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Search of human proteins with 42476123
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42476123 RUN and SH3 domain containing 1 isoform d [Homo
sapiens]
(433 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|157412249 RUN and SH3 domain containing 1 isoform c [Homo sap... 871 0.0
gi|157412245 RUN and SH3 domain containing 1 isoform a [Homo sap... 871 0.0
gi|42476123 RUN and SH3 domain containing 1 isoform d [Homo sapi... 871 0.0
gi|157412247 RUN and SH3 domain containing 1 isoform b [Homo sap... 367 e-101
gi|209862765 RUN and SH3 domain containing 2 [Homo sapiens] 256 3e-68
gi|55741719 RUN and SH3 domain containing 2 [Homo sapiens] 256 3e-68
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 50 5e-06
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 50 5e-06
gi|5031681 embryonal Fyn-associated substrate isoform 1 [Homo sa... 47 3e-05
gi|156071465 Rho GTPase activating protein 4 [Homo sapiens] 47 4e-05
gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens] 46 6e-05
gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Ho... 46 8e-05
gi|110611233 alpha 1 type XVIII collagen isoform 2 precursor [Ho... 46 8e-05
gi|110611235 alpha 1 type XVIII collagen isoform 1 precursor [Ho... 46 8e-05
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 45 1e-04
gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [H... 45 1e-04
gi|61743946 abl-interactor 1 isoform c [Homo sapiens] 45 1e-04
gi|20149528 proline-serine-threonine phosphatase interacting pro... 45 1e-04
gi|239756943 PREDICTED: hypothetical protein [Homo sapiens] 45 2e-04
gi|239751443 PREDICTED: hypothetical protein [Homo sapiens] 45 2e-04
gi|239745948 PREDICTED: hypothetical protein XP_002343622 [Homo ... 45 2e-04
gi|61743942 abl-interactor 1 isoform a [Homo sapiens] 44 2e-04
gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-lik... 43 6e-04
gi|109689723 abl interactor 2 [Homo sapiens] 43 6e-04
gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens] 42 8e-04
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 42 8e-04
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 42 8e-04
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 42 8e-04
gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens] 42 0.001
gi|44662836 breast cancer anti-estrogen resistance 1 [Homo sapiens] 41 0.002
>gi|157412249 RUN and SH3 domain containing 1 isoform c [Homo
sapiens]
Length = 492
Score = 871 bits (2250), Expect = 0.0
Identities = 433/433 (100%), Positives = 433/433 (100%)
Query: 1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT 60
MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT
Sbjct: 60 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT 119
Query: 61 TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL 120
TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL
Sbjct: 120 TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL 179
Query: 121 SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL 180
SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL
Sbjct: 180 SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL 239
Query: 181 LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT 240
LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT
Sbjct: 240 LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT 299
Query: 241 SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER 300
SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER
Sbjct: 300 SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER 359
Query: 301 PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM 360
PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM
Sbjct: 360 PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM 419
Query: 361 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 420
PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM
Sbjct: 420 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 479
Query: 421 EGLVPVGYTSLVL 433
EGLVPVGYTSLVL
Sbjct: 480 EGLVPVGYTSLVL 492
>gi|157412245 RUN and SH3 domain containing 1 isoform a [Homo
sapiens]
Length = 902
Score = 871 bits (2250), Expect = 0.0
Identities = 433/433 (100%), Positives = 433/433 (100%)
Query: 1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT 60
MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT
Sbjct: 470 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT 529
Query: 61 TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL 120
TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL
Sbjct: 530 TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL 589
Query: 121 SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL 180
SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL
Sbjct: 590 SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL 649
Query: 181 LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT 240
LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT
Sbjct: 650 LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT 709
Query: 241 SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER 300
SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER
Sbjct: 710 SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER 769
Query: 301 PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM 360
PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM
Sbjct: 770 PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM 829
Query: 361 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 420
PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM
Sbjct: 830 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 889
Query: 421 EGLVPVGYTSLVL 433
EGLVPVGYTSLVL
Sbjct: 890 EGLVPVGYTSLVL 902
Score = 30.8 bits (68), Expect = 2.5
Identities = 20/63 (31%), Positives = 23/63 (36%), Gaps = 7/63 (11%)
Query: 204 LGPPQAPAPPGPP------PALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTP 257
L PP+ P PP PP P LQ + GR G AA +P L
Sbjct: 396 LVPPRPPPPPVPPRRKKNRPGLQPIAEGQSE-EGRAVSPAAGEEAPAAKEPGAQAGLEVR 454
Query: 258 GSW 260
SW
Sbjct: 455 SSW 457
>gi|42476123 RUN and SH3 domain containing 1 isoform d [Homo
sapiens]
Length = 433
Score = 871 bits (2250), Expect = 0.0
Identities = 433/433 (100%), Positives = 433/433 (100%)
Query: 1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT 60
MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT
Sbjct: 1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT 60
Query: 61 TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL 120
TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL
Sbjct: 61 TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL 120
Query: 121 SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL 180
SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL
Sbjct: 121 SSSRSRFHAFILGLLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLL 180
Query: 181 LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT 240
LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT
Sbjct: 181 LLQPLSVLTFHLDLLFEHHHHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGT 240
Query: 241 SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER 300
SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER
Sbjct: 241 SKEAASDPSDSPNLPTPGSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQER 300
Query: 301 PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM 360
PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM
Sbjct: 301 PLPTDEMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEM 360
Query: 361 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 420
PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM
Sbjct: 361 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 420
Query: 421 EGLVPVGYTSLVL 433
EGLVPVGYTSLVL
Sbjct: 421 EGLVPVGYTSLVL 433
>gi|157412247 RUN and SH3 domain containing 1 isoform b [Homo
sapiens]
Length = 796
Score = 367 bits (941), Expect = e-101
Identities = 176/176 (100%), Positives = 176/176 (100%)
Query: 258 GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGR 317
GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGR
Sbjct: 621 GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGR 680
Query: 318 LFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTH 377
LFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTH
Sbjct: 681 LFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTH 740
Query: 378 RAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL 433
RAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL
Sbjct: 741 RAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL 796
Score = 295 bits (754), Expect = 7e-80
Identities = 152/152 (100%), Positives = 152/152 (100%)
Query: 1 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT 60
MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT
Sbjct: 470 MAEAQSGTGQLQEQKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLT 529
Query: 61 TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL 120
TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL
Sbjct: 530 TLCPALHALVADGLKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPL 589
Query: 121 SSSRSRFHAFILGLLNTKQLELWFSSLQEDAG 152
SSSRSRFHAFILGLLNTKQLELWFSSLQEDAG
Sbjct: 590 SSSRSRFHAFILGLLNTKQLELWFSSLQEDAG 621
Score = 30.8 bits (68), Expect = 2.5
Identities = 20/63 (31%), Positives = 23/63 (36%), Gaps = 7/63 (11%)
Query: 204 LGPPQAPAPPGPP------PALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTP 257
L PP+ P PP PP P LQ + GR G AA +P L
Sbjct: 396 LVPPRPPPPPVPPRRKKNRPGLQPIAEGQSE-EGRAVSPAAGEEAPAAKEPGAQAGLEVR 454
Query: 258 GSW 260
SW
Sbjct: 455 SSW 457
>gi|209862765 RUN and SH3 domain containing 2 [Homo sapiens]
Length = 1516
Score = 256 bits (654), Expect = 3e-68
Identities = 187/516 (36%), Positives = 250/516 (48%), Gaps = 102/516 (19%)
Query: 14 QKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADG 73
QKKGL+ AV+++VD I++HFG +R+ KA+LG+S +SP+VGHLVL LCPA+ A++ DG
Sbjct: 992 QKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSPNVGHLVLKYLCPAVRAVLEDG 1051
Query: 74 LKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPLSSSRSRFHAFILG 133
LK F D+I GQR++ PWSVVEAS + G ST+ L LY++VS+ L+S RF+AFILG
Sbjct: 1052 LKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGLYNKVSQFPELTSHTMRFNAFILG 1111
Query: 134 LLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLLLLQPLSVLTFHLD 193
LLN + LE WF+ L ++ Y P GF S A CP L ELLLLLQPL++L F LD
Sbjct: 1112 LLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAHTVCPGLFEELLLLLQPLALLPFSLD 1171
Query: 194 LLFEH--------------------------HHHLPLGPPQAPAPPGPPPALQQTMQAM- 226
LLF+H H L L + PG Q +
Sbjct: 1172 LLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHSTLQLARARGQEGPGDVDRAAQGERVKG 1231
Query: 227 --LHFGGRLAQSLRGTSKEA-ASDPSDSPNLPTPGS--WWEQLTQASRVYASGGTEGFPL 281
GG + T + A A+ S G WW QL Q+S+VY G EG
Sbjct: 1232 VGASEGGEEEEEEEETEEVAEAAGGSGRARWARGGQAGWWYQLMQSSQVYIDGSIEG--- 1288
Query: 282 SRWAPGRHGTAAE---------------------EGAQERPLPTDEMAPGRG--LWLG-- 316
SR+ G +++E EGA+ P + + RG W+G
Sbjct: 1289 SRFPRGSSNSSSEKKKGAGGGGPPQAPPPREGVVEGAEACPASEEALGRERGWPFWMGSP 1348
Query: 317 ------------RLFGVPGGPAENENGALK------------------------SRRPSS 340
G PAENE GA + +R PS
Sbjct: 1349 PDSVLAELRRSREREGPAASPAENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSD 1408
Query: 341 WLPPTVSVLALVKR--GAPPEMPSPQEL--EASAPRMVQTHRA-VRALCDHTAARPDQLS 395
WL S+ LV + G+ E P P+E E +P + + V+ALC H A P QLS
Sbjct: 1409 WLSLDKSMFQLVAQTVGSRRE-PEPKESLQEPHSPALPSSPPCEVQALCHHLATGPGQLS 1467
Query: 396 FRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSL 431
F +G++LRV+ DWLRC R GLVP+ Y +L
Sbjct: 1468 FHKGDILRVLGRAGGDWLRCSRGPDSGLVPLAYVTL 1503
>gi|55741719 RUN and SH3 domain containing 2 [Homo sapiens]
Length = 1516
Score = 256 bits (654), Expect = 3e-68
Identities = 187/516 (36%), Positives = 250/516 (48%), Gaps = 102/516 (19%)
Query: 14 QKKGLLIAVSVSVDKIISHFGAARNLVQKAQLGDSRLSPDVGHLVLTTLCPALHALVADG 73
QKKGL+ AV+++VD I++HFG +R+ KA+LG+S +SP+VGHLVL LCPA+ A++ DG
Sbjct: 992 QKKGLVKAVNIAVDLIVAHFGTSRDPGVKAKLGNSSVSPNVGHLVLKYLCPAVRAVLEDG 1051
Query: 74 LKPFRKDLITGQRRSSPWSVVEASVKPGSSTRSLGTLYSQVSRLAPLSSSRSRFHAFILG 133
LK F D+I GQR++ PWSVVEAS + G ST+ L LY++VS+ L+S RF+AFILG
Sbjct: 1052 LKAFVLDVIIGQRKNMPWSVVEASTQLGPSTKVLHGLYNKVSQFPELTSHTMRFNAFILG 1111
Query: 134 LLNTKQLELWFSSLQEDAGLLSLLYLPTGFFSLARGGCPSLSTELLLLLQPLSVLTFHLD 193
LLN + LE WF+ L ++ Y P GF S A CP L ELLLLLQPL++L F LD
Sbjct: 1112 LLNIRSLEFWFNHLYNHEDIIQTHYQPWGFLSAAHTVCPGLFEELLLLLQPLALLPFSLD 1171
Query: 194 LLFEH--------------------------HHHLPLGPPQAPAPPGPPPALQQTMQAM- 226
LLF+H H L L + PG Q +
Sbjct: 1172 LLFQHRLLQSGQQQRQHKELLRVSQDLLLSAHSTLQLARARGQEGPGDVDRAAQGERVKG 1231
Query: 227 --LHFGGRLAQSLRGTSKEA-ASDPSDSPNLPTPGS--WWEQLTQASRVYASGGTEGFPL 281
GG + T + A A+ S G WW QL Q+S+VY G EG
Sbjct: 1232 VGASEGGEEEEEEEETEEVAEAAGGSGRARWARGGQAGWWYQLMQSSQVYIDGSIEG--- 1288
Query: 282 SRWAPGRHGTAAE---------------------EGAQERPLPTDEMAPGRG--LWLG-- 316
SR+ G +++E EGA+ P + + RG W+G
Sbjct: 1289 SRFPRGSSNSSSEKKKGAGGGGPPQAPPPREGVVEGAEACPASEEALGRERGWPFWMGSP 1348
Query: 317 ------------RLFGVPGGPAENENGALK------------------------SRRPSS 340
G PAENE GA + +R PS
Sbjct: 1349 PDSVLAELRRSREREGPAASPAENEEGASEPSPGGIKWGHLFGSRKAQREARPTNRLPSD 1408
Query: 341 WLPPTVSVLALVKR--GAPPEMPSPQEL--EASAPRMVQTHRA-VRALCDHTAARPDQLS 395
WL S+ LV + G+ E P P+E E +P + + V+ALC H A P QLS
Sbjct: 1409 WLSLDKSMFQLVAQTVGSRRE-PEPKESLQEPHSPALPSSPPCEVQALCHHLATGPGQLS 1467
Query: 396 FRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSL 431
F +G++LRV+ DWLRC R GLVP+ Y +L
Sbjct: 1468 FHKGDILRVLGRAGGDWLRCSRGPDSGLVPLAYVTL 1503
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 49.7 bits (117), Expect = 5e-06
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 322 PGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVR 381
PGG E E A +R W P + + L+ G P+ + + Q V
Sbjct: 1108 PGGWWEGELQARGKKRQIGWFP--ANYVKLLSPGTSKITPTEPPKSTALAAVCQ----VI 1161
Query: 382 ALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSL 431
+ D+TA D+L+F +G+++ V+ D DW + +G GL P Y L
Sbjct: 1162 GMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 49.7 bits (117), Expect = 5e-06
Identities = 31/110 (28%), Positives = 49/110 (44%), Gaps = 6/110 (5%)
Query: 322 PGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVR 381
PGG E E A +R W P + + L+ G P+ + + Q V
Sbjct: 1108 PGGWWEGELQARGKKRQIGWFP--ANYVKLLSPGTSKITPTEPPKSTALAAVCQ----VI 1161
Query: 382 ALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSL 431
+ D+TA D+L+F +G+++ V+ D DW + +G GL P Y L
Sbjct: 1162 GMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211
>gi|5031681 embryonal Fyn-associated substrate isoform 1 [Homo
sapiens]
Length = 561
Score = 47.0 bits (110), Expect = 3e-05
Identities = 24/56 (42%), Positives = 32/56 (57%), Gaps = 4/56 (7%)
Query: 381 RALCDHTAARPDQLSFRRGEVLRVITTVD----EDWLRCGRDGMEGLVPVGYTSLV 432
RAL D+TA P +LSFRRG+VLRV+ + W C G +G+VP L+
Sbjct: 11 RALYDNTAESPQELSFRRGDVLRVLQREGAGGLDGWCLCSLHGQQGIVPANRVKLL 66
Score = 32.3 bits (72), Expect = 0.86
Identities = 33/104 (31%), Positives = 43/104 (41%), Gaps = 18/104 (17%)
Query: 200 HHLPLGPPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGS 259
+ +PL P+AP P PP AL H LAQ L + P P LP+ S
Sbjct: 253 YDVPLLGPEAPPSPEPPGALAS------HDQDTLAQLL-----ARSPPPPHRPRLPSAES 301
Query: 260 WWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLP 303
+ A V + P+ APGR G+ Q+RPLP
Sbjct: 302 LSRRPLPALPVPEAPSPS--PVPSPAPGRKGS-----IQDRPLP 338
>gi|156071465 Rho GTPase activating protein 4 [Homo sapiens]
Length = 946
Score = 46.6 bits (109), Expect = 4e-05
Identities = 32/92 (34%), Positives = 42/92 (45%), Gaps = 4/92 (4%)
Query: 343 PPTVSVLA---LVKRGAPPEMPSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRG 399
PP+ S L L GA E E+ A + AV +T +LSFRRG
Sbjct: 712 PPSASCLGDAQLESLGADNEPELEAEMPAQEDDLEGVVEAVACFA-YTGRTAQELSFRRG 770
Query: 400 EVLRVITTVDEDWLRCGRDGMEGLVPVGYTSL 431
+VLR+ DW R +GM GL+P Y +L
Sbjct: 771 DVLRLHERASSDWWRGEHNGMRGLIPHKYITL 802
>gi|4557377 Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]
Length = 659
Score = 46.2 bits (108), Expect = 6e-05
Identities = 32/109 (29%), Positives = 50/109 (45%), Gaps = 12/109 (11%)
Query: 327 ENENGALKS----RRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTHRAVRA 382
EN NG+LK R+ LPPT ++K+ PPE A+AP + V A
Sbjct: 169 ENRNGSLKPGSSHRKTKKPLPPTPEEDQILKKPLPPE-------PAAAPVSTSELKKVVA 221
Query: 383 LCDHTAARPDQLSFRRGEVLRVITTVDEDWLRC-GRDGMEGLVPVGYTS 430
L D+ + L R+G+ ++ + W R ++G EG +P Y +
Sbjct: 222 LYDYMPMNANDLQLRKGDEYFILEESNLPWWRARDKNGQEGYIPSNYVT 270
>gi|206597445 alpha 1 type XVIII collagen isoform 3 precursor [Homo
sapiens]
Length = 1751
Score = 45.8 bits (107), Expect = 8e-05
Identities = 44/130 (33%), Positives = 54/130 (41%), Gaps = 17/130 (13%)
Query: 203 PLGPPQAPAPPGPP-PALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLP----TP 257
P GPP P PPGPP P L M GG + R +A P P LP P
Sbjct: 1005 PAGPPGPPGPPGPPGPGLPAGFDDMEGSGGPFWSTAR-----SADGPQGPPGLPGLKGDP 1059
Query: 258 GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQ-ERPLPTDEMAPGR-GLWL 315
G L A + G GFP PGR G A +G + +R ++ PG+ G+
Sbjct: 1060 GV--PGLPGAKGEVGADGVPGFP---GLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQ 1114
Query: 316 GRLFGVPGGP 325
L G PG P
Sbjct: 1115 PGLPGPPGPP 1124
Score = 34.7 bits (78), Expect = 0.17
Identities = 52/178 (29%), Positives = 62/178 (34%), Gaps = 40/178 (22%)
Query: 205 GPPQAPAPPGPP-PALQQTMQAMLH-----FGGRLAQSLRGTSKEAASDPSDSPNLP-TP 257
GPP PPGPP P+ + + FGG L ++LRG P P +P P
Sbjct: 861 GPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDL-EALRG--PRGFPGPPGPPGVPGLP 917
Query: 258 GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGR 317
G +S V G G P PG G G P E PGR G
Sbjct: 918 GEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGPPGP-----PGREGPPGRTGQKGS 972
Query: 318 L--FGVPG--------GP--AENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSP 363
L G PG GP A E+G + P+ PP PP P P
Sbjct: 973 LGEAGAPGHKGSKGAPGPAGARGESGLAGAPGPAG--PP-----------GPPGPPGP 1017
>gi|110611233 alpha 1 type XVIII collagen isoform 2 precursor [Homo
sapiens]
Length = 1336
Score = 45.8 bits (107), Expect = 8e-05
Identities = 44/130 (33%), Positives = 54/130 (41%), Gaps = 17/130 (13%)
Query: 203 PLGPPQAPAPPGPP-PALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLP----TP 257
P GPP P PPGPP P L M GG + R +A P P LP P
Sbjct: 590 PAGPPGPPGPPGPPGPGLPAGFDDMEGSGGPFWSTAR-----SADGPQGPPGLPGLKGDP 644
Query: 258 GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQ-ERPLPTDEMAPGR-GLWL 315
G L A + G GFP PGR G A +G + +R ++ PG+ G+
Sbjct: 645 GV--PGLPGAKGEVGADGVPGFP---GLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQ 699
Query: 316 GRLFGVPGGP 325
L G PG P
Sbjct: 700 PGLPGPPGPP 709
Score = 34.7 bits (78), Expect = 0.17
Identities = 52/178 (29%), Positives = 62/178 (34%), Gaps = 40/178 (22%)
Query: 205 GPPQAPAPPGPP-PALQQTMQAMLH-----FGGRLAQSLRGTSKEAASDPSDSPNLP-TP 257
GPP PPGPP P+ + + FGG L ++LRG P P +P P
Sbjct: 446 GPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDL-EALRG--PRGFPGPPGPPGVPGLP 502
Query: 258 GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGR 317
G +S V G G P PG G G P E PGR G
Sbjct: 503 GEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGPPGP-----PGREGPPGRTGQKGS 557
Query: 318 L--FGVPG--------GP--AENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSP 363
L G PG GP A E+G + P+ PP PP P P
Sbjct: 558 LGEAGAPGHKGSKGAPGPAGARGESGLAGAPGPAG--PP-----------GPPGPPGP 602
>gi|110611235 alpha 1 type XVIII collagen isoform 1 precursor [Homo
sapiens]
Length = 1516
Score = 45.8 bits (107), Expect = 8e-05
Identities = 44/130 (33%), Positives = 54/130 (41%), Gaps = 17/130 (13%)
Query: 203 PLGPPQAPAPPGPP-PALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLP----TP 257
P GPP P PPGPP P L M GG + R +A P P LP P
Sbjct: 770 PAGPPGPPGPPGPPGPGLPAGFDDMEGSGGPFWSTAR-----SADGPQGPPGLPGLKGDP 824
Query: 258 GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQ-ERPLPTDEMAPGR-GLWL 315
G L A + G GFP PGR G A +G + +R ++ PG+ G+
Sbjct: 825 GV--PGLPGAKGEVGADGVPGFP---GLPGREGIAGPQGPKGDRGSRGEKGDPGKDGVGQ 879
Query: 316 GRLFGVPGGP 325
L G PG P
Sbjct: 880 PGLPGPPGPP 889
Score = 34.7 bits (78), Expect = 0.17
Identities = 52/178 (29%), Positives = 62/178 (34%), Gaps = 40/178 (22%)
Query: 205 GPPQAPAPPGPP-PALQQTMQAMLH-----FGGRLAQSLRGTSKEAASDPSDSPNLP-TP 257
GPP PPGPP P+ + + FGG L ++LRG P P +P P
Sbjct: 626 GPPGPQGPPGPPGPSFRHDKLTFIDMEGSGFGGDL-EALRG--PRGFPGPPGPPGVPGLP 682
Query: 258 GSWWEQLTQASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGR 317
G +S V G G P PG G G P E PGR G
Sbjct: 683 GEPGRFGVNSSDVPGPAGLPGVPGREGPPGFPGLPGPPGP-----PGREGPPGRTGQKGS 737
Query: 318 L--FGVPG--------GP--AENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSP 363
L G PG GP A E+G + P+ PP PP P P
Sbjct: 738 LGEAGAPGHKGSKGAPGPAGARGESGLAGAPGPAG--PP-----------GPPGPPGP 782
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/119 (35%), Positives = 56/119 (47%), Gaps = 9/119 (7%)
Query: 312 GLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAP 371
G WLG+ G G N L S PS P SV +R PP++ S S P
Sbjct: 119 GWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQR--PPKLSSLAY--DSPP 174
Query: 372 RMVQT--HRAV-RALCDHTAARPDQLSFRRGEVLRVI--TTVDEDWLRCGRDGMEGLVP 425
+QT H V R L D+ PD+L+ RRG+V++V+ TT D+ W G G+ P
Sbjct: 175 DYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFP 233
Score = 31.6 bits (70), Expect = 1.5
Identities = 17/80 (21%), Positives = 35/80 (43%), Gaps = 13/80 (16%)
Query: 353 KRGAPPEMPSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDW 412
+RG P + P PQ R + ++ + D+L + GE++ +I +++ W
Sbjct: 74 RRGHPAKHPRPQ-------------RWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGW 120
Query: 413 LRCGRDGMEGLVPVGYTSLV 432
++G G P + L+
Sbjct: 121 WLGKKNGQLGAFPSNFVELL 140
>gi|242117948 SH3 domain-containing protein C1orf113 isoform 2 [Homo
sapiens]
Length = 645
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/119 (35%), Positives = 56/119 (47%), Gaps = 9/119 (7%)
Query: 312 GLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAP 371
G WLG+ G G N L S PS P SV +R PP++ S S P
Sbjct: 8 GWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPDMPSVSPGPQR--PPKLSSLAY--DSPP 63
Query: 372 RMVQT--HRAV-RALCDHTAARPDQLSFRRGEVLRVI--TTVDEDWLRCGRDGMEGLVP 425
+QT H V R L D+ PD+L+ RRG+V++V+ TT D+ W G G+ P
Sbjct: 64 DYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFP 122
>gi|61743946 abl-interactor 1 isoform c [Homo sapiens]
Length = 452
Score = 45.1 bits (105), Expect = 1e-04
Identities = 33/129 (25%), Positives = 51/129 (39%), Gaps = 18/129 (13%)
Query: 321 VPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTH--- 377
V GGP ++N S P PP + + PP P P + E +VQ +
Sbjct: 322 VNGGPLYSQNSIADSPTPPP--PPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPY 379
Query: 378 -------------RAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLV 424
V A+ D+T + D+LSF G ++ VI D+ W + + GL
Sbjct: 380 ADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLF 439
Query: 425 PVGYTSLVL 433
P Y ++
Sbjct: 440 PGNYVESIM 448
>gi|20149528 proline-serine-threonine phosphatase interacting
protein 1 [Homo sapiens]
Length = 416
Score = 45.1 bits (105), Expect = 1e-04
Identities = 23/65 (35%), Positives = 34/65 (52%), Gaps = 3/65 (4%)
Query: 364 QELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGL 423
QE++ + Q +RA L D+TA PD+L G++L VI ++ W R+G G
Sbjct: 351 QEIQGNPASPAQEYRA---LYDYTAQNPDELDLSAGDILEVILEGEDGWWTVERNGQRGF 407
Query: 424 VPVGY 428
VP Y
Sbjct: 408 VPGSY 412
>gi|239756943 PREDICTED: hypothetical protein [Homo sapiens]
Length = 783
Score = 44.7 bits (104), Expect = 2e-04
Identities = 55/189 (29%), Positives = 73/189 (38%), Gaps = 31/189 (16%)
Query: 214 GPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYAS 273
GP P Q+ Q+ H G + ++ + DSP P S W QL +
Sbjct: 459 GPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAG--GG 516
Query: 274 GGTEGFPLSRWA---PGRHGTAAEEGAQERPLPTDEMAPGR-GLWLGRLFGVPGGPAENE 329
G EG RWA PG G A G Q PLP E PG G L R GP +
Sbjct: 517 RGWEGRGAGRWARPGPGWDG-GARAGTQGLPLPGTEAEPGALGCSLSR------GPVPRQ 569
Query: 330 NGALKSR-------------RPSSWLPPTVSV--LALVKRGAPPEMPSPQELEASAPRMV 374
L +R + ++ P + V L L + A P +P+P L+A R
Sbjct: 570 GSLLSARVGWSLHHRYITSIQGANRAPAALQVRALRLHRNKACPALPAPTHLQAEPTR-- 627
Query: 375 QTHRAVRAL 383
T R VR +
Sbjct: 628 -TFRLVREM 635
>gi|239751443 PREDICTED: hypothetical protein [Homo sapiens]
Length = 783
Score = 44.7 bits (104), Expect = 2e-04
Identities = 55/189 (29%), Positives = 73/189 (38%), Gaps = 31/189 (16%)
Query: 214 GPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYAS 273
GP P Q+ Q+ H G + ++ + DSP P S W QL +
Sbjct: 459 GPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAG--GG 516
Query: 274 GGTEGFPLSRWA---PGRHGTAAEEGAQERPLPTDEMAPGR-GLWLGRLFGVPGGPAENE 329
G EG RWA PG G A G Q PLP E PG G L R GP +
Sbjct: 517 RGWEGRGAGRWARPGPGWDG-GARAGTQGLPLPGTEAEPGALGCSLSR------GPVPRQ 569
Query: 330 NGALKSR-------------RPSSWLPPTVSV--LALVKRGAPPEMPSPQELEASAPRMV 374
L +R + ++ P + V L L + A P +P+P L+A R
Sbjct: 570 GSLLSARVGWSLHHRYITSIQGANRAPAALQVRALRLHRNKACPALPAPTHLQAEPTR-- 627
Query: 375 QTHRAVRAL 383
T R VR +
Sbjct: 628 -TFRLVREM 635
>gi|239745948 PREDICTED: hypothetical protein XP_002343622 [Homo
sapiens]
Length = 791
Score = 44.7 bits (104), Expect = 2e-04
Identities = 55/189 (29%), Positives = 73/189 (38%), Gaps = 31/189 (16%)
Query: 214 GPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLTQASRVYAS 273
GP P Q+ Q+ H G + ++ + DSP P S W QL +
Sbjct: 467 GPGPWEQEERQSQAHHQGFVDGHPGSQARLWLALTWDSPPAPLQRSVWGQLQPQAG--GG 524
Query: 274 GGTEGFPLSRWA---PGRHGTAAEEGAQERPLPTDEMAPGR-GLWLGRLFGVPGGPAENE 329
G EG RWA PG G A G Q PLP E PG G L R GP +
Sbjct: 525 RGWEGRGAGRWARPGPGWDG-GARAGTQGLPLPGTEAEPGALGCSLSR------GPVPRQ 577
Query: 330 NGALKSR-------------RPSSWLPPTVSV--LALVKRGAPPEMPSPQELEASAPRMV 374
L +R + ++ P + V L L + A P +P+P L+A R
Sbjct: 578 GSLLSARVGWSLHHRYITSIQGANRAPAALQVRALRLHRNKACPALPAPTHLQAEPTR-- 635
Query: 375 QTHRAVRAL 383
T R VR +
Sbjct: 636 -TFRLVREM 643
>gi|61743942 abl-interactor 1 isoform a [Homo sapiens]
Length = 508
Score = 44.3 bits (103), Expect = 2e-04
Identities = 51/244 (20%), Positives = 84/244 (34%), Gaps = 34/244 (13%)
Query: 206 PPQAPAPPGPPPALQQTMQAMLHFGGRLAQSLRGTSKEAASDPSDSPNLPTPGSWWEQLT 265
PP + APP PP A + ++ G S GT S + + + + G + +
Sbjct: 279 PPPSGAPPAPPLAPLLPVSTVIAAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPS 338
Query: 266 QASRVYASGGTEGFPLSRWAPGRHGTAAEEGAQERPLPTDEMAPGRGLWLGRLFGVPGGP 325
++ A G PL + P P ++ P + G
Sbjct: 339 VTAQFSAQPHVNGGPLY--------SQNSISIAPPPPPMPQLTP--------QIPLTGFV 382
Query: 326 AENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTH-------- 377
A + S P PP + + PP P P + E +VQ +
Sbjct: 383 ARVQENIADSPTPPP--PPPPDDIPMFDDSPPPPPPPPVDYEDEEAAVVQYNDPYADGDP 440
Query: 378 --------RAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYT 429
V A+ D+T + D+LSF G ++ VI D+ W + + GL P Y
Sbjct: 441 AWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKNDDGWYEGVCNRVTGLFPGNYV 500
Query: 430 SLVL 433
++
Sbjct: 501 ESIM 504
>gi|4885153 v-crk sarcoma virus CT10 oncogene homolog (avian)-like
[Homo sapiens]
Length = 303
Score = 42.7 bits (99), Expect = 6e-04
Identities = 25/75 (33%), Positives = 35/75 (46%), Gaps = 4/75 (5%)
Query: 358 PEMPSPQELEASAPRMVQTH---RAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLR 414
P PSP SAP + VR L D + L F++GE+L +I +E W
Sbjct: 103 PRYPSPPMGSVSAPNLPTAEDNLEYVRTLYDFPGNDAEDLPFKKGEILVIIEKPEEQWWS 162
Query: 415 C-GRDGMEGLVPVGY 428
+DG G++PV Y
Sbjct: 163 ARNKDGRVGMIPVPY 177
>gi|109689723 abl interactor 2 [Homo sapiens]
Length = 475
Score = 42.7 bits (99), Expect = 6e-04
Identities = 28/107 (26%), Positives = 45/107 (42%), Gaps = 16/107 (14%)
Query: 343 PPTVSVLALVKRGAPPEMPSPQELEASAPRMVQTH----------------RAVRALCDH 386
PP V V +PP P P++ E +V+ V A+ D+
Sbjct: 365 PPPPPVEEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDY 424
Query: 387 TAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPVGYTSLVL 433
T + D+LSF+ G ++ VI D+ W +G+ GL P Y ++
Sbjct: 425 TKDKEDELSFQEGAIIYVIKKNDDGWYEGVMNGVTGLFPGNYVESIM 471
>gi|9910352 SH3-domain GRB2-like endophilin B2 [Homo sapiens]
Length = 395
Score = 42.4 bits (98), Expect = 8e-04
Identities = 41/120 (34%), Positives = 56/120 (46%), Gaps = 5/120 (4%)
Query: 315 LGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQELEASAPRMV 374
LGR G G E + L S P++ T+ V+ V APP S LE AP
Sbjct: 278 LGRFPGTFVGTTEPASPPLSSTSPTT-AAATMPVVPSVASLAPPGEASLC-LEEVAPPAS 335
Query: 375 QTHRAVRALCDHTAARPDQLSFRRGEVLRVITT--VDEDWLRCGRDGMEGLVPVGYTSLV 432
T +A R L D+ AA +L+ E++ V + +D DWL R +G VPV Y L+
Sbjct: 336 GTRKA-RVLYDYEAADSSELALLADELITVYSLPGMDPDWLIGERGNKKGKVPVTYLELL 394
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 42.4 bits (98), Expect = 8e-04
Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 361 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 420
P P E + S +V R +AL D D+LSF+ G+++ + +VD+DW+ G
Sbjct: 658 PCPAEAK-SMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGK 716
Query: 421 EGLVPVGY 428
G+ P Y
Sbjct: 717 SGIFPKNY 724
Score = 37.7 bits (86), Expect = 0.020
Identities = 17/44 (38%), Positives = 25/44 (56%)
Query: 382 ALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVP 425
AL TA D LSF+RG+ ++++ +D DW R EG+ P
Sbjct: 609 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFP 652
Score = 35.4 bits (80), Expect = 0.10
Identities = 20/78 (25%), Positives = 35/78 (44%), Gaps = 9/78 (11%)
Query: 358 PEMPSPQE--LEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRC 415
P PS + +++ AP V H D A + D L+ GE++ ++ +D DW R
Sbjct: 424 PNDPSHAQKPVDSGAPHAVVLH-------DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG 476
Query: 416 GRDGMEGLVPVGYTSLVL 433
G+ P Y +++
Sbjct: 477 NCRNQIGIFPANYVKVII 494
Score = 32.3 bits (72), Expect = 0.86
Identities = 19/66 (28%), Positives = 33/66 (50%), Gaps = 1/66 (1%)
Query: 367 EASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPV 426
E + V+ R V A ++ + D+LSF GE++ + V+E+W R G G+ P+
Sbjct: 505 ECVSSHCVKGSRCV-ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPL 563
Query: 427 GYTSLV 432
+ V
Sbjct: 564 NFVEPV 569
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 42.4 bits (98), Expect = 8e-04
Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 361 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 420
P P E + S +V R +AL D D+LSF+ G+++ + +VD+DW+ G
Sbjct: 694 PCPAEAK-SMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGK 752
Query: 421 EGLVPVGY 428
G+ P Y
Sbjct: 753 SGIFPKNY 760
Score = 37.7 bits (86), Expect = 0.020
Identities = 17/44 (38%), Positives = 25/44 (56%)
Query: 382 ALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVP 425
AL TA D LSF+RG+ ++++ +D DW R EG+ P
Sbjct: 645 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFP 688
Score = 35.4 bits (80), Expect = 0.10
Identities = 20/78 (25%), Positives = 35/78 (44%), Gaps = 9/78 (11%)
Query: 358 PEMPSPQE--LEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRC 415
P PS + +++ AP V H D A + D L+ GE++ ++ +D DW R
Sbjct: 460 PNDPSHAQKPVDSGAPHAVVLH-------DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG 512
Query: 416 GRDGMEGLVPVGYTSLVL 433
G+ P Y +++
Sbjct: 513 NCRNQIGIFPANYVKVII 530
Score = 32.3 bits (72), Expect = 0.86
Identities = 19/66 (28%), Positives = 33/66 (50%), Gaps = 1/66 (1%)
Query: 367 EASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPV 426
E + V+ R V A ++ + D+LSF GE++ + V+E+W R G G+ P+
Sbjct: 541 ECVSSHCVKGSRCV-ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPL 599
Query: 427 GYTSLV 432
+ V
Sbjct: 600 NFVEPV 605
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 42.4 bits (98), Expect = 8e-04
Identities = 22/68 (32%), Positives = 35/68 (51%), Gaps = 1/68 (1%)
Query: 361 PSPQELEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGM 420
P P E + S +V R +AL D D+LSF+ G+++ + +VD+DW+ G
Sbjct: 717 PCPAEAK-SMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGK 775
Query: 421 EGLVPVGY 428
G+ P Y
Sbjct: 776 SGIFPKNY 783
Score = 37.7 bits (86), Expect = 0.020
Identities = 17/44 (38%), Positives = 25/44 (56%)
Query: 382 ALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVP 425
AL TA D LSF+RG+ ++++ +D DW R EG+ P
Sbjct: 668 ALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFP 711
Score = 35.4 bits (80), Expect = 0.10
Identities = 20/78 (25%), Positives = 35/78 (44%), Gaps = 9/78 (11%)
Query: 358 PEMPSPQE--LEASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRC 415
P PS + +++ AP V H D A + D L+ GE++ ++ +D DW R
Sbjct: 483 PNDPSHAQKPVDSGAPHAVVLH-------DFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG 535
Query: 416 GRDGMEGLVPVGYTSLVL 433
G+ P Y +++
Sbjct: 536 NCRNQIGIFPANYVKVII 553
Score = 32.3 bits (72), Expect = 0.86
Identities = 19/66 (28%), Positives = 33/66 (50%), Gaps = 1/66 (1%)
Query: 367 EASAPRMVQTHRAVRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRDGMEGLVPV 426
E + V+ R V A ++ + D+LSF GE++ + V+E+W R G G+ P+
Sbjct: 564 ECVSSHCVKGSRCV-ARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPL 622
Query: 427 GYTSLV 432
+ V
Sbjct: 623 NFVEPV 628
>gi|222446607 SH3 domain containing ring finger 2 [Homo sapiens]
Length = 729
Score = 41.6 bits (96), Expect = 0.001
Identities = 31/134 (23%), Positives = 56/134 (41%), Gaps = 19/134 (14%)
Query: 306 EMAPGRGLWLGRLFGVPGGPAENENGALKSRRPSSWLPPTVSVLALVKRGAPPEMPSPQE 365
E P L + L GV G + G+ RRP + + + +P+
Sbjct: 61 EALPANLLLVRLLDGVRSGQSSGRGGSF--RRPGT----------MTLQDGRKSRTNPRR 108
Query: 366 LEASAPRMVQTHRA-------VRALCDHTAARPDQLSFRRGEVLRVITTVDEDWLRCGRD 418
L+AS R+V R +ALC++ P L F +G+++ + +DE+W + +
Sbjct: 109 LQASPFRLVPNVRIHMDGVPRAKALCNYRGQNPGDLRFNKGDIILLRRQLDENWYQGEIN 168
Query: 419 GMEGLVPVGYTSLV 432
G+ G P ++
Sbjct: 169 GISGNFPASSVEVI 182
Score = 30.4 bits (67), Expect = 3.3
Identities = 13/33 (39%), Positives = 21/33 (63%)
Query: 382 ALCDHTAARPDQLSFRRGEVLRVITTVDEDWLR 414
AL ++A PD+L ++GE +RV+ + WLR
Sbjct: 387 ALHSYSAHGPDELDLQKGEGVRVLGKCQDGWLR 419
>gi|44662836 breast cancer anti-estrogen resistance 1 [Homo sapiens]
Length = 870
Score = 40.8 bits (94), Expect = 0.002
Identities = 19/48 (39%), Positives = 30/48 (62%), Gaps = 3/48 (6%)
Query: 381 RALCDHTAARPDQLSFRRGEVLRVI---TTVDEDWLRCGRDGMEGLVP 425
+AL D+ A PD+LSFR+G+++ V+ T + W C G +G+VP
Sbjct: 9 KALYDNVAESPDELSFRKGDIMTVLEQDTQGLDGWWLCSLHGRQGIVP 56
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.407
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,768,896
Number of Sequences: 37866
Number of extensions: 1090609
Number of successful extensions: 10738
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 295
Number of HSP's that attempted gapping in prelim test: 8754
Number of HSP's gapped (non-prelim): 2157
length of query: 433
length of database: 18,247,518
effective HSP length: 105
effective length of query: 328
effective length of database: 14,271,588
effective search space: 4681080864
effective search space used: 4681080864
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.