P P
Sbjct: 7515 LKNFQLLTILVVVAEDLGVYTCSVSNALG----TVTTTGVLRKAERPSSSPCP 7563
Score = 38.1 bits (87), Expect = 0.19
Identities = 23/69 (33%), Positives = 32/69 (46%), Gaps = 3/69 (4%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHI--PSHPRVTVTSEGGRGTLIIRDVKESDQGAYT 478
G V+F CV G P P + W + + H + +GG LII V +D G Y
Sbjct: 5140 GYPVSFDCVVTGQPMPSVRWFKDGKLLEEDDHYMINEDQQGGH-QLIITAVVPADMGVYR 5198
Query: 479 CEAMNARGM 487
C A N+ G+
Sbjct: 5199 CLAENSMGV 5207
Score = 38.1 bits (87), Expect = 0.19
Identities = 39/141 (27%), Positives = 57/141 (40%), Gaps = 18/141 (12%)
Query: 3586 VPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR------LEN-NMLMLPSVRPQDAGT 3638
V G + C S P +WSK L SR L+N +L + V +D G
Sbjct: 7474 VVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLGV 7533
Query: 3639 YVCTATNRQGKVKAFAHLQVPERVVPYFTQTPYSFLPLPTIKDAYRKFEIKITFRPDSAD 3698
Y C+ +N G V L+ ER S P P I + Y + + ++P +
Sbjct: 7534 YTCSVSNALGTVTTTGVLRKAERP---------SSSPCPDIGEVYAD-GVLLVWKPVESY 7583
Query: 3699 GMLLYNGQKRVP-GSPTNLAN 3718
G + Y Q + GS T LA+
Sbjct: 7584 GPVTYIVQCSLEGGSWTTLAS 7604
Score = 37.7 bits (86), Expect = 0.25
Identities = 28/93 (30%), Positives = 38/93 (40%), Gaps = 7/93 (7%)
Query: 3309 SVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGR------ATARN-ELLHFERAAPEDSG 3361
+V G++V L C P WS+ G+ L AT +N +LL ED G
Sbjct: 7473 TVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVVAEDLG 7532
Query: 3362 RYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSI 3394
Y C V+N +G+ L P S P I
Sbjct: 7533 VYTCSVSNALGTVTTTGVLRKAERPSSSPCPDI 7565
Score = 37.0 bits (84), Expect = 0.43
Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 6/95 (6%)
Query: 397 RSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVT 456
R++ PP T + + G+ +C G P P W+ + G + + R V
Sbjct: 231 RAEGAPASPPSTGT---RTCTVTEGKHARLSCYVTGEPKPETVWKKD-GQLVTEGRRHVV 286
Query: 457 SEGGRGTLIIRDV--KESDQGAYTCEAMNARGMVF 489
E + +++ + K+SD+G YTC A N G +
Sbjct: 287 YEDAQENFVLKILFCKQSDRGLYTCTASNLVGQTY 321
Score = 37.0 bits (84), Expect = 0.43
Identities = 19/73 (26%), Positives = 34/73 (46%), Gaps = 1/73 (1%)
Query: 413 RESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKES 472
R +QA G + T +C T + W + + S +V + + G L+++ ++
Sbjct: 897 RRKLQAEAGASATLSCEVAQAQTEV-TWYKDGKKLSSSSKVCMEATGCTRRLVVQQAGQA 955
Query: 473 DQGAYTCEAMNAR 485
D G Y+CEA R
Sbjct: 956 DAGEYSCEAGGQR 968
Score = 37.0 bits (84), Expect = 0.43
Identities = 19/70 (27%), Positives = 34/70 (48%), Gaps = 1/70 (1%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
+QA G T +C + P + W + + S +V + +G L+++ V ++D G
Sbjct: 1176 VQAEAGTTAMLSC-EVAQPQTEVTWYKDGKKLSSSSKVRMEVKGCTRRLVVQQVGKADAG 1234
Query: 476 AYTCEAMNAR 485
Y+CEA R
Sbjct: 1235 EYSCEAGGQR 1244
Score = 36.6 bits (83), Expect = 0.56
Identities = 18/75 (24%), Positives = 36/75 (48%), Gaps = 1/75 (1%)
Query: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVK 470
P +QA G + T +C T + W + + S +V + + G L++++
Sbjct: 1539 PASREVQAEAGTSATLSCEVAQAQTEV-TWYKDGKKLSSSSKVRMEAVGCTRRLVVQEAG 1597
Query: 471 ESDQGAYTCEAMNAR 485
++D G Y+C+A + R
Sbjct: 1598 QADAGEYSCKAGDQR 1612
Score = 36.6 bits (83), Expect = 0.56
Identities = 22/75 (29%), Positives = 30/75 (40%), Gaps = 1/75 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P + P E + G+ V C TP+ +W + I + V EG L+
Sbjct: 2826 PAAIIKPLEDQWVAPGEDVELRCELSRAGTPV-HWLKDRKAIRKSQKYDVVCEGTMAMLV 2884
Query: 466 IRDVKESDQGAYTCE 480
IR D G YTCE
Sbjct: 2885 IRGASLKDAGEYTCE 2899
Score = 35.8 bits (81), Expect = 0.96
Identities = 44/160 (27%), Positives = 60/160 (37%), Gaps = 25/160 (15%)
Query: 2862 KRGGNLPARHQVHGPLLRLNQVSPADSG---EYSCQVTGSSGTLEASVLVTIEPSSPGPI 2918
KR + P+R H P L PA+ G V S L+ +E P P
Sbjct: 7386 KRKWSSPSRSLFHFPGRHLPLDEPAELGLRERVKASVEHISRILKGRP-EGLEKEGP-PR 7443
Query: 2919 PAPGLAQ------------PIYI-EASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSL 2965
PGLA P ++ E S V GQ++ L C V Q AQ TW K G L
Sbjct: 7444 KKPGLASFRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPL 7503
Query: 2966 PARHQT-------HGSQLRLHLVSPADSGEYVCRAASGPG 2998
+ + + L + +V D G Y C ++ G
Sbjct: 7504 ESSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALG 7543
Score = 35.0 bits (79), Expect = 1.6
Identities = 23/76 (30%), Positives = 33/76 (43%), Gaps = 3/76 (3%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+PPQ P ES Q + G+ V+ + +I W I R V S+G +
Sbjct: 4623 VPPQPSAP--ESRQVAAGEDVSLELEVVAEAGEVI-WHKGMERIQPGGRFEVVSQGRQQM 4679
Query: 464 LIIRDVKESDQGAYTC 479
L+I+ DQG Y C
Sbjct: 4680 LVIKGFTAEDQGEYHC 4695
Score = 34.7 bits (78), Expect = 2.1
Identities = 17/70 (24%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
++ G + T +C T + W + + S +V + + G L+++ ++D G
Sbjct: 1268 VRTEAGASATLSCEVAQAQTEV-TWYKDGKKLSSSSKVRIEAAGCMRQLVVQQAGQADAG 1326
Query: 476 AYTCEAMNAR 485
YTCEA R
Sbjct: 1327 EYTCEAGGQR 1336
Score = 34.7 bits (78), Expect = 2.1
Identities = 26/108 (24%), Positives = 46/108 (42%), Gaps = 14/108 (12%)
Query: 3296 ESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLP----------GRATA 3345
E P ++ T + Q G+ ++L+C+ + +W + G L G T
Sbjct: 4896 EGPMFSHTFGD-TEAQVGDALRLECVVASKADVRARWLKDGVELTDGRHHHIDQLGDGTC 4954
Query: 3346 RNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATS 3393
+ +RA D+G Y C+V+NK G A ++V G ++S
Sbjct: 4955 SLLITGLDRA---DAGCYTCQVSNKFGQVTHSACVVVSGSESEAESSS 4999
Score = 34.7 bits (78), Expect = 2.1
Identities = 24/83 (28%), Positives = 33/83 (39%), Gaps = 3/83 (3%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPS---GTQQRHQGSELHFPSVQPSDAGVYICT 1747
GG+ + G P W ++ + V S QQ L V DAGVY C
Sbjct: 6371 GGTAQFEAIIEGDPQPSVTWYKDSVQLVDSTRLSQQQEGTTYSLVLRHVASKDAGVYTCL 6430
Query: 1748 CRNLHQSNTSRAELLVTEAPSKP 1770
+N +AELLV ++P
Sbjct: 6431 AQNTGGQVLCKAELLVLGGDNEP 6453
Score = 34.7 bits (78), Expect = 2.1
Identities = 47/186 (25%), Positives = 68/186 (36%), Gaps = 33/186 (17%)
Query: 2960 KRGGSLPARHQTHGSQLRLHLVSPADSG---------EYVCRAASG--PGPEQEASFTVT 3008
KR S P+R H L L PA+ G E++ R G G E+E
Sbjct: 7386 KRKWSSPSRSLFHFPGRHLPLDEPAELGLRERVKASVEHISRILKGRPEGLEKEG----- 7440
Query: 3009 VPPSEG---SSYRL-------RSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKT 3058
PP + +S+RL R+P + TV GQ + C + A W
Sbjct: 7441 -PPRKKPGLASFRLSGLKSWDRAPTFLRELSDETVVLGQSVTLACQVSAQPAA-QATWSK 7498
Query: 3059 RNQELEDNVHIS-----PNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPT 3113
LE + + N ++TI+ + G Y C SNA G + L P+
Sbjct: 7499 DGAPLESSSRVLISATLKNFQLLTILVVVAEDLGVYTCSVSNALGTVTTTGVLRKAERPS 7558
Query: 3114 VSVLPE 3119
S P+
Sbjct: 7559 SSPCPD 7564
Score = 34.7 bits (78), Expect = 2.1
Identities = 30/93 (32%), Positives = 38/93 (40%), Gaps = 8/93 (8%)
Query: 2732 ESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSR-------LRLHHVS 2784
E S V G+++ L C V Q AQ TW K G L S + S L + V
Sbjct: 7468 ELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVV 7527
Query: 2785 PADSGEYVCRVMGSSGPLEAS-VLVTIEASGSS 2816
D G Y C V + G + + VL E SS
Sbjct: 7528 AEDLGVYTCSVSNALGTVTTTGVLRKAERPSSS 7560
Score = 33.9 bits (76), Expect = 3.7
Identities = 18/70 (25%), Positives = 32/70 (45%), Gaps = 1/70 (1%)
Query: 416 IQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
+QA G T +C T + W + + S +V + + G L+++ ++D G
Sbjct: 1360 VQAEAGAIATLSCEVAQAQTEV-TWYKDGKKLSSSSKVRMEAVGCTRRLVVQQACQADTG 1418
Query: 476 AYTCEAMNAR 485
Y+CEA R
Sbjct: 1419 EYSCEAGGQR 1428
Score = 33.5 bits (75), Expect = 4.8
Identities = 19/55 (34%), Positives = 27/55 (49%), Gaps = 1/55 (1%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQG 475
G T F CV + VP ++W N + + RV +++EG R TL I D G
Sbjct: 435 GDTAMF-CVELAVPVGPVHWLRNQEEVVAGGRVAISAEGTRHTLTISQCCLEDVG 488
Score = 33.1 bits (74), Expect = 6.2
Identities = 14/48 (29%), Positives = 22/48 (45%)
Query: 438 INWRLNWGHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNAR 485
+ W + + P+ V + GR L++RDV D G Y C + R
Sbjct: 737 VTWLKDGRTLSPGPKYEVQASAGRRVLLVRDVARDDAGLYECVSRGGR 784
Score = 32.7 bits (73), Expect = 8.2
Identities = 23/71 (32%), Positives = 28/71 (39%), Gaps = 7/71 (9%)
Query: 2346 EPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQT-------HGSLLRLYQAS 2398
E S V GQ++ L C V Q AQ TW K G L + + LL +
Sbjct: 7468 ELSDETVVLGQSVTLACQVSAQPAAQATWSKDGAPLESSSRVLISATLKNFQLLTILVVV 7527
Query: 2399 PADSGEYVCRV 2409
D G Y C V
Sbjct: 7528 AEDLGVYTCSV 7538
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 228 bits (581), Expect = 1e-58
Identities = 203/737 (27%), Positives = 335/737 (45%), Gaps = 96/737 (13%)
Query: 3672 SFLPLPTIKDAYRKFEIKITFRPDS-----ADGMLLYNGQKRVPGSPTNLANRQPDFISF 3726
SFL I D +E + F+ + + ++ + GQK G N DF++
Sbjct: 2428 SFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQK---GHGLN----GDDFLAV 2480
Query: 3727 GLVGGRPEFRFDAGSGMATIR-HPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQG 3785
GL+ G + ++ GSG+A+IR P L+LG HTV L + +G L V D + + G
Sbjct: 2481 GLLNGSVVYSYNLGSGIASIRSEPLNLSLG-VHTVHLGKFFQEGWLKVDDHKNKSIIAPG 2539
Query: 3786 KFQGLDLNEELYLGGYPDY--GAIPK-AGLSSGFIGCVRELRIQGEEIV-FHDL-NLTAH 3840
+ GL++ + Y+GGY +Y +P A +GF GC+ L+++ E+ F L N H
Sbjct: 2540 RLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGH 2599
Query: 3841 -------GISHCPTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQAL----HCH 3889
G H C C NGG C +S +S Y C C G+ GS C + + H
Sbjct: 2600 PNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDP 2658
Query: 3890 PEACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSL-SGAGSYLALPALTNTH 3948
P C ATC++ P GYTC C LG +G+ CE+ ++++ PS S S+++ A +
Sbjct: 2659 PHHCSRGATCISLP--HGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWMSF-ASFHVR 2715
Query: 3949 HELRLDVEFKPLAPDGVLLFSG----GKSGPVEDFVSLAMVGGHLEFRYELGSGLAVLRS 4004
+ + ++F+PLA DG+L ++ +SG DF+ +++V ++ RY LG +L +
Sbjct: 2716 KKTHIQLQFQPLAADGILFYAAQHLKAQSG---DFLCISLVNSSVQLRYNLGDRTIILET 2772
Query: 4005 AEPLAL--GRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGVEPSVP 4062
+ + + WH + A R+ +G L ++G V + K L+ +T Y+GGV
Sbjct: 2773 LQKVTINGSTWHIIKAGRVGAEGYLDLDGIN-VTEKASTKMSSLDTNTDFYIGGVSSLNL 2831
Query: 4063 LSPAT--NMSAHFRGCVGEVSVNGKRLDLT-YSFLGSQGIGQCYDSSPCERQPCQHGATC 4119
++P N F+GC+ +V +N + L LT + G +G C D + C C++G C
Sbjct: 2832 VNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAKGGSNVGDC-DGTACGYNTCRNGGEC 2890
Query: 4120 MPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTR-----CLCLPGFSGPR 4174
G F C C + G+ C ++ L CLH C + CLC G+ G
Sbjct: 2891 TVNGT-TFSCRCLPDWAGNTC--NQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRY 2947
Query: 4175 CQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAF-PGHVFSRSLPEVPETIELE 4233
C+ + A+ F + ++ + + R+L TI L
Sbjct: 2948 CENKTSFSTAK--------------------FMGNSYIKYIDPNYRMRNLQFT--TISLN 2985
Query: 4234 VRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPINDG-- 4291
T+ GL++W G+ E DF+++GL + L LG R+ N+G
Sbjct: 2986 FSTTKTEGLIVWMGIAQNEE---NDFLAIGLHNQTLKIAVNLGE---RISVPMSYNNGTF 3039
Query: 4292 ---EWHRVTALREGRRGSIQVDGEELVS-GRSPGPN-VAVNAKGSVYIGG---APDVATL 4343
+WH V ++ ++ ++S P N VA+N G Y+GG V +
Sbjct: 3040 CCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIV 3099
Query: 4344 TGGRFSSGITGCVKNLV 4360
T F + G +K++V
Sbjct: 3100 TQEIFKTNFVGKIKDVV 3116
Score = 207 bits (527), Expect = 2e-52
Identities = 199/776 (25%), Positives = 331/776 (42%), Gaps = 113/776 (14%)
Query: 3672 SFLPLPTIK-----DAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQPDFISF 3726
S+L LP +K + R I +T + +S +G +LY+ N N F+
Sbjct: 2154 SYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYS----------NGNNCGKQFLHL 2203
Query: 3727 GLVGGRPEFRFDAGSG--MATIRHPTPLALGHFHTVTLLRSLTQGSLIVGDLAPVNGTSQ 3784
LV GRP ++ G+ + T+ + F +T+ + GS G + + T+
Sbjct: 2204 FLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVGS--PGVVCMIEMTAD 2261
Query: 3785 GK--FQGLDLN---------EELYLGGYPDYGAI-PKAGLSSGFIGCVRELRIQGEEIVF 3832
GK Q D E ++LG P I KAG GF GC+ +L++ +E
Sbjct: 2262 GKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFI 2321
Query: 3833 HDLNLTAHGISHC--PTCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHP 3890
D I +C P C C+N G C S++ + C CP ++G C+ + C
Sbjct: 2322 IDEARHGKNIENCHVPWCAHHLCRNNGTCI-SDNENLFCECPRLYSGKLCQFAS---CEN 2377
Query: 3891 EACGPDATCVNRPDGRGYTCRCHLGRSGLRCEEGVTVTTPSLSGAG-----SYLALPALT 3945
CG ATCV + G C C GRSG C + + +T P SG S+LA ++
Sbjct: 2378 NPCGNGATCVPK-SGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRIS 2436
Query: 3946 NT--HHELRLDVEFK---PLAPDGVLLFSGGKSGPV--EDFVSLAMVGGHLEFRYELGSG 3998
+ H+E L + + ++ F+G K + +DF+++ ++ G + + Y LGSG
Sbjct: 2437 DISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSG 2496
Query: 3999 LAVLRSAEPLALGRW-HRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLHTLLYLGGV 4057
+A +RS EPL L H V + ++G L+V+ + +PG+ GLN+ + Y+GG
Sbjct: 2497 IASIRS-EPLNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGY 2555
Query: 4058 EPSVP--LSPATNMSAHFRGCVGEVSVNGKRLDLTYSFLGS--------QGIGQCYDSSP 4107
P L + F+GC+ + V ++ D + LG+ + +GQC+ +SP
Sbjct: 2556 SEYTPDLLPNGADFKNGFQGCIFTLQVRTEK-DGHFRGLGNPEGHPNAGRSVGQCH-ASP 2613
Query: 4108 CERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREP----CLHGGTC---- 4159
C C +G TC+ +G + C C G+KG C + C C G TC
Sbjct: 2614 CSLMKCGNGGTCIESGTSVY-CNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLP 2672
Query: 4160 QGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVF 4219
G C C G +G C+Q I++ + N+ A FH
Sbjct: 2673 HGYTCFCPLGTTGIYCEQALS--ISDPSFR-----SNELSWMSFASFH------------ 2713
Query: 4220 SRSLPEVPETIELEVRTSTASGLLLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGE 4279
I+L+ + A G+L + + Q DF+ + L + + RY LG
Sbjct: 2714 ----VRKKTHIQLQFQPLAADGILFYAAQHL--KAQSGDFLCISLVNSSVQLRYNLGDRT 2767
Query: 4280 ARL--VSEDPINDGEWHRVTALREGRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGGA 4337
L + + IN WH + A R G G + +DG V+ ++ +++ YIGG
Sbjct: 2768 IILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGIN-VTEKASTKMSSLDTNTDFYIGGV 2826
Query: 4338 PDVATLTGGRFSS---GITGCVKNLVLHSARPGAPPPQPLDL-QHRAQAGANTRPC 4389
+ + + G GC++ +++++ Q L L + A+ G+N C
Sbjct: 2827 SSLNLVNPMAIENEPVGFQGCIRQVIINN--------QELQLTEFGAKGGSNVGDC 2874
Score = 116 bits (290), Expect = 6e-25
Identities = 151/610 (24%), Positives = 242/610 (39%), Gaps = 72/610 (11%)
Query: 3796 LYLGGYPD-YGAIPKAGLSSGFIGCVRELRIQGEEIV--------FHDLNLTAHGISHCP 3846
+++GG+PD +G I F GC+ + I +H N + G P
Sbjct: 2013 VFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQGFMLSP 2072
Query: 3847 TCRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGR 3906
T + Q D+ +S V P+ S C+ + C TC
Sbjct: 2073 TASFVDASDVTQGVDTMWTS---VSPSVAAPSVCQQ--------DVCHNGGTCHAIFLSS 2121
Query: 3907 G---YTCRCHLGRSGLRCEEGVTVTTPSLSGAGSYLALP----ALTNTHHE-LRLDVEFK 3958
G + C C L +G CE+ + PS +G SYL LP L H+ + + + K
Sbjct: 2122 GIVSFQCDCPLHFTGRFCEKDAGLFFPSFNG-NSYLELPFLKFVLEKEHNRTVTIYLTIK 2180
Query: 3959 PLAPDGVLLFSGGKSGPVEDFVSLAMVGGHLEFRYELGSGLAVL----------RSAEPL 4008
+ +G +L+S G + + F+ L +V G +Y G+ +L + P+
Sbjct: 2181 TNSLNGTILYSNGNNCG-KQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPI 2239
Query: 4009 ALGRWHRVSAERLNKDGSLRVNGGRPVLRSSPGKSQGLNLH-TLLYLGGVEPSVPLSPAT 4067
+ V + + + +G PV + S + ++LG + +V +
Sbjct: 2240 TIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKA 2299
Query: 4068 NMSAHFRGCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEF 4127
FRGC+ ++ VN K + + I C+ C C++ TC+ E F
Sbjct: 2300 GPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPW-CAHHLCRNNGTCISDNENLF 2358
Query: 4128 QCLCRDGFKGDLCEHEENPCQLREPCLHGGTC---QGTR--CLCLPGFSGPRCQQGSGHG 4182
C C + G LC+ C+ PC +G TC GT CLC G SGP C
Sbjct: 2359 -CECPRLYSGKLCQFAS--CE-NNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAIN-- 2412
Query: 4183 IAESDWHLEGSGGNDAPGQYGAYFHDDGFLAFPGHVFSRSLPEVPETIELEVRTSTASGL 4242
I + + G DA G FLA+ E +L S
Sbjct: 2413 ITQPRF-----SGTDAFGY-------TSFLAYSRISDISFHYEFHLKFQLANNHSALQNN 2460
Query: 4243 LLWQGVEVGEAGQGKDFISLGLQDGHLVFRYQLGSGEARLVSEDPIN-DGEWHRVTALRE 4301
L++ + G G DF+++GL +G +V+ Y LGSG A + SE P+N H V +
Sbjct: 2461 LIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSE-PLNLSLGVHTVHLGKF 2519
Query: 4302 GRRGSIQVDGEELVSGRSPGPNVAVNAKGSVYIGG----APDVATLTGGRFSSGITGCVK 4357
+ G ++VD + S +PG V +N Y+GG PD+ G F +G GC+
Sbjct: 2520 FQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLP-NGADFKNGFQGCIF 2578
Query: 4358 NLVLHSARPG 4367
L + + + G
Sbjct: 2579 TLQVRTEKDG 2588
Score = 63.5 bits (153), Expect = 4e-09
Identities = 58/233 (24%), Positives = 84/233 (36%), Gaps = 45/233 (19%)
Query: 1125 QCSCPPGYRGPSCQ----DCDTGYTRTPSGLYLGTCER--CSCHG--HSEACEPETGAC- 1175
+C C PG+ G C+ +C + + +G + R C+C H CE + C
Sbjct: 913 RCICRPGFSGSLCEIEINECSSEPCKN-NGTCVDLTNRFFCNCEPEYHGPFCELDVNKCK 971
Query: 1176 -------QGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDT 1228
+ C + T+G C C PGY G +C PC D +D
Sbjct: 972 ISPCLDEENCVYRTDGYNC-LCAPGYTGINCEINLDECLSEPCLHDGVC--------IDG 1022
Query: 1229 DGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCD 1288
H TCD C G G HCE A NP C +++ C+CD G+
Sbjct: 1023 INHYTCD-CKSGFFGTHCETNANDCLSNPCLHGRC---TELINEYPCSCDADGT------ 1072
Query: 1289 AAGQCQCKAQVEGLTCSHCRPHHFHLSASN------PDGCLPCFCMGITQQCA 1335
QCK ++ T C F +++ P G +C CA
Sbjct: 1073 ---STQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCA 1122
Score = 59.3 bits (142), Expect = 8e-08
Identities = 27/68 (39%), Positives = 33/68 (48%), Gaps = 5/68 (7%)
Query: 4113 CQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQ----GTRCLCLP 4168
C +G C+ + F C C GF G CE N C PCLHG C+ G C C P
Sbjct: 1131 CLNGGICVDGPGHTFDCRCLPGFSGQFCEININECS-SSPCLHGADCEDHINGYVCKCQP 1189
Query: 4169 GFSGPRCQ 4176
G+SG C+
Sbjct: 1190 GWSGHHCE 1197
Score = 58.2 bits (139), Expect = 2e-07
Identities = 34/114 (29%), Positives = 54/114 (47%), Gaps = 10/114 (8%)
Query: 4095 GSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCL 4154
G GI D C C+H +TC +QC+C ++G+ CE E N C++ PC
Sbjct: 724 GYVGIRCEQDIDDCILNACEHNSTCKDL-HLSYQCVCLSDWEGNFCEQESNECKM-NPCK 781
Query: 4155 HGGTC----QGTRCLCLPGFSGPRCQQGSGHGIAESDWHLEGSGGNDA--PGQY 4202
+ TC + RC C G++G C + +SD + G +++ PGQ+
Sbjct: 782 NNSTCTDLYKSYRCECTSGWTGQNCSEEINE--CDSDPCMNGGLCHESTIPGQF 833
Score = 57.8 bits (138), Expect = 2e-07
Identities = 35/94 (37%), Positives = 45/94 (47%), Gaps = 8/94 (8%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPE----ACGPDATCVNRP 3903
C PC N G C S + + C+CP G+TG+ CE S PE C CV+ P
Sbjct: 1083 CTSIPCMNEGFCQKS-AHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGP 1141
Query: 3904 DGRGYTCRCHLGRSGLRCEEGVT--VTTPSLSGA 3935
G + CRC G SG CE + ++P L GA
Sbjct: 1142 -GHTFDCRCLPGFSGQFCEININECSSSPCLHGA 1174
Score = 56.2 bits (134), Expect = 7e-07
Identities = 26/80 (32%), Positives = 42/80 (52%), Gaps = 8/80 (10%)
Query: 4104 DSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTR 4163
+S+ C+ PC++ +TC + ++C C G+ G C E N C +PC++GG C +
Sbjct: 771 ESNECKMNPCKNNSTCTDLYK-SYRCECTSGWTGQNCSEEINECD-SDPCMNGGLCHEST 828
Query: 4164 ------CLCLPGFSGPRCQQ 4177
CLC P ++G C Q
Sbjct: 829 IPGQFVCLCPPLYTGQFCHQ 848
Score = 55.8 bits (133), Expect = 9e-07
Identities = 32/106 (30%), Positives = 49/106 (46%), Gaps = 5/106 (4%)
Query: 4075 GCVGEVSVNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDG 4134
G E ++ G+ + L Q Q Y+ PC++ +TC+ + C+CR+
Sbjct: 822 GLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREE 881
Query: 4135 FKGDLCEHEENPCQLREPCLHGGTCQ----GTRCLCLPGFSGPRCQ 4176
F+G CE + C L C G C+ RC+C PGFSG C+
Sbjct: 882 FEGKNCEIDVKDC-LFLSCQDYGDCEDMVNNFRCICRPGFSGSLCE 926
Score = 55.8 bits (133), Expect = 9e-07
Identities = 36/142 (25%), Positives = 53/142 (37%), Gaps = 30/142 (21%)
Query: 4076 CVGEVSVNGKRLDLTYS---FLGSQGIGQCYDS---------------------SPCERQ 4111
C+ GK ++ FL Q G C D + C +
Sbjct: 876 CICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSE 935
Query: 4112 PCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTC----QGTRCLCL 4167
PC++ TC+ F C C + G CE + N C++ PCL C G CLC
Sbjct: 936 PCKNNGTCVDLTN-RFFCNCEPEYHGPFCELDVNKCKI-SPCLDEENCVYRTDGYNCLCA 993
Query: 4168 PGFSGPRCQQGSGHGIAESDWH 4189
PG++G C+ ++E H
Sbjct: 994 PGYTGINCEINLDECLSEPCLH 1015
Score = 53.5 bits (127), Expect = 4e-06
Identities = 33/97 (34%), Positives = 44/97 (45%), Gaps = 19/97 (19%)
Query: 4101 QC-YDSSPCERQPCQHGATCMPA-GEY------------EFQCLCRDGFKGDLCEHEENP 4146
QC D C PC++GATC+ G Y F CLC G+ G CE + +
Sbjct: 677 QCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDD 736
Query: 4147 CQLREPCLHGGTCQ----GTRCLCLPGFSGPRCQQGS 4179
C L C H TC+ +C+CL + G C+Q S
Sbjct: 737 CIL-NACEHNSTCKDLHLSYQCVCLSDWEGNFCEQES 772
Score = 50.8 bits (120), Expect = 3e-05
Identities = 36/133 (27%), Positives = 56/133 (42%), Gaps = 13/133 (9%)
Query: 1530 CRCPPGYIGLSCQ----DC---APGYTRTGSGLYLGHCELCECNGHSDLCHPETGAC--S 1580
C C PGY+G+ C+ DC A + T L+L + +C + + C E+ C +
Sbjct: 719 CLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMN 778
Query: 1581 QCQHNAAGEFCELCAPGYYGDATAG-TPEDCQPCACPLTNPENMFSRTCESLGAGGYRCT 1639
C++N+ C Y + T+G T ++C + M C G
Sbjct: 779 PCKNNST---CTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVC 835
Query: 1640 ACEPGYTGQYCEQ 1652
C P YTGQ+C Q
Sbjct: 836 LCPPLYTGQFCHQ 848
Score = 50.4 bits (119), Expect = 4e-05
Identities = 30/92 (32%), Positives = 40/92 (43%), Gaps = 20/92 (21%)
Query: 4104 DSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTC---- 4159
D+ C+ C++G T Y F+ C GFKG CE + + C PC +G TC
Sbjct: 643 DTEDCKSASCKNGTTSTHLRGYFFR-KCVPGFKGTQCEIDIDECA-SHPCKNGATCIDQP 700
Query: 4160 --------------QGTRCLCLPGFSGPRCQQ 4177
G CLC PG+ G RC+Q
Sbjct: 701 GNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQ 732
Score = 50.1 bits (118), Expect = 5e-05
Identities = 35/116 (30%), Positives = 48/116 (41%), Gaps = 11/116 (9%)
Query: 4083 NGKRLDLTYSFLGS-----QGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKG 4137
NG +DLT F + G D + C+ PC C+ + + CLC G+ G
Sbjct: 940 NGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTD-GYNCLCAPGYTG 998
Query: 4138 DLCEHEENPCQLREPCLHGGTC----QGTRCLCLPGFSGPRCQQGSGHGIAESDWH 4189
CE + C L EPCLH G C C C GF G C+ + ++ H
Sbjct: 999 INCEINLDEC-LSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLH 1053
Score = 48.9 bits (115), Expect = 1e-04
Identities = 26/75 (34%), Positives = 34/75 (45%), Gaps = 4/75 (5%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRG 3907
C PC+N G C D ++ + C C + G CE C C + CV R D G
Sbjct: 932 CSSEPCKNNGTCVDL-TNRFFCNCEPEYHGPFCE-LDVNKCKISPCLDEENCVYRTD--G 987
Query: 3908 YTCRCHLGRSGLRCE 3922
Y C C G +G+ CE
Sbjct: 988 YNCLCAPGYTGINCE 1002
Score = 48.9 bits (115), Expect = 1e-04
Identities = 31/90 (34%), Positives = 40/90 (44%), Gaps = 13/90 (14%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRG 3907
C PC +G C D + YVC C G++G CE+ L C P +C + N P G
Sbjct: 1165 CSSSPCLHGADCED-HINGYVCKCQPGWSGHHCENE--LECIPNSCVHELCMENEP---G 1218
Query: 3908 YTCRCHLG----RSGLRCEE---GVTVTTP 3930
TC C G GL C + +T TP
Sbjct: 1219 STCLCTPGFMTCSIGLLCGDEIRRITCLTP 1248
Score = 48.5 bits (114), Expect = 1e-04
Identities = 35/119 (29%), Positives = 49/119 (41%), Gaps = 19/119 (15%)
Query: 4108 CERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLRE----PCLHGGTC---- 4159
C PC + C + + F C+C G+ G CE + C E CL+GG C
Sbjct: 1083 CTSIPCMNEGFCQKSA-HGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGP 1141
Query: 4160 -QGTRCLCLPGFSGPRCQQGSG--------HGIAESDWHLEGSGGNDAPGQYGAYFHDD 4209
C CLPGFSG C+ HG A+ + H+ G PG G + ++
Sbjct: 1142 GHTFDCRCLPGFSGQFCEININECSSSPCLHG-ADCEDHINGYVCKCQPGWSGHHCENE 1199
Score = 48.5 bits (114), Expect = 1e-04
Identities = 26/70 (37%), Positives = 32/70 (45%), Gaps = 3/70 (4%)
Query: 3853 CQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCRC 3912
C NGG C D ++ C C GF+G CE C C A C + + GY C+C
Sbjct: 1131 CLNGGICVDGPGHTFDCRCLPGFSGQFCE-ININECSSSPCLHGADCEDHIN--GYVCKC 1187
Query: 3913 HLGRSGLRCE 3922
G SG CE
Sbjct: 1188 QPGWSGHHCE 1197
Score = 47.0 bits (110), Expect = 4e-04
Identities = 27/78 (34%), Positives = 36/78 (46%), Gaps = 5/78 (6%)
Query: 3848 CRDRPCQNGGQCHDSE-SSSYVCVCPAGFTGSRCEHSQALHCH--PEACGPDATCVNRPD 3904
C PC NGG CH+S +VC+CP +TG C H + C C ++TC+ D
Sbjct: 813 CDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFC-HQRYNLCDLLHNPCRNNSTCLALVD 871
Query: 3905 GRGYTCRCHLGRSGLRCE 3922
+ C C G CE
Sbjct: 872 ANQH-CICREEFEGKNCE 888
Score = 46.6 bits (109), Expect = 5e-04
Identities = 48/180 (26%), Positives = 60/180 (33%), Gaps = 40/180 (22%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGP 790
C C G+SG CE + CS C + + D NC+ GP
Sbjct: 914 CICRPGFSGSLCEI------------EINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGP 961
Query: 791 QCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRR 850
C + C+ PC +D + C TDG C CAPGYTG
Sbjct: 962 FC------------ELDVNKCKISPC--LD-----EENCVYRTDGY-NC-LCAPGYTGIN 1000
Query: 851 CESCAPGYEGNPIQPGGKC-RPVNQEIVRCDERGSMGTSGEACRCKNNVVGRLCNECADG 909
CE P G C +N C + G GT C+ N L N C G
Sbjct: 1001 CEINLDECLSEPCLHDGVCIDGINHYTCDC-KSGFFGT-----HCETNANDCLSNPCLHG 1054
Score = 46.2 bits (108), Expect = 7e-04
Identities = 30/90 (33%), Positives = 39/90 (43%), Gaps = 8/90 (8%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDG-R 3906
C+ PC + C + Y C+C G+TG CE + C E C D C+ DG
Sbjct: 970 CKISPCLDEENCV-YRTDGYNCLCAPGYTGINCEINLD-ECLSEPCLHDGVCI---DGIN 1024
Query: 3907 GYTCRCHLGRSGLRCEEGVT--VTTPSLSG 3934
YTC C G G CE ++ P L G
Sbjct: 1025 HYTCDCKSGFFGTHCETNANDCLSNPCLHG 1054
Score = 46.2 bits (108), Expect = 7e-04
Identities = 24/62 (38%), Positives = 29/62 (46%), Gaps = 2/62 (3%)
Query: 4095 GSQGIGQCYDSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCL 4154
G GI + C +PC H C+ G + C C+ GF G CE N C L PCL
Sbjct: 995 GYTGINCEINLDECLSEPCLHDGVCID-GINHYTCDCKSGFFGTHCETNANDC-LSNPCL 1052
Query: 4155 HG 4156
HG
Sbjct: 1053 HG 1054
Score = 45.4 bits (106), Expect = 0.001
Identities = 48/209 (22%), Positives = 76/209 (36%), Gaps = 38/209 (18%)
Query: 1125 QCSCPPGYRGPSC----QDCDTGYTRTPSGLYLGTCERCSCHG----HSEACEPETGACQ 1176
+CSC Y G C C ++ + GL L C+C G CE +T C+
Sbjct: 589 RCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSGLQRYERNICEIDTEDCK 648
Query: 1177 G--CQH-----HTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTD 1229
C++ H G +C PG+ +GT + + C P A TC +D
Sbjct: 649 SASCKNGTTSTHLRGYFFRKCVPGF-----KGTQCEIDIDECASHPCKNGA--TC-IDQP 700
Query: 1230 GHPTCDA-------------CSPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCN 1276
G+ C C+PG+ G CE+ N + +D + C
Sbjct: 701 GNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCL 760
Query: 1277 CDPQGSVSSQCDAAGQCQCKAQVEGLTCS 1305
D +G+ Q + +C+ TC+
Sbjct: 761 SDWEGNFCEQ--ESNECKMNPCKNNSTCT 787
Score = 44.3 bits (103), Expect = 0.003
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 6/89 (6%)
Query: 3853 CQNGGQC-HDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRP---DGRGY 3908
C G+C ++ S +Y C C F+G C+ A C + C + +C+N+ D + Y
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA--CSFKPCKNNGSCINKRENWDEQAY 240
Query: 3909 TCRCHLGRSGLRCEEGVTVTTPSLSGAGS 3937
C CH +G C E + P + G+
Sbjct: 241 ECVCHPPFTGKNCSEIIGQCQPHVCFHGN 269
Score = 43.5 bits (101), Expect = 0.005
Identities = 24/83 (28%), Positives = 34/83 (40%), Gaps = 9/83 (10%)
Query: 4102 CYDSSPCERQPCQHGATCMPA----GEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGG 4157
C + C +PC++ +C+ E ++C+C F G C CQ C HG
Sbjct: 211 CQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ-PHVCFHGN 269
Query: 4158 ----TCQGTRCLCLPGFSGPRCQ 4176
T C C FSGP C+
Sbjct: 270 CSNITSNSFICECDEQFSGPFCE 292
Score = 43.1 bits (100), Expect = 0.006
Identities = 45/165 (27%), Positives = 59/165 (35%), Gaps = 45/165 (27%)
Query: 1525 LEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCE--------LCECNGHSDLCHPET 1576
++V++C + LSCQD G CE +C LC E
Sbjct: 889 IDVKDC------LFLSCQD-------------YGDCEDMVNNFRCICRPGFSGSLCEIEI 929
Query: 1577 GACSQ--CQHNAAGE------FCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTC 1628
CS C++N FC C P Y+G C+ C + EN RT
Sbjct: 930 NECSSEPCKNNGTCVDLTNRFFCN-CEPEYHGPFCELDVNKCKISPC--LDEENCVYRT- 985
Query: 1629 ESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLPETN 1673
GY C C PGYTG CE + P + G C+ N
Sbjct: 986 -----DGYNCL-CAPGYTGINCEINLDECLSEPCLHDGVCIDGIN 1024
Score = 42.7 bits (99), Expect = 0.008
Identities = 47/194 (24%), Positives = 67/194 (34%), Gaps = 44/194 (22%)
Query: 1530 CRCPPGYIGLSCQ----DCAPGYTRTGSGLYLGHCELCECN--GHSDLCHPETGACSQ-- 1581
C C G+ G C+ DC G L + C C+ G S C + C+
Sbjct: 1028 CDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIP 1087
Query: 1582 ------CQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGG 1635
CQ +A G C +C GY G A + CA P N + G G
Sbjct: 1088 CMNEGFCQKSAHGFTC-ICPRGYTG---AYCEKSIDNCAEPELNSVICLNGGICVDGPGH 1143
Query: 1636 YRCTACEPGYTGQYCE--------------------------QCGPGYVGNPSVQGGQCL 1669
C PG++GQ+CE +C PG+ G+ +C+
Sbjct: 1144 TFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECI 1203
Query: 1670 PETNQAPLVVEVHP 1683
P + L +E P
Sbjct: 1204 PNSCVHELCMENEP 1217
Score = 42.4 bits (98), Expect = 0.010
Identities = 23/78 (29%), Positives = 36/78 (46%), Gaps = 4/78 (5%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRG 3907
C C++ C D S Y CVC + + G+ CE ++ C C ++TC + +
Sbjct: 737 CILNACEHNSTCKDLHLS-YQCVCLSDWEGNFCE-QESNECKMNPCKNNSTCTDL--YKS 792
Query: 3908 YTCRCHLGRSGLRCEEGV 3925
Y C C G +G C E +
Sbjct: 793 YRCECTSGWTGQNCSEEI 810
Score = 42.0 bits (97), Expect = 0.013
Identities = 25/79 (31%), Positives = 31/79 (39%), Gaps = 7/79 (8%)
Query: 3848 CRDRPCQNGGQCHDS----ESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRP 3903
C +PC+N G C + + +Y CVC FTG C C P C C N
Sbjct: 217 CSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIG-QCQPHVCF-HGNCSN-I 273
Query: 3904 DGRGYTCRCHLGRSGLRCE 3922
+ C C SG CE
Sbjct: 274 TSNSFICECDEQFSGPFCE 292
Score = 41.2 bits (95), Expect = 0.023
Identities = 24/90 (26%), Positives = 38/90 (42%), Gaps = 14/90 (15%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGR- 3906
C+ C+NG + C GF G++CE C C ATC+++P
Sbjct: 647 CKSASCKNGTTSTHLRGY-FFRKCVPGFKGTQCE-IDIDECASHPCKNGATCIDQPGNYF 704
Query: 3907 -----------GYTCRCHLGRSGLRCEEGV 3925
G++C C+ G G+RCE+ +
Sbjct: 705 CQCVPPFKVVDGFSCLCNPGYVGIRCEQDI 734
Score = 40.8 bits (94), Expect = 0.030
Identities = 41/155 (26%), Positives = 57/155 (36%), Gaps = 21/155 (13%)
Query: 1525 LEVEECR---CPPGYI-----GLSCQDCAPGYTRTGSGLYLGHCELCEC-NGHSDLCHPE 1575
++ E+C+ C G G + C PG+ T + + C C NG + + P
Sbjct: 642 IDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPG 701
Query: 1576 TGACSQC--QHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGA 1633
C QC F LC PGY G +DC AC + TC+ L
Sbjct: 702 NYFC-QCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACE-------HNSTCKDLHL 753
Query: 1634 GGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQC 1668
Y+C C + G +CEQ NP C
Sbjct: 754 -SYQC-VCLSDWEGNFCEQESNECKMNPCKNNSTC 786
Score = 40.4 bits (93), Expect = 0.039
Identities = 23/78 (29%), Positives = 35/78 (44%), Gaps = 7/78 (8%)
Query: 4104 DSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQ--- 4160
+++ C PC HG EY C C C+ + N C PC++ G CQ
Sbjct: 1042 NANDCLSNPCLHGRCTELINEY--PCSCDADGTSTQCKIKINDC-TSIPCMNEGFCQKSA 1098
Query: 4161 -GTRCLCLPGFSGPRCQQ 4177
G C+C G++G C++
Sbjct: 1099 HGFTCICPRGYTGAYCEK 1116
Score = 40.0 bits (92), Expect = 0.051
Identities = 21/72 (29%), Positives = 31/72 (43%), Gaps = 11/72 (15%)
Query: 4115 HGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTC---------QGTRCL 4165
HG A + C C+ F G C+ E + C + PC + G+C Q C+
Sbjct: 186 HGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDACSFK-PCKNNGSCINKRENWDEQAYECV 243
Query: 4166 CLPGFSGPRCQQ 4177
C P F+G C +
Sbjct: 244 CHPPFTGKNCSE 255
Score = 39.7 bits (91), Expect = 0.067
Identities = 22/82 (26%), Positives = 35/82 (42%), Gaps = 6/82 (7%)
Query: 4104 DSSPCERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLREPCLHGGTCQGTR 4163
D S PCQ+G C+ + C+C F LC+ + C+ P + TC+
Sbjct: 332 DVSEFSLVPCQNGTDCIKISN-DVMCICSPIFTDLLCKSIQTSCE-SFPLRNNATCKKCE 389
Query: 4164 ----CLCLPGFSGPRCQQGSGH 4181
C C+ GF+ C++ H
Sbjct: 390 KDYPCSCISGFTEKNCEKAIDH 411
Score = 39.3 bits (90), Expect = 0.087
Identities = 21/76 (27%), Positives = 30/76 (39%), Gaps = 2/76 (2%)
Query: 3848 CRDRPCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRG 3907
C+ PC+N C D S Y C C +G+TG C + C + C C
Sbjct: 775 CKMNPCKNNSTCTDLYKS-YRCECTSGWTGQNCS-EEINECDSDPCMNGGLCHESTIPGQ 832
Query: 3908 YTCRCHLGRSGLRCEE 3923
+ C C +G C +
Sbjct: 833 FVCLCPPLYTGQFCHQ 848
Score = 38.9 bits (89), Expect = 0.11
Identities = 38/139 (27%), Positives = 50/139 (35%), Gaps = 28/139 (20%)
Query: 1530 CRCPPGYIGLSCQ----DCAP------GYTRTGSGLYLGHCEL------CECNGHSDLCH 1573
C C PGY G++C+ +C G G Y C+ CE N + L +
Sbjct: 990 CLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSN 1049
Query: 1574 PETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGA 1633
P C H E D GT C+ T+ M C+ A
Sbjct: 1050 P-------CLHGRCTELINEYPCSCDAD---GTSTQCKIKINDCTSIPCMNEGFCQK-SA 1098
Query: 1634 GGYRCTACEPGYTGQYCEQ 1652
G+ C C GYTG YCE+
Sbjct: 1099 HGFTCI-CPRGYTGAYCEK 1116
Score = 37.4 bits (85), Expect = 0.33
Identities = 52/227 (22%), Positives = 81/227 (35%), Gaps = 48/227 (21%)
Query: 732 RCPIGYSGLSCE----SCDAHFTRVPG------GPYLGTCS---------GCNCN-GHAS 771
+C G+ G CE C +H + G Y C C CN G+
Sbjct: 668 KCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVG 727
Query: 772 -SCDPVYGHCL--NCQHNTE------GPQCNKCKAGFFGDAMKATATSCRPCPCPYIDAS 822
C+ C+ C+HN+ QC C + + G+ + + C+ PC
Sbjct: 728 IRCEQDIDDCILNACEHNSTCKDLHLSYQC-VCLSDWEGNFCEQESNECKMNPC------ 780
Query: 823 RRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRP---VNQEIVRC 879
+ + TC D C+ C G+TG+ C + +P GG C Q + C
Sbjct: 781 -KNNSTC-TDLYKSYRCE-CTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLC 837
Query: 880 DERGSMGTSGEACRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFC 926
+G+ C + N+ L N C + S L+ D C C
Sbjct: 838 PPL----YTGQFCHQRYNLCDLLHNPCRNNSTCLAL--VDANQHCIC 878
Score = 37.4 bits (85), Expect = 0.33
Identities = 48/206 (23%), Positives = 69/206 (33%), Gaps = 64/206 (31%)
Query: 1126 CSCPPGYRGPSC-QDCDTGYTRTPSGLYLGTCERCSCHGHSEACEPETGACQG-CQHHTE 1183
C C PGY G C QD D L CE H+ C+ + Q C E
Sbjct: 719 CLCNPGYVGIRCEQDIDD--------CILNACE------HNSTCKDLHLSYQCVCLSDWE 764
Query: 1184 GPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPT--CDACSPGH 1241
G CEQ +C++ PC + TC TD + + C+ C+ G
Sbjct: 765 GNFCEQ------------ESNECKMNPCKNNS-------TC---TDLYKSYRCE-CTSGW 801
Query: 1242 SGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDP---------------------- 1279
+G++C +P +S +PG C C P
Sbjct: 802 TGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCR 861
Query: 1280 -QGSVSSQCDAAGQCQCKAQVEGLTC 1304
+ + DA C C+ + EG C
Sbjct: 862 NNSTCLALVDANQHCICREEFEGKNC 887
Score = 37.4 bits (85), Expect = 0.33
Identities = 51/206 (24%), Positives = 68/206 (33%), Gaps = 58/206 (28%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGP 790
C C GY+G++CE L C C D + H T
Sbjct: 990 CLCAPGYTGINCEI------------NLDECLSEPCLHDGVCIDGI-------NHYT--- 1027
Query: 791 QCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSD-TCFLDTDGQAT----------- 838
C+ CK+GFFG + A C PC + + ++ C D DG +T
Sbjct: 1028 -CD-CKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTS 1085
Query: 839 --------CDACAPGYTGRRCESCAPGYEGNPIQPG-GKCRPVNQEIVRCDERGSMGTSG 889
C A G+T C C GY G + C V C G + G
Sbjct: 1086 IPCMNEGFCQKSAHGFT---C-ICPRGYTGAYCEKSIDNCAEPELNSVIC-LNGGICVDG 1140
Query: 890 EA----CRCKNNVVGRLC----NECA 907
CRC G+ C NEC+
Sbjct: 1141 PGHTFDCRCLPGFSGQFCEININECS 1166
Score = 36.6 bits (83), Expect = 0.56
Identities = 24/83 (28%), Positives = 32/83 (38%), Gaps = 6/83 (7%)
Query: 1516 PGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPE 1575
PG S + + + EC P G C+D GY + GH C + C P
Sbjct: 1151 PGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGH----HCENELE-CIPN 1205
Query: 1576 TGACSQCQHNAAGEFCELCAPGY 1598
+ C N G C LC PG+
Sbjct: 1206 SCVHELCMENEPGSTC-LCTPGF 1227
Score = 35.4 bits (80), Expect = 1.3
Identities = 34/150 (22%), Positives = 49/150 (32%), Gaps = 42/150 (28%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNG----HASSCDPVYGHCLNCQHN 786
C CP GY+G CE + C+ N + C GH +C
Sbjct: 1103 CICPRGYTGAYCEKS------------IDNCAEPELNSVICLNGGICVDGPGHTFDC--- 1147
Query: 787 TEGPQCNKCKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGY 846
+C GF G + C PC + C +G C PG+
Sbjct: 1148 -------RCLPGFSGQFCEININECSSSPCLH-------GADCEDHINGYVC--KCQPGW 1191
Query: 847 TGRRCES---CAPGYEGNPI----QPGGKC 869
+G CE+ C P + + +PG C
Sbjct: 1192 SGHHCENELECIPNSCVHELCMENEPGSTC 1221
Score = 34.7 bits (78), Expect = 2.1
Identities = 22/73 (30%), Positives = 33/73 (45%), Gaps = 6/73 (8%)
Query: 4108 CERQPCQHGATCMPAGEYEFQCLCRDGFKGDLCEHEENPCQLRE-PCLHGGTCQGT---- 4162
CE P ++ ATC E ++ C C GF CE + C+L CL+ C
Sbjct: 374 CESFPLRNNATCKKC-EKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRF 432
Query: 4163 RCLCLPGFSGPRC 4175
+ +C+PG + C
Sbjct: 433 KYVCIPGCTKNPC 445
Score = 34.3 bits (77), Expect = 2.8
Identities = 27/123 (21%), Positives = 44/123 (35%), Gaps = 31/123 (25%)
Query: 1530 CRCPPGYIGLSCQDCAPGYTRTGSGLYLGHCELCECNGHSDLCHPETGACSQCQHNAAGE 1589
C C P + G CQ+ L C C + G+C + N +
Sbjct: 200 CHCQPPFSGKYCQE-------------LDACSFKPCKNN--------GSCINKRENWDEQ 238
Query: 1590 FCE-LCAPGYYGDATAGTPEDCQPCACPLTNPENMFSRTCESLGAGGYRCTACEPGYTGQ 1648
E +C P + G + CQP C F C ++ + + C C+ ++G
Sbjct: 239 AYECVCHPPFTGKNCSEIIGQCQPHVC--------FHGNCSNITSNSFIC-ECDEQFSGP 289
Query: 1649 YCE 1651
+CE
Sbjct: 290 FCE 292
Score = 34.3 bits (77), Expect = 2.8
Identities = 45/171 (26%), Positives = 57/171 (33%), Gaps = 35/171 (20%)
Query: 1121 LEVEQCSCPPGYRGPSCQDCDTGYTRT-PSGLYLGTCERCSCHGHSEACEPET------- 1172
+++ C+ P CQ G+T P G CE+ EPE
Sbjct: 1078 IKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSI----DNCAEPELNSVICLN 1133
Query: 1173 -GACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGH 1231
G C HT RC PG+ G +C PC C +G+
Sbjct: 1134 GGICVDGPGHTFDCRC---LPGFSGQFCEININECSSSPCLHGA-------DCEDHINGY 1183
Query: 1232 PTCDACSPGHSGRHCE---RCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDP 1279
C C PG SG HCE C P N + C + PG C C P
Sbjct: 1184 -VCK-CQPGWSGHHCENELECIP----NSCVHELCMENE--PGST-CLCTP 1225
Score = 33.9 bits (76), Expect = 3.7
Identities = 20/71 (28%), Positives = 28/71 (39%), Gaps = 3/71 (4%)
Query: 3852 PCQNGGQCHDSESSSYVCVCPAGFTGSRCEHSQALHCHPEACGPDATCVNRPDGRGYTCR 3911
PC+N C ++ C+C F G CE C +C C + + + C
Sbjct: 859 PCRNNSTCLALVDANQHCICREEFEGKNCE-IDVKDCLFLSCQDYGDCEDMVN--NFRCI 915
Query: 3912 CHLGRSGLRCE 3922
C G SG CE
Sbjct: 916 CRPGFSGSLCE 926
>gi|157419140 laminin, gamma 2 isoform b precursor [Homo sapiens]
Length = 1111
Score = 225 bits (573), Expect = 9e-58
Identities = 174/599 (29%), Positives = 254/599 (42%), Gaps = 86/599 (14%)
Query: 764 CNCNGHASSCDPVYGH-----------CLNCQHNTEGPQCNKCKAGFFGDAMKATATSCR 812
C+CNG + C ++ CLNC NT+G C KCK GF+ + C
Sbjct: 28 CDCNGKSRQC--IFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRER---DRCL 82
Query: 813 PCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPV 872
PC C ++ S C D C +C PG TG RC+ C PG+ + + +
Sbjct: 83 PCNC---NSKGSLSARC----DNSGRC-SCKPGVTGARCDRCLPGFHMLTDAGCTQDQRL 134
Query: 873 NQEIVRCDERGSMGTSGEA-CRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSR 931
CD G G C CK V G C+ C G ++L NP+GC +CFC G S
Sbjct: 135 LDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSA 194
Query: 932 HCTSSSWSRAQLHGASEEPGHFSLTNAAST-HTTNEGIFSP----TPGELGFSSFHRLLS 986
C SS+ +S+ ST H +G + +P +L +S H+ +
Sbjct: 195 SCRSSA--------------EYSVHKITSTFHQDVDGWKAVQRNGSPAKLQWSQRHQDVF 240
Query: 987 G------PYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPGSTPLHGQPLVVLQGNNIILE 1040
P ++ P++FLG++ SYG L F H V+L+G + +
Sbjct: 241 SSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHD---VILEGAGLRIT 297
Query: 1041 HHV---AQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMALAGIDTLLIRASYAQQP 1097
+ + G T+ E Q + E+ + L + L IRA+Y +
Sbjct: 298 APLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRL-LRNLTALRIRATYGEY- 355
Query: 1098 AESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGL-YLGTC 1156
+ + +++ A P PA VEQC CP GY+G CQDC +GY R + L GTC
Sbjct: 356 STGYIDNVTLISARPVSGA--PAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTC 413
Query: 1157 ERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPA 1216
C+C G AC+P+TG C + + C C G+Y D P+ C+ CPC+ +
Sbjct: 414 IPCNCQG-GGACDPDTGDCYSGDENPD-IECADCPIGFYNDPH--DPRSCKPCPCHNGFS 469
Query: 1217 AGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNP----SQGQPCQRDSQVPGP 1272
T C+ C PG +G CE CA GY+G+P +PCQ P
Sbjct: 470 CSVMPET------EEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQ-------P 516
Query: 1273 IGCNCDPQGSVSSQCD-AAGQC-QCKAQVEGLTCSHCRPHHF--HLSASNPDGCLPCFC 1327
CN + S S CD G+C +C G+ C C+ +F L+ + D C C C
Sbjct: 517 CQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNC 575
Score = 206 bits (524), Expect = 4e-52
Identities = 170/529 (32%), Positives = 233/529 (44%), Gaps = 56/529 (10%)
Query: 1157 ERCSCHGHSEAC------EPETG---ACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQ 1207
E C C+G S C +TG C C +T+G CE+C+ G+Y +R C
Sbjct: 26 EVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDR---CL 82
Query: 1208 LCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDS 1267
C C + G + C D C +C PG +G C+RC PG++ G C +D
Sbjct: 83 PCNCN---SKGSLSARC----DNSGRC-SCKPGVTGARCDRCLPGFHMLTDAG--CTQDQ 132
Query: 1268 QVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
++ C+CDP G ++ CDA G+C CK V G C CR +++L NP+GC CFC
Sbjct: 133 RLLDS-KCDCDPAG-IAGPCDA-GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFC 189
Query: 1328 MGITQQCASSA-YTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGN 1386
G + C SSA Y+ H I++ F D G+ V QRN G + Q F +
Sbjct: 190 YGHSASCRSSAEYSVHKITSTFHQ-DVDGWKAV--QRN----GSPAKLQWSQRHQDVFSS 242
Query: 1387 FAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGNNIMLVA 1446
+L + Y+ P + G++ +YG L + Y G S DV + G + + A
Sbjct: 243 AQRL--DPVYFVAPAKFLGNQQVSYGQSLSF--DYRVDRGGRHPSAHDVILEGAGLRITA 298
Query: 1447 S----QPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSVPL 1502
L ++Y E Q + E+ + L +L L IRAT+
Sbjct: 299 PLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRL-LRNLTALRIRATYGEYS- 356
Query: 1503 AASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGL-YLGHCE 1561
I V+L A+P S P A VE+C CP GY G CQDCA GY R + L G C
Sbjct: 357 TGYIDNVTLISARP-VSGAP-APWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTCI 414
Query: 1562 LCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPE 1621
C C G C P+TG C N E C C G+Y D P C+PC C
Sbjct: 415 PCNCQG-GGACDPDTGDCYSGDENPDIE-CADCPIGFYND--PHDPRSCKPCPCHNGFSC 470
Query: 1622 NMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLP 1670
++ T E + C C PG TG CE C GY G+P + G P
Sbjct: 471 SVMPETEEVV------CNNCPPGVTGARCELCADGYFGDPFGEHGPVRP 513
Score = 159 bits (401), Expect = 8e-38
Identities = 133/441 (30%), Positives = 195/441 (44%), Gaps = 53/441 (12%)
Query: 505 CPDGHFYLE--HSAACLPCFCFGITSVCQSTRRFR-DQIRLRFDQP-DDFKGVNVTMPAQ 560
C G++ L+ + C CFC+G ++ C+S+ + +I F Q D +K V +
Sbjct: 169 CRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQ-----R 223
Query: 561 PGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRY 620
G+P + Q +D ++ P +FLGN+ SYG SL ++ Y
Sbjct: 224 NGSPAKLQWSQRHQDVFSSAQRLD--------PVYFVAPAKFLGNQQVSYGQSLSFD--Y 273
Query: 621 ELARGMLEPVQRPDVVLMGAGYRLLS--RGHTPTQPGALNQRQVQFSEEHWVHESGRPVQ 678
+ RG P DV+L GAG R+ + T P L + EH + +
Sbjct: 274 RVDRGGRHPSAH-DVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLS 332
Query: 679 RAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHA--TSHGRAHSVEECRCPIG 736
E ++L++L A+ I+ Y S G D + T+ A S A VE+C CP+G
Sbjct: 333 YFEYRRLLRNLTALRIRATYGEY--STGYID---NVTLISARPVSGAPAPWVEQCICPVG 387
Query: 737 YSGLSCESCDAHFTRVPG--GPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNK 794
Y G C+ C + + R GP+ GTC CNC G +CDP G C + N + +C
Sbjct: 388 YKGQFCQDCASGYKRDSARLGPF-GTCIPCNCQG-GGACDPDTGDCYSGDENPD-IECAD 444
Query: 795 CKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESC 854
C GF+ D SC+PCPC FS + +T+ + C+ C PG TG RCE C
Sbjct: 445 CPIGFYNDPHDPR--SCKPCPC-----HNGFSCSVMPETE-EVVCNNCPPGVTGARCELC 496
Query: 855 APGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACR-------CKNNVVGRLCNECA 907
A GY G+P G RP + +C+ SG R C +N G C++C
Sbjct: 497 ADGYFGDPFGEHGPVRPC--QPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCK 554
Query: 908 DGSF--HLSTRNPDGCLKCFC 926
G F L+ D C C C
Sbjct: 555 AGYFGDPLAPNPADKCRACNC 575
Score = 86.7 bits (213), Expect = 5e-16
Identities = 51/138 (36%), Positives = 64/138 (46%), Gaps = 16/138 (11%)
Query: 1522 PRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLY--LGHCELCECNGHSDL-----CHP 1574
P EV CPPG G C+ CA GY G + + C+ C+CN + D C
Sbjct: 474 PETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDR 533
Query: 1575 ETGACSQCQHNAAGEFCELCAPGYYGDATAGTPED-CQPCACPLTNPENMFSRTCESLGA 1633
TG C +C HN AG +C+ C GY+GD A P D C+ C C NP C S G
Sbjct: 534 LTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNC---NPMGSEPVGCRSDGT 590
Query: 1634 GGYRCTACEPGYTGQYCE 1651
C+PG+ G CE
Sbjct: 591 -----CVCKPGFGGPNCE 603
Score = 82.4 bits (202), Expect = 9e-15
Identities = 52/144 (36%), Positives = 68/144 (47%), Gaps = 20/144 (13%)
Query: 733 CPIGYSGLSCESCDAHFTRVPGGPY--LGTCSGCNCNGH-----ASSCDPVYGHCLNCQH 785
CP G +G CE C + P G + + C C CN + + +CD + G CL C H
Sbjct: 484 CPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIH 543
Query: 786 NTEGPQCNKCKAGFFGDAMKAT-ATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAP 844
NT G C++CKAG+FGD + A CR C C + S+ +DG TC C P
Sbjct: 544 NTAGIYCDQCKAGYFGDPLAPNPADKCRACNC-----NPMGSEPVGCRSDG--TC-VCKP 595
Query: 845 GYTGRRCE----SCAPGYEGNPIQ 864
G+ G CE SC Y IQ
Sbjct: 596 GFGGPNCEHGAFSCPACYNQVKIQ 619
Score = 80.1 bits (196), Expect = 4e-14
Identities = 47/140 (33%), Positives = 64/140 (45%), Gaps = 22/140 (15%)
Query: 1122 EVEQCSCPPGYRGPSCQDCDTGYTRTPSGLY--LGTCERCSCHGH-----SEACEPETGA 1174
EV +CPPG G C+ C GY P G + + C+ C C+ + S C+ TG
Sbjct: 478 EVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGR 537
Query: 1175 CQGCQHHTEGPRCEQCQPGYYGDAQRGTPQD-CQLCPCY---GDPAAGQAAHTCFLDTDG 1230
C C H+T G C+QC+ GY+GD P D C+ C C +P ++ TC
Sbjct: 538 CLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTC------ 591
Query: 1231 HPTCDACSPGHSGRHCERCA 1250
C PG G +CE A
Sbjct: 592 -----VCKPGFGGPNCEHGA 606
Score = 35.8 bits (81), Expect = 0.96
Identities = 26/95 (27%), Positives = 37/95 (38%), Gaps = 18/95 (18%)
Query: 3847 TCRDRPCQNGGQCHDS-ESSSYVCV-CPAGFTGSRC-------------EHSQALHCHPE 3891
+C+ PC NG C E+ VC CP G TG+RC EH C P
Sbjct: 458 SCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPC 517
Query: 3892 ACGPD---ATCVNRPDGRGYTCRCHLGRSGLRCEE 3923
C + + N G +C +G+ C++
Sbjct: 518 QCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQ 552
Score = 34.7 bits (78), Expect = 2.1
Identities = 15/43 (34%), Positives = 23/43 (53%), Gaps = 1/43 (2%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSC 773
C C +G C+ C + + + GG G C+ C C GH++SC
Sbjct: 155 CVCKPAVTGERCDRCRSGYYNLDGGNPEG-CTQCFCYGHSASC 196
Score = 33.9 bits (76), Expect = 3.7
Identities = 28/119 (23%), Positives = 44/119 (36%), Gaps = 21/119 (17%)
Query: 4082 VNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYE------FQCL----- 4130
V G R +L G+ PC+ C + +G + +C+
Sbjct: 488 VTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAG 547
Query: 4131 -----CRDGFKGD-LCEHEENPCQLREPCLHGGTCQGTR----CLCLPGFSGPRCQQGS 4179
C+ G+ GD L + + C+ G G R C+C PGF GP C+ G+
Sbjct: 548 IYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTCVCKPGFGGPNCEHGA 606
Score = 32.7 bits (73), Expect = 8.2
Identities = 24/86 (27%), Positives = 28/86 (32%), Gaps = 13/86 (15%)
Query: 3847 TCRDRPCQNGGQCHDSESSSY---------VCVCPAGFTGSRCEHSQALHCHPEACGPDA 3897
TC CQ GG C Y CP GF + C P C
Sbjct: 412 TCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYN---DPHDPRSCKPCPCHNGF 468
Query: 3898 TCVNRPDGRGYTC-RCHLGRSGLRCE 3922
+C P+ C C G +G RCE
Sbjct: 469 SCSVMPETEEVVCNNCPPGVTGARCE 494
>gi|157419138 laminin, gamma 2 isoform a precursor [Homo sapiens]
Length = 1193
Score = 225 bits (573), Expect = 9e-58
Identities = 174/599 (29%), Positives = 254/599 (42%), Gaps = 86/599 (14%)
Query: 764 CNCNGHASSCDPVYGH-----------CLNCQHNTEGPQCNKCKAGFFGDAMKATATSCR 812
C+CNG + C ++ CLNC NT+G C KCK GF+ + C
Sbjct: 28 CDCNGKSRQC--IFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRER---DRCL 82
Query: 813 PCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESCAPGYEGNPIQPGGKCRPV 872
PC C ++ S C D C +C PG TG RC+ C PG+ + + +
Sbjct: 83 PCNC---NSKGSLSARC----DNSGRC-SCKPGVTGARCDRCLPGFHMLTDAGCTQDQRL 134
Query: 873 NQEIVRCDERGSMGTSGEA-CRCKNNVVGRLCNECADGSFHLSTRNPDGCLKCFCMGVSR 931
CD G G C CK V G C+ C G ++L NP+GC +CFC G S
Sbjct: 135 LDSKCDCDPAGIAGPCDAGRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFCYGHSA 194
Query: 932 HCTSSSWSRAQLHGASEEPGHFSLTNAAST-HTTNEGIFSP----TPGELGFSSFHRLLS 986
C SS+ +S+ ST H +G + +P +L +S H+ +
Sbjct: 195 SCRSSA--------------EYSVHKITSTFHQDVDGWKAVQRNGSPAKLQWSQRHQDVF 240
Query: 987 G------PYFWSLPSRFLGDKVTSYGGELRFTVTQRSQPGSTPLHGQPLVVLQGNNIILE 1040
P ++ P++FLG++ SYG L F H V+L+G + +
Sbjct: 241 SSAQRLDPVYFVAPAKFLGNQQVSYGQSLSFDYRVDRGGRHPSAHD---VILEGAGLRIT 297
Query: 1041 HHV---AQEPSPGQPSTFIVPFREQAWQRPDGQPATREHLLMALAGIDTLLIRASYAQQP 1097
+ + G T+ E Q + E+ + L + L IRA+Y +
Sbjct: 298 APLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRL-LRNLTALRIRATYGEY- 355
Query: 1098 AESRVSGISMDVAVPEETGQDPALEVEQCSCPPGYRGPSCQDCDTGYTRTPSGL-YLGTC 1156
+ + +++ A P PA VEQC CP GY+G CQDC +GY R + L GTC
Sbjct: 356 STGYIDNVTLISARPVSGA--PAPWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTC 413
Query: 1157 ERCSCHGHSEACEPETGACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQLCPCYGDPA 1216
C+C G AC+P+TG C + + C C G+Y D P+ C+ CPC+ +
Sbjct: 414 IPCNCQG-GGACDPDTGDCYSGDENPD-IECADCPIGFYNDPH--DPRSCKPCPCHNGFS 469
Query: 1217 AGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNP----SQGQPCQRDSQVPGP 1272
T C+ C PG +G CE CA GY+G+P +PCQ P
Sbjct: 470 CSVMPET------EEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQ-------P 516
Query: 1273 IGCNCDPQGSVSSQCD-AAGQC-QCKAQVEGLTCSHCRPHHF--HLSASNPDGCLPCFC 1327
CN + S S CD G+C +C G+ C C+ +F L+ + D C C C
Sbjct: 517 CQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNC 575
Score = 206 bits (524), Expect = 4e-52
Identities = 170/529 (32%), Positives = 233/529 (44%), Gaps = 56/529 (10%)
Query: 1157 ERCSCHGHSEAC------EPETG---ACQGCQHHTEGPRCEQCQPGYYGDAQRGTPQDCQ 1207
E C C+G S C +TG C C +T+G CE+C+ G+Y +R C
Sbjct: 26 EVCDCNGKSRQCIFDRELHRQTGNGFRCLNCNDNTDGIHCEKCKNGFYRHRERDR---CL 82
Query: 1208 LCPCYGDPAAGQAAHTCFLDTDGHPTCDACSPGHSGRHCERCAPGYYGNPSQGQPCQRDS 1267
C C + G + C D C +C PG +G C+RC PG++ G C +D
Sbjct: 83 PCNCN---SKGSLSARC----DNSGRC-SCKPGVTGARCDRCLPGFHMLTDAG--CTQDQ 132
Query: 1268 QVPGPIGCNCDPQGSVSSQCDAAGQCQCKAQVEGLTCSHCRPHHFHLSASNPDGCLPCFC 1327
++ C+CDP G ++ CDA G+C CK V G C CR +++L NP+GC CFC
Sbjct: 133 RLLDS-KCDCDPAG-IAGPCDA-GRCVCKPAVTGERCDRCRSGYYNLDGGNPEGCTQCFC 189
Query: 1328 MGITQQCASSA-YTRHLISTHFAPGDFQGFALVNPQRNSRLTGEFTVEPVPEGAQLSFGN 1386
G + C SSA Y+ H I++ F D G+ V QRN G + Q F +
Sbjct: 190 YGHSASCRSSAEYSVHKITSTFHQ-DVDGWKAV--QRN----GSPAKLQWSQRHQDVFSS 242
Query: 1387 FAQLGHESFYWQLPETYQGDKVAAYGGKLRYTLSYTAGPQGSPLSDPDVQITGNNIMLVA 1446
+L + Y+ P + G++ +YG L + Y G S DV + G + + A
Sbjct: 243 AQRL--DPVYFVAPAKFLGNQQVSYGQSLSF--DYRVDRGGRHPSAHDVILEGAGLRITA 298
Query: 1447 S----QPALQGPERRSYEIMFREEFWRRPDGQPATREHLLMALADLDELLIRATFSSVPL 1502
L ++Y E Q + E+ + L +L L IRAT+
Sbjct: 299 PLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLSYFEYRRL-LRNLTALRIRATYGEYS- 356
Query: 1503 AASISAVSLEVAQPGPSNRPRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGL-YLGHCE 1561
I V+L A+P S P A VE+C CP GY G CQDCA GY R + L G C
Sbjct: 357 TGYIDNVTLISARP-VSGAP-APWVEQCICPVGYKGQFCQDCASGYKRDSARLGPFGTCI 414
Query: 1562 LCECNGHSDLCHPETGACSQCQHNAAGEFCELCAPGYYGDATAGTPEDCQPCACPLTNPE 1621
C C G C P+TG C N E C C G+Y D P C+PC C
Sbjct: 415 PCNCQG-GGACDPDTGDCYSGDENPDIE-CADCPIGFYND--PHDPRSCKPCPCHNGFSC 470
Query: 1622 NMFSRTCESLGAGGYRCTACEPGYTGQYCEQCGPGYVGNPSVQGGQCLP 1670
++ T E + C C PG TG CE C GY G+P + G P
Sbjct: 471 SVMPETEEVV------CNNCPPGVTGARCELCADGYFGDPFGEHGPVRP 513
Score = 159 bits (401), Expect = 8e-38
Identities = 133/441 (30%), Positives = 195/441 (44%), Gaps = 53/441 (12%)
Query: 505 CPDGHFYLE--HSAACLPCFCFGITSVCQSTRRFR-DQIRLRFDQP-DDFKGVNVTMPAQ 560
C G++ L+ + C CFC+G ++ C+S+ + +I F Q D +K V +
Sbjct: 169 CRSGYYNLDGGNPEGCTQCFCYGHSASCRSSAEYSVHKITSTFHQDVDGWKAVQ-----R 223
Query: 561 PGTPPLSSTQLQIDPSLHEFQLVDLSRRFLVHDSFWALPEQFLGNKVDSYGGSLRYNVRY 620
G+P + Q +D ++ P +FLGN+ SYG SL ++ Y
Sbjct: 224 NGSPAKLQWSQRHQDVFSSAQRLD--------PVYFVAPAKFLGNQQVSYGQSLSFD--Y 273
Query: 621 ELARGMLEPVQRPDVVLMGAGYRLLS--RGHTPTQPGALNQRQVQFSEEHWVHESGRPVQ 678
+ RG P DV+L GAG R+ + T P L + EH + +
Sbjct: 274 RVDRGGRHPSAH-DVILEGAGLRITAPLMPLGKTLPCGLTKTYTFRLNEHPSNNWSPQLS 332
Query: 679 RAELLQVLQSLEAVLIQTVYNTKMASVGLSDIAMDTTVTHA--TSHGRAHSVEECRCPIG 736
E ++L++L A+ I+ Y S G D + T+ A S A VE+C CP+G
Sbjct: 333 YFEYRRLLRNLTALRIRATYGEY--STGYID---NVTLISARPVSGAPAPWVEQCICPVG 387
Query: 737 YSGLSCESCDAHFTRVPG--GPYLGTCSGCNCNGHASSCDPVYGHCLNCQHNTEGPQCNK 794
Y G C+ C + + R GP+ GTC CNC G +CDP G C + N + +C
Sbjct: 388 YKGQFCQDCASGYKRDSARLGPF-GTCIPCNCQG-GGACDPDTGDCYSGDENPD-IECAD 444
Query: 795 CKAGFFGDAMKATATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAPGYTGRRCESC 854
C GF+ D SC+PCPC FS + +T+ + C+ C PG TG RCE C
Sbjct: 445 CPIGFYNDPHDPR--SCKPCPC-----HNGFSCSVMPETE-EVVCNNCPPGVTGARCELC 496
Query: 855 APGYEGNPIQPGGKCRPVNQEIVRCDERGSMGTSGEACR-------CKNNVVGRLCNECA 907
A GY G+P G RP + +C+ SG R C +N G C++C
Sbjct: 497 ADGYFGDPFGEHGPVRPC--QPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQCK 554
Query: 908 DGSF--HLSTRNPDGCLKCFC 926
G F L+ D C C C
Sbjct: 555 AGYFGDPLAPNPADKCRACNC 575
Score = 86.7 bits (213), Expect = 5e-16
Identities = 51/138 (36%), Positives = 64/138 (46%), Gaps = 16/138 (11%)
Query: 1522 PRALEVEECRCPPGYIGLSCQDCAPGYTRTGSGLY--LGHCELCECNGHSDL-----CHP 1574
P EV CPPG G C+ CA GY G + + C+ C+CN + D C
Sbjct: 474 PETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDR 533
Query: 1575 ETGACSQCQHNAAGEFCELCAPGYYGDATAGTPED-CQPCACPLTNPENMFSRTCESLGA 1633
TG C +C HN AG +C+ C GY+GD A P D C+ C C NP C S G
Sbjct: 534 LTGRCLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNC---NPMGSEPVGCRSDGT 590
Query: 1634 GGYRCTACEPGYTGQYCE 1651
C+PG+ G CE
Sbjct: 591 -----CVCKPGFGGPNCE 603
Score = 82.4 bits (202), Expect = 9e-15
Identities = 52/144 (36%), Positives = 68/144 (47%), Gaps = 20/144 (13%)
Query: 733 CPIGYSGLSCESCDAHFTRVPGGPY--LGTCSGCNCNGH-----ASSCDPVYGHCLNCQH 785
CP G +G CE C + P G + + C C CN + + +CD + G CL C H
Sbjct: 484 CPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIH 543
Query: 786 NTEGPQCNKCKAGFFGDAMKAT-ATSCRPCPCPYIDASRRFSDTCFLDTDGQATCDACAP 844
NT G C++CKAG+FGD + A CR C C + S+ +DG TC C P
Sbjct: 544 NTAGIYCDQCKAGYFGDPLAPNPADKCRACNC-----NPMGSEPVGCRSDG--TC-VCKP 595
Query: 845 GYTGRRCE----SCAPGYEGNPIQ 864
G+ G CE SC Y IQ
Sbjct: 596 GFGGPNCEHGAFSCPACYNQVKIQ 619
Score = 80.1 bits (196), Expect = 4e-14
Identities = 47/140 (33%), Positives = 64/140 (45%), Gaps = 22/140 (15%)
Query: 1122 EVEQCSCPPGYRGPSCQDCDTGYTRTPSGLY--LGTCERCSCHGH-----SEACEPETGA 1174
EV +CPPG G C+ C GY P G + + C+ C C+ + S C+ TG
Sbjct: 478 EVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGR 537
Query: 1175 CQGCQHHTEGPRCEQCQPGYYGDAQRGTPQD-CQLCPCY---GDPAAGQAAHTCFLDTDG 1230
C C H+T G C+QC+ GY+GD P D C+ C C +P ++ TC
Sbjct: 538 CLKCIHNTAGIYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTC------ 591
Query: 1231 HPTCDACSPGHSGRHCERCA 1250
C PG G +CE A
Sbjct: 592 -----VCKPGFGGPNCEHGA 606
Score = 35.8 bits (81), Expect = 0.96
Identities = 26/95 (27%), Positives = 37/95 (38%), Gaps = 18/95 (18%)
Query: 3847 TCRDRPCQNGGQCHDS-ESSSYVCV-CPAGFTGSRC-------------EHSQALHCHPE 3891
+C+ PC NG C E+ VC CP G TG+RC EH C P
Sbjct: 458 SCKPCPCHNGFSCSVMPETEEVVCNNCPPGVTGARCELCADGYFGDPFGEHGPVRPCQPC 517
Query: 3892 ACGPD---ATCVNRPDGRGYTCRCHLGRSGLRCEE 3923
C + + N G +C +G+ C++
Sbjct: 518 QCNNNVDPSASGNCDRLTGRCLKCIHNTAGIYCDQ 552
Score = 34.7 bits (78), Expect = 2.1
Identities = 15/43 (34%), Positives = 23/43 (53%), Gaps = 1/43 (2%)
Query: 731 CRCPIGYSGLSCESCDAHFTRVPGGPYLGTCSGCNCNGHASSC 773
C C +G C+ C + + + GG G C+ C C GH++SC
Sbjct: 155 CVCKPAVTGERCDRCRSGYYNLDGGNPEG-CTQCFCYGHSASC 196
Score = 33.9 bits (76), Expect = 3.7
Identities = 28/119 (23%), Positives = 44/119 (36%), Gaps = 21/119 (17%)
Query: 4082 VNGKRLDLTYSFLGSQGIGQCYDSSPCERQPCQHGATCMPAGEYE------FQCL----- 4130
V G R +L G+ PC+ C + +G + +C+
Sbjct: 488 VTGARCELCADGYFGDPFGEHGPVRPCQPCQCNNNVDPSASGNCDRLTGRCLKCIHNTAG 547
Query: 4131 -----CRDGFKGD-LCEHEENPCQLREPCLHGGTCQGTR----CLCLPGFSGPRCQQGS 4179
C+ G+ GD L + + C+ G G R C+C PGF GP C+ G+
Sbjct: 548 IYCDQCKAGYFGDPLAPNPADKCRACNCNPMGSEPVGCRSDGTCVCKPGFGGPNCEHGA 606
Score = 32.7 bits (73), Expect = 8.2
Identities = 24/86 (27%), Positives = 28/86 (32%), Gaps = 13/86 (15%)
Query: 3847 TCRDRPCQNGGQCHDSESSSY---------VCVCPAGFTGSRCEHSQALHCHPEACGPDA 3897
TC CQ GG C Y CP GF + C P C
Sbjct: 412 TCIPCNCQGGGACDPDTGDCYSGDENPDIECADCPIGFYN---DPHDPRSCKPCPCHNGF 468
Query: 3898 TCVNRPDGRGYTC-RCHLGRSGLRCE 3922
+C P+ C C G +G RCE
Sbjct: 469 SCSVMPETEEVVCNNCPPGVTGARCE 494
>gi|144226847 obscurin-like 1 [Homo sapiens]
Length = 1896
Score = 224 bits (570), Expect = 2e-57
Identities = 474/1977 (23%), Positives = 710/1977 (35%), Gaps = 403/1977 (20%)
Query: 1864 SAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQL--------PAKAQIHG 1915
S P P + V G AE +C G P P + W G G QL PA HG
Sbjct: 10 SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKG-GQQLAASERLSFPADGAEHG 68
Query: 1916 GILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHV---------------------HGGG 1954
L L A PTD Y+CRA ++AG+ A A + V G G
Sbjct: 69 --LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEG 126
Query: 1955 GPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL------------PPQARS 2002
P P V G V L CRA G+P T+ W K+G +L P +A
Sbjct: 127 APVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAED 186
Query: 2003 ERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASP-----------P 2051
L I A D+G Y+C A + G AQA + V ++ P
Sbjct: 187 GPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVE 246
Query: 2052 PVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPP-------HTQVHGSRLRL 2104
P+K + V EG+ C V G ++ W+ G L P + G L++
Sbjct: 247 PLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKV 306
Query: 2105 PQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA 2164
D G YVC N +G +++ + V P TRP++ H
Sbjct: 307 LYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE---------PRLRFTRPLQDVEGREH-- 355
Query: 2165 EGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQ---THGSLLRL--HQVTPADSGEYVCH 2219
L C VP + + LP R G++ RL H++ D G Y+C
Sbjct: 356 --GIAVLECKVPNSRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCE 413
Query: 2220 VVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY 2279
+ G + T+ + GPI ++ V EG+ L V +A + W
Sbjct: 414 MRGR--------VRTVANVTVKGPI--LKRLPRKLDVLEGENAVL-LVETLEAGVEGRWS 462
Query: 2280 KRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNG-MEASITVTVTGTQGANLAYPAG 2338
+ G LP +C++S+G M A + VT + + G
Sbjct: 463 RDGEELPV----------------------ICQSSSGHMHALVLPGVTREDAGEVTFSLG 500
Query: 2339 ---STQPIRIE------PSSSQVAEGQTLDLNCVV----PGQSHAQVTWHKRGGSLPVRH 2385
+T +R++ P +AE N V+ P + + + R +
Sbjct: 501 NSRTTTLLRVKCVKHSPPGPPILAEMFKGHKNTVLLTWKPPEPAPETPFIYR-----LER 555
Query: 2386 QTHGS--LLRLYQASPADSGEYVCRVLGSSVPLEASV---LVTIEPAGSVP------ALG 2434
Q GS ++ + A + E V G VP E + T+ G P +
Sbjct: 556 QEVGSEDWIQCFSIEKAGAVE----VPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAH 611
Query: 2435 VTPTVRIES--SSSQVAEGQ----TLDLNCLVAGQAHAQVTWHKRG-------------- 2474
+ PT R+ + QV +G+ +LDL+ ++ G TW G
Sbjct: 612 LVPTARLVAGLEDVQVYDGEDAVFSLDLSTIIQG------TWFLNGEELKSNEPEGQVEP 665
Query: 2475 GSLPARHQVHGSRLRLL--QVTPADSGEYVCRVVGSS--GTQEASVLVTIQQRLSGSHSQ 2530
G+L R + G + RL+ V DSG +VG S G Q+++ L TIQ+
Sbjct: 666 GALRYRIEQKGLQHRLILHAVKHQDSG----ALVGFSCPGVQDSAAL-TIQES------- 713
Query: 2531 GVAYPVRIESS----SASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV----- 2581
PV I S S + + L C + S+ TWYK G + +V
Sbjct: 714 ----PVHILSPQDRVSLTFTTSERVVLTCEL-SRVDFPATWYKDGQKVEESELLVVKMDG 768
Query: 2582 -GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPT 2640
RL +P+ DSGE+ C + VT+Q PP+ I
Sbjct: 769 RKHRLILPEAKVQDSGEFECRTEGVS----AFFGVTVQ----------DPPVHIVDPREH 814
Query: 2641 V----VEGQTLDLNCVVARQPQAIITWYKRGGSLPSRH----QTHGSHLR--LHQMSVAD 2690
V + + + L C V R+ A + WYK G + + G H R L +D
Sbjct: 815 VFVHAITSECVMLACEVDRE-DAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSD 873
Query: 2691 SGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVV 2750
GE+ C A + +I VS PS +R+ E + L C +
Sbjct: 874 GGEFQCVAGDECAYFTVTIT-DVSSWIVYPSGKVYVAAVRL----------ERVVLTCEL 922
Query: 2751 PGQAHAQVTWHKRG------GSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEA 2804
+ A+V W K G +L + RL L V DSGEY+C + S A
Sbjct: 923 -CRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEIDDES----A 977
Query: 2805 SVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVV----PGQAHAQVTW 2860
S VT+ PP+RI V + L+CVV + A V W
Sbjct: 978 SFTVTVT--------------EPPVRIIYPRDEVTL-IAVTLECVVLMCELSREDAPVRW 1022
Query: 2861 HKRGGNLPARHQV----HGPLLR--LNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSS 2914
+K G + + GP R L P D GE+ C S +V
Sbjct: 1023 YKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTA------ 1076
Query: 2915 PGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTH-G 2973
P + P + H ++L C V A +QV WYK G + A G
Sbjct: 1077 ----PPERIVHPA-ARSLDLHFGAPGRVELRCEV-APAGSQVRWYKDGLEVEASDALQLG 1130
Query: 2974 SQ-----LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV--PPSEGSSYRLRSPVISI 3026
++ L L P D+GEYVC + +F V + PP ++ +
Sbjct: 1131 AEGPTRTLTLPHAQPEDAGEYVCETR-----HEAITFNVILAEPP-------VQFLALET 1178
Query: 3027 DPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELED----NVHISPNGSIITIVGTR 3082
P V G+ C + AP+ W + +++ +H ++ I
Sbjct: 1179 TPSPLCVAPGEPVVLSCELSRAGAPV--VWSHNGRPVQEGEGLELHAEGPRRVLCIQAAG 1236
Query: 3083 PSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE-GPVWVKVGKAVTLE-CVSAGEP 3140
P++ G Y C + A G + V PP V PE V+ LE V P
Sbjct: 1237 PAHAGLYTCQSGAAPGAPSLSFTVQVAEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGP 1296
Query: 3141 RSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEV 3200
RW + A + + VL++ A+ DAG Y+C A Q
Sbjct: 1297 GGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDA--------PQDSR 1348
Query: 3201 IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK---LRSPLPWQHR 3257
I P ++ +E LTV G AT RC + P + W + + +P P
Sbjct: 1349 IFLVSVEEPLLVKLVSELTPLTVHEGDDATFRCEVS-PPDADVTWLRNGAVVTPGPQVEM 1407
Query: 3258 LE-GDTLIIPRVAQQ--DSGQYICNATSPAGHAEATIILHV-ESPPYATTVPEHASVQAG 3313
+ G + I+ Q D+G T AG + LHV E+ + + G
Sbjct: 1408 AQNGSSRILTLRGCQLGDAG----TVTLRAGSTATSARLHVRETELLFLRRLQDVRAEEG 1463
Query: 3314 ETVQLQCLAHGTPPL----TFQWSRVGSSLP---GRATARNELLH---FERAAPEDSGRY 3363
+ V CL T + +W R G LP + A++ +H D G Y
Sbjct: 1464 QDV---CLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTY 1520
Query: 3364 RCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLE--TKSIGASVEFHC 3421
C + A+L V+ P L +V LE T S G S F
Sbjct: 1521 GCESHHD----RTLARLSVR--PRQL-------------RVLRPLEDVTISEGGSATFQL 1561
Query: 3422 AVPSDRGTQLRWFKEGGQLPPG---HSVQDG---VLRIQNLDQSCQGTYICQAHGPWGKA 3475
+ S G W + G QL PG H DG L + L + G A
Sbjct: 1562 EL-SQEGVTGEWARGGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTA----DSL 1616
Query: 3476 QASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG--- 3532
+ +A+L+++ +P ++ ++ V G FEC L VTW K G L P
Sbjct: 1617 RCAARLIVREVPVTIVRGPHDLE-VTEGDTATFEC-ELSQALADVTWEKDGNALTPSPRL 1674
Query: 3533 IVQSGGVVRIAHVEL---ADAGQYRCTATNAAGTTQSHVLLLV---QALPQISMPQEVRV 3586
+Q+ G R+ + +DAG Y C A GT ++ + L + + +S + V
Sbjct: 1675 RLQALGTRRLLQLRRCGPSDAGTYSC----AVGTARAGPVRLTVRERTVAVLSELRSVSA 1730
Query: 3587 PAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL------ENNMLMLPSVRPQDAG 3637
G A F C S T W L P +R+ + ++L+L +R +DAG
Sbjct: 1731 REGDGATFECTVSEVETTG-RWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAG 1786
Score = 213 bits (542), Expect = 3e-54
Identities = 502/2067 (24%), Positives = 749/2067 (36%), Gaps = 405/2067 (19%)
Query: 1779 RSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDF------NGILTIRNVQL 1832
R V GA+ C + P +VW + + + F +G+L +
Sbjct: 19 RPVRVVSGAEAELKCVVLGEPPP-VVVWEKGGQQLAASERLSFPADGAEHGLLLTAALP- 76
Query: 1833 SDAGTYVCTGSNMFAMDQGTATLHV-------------------QASGTLSAPVVSIHPP 1873
+DAG YVC N A + V SG APV P
Sbjct: 77 TDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGE-GAPVFLTGPR 135
Query: 1874 QLTVQPGQLAEFRCSATGSPTPTLEWT-----------GGPGGQLPAKAQIHGGI---LR 1919
V G C A G P PTL W P +A+ G LR
Sbjct: 136 SQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLALR 195
Query: 1920 LPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHG-----------GGGPRVQ---VSPERT 1965
+ A D Y+C A ++ G A A+L VH P V+ +P+
Sbjct: 196 ILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKTF 255
Query: 1966 QVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARS----ERTDIATLLIPAITTADAG 2021
V+ G+ + C G P I W EG L P R +R L + D G
Sbjct: 256 WVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRG 315
Query: 2022 FYLCVATSPAGTAQARIQVVVLSASDASPPPVK-IESSSPSVTEGQTLDLNCVVAGSAHA 2080
Y+C A + AG + +Q+ V P++ +E + L C V S
Sbjct: 316 LYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAV-----LECKVPNS-RI 369
Query: 2081 QVTWYRRGGSLPP---HTQVHGS---RLRLPQVSPADSGEYVCRVENGSGPKEASITVSV 2134
W+R L P + Q+ RL + ++ D G Y+C + G A++TV
Sbjct: 370 PTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMR-GRVRTVANVTVK- 427
Query: 2135 LHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA 2194
GP +P R + + + V +TL+ A + W + G LP
Sbjct: 428 ------GPILKRLP---RKLDVLEGENAVLLVETLE--------AGVEGRWSRDGEELPV 470
Query: 2195 RHQT---HGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIES 2251
Q+ H L L VT D+GE V + G + L+ ++ P PP+ E
Sbjct: 471 ICQSSSGHMHALVLPGVTREDAGE----VTFSLGNSRTTTLLRVKCVKHSPPGPPILAEM 526
Query: 2252 SSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYV- 2310
T+ L+ A Y+ Q GS +I S AG
Sbjct: 527 FKG---HKNTVLLTWKPPEPAPETPFIYR------LERQEVGSEDWIQCFSIEKAGAVEV 577
Query: 2311 ---CRASNGMEASITVTVTGTQGANLAYPAGS-----TQPIRIEPSSSQVAEGQ----TL 2358
C S G TV+G + GS T + QV +G+ +L
Sbjct: 578 PGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDGEDAVFSL 637
Query: 2359 DLNCVVPGQSHAQVTWHKRG--------------GSLPVRHQTHGSLLRL--YQASPADS 2402
DL+ ++ G TW G G+L R + G RL + DS
Sbjct: 638 DLSTIIQG------TWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDS 691
Query: 2403 GEYVCRVLGSSVP-LEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVA 2461
G V G S P ++ S +TI+ + P ++P R+ S + + L C ++
Sbjct: 692 GALV----GFSCPGVQDSAALTIQES---PVHILSPQDRV---SLTFTTSERVVLTCELS 741
Query: 2462 GQAHAQVTWHKRGGSLPARH----QVHGSRLRLL--QVTPADSGEYVCRVVGSSGTQEAS 2515
+ TW+K G + ++ G + RL+ + DSGE+ CR G S A
Sbjct: 742 -RVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVS----AF 796
Query: 2516 VLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVAS------QAPHTITWYK 2569
VT+Q PV I + H + C++ + AP + WYK
Sbjct: 797 FGVTVQDP-----------PVHIVDPREHVFV-HAITSECVMLACEVDREDAP--VRWYK 842
Query: 2570 RGGSLPSRHQIV------GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 2623
G + +V RL +P P+D GE+ C AG VTI SS
Sbjct: 843 DGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCV----AGDECAYFTVTITDV-SS 897
Query: 2624 HVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGG------SLPSRHQTH 2677
+ S + + + V + + L C + R P A + W K G +L + +
Sbjct: 898 WIVYPSGKVYVAA-----VRLERVVLTCELCR-PWAEVRWTKDGEEVVESPALLLQKEDT 951
Query: 2678 GSHLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH 2737
L L + + DSGEY+C ID AS ++V+ P+RI
Sbjct: 952 VRRLVLPAVQLEDSGEYLCE----IDDESASFTVTVTEP-----------PVRIIYPRDE 996
Query: 2738 VAEGETLDLNCVVP----GQAHAQVTWHKRG------GSLPSHHQTRGSRLRLHHVSPAD 2787
V + L CVV + A V W+K G +L RL L P D
Sbjct: 997 VTL-IAVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPED 1055
Query: 2788 SGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPG-----GAPPIRIEPSSSRVAEGQ 2842
GE+VC +G A VT+ A VH A GAP
Sbjct: 1056 GGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHFGAPG-------------- 1097
Query: 2843 TLDLKCVVPGQAHAQVTWHKRGGNLPARHQVH----GPL--LRLNQVSPADSGEYSCQVT 2896
++L+C V A +QV W+K G + A + GP L L P D+GEY C+
Sbjct: 1098 RVELRCEV-APAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCETR 1156
Query: 2897 GSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQV 2956
+ T ++ EP P LA + S V G+ + L+C + +A A V
Sbjct: 1157 HEAITFN---VILAEP------PVQFLA--LETTPSPLCVAPGEPVVLSCEL-SRAGAPV 1204
Query: 2957 TWYKRGGSLPARHQTHGSQLRLHL-----------VSPADSGEYVCRAASGPGPEQEASF 3005
W G R G L LH PA +G Y C++ + PG SF
Sbjct: 1205 VWSHNG-----RPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPS-LSF 1258
Query: 3006 TVTV--PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL 3063
TV V PP V++ + + V+ + ++H + W + L
Sbjct: 1259 TVQVAEPPVR---------VVAPEAAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERL 1309
Query: 3064 --EDNVHISPNGS--IITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE 3119
+ V + G+ ++ + G R + G Y C A + +SV P V ++ E
Sbjct: 1310 ASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQD----SRIFLVSVEEPLLVKLVSE 1365
Query: 3120 -GPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPS 3178
P+ V G T C P + W R + Q S +L + +
Sbjct: 1366 LTPLTVHEGDDATFRC-EVSPPDADVTWLRNGAVVTPGPQVEMAQNGSSRILTLRGCQLG 1424
Query: 3179 DAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQ-VQAEEAE---LTVEAGHTATLRCS 3234
DAGT A + +A+ V +T + Q V+AEE + L VE G R
Sbjct: 1425 DAGTVTLRAGSTATSARLHVR---ETELLFLRRLQDVRAEEGQDVCLEVETG-----RVG 1476
Query: 3235 ATGSPAPTIHWSKLRSPLPWQHRLEG------DTLIIPRVAQQDSGQYICNATSPAGHAE 3288
A G+ + W + PLP RL L I V D G Y C + A
Sbjct: 1477 AAGA----VRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLAR 1532
Query: 3289 ATII---LHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSL-PG--- 3341
++ L V P T+ E S T QL+ G +T +W+R G L PG
Sbjct: 1533 LSVRPRQLRVLRPLEDVTISEGGSA----TFQLELSQEG---VTGEWARGGVQLYPGPKC 1585
Query: 3342 --RATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGST 3399
+ L DSG C V+ S A+L+V+ P ++
Sbjct: 1586 HIHSDGHRHRLVLNGLGLADSG---C-VSFTADSLRCAARLIVREVPVTI---------- 1631
Query: 3400 PTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ------DGVLRI 3453
V+ LE G + F C + S + W K+G L P ++ +L++
Sbjct: 1632 --VRGPHDLEVTE-GDTATFECEL-SQALADVTWEKDGNALTPSPRLRLQALGTRRLLQL 1687
Query: 3454 QNLDQSCQGTYICQAHGPWGKAQAS-AQLVIQALPSVLINIRTSVQTVVVGHAVEFECLA 3512
+ S GTY C G A+A +L ++ +++ SV + G FEC
Sbjct: 1688 RRCGPSDAGTYSCAV----GTARAGPVRLTVRERTVAVLSELRSV-SAREGDGATFEC-T 1741
Query: 3513 LGDPKPQVTWSKVGGHLRPG----IVQSGG--VVRIAHVELADAGQYRCTATNAAGTTQS 3566
+ + + W G LRPG I Q G ++ ++ + DAG+ R A G QS
Sbjct: 1742 VSEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA----GPAQS 1797
Query: 3567 HVLLLVQALPQISM----PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE 3622
LL V+ALP + M P+E V G AV S + W + L P + E
Sbjct: 1798 LALLEVEALP-LQMCRHPPREKTVLVGRRAVLEVTVSR-SGGHVCWLREGAELCPGDKYE 1855
Query: 3623 ------NNMLMLPSVRPQDAGTYVCTA 3643
+ L++ VRP+D GTY C A
Sbjct: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
Score = 187 bits (476), Expect = 2e-46
Identities = 450/1967 (22%), Positives = 693/1967 (35%), Gaps = 373/1967 (18%)
Query: 1670 PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGS 1729
P + + V P V +G L C+ G P YW + DG + H
Sbjct: 121 PGSGEGAPVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEK-DGMALDEVWDSSHFAL 179
Query: 1730 E-------------LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVE 1776
+ L + + D+GVY+C RN H + A L V + P P +
Sbjct: 180 QPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESP-PADPD 238
Query: 1777 EQRSQSVRP------------GADVTFICTAKSKSPAYTLVWTRLHNGKLPTRA------ 1818
E + V P G F C K P + W LP R
Sbjct: 239 EAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGK-PEPEIEWHWEGRPLLPDRRRLMYRD 297
Query: 1819 MDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQ 1878
D +L + Q D G YVC N LHV+ P + P V+
Sbjct: 298 RDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVK------EPRLRFTRPLQDVE 351
Query: 1879 PGQ--LAEFRCSATGSPTPTLEWTGGPGGQLPAK--AQIHGGILR---LPAVEPTDQAQY 1931
+ +A C S PT W LP + QI G +R + ++ D Y
Sbjct: 352 GREHGIAVLECKVPNSRIPT-AWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIY 410
Query: 1932 LCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRA--AGVPSATITW 1989
LC + VA + GP ++ P + V G L AGV W
Sbjct: 411 LCEMRGRV-RTVANVTVK-----GPILKRLPRKLDVLEGENAVLLVETLEAGVEG---RW 461
Query: 1990 RKEGGSLPPQARSERTDIATLLIPAITTADAG---FYL------------CVATSPAGTA 2034
++G LP +S + L++P +T DAG F L CV SP G
Sbjct: 462 SRDGEELPVICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPGPP 521
Query: 2035 ------QARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRG 2088
+ V+L+ P P +P + + + V Q +
Sbjct: 522 ILAEMFKGHKNTVLLTWKPPEPAP-----ETPFIYRLERQE----VGSEDWIQCFSIEKA 572
Query: 2089 GSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGT-HSGPSYTPV 2147
G+ + +P G+Y R+ SG + V HG+ H P+ V
Sbjct: 573 GA-----------VEVPGDCVPSEGDYRFRICTVSGHGRSPHV--VFHGSAHLVPTARLV 619
Query: 2148 PGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRG--------------GSLP 2193
G +++ V +LDL+ ++ G TW G G+L
Sbjct: 620 AG-LEDVQVYDGEDAVF---SLDLSTIIQG------TWFLNGEELKSNEPEGQVEPGALR 669
Query: 2194 ARHQTHG--SLLRLHQVTPADSGEYVCHVVGTSGP-LEASVLVTIEASVIPGPIPPVRIE 2250
R + G L LH V DSG +VG S P ++ S +TI+ S + P R+
Sbjct: 670 YRIEQKGLQHRLILHAVKHQDSGA----LVGFSCPGVQDSAALTIQESPVHILSPQDRV- 724
Query: 2251 SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGS------LPARHQVRGSRLYIFQASPA 2304
S T + + L+C ++ + TWYK G L + R RL + +A
Sbjct: 725 --SLTFTTSERVVLTCELS-RVDFPATWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQ 781
Query: 2305 DAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQV----AEGQTLDL 2360
D+G++ CR + G+ A VTV P+ I V + + L
Sbjct: 782 DSGEFECR-TEGVSAFFGVTV-------------QDPPVHIVDPREHVFVHAITSECVML 827
Query: 2361 NCVVPGQSHAQVTWHKRGGSLP------VRHQTHGSLLRLYQASPADSGEYVCRVLGSSV 2414
C V + A V W+K G + + ++ L L P+D GE+ C V G
Sbjct: 828 ACEV-DREDAPVRWYKDGQEVEESDFVVLENEGPHRRLVLPATQPSDGGEFQC-VAGDEC 885
Query: 2415 PLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG 2474
A VTI V + V P+ ++ ++ ++ + + L C + + A+V W K G
Sbjct: 886 ---AYFTVTIT---DVSSWIVYPSGKVYVAAVRL---ERVVLTCELC-RPWAEVRWTKDG 935
Query: 2475 ------GSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSH 2528
+L + + RL L V DSGEY+C + + AS VT+ +
Sbjct: 936 EEVVESPALLLQKEDTVRRLVLPAVQLEDSGEYLCEI----DDESASFTVTVTEP----- 986
Query: 2529 SQGVAYPVRI--ESSSASLANGHTLDLNCLV----ASQAPHTITWYKRGGSLPSRHQIV- 2581
PVRI +L + L C+V S+ + WYK G + +V
Sbjct: 987 ------PVRIIYPRDEVTLI---AVTLECVVLMCELSREDAPVRWYKDGLEVEESEALVL 1037
Query: 2582 -----GSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIES 2636
RL +P P D GE+VC AG VT+ V + + +
Sbjct: 1038 ERDGPRCRLVLPAAQPEDGGEFVC----DAGDDSAFFTVTVTAPPERIVHPAARSLDLHF 1093
Query: 2637 SSPTVVEGQTLDLNCVVARQPQAIITWYKRG------GSLPSRHQTHGSHLRLHQMSVAD 2690
+P VE L C VA + + WYK G +L + L L D
Sbjct: 1094 GAPGRVE-----LRCEVA-PAGSQVRWYKDGLEVEASDALQLGAEGPTRTLTLPHAQPED 1147
Query: 2691 SGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVV 2750
+GEYVC + +A+ +++++ P + + S VA GE + L+C +
Sbjct: 1148 AGEYVCETRH--EAITFNVILA--------EPPVQFLALETTPSPLCVAPGEPVVLSCEL 1197
Query: 2751 PGQAHAQVTWH------KRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEA 2804
+A A V W + G L H + L + PA +G Y C+ + G
Sbjct: 1198 -SRAGAPVVWSHNGRPVQEGEGLELHAEGPRRVLCIQAAGPAHAGLYTCQSGAAPGAPSL 1256
Query: 2805 SVLVTIEASGSSAVHVPAPGGAPPIRI---EPSSSRVAEGQTLDLKCVV----PGQAHAQ 2857
S V + PP+R+ E + +RV DL+ VV PG
Sbjct: 1257 SFTVQV--------------AEPPVRVVAPEAAQTRVRSTPGGDLELVVHLSGPG---GP 1299
Query: 2858 VTWHKRGGNLPARHQVH------GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE 2911
V W+K G L ++ +V +LR+ D+GEY C S LV++E
Sbjct: 1300 VRWYKDGERLASQGRVQLEQAGARQVLRVQGARSGDAGEYLCDAPQDSRIF----LVSVE 1355
Query: 2912 PSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQT 2971
L + E + V EG C V A VTW + G + Q
Sbjct: 1356 EP---------LLVKLVSELTPLTVHEGDDATFRCEV-SPPDADVTWLRNGAVVTPGPQV 1405
Query: 2972 HGSQ------LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVIS 3025
+Q L L D+G RA S S + V +E R V
Sbjct: 1406 EMAQNGSSRILTLRGCQLGDAGTVTLRAGS-----TATSARLHVRETELLFLRRLQDV-- 1458
Query: 3026 IDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQEL--EDNVHISPNGSI--ITIVGT 3081
++GQD + A ++ W Q L + + ++ +G I + I G
Sbjct: 1459 ------RAEEGQDVCLEVETGRVGAAGAVRWVRGGQPLPHDSRLSMAQDGHIHRLFIHGV 1512
Query: 3082 RPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPR 3141
++ GTY C + + +++ LSV + P V + G + T + + +
Sbjct: 1513 ILADQGTYGCESHH----DRTLARLSVRPRQLRVLRPLEDVTISEGGSATFQ-LELSQEG 1567
Query: 3142 SSARWTRISSTPAKLEQRTYGLMDSHA-VLQISSAKPSDAGTYVCLAQNALGTAQKQVEV 3200
+ W R + + D H L ++ +D+G A + A+ V
Sbjct: 1568 VTGEWAR-GGVQLYPGPKCHIHSDGHRHRLVLNGLGLADSGCVSFTADSLRCAARLIVRE 1626
Query: 3201 IVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG 3260
+ T P +L V G TAT C + + A + W K + L RL
Sbjct: 1627 VPVTIVRGP---------HDLEVTEGDTATFECELSQALA-DVTWEKDGNALTPSPRLRL 1676
Query: 3261 DTLIIPRVAQ------QDSGQYICN-ATSPAGHAEATIILHVESPPYATTVPEHASVQAG 3313
L R+ Q D+G Y C T+ AG T+ E + S + G
Sbjct: 1677 QALGTRRLLQLRRCGPSDAGTYSCAVGTARAGPVRLTV---RERTVAVLSELRSVSAREG 1733
Query: 3314 ETVQLQCLAHGTPPLTFQWSRVGSSL-PG-----RATARNELLHFERAAPEDSGRYRCRV 3367
+ +C T +W G L PG R + +L ED+G R +
Sbjct: 1734 DGATFECTV-SEVETTGRWELGGRPLRPGARVRIRQEGKKHILVLSELRAEDAGEVRFQA 1792
Query: 3368 TNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDR 3427
GP SL + A + P+ +T +G V S
Sbjct: 1793 ----------------GPAQSLALLEVEALPLQMCRHPPREKTVLVGRRAVLEVTV-SRS 1835
Query: 3428 GTQLRWFKEGGQLPPGHSVQ------DGVLRIQNLDQSCQGTYICQA 3468
G + W +EG +L PG + L I ++ QGTY CQA
Sbjct: 1836 GGHVCWLREGAELCPGDKYEMRSHGPTHSLVIHDVRPEDQGTYCCQA 1882
Score = 122 bits (305), Expect = 1e-26
Identities = 270/1150 (23%), Positives = 406/1150 (35%), Gaps = 192/1150 (16%)
Query: 2629 SPPIRIESSSPT-VVEGQTLDLNCVVARQPQAIITWYKRGGSL--------PSRHQTHGS 2679
SPP + P VV G +L CVV +P ++ W K G L P+ HG
Sbjct: 10 SPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG- 68
Query: 2680 HLRLHQMSVADSGEYVCRANNNI-DALEASIVISVSPSAGSPSAPGSSMPIRIESS---- 2734
L L D+G YVCRA N +A A+ V + P A P + P+ S
Sbjct: 69 -LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGA 127
Query: 2735 --------SSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLP-----SHHQTRGSR---- 2777
S V G + L C G + W K G +L SH + R
Sbjct: 128 PVFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDG 187
Query: 2778 ------LRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAP---P 2828
LR+ DSG YVC + G +A L+ + S P AP P
Sbjct: 188 PGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEP 247
Query: 2829 IRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNL-PARHQVH------GPLLRLN 2881
++ P + V EG+ +C V G+ ++ WH G L P R ++ G +L++
Sbjct: 248 LKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
Query: 2882 QVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQT 2941
D G Y C S+G ++V + ++ P +P+ H
Sbjct: 308 YCQAKDRGLYVCAARNSAGQTLSAVQLHVKE------PRLRFTRPLQDVEGREH----GI 357
Query: 2942 LDLNCVVPGQAHAQVTWYKRGGSL-PARHQTHGSQ-----LRLHLVSPADSGEYVCRAAS 2995
L C VP + W++ L P R + L +H + D G Y+C
Sbjct: 358 AVLECKVPN-SRIPTAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRG 416
Query: 2996 GPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLE 3055
VTV + P++ P V +G++A L+ A +
Sbjct: 417 ----RVRTVANVTV----------KGPILKRLPRKLDVLEGENAVL--LVETLEAGVEGR 460
Query: 3056 WKTRNQELEDNVHISPNGSIITIV--GTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPT 3113
W +EL + S +G + +V G + G N+ V H PP
Sbjct: 461 WSRDGEELPV-ICQSSSGHMHALVLPGVTREDAGEVTFSLGNSRTTTLLRVKCVKHSPPG 519
Query: 3114 VSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQIS 3173
+L E K K L EP + +LE++ G D I
Sbjct: 520 PPILAE---MFKGHKNTVLLTWKPPEPAPETPFIY------RLERQEVGSEDWIQCFSIE 570
Query: 3174 SAK----PSDA----GTYVCLAQNALGTAQKQVEV------IVDTGAMAPGAPQVQAEEA 3219
A P D G Y G + V +V T + G VQ +
Sbjct: 571 KAGAVEVPGDCVPSEGDYRFRICTVSGHGRSPHVVFHGSAHLVPTARLVAGLEDVQVYDG 630
Query: 3220 ELTVEAGHTATLRCSA---------TGSPAPTIHWSKLRSPLPW---QHRLEGDTLIIPR 3267
E V + +T+ + P + LR + QHRL I+
Sbjct: 631 EDAVFSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRL-----ILHA 685
Query: 3268 VAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQ--AGETVQLQC-LAHG 3324
V QDSG + S G ++ + ESP + + + S+ E V L C L+
Sbjct: 686 VKHQDSGALV--GFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTCELSRV 743
Query: 3325 TPPLTFQWSRVGSS------LPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFA 3378
P T W + G L + R L A +DSG + CR AF
Sbjct: 744 DFPAT--WYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG----VSAFF 797
Query: 3379 QLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGG 3438
+ VQ PP + P V T V C V + +RW+K+G
Sbjct: 798 GVTVQDPPVHIV--------DPREHVFVHAITSEC---VMLACEVDRE-DAPVRWYKDGQ 845
Query: 3439 QLPPGHSV---QDGVLR---IQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLIN 3492
++ V +G R + S G + C A G A + I + S ++
Sbjct: 846 EVEESDFVVLENEGPHRRLVLPATQPSDGGEFQCVA----GDECAYFTVTITDVSSWIVY 901
Query: 3493 IRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG---IVQSGGVVR---IAHVE 3546
V V L P +V W+K G + ++Q VR + V+
Sbjct: 902 PSGKVYVAAVRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPAVQ 961
Query: 3547 LADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ-EVRVPAGS--AAVFPCIASGYPT 3603
L D+G+Y C + + S + + + +I P+ EV + A + V C S
Sbjct: 962 LEDSGEYLCEIDDESA---SFTVTVTEPPVRIIYPRDEVTLIAVTLECVVLMCELSREDA 1018
Query: 3604 PDISWSKLDGSLPPDSR---LENN----MLMLPSVRPQDAGTYVCTATNRQGKVKAFAHL 3656
P + W K DG +S LE + L+LP+ +P+D G +VC A G AF +
Sbjct: 1019 P-VRWYK-DGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDA----GDDSAFFTV 1072
Query: 3657 QV---PERVV 3663
V PER+V
Sbjct: 1073 TVTAPPERIV 1082
Score = 117 bits (293), Expect = 3e-25
Identities = 138/501 (27%), Positives = 190/501 (37%), Gaps = 89/501 (17%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPS-----------V 1736
V G L+C V G PP W + G QQ L FP+
Sbjct: 23 VVSGAEAELKCVVLGEPPPVVVWEK--------GGQQLAASERLSFPADGAEHGLLLTAA 74
Query: 1737 QPSDAGVYICTCRNLHQSNTSRAELLVTEAPS---------KPI---------TVTVEEQ 1778
P+DAGVY+C RN + A + V E P+ +P+ V +
Sbjct: 75 LPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAPVFLTGP 134
Query: 1779 RSQSVRPGADVTFICTA----------KSKSPAYTLVWTRLHNGKLPTRAMDFNG---IL 1825
RSQ V GA+V C A + A VW H P RA D G L
Sbjct: 135 RSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGPGASLAL 194
Query: 1826 TIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQA--------SGTLSAPVV---SIHPPQ 1874
I +L D+G YVC N Q A L V APVV P
Sbjct: 195 RILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPLKCAPKT 254
Query: 1875 LTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQI------HGGILRLPAVEPTDQ 1928
V G+ A+FRC G P P +EW LP + ++ G +L++ + D+
Sbjct: 255 FWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDR 314
Query: 1929 AQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI- 1987
Y+C A +SAGQ ++ LHV PR++ + V GR + VP++ I
Sbjct: 315 GLYVCAARNSAGQTLSAVQLHVK---EPRLRFTRPLQDVE-GREHGIAVLECKVPNSRIP 370
Query: 1988 -TWRKEGGSLPPQARSERTDIAT---LLIPAITTADAGFYLCVATSPAGTAQARIQVVVL 2043
W +E L P + E+ + T L+I + D G YLC + R +V +
Sbjct: 371 TAWFREDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLC---------EMRGRVRTV 421
Query: 2044 SASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQV---HGS 2100
+ P +K V EG+ L V A + W R G LP Q H
Sbjct: 422 ANVTVKGPILKRLPRKLDVLEGENAVL-LVETLEAGVEGRWSRDGEELPVICQSSSGHMH 480
Query: 2101 RLRLPQVSPADSGEYVCRVEN 2121
L LP V+ D+GE + N
Sbjct: 481 ALVLPGVTREDAGEVTFSLGN 501
Score = 117 bits (293), Expect = 3e-25
Identities = 318/1298 (24%), Positives = 468/1298 (36%), Gaps = 241/1298 (18%)
Query: 2083 TWYRRGGSLPPHTQV------HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLH 2136
TWY+ G + + RL LP+ DSGE+ CR E VS
Sbjct: 748 TWYKDGQKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEG----------VSAFF 797
Query: 2137 GTHSGPSYTPVPGSTRPIRIEPSSSHV----AEGQTLDLNCVVPGQAHAQVTWHKRGGSL 2192
G V P+ I HV + + L C V + A V W+K G +
Sbjct: 798 G---------VTVQDPPVHIVDPREHVFVHAITSECVMLACEVDRE-DAPVRWYKDGQEV 847
Query: 2193 PA------RHQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPP 2246
++ L L P+D GE+ C V +V +T +S I P
Sbjct: 848 EESDFVVLENEGPHRRLVLPATQPSDGGEFQC--VAGDECAYFTVTITDVSSWIVYPSGK 905
Query: 2247 VRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSL---PA---RHQVRGSRLYIFQ 2300
V + + + + L+C + + A+V W K G + PA + + RL +
Sbjct: 906 VYVAA-----VRLERVVLTCELC-RPWAEVRWTKDGEEVVESPALLLQKEDTVRRLVLPA 959
Query: 2301 ASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDL 2360
D+G+Y+C + AS TVTVT + YP I + L
Sbjct: 960 VQLEDSGEYLCEIDDE-SASFTVTVTEPP-VRIIYPRDEVTLIAVT-------------L 1004
Query: 2361 NCVVP----GQSHAQVTWHKRG------GSLPVRHQTHGSLLRLYQASPADSGEYVCRVL 2410
CVV + A V W+K G +L + L L A P D GE+VC
Sbjct: 1005 ECVVLMCELSREDAPVRWYKDGLEVEESEALVLERDGPRCRLVLPAAQPEDGGEFVCDAG 1064
Query: 2411 GSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTW 2470
S A VT+ + P V P R S ++L C VA A +QV W
Sbjct: 1065 DDS----AFFTVTVT---APPERIVHPAAR--SLDLHFGAPGRVELRCEVA-PAGSQVRW 1114
Query: 2471 HKRGGSLPARHQVH------GSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRL 2524
+K G + A + L L P D+GEYVC EA +T L
Sbjct: 1115 YKDGLEVEASDALQLGAEGPTRTLTLPHAQPEDAGEYVCET-----RHEA---ITFNVIL 1166
Query: 2525 SGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV--- 2581
+ Q +A + S +A G + L+C + S+A + W G + +
Sbjct: 1167 AEPPVQFLA--LETTPSPLCVAPGEPVVLSCEL-SRAGAPVVWSHNGRPVQEGEGLELHA 1223
Query: 2582 -GSR--LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRI---E 2635
G R L I PA +G Y C +GA SL T+Q + PP+R+ E
Sbjct: 1224 EGPRRVLCIQAAGPAHAGLYTCQ--SGAAPGAPSLSFTVQVA--------EPPVRVVAPE 1273
Query: 2636 SSSPTVVEGQTLDLNCVVARQ-PQAIITWYKRGGSLPSRHQTHGSH------LRLHQMSV 2688
++ V DL VV P + WYK G L S+ + LR+
Sbjct: 1274 AAQTRVRSTPGGDLELVVHLSGPGGPVRWYKDGERLASQGRVQLEQAGARQVLRVQGARS 1333
Query: 2689 ADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2748
D+GEY+C DA + S + VS + + E + V EG+ C
Sbjct: 1334 GDAGEYLC------DAPQDSRIFLVSVEEPL------LVKLVSELTPLTVHEGDDATFRC 1381
Query: 2749 VVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG-PLEASVL 2807
V A VTW + G + Q V A +G R++ G L +
Sbjct: 1382 EV-SPPDADVTWLRNGAVVTPGPQ----------VEMAQNGS--SRILTLRGCQLGDAGT 1428
Query: 2808 VTIEASG---SSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRG 2864
VT+ A S+ +HV R++ + + L+++ G A A V W + G
Sbjct: 1429 VTLRAGSTATSARLHVRETELLFLRRLQDVRAEEGQDVCLEVETGRVGAAGA-VRWVRGG 1487
Query: 2865 GNLPARHQV------HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASV----LVTIEPSS 2914
LP ++ H L ++ V AD G Y C+ SV L + P
Sbjct: 1488 QPLPHDSRLSMAQDGHIHRLFIHGVILADQGTYGCESHHDRTLARLSVRPRQLRVLRPLE 1547
Query: 2915 PGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQ-AHAQVTWYKRGGSLPARHQTHG 2973
I G A +E S VT G+ A V Y G H
Sbjct: 1548 DVTISEGGSAT-FQLELSQEGVT------------GEWARGGVQLYP-GPKCHIHSDGHR 1593
Query: 2974 SQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTV 3033
+L L+ + ADSG C + + A V P I P V
Sbjct: 1594 HRLVLNGLGLADSG---CVSFTADSLRCAARLIVREVPV----------TIVRGPHDLEV 1640
Query: 3034 QQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSI-ITIVGTR---------P 3083
+G A+F+C + A ++ E +D ++P+ + + +GTR P
Sbjct: 1641 TEGDTATFECELSQALADVTWE--------KDGNALTPSPRLRLQALGTRRLLQLRRCGP 1692
Query: 3084 SNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE-GPVWVKVGKAVTLECVSAGEPRS 3142
S+ GTY C A V L+V TV+VL E V + G T EC + E +
Sbjct: 1693 SDAGTYSCAVGTARA---GPVRLTVR-ERTVAVLSELRSVSAREGDGATFEC-TVSEVET 1747
Query: 3143 SARWT---RISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVE 3199
+ RW R A++ R G +L +S + DAG A A A +VE
Sbjct: 1748 TGRWELGGRPLRPGARVRIRQEG---KKHILVLSELRAEDAGEVRFQAGPAQSLALLEVE 1804
Query: 3200 VIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL----PWQ 3255
+ P E TV G A L + + S + W + + L ++
Sbjct: 1805 ALPLQMCRHP--------PREKTVLVGRRAVLEVTVSRSGGH-VCWLREGAELCPGDKYE 1855
Query: 3256 HRLEGDT--LIIPRVAQQDSGQYICNATSPAGHAEATI 3291
R G T L+I V +D G Y C A + H +
Sbjct: 1856 MRSHGPTHSLVIHDVRPEDQGTYCCQAGQDSTHTRLLV 1893
Score = 117 bits (292), Expect = 3e-25
Identities = 214/914 (23%), Positives = 329/914 (35%), Gaps = 136/914 (14%)
Query: 2825 GAPPIRIE-PSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPL------ 2877
G+PP + P RV G +LKCVV G+ V W K G L A ++ P
Sbjct: 9 GSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHG 68
Query: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTI-EP--SSP------GPIPAPGLAQ--P 2926
L L P D+G Y C+ ++G A+ VT+ EP S P P+P+PG + P
Sbjct: 69 LLLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLPSPGSGEGAP 128
Query: 2927 IYIEASSSH-VTEGQTLDLNCVVPGQAHAQVTWYKRGGSL------------PARHQT-H 2972
+++ S V G + L C G + W K G +L P R +
Sbjct: 129 VFLTGPRSQWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHFALQPGRAEDGP 188
Query: 2973 GSQLRLHLVSP--ADSGEYVCRAASGPGPEQE-ASFTVTVPPSEGSSYRLRSPVISID-- 3027
G+ L L +++ DSG YVC A + G Q A V PP + +P ++
Sbjct: 189 GASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADPDEAPAPVVEPL 248
Query: 3028 ---PPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN-----VHISPNGSIITIV 3079
P + V +G+ A F+C + P +EW + L + G ++ ++
Sbjct: 249 KCAPKTFWVNEGKHAKFRCYVMGKPEP-EIEWHWEGRPLLPDRRRLMYRDRDGGFVLKVL 307
Query: 3080 GTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGE 3139
+ + G Y C A N+ G S V L V P P V + LEC
Sbjct: 308 YCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIAVLEC-KVPN 366
Query: 3140 PRSSARWTRISSTPAKLEQRTYGLMDSHAV--LQISSAKPSDAGTYVCLAQNALGTAQKQ 3197
R W R L R Y ++ V L I K D G Y+C + + T
Sbjct: 367 SRIPTAWFR--EDQRLLPCRKYEQIEEGTVRRLIIHRLKADDDGIYLCEMRGRVRT---- 420
Query: 3198 VEVIVDTGAMAPGAPQ----VQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLP 3253
V + G + P+ ++ E A L VE TL G WS+ LP
Sbjct: 421 VANVTVKGPILKRLPRKLDVLEGENAVLLVE-----TLEAGVEG------RWSRDGEELP 469
Query: 3254 WQHRLEG---DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVE----SPPYATTVPE 3306
+ L++P V ++D+G+ T G++ T +L V+ SPP + E
Sbjct: 470 VICQSSSGHMHALVLPGVTREDAGE----VTFSLGNSRTTTLLRVKCVKHSPPGPPILAE 525
Query: 3307 HASVQAGETVQLQCLAHGTPPLTF----QWSRVGSS--LPGRATARNELLHFERAAPEDS 3360
+ P F + VGS + + + +
Sbjct: 526 MFKGHKNTVLLTWKPPEPAPETPFIYRLERQEVGSEDWIQCFSIEKAGAVEVPGDCVPSE 585
Query: 3361 GRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFH 3420
G YR R+ G + ++ G +P + AG LE + +
Sbjct: 586 GDYRFRICTVSGHGRS-PHVVFHGSAHLVPTARLVAG----------LEDVQVYDGEDAV 634
Query: 3421 CAVPSDRGTQLRWFKEGGQL---PPGHSVQDGVLRIQNLDQSCQGTYICQA--HGPWGK- 3474
++ Q WF G +L P V+ G LR + + Q I A H G
Sbjct: 635 FSLDLSTIIQGTWFLNGEELKSNEPEGQVEPGALRYRIEQKGLQHRLILHAVKHQDSGAL 694
Query: 3475 -------AQASAQLVIQALPSVLINIRTSVQ-TVVVGHAVEFECLALGDPKPQVTWSKVG 3526
Q SA L IQ P +++ + V T V C L TW K G
Sbjct: 695 VGFSCPGVQDSAALTIQESPVHILSPQDRVSLTFTTSERVVLTC-ELSRVDFPATWYKDG 753
Query: 3527 GHLRPG---IVQSGG---VVRIAHVELADAGQYRCTATNAAG----TTQSHVLLLVQALP 3576
+ +V+ G + + ++ D+G++ C + T Q + +V
Sbjct: 754 QKVEESELLVVKMDGRKHRLILPEAKVQDSGEFECRTEGVSAFFGVTVQDPPVHIVDPRE 813
Query: 3577 QISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR---LEN----NMLMLP 3629
+ V + C P + W K DG +S LEN L+LP
Sbjct: 814 HVF----VHAITSECVMLACEVDREDAP-VRWYK-DGQEVEESDFVVLENEGPHRRLVLP 867
Query: 3630 SVRPQDAGTYVCTA 3643
+ +P D G + C A
Sbjct: 868 ATQPSDGGEFQCVA 881
Score = 81.6 bits (200), Expect = 2e-14
Identities = 92/341 (26%), Positives = 124/341 (36%), Gaps = 72/341 (21%)
Query: 3389 LPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP------- 3441
+ A+S GS P P+ GA E C V + + W K G QL
Sbjct: 1 MKASSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSF 60
Query: 3442 PGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI------------------ 3483
P + G+L L G Y+C+A G+A A+A + +
Sbjct: 61 PADGAEHGLLLTAALPTDA-GVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 119
Query: 3484 -----QALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVG---------GH- 3528
+ P L R+ Q V+ G V C A G P+P + W K G H
Sbjct: 120 SPGSGEGAPVFLTGPRS--QWVLRGAEVVLTCRAGGLPEPTLYWEKDGMALDEVWDSSHF 177
Query: 3529 -LRPGIVQSGG----VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI--SMP 3581
L+PG + G +RI L D+G Y C A NA G Q+ LL V P+ + P
Sbjct: 178 ALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPPESPPADP 237
Query: 3582 QEVRVPA---------------GSAAVFPCIASGYPTPDISWSKLDGSLPPDSRL----- 3621
E P G A F C G P P+I W L PD R
Sbjct: 238 DEAPAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEWHWEGRPLLPDRRRLMYRD 297
Query: 3622 --ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPE 3660
+L + + +D G YVC A N G+ + L V E
Sbjct: 298 RDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKE 338
Score = 47.0 bits (110), Expect = 4e-04
Identities = 28/110 (25%), Positives = 44/110 (40%), Gaps = 9/110 (8%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTL 464
PP + PR ++ G CV +G P P++ W + + R++ ++G L
Sbjct: 11 PPCFLRFPRP-VRVVSGAEAELKCVVLGEPPPVVVWEKGGQQLAASERLSFPADGAEHGL 69
Query: 465 IIRDVKESDQGAYTCEAMNARGMVFGI--------PDGVLELVPQRGPCP 506
++ +D G Y C A NA G + P EL P P P
Sbjct: 70 LLTAALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPASDPELQPAERPLP 119
Score = 38.9 bits (89), Expect = 0.11
Identities = 35/113 (30%), Positives = 43/113 (38%), Gaps = 10/113 (8%)
Query: 383 PASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRL 442
PAS + ++ P S G P +T PR S RG V TC A G+P P + W
Sbjct: 105 PASDPELQPAERPLPSPGSGEGAPVFLTGPR-SQWVLRGAEVVLTCRAGGLPEPTLYWEK 163
Query: 443 N-------W--GHIPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+ W H P G L I + D G Y C A NA G
Sbjct: 164 DGMALDEVWDSSHFALQPGRAEDGPGASLALRILAARLPDSGVYVCHARNAHG 216
Score = 37.4 bits (85), Expect = 0.33
Identities = 22/82 (26%), Positives = 37/82 (45%), Gaps = 2/82 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGT 463
+P +V P + ++ + G T TF C + + W + + PR+ + + G R
Sbjct: 1627 VPVTIVRGPHD-LEVTEGDTATFEC-ELSQALADVTWEKDGNALTPSPRLRLQALGTRRL 1684
Query: 464 LIIRDVKESDQGAYTCEAMNAR 485
L +R SD G Y+C AR
Sbjct: 1685 LQLRRCGPSDAGTYSCAVGTAR 1706
Score = 36.6 bits (83), Expect = 0.56
Identities = 24/88 (27%), Positives = 37/88 (42%), Gaps = 8/88 (9%)
Query: 405 PPQVVTPPR---ESIQASRGQTVTFTCVAIGVPTPIINWRLNWGH---IPSHPRVTVTSE 458
P VV P + ++ + G+ F C +G P P I W +W +P R+
Sbjct: 241 PAPVVEPLKCAPKTFWVNEGKHAKFRCYVMGKPEPEIEW--HWEGRPLLPDRRRLMYRDR 298
Query: 459 GGRGTLIIRDVKESDQGAYTCEAMNARG 486
G L + + D+G Y C A N+ G
Sbjct: 299 DGGFVLKVLYCQAKDRGLYVCAARNSAG 326
>gi|139948432 adlican [Homo sapiens]
Length = 2828
Score = 208 bits (529), Expect = 1e-52
Identities = 264/1063 (24%), Positives = 401/1063 (37%), Gaps = 170/1063 (15%)
Query: 1646 TGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPP 1705
+G + + + G P L E P ++ P V C+ +G P
Sbjct: 1826 SGSFHQSSSKFFAGGPPASKFWSLGEK---PQILTKSPQTVSVTAETDTVFPCEATGKPK 1882
Query: 1706 HYFYWSREDGRPV--PSGTQQRHQ---GSELHFPSVQPSDAGVYICTCRNLHQSNTSRAE 1760
+ W++ + P+ QR + L VQ D G Y+CT NLH R
Sbjct: 1883 PFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH--GLDRMV 1940
Query: 1761 LLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVW----TRLHNGKLPT 1816
+L++ +P + + +V G + C AK +PA + W R+ P
Sbjct: 1941 VLLSVTVQQP-QILASHYQDVTVYLGDTIAMECLAKG-TPAPQISWIFPDRRVWQTVSPV 1998
Query: 1817 R---AMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPP 1873
+ N L+I+ SD G Y C SN D LHV A PV IH
Sbjct: 1999 EGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAA----LPPV--IHQE 2052
Query: 1874 QL---TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHG-------GILRLPAV 1923
+L ++ PG C+A +P P++ W G G Q+ +HG G L + +
Sbjct: 2053 KLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNL 2112
Query: 1924 EPTDQAQYLCRAHSSAGQQVARAVLHV-HGGGGPRVQ-VSPERTQVHAGRTVRLYCRAAG 1981
P D +Y C A + G L+V R+ SP RT V G T++L C A+G
Sbjct: 2113 APKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGTLKLDCSASG 2172
Query: 1982 VPSATITWRKEGGSLPPQARSERTDI-----ATLLIPAITTADAGFYLCVATSPAGTAQA 2036
P I WR + S + I TL++ ++T DAG YLCVA + G
Sbjct: 2173 DPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYV 2232
Query: 2037 RIQVVVLSASDASPPPVKI---ESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL-- 2091
++V D P KI E + V G L ++CV G + +++W GSL
Sbjct: 2233 VLKV------DVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVN 2286
Query: 2092 ------------PPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTH 2139
+ + L +V + G+Y C EN G E + V V+
Sbjct: 2287 SFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVV---- 2342
Query: 2140 SGPSYTPVPGSTRPIRIEPS---SSHVAEGQTLDLNCVVPGQAHAQVTW----HKRGGSL 2192
T P I + V G + + C G+ +VTW +K +
Sbjct: 2343 -----------TAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTS 2391
Query: 2193 PARHQTH--GSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPI--PPVR 2248
++Q + G+LL + + +DSG Y C V ++G E V I +V P I P
Sbjct: 2392 SEKYQIYQDGTLL-IQKAQRSDSGNYTCLVRNSAG--EDRKTVWIHVNVQPPKINGNPNP 2448
Query: 2249 IESSSSTVAEGQTLDLSCVVAGQAHAQVTW-YKRGGSLPA-----RHQVRGS-RLYIFQA 2301
I + A G + C G +V W + G LPA R V G+ L I
Sbjct: 2449 ITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSL 2508
Query: 2302 SPADAGQYVCRASN-GMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVA--EGQTL 2358
+D+ Q VC A N G EA + + +T + +PI +P S ++ G T+
Sbjct: 2509 RKSDSVQLVCMARNEGGEARLILQLTVLEPME--------KPIFHDPISEKITAMAGHTI 2560
Query: 2359 DLNCVVPGQSHAQVTW-------HKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVLG 2411
LNC G + W + G L + +L + S D+G Y C
Sbjct: 2561 SLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARN 2620
Query: 2412 SSVPLEASVLVTIEPAGSVPALGVTPTVRIE-SSSSQVAEGQTLDLNCLVAGQAHAQVTW 2470
++ E V + + G+ P + + + G+TL L C G + +W
Sbjct: 2621 AAGHTERLVSLKV---------GLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSW 2671
Query: 2471 ------HKRGGSLPAR-HQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQR 2523
H G R + L + + + D G YVCR+ G S+ V +
Sbjct: 2672 TLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIV--- 2728
Query: 2524 LSGSHSQGVAYPVRIESSSASL---ANGHTLDLNCLVASQAPHTITWYKRGGSLPSRH-- 2578
+AYP RI S + G+T+ LNC+ ITW LP +
Sbjct: 2729 --------IAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITW-----ELPDKSHL 2775
Query: 2579 ------QIVGSRLRIPQ-------VTPADSGEYVCHVSNGAGS 2608
++ G+R PQ T D+G Y C N GS
Sbjct: 2776 KAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGS 2818
Score = 186 bits (471), Expect = 6e-46
Identities = 237/1025 (23%), Positives = 378/1025 (36%), Gaps = 155/1025 (15%)
Query: 1769 KPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPT---RAMDF---- 1821
KP +T Q + SV D F C A K P + WT++ G L T R F
Sbjct: 1852 KPQILTKSPQ-TVSVTAETDTVFPCEATGK-PKPFVTWTKVSTGALMTPNTRIQRFEVLK 1909
Query: 1822 NGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAP-VVSIHPPQLTVQPG 1880
NG L IR VQ+ D G Y+CT SN+ +D+ L V T+ P +++ H +TV G
Sbjct: 1910 NGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSV----TVQQPQILASHYQDVTVYLG 1965
Query: 1881 QLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGI-------LRLPAVEPTDQAQYLC 1933
C A G+P P + W + + G I L + +D+ Y C
Sbjct: 1966 DTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKC 2025
Query: 1934 RAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEG 1993
A ++AG LHV Q E + G ++ ++C A P ++ W
Sbjct: 2026 VASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGD 2085
Query: 1994 GSLPPQARSERTDI-----ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDA 2048
G+ ++ ++ TL I + D+G Y CVA + G+A+ +Q+ V A+
Sbjct: 2086 GTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA-- 2143
Query: 2049 SPPPVKIESSSPSVTE---GQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQVHGSRLR-- 2103
+I +SP T+ G TL L+C +G ++ W + SR++
Sbjct: 2144 --ANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVF 2201
Query: 2104 ------LPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIE 2157
+ V+ D+G+Y+C N G + V V+ +P +IE
Sbjct: 2202 ANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVV---------------MKPAKIE 2246
Query: 2158 PSSSH---VAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQT--------------HG 2200
+ V G L ++CV G + +++W GSL +
Sbjct: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306
Query: 2201 SLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQ 2260
L ++V + G+Y C G E V V V+ P + V G
Sbjct: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRV----KVVTAPATIRNKTYLAVQVPYGD 2362
Query: 2261 TLDLSCVVAGQAHAQVTWYKRGGSL----PARHQV-RGSRLYIFQASPADAGQYVCRASN 2315
+ ++C G+ +VTW + ++Q+ + L I +A +D+G Y C N
Sbjct: 2363 VVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRN 2422
Query: 2316 GM-EASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTW 2374
E TV + N+ P + P I A G ++C G +V W
Sbjct: 2423 SAGEDRKTVWI----HVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKAEGIPTPRVLW 2478
Query: 2375 -HKRGGSLPV-----RHQTHGS-LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPA 2427
G LP R HG+ L + +DS + VC + +T+
Sbjct: 2479 AFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEP 2538
Query: 2428 GSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTW-------HKRGGSLPAR 2480
P + +I + + G T+ LNC AG + W + G L
Sbjct: 2539 MEKPIFHDPISEKITAMA-----GHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRF 2593
Query: 2481 HQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIES 2540
+ L + ++ D+G Y C ++G E V + + + +
Sbjct: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQY---------H 2644
Query: 2541 SSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVG-------SRLRIPQVTPA 2593
+ S+ NG TL L C +W G Q +G L + + +
Sbjct: 2645 NLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVF 2704
Query: 2594 DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVV---EGQTLDLN 2650
D G YVC + G TS+ V + ++ P RI S V+ G T+ LN
Sbjct: 2705 DRGTYVCRMETEYGPSVTSIPVIV----------IAYPPRITSEPTPVIYTRPGNTVKLN 2754
Query: 2651 CVVARQPQAIITWYKRGGSLPSR-HQTHGSHLRLH--------------QMSVADSGEYV 2695
C+ P+A ITW LP + H G RL+ + D+G Y
Sbjct: 2755 CMAMGIPKADITW-----ELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYK 2809
Query: 2696 CRANN 2700
C A N
Sbjct: 2810 CMAKN 2814
Score = 181 bits (459), Expect = 1e-44
Identities = 241/992 (24%), Positives = 382/992 (38%), Gaps = 129/992 (13%)
Query: 2749 VVPG---QAHAQVTWHKRGG--SLPSHH--QTRGS-RLRLHHV----SPADSGEYVCRVM 2796
V+PG + H+ T+H G + P H QT GS L ++ S S ++ +
Sbjct: 1764 VIPGSYNRIHSHSTFHLDFGPPAPPLLHTPQTTGSPSTNLQNIPMVSSTQSSISFITSSV 1823
Query: 2797 GSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIE-PSSSRVAEGQTLDLKCVVPGQAH 2855
SSG S A G A + G P I + P + V C G+
Sbjct: 1824 QSSGSFHQSSSKFF-AGGPPASKFWSLGEKPQILTKSPQTVSVTAETDTVFPCEATGKPK 1882
Query: 2856 AQVTWHK--RGGNLPARHQVH------GPLLRLNQVSPADSGEYSCQVTGSSGTLEASVL 2907
VTW K G + ++ L + +V D G+Y C + G VL
Sbjct: 1883 PFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVL 1942
Query: 2908 VTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTW-------YK 2960
+++ P + + +Y+ G T+ + C+ G Q++W ++
Sbjct: 1943 LSVTVQQPQILASHYQDVTVYL---------GDTIAMECLAKGTPAPQISWIFPDRRVWQ 1993
Query: 2961 RGGSLPARHQTHGSQ-LRLHLVSPADSGEYVCRAASGPGPEQEAS--FTVTVPPSEGSSY 3017
+ R H ++ L + S +D G Y C A++ G + A +PP +
Sbjct: 1994 TVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPV---IH 2050
Query: 3018 RLRSPVISIDPPSS-----TVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN 3072
+ + IS+ P S T + S + ++ DG +Q L N+ + PN
Sbjct: 2051 QEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQI------RPSQFLHGNLFVFPN 2104
Query: 3073 GSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVH-GPPTVSVLPEGP--VWVKVGKA 3129
G++ I P + G Y CVA+N G A+ V L+V + P V+ G
Sbjct: 2105 GTLY-IRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAANARITGTSPRRTDVRYGGT 2163
Query: 3130 VTLECVSAGEPRSSARWTRIS-STPAKLEQRTYGLMDS------HAVLQISSAKPSDAGT 3182
+ L+C ++G+P W RI P+K DS + L + S DAG
Sbjct: 2164 LKLDCSASGDP-----WPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGD 2218
Query: 3183 YVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPT 3242
Y+C+A+N +G ++V V M P + EE + V G + C ATG P P
Sbjct: 2219 YLCVARNKVGDDYVVLKVDV---VMKPAKIE-HKEENDHKVFYGGDLKVDCVATGLPNPE 2274
Query: 3243 IHWSKLRSPLPWQHRLEGD--------------TLIIPRVAQQDSGQYICNATSPAGHAE 3288
I WS L D TL V ++ G Y C A + G E
Sbjct: 2275 ISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDE 2334
Query: 3289 ATIILHVESPPYATTVPEHASVQA--GETVQLQCLAHGTPPLTFQWSRVGSSLPGRATAR 3346
+ + V + P + +VQ G+ V + C A G P W + + ++ +
Sbjct: 2335 MRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEK 2394
Query: 3347 NEL-----LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPT 3401
++ L ++A DSG Y C V N G + V P + P
Sbjct: 2395 YQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNPNP------ 2448
Query: 3402 VQVTPQLETKSIGASVEFHCAVPSDRGTQLRW-FKEGGQLPP---GHSVQ---DGVLRIQ 3454
+T E + G+ C ++ W F EG LP G+ + +G L I+
Sbjct: 2449 --ITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIR 2506
Query: 3455 NLDQSCQGTYICQAHGPWGKAQASAQL-VIQALPSVLINIRTSVQ-TVVVGHAVEFECLA 3512
+L +S +C A G+A+ QL V++ + + + S + T + GH + C A
Sbjct: 2507 SLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNCSA 2566
Query: 3513 LGDPKPQVTWS-------KVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQ 3565
G P P + W + G L+ ++ G++ I+ + DAG YRC A NAAG T+
Sbjct: 2567 AGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTE 2626
Query: 3566 SHVLLLVQALPQISMPQE--VRVPAGSAAVFPCIASGYPTPDISWSKLDG-------SLP 3616
V L V P+ + V + G PC G SW+ +G +L
Sbjct: 2627 RLVSLKVGLKPEANKQYHNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLG 2686
Query: 3617 PDSRLENNMLMLPSVRPQDAGTYVCTATNRQG 3648
S L+N L + D GTYVC G
Sbjct: 2687 RVSLLDNGTLTVREASVFDRGTYVCRMETEYG 2718
Score = 178 bits (451), Expect = 1e-43
Identities = 192/789 (24%), Positives = 302/789 (38%), Gaps = 106/789 (13%)
Query: 2946 CVVPGQAHAQVTWYKRGGSLPARHQTH--------GSQLRLHLVSPADSGEYVCRAASGP 2997
C G+ VTW K T L + V D G+Y+C A++
Sbjct: 1875 CEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLH 1934
Query: 2998 GPEQEA---SFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISL 3054
G ++ S TV P S Y+ TV G + +CL AP +
Sbjct: 1935 GLDRMVVLLSVTVQQPQILASHYQ-----------DVTVYLGDTIAMECLAKGTPAP-QI 1982
Query: 3055 EWKTRNQELEDNVHISPNGSIITIVGTRP--------SNHGTYRCVASNAYGVAQSVVNL 3106
W ++ + V SP IT+ R S+ G Y+CVASNA G + L
Sbjct: 1983 SWIFPDRRVWQTV--SPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRL 2040
Query: 3107 SVHG-PPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYG--L 3163
V PP + + + G ++ + C + P S RW T + Q +G
Sbjct: 2041 HVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLF 2100
Query: 3164 MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV 3223
+ + L I + P D+G Y C+A N +G+A++ V++ V A A V
Sbjct: 2101 VFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAA--NARITGTSPRRTDV 2158
Query: 3224 EAGHTATLRCSATGSPAPTIHWS-----KLRSPLPWQHRLE---GDTLIIPRVAQQDSGQ 3275
G T L CSA+G P P I W + + + R++ TL++ V +D+G
Sbjct: 2159 RYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANGTLVVKSVTDKDAGD 2218
Query: 3276 YICNATSPAGHAEATIILHVESPPYATTVPEHAS--VQAGETVQLQCLAHGTPPLTFQWS 3333
Y+C A + G + + V P E V G +++ C+A G P WS
Sbjct: 2219 YLCVARNKVGDDYVVLKVDVVMKPAKIEHKEENDHKVFYGGDLKVDCVATGLPNPEISWS 2278
Query: 3334 RVGSSL---------PGRATAR-----NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQ 3379
SL G T R N L+F + G Y C N+VG E +
Sbjct: 2279 LPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMREEGDYTCFAENQVGKDEMRVR 2338
Query: 3380 LLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQ 3439
+ V P ++ + A P G V C + ++ W +
Sbjct: 2339 VKVVTAPATIRNKTYLAVQVP------------YGDVVTVACEAKGEPMPKVTWLSPTNK 2386
Query: 3440 LPPGHS-----VQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLI--- 3491
+ P S QDG L IQ +S G Y C G+ + + + + P +
Sbjct: 2387 VIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGEDRKTVWIHVNVQPPKINGNP 2446
Query: 3492 NIRTSVQTVVVGHAVEF-ECLALGDPKPQVTWSKVGGHLRPG-------IVQSGGVVRIA 3543
N T+V+ + G + + +C A G P P+V W+ G + P V G + I
Sbjct: 2447 NPITTVREIAAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIR 2506
Query: 3544 HVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMP-------QEVRVPAGSAAVFPC 3596
+ +D+ Q C A N G ++ ++L + L + P +++ AG C
Sbjct: 2507 SLRKSDSVQLVCMARNEGG--EARLILQLTVLEPMEKPIFHDPISEKITAMAGHTISLNC 2564
Query: 3597 IASGYPTPDISWSKLDGS-LPPDSRLE------NNMLMLPSVRPQDAGTYVCTATNRQGK 3649
A+G PTP + W +G+ L +L+ + ML + + DAG Y C A N G
Sbjct: 2565 SAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGH 2624
Query: 3650 VKAFAHLQV 3658
+ L+V
Sbjct: 2625 TERLVSLKV 2633
Score = 177 bits (449), Expect = 2e-43
Identities = 238/1036 (22%), Positives = 382/1036 (36%), Gaps = 171/1036 (16%)
Query: 1961 SPERTQVHAGRTVRLYCRAAGVPSATITWRK--EGGSLPPQARSERTDI---ATLLIPAI 2015
SP+ V A C A G P +TW K G + P R +R ++ TL+I +
Sbjct: 1859 SPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKV 1918
Query: 2016 TTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVA 2075
D G Y+C A++ G + VV+LS + P + +V G T+ + C+
Sbjct: 1919 QVQDRGQYMCTASNLHGLDR---MVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAK 1975
Query: 2076 GSAHAQVTW-------YRRGGSLPPHTQVHGSR-LRLPQVSPADSGEYVCRVENGSGPKE 2127
G+ Q++W ++ + +H +R L + + S +D G Y C N +G
Sbjct: 1976 GTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASNAAGADS 2035
Query: 2128 ASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHK 2187
+I + V +P ++E S + G ++ ++C V W
Sbjct: 2036 LAIRLHV----------AALPPVIHQEKLENIS--LPPGLSIHIHCTAKAAPLPSVRWVL 2083
Query: 2188 RGGSLPARHQ-THGSL-------LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASV 2239
G+ Q HG+L L + + P DSG Y C G +V + ++ +
Sbjct: 2084 GDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAA 2143
Query: 2240 IPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVRG-----S 2294
I + V G TL L C +G ++ W LP++ + S
Sbjct: 2144 ANARITGT--SPRRTDVRYGGTLKLDCSASGDPWPRILW-----RLPSKRMIDALFSFDS 2196
Query: 2295 RLYIF--------QASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIE 2346
R+ +F + DAG Y+C A N + V +P +IE
Sbjct: 2197 RIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVV----------MKPAKIE 2246
Query: 2347 ---PSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLP---VRHQTHGSLLRLY----- 2395
+ +V G L ++CV G + +++W GSL ++ G + Y
Sbjct: 2247 HKEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNN 2306
Query: 2396 ------QASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSS-QV 2448
+ + G+Y C E V V + A PA T+R ++ + QV
Sbjct: 2307 GTLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTA---PA-----TIRNKTYLAVQV 2358
Query: 2449 AEGQTLDLNCLVAGQAHAQVTW----HKRGGSLPARHQVHGSRLRLLQVTP-ADSGEYVC 2503
G + + C G+ +VTW +K + ++Q++ L+Q +DSG Y C
Sbjct: 2359 PYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTC 2418
Query: 2504 RVVGSSGTQEASVLVTIQ---QRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQ 2560
V S+G +V + + +++G+ P I + A G ++C
Sbjct: 2419 LVRNSAGEDRKTVWIHVNVQPPKINGN-------PNPITTVREIAAGGSRKLIDCKAEGI 2471
Query: 2561 APHTITW-YKRGGSLPSRHQIVGSR--------LRIPQVTPADSGEYVCHVSNGAGSRET 2611
+ W + G LP+ + G+R L I + +DS + VC N G E
Sbjct: 2472 PTPRVLWAFPEGVVLPAPYY--GNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGG--EA 2527
Query: 2612 SLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGS-L 2670
LI+ + P PI S T + G T+ LNC A P + W G+ L
Sbjct: 2528 RLILQLTVLEPMEKPIFHDPI---SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDL 2584
Query: 2671 PSRHQTHGSH------LRLHQMSVADSGEYVCRANNNIDALE--ASIVISVSPSAGSPSA 2722
S Q + L + +S D+G Y C A N E S+ + + P A
Sbjct: 2585 QSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQY- 2643
Query: 2723 PGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRG------- 2775
+ + GETL L C PG + +W G QT G
Sbjct: 2644 ----------HNLVSIINGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDN 2693
Query: 2776 SRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSS 2835
L + S D G YVCR+ GP S+ V + A P P I P
Sbjct: 2694 GTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEP----TPVIYTRP-- 2747
Query: 2836 SRVAEGQTLDLKCVVPGQAHAQVTW------HKRGG---NLPARHQVHGP-LLRLNQVSP 2885
G T+ L C+ G A +TW H + G L +H L + +
Sbjct: 2748 -----GNTVKLNCMAMGIPKADITWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQ 2802
Query: 2886 ADSGEYSCQVTGSSGT 2901
D+G Y C G+
Sbjct: 2803 RDAGFYKCMAKNILGS 2818
Score = 159 bits (403), Expect = 4e-38
Identities = 149/597 (24%), Positives = 232/597 (38%), Gaps = 88/597 (14%)
Query: 3111 PPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISS----TPAKLEQRTYGLMDS 3166
P TVSV E C + G+P+ WT++S+ TP QR L
Sbjct: 1860 PQTVSVTAETDT--------VFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVL--K 1909
Query: 3167 HAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEE-AELTVEA 3225
+ L I + D G Y+C A N G + V + V PQ+ A ++TV
Sbjct: 1910 NGTLVIRKVQVQDRGQYMCTASNLHGLDRMVVLLSVTVQQ-----PQILASHYQDVTVYL 1964
Query: 3226 GHTATLRCSATGSPAPTIHWS-------KLRSPLPWQHRL-EGDTLIIPRVAQQDSGQYI 3277
G T + C A G+PAP I W + SP+ + L E TL I + D G Y
Sbjct: 1965 GDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYK 2024
Query: 3278 CNATSPAGHAEATIILHVESPPYATTVP--EHASVQAGETVQLQCLAHGTPPLTFQWS-- 3333
C A++ AG I LHV + P E+ S+ G ++ + C A P + +W
Sbjct: 2025 CVASNAAGADSLAIRLHVAALPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLG 2084
Query: 3334 -----RVGSSLPGRATA-RNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPG 3387
R L G N L+ AP+DSGRY C N VGSA QL VQ
Sbjct: 2085 DGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVGSARRTVQLNVQRAAA 2144
Query: 3388 SLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSVQ 3447
+ T +P+ G +++ C+ D ++ W +LP +
Sbjct: 2145 NARITG----------TSPRRTDVRYGGTLKLDCSASGDPWPRILW-----RLPSKRMID 2189
Query: 3448 -------------DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIR 3494
+G L ++++ G Y+C A G ++ + P+ + +
Sbjct: 2190 ALFSFDSRIKVFANGTLVVKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKE 2249
Query: 3495 TSVQTVVVGHAVEFECLALGDPKPQVTWS--------------KVGGHLRPGIVQSGGVV 3540
+ V G ++ +C+A G P P+++WS GG + +V + G +
Sbjct: 2250 ENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTL 2309
Query: 3541 RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQ---EVRVPAGSAAVFPCI 3597
V + + G Y C A N G + V + V P + V+VP G C
Sbjct: 2310 YFNEVGMREEGDYTCFAENQVGKDEMRVRVKVVTAPATIRNKTYLAVQVPYGDVVTVACE 2369
Query: 3598 ASGYPTPDISWSKLDGSLPPDSR-----LENNMLMLPSVRPQDAGTYVCTATNRQGK 3649
A G P P ++W + P S ++ L++ + D+G Y C N G+
Sbjct: 2370 AKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAGE 2426
Score = 155 bits (392), Expect = 8e-37
Identities = 228/1015 (22%), Positives = 360/1015 (35%), Gaps = 143/1015 (14%)
Query: 2736 SHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSR--------LRLHHVSPAD 2787
S AE +T+ C G+ VTW K TR R L + V D
Sbjct: 1864 SVTAETDTV-FPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQD 1922
Query: 2788 SGEYVCRVMGSSGPLEASVL--VTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLD 2845
G+Y+C G VL VT++ A H V G T+
Sbjct: 1923 RGQYMCTASNLHGLDRMVVLLSVTVQQPQILASHY-------------QDVTVYLGDTIA 1969
Query: 2846 LKCVVPGQAHAQVTW-------HKRGGNLPARHQVH-GPLLRLNQVSPADSGEYSCQVTG 2897
++C+ G Q++W + + R +H L + + S +D G Y C +
Sbjct: 1970 MECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCVASN 2029
Query: 2898 SSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVT 2957
++G S+ + + ++ P+ + I + G ++ ++C V
Sbjct: 2030 AAGA--DSLAIRLHVAALPPVIHQEKLENISLPP-------GLSIHIHCTAKAAPLPSVR 2080
Query: 2958 WYKRGGSLPARHQ-THGS-------QLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV 3009
W G+ Q HG+ L + ++P DSG Y C AA+ G A TV +
Sbjct: 2081 WVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAANLVG---SARRTVQL 2137
Query: 3010 PPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELED---- 3065
++ + + P + V+ G C P L W+ ++ + D
Sbjct: 2138 NVQRAAA---NARITGTSPRRTDVRYGGTLKLDCSASGDPWPRIL-WRLPSKRMIDALFS 2193
Query: 3066 ---NVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSV-HGPPTVSVLPEGP 3121
+ + NG+++ + + G Y CVA N G V+ + V P + E
Sbjct: 2194 FDSRIKVFANGTLV-VKSVTDKDAGDYLCVARNKVGDDYVVLKVDVVMKPAKIEHKEEND 2252
Query: 3122 VWVKVGKAVTLECVSAGEPRSSARWTR---------ISSTPAKLEQRTYGLMDSHAVLQI 3172
V G + ++CV+ G P W+ + S + + Y ++ ++ L
Sbjct: 2253 HKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRY-VVFNNGTLYF 2311
Query: 3173 SSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEA--GHTAT 3230
+ + G Y C A+N +G + +V V V T AP + L V+ G T
Sbjct: 2312 NEVGMREEGDYTCFAENQVGKDEMRVRVKVVT------APATIRNKTYLAVQVPYGDVVT 2365
Query: 3231 LRCSATGSPAPTIHW-SKLRSPLPWQHR----LEGDTLIIPRVAQQDSGQYICNATSPAG 3285
+ C A G P P + W S +P + TL+I + + DSG Y C + AG
Sbjct: 2366 VACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNYTCLVRNSAG 2425
Query: 3286 HAEATIILHVE--------SPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWS-RVG 3336
T+ +HV +P TTV E A+ G + C A G P W+ G
Sbjct: 2426 EDRKTVWIHVNVQPPKINGNPNPITTVREIAA--GGSRKLIDCKAEGIPTPRVLWAFPEG 2483
Query: 3337 SSLPG-----RATAR-NELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLP 3390
LP R T N L DS + C N+ G A QL V P P
Sbjct: 2484 VVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARNEGGEARLILQLTVLEPMEK-P 2542
Query: 3391 ATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW-------FKEGGQLPPG 3443
P T G ++ +C+ L W + G QL
Sbjct: 2543 IFHDPISEKITAMA---------GHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRF 2593
Query: 3444 HSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVG 3503
+ DG+L I L G Y C A G + L + P V +++ G
Sbjct: 2594 YHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQYHNLV-SIING 2652
Query: 3504 HAVEFECLALGDPKPQVTWSKVGGHLRPGIVQSG-------GVVRIAHVELADAGQYRCT 3556
++ C G + + +W+ G G G G + + + D G Y C
Sbjct: 2653 ETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTYVCR 2712
Query: 3557 ATNAAGTTQSHVLLLVQALPQ--ISMPQEV-RVPAGSAAVFPCIASGYPTPDISWSKLDG 3613
G + + + ++V A P S P V G+ C+A G P DI+W D
Sbjct: 2713 METEYGPSVTSIPVIVIAYPPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWELPDK 2772
Query: 3614 S---LPPDSRLENNMLMLPS-------VRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
S +RL N + P +DAG Y C A N G ++ V
Sbjct: 2773 SHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYIHV 2827
Score = 135 bits (341), Expect = 7e-31
Identities = 219/1055 (20%), Positives = 373/1055 (35%), Gaps = 204/1055 (19%)
Query: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYR--RGGSLPPHTQVH------GSRLRLPQVSPADS 2112
SVT C G VTW + G + P+T++ L + +V D
Sbjct: 1864 SVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDR 1923
Query: 2113 GEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE-----GQ 2167
G+Y+C N G + +SV T P +SH + G
Sbjct: 1924 GQYMCTASNLHGLDRMVVLLSV---TVQQPQIL--------------ASHYQDVTVYLGD 1966
Query: 2168 TLDLNCVVPGQAHAQVTW-------HKRGGSLPARHQTHGS-LLRLHQVTPADSGEYVCH 2219
T+ + C+ G Q++W + + R H + L + + + +D G Y C
Sbjct: 1967 TIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHENRTLSIKEASFSDRGVYKCV 2026
Query: 2220 VVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWY 2279
+G S+ + + + +P I ++E+ S + G ++ + C V W
Sbjct: 2027 ASNAAGA--DSLAIRLHVAALPPVIHQEKLENIS--LPPGLSIHIHCTAKAAPLPSVRWV 2082
Query: 2280 KRGGSLPARHQVRGSRLYIF--------QASPADAGQYVCRASNGMEASITVTVTGTQGA 2331
G+ Q L++F +P D+G+Y C A+N + + T
Sbjct: 2083 LGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAPKDSGRYECVAAN-----LVGSARRTVQL 2137
Query: 2332 NLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSL 2391
N+ A + + P + V G TL L+C G ++ W + + S
Sbjct: 2138 NVQRAAANARITGTSPRRTDVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSR 2197
Query: 2392 LRLY--------QASPADSGEYVCRVLGSSVPLEASVL---VTIEPAGSVPALGVTPTVR 2440
++++ + D+G+Y+C V + V + VL V ++PA
Sbjct: 2198 IKVFANGTLVVKSVTDKDAGDYLC-VARNKVGDDYVVLKVDVVMKPA---------KIEH 2247
Query: 2441 IESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL-------------PARHQV-HGS 2486
E + +V G L ++C+ G + +++W GSL R+ V +
Sbjct: 2248 KEENDHKVFYGGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNG 2307
Query: 2487 RLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSS---A 2543
L +V + G+Y C G E V V + V P I + +
Sbjct: 2308 TLYFNEVGMREEGDYTCFAENQVGKDEMRVRVKV-----------VTAPATIRNKTYLAV 2356
Query: 2544 SLANGHTLDLNCLVASQAPHTITWYKRGGSL----PSRHQIV-GSRLRIPQVTPADSGEY 2598
+ G + + C + +TW + ++QI L I + +DSG Y
Sbjct: 2357 QVPYGDVVTVACEAKGEPMPKVTWLSPTNKVIPTSSEKYQIYQDGTLLIQKAQRSDSGNY 2416
Query: 2599 VCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVE-----GQTLDLNCVV 2653
C V N AG ++ + HV P I + T V G ++C
Sbjct: 2417 TCLVRNSAGEDRKTVWI--------HVNVQPPKINGNPNPITTVREIAAGGSRKLIDCKA 2468
Query: 2654 ARQPQAIITW-YKRGGSLPS-----RHQTHGS-HLRLHQMSVADSGEYVCRANNNIDALE 2706
P + W + G LP+ R HG+ L + + +DS + VC A N + E
Sbjct: 2469 EGIPTPRVLWAFPEGVVLPAPYYGNRITVHGNGSLDIRSLRKSDSVQLVCMARN--EGGE 2526
Query: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWH----- 2761
A +++ ++ P PI S G T+ LNC G + W
Sbjct: 2527 ARLILQLTVLEPMEK-PIFHDPI---SEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGT 2582
Query: 2762 --KRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLE--ASVLVTIEASGSSA 2817
+ G L + L + +S D+G Y C ++G E S+ V ++ +
Sbjct: 2583 DLQSGQQLQRFYHKADGMLHISGLSSVDAGAYRCVARNAAGHTERLVSLKVGLKPEANKQ 2642
Query: 2818 VHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGP- 2876
H + + G+TL L C PG + +W LP + GP
Sbjct: 2643 YH--------------NLVSIINGETLKLPCTPPGAGQGRFSW-----TLPNGMHLEGPQ 2683
Query: 2877 -----------LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQ 2925
L + + S D G Y C++ G S+ V + P P
Sbjct: 2684 TLGRVSLLDNGTLTVREASVFDRGTYVCRMETEYGPSVTSIPVIVIAYPPRITSEP---T 2740
Query: 2926 PIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR-HQTHGSQLRLH----- 2979
P+ + G T+ LNC+ G A +TW LP + H G Q RL+
Sbjct: 2741 PVI------YTRPGNTVKLNCMAMGIPKADITW-----ELPDKSHLKAGVQARLYGNRFL 2789
Query: 2980 ---------LVSPADSGEYVCRAASGPGPEQEASF 3005
+ D+G Y C A + G + + ++
Sbjct: 2790 HPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTY 2824
Score = 97.8 bits (242), Expect = 2e-19
Identities = 83/325 (25%), Positives = 133/325 (40%), Gaps = 37/325 (11%)
Query: 3367 VTNKVGSAEAFAQLLVQGPPGSLPATSI-PAGSTPTVQVTPQLETKSIGASVE--FHCAV 3423
+T+ V S+ +F Q + G PA+ G P + +T +T S+ A + F C
Sbjct: 1819 ITSSVQSSGSFHQSSSKFFAGGPPASKFWSLGEKPQI-LTKSPQTVSVTAETDTVFPCEA 1877
Query: 3424 PSDRGTQLRWFK--EGGQLPPGHSVQ------DGVLRIQNLDQSCQGTYICQAHGPWGKA 3475
+ W K G + P +Q +G L I+ + +G Y+C A G
Sbjct: 1878 TGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGTLVIRKVQVQDRGQYMCTASNLHGLD 1937
Query: 3476 QASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTW-----------SK 3524
+ L + ++ TV +G + ECLA G P PQ++W S
Sbjct: 1938 RMVVLLSVTVQQPQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSP 1997
Query: 3525 VGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQE- 3583
V G + + + I +D G Y+C A+NAAG + L V ALP + ++
Sbjct: 1998 VEGRIT---LHENRTLSIKEASFSDRGVYKCVASNAAGADSLAIRLHVAALPPVIHQEKL 2054
Query: 3584 --VRVPAGSAAVFPCIASGYPTPDISWSKLDGS-LPPDSRLENNMLMLPS-------VRP 3633
+ +P G + C A P P + W DG+ + P L N+ + P+ + P
Sbjct: 2055 ENISLPPGLSIHIHCTAKAAPLPSVRWVLGDGTQIRPSQFLHGNLFVFPNGTLYIRNLAP 2114
Query: 3634 QDAGTYVCTATNRQGKVKAFAHLQV 3658
+D+G Y C A N G + L V
Sbjct: 2115 KDSGRYECVAANLVGSARRTVQLNV 2139
Score = 58.2 bits (139), Expect = 2e-07
Identities = 47/192 (24%), Positives = 76/192 (39%), Gaps = 22/192 (11%)
Query: 1876 TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQ--------IHGGILRLPAVEPTD 1927
TV G + C+ S +P++ W G L A + G LR+ ++EP+D
Sbjct: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
Query: 1928 QAQYLCRAH--SSAGQQVARAVLHVHGGGGPRVQVSPERTQV---HAGRTVRLYCRAAGV 1982
Y C A + V R ++ P Q + + T + G +V L C A +
Sbjct: 550 SGLYQCIAQVRDEMDRMVYRVLVQ-----SPSTQPAEKDTVTIGKNPGESVTLPCNALAI 604
Query: 1983 PSATITW----RKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARI 2038
P A ++W R+ L + TL IP + +D+G+Y CVA + G +
Sbjct: 605 PEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTV 664
Query: 2039 QVVVLSASDASP 2050
+ V P
Sbjct: 665 GITVTKKGSGLP 676
Score = 56.2 bits (134), Expect = 7e-07
Identities = 53/190 (27%), Positives = 77/190 (40%), Gaps = 22/190 (11%)
Query: 1688 VPQGGSHSLRCQVSGSPPHYFYWSREDGRPV------PSGTQQRHQGSELHFPSVQPSDA 1741
V +GG L C V S +W DG + P L S++PSD+
Sbjct: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
Query: 1742 GVYICTCRNLHQSNTSRAELLVTEAPSKPI---TVTVEEQRSQSVRPGADVTFICTAKSK 1798
G+Y C + + + +LV ++P TVT+ + PG VT C A +
Sbjct: 551 GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKN------PGESVTLPCNALAI 604
Query: 1799 SPAYTLVWT----RLHNGKLPTRAMDF--NGILTIRNVQLSDAGTYVCTGSNMFAMDQGT 1852
A+ L W R+ N T + NG L+I VQ+SD+G Y C N D T
Sbjct: 605 PEAH-LSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFT 663
Query: 1853 ATLHVQASGT 1862
+ V G+
Sbjct: 664 VGITVTKKGS 673
Score = 53.1 bits (126), Expect = 6e-06
Identities = 45/171 (26%), Positives = 68/171 (39%), Gaps = 21/171 (12%)
Query: 3498 QTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG---------IVQSGGVVRIAHVELA 3548
QTV+ G + C P + W G + + S G +RI +E +
Sbjct: 489 QTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPS 548
Query: 3549 DAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVPAGS----AAVFPCIASGYPTP 3604
D+G Y+C A + +LVQ+ P ++ V G + PC A P
Sbjct: 549 DSGLYQCIAQVRDEMDRMVYRVLVQS-PSTQPAEKDTVTIGKNPGESVTLPCNALAIPEA 607
Query: 3605 DISW----SKLDGSLPPDSR---LENNMLMLPSVRPQDAGTYVCTATNRQG 3648
+SW ++ L S L N L +P V+ D+G Y C A N+QG
Sbjct: 608 HLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
Score = 48.9 bits (115), Expect = 1e-04
Identities = 39/131 (29%), Positives = 60/131 (45%), Gaps = 15/131 (11%)
Query: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV--EAGH 3227
L+I S +PSD+G Y C+AQ + V+V + + P AE+ +T+ G
Sbjct: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQP------AEKDTVTIGKNPGE 593
Query: 3228 TATLRCSATGSPAPTIHW----SKLRSPL---PWQHRLEGDTLIIPRVAQQDSGQYICNA 3280
+ TL C+A P + W ++ + L + L TL IP+V DSG Y C A
Sbjct: 594 SVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
Query: 3281 TSPAGHAEATI 3291
+ G T+
Sbjct: 654 VNQQGADHFTV 664
Score = 48.1 bits (113), Expect = 2e-04
Identities = 25/84 (29%), Positives = 43/84 (51%), Gaps = 2/84 (2%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINW-RLNWGHIPS-HPRVTVTSEGGRGT 463
PQ++T +++ + F C A G P P + W +++ G + + + R+ GT
Sbjct: 1853 PQILTKSPQTVSVTAETDTVFPCEATGKPKPFVTWTKVSTGALMTPNTRIQRFEVLKNGT 1912
Query: 464 LIIRDVKESDQGAYTCEAMNARGM 487
L+IR V+ D+G Y C A N G+
Sbjct: 1913 LVIRKVQVQDRGQYMCTASNLHGL 1936
Score = 47.0 bits (110), Expect = 4e-04
Identities = 28/86 (32%), Positives = 41/86 (47%), Gaps = 8/86 (9%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINW----RLNWGHI-PSHPRVTVTSEGG 460
PQ++ + + G T+ C+A G P P I+W R W + P R+T+
Sbjct: 1950 PQILASHYQDVTVYLGDTIAMECLAKGTPAPQISWIFPDRRVWQTVSPVEGRITLHE--- 2006
Query: 461 RGTLIIRDVKESDQGAYTCEAMNARG 486
TL I++ SD+G Y C A NA G
Sbjct: 2007 NRTLSIKEASFSDRGVYKCVASNAAG 2032
Score = 46.6 bits (109), Expect = 5e-04
Identities = 59/242 (24%), Positives = 85/242 (35%), Gaps = 36/242 (14%)
Query: 1630 SLGAGGYRCTACEP-GYTGQYCEQCGPGYVGNPSVQGGQCLPETNQAPLVVEVHPARSIV 1688
S+ AG YRC A G+T + S++ G PE N+ + H SI+
Sbjct: 2608 SVDAGAYRCVARNAAGHTERLV-----------SLKVG-LKPEANK-----QYHNLVSII 2650
Query: 1689 PQGGSHSLRCQVSGSPPHYFYWSREDGR----PVPSGTQQRHQGSELHFPSVQPSDAGVY 1744
G + L C G+ F W+ +G P G L D G Y
Sbjct: 2651 -NGETLKLPCTPPGAGQGRFSWTLPNGMHLEGPQTLGRVSLLDNGTLTVREASVFDRGTY 2709
Query: 1745 ICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTL 1804
+C + + + ++V P + +T E RPG V C A P +
Sbjct: 2710 VCRMETEYGPSVTSIPVIVIAYPPR---ITSEPTPVIYTRPGNTVKLNCMAMG-IPKADI 2765
Query: 1805 VWTRLHNGKLPT---------RAMDFNGILTIRNVQLSDAGTYVCTGSNMFAMDQGTATL 1855
W L R + G LTI++ DAG Y C N+ D T +
Sbjct: 2766 TWELPDKSHLKAGVQARLYGNRFLHPQGSLTIQHATQRDAGFYKCMAKNILGSDSKTTYI 2825
Query: 1856 HV 1857
HV
Sbjct: 2826 HV 2827
Score = 45.8 bits (107), Expect = 0.001
Identities = 48/185 (25%), Positives = 74/185 (40%), Gaps = 34/185 (18%)
Query: 1778 QRSQSVRPGADVTFICTAK-SKSPAYTLVWTRLHNGKLPTRAMD---------FNGILTI 1827
QR Q+V G C K S+SP+ + W L +G + MD +G L I
Sbjct: 486 QRDQTVLEGGPCQLSCNVKASESPS--IFWV-LPDGSILKAPMDDPDSKFSILSSGWLRI 542
Query: 1828 RNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRC 1887
++++ SD+G Y C MD+ + VQ+ T A ++ + PG+ C
Sbjct: 543 KSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTV---TIGKNPGESVTLPC 599
Query: 1888 SATGSPTPTLEWTGGPGGQLPAKAQIH------------GGILRLPAVEPTDQAQYLCRA 1935
+A P L W LP + I+ G L +P V+ +D Y C A
Sbjct: 600 NALAIPEAHLSWI------LPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVA 653
Query: 1936 HSSAG 1940
+ G
Sbjct: 654 VNQQG 658
Score = 45.4 bits (106), Expect = 0.001
Identities = 28/77 (36%), Positives = 35/77 (45%), Gaps = 1/77 (1%)
Query: 411 PPRESIQASRGQTVTFTCVAIGVPTPIINWRL-NWGHIPSHPRVTVTSEGGRGTLIIRDV 469
P E I A G T++ C A G PTP + W L N + S ++ G L I +
Sbjct: 2547 PISEKITAMAGHTISLNCSAAGTPTPSLVWVLPNGTDLQSGQQLQRFYHKADGMLHISGL 2606
Query: 470 KESDQGAYTCEAMNARG 486
D GAY C A NA G
Sbjct: 2607 SSVDAGAYRCVARNAAG 2623
Score = 45.1 bits (105), Expect = 0.002
Identities = 62/245 (25%), Positives = 99/245 (40%), Gaps = 38/245 (15%)
Query: 2504 RVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPH 2563
+V+ S TQ + + T R + S + P ++ G L+C V +
Sbjct: 450 KVLLSYYTQYSQTISTKDTRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESP 509
Query: 2564 TITWYKRGGSL--------PSRHQIVGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLI 2614
+I W GS+ S+ I+ S LRI + P+DSG Y C
Sbjct: 510 SIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYR 569
Query: 2615 VTIQGSGSSHVPSVSPPIRIESSSPTVVE--GQTLDLNCVVARQPQAIITWYKRGGSLPS 2672
V +Q PS P E + T+ + G+++ L C P+A ++W LP+
Sbjct: 570 VLVQS------PSTQP---AEKDTVTIGKNPGESVTLPCNALAIPEAHLSWI-----LPN 615
Query: 2673 RH----QTHGSH--------LRLHQMSVADSGEYVCRANNNIDALEASIVISVS-PSAGS 2719
R + SH L + ++ V+DSG Y C A N A ++ I+V+ +G
Sbjct: 616 RRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGL 675
Query: 2720 PSAPG 2724
PS G
Sbjct: 676 PSKRG 680
Score = 44.3 bits (103), Expect = 0.003
Identities = 29/89 (32%), Positives = 40/89 (44%), Gaps = 10/89 (11%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSE--GGR- 461
PP++ + P I G TV C+A+G+P I W L SH + V + G R
Sbjct: 2732 PPRITSEPTPVIYTRPGNTVKLNCMAMGIPKADITWEL---PDKSHLKAGVQARLYGNRF 2788
Query: 462 ----GTLIIRDVKESDQGAYTCEAMNARG 486
G+L I+ + D G Y C A N G
Sbjct: 2789 LHPQGSLTIQHATQRDAGFYKCMAKNILG 2817
Score = 42.7 bits (99), Expect = 0.008
Identities = 48/194 (24%), Positives = 71/194 (36%), Gaps = 18/194 (9%)
Query: 3216 AEEAELTVEAGHTATLRCSATGSPAPTIHW-----SKLRSPLPWQHR----LEGDTLIIP 3266
A + + TV G L C+ S +P+I W S L++P+ L L I
Sbjct: 484 AVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIK 543
Query: 3267 RVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASV--QAGETVQLQCLAHG 3324
+ DSG Y C A + V+SP + ++ GE+V L C A
Sbjct: 544 SMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALA 603
Query: 3325 TPPLTFQW----SRVGSSLPGRATAR---NELLHFERAAPEDSGRYRCRVTNKVGSAEAF 3377
P W R+ + L + N L + DSG YRC N+ G+
Sbjct: 604 IPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGADHFT 663
Query: 3378 AQLLVQGPPGSLPA 3391
+ V LP+
Sbjct: 664 VGITVTKKGSGLPS 677
Score = 42.7 bits (99), Expect = 0.008
Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 9/76 (11%)
Query: 415 SIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR----GTLIIRDVK 470
++Q G VT C A G P P + W P++ + +SE + GTL+I+ +
Sbjct: 2355 AVQVPYGDVVTVACEAKGEPMPKVTWLS-----PTNKVIPTSSEKYQIYQDGTLLIQKAQ 2409
Query: 471 ESDQGAYTCEAMNARG 486
SD G YTC N+ G
Sbjct: 2410 RSDSGNYTCLVRNSAG 2425
Score = 41.6 bits (96), Expect = 0.018
Identities = 52/214 (24%), Positives = 78/214 (36%), Gaps = 38/214 (17%)
Query: 2343 IRIEPSSS-----QVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL---PVRHQTH------ 2388
+ IEPS + V EG L+C V + W GS+ P+
Sbjct: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
Query: 2389 GSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQV 2448
LR+ P+DSG Y C V ++ + PA T T+
Sbjct: 537 SGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTI-----GKNP 591
Query: 2449 AEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH------------GSRLRLLQVTPA 2496
E TL N L +AH ++W LP R ++ L + +V +
Sbjct: 592 GESVTLPCNALAIPEAH--LSW-----ILPNRRIINDLANTSHVYMLPNGTLSIPKVQVS 644
Query: 2497 DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQ 2530
DSG Y C V G +V +T+ ++ SG S+
Sbjct: 645 DSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSK 678
Score = 41.6 bits (96), Expect = 0.018
Identities = 43/192 (22%), Positives = 77/192 (40%), Gaps = 17/192 (8%)
Query: 1956 PRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL------PPQARSERTDIAT 2009
P V ++T + G +L C S +I W GS+ P ++
Sbjct: 481 PSGAVQRDQTVLEGG-PCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGW 539
Query: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLD 2069
L I ++ +D+G Y C+A + +V+V S S P + ++ + G+++
Sbjct: 540 LRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPSTQ---PAEKDTVTIGKNPGESVT 596
Query: 2070 LNCVVAGSAHAQVTWY----RRGGSLPPHTQVH---GSRLRLPQVSPADSGEYVCRVENG 2122
L C A ++W R L + V+ L +P+V +DSG Y C N
Sbjct: 597 LPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQ 656
Query: 2123 SGPKEASITVSV 2134
G ++ ++V
Sbjct: 657 QGADHFTVGITV 668
Score = 40.8 bits (94), Expect = 0.030
Identities = 49/213 (23%), Positives = 84/213 (39%), Gaps = 18/213 (8%)
Query: 3005 FTVTVPPSEGSSYRLRSPVISIDPPSS-----TVQQGQDASFKCLIHDGAAPISLEW--- 3056
++ T+ + R RS V+ I+P + TV +G C + +P S+ W
Sbjct: 459 YSQTISTKDTRQARGRSWVM-IEPSGAVQRDQTVLEGGPCQLSCNVKASESP-SIFWVLP 516
Query: 3057 -----KTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGP 3111
K + + I +G + I PS+ G Y+C+A + + V + V P
Sbjct: 517 DGSILKAPMDDPDSKFSILSSGWL-RIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSP 575
Query: 3112 PTVSVLPEG-PVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAK-LEQRTYGLMDSHAV 3169
T + + G++VTL C + P + W + L ++ M +
Sbjct: 576 STQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGT 635
Query: 3170 LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIV 3202
L I + SD+G Y C+A N G V + V
Sbjct: 636 LSIPKVQVSDSGYYRCVAVNQQGADHFTVGITV 668
Score = 39.7 bits (91), Expect = 0.067
Identities = 29/85 (34%), Positives = 39/85 (45%), Gaps = 9/85 (10%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHP----RVTVTSEGGR 461
P +T RE A+ G C A G+PTP + W G + P R+TV G
Sbjct: 2446 PNPITTVREI--AAGGSRKLIDCKAEGIPTPRVLWAFPEGVVLPAPYYGNRITVH---GN 2500
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
G+L IR +++SD C A N G
Sbjct: 2501 GSLDIRSLRKSDSVQLVCMARNEGG 2525
Score = 39.3 bits (90), Expect = 0.087
Identities = 48/202 (23%), Positives = 71/202 (35%), Gaps = 53/202 (26%)
Query: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGS-LPARHQTHGSQ--------LRLHLVSPADS 2986
V EG L+C V + W GS L A S+ LR+ + P+DS
Sbjct: 491 VLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDS 550
Query: 2987 GEYVCRA--------------ASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST 3032
G Y C A P + TVT+ + G S L ++I
Sbjct: 551 GLYQCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAH-- 608
Query: 3033 VQQGQDASFKCLIHDGAAPISLEWKTRNQEL------EDNVHISPNGSIITIVGTRPSNH 3086
L W N+ + +V++ PNG++ +I + S+
Sbjct: 609 ---------------------LSWILPNRRIINDLANTSHVYMLPNGTL-SIPKVQVSDS 646
Query: 3087 GTYRCVASNAYGVAQSVVNLSV 3108
G YRCVA N G V ++V
Sbjct: 647 GYYRCVAVNQQGADHFTVGITV 668
Score = 39.3 bits (90), Expect = 0.087
Identities = 34/165 (20%), Positives = 62/165 (37%), Gaps = 16/165 (9%)
Query: 3414 GASVEFHCAVPSDRGTQLRWFKEGGQLPPGHS---------VQDGVLRIQNLDQSCQGTY 3464
G + C V + + W G + + G LRI++++ S G Y
Sbjct: 494 GGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSDSGLY 553
Query: 3465 ICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSK 3524
C A + ++++Q+ + T G +V C AL P+ ++W
Sbjct: 554 QCIAQVRDEMDRMVYRVLVQSPSTQPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWIL 613
Query: 3525 VGGHLRPGIVQS-------GGVVRIAHVELADAGQYRCTATNAAG 3562
+ + + G + I V+++D+G YRC A N G
Sbjct: 614 PNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQG 658
Score = 38.9 bits (89), Expect = 0.11
Identities = 50/207 (24%), Positives = 80/207 (38%), Gaps = 31/207 (14%)
Query: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGSL--------PSRHQTHGSH-LRLHQMSVAD 2690
TV+EG L+C V I W GS+ S+ S LR+ M +D
Sbjct: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
Query: 2691 SGEYVCRAN--NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNC 2748
SG Y C A + +D + +++ SPS + P ++ + GE++ L C
Sbjct: 550 SGLYQCIAQVRDEMDRMVYRVLVQ------SPS----TQPAEKDTVTIGKNPGESVTLPC 599
Query: 2749 VVPGQAHAQVTWHKRGGSL------PSH-HQTRGSRLRLHHVSPADSGEYVCRVMGSSGP 2801
A ++W + SH + L + V +DSG Y C + G
Sbjct: 600 NALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
Query: 2802 LEASVLVTIEASGSSAVHVPAPGGAPP 2828
+V +T+ GS +P+ G P
Sbjct: 660 DHFTVGITVTKKGSG---LPSKRGRRP 683
Score = 38.1 bits (87), Expect = 0.19
Identities = 48/222 (21%), Positives = 79/222 (35%), Gaps = 46/222 (20%)
Query: 2422 VTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSL---- 2477
V IEP+G+V V EG L+C V + W GS+
Sbjct: 477 VMIEPSGAV------------QRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAP 524
Query: 2478 ----PARHQVHGSR-LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGV 2532
++ + S LR+ + P+DSG Y C V +Q +
Sbjct: 525 MDDPDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLVQSPST------- 577
Query: 2533 AYPVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSR------------HQI 2580
P ++ + G ++ L C + ++W LP+R + +
Sbjct: 578 -QPAEKDTVTIGKNPGESVTLPCNALAIPEAHLSWI-----LPNRRIINDLANTSHVYML 631
Query: 2581 VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGS 2622
L IP+V +DSG Y C N G+ ++ +T+ GS
Sbjct: 632 PNGTLSIPKVQVSDSGYYRCVAVNQQGADHFTVGITVTKKGS 673
Score = 38.1 bits (87), Expect = 0.19
Identities = 26/88 (29%), Positives = 36/88 (40%), Gaps = 8/88 (9%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG--- 460
+PP + E+I G ++ C A P P + W L G + R + G
Sbjct: 2045 LPPVIHQEKLENISLPPGLSIHIHCTAKAAPLPSVRWVLGDG---TQIRPSQFLHGNLFV 2101
Query: 461 --RGTLIIRDVKESDQGAYTCEAMNARG 486
GTL IR++ D G Y C A N G
Sbjct: 2102 FPNGTLYIRNLAPKDSGRYECVAANLVG 2129
Score = 37.4 bits (85), Expect = 0.33
Identities = 25/82 (30%), Positives = 37/82 (45%), Gaps = 19/82 (23%)
Query: 415 SIQASRGQTVTFTCVAIGVPTPIINWRL----------NWGHIPSHPRVTVTSEGGRGTL 464
+I + G++VT C A+ +P ++W L N H+ P GTL
Sbjct: 586 TIGKNPGESVTLPCNALAIPEAHLSWILPNRRIINDLANTSHVYMLPN---------GTL 636
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
I V+ SD G Y C A+N +G
Sbjct: 637 SIPKVQVSDSGYYRCVAVNQQG 658
Score = 37.0 bits (84), Expect = 0.43
Identities = 46/189 (24%), Positives = 67/189 (35%), Gaps = 24/189 (12%)
Query: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL------PPHTQ---VHGSRLRLPQVSPAD 2111
+V EG L+C V S + W GS+ P ++ + LR+ + P+D
Sbjct: 490 TVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILSSGWLRIKSMEPSD 549
Query: 2112 SGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDL 2171
SG Y C + V V PS P T I P E TL
Sbjct: 550 SGLYQCIAQVRDEMDRMVYRVLV-----QSPSTQPAEKDTVTIGKNPG-----ESVTLPC 599
Query: 2172 NCVVPGQAHAQVTWHKRGGSLPARHQTH-----GSLLRLHQVTPADSGEYVCHVVGTSGP 2226
N + +AH R + +H L + +V +DSG Y C V G
Sbjct: 600 NALAIPEAHLSWILPNRRIINDLANTSHVYMLPNGTLSIPKVQVSDSGYYRCVAVNQQGA 659
Query: 2227 LEASVLVTI 2235
+V +T+
Sbjct: 660 DHFTVGITV 668
Score = 36.6 bits (83), Expect = 0.56
Identities = 24/74 (32%), Positives = 33/74 (44%), Gaps = 8/74 (10%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG--------GRGTLIIRDVKES 472
G + CVA G+P P I+W L G + + + S G GTL +V
Sbjct: 2258 GGDLKVDCVATGLPNPEISWSLPDGSLVNSFMQSDDSGGRTKRYVVFNNGTLYFNEVGMR 2317
Query: 473 DQGAYTCEAMNARG 486
++G YTC A N G
Sbjct: 2318 EEGDYTCFAENQVG 2331
Score = 36.2 bits (82), Expect = 0.74
Identities = 27/82 (32%), Positives = 36/82 (43%), Gaps = 9/82 (10%)
Query: 410 TPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPS-----HPRVTVTSEGGRGTL 464
T PR + G T+ C A G P P I WRL + R+ V + G TL
Sbjct: 2151 TSPRRT-DVRYGGTLKLDCSASGDPWPRILWRLPSKRMIDALFSFDSRIKVFANG---TL 2206
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
+++ V + D G Y C A N G
Sbjct: 2207 VVKSVTDKDAGDYLCVARNKVG 2228
Score = 35.0 bits (79), Expect = 1.6
Identities = 26/93 (27%), Positives = 38/93 (40%), Gaps = 9/93 (9%)
Query: 3563 TTQSHVLLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSL------P 3616
T Q+ V P ++ ++ V G C +P I W DGS+
Sbjct: 468 TRQARGRSWVMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDD 527
Query: 3617 PDSR---LENNMLMLPSVRPQDAGTYVCTATNR 3646
PDS+ L + L + S+ P D+G Y C A R
Sbjct: 528 PDSKFSILSSGWLRIKSMEPSDSGLYQCIAQVR 560
Score = 34.7 bits (78), Expect = 2.1
Identities = 54/223 (24%), Positives = 76/223 (34%), Gaps = 45/223 (20%)
Query: 2829 IRIEPSSS-----RVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQ---------VH 2874
+ IEPS + V EG L C V + W G++ +
Sbjct: 477 VMIEPSGAVQRDQTVLEGGPCQLSCNVKASESPSIFWVLPDGSILKAPMDDPDSKFSILS 536
Query: 2875 GPLLRLNQVSPADSGEYSC--QVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEAS 2932
LR+ + P+DSG Y C QV + VLV SP QP +
Sbjct: 537 SGWLRIKSMEPSDSGLYQCIAQVRDEMDRMVYRVLV----QSPS-------TQPAEKDTV 585
Query: 2933 SSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGSLPAR------------HQTHGSQLRLHL 2980
+ G+++ L C A ++W LP R + L +
Sbjct: 586 TIGKNPGESVTLPCNALAIPEAHLSWI-----LPNRRIINDLANTSHVYMLPNGTLSIPK 640
Query: 2981 VSPADSGEYVCRAASGPGPEQ-EASFTVTVPPSEGSSYRLRSP 3022
V +DSG Y C A + G + TVT S S R R P
Sbjct: 641 VQVSDSGYYRCVAVNQQGADHFTVGITVTKKGSGLPSKRGRRP 683
>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
Length = 2623
Score = 198 bits (504), Expect = 9e-50
Identities = 247/1008 (24%), Positives = 378/1008 (37%), Gaps = 148/1008 (14%)
Query: 2746 LNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSR--------LRLHHVSPADSGEYVCRVMG 2797
L C G + W + L + + SR L + V D G+Y+C
Sbjct: 1668 LPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSIQRVEIQDRGQYLCSASN 1727
Query: 2798 SSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVA--EGQTLDLKCVVPGQAH 2855
G V +++ + PP +E + + G T++LKC G+
Sbjct: 1728 LFGTDHLHVTLSVVSY-------------PPRILERRTKEITVHSGSTVELKCRAEGRPS 1774
Query: 2856 AQVTW---------HKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASV 2906
VTW G+ A V G L+ L+ +S D G Y C + G + S+
Sbjct: 1775 PTVTWILANQTVVSESSQGSRQAVVTVDGTLV-LHNLSIYDRGFYKCVASNPGG--QDSL 1831
Query: 2907 LVTIEPSSPGPIPAPGLAQPIYIEASSSHV--TEGQTLDLNCVVPGQAHAQVTWYKRGGS 2964
LV I+ I AP P+ +E + T G++L L C G V W G+
Sbjct: 1832 LVKIQV-----IAAP----PVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGT 1882
Query: 2965 LPARHQTHGSQLRLHL--------VSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSS 3016
Q S+L L ++ +D G Y C A S G E+ V + E
Sbjct: 1883 EVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRV---VMLTMEE--- 1936
Query: 3017 YRLRSPVISIDPPSST-VQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN-------VH 3068
R+ SP I T V G C P + W+ ++ + D +H
Sbjct: 1937 -RVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKP-QIMWRLPSKAVVDQQHRVGSWIH 1994
Query: 3069 ISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVH-GPPTVSVLPEGPVWVKVG 3127
+ PNGS+ I + G Y CVA N G ++++S+ P + V G
Sbjct: 1995 VYPNGSLF-IGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKPAKIDHKQYFRKQVLHG 2053
Query: 3128 KAVTLECVSAGEPRSSARWTRISST---------PAKLEQRTYGLMDSHAVLQISSAKPS 3178
K ++C ++G P W+ T + R Y L ++ L + +
Sbjct: 2054 KDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNN-GTLYFNKVGVA 2112
Query: 3179 DAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV-QAEEAELTVEAGHTATLRCSATG 3237
+ G Y C AQN LG + +V + V T A P++ Q+ + ++AG TA L C TG
Sbjct: 2113 EEGDYTCYAQNTLGKDEMKVHLTVITAA-----PRIRQSNKTNKRIKAGDTAVLDCEVTG 2167
Query: 3238 SPAPTIHWSKLRSPL------PWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATI 3291
P P I W + + + G +L I +V DSG+Y+C A +P+G
Sbjct: 2168 DPKPKIFWLLPSNDMISFSIDRYTFHANG-SLTINKVKLLDSGEYVCVARNPSGDDTKMY 2226
Query: 3292 ILHVESPP------YATTVPEHASVQAGETVQLQCLAHGTPPLTFQW---SRVGSSLP-- 3340
L V S P Y A+ C A GTP W + + P
Sbjct: 2227 KLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYY 2286
Query: 3341 -GRATA-RNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGS 3398
R T +N L DS + C N+ G + QL V L P
Sbjct: 2287 GSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEV------LEMLRRPTFR 2340
Query: 3399 TP-TVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW-------FKEGGQLPPGHSVQDGV 3450
P ++ QL G S +C+V + ++ W F G Q +G
Sbjct: 2341 NPFNEKIVAQL-----GKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGS 2395
Query: 3451 LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFEC 3510
I + G Y C A G + L I P +L +V+ + G ++ C
Sbjct: 2396 FIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGIS-GESLSLHC 2454
Query: 3511 LALGDPKPQVTWSKVGGHL--RPGI-----VQSGGVVRIAHVELADAGQYRCTATNAAGT 3563
++ G PKP + W+ G++ RP I + G + I D G Y C A N+ G
Sbjct: 2455 VSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGH 2514
Query: 3564 TQSHVLLLVQALPQISM---PQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR 3620
T V +++ A P P+ + G+A C+A G P P+I+W D SL +
Sbjct: 2515 TLITVPVMIVAYPPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTAS 2574
Query: 3621 LE----------NNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV 3658
E L++ + + D+G Y CTA N G A ++QV
Sbjct: 2575 KERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 182 bits (463), Expect = 5e-45
Identities = 235/1030 (22%), Positives = 393/1030 (38%), Gaps = 157/1030 (15%)
Query: 1674 QAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSG--TQQRHQGSE- 1730
+ P +V A +P L C+ G+P +W+R VPSG +R Q S
Sbjct: 1646 EKPRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTR-----VPSGLDLSKRKQNSRV 1700
Query: 1731 -------LHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSV 1783
L V+ D G Y+C+ NL ++ L V P + + + +V
Sbjct: 1701 QVLPNGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPR---ILERRTKEITV 1757
Query: 1784 RPGADVTFICTAKSKSPAYTLVW-----TRLHNGKLPTR--AMDFNGILTIRNVQLSDAG 1836
G+ V C A+ + P+ T+ W T + +R + +G L + N+ + D G
Sbjct: 1758 HSGSTVELKCRAEGR-PSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
Query: 1837 TYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQP-GQLAEFRCSATGSPTP 1895
Y C SN D +L V+ + PV+ Q+ V G+ + C+A G+P P
Sbjct: 1817 FYKCVASNPGGQD----SLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQP 1872
Query: 1896 TLEWTGGPGGQLPAKA-------QIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVL 1948
++ W G ++ G L + + +D+ Y C A SS G + +L
Sbjct: 1873 SVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVML 1932
Query: 1949 HVHGG-GGPRVQ-VSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTD 2006
+ PR++ S +RT+V+ G + L C A G P I WR ++ Q +
Sbjct: 1933 TMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSW 1992
Query: 2007 I-----ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSS-- 2059
I +L I ++T D+G YLCVA + G ++L P KI+
Sbjct: 1993 IHVYPNGSLFIGSVTEKDSGVYLCVARNKMG------DDLILMHVSLRLKPAKIDHKQYF 2046
Query: 2060 -PSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL--------------PPHTQVHGSRLRL 2104
V G+ ++C +GS +++W G++ +T + L
Sbjct: 2047 RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106
Query: 2105 PQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVA 2164
+V A+ G+Y C +N G E + ++V + + R + ++ +
Sbjct: 2107 NKVGVAEEGDYTCYAQNTLGKDEMKVHLTV------------ITAAPRIRQSNKTNKRIK 2154
Query: 2165 EGQTLDLNCVVPGQAHAQVTWHKRGGSLPA----RHQTHGS-LLRLHQVTPADSGEYVCH 2219
G T L+C V G ++ W + + R+ H + L +++V DSGEYVC
Sbjct: 2155 AGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCV 2214
Query: 2220 VVGTSGPLEASVLVTIEASVIPGPIPPVRIESS--SSTVAEGQTLDLSCVVAGQAHAQVT 2277
SG + + + ++ P I + + +T C G +V
Sbjct: 2215 ARNPSG--DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVM 2272
Query: 2278 WYKRG---------GSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGT 2328
W GS H + L I +D+ ++C A N S+ V
Sbjct: 2273 WIMPDNIFLTAPYYGSRITVH--KNGTLEIRNVRLSDSADFICVARNEGGESVLV----- 2325
Query: 2329 QGANLAYPAGSTQPIRIEPSSSQVAE--GQTLDLNCVVPGQSHAQVTWHKRGGSL----P 2382
L +P P + ++ G++ LNC V G ++ W G+ P
Sbjct: 2326 --VQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGP 2383
Query: 2383 VRHQ----THGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPT 2438
+Q ++GS + + + + D+G+Y C +E V++ I G P +
Sbjct: 2384 QSYQYLIASNGSFI-ISKTTREDAGKYRCAARNKVGYIEKLVILEI---GQKPVILTYAP 2439
Query: 2439 VRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVHG-------SRLRLL 2491
++ S G++L L+C+ G + W G + R Q++G L +
Sbjct: 2440 GTVKGIS-----GESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIK 2494
Query: 2492 QVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIES---SSASLANG 2548
+ T D G Y+C+ S G +V V I VAYP RI + S G
Sbjct: 2495 EATAYDRGNYICKAQNSVGHTLITVPVMI-----------VAYPPRITNRPPRSIVTRTG 2543
Query: 2549 HTLDLNCLVASQAPHTITWYKRGGSL---PSRHQIVGSR-------LRIPQVTPADSGEY 2598
L+C+ ITW SL S+ + GS L I +DSG Y
Sbjct: 2544 AAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIY 2603
Query: 2599 VCHVSNGAGS 2608
C N GS
Sbjct: 2604 KCTAKNPLGS 2613
Score = 173 bits (438), Expect = 4e-42
Identities = 240/983 (24%), Positives = 376/983 (38%), Gaps = 147/983 (14%)
Query: 2392 LRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEG 2451
L + + D G+Y+C S++ + VT+ P + T I V G
Sbjct: 1708 LSIQRVEIQDRGQYLCSA--SNLFGTDHLHVTLSVVSYPPRILERRTKEIT-----VHSG 1760
Query: 2452 QTLDLNCLVAGQAHAQVTW---------HKRGGSLPARHQVHGSRLRLLQVTPADSGEYV 2502
T++L C G+ VTW GS A V G+ L L ++ D G Y
Sbjct: 1761 STVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGT-LVLHNLSIYDRGFYK 1819
Query: 2503 CRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLAN--GHTLDLNCLVASQ 2560
C V + G Q+ S+LV IQ A PV +E + G +L L C
Sbjct: 1820 C-VASNPGGQD-SLLVKIQVI--------AAPPVILEQRRQVIVGTWGESLKLPCTAKGT 1869
Query: 2561 APHTITWYKRGGSLPSRHQIVGSRL--------RIPQVTPADSGEYVCHVSNGAGSRETS 2612
++ W G+ Q S+L I + +D G Y C ++ GS
Sbjct: 1870 PQPSVYWVLSDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRV 1929
Query: 2613 LIVTIQGSGSSHVPSVSPPIRIESSSPTVVE-GQTLDLNCVVARQPQAIITWYKRGGSLP 2671
+++T++ +S P I S T V G L LNC +P+ I W ++
Sbjct: 1930 VMLTMEERVTS------PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVV 1983
Query: 2672 SRHQTHGSHLRLH--------QMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAP 2723
+ GS + ++ ++ DSG Y+C A N + + I++ VS
Sbjct: 1984 DQQHRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMG--DDLILMHVSLRL------ 2035
Query: 2724 GSSMPIRIESSS---SHVAEGETLDLNCVVPGQAHAQVTWHKRGGSL--------PSHHQ 2772
P +I+ V G+ ++C G +++W G++ S H+
Sbjct: 2036 ---KPAKIDHKQYFRKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHR 2092
Query: 2773 TR------GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGA 2826
TR L + V A+ G+Y C + G E V +T+ + A
Sbjct: 2093 TRRYTLFNNGTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITA------------A 2140
Query: 2827 PPIR-IEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPA----RHQVHGP-LLRL 2880
P IR ++ R+ G T L C V G ++ W ++ + R+ H L +
Sbjct: 2141 PRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTI 2200
Query: 2881 NQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQ 2940
N+V DSGEY C SG + + + ++ S P+ I+A++ ++
Sbjct: 2201 NKVKLLDSGEYVCVARNPSG--DDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKH 2258
Query: 2941 TLDLNCVVPGQAHAQVTWYKRGGS-LPARHQTHGSQLRLHL--------VSPADSGEYVC 2991
+C G +V W L A + +GS++ +H V +DS +++C
Sbjct: 2259 ---FDCRAEGTPSPEVMWIMPDNIFLTAPY--YGSRITVHKNGTLEIRNVRLSDSADFIC 2313
Query: 2992 RAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQ-GQDASFKCLIHDGAA 3050
A + G E+ V + E LR P V Q G+ + C + DG
Sbjct: 2314 VARNEGG---ESVLVVQLEVLE----MLRRPTFRNPFNEKIVAQLGKSTALNCSV-DGNP 2365
Query: 3051 PISLEWKTRNQELEDN------VHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVV 3104
P + W N N I+ NGS I TR + G YRC A N G + +V
Sbjct: 2366 PPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTR-EDAGKYRCAARNKVGYIEKLV 2424
Query: 3105 NLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ-RTYGL 3163
L + P + G V G++++L CVS G P+ + +WT S Q +
Sbjct: 2425 ILEIGQKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYI 2484
Query: 3164 MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTV 3223
+ + L I A D G Y+C AQN++G V V++ +A +
Sbjct: 2485 LHDNGTLVIKEATAYDRGNYICKAQNSVGHTLITVPVMI----VAYPPRITNRPPRSIVT 2540
Query: 3224 EAGHTATLRCSATGSPAPTIHW-----------SKLRSPLPWQHRLEGDTLIIPRVAQQD 3272
G L C A G P P I W SK R+ Q L+G TL+I D
Sbjct: 2541 RTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQG-TLVIQNPQTSD 2599
Query: 3273 SGQYICNATSPAGHAEATIILHV 3295
SG Y C A +P G A + V
Sbjct: 2600 SGIYKCTAKNPLGSDYAATYIQV 2622
Score = 160 bits (406), Expect = 2e-38
Identities = 197/859 (22%), Positives = 318/859 (37%), Gaps = 111/859 (12%)
Query: 2878 LRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVT 2937
L + +V D G+Y C + GT V +++ S P P +E + +T
Sbjct: 1708 LSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVV-SYP----------PRILERRTKEIT 1756
Query: 2938 --EGQTLDLNCVVPGQAHAQVTWYKRGGSLPARHQTHGSQ--------LRLHLVSPADSG 2987
G T++L C G+ VTW ++ + Q L LH +S D G
Sbjct: 1757 VHSGSTVELKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRG 1816
Query: 2988 EYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVI------SIDPPSSTVQQGQDASF 3041
Y C AS PG + + V + R VI S+ P T + S
Sbjct: 1817 FYKC-VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPC-TAKGTPQPSV 1874
Query: 3042 KCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQ 3101
++ DG L++ + + NG++ I S+ GTY C+A+++ G +
Sbjct: 1875 YWVLSDGTEVKPLQFTN------SKLFLFSNGTLY-IRNLASSDRGTYECIATSSTGSER 1927
Query: 3102 SVVNLSVHG---PPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQ 3158
VV L++ P + + V G + L C + GEP+ W R+ S +Q
Sbjct: 1928 RVVMLTMEERVTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMW-RLPSKAVVDQQ 1986
Query: 3159 RTYGL---MDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQ 3215
G + + L I S D+G Y+C+A+N +G +++ A
Sbjct: 1987 HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDL----ILMHVSLRLKPAKIDH 2042
Query: 3216 AEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEGD-------------- 3261
+ V G + C A+GSP P I WS L + ++ D
Sbjct: 2043 KQYFRKQVLHGKDFQVDCKASGSPVPEISWS-LPDGTMINNAMQADDSGHRTRRYTLFNN 2101
Query: 3262 -TLIIPRVAQQDSGQYICNATSPAGHAEATIILHV--ESPPYATTVPEHASVQAGETVQL 3318
TL +V + G Y C A + G E + L V +P + + ++AG+T L
Sbjct: 2102 GTLYFNKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAPRIRQSNKTNKRIKAGDTAVL 2161
Query: 3319 QCLAHGTPPLTFQW-----SRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGS 3373
C G P W + S+ N L + DSG Y C N G
Sbjct: 2162 DCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD 2221
Query: 3374 AEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW 3433
+L V P P + + ++ T +K F C ++ W
Sbjct: 2222 DTKMYKLDVVSKP---PLINGLYTNRTVIKATAVRHSKK-----HFDCRAEGTPSPEVMW 2273
Query: 3434 FKEG---------GQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQL-VI 3483
G H ++G L I+N+ S +IC A G++ QL V+
Sbjct: 2274 IMPDNIFLTAPYYGSRITVH--KNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVL 2331
Query: 3484 QALPSVLINIRTSVQTVV-VGHAVEFECLALGDPKPQVTWSKVGGHLRPG-------IVQ 3535
+ L + + V +G + C G+P P++ W G ++
Sbjct: 2332 EMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIA 2391
Query: 3536 SGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQI--SMPQEVRVPAGSAAV 3593
S G I+ DAG+YRC A N G + V+L + P I P V+ +G +
Sbjct: 2392 SNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEIGQKPVILTYAPGTVKGISGESLS 2451
Query: 3594 FPCIASGYPTPDISWSKLDGSLPPDSRL-------ENNMLMLPSVRPQDAGTYVCTATNR 3646
C++ G P P+I W+ G + ++ +N L++ D G Y+C A N
Sbjct: 2452 LHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNS 2511
Query: 3647 QGKVKAFAHLQVPERVVPY 3665
G + VP +V Y
Sbjct: 2512 VGHTL----ITVPVMIVAY 2526
Score = 136 bits (342), Expect = 5e-31
Identities = 134/502 (26%), Positives = 198/502 (39%), Gaps = 73/502 (14%)
Query: 3214 VQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLPWQHR--------LEGDTLII 3265
V + A T+ A A L C A G+P PTIHW+++ S L R L TL I
Sbjct: 1651 VGGKAASFTIPANSDAFLPCEAVGNPLPTIHWTRVPSGLDLSKRKQNSRVQVLPNGTLSI 1710
Query: 3266 PRVAQQDSGQYICNATSPAG--HAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAH 3323
RV QD GQY+C+A++ G H T+ + P + +V +G TV+L+C A
Sbjct: 1711 QRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVELKCRAE 1770
Query: 3324 GTPPLTFQWSRVGSSLPGRATARNE--------LLHFERAAPEDSGRYRCRVTNKVGSAE 3375
G P T W ++ ++ + L + D G Y+C +N G
Sbjct: 1771 GRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASNPGGQDS 1830
Query: 3376 AFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRW-F 3434
++ V P + ++ Q+ + G S++ C + W
Sbjct: 1831 LLVKIQVIAAPPVI------------LEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVL 1878
Query: 3435 KEGGQLPPGHSV-------QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI-QAL 3486
+G ++ P +G L I+NL S +GTY C A G + L + + +
Sbjct: 1879 SDGTEVKPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERV 1938
Query: 3487 PSVLINIRTSVQTVV-VGHAVEFECLALGDPKPQVTW-----------SKVGGHLRPGIV 3534
S I + +T V G + C A G+PKPQ+ W +VG + V
Sbjct: 1939 TSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQHRVGSWIH---V 1995
Query: 3535 QSGGVVRIAHVELADAGQYRCTATNAAG--TTQSHVLLLVQALPQISMPQEVR--VPAGS 3590
G + I V D+G Y C A N G HV L ++ +I Q R V G
Sbjct: 1996 YPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLKP-AKIDHKQYFRKQVLHGK 2054
Query: 3591 AAVFPCIASGYPTPDISWSKLDGSLPPDSR--------------LENNMLMLPSVRPQDA 3636
C ASG P P+ISWS DG++ ++ N L V +
Sbjct: 2055 DFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYFNKVGVAEE 2114
Query: 3637 GTYVCTATNRQGKVKAFAHLQV 3658
G Y C A N GK + HL V
Sbjct: 2115 GDYTCYAQNTLGKDEMKVHLTV 2136
Score = 120 bits (301), Expect = 3e-26
Identities = 136/597 (22%), Positives = 217/597 (36%), Gaps = 67/597 (11%)
Query: 1685 RSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQG-----------SELHF 1733
R V G + C+ SGSP WS DG + + Q G L+F
Sbjct: 2047 RKQVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNAMQADDSGHRTRRYTLFNNGTLYF 2106
Query: 1734 PSVQPSDAGVYICTCRNLHQSNTSRAEL-LVTEAPSKPITVTVEEQRSQSVRPGADVTFI 1792
V ++ G Y C +N + + L ++T AP + + ++ ++ G
Sbjct: 2107 NKVGVAEEGDYTCYAQNTLGKDEMKVHLTVITAAP----RIRQSNKTNKRIKAGDTAVLD 2162
Query: 1793 CTAKSKSPAYTLVWTRLHNG----KLPTRAMDFNGILTIRNVQLSDAGTYVCTGSNMFAM 1848
C + P + W N + NG LTI V+L D+G YVC N
Sbjct: 2163 CEV-TGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLTINKVKLLDSGEYVCVARNPSGD 2221
Query: 1849 DQGTATLHVQASGTLSAPVVSIHPP-QLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQL 1907
D L V + L + + + T F C A G+P+P + W L
Sbjct: 2222 DTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFL 2281
Query: 1908 PA-----KAQIH-GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVS 1961
A + +H G L + V +D A ++C A + G+ V L V +
Sbjct: 2282 TAPYYGSRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRPTFRN 2341
Query: 1962 P--ERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL----PPQARSERTDIATLLIPAI 2015
P E+ G++ L C G P I W G+ P + + +I
Sbjct: 2342 PFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSFIISKT 2401
Query: 2016 TTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVA 2075
T DAG Y C A + G I+ +V+ P + + G++L L+CV
Sbjct: 2402 TREDAGKYRCAARNKVG----YIEKLVILEIGQKPVILTYAPGTVKGISGESLSLHCVSD 2457
Query: 2076 GSAHAQVTWYRRGGSLPPHTQVHG-------SRLRLPQVSPADSGEYVCRVENGSGPKEA 2128
G + W G + Q++G L + + + D G Y+C+ +N G
Sbjct: 2458 GIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTLI 2517
Query: 2129 SITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKR 2188
++ V ++ +Y P R P S G L+CV G ++TW
Sbjct: 2518 TVPVMIV-------AYPP-----RITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMP 2565
Query: 2189 GGSL---PARHQTHGS-------LLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTI 2235
SL ++ +THGS L + +DSG Y C G A+ + +
Sbjct: 2566 DHSLLSTASKERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQV 2622
Score = 110 bits (274), Expect = 4e-23
Identities = 120/499 (24%), Positives = 194/499 (38%), Gaps = 53/499 (10%)
Query: 1675 APLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQR--HQGSELH 1732
AP + + + + G + L C+V+G P +W + + H L
Sbjct: 2140 APRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLLPSNDMISFSIDRYTFHANGSLT 2199
Query: 1733 FPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQR----SQSVRPGAD 1788
V+ D+G Y+C RN +T +L V P P+ + R + +VR +
Sbjct: 2200 INKVKLLDSGEYVCVARNPSGDDTKMYKLDVVSKP--PLINGLYTNRTVIKATAVR-HSK 2256
Query: 1789 VTFICTAKSKSPAYTLVWTRLHNGKLPTR------AMDFNGILTIRNVQLSDAGTYVCTG 1842
F C A+ +P+ ++W N L + NG L IRNV+LSD+ ++C
Sbjct: 2257 KHFDCRAEG-TPSPEVMWIMPDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFICVA 2315
Query: 1843 SNMFAMDQGTATLHVQASGTLSAPVVSIHPP---QLTVQPGQLAEFRCSATGSPTPTLEW 1899
N + G + L VQ + P ++ Q G+ CS G+P P + W
Sbjct: 2316 RN----EGGESVLVVQLEVLEMLRRPTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIW 2371
Query: 1900 TGGPGGQLPAKAQIH------GGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGG 1953
G + Q + G + D +Y C A + G +L + G
Sbjct: 2372 ILPNGTRFSNGPQSYQYLIASNGSFIISKTTREDAGKYRCAARNKVGYIEKLVILEI-GQ 2430
Query: 1954 GGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGSL--PPQARSERT--DIAT 2009
+ +P + +G ++ L+C + G+P I W G + PQ + D T
Sbjct: 2431 KPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGT 2490
Query: 2010 LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTE-GQTL 2068
L+I T D G Y+C A + G + V+++ A PP + VT G
Sbjct: 2491 LVIKEATAYDRGNYICKAQNSVGHTLITVPVMIV----AYPPRITNRPPRSIVTRTGAAF 2546
Query: 2069 DLNCVVAGSAHAQVTWYRRGGSL---PPHTQVHGSR---------LRLPQVSPADSGEYV 2116
L+CV G ++TW SL + HGS ++ PQ S DSG Y
Sbjct: 2547 QLHCVALGVPKPEITWEMPDHSLLSTASKERTHGSEQLHLQGTLVIQNPQTS--DSGIYK 2604
Query: 2117 CRVENGSGPKEASITVSVL 2135
C +N G A+ + V+
Sbjct: 2605 CTAKNPLGSDYAATYIQVI 2623
Score = 102 bits (253), Expect = 1e-20
Identities = 103/408 (25%), Positives = 162/408 (39%), Gaps = 45/408 (11%)
Query: 1669 LPETNQAPLVVEVHPARSIVPQGG-SHSLR---CQVSGSPPHYFYWSREDG----RPVPS 1720
L ++ PL+ ++ R+++ HS + C+ G+P W D P
Sbjct: 2228 LDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMPDNIFLTAPYYG 2287
Query: 1721 GTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRS 1780
H+ L +V+ SD+ +IC RN + +L V E +P T +
Sbjct: 2288 SRITVHKNGTLEIRNVRLSDSADFICVARNEGGESVLVVQLEVLEMLRRP---TFRNPFN 2344
Query: 1781 QSV--RPGADVTFICTAKSKSPAYTLVW-----TRLHNGKLPTRAM-DFNGILTIRNVQL 1832
+ + + G C+ P ++W TR NG + + NG I
Sbjct: 2345 EKIVAQLGKSTALNCSVDGNPPP-EIIWILPNGTRFSNGPQSYQYLIASNGSFIISKTTR 2403
Query: 1833 SDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQ--PGQLAEFRCSAT 1890
DAG Y C N + L + PV+ + P TV+ G+ C +
Sbjct: 2404 EDAGKYRCAARNKVGYIEKLVILEIGQK-----PVILTYAPG-TVKGISGESLSLHCVSD 2457
Query: 1891 GSPTPTLEWTGGPGGQLPAKAQIHG-------GILRLPAVEPTDQAQYLCRAHSSAGQQV 1943
G P P ++WT P G + + QI+G G L + D+ Y+C+A +S G +
Sbjct: 2458 GIPKPNIKWTM-PSGYVVDRPQINGKYILHDNGTLVIKEATAYDRGNYICKAQNSVGHTL 2516
Query: 1944 ARAVLHVHGGGGPRVQVSPERTQV-HAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARS 2002
+ + PR+ P R+ V G +L+C A GVP ITW SL A
Sbjct: 2517 ITVPVMIVAYP-PRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEMPDHSLLSTASK 2575
Query: 2003 ERTD-------IATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVL 2043
ERT TL+I T+D+G Y C A +P G+ A + V+
Sbjct: 2576 ERTHGSEQLHLQGTLVIQNPQTSDSGIYKCTAKNPLGSDYAATYIQVI 2623
Score = 100 bits (248), Expect = 4e-20
Identities = 70/234 (29%), Positives = 107/234 (45%), Gaps = 19/234 (8%)
Query: 3448 DGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVE 3507
+G L IQ ++ +G Y+C A +G L + + P ++ RT TV G VE
Sbjct: 1705 NGTLSIQRVEIQDRGQYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEITVHSGSTVE 1764
Query: 3508 FECLALGDPKPQVTW--------SKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATN 3559
+C A G P P VTW S+ R +V G + + ++ + D G Y+C A+N
Sbjct: 1765 LKCRAEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDRGFYKCVASN 1824
Query: 3560 AAGTTQSHVLLLVQALPQISMPQEVRVPAGS---AAVFPCIASGYPTPDISWSKLDGS-L 3615
G V + V A P + + Q +V G+ + PC A G P P + W DG+ +
Sbjct: 1825 PGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEV 1884
Query: 3616 PP----DSRL---ENNMLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQVPERV 3662
P +S+L N L + ++ D GTY C AT+ G + L + ERV
Sbjct: 1885 KPLQFTNSKLFLFSNGTLYIRNLASSDRGTYECIATSSTGSERRVVMLTMEERV 1938
Score = 57.8 bits (138), Expect = 2e-07
Identities = 50/202 (24%), Positives = 79/202 (39%), Gaps = 21/202 (10%)
Query: 1876 TVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIH--------GGILRLPAVEPTD 1927
TV G C G PTP ++W G ++ A G L L + D
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
Query: 1928 QAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI 1987
Y C + + + + V Q + V G T+ L C + G+P A+I
Sbjct: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
Query: 1988 TWRKEGGSLPPQARSERTDI--ATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSA 2045
+W G ++ Q+ ++ + TL I +T D G+Y CVA +P+G QV
Sbjct: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIFQV----- 660
Query: 2046 SDASPPPVKIESSSPSVTEGQT 2067
VK++ P +G+T
Sbjct: 661 ------SVKMKGQRPLEHDGET 676
Score = 55.5 bits (132), Expect = 1e-06
Identities = 46/167 (27%), Positives = 66/167 (39%), Gaps = 17/167 (10%)
Query: 3499 TVVVGHAVEFECLALGDPKPQVTWSKVGGH--LRPGIVQSG-------GVVRIAHVELAD 3549
TV+VG V C GDP P V W G P + + G G + + + D
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
Query: 3550 AGQYRCTATN-AAGTTQSHVLLLVQALPQISMPQEVR--VPAGSAAVFPCIASGYPTPDI 3606
G Y C ++N ++ + +V+ L + + V G PC ++G P I
Sbjct: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
Query: 3607 SW-----SKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTATNRQG 3648
SW + L S L N L + V P+D G Y C A N G
Sbjct: 606 SWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 53.1 bits (126), Expect = 6e-06
Identities = 45/170 (26%), Positives = 66/170 (38%), Gaps = 12/170 (7%)
Query: 3124 VKVGKAVTLECVSAGEPRSSARWTRISSTPAK---LEQRTYGLMDSHAVLQISSAKPSDA 3180
V VG V L C G+P W + + + + L+D L++ A D
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 3181 GTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPA 3240
G Y C++ N + V + P Q TV G T L C +TG P
Sbjct: 547 GVYHCISSNYDDADILTYRITV----VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
Query: 3241 PTIHWSKLRSPLPWQHR-----LEGDTLIIPRVAQQDSGQYICNATSPAG 3285
+I W + + +Q L TL I +V +D G Y C A +P+G
Sbjct: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 52.8 bits (125), Expect = 8e-06
Identities = 30/91 (32%), Positives = 42/91 (46%), Gaps = 14/91 (15%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG---- 460
PP++ P SI G CVA+GVP P I W + P H ++ S+
Sbjct: 2527 PPRITNRPPRSIVTRTGAAFQLHCVALGVPKPEITWEM-----PDHSLLSTASKERTHGS 2581
Query: 461 -----RGTLIIRDVKESDQGAYTCEAMNARG 486
+GTL+I++ + SD G Y C A N G
Sbjct: 2582 EQLHLQGTLVIQNPQTSDSGIYKCTAKNPLG 2612
Score = 51.2 bits (121), Expect = 2e-05
Identities = 50/181 (27%), Positives = 71/181 (39%), Gaps = 40/181 (22%)
Query: 3220 ELTVEAGHTATLRCSATGSPAPTIHW-----SKLRSPLPWQHRLEGDTLI-------IPR 3267
E TV G T L C G P P + W SK+R+P + +G LI +
Sbjct: 484 EHTVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSE---DGRILIDKSGKLELQM 540
Query: 3268 VAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPE-----------HASVQAGETV 3316
D+G Y C +++ + +A I+ Y TV E H +V GET+
Sbjct: 541 ADSFDTGVYHCISSN---YDDADIL------TYRITVVEPLVEAYQENGIHHTVFIGETL 591
Query: 3317 QLQCLAHGTPPLTFQWSRVGS-----SLPGRATARNELLHFERAAPEDSGRYRCRVTNKV 3371
L C + G P + W G+ S + N L + P+D G YRC N
Sbjct: 592 DLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPS 651
Query: 3372 G 3372
G
Sbjct: 652 G 652
Score = 49.7 bits (117), Expect = 6e-05
Identities = 23/82 (28%), Positives = 45/82 (54%), Gaps = 1/82 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVT-VTSEGGRGTL 464
P ++T +++ G++++ CV+ G+P P I W + G++ P++ GTL
Sbjct: 2432 PVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQINGKYILHDNGTL 2491
Query: 465 IIRDVKESDQGAYTCEAMNARG 486
+I++ D+G Y C+A N+ G
Sbjct: 2492 VIKEATAYDRGNYICKAQNSVG 2513
Score = 47.0 bits (110), Expect = 4e-04
Identities = 52/184 (28%), Positives = 74/184 (40%), Gaps = 24/184 (13%)
Query: 1967 VHAGRTVRLYCRAAGVPSATITWRKEGGS---LPPQARSERTDI---ATLLIPAITTADA 2020
V G TV L C G P+ + W GS P + R I L + + D
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 2021 GFYLCVATS--PAGTAQARIQVVVLSASDASPPPVKIESSSP---SVTEGQTLDLNCVVA 2075
G Y C++++ A RI VV P V+ + +V G+TLDL C
Sbjct: 547 GVYHCISSNYDDADILTYRITVV--------EPLVEAYQENGIHHTVFIGETLDLPCHST 598
Query: 2076 GSAHAQVTWYRRGGSLPPHTQ-----VHGSRLRLPQVSPADSGEYVCRVENGSGPKEASI 2130
G A ++W G ++ + ++ LR+ QV+P D G Y C N SG
Sbjct: 599 GIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVDFLIF 658
Query: 2131 TVSV 2134
VSV
Sbjct: 659 QVSV 662
Score = 46.2 bits (108), Expect = 7e-04
Identities = 67/314 (21%), Positives = 112/314 (35%), Gaps = 59/314 (18%)
Query: 2738 VAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQT---------RGSRLRLHHVSPADS 2788
V G T+ LNC G V W GS + +L L D+
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 2789 GEYVCRVMGSSGPLEASVLV--------TIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE 2840
G Y C SS +A +L +EA + +H V
Sbjct: 547 GVYHCI---SSNYDDADILTYRITVVEPLVEAYQENGIH----------------HTVFI 587
Query: 2841 GQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQ-----VHGPLLRLNQVSPADSGEYSCQV 2895
G+TLDL C G A ++W G N+ + ++ LR+ QV+P D G Y C
Sbjct: 588 GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVA 647
Query: 2896 TGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASS--SHVTE--GQTLDLNCVVPGQ 2951
SG V+++ P+ G + ++ S+ +H+ E G L + ++ +
Sbjct: 648 ANPSGVDFLIFQVSVKMKGQRPLEHDGETEGSGLDESNPIAHLKEPPGAQLRTSALMEAE 707
Query: 2952 A------------HAQVTWYKRGGSLPARHQTHGSQL--RLHLVSPADSGEYVCRAASGP 2997
+ ++T +RG S R + + + P + +A
Sbjct: 708 VGKHTSSTSKRHNYRELTLQRRGDSTHRRFRENRRHFPPSARRIDPQHWAALLEKAKKNA 767
Query: 2998 GPEQEASFTVTVPP 3011
P++ + TV+ PP
Sbjct: 768 MPDKRENTTVSPPP 781
Score = 46.2 bits (108), Expect = 7e-04
Identities = 54/191 (28%), Positives = 75/191 (39%), Gaps = 31/191 (16%)
Query: 2352 VAEGQTLDLNCVVPGQSHAQVTWHKRGGS---LPVRHQTHGSL------LRLYQASPADS 2402
V G T+ LNC G V W GS P + L L L A D+
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 2403 GEYVCRVLGSSVPLEASVLV----TIEP-AGSVPALGVTPTVRIESSSSQVAEGQTLDLN 2457
G Y C SS +A +L +EP + G+ TV I G+TLDL
Sbjct: 547 GVYHCI---SSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI---------GETLDLP 594
Query: 2458 CLVAGQAHAQVTWHKRGGSLPARHQ-----VHGSRLRLLQVTPADSGEYVCRVVGSSGTQ 2512
C G A ++W G ++ + ++ LR+LQVTP D G Y C SG
Sbjct: 595 CHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
Query: 2513 EASVLVTIQQR 2523
V+++ +
Sbjct: 655 FLIFQVSVKMK 665
Score = 46.2 bits (108), Expect = 7e-04
Identities = 52/178 (29%), Positives = 72/178 (40%), Gaps = 30/178 (16%)
Query: 2448 VAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPARHQVH---------GSRLRLLQVTPADS 2498
V G T+ LNC G V W GS V +L L D+
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 2499 GEYVCRVVGSSGTQEASVL---VTIQQRLSGSHSQ-GVAYPVRIESSSASLANGHTLDLN 2554
G Y C SS +A +L +T+ + L ++ + G+ + V I G TLDL
Sbjct: 547 GVYHCI---SSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI---------GETLDLP 594
Query: 2555 CLVASQAPHTITWYKRGGSL---PSRHQIV--GSRLRIPQVTPADSGEYVCHVSNGAG 2607
C +I+W G ++ SR + V LRI QVTP D G Y C +N +G
Sbjct: 595 CHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 46.2 bits (108), Expect = 7e-04
Identities = 44/167 (26%), Positives = 64/167 (38%), Gaps = 18/167 (10%)
Query: 2163 VAEGQTLDLNCVVPGQAHAQVTWHKRGGS-LPARHQTH--------GSLLRLHQVTPADS 2213
V G T+ LNC G V W GS + A + + L L D+
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 2214 GEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAH 2273
G Y C S + + ++T +V+ + + TV G+TLDL C G
Sbjct: 547 GVYHC----ISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
Query: 2274 AQVTWYKRGG-----SLPARHQVRGSRLYIFQASPADAGQYVCRASN 2315
A ++W G S + + L I Q +P D G Y C A+N
Sbjct: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
Score = 45.8 bits (107), Expect = 0.001
Identities = 45/168 (26%), Positives = 63/168 (37%), Gaps = 23/168 (13%)
Query: 2255 TVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQV---------RGSRLYIFQASPAD 2305
TV G T+ L+C G V W GS V + +L + A D
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
Query: 2306 AGQYVCRASNGMEASI-TVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVV 2364
G Y C +SN +A I T +T + AY V G+TLDL C
Sbjct: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIH--------HTVFIGETLDLPCHS 597
Query: 2365 PGQSHAQVTWHKRGGSLPVRHQ-----THGSLLRLYQASPADSGEYVC 2407
G A ++W G ++ + + LR+ Q +P D G Y C
Sbjct: 598 TGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRC 645
Score = 44.3 bits (103), Expect = 0.003
Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 12/89 (13%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR--- 461
PP+++ + I G TV C A G P+P + W L + V+ +S+G R
Sbjct: 1744 PPRILERRTKEITVHSGSTVELKCRAEGRPSPTVTWIL-----ANQTVVSESSQGSRQAV 1798
Query: 462 ----GTLIIRDVKESDQGAYTCEAMNARG 486
GTL++ ++ D+G Y C A N G
Sbjct: 1799 VTVDGTLVLHNLSIYDRGFYKCVASNPGG 1827
Score = 44.3 bits (103), Expect = 0.003
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 2/84 (2%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTS--EGGRG 462
PP ++ R+ I + G+++ C A G P P + W L+ G + T + G
Sbjct: 1841 PPVILEQRRQVIVGTWGESLKLPCTAKGTPQPSVYWVLSDGTEVKPLQFTNSKLFLFSNG 1900
Query: 463 TLIIRDVKESDQGAYTCEAMNARG 486
TL IR++ SD+G Y C A ++ G
Sbjct: 1901 TLYIRNLASSDRGTYECIATSSTG 1924
Score = 43.5 bits (101), Expect = 0.005
Identities = 46/179 (25%), Positives = 67/179 (37%), Gaps = 26/179 (14%)
Query: 2061 SVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL--PPHTQVHG-------SRLRLPQVSPAD 2111
+V G T+ LNC G V W GS P+ G +L L D
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
Query: 2112 SGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDL 2171
+G Y C N + ++V+ P+ + + I + V G+TLDL
Sbjct: 546 TGVYHCISSNYDDADILTYRITVVE---------PLVEAYQENGIHHT---VFIGETLDL 593
Query: 2172 NCVVPGQAHAQVTWHKRGGSLPARHQT-----HGSLLRLHQVTPADSGEYVCHVVGTSG 2225
C G A ++W G ++ + + LR+ QVTP D G Y C SG
Sbjct: 594 PCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 42.4 bits (98), Expect = 0.010
Identities = 46/177 (25%), Positives = 65/177 (36%), Gaps = 26/177 (14%)
Query: 2640 TVVEGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQT---------HGSHLRLHQMSVAD 2690
TV+ G T+ LNC P + W GS L L D
Sbjct: 486 TVLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFD 545
Query: 2691 SGEYVCRANNNIDA-LEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCV 2749
+G Y C ++N DA + + V P + G + I GETLDL C
Sbjct: 546 TGVYHCISSNYDDADILTYRITVVEPLVEAYQENGIHHTVFI---------GETLDLPCH 596
Query: 2750 VPGQAHAQVTWHKRGGSLPSHHQTRGSR------LRLHHVSPADSGEYVCRVMGSSG 2800
G A ++W G ++ + +R + LR+ V+P D G Y C SG
Sbjct: 597 STGIPDASISWVIPGNNV-LYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSG 652
Score = 39.7 bits (91), Expect = 0.067
Identities = 30/108 (27%), Positives = 45/108 (41%), Gaps = 4/108 (3%)
Query: 3087 GTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVW--VKVGKAVTLECVSAGEPRSSA 3144
G Y C++SN Y A + P V E + V +G+ + L C S G P +S
Sbjct: 547 GVYHCISSN-YDDADILTYRITVVEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPDASI 605
Query: 3145 RWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALG 3192
W + R ++++ L+I P D G Y C+A N G
Sbjct: 606 SWVIPGNNVLYQSSRDKKVLNN-GTLRILQVTPKDQGYYRCVAANPSG 652
Score = 39.7 bits (91), Expect = 0.067
Identities = 27/88 (30%), Positives = 35/88 (39%), Gaps = 12/88 (13%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGG----- 460
P++ ++ + + G + C A G P P I WRL PS V G
Sbjct: 1941 PRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRL-----PSKAVVDQQHRVGSWIHV 1995
Query: 461 --RGTLIIRDVKESDQGAYTCEAMNARG 486
G+L I V E D G Y C A N G
Sbjct: 1996 YPNGSLFIGSVTEKDSGVYLCVARNKMG 2023
Score = 37.4 bits (85), Expect = 0.33
Identities = 25/87 (28%), Positives = 36/87 (41%), Gaps = 10/87 (11%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR---- 461
P++V S C A+G P P I+W +PS ++ + R
Sbjct: 1648 PRIVGGKAASFTIPANSDAFLPCEAVGNPLPTIHWT----RVPSGLDLSKRKQNSRVQVL 1703
Query: 462 --GTLIIRDVKESDQGAYTCEAMNARG 486
GTL I+ V+ D+G Y C A N G
Sbjct: 1704 PNGTLSIQRVEIQDRGQYLCSASNLFG 1730
Score = 37.0 bits (84), Expect = 0.43
Identities = 41/170 (24%), Positives = 59/170 (34%), Gaps = 16/170 (9%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPS------GTQQRHQGSELHFPSVQPSDAGVY 1744
GG+ L C G P + W DG V + G + +L D GVY
Sbjct: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
Query: 1745 ICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQR-SQSVRPGADVTFICTAKSKSPAYT 1803
C N ++ + V E P+ +E +V G + C + P +
Sbjct: 550 HCISSNYDDADILTYRITVVE----PLVEAYQENGIHHTVFIGETLDLPCHSTG-IPDAS 604
Query: 1804 LVWTRLHNGKLPTRAMDF----NGILTIRNVQLSDAGTYVCTGSNMFAMD 1849
+ W N L + D NG L I V D G Y C +N +D
Sbjct: 605 ISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAANPSGVD 654
Score = 37.0 bits (84), Expect = 0.43
Identities = 25/84 (29%), Positives = 31/84 (36%), Gaps = 1/84 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRL-NWGHIPSHPRVTVTSEGGRGTL 464
P P E I A G++ C G P P I W L N + P+ G+
Sbjct: 2337 PTFRNPFNEKIVAQLGKSTALNCSVDGNPPPEIIWILPNGTRFSNGPQSYQYLIASNGSF 2396
Query: 465 IIRDVKESDQGAYTCEAMNARGMV 488
II D G Y C A N G +
Sbjct: 2397 IISKTTREDAGKYRCAARNKVGYI 2420
Score = 36.6 bits (83), Expect = 0.56
Identities = 27/91 (29%), Positives = 42/91 (46%), Gaps = 7/91 (7%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHI---PSHPRVTVTSEGGRGTLIIRDVKESDQGAY 477
G+T+ C + G+P I+W + ++ S + + + GTL I V DQG Y
Sbjct: 588 GETLDLPCHSTGIPDASISWVIPGNNVLYQSSRDKKVLNN----GTLRILQVTPKDQGYY 643
Query: 478 TCEAMNARGMVFGIPDGVLELVPQRGPCPDG 508
C A N G+ F I +++ QR DG
Sbjct: 644 RCVAANPSGVDFLIFQVSVKMKGQRPLEHDG 674
Score = 36.2 bits (82), Expect = 0.74
Identities = 40/167 (23%), Positives = 59/167 (35%), Gaps = 21/167 (12%)
Query: 2548 GHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIV---------GSRLRIPQVTPADSGEY 2598
G T+ LNC + W GS + +L + D+G Y
Sbjct: 490 GGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDTGVY 549
Query: 2599 VCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQ 2658
C SN + + +T+ V + + TV G+TLDL C P
Sbjct: 550 HCISSNYDDADILTYRITV-------VEPLVEAYQENGIHHTVFIGETLDLPCHSTGIPD 602
Query: 2659 AIITWYKRGG-----SLPSRHQTHGSHLRLHQMSVADSGEYVCRANN 2700
A I+W G S + + LR+ Q++ D G Y C A N
Sbjct: 603 ASISWVIPGNNVLYQSSRDKKVLNNGTLRILQVTPKDQGYYRCVAAN 649
Score = 35.8 bits (81), Expect = 0.96
Identities = 24/85 (28%), Positives = 35/85 (41%), Gaps = 9/85 (10%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEG----GR 461
P++ + + + G T C G P P I W L PS+ ++ + +
Sbjct: 2141 PRIRQSNKTNKRIKAGDTAVLDCEVTGDPKPKIFWLL-----PSNDMISFSIDRYTFHAN 2195
Query: 462 GTLIIRDVKESDQGAYTCEAMNARG 486
G+L I VK D G Y C A N G
Sbjct: 2196 GSLTINKVKLLDSGEYVCVARNPSG 2220
Score = 34.3 bits (77), Expect = 2.8
Identities = 46/188 (24%), Positives = 68/188 (36%), Gaps = 27/188 (14%)
Query: 2936 VTEGQTLDLNCVVPGQAHAQVTWYKRGGS-LPARHQTH--------GSQLRLHLVSPADS 2986
V G T+ LNC G V W GS + A + + +L L + D+
Sbjct: 487 VLVGGTVGLNCPGQGDPTPHVDWLLADGSKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 2987 GEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIH 3046
G Y C +S ++ +TV +Y+ TV G+ C H
Sbjct: 547 GVYHC-ISSNYDDADILTYRITVVEPLVEAYQENGI-------HHTVFIGETLDLPC--H 596
Query: 3047 DGAAP-ISLEW-----KTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVA 3100
P S+ W Q D + N + I+ P + G YRCVA+N GV
Sbjct: 597 STGIPDASISWVIPGNNVLYQSSRDKKVL--NNGTLRILQVTPKDQGYYRCVAANPSGVD 654
Query: 3101 QSVVNLSV 3108
+ +SV
Sbjct: 655 FLIFQVSV 662
Score = 33.9 bits (76), Expect = 3.7
Identities = 24/79 (30%), Positives = 33/79 (41%), Gaps = 10/79 (12%)
Query: 417 QASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR---------GTLIIR 467
Q G+ C A G P P I+W L G + ++ + G R GTL
Sbjct: 2049 QVLHGKDFQVDCKASGSPVPEISWSLPDGTMINNA-MQADDSGHRTRRYTLFNNGTLYFN 2107
Query: 468 DVKESDQGAYTCEAMNARG 486
V +++G YTC A N G
Sbjct: 2108 KVGVAEEGDYTCYAQNTLG 2126
Score = 33.9 bits (76), Expect = 3.7
Identities = 23/67 (34%), Positives = 31/67 (46%), Gaps = 11/67 (16%)
Query: 426 FTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR------GTLIIRDVKESDQGAYTC 479
F C A G P+P + W + P + +T G R GTL IR+V+ SD + C
Sbjct: 2259 FDCRAEGTPSPEVMWIM-----PDNIFLTAPYYGSRITVHKNGTLEIRNVRLSDSADFIC 2313
Query: 480 EAMNARG 486
A N G
Sbjct: 2314 VARNEGG 2320
Score = 33.1 bits (74), Expect = 6.2
Identities = 24/69 (34%), Positives = 29/69 (42%), Gaps = 9/69 (13%)
Query: 421 GQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR------GTLIIRDVKESDQ 474
G TV C G PTP ++W L G S R SE GR G L ++ D
Sbjct: 490 GGTVGLNCPGQGDPTPHVDWLLADG---SKVRAPYVSEDGRILIDKSGKLELQMADSFDT 546
Query: 475 GAYTCEAMN 483
G Y C + N
Sbjct: 547 GVYHCISSN 555
>gi|13489095 sialoadhesin precursor [Homo sapiens]
Length = 1709
Score = 185 bits (470), Expect = 8e-46
Identities = 415/1794 (23%), Positives = 636/1794 (35%), Gaps = 327/1794 (18%)
Query: 1652 QCGPGYVGNPSVQG--GQCL--PETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHY 1707
Q G VQG G CL P P VEV + + R VS S
Sbjct: 18 QASWGVSSPQDVQGVKGSCLLIPCIFSFPADVEVPDGITAIWYYDYSGQRQVVSHSADPK 77
Query: 1708 FYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRNLHQSNTSRAE---LLVT 1764
+R GR G + H+ L +QP D+G Y + S + + VT
Sbjct: 78 LVEARFRGRTEFMGNPE-HRVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVT 136
Query: 1765 EAPSKP-ITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLHNGKLPTRAMDFN- 1822
E P P I VE V ++C + L W G+ P R++ FN
Sbjct: 137 EEPRVPTIASPVELLEGTEVDFNCSTPYVCLQEQ----VRLQW----QGQDPARSVTFNS 188
Query: 1823 --------GILTIRNVQLS--DAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHP 1872
G L ++ +S D G + ++ A + + +H+Q + + P
Sbjct: 189 QKFEPTGVGHLETLHMAMSWQDHGRILRCQLSV-ANHRAQSEIHLQVKYAPKGVKILLSP 247
Query: 1873 PQLTVQPGQLAEFRCSATGS--PTPTLEWTGGPGGQLPAKAQIHGGILRLPAVEPTDQAQ 1930
+ PG+L C S +++W G +L K G+L LP +D
Sbjct: 248 SGRNILPGELVTLTCQVNSSYPAVSSIKWL-KDGVRLQTKT----GVLHLPQAAWSDAGV 302
Query: 1931 YLCRAHSSAGQQVARAV-LHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATI-- 1987
Y C+A + G V+ + LH+ VQVSP + +TV L C + +
Sbjct: 303 YTCQAENGVGSLVSPPISLHIFMA---EVQVSP-AGPILENQTVTLVCNTPNEAPSDLRY 358
Query: 1988 TWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSASD 2047
+W K L E TL + T AD GFY C + G+ ++ VV++
Sbjct: 359 SWYKNHVLL------EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVN--- 409
Query: 2048 ASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSL----------PPHTQV 2097
PP + ++ G L+C V A + G L P +
Sbjct: 410 -HPPLTPVLTAFLETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGT 468
Query: 2098 HGS---RLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPI 2154
G RL + + DSGEY C N G +++ H + +P
Sbjct: 469 SGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLD---FHANAARLLISP-------- 517
Query: 2155 RIEPSSSHVAEGQTLDLNC--VVPGQAHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPAD 2212
++ V EGQ + L+C + A+ +W+ G L H+ GS L L + D
Sbjct: 518 -----AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASSTD 569
Query: 2213 SGEYVCHV---VGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVA 2269
+G Y C SGP +VL + P R++ ++ G+ L C V
Sbjct: 570 AGSYHCRARDGHSASGPSSPAVLTVLYPP--RQPTFTTRLDLDAAGAGAGRRGLLLCRVD 627
Query: 2270 GQAHAQVTWYKR-----------------GGSLPARHQVRGS---RLYIFQASPADAGQY 2309
A++ + GG P + R+ I + G Y
Sbjct: 628 SDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLY 687
Query: 2310 VCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ-- 2367
+C ASN + + T Q LA I PS + + EG +L C V +
Sbjct: 688 LCEASNALGNASTSATFNGQATVLA----------IAPSHT-LQEGTEANLTCNVSREAA 736
Query: 2368 -SHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL-GSSVPLEASVLVTIE 2425
S A +W + G + Q + L + D+ Y CR+L + L VL+++
Sbjct: 737 GSPANFSWFRNG---VLWAQGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVL 793
Query: 2426 PAGSVPALGVTPTVRIESSSSQVA------EGQTLDLNCLVAGQ------AHAQVTWHKR 2473
P L + ++ +A + + L L L G+ QV H
Sbjct: 794 YPPDRPKL----SALLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH-- 847
Query: 2474 GGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVA 2533
G A+ + + +L + ++ DSG Y C G+ S+ ++ G+ Q
Sbjct: 848 -GRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR----GAWVQ--- 899
Query: 2534 YPVRIESSSASLANGHTLDLNCLVASQAPH--TITWYKRGGSLPSRHQIVGSRLRIPQVT 2591
S S L G + L+C V + P + WY+ G L + + LR +T
Sbjct: 900 -----VSPSPELQEGQAVVLSCQVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAIT 951
Query: 2592 PADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNC 2651
+G Y C + GS TSL I S HV + + + T G+ L C
Sbjct: 952 LTQAGAYHCQ-AQAPGSATTSLAAPI----SLHVSYAPRHVTLTTLMDT-GPGRLGLLLC 1005
Query: 2652 VVARQPQA---------IITWYKRG-----GSLPSRH---QTHGSHLRLHQMSVADSGEY 2694
V P A ++ +G GS P H + L +H + D G Y
Sbjct: 1006 RVDSDPPAQLRLLHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVY 1065
Query: 2695 VCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQA 2754
+C A+N + AS + + PG++ V EG+ ++L C+V
Sbjct: 1066 ICEASNTLGQASASADFD-AQAVNVQVWPGAT-----------VREGQLVNLTCLVWTTH 1113
Query: 2755 HAQV--TWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEA 2812
AQ+ TW++ G H + L +V+ D+ Y C V GP
Sbjct: 1114 PAQLTYTWYQDGQQRLDAHS-----IPLPNVTVRDATSYRCGV----GP----------- 1153
Query: 2813 SGSSAVHVPAPGGAP----PIRIE----PSSSRVA------EGQTLDLKCVVPGQAHAQV 2858
PG AP PI ++ P + R+ GQ + C V + AQ+
Sbjct: 1154 ----------PGRAPRLSRPITLDVLYAPRNLRLTYLLESHGGQLALVLCTVDSRPPAQL 1203
Query: 2859 TWHKRGGNLPARHQVHGP---LLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSP 2915
G L + P L L P D G YSC G S+ + +E
Sbjct: 1204 ALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLE--GV 1261
Query: 2916 GPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQV--TWYKRGGSLPARHQTHG 2973
I AP A P EG + + C P AHA TWY G L +
Sbjct: 1262 RVILAPEAAVP-----------EGAPITVTCADPA-AHAPTLYTWYHNGRWL---QEGPA 1306
Query: 2974 SQLRLHLVSPADSGEYVCRA--ASGPGPEQEASFTVTVPPSEG--SSYRLRSPVISIDPP 3029
+ L + + A +G Y C+A A G + A+ V P + SS+R S S+
Sbjct: 1307 ASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQDAVLSSFR-DSRARSMAVI 1365
Query: 3030 SSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTY 3089
TV A L HDG + +V ++ N + + P+ TY
Sbjct: 1366 QCTVDSEPPAEL-ALSHDGKVLATSSGVHSLASGTGHVQVARNALRLQVQDV-PAGDDTY 1423
Query: 3090 RCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEP----RSSAR 3145
C A N G ++ L V G V+ E + V G A+ L C G P S+
Sbjct: 1424 VCTAQNLLGSISTIGRLQVEG---ARVVAEPGLDVPEGAALNLSCRLLGGPGPVGNSTFA 1480
Query: 3146 W----TRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQK----- 3196
W R+ + P L + + AG Y CLA+ G A
Sbjct: 1481 WFWNDRRLHAEPV-------------PTLAFTHVARAQAGMYHCLAELPTGAAASAPVML 1527
Query: 3197 ---------QVEVIVDTGAMAPGAPQVQAEE---AELTVEAGHTATLRCSATGSPA-PTI 3243
+ V V+ G + + A LT+ G G+PA P I
Sbjct: 1528 RVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVASSQPQGAPAEPHI 1587
Query: 3244 HWSKLRSPLPWQHRLEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVES 3297
H L SP + L D I + D G+YIC+A++ G A + V +
Sbjct: 1588 H--VLASP----NALRVD---IEALRPSDQGEYICSASNVLGSASTSTYFGVRA 1632
Score = 184 bits (466), Expect = 2e-45
Identities = 374/1696 (22%), Positives = 593/1696 (34%), Gaps = 304/1696 (17%)
Query: 2102 LRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSS 2161
L L + P DSG Y R E + + + +++ T VP P+ +
Sbjct: 100 LLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTLVTVTEE----PRVPTIASPVEL----- 150
Query: 2162 HVAEGQTLDLNCVVPG---QAHAQVTWHKRGGSLPARHQTH----------GSLLRLHQV 2208
EG +D NC P Q ++ W G PAR T G L LH
Sbjct: 151 --LEGTEVDFNCSTPYVCLQEQVRLQWQ---GQDPARSVTFNSQKFEPTGVGHLETLHMA 205
Query: 2209 TPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVV 2268
+ + A + ++ P + + + S + G+ + L+C V
Sbjct: 206 MSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGVK-ILLSPSGRNILPGELVTLTCQV 264
Query: 2269 AGQ--AHAQVTWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVT 2326
A + + W K G R Q + L++ QA+ +DAG Y C+A NG+ + ++ ++
Sbjct: 265 NSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWSDAGVYTCQAENGVGSLVSPPIS 320
Query: 2327 GTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQ--SHAQVTWHKRGGSLPVR 2384
++ P + + E QT+ L C P + S + +W+K L
Sbjct: 321 ----LHIFMAEVQVSP------AGPILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL--- 367
Query: 2385 HQTHGSLLRLYQASPADSGEYVCRVL---GSSVPLEASVLVTIEPAGSVPALGVTPTVRI 2441
H LRL+ A+ AD+G Y C V GS SV+V P P L T +
Sbjct: 368 EDAHSHTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVVNHPPL--TPVL----TAFL 421
Query: 2442 ESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPAR-----HQVHGS--------RL 2488
E+ + V L+C V + A + G L + H S RL
Sbjct: 422 ETQAGLVGI-----LHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSGTSGPNSLRL 476
Query: 2489 RLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANG 2548
+ + DSGEY C S G +++ H+ + S +A + G
Sbjct: 477 EIRDLEETDSGEYKCSATNSLGNATSTL---------DFHANAARLLI---SPAAEVVEG 524
Query: 2549 HTLDLNCLVA-SQAPHT-ITWYKRGGSLPSRHQIVGSRLRIPQVTPADSGEYVCHVSNGA 2606
+ L+C S P +WY G L H+ GS L +P + D+G Y C +G
Sbjct: 525 QAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASSTDAGSYHCRARDGH 581
Query: 2607 GSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKR 2666
+ S + P+ + + ++++ G+ L C V P A + +
Sbjct: 582 SASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGA--GRRGLLLCRVDSDPPARLQLLHK 639
Query: 2667 -----------------GGSLPSRHQTHGSHL---RLHQMSVADSGEYVCRANNNIDALE 2706
GG P T +L +H + + G Y+C A+N +
Sbjct: 640 DRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNAS 699
Query: 2707 ASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH---AQVTWHKR 2763
S + G + + I S + + EG +L C V +A A +W +
Sbjct: 700 TSATFN-----------GQATVLAIAPSHT-LQEGTEANLTCNVSREAAGSPANFSWFRN 747
Query: 2764 GGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSG-----PLEASVLVTIEASGSSAV 2818
G Q + L V+ D+ Y CR++ +G P+ SVL + SA+
Sbjct: 748 GVLWA---QGPLETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSVLYPPDRPKLSAL 804
Query: 2819 HVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLL 2878
G S +A + ++ QV H G A+ + + L
Sbjct: 805 LDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSH---GRFQAKAEANSLKL 861
Query: 2879 RLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTE 2938
+ ++ DSG Y C+ T G+ S+ + + P+P L E
Sbjct: 862 EVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ-------------E 908
Query: 2939 GQTLDLNCVVPGQAHAQVT------WYKRGGSLPARHQTHGSQLRLHLVSPADSGEYVCR 2992
GQ + L+C Q H V WY+ G L ++ + LR ++ +G Y C+
Sbjct: 909 GQAVVLSC----QVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAITLTQAGAYHCQ 961
Query: 2993 AASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSST---------VQQGQDASFKC 3043
A + PG A+ ++ P S SY R ++ + V A +
Sbjct: 962 AQA-PG---SATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRL 1017
Query: 3044 LIHDGAAPISLEWKTRNQELEDNVHIS--PNGSIITIVGTRPSNHGTYRCVASNAYGVAQ 3101
L D +L+ + +H++ PN + I G + G Y C ASN G A
Sbjct: 1018 LHGDRLVASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQAS 1077
Query: 3102 SVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTY 3161
+ + V V P V + G+ V L C+ WT + PA+L Y
Sbjct: 1078 ASADFDAQAV-NVQVWPGATV--REGQLVNLTCLV---------WT---THPAQLTYTWY 1122
Query: 3162 G----LMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQV--- 3214
+D+H++ + + DA +Y C G A + I AP ++
Sbjct: 1123 QDGQQRLDAHSI-PLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLRLTYL 1180
Query: 3215 ------QAEEAELTVEA--------GHTATLRCSATGSPAPTIHWSKLRSPLPWQHRLEG 3260
Q TV++ H L S+T + P +LR P P
Sbjct: 1181 LESHGGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQP------- 1233
Query: 3261 DTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQC 3320
+D G Y C+A SP G A ++ L +E + A+V G + + C
Sbjct: 1234 ----------RDEGFYSCSARSPLGQANTSLELRLEG--VRVILAPEAAVPEGAPITVTC 1281
Query: 3321 L---AHGTPPLTFQWSRVGSSLPGRATARNELLHFERAAPEDSGRYRCRVTNKVGSAEAF 3377
AH P + W G L A L RA +G Y C+ +
Sbjct: 1282 ADPAAHA--PTLYTWYHNGRWLQEGPAASLSFLVATRA---HAGAYSCQAQD-------- 1328
Query: 3378 AQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEG 3437
QG S PA ++ P V + C V S+ +L +G
Sbjct: 1329 ----AQGTRSSRPA-ALQVLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDG 1383
Query: 3438 GQLPPG---HSVQDGV---------LRIQNLDQSC-QGTYICQAHGPWGKAQASAQLVIQ 3484
L HS+ G LR+Q D TY+C A G +L ++
Sbjct: 1384 KVLATSSGVHSLASGTGHVQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVE 1443
Query: 3485 ALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVT------WSKVGGHLRPGIVQSGG 3538
V V G A+ C LG P P W+ H P
Sbjct: 1444 GARVVA----EPGLDVPEGAALNLSCRLLGGPGPVGNSTFAWFWNDRRLHAEPV-----P 1494
Query: 3539 VVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVRVP--AGSAAVFPC 3596
+ HV A AG Y C A G S ++L P + V V G + C
Sbjct: 1495 TLAFTHVARAQAGMYHCLAELPTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDC 1554
Query: 3597 IASGYPTPDISW---SKLDGSLPPDSR-LENNMLMLPS----------VRPQDAGTYVCT 3642
P ++ S+L S P E ++ +L S +RP D G Y+C+
Sbjct: 1555 RVDSEPLASLTLHLGSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICS 1614
Query: 3643 ATNRQGKVKAFAHLQV 3658
A+N G + V
Sbjct: 1615 ASNVLGSASTSTYFGV 1630
Score = 183 bits (464), Expect = 4e-45
Identities = 368/1547 (23%), Positives = 573/1547 (37%), Gaps = 356/1547 (23%)
Query: 2034 AQARIQVVVLSASDASPPPVKI--ESSSPSVTEGQTLDLNCVVAGS--AHAQVTWYRRGG 2089
AQ+ I + V A P VKI S ++ G+ + L C V S A + + W + G
Sbjct: 226 AQSEIHLQVKYA----PKGVKILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDGV 281
Query: 2090 SLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG-----PKEASITVSVLHGTHSGPSY 2144
L T V L LPQ + +D+G Y C+ ENG G P I ++ + + +GP
Sbjct: 282 RLQTKTGV----LHLPQAAWSDAGVYTCQAENGVGSLVSPPISLHIFMAEVQVSPAGP-- 335
Query: 2145 TPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQV--TWHKRGGSLPARHQTHGSL 2202
+ E QT+ L C P +A + + +W+K L H
Sbjct: 336 ------------------ILENQTVTLVCNTPNEAPSDLRYSWYKNHVLL---EDAHSHT 374
Query: 2203 LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIP-GPIPPVRIESSSSTVAEGQT 2261
LRLH T AD+G Y C V G E S V++ + P P+ +E+ + V
Sbjct: 375 LRLHLATRADTGFYFCEVQNVHGS-ERSGPVSVVVNHPPLTPVLTAFLETQAGLVG---- 429
Query: 2262 LDLSCVVAGQAHAQVTWYKRGGSLPAR------HQVRGS--------RLYIFQASPADAG 2307
L C V + A + GG + A H R S RL I D+G
Sbjct: 430 -ILHCSVVSEPLATLV-LSHGGHILASTSGDSDHSPRFSGTSGPNSLRLEIRDLEETDSG 487
Query: 2308 QYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNC--VVP 2365
+Y C A+N + G + L + A + + + I P +++V EGQ + L+C +
Sbjct: 488 EYKCSATNSL---------GNATSTLDFHANAAR-LLISP-AAEVVEGQAVTLSCRSGLS 536
Query: 2366 GQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQASPADSGEYVCRVL---GSSVPLEASVLV 2422
A+ +W+ G L H+ GS L L AS D+G Y CR +S P +VL
Sbjct: 537 PTPDARFSWYLNGALL---HEGPGSSLLLPAASSTDAGSYHCRARDGHSASGPSSPAVLT 593
Query: 2423 TIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQV-TWHKR-------- 2473
+ P T T R++ ++ G+ L C V A++ HK
Sbjct: 594 VLYPPRQ-----PTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQLLHKDRVVATSLP 648
Query: 2474 --------GGSLPARHQVHGSRLRLLQV---TPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522
GG P L +++ + G Y+C + G S Q
Sbjct: 649 SGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNALGNASTSATFNGQA 708
Query: 2523 RLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQA---PHTITWYKRGGSLPSRHQ 2579
V + S +L G +L C V+ +A P +W+ R G L ++
Sbjct: 709 ------------TVLAIAPSHTLQEGTEANLTCNVSREAAGSPANFSWF-RNGVLWAQGP 755
Query: 2580 IVGSRLRIPQVTPADSGEYVCHVSNGAGSR-ETSLIVTIQGSGSSHVPSVSPPIRIE-SS 2637
+ + + V D+ Y C + AG++ T +++++ + PP R + S+
Sbjct: 756 L--ETVTLLPVARTDAALYACRILTEAGAQLSTPVLLSV----------LYPPDRPKLSA 803
Query: 2638 SPTVVEGQTLDLNCVVARQPQAIITWY--------KRGGSLPS------RHQTHGSHLRL 2683
+ +G C V +P A++ + G +PS + + + L +
Sbjct: 804 LLDMGQGHMALFICTVDSRPLALLALFHGEHLLATSLGPQVPSHGRFQAKAEANSLKLEV 863
Query: 2684 HQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGET 2743
++ + DSG Y C A N + + S+ V G+ + + S S + EG+
Sbjct: 864 RELGLGDSGSYRCEATNVLGSSNTSLFFQVR---------GAWVQV---SPSPELQEGQA 911
Query: 2744 LDLNCVVPGQAHAQV------TWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMG 2797
+ L+C Q H V W++ G L ++ + LR ++ +G Y C+
Sbjct: 912 VVLSC----QVHTGVPEGTSYRWYRDGQPL---QESTSATLRFAAITLTQAGAYHCQAQ- 963
Query: 2798 SSGPLEASVLVTIEASGSSAV-HV---------PAPGGAPPIRIE---PSSSRVAEGQTL 2844
+ G S+ I S A HV P G R++ P+ R+ G L
Sbjct: 964 APGSATTSLAAPISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRL 1023
Query: 2845 DLKCV--VPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTL 2902
+ V G + H R ++HG +L D G Y C+ + + G
Sbjct: 1024 VASTLQGVGGPEGSSPRLHVAVAPNTLRLEIHGAMLE-------DEGVYICEASNTLGQA 1076
Query: 2903 EASVLVTIEPSSPGPIPAPGLAQPIYIEA-SSSHVTEGQTLDLNCVVPGQAHAQV--TWY 2959
AS A AQ + ++ + V EGQ ++L C+V AQ+ TWY
Sbjct: 1077 SAS--------------ADFDAQAVNVQVWPGATVREGQLVNLTCLVWTTHPAQLTYTWY 1122
Query: 2960 KRGGSLPARHQTHGSQLRLHLVSPADSGEYVCRAASGPGPEQEASFTVTV-----PPSEG 3014
+ G + + + L V+ D+ Y C PG S +T+ P +
Sbjct: 1123 QDG-----QQRLDAHSIPLPNVTVRDATSYRC-GVGPPGRAPRLSRPITLDVLYAPRNLR 1176
Query: 3015 SSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHIS-PNG 3073
+Y L S GQ A C + D P L + L + S PN
Sbjct: 1177 LTYLLES------------HGGQLALVLCTV-DSRPPAQLALSHAGRLLASSTAASVPNT 1223
Query: 3074 SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTV----SVLPEG-PV------ 3122
+ + G +P + G Y C A + G A + + L + G + + +PEG P+
Sbjct: 1224 LRLELRGPQPRDEGFYSCSARSPLGQANTSLELRLEGVRVILAPEAAVPEGAPITVTCAD 1283
Query: 3123 ----------------WVKVGKAVTLECVSAGEPRS--------SARWTRISSTPAKLEQ 3158
W++ G A +L + A + A+ TR SS PA L Q
Sbjct: 1284 PAAHAPTLYTWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTR-SSRPAAL-Q 1341
Query: 3159 RTYGLMD------------SHAVLQ--ISSAKPSD--------------------AGT-Y 3183
Y D S AV+Q + S P++ +GT +
Sbjct: 1342 VLYAPQDAVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGH 1401
Query: 3184 VCLAQNALG---------------TAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHT 3228
V +A+NAL TAQ + I G + +V AE L V G
Sbjct: 1402 VQVARNALRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGARVVAEPG-LDVPEGAA 1460
Query: 3229 ATLRCSATGSPAPTIHWSKLRSPLPW---QHRLEGD---TLIIPRVAQQDSGQYICNATS 3282
L C G P P + S W RL + TL VA+ +G Y C A
Sbjct: 1461 LNLSCRLLGGPGPVGN-----STFAWFWNDRRLHAEPVPTLAFTHVARAQAGMYHCLAEL 1515
Query: 3283 PAG-HAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTP--PLTFQWSR--VGS 3337
P G A A ++L V PP T+ + G L C P LT V S
Sbjct: 1516 PTGAAASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHLGSRLVAS 1575
Query: 3338 SLPGRATARNEL----------LHFERAAPEDSGRYRCRVTNKVGSA 3374
S P A A + + E P D G Y C +N +GSA
Sbjct: 1576 SQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSA 1622
Score = 156 bits (394), Expect = 5e-37
Identities = 349/1574 (22%), Positives = 561/1574 (35%), Gaps = 317/1574 (20%)
Query: 2154 IRIEPSSSHVAEGQTLDLNCVVPGQ--AHAQVTWHKRGGSLPARHQTHGSLLRLHQVTPA 2211
I + PS ++ G+ + L C V A + + W K G R QT +L L Q +
Sbjct: 243 ILLSPSGRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWS 298
Query: 2212 DSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQ 2271
D+G Y C G L S +++ + + P + + E QT+ L C +
Sbjct: 299 DAGVYTCQAENGVGSL-VSPPISLHIFMAEVQVSP------AGPILENQTVTLVCNTPNE 351
Query: 2272 AHAQV--TWYKRGGSLPARHQVRGSRLYIFQASPADAGQYVCRASN--GMEASITVTV-- 2325
A + + +WYK L H L + A+ AD G Y C N G E S V+V
Sbjct: 352 APSDLRYSWYKNHVLLEDAHS---HTLRLHLATRADTGFYFCEVQNVHGSERSGPVSVVV 408
Query: 2326 -----TGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGS 2380
T A L AG + S +A V+ H +
Sbjct: 409 NHPPLTPVLTAFLETQAGLVGILHCSVVSEPLA-------TLVLSHGGHILASTSGDSDH 461
Query: 2381 LPVRHQTHGS---LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTP 2437
P T G L + DSGEY C S + T++ + L ++P
Sbjct: 462 SPRFSGTSGPNSLRLEIRDLEETDSGEYKCSATNSL----GNATSTLDFHANAARLLISP 517
Query: 2438 TVRIESSSSQVAEGQTLDLNCL--VAGQAHAQVTWHKRGGSLPARHQVHGSRLRLLQVTP 2495
+++V EGQ + L+C ++ A+ +W+ G L H+ GS L L +
Sbjct: 518 -------AAEVVEGQAVTLSCRSGLSPTPDARFSWYLNGALL---HEGPGSSLLLPAASS 567
Query: 2496 ADSGEYVCRVV---GSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLD 2552
D+G Y CR +SG +VL + + + R++ +A G
Sbjct: 568 TDAGSYHCRARDGHSASGPSSPAVLTVLYP------PRQPTFTTRLDLDAAGAGAGRRGL 621
Query: 2553 LNCLVASQAPHTITWYKR----GGSLPS------------RHQIVGS----RLRIPQVTP 2592
L C V S P + + SLPS R ++ + R+ I
Sbjct: 622 LLCRVDSDPPARLQLLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLL 681
Query: 2593 ADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCV 2652
+ G Y+C SN G+ TS +G + V +++P S T+ EG +L C
Sbjct: 682 EEEGLYLCEASNALGNASTSATF----NGQATVLAIAP-------SHTLQEGTEANLTCN 730
Query: 2653 VARQPQ---AIITWYKRG-----GSLPSRHQTHGSHLRLHQMSVADSGEYVCRANNNIDA 2704
V+R+ A +W++ G G L + + L ++ D+ Y CR A
Sbjct: 731 VSREAAGSPANFSWFRNGVLWAQGPLET--------VTLLPVARTDAALYACRILTEAGA 782
Query: 2705 -LEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVA------EGETLDLNCVVPGQAHAQ 2757
L +++SV P + ++ H+A + L L + G+ H
Sbjct: 783 QLSTPVLLSVLYPPDRPK-----LSALLDMGQGHMALFICTVDSRPLALLALFHGE-HLL 836
Query: 2758 VTWHKRGGSLPSHHQTRGS------RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIE 2811
T G +PSH + + +L + + DSG Y C G S+ +
Sbjct: 837 AT--SLGPQVPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVR 894
Query: 2812 ASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVT------WHKRGG 2865
+ +++ PS + EGQ + L C Q H V W++ G
Sbjct: 895 GAW--------------VQVSPSPE-LQEGQAVVLSC----QVHTGVPEGTSYRWYRDGQ 935
Query: 2866 NLPARHQVHGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQ 2925
L + LR ++ +G Y CQ +PG LA
Sbjct: 936 PL---QESTSATLRFAAITLTQAGAYHCQA-----------------QAPGSATT-SLAA 974
Query: 2926 PIYIEASSS--HVTEGQTLD--------LNCVVPGQAHAQVTWYKRGGSLPARHQ----T 2971
PI + S + HVT +D L C V AQ+ + + Q
Sbjct: 975 PISLHVSYAPRHVTLTTLMDTGPGRLGLLLCRVDSDPPAQLRLLHGDRLVASTLQGVGGP 1034
Query: 2972 HGSQLRLHL-VSP------------ADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYR 3018
GS RLH+ V+P D G Y+C A++ G S + +
Sbjct: 1035 EGSSPRLHVAVAPNTLRLEIHGAMLEDEGVYICEASNTLGQA-----------SASADFD 1083
Query: 3019 LRSPVISIDPPSSTVQQGQDASFKCLIHDG-AAPISLEWKTRNQELEDNVHISPNGSIIT 3077
++ + + P +TV++GQ + CL+ A ++ W Q+ D H P ++
Sbjct: 1084 AQAVNVQVWP-GATVREGQLVNLTCLVWTTHPAQLTYTWYQDGQQRLD-AHSIPLPNVTV 1141
Query: 3078 IVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSA 3137
T +YRC GV + P T+ VL + +T S
Sbjct: 1142 RDAT------SYRC------GVGPPGRAPRLSRPITLDVL-----YAPRNLRLTYLLESH 1184
Query: 3138 GEPRSSARWTRISSTPAKLEQRTYG--LMDSHAV-------LQISSAKPSDAGTYVCLAQ 3188
G + T S PA+L G L S A L++ +P D G Y C A+
Sbjct: 1185 GGQLALVLCTVDSRPPAQLALSHAGRLLASSTAASVPNTLRLELRGPQPRDEGFYSCSAR 1244
Query: 3189 NALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKL 3248
+ LG A +E+ ++ G + A EA V G T+ C+ + APT++
Sbjct: 1245 SPLGQANTSLELRLE------GVRVILAPEA--AVPEGAPITVTCADPAAHAPTLY---- 1292
Query: 3249 RSPLPWQHR----LEGD--TLIIPRVAQQDSGQYICNATSPAG-HAEATIILHVESPPYA 3301
W H EG +L + +G Y C A G + L V P
Sbjct: 1293 ----TWYHNGRWLQEGPAASLSFLVATRAHAGAYSCQAQDAQGTRSSRPAALQVLYAPQD 1348
Query: 3302 TTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRA-------------TARNE 3348
+ +A +QC PP S G L + ARN
Sbjct: 1349 AVLSSFRDSRARSMAVIQCTVDSEPPAELALSHDGKVLATSSGVHSLASGTGHVQVARNA 1408
Query: 3349 LLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQL 3408
L + P Y C N +GS +L V+G V P L
Sbjct: 1409 LRLQVQDVPAGDDTYVCTAQNLLGSISTIGRLQVEGA---------------RVVAEPGL 1453
Query: 3409 ETKSIGASVEFHCAVPSDRG----TQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTY 3464
+ GA++ C + G + WF +L H+ L ++ ++ G Y
Sbjct: 1454 DVPE-GAALNLSCRLLGGPGPVGNSTFAWFWNDRRL---HAEPVPTLAFTHVARAQAGMY 1509
Query: 3465 ICQAHGPWGKAQASAQLVIQAL-----PSVLI------NIRTSVQTVVVGHAVEFECLAL 3513
C A P G A ASA ++++ L P++++ +R + V + L L
Sbjct: 1510 HCLAELPTGAA-ASAPVMLRVLYPPKTPTMMVFVEPEGGLRGILDCRVDSEPLASLTLHL 1568
Query: 3514 GD---PKPQVTWSKVGGHLRPGIVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLL 3570
G Q + H+ + V I + +D G+Y C+A+N G+ +
Sbjct: 1569 GSRLVASSQPQGAPAEPHIHVLASPNALRVDIEALRPSDQGEYICSASNVLGSASTSTYF 1628
Query: 3571 LVQALPQISMPQEV 3584
V+AL ++ Q++
Sbjct: 1629 GVRALHRLHQFQQL 1642
Score = 117 bits (292), Expect = 3e-25
Identities = 221/958 (23%), Positives = 352/958 (36%), Gaps = 170/958 (17%)
Query: 2768 PSHHQTRGSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAP 2827
P H R L L + P DSG Y R S + V T+ V V P
Sbjct: 93 PEH---RVCNLLLKDLQPEDSGSYNFRFEISEVNRWSDVKGTL-------VTVTEEPRVP 142
Query: 2828 PIRIEPSSSRVAEGQTLDLKCVVPG---QAHAQVTWHKRGGNLPARHQVH---------- 2874
I S + EG +D C P Q ++ W G PAR
Sbjct: 143 TIA---SPVELLEGTEVDFNCSTPYVCLQEQVRLQWQ---GQDPARSVTFNSQKFEPTGV 196
Query: 2875 GPLLRLNQ-VSPADSGEY-SCQVTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEAS 2932
G L L+ +S D G CQ++ ++ ++ + + ++ + G I + S
Sbjct: 197 GHLETLHMAMSWQDHGRILRCQLSVANHRAQSEIHLQVKYAPKGV--------KILLSPS 248
Query: 2933 SSHVTEGQTLDLNCVVPGQ--AHAQVTWYKRGGSLPARHQTHGSQLRLHLVSPADSGEYV 2990
++ G+ + L C V A + + W K G R QT L L + +D+G Y
Sbjct: 249 GRNILPGELVTLTCQVNSSYPAVSSIKWLKDG----VRLQTKTGVLHLPQAAWSDAGVYT 304
Query: 2991 CRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI-HDGA 3049
C+A +G G ++ PP + V P+ + + Q + C ++
Sbjct: 305 CQAENGVG-------SLVSPPISLHIFMAEVQV----SPAGPILENQTVTLVCNTPNEAP 353
Query: 3050 APISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQS-VVNLSV 3108
+ + W + LED + + ++ + TR ++ G Y C N +G +S V++ V
Sbjct: 354 SDLRYSWYKNHVLLED----AHSHTLRLHLATR-ADTGFYFCEVQNVHGSERSGPVSVVV 408
Query: 3109 HGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR----ISSTPAKLEQ--RTYG 3162
+ PP VL + + G L C EP ++ + ++ST + R G
Sbjct: 409 NHPPLTPVLTAF-LETQAGLVGILHCSVVSEPLATLVLSHGGHILASTSGDSDHSPRFSG 467
Query: 3163 LMDSHAV-LQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAM--APGAPQVQAEEA 3219
+++ L+I + +D+G Y C A N+LG A ++ + + +P A V+
Sbjct: 468 TSGPNSLRLEIRDLEETDSGEYKCSATNSLGNATSTLDFHANAARLLISPAAEVVE---- 523
Query: 3220 ELTVEAGHTATLRCSATGSPAPTIHWS-KLRSPLPWQHRLEGDTLIIPRVAQQDSGQYIC 3278
G TL C + SP P +S L L H G +L++P + D+G Y C
Sbjct: 524 ------GQAVTLSCRSGLSPTPDARFSWYLNGAL--LHEGPGSSLLLPAASSTDAGSYHC 575
Query: 3279 ------NATSPAGHAEATIILHVESPPYATTVP-EHASVQAGETVQLQCLAHGTPPLTFQ 3331
+A+ P+ A T++ P + T + + A AG L C PP Q
Sbjct: 576 RARDGHSASGPSSPAVLTVLYPPRQPTFTTRLDLDAAGAGAGRRGLLLCRVDSDPPARLQ 635
Query: 3332 WSR----VGSSLPG--------------RATARNELLHFERAAP--EDSGRYRCRVTNKV 3371
V +SLP + T LL E P E+ G Y C +N +
Sbjct: 636 LLHKDRVVATSLPSGGGCSTCGGCSPRMKVTKAPNLLRVEIHNPLLEEEGLYLCEASNAL 695
Query: 3372 GSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRG--- 3428
G+A +TS TV T G C V +
Sbjct: 696 GNA----------------STSATFNGQATVLAIAPSHTLQEGTEANLTCNVSREAAGSP 739
Query: 3429 TQLRWFKEGGQLPPGHSVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
WF+ G G +L + D + Y C+ +A AQL L S
Sbjct: 740 ANFSWFRNGVLWAQGPLETVTLLPVARTDAAL---YACRI-----LTEAGAQLSTPVLLS 791
Query: 3489 VLINIRTSVQTVVV----GHAVEFECLALGDPKPQVTWSKVGGH------LRPGIVQSGG 3538
VL + ++ GH F C D +P + G L P + G
Sbjct: 792 VLYPPDRPKLSALLDMGQGHMALFICTV--DSRPLALLALFHGEHLLATSLGPQVPSHGR 849
Query: 3539 V----------VRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQ-ALPQISMPQEVRVP 3587
+ + + L D+G YRC ATN G++ + + V+ A Q+S E++
Sbjct: 850 FQAKAEANSLKLEVRELGLGDSGSYRCEATNVLGSSNTSLFFQVRGAWVQVSPSPELQ-- 907
Query: 3588 AGSAAVFPC-IASGYPT-PDISWSKLDGSLPPDSRLENNMLMLPSVRPQDAGTYVCTA 3643
G A V C + +G P W + DG P + L ++ AG Y C A
Sbjct: 908 EGQAVVLSCQVHTGVPEGTSYRWYR-DGQ--PLQESTSATLRFAAITLTQAGAYHCQA 962
Score = 33.5 bits (75), Expect = 4.8
Identities = 15/40 (37%), Positives = 21/40 (52%)
Query: 447 IPSHPRVTVTSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+PSH R +E L +R++ D G+Y CEA N G
Sbjct: 844 VPSHGRFQAKAEANSLKLEVRELGLGDSGSYRCEATNVLG 883
>gi|21359935 Down syndrome cell adhesion molecule like 1 [Homo
sapiens]
Length = 2113
Score = 185 bits (469), Expect = 1e-45
Identities = 201/777 (25%), Positives = 300/777 (38%), Gaps = 123/777 (15%)
Query: 2946 CVVPGQAHAQVTWYKRGGS----LP-ARHQTHGSQLRLHLVSPA------DSGEYVCRAA 2994
C G A + WY G +P RH L+L+ SP+ +Y C A
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
Query: 2995 SGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLI----HDGAA 3050
+ G + + V E + R+ +G A FKCLI + +
Sbjct: 167 NAAGKIRSPNIRVKAVFREPYTVRVED---------QRSMRGNVAVFKCLIPSSVQEYVS 217
Query: 3051 PISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAY--------GVAQS 3102
+S E T + E I+ +G + + TYRC+ + Y G S
Sbjct: 218 VVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLS 277
Query: 3103 VVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYG 3162
V + + P + VW G V L C ++G P + RW + P + R
Sbjct: 278 VTDPAESIPTILDGFHSQEVWA--GHTVELPCTASGYPIPAIRWLK-DGRPLPADSRWTK 334
Query: 3163 LMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAP-QVQAEEAEL 3221
+ L IS + D+GTY+C N G+A+ TG + P V +L
Sbjct: 335 RITG---LTISDLRTEDSGTYICEVTNTFGSAEA-------TGILMVIDPLHVTLTPKKL 384
Query: 3222 TVEAGHTATLRCSATGSPAPTIHWSK-LRSPLPWQ----HRLEGDTLIIPRVAQQDSGQY 3276
G T L C+ TGSP TI W + LP + L +TL+I + SG Y
Sbjct: 385 KTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAY 444
Query: 3277 ICNATSPAGHAEATIILHVE--SPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWS- 3333
C AT A A+ I+ +E +P ++ E V GE L C A G PP T W+
Sbjct: 445 QCFATRKAQTAQDFAIIALEDGTPRIVSSFSEKV-VNPGEQFSLMCAAKGAPPPTVTWAL 503
Query: 3334 ------RVGSSLPGRATARN--ELLHFERAAPE--DSGRYRCRVTNKVGSAEAFAQLLVQ 3383
R GS + T + + H P+ D G YRC N VGSAE A++ V+
Sbjct: 504 DDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR 563
Query: 3384 GPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPG 3443
GPP +I A + G +C V ++W+K+ LP
Sbjct: 564 GPPSIRAMRNITAVA---------------GRDTLINCRVIGYPYYSIKWYKDALLLPDN 608
Query: 3444 HS---VQDGVLRIQNLDQSC-QGTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQT 3499
H ++G L++ ++ + +G Y+C QL I V + + +Q
Sbjct: 609 HRQVVFENGTLKLTDVQKGMDEGEYLCSV-------LIQPQLSISQSVHVAVKVPPLIQP 661
Query: 3500 -----VVVGHAVEFECL-ALGDPKPQVTWSKVGGHLRPGIVQSGGV----------VRIA 3543
+G + C+ + GD ++TW K G I+ GV ++I+
Sbjct: 662 FEFPPASIGQLLYIPCVVSSGDMPIRITWRKDG----QVIISGSGVTIESKEFMSSLQIS 717
Query: 3544 HVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ-ISMPQEVRVPAGSAAVFPCIASGYP 3602
V L G Y C A+NAA T L+V+ P+ + P G A V C GYP
Sbjct: 718 SVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYP 777
Query: 3603 TPDISWSKLDGSLPPDSR-----------LENNMLMLPSVRPQDAGTYVCTATNRQG 3648
P + W GS P L N+ L++ V +D G Y+C A+N G
Sbjct: 778 PPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVG 834
Score = 176 bits (446), Expect = 5e-43
Identities = 235/1041 (22%), Positives = 387/1041 (37%), Gaps = 166/1041 (15%)
Query: 2266 CVVAGQAHAQVTWYKRGGS----LP-ARHQVRGSRLYIFQASPA------DAGQYVCRAS 2314
C AG A + WY G +P RH L ++ SP+ Y C A
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
Query: 2315 NGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSH---AQ 2371
N + N+ A +P + + G C++P +
Sbjct: 167 NAAGK--------IRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSV 218
Query: 2372 VTWHKRGGSLPVRHQT----HGSLLRLYQASPADSGEYVC----RVLGSSVPLEASVLVT 2423
V+W K S+ H+ HG L Y C + G + + L
Sbjct: 219 VSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSV 278
Query: 2424 IEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGGSLPA--RH 2481
+PA S+P T+ S +V G T++L C +G + W K G LPA R
Sbjct: 279 TDPAESIP------TILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW 332
Query: 2482 QVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESS 2541
+ L + + DSG Y+C V + G+ EA+ ++ + L V +
Sbjct: 333 TKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH----------VTLTPK 382
Query: 2542 SASLANGHTLDLNCLVASQAPHTITWYKRGG-SLP----SRHQIVGSRLRIPQVTPADSG 2596
G T+ L+C + TI WY+ LP S + L I + SG
Sbjct: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSG 442
Query: 2597 EYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQ 2656
Y C + A + + I+ ++ +P I S V G+ L C
Sbjct: 443 AYQCFATRKAQTAQDFAIIALEDG--------TPRIVSSFSEKVVNPGEQFSLMCAAKGA 494
Query: 2657 PQAIITW------YKRGGSLPSRHQTHG-----SHLRLHQMSVADSGEYVCRANNNIDAL 2705
P +TW R GS + T SH+ + + D G Y C A N + +
Sbjct: 495 PPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSA 554
Query: 2706 EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGG 2765
E I+V G PS IR + + VA +TL +NC V G + + W+K
Sbjct: 555 EYQARINV---RGPPS-------IRAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDAL 603
Query: 2766 SLPSHHQT---RGSRLRLHHVSPA-DSGEYVCRVMGSSGPLEASVLVTIEASGSSAVH-- 2819
LP +H+ L+L V D GEY+C SVL+ + S S +VH
Sbjct: 604 LLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC-----------SVLIQPQLSISQSVHVA 652
Query: 2820 VPAPGGAPPIRIEPSSSRVAEGQTLDLKCVV-PGQAHAQVTWHK------RGGNLPARHQ 2872
V P P P+S GQ L + CVV G ++TW K G + +
Sbjct: 653 VKVPPLIQPFEFPPASI----GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESK 708
Query: 2873 VHGPLLRLNQVSPADSGEYSCQVTGSSGTL--EASVLVTIEPSSPGPIPAPGLAQPIYIE 2930
L+++ VS +G Y+C + ++ T+ E ++V + P + P IY
Sbjct: 709 EFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRF---VVQPNNQDGIY-- 763
Query: 2931 ASSSHVTEGQTLDLNCVVPGQAHAQVTW-YKRGGSLPARHQ----------THGSQLRLH 2979
G+ LNC V G +V W + +G P ++ S L +
Sbjct: 764 --------GKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIR 815
Query: 2980 LVSPADSGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQ-QGQD 3038
V D G Y+C+A++G G + S +TV + P + P++T+ +G
Sbjct: 816 HVLEEDIGYYLCQASNGVGTDISKSMFLTV----------KIPAMITSHPNTTIAIKGHA 865
Query: 3039 ASFKCLIHDGAAPISLEWKTRNQELEDN------VHISPNG-SIITIVGTRPSNHGT--- 3088
C G PI + W+ + ++ + + NG +++ + +P++ G
Sbjct: 866 KELNCTAR-GERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVF 924
Query: 3089 YRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTR 3148
+ C A N+YG + ++ L+V PP PE + +++ L + S
Sbjct: 925 FSCHAINSYGEDRGLIQLTVQEPPDP---PELEIREVKARSMNLRWTQRFDGNSIITGFD 981
Query: 3149 I----SSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNALGTAQKQVEVIVDT 3204
I S +Q T + + I P+ + + N +G ++ E+ + T
Sbjct: 982 IEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTIST 1041
Query: 3205 GAMAPGAPQVQAEEAELTVEA 3225
AP P + +T ++
Sbjct: 1042 EEAAPDGPPMDVTLQPVTSQS 1062
Score = 170 bits (431), Expect = 3e-41
Identities = 290/1270 (22%), Positives = 461/1270 (36%), Gaps = 244/1270 (19%)
Query: 1966 QVHAGRTVRLYCRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTADAGFYLC 2025
+V AG TV L C A+G P I W K+G LP +R + I L I + T D+G Y+C
Sbjct: 296 EVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKR-ITGLTISDLRTEDSGTYIC 354
Query: 2026 VATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWY 2085
T+ G+A+A ++V+ + P K+++ G T+ L+C + GS + WY
Sbjct: 355 EVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGI-----GSTVILSCALTGSPEFTIRWY 409
Query: 2086 RRGGSLPPHTQV-----HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHS 2140
R + P + L + + SG Y C + + +++ GT
Sbjct: 410 RNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTP- 468
Query: 2141 GPSYTPVPGSTRPIRIEPSSSH--VAEGQTLDLNCVVPGQAHAQVTWH------KRGGSL 2192
RI S S V G+ L C G VTW R GS
Sbjct: 469 --------------RIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSH 514
Query: 2193 PARHQT--HGSLLRLHQVTP---ADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPV 2247
T G+ + VT D G Y C G E + + GP P +
Sbjct: 515 RTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR-----GP-PSI 568
Query: 2248 RIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQ----VRGSRLYIFQASP 2303
R + + VA TL ++C V G + + WYK LP H+ G+
Sbjct: 569 RAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKG 627
Query: 2304 ADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGS-TQPIRIEPSSSQVAEGQTLDLNC 2362
D G+Y+C + SI +Q ++A QP P+S GQ L + C
Sbjct: 628 MDEGEYLCSVLIQPQLSI------SQSVHVAVKVPPLIQPFEFPPASI----GQLLYIPC 677
Query: 2363 VV-PGQSHAQVTWHK------RGGSLPVRHQTHGSLLRLYQASPADSGEYVCRV--LGSS 2413
VV G ++TW K G + + + S L++ S +G Y C ++
Sbjct: 678 VVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAAT 737
Query: 2414 VPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTW-HK 2472
V E ++V V P ++ ++ G+ LNC V G +V W H
Sbjct: 738 VSRERQLIVR-----------VPPRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHA 786
Query: 2473 RGGSLPARHQ----------VHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522
+G P ++ + S L + V D G Y+C+ GT
Sbjct: 787 KGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTD---------- 836
Query: 2523 RLSGSHSQGVAYPVRIES--SSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQI 2580
+S S V P I S ++ GH +LNC + P I W ++G ++ ++
Sbjct: 837 -ISKSMFLTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRW-EKGDTVIDPDRV 894
Query: 2581 -------------VGSRLRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPS 2627
V S L++ DS + CH N G + +T+Q P
Sbjct: 895 MRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQ------EPP 948
Query: 2628 VSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWY-----KRGGSLPSRHQTHGSHLR 2682
P + I V+ ++++L +IIT + + S + T
Sbjct: 949 DPPELEIRE-----VKARSMNLRWTQRFDGNSIITGFDIEYKNKSDSWDFKQSTRNISPT 1003
Query: 2683 LHQMSVAD---SGEYVCR--ANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSH 2737
++Q ++ D + Y R + N I E S +++S +P P + ++ +S S
Sbjct: 1004 INQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPDGPPMDVTLQPVTSQS- 1062
Query: 2738 VAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHHQTRGSRLRLHHVSPADSGEYVCRVMG 2797
QVTW L + RG ++ SP +G+Y M
Sbjct: 1063 ------------------IQVTWKAPKKEL-QNGVIRGYQIGYRENSPGSNGQYSIVEMK 1103
Query: 2798 SSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAH-- 2855
++G E L ++ V V A A PSSS + D+ P
Sbjct: 1104 ATGDSEVYTLDNLKKFAQYGVVVQAFNRA---GTGPSSSEINATTLEDVPSQPPENVRAL 1160
Query: 2856 ------AQVTWHKRGGNLPARHQVHGPL--LRLNQVSPADSGE----------------- 2890
A ++W + P R ++G L R+ S GE
Sbjct: 1161 SITSDVAVISWSE-----PPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTTRERVELR 1215
Query: 2891 -------YSCQV---TGSSGTLEASVL-VTIEPSSPGPIPA-----PGLAQPIYIEASSS 2934
YS QV T + + +SVL + + PGP PA P A + +
Sbjct: 1216 GMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGP-PAGIKAVPSSASSVVVSWLPP 1274
Query: 2935 HVTEG--QTLDLNCVVPGQAHAQVTWYKRGGS---LPARHQTHGSQLRLHLVSPADSG-- 2987
G + + C PG + Y+ H G Q L + + +G
Sbjct: 1275 TKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRG 1334
Query: 2988 ---EYVCRAASGPGPEQEASF--TVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFK 3042
E V +G P + SF TVT P + +R P S+ P+ V+ +D+
Sbjct: 1335 NSSEKVTIEPAGKAPAKIISFGGTVTTPWMKD----VRLPCNSVGDPAPAVKWTKDS--- 1387
Query: 3043 CLIHDGAAPISLEWKTRNQELEDNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQS 3102
D A P+S ++ + I NG+++ + + + G Y C A+N G
Sbjct: 1388 ---EDSAIPVS---------MDGHRLIHTNGTLL-LRAVKAEDSGYYTCTATNTGGFDTI 1434
Query: 3103 VVNLSVHGPP 3112
+VNL V PP
Sbjct: 1435 IVNLLVQVPP 1444
Score = 166 bits (421), Expect = 4e-40
Identities = 335/1465 (22%), Positives = 522/1465 (35%), Gaps = 269/1465 (18%)
Query: 1977 CRAAGVPSATITWRKEGGSL---PPQARSERTDIATLLIPAITTADAGF-----YLCVAT 2028
C AAG PSA + W G P R + L P +A F Y C A
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
Query: 2029 SPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAH---AQVTWY 2085
+ AG + R + + A P V++E G C++ S + V+W
Sbjct: 167 NAAG--KIRSPNIRVKAVFREPYTVRVEDQRSM--RGNVAVFKCLIPSSVQEYVSVVSWE 222
Query: 2086 RRGGSLPPHTQV----HGSRLRLPQVSPADS-GEYVCRVEN---GSGPKEASITVSVLHG 2137
+ S+ P + HG L + V D+ Y C ++ G + +SV
Sbjct: 223 KDTVSIIPEHRFFITYHGG-LYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDP 281
Query: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPA--R 2195
S P T + G S V G T++L C G + W K G LPA R
Sbjct: 282 AESIP--TILDGF--------HSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSR 331
Query: 2196 HQTHGSLLRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSST 2255
+ L + + DSG Y+C V T G EA+ ++ + I P+ + +
Sbjct: 332 WTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMV--------IDPLHVTLTPKK 383
Query: 2256 VAEG--QTLDLSCVVAGQAHAQVTWYKRGGS-LPARH-QVRG---SRLYIFQASPADAGQ 2308
+ G T+ LSC + G + WY+ LP +RG L I A + +G
Sbjct: 384 LKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGA 443
Query: 2309 YVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQ--VAEGQTLDLNCVVPG 2366
Y C A+ + T A +A G+ RI S S+ V G+ L C G
Sbjct: 444 YQCFATRKAQ-------TAQDFAIIALEDGTP---RIVSSFSEKVVNPGEQFSLMCAAKG 493
Query: 2367 QSHAQVTWHK------RGGSLPVRHQTHG-----SLLRLYQASPADSGEYVC--RVLGSS 2413
VTW R GS T S + + D G Y C R L S
Sbjct: 494 APPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGS 553
Query: 2414 VPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKR 2473
+A + V P++R + + VA TL +NC V G + + W+K
Sbjct: 554 AEYQARINVR-----------GPPSIRAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKD 601
Query: 2474 GGSLPARHQ---VHGSRLRLLQVTPA-DSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHS 2529
LP H+ L+L V D GEY+C SVL+ Q +S S
Sbjct: 602 ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC-----------SVLIQPQLSISQSVH 650
Query: 2530 QGVAYPVRIESSSASLAN-GHTLDLNCLVAS-QAPHTITWYKRGGSLPSRHQIV------ 2581
V P I+ A+ G L + C+V+S P ITW K G + S +
Sbjct: 651 VAVKVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEF 710
Query: 2582 GSRLRIPQVTPADSGEYVCHVSNGAG--SRETSLIVTIQGSGSSHVPSVSPPIRIESSSP 2639
S L+I V+ +G Y C SN A SRE LIV V P ++ ++
Sbjct: 711 MSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVR-----------VPPRFVVQPNNQ 759
Query: 2640 TVVEGQTLDLNCVVARQPQAIITW-YKRGGSLPSRHQT----------HGSHLRLHQMSV 2688
+ G+ LNC V P + W + +G P ++ S L + +
Sbjct: 760 DGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLE 819
Query: 2689 ADSGEYVCRANNNIDA-LEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLN 2747
D G Y+C+A+N + + S+ ++V A S P +++ I+ G +LN
Sbjct: 820 EDIGYYLCQASNGVGTDISKSMFLTVKIPAMITSHPNTTIAIK----------GHAKELN 869
Query: 2748 CVVPGQAHAQVTWHKRGGSLPSHHQTRG------------SRLRLHHVSPADSGEYVCRV 2795
C G+ + W K + R S L+L DS + C
Sbjct: 870 CTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHA 929
Query: 2796 MGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAH 2855
+ S G + +T++ P P ++ S + Q D ++ G
Sbjct: 930 INSYGEDRGLIQLTVQEP-------PDPPELEIREVKARSMNLRWTQRFDGNSIITG--- 979
Query: 2856 AQVTWHKRGGNLPARHQVHGPLLRLNQVSPAD---SGEYSCQVTGSS--GTLEASVLVTI 2910
+ + + + + +NQ + D + YS ++ + G E S +TI
Sbjct: 980 FDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTI 1039
Query: 2911 EPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYK---------- 2960
P +G +D+ QVTW
Sbjct: 1040 STEEAAP--------------------DGPPMDVTLQPVTSQSIQVTWKAPKKELQNGVI 1079
Query: 2961 RGGSLPARHQTHGSQLRLHLV---SPADSGEYVC-----------------RAASGPGPE 3000
RG + R + GS + +V + DS Y RA +GP
Sbjct: 1080 RGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSS 1139
Query: 3001 QEASFTV----TVPPSEGSSYRLRSPVISI---DPPSST---VQQGQDASFKCLIHDGAA 3050
+ + T+ + PP + + S V I +PP ST V +G F L DG
Sbjct: 1140 EINATTLEDVPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEW 1199
Query: 3051 PISLEWKTRNQELE-DNVHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLS-- 3107
T + +E + N S+ + T+ + GV SV+ +
Sbjct: 1200 GEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGD------------GVRSSVLYIQTK 1247
Query: 3108 --VHGPPT-VSVLPEGPVWVKVGKAVTLECVSAGEPRSSAR-WTRISSTPAKLEQRTYGL 3163
V GPP + +P +V + + +P R +T S+P +
Sbjct: 1248 EDVPGPPAGIKAVPSS------ASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEY 1301
Query: 3164 MDSHAVLQISSAKPSDAGTYVC--LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAEL 3221
S L A + Y+ A + G +V ++ AP ++ + +
Sbjct: 1302 ETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPA--KIISFGGTV 1359
Query: 3222 TVEAGHTATLRCSATGSPAPTIHWSKLR--SPLPWQ---HRL--EGDTLIIPRVAQQDSG 3274
T L C++ G PAP + W+K S +P HRL TL++ V +DSG
Sbjct: 1360 TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG 1419
Query: 3275 QYICNATSPAGHAEATIILHVESPP 3299
Y C AT+ G + L V+ PP
Sbjct: 1420 YYTCTATNTGGFDTIIVNLLVQVPP 1444
Score = 165 bits (417), Expect = 1e-39
Identities = 208/884 (23%), Positives = 321/884 (36%), Gaps = 115/884 (13%)
Query: 2848 CVVPGQAHAQVTWHKRGGN----LPARHQVHGP-LLRLNQVSPA------DSGEYSCQVT 2896
C G A + W+ G+ +P VH L+L SP+ +Y C
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
Query: 2897 GSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAH--- 2953
++G + SP +P + G C++P
Sbjct: 167 NAAGKIR----------SPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYV 216
Query: 2954 AQVTWYKRGGSLPARHQ---THGSQLRLHLVSPADS-GEYVC---RAASGPGPEQEASFT 3006
+ V+W K S+ H+ T+ L + V D+ Y C SG + +
Sbjct: 217 SVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
Query: 3007 VTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDN 3066
P+E P I S V G C P ++ W + L +
Sbjct: 277 SVTDPAESI------PTILDGFHSQEVWAGHTVELPCTASGYPIP-AIRWLKDGRPLPAD 329
Query: 3067 VHISPNGSIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKV 3126
+ + +TI R + GTY C +N +G A++ L V P V++ P+ + +
Sbjct: 330 SRWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPK-KLKTGI 388
Query: 3127 GKAVTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMD-SHAVLQISSAKPSDAGTYVC 3185
G V L C G P + RW R +T L + S+ L I+SA+ S +G Y C
Sbjct: 389 GSTVILSCALTGSPEFTIRWYR--NTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQC 446
Query: 3186 LAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW 3245
A TAQ + A+ G P++ + +E V G +L C+A G+P PT+ W
Sbjct: 447 FATRKAQTAQDFAII-----ALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTW 501
Query: 3246 SKLRSPL--PWQHRL------EGDTLIIPRVAQ---QDSGQYICNATSPAGHAEATIILH 3294
+ P+ HR +G T+ V +D G Y C A + G AE ++
Sbjct: 502 ALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARIN 561
Query: 3295 VESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLPGRATARNELLHFER 3354
V PP + +V AG + C G P + +W + LP R
Sbjct: 562 VRGPPSIRAMRNITAV-AGRDTLINCRVIGYPYYSIKWYKDALLLPDN----------HR 610
Query: 3355 AAPEDSGRYRCRVTNK-VGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLET--- 3410
++G + K + E +L+Q P SI V+V P ++
Sbjct: 611 QVVFENGTLKLTDVQKGMDEGEYLCSVLIQ------PQLSISQSVHVAVKVPPLIQPFEF 664
Query: 3411 --KSIGASVEFHCAVPS-DRGTQLRWFKEGGQLPPGHSVQD------GVLRIQNLDQSCQ 3461
SIG + C V S D ++ W K+G + G V L+I ++
Sbjct: 665 PPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHN 724
Query: 3462 GTYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKPQVT 3521
G Y C A QL+++ P ++ + + Q + G A C G P P+V
Sbjct: 725 GNYTCIASNAAATVSRERQLIVRVPPRFVV--QPNNQDGIYGKAGVLNCSVDGYPPPKVM 782
Query: 3522 WSKVGGHLRP---------GIVQ--SGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLL 3570
W G P G +Q + I HV D G Y C A+N GT S +
Sbjct: 783 WKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMF 842
Query: 3571 LVQALPQI--SMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE------ 3622
L +P + S P G A C A G I W K D + PD +
Sbjct: 843 LTVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATK 902
Query: 3623 ---NNMLMLPSVRPQDAGTYV---CTATNRQGKVKAFAHLQVPE 3660
+ ++ ++P D G V C A N G+ + L V E
Sbjct: 903 DNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQE 946
Score = 164 bits (414), Expect = 2e-39
Identities = 316/1494 (21%), Positives = 523/1494 (35%), Gaps = 272/1494 (18%)
Query: 1887 CSATGSPTPTLEW---TGGPGGQLPAKAQIHG-GILRLPAVEPT------DQAQYLCRAH 1936
C A GSP+ L W TG +P +H G L+L P+ Y C A
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
Query: 1937 SSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSAT------ITWR 1990
++AG+ + + V V E + G C +PS+ ++W
Sbjct: 167 NAAGK-IRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCL---IPSSVQEYVSVVSWE 222
Query: 1991 KEGGSLPPQARSERTDIATLLIPAITTADA-GFYLCVATSPAGTAQARIQVVVLSASDA- 2048
K+ S+ P+ R T L I + DA Y C+ + LS +D
Sbjct: 223 KDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVTDPA 282
Query: 2049 -SPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPHTQ--VHGSRLRLP 2105
S P + S V G T++L C +G + W + G LP ++ + L +
Sbjct: 283 ESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRITGLTIS 342
Query: 2106 QVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE 2165
+ DSG Y+C V N G EA+ + V+ H + + P
Sbjct: 343 DLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH--------------VTLTPKKLKTGI 388
Query: 2166 GQTLDLNCVVPGQAHAQVTWHKR------GGSLPARHQTHGSLLRLHQVTPADSGEYVCH 2219
G T+ L+C + G + W++ ++ R ++ +LL + + SG Y C
Sbjct: 389 GSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-ITSAQKSHSGAYQCF 447
Query: 2220 VVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTW- 2278
+ + ++ +E P + S V G+ L C G VTW
Sbjct: 448 ATRKAQTAQDFAIIALEDGT-----PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWA 502
Query: 2279 -----YKRGGSLPARHQVRG-----SRLYIFQASPADAGQYVCRASNGMEASITVTVTGT 2328
R GS S + + D G Y C A N + G+
Sbjct: 503 LDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARN---------LVGS 553
Query: 2329 QGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQ-- 2386
IR + + VA TL +NC V G + + W+K LP H+
Sbjct: 554 AEYQARINVRGPPSIRAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDALLLPDNHRQV 612
Query: 2387 --THGSLLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESS 2444
+G+L D GEY+C VL + + S+ ++ A VP L + P E
Sbjct: 613 VFENGTLKLTDVQKGMDEGEYLCSVL---IQPQLSISQSVHVAVKVPPL-IQP---FEFP 665
Query: 2445 SSQVAEGQTLDLNCLV-AGQAHAQVTWHK------RGGSLPARHQVHGSRLRLLQVTPAD 2497
+ + GQ L + C+V +G ++TW K G + + S L++ V+
Sbjct: 666 PASI--GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKH 723
Query: 2498 SGEYVCRVVGSSGT--QEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNC 2555
+G Y C ++ T +E ++V + R ++ ++ G LNC
Sbjct: 724 NGNYTCIASNAAATVSRERQLIVRVPPRFV------------VQPNNQDGIYGKAGVLNC 771
Query: 2556 LVASQAPHTITWYKRGGS----------LPSRHQIV-GSRLRIPQVTPADSGEYVCHVSN 2604
V P + W GS L R QI+ S L I V D G Y+C SN
Sbjct: 772 SVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASN 831
Query: 2605 GAGSR-ETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITW 2663
G G+ S+ +T++ +P++ I ++ ++G +LNC + II W
Sbjct: 832 GVGTDISKSMFLTVK------IPAM---ITSHPNTTIAIKGHAKELNCTARGERPIIIRW 882
Query: 2664 YKRGGSL-PSRHQTHG-----------SHLRLHQMSVADSGEYVCRANNNIDALEASIVI 2711
K + P R + S L+L DS + C A N+ I +
Sbjct: 883 EKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQL 942
Query: 2712 SVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSHH 2771
+V P P +++ S ++ + D N ++ G + + + S
Sbjct: 943 TVQ----EPPDPPELEIREVKARSMNLRWTQRFDGNSIITG---FDIEYKNKSDSWDFKQ 995
Query: 2772 QTR--------GSRLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAP 2823
TR + + LH S Y +G S P + + T EA AP
Sbjct: 996 STRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEA---------AP 1046
Query: 2824 GGAP-PIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARHQVHGPLLRLNQ 2882
G P + ++P +S+ QVTW L + G + +
Sbjct: 1047 DGPPMDVTLQPVTSQ-----------------SIQVTWKAPKKEL-QNGVIRGYQIGYRE 1088
Query: 2883 VSPADSGEYSCQVTGSSGTLEASVLVTIE------------------PSS---------- 2914
SP +G+YS ++G E L ++ PSS
Sbjct: 1089 NSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLED 1148
Query: 2915 -PGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPG------QAHAQVTWYKRGGSLPA 2967
P P A I + + +E LN V+ G + W +
Sbjct: 1149 VPSQPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQNITTT 1208
Query: 2968 RHQTH------GSQLRLHLVSPADSGE-------YVCRAASGPGPEQEASFTVTVPPSEG 3014
R + + + +++ +G+ Y+ PGP + PS
Sbjct: 1209 RERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPA----GIKAVPSSA 1264
Query: 3015 SSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNV-HISPNG 3073
SS V+S PP+ + + C P E++T ++L + H++
Sbjct: 1265 SSV-----VVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLFYRIAHLNRGQ 1319
Query: 3074 SIITIVGTRPSNHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLP-EGPVWVKVGKAVTL 3132
+ V V S G + V + G ++ G V K V L
Sbjct: 1320 QYLLWVA----------AVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRL 1369
Query: 3133 ECVSAGEPRSSARWTRISSTPA-KLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLAQNAL 3191
C S G+P + +WT+ S A + + L+ ++ L + + K D+G Y C A N
Sbjct: 1370 PCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTG 1429
Query: 3192 GTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHW 3245
G V ++V QV ++ LTV S T + + T+ W
Sbjct: 1430 GFDTIIVNLLV----------QVPPDQPRLTV----------SKTSASSITLTW 1463
Score = 163 bits (412), Expect = 4e-39
Identities = 229/903 (25%), Positives = 341/903 (37%), Gaps = 141/903 (15%)
Query: 1698 CQVSGSPPHYFYW---SREDGRPVP-------SGTQQRHQGSELHFPS-VQPSDAGVYIC 1746
C +GSP W + +D VP +GT Q + S F S + +D Y C
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDND---YFC 163
Query: 1747 TCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLV- 1805
T N S + V +P TV VE+QRS G F C S Y V
Sbjct: 164 TAENAAGKIRS-PNIRVKAVFREPYTVRVEDQRSMR---GNVAVFKCLIPSSVQEYVSVV 219
Query: 1806 -WTRLHNGKLPTRA--MDFNGILTIRNVQLSDA-GTYVCTGSNMFAMD--QGTATLHVQA 1859
W + +P + ++G L I +VQ DA TY C + ++ + Q
Sbjct: 220 SWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARLSVT 279
Query: 1860 SGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGPGGQLPAKAQIHGGI-- 1917
S P + V G E C+A+G P P + W G LPA ++ I
Sbjct: 280 DPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWL-KDGRPLPADSRWTKRITG 338
Query: 1918 LRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLYC 1977
L + + D Y+C ++ G A +L V V ++P++ + G TV L C
Sbjct: 339 LTISDLRTEDSGTYICEVTNTFGSAEATGILMVI--DPLHVTLTPKKLKTGIGSTVILSC 396
Query: 1978 RAAGVPSATITW-RKEGGSLPPQARSER-TDIATLLIPAITTADAGFYLCVATSPAGTAQ 2035
G P TI W R LP +A S R TLLI + + +G Y C AT A TAQ
Sbjct: 397 ALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQ 456
Query: 2036 ARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVTW-------YRRG 2088
+++ D +P V S V G+ L C G+ VTW R G
Sbjct: 457 ---DFAIIALEDGTPRIVS-SFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDG 512
Query: 2089 -----------GSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHG 2137
G+ H V G ++R D G Y C N G E ++V
Sbjct: 513 SHRTNQYTMSDGTTISHMNVTGPQIR-------DGGVYRCTARNLVGSAEYQARINV--- 562
Query: 2138 THSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSLPARHQ 2197
GP IR + + VA TL +NC V G + + W+K LP H+
Sbjct: 563 --RGPP---------SIRAMRNITAVAGRDTL-INCRVIGYPYYSIKWYKDALLLPDNHR 610
Query: 2198 ----THGSLLRLHQVTPADSGEYVCHVV---GTSGPLEASVLVTIEASVIPGPIPPVRIE 2250
+G+L D GEY+C V+ S V V + + P PP I
Sbjct: 611 QVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASI- 669
Query: 2251 SSSSTVAEGQTLDLSCVV-AGQAHAQVTWYK------RGGSLPARHQVRGSRLYIFQASP 2303
GQ L + CVV +G ++TW K G + + S L I S
Sbjct: 670 --------GQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSL 721
Query: 2304 ADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSSSQVAEGQTLDLNCV 2363
G Y C ASN TV+ + + P ++P++ G+ LNC
Sbjct: 722 KHNGNYTCIASNA-----AATVSRERQLIVRVPPRFV----VQPNNQDGIYGKAGVLNCS 772
Query: 2364 VPGQSHAQVTW-HKRGGSLPVRHQ----------THGSLLRLYQASPADSGEYVCRVL-G 2411
V G +V W H +G P ++ S L + D G Y+C+ G
Sbjct: 773 VDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNG 832
Query: 2412 SSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWH 2471
+ S+ +T++ +PA+ + +++ +G +LNC G+ + W
Sbjct: 833 VGTDISKSMFLTVK----IPAM-----ITSHPNTTIAIKGHAKELNCTARGERPIIIRWE 883
Query: 2472 KRGGSL-PARHQVHGSRLR--------LLQVTPADSGEYV---CRVVGSSGTQEASVLVT 2519
K + P R + + L++ PAD G+ V C + S G + +T
Sbjct: 884 KGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLT 943
Query: 2520 IQQ 2522
+Q+
Sbjct: 944 VQE 946
Score = 159 bits (403), Expect = 4e-38
Identities = 322/1484 (21%), Positives = 513/1484 (34%), Gaps = 278/1484 (18%)
Query: 2072 CVVAGSAHAQVTWYRRGGS----LPPHTQVHGS-RLRLPQVSPA------DSGEYVCRVE 2120
C AGS A + WY G +P VH + L+L SP+ +Y C E
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
Query: 2121 NGSGP-KEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQA 2179
N +G + +I V + YT +R+E S G C++P
Sbjct: 167 NAAGKIRSPNIRVKAVFRE----PYT--------VRVEDQRS--MRGNVAVFKCLIPSSV 212
Query: 2180 H---AQVTWHKRGGSLPARHQ---THGSLLRLHQVTPADS-GEYVCHVVGT-SGPLEASV 2231
+ V+W K S+ H+ T+ L + V D+ Y C SG S
Sbjct: 213 QEYVSVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSN 272
Query: 2232 LVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPA--RH 2289
+ + IP + S V G T++L C +G + W K G LPA R
Sbjct: 273 GARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRW 332
Query: 2290 QVRGSRLYIFQASPADAGQYVCRASNGMEASITVTVTGTQGANLAYPAGSTQPIRIEPSS 2349
R + L I D+G Y+C +N G+ A + + P
Sbjct: 333 TKRITGLTISDLRTEDSGTYICEVTNTF---------GSAEATGILMVIDPLHVTLTPKK 383
Query: 2350 SQVAEGQTLDLNCVVPGQSHAQVTWHKR------GGSLPVRHQTHGSLLRLYQASPADSG 2403
+ G T+ L+C + G + W++ ++ +R ++ +LL + A + SG
Sbjct: 384 LKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLL-ITSAQKSHSG 442
Query: 2404 EYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQ 2463
Y C + + ++ +E TP + S V G+ L C G
Sbjct: 443 AYQCFATRKAQTAQDFAIIALEDG--------TPRIVSSFSEKVVNPGEQFSLMCAAKGA 494
Query: 2464 AHAQVTWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQR 2523
VTW +L V R Q T +D V ++ V +
Sbjct: 495 PPPTVTW-----ALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARN 549
Query: 2524 LSGSHSQGVAYPVRIESSSASLAN-----GHTLDLNCLVASQAPHTITWYKRGGSLPSRH 2578
L GS VR S ++ N G +NC V ++I WYK LP H
Sbjct: 550 LVGSAEYQARINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPDNH 609
Query: 2579 QIV---GSRLRIPQVTPA-DSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRI 2634
+ V L++ V D GEY+C V + + S S HV PP+
Sbjct: 610 RQVVFENGTLKLTDVQKGMDEGEYLCSVL---------IQPQLSISQSVHVAVKVPPLIQ 660
Query: 2635 ESSSPTVVEGQTLDLNCVVARQPQAI-ITWYKRGGSLPS------RHQTHGSHLRLHQMS 2687
P GQ L + CVV+ I ITW K G + S + S L++ +S
Sbjct: 661 PFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVS 720
Query: 2688 VADSGEYVCRANNNIDAL--EASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLD 2745
+ +G Y C A+N + E +++ V P ++ ++ G+
Sbjct: 721 LKHNGNYTCIASNAAATVSRERQLIVRVPPR------------FVVQPNNQDGIYGKAGV 768
Query: 2746 LNCVVPGQAHAQVTW-HKRGGSLPSHHQT----------RGSRLRLHHVSPADSGEYVCR 2794
LNC V G +V W H +G P + S L + HV D G Y+C+
Sbjct: 769 LNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQ 828
Query: 2795 VMGSSGP-LEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQ 2853
G + S+ +T++ +PA I P+++ +G +L C G+
Sbjct: 829 ASNGVGTDISKSMFLTVK--------IPAM-----ITSHPNTTIAIKGHAKELNCTARGE 875
Query: 2854 AHAQVTWHKRGGNL-PARHQVHGPLLRLN--------QVSPADSGE---YSCQVTGSSGT 2901
+ W K + P R + + N ++ PAD G+ +SC S G
Sbjct: 876 RPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGE 935
Query: 2902 LEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKR 2961
+ +T++ P P + ++A S ++ Q D N ++ G + + +
Sbjct: 936 DRGLIQLTVQEP-----PDPPELEIREVKARSMNLRWTQRFDGNSIITG---FDIEYKNK 987
Query: 2962 GGSLPARHQTHGSQ--------LRLHLVSPADSGEYVCRAASGPGPEQEASFTVTVPPSE 3013
S + T + LH S Y P +E + + +
Sbjct: 988 SDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAAPD 1047
Query: 3014 GSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPNG 3073
G P T+Q S I + WK +EL++ V G
Sbjct: 1048 GP------------PMDVTLQPVTSQS-----------IQVTWKAPKKELQNGVI---RG 1081
Query: 3074 SIITIVGTRPSNHGTYRCVASNA-----------------YGVAQSVVNLSVHGPPTVSV 3116
I P ++G Y V A YGV N + GP + +
Sbjct: 1082 YQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEI 1141
Query: 3117 LPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPAKLE------QRTYGLMDSHAVL 3170
A TLE V + +P + R I+S A + G++ + V+
Sbjct: 1142 -----------NATTLEDVPS-QPPENVRALSITSDVAVISWSEPPRSTLNGVLKGYRVI 1189
Query: 3171 QISSAKPSDAG-----------------------TYVCLAQNALGTAQKQVEVIVDTGAM 3207
S + G + LA G + + + T
Sbjct: 1190 FWSLYVDGEWGEMQNITTTRERVELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKED 1249
Query: 3208 APGAPQ----VQAEEAELTVE---------AGHTATLRCSATGS--PAPTIHWS---KLR 3249
PG P V + + + V T+ CS+ GS PAP+ + + +L
Sbjct: 1250 VPGPPAGIKAVPSSASSVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEYETSPEQLF 1309
Query: 3250 SPLPWQHRLEGDTLIIPRVAQQDSGQYICNAT-SPAGHAEATIILHVESPPYATTVPEHA 3308
+ +R + L + V G T PAG A A II + TV
Sbjct: 1310 YRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKII------SFGGTV---- 1359
Query: 3309 SVQAGETVQLQCLAHGTPPLTFQWSR------VGSSLPG-RATARNELLHFERAAPEDSG 3361
+ + V+L C + G P +W++ + S+ G R N L EDSG
Sbjct: 1360 TTPWMKDVRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSG 1419
Query: 3362 RYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVT 3405
Y C TN G LLVQ PP P ++ S ++ +T
Sbjct: 1420 YYTCTATNTGGFDTIIVNLLVQVPPDQ-PRLTVSKTSASSITLT 1462
Score = 147 bits (370), Expect = 3e-34
Identities = 168/624 (26%), Positives = 241/624 (38%), Gaps = 70/624 (11%)
Query: 3089 YRCVASNAYGVAQSV---VNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSAR 3145
Y C A NA G +S V P TV V + + V L S E S
Sbjct: 161 YFCTAENAAGKIRSPNIRVKAVFREPYTVRVEDQRSMRGNVAVFKCLIPSSVQEYVSVVS 220
Query: 3146 WTR--ISSTPAKLEQRTYGLMDSHAVLQISSAKPSDA-GTYVCLAQNAL-GTAQKQVEVI 3201
W + +S P TY H L IS + DA TY C+ ++ G ++
Sbjct: 221 WEKDTVSIIPEHRFFITY-----HGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGAR 275
Query: 3202 VDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPLP----WQHR 3257
+ A P + V AGHT L C+A+G P P I W K PLP W R
Sbjct: 276 LSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKR 335
Query: 3258 LEGDTLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQ 3317
+ G L I + +DSG YIC T+ G AEAT IL V P + T P+ G TV
Sbjct: 336 ITG--LTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLHVTLTPKKLKTGIGSTVI 393
Query: 3318 LQCLAHGTPPLTFQWSR-VGSSLPGRATA----RNELLHFERAAPEDSGRYRCRVTNKVG 3372
L C G+P T +W R LP A + NE L A SG Y+C T K
Sbjct: 394 LSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQ 453
Query: 3373 SAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLR 3432
+A+ FA + ++ TP + + + + G CA +
Sbjct: 454 TAQDFAIIALE-------------DGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVT 500
Query: 3433 W-------FKEGGQLPPGHSVQDGV----LRIQNLDQSCQGTYICQAHGPWGKAQASAQL 3481
W ++G +++ DG + + G Y C A G A+ A++
Sbjct: 501 WALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTARNLVGSAEYQARI 560
Query: 3482 VIQALPSV--LINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGHLRPG----IVQ 3535
++ PS+ + NI T V G C +G P + W K L P +V
Sbjct: 561 NVRGPPSIRAMRNI-----TAVAGRDTLINCRVIGYPYYSIKWYK-DALLLPDNHRQVVF 614
Query: 3536 SGGVVRIAHVELA-DAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEV-RVPAGSAAV 3593
G +++ V+ D G+Y C+ + S + + +P + P E G
Sbjct: 615 ENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQPFEFPPASIGQLLY 674
Query: 3594 FPCIASGYPTP-DISWSK-----LDGS-LPPDSRLENNMLMLPSVRPQDAGTYVCTATNR 3646
PC+ S P I+W K + GS + +S+ + L + SV + G Y C A+N
Sbjct: 675 IPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNA 734
Query: 3647 QGKVKAFAHLQVPERVVPYFTQTP 3670
V L V RV P F P
Sbjct: 735 AATVSRERQLIV--RVPPRFVVQP 756
Score = 142 bits (357), Expect = 1e-32
Identities = 170/643 (26%), Positives = 254/643 (39%), Gaps = 88/643 (13%)
Query: 3130 VTLECVSAGEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGT------Y 3183
V + C +AG P ++ RW +++ + + ++ LQ+ PS + Y
Sbjct: 103 VVVPCPAAGSPSAALRW-YLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDY 161
Query: 3184 VCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRC---SATGSPA 3240
C A+NA G + + V P +V+ + + G+ A +C S+
Sbjct: 162 FCTAENAAGKI-RSPNIRVKAVFREPYTVRVEDQRS----MRGNVAVFKCLIPSSVQEYV 216
Query: 3241 PTIHWSKLRSPLPWQHRL---EGDTLIIPRVAQQDS-GQYIC-------NATSPAGHAEA 3289
+ W K + +HR L I V ++D+ Y C T + A
Sbjct: 217 SVVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGETRQSNGARL 276
Query: 3290 TIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSSLP--GRATARN 3347
++ ES P V AG TV+L C A G P +W + G LP R T R
Sbjct: 277 SVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRI 336
Query: 3348 ELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQ 3407
L EDSG Y C VTN GSAEA L+V P V +TP+
Sbjct: 337 TGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDP--------------LHVTLTPK 382
Query: 3408 LETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHSV-----QDGVLRIQNLDQSCQG 3462
IG++V CA+ +RW++ + P ++ + L I + +S G
Sbjct: 383 KLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQKSHSG 442
Query: 3463 TYICQAHGPWGKAQASAQLVIQALPSVLINIRTSVQTVVVGHAVEFE--CLALGDPKPQV 3520
Y C A KAQ + I AL I +S VV +F C A G P P V
Sbjct: 443 AYQCFA---TRKAQTAQDFAIIALEDGTPRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTV 499
Query: 3521 TWS-------KVGGHLRPGIVQSGGVVRIAHV-----ELADAGQYRCTATNAAGTTQSHV 3568
TW+ + G H S G I+H+ ++ D G YRCTA N G+ +
Sbjct: 500 TWALDDEPIVRDGSHRTNQYTMSDGTT-ISHMNVTGPQIRDGGVYRCTARNLVGSAEYQA 558
Query: 3569 LLLVQALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSR----LENN 3624
+ V+ P I + + AG + C GYP I W K D L PD+ EN
Sbjct: 559 RINVRGPPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYK-DALLLPDNHRQVVFENG 617
Query: 3625 MLMLPSV-RPQDAGTYVCTA-TNRQGKVKAFAH--LQVPERVVPYFTQTPYS---FLPLP 3677
L L V + D G Y+C+ Q + H ++VP + P F P S L +P
Sbjct: 618 TLKLTDVQKGMDEGEYLCSVLIQPQLSISQSVHVAVKVPPLIQP-FEFPPASIGQLLYIP 676
Query: 3678 TIKDAYRKFEIKITFRPDSADGMLLYNGQKRVPGSPTNLANRQ 3720
+ + I+IT+R D GQ + GS + +++
Sbjct: 677 CVVSS-GDMPIRITWRKD---------GQVIISGSGVTIESKE 709
Score = 141 bits (356), Expect = 1e-32
Identities = 203/894 (22%), Positives = 340/894 (38%), Gaps = 137/894 (15%)
Query: 1691 GGSHSLRCQVSGSPPHYFYWSREDGRPVPSGTQQRHQGSELHFPSVQPSDAGVYICTCRN 1750
G + L C SG P W + DGRP+P+ ++ + + L ++ D+G YIC N
Sbjct: 300 GHTVELPCTASGYPIPAIRWLK-DGRPLPADSRWTKRITGLTISDLRTEDSGTYICEVTN 358
Query: 1751 LHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFICTAKSKSPAYTLVWTRLH 1810
S + L+V + P+ VT+ ++ ++ G+ V C A + SP +T+ W R
Sbjct: 359 TFGSAEATGILMVID----PLHVTLTPKKLKT-GIGSTVILSC-ALTGSPEFTIRWYRNT 412
Query: 1811 NGKLPTRAMDFNGI----LTIRNVQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAP 1866
LP A+ G+ L I + Q S +G Y C + Q A + ++ GT P
Sbjct: 413 ELVLPDEAISIRGLSNETLLITSAQKSHSGAYQCFATRKAQTAQDFAIIALE-DGT---P 468
Query: 1867 VVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWT------GGPGGQLPAKAQIHGGI--- 1917
+ + V PG+ C+A G+P PT+ W G + + G
Sbjct: 469 RIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTIS 528
Query: 1918 -LRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQVHAGRTVRLY 1976
+ + + D Y C A + G +A ++V G P ++ T V AGR +
Sbjct: 529 HMNVTGPQIRDGGVYRCTARNLVGSAEYQARINVR--GPPSIRAMRNITAV-AGRDTLIN 585
Query: 1977 CRAAGVPSATITWRKEGGSLPPQARSERTDIATLLIPAITTA-DAGFYLC-VATSPAGTA 2034
CR G P +I W K+ LP R + TL + + D G YLC V P +
Sbjct: 586 CRVIGYPYYSIKWYKDALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSI 645
Query: 2035 QARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVV-AGSAHAQVTWYR------R 2087
+ V V PP+ P + GQ L + CVV +G ++TW +
Sbjct: 646 SQSVHVAV------KVPPLIQPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIIS 699
Query: 2088 GGSLPPHTQVHGSRLRLPQVSPADSGEYVCRVENGSG--PKEASITVSVLHGTHSGPSYT 2145
G + ++ S L++ VS +G Y C N + +E + V V P +
Sbjct: 700 GSGVTIESKEFMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRV------PPRFV 753
Query: 2146 PVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTW-HKRGGSLPARHQ------- 2197
++P++ G+ LNC V G +V W H +G P ++
Sbjct: 754 ----------VQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGR 803
Query: 2198 ---THGSLLRLHQVTPADSGEYVCHVV-GTSGPLEASVLVTIEASVIPGPIPPVRIESSS 2253
S L + V D G Y+C G + S+ +T++ IP + +
Sbjct: 804 IQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDISKSMFLTVK-------IPAMITSHPN 856
Query: 2254 STVA-EGQTLDLSCVVAGQAHAQVTWYKRGGSLPARHQVR---------GSRLYIFQASP 2303
+T+A +G +L+C G+ + W K + +R + + P
Sbjct: 857 TTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKP 916
Query: 2304 ADAGQYV---CRASNGM---EASITVTVTGTQGANLAYPAGSTQPIR-IEPSSSQVAEGQ 2356
AD G V C A N I +TV P IR ++ S + Q
Sbjct: 917 ADRGDSVFFSCHAINSYGEDRGLIQLTVQEP-------PDPPELEIREVKARSMNLRWTQ 969
Query: 2357 TLDLNCVVPGQSHAQVTWHKRGGSLPVRHQT--------HGSLLRLYQASPADSGEYVCR 2408
D N ++ G + + + S + T +++ L+ AS Y
Sbjct: 970 RFDGNSIITG---FDIEYKNKSDSWDFKQSTRNISPTINQANIVDLHPASVYSIRMYSFN 1026
Query: 2409 VLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAGQAHAQV 2468
+G S P + + T E A P + VT ++ +SQ QV
Sbjct: 1027 KIGRSEPSKELTISTEEAAPDGPPMDVT----LQPVTSQ-----------------SIQV 1065
Query: 2469 TWHKRGGSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQ 2522
TW L + G ++ + +P +G+Y + ++G E L +++
Sbjct: 1066 TWKAPKKEL-QNGVIRGYQIGYRENSPGSNGQYSIVEMKATGDSEVYTLDNLKK 1118
Score = 128 bits (321), Expect = 1e-28
Identities = 199/904 (22%), Positives = 320/904 (35%), Gaps = 129/904 (14%)
Query: 2651 CVVARQPQAIITWYKRGGS----LPS-RHQTHGSHLRLHQMSVA------DSGEYVCRAN 2699
C A P A + WY G +P RH L+L+ S + +Y C A
Sbjct: 107 CPAAGSPSAALRWYLATGDDIYDVPHIRHVHANGTLQLYPFSPSAFNSFIHDNDYFCTAE 166
Query: 2700 NNIDALEASIVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAH---A 2756
N + SP+ + +R+E S G C++P +
Sbjct: 167 NAAGKIR-------SPNIRVKAVFREPYTVRVEDQRS--MRGNVAVFKCLIPSSVQEYVS 217
Query: 2757 QVTWHKRGGSLPSHHQ---TRGSRLRLHHVSPADS-GEYVCRVMGS-SGPLEASVLVTIE 2811
V+W K S+ H+ T L + V D+ Y C SG T +
Sbjct: 218 VVSWEKDTVSIIPEHRFFITYHGGLYISDVQKEDALSTYRCITKHKYSGE-------TRQ 270
Query: 2812 ASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPARH 2871
++G+ P I S V G T++L C G + W K G LPA
Sbjct: 271 SNGARLSVTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADS 330
Query: 2872 QVHGPL--LRLNQVSPADSGEYSCQVTGSSGTLEAS-VLVTIEPSSPGPIPAPGLAQPIY 2928
+ + L ++ + DSG Y C+VT + G+ EA+ +L+ I+P +
Sbjct: 331 RWTKRITGLTISDLRTEDSGTYICEVTNTFGSAEATGILMVIDPLH------------VT 378
Query: 2929 IEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGGS-LPARH-QTHGSQLRLHLVSPAD- 2985
+ G T+ L+C + G + WY+ LP G L++ A
Sbjct: 379 LTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLITSAQK 438
Query: 2986 --SGEYVCRAASGPGPEQEASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKC 3043
SG Y C A Q A + +G+ P I V G+ S C
Sbjct: 439 SHSGAYQCFATR---KAQTAQDFAIIALEDGT------PRIVSSFSEKVVNPGEQFSLMC 489
Query: 3044 LIHDGAAPISLEWKTRNQEL------EDNVHISPNGSIIT---IVGTRPSNHGTYRCVAS 3094
GA P ++ W ++ + N + +G+ I+ + G + + G YRC A
Sbjct: 490 AAK-GAPPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR 548
Query: 3095 NAYGVAQSVVNLSVHGPPTVSVLPEGPVWVKVGKAVTLECVSAGEPRSSARWTRISSTPA 3154
N G A+ ++V GPP++ + + G+ + C G P S +W +
Sbjct: 549 NLVGSAEYQARINVRGPPSIRAMRN--ITAVAGRDTLINCRVIGYPYYSIKWYK---DAL 603
Query: 3155 KLEQRTYGLMDSHAVLQISSA-KPSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQ 3213
L ++ + L+++ K D G Y+C + L Q + V P P
Sbjct: 604 LLPDNHRQVVFENGTLKLTDVQKGMDEGEYLC---SVLIQPQLSISQSVHVAVKVP--PL 658
Query: 3214 VQAEEAELTVEAGHTATLRCSATGSPAP-TIHWSK------LRSPLPWQHRLEGDTLIIP 3266
+Q E G + C + P I W K S + + + +L I
Sbjct: 659 IQPFEFP-PASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQIS 717
Query: 3267 RVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVPEHASVQAGETVQLQCLAHGTP 3326
V+ + +G Y C A++ A L V PP P + G+ L C G P
Sbjct: 718 SVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNCSVDGYP 777
Query: 3327 PLTFQWSRVGSS----------LPGR-ATARNELLHFERAAPEDSGRYRCRVTNKVGSAE 3375
P W S L GR N L ED G Y C+ +N VG+
Sbjct: 778 PPKVMWKHAKGSGNPQQYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGVGTDI 837
Query: 3376 AFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFK 3435
+ + L IPA T T ++ G + E +C +R +RW K
Sbjct: 838 SKSMFL---------TVKIPAMITSHPNTTIAIK----GHAKELNCTARGERPIIIRWEK 884
Query: 3436 EGGQLPPGHSVQDGV------------LRIQNLDQSCQGTYICQAHGPWGKAQASAQLVI 3483
+ P ++ + L+++ D+ + C A +G+ + QL +
Sbjct: 885 GDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTV 944
Query: 3484 QALP 3487
Q P
Sbjct: 945 QEPP 948
Score = 117 bits (294), Expect = 2e-25
Identities = 245/1157 (21%), Positives = 418/1157 (36%), Gaps = 203/1157 (17%)
Query: 1676 PLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSREDGRPVP-SGTQQRHQGSE-LHF 1733
PL V + P + G + L C ++GSP W R +P R +E L
Sbjct: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNETLLI 433
Query: 1734 PSVQPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTVEEQRSQSVRPGADVTFIC 1793
S Q S +G Y C Q+ A + + + + ++ E + V PG + +C
Sbjct: 434 TSAQKSHSGAYQCFATRKAQTAQDFAIIALEDGTPRIVSSFSE----KVVNPGEQFSLMC 489
Query: 1794 TAKSKSPAYTLVWTR-----LHNGKLPTRAMDFNGILTIRNV-----QLSDAGTYVCTGS 1843
AK +P T+ W + +G T + TI ++ Q+ D G Y CT
Sbjct: 490 AAKG-APPPTVTWALDDEPIVRDGSHRTNQYTMSDGTTISHMNVTGPQIRDGGVYRCTAR 548
Query: 1844 NMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGGP 1903
N+ + A ++V+ ++ A +T G+ C G P +++W
Sbjct: 549 NLVGSAEYQARINVRGPPSIRA------MRNITAVAGRDTLINCRVIGYPYYSIKWY-KD 601
Query: 1904 GGQLP---AKAQIHGGILRLPAVEP-TDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQ 1959
LP + G L+L V+ D+ +YLC ++++V HV P +Q
Sbjct: 602 ALLLPDNHRQVVFENGTLKLTDVQKGMDEGEYLCSVLIQPQLSISQSV-HVAVKVPPLIQ 660
Query: 1960 VSPERTQVHAGRTVRLYC-RAAGVPSATITWRKEGGSLPPQAR---SERTDIATLLIPAI 2015
E G+ + + C ++G ITWRK+G + + + +++L I ++
Sbjct: 661 PF-EFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMSSLQISSV 719
Query: 2016 TTADAGFYLCVATSPAGTAQARIQVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVA 2075
+ G Y C+A++ A T Q++V PP ++ ++ G+ LNC V
Sbjct: 720 SLKHNGNYTCIASNAAATVSRERQLIV-----RVPPRFVVQPNNQDGIYGKAGVLNCSVD 774
Query: 2076 GSAHAQVTWYRRGGSLPPHTQVH------------GSRLRLPQVSPADSGEYVCRVENGS 2123
G +V W GS P Q H S L + V D G Y+C+ NG
Sbjct: 775 GYPPPKVMWKHAKGSGNPQ-QYHPVPLTGRIQILPNSSLLIRHVLEEDIGYYLCQASNGV 833
Query: 2124 G---PKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAH 2180
G K +TV + I P+++ +G +LNC G+
Sbjct: 834 GTDISKSMFLTVKI----------------PAMITSHPNTTIAIKGHAKELNCTARGERP 877
Query: 2181 AQVTWHKRGGSLP---------ARHQTHGSLLRLHQVTPADSGEYV---CHVVGTSGPLE 2228
+ W K + A ++ ++ PAD G+ V CH + + G
Sbjct: 878 IIIRWEKGDTVIDPDRVMRYAIATKDNGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDR 937
Query: 2229 ASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR 2288
+ +T++ P + +++ S + Q D + ++ G + + + S +
Sbjct: 938 GLIQLTVQEPPDPPELEIREVKARSMNLRWTQRFDGNSIITG---FDIEYKNKSDSWDFK 994
Query: 2289 HQVRGSRLYIFQASPAD---AGQYVCRASN-----GMEASITVTVTGTQGANLAYPAGST 2340
R I QA+ D A Y R + E S +T++ + A P G
Sbjct: 995 QSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGRSEPSKELTISTEEAA----PDGPP 1050
Query: 2341 QPIRIEPSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSLPVRHQTHGSLLRLYQA--- 2397
+ ++P +SQ QVTW P + +G ++R YQ
Sbjct: 1051 MDVTLQPVTSQ-----------------SIQVTW-----KAPKKELQNG-VIRGYQIGYR 1087
Query: 2398 --SPADSGEY---VCRVLG------------------------------SSVPLEASVL- 2421
SP +G+Y + G SS + A+ L
Sbjct: 1088 ENSPGSNGQYSIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGTGPSSSEINATTLE 1147
Query: 2422 -VTIEPAGSVPALGVTPTVRIESSSSQVAEGQTLDLNCLVAG------QAHAQVTWHKRG 2474
V +P +V AL +T V + S S E LN ++ G + W +
Sbjct: 1148 DVPSQPPENVRALSITSDVAVISWS----EPPRSTLNGVLKGYRVIFWSLYVDGEWGEMQ 1203
Query: 2475 GSLPARHQVHGSRLRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAY 2534
R +V LR ++ S + + G + + + + ++ + G + A
Sbjct: 1204 NITTTRERV---ELRGMEKFTNYSVQVLAYTQAGDGVRSSVLYIQTKEDVPGPPAGIKAV 1260
Query: 2535 PVRIESSSASLANGHTLDLNCLVASQAPHTITWYKRGGSLPSRHQIVGSRLRIPQVTPAD 2594
P SSAS ++ ++ L ++ I Y S P Q S + +P
Sbjct: 1261 P-----SSAS-----SVVVSWLPPTKPNGVIRKYTIFCSSPGSGQPAPSEY---ETSPEQ 1307
Query: 2595 SGEYVCHVSNGAGSRETSLIVTIQGSGSSH-----VPSVSPPIRIESSSPTVVEGQTLD- 2648
+ H++ G VT G G+S P+ P +I S TV D
Sbjct: 1308 LFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDV 1367
Query: 2649 -LNCVVARQPQAIITWYK--RGGSLPSRHQTH-----GSHLRLHQMSVADSGEYVCRANN 2700
L C P + W K ++P H L L + DSG Y C A N
Sbjct: 1368 RLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATN 1427
Query: 2701 --NIDALEASIVISVSP 2715
D + ++++ V P
Sbjct: 1428 TGGFDTIIVNLLVQVPP 1444
Score = 53.5 bits (127), Expect = 4e-06
Identities = 55/211 (26%), Positives = 84/211 (39%), Gaps = 32/211 (15%)
Query: 3382 VQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLP 3441
V GPP + A A S V P + + C+ P GQ
Sbjct: 1250 VPGPPAGIKAVPSSASSV-VVSWLPPTKPNGVIRKYTIFCSSPGS-----------GQPA 1297
Query: 3442 PGH---SVQDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQAL---PSVLINIRT 3495
P S + RI +L++ Q A G+ +S ++ I+ P+ +I+
Sbjct: 1298 PSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGG 1357
Query: 3496 SVQTVVVGHAVEFECLALGDPKPQVTWSK----------VGGHLRPGIVQSGGVVRIAHV 3545
+V T + V C ++GDP P V W+K + GH ++ + G + + V
Sbjct: 1358 TVTTPWMKD-VRLPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHR---LIHTNGTLLLRAV 1413
Query: 3546 ELADAGQYRCTATNAAGTTQSHVLLLVQALP 3576
+ D+G Y CTATN G V LLVQ P
Sbjct: 1414 KAEDSGYYTCTATNTGGFDTIIVNLLVQVPP 1444
Score = 45.1 bits (105), Expect = 0.002
Identities = 30/88 (34%), Positives = 36/88 (40%), Gaps = 14/88 (15%)
Query: 409 VTPPRESI----------QASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSE 458
VT P ESI + G TV C A G P P I W + +P+ R T
Sbjct: 278 VTDPAESIPTILDGFHSQEVWAGHTVELPCTASGYPIPAIRWLKDGRPLPADSRWTKRIT 337
Query: 459 GGRGTLIIRDVKESDQGAYTCEAMNARG 486
G L I D++ D G Y CE N G
Sbjct: 338 G----LTISDLRTEDSGTYICEVTNTFG 361
Score = 44.7 bits (104), Expect = 0.002
Identities = 36/120 (30%), Positives = 52/120 (43%), Gaps = 12/120 (10%)
Query: 3541 RIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQ-----ISMPQEVRVPAGSAAVFP 3595
RIAH+ A +AG S + ++ + IS V P P
Sbjct: 1311 RIAHLNRGQQYLLWVAAVTSAGRGNSSEKVTIEPAGKAPAKIISFGGTVTTPWMKDVRLP 1370
Query: 3596 CIASGYPTPDISWSK--LDGSLPPDS---RL--ENNMLMLPSVRPQDAGTYVCTATNRQG 3648
C + G P P + W+K D ++P RL N L+L +V+ +D+G Y CTATN G
Sbjct: 1371 CNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNTGG 1430
Score = 41.6 bits (96), Expect = 0.018
Identities = 25/84 (29%), Positives = 40/84 (47%), Gaps = 9/84 (10%)
Query: 424 VTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGR-----GTLIIRDVKESDQGAYT 478
V C ++G P P + W + + V+ +G R GTL++R VK D G YT
Sbjct: 1367 VRLPCNSVGDPAPAVKWTKD----SEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYT 1422
Query: 479 CEAMNARGMVFGIPDGVLELVPQR 502
C A N G I + ++++ P +
Sbjct: 1423 CTATNTGGFDTIIVNLLVQVPPDQ 1446
Score = 38.5 bits (88), Expect = 0.15
Identities = 36/119 (30%), Positives = 49/119 (41%), Gaps = 3/119 (2%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPI-INWRLNWGHIPSHPRVTVTSEGGRG 462
+PP + P E AS GQ + CV PI I WR + I S VT+ S+
Sbjct: 655 VPPLI--QPFEFPPASIGQLLYIPCVVSSGDMPIRITWRKDGQVIISGSGVTIESKEFMS 712
Query: 463 TLIIRDVKESDQGAYTCEAMNARGMVFGIPDGVLELVPQRGPCPDGHFYLEHSAACLPC 521
+L I V G YTC A NA V ++ + P+ P+ + A L C
Sbjct: 713 SLQISSVSLKHNGNYTCIASNAAATVSRERQLIVRVPPRFVVQPNNQDGIYGKAGVLNC 771
Score = 38.1 bits (87), Expect = 0.19
Identities = 36/124 (29%), Positives = 49/124 (39%), Gaps = 26/124 (20%)
Query: 1788 DVTFICTAKSKSPAYTLVWTR-LHNGKLPT-----RAMDFNGILTIRNVQLSDAGTYVCT 1841
DV C + PA + WT+ + +P R + NG L +R V+ D+G Y CT
Sbjct: 1366 DVRLPCNSVG-DPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCT 1424
Query: 1842 GSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTG 1901
+N D L VQ V P+LTV S T + + TL W
Sbjct: 1425 ATNTGGFDTIIVNLLVQ---------VPPDQPRLTV----------SKTSASSITLTWIP 1465
Query: 1902 GPGG 1905
G G
Sbjct: 1466 GDNG 1469
Score = 35.4 bits (80), Expect = 1.3
Identities = 25/91 (27%), Positives = 36/91 (39%), Gaps = 12/91 (13%)
Query: 404 MPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGH--------IPSHPRVTV 455
+PP+ V P G+ C G P P + W+ G +P R+ +
Sbjct: 748 VPPRFVVQPNNQ-DGIYGKAGVLNCSVDGYPPPKVMWKHAKGSGNPQQYHPVPLTGRIQI 806
Query: 456 TSEGGRGTLIIRDVKESDQGAYTCEAMNARG 486
+L+IR V E D G Y C+A N G
Sbjct: 807 LPNS---SLLIRHVLEEDIGYYLCQASNGVG 834
Score = 35.0 bits (79), Expect = 1.6
Identities = 25/92 (27%), Positives = 40/92 (43%), Gaps = 5/92 (5%)
Query: 1696 LRCQVSGSPPHYFYWSRE-DGRPVP---SGTQQRHQGSELHFPSVQPSDAGVYICTCRNL 1751
L C G P W+++ + +P G + H L +V+ D+G Y CT N
Sbjct: 1369 LPCNSVGDPAPAVKWTKDSEDSAIPVSMDGHRLIHTNGTLLLRAVKAEDSGYYTCTATNT 1428
Query: 1752 HQSNTSRAELLVTEAPSKPITVTVEEQRSQSV 1783
+T LLV P +P +TV + + S+
Sbjct: 1429 GGFDTIIVNLLVQVPPDQP-RLTVSKTSASSI 1459
Score = 33.9 bits (76), Expect = 3.7
Identities = 28/123 (22%), Positives = 50/123 (40%), Gaps = 10/123 (8%)
Query: 1672 TNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSRED-----GRPVPSGTQQRH 1726
T + P ++ HP +I +G + L C G P W + D R + +
Sbjct: 844 TVKIPAMITSHPNTTIAIKGHAKELNCTARGERPIIIRWEKGDTVIDPDRVMRYAIATKD 903
Query: 1727 QGSE-LHFPSVQPSDAG---VYICTCRNLHQSNTSRAELLVTEAPSKP-ITVTVEEQRSQ 1781
G E + ++P+D G + C N + + +L V E P P + + + RS
Sbjct: 904 NGDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQLTVQEPPDPPELEIREVKARSM 963
Query: 1782 SVR 1784
++R
Sbjct: 964 NLR 966
Score = 33.5 bits (75), Expect = 4.8
Identities = 21/76 (27%), Positives = 32/76 (42%), Gaps = 1/76 (1%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P VT + ++ G TV +C G P I W N + +++ TL+
Sbjct: 374 PLHVTLTPKKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLPDEAISIRGLSNE-TLL 432
Query: 466 IRDVKESDQGAYTCEA 481
I ++S GAY C A
Sbjct: 433 ITSAQKSHSGAYQCFA 448
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 170 bits (431), Expect = 3e-41
Identities = 149/500 (29%), Positives = 212/500 (42%), Gaps = 66/500 (13%)
Query: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL------PWQHR--LEGDTL 3263
P++ ++L V G ATL C A G P PTI W K + P HR L +L
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 3264 IIPRV-----AQQDSGQYICNATSPAGHA---EATIILHVESPPYATTVPEHASVQAGET 3315
R+ ++ D G Y+C A + G A A++ + + + P V GE
Sbjct: 89 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN-PSDVMVAVGEP 147
Query: 3316 VQLQCLA-HGTPPLTFQWSRVGSSLPG---RATARNELLHFERAAPEDSGRYRCRVTNKV 3371
++C G P T W + GS L R T R L D+G+Y C TN V
Sbjct: 148 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 207
Query: 3372 GSAEA-FAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQ 3430
G E+ A+L V P + S + VT + S EF C D
Sbjct: 208 GERESEVAELTVLERPSFVKRPS-------NLAVT-------VDDSAEFKCEARGDPVPT 253
Query: 3431 LRWFKEGGQLPPGHSV--QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
+RW K+ G+LP D L+I+ + G+Y C A GKA+ASA L +Q P
Sbjct: 254 VRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH 313
Query: 3489 VLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGH------------LRPGIVQS 3536
++ R Q V +G V F+C A G+P+P + W + G R + Q+
Sbjct: 314 FVVKPRD--QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
Query: 3537 GGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVR-------VPAG 3589
G + I +V+ +D G Y C N AG+ + L V + P +R V
Sbjct: 372 GDLT-ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 430
Query: 3590 SAAVFPCIASGYPTPDISWSKLDGSL--PPDSR---LENNMLMLPSVRPQDAGTYVCTAT 3644
V C+A+G P P I W K DG L DSR LEN +L + + D G Y C A+
Sbjct: 431 GTFVLSCVATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 489
Query: 3645 NRQGKVKAFAHLQVPERVVP 3664
G+ A+++V E VP
Sbjct: 490 TPSGEATWSAYIEVQEFGVP 509
Score = 142 bits (359), Expect = 6e-33
Identities = 139/505 (27%), Positives = 203/505 (40%), Gaps = 53/505 (10%)
Query: 3015 SSYRLRS----PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH-- 3068
S RLR P I P V +G+ A+ C P ++EW + +E +
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTP-TIEWYKGGERVETDKDDP 76
Query: 3069 -----ISPNGSI--ITIVGTRPS--NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPE 3119
+ P+GS+ + IV R S + G Y CVA N G A S N S+ +
Sbjct: 77 RSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH-NASLEVAILRDDFRQ 135
Query: 3120 GP--VWVKVGKAVTLECVSA-GEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAK 3176
P V V VG+ +EC G P + W + S L+ + + L I+ +
Sbjct: 136 NPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTR 192
Query: 3177 PSDAGTYVCLAQNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSAT 3236
SDAG YVC+ N +G + +V + P + L V +A +C A
Sbjct: 193 KSDAGKYVCVGTNMVGERESEVAELT-----VLERPSFVKRPSNLAVTVDDSAEFKCEAR 247
Query: 3237 GSPAPTIHWSKLRSPLPW-QHRLEGD-TLIIPRVAQQDSGQYICNATSPAGHAEATIILH 3294
G P PT+ W K LP ++ + D TL I +V D G Y C A + G AEA+ L
Sbjct: 248 GDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLT 307
Query: 3295 VESPPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSS------LPGRATARNE 3348
V+ PP+ P V G TV QC A G P W R GS P ++++R
Sbjct: 308 VQEPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFS 367
Query: 3349 L-----LHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQ 3403
+ L D G Y C+ N GS A L V P P ++
Sbjct: 368 VSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP--------PPVIR 419
Query: 3404 VTPQLETKSIGASVEFHCAVPSDRGTQLRWFKEGGQLPPGHS----VQDGVLRIQNLDQS 3459
P +T ++ + C + W K+G + S +++GVL+I+
Sbjct: 420 QGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLG 479
Query: 3460 CQGTYICQAHGPWGKAQASAQLVIQ 3484
G Y C A P G+A SA + +Q
Sbjct: 480 DTGRYTCIASTPSGEATWSAYIEVQ 504
Score = 142 bits (358), Expect = 7e-33
Identities = 139/530 (26%), Positives = 198/530 (37%), Gaps = 46/530 (8%)
Query: 1666 GQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSR-----EDGRPVPS 1720
G L + + P +VE HP+ IV +G +L C+ G P W + E + P
Sbjct: 19 GSRLRQEDFPPRIVE-HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 1721 GTQQRHQGSELHFPSV-----QPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTV 1775
+ L F + D GVY+C RN V+ S + +
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE-------AVSHNASLEVAILR 130
Query: 1776 EEQRSQS----VRPGADVTFICTAKSKSPAYTLVWTRLHN--GKLPTRAMDFNGILTIRN 1829
++ R V G C P T+ W + + R G L I
Sbjct: 131 DDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY 190
Query: 1830 VQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSA 1889
+ SDAG YVC G+NM G V L P P L V AEF+C A
Sbjct: 191 TRKSDAGKYVCVGTNMV----GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEA 246
Query: 1890 TGSPTPTLEWTGGPGGQLPAKAQIHGG-ILRLPAVEPTDQAQYLCRAHSSAGQQVARAVL 1948
G P PT+ W G ++ +I L++ V D Y C A + G+ A A L
Sbjct: 247 RGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL 306
Query: 1949 HVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGS------LPPQARS 2002
V P V P V GRTV C A G P I WR+EG PPQ+ S
Sbjct: 307 TVQ--EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 364
Query: 2003 ERTDIAT--LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSA-SDASPPPVKIESSS 2059
+ T L I + +D G+Y+C + AG+ + + V +D PP ++ +
Sbjct: 365 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 424
Query: 2060 PSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPH----TQVHGSRLRLPQVSPADSGEY 2115
+V T L+CV GS + W + G + Q+ L++ D+G Y
Sbjct: 425 QTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 484
Query: 2116 VCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE 2165
C SG EA+ + + P P P I PS V +
Sbjct: 485 TCIASTPSG--EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD 532
Score = 140 bits (353), Expect = 3e-32
Identities = 125/488 (25%), Positives = 187/488 (38%), Gaps = 66/488 (13%)
Query: 1866 PVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGG------------------PGGQL 1907
P + HP L V G+ A C A G PTPT+EW G P G L
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 1908 PAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQV 1967
+HG R D+ Y+C A + G+ V+ + +P V
Sbjct: 89 FFLRIVHGRKSR------PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 142
Query: 1968 HAGRTVRLYCRAA-GVPSATITWRKEGGSLPPQARSERTDI--ATLLIPAITTADAGFYL 2024
G + C+ G P TI+W+K+G P + ER I L+I +DAG Y+
Sbjct: 143 AVGEPAVMECQPPRGHPEPTISWKKDGS--PLDDKDERITIRGGKLMITYTRKSDAGKYV 200
Query: 2025 CVATSPAGTAQARI-QVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2083
CV T+ G ++ + ++ VL P S+ +VT + + C G V
Sbjct: 201 CVGTNMVGERESEVAELTVLERPSFVKRP-----SNLAVTVDDSAEFKCEARGDPVPTVR 255
Query: 2084 WYRRGGSLPPHTQV--HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSG 2141
W + G LP L++ +V+ D G Y C EN G EAS T++V H
Sbjct: 256 WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH-- 313
Query: 2142 PSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGS------LPAR 2195
++P VA G+T+ C G + W + G P +
Sbjct: 314 ------------FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 361
Query: 2196 HQTHGSL-----LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIE 2250
+ S+ L + V +D G Y+C + +G + + + + P P +R
Sbjct: 362 SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 421
Query: 2251 SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR----HQVRGSRLYIFQASPADA 2306
+ TVA T LSCV G + W K G + + Q+ L I A D
Sbjct: 422 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 481
Query: 2307 GQYVCRAS 2314
G+Y C AS
Sbjct: 482 GRYTCIAS 489
Score = 120 bits (300), Expect = 4e-26
Identities = 132/562 (23%), Positives = 207/562 (36%), Gaps = 96/562 (17%)
Query: 2437 PTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG-------------------GSL 2477
P + S V++G+ LNC G+ + W+K G GSL
Sbjct: 29 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 88
Query: 2478 PARHQVHGSRLRLLQVTPADSGEYVC---RVVGSSGTQEASVLVTIQQRLSGSHSQGVAY 2534
VHG + R D G YVC +G + + AS+ V I +
Sbjct: 89 FFLRIVHGRKSR------PDEGVYVCVARNYLGEAVSHNASLEVAI-----------LRD 131
Query: 2535 PVRIESSSASLANGHTLDLNCLVASQAPH-TITWYKRGGSLPSRHQ---IVGSRLRIPQV 2590
R S +A G + C P TI+W K G L + + I G +L I
Sbjct: 132 DFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 191
Query: 2591 TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLN 2650
+D+G+YVC +N G RE+ + S V S+ V + +
Sbjct: 192 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK--------RPSNLAVTVDDSAEFK 243
Query: 2651 CVVARQPQAIITWYKRGGSLP-SRHQTHGSH-LRLHQMSVADSGEYVCRANNNIDALEAS 2708
C P + W K G LP SR++ H L++ +++ D G Y C A N + EAS
Sbjct: 244 CEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 303
Query: 2709 IVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGS-- 2766
++V P + VA G T+ C G + W + G
Sbjct: 304 ATLTVQEPPHFVVKPRDQV----------VALGRTVTFQCEATGNPQPAIFWRREGSQNL 353
Query: 2767 ----LPSHHQTRGS-----RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSA 2817
P +R S L + +V +D G Y+C+ + +G + + +
Sbjct: 354 LFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV------- 406
Query: 2818 VHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPAR----HQV 2873
V A P IR P + VA T L CV G + W K G + + Q+
Sbjct: 407 TDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 466
Query: 2874 HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE----------PSSPGPIPAPGL 2923
+L++ D+G Y+C + SG S + ++ P+ P IP+
Sbjct: 467 ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS-AP 525
Query: 2924 AQPIYIEASSSHVTEGQTLDLN 2945
++P + S + VT +LN
Sbjct: 526 SKPEVTDVSRNTVTLSWQPNLN 547
Score = 115 bits (288), Expect = 1e-24
Identities = 130/532 (24%), Positives = 200/532 (37%), Gaps = 72/532 (13%)
Query: 2347 PSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL------PVRHQT---HGSLLRLY-- 2395
PS V++G+ LNC G+ + W+K G + P H+ GSL L
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
Query: 2396 --QASPADSGEYVC---RVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAE 2450
+ S D G YVC LG +V AS+ V I + R S VA
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI----------LRDDFRQNPSDVMVAV 144
Query: 2451 GQTLDLNCLVA-GQAHAQVTWHKRGGSLPARHQ---VHGSRLRLLQVTPADSGEYVCRVV 2506
G+ + C G ++W K G L + + + G +L + +D+G+YVC
Sbjct: 145 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 204
Query: 2507 GSSGTQEASVL-VTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTI 2565
G +E+ V +T+ +R S V P S+ ++ + + C T+
Sbjct: 205 NMVGERESEVAELTVLERPSF-----VKRP-----SNLAVTVDDSAEFKCEARGDPVPTV 254
Query: 2566 TWYKRGGSLP-SRHQIVGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 2623
W K G LP SR++I L+I +VT D G Y C N G E S +T+Q
Sbjct: 255 RWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ----- 309
Query: 2624 HVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGS------LPSRHQTH 2677
P ++ V G+T+ C PQ I W + G P + +
Sbjct: 310 ----EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 365
Query: 2678 GS-----HLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIE 2732
S L + + +D G Y+C+ N ++ + V+ P IR
Sbjct: 366 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP----VIRQG 421
Query: 2733 SSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSH----HQTRGSRLRLHHVSPADS 2788
+ VA T L+CV G + W K G + + Q L++ + D+
Sbjct: 422 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 481
Query: 2789 GEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE 2840
G Y C SG S + ++ G V P P I PS V +
Sbjct: 482 GRYTCIASTPSGEATWSAYIEVQEFG-VPVQPPRPTDPNLIPSAPSKPEVTD 532
Score = 102 bits (253), Expect = 1e-20
Identities = 120/530 (22%), Positives = 202/530 (38%), Gaps = 61/530 (11%)
Query: 2158 PSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL------PARHQT---HGSLLRLHQV 2208
PS V++G+ LNC G+ + W+K G + P H+ GSL L V
Sbjct: 35 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 94
Query: 2209 ----TPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDL 2264
+ D G YVC G S ++E +++ R S VA G+ +
Sbjct: 95 HGRKSRPDEGVYVCVARNYLGEA-VSHNASLEVAILRDDF---RQNPSDVMVAVGEPAVM 150
Query: 2265 SCVVA-GQAHAQVTWYKRGGSLPARHQ---VRGSRLYIFQASPADAGQYVCRASNGMEAS 2320
C G ++W K G L + + +RG +L I +DAG+YVC +N
Sbjct: 151 ECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTN----- 205
Query: 2321 ITVTVTGTQGANLAYPAGSTQPIRIE-PSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGG 2379
+ G + + +A +P ++ PS+ V + + C G V W K G
Sbjct: 206 ----MVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 261
Query: 2380 SLP-VRHQTHGS-LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTP 2437
LP R++ L++ + + D G Y C EAS +T++ P
Sbjct: 262 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE---------PP 312
Query: 2438 TVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG-SLPARHQVHGSR--------- 2487
++ VA G+T+ C G + W + G +L +Q S
Sbjct: 313 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 372
Query: 2488 -LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLA 2546
L + V +D G Y+C+ + +G S++ ++ + +R + ++A
Sbjct: 373 DLTITNVQRSDVGYYICQTLNVAG----SIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 428
Query: 2547 NGHTLDLNCLVASQAPHTITWYKRGGSLPSR----HQIVGSRLRIPQVTPADSGEYVCHV 2602
T L+C+ TI W K G + ++ Q+ L+I D+G Y C
Sbjct: 429 VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 488
Query: 2603 SNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCV 2652
S +G S + +Q G P + S+P+ E + N V
Sbjct: 489 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTV 538
Score = 99.8 bits (247), Expect = 5e-20
Identities = 130/549 (23%), Positives = 200/549 (36%), Gaps = 95/549 (17%)
Query: 2620 SGSSHVPSVSPPIRIESSSPTVV-EGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHG 2678
SGS PP +E S +V +G+ LNC +P I WYK G + +
Sbjct: 18 SGSRLRQEDFPPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 77
Query: 2679 SHLRL-------------HQMSVADSGEYVCRANNNID---ALEASIVISVSPSAGSPSA 2722
SH L + S D G YVC A N + + AS+ +++
Sbjct: 78 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD------ 131
Query: 2723 PGSSMPIRIESSSSHVAEGETLDLNCVVP-GQAHAQVTWHKRGGSLPSHHQ---TRGSRL 2778
R S VA GE + C P G ++W K G L + RG +L
Sbjct: 132 -----DFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKL 186
Query: 2779 RLHHVSPADSGEYVCRVMGSSGPLEASV--LVTIEASGSSAVHVPAPGGAPPIRIEPSSS 2836
+ + +D+G+YVC G E+ V L +E P PS+
Sbjct: 187 MITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE--------------RPSFVKRPSNL 232
Query: 2837 RVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLP-ARHQVHGP-LLRLNQVSPADSGEYSCQ 2894
V + + KC G V W K G LP +R+++ L++ +V+ D G Y+C
Sbjct: 233 AVTVDDSAEFKCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCV 292
Query: 2895 VTGSSGTLEASVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHA 2954
G EAS +T++ P + +P V G+T+ C G
Sbjct: 293 AENMVGKAEASATLTVQE------PPHFVVKP-----RDQVVALGRTVTFQCEATGNPQP 341
Query: 2955 QVTWYKRGG-SLPARHQTHGSQLRLHL----------VSPADSGEYVCRAASGPGP-EQE 3002
+ W + G +L +Q S R + V +D G Y+C+ + G +
Sbjct: 342 AIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITK 401
Query: 3003 ASFTVTVPPSEGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQE 3062
A VT ++ PVI P + TV C+ P L W+
Sbjct: 402 AYLEVTDVIADRP-----PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTIL-WR----- 450
Query: 3063 LEDNVHISPNGS--------IITIVGTRPSNHGTYRCVASNAYGVA--QSVVNLSVHGPP 3112
+D V +S S ++ I + + G Y C+AS G A + + + G P
Sbjct: 451 -KDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVP 509
Query: 3113 TVSVLPEGP 3121
P P
Sbjct: 510 VQPPRPTDP 518
Score = 95.9 bits (237), Expect = 8e-19
Identities = 73/220 (33%), Positives = 101/220 (45%), Gaps = 14/220 (6%)
Query: 3461 QGTYICQAHGPWGKAQA-SAQLVIQALPSVLINIRTSVQTVVVGHAVEFECLA-LGDPKP 3518
+G Y+C A G+A + +A L + L + V V VG EC G P+P
Sbjct: 103 EGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVM-VAVGEPAVMECQPPRGHPEP 161
Query: 3519 QVTWSKVGGHLRPG---IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHV--LLLVQ 3573
++W K G L I GG + I + +DAG+Y C TN G +S V L +++
Sbjct: 162 TISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTVLE 221
Query: 3574 ALPQISMPQEVRVPAGSAAVFPCIASGYPTPDISWSKLDGSLPPDSRLE---NNMLMLPS 3630
+ P + V +A F C A G P P + W K DG L P SR E ++ L +
Sbjct: 222 RPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGEL-PKSRYEIRDDHTLKIRK 280
Query: 3631 VRPQDAGTYVCTATNRQGKVKAFAHLQVPERVVPYFTQTP 3670
V D G+Y C A N GK +A A L V E P+F P
Sbjct: 281 VTAGDMGSYTCVAENMVGKAEASATLTVQE--PPHFVVKP 318
Score = 52.8 bits (125), Expect = 8e-06
Identities = 35/92 (38%), Positives = 47/92 (51%), Gaps = 12/92 (13%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWR------LNWGHIP--SHPRVTVT 456
PP V PR+ + A G+TVTF C A G P P I WR L + + P S R +V+
Sbjct: 311 PPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 369
Query: 457 SEGGRGTLIIRDVKESDQGAYTCEAMNARGMV 488
G L I +V+ SD G Y C+ +N G +
Sbjct: 370 Q---TGDLTITNVQRSDVGYYICQTLNVAGSI 398
Score = 41.2 bits (95), Expect = 0.023
Identities = 27/81 (33%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P V P ++ + + F C A G P P + WR + G +P R + + TL
Sbjct: 223 PSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD---HTLK 277
Query: 466 IRDVKESDQGAYTCEAMNARG 486
IR V D G+YTC A N G
Sbjct: 278 IRKVTAGDMGSYTCVAENMVG 298
Score = 38.9 bits (89), Expect = 0.11
Identities = 30/97 (30%), Positives = 42/97 (43%), Gaps = 11/97 (11%)
Query: 397 RSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI------PSH 450
R ++F PP++V P + I S+G+ T C A G PTP I W + P
Sbjct: 23 RQEDF---PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 78
Query: 451 PRVTVTSEGGRGTLIIRDVK-ESDQGAYTCEAMNARG 486
R+ + S I+ K D+G Y C A N G
Sbjct: 79 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 115
Score = 37.7 bits (86), Expect = 0.25
Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 14/95 (14%)
Query: 398 SDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTS 457
+D PP V+ + + T +CVA G P P I WR + V V++
Sbjct: 407 TDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD--------GVLVST 458
Query: 458 EGGR------GTLIIRDVKESDQGAYTCEAMNARG 486
+ R G L IR K D G YTC A G
Sbjct: 459 QDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 493
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 170 bits (431), Expect = 3e-41
Identities = 149/500 (29%), Positives = 212/500 (42%), Gaps = 66/500 (13%)
Query: 3212 PQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSKLRSPL------PWQHR--LEGDTL 3263
P++ ++L V G ATL C A G P PTI W K + P HR L +L
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 3264 IIPRV-----AQQDSGQYICNATSPAGHA---EATIILHVESPPYATTVPEHASVQAGET 3315
R+ ++ D G Y+C A + G A A++ + + + P V GE
Sbjct: 128 FFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQN-PSDVMVAVGEP 186
Query: 3316 VQLQCLA-HGTPPLTFQWSRVGSSLPG---RATARNELLHFERAAPEDSGRYRCRVTNKV 3371
++C G P T W + GS L R T R L D+G+Y C TN V
Sbjct: 187 AVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTNMV 246
Query: 3372 GSAEA-FAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIGASVEFHCAVPSDRGTQ 3430
G E+ A+L V P + S + VT + S EF C D
Sbjct: 247 GERESEVAELTVLERPSFVKRPS-------NLAVT-------VDDSAEFKCEARGDPVPT 292
Query: 3431 LRWFKEGGQLPPGHSV--QDGVLRIQNLDQSCQGTYICQAHGPWGKAQASAQLVIQALPS 3488
+RW K+ G+LP D L+I+ + G+Y C A GKA+ASA L +Q P
Sbjct: 293 VRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH 352
Query: 3489 VLINIRTSVQTVVVGHAVEFECLALGDPKPQVTWSKVGGH------------LRPGIVQS 3536
++ R Q V +G V F+C A G+P+P + W + G R + Q+
Sbjct: 353 FVVKPRD--QVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
Query: 3537 GGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALPQISMPQEVR-------VPAG 3589
G + I +V+ +D G Y C N AG+ + L V + P +R V
Sbjct: 411 GDLT-ITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVNQTVAVD 469
Query: 3590 SAAVFPCIASGYPTPDISWSKLDGSL--PPDSR---LENNMLMLPSVRPQDAGTYVCTAT 3644
V C+A+G P P I W K DG L DSR LEN +L + + D G Y C A+
Sbjct: 470 GTFVLSCVATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAS 528
Query: 3645 NRQGKVKAFAHLQVPERVVP 3664
G+ A+++V E VP
Sbjct: 529 TPSGEATWSAYIEVQEFGVP 548
Score = 142 bits (358), Expect = 7e-33
Identities = 139/530 (26%), Positives = 198/530 (37%), Gaps = 46/530 (8%)
Query: 1666 GQCLPETNQAPLVVEVHPARSIVPQGGSHSLRCQVSGSPPHYFYWSR-----EDGRPVPS 1720
G L + + P +VE HP+ IV +G +L C+ G P W + E + P
Sbjct: 58 GSRLRQEDFPPRIVE-HPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPR 116
Query: 1721 GTQQRHQGSELHFPSV-----QPSDAGVYICTCRNLHQSNTSRAELLVTEAPSKPITVTV 1775
+ L F + D GVY+C RN V+ S + +
Sbjct: 117 SHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE-------AVSHNASLEVAILR 169
Query: 1776 EEQRSQS----VRPGADVTFICTAKSKSPAYTLVWTRLHN--GKLPTRAMDFNGILTIRN 1829
++ R V G C P T+ W + + R G L I
Sbjct: 170 DDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITY 229
Query: 1830 VQLSDAGTYVCTGSNMFAMDQGTATLHVQASGTLSAPVVSIHPPQLTVQPGQLAEFRCSA 1889
+ SDAG YVC G+NM G V L P P L V AEF+C A
Sbjct: 230 TRKSDAGKYVCVGTNMV----GERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEA 285
Query: 1890 TGSPTPTLEWTGGPGGQLPAKAQIHGG-ILRLPAVEPTDQAQYLCRAHSSAGQQVARAVL 1948
G P PT+ W G ++ +I L++ V D Y C A + G+ A A L
Sbjct: 286 RGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATL 345
Query: 1949 HVHGGGGPRVQVSPERTQVHAGRTVRLYCRAAGVPSATITWRKEGGS------LPPQARS 2002
V P V P V GRTV C A G P I WR+EG PPQ+ S
Sbjct: 346 TVQ--EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSS 403
Query: 2003 ERTDIAT--LLIPAITTADAGFYLCVATSPAGTAQARIQVVVLSA-SDASPPPVKIESSS 2059
+ T L I + +D G+Y+C + AG+ + + V +D PP ++ +
Sbjct: 404 RFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGPVN 463
Query: 2060 PSVTEGQTLDLNCVVAGSAHAQVTWYRRGGSLPPH----TQVHGSRLRLPQVSPADSGEY 2115
+V T L+CV GS + W + G + Q+ L++ D+G Y
Sbjct: 464 QTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRY 523
Query: 2116 VCRVENGSGPKEASITVSVLHGTHSGPSYTPVPGSTRPIRIEPSSSHVAE 2165
C SG EA+ + + P P P I PS V +
Sbjct: 524 TCIASTPSG--EATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTD 571
Score = 142 bits (358), Expect = 7e-33
Identities = 135/494 (27%), Positives = 199/494 (40%), Gaps = 49/494 (9%)
Query: 3022 PVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVH-------ISPNGS 3074
P I P V +G+ A+ C P ++EW + +E + + P+GS
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTP-TIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 3075 I--ITIVGTRPS--NHGTYRCVASNAYGVAQSVVNLSVHGPPTVSVLPEGP--VWVKVGK 3128
+ + IV R S + G Y CVA N G A S N S+ + P V V VG+
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSH-NASLEVAILRDDFRQNPSDVMVAVGE 185
Query: 3129 AVTLECVSA-GEPRSSARWTRISSTPAKLEQRTYGLMDSHAVLQISSAKPSDAGTYVCLA 3187
+EC G P + W + S L+ + + L I+ + SDAG YVC+
Sbjct: 186 PAVMECQPPRGHPEPTISWKKDGSP---LDDKDERITIRGGKLMITYTRKSDAGKYVCVG 242
Query: 3188 QNALGTAQKQVEVIVDTGAMAPGAPQVQAEEAELTVEAGHTATLRCSATGSPAPTIHWSK 3247
N +G + +V + P + L V +A +C A G P PT+ W K
Sbjct: 243 TNMVGERESEVAELT-----VLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRK 297
Query: 3248 LRSPLPW-QHRLEGD-TLIIPRVAQQDSGQYICNATSPAGHAEATIILHVESPPYATTVP 3305
LP ++ + D TL I +V D G Y C A + G AEA+ L V+ PP+ P
Sbjct: 298 DDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPHFVVKP 357
Query: 3306 EHASVQAGETVQLQCLAHGTPPLTFQWSRVGSS------LPGRATARNEL-----LHFER 3354
V G TV QC A G P W R GS P ++++R + L
Sbjct: 358 RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTGDLTITN 417
Query: 3355 AAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQVTPQLETKSIG 3414
D G Y C+ N GS A L V P P ++ P +T ++
Sbjct: 418 VQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRP--------PPVIRQGPVNQTVAVD 469
Query: 3415 ASVEFHCAVPSDRGTQLRWFKEGGQLPPGHS----VQDGVLRIQNLDQSCQGTYICQAHG 3470
+ C + W K+G + S +++GVL+I+ G Y C A
Sbjct: 470 GTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIAST 529
Query: 3471 PWGKAQASAQLVIQ 3484
P G+A SA + +Q
Sbjct: 530 PSGEATWSAYIEVQ 543
Score = 140 bits (353), Expect = 3e-32
Identities = 125/488 (25%), Positives = 187/488 (38%), Gaps = 66/488 (13%)
Query: 1866 PVVSIHPPQLTVQPGQLAEFRCSATGSPTPTLEWTGG------------------PGGQL 1907
P + HP L V G+ A C A G PTPT+EW G P G L
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 1908 PAKAQIHGGILRLPAVEPTDQAQYLCRAHSSAGQQVARAVLHVHGGGGPRVQVSPERTQV 1967
+HG R D+ Y+C A + G+ V+ + +P V
Sbjct: 128 FFLRIVHGRKSR------PDEGVYVCVARNYLGEAVSHNASLEVAILRDDFRQNPSDVMV 181
Query: 1968 HAGRTVRLYCRAA-GVPSATITWRKEGGSLPPQARSERTDI--ATLLIPAITTADAGFYL 2024
G + C+ G P TI+W+K+G P + ER I L+I +DAG Y+
Sbjct: 182 AVGEPAVMECQPPRGHPEPTISWKKDGS--PLDDKDERITIRGGKLMITYTRKSDAGKYV 239
Query: 2025 CVATSPAGTAQARI-QVVVLSASDASPPPVKIESSSPSVTEGQTLDLNCVVAGSAHAQVT 2083
CV T+ G ++ + ++ VL P S+ +VT + + C G V
Sbjct: 240 CVGTNMVGERESEVAELTVLERPSFVKRP-----SNLAVTVDDSAEFKCEARGDPVPTVR 294
Query: 2084 WYRRGGSLPPHTQV--HGSRLRLPQVSPADSGEYVCRVENGSGPKEASITVSVLHGTHSG 2141
W + G LP L++ +V+ D G Y C EN G EAS T++V H
Sbjct: 295 WRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPPH-- 352
Query: 2142 PSYTPVPGSTRPIRIEPSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGS------LPAR 2195
++P VA G+T+ C G + W + G P +
Sbjct: 353 ------------FVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQ 400
Query: 2196 HQTHGSL-----LRLHQVTPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIE 2250
+ S+ L + V +D G Y+C + +G + + + + P P +R
Sbjct: 401 SSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 460
Query: 2251 SSSSTVAEGQTLDLSCVVAGQAHAQVTWYKRGGSLPAR----HQVRGSRLYIFQASPADA 2306
+ TVA T LSCV G + W K G + + Q+ L I A D
Sbjct: 461 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 520
Query: 2307 GQYVCRAS 2314
G+Y C AS
Sbjct: 521 GRYTCIAS 528
Score = 120 bits (300), Expect = 4e-26
Identities = 132/562 (23%), Positives = 207/562 (36%), Gaps = 96/562 (17%)
Query: 2437 PTVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRG-------------------GSL 2477
P + S V++G+ LNC G+ + W+K G GSL
Sbjct: 68 PRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSL 127
Query: 2478 PARHQVHGSRLRLLQVTPADSGEYVC---RVVGSSGTQEASVLVTIQQRLSGSHSQGVAY 2534
VHG + R D G YVC +G + + AS+ V I +
Sbjct: 128 FFLRIVHGRKSR------PDEGVYVCVARNYLGEAVSHNASLEVAI-----------LRD 170
Query: 2535 PVRIESSSASLANGHTLDLNCLVASQAPH-TITWYKRGGSLPSRHQ---IVGSRLRIPQV 2590
R S +A G + C P TI+W K G L + + I G +L I
Sbjct: 171 DFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYT 230
Query: 2591 TPADSGEYVCHVSNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLN 2650
+D+G+YVC +N G RE+ + S V S+ V + +
Sbjct: 231 RKSDAGKYVCVGTNMVGERESEVAELTVLERPSFVK--------RPSNLAVTVDDSAEFK 282
Query: 2651 CVVARQPQAIITWYKRGGSLP-SRHQTHGSH-LRLHQMSVADSGEYVCRANNNIDALEAS 2708
C P + W K G LP SR++ H L++ +++ D G Y C A N + EAS
Sbjct: 283 CEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEAS 342
Query: 2709 IVISVSPSAGSPSAPGSSMPIRIESSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGS-- 2766
++V P + VA G T+ C G + W + G
Sbjct: 343 ATLTVQEPPHFVVKPRDQV----------VALGRTVTFQCEATGNPQPAIFWRREGSQNL 392
Query: 2767 ----LPSHHQTRGS-----RLRLHHVSPADSGEYVCRVMGSSGPLEASVLVTIEASGSSA 2817
P +R S L + +V +D G Y+C+ + +G + + +
Sbjct: 393 LFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEV------- 445
Query: 2818 VHVPAPGGAPPIRIEPSSSRVAEGQTLDLKCVVPGQAHAQVTWHKRGGNLPAR----HQV 2873
V A P IR P + VA T L CV G + W K G + + Q+
Sbjct: 446 TDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQL 505
Query: 2874 HGPLLRLNQVSPADSGEYSCQVTGSSGTLEASVLVTIE----------PSSPGPIPAPGL 2923
+L++ D+G Y+C + SG S + ++ P+ P IP+
Sbjct: 506 ENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPS-AP 564
Query: 2924 AQPIYIEASSSHVTEGQTLDLN 2945
++P + S + VT +LN
Sbjct: 565 SKPEVTDVSRNTVTLSWQPNLN 586
Score = 115 bits (288), Expect = 1e-24
Identities = 130/532 (24%), Positives = 200/532 (37%), Gaps = 72/532 (13%)
Query: 2347 PSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGGSL------PVRHQT---HGSLLRLY-- 2395
PS V++G+ LNC G+ + W+K G + P H+ GSL L
Sbjct: 74 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 133
Query: 2396 --QASPADSGEYVC---RVLGSSVPLEASVLVTIEPAGSVPALGVTPTVRIESSSSQVAE 2450
+ S D G YVC LG +V AS+ V I + R S VA
Sbjct: 134 HGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAI----------LRDDFRQNPSDVMVAV 183
Query: 2451 GQTLDLNCLVA-GQAHAQVTWHKRGGSLPARHQ---VHGSRLRLLQVTPADSGEYVCRVV 2506
G+ + C G ++W K G L + + + G +L + +D+G+YVC
Sbjct: 184 GEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGT 243
Query: 2507 GSSGTQEASVL-VTIQQRLSGSHSQGVAYPVRIESSSASLANGHTLDLNCLVASQAPHTI 2565
G +E+ V +T+ +R S V P S+ ++ + + C T+
Sbjct: 244 NMVGERESEVAELTVLERPSF-----VKRP-----SNLAVTVDDSAEFKCEARGDPVPTV 293
Query: 2566 TWYKRGGSLP-SRHQIVGSR-LRIPQVTPADSGEYVCHVSNGAGSRETSLIVTIQGSGSS 2623
W K G LP SR++I L+I +VT D G Y C N G E S +T+Q
Sbjct: 294 RWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQ----- 348
Query: 2624 HVPSVSPPIRIESSSPTVVEGQTLDLNCVVARQPQAIITWYKRGGS------LPSRHQTH 2677
P ++ V G+T+ C PQ I W + G P + +
Sbjct: 349 ----EPPHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSR 404
Query: 2678 GS-----HLRLHQMSVADSGEYVCRANNNIDALEASIVISVSPSAGSPSAPGSSMPIRIE 2732
S L + + +D G Y+C+ N ++ + V+ P IR
Sbjct: 405 FSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPP----VIRQG 460
Query: 2733 SSSSHVAEGETLDLNCVVPGQAHAQVTWHKRGGSLPSH----HQTRGSRLRLHHVSPADS 2788
+ VA T L+CV G + W K G + + Q L++ + D+
Sbjct: 461 PVNQTVAVDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDT 520
Query: 2789 GEYVCRVMGSSGPLEASVLVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAE 2840
G Y C SG S + ++ G V P P I PS V +
Sbjct: 521 GRYTCIASTPSGEATWSAYIEVQEFG-VPVQPPRPTDPNLIPSAPSKPEVTD 571
Score = 110 bits (276), Expect = 2e-23
Identities = 108/410 (26%), Positives = 155/410 (37%), Gaps = 52/410 (12%)
Query: 3298 PPYATTVPEHASVQAGETVQLQCLAHGTPPLTFQWSRVGSS--------------LPGRA 3343
PP P V GE L C A G P T +W + G LP +
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 3344 TARNELLHFERAAPEDSGRYRCRVTNKVGSAEAFAQLLVQGPPGSLPATSIPAGSTPTVQ 3403
++H ++ P D G Y C N +G A S A+ A +
Sbjct: 127 LFFLRIVHGRKSRP-DEGVYVCVARNYLGEAV------------SHNASLEVAILRDDFR 173
Query: 3404 VTPQLETKSIGASVEFHCAVPSDR-GTQLRWFKEGGQLPPGH---SVQDGVLRIQNLDQS 3459
P ++G C P + W K+G L +++ G L I +S
Sbjct: 174 QNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKS 233
Query: 3460 CQGTYICQAHGPWGKAQAS-AQLVIQALPSVLINIRTSVQTVVVGHAVEFECLALGDPKP 3518
G Y+C G+ ++ A+L + PS + R S V V + EF+C A GDP P
Sbjct: 234 DAGKYVCVGTNMVGERESEVAELTVLERPSFV--KRPSNLAVTVDDSAEFKCEARGDPVP 291
Query: 3519 QVTWSKVGGHLRPG--IVQSGGVVRIAHVELADAGQYRCTATNAAGTTQSHVLLLVQALP 3576
V W K G L ++ ++I V D G Y C A N G ++ L VQ P
Sbjct: 292 TVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQEPP 351
Query: 3577 Q-ISMPQEVRVPAGSAAVFPCIASGYPTPDISWSK------LDGSLPPDSR-----LENN 3624
+ P++ V G F C A+G P P I W + L PP S +
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 3625 MLMLPSVRPQDAGTYVCTATNRQGKVKAFAHLQV----PERVVPYFTQTP 3670
L + +V+ D G Y+C N G + A+L+V +R P Q P
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQGP 461
Score = 102 bits (253), Expect = 1e-20
Identities = 120/530 (22%), Positives = 202/530 (38%), Gaps = 61/530 (11%)
Query: 2158 PSSSHVAEGQTLDLNCVVPGQAHAQVTWHKRGGSL------PARHQT---HGSLLRLHQV 2208
PS V++G+ LNC G+ + W+K G + P H+ GSL L V
Sbjct: 74 PSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIV 133
Query: 2209 ----TPADSGEYVCHVVGTSGPLEASVLVTIEASVIPGPIPPVRIESSSSTVAEGQTLDL 2264
+ D G YVC G S ++E +++ R S VA G+ +
Sbjct: 134 HGRKSRPDEGVYVCVARNYLGEA-VSHNASLEVAILRDDF---RQNPSDVMVAVGEPAVM 189
Query: 2265 SCVVA-GQAHAQVTWYKRGGSLPARHQ---VRGSRLYIFQASPADAGQYVCRASNGMEAS 2320
C G ++W K G L + + +RG +L I +DAG+YVC +N
Sbjct: 190 ECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDAGKYVCVGTN----- 244
Query: 2321 ITVTVTGTQGANLAYPAGSTQPIRIE-PSSSQVAEGQTLDLNCVVPGQSHAQVTWHKRGG 2379
+ G + + +A +P ++ PS+ V + + C G V W K G
Sbjct: 245 ----MVGERESEVAELTVLERPSFVKRPSNLAVTVDDSAEFKCEARGDPVPTVRWRKDDG 300
Query: 2380 SLP-VRHQTHGS-LLRLYQASPADSGEYVCRVLGSSVPLEASVLVTIEPAGSVPALGVTP 2437
LP R++ L++ + + D G Y C EAS +T++ P
Sbjct: 301 ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQE---------PP 351
Query: 2438 TVRIESSSSQVAEGQTLDLNCLVAGQAHAQVTWHKRGG-SLPARHQVHGSR--------- 2487
++ VA G+T+ C G + W + G +L +Q S
Sbjct: 352 HFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQTG 411
Query: 2488 -LRLLQVTPADSGEYVCRVVGSSGTQEASVLVTIQQRLSGSHSQGVAYPVRIESSSASLA 2546
L + V +D G Y+C+ + +G S++ ++ + +R + ++A
Sbjct: 412 DLTITNVQRSDVGYYICQTLNVAG----SIITKAYLEVTDVIADRPPPVIRQGPVNQTVA 467
Query: 2547 NGHTLDLNCLVASQAPHTITWYKRGGSLPSR----HQIVGSRLRIPQVTPADSGEYVCHV 2602
T L+C+ TI W K G + ++ Q+ L+I D+G Y C
Sbjct: 468 VDGTFVLSCVATGSPVPTILWRKDGVLVSTQDSRIKQLENGVLQIRYAKLGDTGRYTCIA 527
Query: 2603 SNGAGSRETSLIVTIQGSGSSHVPSVSPPIRIESSSPTVVEGQTLDLNCV 2652
S +G S + +Q G P + S+P+ E + N V
Sbjct: 528 STPSGEATWSAYIEVQEFGVPVQPPRPTDPNLIPSAPSKPEVTDVSRNTV 577
Score = 99.4 bits (246), Expect = 7e-20
Identities = 127/539 (23%), Positives = 197/539 (36%), Gaps = 95/539 (17%)
Query: 2630 PPIRIESSSPTVV-EGQTLDLNCVVARQPQAIITWYKRGGSLPSRHQTHGSHLRL----- 2683
PP +E S +V +G+ LNC +P I WYK G + + SH L
Sbjct: 67 PPRIVEHPSDLIVSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRSHRMLLPSGS 126
Query: 2684 --------HQMSVADSGEYVCRANNNID---ALEASIVISVSPSAGSPSAPGSSMPIRIE 2732
+ S D G YVC A N + + AS+ +++ R
Sbjct: 127 LFFLRIVHGRKSRPDEGVYVCVARNYLGEAVSHNASLEVAILRD-----------DFRQN 175
Query: 2733 SSSSHVAEGETLDLNCVVP-GQAHAQVTWHKRGGSLPSHHQ---TRGSRLRLHHVSPADS 2788
S VA GE + C P G ++W K G L + RG +L + + +D+
Sbjct: 176 PSDVMVAVGEPAVMECQPPRGHPEPTISWKKDGSPLDDKDERITIRGGKLMITYTRKSDA 235
Query: 2789 GEYVCRVMGSSGPLEASV--LVTIEASGSSAVHVPAPGGAPPIRIEPSSSRVAEGQTLDL 2846
G+YVC G E+ V L +E P PS+ V + +
Sbjct: 236 GKYVCVGTNMVGERESEVAELTVLE--------------RPSFVKRPSNLAVTVDDSAEF 281
Query: 2847 KCVVPGQAHAQVTWHKRGGNLP-ARHQVHGP-LLRLNQVSPADSGEYSCQVTGSSGTLEA 2904
KC G V W K G LP +R+++ L++ +V+ D G Y+C G EA
Sbjct: 282 KCEARGDPVPTVRWRKDDGELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEA 341
Query: 2905 SVLVTIEPSSPGPIPAPGLAQPIYIEASSSHVTEGQTLDLNCVVPGQAHAQVTWYKRGG- 2963
S +T++ P + +P V G+T+ C G + W + G
Sbjct: 342 SATLTVQE------PPHFVVKP-----RDQVVALGRTVTFQCEATGNPQPAIFWRREGSQ 390
Query: 2964 SLPARHQTHGSQLRLHL----------VSPADSGEYVCRAASGPGP-EQEASFTVTVPPS 3012
+L +Q S R + V +D G Y+C+ + G +A VT +
Sbjct: 391 NLLFSYQPPQSSSRFSVSQTGDLTITNVQRSDVGYYICQTLNVAGSIITKAYLEVTDVIA 450
Query: 3013 EGSSYRLRSPVISIDPPSSTVQQGQDASFKCLIHDGAAPISLEWKTRNQELEDNVHISPN 3072
+ PVI P + TV C+ P L W+ +D V +S
Sbjct: 451 DRP-----PPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTIL-WR------KDGVLVSTQ 498
Query: 3073 GS--------IITIVGTRPSNHGTYRCVASNAYGVA--QSVVNLSVHGPPTVSVLPEGP 3121
S ++ I + + G Y C+AS G A + + + G P P P
Sbjct: 499 DSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSGEATWSAYIEVQEFGVPVQPPRPTDP 557
Score = 52.8 bits (125), Expect = 8e-06
Identities = 35/92 (38%), Positives = 47/92 (51%), Gaps = 12/92 (13%)
Query: 405 PPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWR------LNWGHIP--SHPRVTVT 456
PP V PR+ + A G+TVTF C A G P P I WR L + + P S R +V+
Sbjct: 350 PPHFVVKPRDQVVAL-GRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVS 408
Query: 457 SEGGRGTLIIRDVKESDQGAYTCEAMNARGMV 488
G L I +V+ SD G Y C+ +N G +
Sbjct: 409 Q---TGDLTITNVQRSDVGYYICQTLNVAGSI 437
Score = 41.2 bits (95), Expect = 0.023
Identities = 27/81 (33%), Positives = 37/81 (45%), Gaps = 5/81 (6%)
Query: 406 PQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTSEGGRGTLI 465
P V P ++ + + F C A G P P + WR + G +P R + + TL
Sbjct: 262 PSFVKRP-SNLAVTVDDSAEFKCEARGDPVPTVRWRKDDGELPK-SRYEIRDD---HTLK 316
Query: 466 IRDVKESDQGAYTCEAMNARG 486
IR V D G+YTC A N G
Sbjct: 317 IRKVTAGDMGSYTCVAENMVG 337
Score = 38.9 bits (89), Expect = 0.11
Identities = 30/97 (30%), Positives = 42/97 (43%), Gaps = 11/97 (11%)
Query: 397 RSDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHI------PSH 450
R ++F PP++V P + I S+G+ T C A G PTP I W + P
Sbjct: 62 RQEDF---PPRIVEHPSDLI-VSKGEPATLNCKAEGRPTPTIEWYKGGERVETDKDDPRS 117
Query: 451 PRVTVTSEGGRGTLIIRDVK-ESDQGAYTCEAMNARG 486
R+ + S I+ K D+G Y C A N G
Sbjct: 118 HRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLG 154
Score = 37.7 bits (86), Expect = 0.25
Identities = 29/95 (30%), Positives = 38/95 (40%), Gaps = 14/95 (14%)
Query: 398 SDEFGCMPPQVVTPPRESIQASRGQTVTFTCVAIGVPTPIINWRLNWGHIPSHPRVTVTS 457
+D PP V+ + + T +CVA G P P I WR + V V++
Sbjct: 446 TDVIADRPPPVIRQGPVNQTVAVDGTFVLSCVATGSPVPTILWRKD--------GVLVST 497
Query: 458 EGGR------GTLIIRDVKESDQGAYTCEAMNARG 486
+ R G L IR K D G YTC A G
Sbjct: 498 QDSRIKQLENGVLQIRYAKLGDTGRYTCIASTPSG 532
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 207,209,965
Number of Sequences: 37866
Number of extensions: 11677210
Number of successful extensions: 85558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 464
Number of HSP's successfully gapped in prelim test: 529
Number of HSP's that attempted gapping in prelim test: 33417
Number of HSP's gapped (non-prelim): 22856
length of query: 4391
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4268
effective length of database: 13,590,000
effective search space: 58002120000
effective search space used: 58002120000
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.