Guide to the Human Genome
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Search of human proteins with 41872572

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
         (909 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]          1899   0.0  
gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]          1889   0.0  
gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]          1887   0.0  
gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]          1694   0.0  
gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]          1692   0.0  
gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]          1144   0.0  
gi|182508169 neuropilin 1 isoform a [Homo sapiens]                    813   0.0  
gi|66912178 neuropilin 1 isoform b [Homo sapiens]                     644   0.0  
gi|66864913 neuropilin 1 isoform c [Homo sapiens]                     644   0.0  
gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Ho...   190   5e-48
gi|31317224 EGF-like repeats and discoidin I-like domains-contai...   172   2e-42
gi|4503647 coagulation factor VIII isoform a precursor [Homo sap...   164   3e-40
gi|6912724 tolloid-like 2 [Homo sapiens]                              155   2e-37
gi|22547221 tolloid-like 1 [Homo sapiens]                             152   1e-36
gi|105990535 coagulation factor V precursor [Homo sapiens]            151   2e-36
gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Hom...   151   3e-36
gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Hom...   150   5e-36
gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Hom...   150   5e-36
gi|126091152 cubilin [Homo sapiens]                                   145   1e-34
gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]      140   4e-33
gi|72384339 CUB domain containing protein 2 [Homo sapiens]            137   6e-32
gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]      131   3e-30
gi|10518506 coagulation factor VIII isoform b precursor [Homo sa...   128   3e-29
gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo sa...   128   3e-29
gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Ho...   125   1e-28
gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Ho...   124   3e-28
gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3 pre...   113   9e-25
gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2 pre...   113   9e-25
gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo sap...   110   8e-24
gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo sa...   110   8e-24

>gi|41872572 neuropilin 2 isoform 3 precursor [Homo sapiens]
          Length = 909

 Score = 1899 bits (4920), Expect = 0.0
 Identities = 909/909 (100%), Positives = 909/909 (100%)

Query: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60
           MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY
Sbjct: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60

Query: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120
           APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML
Sbjct: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120

Query: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180
           YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL
Sbjct: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180

Query: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240
           AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS
Sbjct: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240

Query: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300
           STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS
Sbjct: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300

Query: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360
           DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS
Sbjct: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360

Query: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420
           YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL
Sbjct: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420

Query: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480
           RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ
Sbjct: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480

Query: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540
           AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD
Sbjct: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540

Query: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600
           PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT
Sbjct: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600

Query: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660
           VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD
Sbjct: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660

Query: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720
           HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY
Sbjct: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720

Query: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780
           QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR
Sbjct: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780

Query: 781 SGEIAIDDIRISTDVPLENCMEPISAFADEYEVDWSNSSSATSGSGAPSTDKEKSWLYTL 840
           SGEIAIDDIRISTDVPLENCMEPISAFADEYEVDWSNSSSATSGSGAPSTDKEKSWLYTL
Sbjct: 781 SGEIAIDDIRISTDVPLENCMEPISAFADEYEVDWSNSSSATSGSGAPSTDKEKSWLYTL 840

Query: 841 DPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKM 900
           DPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKM
Sbjct: 841 DPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYDGLKHKVKM 900

Query: 901 NHQKCCSEA 909
           NHQKCCSEA
Sbjct: 901 NHQKCCSEA 909


>gi|41872533 neuropilin 2 isoform 2 precursor [Homo sapiens]
          Length = 926

 Score = 1889 bits (4892), Expect = 0.0
 Identities = 909/926 (98%), Positives = 909/926 (98%), Gaps = 17/926 (1%)

Query: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60
           MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY
Sbjct: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60

Query: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120
           APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML
Sbjct: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120

Query: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180
           YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL
Sbjct: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180

Query: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240
           AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS
Sbjct: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240

Query: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300
           STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS
Sbjct: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300

Query: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360
           DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS
Sbjct: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360

Query: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420
           YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL
Sbjct: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420

Query: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480
           RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ
Sbjct: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480

Query: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540
           AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD
Sbjct: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540

Query: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600
           PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT
Sbjct: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600

Query: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660
           VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD
Sbjct: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660

Query: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720
           HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY
Sbjct: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720

Query: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780
           QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR
Sbjct: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780

Query: 781 SGEIAIDDIRISTDVPLENCMEPISAFA-----------------DEYEVDWSNSSSATS 823
           SGEIAIDDIRISTDVPLENCMEPISAFA                 DEYEVDWSNSSSATS
Sbjct: 781 SGEIAIDDIRISTDVPLENCMEPISAFAVDIPEIHEREGYEDEIDDEYEVDWSNSSSATS 840

Query: 824 GSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTL 883
           GSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTL
Sbjct: 841 GSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTL 900

Query: 884 ENYNFELYDGLKHKVKMNHQKCCSEA 909
           ENYNFELYDGLKHKVKMNHQKCCSEA
Sbjct: 901 ENYNFELYDGLKHKVKMNHQKCCSEA 926


>gi|41872562 neuropilin 2 isoform 1 precursor [Homo sapiens]
          Length = 931

 Score = 1887 bits (4887), Expect = 0.0
 Identities = 909/931 (97%), Positives = 909/931 (97%), Gaps = 22/931 (2%)

Query: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60
           MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY
Sbjct: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60

Query: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120
           APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML
Sbjct: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120

Query: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180
           YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL
Sbjct: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180

Query: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240
           AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS
Sbjct: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240

Query: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300
           STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS
Sbjct: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300

Query: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360
           DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS
Sbjct: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360

Query: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420
           YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL
Sbjct: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420

Query: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480
           RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ
Sbjct: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480

Query: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540
           AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD
Sbjct: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540

Query: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600
           PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT
Sbjct: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600

Query: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660
           VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD
Sbjct: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660

Query: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720
           HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY
Sbjct: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720

Query: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780
           QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR
Sbjct: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780

Query: 781 SGEIAIDDIRISTDVPLENCMEPISAFA----------------------DEYEVDWSNS 818
           SGEIAIDDIRISTDVPLENCMEPISAFA                      DEYEVDWSNS
Sbjct: 781 SGEIAIDDIRISTDVPLENCMEPISAFAGENFKVDIPEIHEREGYEDEIDDEYEVDWSNS 840

Query: 819 SSATSGSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSR 878
           SSATSGSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSR
Sbjct: 841 SSATSGSGAPSTDKEKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSR 900

Query: 879 SCTTLENYNFELYDGLKHKVKMNHQKCCSEA 909
           SCTTLENYNFELYDGLKHKVKMNHQKCCSEA
Sbjct: 901 SCTTLENYNFELYDGLKHKVKMNHQKCCSEA 931


>gi|41872544 neuropilin 2 isoform 4 precursor [Homo sapiens]
          Length = 906

 Score = 1694 bits (4386), Expect = 0.0
 Identities = 809/810 (99%), Positives = 809/810 (99%)

Query: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60
           MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY
Sbjct: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60

Query: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120
           APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML
Sbjct: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120

Query: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180
           YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL
Sbjct: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180

Query: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240
           AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS
Sbjct: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240

Query: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300
           STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS
Sbjct: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300

Query: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360
           DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS
Sbjct: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360

Query: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420
           YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL
Sbjct: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420

Query: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480
           RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ
Sbjct: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480

Query: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540
           AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD
Sbjct: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540

Query: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600
           PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT
Sbjct: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600

Query: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660
           VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD
Sbjct: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660

Query: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720
           HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY
Sbjct: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720

Query: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780
           QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR
Sbjct: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780

Query: 781 SGEIAIDDIRISTDVPLENCMEPISAFADE 810
           SGEIAIDDIRISTDVPLENCMEPISAFA E
Sbjct: 781 SGEIAIDDIRISTDVPLENCMEPISAFAGE 810


>gi|41872567 neuropilin 2 isoform 5 precursor [Homo sapiens]
          Length = 901

 Score = 1692 bits (4382), Expect = 0.0
 Identities = 808/808 (100%), Positives = 808/808 (100%)

Query: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60
           MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY
Sbjct: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60

Query: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120
           APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML
Sbjct: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120

Query: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180
           YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL
Sbjct: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180

Query: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240
           AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS
Sbjct: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240

Query: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300
           STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS
Sbjct: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300

Query: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360
           DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS
Sbjct: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360

Query: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420
           YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL
Sbjct: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420

Query: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480
           RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ
Sbjct: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480

Query: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540
           AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD
Sbjct: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540

Query: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600
           PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT
Sbjct: 541 PRTQQPKLFEGNMHYDTPDIRRFDPIPAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPT 600

Query: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660
           VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD
Sbjct: 601 VETLGPTVKSEETTTPYPTEEEATECGENCSFEDDKDLQLPSGFNCNFDFLEEPCGWMYD 660

Query: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720
           HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY
Sbjct: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720

Query: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780
           QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR
Sbjct: 721 QATGGRGVALQVVREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIGKGR 780

Query: 781 SGEIAIDDIRISTDVPLENCMEPISAFA 808
           SGEIAIDDIRISTDVPLENCMEPISAFA
Sbjct: 781 SGEIAIDDIRISTDVPLENCMEPISAFA 808


>gi|41872557 neuropilin 2 isoform 6 precursor [Homo sapiens]
          Length = 555

 Score = 1144 bits (2958), Expect = 0.0
 Identities = 547/548 (99%), Positives = 548/548 (100%)

Query: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60
           MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY
Sbjct: 1   MDMFPLTWVFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60

Query: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120
           APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML
Sbjct: 61  APEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSML 120

Query: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180
           YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL
Sbjct: 121 YIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTIL 180

Query: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240
           AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS
Sbjct: 181 AKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRS 240

Query: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300
           STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS
Sbjct: 241 STGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYS 300

Query: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360
           DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS
Sbjct: 301 DGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISRETQNGYYVKS 360

Query: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420
           YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL
Sbjct: 361 YKLEVSTNGEDWMVYRHGKNHKVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIAL 420

Query: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480
           RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ
Sbjct: 421 RLELFGCRVTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVSSRSGWFPRIPQ 480

Query: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540
           AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD
Sbjct: 481 AQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQD 540

Query: 541 PRTQQPKL 548
           PRTQQPK+
Sbjct: 541 PRTQQPKV 548



 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 63/203 (31%), Positives = 103/203 (50%), Gaps = 21/203 (10%)

Query: 413 TWHSGIALRLELFGCR--------VTDAPCSNMLGMLSGLIADSQISASST-QEYLWSPS 463
           T+H+ +A+  + F  R        + +  C+  LGM SG IA+ QISASST  +  W+P 
Sbjct: 248 TFHTDMAVAKDGFSARYYLVHQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQ 307

Query: 464 AARLVSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRK 523
            +RL    +GW P +      +E+LQVDL     +  +  QGA   ++        +V+ 
Sbjct: 308 QSRLHGDDNGWTPNLDS---NKEYLQVDLRFLTMLTAIATQGAISRETQNGY----YVKS 360

Query: 524 FKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAG 582
           +K+  S NG+DW   +  +    K+F+ N       + +   P+  ++VR+ P+ W  +G
Sbjct: 361 YKLEVSTNGEDWMVYRHGKNH--KVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWH-SG 417

Query: 583 IGMRLEVLGCDWTDSKPTVETLG 605
           I +RLE+ GC  TD+ P    LG
Sbjct: 418 IALRLELFGCRVTDA-PCSNMLG 439


>gi|182508169 neuropilin 1 isoform a [Homo sapiens]
          Length = 923

 Score =  813 bits (2099), Expect = 0.0
 Identities = 419/918 (45%), Positives = 583/918 (63%), Gaps = 57/918 (6%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86

Query: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146

Query: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205

Query: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265

Query: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324

Query: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384

Query: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444

Query: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503

Query: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566
           +        E + F+RKFK+ YS NG DW+ I D   ++ K FEGN +YDTP++R F  +
Sbjct: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557

Query: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATEC 626
             +++R+YPER +  G+G+R+E+LGC+         T GPT  +          +E  + 
Sbjct: 558 STRFIRIYPERATHGGLGLRMELLGCE-----VEAPTAGPTTPNGNLV------DECDDD 606

Query: 627 GENCSFEDDKDLQLPS------------------------GFNCNFDFLEEP--CGWMYD 660
             NC      D QL                          GFNC F +      C W +D
Sbjct: 607 QANCHSGTGDDFQLTGGTTVLATEKPTVIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHD 666

Query: 661 HAKWLRTTWASSSSPNDRTFPDDRNFLRLQSDSQREGQYARLISPPVHLPRSPVCMEFQY 720
           +   L+ +  +S +   +    D NF+  Q+D  ++G+ ARL+SP V+   S  CM F Y
Sbjct: 667 NHVQLKWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQNSAHCMTFWY 726

Query: 721 QATGGRGVALQV---VREASQESKLLWVIREDQGGEWKHGRIILPSYDMEYQIVFEGVIG 777
             +G     L+V    ++  +  +L+W+    QG  WK GR++L      YQ++FEG IG
Sbjct: 727 HMSGSHVGTLRVKLRYQKPEEYDQLVWMAIGHQGDHWKEGRVLLHKSLKLYQVIFEGEIG 786

Query: 778 KGRSGEIAIDDIRISTDVPLENCMEP--ISAFADEYEVDWSNSSSATSGSGAPSTD---K 832
           KG  G IA+DDI I+  +  E+C +P  +     E ++D + S+    G G    +   K
Sbjct: 787 KGNLGGIAVDDISINNHISQEDCAKPADLDKKNPEIKIDETGSTPGYEGEGEGDKNISRK 846

Query: 833 EKSWLYTLDPILITIIAMSSLGVLLGATCAGLLLYCTCSYSGLSSRSCTTLENYNFELYD 892
             + L TLDPILITIIAMS+LGVLLGA C G++LYC C ++G+S R+ + LENYNFEL D
Sbjct: 847 PGNVLKTLDPILITIIAMSALGVLLGAVC-GVVLYCACWHNGMSERNLSALENYNFELVD 905

Query: 893 GLK-HKVKMNHQKCCSEA 909
           G+K  K K+N Q   SEA
Sbjct: 906 GVKLKKDKLNTQSTYSEA 923


>gi|66912178 neuropilin 1 isoform b [Homo sapiens]
          Length = 644

 Score =  644 bits (1662), Expect = 0.0
 Identities = 308/617 (49%), Positives = 423/617 (68%), Gaps = 21/617 (3%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86

Query: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146

Query: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205

Query: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265

Query: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324

Query: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384

Query: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444

Query: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503

Query: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566
           +        E + F+RKFK+ YS NG DW+ I D   ++ K FEGN +YDTP++R F  +
Sbjct: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557

Query: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTVKSEETTTPYPTEEEATEC 626
             +++R+YPER +  G+G+R+E+LGC+         T GPT  +          +E  + 
Sbjct: 558 STRFIRIYPERATHGGLGLRMELLGCE-----VEAPTAGPTTPNGNLV------DECDDD 606

Query: 627 GENCSFEDDKDLQLPSG 643
             NC      D QL  G
Sbjct: 607 QANCHSGTGDDFQLTGG 623


>gi|66864913 neuropilin 1 isoform c [Homo sapiens]
          Length = 609

 Score =  644 bits (1660), Expect = 0.0
 Identities = 301/582 (51%), Positives = 414/582 (71%), Gaps = 10/582 (1%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CG  +  +  GY+TSPGYP  Y   + CEW++ AP+P Q+I++NFNPHF++E  DCKYD+
Sbjct: 27  CGDTIKIESPGYLTSPGYPHSYHPSEKCEWLIQAPDPYQRIMINFNPHFDLEDRDCKYDY 86

Query: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
           +E+ DG++E+    GK CG IAPP ++SSG  L+IKF SDY   GAGFS+RYEIFK G E
Sbjct: 87  VEVFDGENENGHFRGKFCGKIAPPPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPE 146

Query: 148 DCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
            CS+N+T+P+G I+SPGFPEKYP++L+CT+ + A    EIIL+F  FDLE D    G   
Sbjct: 147 -CSQNYTTPSGVIKSPGFPEKYPNSLECTYIVFAPKMSEIILEFESFDLEPDSNPPGGMF 205

Query: 208 CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
           C+YD L+IWDG P VGP IG+YCG KTP  +RSS+GILS+ F+TD A+AK+GFSA Y ++
Sbjct: 206 CRYDRLEIWDGFPDVGPHIGRYCGQKTPGRIRSSSGILSMVFYTDSAIAKEGFSANYSVL 265

Query: 268 HQEPLENFQCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLHGDDNGWTPNLDSNKE 327
                E+F+C   LGMESG I ++QI+ASS YS   W+ ++SRL+  +NGWTP  DS +E
Sbjct: 266 QSSVSEDFKCMEALGMESGEIHSDQITASSQYSTN-WSAERSRLNYPENGWTPGEDSYRE 324

Query: 328 YLQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQAN 387
           ++QVDL  L  +TA+ TQGAIS+ET+  YYVK+YK++VS+NGEDW+  + G    +FQ N
Sbjct: 325 WIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYKIDVSSNGEDWITIKEGNKPVLFQGN 384

Query: 388 NDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIAD 447
            + T+VV+     PL+TRFVRI+P TW +GI++R E++GC++TD PCS MLGM+SGLI+D
Sbjct: 385 TNPTDVVVAVFPKPLITRFVRIKPATWETGISMRFEVYGCKITDYPCSGMLGMVSGLISD 444

Query: 448 SQISASSTQEYLWSPSAARLVSSRSGW-FPRIPQAQPGEEWLQVDLGTPKTVKGVIIQGA 506
           SQI++S+  +  W P   RLV+SRSGW  P  P +    EWLQ+DLG  K V+G+IIQG 
Sbjct: 445 SQITSSNQGDRNWMPENIRLVTSRSGWALPPAPHSYI-NEWLQIDLGEEKIVRGIIIQGG 503

Query: 507 RGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRRFDPI 566
           +        E + F+RKFK+ YS NG DW+ I D   ++ K FEGN +YDTP++R F  +
Sbjct: 504 KHR------ENKVFMRKFKIGYSNNGSDWKMIMDDSKRKAKSFEGNNNYDTPELRTFPAL 557

Query: 567 PAQYVRVYPERWSPAGIGMRLEVLGCDWTDSKPTVETLGPTV 608
             +++R+YPER +  G+G+R+E+LGC+       + T  PTV
Sbjct: 558 STRFIRIYPERATHGGLGLRMELLGCEVEGGTTVLATEKPTV 599


>gi|167830475 milk fat globule-EGF factor 8 protein isoform a [Homo
           sapiens]
          Length = 387

 Score =  190 bits (483), Expect = 5e-48
 Identities = 120/331 (36%), Positives = 181/331 (54%), Gaps = 26/331 (7%)

Query: 276 QCNVPLGMESGRIANEQISASSTYSD----GRWTPQQSRLH--GDDNGWTPNLDSNKEYL 329
           +C  PLG+E+G IAN QI+ASS          W P+ +RL+  G  N WTP+ + +  ++
Sbjct: 69  KCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWI 128

Query: 330 QVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDW-MVYRHGKNHKVFQANN 388
           QV+L     +T + TQGA    +    Y+K++K+  S NG ++  ++   K HK F  N 
Sbjct: 129 QVNLLRRMWVTGVVTQGASRLASHE--YLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNW 186

Query: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
           +   V +N    P+  ++VR+ P + H+   LR EL GC +    C+N LG+ +  I D 
Sbjct: 187 NKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNG--CANPLGLKNNSIPDK 244

Query: 449 QISASSTQE------YLWSPSAARLVSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
           QI+ASS+ +      + W+PS ARL   +  +   +  +   ++WLQVDLG+ K V G+I
Sbjct: 245 QITASSSYKTWGLHLFSWNPSYARL-DKQGNFNAWVAGSYGNDQWLQVDLGSSKEVTGII 303

Query: 503 IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRR 562
            QGAR   S+       FV  +KV+YS +  +W   QDPRT   K+F GN    +     
Sbjct: 304 TQGARNFGSV------QFVASYKVAYSNDSANWTEYQDPRTGSSKIFPGNWDNHSHKKNL 357

Query: 563 FD-PIPAQYVRVYPERWSPAGIGMRLEVLGC 592
           F+ PI A+YVR+ P  W    I +RLE+LGC
Sbjct: 358 FETPILARYVRILPVAWHNR-IALRLELLGC 387



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 59/170 (34%), Positives = 93/170 (54%), Gaps = 17/170 (10%)

Query: 431 DAPCSNMLGMLSGLIADSQISASSTQEYL-----WSPSAARLVSSRSGWFPR-IPQAQPG 484
           +  C   LG+ +G IA+SQI+ASS +        W P  ARL  +R+G      P +   
Sbjct: 67  ETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARL--NRAGMVNAWTPSSNDD 124

Query: 485 EEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQ 544
             W+QV+L     V GV+ QGA      + + +  +++ FKV+YSLNG ++++I D   +
Sbjct: 125 NPWIQVNLLRRMWVTGVVTQGA------SRLASHEYLKAFKVAYSLNGHEFDFIHDV-NK 177

Query: 545 QPKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
           + K F GN + +   +  F+ P+ AQYVR+YP     A   +R E+LGC+
Sbjct: 178 KHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTA-CTLRFELLGCE 226


>gi|31317224 EGF-like repeats and discoidin I-like
           domains-containing protein 3 [Homo sapiens]
          Length = 480

 Score =  172 bits (435), Expect = 2e-42
 Identities = 117/335 (34%), Positives = 175/335 (52%), Gaps = 31/335 (9%)

Query: 275 FQCNVPLGMESGRIANEQISASSTYSD----GRWTPQQSRLH--GDDNGWTPNLDSNKEY 328
           ++C+ PLG+E G I+N+QI+ASST+       +W P  +RL+  G  N WT   +    +
Sbjct: 156 YKCSGPLGIEGGIISNQQITASSTHRALFGLQKWYPYYARLNKKGLINAWTAAENDRWPW 215

Query: 329 LQVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYR-HGKNHK-VFQA 386
           +Q++L+    +T + TQGA  +   +  Y+KSYK+  S +G+ W +Y+  G N   VF+ 
Sbjct: 216 IQINLQRKMRVTGVITQGA--KRIGSPEYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRG 273

Query: 387 NNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIA 446
           N D      N    P+  ++VR+ PQ       LR+EL GC ++   CS  LGM SG I 
Sbjct: 274 NIDNNTPYANSFTPPIKAQYVRLYPQVCRRHCTLRMELLGCELSG--CSEPLGMKSGHIQ 331

Query: 447 DSQISASST------QEYLWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTV 498
           D QI+ASS         + W P  ARL      + W           +WLQVDL  P  V
Sbjct: 332 DYQITASSIFRTLNMDMFTWEPRKARLDKQGKVNAW---TSGHNDQSQWLQVDLLVPTKV 388

Query: 499 KGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTP 558
            G+I QGA+    +       FV  +K++YS +G+ W   QD + ++ K+F+GN   DT 
Sbjct: 389 TGIITQGAKDFGHVQ------FVGSYKLAYSNDGEHWTVYQDEKQRKDKVFQGNFDNDTH 442

Query: 559 DIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGC 592
                D PI A+++R+ P  W    I +R E+LGC
Sbjct: 443 RKNVIDPPIYARHIRILPWSWY-GRITLRSELLGC 476


>gi|4503647 coagulation factor VIII isoform a precursor [Homo sapiens]
          Length = 2351

 Score =  164 bits (415), Expect = 3e-40
 Identities = 117/334 (35%), Positives = 176/334 (52%), Gaps = 36/334 (10%)

Query: 276  QCNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNLDSNKE---YLQ 330
            +C  PLGM SG I + QI+AS  Y  G+W P+ +RLH  G  N W     S KE   +++
Sbjct: 2039 KCQTPLGMASGHIRDFQITASGQY--GQWAPKLARLHYSGSINAW-----STKEPFSWIK 2091

Query: 331  VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHK--VFQANN 388
            VDL    ++  I TQGA  R+  +  Y+  + +  S +G+ W  YR        VF  N 
Sbjct: 2092 VDLLAPMIIHGIKTQGA--RQKFSSLYISQFIIMYSLDGKKWQTYRGNSTGTLMVFFGNV 2149

Query: 389  DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
            D++ +  N  + P++ R++R+ P  +     LR+EL GC +    CS  LGM S  I+D+
Sbjct: 2150 DSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGMESKAISDA 2207

Query: 449  QISASS---TQEYLWSPSAARL-VSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVIIQ 504
            QI+ASS        WSPS ARL +  RS  +   PQ    +EWLQVD      V GV  Q
Sbjct: 2208 QITASSYFTNMFATWSPSKARLHLQGRSNAWR--PQVNNPKEWLQVDFQKTMKVTGVTTQ 2265

Query: 505  GARGGDSITAVEARAFVRKFKVSYSLNGKDWE-YIQDPRTQQPKLFEGNMHYDTPDIRRF 563
            G      + ++    +V++F +S S +G  W  + Q+ +    K+F+GN    TP +   
Sbjct: 2266 G------VKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV---KVFQGNQDSFTPVVNSL 2316

Query: 564  D-PIPAQYVRVYPERWSPAGIGMRLEVLGCDWTD 596
            D P+  +Y+R++P+ W    I +R+EVLGC+  D
Sbjct: 2317 DPPLLTRYLRIHPQSWVHQ-IALRMEVLGCEAQD 2349


>gi|6912724 tolloid-like 2 [Homo sapiens]
          Length = 1015

 Score =  155 bits (391), Expect = 2e-37
 Identities = 93/276 (33%), Positives = 140/276 (50%), Gaps = 47/276 (17%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG +N KDAG I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 464 CGGDMN-KDAGQIQSPNYPDDYRPSKECVWRITVSE-GFHVGLTFQA-FEIERHDSCAYD 520

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY--EIFKT 144
           ++E+RDG +E + L+G  CG   P  + SS + L++KF SD +   AGF+  +  E+ + 
Sbjct: 521 YLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANFFKEVDEC 580

Query: 145 GSED-----------------------------------CSKNFTSPNGTIESPGFPEKY 169
              D                                   C    T  NGTI SPG+P++Y
Sbjct: 581 SWPDHGGCEHRCVNTLGSYKCACDPGYELAADKKMCEVACGGFITKLNGTITSPGWPKEY 640

Query: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
           P N +C + ++A  +  I LQF +F+LE      G   CKYD++++  G+     L G++
Sbjct: 641 PTNKNCVWQVVAPAQYRISLQFEVFELE------GNDVCKYDFVEVRSGLSPDAKLHGRF 694

Query: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
           CG++TP  + S +  + + F +D  V+K GF A ++
Sbjct: 695 CGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFF 730



 Score =  146 bits (368), Expect = 1e-34
 Identities = 80/241 (33%), Positives = 126/241 (52%), Gaps = 16/241 (6%)

Query: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
           P CG  L     G  ++PG+P  YPS+ +C W + +  P +KIVLNF      +   C Y
Sbjct: 349 PACGETLQDT-TGNFSAPGFPNGYPSYSHCVWRI-SVTPGEKIVLNFTSMDLFKSRLCWY 406

Query: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
           D++E+RDG    A LLG+ CG+  P  ++S+ S L+++F S     G GF   YE     
Sbjct: 407 DYVEVRDGYWRKAPLLGRFCGDKIPEPLVSTDSRLWVEFRSSSNILGKGFFAAYE----- 461

Query: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
              C  +     G I+SP +P+ Y  + +C + I       + L F  F++E HD     
Sbjct: 462 -ATCGGDMNKDAGQIQSPNYPDDYRPSKECVWRITVSEGFHVGLTFQAFEIERHD----- 515

Query: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
              C YD+L++ DG      LIG +CG + P +++SS+  L + F +D ++ K GF+A +
Sbjct: 516 --SCAYDYLEVRDGPTEESALIGHFCGYEKPEDVKSSSNRLWMKFVSDGSINKAGFAANF 573

Query: 265 Y 265
           +
Sbjct: 574 F 574



 Score =  142 bits (358), Expect = 1e-33
 Identities = 87/273 (31%), Positives = 136/273 (49%), Gaps = 47/273 (17%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG + +K  G ITSPG+P++YP+++NC W V AP    +I L F   FE+E +D CKYD
Sbjct: 620 CGGFI-TKLNGTITSPGWPKEYPTNKNCVWQVVAPA-QYRISLQFEV-FELEGNDVCKYD 676

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLR-------- 138
           F+E+R G S  A L G+ CG+  P  I S  + + ++F SD      GF           
Sbjct: 677 FVEVRSGLSPDAKLHGRFCGSETPEVITSQSNNMRVEFKSDNTVSKRGFRAHFFSDKDEC 736

Query: 139 -------------------------YEIFKTGSE----DCSKNFTSPNGTIESPGFPEKY 169
                                    Y + + G +     C+   +S  GT+ SP +P+KY
Sbjct: 737 AKDNGGCQHECVNTFGSYLCRCRNGYWLHENGHDCKEAGCAHKISSVEGTLASPNWPDKY 796

Query: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
           P   +CT+ I +     + L F  F++E         +C YD L+++DG   + P++G++
Sbjct: 797 PSRRECTWNISSTAGHRVKLTFNEFEIEQ------HQECAYDHLEMYDGPDSLAPILGRF 850

Query: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSA 262
           CG+K P    +S   + L F++D +V + GF A
Sbjct: 851 CGSKKPDPTVASGSSMFLRFYSDASVQRKGFQA 883



 Score =  129 bits (324), Expect = 1e-29
 Identities = 76/242 (31%), Positives = 123/242 (50%), Gaps = 20/242 (8%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DCKYD 86
            C  +++S + G + SP +P  YPS + C W + +     ++ L FN  FEIE+H +C YD
Sbjct: 776  CAHKISSVE-GTLASPNWPDKYPSRRECTWNI-SSTAGHRVKLTFN-EFEIEQHQECAYD 832

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
             +E+ DG    A +LG+ CG+  P   ++SGS ++++F SD + Q  GF   +      S
Sbjct: 833  HLEMYDGPDSLAPILGRFCGSKKPDPTVASGSSMFLRFYSDASVQRKGFQAVH------S 886

Query: 147  EDCSKNFTSPNGTIESPGFPE----KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQ 202
             +C     +   T E     +     YP    C + I+A+    + L F  F++E     
Sbjct: 887  TECGGRLKAEVQTKELYSHAQFGDNNYPSEARCDWVIVAEDGYGVELTFRTFEVEE---- 942

Query: 203  VGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSA 262
              E DC YD+++ +DG     P +G++CG+    E+ S+   L + F TD  + K GF A
Sbjct: 943  --EADCGYDYMEAYDGYDSSAPRLGRFCGSGPLEEIYSAGDSLMIRFRTDDTINKKGFHA 1000

Query: 263  RY 264
            RY
Sbjct: 1001 RY 1002


>gi|22547221 tolloid-like 1 [Homo sapiens]
          Length = 1013

 Score =  152 bits (385), Expect = 1e-36
 Identities = 91/278 (32%), Positives = 136/278 (48%), Gaps = 51/278 (18%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG +  K+ G I SP YP DY   + C W +   E +  + L F   FEIE+HD C YD
Sbjct: 462 CGGEIR-KNEGQIQSPNYPDDYRPMKECVWKITVSE-SYHVGLTFQS-FEIERHDNCAYD 518

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
           ++E+RDG SE++ L+G+ CG   P  I S+ + L++KF SD     AGF+  +  FK   
Sbjct: 519 YLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF--FKEED 576

Query: 147 E---------------------------------------DCSKNFTSPNGTIESPGFPE 167
           E                                        C    T  NGTI +PG+P+
Sbjct: 577 ECAKPDRGGCEQRCLNTLGSYQCACEPGYELGPDRRSCEAACGGLLTKLNGTITTPGWPK 636

Query: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
           +YP N +C + ++A  +  I ++F  F+LE      G   CKYD+++IW G+     L G
Sbjct: 637 EYPPNKNCVWQVVAPTQYRISVKFEFFELE------GNEVCKYDYVEIWSGLSSESKLHG 690

Query: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
           K+CG + P  + S    + + F +D  V+K GF A ++
Sbjct: 691 KFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFF 728



 Score =  150 bits (379), Expect = 5e-36
 Identities = 85/246 (34%), Positives = 128/246 (52%), Gaps = 16/246 (6%)

Query: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
           P CG  L   + G ++SPG+P  YPS+ +C W V +  P +KIVLNF      +   C Y
Sbjct: 347 PACGETLQESN-GNLSSPGFPNGYPSYTHCIWRV-SVTPGEKIVLNFTTMDLYKSSLCWY 404

Query: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
           D+IE+RDG    + LLG+ CG+  P  + S+ S ++I+F S     G GF+  YE     
Sbjct: 405 DYIEVRDGYWRKSPLLGRFCGDKLPEVLTSTDSRMWIEFRSSSNWVGKGFAAVYEAI--- 461

Query: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
              C        G I+SP +P+ Y    +C + I       + L F  F++E HD     
Sbjct: 462 ---CGGEIRKNEGQIQSPNYPDDYRPMKECVWKITVSESYHVGLTFQSFEIERHD----- 513

Query: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
             +C YD+L++ DG     PLIG++CG   P ++RS++  L + F +D  V K GF+A +
Sbjct: 514 --NCAYDYLEVRDGTSENSPLIGRFCGYDKPEDIRSTSNTLWMKFVSDGTVNKAGFAANF 571

Query: 265 YLVHQE 270
           +    E
Sbjct: 572 FKEEDE 577



 Score =  142 bits (357), Expect = 2e-33
 Identities = 81/257 (31%), Positives = 140/257 (54%), Gaps = 23/257 (8%)

Query: 13   LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNF 72
            L+ ++H  +   +  C  +++S  +G ITSP +P  YPS + C W + A  P  +I L F
Sbjct: 762  LHDNKHDCK---EAECEQKIHSP-SGLITSPNWPDKYPSRKECTWEISAT-PGHRIKLAF 816

Query: 73   NPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQ 131
            +  FEIE+H +C YD +E+ DG++E + +LG+ CGN  P  ++++G+ ++++F SD + Q
Sbjct: 817  S-EFEIEQHQECAYDHLEVFDGETEKSPILGRLCGNKIPDPLVATGNKMFVRFVSDASVQ 875

Query: 132  GAGFSLRYEIFKTGSEDCS---KNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEI 187
              GF        T S +C    K  + P        F +  YP  +DC + ++++    +
Sbjct: 876  RKGFQ------ATHSTECGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVSERGSRL 929

Query: 188  ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSL 247
             L F  F++E       E DC YD+++++DG+      +G++CG+  P E+ S    + +
Sbjct: 930  ELSFQTFEVEE------EADCGYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLI 983

Query: 248  TFHTDMAVAKDGFSARY 264
             FHTD  + K GF  RY
Sbjct: 984  HFHTDDTINKKGFHIRY 1000



 Score =  135 bits (340), Expect = 2e-31
 Identities = 90/275 (32%), Positives = 133/275 (48%), Gaps = 47/275 (17%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG L +K  G IT+PG+P++YP ++NC W V AP    +I + F   FE+E ++ CKYD
Sbjct: 618 CGGLL-TKLNGTITTPGWPKEYPPNKNCVWQVVAPT-QYRISVKFE-FFELEGNEVCKYD 674

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY------- 139
           ++EI  G S  + L GK CG   P  I S  + + I+F SD      GF   +       
Sbjct: 675 YVEIWSGLSSESKLHGKFCGAEVPEVITSQFNNMRIEFKSDNTVSKKGFKAHFFSDKDEC 734

Query: 140 ---------EIFKT-GS--------------------EDCSKNFTSPNGTIESPGFPEKY 169
                    E   T GS                     +C +   SP+G I SP +P+KY
Sbjct: 735 SKDNGGCQHECVNTMGSYMCQCRNGFVLHDNKHDCKEAECEQKIHSPSGLITSPNWPDKY 794

Query: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
           P   +CT+ I A P   I L F  F++E         +C YD L+++DG     P++G+ 
Sbjct: 795 PSRKECTWEISATPGHRIKLAFSEFEIEQ------HQECAYDHLEVFDGETEKSPILGRL 848

Query: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
           CG K P  L ++   + + F +D +V + GF A +
Sbjct: 849 CGNKIPDPLVATGNKMFVRFVSDASVQRKGFQATH 883



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 40/117 (34%), Positives = 63/117 (53%), Gaps = 6/117 (5%)

Query: 28   CGGRLNSKDAG---YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DC 83
            CGGRL ++      Y  +     +YP   +CEW++ + E   ++ L+F   FE+E+  DC
Sbjct: 887  CGGRLKAESKPRDLYSHAQFGDNNYPGQVDCEWLLVS-ERGSRLELSFQT-FEVEEEADC 944

Query: 84   KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
             YD++E+ DG   +A  LG+ CG+  P  I S G  + I F +D      GF +RY+
Sbjct: 945  GYDYVELFDGLDSTAVGLGRFCGSGPPEEIYSIGDSVLIHFHTDDTINKKGFHIRYK 1001


>gi|105990535 coagulation factor V precursor [Homo sapiens]
          Length = 2224

 Score =  151 bits (382), Expect = 2e-36
 Identities = 101/333 (30%), Positives = 176/333 (52%), Gaps = 33/333 (9%)

Query: 277  CNVPLGMESGRIANEQISASSTYSDGRWTPQQSRLH--GDDNGWTPNL----DSNKEYLQ 330
            C +P+G+ +G I++ QI AS     G W P+ +RL+  G  N W+        ++K ++Q
Sbjct: 1907 CRMPMGLSTGIISDSQIKASEFL--GYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQ 1964

Query: 331  VDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKV--FQANN 388
            VD++   ++T I TQGA  +      Y   + +  S+N  +W +++      V  F  N+
Sbjct: 1965 VDMQKEVIITGIQTQGA--KHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNS 2022

Query: 389  DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
            DA+ +  N+   P++ R++RI P   ++   LRLEL GC V    CS  LGM +G I + 
Sbjct: 2023 DASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNG--CSTPLGMENGKIENK 2080

Query: 449  QISASSTQEY----LWSPSAARLVSSR--SGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
            QI+ASS ++      W P  ARL +    + W  +   A   ++WL++DL   K +  +I
Sbjct: 2081 QITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAK---ANNNKQWLEIDLLKIKKITAII 2137

Query: 503  IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRR 562
             QG +      ++ +  +V+ + + YS  G +W+  +   +   K+FEGN +     ++ 
Sbjct: 2138 TQGCK------SLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN-TKGHVKN 2190

Query: 563  F--DPIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
            F   PI ++++RV P+ W+ + I +RLE+ GCD
Sbjct: 2191 FFNPPIISRFIRVIPKTWNQS-IALRLELFGCD 2222



 Score =  122 bits (305), Expect = 2e-27
 Identities = 65/160 (40%), Positives = 100/160 (62%), Gaps = 9/160 (5%)

Query: 277  CNVPLGMESGRIANEQISASS---TYSDGRWTPQQSRLH--GDDNGWTPNLDSNKEYLQV 331
            C+ PLGME+G+I N+QI+ASS   ++    W P ++RL+  G  N W    ++NK++L++
Sbjct: 2066 CSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEI 2125

Query: 332  DLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKN--HKVFQANND 389
            DL  +  +TAI TQG  S  ++   YVKSY +  S  G +W  YR   +   K+F+ N +
Sbjct: 2126 DLLKIKKITAIITQGCKSLSSE--MYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTN 2183

Query: 390  ATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRV 429
                V N  + P+++RF+R+ P+TW+  IALRLELFGC +
Sbjct: 2184 TKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDI 2223



 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 52/169 (30%), Positives = 83/169 (49%), Gaps = 12/169 (7%)

Query: 429  VTDAPCSNMLGMLSGLIADSQISASSTQEYLWSPSAARLVS--SRSGW-FPRIPQAQPGE 485
            + D  C   +G+ +G+I+DSQI AS    Y W P  ARL +  S + W   ++      +
Sbjct: 1902 IMDRDCRMPMGLSTGIISDSQIKASEFLGY-WEPRLARLNNGGSYNAWSVEKLAAEFASK 1960

Query: 486  EWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
             W+QVD+     + G+  QGA+            +  +F V+YS N  +W+  +   T+ 
Sbjct: 1961 PWIQVDMQKEVIITGIQTQGAK------HYLKSCYTTEFYVAYSSNQINWQIFKGNSTRN 2014

Query: 546  PKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
               F GN    T    +FD PI A+Y+R+ P R +     +RLE+ GC+
Sbjct: 2015 VMYFNGNSDASTIKENQFDPPIVARYIRISPTR-AYNRPTLRLELQGCE 2062


>gi|5902808 bone morphogenetic protein 1 isoform 2 precursor [Homo
           sapiens]
          Length = 823

 Score =  151 bits (381), Expect = 3e-36
 Identities = 96/280 (34%), Positives = 142/280 (50%), Gaps = 51/280 (18%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549

Query: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609

Query: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663

Query: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
           K+CG++ P  + S    + + F +D  V+K GF A ++ V
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSV 703



 Score =  138 bits (347), Expect = 3e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377

Query: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437

Query: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486

Query: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544

Query: 265 Y 265
           +
Sbjct: 545 F 545



 Score = 83.2 bits (204), Expect = 1e-15
 Identities = 49/122 (40%), Positives = 70/122 (57%), Gaps = 4/122 (3%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG L +K  G ITSPG+P++YP ++NC W + AP    +I L F+  FE E +D CKYD
Sbjct: 591 CGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPT-QYRISLQFD-FFETEGNDVCKYD 647

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
           F+E+R G +  + L GK CG+  P  I S  + + ++F SD      GF   +     G+
Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSVLEGA 707

Query: 147 ED 148
            D
Sbjct: 708 GD 709


>gi|4502421 bone morphogenetic protein 1 isoform 1 precursor [Homo
           sapiens]
          Length = 730

 Score =  150 bits (379), Expect = 5e-36
 Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 51/278 (18%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549

Query: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609

Query: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663

Query: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
           K+CG++ P  + S    + + F +D  V+K GF A ++
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701



 Score =  138 bits (347), Expect = 3e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377

Query: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437

Query: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486

Query: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544

Query: 265 Y 265
           +
Sbjct: 545 F 545


>gi|5453579 bone morphogenetic protein 1 isoform 3 precursor [Homo
           sapiens]
          Length = 986

 Score =  150 bits (379), Expect = 5e-36
 Identities = 95/278 (34%), Positives = 141/278 (50%), Gaps = 51/278 (18%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG +  KD G+I SP YP DY   + C W +   E    + L F   FEIE+HD C YD
Sbjct: 435 CGGDVK-KDYGHIQSPNYPDDYRPSKVCIWRIQVSE-GFHVGLTFQS-FEIERHDSCAYD 491

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK--- 143
           ++E+RDG SES+ L+G++CG   P  I S+ S L++KF SD +   AGF++ +  FK   
Sbjct: 492 YLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF--FKEVD 549

Query: 144 -----------------TGSEDCSKN-------------------FTSPNGTIESPGFPE 167
                             GS  CS +                    T  NG+I SPG+P+
Sbjct: 550 ECSRPNRGGCEQRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPK 609

Query: 168 KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG 227
           +YP N +C + ++A  +  I LQF  F+ E      G   CKYD++++  G+     L G
Sbjct: 610 EYPPNKNCIWQLVAPTQYRISLQFDFFETE------GNDVCKYDFVEVRSGLTADSKLHG 663

Query: 228 KYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYY 265
           K+CG++ P  + S    + + F +D  V+K GF A ++
Sbjct: 664 KFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFF 701



 Score =  145 bits (367), Expect = 1e-34
 Identities = 91/275 (33%), Positives = 139/275 (50%), Gaps = 47/275 (17%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
           CGG L +K  G ITSPG+P++YP ++NC W + AP    +I L F+  FE E +D CKYD
Sbjct: 591 CGGFL-TKLNGSITSPGWPKEYPPNKNCIWQLVAPT-QYRISLQFD-FFETEGNDVCKYD 647

Query: 87  FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY-----EI 141
           F+E+R G +  + L GK CG+  P  I S  + + ++F SD      GF   +     E 
Sbjct: 648 FVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNTVSKKGFKAHFFSDKDEC 707

Query: 142 FKTGS---EDCSKNF-----------------------------TSPNGTIESPGFPEKY 169
            K      +DC   F                             TS +GTI SP +P+KY
Sbjct: 708 SKDNGGCQQDCVNTFGSYECQCRSGFVLHDNKHDCKEAGCDHKVTSTSGTITSPNWPDKY 767

Query: 170 PHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKY 229
           P   +CT+ I + P   + L F+  D+E  P      +C YD L+++DG     P++G++
Sbjct: 768 PSKKECTWAISSTPGHRVKLTFMEMDIESQP------ECAYDHLEVFDGRDAKAPVLGRF 821

Query: 230 CGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
           CG+K P  + ++   + L F++D +V + GF A +
Sbjct: 822 CGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH 856



 Score =  138 bits (347), Expect = 3e-32
 Identities = 81/241 (33%), Positives = 124/241 (51%), Gaps = 16/241 (6%)

Query: 26  PPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY 85
           P CG  L     G  +SP YP  Y +H +C W + +  P +KI+LNF          C Y
Sbjct: 320 PACGETLQDS-TGNFSSPEYPNGYSAHMHCVWRI-SVTPGEKIILNFTSLDLYRSRLCWY 377

Query: 86  DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
           D++E+RDG    A L G+ CG+  P  I+S+ S L+++F S     G GF   YE    G
Sbjct: 378 DYVEVRDGFWRKAPLRGRFCGSKLPEPIVSTDSRLWVEFRSSSNWVGKGFFAVYEAICGG 437

Query: 146 SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE-HDPLQVG 204
             D  K++    G I+SP +P+ Y  +  C + I       + L F  F++E HD     
Sbjct: 438 --DVKKDY----GHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHD----- 486

Query: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
              C YD+L++ DG      LIG+YCG + P +++S++  L L F +D ++ K GF+  +
Sbjct: 487 --SCAYDYLEVRDGHSESSTLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF 544

Query: 265 Y 265
           +
Sbjct: 545 F 545



 Score =  129 bits (325), Expect = 9e-30
 Identities = 69/232 (29%), Positives = 119/232 (51%), Gaps = 17/232 (7%)

Query: 37  AGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSE 96
           +G ITSP +P  YPS + C W + +  P  ++ L F       + +C YD +E+ DG   
Sbjct: 755 SGTITSPNWPDKYPSKKECTWAI-SSTPGHRVKLTFMEMDIESQPECAYDHLEVFDGRDA 813

Query: 97  SADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSP 156
            A +LG+ CG+  P  ++++GS ++++F SD + Q  GF   +      + +C     + 
Sbjct: 814 KAPVLGRFCGSKKPEPVLATGSRMFLRFYSDNSVQRKGFQASH------ATECGGQVRAD 867

Query: 157 NGTIESPGFPE----KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDW 212
             T +     +     YP  +DC + I+A+    + L F  F++E       E DC YD+
Sbjct: 868 VKTKDLYSHAQFGDNNYPGGVDCEWVIVAEEGYGVELVFQTFEVEE------ETDCGYDY 921

Query: 213 LDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
           ++++DG     P +G+YCG+  P E+ S+   + + FH+D  + K GF  RY
Sbjct: 922 MELFDGYDSTAPRLGRYCGSGPPEEVYSAGDSVLVKFHSDDTITKKGFHLRY 973


>gi|126091152 cubilin [Homo sapiens]
          Length = 3623

 Score =  145 bits (367), Expect = 1e-34
 Identities = 85/246 (34%), Positives = 124/246 (50%), Gaps = 13/246 (5%)

Query: 21   RGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK 80
            R Q    CGG + +     ++SP +P +YP++QNC WI+ A  P   I L+F  HFE+E+
Sbjct: 1613 RAQFRQACGGHILTSSFDTVSSPRFPANYPNNQNCSWIIQAQPPLNHITLSFT-HFELER 1671

Query: 81   H-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
               C  DF+EI DG  E A L G++CG   P  I S  S L ++F SD +    GF   +
Sbjct: 1672 STTCARDFVEILDGGHEDAPLRGRYCGTDMPHPITSFSSALTLRFVSDSSISAGGF---H 1728

Query: 140  EIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHD 199
                     C   F    G   SPG+P+ YP N++C + I++ P   + L F+ F LE  
Sbjct: 1729 TTVTASVSACGGTFYMAEGIFNSPGYPDIYPPNVECVWNIVSSPGNRLQLSFISFQLEDS 1788

Query: 200  PLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTG-ILSLTFHTDMAVAKD 258
                   DC  D+++I +G    G L+G+YCG   P    S  G  L + F +D + +  
Sbjct: 1789 Q------DCSRDFVEIREG-NATGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGT 1841

Query: 259  GFSARY 264
            GF A +
Sbjct: 1842 GFQATF 1847



 Score =  137 bits (346), Expect = 3e-32
 Identities = 80/242 (33%), Positives = 123/242 (50%), Gaps = 18/242 (7%)

Query: 28   CGGRLNSKDA---GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE-KHDC 83
            CGG +   DA   GY+TSP +P +YP H +C WI+ AP P  +I L F   F+IE   +C
Sbjct: 2217 CGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAP-PETRIQLQFEDRFDIEVTPNC 2275

Query: 84   KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
              +++E+RDG    A +L K CG   P +  SSG ++Y++F SD +    GF  +Y I  
Sbjct: 2276 TSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDNSPTHVGFKAKYSI-- 2333

Query: 144  TGSEDCSKNFTSPNGTIESPGFPE-KYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQ 202
                 C       +G +ES G P   Y  NL C + +       + + F  F+L++    
Sbjct: 2334 ---AQCGGRVPGQSGVVESIGHPTLPYRDNLFCEWHLQGLSGHYLTISFEDFNLQN---- 2386

Query: 203  VGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSA 262
                 C+ D+++IWD     G ++G+YCG   P  + +S+    + F TD +V   GF  
Sbjct: 2387 --SSGCEKDFVEIWDNHTS-GNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRL 2443

Query: 263  RY 264
            R+
Sbjct: 2444 RF 2445



 Score =  136 bits (342), Expect = 1e-31
 Identities = 80/245 (32%), Positives = 126/245 (51%), Gaps = 19/245 (7%)

Query: 24  PDPPCGGRLNSKDAGY-ITSP--GYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK 80
           P   CG  L+  +  +   SP  GY  D     NC W++   E  + + + F   F +E 
Sbjct: 470 PQQVCGESLSGINGSFSYRSPDVGYVHDV----NCFWVIKT-EMGKVLRITFT-FFRLES 523

Query: 81  HD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRY 139
            D C ++F+++ DGDS SA  LG+ CG+  P  ++SS + LY    S++ R G GF++R+
Sbjct: 524 MDNCPHEFLQVYDGDSSSAFQLGRFCGSSLPHELLSSDNALYFHLYSEHLRNGRGFTVRW 583

Query: 140 EIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHD 199
           E   T   +C    T P G+I+SPG+P  YP   DC + ++  P + +   F    LEH 
Sbjct: 584 E---TQQPECGGILTGPYGSIKSPGYPGNYPPGRDCVWIVVTSPDLLVTFTFGTLSLEH- 639

Query: 200 PLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDG 259
                  DC  D+L+I DG  +  PL+GK+C T +   L+++     + FH+D  ++  G
Sbjct: 640 -----HDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPFARIHFHSDSQISDQG 694

Query: 260 FSARY 264
           F   Y
Sbjct: 695 FHITY 699



 Score =  134 bits (337), Expect = 4e-31
 Identities = 83/251 (33%), Positives = 129/251 (51%), Gaps = 25/251 (9%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY-- 85
            CGG L++ D G ITSP YP+ YPS+ NC W V   +    I ++F   F+I   D     
Sbjct: 2092 CGGYLHA-DRGIITSPKYPETYPSNLNCSWHVLV-QSGLTIAVHFEQPFQIPNGDSSCNQ 2149

Query: 86   -DFIEIRDGDSESADLLGK------HCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLR 138
             D++ +R+G    +  LG        CG+ A  T+ +S + ++++F SD++ +G GF ++
Sbjct: 2150 GDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNEGQGFKIK 2209

Query: 139  YEIFKTGSEDCSKNF----TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFL-I 193
            YE     S  C  N         G + SP  P  YP + DC + + A P+  I LQF   
Sbjct: 2210 YE---AKSLACGGNVYIHDADSAGYVTSPNHPHNYPPHADCIWILAAPPETRIQLQFEDR 2266

Query: 194  FDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDM 253
            FD+E  P      +C  ++L++ DG+    P++ K+CGT  PS   SS  ++ L F +D 
Sbjct: 2267 FDIEVTP------NCTSNYLELRDGVDSDAPILSKFCGTSLPSSQWSSGEVMYLRFRSDN 2320

Query: 254  AVAKDGFSARY 264
            +    GF A+Y
Sbjct: 2321 SPTHVGFKAKY 2331



 Score =  133 bits (335), Expect = 7e-31
 Identities = 81/234 (34%), Positives = 121/234 (51%), Gaps = 11/234 (4%)

Query: 30   GRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DCKYDFI 88
            G + ++  G I SPG+P  YP   NC W +   +PN  I L F   F +E H +C  D++
Sbjct: 933  GEILTESTGTIQSPGHPNVYPHGINCTWHILV-QPNHLIHLMFET-FHLEFHYNCTNDYL 990

Query: 89   EIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSED 148
            E+ D DSE++  LG++CG   PP++ SSG+ L + F +D      GF + YE     +  
Sbjct: 991  EVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINYEAISAATA- 1047

Query: 149  CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
            C +++T   GT  SP FP  YP+N +C + I  +    I + F  F LE        G+ 
Sbjct: 1048 CLQDYTDDLGTFTSPNFPNNYPNNWECIYRITVRTGQLIAVHFTNFSLEE-----AIGNY 1102

Query: 209  KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSA 262
              D+L+I DG     PL+G + G+  P  + S +  L L F +D    + GFSA
Sbjct: 1103 YTDFLEIRDGGYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSA 1156



 Score =  129 bits (323), Expect = 2e-29
 Identities = 78/239 (32%), Positives = 124/239 (51%), Gaps = 13/239 (5%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
            CGG +   D+G ITSP YP  Y S  +C  ++ AP+    I L F+  F+IE H  C +D
Sbjct: 2689 CGG-IQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQ-GHTITLTFSD-FDIEPHTTCAWD 2745

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
             + +R+G S  + ++G++CGN  P TI S  + L + F SD++ QG GF   Y  + T +
Sbjct: 2746 SVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGF---YATWNTQT 2802

Query: 147  EDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEG 206
              C   F S NGTI SP +P+ +P N  C++T +      + + F      +  +  G+G
Sbjct: 2803 LGCGGIFHSDNGTIRSPHWPQNFPENSRCSWTAITHKSKHLEISF----DNNFLIPSGDG 2858

Query: 207  DCKYDWLDIWDGIPHVG-PLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
             C+  ++ +W G   V   L+   CG   P  + + +   +  F +  A A+ GFSA +
Sbjct: 2859 QCQNSFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEAPAQ-GFSASF 2916



 Score =  128 bits (322), Expect = 2e-29
 Identities = 82/240 (34%), Positives = 117/240 (48%), Gaps = 20/240 (8%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI-EKHDCKYD 86
            CG  L  +  G I SP +P  YP  + C W ++ P+ +Q I+LNF   FEI     C+ D
Sbjct: 817  CGDELTGE--GVIRSPFFPNVYPGERTCRWTIHQPQ-SQVILLNFTV-FEIGSSAHCETD 872

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
            ++EI       +    K+CG   P  I S  + LY+ F    + +  GF  ++      +
Sbjct: 873  YVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAKFS-----A 927

Query: 147  ED--CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
            ED  C +  T   GTI+SPG P  YPH ++CT+ IL +P   I L F  F LE       
Sbjct: 928  EDLACGEILTESTGTIQSPGHPNVYPHGINCTWHILVQPNHLIHLMFETFHLEF------ 981

Query: 205  EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
              +C  D+L+++D        +G+YCG   P  L SS   L L F TD  +A +GF   Y
Sbjct: 982  HYNCTNDYLEVYDTDSETS--LGRYCGKSIPPSLTSSGNSLMLVFVTDSDLAYEGFLINY 1039



 Score =  126 bits (316), Expect = 1e-28
 Identities = 79/231 (34%), Positives = 118/231 (51%), Gaps = 13/231 (5%)

Query: 36   DAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKY--DFIEIRDG 93
            D G  TSP +P +YP++  C + +      Q I ++F  +F +E+    Y  DF+EIRDG
Sbjct: 1055 DLGTFTSPNFPNNYPNNWECIYRITV-RTGQLIAVHFT-NFSLEEAIGNYYTDFLEIRDG 1112

Query: 94   DSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNF 153
              E + LLG   G+  PPTIIS  + L++KF SD     +GFS  ++   TG   C  N 
Sbjct: 1113 GYEKSPLLGIFYGSNLPPTIISHSNKLWLKFKSDQIDTRSGFSAYWDGSSTG---CGGNL 1169

Query: 154  TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWL 213
            T+ +GT  SP +P  Y H+ +C + + +       L+F  F LEH P      +C  D+L
Sbjct: 1170 TTSSGTFISPNYPMPYYHSSECYWWLKSSHGSAFELEFKDFHLEHHP------NCTLDYL 1223

Query: 214  DIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
             ++DG      L+ + CG + P  +RSS   + +   TD      GF A Y
Sbjct: 1224 AVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEY 1274



 Score =  121 bits (304), Expect = 3e-27
 Identities = 84/243 (34%), Positives = 123/243 (50%), Gaps = 20/243 (8%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
            CGG     + G   SPGYP  YP +  C W + +  P  ++ L+F      +  DC  DF
Sbjct: 1738 CGGTFYMAE-GIFNSPGYPDIYPPNVECVWNIVS-SPGNRLQLSFISFQLEDSQDCSRDF 1795

Query: 88   IEIRDGDSESADLLGKHCGNIAPPTIISS-GSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
            +EIR+G++ +  L+G++CGN  P    S  G  L+++F SD +  G GF   +   K   
Sbjct: 1796 VEIREGNA-TGHLVGRYCGNSFPLNYSSIVGHTLWVRFISDGSGSGTGFQATF--MKIFG 1852

Query: 147  EDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEG 206
             D   N    +G + SP +PE YPHN +  +T+       +  + L  D+E         
Sbjct: 1853 ND---NIVGTHGKVASPFWPENYPHNSNYQWTVNVNASHVVHGRILEMDIEEIQ------ 1903

Query: 207  DCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFH--TDMAVAKDGFSARY 264
            +C YD L I+DG      LIG YCGT+T  E  SSTG  SLTFH  +D +++  GF   +
Sbjct: 1904 NCYYDKLRIYDGPSIHARLIGAYCGTQT--ESFSSTG-NSLTFHFYSDSSISGKGFLLEW 1960

Query: 265  YLV 267
            + V
Sbjct: 1961 FAV 1963



 Score =  118 bits (296), Expect = 2e-26
 Identities = 78/248 (31%), Positives = 124/248 (50%), Gaps = 26/248 (10%)

Query: 28   CGGRLNSKDAG-YITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DCKY 85
            CGG L + DA  ++ SPG+P  Y +  +C W++ AP+   ++ +      +IE H  C Y
Sbjct: 1978 CGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQAPDSTVELNIL---SLDIESHRTCAY 2034

Query: 86   DFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTG 145
            D + IRDGD+  A  L   CG   P  I S+G  ++I+FTSD +   AGF+  +      
Sbjct: 2035 DSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASFH----- 2089

Query: 146  SEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGE 205
             + C     +  G I SP +PE YP NL+C++ +L +  + I + F        P Q+  
Sbjct: 2090 -KSCGGYLHADRGIITSPKYPETYPSNLNCSWHVLVQSGLTIAVHF------EQPFQIPN 2142

Query: 206  GDC---KYDWLDIWDG----IPHVGPL--IGKYCGTKTPSELRSSTGILSLTFHTDMAVA 256
            GD    + D+L + +G     P +GP    G +CG+   S L +S   + + F +D +  
Sbjct: 2143 GDSSCNQGDYLVLRNGPDICSPPLGPPGGNGHFCGSHASSTLFTSDNQMFVQFISDHSNE 2202

Query: 257  KDGFSARY 264
              GF  +Y
Sbjct: 2203 GQGFKIKY 2210



 Score =  118 bits (296), Expect = 2e-26
 Identities = 73/243 (30%), Positives = 119/243 (48%), Gaps = 8/243 (3%)

Query: 28   CGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYD 86
            CGG  N   +G ITSP Y   DYP+  +C + +   + ++ I L F+    +    C +D
Sbjct: 3037 CGGVFNFS-SGIITSPAYSYADYPNDMHCLYTITVSD-DKVIELKFSDFDVVPSTSCSHD 3094

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
            ++ I DG + S  LLGK CG+  PP + SS + + + F +D  +   G+ + +       
Sbjct: 3095 YLAIYDGANTSDPLLGKFCGSKRPPNVKSSNNSMLLVFKTDSFQTAKGWKMSFRQTLGPQ 3154

Query: 147  EDCSKNFTSPNGTIESPGFPEK--YPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
            + C    T  N T  SP       Y  NL+C + I+A     I L F  F LE    +  
Sbjct: 3155 QGCGGYLTGSNNTFASPDSDSNGMYDKNLNCVWIIIAPVNKVIHLTFNTFALEAASTR-- 3212

Query: 205  EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
               C YD++ ++DG      L G +CG+  P+   SS   L++ F +D+ + ++GF+A Y
Sbjct: 3213 -QRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNATY 3271

Query: 265  YLV 267
             ++
Sbjct: 3272 TIM 3274



 Score =  117 bits (294), Expect = 4e-26
 Identities = 67/227 (29%), Positives = 113/227 (49%), Gaps = 11/227 (4%)

Query: 35   KDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGD 94
            K  G + SPG+P +Y + ++C   + AP+ N  I L F+        +C+ DF+E+R+G 
Sbjct: 3401 KAFGNLRSPGWPDNYDNDKDCTVTLTAPQ-NHTISLFFHSLGIENSVECRNDFLEVRNGS 3459

Query: 95   SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFT 154
            + ++ LLGK+CG + P  + S  + LY++F SD      G+ +   I+ +    C     
Sbjct: 3460 NSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGYEI---IWTSSPSGCGGTLY 3516

Query: 155  SPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLD 214
               G+  SPG+P  YP+N  C + ++A     + + F    ++ DP     GDC  ++L 
Sbjct: 3517 GDRGSFTSPGYPGTYPNNTYCEWVLVAPAGRLVTINFYFISID-DP-----GDCVQNYLT 3570

Query: 215  IWDGIPHVGPLIGKYCGTKTP-SELRSSTGILSLTFHTDMAVAKDGF 260
            ++DG     P  G YCG  T  +   +S+  + + FH D A     F
Sbjct: 3571 LYDGPNASSPSSGPYCGGDTSIAPFVASSNQVFIKFHADYARRPSAF 3617



 Score =  112 bits (279), Expect = 2e-24
 Identities = 81/265 (30%), Positives = 117/265 (44%), Gaps = 26/265 (9%)

Query: 12  ALYF---SRHQVRGQ--------PDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVY 60
           ALYF   S H   G+          P CGG L     G I SPGYP +YP  ++C WIV 
Sbjct: 563 ALYFHLYSEHLRNGRGFTVRWETQQPECGGILTGP-YGSIKSPGYPGNYPPGRDCVWIV- 620

Query: 61  APEPNQKIVLNFNPHFEIEKH-DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSM 119
              P+  +   F     +E H DC  D++EIRDG      LLGK C   + P + ++G  
Sbjct: 621 VTSPDLLVTFTFGT-LSLEHHDDCNKDYLEIRDGPLYQDPLLGKFCTTFSVPPLQTTGPF 679

Query: 120 LYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTI 179
             I F SD      GF + Y +       C  N+T P G +  P     + H   C + +
Sbjct: 680 ARIHFHSDSQISDQGFHITY-LTSPSDLRCGGNYTDPEGELFLPELSGPFTHTRQCVYMM 738

Query: 180 LAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELR 239
                 +I + F   +L+       + D   +++++ DG      L+GK CG  T S ++
Sbjct: 739 KQPQGEQIQINFTHVELQ------CQSDSSQNYIEVRDG----ETLLGKVCGNGTISHIK 788

Query: 240 SSTGILSLTFHTDMAVAKDGFSARY 264
           S T  + + F  D +V K  F A Y
Sbjct: 789 SITNSVWIRFKIDASVEKASFRAVY 813



 Score =  111 bits (278), Expect = 3e-24
 Identities = 75/255 (29%), Positives = 122/255 (47%), Gaps = 15/255 (5%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD--CKY 85
            CGG  +S D G I SP +PQ++P +  C W     + ++ + ++F+ +F I   D  C+ 
Sbjct: 2805 CGGIFHS-DNGTIRSPHWPQNFPENSRCSWTAITHK-SKHLEISFDNNFLIPSGDGQCQN 2862

Query: 86   DFIEIRDGDSE-SADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
             F+++  G  E    LL   CGN+AP  +I+  +     F S  A    GFS  +     
Sbjct: 2863 SFVKVWAGTEEVDKALLATGCGNVAPGPVITPSNTFTAVFQSQEA-PAQGFSASFV---- 2917

Query: 145  GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
                C  NFT P+G I SP +P++Y +N++CT+ I A P   ++L F+ F LE       
Sbjct: 2918 --SRCGSNFTGPSGYIISPNYPKQYDNNMNCTYVIEANPLSVVLLTFVSFHLE--ARSAV 2973

Query: 205  EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
             G C  D + I  G   +       CG + P+ L +  G + L F+++  +   GF   Y
Sbjct: 2974 TGSCVNDGVHIIRGYSVMSTPFATVCGDEMPAPL-TIAGPVLLNFYSNEQITDFGFKFSY 3032

Query: 265  YLVHQEPLENFQCNV 279
             ++    + NF   +
Sbjct: 3033 RIISCGGVFNFSSGI 3047



 Score =  111 bits (277), Expect = 3e-24
 Identities = 76/244 (31%), Positives = 116/244 (47%), Gaps = 25/244 (10%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH-DCKYD 86
            CGG L +    +I SP YP  Y     C W + +        L F   F +E H +C  D
Sbjct: 1165 CGGNLTTSSGTFI-SPNYPMPYYHSSECYWWLKSSH-GSAFELEFKD-FHLEHHPNCTLD 1221

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
            ++ + DG S ++ LL + CG+  PP I SSG  ++IK  +D  +QG GF   Y       
Sbjct: 1222 YLAVYDGPSSNSHLLTQLCGDEKPPLIRSSGDSMFIKLRTDEGQQGRGFKAEYR------ 1275

Query: 147  EDCSKNFTSPN---GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQV 203
            + C +N    N   G +ES G+P  Y  N  C +TI A     +   FL FDLEH     
Sbjct: 1276 QTC-ENVVIVNQTYGILESIGYPNPYSENQHCNWTIRATTGNTVNYTFLAFDLEH----- 1329

Query: 204  GEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTD-MAVAKDGFSA 262
               +C  D+L+++DG       +G+YCG   P    +++  L +   TD +   + GF  
Sbjct: 1330 -HINCSTDYLELYDGPRQ----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQM 1384

Query: 263  RYYL 266
            ++++
Sbjct: 1385 QWFV 1388



 Score =  109 bits (272), Expect = 1e-23
 Identities = 71/244 (29%), Positives = 115/244 (47%), Gaps = 16/244 (6%)

Query: 25   DPPCGGRLNSKDAGYITSPGYP--QDYPSHQNCEWIVYAP-EPNQKIVLNFNPHFEIEKH 81
            D  CGG L +   G  TSPGY   ++Y  + NCEW +  P + N  I ++F   +     
Sbjct: 2567 DAVCGGSLPNTPEGNFTSPGYDGVRNYSRNLNCEWTLSNPNQGNSSISIHFEDFYLESHQ 2626

Query: 82   DCKYDFIEIRDGDSESADLLGKHCGNIAPPT-IISSGSMLYIKFTSDYARQGAGFSLRYE 140
            DC++D +E R GD++   L+ + CG   P   ++   S ++I F ++   +  GF  +Y 
Sbjct: 2627 DCQFDVLEFRVGDADGP-LMWRLCGPSKPTLPLVIPYSQVWIHFVTNERVEHIGFHAKYS 2685

Query: 141  IFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDP 200
                   DC       +G I SP +P  Y     C+  + A     I L F  FD+E   
Sbjct: 2686 F-----TDCGGIQIGDSGVITSPNYPNAYDSLTHCSSLLEAPQGHTITLTFSDFDIE--- 2737

Query: 201  LQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGF 260
                   C +D + + +G     P+IG+YCG   P  ++S +  L +TF++D ++   GF
Sbjct: 2738 ---PHTTCAWDSVTVRNGGSPESPIIGQYCGNSNPRTIQSGSNQLVVTFNSDHSLQGGGF 2794

Query: 261  SARY 264
             A +
Sbjct: 2795 YATW 2798



 Score =  108 bits (270), Expect = 2e-23
 Identities = 67/236 (28%), Positives = 117/236 (49%), Gaps = 24/236 (10%)

Query: 38   GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFN-PHFEIEKH-DCKYDFIEIRDGDS 95
            G + S GYP  Y  +Q+C W + A   N    +N+    F++E H +C  D++E+ DG  
Sbjct: 1289 GILESIGYPNPYSENQHCNWTIRATTGN---TVNYTFLAFDLEHHINCSTDYLELYDGPR 1345

Query: 96   ESADLLGKHCG-NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFT 154
            +    +G++CG ++ PP   +S  +  +  T    R+  GF +++ ++  G E      +
Sbjct: 1346 Q----MGRYCGVDLPPPGSTTSSKLQVLLLTDGVGRREKGFQMQWFVYGCGGE-----LS 1396

Query: 155  SPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLD 214
               G+  SPGFP +YP N +C + I   P   I L    FD+E+         C +D L+
Sbjct: 1397 GATGSFSSPGFPNRYPPNKECIWYIRTDPGSSIQLTIHDFDVEY------HSRCNFDVLE 1450

Query: 215  IWDGIPHVGPLIGKYCGTKTPS---ELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
            I+ G     P I + C  ++P    ++ S+   L++ F TD+++   GF+A +  V
Sbjct: 1451 IYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAV 1506



 Score =  102 bits (253), Expect = 2e-21
 Identities = 65/239 (27%), Positives = 112/239 (46%), Gaps = 16/239 (6%)

Query: 25   DPPCGGRLNSK-DAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDC 83
            D PCGG  N+      I+SP           C W++ +P P+Q++ +      ++   DC
Sbjct: 3275 DMPCGGTYNATWTPQNISSPNSSDPDVPFSICTWVIDSP-PHQQVKITVWA-LQLTSQDC 3332

Query: 84   KYDFIEIRDGDSESADLLGKHCGNIAP--PTIISSGSMLYIKFTSDYARQGAGFSLRYEI 141
              ++++++D      +   + CG  A   P   SS S   + F S    + +  S  Y+I
Sbjct: 3333 TQNYLQLQDSPQGHGNSRFQFCGRNASAVPVFYSSMSTAMVIFKSGVVNRNSRMSFTYQI 3392

Query: 142  FKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPL 201
                  DC++++    G + SPG+P+ Y ++ DCT T+ A     I L F    +E+   
Sbjct: 3393 -----ADCNRDYHKAFGNLRSPGWPDNYDNDKDCTVTLTAPQNHTISLFFHSLGIENSV- 3446

Query: 202  QVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGF 260
                 +C+ D+L++ +G     PL+GKYCGT  P+ + S    L L F +D   +  G+
Sbjct: 3447 -----ECRNDFLEVRNGSNSNSPLLGKYCGTLLPNPVFSQNNELYLRFKSDSVTSDRGY 3500



 Score =  100 bits (249), Expect = 6e-21
 Identities = 68/239 (28%), Positives = 114/239 (47%), Gaps = 14/239 (5%)

Query: 28   CGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYD 86
            CGGR+  + +G + S G+P   Y  +  CEW +     +  + ++F          C+ D
Sbjct: 2336 CGGRVPGQ-SGVVESIGHPTLPYRDNLFCEWHLQGLSGHY-LTISFEDFNLQNSSGCEKD 2393

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGS 146
            F+EI D  + S ++LG++CGN  P +I +S +   ++F +D +   +GF LR+E   +  
Sbjct: 2394 FVEIWDNHT-SGNILGRYCGNTIPDSIDTSSNTAVVRFVTDGSVTASGFRLRFE---SSM 2449

Query: 147  EDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEG 206
            E+C  +     GT  SP +P   PH   C + I A     I L F    L   P      
Sbjct: 2450 EECGGDLQGSIGTFTSPNYPNPNPHGRICEWRITAPEGRRITLMFNNLRLATHP------ 2503

Query: 207  DCKYDWLDIWDGIPHVGPLIGKYCGT-KTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
             C  + + +++GI    P + K C +    +E++SS   + + F TD +    GF+A Y
Sbjct: 2504 SCNNEHVIVFNGIRSNSPQLEKLCSSVNVSNEIKSSGNTMKVIFFTDGSRPYGGFTASY 2562



 Score = 99.0 bits (245), Expect = 2e-20
 Identities = 68/242 (28%), Positives = 113/242 (46%), Gaps = 21/242 (8%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHD-CKYD 86
            CGG L+    G  +SPG+P  YP ++ C W +   +P   I L  +  F++E H  C +D
Sbjct: 1391 CGGELSGA-TGSFSSPGFPNRYPPNKECIWYIRT-DPGSSIQLTIHD-FDVEYHSRCNFD 1447

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPT---IISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
             +EI  G    +  + + C   +P     + S+G+ L I+F +D +  G GF+  ++   
Sbjct: 1448 VLEIYGGPDFHSPRIAQLCTQRSPENPMQVSSTGNELAIRFKTDLSINGRGFNASWQAVT 1507

Query: 144  TGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQV 203
             G   C   F +P+G I SP +P  Y  N DC++ I       ++L F  FDLE      
Sbjct: 1508 GG---CGGIFQAPSGEIHSPNYPSPYRSNTDCSWVIRVDRNHRVLLNFTDFDLE------ 1558

Query: 204  GEGDCKYDWLDIWDGIPHVGPLIGKYCG-TKTPSELRSSTGILSLTFHTDMAVAKDGFSA 262
             +  C    +  +DG+      + + CG  +  + + SS   L L F +  +    GF A
Sbjct: 1559 PQDSC----IMAYDGLSSTMSRLARTCGREQLANPIVSSGNSLFLRFQSGPSRQNRGFRA 1614

Query: 263  RY 264
            ++
Sbjct: 1615 QF 1616



 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 70/241 (29%), Positives = 113/241 (46%), Gaps = 25/241 (10%)

Query: 38   GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEK-HDCKYDFIEIRDGDSE 96
            G + SP +P++YP + N +W V     +  +V       +IE+  +C YD + I DG S 
Sbjct: 1861 GKVASPFWPENYPHNSNYQWTVNVNASH--VVHGRILEMDIEEIQNCYYDKLRIYDGPSI 1918

Query: 97   SADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSEDCSKNFTSP 156
             A L+G +CG     +  S+G+ L   F SD +  G GF L +  F   + D      +P
Sbjct: 1919 HARLIGAYCGT-QTESFSSTGNSLTFHFYSDSSISGKGFLLEW--FAVDAPDGVLPTIAP 1975

Query: 157  NGT------------IESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
                           + SPG+P+ Y + +DCT+ I A P   + L  L  D+E       
Sbjct: 1976 GACGGFLRTGDAPVFLFSPGWPDSYSNRVDCTWLIQA-PDSTVELNILSLDIE------S 2028

Query: 205  EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
               C YD L I DG  ++   +   CG + P  +RS+   + + F +D +V + GF+A +
Sbjct: 2029 HRTCAYDSLVIRDGDNNLAQQLAVLCGREIPGPIRSTGEYMFIRFTSDSSVTRAGFNASF 2088

Query: 265  Y 265
            +
Sbjct: 2089 H 2089



 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 70/241 (29%), Positives = 109/241 (45%), Gaps = 21/241 (8%)

Query: 25  DPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE-KHDC 83
           D  CGG     + G +  P     +   + C +++  P+  Q I +NF  H E++ + D 
Sbjct: 705 DLRCGGNYTDPE-GELFLPELSGPFTHTRQCVYMMKQPQGEQ-IQINFT-HVELQCQSDS 761

Query: 84  KYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
             ++IE+RDG++    LLGK CGN     I S  + ++I+F  D + + A F   Y++  
Sbjct: 762 SQNYIEVRDGET----LLGKVCGNGTISHIKSITNSVWIRFKIDASVEKASFRAVYQV-- 815

Query: 144 TGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQV 203
                C    T   G I SP FP  YP    C +TI       I+L F +F++       
Sbjct: 816 ----ACGDELTG-EGVIRSPFFPNVYPGERTCRWTIHQPQSQVILLNFTVFEIG------ 864

Query: 204 GEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSAR 263
               C+ D+++I        P   KYCGT  PS + S    L +TF    +    GF A+
Sbjct: 865 SSAHCETDYVEIGSSSILGSPENKKYCGTDIPSFITSVYNFLYVTFVKSSSTENHGFMAK 924

Query: 264 Y 264
           +
Sbjct: 925 F 925



 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 72/248 (29%), Positives = 113/248 (45%), Gaps = 34/248 (13%)

Query: 24   PDPPCGGRLNSKDAGYITSPGYPQD--YPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE-- 79
            P   CGG L   +  +  SP    +  Y  + NC WI+ AP  N+ I L FN  F +E  
Sbjct: 3153 PQQGCGGYLTGSNNTF-ASPDSDSNGMYDKNLNCVWIIIAPV-NKVIHLTFNT-FALEAA 3209

Query: 80   --KHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSL 137
              +  C YD++++ DGDSE+A+L G  CG+  P   ISSG+ L ++F SD   +  GF+ 
Sbjct: 3210 STRQRCLYDYVKLYDGDSENANLAGTFCGSTVPAPFISSGNFLTVQFISDLTLEREGFNA 3269

Query: 138  RYEIFKT---GSEDCS---KNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQF 191
             Y I      G+ + +   +N +SPN +   P  P        CT+ I + P  ++ +  
Sbjct: 3270 TYTIMDMPCGGTYNATWTPQNISSPNSS--DPDVPFSI-----CTWVIDSPPHQQVKITV 3322

Query: 192  LIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHT 251
                     LQ+   DC  ++L + D     G    ++CG        S+  +   +  T
Sbjct: 3323 W-------ALQLTSQDCTQNYLQLQDSPQGHGNSRFQFCGRNA-----SAVPVFYSSMST 3370

Query: 252  DMAVAKDG 259
             M + K G
Sbjct: 3371 AMVIFKSG 3378



 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 42/116 (36%), Positives = 68/116 (58%), Gaps = 7/116 (6%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
            CGG L   D G  TSPGYP  YP++  CEW++ AP   + + +NF      +  DC  ++
Sbjct: 3511 CGGTLYG-DRGSFTSPGYPGTYPNNTYCEWVLVAPA-GRLVTINFYFISIDDPGDCVQNY 3568

Query: 88   IEIRDGDSESADLLGKHCG---NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
            + + DG + S+   G +CG   +IAP   ++S + ++IKF +DYAR+ + F L ++
Sbjct: 3569 LTLYDGPNASSPSSGPYCGGDTSIAP--FVASSNQVFIKFHADYARRPSAFRLTWD 3622


>gi|157653329 procollagen C-endopeptidase enhancer [Homo sapiens]
          Length = 449

 Score =  140 bits (354), Expect = 4e-33
 Identities = 86/268 (32%), Positives = 133/268 (49%), Gaps = 17/268 (6%)

Query: 5   PLTWVFLALYFSRHQVRGQPDPP--CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAP 62
           PL      L F++ Q      P   CGG +   ++GY+ S G+P  YP ++ C W +  P
Sbjct: 12  PLLTACALLPFAQGQTPNYTRPVFLCGGDVKG-ESGYVASEGFPNLYPPNKECIWTITVP 70

Query: 63  EPNQKIVLNFNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLY 121
           E  Q + L+F   F++E H  C+YD +E+  G   S   LG+ CG   P  +++ G+ + 
Sbjct: 71  E-GQTVSLSFRV-FDLELHPACRYDALEVFAGSGTSGQRLGRFCGTFRPAPLVAPGNQVT 128

Query: 122 IKFTSDYARQGAGFSLRYEIFKTGSED---CSKNFTSPNGTIESPGFPEK-YPHNLDCTF 177
           ++ T+D    G GF L Y    T   +   C        GT+ +P +PE  YP  + C++
Sbjct: 129 LRMTTDEGTGGRGFLLWYSGRATSGTEHQFCGGRLEKAQGTLTTPNWPESDYPPGISCSW 188

Query: 178 TILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG-IPHVGPLIGKYCGTKTPS 236
            I+A P   I L F  FDLE D        C+YD + +++G +      +GK+CG   P 
Sbjct: 189 HIIAPPDQVIALTFEKFDLEPDTY------CRYDSVSVFNGAVSDDSRRLGKFCGDAVPG 242

Query: 237 ELRSSTGILSLTFHTDMAVAKDGFSARY 264
            + S    L + F +D++V  DGFSA Y
Sbjct: 243 SISSEGNELLVQFVSDLSVTADGFSASY 270



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 54/159 (33%), Positives = 80/159 (50%), Gaps = 6/159 (3%)

Query: 13  LYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQ-DYPSHQNCEWIVYAPEPNQKIVLN 71
           L++S     G     CGGRL  K  G +T+P +P+ DYP   +C W + AP P+Q I L 
Sbjct: 144 LWYSGRATSGTEHQFCGGRLE-KAQGTLTTPNWPESDYPPGISCSWHIIAP-PDQVIALT 201

Query: 72  FNPHFEIEKHD-CKYDFIEIRDGD-SESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA 129
           F   F++E    C+YD + + +G  S+ +  LGK CG+  P +I S G+ L ++F SD +
Sbjct: 202 FEK-FDLEPDTYCRYDSVSVFNGAVSDDSRRLGKFCGDAVPGSISSEGNELLVQFVSDLS 260

Query: 130 RQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEK 168
               GFS  Y+    G+    +      GT      P K
Sbjct: 261 VTADGFSASYKTLPRGTAKEGQGPGPKRGTEPKVKLPPK 299


>gi|72384339 CUB domain containing protein 2 [Homo sapiens]
          Length = 449

 Score =  137 bits (344), Expect = 6e-32
 Identities = 82/240 (34%), Positives = 123/240 (51%), Gaps = 17/240 (7%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEP-NQKIVLNFNPHFEIE-KHDCKY 85
           CGG L    +G +TSP YP +YP+   C W++ A  P + K+V      F++E   +C Y
Sbjct: 145 CGGVLTGL-SGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVF---VDFQVEGNEECTY 200

Query: 86  DFIEIRDGDSESADLLGKH-CGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKT 144
           D++ +  G   +    G H CG+  PPT++S G  L + F SD+   G GF   Y     
Sbjct: 201 DYVAVLGGPGPTR---GHHYCGSTRPPTLVSLGHELQVVFKSDFNIGGRGFKAYYF---- 253

Query: 145 GSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
            S +C + + +  G   SP +P  YP+N+ C +TI   P  ++ + FL  DLE +P  + 
Sbjct: 254 -SGECQEVYMAMRGNFSSPQYPSSYPNNIRCHWTIRLPPGYQVKVFFLDLDLE-EPNSLT 311

Query: 205 EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
           +  C +D L  +DG     PL+G +CG   P  + SS   L L  HTD +  + GFS  Y
Sbjct: 312 K-TCDFDHLAAFDGASEEAPLLGNWCGHHLPPPVTSSHNQLLLLLHTDRSTTRRGFSVAY 370



 Score =  126 bits (317), Expect = 8e-29
 Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 20/250 (8%)

Query: 19  QVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEI 78
           Q +      CGG L S  +G  +SP +P+ YP +  C W++   E    ++L F+  F++
Sbjct: 21  QAQAMEGVKCGGVL-SAPSGNFSSPNFPRLYPYNTECSWLIVVAE-GSSVLLTFHA-FDL 77

Query: 79  EKHD-CKYDFIEIRDGDS-ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFS 136
           E HD C +DF+EI +G S +  +LLG+ CG + PP   SS  ++ + F SD      GFS
Sbjct: 78  EYHDTCSFDFLEIYNGASPDKGNLLGRFCGKVPPPPFTSSWHVMSVIFHSDKHVASHGFS 137

Query: 137 LRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDL 196
             Y+      + C    T  +G + SP +P  YP++++C + I A     + L F+ F +
Sbjct: 138 AGYQ-----KDVCGGVLTGLSGVLTSPEYPNNYPNSMECHWVIRAAGPAHVKLVFVDFQV 192

Query: 197 EHDPLQVGEGDCKYDWLDIWDGIPHVGPLIG-KYCGTKTPSELRSSTGILSLTFHTDMAV 255
           E      G  +C YD++ +  G    GP  G  YCG+  P  L S    L + F +D  +
Sbjct: 193 E------GNEECTYDYVAVLGG---PGPTRGHHYCGSTRPPTLVSLGHELQVVFKSDFNI 243

Query: 256 AKDGFSARYY 265
              GF A Y+
Sbjct: 244 GGRGFKAYYF 253


>gi|7019483 procollagen C-endopeptidase enhancer 2 [Homo sapiens]
          Length = 415

 Score =  131 bits (329), Expect = 3e-30
 Identities = 80/259 (30%), Positives = 136/259 (52%), Gaps = 16/259 (6%)

Query: 12  ALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
           A   SR Q   +P   CGG L   ++G+I S G+P  YP +  C W +  PE  + +VLN
Sbjct: 17  ATQLSRQQSPERPVFTCGGILTG-ESGFIGSEGFPGVYPPNSKCTWKITVPE-GKVVVLN 74

Query: 72  FNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYAR 130
           F    ++E  + C+YDF+++ +G + +   +G+ CG   P  ++SSG+ + ++  SD   
Sbjct: 75  FR-FIDLESDNLCRYDFVDVYNGHA-NGQRIGRFCGTFRPGALVSSGNKMMVQMISDANT 132

Query: 131 QGAGFSLRY---EIFKTGSEDCSKNFTSPNGTIESPGFPEK-YPHNLDCTFTILAKPKME 186
            G GF   +   E  + G + C      P+G+ ++P +P++ YP  + C + I+A     
Sbjct: 133 AGNGFMAMFSAAEPNERGDQYCGGLLDRPSGSFKTPNWPDRDYPAGVTCVWHIVAPKNQL 192

Query: 187 IILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIP-HVGPLIGKYCGTKTPSELRSSTGIL 245
           I L+F  FD+E D        C+YD++ +++G   +    IGKYCG   P+ + S    L
Sbjct: 193 IELKFEKFDVERDNY------CRYDYVAVFNGGEVNDARRIGKYCGDSPPAPIVSERNEL 246

Query: 246 SLTFHTDMAVAKDGFSARY 264
            + F +D+++  DGF   Y
Sbjct: 247 LIQFLSDLSLTADGFIGHY 265



 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 45/138 (32%), Positives = 64/138 (46%), Gaps = 7/138 (5%)

Query: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
           C    T  +G I S GFP  YP N  CT+ I       ++L F   DLE D L      C
Sbjct: 33  CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNL------C 86

Query: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
           +YD++D+++G  + G  IG++CGT  P  L SS   + +   +D   A +GF A +    
Sbjct: 87  RYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSSGNKMMVQMISDANTAGNGFMAMFSAAE 145

Query: 269 QEPLENFQCNVPLGMESG 286
                +  C   L   SG
Sbjct: 146 PNERGDQYCGGLLDRPSG 163


>gi|10518506 coagulation factor VIII isoform b precursor [Homo
           sapiens]
          Length = 216

 Score =  128 bits (321), Expect = 3e-29
 Identities = 67/159 (42%), Positives = 97/159 (61%), Gaps = 6/159 (3%)

Query: 277 CNVPLGMESGRIANEQISASSTYSD--GRWTPQQSRLH--GDDNGWTPNLDSNKEYLQVD 332
           C++PLGMES  I++ QI+ASS +++    W+P ++RLH  G  N W P +++ KE+LQVD
Sbjct: 58  CSMPLGMESKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWRPQVNNPKEWLQVD 117

Query: 333 LRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDWMVYRHGKNHKVFQANNDATE 392
            +    +T + TQG  S  T    YVK + +  S +G  W ++      KVFQ N D+  
Sbjct: 118 FQKTMKVTGVTTQGVKSLLTS--MYVKEFLISSSQDGHQWTLFFQNGKVKVFQGNQDSFT 175

Query: 393 VVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTD 431
            V+N L  PLLTR++RI PQ+W   IALR+E+ GC   D
Sbjct: 176 PVVNSLDPPLLTRYLRIHPQSWVHQIALRMEVLGCEAQD 214



 Score =  114 bits (285), Expect = 4e-25
 Identities = 78/221 (35%), Positives = 119/221 (53%), Gaps = 20/221 (9%)

Query: 382 KVFQANNDATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGML 441
           KVF  N D++ +  N  + P++ R++R+ P  +     LR+EL GC +    CS  LGM 
Sbjct: 8   KVFFGNVDSSGIKHNIFNPPIIARYIRLHPTHYSIRSTLRMELMGCDLNS--CSMPLGME 65

Query: 442 SGLIADSQISASS---TQEYLWSPSAARL-VSSRSGWFPRIPQAQPGEEWLQVDLGTPKT 497
           S  I+D+QI+ASS        WSPS ARL +  RS  +   PQ    +EWLQVD      
Sbjct: 66  SKAISDAQITASSYFTNMFATWSPSKARLHLQGRSNAWR--PQVNNPKEWLQVDFQKTMK 123

Query: 498 VKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWE-YIQDPRTQQPKLFEGNMHYD 556
           V GV  QG      + ++    +V++F +S S +G  W  + Q+ +    K+F+GN    
Sbjct: 124 VTGVTTQG------VKSLLTSMYVKEFLISSSQDGHQWTLFFQNGKV---KVFQGNQDSF 174

Query: 557 TPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCDWTD 596
           TP +   D P+  +Y+R++P+ W    I +R+EVLGC+  D
Sbjct: 175 TPVVNSLDPPLLTRYLRIHPQSWVHQ-IALRMEVLGCEAQD 214


>gi|54792129 discoidin, CUB and LCCL domain containing 2 [Homo
           sapiens]
          Length = 775

 Score =  128 bits (321), Expect = 3e-29
 Identities = 112/440 (25%), Positives = 190/440 (43%), Gaps = 62/440 (14%)

Query: 9   VFLALYFSRHQVRGQPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKI 68
           + L L         Q    CG  +   ++G +TS  YPQ YP+   CEW +   +  +++
Sbjct: 53  LLLVLLLLLEDAGAQQGDGCGHTVLGPESGTLTSINYPQTYPNSTVCEWEIRV-KMGERV 111

Query: 69  VLNFNPHFEIEKHD-CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSD 127
            + F   F+IE  D C ++++ I +G   S   +GK+CG             L ++    
Sbjct: 112 RIKFGD-FDIEDSDSCHFNYLRIYNGIGVSRTEIGKYCG-------------LGLQMNHS 157

Query: 128 YARQGAGFSLRYEIFKTGSEDCSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEI 187
              +G   +L   +F +G     + F +                    +++++ K  +  
Sbjct: 158 IESKGNEITL---LFMSGIHVSGRGFLA--------------------SYSVIDKQDLIT 194

Query: 188 ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSST--GIL 245
            L      LE +  +     C   + +I   IPH        C     + + S+T  G +
Sbjct: 195 CLDTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSPLCMAGVHAGVVSNTLGGQI 254

Query: 246 SLTF-----HTDMAVAKDGFSARYYLVHQEPLENFQ---CNVPLGMESGRIANEQISASS 297
           S+       + + ++A +  S   +L     L  F+   C   LGMESG IA+ QI+ASS
Sbjct: 255 SVVISKGIPYYESSLANNVTSVVGHL--STSLFTFKTSGCYGTLGMESGVIADPQITASS 312

Query: 298 -------TYSDGRWTPQQSRLHGDDNGWTPNLDSNKEYLQVDLRFLTMLTAIATQGAISR 350
                  T  +  W P+++RL      W        ++LQ+DL     +T I T G  S 
Sbjct: 313 VLEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQIDLNKEKKITGIITTG--ST 370

Query: 351 ETQNGYYVKSYKLEVSTNGEDWMVYRHG--KNHKVFQANNDATEVVLNKLHAPLLTRFVR 408
             ++ YYV +Y++  S +G+ W VYR    +  K+FQ N D  + V N    P++ RF+R
Sbjct: 371 MVEHNYYVSAYRILYSDDGQKWTVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIR 430

Query: 409 IRPQTWHSGIALRLELFGCR 428
           + P  W   IA+++EL GC+
Sbjct: 431 VNPTQWQQKIAMKMELLGCQ 450



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 62/171 (36%), Positives = 89/171 (52%), Gaps = 21/171 (12%)

Query: 434 CSNMLGMLSGLIADSQISASST--------QEYLWSPSAARLVSSRSGWFPRIPQAQPGE 485
           C   LGM SG+IAD QI+ASS         QE  W P  ARL      W      A    
Sbjct: 292 CYGTLGMESGVIADPQITASSVLEWTDHTGQENSWKPKKARLKKPGPPW---AAFATDEY 348

Query: 486 EWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQ 545
           +WLQ+DL   K + G+I  G+      T VE   +V  +++ YS +G+ W   ++P  +Q
Sbjct: 349 QWLQIDLNKEKKITGIITTGS------TMVEHNYYVSAYRILYSDDGQKWTVYREPGVEQ 402

Query: 546 PKLFEGNMHYDTPDIRR--FDPIPAQYVRVYPERWSPAGIGMRLEVLGCDW 594
            K+F+GN  Y   D+R     PI A+++RV P +W    I M++E+LGC +
Sbjct: 403 DKIFQGNKDYH-QDVRNNFLPPIIARFIRVNPTQWQQK-IAMKMELLGCQF 451


>gi|24041026 neuropilin- and tolloid-like protein 2 precursor [Homo
           sapiens]
          Length = 525

 Score =  125 bits (315), Expect = 1e-28
 Identities = 73/237 (30%), Positives = 121/237 (51%), Gaps = 24/237 (10%)

Query: 24  PDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIE-KHD 82
           P   CG  + + + G+  SP YP  YP ++ C +I+ A  P Q+I L F+ H+ IE   +
Sbjct: 41  PATQCGIWVRTSNGGHFASPNYPDSYPPNKECIYILEAA-PRQRIELTFDEHYYIEPSFE 99

Query: 83  CKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIF 142
           C++D +E+RDG    + L+ ++CG  +PP I S+G  ++IKF+SD   +G GF  +Y   
Sbjct: 100 CRFDHLEVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFI 159

Query: 143 KTGS-----------EDCSKNFTSPNGTIESPGFPE----KYPHNLDCTFTILAKPKMEI 187
                           DC    +  +G + S    +    K    +DC +TI A PK +I
Sbjct: 160 PDPDFTYLGGILNPIPDCQFELSGADGIVRSSQVEQEEKTKPGQAVDCIWTIKATPKAKI 219

Query: 188 ILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGI 244
            L+FL + +EH        +CK +++ ++DG   +  L  K+C T   +++   TGI
Sbjct: 220 YLRFLDYQMEH------SNECKRNFVAVYDGSSSIENLKAKFCST-VANDVMLKTGI 269



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 38/114 (33%), Positives = 61/114 (53%), Gaps = 5/114 (4%)

Query: 154 TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWL 213
           TS  G   SP +P+ YP N +C + + A P+  I L F     EH  ++    +C++D L
Sbjct: 51  TSNGGHFASPNYPDSYPPNKECIYILEAAPRQRIELTFD----EHYYIEPSF-ECRFDHL 105

Query: 214 DIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
           ++ DG     PLI +YCG K+P  +RS+   + + F +D  +   GF A+Y  +
Sbjct: 106 EVRDGPFGFSPLIDRYCGVKSPPLIRSTGRFMWIKFSSDEELEGLGFRAKYSFI 159


>gi|167830477 milk fat globule-EGF factor 8 protein isoform b [Homo
           sapiens]
          Length = 335

 Score =  124 bits (312), Expect = 3e-28
 Identities = 96/330 (29%), Positives = 151/330 (45%), Gaps = 76/330 (23%)

Query: 276 QCNVPLGMESGRIANEQISASSTYSD----GRWTPQQSRLH--GDDNGWTPNLDSNKEYL 329
           +C  PLG+E+G IAN QI+ASS          W P+ +RL+  G  N WTP+ + +  ++
Sbjct: 69  KCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARLNRAGMVNAWTPSSNDDNPWI 128

Query: 330 QVDLRFLTMLTAIATQGAISRETQNGYYVKSYKLEVSTNGEDW-MVYRHGKNHKVFQANN 388
           QV+L     +T + TQGA    +    Y+K++K+  S NG ++  ++   K HK F  N 
Sbjct: 129 QVNLLRRMWVTGVVTQGASRLASHE--YLKAFKVAYSLNGHEFDFIHDVNKKHKEFVGNW 186

Query: 389 DATEVVLNKLHAPLLTRFVRIRPQTWHSGIALRLELFGCRVTDAPCSNMLGMLSGLIADS 448
           +   V +N    P+  ++VR+ P + H+   LR EL GC +    C+N LG+ +  I D 
Sbjct: 187 NKNAVHVNLFETPVEAQYVRLYPTSCHTACTLRFELLGCELNG--CANPLGLKNNSIPDK 244

Query: 449 QISASSTQE------YLWSPSAARLVSSRSGWFPRIPQAQPGEEWLQVDLGTPKTVKGVI 502
           QI+ASS+ +      + W+PS ARL   +  +   +  +   ++WLQ+  G         
Sbjct: 245 QITASSSYKTWGLHLFSWNPSYARL-DKQGNFNAWVAGSYGNDQWLQIFPG--------- 294

Query: 503 IQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQQPKLFEGNMHYDTPDIRR 562
                                          +W    D  + +  LFE            
Sbjct: 295 -------------------------------NW----DNHSHKKNLFE------------ 307

Query: 563 FDPIPAQYVRVYPERWSPAGIGMRLEVLGC 592
             PI A+YVR+ P  W    I +RLE+LGC
Sbjct: 308 -TPILARYVRILPVAWHNR-IALRLELLGC 335



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 59/170 (34%), Positives = 93/170 (54%), Gaps = 17/170 (10%)

Query: 431 DAPCSNMLGMLSGLIADSQISASSTQEYL-----WSPSAARLVSSRSGWFPR-IPQAQPG 484
           +  C   LG+ +G IA+SQI+ASS +        W P  ARL  +R+G      P +   
Sbjct: 67  ETKCVEPLGLENGNIANSQIAASSVRVTFLGLQHWVPELARL--NRAGMVNAWTPSSNDD 124

Query: 485 EEWLQVDLGTPKTVKGVIIQGARGGDSITAVEARAFVRKFKVSYSLNGKDWEYIQDPRTQ 544
             W+QV+L     V GV+ QGA      + + +  +++ FKV+YSLNG ++++I D   +
Sbjct: 125 NPWIQVNLLRRMWVTGVVTQGA------SRLASHEYLKAFKVAYSLNGHEFDFIHDV-NK 177

Query: 545 QPKLFEGNMHYDTPDIRRFD-PIPAQYVRVYPERWSPAGIGMRLEVLGCD 593
           + K F GN + +   +  F+ P+ AQYVR+YP     A   +R E+LGC+
Sbjct: 178 KHKEFVGNWNKNAVHVNLFETPVEAQYVRLYPTSCHTA-CTLRFELLGCE 226


>gi|20373181 neuropilin- and tolloid-like protein 1 isoform 3
           precursor [Homo sapiens]
          Length = 533

 Score =  113 bits (282), Expect = 9e-25
 Identities = 81/287 (28%), Positives = 129/287 (44%), Gaps = 29/287 (10%)

Query: 23  QPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH- 81
           Q    CG      + G  TSP YP  YP  + C +I+ A  P Q I L F+  + IE   
Sbjct: 36  QKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAA-PRQCIELYFDEKYSIEPSW 94

Query: 82  DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEI 141
           +CK+D IE+RDG    + ++G+ CG   PP I SSG  L+IKF +D   +  GFS RY  
Sbjct: 95  ECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNF 154

Query: 142 FKTGSED------------CSKNFTSPNGTIESPGFPEK----YPHNLDCTFTILAKPKM 185
             T   D            C        G +ES    ++        +DC + I A P+ 
Sbjct: 155 --TPDPDFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRS 212

Query: 186 EIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGIL 245
           +I L+FL +++++        +CK +++ ++DG   V  L  K+C T   +++   TG+ 
Sbjct: 213 KIYLRFLDYEMQN------SNECKRNFVAVYDGSSSVEDLKAKFCST-VANDVMLRTGLG 265

Query: 246 SLTFHTDMAVAKDGFSARYYLVHQEPLE--NFQCNVPLGMESGRIAN 290
            +    D       F   +    + P E   F C+  + + +  + N
Sbjct: 266 VIRMWADEGSRNSRFQMLFTSFQEPPCEGNTFFCHSNMCINNTLVCN 312


>gi|23510396 neuropilin- and tolloid-like protein 1 isoform 2
           precursor [Homo sapiens]
          Length = 532

 Score =  113 bits (282), Expect = 9e-25
 Identities = 81/287 (28%), Positives = 129/287 (44%), Gaps = 29/287 (10%)

Query: 23  QPDPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKH- 81
           Q    CG      + G  TSP YP  YP  + C +I+ A  P Q I L F+  + IE   
Sbjct: 35  QKSVQCGTWTKHAEGGIFTSPNYPSKYPPDRECIYIIEAA-PRQCIELYFDEKYSIEPSW 93

Query: 82  DCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEI 141
           +CK+D IE+RDG    + ++G+ CG   PP I SSG  L+IKF +D   +  GFS RY  
Sbjct: 94  ECKFDHIEVRDGPFGFSPIIGRFCGQQNPPVIKSSGRFLWIKFFADGELESMGFSARYNF 153

Query: 142 FKTGSED------------CSKNFTSPNGTIESPGFPEK----YPHNLDCTFTILAKPKM 185
             T   D            C        G +ES    ++        +DC + I A P+ 
Sbjct: 154 --TPDPDFKDLGALKPLPACEFEMGGSEGIVESIQIMKEGKATASEAVDCKWYIRAPPRS 211

Query: 186 EIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGIL 245
           +I L+FL +++++        +CK +++ ++DG   V  L  K+C T   +++   TG+ 
Sbjct: 212 KIYLRFLDYEMQN------SNECKRNFVAVYDGSSSVEDLKAKFCST-VANDVMLRTGLG 264

Query: 246 SLTFHTDMAVAKDGFSARYYLVHQEPLE--NFQCNVPLGMESGRIAN 290
            +    D       F   +    + P E   F C+  + + +  + N
Sbjct: 265 VIRMWADEGSRNSRFQMLFTSFQEPPCEGNTFFCHSNMCINNTLVCN 311


>gi|38045890 CUB and Sushi multiple domains 3 isoform 2 [Homo
           sapiens]
          Length = 3667

 Score =  110 bits (274), Expect = 8e-24
 Identities = 85/294 (28%), Positives = 129/294 (43%), Gaps = 72/294 (24%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CG  L    +G  TSP +P  Y S+  C W++ A   N+ I +NF   F++E     YD 
Sbjct: 508 CGSNLQGP-SGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFE-EFDLE---IGYDT 562

Query: 88  IEIRDGDS--ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA---------------- 129
           + I DG    +   +L    G+  P  I+S  S +++   +D +                
Sbjct: 563 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 622

Query: 130 ------------RQGAGFS----LRYEI---FKTGSED--------------------CS 150
                       R+G GFS    LR+E    F+   E                     C 
Sbjct: 623 SCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCL 682

Query: 151 KNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKY 210
            NFT+P GT+ SP +PE Y +NL+C +TI++ P   I L F  FDLE           ++
Sbjct: 683 SNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE----------SQF 732

Query: 211 DWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
           D+L + DG     P++G + G + PS L S++ IL L F  D +++  GF+  Y
Sbjct: 733 DFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY 786



 Score =  109 bits (272), Expect = 1e-23
 Identities = 86/322 (26%), Positives = 134/322 (41%), Gaps = 77/322 (23%)

Query: 38  GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSES 97
           G + SP YP+ Y ++ NC W + + +P  +I L+FN  F++E    ++DF+ ++DGDS  
Sbjct: 690 GTVLSPDYPEGYGNNLNCIWTIIS-DPGSRIHLSFND-FDLES---QFDFLAVKDGDSPE 744

Query: 98  ADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIF--------------- 142
           + +LG   G   P  + S+  +L ++F +D++  G GF++ Y  F               
Sbjct: 745 SPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINAR 804

Query: 143 ---------KTGSEDCSKNFTSPNGT---------------------------------- 159
                     + S  C + F    GT                                  
Sbjct: 805 RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSG 864

Query: 160 -IESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG 218
            I SPG+P  Y  +L+C + I A+P   I + F  F  E            YD L++ DG
Sbjct: 865 VILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----------LNYDVLEVHDG 914

Query: 219 IPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCN 278
              + PL+G Y GT+ P  L SS+  + L F TD + + +GF   Y  V    +  + C 
Sbjct: 915 PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV---TVNTYSCL 971

Query: 279 VPLGMESGRIANEQISASSTYS 300
            P     GR      S  ST S
Sbjct: 972 DPGIPVHGRRYGHDFSIGSTVS 993



 Score =  106 bits (265), Expect = 9e-23
 Identities = 92/333 (27%), Positives = 133/333 (39%), Gaps = 82/333 (24%)

Query: 27   PCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPN--QKIVLNFNPHFEIEKHDCK 84
            PCGG L +K  G I SPGYP+ Y ++ NC W +  PE    Q  V++F       +H+  
Sbjct: 1898 PCGGIL-TKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSF-----ATEHN-- 1949

Query: 85   YDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSL------- 137
            +D ++  DG   +A  LG + G   P  + S+ + LY+ F SD +   AGF L       
Sbjct: 1950 WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGL 2009

Query: 138  -----------------RYEIFKTGSEDCSK--------------------NFTSP---- 156
                             RY +    S  C +                    N+  P    
Sbjct: 2010 DSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2069

Query: 157  ---------NGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
                     +G I SPGFP  YP +LDCT+TI       + LQF+ F  E          
Sbjct: 2070 QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE---------- 2119

Query: 208  CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
              +D+L++  G      +IG+  G + PS L S+T   SL FH+D +  K GF   Y   
Sbjct: 2120 TIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAY 2179

Query: 268  HQEPLENFQCNVPLGMESGRIANEQISASSTYS 300
              +      C  P    +G +     +   T S
Sbjct: 2180 QLQ-----SCPDPRPFRNGFVIGNDFTVGQTIS 2207



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 83/295 (28%), Positives = 120/295 (40%), Gaps = 73/295 (24%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
            CGGR   + +G I SPGYP  Y ++  C W++   +P   + L F   F+ E     +D 
Sbjct: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEV-DPGNIVSLQFLA-FDTE---ASHDI 1428

Query: 88   IEIRDGDSESADLLGKHCGNIAPPTIIS---------------SGSMLYIKFTSDYA--- 129
            + + DG  E+  LL +  G++ P  I S               S S   I+F+S  A   
Sbjct: 1429 LRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATAC 1488

Query: 130  ----------RQG--------------AGFSLRYEIFKTGSE----------------DC 149
                      R G               G+ L+ E   T  +                 C
Sbjct: 1489 RDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1548

Query: 150  SKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCK 209
              N T  +G I SP FP  YPH+ DC +TI       I L F+ F +E +          
Sbjct: 1549 GGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN---------- 1598

Query: 210  YDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
            YD+L I+DG     PLIG +  +K P  + SS+  + L F +D +V+  GF   Y
Sbjct: 1599 YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1653



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 81/308 (26%), Positives = 126/308 (40%), Gaps = 77/308 (25%)

Query: 27   PCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYD 86
            PCGG   S  +G I SPG+P  Y    NCEW++ A EP   I + F   F+ E +   YD
Sbjct: 854  PCGGHF-SAPSGVILSPGWPGYYKDSLNCEWVIEA-EPGHSIKITFE-RFQTELN---YD 907

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEI----- 141
             +E+ DG +  + LLG + G   P  + SS + +Y+ FT+D +R   GF + YE      
Sbjct: 908  VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 967

Query: 142  ------------------FKTGSED-----------------CSKN--FTSP-------- 156
                              F  GS                   C KN  ++ P        
Sbjct: 968  YSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALC 1027

Query: 157  NGTIESP-------GFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCK 209
             G +  P       G+PE YP++L+CT+T+       +   F  F LE            
Sbjct: 1028 GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----------H 1077

Query: 210  YDWLDIWDGIPHVGPLIGKYCGTKTPSELRS---STGILSLTFHTDMAVAKDGFSARYYL 266
            +D+L I +      PL  +  G+  P  + +         L F +D +++ +GF+  +  
Sbjct: 1078 HDYLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE 1136

Query: 267  VHQEPLEN 274
             + EP E+
Sbjct: 1137 YNLEPCED 1144



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 41/116 (35%), Positives = 66/116 (56%), Gaps = 7/116 (6%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
            CGG + + + G I SPGYP +YP+ Q+C W+V  P P   I +NF     + + +  YDF
Sbjct: 2243 CGGNITAMN-GTIYSPGYPDEYPNFQDCFWLVRVP-PGNGIYINFT----VLQTEPIYDF 2296

Query: 88   IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
            I + DG  +++  +G+  GN A  ++ S+ + + IKF SD+   G  F L Y  ++
Sbjct: 2297 ITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGF-FVLSYHAYQ 2351



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 44/132 (33%), Positives = 64/132 (48%), Gaps = 15/132 (11%)

Query: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
           C       NGTIESPGFP  YP+  +CT+ I+A+ +  I + F  F LE +         
Sbjct: 25  CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE--------- 75

Query: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
            YD+L ++DG PH      +  G   P  + S+  + SL   +D AV+  GF      V+
Sbjct: 76  -YDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFK-----VY 129

Query: 269 QEPLENFQCNVP 280
            E L++  C  P
Sbjct: 130 YEELQSSSCGNP 141



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 69/297 (23%), Positives = 118/297 (39%), Gaps = 77/297 (25%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
            CG    + + G + SP YP +Y ++  C   +Y+ +      +N +       H  + D 
Sbjct: 1201 CGASATNNE-GILLSPNYPLNYENNHEC---IYSIQVQAGKGINISAR---TFHLAQGDV 1253

Query: 88   IEIRDGDSESADLLGKHCG-NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK-TG 145
            ++I DG  ++  LLG   G ++   T+ S+ + L+++F SD      GF L Y  F+ + 
Sbjct: 1254 LKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1313

Query: 146  SED------------------------CSKNFTSPNGTI--------------------- 160
             ED                        C+  +T    ++                     
Sbjct: 1314 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1373

Query: 161  -------ESPG------FPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
                   ES G      +P  Y +NL C + I   P   + LQFL FD E          
Sbjct: 1374 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE---------- 1423

Query: 208  CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
              +D L +WDG P    L+ +  G+  P  + S+  I+++ F TD  ++K GF+ ++
Sbjct: 1424 ASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1480



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 44/138 (31%), Positives = 69/138 (50%), Gaps = 8/138 (5%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CGG L   + G I SPG+P  YP+  NC W++ A E N +I + F   F +E+   +YD+
Sbjct: 25  CGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERN-RIQIVFQS-FALEE---EYDY 78

Query: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
           + + DG     +   +  G   PP + S+ S+  ++ TSD+A    GF + YE  ++ S 
Sbjct: 79  LSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSS- 137

Query: 148 DCSKNFTSPNGTIESPGF 165
            C      P G +    F
Sbjct: 138 -CGNPGVPPKGVLYGTRF 154



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 83/345 (24%), Positives = 128/345 (37%), Gaps = 85/345 (24%)

Query: 23   QPDPP-----CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFE 77
            QP PP     CGG L    +G+I SP +P  YP  ++C+W +     +  I L F   F 
Sbjct: 1538 QPSPPVCIAPCGGNLTGS-SGFILSPNFPHPYPHSRDCDWTITV-NADYVISLAFIS-FS 1594

Query: 78   IEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISS-----------GSMLYIKFTS 126
            IE +   YDF+ I DG   ++ L+G    +  P  I SS           GS+ Y  F  
Sbjct: 1595 IEPN---YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHL 1651

Query: 127  DYARQ-------------GAGFSLRYEIFKTGSEDCSKNF-------------------- 153
            +Y  +             G    + Y++  T +  C   +                    
Sbjct: 1652 EYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGW 1711

Query: 154  ---------------TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE- 197
                           T   GT+ SP +P+ Y    +C ++I    +  +  QF+ F    
Sbjct: 1712 NRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL 1771

Query: 198  HDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAK 257
            HD ++V +G  +   L        +  L G + G   P    SS   +++ F +   +  
Sbjct: 1772 HDVVEVYDGPTQQSSL--------LSSLSGSHSGESLP---LSSGNQITIRFTSVGPITA 1820

Query: 258  DGFSARYYLVHQEPLENFQC-NVPLGMESGRIANEQISASSTYSD 301
             GF   Y  V +    + QC +VP      RI NE    SS   D
Sbjct: 1821 KGFHFVYQAVPR--TSSTQCSSVPEPRFGRRIGNEFAVGSSVLFD 1863



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 12/121 (9%)

Query: 149  CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
            C  N T+ NGTI SPG+P++YP+  DC + +   P   I + F +  L+ +P+       
Sbjct: 2243 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTV--LQTEPI------- 2293

Query: 209  KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
             YD++ +WDG     P IG++ G      + S++  + + FH+D   +  GF    Y  +
Sbjct: 2294 -YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFVLSYHAY 2350

Query: 269  Q 269
            Q
Sbjct: 2351 Q 2351



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 38/113 (33%), Positives = 61/113 (53%), Gaps = 10/113 (8%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CGG +    +G I+SP +P +Y ++ +C W + A EP   I L F   F++E+   KYD+
Sbjct: 201 CGGTMRGS-SGIISSPSFPNEYHNNADCTWTIVA-EPGDTISLIFT-DFQMEE---KYDY 254

Query: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYE 140
           +EI   +  +  L G +     PP IIS+ + L + F +D   +  GFS  Y+
Sbjct: 255 LEIEGSEPPTIWLSGMN----IPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQ 303



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 70/301 (23%), Positives = 113/301 (37%), Gaps = 79/301 (26%)

Query: 25   DPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCK 84
            D  CGG +    +G I SPGYP+ YP+  NC W V      + +  NF+  F +E H   
Sbjct: 1024 DALCGGDVRGP-SGTILSPGYPEFYPNSLNCTWTVDVTH-GKGVQFNFHT-FHLEDH--- 1077

Query: 85   YDFIEIRDGDSESADLLGKHCGNIAPPTI---ISSGSMLYIKFTSDYARQGAGFSLRYE- 140
            +D++ I +  S +   L +  G+  PPTI   +       ++F SD++    GF++ +  
Sbjct: 1078 HDYLLITENGSFTQP-LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE 1136

Query: 141  -----------------------IFKTGSEDCSKNF------------------------ 153
                                   I  T +  CS  +                        
Sbjct: 1137 YNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPR 1196

Query: 154  ---------TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
                     T+  G + SP +P  Y +N +C ++I  +    I +    F L        
Sbjct: 1197 CVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-------A 1249

Query: 205  EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPS-ELRSSTGILSLTFHTDMAVAKDGFSAR 263
            +GD     L I+DG      L+G + G       L S++  L L F++D     +GF   
Sbjct: 1250 QGDV----LKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLV 1305

Query: 264  Y 264
            Y
Sbjct: 1306 Y 1306



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 17/152 (11%)

Query: 17   RHQVRGQPDPPC-----GGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
            R Q+ G P P C        L     G I SPGYP  YP+ Q C W + + E    I + 
Sbjct: 2402 RLQMDGAP-PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSI-SVEKGYNITM- 2458

Query: 72   FNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPP-TIISSGSMLYIKFTSDYAR 130
            F   F+ EK   ++D +++ DG +  + +L    G+ +    I S+G  +++++++D+  
Sbjct: 2459 FVEFFQTEK---EFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGN 2515

Query: 131  QGAGFSLRYEIFKTGSEDCSKNFTSPNGTIES 162
               GF +RY  F      CS   + P+G I S
Sbjct: 2516 NKKGFRIRYIAFY-----CSTPESPPHGYIIS 2542



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 42/116 (36%), Positives = 53/116 (45%), Gaps = 14/116 (12%)

Query: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
           C       +G I SP FP +Y +N DCT+TI+A+P   I L F  F +E           
Sbjct: 201 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE---------- 250

Query: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
           KYD+L+I    P   P I    G   P  + S+   L L F TD      GFSA Y
Sbjct: 251 KYDYLEIEGSEP---PTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 302



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 24/170 (14%)

Query: 115 SSGSMLYIKFTSDYARQGAGFSLRY---EIFKTGSED--------CSKNFTSPNGTIESP 163
           S GS +      DY  QGA         E+F   S+         C  N   P+GT  SP
Sbjct: 463 SLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSP 522

Query: 164 GFPEKYPHNLDCTFTILAKPKMEII-LQFLIFDLE--HDPLQVGEGDCKYDWLDIWDGIP 220
            FP +Y  N  C + I A    ++I + F  FDLE  +D L +G+G       ++ D   
Sbjct: 523 NFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGG------EVGDPRT 576

Query: 221 HVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQE 270
            +  L G +     P  + S +  + L   TD +V   GF   Y  + +E
Sbjct: 577 VLQVLTGSF----VPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 622



 Score = 37.0 bits (84), Expect = 0.084
 Identities = 32/135 (23%), Positives = 54/135 (40%), Gaps = 19/135 (14%)

Query: 158  GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD 217
            G I SPG+P+ YP+   C ++I  +    I +    F  E +          +D L ++D
Sbjct: 2427 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----------FDVLQVYD 2476

Query: 218  GIPHVGPLIGKYCGTKTPS-ELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQ 276
            G     P++    G  + +  + S+   + L +  D    K GF  RY          F 
Sbjct: 2477 GPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA--------FY 2528

Query: 277  CNVPLGMESGRIANE 291
            C+ P     G I ++
Sbjct: 2529 CSTPESPPHGYIISQ 2543


>gi|205277354 CUB and Sushi multiple domains 3 isoform 3 [Homo
           sapiens]
          Length = 3538

 Score =  110 bits (274), Expect = 8e-24
 Identities = 85/294 (28%), Positives = 129/294 (43%), Gaps = 72/294 (24%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CG  L    +G  TSP +P  Y S+  C W++ A   N+ I +NF   F++E     YD 
Sbjct: 444 CGSNLQGP-SGTFTSPNFPFQYDSNAQCVWVITAVNTNKVIQINFE-EFDLE---IGYDT 498

Query: 88  IEIRDGDS--ESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYA---------------- 129
           + I DG    +   +L    G+  P  I+S  S +++   +D +                
Sbjct: 499 LTIGDGGEVGDPRTVLQVLTGSFVPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 558

Query: 130 ------------RQGAGFS----LRYEI---FKTGSED--------------------CS 150
                       R+G GFS    LR+E    F+   E                     C 
Sbjct: 559 SCGDPGTPLYGIREGDGFSNRDVLRFECQFGFELIGEKSIVCQENNQWSANIPICIFPCL 618

Query: 151 KNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKY 210
            NFT+P GT+ SP +PE Y +NL+C +TI++ P   I L F  FDLE           ++
Sbjct: 619 SNFTAPMGTVLSPDYPEGYGNNLNCIWTIISDPGSRIHLSFNDFDLE----------SQF 668

Query: 211 DWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
           D+L + DG     P++G + G + PS L S++ IL L F  D +++  GF+  Y
Sbjct: 669 DFLAVKDGDSPESPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITY 722



 Score =  109 bits (272), Expect = 1e-23
 Identities = 86/322 (26%), Positives = 134/322 (41%), Gaps = 77/322 (23%)

Query: 38  GYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDFIEIRDGDSES 97
           G + SP YP+ Y ++ NC W + + +P  +I L+FN  F++E    ++DF+ ++DGDS  
Sbjct: 626 GTVLSPDYPEGYGNNLNCIWTIIS-DPGSRIHLSFND-FDLES---QFDFLAVKDGDSPE 680

Query: 98  ADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIF--------------- 142
           + +LG   G   P  + S+  +L ++F +D++  G GF++ Y  F               
Sbjct: 681 SPILGTFTGAEVPSHLTSNSHILRLEFQADHSMSGRGFNITYNTFGHNECPDPGIPINAR 740

Query: 143 ---------KTGSEDCSKNFTSPNGT---------------------------------- 159
                     + S  C + F    GT                                  
Sbjct: 741 RFGDNFQLGSSISVICEEGFIKTQGTETITCILMDGKVMWSGLIPKCGAPCGGHFSAPSG 800

Query: 160 -IESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWDG 218
            I SPG+P  Y  +L+C + I A+P   I + F  F  E            YD L++ DG
Sbjct: 801 VILSPGWPGYYKDSLNCEWVIEAEPGHSIKITFERFQTE----------LNYDVLEVHDG 850

Query: 219 IPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQCN 278
              + PL+G Y GT+ P  L SS+  + L F TD + + +GF   Y  V    +  + C 
Sbjct: 851 PNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESV---TVNTYSCL 907

Query: 279 VPLGMESGRIANEQISASSTYS 300
            P     GR      S  ST S
Sbjct: 908 DPGIPVHGRRYGHDFSIGSTVS 929



 Score =  106 bits (265), Expect = 9e-23
 Identities = 92/333 (27%), Positives = 133/333 (39%), Gaps = 82/333 (24%)

Query: 27   PCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPN--QKIVLNFNPHFEIEKHDCK 84
            PCGG L +K  G I SPGYP+ Y ++ NC W +  PE    Q  V++F       +H+  
Sbjct: 1834 PCGGIL-TKRKGTILSPGYPEPYDNNLNCVWKITVPEGAGIQVQVVSF-----ATEHN-- 1885

Query: 85   YDFIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSL------- 137
            +D ++  DG   +A  LG + G   P  + S+ + LY+ F SD +   AGF L       
Sbjct: 1886 WDSLDFYDGGDNNAPRLGSYSGTTIPHLLNSTSNNLYLNFQSDISVSAAGFHLEYTAIGL 1945

Query: 138  -----------------RYEIFKTGSEDCSK--------------------NFTSP---- 156
                             RY +    S  C +                    N+  P    
Sbjct: 1946 DSCPEPQTPSSGIKIGDRYMVGDVVSFQCDQGYSLQGHSHITCMPGPVRRWNYPIPICLA 2005

Query: 157  ---------NGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
                     +G I SPGFP  YP +LDCT+TI       + LQF+ F  E          
Sbjct: 2006 QCGGAMSDFSGVILSPGFPGNYPSSLDCTWTINLPIGFGVHLQFVNFSTE---------- 2055

Query: 208  CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLV 267
              +D+L++  G      +IG+  G + PS L S+T   SL FH+D +  K GF   Y   
Sbjct: 2056 TIHDYLEVRSGSSETSTVIGRLSGPQIPSSLFSTTHETSLYFHSDYSQNKQGFHIVYQAY 2115

Query: 268  HQEPLENFQCNVPLGMESGRIANEQISASSTYS 300
              +      C  P    +G +     +   T S
Sbjct: 2116 QLQ-----SCPDPRPFRNGFVIGNDFTVGQTIS 2143



 Score = 97.4 bits (241), Expect = 5e-20
 Identities = 83/295 (28%), Positives = 120/295 (40%), Gaps = 73/295 (24%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
            CGGR   + +G I SPGYP  Y ++  C W++   +P   + L F   F+ E     +D 
Sbjct: 1310 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEV-DPGNIVSLQFLA-FDTE---ASHDI 1364

Query: 88   IEIRDGDSESADLLGKHCGNIAPPTIIS---------------SGSMLYIKFTSDYA--- 129
            + + DG  E+  LL +  G++ P  I S               S S   I+F+S  A   
Sbjct: 1365 LRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQFSSSVATAC 1424

Query: 130  ----------RQG--------------AGFSLRYEIFKTGSE----------------DC 149
                      R G               G+ L+ E   T  +                 C
Sbjct: 1425 RDPGVPMNGTRNGDGREPGDTVVFQCDPGYELQGEERITCIQVENRYFWQPSPPVCIAPC 1484

Query: 150  SKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCK 209
              N T  +G I SP FP  YPH+ DC +TI       I L F+ F +E +          
Sbjct: 1485 GGNLTGSSGFILSPNFPHPYPHSRDCDWTITVNADYVISLAFISFSIEPN---------- 1534

Query: 210  YDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
            YD+L I+DG     PLIG +  +K P  + SS+  + L F +D +V+  GF   Y
Sbjct: 1535 YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHLEY 1589



 Score = 90.1 bits (222), Expect = 8e-18
 Identities = 81/308 (26%), Positives = 126/308 (40%), Gaps = 77/308 (25%)

Query: 27   PCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYD 86
            PCGG   S  +G I SPG+P  Y    NCEW++ A EP   I + F   F+ E +   YD
Sbjct: 790  PCGGHF-SAPSGVILSPGWPGYYKDSLNCEWVIEA-EPGHSIKITFE-RFQTELN---YD 843

Query: 87   FIEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEI----- 141
             +E+ DG +  + LLG + G   P  + SS + +Y+ FT+D +R   GF + YE      
Sbjct: 844  VLEVHDGPNLLSPLLGSYNGTQVPQFLFSSSNFIYLLFTTDNSRSNNGFKIHYESVTVNT 903

Query: 142  ------------------FKTGSED-----------------CSKN--FTSP-------- 156
                              F  GS                   C KN  ++ P        
Sbjct: 904  YSCLDPGIPVHGRRYGHDFSIGSTVSFSCDSGYRLSHEEPLLCEKNHWWSHPLPTCDALC 963

Query: 157  NGTIESP-------GFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCK 209
             G +  P       G+PE YP++L+CT+T+       +   F  F LE            
Sbjct: 964  GGDVRGPSGTILSPGYPEFYPNSLNCTWTVDVTHGKGVQFNFHTFHLED----------H 1013

Query: 210  YDWLDIWDGIPHVGPLIGKYCGTKTPSELRS---STGILSLTFHTDMAVAKDGFSARYYL 266
            +D+L I +      PL  +  G+  P  + +         L F +D +++ +GF+  +  
Sbjct: 1014 HDYLLITENGSFTQPL-ARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE 1072

Query: 267  VHQEPLEN 274
             + EP E+
Sbjct: 1073 YNLEPCED 1080



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 41/116 (35%), Positives = 66/116 (56%), Gaps = 7/116 (6%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
            CGG + + + G I SPGYP +YP+ Q+C W+V  P P   I +NF     + + +  YDF
Sbjct: 2179 CGGNITAMN-GTIYSPGYPDEYPNFQDCFWLVRVP-PGNGIYINFT----VLQTEPIYDF 2232

Query: 88   IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
            I + DG  +++  +G+  GN A  ++ S+ + + IKF SD+   G  F L Y  ++
Sbjct: 2233 ITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTSGF-FVLSYHAYQ 2287



 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 44/132 (33%), Positives = 64/132 (48%), Gaps = 15/132 (11%)

Query: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
           C       NGTIESPGFP  YP+  +CT+ I+A+ +  I + F  F LE +         
Sbjct: 65  CGGTLKGLNGTIESPGFPYGYPNGANCTWVIIAEERNRIQIVFQSFALEEE--------- 115

Query: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
            YD+L ++DG PH      +  G   P  + S+  + SL   +D AV+  GF      V+
Sbjct: 116 -YDYLSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFK-----VY 169

Query: 269 QEPLENFQCNVP 280
            E L++  C  P
Sbjct: 170 YEELQSSSCGNP 181



 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 69/297 (23%), Positives = 118/297 (39%), Gaps = 77/297 (25%)

Query: 28   CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
            CG    + + G + SP YP +Y ++  C   +Y+ +      +N +       H  + D 
Sbjct: 1137 CGASATNNE-GILLSPNYPLNYENNHEC---IYSIQVQAGKGINISAR---TFHLAQGDV 1189

Query: 88   IEIRDGDSESADLLGKHCG-NIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK-TG 145
            ++I DG  ++  LLG   G ++   T+ S+ + L+++F SD      GF L Y  F+ + 
Sbjct: 1190 LKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLVYTSFELSH 1249

Query: 146  SED------------------------CSKNFTSPNGTI--------------------- 160
             ED                        C+  +T    ++                     
Sbjct: 1250 CEDPGIPQFGYKISDQGHFAGSTIIYGCNPGYTLHGSSLLKCMTGERRAWDYPLPSCIAE 1309

Query: 161  -------ESPG------FPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGD 207
                   ES G      +P  Y +NL C + I   P   + LQFL FD E          
Sbjct: 1310 CGGRFKGESSGRILSPGYPFPYDNNLRCMWMIEVDPGNIVSLQFLAFDTE---------- 1359

Query: 208  CKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
              +D L +WDG P    L+ +  G+  P  + S+  I+++ F TD  ++K GF+ ++
Sbjct: 1360 ASHDILRVWDGPPENDMLLKEISGSLIPEGIHSTLNIVTIQFDTDFYISKSGFAIQF 1416



 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 44/138 (31%), Positives = 69/138 (50%), Gaps = 8/138 (5%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CGG L   + G I SPG+P  YP+  NC W++ A E N +I + F   F +E+   +YD+
Sbjct: 65  CGGTLKGLN-GTIESPGFPYGYPNGANCTWVIIAEERN-RIQIVFQS-FALEE---EYDY 118

Query: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFKTGSE 147
           + + DG     +   +  G   PP + S+ S+  ++ TSD+A    GF + YE  ++ S 
Sbjct: 119 LSLYDGHPHPTNFRTRLTGFHLPPPVTSTKSVFSLRLTSDFAVSAHGFKVYYEELQSSS- 177

Query: 148 DCSKNFTSPNGTIESPGF 165
            C      P G +    F
Sbjct: 178 -CGNPGVPPKGVLYGTRF 194



 Score = 70.1 bits (170), Expect = 9e-12
 Identities = 83/345 (24%), Positives = 128/345 (37%), Gaps = 85/345 (24%)

Query: 23   QPDPP-----CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFE 77
            QP PP     CGG L    +G+I SP +P  YP  ++C+W +     +  I L F   F 
Sbjct: 1474 QPSPPVCIAPCGGNLTGS-SGFILSPNFPHPYPHSRDCDWTITV-NADYVISLAFIS-FS 1530

Query: 78   IEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPPTIISS-----------GSMLYIKFTS 126
            IE +   YDF+ I DG   ++ L+G    +  P  I SS           GS+ Y  F  
Sbjct: 1531 IEPN---YDFLYIYDGPDSNSPLIGSFQDSKLPERIESSSNTMHLAFRSDGSVSYTGFHL 1587

Query: 127  DYARQ-------------GAGFSLRYEIFKTGSEDCSKNF-------------------- 153
            +Y  +             G    + Y++  T +  C   +                    
Sbjct: 1588 EYKAKLRESCFDPGNIMNGTRLGMDYKLGSTVTYYCDAGYVLQGYSTLTCIMGDDGRPGW 1647

Query: 154  ---------------TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLE- 197
                           T   GT+ SP +P+ Y    +C ++I    +  +  QF+ F    
Sbjct: 1648 NRALPSCHAPCGSRSTGSEGTVLSPNYPKNYSVGHNCVYSIAVPKEFVVFGQFVFFQTSL 1707

Query: 198  HDPLQVGEGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAK 257
            HD ++V +G  +   L        +  L G + G   P    SS   +++ F +   +  
Sbjct: 1708 HDVVEVYDGPTQQSSL--------LSSLSGSHSGESLP---LSSGNQITIRFTSVGPITA 1756

Query: 258  DGFSARYYLVHQEPLENFQC-NVPLGMESGRIANEQISASSTYSD 301
             GF   Y  V +    + QC +VP      RI NE    SS   D
Sbjct: 1757 KGFHFVYQAVPR--TSSTQCSSVPEPRFGRRIGNEFAVGSSVLFD 1799



 Score = 69.7 bits (169), Expect = 1e-11
 Identities = 37/121 (30%), Positives = 62/121 (51%), Gaps = 12/121 (9%)

Query: 149  CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
            C  N T+ NGTI SPG+P++YP+  DC + +   P   I + F +  L+ +P+       
Sbjct: 2179 CGGNITAMNGTIYSPGYPDEYPNFQDCFWLVRVPPGNGIYINFTV--LQTEPI------- 2229

Query: 209  KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVH 268
             YD++ +WDG     P IG++ G      + S++  + + FH+D   +  GF    Y  +
Sbjct: 2230 -YDFITVWDGPDQNSPQIGQFSGNTALESVYSTSNQILIKFHSDFTTS--GFFVLSYHAY 2286

Query: 269  Q 269
            Q
Sbjct: 2287 Q 2287



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 39/116 (33%), Positives = 63/116 (54%), Gaps = 10/116 (8%)

Query: 28  CGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCKYDF 87
           CGG +    +G I+SP +P +Y ++ +C W + A EP   I L F   F++E+   KYD+
Sbjct: 241 CGGTMRGS-SGIISSPSFPNEYHNNADCTWTIVA-EPGDTISLIFT-DFQMEE---KYDY 294

Query: 88  IEIRDGDSESADLLGKHCGNIAPPTIISSGSMLYIKFTSDYARQGAGFSLRYEIFK 143
           +EI   +  +  L G +     PP IIS+ + L + F +D   +  GFS  Y++ K
Sbjct: 295 LEIEGSEPPTIWLSGMN----IPPPIISNKNWLRLHFVTDSNHRYRGFSAPYQVKK 346



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 70/301 (23%), Positives = 113/301 (37%), Gaps = 79/301 (26%)

Query: 25   DPPCGGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLNFNPHFEIEKHDCK 84
            D  CGG +    +G I SPGYP+ YP+  NC W V      + +  NF+  F +E H   
Sbjct: 960  DALCGGDVRGP-SGTILSPGYPEFYPNSLNCTWTVDVTH-GKGVQFNFHT-FHLEDH--- 1013

Query: 85   YDFIEIRDGDSESADLLGKHCGNIAPPTI---ISSGSMLYIKFTSDYARQGAGFSLRYE- 140
            +D++ I +  S +   L +  G+  PPTI   +       ++F SD++    GF++ +  
Sbjct: 1014 HDYLLITENGSFTQP-LARLTGSDLPPTINAGLYGNFRAQLRFISDFSISYEGFNITFSE 1072

Query: 141  -----------------------IFKTGSEDCSKNF------------------------ 153
                                   I  T +  CS  +                        
Sbjct: 1073 YNLEPCEDPGIPQYGSRIGFNFGIGDTLTFSCSSGYRLEGTSEIICLGGGRRVWSAPLPR 1132

Query: 154  ---------TSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVG 204
                     T+  G + SP +P  Y +N +C ++I  +    I +    F L        
Sbjct: 1133 CVAECGASATNNEGILLSPNYPLNYENNHECIYSIQVQAGKGINISARTFHL-------A 1185

Query: 205  EGDCKYDWLDIWDGIPHVGPLIGKYCGTKTPS-ELRSSTGILSLTFHTDMAVAKDGFSAR 263
            +GD     L I+DG      L+G + G       L S++  L L F++D     +GF   
Sbjct: 1186 QGDV----LKIYDGKDKTTHLLGAFTGASMRGLTLSSTSNQLWLEFNSDTEGTDEGFQLV 1241

Query: 264  Y 264
            Y
Sbjct: 1242 Y 1242



 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 45/152 (29%), Positives = 73/152 (48%), Gaps = 17/152 (11%)

Query: 17   RHQVRGQPDPPC-----GGRLNSKDAGYITSPGYPQDYPSHQNCEWIVYAPEPNQKIVLN 71
            R Q+ G P P C        L     G I SPGYP  YP+ Q C W + + E    I + 
Sbjct: 2338 RLQMDGAP-PVCQVLCPANELRLDSTGVILSPGYPDSYPNLQMCAWSI-SVEKGYNITM- 2394

Query: 72   FNPHFEIEKHDCKYDFIEIRDGDSESADLLGKHCGNIAPP-TIISSGSMLYIKFTSDYAR 130
            F   F+ EK   ++D +++ DG +  + +L    G+ +    I S+G  +++++++D+  
Sbjct: 2395 FVEFFQTEK---EFDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGN 2451

Query: 131  QGAGFSLRYEIFKTGSEDCSKNFTSPNGTIES 162
               GF +RY  F      CS   + P+G I S
Sbjct: 2452 NKKGFRIRYIAFY-----CSTPESPPHGYIIS 2478



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 42/116 (36%), Positives = 53/116 (45%), Gaps = 14/116 (12%)

Query: 149 CSKNFTSPNGTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDC 208
           C       +G I SP FP +Y +N DCT+TI+A+P   I L F  F +E           
Sbjct: 241 CGGTMRGSSGIISSPSFPNEYHNNADCTWTIVAEPGDTISLIFTDFQMEE---------- 290

Query: 209 KYDWLDIWDGIPHVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARY 264
           KYD+L+I    P   P I    G   P  + S+   L L F TD      GFSA Y
Sbjct: 291 KYDYLEIEGSEP---PTIW-LSGMNIPPPIISNKNWLRLHFVTDSNHRYRGFSAPY 342



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 48/170 (28%), Positives = 70/170 (41%), Gaps = 24/170 (14%)

Query: 115 SSGSMLYIKFTSDYARQGAGFSLRY---EIFKTGSED--------CSKNFTSPNGTIESP 163
           S GS +      DY  QGA         E+F   S+         C  N   P+GT  SP
Sbjct: 399 SLGSTVQFSCDEDYVLQGAKSITCQRIAEVFAAWSDHRPVCKVKTCGSNLQGPSGTFTSP 458

Query: 164 GFPEKYPHNLDCTFTILAKPKMEII-LQFLIFDLE--HDPLQVGEGDCKYDWLDIWDGIP 220
            FP +Y  N  C + I A    ++I + F  FDLE  +D L +G+G       ++ D   
Sbjct: 459 NFPFQYDSNAQCVWVITAVNTNKVIQINFEEFDLEIGYDTLTIGDGG------EVGDPRT 512

Query: 221 HVGPLIGKYCGTKTPSELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQE 270
            +  L G +     P  + S +  + L   TD +V   GF   Y  + +E
Sbjct: 513 VLQVLTGSF----VPDLIVSMSSQMWLHLQTDESVGSVGFKVNYKEIEKE 558



 Score = 37.0 bits (84), Expect = 0.084
 Identities = 32/135 (23%), Positives = 54/135 (40%), Gaps = 19/135 (14%)

Query: 158  GTIESPGFPEKYPHNLDCTFTILAKPKMEIILQFLIFDLEHDPLQVGEGDCKYDWLDIWD 217
            G I SPG+P+ YP+   C ++I  +    I +    F  E +          +D L ++D
Sbjct: 2363 GVILSPGYPDSYPNLQMCAWSISVEKGYNITMFVEFFQTEKE----------FDVLQVYD 2412

Query: 218  GIPHVGPLIGKYCGTKTPS-ELRSSTGILSLTFHTDMAVAKDGFSARYYLVHQEPLENFQ 276
            G     P++    G  + +  + S+   + L +  D    K GF  RY          F 
Sbjct: 2413 GPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGFRIRYIA--------FY 2464

Query: 277  CNVPLGMESGRIANE 291
            C+ P     G I ++
Sbjct: 2465 CSTPESPPHGYIISQ 2479


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.135    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,850,468
Number of Sequences: 37866
Number of extensions: 1903406
Number of successful extensions: 5465
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 111
Number of HSP's successfully gapped in prelim test: 23
Number of HSP's that attempted gapping in prelim test: 4148
Number of HSP's gapped (non-prelim): 638
length of query: 909
length of database: 18,247,518
effective HSP length: 111
effective length of query: 798
effective length of database: 14,044,392
effective search space: 11207424816
effective search space used: 11207424816
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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