BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|41322916 plectin 1 isoform 6 [Homo sapiens] (4684 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|41322916 plectin 1 isoform 6 [Homo sapiens] 8983 0.0 gi|47607492 plectin 1 isoform 1 [Homo sapiens] 8631 0.0 gi|41322923 plectin 1 isoform 11 [Homo sapiens] 8630 0.0 gi|41322914 plectin 1 isoform 10 [Homo sapiens] 8630 0.0 gi|41322919 plectin 1 isoform 8 [Homo sapiens] 8630 0.0 gi|41322910 plectin 1 isoform 7 [Homo sapiens] 8630 0.0 gi|41322908 plectin 1 isoform 3 [Homo sapiens] 8630 0.0 gi|41322912 plectin 1 isoform 2 [Homo sapiens] 8630 0.0 gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi... 2703 0.0 gi|33188445 microfilament and actin filament cross-linker protei... 1378 0.0 gi|207452735 epiplakin 1 [Homo sapiens] 1268 0.0 gi|58530842 desmoplakin isoform II [Homo sapiens] 964 0.0 gi|58530840 desmoplakin isoform I [Homo sapiens] 964 0.0 gi|4502443 dystonin isoform 1e precursor [Homo sapiens] 921 0.0 gi|221316624 dystonin isoform 4 [Homo sapiens] 861 0.0 gi|221316622 dystonin isoform 3 [Homo sapiens] 861 0.0 gi|221316618 dystonin isoform 2 [Homo sapiens] 861 0.0 gi|34577047 dystonin isoform 1 [Homo sapiens] 861 0.0 gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] 861 0.0 gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] 787 0.0 gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 427 e-118 gi|45439327 periplakin [Homo sapiens] 413 e-114 gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 400 e-110 gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 397 e-109 gi|67782321 spectrin beta isoform a [Homo sapiens] 374 e-102 gi|67782319 spectrin beta isoform b [Homo sapiens] 372 e-102 gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 357 1e-97 gi|148746195 trichohyalin [Homo sapiens] 352 6e-96 gi|156104874 envoplakin [Homo sapiens] 350 1e-95 gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 304 2e-81 >gi|41322916 plectin 1 isoform 6 [Homo sapiens] Length = 4684 Score = 8983 bits (23310), Expect = 0.0 Identities = 4684/4684 (100%), Positives = 4684/4684 (100%) Query: 1 MVAGMLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGL 60 MVAGMLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGL Sbjct: 1 MVAGMLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGL 60 Query: 61 VRETFAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQ 120 VRETFAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQ Sbjct: 61 VRETFAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQ 120 Query: 121 GPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRV 180 GPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRV Sbjct: 121 GPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRV 180 Query: 181 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 240 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV Sbjct: 181 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 240 Query: 241 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 300 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK Sbjct: 241 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 300 Query: 301 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 360 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF Sbjct: 301 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 360 Query: 361 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 420 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE Sbjct: 361 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 420 Query: 421 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 480 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY Sbjct: 421 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 480 Query: 481 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 540 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM Sbjct: 481 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 540 Query: 541 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 600 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR Sbjct: 541 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 600 Query: 601 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 660 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR Sbjct: 601 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 660 Query: 661 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 720 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS Sbjct: 661 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 720 Query: 721 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 780 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD Sbjct: 721 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 780 Query: 781 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 840 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ Sbjct: 781 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 840 Query: 841 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 900 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL Sbjct: 841 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 900 Query: 901 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 960 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH Sbjct: 901 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 960 Query: 961 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 1020 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW Sbjct: 961 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 1020 Query: 1021 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1080 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA Sbjct: 1021 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1080 Query: 1081 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1140 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT Sbjct: 1081 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1140 Query: 1141 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1200 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL Sbjct: 1141 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1200 Query: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1260 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP Sbjct: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1260 Query: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ Sbjct: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320 Query: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA Sbjct: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380 Query: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP Sbjct: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440 Query: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1500 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA Sbjct: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1500 Query: 1501 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ Sbjct: 1501 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560 Query: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE Sbjct: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620 Query: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL Sbjct: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680 Query: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV Sbjct: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740 Query: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE Sbjct: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800 Query: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE Sbjct: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860 Query: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE Sbjct: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920 Query: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG Sbjct: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980 Query: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD Sbjct: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040 Query: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE Sbjct: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100 Query: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR Sbjct: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160 Query: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA Sbjct: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220 Query: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE Sbjct: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280 Query: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN Sbjct: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340 Query: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ Sbjct: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400 Query: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT Sbjct: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460 Query: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE Sbjct: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520 Query: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH Sbjct: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580 Query: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL Sbjct: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640 Query: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE Sbjct: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700 Query: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT Sbjct: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760 Query: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2820 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA Sbjct: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2820 Query: 2821 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV 2880 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV Sbjct: 2821 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV 2880 Query: 2881 RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2940 RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI Sbjct: 2881 RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2940 Query: 2941 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 3000 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT Sbjct: 2941 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 3000 Query: 3001 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 3060 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT Sbjct: 3001 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 3060 Query: 3061 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3120 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA Sbjct: 3061 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3120 Query: 3121 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3180 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA Sbjct: 3121 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3180 Query: 3181 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3240 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT Sbjct: 3181 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3240 Query: 3241 GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL 3300 GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL Sbjct: 3241 GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL 3300 Query: 3301 DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE 3360 DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE Sbjct: 3301 DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE 3360 Query: 3361 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK 3420 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK Sbjct: 3361 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK 3420 Query: 3421 VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE 3480 VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE Sbjct: 3421 VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE 3480 Query: 3481 LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3540 LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR Sbjct: 3481 LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3540 Query: 3541 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3600 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR Sbjct: 3541 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3600 Query: 3601 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3660 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY Sbjct: 3601 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3660 Query: 3661 RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS 3720 RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS Sbjct: 3661 RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS 3720 Query: 3721 TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV 3780 TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV Sbjct: 3721 TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV 3780 Query: 3781 RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT 3840 RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT Sbjct: 3781 RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT 3840 Query: 3841 LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS 3900 LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS Sbjct: 3841 LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS 3900 Query: 3901 AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA 3960 AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA Sbjct: 3901 AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA 3960 Query: 3961 YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL 4020 YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL Sbjct: 3961 YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL 4020 Query: 4021 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 4080 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT Sbjct: 4021 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 4080 Query: 4081 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4140 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK Sbjct: 4081 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4140 Query: 4141 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4200 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV Sbjct: 4141 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4200 Query: 4201 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE 4260 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE Sbjct: 4201 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE 4260 Query: 4261 KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI 4320 KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI Sbjct: 4261 KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI 4320 Query: 4321 SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF 4380 SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF Sbjct: 4321 SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF 4380 Query: 4381 RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV 4440 RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV Sbjct: 4381 RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV 4440 Query: 4441 DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR 4500 DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR Sbjct: 4441 DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR 4500 Query: 4501 TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ 4560 TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ Sbjct: 4501 TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ 4560 Query: 4561 KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS 4620 KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS Sbjct: 4561 KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS 4620 Query: 4621 GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE 4680 GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE Sbjct: 4621 GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE 4680 Query: 4681 SAVA 4684 SAVA Sbjct: 4681 SAVA 4684 >gi|47607492 plectin 1 isoform 1 [Homo sapiens] Length = 4574 Score = 8631 bits (22396), Expect = 0.0 Identities = 4520/4564 (99%), Positives = 4525/4564 (99%), Gaps = 7/4564 (0%) Query: 121 GPLGSPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRV 180 G GSP LP + R + + V +R + R DERDRV Sbjct: 18 GSSGSPSPGDTLPWNLGKTQRSRRSGGGAGSNGSVLDPAERAVIR-------IADERDRV 70 Query: 181 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 240 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV Sbjct: 71 QKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNV 130 Query: 241 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 300 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK Sbjct: 131 QIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEK 190 Query: 301 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 360 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF Sbjct: 191 LLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAF 250 Query: 361 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 420 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE Sbjct: 251 SVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQE 310 Query: 421 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 480 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY Sbjct: 311 YRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIY 370 Query: 481 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 540 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM Sbjct: 371 QSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQM 430 Query: 541 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 600 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR Sbjct: 431 EAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGR 490 Query: 601 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 660 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR Sbjct: 491 HPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLR 550 Query: 661 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 720 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS Sbjct: 551 YLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS 610 Query: 721 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 780 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD Sbjct: 611 PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFD 670 Query: 781 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 840 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ Sbjct: 671 WSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQ 730 Query: 841 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 900 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL Sbjct: 731 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 790 Query: 901 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 960 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH Sbjct: 791 LQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVH 850 Query: 961 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 1020 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW Sbjct: 851 KGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLW 910 Query: 1021 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 1080 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA Sbjct: 911 HQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA 970 Query: 1081 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1140 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT Sbjct: 971 GGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT 1030 Query: 1141 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1200 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL Sbjct: 1031 VHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTL 1090 Query: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1260 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP Sbjct: 1091 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1150 Query: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ Sbjct: 1151 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1210 Query: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA Sbjct: 1211 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1270 Query: 1381 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1440 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP Sbjct: 1271 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP 1330 Query: 1441 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1500 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA Sbjct: 1331 KVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLA 1390 Query: 1501 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1560 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ Sbjct: 1391 EVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQ 1450 Query: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE Sbjct: 1451 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1510 Query: 1621 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1680 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL Sbjct: 1511 EAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRL 1570 Query: 1681 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV Sbjct: 1571 QAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1630 Query: 1741 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1800 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE Sbjct: 1631 AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE 1690 Query: 1801 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1860 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE Sbjct: 1691 KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE 1750 Query: 1861 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1920 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE Sbjct: 1751 QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE 1810 Query: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG Sbjct: 1811 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1870 Query: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD Sbjct: 1871 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1930 Query: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE Sbjct: 1931 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1990 Query: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR Sbjct: 1991 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2050 Query: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2220 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA Sbjct: 2051 LRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA 2110 Query: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE Sbjct: 2111 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2170 Query: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN Sbjct: 2171 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2230 Query: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ Sbjct: 2231 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2290 Query: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2460 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT Sbjct: 2291 RFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT 2350 Query: 2461 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2520 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE Sbjct: 2351 RLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAE 2410 Query: 2521 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2580 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH Sbjct: 2411 RLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDH 2470 Query: 2581 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL Sbjct: 2471 DAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2530 Query: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE Sbjct: 2531 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2590 Query: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT Sbjct: 2591 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2650 Query: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2820 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA Sbjct: 2651 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELA 2710 Query: 2821 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV 2880 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV Sbjct: 2711 RREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPV 2770 Query: 2881 RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2940 RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI Sbjct: 2771 RNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2830 Query: 2941 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 3000 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT Sbjct: 2831 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2890 Query: 3001 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 3060 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT Sbjct: 2891 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2950 Query: 3061 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3120 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA Sbjct: 2951 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3010 Query: 3121 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3180 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA Sbjct: 3011 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3070 Query: 3181 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3240 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT Sbjct: 3071 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3130 Query: 3241 GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL 3300 GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL Sbjct: 3131 GYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCL 3190 Query: 3301 DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE 3360 DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE Sbjct: 3191 DEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEE 3250 Query: 3361 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK 3420 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK Sbjct: 3251 LYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEK 3310 Query: 3421 VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE 3480 VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE Sbjct: 3311 VIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSE 3370 Query: 3481 LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3540 LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR Sbjct: 3371 LGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3430 Query: 3541 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3600 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR Sbjct: 3431 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3490 Query: 3601 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3660 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY Sbjct: 3491 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3550 Query: 3661 RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS 3720 RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS Sbjct: 3551 RQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGS 3610 Query: 3721 TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV 3780 TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV Sbjct: 3611 TMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYV 3670 Query: 3781 RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT 3840 RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT Sbjct: 3671 RRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQT 3730 Query: 3841 LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS 3900 LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS Sbjct: 3731 LSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLS 3790 Query: 3901 AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA 3960 AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA Sbjct: 3791 AERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVA 3850 Query: 3961 YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL 4020 YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL Sbjct: 3851 YQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKL 3910 Query: 4021 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 4080 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT Sbjct: 3911 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3970 Query: 4081 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4140 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK Sbjct: 3971 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4030 Query: 4141 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4200 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV Sbjct: 4031 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4090 Query: 4201 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE 4260 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE Sbjct: 4091 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKE 4150 Query: 4261 KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI 4320 KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI Sbjct: 4151 KKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITI 4210 Query: 4321 SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF 4380 SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF Sbjct: 4211 SSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGF 4270 Query: 4381 RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV 4440 RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV Sbjct: 4271 RSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLV 4330 Query: 4441 DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR 4500 DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR Sbjct: 4331 DNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPR 4390 Query: 4501 TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ 4560 TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ Sbjct: 4391 TKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQ 4450 Query: 4561 KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS 4620 KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS Sbjct: 4451 KLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGS 4510 Query: 4621 GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE 4680 GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE Sbjct: 4511 GSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSASLGGPE 4570 Query: 4681 SAVA 4684 SAVA Sbjct: 4571 SAVA 4574 >gi|41322923 plectin 1 isoform 11 [Homo sapiens] Length = 4547 Score = 8630 bits (22394), Expect = 0.0 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 97 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED Sbjct: 98 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 157 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE Sbjct: 158 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 217 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL Sbjct: 218 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 277 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN Sbjct: 278 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI Sbjct: 338 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 397 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ Sbjct: 398 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 654 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 517 Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS Sbjct: 518 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE Sbjct: 578 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS Sbjct: 998 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297 Query: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357 Query: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417 Query: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477 Query: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537 Query: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597 Query: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657 Query: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717 Query: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777 Query: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837 Query: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897 Query: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957 Query: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017 Query: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077 Query: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137 Query: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197 Query: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317 Query: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377 Query: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497 Query: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557 Query: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617 Query: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677 Query: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2874 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2737 Query: 2875 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2934 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI Sbjct: 2738 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2797 Query: 2935 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2994 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN Sbjct: 2798 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2857 Query: 2995 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 3054 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF Sbjct: 2858 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2917 Query: 3055 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3114 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL Sbjct: 2918 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2977 Query: 3115 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3174 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK Sbjct: 2978 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3037 Query: 3175 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3234 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS Sbjct: 3038 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3097 Query: 3235 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3294 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA Sbjct: 3098 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3157 Query: 3295 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3354 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA Sbjct: 3158 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3217 Query: 3355 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3414 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG Sbjct: 3218 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3277 Query: 3415 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3474 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT Sbjct: 3278 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3337 Query: 3475 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF Sbjct: 3338 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3397 Query: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL Sbjct: 3398 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3457 Query: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT Sbjct: 3458 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3517 Query: 3655 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3714 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG Sbjct: 3518 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3577 Query: 3715 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3774 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL Sbjct: 3578 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3637 Query: 3775 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3834 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL Sbjct: 3638 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3697 Query: 3835 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3894 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL Sbjct: 3698 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3757 Query: 3895 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3954 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH Sbjct: 3758 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3817 Query: 3955 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 4014 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL Sbjct: 3818 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3877 Query: 4015 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 4074 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG Sbjct: 3878 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3937 Query: 4075 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4134 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG Sbjct: 3938 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3997 Query: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE Sbjct: 3998 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4057 Query: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC Sbjct: 4058 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4117 Query: 4255 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4314 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE Sbjct: 4118 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4177 Query: 4315 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4374 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS Sbjct: 4178 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4237 Query: 4375 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4434 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA Sbjct: 4238 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4297 Query: 4435 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4494 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC Sbjct: 4298 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4357 Query: 4495 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4554 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV Sbjct: 4358 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4417 Query: 4555 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4614 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP Sbjct: 4418 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4477 Query: 4615 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4674 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA Sbjct: 4478 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4537 Query: 4675 SLGGPESAVA 4684 SLGGPESAVA Sbjct: 4538 SLGGPESAVA 4547 >gi|41322914 plectin 1 isoform 10 [Homo sapiens] Length = 4551 Score = 8630 bits (22394), Expect = 0.0 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF Sbjct: 42 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 101 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED Sbjct: 102 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 161 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE Sbjct: 162 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 221 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL Sbjct: 222 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 281 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN Sbjct: 282 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 341 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI Sbjct: 342 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 401 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ Sbjct: 402 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 461 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 654 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL Sbjct: 462 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 521 Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS Sbjct: 522 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE Sbjct: 582 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 641 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ Sbjct: 642 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV Sbjct: 702 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ Sbjct: 762 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ Sbjct: 822 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL Sbjct: 882 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE Sbjct: 942 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1001 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS Sbjct: 1002 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301 Query: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1361 Query: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421 Query: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481 Query: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541 Query: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601 Query: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1661 Query: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR Sbjct: 1662 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1721 Query: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE Sbjct: 1722 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1781 Query: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841 Query: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901 Query: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961 Query: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021 Query: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081 Query: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141 Query: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201 Query: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2261 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2321 Query: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381 Query: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2441 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2501 Query: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR Sbjct: 2502 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561 Query: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621 Query: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT Sbjct: 2622 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681 Query: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2874 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG Sbjct: 2682 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2741 Query: 2875 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2934 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI Sbjct: 2742 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2801 Query: 2935 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2994 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN Sbjct: 2802 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2861 Query: 2995 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 3054 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF Sbjct: 2862 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2921 Query: 3055 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3114 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL Sbjct: 2922 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2981 Query: 3115 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3174 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK Sbjct: 2982 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3041 Query: 3175 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3234 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS Sbjct: 3042 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3101 Query: 3235 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3294 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA Sbjct: 3102 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3161 Query: 3295 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3354 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA Sbjct: 3162 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3221 Query: 3355 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3414 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG Sbjct: 3222 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3281 Query: 3415 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3474 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT Sbjct: 3282 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3341 Query: 3475 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF Sbjct: 3342 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3401 Query: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL Sbjct: 3402 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3461 Query: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT Sbjct: 3462 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3521 Query: 3655 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3714 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG Sbjct: 3522 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3581 Query: 3715 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3774 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL Sbjct: 3582 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3641 Query: 3775 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3834 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL Sbjct: 3642 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3701 Query: 3835 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3894 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL Sbjct: 3702 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3761 Query: 3895 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3954 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH Sbjct: 3762 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3821 Query: 3955 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 4014 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL Sbjct: 3822 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3881 Query: 4015 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 4074 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG Sbjct: 3882 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3941 Query: 4075 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4134 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG Sbjct: 3942 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4001 Query: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE Sbjct: 4002 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4061 Query: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC Sbjct: 4062 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4121 Query: 4255 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4314 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE Sbjct: 4122 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4181 Query: 4315 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4374 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS Sbjct: 4182 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4241 Query: 4375 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4434 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA Sbjct: 4242 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4301 Query: 4435 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4494 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC Sbjct: 4302 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4361 Query: 4495 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4554 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV Sbjct: 4362 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4421 Query: 4555 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4614 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP Sbjct: 4422 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4481 Query: 4615 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4674 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA Sbjct: 4482 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4541 Query: 4675 SLGGPESAVA 4684 SLGGPESAVA Sbjct: 4542 SLGGPESAVA 4551 >gi|41322919 plectin 1 isoform 8 [Homo sapiens] Length = 4547 Score = 8630 bits (22394), Expect = 0.0 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF Sbjct: 38 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 97 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED Sbjct: 98 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 157 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE Sbjct: 158 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 217 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL Sbjct: 218 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 277 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN Sbjct: 278 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 337 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI Sbjct: 338 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 397 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ Sbjct: 398 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 457 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 654 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL Sbjct: 458 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 517 Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS Sbjct: 518 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 577 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE Sbjct: 578 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 637 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ Sbjct: 638 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 697 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV Sbjct: 698 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 757 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ Sbjct: 758 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 817 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ Sbjct: 818 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 877 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL Sbjct: 878 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 937 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE Sbjct: 938 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 997 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS Sbjct: 998 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1057 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA Sbjct: 1058 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1117 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW Sbjct: 1118 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1177 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP Sbjct: 1178 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1237 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA Sbjct: 1238 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1297 Query: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE Sbjct: 1298 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1357 Query: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS Sbjct: 1358 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1417 Query: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA Sbjct: 1418 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1477 Query: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA Sbjct: 1478 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1537 Query: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ Sbjct: 1538 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1597 Query: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL Sbjct: 1598 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1657 Query: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR Sbjct: 1658 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1717 Query: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE Sbjct: 1718 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1777 Query: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE Sbjct: 1778 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1837 Query: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ Sbjct: 1838 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1897 Query: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED Sbjct: 1898 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1957 Query: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK Sbjct: 1958 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2017 Query: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD Sbjct: 2018 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2077 Query: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK Sbjct: 2078 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2137 Query: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE Sbjct: 2138 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2197 Query: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR Sbjct: 2198 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2257 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ Sbjct: 2258 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2317 Query: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE Sbjct: 2318 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2377 Query: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ Sbjct: 2378 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2437 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS Sbjct: 2438 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2497 Query: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR Sbjct: 2498 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2557 Query: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA Sbjct: 2558 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2617 Query: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT Sbjct: 2618 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2677 Query: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2874 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG Sbjct: 2678 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2737 Query: 2875 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2934 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI Sbjct: 2738 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2797 Query: 2935 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2994 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN Sbjct: 2798 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2857 Query: 2995 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 3054 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF Sbjct: 2858 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2917 Query: 3055 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3114 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL Sbjct: 2918 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2977 Query: 3115 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3174 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK Sbjct: 2978 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3037 Query: 3175 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3234 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS Sbjct: 3038 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3097 Query: 3235 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3294 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA Sbjct: 3098 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3157 Query: 3295 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3354 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA Sbjct: 3158 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3217 Query: 3355 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3414 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG Sbjct: 3218 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3277 Query: 3415 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3474 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT Sbjct: 3278 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3337 Query: 3475 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF Sbjct: 3338 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3397 Query: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL Sbjct: 3398 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3457 Query: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT Sbjct: 3458 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3517 Query: 3655 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3714 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG Sbjct: 3518 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3577 Query: 3715 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3774 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL Sbjct: 3578 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3637 Query: 3775 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3834 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL Sbjct: 3638 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3697 Query: 3835 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3894 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL Sbjct: 3698 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3757 Query: 3895 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3954 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH Sbjct: 3758 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3817 Query: 3955 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 4014 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL Sbjct: 3818 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3877 Query: 4015 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 4074 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG Sbjct: 3878 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3937 Query: 4075 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4134 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG Sbjct: 3938 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3997 Query: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE Sbjct: 3998 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4057 Query: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC Sbjct: 4058 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4117 Query: 4255 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4314 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE Sbjct: 4118 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4177 Query: 4315 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4374 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS Sbjct: 4178 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4237 Query: 4375 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4434 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA Sbjct: 4238 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4297 Query: 4435 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4494 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC Sbjct: 4298 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4357 Query: 4495 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4554 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV Sbjct: 4358 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4417 Query: 4555 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4614 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP Sbjct: 4418 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4477 Query: 4615 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4674 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA Sbjct: 4478 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4537 Query: 4675 SLGGPESAVA 4684 SLGGPESAVA Sbjct: 4538 SLGGPESAVA 4547 >gi|41322910 plectin 1 isoform 7 [Homo sapiens] Length = 4515 Score = 8630 bits (22394), Expect = 0.0 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF Sbjct: 6 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 65 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED Sbjct: 66 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 125 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE Sbjct: 126 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 185 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL Sbjct: 186 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 245 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN Sbjct: 246 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 305 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI Sbjct: 306 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 365 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ Sbjct: 366 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 425 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 654 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL Sbjct: 426 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 485 Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS Sbjct: 486 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE Sbjct: 546 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 605 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ Sbjct: 606 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV Sbjct: 666 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ Sbjct: 726 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ Sbjct: 786 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL Sbjct: 846 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE Sbjct: 906 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 965 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS Sbjct: 966 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265 Query: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1325 Query: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385 Query: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445 Query: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505 Query: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565 Query: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1625 Query: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR Sbjct: 1626 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1685 Query: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE Sbjct: 1686 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1745 Query: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805 Query: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865 Query: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925 Query: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985 Query: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2045 Query: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105 Query: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165 Query: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2225 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2285 Query: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE Sbjct: 2286 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345 Query: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2405 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2465 Query: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR Sbjct: 2466 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525 Query: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585 Query: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT Sbjct: 2586 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645 Query: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2874 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG Sbjct: 2646 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2705 Query: 2875 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2934 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI Sbjct: 2706 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2765 Query: 2935 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2994 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN Sbjct: 2766 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2825 Query: 2995 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 3054 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF Sbjct: 2826 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2885 Query: 3055 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3114 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL Sbjct: 2886 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2945 Query: 3115 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3174 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK Sbjct: 2946 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3005 Query: 3175 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3234 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS Sbjct: 3006 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3065 Query: 3235 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3294 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA Sbjct: 3066 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3125 Query: 3295 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3354 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA Sbjct: 3126 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3185 Query: 3355 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3414 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG Sbjct: 3186 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3245 Query: 3415 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3474 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT Sbjct: 3246 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3305 Query: 3475 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF Sbjct: 3306 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3365 Query: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL Sbjct: 3366 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3425 Query: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT Sbjct: 3426 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3485 Query: 3655 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3714 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG Sbjct: 3486 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3545 Query: 3715 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3774 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL Sbjct: 3546 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3605 Query: 3775 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3834 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL Sbjct: 3606 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3665 Query: 3835 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3894 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL Sbjct: 3666 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3725 Query: 3895 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3954 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH Sbjct: 3726 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3785 Query: 3955 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 4014 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL Sbjct: 3786 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3845 Query: 4015 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 4074 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG Sbjct: 3846 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3905 Query: 4075 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4134 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG Sbjct: 3906 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3965 Query: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE Sbjct: 3966 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4025 Query: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC Sbjct: 4026 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4085 Query: 4255 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4314 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE Sbjct: 4086 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4145 Query: 4315 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4374 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS Sbjct: 4146 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4205 Query: 4375 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4434 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA Sbjct: 4206 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4265 Query: 4435 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4494 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC Sbjct: 4266 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4325 Query: 4495 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4554 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV Sbjct: 4326 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4385 Query: 4555 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4614 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP Sbjct: 4386 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4445 Query: 4615 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4674 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA Sbjct: 4446 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4505 Query: 4675 SLGGPESAVA 4684 SLGGPESAVA Sbjct: 4506 SLGGPESAVA 4515 >gi|41322908 plectin 1 isoform 3 [Homo sapiens] Length = 4525 Score = 8630 bits (22394), Expect = 0.0 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF Sbjct: 16 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 75 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED Sbjct: 76 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 135 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE Sbjct: 136 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 195 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL Sbjct: 196 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 255 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN Sbjct: 256 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI Sbjct: 316 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 375 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ Sbjct: 376 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 654 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL Sbjct: 436 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 495 Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS Sbjct: 496 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE Sbjct: 556 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ Sbjct: 616 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV Sbjct: 676 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ Sbjct: 736 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ Sbjct: 796 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL Sbjct: 856 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE Sbjct: 916 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS Sbjct: 976 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA Sbjct: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW Sbjct: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP Sbjct: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA Sbjct: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275 Query: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE Sbjct: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335 Query: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS Sbjct: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395 Query: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA Sbjct: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455 Query: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA Sbjct: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515 Query: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ Sbjct: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575 Query: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL Sbjct: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1635 Query: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR Sbjct: 1636 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1695 Query: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE Sbjct: 1696 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1755 Query: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE Sbjct: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815 Query: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ Sbjct: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875 Query: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED Sbjct: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935 Query: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK Sbjct: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995 Query: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD Sbjct: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055 Query: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK Sbjct: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115 Query: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE Sbjct: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175 Query: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR Sbjct: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2235 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ Sbjct: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295 Query: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE Sbjct: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355 Query: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ Sbjct: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS Sbjct: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475 Query: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR Sbjct: 2476 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535 Query: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA Sbjct: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595 Query: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT Sbjct: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655 Query: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2874 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG Sbjct: 2656 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2715 Query: 2875 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2934 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI Sbjct: 2716 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2775 Query: 2935 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2994 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN Sbjct: 2776 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2835 Query: 2995 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 3054 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF Sbjct: 2836 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2895 Query: 3055 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3114 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL Sbjct: 2896 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2955 Query: 3115 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3174 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK Sbjct: 2956 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3015 Query: 3175 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3234 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS Sbjct: 3016 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3075 Query: 3235 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3294 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA Sbjct: 3076 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3135 Query: 3295 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3354 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA Sbjct: 3136 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3195 Query: 3355 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3414 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG Sbjct: 3196 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3255 Query: 3415 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3474 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT Sbjct: 3256 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3315 Query: 3475 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF Sbjct: 3316 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3375 Query: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL Sbjct: 3376 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3435 Query: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT Sbjct: 3436 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3495 Query: 3655 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3714 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG Sbjct: 3496 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3555 Query: 3715 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3774 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL Sbjct: 3556 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3615 Query: 3775 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3834 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL Sbjct: 3616 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3675 Query: 3835 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3894 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL Sbjct: 3676 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3735 Query: 3895 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3954 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH Sbjct: 3736 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3795 Query: 3955 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 4014 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL Sbjct: 3796 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3855 Query: 4015 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 4074 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG Sbjct: 3856 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3915 Query: 4075 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4134 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG Sbjct: 3916 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3975 Query: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE Sbjct: 3976 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4035 Query: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC Sbjct: 4036 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4095 Query: 4255 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4314 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE Sbjct: 4096 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4155 Query: 4315 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4374 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS Sbjct: 4156 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4215 Query: 4375 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4434 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA Sbjct: 4216 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4275 Query: 4435 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4494 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC Sbjct: 4276 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4335 Query: 4495 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4554 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV Sbjct: 4336 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4395 Query: 4555 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4614 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP Sbjct: 4396 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4455 Query: 4615 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4674 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA Sbjct: 4456 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4515 Query: 4675 SLGGPESAVA 4684 SLGGPESAVA Sbjct: 4516 SLGGPESAVA 4525 >gi|41322912 plectin 1 isoform 2 [Homo sapiens] Length = 4533 Score = 8630 bits (22394), Expect = 0.0 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF Sbjct: 24 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 83 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED Sbjct: 84 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 143 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE Sbjct: 144 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 203 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL Sbjct: 204 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 263 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN Sbjct: 264 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 323 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI Sbjct: 324 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 383 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ Sbjct: 384 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 443 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 654 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL Sbjct: 444 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 503 Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS Sbjct: 504 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 563 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE Sbjct: 564 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 623 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ Sbjct: 624 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 683 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV Sbjct: 684 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 743 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ Sbjct: 744 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 803 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ Sbjct: 804 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 863 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL Sbjct: 864 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 923 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE Sbjct: 924 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 983 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS Sbjct: 984 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1043 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA Sbjct: 1044 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1103 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW Sbjct: 1104 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1163 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP Sbjct: 1164 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1223 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA Sbjct: 1224 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1283 Query: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE Sbjct: 1284 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1343 Query: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS Sbjct: 1344 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1403 Query: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA Sbjct: 1404 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1463 Query: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA Sbjct: 1464 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1523 Query: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ Sbjct: 1524 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1583 Query: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL Sbjct: 1584 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1643 Query: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR Sbjct: 1644 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1703 Query: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE Sbjct: 1704 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1763 Query: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE Sbjct: 1764 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1823 Query: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ Sbjct: 1824 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1883 Query: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED Sbjct: 1884 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1943 Query: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK Sbjct: 1944 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2003 Query: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD Sbjct: 2004 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2063 Query: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK Sbjct: 2064 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2123 Query: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE Sbjct: 2124 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2183 Query: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR Sbjct: 2184 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2243 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ Sbjct: 2244 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2303 Query: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE Sbjct: 2304 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2363 Query: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ Sbjct: 2364 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2423 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS Sbjct: 2424 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2483 Query: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR Sbjct: 2484 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2543 Query: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA Sbjct: 2544 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2603 Query: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT Sbjct: 2604 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2663 Query: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2874 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG Sbjct: 2664 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2723 Query: 2875 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2934 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI Sbjct: 2724 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2783 Query: 2935 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2994 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN Sbjct: 2784 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2843 Query: 2995 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 3054 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF Sbjct: 2844 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2903 Query: 3055 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3114 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL Sbjct: 2904 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2963 Query: 3115 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3174 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK Sbjct: 2964 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3023 Query: 3175 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3234 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS Sbjct: 3024 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3083 Query: 3235 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3294 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA Sbjct: 3084 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3143 Query: 3295 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3354 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA Sbjct: 3144 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3203 Query: 3355 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3414 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG Sbjct: 3204 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3263 Query: 3415 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3474 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT Sbjct: 3264 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3323 Query: 3475 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF Sbjct: 3324 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3383 Query: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL Sbjct: 3384 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3443 Query: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT Sbjct: 3444 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3503 Query: 3655 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3714 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG Sbjct: 3504 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3563 Query: 3715 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3774 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL Sbjct: 3564 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3623 Query: 3775 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3834 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL Sbjct: 3624 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3683 Query: 3835 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3894 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL Sbjct: 3684 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3743 Query: 3895 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3954 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH Sbjct: 3744 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3803 Query: 3955 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 4014 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL Sbjct: 3804 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3863 Query: 4015 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 4074 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG Sbjct: 3864 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3923 Query: 4075 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4134 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG Sbjct: 3924 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3983 Query: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE Sbjct: 3984 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4043 Query: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC Sbjct: 4044 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4103 Query: 4255 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4314 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE Sbjct: 4104 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4163 Query: 4315 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4374 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS Sbjct: 4164 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4223 Query: 4375 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4434 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA Sbjct: 4224 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4283 Query: 4435 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4494 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC Sbjct: 4284 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4343 Query: 4495 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4554 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV Sbjct: 4344 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4403 Query: 4555 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4614 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP Sbjct: 4404 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4463 Query: 4615 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4674 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA Sbjct: 4464 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4523 Query: 4675 SLGGPESAVA 4684 SLGGPESAVA Sbjct: 4524 SLGGPESAVA 4533 >gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens] Length = 1369 Score = 2703 bits (7006), Expect = 0.0 Identities = 1360/1369 (99%), Positives = 1365/1369 (99%) Query: 5 MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET 64 MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET Sbjct: 1 MLMPRDQLRAIYEVLFREGVMVAKKDRRPRSLHPHVPGVTNLQVMRAMASLRARGLVRET 60 Query: 65 FAWCHFYWYLTNEGIAHLRQYLHLPPEIVPASLQRVRRPVAMVMPARRTPHVQAVQGPLG 124 FAWCHF+WYLTNEGIAHLRQYLHLPPEIV ASLQRVRRPVAMVMPARRTPHVQAVQGPLG Sbjct: 61 FAWCHFFWYLTNEGIAHLRQYLHLPPEIVAASLQRVRRPVAMVMPARRTPHVQAVQGPLG 120 Query: 125 SPPKRGPLPTEEQRVYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT 184 SPPKRGPLPTEEQR+YRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT Sbjct: 121 SPPKRGPLPTEEQRLYRRKELEEVSPETPVVPATTQRTLARPGPEPAPATDERDRVQKKT 180 Query: 185 FTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL 244 TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL Sbjct: 181 STKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIAL 240 Query: 245 DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW 304 DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW Sbjct: 241 DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDMTAKEKLLLW 300 Query: 305 SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE 364 SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE Sbjct: 301 SQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLENLDQAFSVAE 360 Query: 365 RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL 424 RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL Sbjct: 361 RDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANELQLRWQEYREL 420 Query: 425 VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE 484 VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE Sbjct: 421 VLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLE 480 Query: 485 GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL 544 GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL Sbjct: 481 GAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGL 540 Query: 545 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 604 CEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG Sbjct: 541 CEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 600 Query: 605 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 664 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD Sbjct: 601 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQD 660 Query: 665 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATR 724 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARSDEGQLSPATR Sbjct: 661 LLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARSDEGQLSPATR 720 Query: 725 GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR 784 GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR Sbjct: 721 GAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDR 780 Query: 785 NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 844 NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM Sbjct: 781 NTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWM 840 Query: 845 LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDA 904 LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATVTRLEDLLQDA Sbjct: 841 LQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDA 900 Query: 905 QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE 964 QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE Sbjct: 901 QDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE 960 Query: 965 CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLH 1024 CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQALVTLWHQLH Sbjct: 961 CQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLH 1020 Query: 1025 VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG 1084 VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG Sbjct: 1021 VDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFG 1080 Query: 1085 PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1144 PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL Sbjct: 1081 PEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRL 1140 Query: 1145 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1204 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL Sbjct: 1141 RLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1200 Query: 1205 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA Sbjct: 1201 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1260 Query: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER Sbjct: 1261 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1320 Query: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM Sbjct: 1321 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369 Score = 69.7 bits (169), Expect = 6e-11 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%) Query: 1659 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1710 ++E A+EK QR ++ + LR + + RL A + R + + + + R Sbjct: 287 QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346 Query: 1711 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1770 E + S AE+ + R L E V V Q E++ R ++ Sbjct: 347 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403 Query: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1822 ++ANE L+LR Q ++ L + + A E R EE + + Sbjct: 404 -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458 Query: 1823 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876 + EL +E +K R Q EG Q +L L E E G+ +LE E Sbjct: 459 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514 Query: 1877 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1936 + R+E E ++ +L+ EAG E Sbjct: 515 ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544 Query: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1996 +A L L + R LA ++ E ER L K ++ I L Sbjct: 545 LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587 Query: 1997 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 2046 + + + R + E RR RL E+ + + RL Q+ + + ++R+ Sbjct: 588 DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647 Query: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 2104 L + TLR + + + + + A G +E +LG R + + QA++ Sbjct: 648 PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705 Query: 2105 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2161 E AR + QL+ R+ R+ A +++ R +LE + + A +E L Sbjct: 706 ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765 Query: 2162 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2220 E+ E+E + + + + K +++ +E EL++ +++ Q+ D+L E Sbjct: 766 NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819 Query: 2221 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2263 AR E + EA ++ Q V EAE Q +E + Sbjct: 820 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879 Query: 2264 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2323 + +A R E + + AQ E+ L + + + + K K Q L+ + Sbjct: 880 RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935 Query: 2324 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2374 L L Q+E T H+ + L Q + ++ + V F V Sbjct: 936 MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995 Query: 2375 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2431 +E+ + R+EA+++AL+ + Q + +A ++ R V + A R Sbjct: 996 QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048 Query: 2432 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2475 L E+ Q E + ++ Q+A RL AE E LLQ ++ Sbjct: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108 Query: 2476 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2529 AQE++R Q+ E + + LEA R +L + E A R+AE Sbjct: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159 Query: 2530 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2586 +AQA E + R +AE++ LA E TL Sbjct: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197 Query: 2587 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2645 +ELE KL+Q L + E+++T+ +++ TQ ++ + ++ L + + Sbjct: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252 Query: 2646 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2695 +E KA L++L A+AQQ LR+E + Q+ E+ +QR E R Sbjct: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310 Query: 2696 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2723 + + + R Q L Q + ++R+ E+L Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338 Score = 67.0 bits (162), Expect = 4e-10 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%) Query: 1664 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1717 AA E++R + EE+ L+ +E E ++A+ R++ + +LE A ++ + ++ Sbjct: 433 AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492 Query: 1718 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777 +E+ + HVA+ ER Q ++E ER L+ + Sbjct: 493 -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528 Query: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1833 + +LQ E ++ L QA+A Q + A + +R G+ E + + Sbjct: 529 RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588 Query: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893 + L +G Q + + RL E+ + E RL+ AA + ++ + Sbjct: 589 VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642 Query: 1894 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1941 + R E+E S R ++ + E+++ R+ EA+ G R L + Sbjct: 643 SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699 Query: 1942 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 2000 +A E A+ QL+ R R+ + +L ++ L+ E+ + Sbjct: 700 EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752 Query: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060 + ++ + + EE+ +D + +K S S L R+ L E +++ + Sbjct: 753 SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811 Query: 2061 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 2108 + +L SF+ A + L+L ++ NA + E E Sbjct: 812 GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871 Query: 2109 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2165 Q+ +E RR+ + +R E+ + A+ K L E + L + A+ + + Sbjct: 872 QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928 Query: 2166 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223 + A ++ L A Q E H K E Q + S L A Sbjct: 929 PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982 Query: 2224 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2267 + +E +EA R++A+ +A + + V+ L QS Q R+ Sbjct: 983 AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042 Query: 2268 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2312 + A L+ E +++A + QA LR Q A + + AE Sbjct: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102 Query: 2313 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2364 Q+L Q AQ E EL +RLQLE + + + RL+ E AR+ +Q Sbjct: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156 Query: 2365 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2423 E + ++E L K AR+ AE + L L + L+ E E E+ LS Sbjct: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216 Query: 2424 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2483 E + L + + AE++L+ + ++EA + A L+ K + ++ R Sbjct: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271 Query: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2541 E ++ L +E +G Q E +QR E E ER + RVA+ + R QA A+ D + Sbjct: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331 Query: 2542 RFRKQAEEIGEKL 2554 +++ E++G +L Sbjct: 1332 --QRELEQLGRQL 1342 Score = 62.0 bits (149), Expect = 1e-08 Identities = 164/754 (21%), Positives = 286/754 (37%), Gaps = 154/754 (20%) Query: 1328 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1387 V Q+ R+ ELE LRY ++ L AW+++ + R + + D +V QL Sbjct: 639 VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690 Query: 1388 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1435 + L + IE K+E + Q A + Y L + KA+L + S Sbjct: 691 HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750 Query: 1436 PAKKPKVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQ 1490 V + ++ ++ +E ++ +S+ T + + S +R +E +E+++ E Sbjct: 751 --LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKEL 808 Query: 1491 QRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------QAE 1524 Q A +R + +AAL+ Q QL EAH + A +AE Sbjct: 809 QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 868 Query: 1525 REAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAK 1573 + ++LQ+ ++ + V R E+ DAQ +K + E L L + ++A +Q K Sbjct: 869 GQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928 Query: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK-- 1626 R R RL + ++++ + G Q L + EA Sbjct: 929 PRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVC 988 Query: 1627 -------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679 ++ QE RL Q Q Q V++ S + A + +R +Q + Sbjct: 989 FLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----AWQSLRRDVQLIRSWS 1043 Query: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1739 L R + E RQ +LE ++ + Q E ER Sbjct: 1044 LAT------FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1097 Query: 1740 VAQLREEAERRAQQQAEAERAREEAER---ELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796 QL + E+ AQ+++ +R E + +LE + + LRL L E + AQ Sbjct: 1098 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA---RECAQ 1154 Query: 1797 AEAEKQKEEAEREARRRG----KAEEQAV--------------RQRELAEQELEKQRQLA 1838 AE+QK +AE E +G AE + V + EL +LE+ R L+ Sbjct: 1155 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1214 Query: 1839 --------------EGT--AQQRLAAEQE---------------------LIRLRAETEQ 1861 GT A++ L A +E L +LRA+ E Sbjct: 1215 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1274 Query: 1862 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1921 + L +EL Q Q+ E + E+ + R + LL + + ++ Sbjct: 1275 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDV 1330 Query: 1922 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1955 ++ LE + R E A L A ++A+R+++ Sbjct: 1331 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1364 Score = 60.8 bits (146), Expect = 3e-08 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%) Query: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1227 GL + + A+ E+ A + +P R LG+L+ ++ + S L L++ Sbjct: 693 GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750 Query: 1228 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1286 + S V T+ + EE++ + T + A K S L + E ++ Sbjct: 751 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803 Query: 1287 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1346 +++ Q G+RL + VE ++ A L +W +L + L++ Sbjct: 804 --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858 Query: 1347 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1396 +++ + + G LQ+A RR+ L D+Q +EQL + + L + Sbjct: 859 QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918 Query: 1397 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1444 + + V + + + + A+ DY ++++ +K + PA+ K S Sbjct: 919 KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978 Query: 1445 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1499 GSE+ + L + +T L +Q+ ++ + + + L Q +L Sbjct: 979 GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038 Query: 1500 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1559 + + E QA E + + Q+ E + A+++ S Sbjct: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098 Query: 1560 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1619 QQL QS E Q ++R R E++ +RLQLEA E + + LR Sbjct: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144 Query: 1620 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1675 + K A+E A+R+ Q +K QAEVE + A A EK AL A Sbjct: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193 Query: 1676 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1735 LR + E +L Q ++S A + EK + ++ Sbjct: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230 Query: 1736 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1794 A LR E+ + QA E L+A +A +L+A+ AQQ + Sbjct: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280 Query: 1795 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1852 + E +E ER +R G+ + + R RE Q LE+ Q LA+ +QR Sbjct: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333 Query: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1892 E EQ +Q + E L A +++++++A Sbjct: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368 >gi|33188445 microfilament and actin filament cross-linker protein isoform a [Homo sapiens] Length = 5430 Score = 1378 bits (3566), Expect = 0.0 Identities = 922/2789 (33%), Positives = 1482/2789 (53%), Gaps = 246/2789 (8%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEVLSG LPREKGRMRF Sbjct: 74 DERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRF 133 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 H+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI +SG+S D Sbjct: 134 HRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGD 193 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 M+AKEKLLLW+Q++ GY G++C NF+S W DG++FNA+IHR++P L+DM +V Q+N E Sbjct: 194 MSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRE 253 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA P+VP+ +G+ A E+ Sbjct: 254 NLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEV 312 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 RWQEY+ V L+ W++ HT ++ FP + E++ L++Q++ FKE E+ AKE +K Sbjct: 313 DSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKG 372 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 R + +Y+ LE ++ G++K+P GYHP DVE+EWGKL + +LEREK LR ERLE L +I Sbjct: 373 RIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQI 432 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 K+Q A CEE+L A LQ+D L +G+ Q +V + + + +IR L D+Q Sbjct: 433 ANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQ 492 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------------------VAAP 636 L+D + Q E++ RV RL + LV +R E + G A P Sbjct: 493 ILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEP 552 Query: 637 ATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 685 T+ + S R+P EL ++ LR++ +LL+WVEE Q +++ AEWG DL Sbjct: 553 LTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDL 612 Query: 686 PSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSS 745 PSVE QL + + +H S+EE + ++ AR EG++S +Y + LG+L+ QY KL +S Sbjct: 613 PSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETS 672 Query: 746 KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELK 805 R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++AK+ +S L ELE K Sbjct: 673 SFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEK 732 Query: 806 EKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFF 865 + + LQ+ + L E+HPA+ TVE++ AA+Q+Q WM QLC C+E H+KEN AYFQFF Sbjct: 733 QDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFF 792 Query: 866 SDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 925 SD RE E L+ LQ++++RKYSCD + +++RLEDLLQD+ DEKEQL + K ++ L R+ Sbjct: 793 SDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRS 852 Query: 926 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 985 K +VQLKPR P H ++ + + AVCDY+Q+E+T+ K DEC L +Q + WKV+S +G+E Sbjct: 853 KTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNE 912 Query: 986 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1045 A VPSVCFL+PPPN++A E +R+E +Q ++ LWHQLHV+ KSL++W LR+D+ L+++ Sbjct: 913 AMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQT 972 Query: 1046 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQL 1105 W+L R+ P E Q + +L+ HY+ FL+DS+D+ F DRL E E +C +Q L Sbjct: 973 WNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHL 1032 Query: 1106 LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----LPLDKEPARECAQRIA 1161 ++S+E +EE+ + ISELK+IRL+LE E R V R++ D++ ++ A RIA Sbjct: 1033 MKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIA 1092 Query: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1221 EQ+ Q +++ L + +S + + L S + PTLRSEL L + K++ V LS +Y Sbjct: 1093 EQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVY 1152 Query: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281 L KLKT+ +++R Q AE +++ +E +L + + V A L LEA ++L+ + + + Sbjct: 1153 LNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNS 1212 Query: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341 F L +E+ A+ V E++ + ER++++ER++E+ +QL ERW V+AQ ++RQ ELE Sbjct: 1213 VFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELES 1272 Query: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEK 1401 + L YR L W+++ +QE ++ DS+ + EQL Q+ AL EIER+ K Sbjct: 1273 IQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTK 1332 Query: 1402 VEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAKKPKVQSGSESVIQEYVDLRTHY 1460 +++CQ+F++QY +KDYELQL+TYKA +E SP K+ ++ S S+++ QE++DLRT Y Sbjct: 1333 LDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRY 1392 Query: 1461 SELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV---EAALEKQRQLAEAHA 1517 + L TLT+Q++K+IS+ LRR+EEEE++ E+++ E E++ E+ + L + Q + Sbjct: 1393 TALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSS 1452 Query: 1518 QAKAQAEREAKELQQR-MQEEVVRREEAAVDA----------------QQQKRSIQEELQ 1560 + K + E L+Q+ + EE+ ++E +A +++K+ I E+L Sbjct: 1453 ETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLN 1512 Query: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620 L ++ A Q + + S+L + E + ++ Q +Q +L + +AE Sbjct: 1513 ALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL----EDLCSWVGQAE 1567 Query: 1621 EAEA--QKRQAQEEAERLR------RQVQDESQRKRQAEVELASRVKAEAEAAREK--QR 1670 A A Q R Q++ L+ + +QD+ Q + + + ++ E + K R Sbjct: 1568 RALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPR 1627 Query: 1671 ALQALEELRLQAEE------AERRLRQAEVERARQVQVALETAQRSAEAELQSKR----- 1719 L AL E QA+E E R+ Q E+E A + ET + A EL + Sbjct: 1628 ELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDA 1687 Query: 1720 -----ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1773 S QL +L E ++ A L + A +A E+ +++ E + Sbjct: 1688 LLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKA 1747 Query: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1833 + E L Q + AQA ++ EEQ + Q++L E + + Sbjct: 1748 RHQELLS---QQQNFILATQSAQAFLDQHGHNL--------TPEEQQMLQQKLGELKEQY 1796 Query: 1834 QRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEELARLQR-----EAAAATQK 1886 LA+ A+ Q + EL + + ++ E + E+EL + + E + K Sbjct: 1797 STSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLK 1856 Query: 1887 RQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFREL 1936 RQ ++ + ++ + S + + S E K +L+ R+ L Sbjct: 1857 RQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTAL 1916 Query: 1937 AEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ERVLAEKLAA----IGEATRL 1985 + RL + L + + Q A Q EA E++L++ +A+ + E Sbjct: 1917 HSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLAT 1976 Query: 1986 KTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER----LAQLRKASDS 2041 + + L E + E+L+++A D +E + A ++E L+ + S S Sbjct: 1977 TKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAPDHRHVQETTDSILSHFQSLSYS 2032 Query: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKAELELELGRIRSNAEDTLR- 2097 ER L++ + Q + V+E + +L S E+ GK L G I+ ++ Sbjct: 2033 LAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKL 2091 Query: 2098 ----SKEQAELEAARQ----------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143 +++++ LEA R+ AA + + E +R ++ ++E K Sbjct: 2092 KQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKK 2151 Query: 2144 ALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQ 2203 L + E + + ++ E + A Q Q+ Q +E QQ+ + Sbjct: 2152 LLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTL 2211 Query: 2204 QTLQQEQSV------LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQS 2257 + L E S L Q + + R+ E ++ + E++A+ + Q++E +L ++ Sbjct: 2212 EHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRT 2271 Query: 2258 AE-------------EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2304 + E + + + + E L+ + A++ E+ + + M Sbjct: 2272 FQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIM 2331 Query: 2305 EKHKKFAE--------------------QTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344 E ++ T + +++ +++ + L+ E+ + E Sbjct: 2332 EITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQE 2391 Query: 2345 ELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQ 2404 LQ + E ++ + V + L S ++ + + + + E L+ Sbjct: 2392 SLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE 2451 Query: 2405 EEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461 + + K+++V E A L V +QEA +++ EE ++ E + + Q + A+ Sbjct: 2452 QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASH 2511 Query: 2462 L----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEM 2515 L AE++L +KEL L D + Q ++ Q + EA RQ+ ++ Sbjct: 2512 LACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQFMLKEFEARRQQHEQL 2570 Query: 2516 SAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTELATQ------------ 2562 + A+ + ++S + ++ +++ Q ++ E+ +KL+ R+ Q Sbjct: 2571 NEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQIDQAIVKSTQYQELL 2630 Query: 2563 ----EKVTLV-QTLEIQRQQSDHD--AERLREAIAELEREKEKLQQEAKLLQLKSEEMQT 2615 EKV V Q L +Q S ++ E +E+ + E+L E K Q +E+ Sbjct: 2631 QDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSV 2690 Query: 2616 VQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQ 2675 + EQ L KD L +R + LE L D + + Q Q+ Q Sbjct: 2691 LIGEQYL-------------KDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQ 2737 Query: 2676 QQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730 Q ++ R L + + + E + ++ EE Q+ Q E++ E + Sbjct: 2738 QMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGES 2797 Query: 2731 L------REQLQLLEEQHRAALAHSEEVT 2753 L E+ + L+ Q H EE++ Sbjct: 2798 LLLSVPPGEEKRTLQNQLVELKNHWEELS 2826 Score = 131 bits (329), Expect = 2e-29 Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%) Query: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1210 E R QR++ Q + E + + + S + L A TL EL + +G+ Sbjct: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694 Query: 1211 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269 + L ++L+T++L ++G + A + + + L Q EL Sbjct: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750 Query: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1313 + +A+ + L+ +L+ +E + L Q G +V E Sbjct: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810 Query: 1314 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1373 + ++ +L W+ + +T RQ L+ ++ + Y+ + L W++D + + +++ Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869 Query: 1374 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1432 D + L + +A+L E+E+ +E A IN+ + E + KA + + Sbjct: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928 Query: 1433 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1490 + + ++ + ++GS E + Q + + + + K + ++E + L Q Sbjct: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981 Query: 1491 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1530 + E+ EV ALE Q Q + A++E E+ Sbjct: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041 Query: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1589 +QR+ V E Q ++E QL + E+ + + +IE+ Sbjct: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100 Query: 1590 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1632 +I V++L +EA+E + G G + EL+AL + + + + QE+ Sbjct: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160 Query: 1633 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1685 E +V+D ++ + + +AEA E + Q L + ++ Q + Sbjct: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220 Query: 1686 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1740 + +L+Q +Q A ++ + E E+ ++ + +K AQ LQE + Sbjct: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279 Query: 1741 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1795 + ++ E A+ E + AE ++ + Q++ + L+ L + + Sbjct: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337 Query: 1796 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1851 QAE + + AE R + G+ E R EL + +Q+QL + A+Q + Sbjct: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397 Query: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911 + + TE+ + + + A++Q++ +++E V +++ ++ + Sbjct: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454 Query: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1971 S + +++++ R+ E+ + R AL ++A +L ED Sbjct: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503 Query: 1972 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 2031 E E+ E E++ +D F++ L Q A H A + E Sbjct: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544 Query: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091 + +K D ++ + L++ T EE+L ++ + A++ + Sbjct: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591 Query: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 2151 + LR+ EQA A + + E RE EE + S + Q + + L Sbjct: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650 Query: 2152 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2200 K +V E R + + + S L+L A+E K + + + V + + Sbjct: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710 Query: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2255 +Q++ Q EQ+ +L AE R+ ++ E++ ++ QV++A R K Sbjct: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767 Query: 2256 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2315 S +E R++ + +K QE ++ ++Q +A + +++A Sbjct: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816 Query: 2316 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2375 ++AQV L Q ET + + EE + L A+ A Q+ ++ +R E Sbjct: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870 Query: 2376 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2434 +++ K I+ +L+ + EE E +++ ++A + +E R R LA Sbjct: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925 Query: 2435 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2482 +E ++Q + E + + E ++ + R + AE + +++ + A + + Sbjct: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985 Query: 2483 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2530 LQ E ++ ++L +QG + L A E Q +L ++ A AE +++ ++ Sbjct: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045 Query: 2531 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2584 + D ++ + +H E +++V +T++ + + E Sbjct: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105 Query: 2585 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2639 +R A+L E EK ++++ + E + +E+ L++ + Q+ + +D+L Sbjct: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164 Query: 2640 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690 +++ KL + +D++ + ++ + E +QQ +ME+ + ++ Sbjct: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224 Query: 2691 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2744 +A E + + R E L +L+ E +A +L Q Q E+ + Sbjct: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279 Query: 2745 ALAHSEEVTASQ 2756 L H+EE+ +Q Sbjct: 4280 WLTHTEELLDAQ 4291 Score = 129 bits (325), Expect = 5e-29 Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%) Query: 343 DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 402 D N V+ + E + +A VAE+ ++RL ++D+ + EK S L + RV Sbjct: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259 Query: 403 PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 459 Q +R +EL+ + +YR L++W+ TA +E P E+ +L Q Sbjct: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317 Query: 460 KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 500 + + E+ + ++ + Q V+ +L++ PG Sbjct: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377 Query: 501 --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 551 +D+ + L + K + RLE +++V + + E +E L Sbjct: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437 Query: 552 ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 598 L ++ GK + D++KA ++L ++ T K+ Sbjct: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492 Query: 599 GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 656 +H G ++ + + + E+L A+ Y+ L G A Q+ +Q+ Q+ Q+ + + Sbjct: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549 Query: 657 STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 712 +T + L+DL +WV + + + G + DL +++ + L I+ Sbjct: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609 Query: 713 RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 759 D + +LSP A R+ L + QY L ++ + LE + Sbjct: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669 Query: 760 --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 810 + A KEL +K + VG TN+ ++ A + + L Sbjct: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729 Query: 811 ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 870 + A ++L D Q L Q +++L A A Q ++ Sbjct: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779 Query: 871 AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 927 E Q+ QKL E L+ +YS + + L+ + Q QDE ++ L ++K S L + K Sbjct: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836 Query: 928 VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 984 +L+ H LP LL +V HKGD + Q KVL S Sbjct: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890 Query: 985 EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 1035 E PS + LV ++A E T RL + L+ +HQ SL AW Q+ Sbjct: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950 Query: 1036 LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 1086 +V+ + S ++A+ T K ++ A H + + Q RD + G Sbjct: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010 Query: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 1146 D + S H+Q L SL A+ S Q+ I++ + ++ LE+ +++ + Sbjct: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066 Query: 1147 PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1200 L+ + + + Q+A A L + +AR L A E V E S A L Sbjct: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124 Query: 1201 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1258 + +L + EQ L EK ++ ++ + E + ++ ++ + A+ Sbjct: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181 Query: 1259 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316 P+ + T +++L + E QQ D L + G L ++ + ++ Sbjct: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232 Query: 1317 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1376 RV L + + + R+++ QL +R+ WL++ + A Sbjct: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292 Query: 1377 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1436 + + +Q+ ++LL++ G VEE N I + +T S Sbjct: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345 Query: 1437 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1496 GS + DL +++ + +Y K R E + + + + Sbjct: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405 Query: 1497 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1556 E + ++ K+ L A + K + + + E+ + Q+ K ++ Sbjct: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465 Query: 1557 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1616 L S EAE K ++ EL + Sbjct: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491 Query: 1617 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1674 RA E A++RQ +E A L ESQ R E EL V A + Sbjct: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551 Query: 1675 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1729 + L+ EA R+ + E A+ + V+L T+Q + ELQS + E T +L Sbjct: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609 Query: 1730 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1781 RS Q + V L++ +E+ RA Q + ++ + E + QL+ +R Sbjct: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669 Query: 1782 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1839 L+ EV + ++L + E+ ++ ++ + E A+ + L + ++ +L Sbjct: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728 Query: 1840 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1897 A Q+ + +R + +Q +Q + + +L RLQ + Q+ +E + L + Sbjct: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784 Query: 1898 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1954 EV++A E ES S + K+ L+ + + EE ++ + A RQ Sbjct: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834 Query: 1955 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 2013 +L + Q+A+ + E L E + K +E + L + E+ LR A + Sbjct: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891 Query: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 2073 +RR + ADI L +A + + +K + + V EE+ A S E+ Sbjct: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945 Query: 2074 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133 E + I E +K Q E+ A Q + + + A++ V ++L Sbjct: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002 Query: 2134 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2193 + + R L E +A +L +AE L++ Q + E K Sbjct: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058 Query: 2194 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2253 + Q +++ Q + D+L G R + ++ QS Q+E+ Sbjct: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102 Query: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2312 KL EA + R E+ L E+E +K+ + Sbjct: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149 Query: 2313 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2371 T R KA+ EQ ELT R++ D + L AE EA + E E+ + + Sbjct: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205 Query: 2372 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2413 + Q E++ L+ +++ N + LI KD + L+ + E++ K+V Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265 Query: 2414 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2473 A+ A+L A + + A E L A E+++ + E +KA+ +Q+QK Sbjct: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321 Query: 2474 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2532 L +RL +D++ L + +G + AE + +++ + E L+ R E+ S+A Sbjct: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374 Query: 2533 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2584 AR + ED A++F + AE I + L TE LA E V QT +IQ+Q H A Sbjct: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431 Query: 2585 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2643 L E ++E + Q K+ Q L T +Q LSEK DSL R Sbjct: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476 Query: 2644 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703 I+ + L ++ A+ E++ Sbjct: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505 Query: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2763 E L L + + + ++ ++ +L QH LA +EE+ + + + Sbjct: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556 Query: 2764 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811 NG+ L E + DG++ R + + S++ L+ L Q Sbjct: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601 Score = 100 bits (249), Expect = 3e-20 Identities = 316/1613 (19%), Positives = 616/1613 (38%), Gaps = 239/1613 (14%) Query: 1163 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1218 Q K Q +V GLG+G+ + + + V L E + TL ++ + +L++ Sbjct: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279 Query: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278 + + L+ + + T EE++ + E + V A + E K L+ + Sbjct: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329 Query: 1279 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1334 ++ T D L+ E G R+ Q D RE++ LE RW +L++ Sbjct: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376 Query: 1335 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1394 RQ++LE + + + E+A+P+ +L ++ + + + +++Q+ + +AL E+ Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435 Query: 1395 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1444 IE H V + + A+Q + + K LQ + Q A + S Sbjct: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495 Query: 1445 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503 + ++ V++ +E+ L+S ++K + + + + LA + R++ + + Sbjct: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554 Query: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1557 A Q L + + + + ++ R + V +A +Q + +S E Sbjct: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614 Query: 1558 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1611 EL + E E+ Q+ E + + +++E+ RL L+ T + A E Sbjct: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673 Query: 1612 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665 L RAR +A Q + + + ++ QR +Q E AE Sbjct: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729 Query: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1722 E +R L AL +RL E ++ Q +V++A + + + + EL S R+ Sbjct: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783 Query: 1723 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1777 +KT E+ SL +++ A++ L E R ++ E EL W ++ Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842 Query: 1778 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1829 AL +L + + ++ Q E +Q E+ E + + +E + E+ E+ Sbjct: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902 Query: 1830 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1880 + +K Q+ E Q+ LA ++ + + TE ++ +LE E L+ R+ Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962 Query: 1881 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1935 A K +E ++ E+E L S K R EE RS + + + Sbjct: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022 Query: 1936 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1985 + ++A AEE + + +LAE+ A + + + L + G + + + Sbjct: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082 Query: 1986 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 2038 K + E A KE E E +R L D F E+ + D + L K Sbjct: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142 Query: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098 LE+ +ED ++ Q ++ + A+ + + +G + +D L Sbjct: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197 Query: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158 ++ ++E +Q+ E E+ + E ++K A +E + L E++ L + E Sbjct: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251 Query: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218 ++ R + L L Q Q +EL L + +LD R Sbjct: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293 Query: 2219 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2270 E E A+ + + QA E E L+ SA + A + Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349 Query: 2271 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2330 A + + Q+ R Q Q+ L+Q Q +E+E ELT + Sbjct: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395 Query: 2331 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2390 QL + L E AR++ EL+ S+LKA+ E N+ Sbjct: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434 Query: 2391 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2450 L DK ++++ + + A L + + + L + LA + Sbjct: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQN 4491 Query: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510 + + T L +Q +A + L Q+ EE + F + A R Sbjct: 4492 SLQEFINWLT-------LAEQSLNIASPPSLILNTVLSQI-----EEHKVFANEVNAHRD 4539 Query: 2511 RQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561 + +E+ +LK + + Q+R E+ QR ++ + + R + Sbjct: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 4599 Query: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2621 + L+ LE DAE ++ E+ + +K++ + L E +T+ +Q Sbjct: 4600 EAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHKEFQKTLGGKQP 4648 Query: 2622 LQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669 + +T +AL++ L +DS + + F+ + + K + + V + +L E Sbjct: 4649 VYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQHKLEE 4700 Score = 67.0 bits (162), Expect = 4e-10 Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%) Query: 1057 EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 1113 EE RQ S+ + H L+ PE+ M E +Y + Y Q+ + + Q A Sbjct: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922 Query: 1114 ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1165 E I+E D I LE E + RLR +P + + REC I++ + Sbjct: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978 Query: 1166 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1221 A E+E L L E+++ + + AA ++ +L+ + E +++ Sbjct: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038 Query: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281 ++ L + L + +L +K+ Q + L + +K+ AE + Sbjct: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094 Query: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341 D L +EL + +G L GE E R+ + ++ W+ + R +LE Sbjct: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152 Query: 1342 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1399 + Y+++ + WL + ++ MP D V++QL + + E+ + Sbjct: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207 Query: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459 Q+ + +N + L+ T + + + P + K + + E + R H Sbjct: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258 Query: 1460 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1517 E L Q+ + E + + E L + QR + ++ EVE LA+ H Sbjct: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310 Query: 1518 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1576 + A + E + E++ E +A D RS E + Q +S + + + +Q Sbjct: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368 Query: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636 ++ + EI L+L E Q + + E A Q E +L Sbjct: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424 Query: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1694 + + + +Q + + L SR + + + E+ AL Q + + EE + +L +A + Sbjct: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483 Query: 1695 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753 A + Q +L E AE AS S EEH A E Q Sbjct: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540 Query: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1812 E ++ + + ++ + + L + +Q+ E Q+S+ E + ++A + A++ Sbjct: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597 Query: 1813 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1872 +A ++ + E AE L+ + +++ + +L + + +T G+Q Sbjct: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655 Query: 1873 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1929 R +E + Q+L+ L +VR + + + + EE+ S + L+A Sbjct: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715 Query: 1930 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1972 ++ + A + + Q++L + Q R E Sbjct: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775 Query: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 2031 + G+ L T + K ++ RL + L + E F R + ++ E+ Sbjct: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833 Query: 2032 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091 L + R A + E + L++ ++VEE+ + + ++ A + + Sbjct: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892 Query: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 2145 +R++ + L A+Q Q E A + + L A + A R ++ Sbjct: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952 Query: 2146 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2205 + ++R+KA + E + E ++ ++ + +K + E HA +++ +++ Sbjct: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009 Query: 2206 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2259 L Q + ++EA + Q A + +R++ +A +RL++ E Sbjct: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064 Score = 39.7 bits (91), Expect = 0.071 Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%) Query: 4616 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4667 S S GS AGSR GSR SR GS FD T S S T SS+ G RR Sbjct: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403 Score = 34.3 bits (77), Expect = 3.0 Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%) Query: 642 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 694 +V +S++R L+D+ R Q L+ W+E+ + +D E D ++ QL Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635 Query: 695 HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 748 H+ G Q + + + RA ++ L P + LG + ++ + S R Sbjct: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694 Query: 749 LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 800 LE F+ A + WL + E E++ D N+ +++ + Sbjct: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751 Query: 801 ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 860 EL + ++ L+ +G L+ V+ L T+W + +L ++ L++ Sbjct: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811 Query: 861 YFQFFSD 867 + F D Sbjct: 4812 QAEVFRD 4818 >gi|207452735 epiplakin 1 [Homo sapiens] Length = 5090 Score = 1268 bits (3280), Expect = 0.0 Identities = 798/1967 (40%), Positives = 1134/1967 (57%), Gaps = 218/1967 (11%) Query: 2774 AAEAEP-EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2832 AAE +P + +F GLR++VSA+ L A ++S + L L+QG TTV E+A + V+ L+G Sbjct: 1511 AAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGG 1570 Query: 2833 SSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVK 2892 + IAG+L++ T E++S+ AL+R +L PGTAL+LLEAQAA+GF++DP NR+LTV EA K Sbjct: 1571 NFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFK 1630 Query: 2893 EGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGV 2952 G+ G E + KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGG+ Sbjct: 1631 AGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGI 1690 Query: 2953 IDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDP 3012 IDPVHSHRVPVDVAYR GYFDEEMNR+LADPSDDTKGFFDPNTHENLTYLQLLERCVEDP Sbjct: 1691 IDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDP 1750 Query: 3013 ETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTA 3072 ETGL LL + KG VY + R V + T G+F + V+ W++++S YFT Sbjct: 1751 ETGLYLLQI---IKKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTE 1807 Query: 3073 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQE-QKGRLCFEGLRSLVPAAELLESRVIDR 3131 +++R+L++++ +EK+++II T +EE E Q + +R V AA+L SRVID+ Sbjct: 1808 DRKRELIQEYGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQ 1867 Query: 3132 ELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMA 3191 + L+ G + ++ ++ V+ L G++ IAGV + + +S++ A +K+L+P+ A Sbjct: 1868 KTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927 Query: 3192 VALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSV 3251 LLEAQA TG ++DP T +L+VDEAV GLV E E+LL AE+A TGYRDP TG ++ Sbjct: 1928 TWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTI 1987 Query: 3252 SLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAP 3311 LFQA++K LI + + LRLL+ Q++TGG++DP HR+PL+ A RGCL ++ +S Sbjct: 1988 PLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQ 2047 Query: 3312 RADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETF 3371 + K + DP+T E +Y ELQ+RCRP + TG L P++ KAAR + + + + R Sbjct: 2048 KHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVN-KAAR---DSEHIDDETRRAL 2103 Query: 3372 EKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT-GKVTVEKVIKILITIVE 3430 E VE+ VG F+G+ T+W L++SEY T E++ +L+R +RT + ++ V ++++ ++E Sbjct: 2104 EAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILELIE 2163 Query: 3431 EVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQG 3490 + ET + L F G+R + ASELL+S +++ + L+ G++T ++L E V+ L+G Sbjct: 2164 KQET-SNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEG 2222 Query: 3491 SGCLAGIYL-----EDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLY 3545 + C+AG+ + +EK+SIY+AM +G+LR TA +LLEAQAATGF++DPVRN RL Sbjct: 2223 TSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLS 2282 Query: 3546 VHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQ 3605 V E V AGVVG E+ E+LLSAE+AVTGY DPY+G ISLFQAMQK L++R+HGIRLLEAQ Sbjct: 2283 VEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQ 2342 Query: 3606 IATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLE 3665 IATGG+IDPVHSHRVPVDVAY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL Sbjct: 2343 IATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLR 2402 Query: 3666 RCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLW 3725 RCV DP+TGL +L L G A EE R A + ++ PG G+ G ++S+W Sbjct: 2403 RCVPDPDTGLYMLQLAGRGSA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVW 2455 Query: 3726 EVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLT 3785 E++ + E++R L++ ++AG +T E + + ++ + + + R Sbjct: 2456 ELLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQ------------AQARAE 2503 Query: 3786 AEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQ 3845 A EA + LR T ++ G + G +P ++ Sbjct: 2504 A----EAGSPRPDPREALRAATMEVK--------------VGRLRGRAVP-------VWD 2538 Query: 3846 ALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER 3903 L G +S AR L A+ +G L P RLT ++EA P+L D Sbjct: 2539 VLASGYVS-RAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDARRGPRE 2597 Query: 3904 ---AVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV 3959 A G D Q + +E A R + L + R F P+ V Sbjct: 2598 PGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSV 2657 Query: 3960 --AYQRGYLNKDTHDQ-----------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDG 4006 YL++ D+ L + V + V T+ERLS Sbjct: 2658 WDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLS------------- 2704 Query: 4007 TGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQK 4064 K++FRGLR+Q++ EL S ++ T L +G +++EVT+ ++++ Sbjct: 2705 ------------KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKR 2752 Query: 4065 FLEGTSCIAGVFVDA-----TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 4119 +LEGTSCIAGV V A +E++S+YQAM KG++RPGTA LLEAQAATG+VIDP++ Sbjct: 2753 YLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRN 2812 Query: 4120 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4179 L+L+VEEAV G+VG E ++KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRL Sbjct: 2813 LRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRL 2872 Query: 4180 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4239 LEAQIATGG+IDP SHR+PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTY+ Sbjct: 2873 LEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYV 2932 Query: 4240 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPET----GKEMSVYE-- 4293 QL+ RC+ DP TGL +L L + S+ R V P + G+ +SV+E Sbjct: 2933 QLLRRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELL 2992 Query: 4294 ---------------AYRKGLIDHQ------TYLELSEQECEWEEITISSS--------D 4324 YR G + + T L Q E S Sbjct: 2993 FYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALR 3052 Query: 4325 GVVKSMIIDRRSGRQYDIDDAIAKNLIDRSA----LDQYRAGTLSITEFADMLS------ 4374 + + R GR + D +A + +A L ++ +GTL + L+ Sbjct: 3053 AATMEVKVGRLRGRAVPVWDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAIIEEA 3112 Query: 4375 ---------------------------GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASW 4407 G++G + G + + A +R Q + Sbjct: 3113 EEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQEQTL 3172 Query: 4408 SDPTEET--GPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGI------- 4458 D T E G G VS+ + + + + LL AQ G + Sbjct: 3173 RDATMEVQRGQFQG-------RPVSVWDVLFSSYLSEARRDELL-AQHAAGALGLPDLVA 3224 Query: 4459 ----IDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKG 4514 + T ER ++ +GL ++ ++ + G P T ++ + Sbjct: 3225 VLTRVIEETEER--LSKVSFRGLRRQVSASELHTS-----GILGPETLRDLAQGTKTLQE 3277 Query: 4515 WLYYEAGQRFLEVQYLTGGLIEP--DTPGR---VPLDEALQRGTVDARTAQKLRDVGAYS 4569 ++ +R+LE G++ P D PGR + + +A+ +G + TA L + A + Sbjct: 3278 VTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAAT 3337 Query: 4570 KYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYS 4616 ++ P L++S ++A+ +V +LL +A ++ GY PY+ Sbjct: 3338 GFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL-SAERAVTGYTDPYT 3383 Score = 1179 bits (3049), Expect = 0.0 Identities = 740/1890 (39%), Positives = 1067/1890 (56%), Gaps = 172/1890 (9%) Query: 2782 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2841 +F + VSA L E GIL + +Q L +G +++ R +VR YL+G S+AG++L Sbjct: 234 TFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLL 293 Query: 2842 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2901 K S + A LL GTAL LLEAQAA+ L+DP+ +RL V+EAV+ G+V PELH Sbjct: 294 PEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELH 353 Query: 2902 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2961 +LL AE+AVTG+ DP++G QI LFQAM+KGL+ R +RLL+AQ+ATGG++ P R+ Sbjct: 354 EQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRL 413 Query: 2962 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 3021 P++ A R G DE+ R L+ G F TH L Y QLL CV DPETGL LPL Sbjct: 414 PLEAALRCGCLDEDTQRQLSQA-----GSFSDGTHGGLRYEQLLALCVTDPETGLAFLPL 468 Query: 3022 TDKAAKGGELV---YTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDL 3078 + +GGE + R AT + GKF+G+ V++WE++ SE ++EQR L Sbjct: 469 SG-GPRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAISSEQRAML 527 Query: 3079 LRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQ 3138 +Q++ G ++VEK+ + +E+ R+ F GLR V ELL++ +ID++LY++L+ Sbjct: 528 AQQYQEGTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLE 587 Query: 3139 RGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQ 3198 G+ + +DV + + +R L+G IAG+ L + ++LSIY A K LL A+ LLEAQ Sbjct: 588 HGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQ 647 Query: 3199 AGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3258 A TG IIDP + +V+EA+RA ++GP+ KLLSAE+AVTGY DPYTGQ +SLFQA++ Sbjct: 648 AATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQ 707 Query: 3259 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3318 KGLI RE G+RLL+AQ++TGG++DP SHRVP+DVA RG D+ + L P D K + Sbjct: 708 KGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGF 767 Query: 3319 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3378 DP+T E TY +L +RC D TGL LLPLS + Q L + ++ F+ + V Sbjct: 768 FDPNTHENLTYLQLLERCVRDPETGLYLLPLS-----STQSPLV-DSATQQAFQNLLLSV 821 Query: 3379 PVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQE 3438 G F+G+ V+ WELI+SEYF+ +R++LLR++R +VT+ +V K+L E ET RQ Sbjct: 822 KYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREVTLGQVAKLL-----EAETQRQA 876 Query: 3439 RLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIY 3498 + LR+ V +LL +G++ + +Q+ G + + L + VR L G G + G+ Sbjct: 877 DIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVR 936 Query: 3499 LEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPE 3558 L + +++S+Y+AMR+ LL A LLEAQAATG ++DP + L V EAV+ GVVGPE Sbjct: 937 LLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPE 996 Query: 3559 LHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSH 3618 L+ +L AE A+ G+RDP+SG +S+FQAM+KGL+ + RLLEAQ+ATGGIIDP H Sbjct: 997 LYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHH 1056 Query: 3619 RVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3678 +P+ VA QRGY +EM L+ S+ F P+ +Y QLLE C D +GL LL Sbjct: 1057 HLPMPVAIQRGYVDQEMETALSSSSET---FPTPDGQGRTSYAQLLEECPRDETSGLHLL 1113 Query: 3679 PLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQR 3738 PL + A + TEE+ +R+ + +PG SLW+++ S EEQR Sbjct: 1114 PLPESAPA-------LPTEEQVQRSLQA----VPG----AKDGTSLWDLLSSCHFTEEQR 1158 Query: 3739 AQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLE 3798 L+ D Q GR T +++ + +++T+++ Q R + A L +A II+ E Sbjct: 1159 RGLLEDVQEGRTTVPQLLASVQRWVQETKLL-AQARVMVPGPRGEVPAVWLLDAGIITQE 1217 Query: 3799 TYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVAR 3858 T L +GT+S + E + L+GTG VAGV L S SI QA++ GLL + + Sbjct: 1218 TLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQ 1277 Query: 3859 LLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTIS 3918 LLEAQ A+GFL+DP+ +RL+V++AV+ GLVG EL ++L AERA GY DPY+ ++S Sbjct: 1278 RLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAAGYPDPYSRASLS 1337 Query: 3919 LFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSE-P 3977 L+QAM+K L+P E L LL QLATGG+VDP G HLP A + G L+ T L+ Sbjct: 1338 LWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLLDTQTSQVLTAVD 1397 Query: 3978 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--------SDARKLTFRGLRKQI 4029 + + + DPS ++++Y QL RC D TG LLLPL D + R ++ + Sbjct: 1398 KDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDHTAVALRAMKVPV 1457 Query: 4030 T---------------MEELVRSQVMDEATAL----------QLREGLTSIEEVT----- 4059 + + E V + E AL Q+ +T++ E Sbjct: 1458 STGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQVVSAVTALVEAAERQPL 1517 Query: 4060 ------------------------KNLQKFLEGTSCIAGVF-VDATKERL---------- 4084 K L + +GT+ + V +D+ K L Sbjct: 1518 QATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVL 1577 Query: 4085 --------SVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPE 4136 S+ +A+++ I+RPGTA LLEAQAATG++IDP + KLTVEEA + G+ G E Sbjct: 1578 IQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKE 1637 Query: 4137 FKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESH 4196 KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIATGGIIDP SH Sbjct: 1638 TYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSH 1697 Query: 4197 RLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLL 4256 R+PV+VAY+ G FDEEMN IL DPSDDTKGFFDPNT ENLTYLQL+ERC+ DP+TGL LL Sbjct: 1698 RVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLL 1757 Query: 4257 PLKEK-------KRERKTSSKSSVRKRRV-----------------VIVDPETGKEMSVY 4292 + +K + +S K RV + + + Y Sbjct: 1758 QIIKKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTEDRKRELIQEY 1817 Query: 4293 EAYRKGLIDHQTYLE-----LSEQECEWEEITISSSDGVV------KSMIIDRRSGRQYD 4341 A GL + LE + E E + + I +++ G V S +ID+++ Sbjct: 1818 GAQSGGL---EKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQKTLHTLR 1874 Query: 4342 IDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSR 4401 + + L + Y G +D ++G S+ +S + PA Sbjct: 1875 VGRTGGQALSTLECVKPYLEG-------SDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927 Query: 4402 TQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDP 4461 T L E +LD T +K+S+ EA+ LV+ +RLL+A+ G DP Sbjct: 1928 TWL------LEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDP 1981 Query: 4462 STGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAG 4521 +TG+ P+ A+ K L++K R+ Q A G DP+ ++ A ++G L+ + Sbjct: 1982 ATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIY 2041 Query: 4522 QRFLEVQYLTGGLIEPDTPGRVPLDEALQR 4551 + +++ ++P+T +V E +R Sbjct: 2042 ALISDQKHMRKRFVDPNTQEKVSYRELQER 2071 Score = 1138 bits (2943), Expect = 0.0 Identities = 742/1981 (37%), Positives = 1094/1981 (55%), Gaps = 185/1981 (9%) Query: 2733 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA 2792 EQ +L +Q++ E++ A++++AT L+ AA A +F GLR V+ Sbjct: 522 EQRAMLAQQYQEGTLSVEKL-AAELSAT---------LEQAAATARV--TFSGLRDTVTP 569 Query: 2793 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA 2852 L +A I+ + +RL G T ++ + YLQG IAGLLL + E+LS+Y A Sbjct: 570 GELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEA 629 Query: 2853 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVT 2912 + LL PGTALILLEAQAA+GF++DP N+ +V EA++ V+GP++ KLLSAERAVT Sbjct: 630 RCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVT 689 Query: 2913 GYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 2972 GY DPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF Sbjct: 690 GYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 749 Query: 2973 DEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELV 3032 D+ +N +L DPSDDTKGFFDPNTHENLTYLQLLERCV DPETGL LLPL+ + Sbjct: 750 DQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLSSTQSP----- 804 Query: 3033 YTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKI 3092 DS + F+ +S +G+FQG+ V+ WE+INSEYF+ +RR LLR++R +T+ ++ Sbjct: 805 LVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREVTLGQV 864 Query: 3093 IKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDT 3152 K++ E +++ + LRS V +LLE+ +ID++L Q+ G S + +D Sbjct: 865 AKLLEA---ETQRQADIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDG 921 Query: 3153 VRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSAR 3212 VRR L G + GV L +GQ+LS+Y A+++ LL +A+ALLEAQA TG I+DP + Sbjct: 922 VRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPES 981 Query: 3213 LTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLD 3272 L+VDEAVR G+VGPE + +L AE A+ G+RDP++G+ VS+FQA+KKGLIP EQ RLL+ Sbjct: 982 LSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLE 1041 Query: 3273 AQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGEL 3332 AQ++TGGI+DP+ H +P+ VA RG +D+E ALS+ ++ + P +Y +L Sbjct: 1042 AQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSS---SSETFPTPDGQGRTSYAQL 1098 Query: 3333 QQRCRPDQLTGLSLLPLSEKA-ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVW 3391 + C D+ +GL LLPL E A A +E++ LQA V G K T ++W Sbjct: 1099 LEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQA------------VPGAKDGT-SLW 1145 Query: 3392 ELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPA 3451 +L+SS +FT EQR+ LL + G+ TV +++ + V+E + L Q R+ G R VPA Sbjct: 1146 DLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGEVPA 1205 Query: 3452 SELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEA 3511 LL +G++++ E L G + ++E +V+ L G+GC+AG+ L+ + K SI +A Sbjct: 1206 VWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQA 1265 Query: 3512 MRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVT 3571 +R GLL LLEAQ A+GFLVDP+ NQRL V +AVK G+VG EL EQL AE+A Sbjct: 1266 VRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAA 1325 Query: 3572 GYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYF 3631 GY DPYS +++SL+QAM+KGLV + G+ LL+ Q+ATGG++DPVH +P A + G Sbjct: 1326 GYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLL 1385 Query: 3632 SEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVET 3691 + ++VL D K FFDP+ + +TY+QL ERCV D ETGL LLPL EV + Sbjct: 1386 DTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDH 1445 Query: 3692 TQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVT 3751 T V A ++ + G G ++SLW+++ S+ + ++R +L+A ++GR Sbjct: 1446 TAV--------ALRAMKVPV-STGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAA 1496 Query: 3752 KERMII-IIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSL 3810 R ++ + ++E E RQ A++ +R++++A DLF A++IS +T + L +GT ++ Sbjct: 1497 ALRQVVSAVTALVEAAE--RQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTV 1554 Query: 3811 REALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFL 3870 +E E +S L G +AGV + G+++ +SI +AL++ +L A +LLEAQAATGF+ Sbjct: 1555 KEVAEMDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFI 1614 Query: 3871 LDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPT 3930 +DP + +LTV+EA + G+ G E + +LLSAERAVTGY DPYT Q ISLFQAM+K+LI Sbjct: 1615 IDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVR 1674 Query: 3931 EEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSE-VRSYVDPSTD 3989 E +RLL+AQ+ATGGI+DP +P++VAY+ GY +++ + L++PS+ + + DP+T Sbjct: 1675 EHGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTH 1734 Query: 3990 ERLSYTQLLRRCRRDDGTGQLLLPL--------------------SDARKLTFRGLRKQI 4029 E L+Y QLL RC D TG LL + A+ R + + Sbjct: 1735 ENLTYLQLLERCVEDPETGLYLLQIIKKGENYVYINEATRHVLQSRTAKMRVGRFADQVV 1794 Query: 4030 TMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQA 4089 + +L+ S E + RE + + L+K LE + +E + Q Sbjct: 1795 SFWDLLSSPYFTED---RKRELIQEYGAQSGGLEKLLE-------IITTTIEETETQNQG 1844 Query: 4090 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT 4149 +K IR E+ A VID L V + E L + Sbjct: 1845 IKVAAIRG----EVTAADLFNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSDCIA 1900 Query: 4150 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF 4209 G P + +++SL +A +K LI LLEAQ ATG ++DP +L V+ A GL Sbjct: 1901 GVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLV 1960 Query: 4210 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSS 4269 +EE+ E L G+ DP T + + Q M++ + + L LL Sbjct: 1961 NEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLL------------- 2007 Query: 4270 KSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKS 4329 V+ ++DP+ + + AYR+G + Y +S+Q+ + ++ V Sbjct: 2008 --EVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSY 2065 Query: 4330 MIIDRRSGRQYD---IDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSS 4386 + R Q D + + K D +D L A+ + G FR + + Sbjct: 2066 RELQERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALE----AEQVEITVGRFRGQKPT 2121 Query: 4387 VGS--SSSYPISP------AVSRT----------QLASWSDPTEET--------GPVAGI 4420 + + +S Y + RT QL +ET G I Sbjct: 2122 LWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQI 2181 Query: 4421 LDTETLEKVSITEAM----------HRNLVDNITGQRLLEAQACTGGII-----DPSTGE 4465 +E L ITE M + L+++ +R LE +C G++ P E Sbjct: 2182 TASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQE 2241 Query: 4466 RFPVTDAVNKG-------------------LVDKIMVDRINL------------------ 4488 + + A+ KG ++D + R+++ Sbjct: 2242 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLL 2301 Query: 4489 -AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDE 4547 A++A G+ DP T ++S QA++K + E G R LE Q TGG+I+P RVP+D Sbjct: 2302 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 2361 Query: 4548 ALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQS 4607 A +RG D + L D +K P T ++Y L R + + TGL +L+ A + Sbjct: 2362 AYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRG 2421 Query: 4608 T 4608 + Sbjct: 2422 S 2422 Score = 1040 bits (2688), Expect = 0.0 Identities = 679/1786 (38%), Positives = 979/1786 (54%), Gaps = 160/1786 (8%) Query: 2909 RAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYR 2968 R++ G +GQ S++ AM++GL+ G LLEAQ ATGG++D +PV A + Sbjct: 41 RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100 Query: 2969 RGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG 3028 +G E+ L T G+ DP E L Q + + V D G L + + A G Sbjct: 101 QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEV--QLATG 158 Query: 3029 GELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINS-EYFTAEQRRDLLRQFRTGRI 3087 G + A+ V + G +T W ++ E T + R L R+ Sbjct: 159 GLV----DPAQGVLVAPEPACHQGLLDRET---WHKLSELEPGTGDLR--FLNPNTLERL 209 Query: 3088 TVEKIIKIIITVVEEQEQ--KGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 3145 T ++++ + ++ F + V AAELLE ++D + Q L+ G + Sbjct: 210 TYHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAV 269 Query: 3146 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3205 DV+ VRR L G +AGV L G K S + A + LLP A+ LLEAQA T ++ Sbjct: 270 DVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLV 329 Query: 3206 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3265 DP T RL VDEAVRAGLV PE HE+LL AE+AVTG+ DP++G + LFQA+KKGL+ R Sbjct: 330 DPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRP 389 Query: 3266 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3325 LRLLDAQL+TGG+V P++ R+PL+ A GCLDE+T R LS A ++SD + G Sbjct: 390 LALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLS----QAGSFSDGTHGG 445 Query: 3326 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR-QEELYSELQARETFEKTPVEVPVGGFK 3384 Y +L C D TGL+ LPLS Q + + R+ V VG F+ Sbjct: 446 -LRYEQLLALCVTDPETGLAFLPLSGGPRGGEPQGPPFIKYSTRQALSTATATVSVGKFR 504 Query: 3385 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG 3444 GR V++WEL+ SE ++EQR L +Q++ G ++VEK+ L +E+ R++FSG Sbjct: 505 GRPVSLWELLFSEAISSEQRAMLAQQYQEGTLSVEKLAAELSATLEQAAATA--RVTFSG 562 Query: 3445 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE 3504 LR V ELL + ++ + +E+L+ G+ T KD+ L S + LQG+GC+AG+ L ++E Sbjct: 563 LRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQE 622 Query: 3505 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL 3564 ++SIYEA +GLLR TA +LLEAQAATGF++DP N+ V EA++A V+GP++ +LL Sbjct: 623 RLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLL 682 Query: 3565 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV 3624 SAE+AVTGY DPY+G ISLFQAMQKGL++R+HGIRLLEAQIATGG+IDPVHSHRVPVDV Sbjct: 683 SAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 742 Query: 3625 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE 3684 AY+RGYF + +N +L DPSDDTKGFFDPNTHENLTY QLLERCV DPETGL LLPL + Sbjct: 743 AYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLSSTQ 802 Query: 3685 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD 3744 V + T++AF+ + + G G +S WE++ S+ E +R QL+ Sbjct: 803 SPLV--------DSATQQAFQNLLLSVK-YGRFQGQRVSAWELINSEYFSEGRRRQLLRR 853 Query: 3745 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR 3804 ++ VT ++ ++ + E RQ + +R R+T L EA II + + + Sbjct: 854 YRQREVTLGQVAKLL-----EAETQRQADI-MLPALRSRVTVHQLLEAGIIDQQLLDQVL 907 Query: 3805 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ 3864 GT S L + YL G G+V GV L S Q LS+YQA+++ LL VA LLEAQ Sbjct: 908 AGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQ 967 Query: 3865 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK 3924 AATG ++DP E L+VDEAVR+G+VGPEL+ RL AE A+ G+RDP++ + +S+FQAMK Sbjct: 968 AATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMK 1027 Query: 3925 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV 3984 K LIP E+A RLL+AQ+ATGGI+DP HLP+ VA QRGY++++ LS SE ++ Sbjct: 1028 KGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSSSSE--TFP 1085 Query: 3985 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDA-----------RKL-TFRGLRKQITME 4032 P R SY QLL C RD+ +G LLPL ++ R L G + ++ Sbjct: 1086 TPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPGAKDGTSLW 1145 Query: 4033 ELVRSQVMDEATALQL----REGLTSIEEVTKNLQKFLEGTSCI---------------- 4072 +L+ S E L +EG T++ ++ ++Q++++ T + Sbjct: 1146 DLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGEVPA 1205 Query: 4073 -----AGVFVDATKERL--------------------------------------SVYQA 4089 AG+ T E L S+ QA Sbjct: 1206 VWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQA 1265 Query: 4090 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT 4149 ++ G++ G LLEAQ A+G+++DP+ +L+VE+AV++G+VG E ++L AERA Sbjct: 1266 VRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAA 1325 Query: 4150 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF 4209 GY DPYS +SL+QAM+KGL+ ++ G+ LL+ Q+ATGG++DP LP A + GL Sbjct: 1326 GYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLL 1385 Query: 4210 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPL-KEKKRERKTS 4268 D + +++LT D K FFDP+ + +TY QL ERC+ D +TGL LLPL + E Sbjct: 1386 DTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDH 1445 Query: 4269 SKSSVRKRRV-VIVDPETGKEMSVYEAYRKGLIDHQTYLEL-----SEQECEWEEITISS 4322 + ++R +V V G +S+++ + EL S + ++ +S+ Sbjct: 1446 TAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQV-VSA 1504 Query: 4323 SDGVVKS------MIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGN 4376 +V++ R +Q D LI R LD+ GT ++ E A+M Sbjct: 1505 VTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEM---- 1560 Query: 4377 AGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMH 4436 +V R+ E +AG+L T E++SI EA+ Sbjct: 1561 --------------------DSVKRS--------LEGGNFIAGVLIQGTQERMSIPEALR 1592 Query: 4437 RNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGF 4496 R+++ T LLEAQA TG IIDP+ + V +A G+ K ++ A++A G+ Sbjct: 1593 RHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGY 1652 Query: 4497 EDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDA 4556 DP T ++S QA++K + E G R LE Q TGG+I+P RVP+D A + G D Sbjct: 1653 TDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDE 1712 Query: 4557 RTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLE 4602 + L D +K P T ++Y L+R + + TGL LL+ Sbjct: 1713 EMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQ 1758 Score = 735 bits (1898), Expect = 0.0 Identities = 653/2071 (31%), Positives = 970/2071 (46%), Gaps = 337/2071 (16%) Query: 2717 RRQQEELLAE------ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770 R +EELLAE + L +L + E+ A ++ ++ + P GR Sbjct: 2547 RAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDARRGPREPGPAGRG-- 2604 Query: 2771 DGPAAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAE-ELQR-LAQGHTT--------- 2815 DG + ++ E +G ++ +A R QE + A E+QR QG Sbjct: 2605 DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS 2664 Query: 2816 -VDELARREDVRHYLQGRSSIAGLL------LKATNEKLSV--YAALQRQLLSPGTALIL 2866 + E R E + + G + L+ ++ T E+LS + L+RQ+ + Sbjct: 2665 YLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSA------- 2717 Query: 2867 LEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQ----- 2921 ++ + +L P R L + V + + L + G P Q Sbjct: 2718 --SELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQE 2775 Query: 2922 QISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLA 2981 ++S++QAM KG++ + LLEAQ ATG VIDPV + R+ V+ A G E+ L Sbjct: 2776 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL 2835 Query: 2982 DPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDV 3041 G+ DP T + ++ Q +++ + E G+ LL + A GG + D Sbjct: 2836 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA--QIATGGVI--------DP 2885 Query: 3042 FEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVE 3101 V +G YF E R L + + +T V+ Sbjct: 2886 VHSHRVPVDVAYRRG------------YFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQ 2933 Query: 3102 EQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQ-QLQRGERSVRDVAEVDTVRRALRGA 3160 LR VP D LY QL +V ++E +R ALR A Sbjct: 2934 L-----------LRRCVPDP--------DTGLYMLQLAGRGSAVHQLSE--ELRCALRDA 2972 Query: 3161 NVIAGVWLEEAGQKLSIYNAL---------KKDLLPSDMAVALLEAQAGTGHIIDPATSA 3211 V G + GQ +S++ L ++DLL A L + G + A Sbjct: 2973 RVTPGSGALQ-GQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGAT-LTSLLAQA 3030 Query: 3212 RLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLL 3271 + AG P+ E L +A V R G++V ++ L G + LL Sbjct: 3031 QAQARAEAEAGSPRPDPREALRAATMEVKVGR--LRGRAVPVWDVLASGYVSGAAREELL 3088 Query: 3272 DAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGE 3331 A+ +G + P+ + R+ + EE A A A+ P PA G+ Sbjct: 3089 -AEFGSGTLDLPALTRRLTAII--------EEAEEAPGARPQLQDAWRGPREPGPAGRGD 3139 Query: 3332 LQ--QRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVT 3389 + R Q G + + AA RQE+ T +EV G F+GR V+ Sbjct: 3140 GDSGRSQREGQGEGETQEAAAAAAAARRQEQ---------TLRDATMEVQRGQFQGRPVS 3190 Query: 3390 VWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPV 3449 VW+++ S Y + +R ELL Q G + + ++ +L ++EE E R ++SF GLR V Sbjct: 3191 VWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEE-RLSKVSFRGLRRQV 3249 Query: 3450 PASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLE-----DTKE 3504 ASEL SG+L L G T+++++E+ SV+ L+G+ C+AG+ + +E Sbjct: 3250 SASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQE 3309 Query: 3505 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL 3564 K+SIY+AM +G+LR TA +LLEAQAATGF++DPVRN RL V EAV AGVVG E+ E+LL Sbjct: 3310 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL 3369 Query: 3565 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV 3624 SAE+AVTGY DPY+G ISLFQAMQK L++R+HGIRLLEAQIATGG+IDPVHSHRVPVDV Sbjct: 3370 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 3429 Query: 3625 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE 3684 AY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL RCV DP+TGL +L L G Sbjct: 3430 AYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRG 3489 Query: 3685 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD 3744 A EE R A + ++ PG G+ G ++S+WE++ + E++R L++ Sbjct: 3490 SA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVWELLFYREVSEDRRQDLLSR 3542 Query: 3745 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR 3804 ++AG +T E + + ++ + + + R A EA + LR Sbjct: 3543 YRAGTLTVEELGATLTSLLAQAQ------------AQARAEA----EAGSPRPDPREALR 3586 Query: 3805 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ 3864 T ++ G + G +P ++ L G +S AR L A+ Sbjct: 3587 AATMEVK--------------VGRLRGRAVP-------VWDVLASGYVSG-AAREELLAE 3624 Query: 3865 AATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER---AVTGYRDPYTEQTISL 3919 +G L P RLT ++EA P+L D A G D Q Sbjct: 3625 FGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQ 3684 Query: 3920 FQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV--AYQRGYLNKDTHDQ--- 3973 + +E A R + L + R F P+ V YL++ D+ Sbjct: 3685 GEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDELLA 3744 Query: 3974 --------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGL 4025 L + V + V T+ERLS K++FRGL Sbjct: 3745 QHAAGALGLPDLVAVLTRVIEETEERLS-------------------------KVSFRGL 3779 Query: 4026 RKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQKFLEGTSCIAGVFVDA---- 4079 R+Q++ EL S ++ T L +G +++EVT+ +++++LEGTSCIAGV V A Sbjct: 3780 RRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQP 3839 Query: 4080 -TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFK 4138 +E++S+YQAM KG++RPGTA LLEAQAATG+VIDP++ L+L+VEEAV G+VG E + Sbjct: 3840 GRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQ 3899 Query: 4139 DKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRL 4198 +KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIATGG+IDP SHR+ Sbjct: 3900 EKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRV 3959 Query: 4199 PVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPL 4258 PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTY+QL+ RC+ DP TGL +L L Sbjct: 3960 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL 4019 Query: 4259 KEKKRERKTSSKSSVRKRRVVIVDPET----GKEMSVYEA--YRKGLIDHQTYLELSEQE 4312 + S+ R V P + G+ +SV+E YR+ D + L LS Sbjct: 4020 AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDL-LSRYR 4078 Query: 4313 CEWEEITISSSDGVVKSMI--------------------------------IDRRSGRQY 4340 +T+ + S++ + R GR Sbjct: 4079 A--STLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAV 4136 Query: 4341 DIDDAIAKNLIDRSA----LDQYRAGTLSITEFADMLS---------------------- 4374 + D +A + R+A L ++ +GTL + L+ Sbjct: 4137 PVWDVLASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRG 4196 Query: 4375 -----------GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEET--GPVAGIL 4421 G++G + G + + A +R Q + D T E G G Sbjct: 4197 PREPGPAGRGDGDSGRSQREGQGEGETQEAAAATAAARRQEQTLRDATMEVQRGQFQG-- 4254 Query: 4422 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGI-----------IDPSTGERFPVT 4470 VS+ + + + + LL AQ G + + T ER ++ Sbjct: 4255 -----RPVSVWDVLFSSYLSEARRDELL-AQHAAGALGLPDLVAVLTRVIEETEER--LS 4306 Query: 4471 DAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYL 4530 +GL ++ ++ + G P T ++ + ++ +R+LE Sbjct: 4307 KVSFRGLRRQVSASELHTS-----GILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSC 4361 Query: 4531 TGGLIEP--DTPGR---VPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKD 4585 G++ P D PGR + + +A+ +G + TA L + A + ++ P L++S ++ Sbjct: 4362 IAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEE 4421 Query: 4586 ALDRSMVEEGTGLRLLEAAAQSTKGYYSPYS 4616 A+ +V +LL +A ++ GY PY+ Sbjct: 4422 AVAAGVVGGEIQEKLL-SAERAVTGYTDPYT 4451 Score = 727 bits (1876), Expect = 0.0 Identities = 710/2292 (30%), Positives = 1038/2292 (45%), Gaps = 316/2292 (13%) Query: 2062 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE-QAELEAARQRQLAAEEERRR 2120 EE+ A S A +A E E G R + + LR+ + ++ R R + + Sbjct: 3017 EELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPVWDVLAS 3076 Query: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-QLQLAQEA 2179 ++ L AE + AL RL A +EEA E AR QLQ A Sbjct: 3077 GYVSGAAREELLAEFGSGTLDLPAL--TRRLTAIIEEAE------EAPGARPQLQDAWRG 3128 Query: 2180 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2239 ++ A Q+E + + Q+ + A AARR + +A ++ +R Sbjct: 3129 PREPGPAGRGDGDSGRSQREGQGEGETQEAAAA-------AAAARRQEQTLRDATMEVQR 3181 Query: 2240 EAAQSR----------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2289 Q R + EA R + A+ A A A L + E+ R ++ Sbjct: 3182 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAV-LTRVIEETEERLSKV 3240 Query: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2349 LR +Q + +E+ +TLR AQ + L ++ E D K L E + Sbjct: 3241 SFRGLR-RQVSASELHTSGILGPETLRDLAQGTKTLQ----EVTEMDSVKRYL-EGTSCI 3294 Query: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2409 A Q + E+ M + + AL+L + F+ + Sbjct: 3295 AGVLVPAKDQPGRQEK--------MSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRN 3346 Query: 2410 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2469 ++ EEA V E ++EK+ + + A + Sbjct: 3347 LRLSVEEAVAAGVVGGE----------------------IQEKLLSAERAVTGYTDPYTG 3384 Query: 2470 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2529 QQ ++ QA M + L G R LEA Q+ + + + Sbjct: 3385 QQ---ISLFQA---------MQKDLIVREHGI-RLLEA----QIATGGVIDPVHSHRVPV 3427 Query: 2530 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2589 A R D + R A+ + + T E +T VQ L +R D D + Sbjct: 3428 DVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLL--RRCVPDPDTGLYMLQL 3485 Query: 2590 AELEREKEKLQQEAK--LLQLKSEEMQTVQQEQLLQETQALQQSFLSE--KDSLLQRERF 2645 A +L +E + L + Q Q + + L +SE + LL R R Sbjct: 3486 AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRA 3545 Query: 2646 IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704 +L +A+AQ Q R E + + + A+ME R V Sbjct: 3546 GTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPV- 3604 Query: 2705 RKQEELQQLEQQRRQQEELLAE------ENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758 + L +EELLAE + L +L + E+ A ++ + Sbjct: 3605 --WDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRG 3662 Query: 2759 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAE-ELQR-LAQG 2812 + P GR DG + ++ E +G ++ +A R QE + A E+QR QG Sbjct: 3663 PREPGPAGRG--DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQG 3720 Query: 2813 HTT----------VDELARREDVRHYLQGRSSIAGLL------LKATNEKLSV--YAALQ 2854 + E R E + + G + L+ ++ T E+LS + L+ Sbjct: 3721 RPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 3780 Query: 2855 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2914 RQ+ + ++ + +L P R L + V + + L + G Sbjct: 3781 RQVSA---------SELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3831 Query: 2915 KDPYTGQ-----QISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRR 2969 P Q ++S++QAM KG++ + LLEAQ ATG VIDPV + R+ V+ A Sbjct: 3832 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3891 Query: 2970 GYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGG 3029 G E+ L G+ DP T + ++ Q +++ + E G+ LL + A GG Sbjct: 3892 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA--QIATGG 3949 Query: 3030 ELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITV 3089 + D V +G YF E R L + Sbjct: 3950 VI--------DPVHSHRVPVDVAYRRG------------YFDEEMNRVLADPSDDTKGFF 3989 Query: 3090 EKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQ-QLQRGERSVRDVA 3148 + +T V+ LR VP D LY QL +V ++ Sbjct: 3990 DPNTHENLTYVQL-----------LRRCVPDP--------DTGLYMLQLAGRGSAVHQLS 4030 Query: 3149 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNAL---------KKDLLPSDMAVALLEAQA 3199 E +R ALR A V G + GQ +S++ L ++DLL A L + Sbjct: 4031 E--ELRCALRDARVTPGSGALQ-GQSVSVWELLFYREVSEDRRQDLLSRYRASTLTVEEL 4087 Query: 3200 GTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKK 3259 G + A+ AG P+ E L +A V R G++V ++ L Sbjct: 4088 GAT-LTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGR--LRGRAVPVWDVLAS 4144 Query: 3260 GLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYS 3319 G + R LL A+ +G + P+ + R+ + EE A A A+ Sbjct: 4145 GYVSRAAREELL-AEFGSGTLDLPALTRRLTAII--------EEAEEAPGARPQLQDAWR 4195 Query: 3320 DPSTGEPATYGELQ--QRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE 3377 P PA G+ + R Q G + + AA RQE+ T +E Sbjct: 4196 GPREPGPAGRGDGDSGRSQREGQGEGETQEAAAATAAARRQEQ---------TLRDATME 4246 Query: 3378 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ 3437 V G F+GR V+VW+++ S Y + +R ELL Q G + + ++ +L ++EE E R Sbjct: 4247 VQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEE-RL 4305 Query: 3438 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI 3497 ++SF GLR V ASEL SG+L L G T+++++E+ SV+ L+G+ C+AG+ Sbjct: 4306 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4365 Query: 3498 YLE-----DTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKA 3552 + +EK+SIY+AM +G+LR TA +LLEAQAATGF++DPVRN RL V EAV A Sbjct: 4366 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4425 Query: 3553 GVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGII 3612 GVVG E+ E+LLSAE+AVTGY DPY+G ISLFQAMQK L++R+HGIRLLEAQIATGG+I Sbjct: 4426 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 4485 Query: 3613 DPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPE 3672 DPVHSHRVPVDVAY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL RCV DP+ Sbjct: 4486 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4545 Query: 3673 TGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDL 3732 TGL +L L G A EE R A + ++ PG G+ G ++S+WE++ Sbjct: 4546 TGLYMLQLAGRGSA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVWELLFYRE 4598 Query: 3733 IPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEA 3792 + E++R L++ ++AG +T E + + ++ + + + R A EA Sbjct: 4599 VSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQ------------AQARAEA----EA 4642 Query: 3793 RIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLL 3852 + LR T ++ G + G +P ++ L G + Sbjct: 4643 GSPRPDPREALRAATMEVK--------------VGRLRGRAVP-------VWDVLASGYV 4681 Query: 3853 SAEVARLLLEAQAATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER---AVTG 3907 S AR L A+ +G L P RLT ++EA P+L D A G Sbjct: 4682 SG-AAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRG 4740 Query: 3908 YRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV--AYQRG 3964 D Q + +E A R + L + R F P+ V Sbjct: 4741 DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS 4800 Query: 3965 YLNKDTHDQ-----------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 4013 YL++ D+ L + V + V T+ERLS Sbjct: 4801 YLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLS-------------------- 4840 Query: 4014 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQKFLEGTSC 4071 K++FRGLR+Q++ EL S ++ T L +G +++EVT+ +++++LEGTSC Sbjct: 4841 -----KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSC 4895 Query: 4072 IAGVFVDA-----TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEE 4126 IAGV V A +E++S+YQAM KG++RPGTA LLEAQAATG+VIDP++ L+L+VEE Sbjct: 4896 IAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEE 4955 Query: 4127 AVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIAT 4186 AV G+VG E ++KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIAT Sbjct: 4956 AVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIAT 5015 Query: 4187 GGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCI 4246 GG+IDP SHR+PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTYLQL++R Sbjct: 5016 GGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRAT 5075 Query: 4247 TDPQTGLCLLPL 4258 DP+TGL L L Sbjct: 5076 LDPETGLLFLSL 5087 Score = 546 bits (1406), Expect = e-154 Identities = 434/1449 (29%), Positives = 677/1449 (46%), Gaps = 192/1449 (13%) Query: 3237 KAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACA 3296 +++ G +GQ+ S++ A+++GL+P G LL+AQ +TGG+VD ++ +P+ A Sbjct: 41 RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100 Query: 3297 RGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPL------- 3349 +G + E L A Y DP GE + + D+ G S L + Sbjct: 101 QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGGL 160 Query: 3350 ---SEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3406 ++ A + + L RET+ K L E T + R Sbjct: 161 VDPAQGVLVAPEPACHQGLLDRETWHK-------------------LSELEPGTGDLR-- 199 Query: 3407 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3466 L ++T ++++ + L +++F + V A+ELL G+L + Sbjct: 200 FLNPNTLERLTYHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQ 259 Query: 3467 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3526 L++G+ D+S VR L+G+G +AG+ L K S ++A LL TA LL Sbjct: 260 GLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLL 319 Query: 3527 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3586 EAQAAT LVDP+ QRL+V EAV+AG+V PELHEQLL AE+AVTG+ DP+SGS I LFQ Sbjct: 320 EAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQ 379 Query: 3587 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3646 AM+KGLV R +RLL+AQ+ATGG++ P R+P++ A + G E+ R L+ Sbjct: 380 AMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQA---- 435 Query: 3647 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3706 G F TH L Y QLL CV DPETGL LPL G + + + + TR+A Sbjct: 436 -GSFSDGTHGGLRYEQLLALCVTDPETGLAFLPLSGGPRGGEPQGPP-FIKYSTRQALST 493 Query: 3707 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKT 3766 + G G +SLWE++ S+ I EQRA L +Q G ++ E++ + +E+ Sbjct: 494 ATATV-SVGKFRGRPVSLWELLFSEAISSEQRAMLAQQYQEGTLSVEKLAAELSATLEQA 552 Query: 3767 EIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGT 3826 + ++ +R +T +L +A II + Y L G + ++ SA YL GT Sbjct: 553 AATAR---VTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGT 609 Query: 3827 GSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVR 3886 G +AG+ LPGS++ LSIY+A KGLL A +LLEAQAATGF++DP + +V+EA+R Sbjct: 610 GCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALR 669 Query: 3887 KGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGI 3946 ++GP++ +LLSAERAVTGY DPYT Q ISLFQAM+K LI E +RLL+AQ+ATGG+ Sbjct: 670 AAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGV 729 Query: 3947 VDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSE-VRSYVDPSTDERLSYTQLLRRCRRDD 4005 +DP +P++VAY+RGY ++ + L +PS+ + + DP+T E L+Y QLL RC RD Sbjct: 730 IDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDP 789 Query: 4006 GTGQLLLPLSD--------ARKLTFRGLR----------KQITMEELVRSQVMDEATALQ 4047 TG LLPLS A + F+ L ++++ EL+ S+ E Q Sbjct: 790 ETGLYLLPLSSTQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQ 849 Query: 4048 LREGLTSIEEVTKNLQKFLEG-TSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEA 4106 L E + K LE T A + + A + R++V+Q ++ GII + Sbjct: 850 LLRRYRQREVTLGQVAKLLEAETQRQADIMLPALRSRVTVHQLLEAGII---------DQ 900 Query: 4107 QAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAM 4166 Q + I L + + VR + L AV G + SG+ +SL+QAM Sbjct: 901 QLLDQVLAGTISPEALLLMDGVR----------RYLCGLGAVGGVRLLPSGQRLSLYQAM 950 Query: 4167 KKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKG 4226 ++ L+ + LLEAQ ATG I+D Sbjct: 951 RQKLLGPRVALALLEAQAATGTIMD----------------------------------- 975 Query: 4227 FFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETG 4286 P++ E+L+ + + R + P+ + +R + + R DP +G Sbjct: 976 ---PHSPESLSVDEAVRRGVVGPEL--------YGRLKRAEGAIAGFR-------DPFSG 1017 Query: 4287 KEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAI 4346 K++SV++A +KGLI WE+ V IID S + AI Sbjct: 1018 KQVSVFQAMKKGLIP-------------WEQAARLLEAQVATGGIIDPTSHHHLPMPVAI 1064 Query: 4347 AKNLIDRSALDQYRAGTLSI--------TEFADMLSGNAGGFRSRSSSVGSSSSYPISPA 4398 + +D+ + + + T +A +L S + S P P Sbjct: 1065 QRGYVDQEMETALSSSSETFPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPT 1124 Query: 4399 VSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG-- 4456 + Q + + P G G + L TE R L++++ R Q Sbjct: 1125 EEQVQRSLQAVP----GAKDGTSLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQ 1180 Query: 4457 ------------GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGF-EDPRTKT 4503 ++ P P ++ G++ + ++ + ++ E P K Sbjct: 1181 RWVQETKLLAQARVMVPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKA 1240 Query: 4504 ------------------KMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPL 4545 K S AQA++ G L GQR LE Q +G L++P R+ + Sbjct: 1241 CLWGTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSV 1300 Query: 4546 DEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAA 4605 ++A++ G V +++L + P ++ +S A+++ +V + GL LL+ Sbjct: 1301 EDAVKVGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQL 1360 Query: 4606 QSTKGYYSP 4614 +T G P Sbjct: 1361 -ATGGVVDP 1368 Score = 459 bits (1182), Expect = e-128 Identities = 444/1446 (30%), Positives = 666/1446 (46%), Gaps = 242/1446 (16%) Query: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730 + +++ Q E E Q A+ ARR+ E+ +R E+Q+ + Q R + Sbjct: 2610 RSQREGQGEGETQEAAAAAAAARRQ----EQTLRDATMEVQRGQFQGRPVSVWDVLFSSY 2665 Query: 2731 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP---EHSFDGLR 2787 L E A +E+ A A LP+ L E E + SF GLR Sbjct: 2666 LSE-------------ARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 2712 Query: 2788 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN--- 2844 R+VSA L +GIL E L+ LAQG T+ E+ + V+ YL+G S IAG+L+ A + Sbjct: 2713 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 2772 Query: 2845 --EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHH 2902 EK+S+Y A+ + +L PGTAL+LLEAQAA+GF++DPVRN RL+V EAV GVVG E+ Sbjct: 2773 RQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQE 2832 Query: 2903 KLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2962 KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVP Sbjct: 2833 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2892 Query: 2963 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLT 3022 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTY+QLL RCV DP+TGL +L L Sbjct: 2893 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL- 2951 Query: 3023 DKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQF 3082 A +G + E R A V+ G QG++V++WE++ + ++R+DLL ++ Sbjct: 2952 --AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRY 3009 Query: 3083 RTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGER 3142 R G +TVE++ + +++ + + + R AE R RE + Sbjct: 3010 RAGTLTVEELGATLTSLLAQAQAQAR----------AEAEAGSPRPDPREALR------- 3052 Query: 3143 SVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTG 3202 A ++ LRG V VW A +S A +++LL A+ G+G Sbjct: 3053 ----AATMEVKVGRLRGRAV--PVWDVLASGYVS--GAAREELL----------AEFGSG 3094 Query: 3203 HIIDPATSARLT--VDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKG 3260 + PA + RLT ++EA A P+ +D + G Sbjct: 3095 TLDLPALTRRLTAIIEEAEEAPGARPQL--------------QDAWRG------------ 3128 Query: 3261 LIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSD 3320 PRE G + G D +S R G + ET A +A A A Sbjct: 3129 --PREPG-------PAGRGDGDSGRSQR--------EGQGEGETQEAAAAA---AAARRQ 3168 Query: 3321 PSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQA------------R 3368 T AT E+Q+ + + + S + AR++EL ++ A Sbjct: 3169 EQTLRDATM-EVQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLT 3227 Query: 3369 ETFEKTPVEVPVGGFKG--RTVTVWELISSEYFTAEQRQELLRQFRT-GKVT-VEKVIKI 3424 E+T + F+G R V+ EL +S E ++L + +T +VT ++ V + Sbjct: 3228 RVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRY 3287 Query: 3425 L--------ITIVEEVETLRQERLS-----FSGLRAPVPASELLASGVLSRAQFEQLKDG 3471 L + + + + RQE++S + G+ P A LL + + + +++ Sbjct: 3288 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 3347 Query: 3472 KTTVKDLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3526 + +V++ G V LL + G T +++S+++AM++ L+ LL Sbjct: 3348 RLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 3407 Query: 3527 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3586 EAQ ATG ++DPV + R+ V A + G E++ L G+ DP + ++ Q Sbjct: 3408 EAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQ 3467 Query: 3587 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLAD----P 3642 +++ + G+ +L Q+A G VH SEE+ L D P Sbjct: 3468 LLRRCVPDPDTGLYML--QLAGRG--SAVHQ-------------LSEELRCALRDARVTP 3510 Query: 3643 SDDTKGFFDPNTHENLTYRQLLERCVED------------PETGLRLLPLKGAEKAEV-V 3689 + E L YR++ E +D E G L L +A+ Sbjct: 3511 GSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARA 3570 Query: 3690 ETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGR 3749 E + R A +++ G G + +W+V+ S + R +L+A+F +G Sbjct: 3571 EAEAGSPRPDPREALRAATMEVKVGRLR-GRAVPVWDVLASGYVSGAAREELLAEFGSGT 3629 Query: 3750 V---TKERMIIIIIEIIEKTEIIRQQ--------------GLASYDYVRRRL------TA 3786 + R + IIE E+ R Q G D R + Sbjct: 3630 LDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGET 3689 Query: 3787 EDLFEARIISLETYNLLREGTRSLREAL---EAESAWCYLYGTGSVAGVYLPGSR--QTL 3841 ++ A + LR+ T ++ S W L+ + YL +R + L Sbjct: 3690 QEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS------YLSEARRDELL 3743 Query: 3842 SIYQALKKGL--LSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE-LHD-- 3896 + + A GL L A + R++ E + + +++ E G++GPE L D Sbjct: 3744 AQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLA 3803 Query: 3897 ----------------RLLSAERAVTGYRDPYTEQ-----TISLFQAMKKELIPTEEALR 3935 R L + G P +Q +S++QAM K ++ AL Sbjct: 3804 QGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALV 3863 Query: 3936 LLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQ-LSEPSEVRSYVDPSTDERLSY 3994 LL+AQ ATG ++DP L +E A G + + ++ LS V Y DP T +++S Sbjct: 3864 LLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISL 3923 Query: 3995 TQLLRR 4000 Q +++ Sbjct: 3924 FQAMQK 3929 Score = 446 bits (1147), Expect = e-124 Identities = 449/1552 (28%), Positives = 699/1552 (45%), Gaps = 266/1552 (17%) Query: 2599 LQQEAKLLQLKSEEMQTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLE 2654 + +E + LK+E T ++ +T QA+Q+ + + ++L R +E + A Sbjct: 1960 VNEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEAL----RLLEVQVATGG 2015 Query: 2655 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714 + + +L E ++ + ++ L++ + R+R + + ELQ+ Sbjct: 2016 VI---DPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSYRELQERC 2072 Query: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----------- 2763 + + +L N+ R+ + +E RA A E+T + K Sbjct: 2073 RPQEDTGWVLFPVNKAARDSEHIDDETRRALEAEQVEITVGRFRGQKPTLWALLNSEYVT 2132 Query: 2764 ------------PNGRDALDGPA---------AEAEPEHS-FDGLRRKVSAQRLQEAGIL 2801 + R AL A E +H F G+RR+++A L + I+ Sbjct: 2133 EEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAII 2192 Query: 2802 SAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN-----EKLSVYAALQRQ 2856 + E LQ L G +T EL + V+ YL+G S IAG+L+ A + EK+S+Y A+ + Sbjct: 2193 TEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKG 2252 Query: 2857 LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKD 2916 +L PGTAL+LLEAQAA+GF++DPVRN RL+V E V GVVG E+ KLLSAERAVTGY D Sbjct: 2253 VLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTD 2312 Query: 2917 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM 2976 PYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM Sbjct: 2313 PYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM 2372 Query: 2977 NRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDS 3036 NRVLADPSDDTKGFFDPNTHENLTY+QLL RCV DP+TGL +L L A +G + Sbjct: 2373 NRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL---AGRGSAVHQLSE 2429 Query: 3037 EARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII 3096 E R A V+ G QG++V++WE++ + ++R+DLL ++R G +TVE++ + Sbjct: 2430 ELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGATL 2489 Query: 3097 ITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRA 3156 +++ + + + R AE R RE + A ++ Sbjct: 2490 TSLLAQAQAQAR----------AEAEAGSPRPDPREALR-----------AATMEVKVGR 2528 Query: 3157 LRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLT-- 3214 LRG V VW A +S A +++LL A+ G+G + PA + RLT Sbjct: 2529 LRGRAV--PVWDVLASGYVS--RAAREELL----------AEFGSGTLDLPALTRRLTAI 2574 Query: 3215 VDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQ 3274 ++EA A P+ Q ++G PRE G Sbjct: 2575 IEEAEEAPGARPQ--------------------------LQDARRG--PREPG------- 2599 Query: 3275 LSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQ 3334 + G D +S R G + ET A +A A A T AT E+Q+ Sbjct: 2600 PAGRGDGDSGRSQR--------EGQGEGETQEAAAAA---AAARRQEQTLRDATM-EVQR 2647 Query: 3335 RCRPDQLTGLSLLPLSEKAARARQEELYSELQA------------RETFEKTPVEVPVGG 3382 + + + S + AR++EL ++ A E+T + Sbjct: 2648 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVS 2707 Query: 3383 FKG--RTVTVWELISSEYFTAEQRQELLRQFRT-GKVT-VEKVIKIL--------ITIVE 3430 F+G R V+ EL +S E ++L + +T +VT ++ V + L + + Sbjct: 2708 FRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPA 2767 Query: 3431 EVETLRQERLS-----FSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV- 3484 + + RQE++S + G+ P A LL + + + +++ + +V++ G V Sbjct: 2768 KDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVG 2827 Query: 3485 ----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3540 LL + G T +++S+++AM++ L+ LLEAQ ATG ++DPV Sbjct: 2828 GEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVH 2887 Query: 3541 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3600 + R+ V A + G E++ L G+ DP + ++ Q +++ + G+ Sbjct: 2888 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLY 2947 Query: 3601 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLAD----PSDDTKGFFDPNTHE 3656 +L Q+A G VH SEE+ L D P + E Sbjct: 2948 ML--QLAGRG--SAVHQ-------------LSEELRCALRDARVTPGSGALQGQSVSVWE 2990 Query: 3657 NLTYRQLLERCVED------------PETGLRLLPLKGAEKAEV-VETTQVYTEEETRRA 3703 L YR++ E +D E G L L +A+ E + R A Sbjct: 2991 LLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREA 3050 Query: 3704 FEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRV---TKERMIIIII 3760 +++ G G + +W+V+ S + R +L+A+F +G + R + II Sbjct: 3051 LRAATMEVKVGRLR-GRAVPVWDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAII 3109 Query: 3761 EIIEKTEIIRQQ--------------GLASYDYVRRRL------TAEDLFEARIISLETY 3800 E E+ R Q G D R + ++ A + Sbjct: 3110 EEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQE 3169 Query: 3801 NLLREGTRSLREAL---EAESAWCYLYGTGSVAGVYLPGSR--QTLSIYQALKKGL--LS 3853 LR+ T ++ S W L+ + YL +R + L+ + A GL L Sbjct: 3170 QTLRDATMEVQRGQFQGRPVSVWDVLFSS------YLSEARRDELLAQHAAGALGLPDLV 3223 Query: 3854 AEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE-LHD---------------- 3896 A + R++ E + + +++ E G++GPE L D Sbjct: 3224 AVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDS 3283 Query: 3897 --RLLSAERAVTGYRDPYTEQ-----TISLFQAMKKELIPTEEALRLLDAQLATGGIVDP 3949 R L + G P +Q +S++QAM K ++ AL LL+AQ ATG ++DP Sbjct: 3284 VKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDP 3343 Query: 3950 RLGFHLPLEVAYQRGYLNKDTHDQ-LSEPSEVRSYVDPSTDERLSYTQLLRR 4000 L +E A G + + ++ LS V Y DP T +++S Q +++ Sbjct: 3344 VRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQK 3395 Score = 350 bits (897), Expect = 2e-95 Identities = 286/925 (30%), Positives = 449/925 (48%), Gaps = 106/925 (11%) Query: 3045 ATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQE 3104 AT+ G+FQG+ V++W+++ S Y + +R +LL Q G + + ++ ++ V+EE E Sbjct: 4243 ATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETE 4302 Query: 3105 QK-GRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVI 3163 ++ ++ F GLR V A+EL S ++ E + L +G +++++V E+D+V+R L G + I Sbjct: 4303 ERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCI 4362 Query: 3164 AGVWLEEAGQ-----KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEA 3218 AGV + Q K+SIY A+ K +L A+ LLEAQA TG +IDP + RL+V+EA Sbjct: 4363 AGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEA 4422 Query: 3219 VRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTG 3278 V AG+VG E EKLLSAE+AVTGY DPYTGQ +SLFQA++K LI RE G+RLL+AQ++TG Sbjct: 4423 VAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATG 4482 Query: 3279 GIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRP 3338 G++DP SHRVP+DVA RG DEE +R L+ P D K + DP+T E TY +L +RC P Sbjct: 4483 GVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVP 4542 Query: 3339 DQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEY 3398 D TGL +L L+ + + Q L EL+ V G +G++V+VWEL+ Sbjct: 4543 DPDTGLYMLQLAGRGSAVHQ--LSEELRC--ALRDARVTPGSGALQGQSVSVWELLFYRE 4598 Query: 3399 FTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG 3458 + ++RQ+LL ++R G +TVE++ L +++ + + + +G P P L Sbjct: 4599 VSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAE-AGSPRPDPREAL---- 4653 Query: 3459 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3518 RA ++K G+ L+G V +++ + G + Sbjct: 4654 ---RAATMEVKVGR---------------LRGRA-------------VPVWDVLASGYVS 4682 Query: 3519 ATTAALLLEAQAATGFLVDPVRNQRL--YVHEAVKAGVVGPELHEQLLSA-EKAVTGYRD 3575 LL A+ +G L P +RL + EA +A P+L + E G D Sbjct: 4683 GAAREELL-AEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGD 4741 Query: 3576 PYSGSTISLFQ---------AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAY 3626 SG + Q A ++ +R ++ G V V Sbjct: 4742 GDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQF----QGRPVSVWDVL 4797 Query: 3627 QRGYFSE-EMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEK 3685 Y SE + +LA + G D +L R +E+ E L + +G + Sbjct: 4798 FSSYLSEARRDELLAQHAAGALGLPD--------LVAVLTRVIEETEERLSKVSFRGLRR 4849 Query: 3686 AEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADF 3745 V ++++T ET D+ G T +L EV + D + Sbjct: 4850 Q--VSASELHTSGILG---PETLRDLAQG------TKTLQEVTEMDSVK----------- 4887 Query: 3746 QAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDY----VRRRLTAEDLFEARIISLETYN 3801 R + I + + K + RQ+ ++ Y V R TA L EA+ + + Sbjct: 4888 ---RYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVID 4944 Query: 3802 LLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3856 +R S+ EA+ A E L +V G P + Q +S++QA++K L+ E Sbjct: 4945 PVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREH 5004 Query: 3857 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQT 3916 LLEAQ ATG ++DPV R+ VD A R+G E++ L G+ DP T + Sbjct: 5005 GIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHEN 5064 Query: 3917 ISLFQAMKKELIPTEEALRLLDAQL 3941 ++ Q +++ + E L L L Sbjct: 5065 LTYLQLLQRATLDPETGLLFLSLSL 5089 Score = 347 bits (889), Expect = 2e-94 Identities = 202/360 (56%), Positives = 242/360 (67%), Gaps = 25/360 (6%) Query: 2671 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730 + +++ Q E E Q A+ ARR+ E+ +R E+Q+ + Q R + Sbjct: 4746 RSQREGQGEGETQEAAAAAAAARRQ----EQTLRDATMEVQRGQFQGRPVSVWDVLFSSY 4801 Query: 2731 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP---EHSFDGLR 2787 L E A +E+ A A LP+ L E E + SF GLR Sbjct: 4802 LSE-------------ARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 4848 Query: 2788 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN--- 2844 R+VSA L +GIL E L+ LAQG T+ E+ + V+ YL+G S IAG+L+ A + Sbjct: 4849 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 4908 Query: 2845 --EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHH 2902 EK+S+Y A+ + +L PGTAL+LLEAQAA+GF++DPVRN RL+V EAV GVVG E+ Sbjct: 4909 RQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQE 4968 Query: 2903 KLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2962 KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVP Sbjct: 4969 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVP 5028 Query: 2963 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLT 3022 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLL+R DPETGL L L+ Sbjct: 5029 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLS 5088 Score = 254 bits (648), Expect = 2e-66 Identities = 137/307 (44%), Positives = 206/307 (67%), Gaps = 8/307 (2%) Query: 3715 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3774 G G +S+W+V+ S + E +R +L+A AG + ++ ++ +IE+TE + Sbjct: 4784 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETE--ERLSK 4841 Query: 3775 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3834 S+ +RR+++A +L + I+ ET L +GT++L+E E +S YL GT +AGV + Sbjct: 4842 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4901 Query: 3835 P-----GSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGL 3889 P G ++ +SIYQA+ KG+L A +LLEAQAATGF++DPV+ RL+V+EAV G+ Sbjct: 4902 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4961 Query: 3890 VGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDP 3949 VG E+ ++LLSAERAVTGY DPYT Q ISLFQAM+K+LI E +RLL+AQ+ATGG++DP Sbjct: 4962 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 5021 Query: 3950 RLGFHLPLEVAYQRGYLNKDTHDQLSEPS-EVRSYVDPSTDERLSYTQLLRRCRRDDGTG 4008 +P++VAY+RGY +++ + L++PS + + + DP+T E L+Y QLL+R D TG Sbjct: 5022 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETG 5081 Query: 4009 QLLLPLS 4015 L L LS Sbjct: 5082 LLFLSLS 5088 Score = 177 bits (449), Expect = 2e-43 Identities = 132/409 (32%), Positives = 206/409 (50%), Gaps = 15/409 (3%) Query: 3160 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3219 A IAGV++E +GQ S+Y A+++ LLP+ + ALLEAQA TG ++D A L V +A+ Sbjct: 40 ARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKAL 99 Query: 3220 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3279 + GLVG E EKLL+AE+A TGY DPY G+ ++LFQA+ K ++ R G L+ QL+TGG Sbjct: 100 QQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGG 159 Query: 3280 IVDPSKSHRVPLDVACARGCLDEETSRALS--APRADAKAYSDPSTGEPATYGELQQRCR 3337 +VDP++ V + AC +G LD ET LS P + +P+T E TY +L +RC Sbjct: 160 LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERCV 219 Query: 3338 PDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSE 3397 +GL+LLPL +EL ++ V+ G +GR V +E Sbjct: 220 RAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQ---GLREGRLAAVDVSARAE 276 Query: 3398 YFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLAS 3457 +R++ G +V V+ + + E L G P+ ++ Sbjct: 277 ----------VRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATH 326 Query: 3458 GVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLL 3517 ++ ++L + L LL + G + + ++ +++AM++GL+ Sbjct: 327 TLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLV 386 Query: 3518 RATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSA 3566 A LL+AQ ATG LV P R RL + A++ G + + QL A Sbjct: 387 DRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQA 435 Score = 107 bits (267), Expect = 3e-22 Identities = 73/212 (34%), Positives = 111/212 (52%), Gaps = 5/212 (2%) Query: 4402 TQLASWSDPTEETGPVAGIL-----DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG 4456 T++ S E T +AG+L EK+SI +AM + ++ T LLEAQA TG Sbjct: 4347 TEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATG 4406 Query: 4457 GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWL 4516 +IDP R V +AV G+V + +++ A++A G+ DP T ++S QA++K + Sbjct: 4407 FVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLI 4466 Query: 4517 YYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPK 4576 E G R LE Q TGG+I+P RVP+D A +RG D + L D +K P Sbjct: 4467 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 4526 Query: 4577 TKLKISYKDALDRSMVEEGTGLRLLEAAAQST 4608 T ++Y L R + + TGL +L+ A + + Sbjct: 4527 THENLTYVQLLRRCVPDPDTGLYMLQLAGRGS 4558 Score = 107 bits (266), Expect = 4e-22 Identities = 73/210 (34%), Positives = 109/210 (51%), Gaps = 5/210 (2%) Query: 4402 TQLASWSDPTEETGPVAGIL-----DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG 4456 T++ S E T +AG+L EK+SI +AM + ++ T LLEAQA TG Sbjct: 4881 TEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATG 4940 Query: 4457 GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWL 4516 +IDP R V +AV G+V + +++ A++A G+ DP T ++S QA++K + Sbjct: 4941 FVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLI 5000 Query: 4517 YYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPK 4576 E G R LE Q TGG+I+P RVP+D A +RG D + L D +K P Sbjct: 5001 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 5060 Query: 4577 TKLKISYKDALDRSMVEEGTGLRLLEAAAQ 4606 T ++Y L R+ ++ TGL L + Q Sbjct: 5061 THENLTYLQLLQRATLDPETGLLFLSLSLQ 5090 Score = 105 bits (261), Expect = 1e-21 Identities = 69/217 (31%), Positives = 114/217 (52%), Gaps = 3/217 (1%) Query: 4388 GSSSSYPIS-PAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQ 4446 G++S+ S P L + + P + +AG+ + + S+ AM + L+ GQ Sbjct: 13 GTNSTEQASVPRAMAATLGAGTPPRPQARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQ 72 Query: 4447 RLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMS 4506 LLEAQA TGG++D + G+ PV+ A+ +GLV + +++ A++A G+ DP K++ Sbjct: 73 ALLEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATTGYPDPYGGEKLA 132 Query: 4507 AAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDV- 4565 QA+ K + GQ +LEVQ TGGL++P V + A +G +D T KL ++ Sbjct: 133 LFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSELE 192 Query: 4566 -GAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4601 G P T +++Y L+R + G+GL LL Sbjct: 193 PGTGDLRFLNPNTLERLTYHQLLERCVRAPGSGLALL 229 Score = 70.5 bits (171), Expect = 4e-11 Identities = 61/227 (26%), Positives = 102/227 (44%), Gaps = 17/227 (7%) Query: 4077 VDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPE 4136 ++ T+ERLS + +G+ R +A EL + + + T++E M V Sbjct: 4832 IEETEERLS--KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRY 4889 Query: 4137 FKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESH 4196 + A V P + +S++QAM KG++ + LLEAQ ATG +IDP + Sbjct: 4890 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 4949 Query: 4197 RLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLL 4256 RL VE A G+ E+ E L G+ DP T + ++ Q M++ + + G+ LL Sbjct: 4950 RLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 5009 Query: 4257 PLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQ 4303 E + ++ ++DP + V AYR+G D + Sbjct: 5010 -------EAQIATGG--------VIDPVHSHRVPVDVAYRRGYFDEE 5041 Score = 60.8 bits (146), Expect = 3e-08 Identities = 32/119 (26%), Positives = 61/119 (51%) Query: 2829 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2888 L ++ G T +++S++ A+Q+ L+ + LLEAQ A+G ++DPV + R+ V+ Sbjct: 4971 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 5030 Query: 2889 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2947 A + G E++ L G+ DP T + ++ Q +Q+ + E G+ L + Sbjct: 5031 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089 Score = 47.0 bits (110), Expect = 4e-04 Identities = 37/167 (22%), Positives = 73/167 (43%) Query: 4420 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4479 ++D ++S+ EA+ +V ++LL A+ G DP TG++ + A+ K L+ Sbjct: 4408 VIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIV 4467 Query: 4480 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4539 + R+ AQ A G DP ++ A ++G+ E + + T G +P+T Sbjct: 4468 REHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNT 4527 Query: 4540 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDA 4586 + + L+R D T + + + +L+ + +DA Sbjct: 4528 HENLTYVQLLRRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDA 4574 >gi|58530842 desmoplakin isoform II [Homo sapiens] Length = 2272 Score = 964 bits (2491), Expect = 0.0 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%) Query: 3777 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3836 +D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG Sbjct: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425 Query: 3837 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3896 ++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ + Sbjct: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485 Query: 3897 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3956 ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP Sbjct: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545 Query: 3957 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 4015 +VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL + Sbjct: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605 Query: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075 R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+ Sbjct: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664 Query: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135 + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG Sbjct: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724 Query: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195 EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES Sbjct: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784 Query: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255 HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL Sbjct: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844 Query: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315 LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW Sbjct: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904 Query: 4316 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4375 EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S Sbjct: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964 Query: 4376 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4421 G S S G SSS + +S + +S+SD EE+ P+A I Sbjct: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024 Query: 4422 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4481 DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+ Sbjct: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084 Query: 4482 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4541 M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G Sbjct: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144 Query: 4542 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4601 R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL Sbjct: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204 Query: 4602 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4653 EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S + Sbjct: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264 Query: 4654 FSSSS 4658 FSSSS Sbjct: 2265 FSSSS 2269 Score = 597 bits (1538), Expect = e-169 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%) Query: 545 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 604 C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P Sbjct: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135 Query: 605 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 661 + +R+ +L E++ A L ++ P + A + Q ++ T Sbjct: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187 Query: 662 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 721 + L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S Sbjct: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246 Query: 722 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 781 + +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW Sbjct: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298 Query: 782 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 841 SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW Sbjct: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358 Query: 842 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 901 SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + + Sbjct: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418 Query: 902 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 961 ++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK Sbjct: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478 Query: 962 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 1021 GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+ Sbjct: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538 Query: 1022 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1081 QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ + Sbjct: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598 Query: 1082 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1121 FG +D+ + ++ HYQ L+ L Q ++ CQ Sbjct: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658 Query: 1122 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1171 + EL+ IR Q+E CE R + LPL D+ + +I E + Q + Sbjct: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715 Query: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231 + +A + + + +LA S L++E+ KLE + ++ YL L T+ + Sbjct: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773 Query: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291 ++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+ Sbjct: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833 Query: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1351 AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+ Sbjct: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893 Query: 1352 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1411 + WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+ Sbjct: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953 Query: 1412 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470 N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y Sbjct: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013 Query: 1471 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1528 +F+SE L+ +E+ + + + + EE RLA + + + + + + Q K QAE Sbjct: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072 Query: 1529 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1588 + + EE+ R +A +D + K+++ + Q+++ +E +I + E +R R +E Sbjct: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129 Query: 1589 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1648 + + + ++ R + E + L + E+E ++ + E ERLR +Q+E RKR Sbjct: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186 Query: 1649 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1708 + E ELA E+ + + +Q E L ++ + E+ + R ++++ L A+ Sbjct: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241 Query: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1767 + EAE + K+ EK Q++ L + ++ +EEA R+ + + E +ER + E Sbjct: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299 Query: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827 +ER Q + + E + +++ +Q E E+ + + E + R+ Q E Sbjct: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358 Query: 1828 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1882 E ++ + + +G ++ A + +L +T +G++ + + E+ R A + Sbjct: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418 Query: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1934 + + + V A+ + L+ + E + LEA+A R Sbjct: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466 Query: 1935 ELAEEAARLRALAEEAKRQRQLAEEDA 1961 +L ++A R L + RQ+ A E A Sbjct: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493 Score = 419 bits (1078), Expect = e-116 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%) Query: 3073 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3128 +Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R Sbjct: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318 Query: 3129 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3185 RE QL+ ERS R E+D +R+ G++ E +++ L+K + Sbjct: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376 Query: 3186 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3245 A+ L E Q +D + +V+E V E L A P Sbjct: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426 Query: 3246 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3305 + SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D + Sbjct: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484 Query: 3306 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3349 + + A + DP +G+ + E ++ D+ TG+ LL L Sbjct: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544 Query: 3350 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3406 + A AR +LY L +K V+ PV K V + E Sbjct: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589 Query: 3407 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3466 + +E +L+ V++ +SF G+R PV +EL+ SG+L + Sbjct: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635 Query: 3467 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3526 +L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL Sbjct: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693 Query: 3527 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3586 EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ Sbjct: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753 Query: 3587 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3646 AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT Sbjct: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813 Query: 3647 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3706 KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R + Sbjct: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871 Query: 3707 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3758 + + MS+ E + LI E +L +++ +T R++++ Sbjct: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922 Query: 3759 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3789 I + I+K + R + G S ++ ++D+ Sbjct: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982 Query: 3790 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3842 F ++I ++ + L + S + LE S +A ++ + + +S Sbjct: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033 Query: 3843 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3902 I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+ Sbjct: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093 Query: 3903 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3962 +A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A + Sbjct: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153 Query: 3963 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 4021 +G+++ +L + S + P T ++SY + R +D TG L L +A ++ Sbjct: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210 Query: 4022 FRGLRKQITM 4031 +GL M Sbjct: 2211 SKGLPSPYNM 2220 Score = 417 bits (1072), Expect = e-115 Identities = 363/1343 (27%), Positives = 649/1343 (48%), Gaps = 181/1343 (13%) Query: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441 A + A L+ R D RFL E + ++ + + ++ V +E R E+ + Sbjct: 997 ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055 Query: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2501 + L + + K + + Q +L A E L++Q EL + A++ + ++L E+ Sbjct: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114 Query: 2502 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561 +E E++R+ + ++ K ++ +A+ + + E +G + +E A Sbjct: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164 Query: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2621 +EK ++ L + Q+ + R RE EL + ++Q+ K++ Q VQ Sbjct: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211 Query: 2622 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2681 E++SLL + + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E Sbjct: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257 Query: 2682 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2741 +Q++ + + + + EE +R+ + E ++ E+++ L E +RL+ +++ +EE+ Sbjct: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313 Query: 2742 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2787 R L S T SQ+ ++ + R G E + E FDGLR Sbjct: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373 Query: 2788 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2847 +KV+A +L E ++ L +L +G +V+E+A +++ +L+G SIAG + EK Sbjct: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430 Query: 2848 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2907 S+ A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+ ++ + ++ +A Sbjct: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490 Query: 2908 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2967 E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S +P DVA Sbjct: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550 Query: 2968 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 3027 RG D ++ R L DP D K F DP T + ++Y+QL ERC +P TGL LL + Sbjct: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604 Query: 3028 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 3085 +K ++S FQG + VT+ E+++S R + + +G Sbjct: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640 Query: 3086 RITVEKIIKII---------ITVVEEQEQKGRL-CFEGLR-SLV---PAAELLESR---- 3127 +I+ +++ + I I + + K +L +E ++ LV A ELLE++ Sbjct: 1641 QISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATG 1700 Query: 3128 -VIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLL 3186 ++D +L E R + ++ + L + G E G +S++ A+ K+L+ Sbjct: 1701 FIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELI 1760 Query: 3187 PSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPY 3246 + LLEAQ TG IIDP S RL VD A + G E E L G+ DP Sbjct: 1761 EKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPN 1820 Query: 3247 TGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSR 3306 T ++++ Q ++ + E GL LL + + K+ V +D ET++ Sbjct: 1821 TEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV----IVDPETNK 1876 Query: 3307 ALSAPRADAKAYSDPSTGEPATYGEL-QQRCRPDQLTGLSLLPLSEKAARARQEELYSEL 3365 +S A K D T+ EL +Q C +++T + S+ + R L Sbjct: 1877 EMSVQEAYKKGLIDYE-----TFKELCEQECEWEEIT----ITGSDGSTRV-------VL 1920 Query: 3366 QARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKIL 3425 R+T + ++ + KG L+ ++F Q+R+G +++ + ++ Sbjct: 1921 VDRKTGSQYDIQDAID--KG-------LVDRKFFD---------QYRSGSLSLTQFADMI 1962 Query: 3426 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3485 L+ V S + SGV S F + +V +S + SVR Sbjct: 1963 ------------------SLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSVR 2001 Query: 3486 TL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFL 3535 L L+ S +A I+ + EK+SI E + RG++ + T LLEAQA TG + Sbjct: 2002 NLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGI 2061 Query: 3536 VDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLR 3595 + P Q+L + +AV GV+ ++ +L A+KA G+ +S +A+++ + Sbjct: 2062 IHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPY 2121 Query: 3596 QHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTH 3655 + G R LE Q TGG++DP R+ + A ++G+ + L D S K P T Sbjct: 2122 EAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTK 2181 Query: 3656 ENLTYRQLLERCVEDPETGLRLL 3678 ++Y+ + R + + TGLRLL Sbjct: 2182 LKISYKDAINRSMVEDITGLRLL 2204 Score = 372 bits (956), Expect = e-102 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%) Query: 2782 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2841 SF G+R+ V+ L ++GIL + L G + DE+ R ++ +LQG S IAG+ + Sbjct: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667 Query: 2842 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2901 T +KL +Y A++ L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E Sbjct: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727 Query: 2902 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2961 KLLSAERAVTGY DP TG ISLFQAM K LI + HGIRLLEAQIATGG+IDP SHR+ Sbjct: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787 Query: 2962 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 3021 PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL Sbjct: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847 Query: 3022 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 3065 +K + +V D E ++ ++K + K + WE I Sbjct: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907 Query: 3066 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 3117 R L+ + + ++ I ++ +Q + G L L++ Sbjct: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967 Query: 3118 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3167 V + + S V D +++ + SV ++ + +VR L ++ IA ++ Sbjct: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024 Query: 3168 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3227 E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ + Sbjct: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084 Query: 3228 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3287 +L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP Sbjct: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144 Query: 3288 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3347 R+ + A +G +D ++ L + AK + P T +Y + R + +TGL LL Sbjct: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204 Query: 3348 PLSEKAAR 3355 + +++ Sbjct: 2205 EAASVSSK 2212 Score = 259 bits (663), Expect = 3e-68 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%) Query: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075 D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG Sbjct: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422 Query: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135 + KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++ Sbjct: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481 Query: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195 + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S Sbjct: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541 Query: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255 LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L Sbjct: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601 Query: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315 L + ++++ S +R + ++V E G++ T EL + + Sbjct: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644 Query: 4316 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4371 +E+ D + S I + + ++ I +A+ L+ R GT + Sbjct: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691 Query: 4372 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4428 +L A GF S+ P+ A R + V G D ET Sbjct: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748 Query: 4429 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4488 +S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++ Sbjct: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808 Query: 4489 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4533 GF DP T+ ++ Q ++ E G L + Q T Sbjct: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868 Query: 4534 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4580 +++P+T + + EA ++G +D T ++L + G+ L KT + Sbjct: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928 Query: 4581 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4640 +DA+D+ +V+ + + T+ +G G+++ +G + SR Sbjct: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988 Query: 4641 GS---FDATGSGFSMTFSSSSYSSS 4662 S S ++T SSS+S + Sbjct: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013 Score = 111 bits (278), Expect = 1e-23 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%) Query: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1909 E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A Sbjct: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077 Query: 1910 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1966 EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+ Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137 Query: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026 + +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+ Sbjct: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197 Query: 2027 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 2083 I+E + Q+ + +S L + K L +D R +R LE Sbjct: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235 Query: 2084 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 2143 EL R +S E R K++ E E + + + + + EE ++K + E++ R++ + Sbjct: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295 Query: 2144 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199 E+ERL+A++ E RR E + +E+ QL+ + Q+ + + + ++ + Sbjct: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355 Query: 2200 QELQQTLQQEQSVLDQLRGEAEA 2222 E + T+ + V D LR + A Sbjct: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378 Score = 99.8 bits (247), Expect = 6e-20 Identities = 62/210 (29%), Positives = 109/210 (51%) Query: 2829 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2888 L+ S IA + EK+S+ ++R ++ T LLEAQA +G ++ P ++L++ Sbjct: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073 Query: 2889 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2948 +AV +GV+ ++ +L A++A G++ +++S +A+++ + E G R LE Q Sbjct: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133 Query: 2949 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 3008 TGG++DP R+ + A R+G+ D + L D S K P T ++Y + R Sbjct: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193 Query: 3009 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 3038 + + TGL LL ++KG Y S A Sbjct: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223 >gi|58530840 desmoplakin isoform I [Homo sapiens] Length = 2871 Score = 964 bits (2491), Expect = 0.0 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%) Query: 3777 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3836 +D +R+++TA L+E ++I T + L +G +S+ E A +L G GS+AG Sbjct: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024 Query: 3837 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3896 ++ S+ +A +K L+S E +LLEAQAATG ++DP + E+LTVD A+ + L+ + Sbjct: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084 Query: 3897 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3956 ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI E +RLL+AQ+A+GG+VDP LP Sbjct: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144 Query: 3957 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 4015 +VA RG +++D + L++P + +++VDP T +++SY QL RCR + TG LLL + Sbjct: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204 Query: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075 R ++F+G+R+ +T+ ELV S ++ +T +L G S +EV + ++ FL+G+SCIAG+ Sbjct: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263 Query: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135 + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+ L+L VEEA + G+VG Sbjct: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323 Query: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195 EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES Sbjct: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383 Query: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255 HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL Sbjct: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443 Query: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315 LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW Sbjct: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503 Query: 4316 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4375 EEITI+ SDG + +++DR++G QYDI DAI K L+DR DQYR+G+LS+T+FADM+S Sbjct: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563 Query: 4376 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4421 G S S G SSS + +S + +S+SD EE+ P+A I Sbjct: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623 Query: 4422 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4481 DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++ + DAV++G++D+ Sbjct: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683 Query: 4482 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4541 M R+ AQKAF GFE + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+ G Sbjct: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743 Query: 4542 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4601 R+ +EA+++G +D R AQ+L+D +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL Sbjct: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803 Query: 4602 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4653 EAA+ S+KG SPY++S SGS +GSR+GSR+GSR+GSRRGSFDATG+ +S + Sbjct: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863 Query: 4654 FSSSS 4658 FSSSS Sbjct: 2864 FSSSS 2868 Score = 862 bits (2228), Expect = 0.0 Identities = 745/2950 (25%), Positives = 1363/2950 (46%), Gaps = 355/2950 (12%) Query: 545 CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 604 C + L +A+ ++Q +++ G R+ E++ +A+ + +L + ++ ++ P Sbjct: 78 CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135 Query: 605 EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 661 + +R+ +L E++ A L ++ P + A + Q ++ T Sbjct: 136 DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187 Query: 662 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 721 + L W+ + + +D WGVDL SVE + SHRG+H SI ++R ++++ ++D + S Sbjct: 188 TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246 Query: 722 ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 781 + +L+ +Y LL +S R+ L L + + A ++E+MW+N+ EEEE+ +DW Sbjct: 247 --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298 Query: 782 SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 841 SD+NTN+ K+E++S M +LE+KEK++ +L+ D+L+ HPA +E++ LQTQW Sbjct: 299 SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358 Query: 842 SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 901 SW+LQ+ CI+ HLKENAAYFQFF + + E L+ LQ+++R+KY CD++ + L + + Sbjct: 359 SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418 Query: 902 QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 961 ++ + E+E++ EYK + L ++K +VQLKPR+P + + L A+CDYKQ + VHK Sbjct: 419 KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478 Query: 962 GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 1021 GDEC L + S W V G + VPSV ++PPPN A + ++E ++A++ LW+ Sbjct: 479 GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538 Query: 1022 QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 1081 QL+++MKSL++W D++ IR+ ++A +T++ E+ + + LELHYQ F+R+SQ + Sbjct: 539 QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598 Query: 1082 GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 1121 FG +D+ + ++ HYQ L+ L Q ++ CQ Sbjct: 599 MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658 Query: 1122 ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1171 + EL+ IR Q+E CE R + LPL D+ + +I E + Q + Sbjct: 659 RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715 Query: 1172 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231 + +A + + + +LA S L++E+ KLE + ++ YL L T+ + Sbjct: 716 --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773 Query: 1232 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1291 ++ E++L+ +E +L E + V L ++EA + LKK++ ++ ++ EL+ Sbjct: 774 LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833 Query: 1292 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1351 AQ++ + Q++ D+++ ++ E+V QL +RWQ + Q D R +LE+ +QLR YR+ Sbjct: 834 KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893 Query: 1352 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1411 + WL DA+RRQ+ +++M DS V L +++ L EI +K EE Q+ A+ Sbjct: 894 NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953 Query: 1412 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1470 N+IKDYELQL +Y + LE + + P K+ +QS S ++QE D+ Y EL T + Y Sbjct: 954 CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013 Query: 1471 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1516 +F+SE L+ +EEE RLA +E + ++ L+K Q + ++ Sbjct: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073 Query: 1517 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1560 A + K QAE + K +Q + E++ R D +++++S+++ Sbjct: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133 Query: 1561 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1620 Q Q ++ + KARQ E +E + +L+ E +++ E E++ LR + Sbjct: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179 Query: 1621 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1677 E +KR+ + E ++R +E + K + E+ + E +E + Sbjct: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234 Query: 1678 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1732 LR Q + R R + E R + A E +R+ E LQ K + +K LE Sbjct: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294 Query: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1791 L++ + Q E+ R Q EA + ++ +E+ER + + E + R + E E+++ Sbjct: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351 Query: 1792 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1851 ++ E K + E E Q Q+ E++ R + ++ + +E Sbjct: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408 Query: 1852 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911 + RL+ Q + + +EE++ + + + +Q++Q+LE EL +V ++ R Sbjct: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459 Query: 1912 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1970 EE S + KQ L+ A ++ +E RL+ L ++ R+ E++ AR QR + + Sbjct: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513 Query: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 2030 + +A TE LK +E E RLR E + +R ++ + + ++E Sbjct: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565 Query: 2031 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 2087 Q +K + EL R K + +R+++EEE+ ++ S ++ A L +L + Sbjct: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624 Query: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 2140 ++ +ED LR + R++Q EE RR E +++ L E+E+ +Q Sbjct: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684 Query: 2141 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2199 +KA ++ L E RL+ E + L L +E RL+ ++ + + Sbjct: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744 Query: 2200 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2247 + EL+ LQ + Q +++ L+ E E R+ E+ ++ ++A +S+ Q Sbjct: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804 Query: 2248 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2307 + + ++S + + Q +A ++L E E R +A R KQ + E ++ Sbjct: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860 Query: 2308 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2366 + Q Q ++ E+ + + + E+++ +KN L E++RL+AE R R ++E+ Sbjct: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919 Query: 2367 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2423 S R +L ++R + E L R + R Q E E ++ + R V Sbjct: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976 Query: 2424 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2483 A QL E L + L +K+LK K Sbjct: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998 Query: 2484 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2543 + +++A E Q F R + + ++ + + K + E R + + E Sbjct: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048 Query: 2544 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2601 + G + HR E T + ++ +Q + AE+ + K Sbjct: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108 Query: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661 EA L E L E Q + +S+ F+ ++ A L ++ Sbjct: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158 Query: 2662 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2721 ++ L + + Q+ ++ ++ V+ ++ R + E G L L Q+R Sbjct: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208 Query: 2722 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2779 Q +R+ + + E L S E+ + Q++ + +D L G + A Sbjct: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261 Query: 2780 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2839 G+ + + Q+L GI A ++ + G T EL L+ +++ ++ Sbjct: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302 Query: 2840 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2899 +N +L V A +R L+ LL A+ A DP +++ +A+ + ++ Sbjct: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362 Query: 2900 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2959 +LL A+ A G DP ++ + A ++G Sbjct: 2363 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG--------------------------- 2395 Query: 2960 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 3019 YF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL Sbjct: 2396 -----------YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444 Query: 3020 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 3063 PL +K + +V D E ++ ++K + K + WE Sbjct: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504 Query: 3064 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 3115 I R L+ + + ++ I ++ +Q + G L L+ Sbjct: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564 Query: 3116 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3165 + V + + S V D +++ + SV ++ + +VR L ++ IA Sbjct: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621 Query: 3166 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3225 ++ E +K+SI +++ ++ S LLEAQA TG II P T +L++ +AV G++ Sbjct: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681 Query: 3226 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3285 + +L A+KA G+ + +S +A+K+ +P E G R L+ Q TGG+VDP Sbjct: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741 Query: 3286 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3345 R+ + A +G +D ++ L + AK + P T +Y + R + +TGL Sbjct: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801 Query: 3346 LLPLSEKAAR 3355 LL + +++ Sbjct: 2802 LLEAASVSSK 2811 Score = 544 bits (1401), Expect = e-154 Identities = 502/1978 (25%), Positives = 899/1978 (45%), Gaps = 304/1978 (15%) Query: 1851 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1909 E+++ + + + ++LEEEL RL R+A + K + L+ L K +AE A A Sbjct: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077 Query: 1910 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1966 EE R + +KQ L+ G+ +EL E+ RL E+ KR+R+ E+ +Q+ Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137 Query: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026 + +++ + K E+E A+KEKE E ERLR L ++E ++R E + A+ + Sbjct: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197 Query: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086 E ++ LR ++E+ K +++ Q+ E++ L+ ++ + +L+ E+ Sbjct: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254 Query: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146 R+ + + +AE A +Q+ +E ++++ E +++ + E + K +LE Sbjct: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314 Query: 2147 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2190 E + ++ K +E RL+ ++E+ R+ + E ++ R +E+ Sbjct: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374 Query: 2191 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2224 H +Q++E + L+ TL Q L ++ + + + Sbjct: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434 Query: 2225 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283 E + + Q E E Q ++ + EE+ R KQS ++ A+ E+L++ ++E Sbjct: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494 Query: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343 R E R Q +++K A +T+ + EQELT LR+ E ++ + D Sbjct: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553 Query: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403 +++ R + E Q+ +VEEEL ++ E S + ++E E + +R L Sbjct: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605 Query: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463 +E+A K+ + ++ + S+ +++ +E+DL QQR + + L+EK + +E RL Sbjct: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658 Query: 2464 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523 +E E L++Q L QEQ + +Q + FQ+ +E + + E E ERL+ Sbjct: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707 Query: 2524 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2583 +++ EE+ + R + +++ + R+E + + T+++ L Q Q S++ Sbjct: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764 Query: 2584 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2643 L+ I +L+RE+E L+QE + Q ++ E QE Q TQ +Q E++SLL + Sbjct: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819 Query: 2644 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2703 + +EQ+KA+L++L +DE+ +A+ E + R +Q++E E+Q++ + + + + EE + Sbjct: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878 Query: 2704 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2763 R+ + E ++ E+++ L E +RL+ +++ +EE+ R L S T SQ+ Sbjct: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL------ 1928 Query: 2764 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2823 E E S R + +L++ S E Q + TVD Sbjct: 1929 --------------ETERS----RYQREIDKLRQRPYGSHRETQ--TECEWTVD------ 1962 Query: 2824 DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNR 2883 KL V+ L++++ TA+ L E Q LD + Sbjct: 1963 --------------------TSKL-VFDGLRKKV----TAMQLYECQLIDKTTLDKLLKG 1997 Query: 2884 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLL 2943 + +V E V E+ L A P ++ SL +A +K LI E + LL Sbjct: 1998 KKSVEE------VASEIQPFLRGAGSIAGASASPK--EKYSLVEAKRKKLISPESTVMLL 2049 Query: 2944 EAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQ 3003 EAQ ATGG+IDP + ++ VD A R D + + + GF DP + + ++ + Sbjct: 2050 EAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSE 2109 Query: 3004 LLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWE 3063 +++ + D ETG+ LL + A GG + +S VF V+ G Sbjct: 2110 AIKKNLIDRETGMRLLEA--QIASGGVVDPVNS----VFLPKDVALARGL---------- 2153 Query: 3064 IINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQE---------------QKGR 3108 I Y + RD + F V+ + K ++ V+ +E QK Sbjct: 2154 IDRDLYRSLNDPRDSQKNF------VDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRS 2207 Query: 3109 LCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWL 3168 + F+G+R V EL++S ++ +L+ G+ S +V E ++ L+G++ IAG++ Sbjct: 2208 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE--RIKDFLQGSSCIAGIYN 2265 Query: 3169 EEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEF 3228 E QKL IY A+K L+ A+ LLEAQA TG I+DP ++ RL V+EA + GLVG EF Sbjct: 2266 ETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEF 2325 Query: 3229 HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHR 3288 EKLLSAE+AVTGY DP TG +SLFQA+ K LI + G+RLL+AQ++TGGI+DP +SHR Sbjct: 2326 KEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHR 2385 Query: 3289 VPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP 3348 +P+D+A RG +EE S LS P D K + DP+T E TY +L++RC D+ TGL LLP Sbjct: 2386 LPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLP 2445 Query: 3349 LSEKAARARQE---------------ELYSELQARETFEKTPV----------------E 3377 L EK + + E E+ +E ++K + E Sbjct: 2446 LKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEE 2505 Query: 3378 VPVGGFKG--RTVTVWELISSEYFTAEQ------RQELLRQFRTGKVTVEKVIKIL---- 3425 + + G G R V V S+Y + ++ Q+R+G +++ + ++ Sbjct: 2506 ITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKN 2565 Query: 3426 ------------------------ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLS 3461 ++ + + ++R + S + S +A+ + Sbjct: 2566 GVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA-IFD 2624 Query: 3462 RAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATT 3521 E++ + + + + + + LL+ C GI T +K+S+ +A+ +G++ Sbjct: 2625 TENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDM 2684 Query: 3522 AALLLEAQAA--------------------------------------TGFLVDPVRNQR 3543 A L AQ A TG LVDP + R Sbjct: 2685 ATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGR 2744 Query: 3544 LYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLE 3603 + EA++ G + ++L P + IS A+ + +V G+RLLE Sbjct: 2745 ISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLE 2804 Query: 3604 -AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3660 A +++ G+ P + P + R S +G FD + + +Y Sbjct: 2805 AASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSFDATGNSSYSY 2860 Score = 419 bits (1078), Expect = e-116 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%) Query: 3073 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 3128 +Q ++ L Q++T E+ I+ I + E+ E++ + L + +E R Sbjct: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917 Query: 3129 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3185 RE QL+ ERS R E+D +R+ G++ E +++ L+K + Sbjct: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975 Query: 3186 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3245 A+ L E Q +D + +V+E V E L A P Sbjct: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025 Query: 3246 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3305 + SL +A +K LI E + LL+AQ +TGGI+DP ++ ++ +D A AR +D + Sbjct: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083 Query: 3306 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3349 + + A + DP +G+ + E ++ D+ TG+ LL L Sbjct: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143 Query: 3350 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3406 + A AR +LY L +K V+ PV K V + E Sbjct: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188 Query: 3407 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3466 + +E +L+ V++ +SF G+R PV +EL+ SG+L + Sbjct: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234 Query: 3467 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3526 +L+ G+ + ++ E ++ LQGS C+AGIY E TK+K+ IYEAM+ GL+R TA LL Sbjct: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292 Query: 3527 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3586 EAQAATGF+VDPV N RL V EA K G+VG E E+LLSAE+AVTGY DP +G+ ISLFQ Sbjct: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352 Query: 3587 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3646 AM K L+ + HGIRLLEAQIATGGIIDP SHR+PVD+AY+RGYF+EE++ +L+DPSDDT Sbjct: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412 Query: 3647 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3706 KGFFDPNT ENLTY QL ERC++D ETGL LLPLK EK + V+T+Q T + R + Sbjct: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470 Query: 3707 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3758 + + MS+ E + LI E +L +++ +T R++++ Sbjct: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521 Query: 3759 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3789 I + I+K + R + G S ++ ++D+ Sbjct: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581 Query: 3790 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3842 F ++I ++ + L + S + LE S +A ++ + + +S Sbjct: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632 Query: 3843 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3902 I + +++G++ + + LLEAQA TG ++ P G++L++ +AV +G++ ++ RL A+ Sbjct: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692 Query: 3903 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3962 +A G+ ++ +S +A+K++ +P E R L+ Q TGG+VDP + + E A + Sbjct: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752 Query: 3963 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 4021 +G+++ +L + S + P T ++SY + R +D TG L L +A ++ Sbjct: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809 Query: 4022 FRGLRKQITM 4031 +GL M Sbjct: 2810 SKGLPSPYNM 2819 Score = 259 bits (663), Expect = 3e-68 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%) Query: 4016 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 4075 D KL F GLRK++T +L Q++D+ T +L +G S+EEV +Q FL G IAG Sbjct: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021 Query: 4076 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 4135 + KE+ S+ +A +K +I P + LLEAQAATG +IDP + KLTV+ A+ ++ Sbjct: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080 Query: 4136 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4195 + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP S Sbjct: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140 Query: 4196 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4255 LP +VA RGL D ++ L DP D K F DP T++ ++Y+QL ERC +P TGL L Sbjct: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200 Query: 4256 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4315 L + ++++ S +R + ++V E G++ T EL + + Sbjct: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243 Query: 4316 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4371 +E+ D + S I + + ++ I +A+ L+ R GT + Sbjct: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290 Query: 4372 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4428 +L A GF S+ P+ A R + V G D ET Sbjct: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347 Query: 4429 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4488 +S+ +AM++ L++ G RLLEAQ TGGIIDP R PV A +G ++ + + ++ Sbjct: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407 Query: 4489 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4533 GF DP T+ ++ Q ++ E G L + Q T Sbjct: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467 Query: 4534 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4580 +++P+T + + EA ++G +D T ++L + G+ L KT + Sbjct: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527 Query: 4581 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4640 +DA+D+ +V+ + + T+ +G G+++ +G + SR Sbjct: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587 Query: 4641 GS---FDATGSGFSMTFSSSSYSSS 4662 S S ++T SSS+S + Sbjct: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612 >gi|4502443 dystonin isoform 1e precursor [Homo sapiens] Length = 2649 Score = 921 bits (2380), Expect = 0.0 Identities = 596/2064 (28%), Positives = 1094/2064 (53%), Gaps = 117/2064 (5%) Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 Query: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106 Query: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1552 +++ ++ +E A + ++A L+ ++ ++ E + ++QK Sbjct: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154 Query: 1553 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1612 ++EEL ++R+++E E++ + R E ++R E E + R +LE R++ AE EL Sbjct: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214 Query: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1672 + +R EAEA++ +E R Q+++ + +R E L + + + ++K + + Sbjct: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274 Query: 1673 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732 + L R EE + ++Q E + A Q QVA + + + EL+++R K +++ + Sbjct: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329 Query: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792 +E + V + + RA + E +++AE EL++ + +E +AE+ ++ Sbjct: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385 Query: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852 + + +K +E +AR ++ + ELE++ Q +G +QQ ++L Sbjct: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445 Query: 1853 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1912 + + E+ Q+ L++ Q E + ++ +L+ E+ ++ Sbjct: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490 Query: 1913 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1970 + + +EK+ Q L ++ FR+ +E RL+ ++ ++ E+ + Q +AE+ Sbjct: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549 Query: 1971 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 2027 +K+ + E E LK+K E L R + +R++ E K Sbjct: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606 Query: 2028 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 2087 I++R L+ +D + Q + L ++ + E++ E+ A L E + Sbjct: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664 Query: 2088 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 2147 + + ++ + + E+ A++EE+RR E + ++Q +A ++E Sbjct: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711 Query: 2148 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2207 + KV++ L+ EQ + R++ L QE + K Q+ E+ ++K ++L ++ Sbjct: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEE-----FRKKMEKLMESKV 1766 Query: 2208 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2267 ++ + +R + + ++ A+E E + RQ L+Q E+ Q + Sbjct: 1767 ITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQ------LQQYREQMQQGQHM 1820 Query: 2268 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT- 2326 +K +K ++ A++ + E L+QK + +H+ Q QK ++ T Sbjct: 1821 EANHYQKCQKLEDELIAQKREVEN--LKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTF 1878 Query: 2327 --TLRLQLEETDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLK 2381 + ++E H L L Q Q EE + RV +E++ K + Sbjct: 1879 KPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRV-VEQIPK-E 1936 Query: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441 + + L +K+ +Q+ E ++ + L + E + +L+E + + Sbjct: 1937 VQFQPPGAPL---EKEKSQQCYSE------YFSQTSTELQITFDETNPITRLSEIEKIRD 1987 Query: 2442 RALAEKMLKEKMQ---AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2498 +AL + Q E ++ E+ + ++ + L+++K + Sbjct: 1988 QALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWML 2047 Query: 2499 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA---EEIGEKLH 2555 +G + + ++ L+ E E + + + + E Q R + + KL Sbjct: 2048 EGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLL 2107 Query: 2556 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA--------KLLQ 2607 Q ++ L E+Q+ + + A LE KEK+ + K++ Sbjct: 2108 DMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVA 2167 Query: 2608 LKSEEMQTVQQ---EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2664 L E Q + + +T +++ + L R R +E EKA + + + Sbjct: 2168 LAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSYSSKTLSV 2227 Query: 2665 QQLREEQQRQQQQMEQERQRLVAS 2688 Q E + +Q+ + + +AS Sbjct: 2228 FQAMENRMLDRQKGKHILEAQIAS 2251 Score = 414 bits (1064), Expect = e-114 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%) Query: 3956 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 4007 PLE+A + Y D H +++ + ++ V PS +E +L CR G Sbjct: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064 Query: 4008 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 4056 G + D + F+GLR +T +LV ++++D T QLR GL ++E Sbjct: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123 Query: 4057 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 4116 EV K L KFL + IAG+++++TKE++S A ++ II A LEAQAATG++IDP Sbjct: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183 Query: 4117 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4176 I G +VE+AV G+V PEF+ +LL AE+A GY YS K +S+FQAM+ ++ + G Sbjct: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241 Query: 4177 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4236 +LEAQIA+GG+IDP R+P E+A ++GL + + + L +PS +T+ F +PN ++ L Sbjct: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301 Query: 4237 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4296 Y +L+ C+ D ++ L P ER S+ + + R+ +VD +TG E++VYEA++ Sbjct: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357 Query: 4297 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4356 + LI+ YLELS Q+ +W+E S G M+ D ++G ++I++AI + ID++ + Sbjct: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417 Query: 4357 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4416 +Y+ G +++TE AD L +S V + L S P Sbjct: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447 Query: 4417 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4476 VAG T + E++S+ +A RNLVD IT R LEAQ TGGIIDP TG+++ V +A+++G Sbjct: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507 Query: 4477 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4536 LVD+ ++ + G P T MS +A+ + E G R LE QYLTGGLIE Sbjct: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567 Query: 4537 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4596 P R+ ++EALQ G +D A KL+D +Y + + CP+TK K++YK+AL+++ + T Sbjct: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627 Query: 4597 GLRLLEAAAQSTKGYYSPY 4615 GL+LLE + G S Y Sbjct: 2628 GLKLLEVSEPLMTGISSLY 2646 Score = 411 bits (1056), Expect = e-114 Identities = 537/2416 (22%), Positives = 1013/2416 (41%), Gaps = 334/2416 (13%) Query: 1175 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1234 K V R E E +L E + + + L+LT E++ L + Y + L T R Sbjct: 316 KNVHRAIEEFES--SLKEAKISEIQMTAPLKLTYA--EKLHRLESQYAKLLNTSRNQERH 371 Query: 1235 TQGAEE-VLRAHEEQL----KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1289 V RA E + KE + V E A K A+ + D + Sbjct: 372 LDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRE---LDQKEEN 428 Query: 1290 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1349 ++ QE+ E+L + + +E +R A + +W +L ++ +++ ++ Sbjct: 429 IKSVQEIAEQLLLENHPARLTIEAYR---AAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485 Query: 1350 ---RESADPLGAWLQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIERH 1398 +E+ D L L+DA +R+ + +S +E+L Q ++ + + Sbjct: 486 NDAKEATDYLRN-LKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGK 544 Query: 1399 GEKV-------EECQRFAKQYINAIKDY-ELQLVTYKAQLEPVASPAKKPKVQ----SGS 1446 + + +C I AI DY ++++ YK +A+ + + K + +G+ Sbjct: 545 AKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGN 604 Query: 1447 ESVI-----------QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1495 E+++ +E VDL + QY + + + E + + Sbjct: 605 EAMVPSVCFTVPPPNKEAVDLANRIEQ------QY-----QNVLTLWHESHINMKSVVSW 653 Query: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1555 + E++ + +A + ++ LQ R ++ + +E+ V + + Sbjct: 654 HYLINEIDRI--RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQL 711 Query: 1556 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1615 ++E+ +Q + +++ R+ + L I E +R +RL+LE E + ++ + Sbjct: 712 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISE-VRNIRLRLENCEDRL------IRQI 764 Query: 1616 RARAEEAEAQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674 R E + + + E E+L++++ E + + AA L++ Sbjct: 765 RTPLERDDLHESVFRITEQEKLKKEL--ERLKDDLGTITNKCEEFFSQAAASSSVPTLRS 822 Query: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734 + LQ + +++ + V + L+ Q +AEA ++ E+ A + Sbjct: 823 ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQ-AAEALVKLYETKLCEEEAVIADKNN 881 Query: 1735 EEHV--AVAQLREEAERRAQ---------QQAEA----------------ERAREEAERE 1767 E++ + Q R E + + Q Q+A+A + +E+A++ Sbjct: 882 IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941 Query: 1768 LERWQ---------LKANEALRLRLQ--------AEEVAQQKSLAQAEAEKQKEEAEREA 1810 +ERWQ L+ E + L+ ++ QQ Q + ++ + E + Sbjct: 942 VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1001 Query: 1811 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870 + ++ V + E+ + ++++ ++ AE + E + + RA + QQ+ ++ Sbjct: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDS--QQKSPVK 1059 Query: 1871 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SKARAEEES----RSTSEKS 1922 R+Q A Q+ +L + M + S R EEE + TSE Sbjct: 1060 RR--RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHG 1117 Query: 1923 K-----QRLEAEA-------GRFRELAEEAARLRA----LAEEAKRQRQLAEEDAARQRA 1966 QR +A G+ EL A L+ + EE + R+ AE + +Q+ Sbjct: 1118 AYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177 Query: 1967 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQ 2023 E + +K+ A EA + + E E ++EKEA E ER+R+L + +R +EE Sbjct: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237 Query: 2024 HKADIEERLAQLRKASD---------SELERQKGLVEDTLRQRRQVEEEILALKASFEKA 2074 + +EE R D ++LE+QK + + LR++R EEE+L L EK Sbjct: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKD 1297 Query: 2075 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 2134 A + ++ AE L+ K++ ELEA R+ R + ++ + Sbjct: 1298 LAFQKQV----------AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCR 1347 Query: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAF 2193 Q++ ++ E LK +V+E +AEQ+ R+L A Q ++ +EEKA Sbjct: 1348 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM-RELTYELNALQLEKTSSEEKARLL 1406 Query: 2194 AVQQKEQ---------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244 + E EL++ Q E+ QLR + +AEEA +A Sbjct: 1407 KDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK 1466 Query: 2245 RRQVEEAERL---KQSAEEQAQARAQAQAAAEK-----------LRKEAEQEAARRAQAE 2290 R E E L K + + +A A AEK R E E E + Q + Sbjct: 1467 RNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRK 1526 Query: 2291 QAALRQK---------QAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKN 2340 L+++ Q AE E + K Q L ++ + E L+ ++EE Q N Sbjct: 1527 SDHLKEQFEKSHEQLLQNIKAEKENNDKI--QRLNEELEKSNECAEMLKQKVEELTRQNN 1584 Query: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-----------EELSKLKARIEAENR 2389 +QR++AE+ ++ +++ ++++Q E L K + R Sbjct: 1585 ETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQR 1644 Query: 2390 ALILRDKD--NTQRFLQEEAEKMKQ-------VAEEAARLSVAAQEAARLRQLAEEDLAQ 2440 + ++D +Q + E +K Q +E L+ + ++ E+ + Sbjct: 1645 KIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQL 1704 Query: 2441 QRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQEDKEQMAQQLAE--- 2496 Q+A ++ L +++ VQ+ LK E ++ ++ L QE++ + ++ E+ +++ + Sbjct: 1705 QQAQVQE-LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLME 1763 Query: 2497 -------ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549 + G + + +Q A+ + + E+ R + E Q+ + Sbjct: 1764 SKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEAN 1823 Query: 2550 IGEKLHRTE---LATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKE-------- 2597 +K + E +A + +V L Q ++ Q ++ +H L+ I + K+ Sbjct: 1824 HYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFE 1883 Query: 2598 ----KLQQEAKLLQLKSEEMQTVQQEQLL---QETQALQQSFLSEKDSLLQRERFIEQEK 2650 + Q +L + + + LL QE Q L++ + + +E + Sbjct: 1884 MTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPG 1943 Query: 2651 AKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR--- 2704 A LE+ K+QQ E Q + Q+ + + + E + + +A R Sbjct: 1944 APLEK------EKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPV 1997 Query: 2705 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764 R Q+ ++E + +A+ Q +Q + + +EE A+ L Sbjct: 1998 RYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLK 2057 Query: 2765 NGRDALDGPAAEA-------------EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2811 G G E + E F GLR V+A++L EA +L +++L Sbjct: 2058 KGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRL 2117 Query: 2812 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2871 G TV+E+ ++ + +L +SIAGL L++T EK+S +A +R ++ AL LEAQA Sbjct: 2118 GLKTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQA 2175 Query: 2872 ASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2931 A+GF++DP+ + +V +AV +GVV PE +LL AE+A GY Y+ + +S+FQAM+ Sbjct: 2176 ATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMEN 2233 Query: 2932 GLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFF 2991 ++ R+ G +LEAQIA+GGVIDPV RVP ++A ++G + + + L +PS +T+ F Sbjct: 2234 RMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFP 2293 Query: 2992 DPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPF 3051 +PN + L Y +LL CV D E+ L P GE ++ + + V Sbjct: 2294 NPNNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK- 2345 Query: 3052 GKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCF 3111 G +T++E R +EK I + ++ ++ + K + F Sbjct: 2346 ---TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFF 2382 Query: 3112 E--------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRAL 3157 E GL + E +E ID+ L ++ Q G ++ ++A+ R Sbjct: 2383 ESYGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVP 2440 Query: 3158 RG--ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTV 3215 + + +AG WL +G+++S+ A +++L+ A+ LEAQ TG IIDP T + V Sbjct: 2441 KKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRV 2500 Query: 3216 DEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3275 EA+ GLV F ++L E +TG P T + +S+ +A+ +I +E G+R L+ Q Sbjct: 2501 AEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQY 2560 Query: 3276 STGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQR 3335 TGG+++P R+ ++ A G +D + L ++ + P T TY E ++ Sbjct: 2561 LTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEK 2620 Query: 3336 CRPDQLTGLSLLPLSE 3351 D TGL LL +SE Sbjct: 2621 ADFDFHTGLKLLEVSE 2636 Score = 262 bits (669), Expect = 7e-69 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%) Query: 3434 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3493 ++R + F GLR V A +L+ + +L EQL+ G TV+++ + ++ L + Sbjct: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138 Query: 3494 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3553 +AG+YLE TKEK+S A R ++ A LEAQAATGF++DP+ Q V +AV G Sbjct: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198 Query: 3554 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3613 VV PE +LL AEKA GY YS T+S+FQAM+ ++ RQ G +LEAQIA+GG+ID Sbjct: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256 Query: 3614 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3673 PV RVP ++A Q+G + + + L +PS +T+ F +PN + L Y +LL CV D E+ Sbjct: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316 Query: 3674 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3731 L P + V +T ++ + + GS ++++E Q + Sbjct: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359 Query: 3732 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3790 LI + +L +Q KE M + GL + Sbjct: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407 Query: 3791 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3846 E I +EG +L E A+S L VAG +L S + +S+ +A Sbjct: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465 Query: 3847 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3906 ++ L+ A LEAQ +TG ++DP+ G++ V EA+ +GLV +L E +T Sbjct: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525 Query: 3907 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3966 G P T + +S+ +A+ +I E +R L+ Q TGG+++P++ L +E A Q G + Sbjct: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585 Query: 3967 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 4016 + +L + S VR+ + P T +L+Y + L + D TG LL +S+ Sbjct: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636 Score = 260 bits (664), Expect = 3e-68 Identities = 169/550 (30%), Positives = 284/550 (51%), Gaps = 74/550 (13%) Query: 3780 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3839 +R +TA L EA+++ + T LR G +++ E + + +L S+AG+YL +++ Sbjct: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149 Query: 3840 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3899 +S A ++ ++ VA LEAQAATGF++DP+ G+ +V++AV KG+V PE RLL Sbjct: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209 Query: 3900 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3959 AE+A GY Y+ +T+S+FQAM+ ++ ++ +L+AQ+A+GG++DP G +P E+ Sbjct: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267 Query: 3960 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 4018 A Q+G LN L EP S R + +P+ + L Y++LLR C D + L P + R Sbjct: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326 Query: 4019 KLTFRGLRK-------------QITMEELVRSQVMDEATALQL----------------- 4048 ++ ++K ++T+ E + +++++ L+L Sbjct: 2327 NISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYG 2386 Query: 4049 ----------------------------------REGLTSIEEVTKNLQKFL----EGTS 4070 +EGL ++ E+ +L L + S Sbjct: 2387 HSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHS 2446 Query: 4071 CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM 4130 +AG ++ A+ ER+SV +A ++ ++ TA LEAQ +TG +IDP+ G K V EA+ Sbjct: 2447 PVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHR 2506 Query: 4131 GIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGII 4190 G+V F +L E +TG P + K++S+ +A+ +I K+ GIR LE Q TGG+I Sbjct: 2507 GLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLI 2566 Query: 4191 DPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQ 4250 +P+ RL +E A + G+ D + L D + P T+ LTY + +E+ D Sbjct: 2567 EPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFH 2626 Query: 4251 TGLCLLPLKE 4260 TGL LL + E Sbjct: 2627 TGLKLLEVSE 2636 Score = 206 bits (525), Expect = 3e-52 Identities = 161/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%) Query: 3111 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3170 F+GLR V A +L+E++++D +QL+ G ++V +V + T+ + L A IAG++LE Sbjct: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146 Query: 3171 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3230 +K+S +A ++ ++ +A+A LEAQA TG IIDP + +V++AV G+V PEF Sbjct: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206 Query: 3231 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3290 +LL AEKA GY Y+ +++S+FQA++ ++ R++G +L+AQ+++GG++DP + RVP Sbjct: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264 Query: 3291 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3350 ++A +G L+ + L P ++ + + +P+ + Y EL + C D + L P Sbjct: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324 Query: 3351 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3393 E+ + SEL E F++ +E + ++ + +E Sbjct: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384 Query: 3394 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3445 SS T + E + Q K V+K + LIT+ E ++L + L Sbjct: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444 Query: 3446 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3505 +PV L ASG E++ K + ++L + + L+ GI T +K Sbjct: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497 Query: 3506 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3565 + EA+ RGL+ A L + + + P+ N+ + V EAV A ++ E+ + L Sbjct: 2498 YRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLE 2557 Query: 3566 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3625 + G +P S +S+ +A+Q G++ + IAT Sbjct: 2558 FQYLTGGLIEPQVHSRLSIEEALQVGII---------DVLIAT----------------- 2591 Query: 3626 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3678 L D + P T LTY++ LE+ D TGL+LL Sbjct: 2592 ------------KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632 Score = 114 bits (284), Expect = 3e-24 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%) Query: 2797 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2854 E G + +++ +G T+ ELA R + S +AG L A+ E++SV A + Sbjct: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467 Query: 2855 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2914 R L+ TAL LEAQ ++G ++DP+ ++ V EA+ G+V +L E +TG Sbjct: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527 Query: 2915 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2974 P T + +S+ +A+ +I +E GIR LE Q TGG+I+P R+ ++ A + G D Sbjct: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587 Query: 2975 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 3034 + L D + P T LTY + LE+ D TGL LL +++ G +Y Sbjct: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647 Query: 3035 DS 3036 S Sbjct: 2648 SS 2649 Score = 64.3 bits (155), Expect = 3e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 527 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 586 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 Query: 587 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 >gi|221316624 dystonin isoform 4 [Homo sapiens] Length = 5526 Score = 861 bits (2224), Expect = 0.0 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%) Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 630 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 689 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 690 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 750 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 809 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 810 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 869 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 870 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 929 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 930 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 989 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 990 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1049 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 1050 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1109 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 1110 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1169 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1170 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1229 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1230 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1289 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1290 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1349 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1350 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1409 Query: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++ Sbjct: 1410 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1469 Query: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550 E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q Sbjct: 1470 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1522 Query: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1593 ++ ++++++ L++S +Q + ++ S +++EE+I V Sbjct: 1523 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1581 Query: 1594 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643 Q E E+ +G + G +A E +K Q+++ E L++ +Q Sbjct: 1582 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1639 Query: 1644 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1701 +Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V Sbjct: 1640 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1699 Query: 1702 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1757 A+ ET + +A +L+ + L ++ A + ++ E+ Q+ + Sbjct: 1700 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1759 Query: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1807 + A E E E+ L+ + ++ E + QQ +A+ EK + A+ Sbjct: 1760 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1818 Query: 1808 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1862 ++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ + Sbjct: 1819 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1878 Query: 1863 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916 E Q E+EL L+ A ++++ ++ + ++ + S R E ++ Sbjct: 1879 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1938 Query: 1917 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1962 S S++ +++ A R+L R R+L + + L + EDA+ Sbjct: 1939 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1998 Query: 1963 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 2012 A A + L+E +A + + + E AL+ ++ E+L++ AE Sbjct: 1999 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2058 Query: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 2069 R L + +++ + + S S ER + L + TL + V+ +E+L Sbjct: 2059 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2117 Query: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2124 + E + + ++ L ++ + ++ A RQ + A E+ ++ E Sbjct: 2118 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2174 Query: 2125 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178 + K L+A EA+ + K L ++E LK KVE L E+ + + Q E Sbjct: 2175 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2234 Query: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2237 E + Q QE + + L+ L + +++A V + Sbjct: 2235 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2288 Query: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297 ++ +++E+ + K+ A Q + A K K +E ++ Q + + Sbjct: 2289 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2348 Query: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2351 + +E KK E+ + ++++ ++ L T K + + L Sbjct: 2349 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2407 Query: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2404 E T + + L S++ M ++S E+ L+L+DK NT+ + Q Sbjct: 2408 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2462 Query: 2405 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463 EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK Sbjct: 2463 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2519 Query: 2464 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 + ELL++ + + ++ +L D++Q ++ + FQ T+EA Sbjct: 2520 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2578 Query: 2508 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549 + ++ L ++ + +++++ + E + + + E+ + Sbjct: 2579 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2638 Query: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2601 GE + ++ + Q + Q + + +AI + + + L+ Sbjct: 2639 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2698 Query: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661 + KL + Q L+ Q ++Q EK + + E L L ++E Sbjct: 2699 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2754 Query: 2662 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719 KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ + Sbjct: 2755 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2814 Query: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770 + A +L +LE + S+ +TA KT+ G + L Sbjct: 2815 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2857 Score = 563 bits (1452), Expect = e-159 Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF Sbjct: 60 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 119 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED Sbjct: 120 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 179 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 M+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL Sbjct: 180 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 239 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN++ Sbjct: 240 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 298 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 +++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K+ Sbjct: 299 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 358 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 + K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I Sbjct: 359 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 418 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ Sbjct: 419 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 478 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624 L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 479 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 508 Score = 111 bits (277), Expect = 2e-23 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%) Query: 1096 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1155 G S + Q++ + Q +S + +L D+ +L + + H + E A++ Sbjct: 2665 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2724 Query: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1215 Q I +Q+K Q +V A E + AL + L +LE L + V Sbjct: 2725 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2774 Query: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1267 + +++ L++ Q +A + KE Q + A L LE+ K Sbjct: 2775 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2834 Query: 1268 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 K L AQ+ + T + L + +G+++ +LQ + + Sbjct: 2835 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2878 Query: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384 W Q R+ +L++ + Y+E + L W+ + E+I+ D Sbjct: 2879 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2936 Query: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1417 + + ++L +E+++H VE A ++ K Sbjct: 2937 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2996 Query: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1476 + L+ +T K + S K ++Q E + I + + + + ++ T+ K + Sbjct: 2997 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3056 Query: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535 +++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q Sbjct: 3057 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3115 Query: 1536 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587 E+ + D + + + L++ E I+A ++ EA S Sbjct: 3116 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3174 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1636 + +++ L E T G + +L+AL +AR E+ E ++ +E +L Sbjct: 3175 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3233 Query: 1637 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1670 + + +ESQ E E ++ K E E + KQ+ Sbjct: 3234 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3293 Query: 1671 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1703 + Q LE + L + +RA Q+Q A Sbjct: 3294 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3353 Query: 1704 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760 L Q+ AE + +A E+ L+R L + V ++ E E+ A A++ Sbjct: 3354 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3412 Query: 1761 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1808 + + L RW+ N+A Q E VAQQ ++L EK+ E Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472 Query: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868 + K EEQ + + L + + + L + + + +++ R + + + + Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3529 Query: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928 + +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q Sbjct: 3530 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3586 Query: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1979 E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI Sbjct: 3587 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3641 Query: 1980 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 2033 + T+L T+ L++ RL E+ ++E + ++ + E A Sbjct: 3642 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3701 Query: 2034 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 2081 Q+R K E + K L+ D+L + E++ +A EK A E Sbjct: 3702 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3760 Query: 2082 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2134 E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E Sbjct: 3761 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3820 Query: 2135 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188 + K ++++ + K+ EE + ++++ ++ + Q +++ LQ E Sbjct: 3821 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3876 Query: 2189 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2243 +A + Q + +EL L + QS++ QL E E R+ EE + R Sbjct: 3877 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3936 Query: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2299 + + +L + + + + + AA+ L + +++ +RA A A+ Q Sbjct: 3937 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3996 Query: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2356 D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E Sbjct: 3997 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055 Query: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2415 + ++++ + VQ KL + EN ++ +++ + E AEK + Sbjct: 4056 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4109 Query: 2416 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2469 + + +R L + + +Q+ A + ++E++ +QE + +EL+ Sbjct: 4110 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4169 Query: 2470 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525 + K + ++ L + + + + + ++A Q Q + A + + + Sbjct: 4170 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4229 Query: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585 +++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L Sbjct: 4230 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4277 Query: 2586 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2633 + + E E +K +Q E KL+ EE +Q +L AL Q ++L Sbjct: 4278 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4336 Query: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2689 + + LL ++ + + +E E+AK L+ + Q +E + L+ S Sbjct: 4337 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4392 Query: 2690 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2745 EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R Sbjct: 4393 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4452 Query: 2746 LA 2747 LA Sbjct: 4453 LA 4454 Score = 94.0 bits (232), Expect = 3e-18 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%) Query: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1140 D + +R+ + S +LL + A+EE R + S+LK+ + L+ E Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3247 Query: 1141 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192 + + ++ E + + I Q Q +V LG+G+ + +A+ Sbjct: 3248 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3298 Query: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1252 S + L +L+ + + + A +L+ L Q A E L + +E Sbjct: 3299 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3357 Query: 1253 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1312 A + A K ++AQ + +Q L D+ + EV +R ++ + Sbjct: 3358 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3410 Query: 1313 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1370 + + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R Sbjct: 3411 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3470 Query: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430 + + S+ + EQ+ Q +AL ++I H + + + + + +V K Sbjct: 3471 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3529 Query: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1489 V + K S SE + Q + + + E ++ + + L ++ ++ E Sbjct: 3530 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3588 Query: 1490 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1533 +Q++E R R V+ AL +L + Q K +A + + + Sbjct: 3589 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3648 Query: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1587 + +V + E A+ ++ S EEL E E+ + K +A A+ + Sbjct: 3649 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3708 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647 ++E + + L++ + A EL RAR E ++ E+ ER R +Q+ Sbjct: 3709 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3763 Query: 1648 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1696 + + + AE E ++ L +L ++RL+ ++ +L+ E+ R Sbjct: 3764 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3823 Query: 1697 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1732 + V+ + +E E QS + +E+ QLER+ Sbjct: 3824 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3883 Query: 1733 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1774 L E ++QL E E QQQ E + RE E + +++ Sbjct: 3884 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3943 Query: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1833 + L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE Sbjct: 3944 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4003 Query: 1834 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1887 ++ E Q ++AE E I+ + + E+ + L E R + A + Sbjct: 4004 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4063 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1942 +++ A+ + + + V + E R EA+ ELAE+ + Sbjct: 4064 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4113 Query: 1943 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998 + + + R L + +Q+ EA + E++ + E E +I + Sbjct: 4114 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4164 Query: 1999 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057 +E + E D+ ++ ++E + L KA +++ +E+ ++ Sbjct: 4165 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4212 Query: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117 Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E Sbjct: 4213 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4268 Query: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177 R +AE ++K EE + L E++ + +EE R+ + + L Q Sbjct: 4269 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4326 Query: 2178 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228 A + L +QK E EL + + VL + EA +A Sbjct: 4327 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4385 Query: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288 + E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+ Sbjct: 4386 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4432 Query: 2289 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342 + Q + E+H ++ +T +++ V E+ EET K+L+ Sbjct: 4433 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4490 Query: 2343 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398 + Q L K+ T + + ++E+ SV ++ E K ++E E L + ++ Sbjct: 4491 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4546 Query: 2399 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2447 Q F+ +AE+ VA + L + + A E + + + E K Sbjct: 4547 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4606 Query: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 +K V L + ++ + E+ R L +D + A+Q E LE Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4665 Query: 2508 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564 + +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK Sbjct: 4666 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4717 Query: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2622 +L D +L + ++EL + + + KS E Q +E LL Sbjct: 4718 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4759 Query: 2623 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679 Q T ALQ +L + L ++ + + + L + A ++L + Q Sbjct: 4760 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4819 Query: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2723 R+ + S +++ + + +E R + + +LE RQ EE Sbjct: 4820 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4879 Query: 2724 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2760 LAE Q LR + L+ L +QH+ + EE A AT Sbjct: 4880 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4926 Score = 85.1 bits (209), Expect = 1e-15 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%) Query: 1263 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1317 EA++A + K+L+ +A+ + D+L EV L +E+ WR R Sbjct: 3697 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3741 Query: 1318 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 VA+ ER++ V + E++ + + + ++AD +W+ + ++ + + Sbjct: 3742 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3801 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V Sbjct: 3802 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3858 Query: 1435 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1480 + + QS + Y +L +E ++ SQ ETLR+ Sbjct: 3859 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3918 Query: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540 +EE R + AE + + ++ + +L+ + + A L +++E+V + Sbjct: 3919 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3978 Query: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1592 R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I Sbjct: 3979 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4037 Query: 1593 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1645 + +LQ L T +QRG E R+ + + + Q++ +++ + +E + Sbjct: 4038 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093 Query: 1646 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1695 K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++ Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4152 Query: 1696 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750 ++ + + E E + + S E + + SL + EEA + Sbjct: 4153 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4211 Query: 1751 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1803 A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+ Sbjct: 4212 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4271 Query: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863 +AE ++ + ++ Q L E +L L E ++ E L+ L Sbjct: 4272 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4323 Query: 1864 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1917 Q + L+E LA L ++++ + +E ELAK +LA ++ E +++ Sbjct: 4324 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4383 Query: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977 ++ +E+ AG EEA+ L+ E ++ Q E +++ + + L + Sbjct: 4384 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4433 Query: 1978 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 2026 GE L+ TE + + E E+L + AF+ + ++ K Sbjct: 4434 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4493 Query: 2027 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 2077 ++ LA+ K++++ +++ VE L +R+ EE L L F + Sbjct: 4494 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4551 Query: 2078 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133 +AE L + S DT+ L + ++ A E RE + K+ Sbjct: 4552 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4604 Query: 2134 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2178 + ++++ L + V+RL + R+RA+Q E+ +L E Sbjct: 4605 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4664 Query: 2179 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231 ++K L +E +K Q KE Q++L + SV D + + A+ Sbjct: 4665 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4722 Query: 2232 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283 + ++ + ++ R + VE +L+++ Q QA + L + Q A Sbjct: 4723 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781 Query: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343 +Q ++ HK F ++ ++ + V+ + R +E + + + Sbjct: 4782 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4836 Query: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2394 ++Q L + L + Q EE L+ EAE ++ Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2446 D+D + + + E MK++ E+ A L+ A + + D + RA E Sbjct: 4897 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4956 Query: 2447 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2501 ++L K+ Q + A L A+ ELL+ Q L + +++ Q EE + Sbjct: 4957 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5016 Query: 2502 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2554 Q +E ++Q ++ + K R A+ S Q+ + A R R A + Sbjct: 5017 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5076 Query: 2555 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606 +T++ T+ K V L ++R++ +L +A+ LE +E + + Sbjct: 5077 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5130 Query: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647 + K ++ +++ + + + ++D + R+ FI+ Sbjct: 5131 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5167 Score = 78.6 bits (192), Expect = 1e-13 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%) Query: 649 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 701 QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L + Sbjct: 3325 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3384 Query: 702 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 757 +++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S Sbjct: 3385 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3443 Query: 758 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 811 VA E + WL E+ V + + + + + + AL ++ K + + Sbjct: 3444 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3503 Query: 812 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 850 + G L + +R + Q+ L W +LQ C Sbjct: 3504 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3561 Query: 851 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 899 E H K + Q +S + + + +L+ LQE L RK + D+ A + LE Sbjct: 3562 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3620 Query: 900 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 947 L Q DE +++L K + +AK + +QL R H H Sbjct: 3621 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3680 Query: 948 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 1001 + E V KG+E + + K L S +E + ++ LVP +E Sbjct: 3681 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3739 Query: 1002 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1056 E + + + LV T+ ++ ++L Q + SW T + L Sbjct: 3740 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3799 Query: 1057 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1100 EQ Q L+ L ++ + D +G E++ +++ Sbjct: 3800 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3859 Query: 1101 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1149 +Y + Q + + R Q +++ + +L T T + +L P Sbjct: 3860 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3919 Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209 +E R+ + IAE + ++ G + LS + ++ E AA TL S+++ + Sbjct: 3920 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3977 Query: 1210 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265 K L++ S S + +K+ I E L E+L++ ++ A + +++ Sbjct: 3978 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4027 Query: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1323 + K + E QP ++ L+ GE + R G ++D+ + ++++ Q++ Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4080 Query: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383 W+ + + R+ +L + + L ++D + ++ P D V++ Sbjct: 4081 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4139 Query: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443 Q + + EEI+ E+++ + I A + + +V K ++ ++ Sbjct: 4140 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4188 Query: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503 S +S+ + + D E QY + L+ + + +A + A ++ + Sbjct: 4189 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4240 Query: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562 LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L Sbjct: 4241 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4297 Query: 1563 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1613 + S E I + + E A + + + + + L TE + GG ++ Sbjct: 4298 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4357 Query: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1672 A+ + Q E + + D + E AS ++ + E ++ Q L Sbjct: 4358 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4414 Query: 1673 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730 + E+ + Q + A R+ + E+E +Q L +R L SK +TA+ + Sbjct: 4415 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4468 Query: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1770 ++ E A + +EE + Q+ + AR E E +L Sbjct: 4469 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4528 Query: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830 + K EAL L ++ Q +AE+ A R + Q + A + Sbjct: 4529 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4588 Query: 1831 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886 + Q+ E GT + + +Q+++ ++ + + + + + L R A ++ Sbjct: 4589 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4648 Query: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946 ++ +K+ ME L S+ + E ++ K ++ + + +E + ++ Sbjct: 4649 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4703 Query: 1947 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 2000 + R R L E+ + A + + +L+E G++ + + E AL Sbjct: 4704 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4763 Query: 2001 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059 + L+ L + + + E+Q D+ L KA EL ++ V+ R R+ Sbjct: 4764 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4823 Query: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119 + ++ S + ++ K +++ EL R L +Q LEAA ++ AEE Sbjct: 4824 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4869 Query: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179 + + LA E+ R ++ + L+ +++ + ++ E++ A +L A Sbjct: 4870 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4928 Query: 2180 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232 L K ++ + +E+ +Q Q Q A A A +E E Sbjct: 4929 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4984 Query: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2287 A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R Sbjct: 4985 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5043 Query: 2288 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346 A+ ++L+ D K+F +L + Q+E + + NLL + Sbjct: 5044 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5095 Query: 2347 QRLKAEATEAARQRSQVEEELFSVR 2371 Q++ A E R+ + + L +R Sbjct: 5096 QQVWLLALERRRKLNDALDRLEELR 5120 Score = 69.3 bits (168), Expect = 8e-11 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%) Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1206 K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L Sbjct: 4247 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4299 Query: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1262 LE+ R ++ + KL+ L + Q A + L A E L E + V + Sbjct: 4300 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356 Query: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322 E A L+ A Q T +A+ + + ++ GE E + ++ L Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4407 Query: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1381 +RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL + Sbjct: 4408 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4465 Query: 1382 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1422 +EQL +E+ +++ + + C + A+ Q IN +K+ E + Sbjct: 4466 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4525 Query: 1423 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1482 L K +LE + A + + +Q++++ T + + S+ + L +++ Sbjct: 4526 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4579 Query: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542 E + A EV + E+ +L + K ++++ L + + V R Sbjct: 4580 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628 Query: 1543 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1598 E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4688 Query: 1599 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1654 + E Q+ GA+ + R + +K ++ + + +++D+ VE Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4748 Query: 1655 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712 ++++ + + ALQAL + R++ + AE + +++ + + L ++ + Sbjct: 4749 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4804 Query: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772 EL + +S L+RS +E + R+++ Q E RW+ Sbjct: 4805 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4847 Query: 1773 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828 L ++ RL + + S+ A E EAE+ R G + R L + Sbjct: 4848 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4906 Query: 1829 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887 Q E ++L E A+ A + + + + + AR + A A Q + Sbjct: 4907 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4966 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1940 Q L + LA + A+ E+L A A + + ++K K+ + E + L EE Sbjct: 4967 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5026 Query: 1941 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1990 R + ++ K ++ A + ++ Q RA +R A L G T+++T+ Sbjct: 5027 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5086 Query: 1991 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 2029 +AL+ + N+ L RL E F R++ K+ + Sbjct: 5087 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5146 Query: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 2088 + ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + + Sbjct: 5147 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5205 Query: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125 N + + ++E RQ+A + +R + E+ Sbjct: 5206 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5242 Score = 40.0 bits (92), Expect = 0.054 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%) Query: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360 + E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R Sbjct: 1067 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1125 Query: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420 + E +F + Q KLK +E L+++ + EE Sbjct: 1126 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1165 Query: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477 + A+ LR + +++ Q +++ + +K++ V + AE L + E Sbjct: 1166 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1224 Query: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537 + + DK + + L + ++ ++ +RQ + E ++ K EM + + Sbjct: 1225 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1283 Query: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597 D +++A+++ E+ + ++ ++ + + L + I ++E + Sbjct: 1284 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1343 Query: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657 K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ + Sbjct: 1344 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1394 Query: 2658 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714 + + + + + QQ+ ++++M+ ++ + R R L Sbjct: 1395 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1440 Query: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774 Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P Sbjct: 1441 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1500 Query: 2775 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2804 ++ + +++ ++ LQ + A+ Sbjct: 1501 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1530 Score = 35.0 bits (79), Expect = 1.8 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%) Query: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 560 + V+ W K+ ++ER + L +R + +KL E L +++ L S++ Sbjct: 4622 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4674 Query: 561 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 620 E+ D DK + + + Q +H + R L E+ Sbjct: 4675 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4720 Query: 621 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 672 + NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E Sbjct: 4721 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4778 Query: 673 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 732 Q D G D+ V + +H+ + + + + ++ + +L +R D Sbjct: 4779 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4833 Query: 733 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 778 + +Q +L L+ SK A LR E HS V A L WL E E+ + Sbjct: 4834 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4889 Query: 779 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 825 F D + + + M++LE K ++ + GD +L HP Sbjct: 4890 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4938 Score = 35.0 bits (79), Expect = 1.8 Identities = 22/51 (43%), Positives = 26/51 (50%) Query: 4594 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644 E +GL AA T+ S + S GS AGS+ GSR SR GS FD Sbjct: 5422 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5472 Score = 32.7 bits (73), Expect = 8.7 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%) Query: 642 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 694 +V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL Sbjct: 4630 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4689 Query: 695 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 749 H+ +S+ + + L T A D L L ++ + S R Sbjct: 4690 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4749 Query: 750 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 801 LE F T L WL E E++ D N+ +++ A +E Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4806 Query: 802 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 861 L + ++ L+ + L+ V+ L T+W + L + L+ Sbjct: 4807 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4866 Query: 862 FQFFSDVREA 871 + F V A Sbjct: 4867 AEEFHSVVHA 4876 >gi|221316622 dystonin isoform 3 [Homo sapiens] Length = 5537 Score = 861 bits (2224), Expect = 0.0 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%) Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 641 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 701 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 761 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 821 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 881 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 941 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420 Query: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++ Sbjct: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480 Query: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550 E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q Sbjct: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533 Query: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1593 ++ ++++++ L++S +Q + ++ S +++EE+I V Sbjct: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592 Query: 1594 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643 Q E E+ +G + G +A E +K Q+++ E L++ +Q Sbjct: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650 Query: 1644 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1701 +Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V Sbjct: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710 Query: 1702 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1757 A+ ET + +A +L+ + L ++ A + ++ E+ Q+ + Sbjct: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770 Query: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1807 + A E E E+ L+ + ++ E + QQ +A+ EK + A+ Sbjct: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829 Query: 1808 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1862 ++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ + Sbjct: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889 Query: 1863 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916 E Q E+EL L+ A ++++ ++ + ++ + S R E ++ Sbjct: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949 Query: 1917 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1962 S S++ +++ A R+L R R+L + + L + EDA+ Sbjct: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009 Query: 1963 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 2012 A A + L+E +A + + + E AL+ ++ E+L++ AE Sbjct: 2010 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2069 Query: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 2069 R L + +++ + + S S ER + L + TL + V+ +E+L Sbjct: 2070 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2128 Query: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2124 + E + + ++ L ++ + ++ A RQ + A E+ ++ E Sbjct: 2129 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2185 Query: 2125 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178 + K L+A EA+ + K L ++E LK KVE L E+ + + Q E Sbjct: 2186 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2245 Query: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2237 E + Q QE + + L+ L + +++A V + Sbjct: 2246 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2299 Query: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297 ++ +++E+ + K+ A Q + A K K +E ++ Q + + Sbjct: 2300 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2359 Query: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2351 + +E KK E+ + ++++ ++ L T K + + L Sbjct: 2360 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2418 Query: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2404 E T + + L S++ M ++S E+ L+L+DK NT+ + Q Sbjct: 2419 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2473 Query: 2405 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463 EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK Sbjct: 2474 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2530 Query: 2464 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 + ELL++ + + ++ +L D++Q ++ + FQ T+EA Sbjct: 2531 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2589 Query: 2508 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549 + ++ L ++ + +++++ + E + + + E+ + Sbjct: 2590 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2649 Query: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2601 GE + ++ + Q + Q + + +AI + + + L+ Sbjct: 2650 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2709 Query: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661 + KL + Q L+ Q ++Q EK + + E L L ++E Sbjct: 2710 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2765 Query: 2662 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719 KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ + Sbjct: 2766 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2825 Query: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770 + A +L +LE + S+ +TA KT+ G + L Sbjct: 2826 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868 Score = 563 bits (1452), Expect = e-159 Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF Sbjct: 71 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 130 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED Sbjct: 131 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 190 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 M+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL Sbjct: 191 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 250 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN++ Sbjct: 251 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 309 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 +++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K+ Sbjct: 310 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 369 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 + K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I Sbjct: 370 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 429 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ Sbjct: 430 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 489 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624 L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 490 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 519 Score = 111 bits (277), Expect = 2e-23 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%) Query: 1096 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1155 G S + Q++ + Q +S + +L D+ +L + + H + E A++ Sbjct: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735 Query: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1215 Q I +Q+K Q +V A E + AL + L +LE L + V Sbjct: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785 Query: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1267 + +++ L++ Q +A + KE Q + A L LE+ K Sbjct: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845 Query: 1268 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 K L AQ+ + T + L + +G+++ +LQ + + Sbjct: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889 Query: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384 W Q R+ +L++ + Y+E + L W+ + E+I+ D Sbjct: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2947 Query: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1417 + + ++L +E+++H VE A ++ K Sbjct: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007 Query: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1476 + L+ +T K + S K ++Q E + I + + + + ++ T+ K + Sbjct: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067 Query: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535 +++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q Sbjct: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3126 Query: 1536 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587 E+ + D + + + L++ E I+A ++ EA S Sbjct: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1636 + +++ L E T G + +L+AL +AR E+ E ++ +E +L Sbjct: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244 Query: 1637 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1670 + + +ESQ E E ++ K E E + KQ+ Sbjct: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304 Query: 1671 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1703 + Q LE + L + +RA Q+Q A Sbjct: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364 Query: 1704 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760 L Q+ AE + +A E+ L+R L + V ++ E E+ A A++ Sbjct: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423 Query: 1761 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1808 + + L RW+ N+A Q E VAQQ ++L EK+ E Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483 Query: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868 + K EEQ + + L + + + L + + + +++ R + + + + Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540 Query: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928 + +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3597 Query: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1979 E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI Sbjct: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652 Query: 1980 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 2033 + T+L T+ L++ RL E+ ++E + ++ + E A Sbjct: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712 Query: 2034 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 2081 Q+R K E + K L+ D+L + E++ +A EK A E Sbjct: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771 Query: 2082 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2134 E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E Sbjct: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831 Query: 2135 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188 + K ++++ + K+ EE + ++++ ++ + Q +++ LQ E Sbjct: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3887 Query: 2189 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2243 +A + Q + +EL L + QS++ QL E E R+ EE + R Sbjct: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947 Query: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2299 + + +L + + + + + AA+ L + +++ +RA A A+ Q Sbjct: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 4007 Query: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2356 D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E Sbjct: 4008 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066 Query: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2415 + ++++ + VQ KL + EN ++ +++ + E AEK + Sbjct: 4067 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4120 Query: 2416 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2469 + + +R L + + +Q+ A + ++E++ +QE + +EL+ Sbjct: 4121 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4180 Query: 2470 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525 + K + ++ L + + + + + ++A Q Q + A + + + Sbjct: 4181 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4240 Query: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585 +++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L Sbjct: 4241 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4288 Query: 2586 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2633 + + E E +K +Q E KL+ EE +Q +L AL Q ++L Sbjct: 4289 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4347 Query: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2689 + + LL ++ + + +E E+AK L+ + Q +E + L+ S Sbjct: 4348 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4403 Query: 2690 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2745 EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R Sbjct: 4404 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4463 Query: 2746 LA 2747 LA Sbjct: 4464 LA 4465 Score = 94.0 bits (232), Expect = 3e-18 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%) Query: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1140 D + +R+ + S +LL + A+EE R + S+LK+ + L+ E Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258 Query: 1141 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192 + + ++ E + + I Q Q +V LG+G+ + +A+ Sbjct: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309 Query: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1252 S + L +L+ + + + A +L+ L Q A E L + +E Sbjct: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368 Query: 1253 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1312 A + A K ++AQ + +Q L D+ + EV +R ++ + Sbjct: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421 Query: 1313 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1370 + + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R Sbjct: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481 Query: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430 + + S+ + EQ+ Q +AL ++I H + + + + + +V K Sbjct: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540 Query: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1489 V + K S SE + Q + + + E ++ + + L ++ ++ E Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599 Query: 1490 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1533 +Q++E R R V+ AL +L + Q K +A + + + Sbjct: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659 Query: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1587 + +V + E A+ ++ S EEL E E+ + K +A A+ + Sbjct: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647 ++E + + L++ + A EL RAR E ++ E+ ER R +Q+ Sbjct: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774 Query: 1648 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1696 + + + AE E ++ L +L ++RL+ ++ +L+ E+ R Sbjct: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834 Query: 1697 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1732 + V+ + +E E QS + +E+ QLER+ Sbjct: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894 Query: 1733 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1774 L E ++QL E E QQQ E + RE E + +++ Sbjct: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954 Query: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1833 + L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE Sbjct: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014 Query: 1834 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1887 ++ E Q ++AE E I+ + + E+ + L E R + A + Sbjct: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1942 +++ A+ + + + V + E R EA+ ELAE+ + Sbjct: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124 Query: 1943 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998 + + + R L + +Q+ EA + E++ + E E +I + Sbjct: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175 Query: 1999 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057 +E + E D+ ++ ++E + L KA +++ +E+ ++ Sbjct: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223 Query: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117 Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E Sbjct: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279 Query: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177 R +AE ++K EE + L E++ + +EE R+ + + L Q Sbjct: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337 Query: 2178 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228 A + L +QK E EL + + VL + EA +A Sbjct: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396 Query: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288 + E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+ Sbjct: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443 Query: 2289 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342 + Q + E+H ++ +T +++ V E+ EET K+L+ Sbjct: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501 Query: 2343 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398 + Q L K+ T + + ++E+ SV ++ E K ++E E L + ++ Sbjct: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557 Query: 2399 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2447 Q F+ +AE+ VA + L + + A E + + + E K Sbjct: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617 Query: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 +K V L + ++ + E+ R L +D + A+Q E LE Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676 Query: 2508 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564 + +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK Sbjct: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728 Query: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2622 +L D +L + ++EL + + + KS E Q +E LL Sbjct: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770 Query: 2623 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679 Q T ALQ +L + L ++ + + + L + A ++L + Q Sbjct: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830 Query: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2723 R+ + S +++ + + +E R + + +LE RQ EE Sbjct: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890 Query: 2724 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2760 LAE Q LR + L+ L +QH+ + EE A AT Sbjct: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937 Score = 85.1 bits (209), Expect = 1e-15 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%) Query: 1263 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1317 EA++A + K+L+ +A+ + D+L EV L +E+ WR R Sbjct: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752 Query: 1318 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 VA+ ER++ V + E++ + + + ++AD +W+ + ++ + + Sbjct: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V Sbjct: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869 Query: 1435 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1480 + + QS + Y +L +E ++ SQ ETLR+ Sbjct: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929 Query: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540 +EE R + AE + + ++ + +L+ + + A L +++E+V + Sbjct: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989 Query: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1592 R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I Sbjct: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048 Query: 1593 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1645 + +LQ L T +QRG E R+ + + + Q++ +++ + +E + Sbjct: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104 Query: 1646 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1695 K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++ Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163 Query: 1696 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750 ++ + + E E + + S E + + SL + EEA + Sbjct: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222 Query: 1751 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1803 A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+ Sbjct: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282 Query: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863 +AE ++ + ++ Q L E +L L E ++ E L+ L Sbjct: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334 Query: 1864 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1917 Q + L+E LA L ++++ + +E ELAK +LA ++ E +++ Sbjct: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394 Query: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977 ++ +E+ AG EEA+ L+ E ++ Q E +++ + + L + Sbjct: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444 Query: 1978 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 2026 GE L+ TE + + E E+L + AF+ + ++ K Sbjct: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504 Query: 2027 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 2077 ++ LA+ K++++ +++ VE L +R+ EE L L F + Sbjct: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562 Query: 2078 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133 +AE L + S DT+ L + ++ A E RE + K+ Sbjct: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615 Query: 2134 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2178 + ++++ L + V+RL + R+RA+Q E+ +L E Sbjct: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675 Query: 2179 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231 ++K L +E +K Q KE Q++L + SV D + + A+ Sbjct: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733 Query: 2232 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283 + ++ + ++ R + VE +L+++ Q QA + L + Q A Sbjct: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792 Query: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343 +Q ++ HK F ++ ++ + V+ + R +E + + + Sbjct: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847 Query: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2394 ++Q L + L + Q EE L+ EAE ++ Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2446 D+D + + + E MK++ E+ A L+ A + + D + RA E Sbjct: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967 Query: 2447 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2501 ++L K+ Q + A L A+ ELL+ Q L + +++ Q EE + Sbjct: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027 Query: 2502 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2554 Q +E ++Q ++ + K R A+ S Q+ + A R R A + Sbjct: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087 Query: 2555 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606 +T++ T+ K V L ++R++ +L +A+ LE +E + + Sbjct: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141 Query: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647 + K ++ +++ + + + ++D + R+ FI+ Sbjct: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178 Score = 78.6 bits (192), Expect = 1e-13 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%) Query: 649 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 701 QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L + Sbjct: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395 Query: 702 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 757 +++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S Sbjct: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454 Query: 758 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 811 VA E + WL E+ V + + + + + + AL ++ K + + Sbjct: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514 Query: 812 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 850 + G L + +R + Q+ L W +LQ C Sbjct: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572 Query: 851 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 899 E H K + Q +S + + + +L+ LQE L RK + D+ A + LE Sbjct: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631 Query: 900 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 947 L Q DE +++L K + +AK + +QL R H H Sbjct: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691 Query: 948 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 1001 + E V KG+E + + K L S +E + ++ LVP +E Sbjct: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750 Query: 1002 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1056 E + + + LV T+ ++ ++L Q + SW T + L Sbjct: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810 Query: 1057 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1100 EQ Q L+ L ++ + D +G E++ +++ Sbjct: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870 Query: 1101 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1149 +Y + Q + + R Q +++ + +L T T + +L P Sbjct: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930 Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209 +E R+ + IAE + ++ G + LS + ++ E AA TL S+++ + Sbjct: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988 Query: 1210 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265 K L++ S S + +K+ I E L E+L++ ++ A + +++ Sbjct: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038 Query: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1323 + K + E QP ++ L+ GE + R G ++D+ + ++++ Q++ Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091 Query: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383 W+ + + R+ +L + + L ++D + ++ P D V++ Sbjct: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150 Query: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443 Q + + EEI+ E+++ + I A + + +V K ++ ++ Sbjct: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199 Query: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503 S +S+ + + D E QY + L+ + + +A + A ++ + Sbjct: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251 Query: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562 LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L Sbjct: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308 Query: 1563 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1613 + S E I + + E A + + + + + L TE + GG ++ Sbjct: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368 Query: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1672 A+ + Q E + + D + E AS ++ + E ++ Q L Sbjct: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425 Query: 1673 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730 + E+ + Q + A R+ + E+E +Q L +R L SK +TA+ + Sbjct: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479 Query: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1770 ++ E A + +EE + Q+ + AR E E +L Sbjct: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539 Query: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830 + K EAL L ++ Q +AE+ A R + Q + A + Sbjct: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599 Query: 1831 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886 + Q+ E GT + + +Q+++ ++ + + + + + L R A ++ Sbjct: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659 Query: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946 ++ +K+ ME L S+ + E ++ K ++ + + +E + ++ Sbjct: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714 Query: 1947 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 2000 + R R L E+ + A + + +L+E G++ + + E AL Sbjct: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774 Query: 2001 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059 + L+ L + + + E+Q D+ L KA EL ++ V+ R R+ Sbjct: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834 Query: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119 + ++ S + ++ K +++ EL R L +Q LEAA ++ AEE Sbjct: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880 Query: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179 + + LA E+ R ++ + L+ +++ + ++ E++ A +L A Sbjct: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939 Query: 2180 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232 L K ++ + +E+ +Q Q Q A A A +E E Sbjct: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995 Query: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2287 A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R Sbjct: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054 Query: 2288 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346 A+ ++L+ D K+F +L + Q+E + + NLL + Sbjct: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106 Query: 2347 QRLKAEATEAARQRSQVEEELFSVR 2371 Q++ A E R+ + + L +R Sbjct: 5107 QQVWLLALERRRKLNDALDRLEELR 5131 Score = 69.3 bits (168), Expect = 8e-11 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%) Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1206 K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L Sbjct: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310 Query: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1262 LE+ R ++ + KL+ L + Q A + L A E L E + V + Sbjct: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367 Query: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322 E A L+ A Q T +A+ + + ++ GE E + ++ L Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418 Query: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1381 +RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL + Sbjct: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476 Query: 1382 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1422 +EQL +E+ +++ + + C + A+ Q IN +K+ E + Sbjct: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536 Query: 1423 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1482 L K +LE + A + + +Q++++ T + + S+ + L +++ Sbjct: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590 Query: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542 E + A EV + E+ +L + K ++++ L + + V R Sbjct: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639 Query: 1543 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1598 E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699 Query: 1599 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1654 + E Q+ GA+ + R + +K ++ + + +++D+ VE Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759 Query: 1655 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712 ++++ + + ALQAL + R++ + AE + +++ + + L ++ + Sbjct: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815 Query: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772 EL + +S L+RS +E + R+++ Q E RW+ Sbjct: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858 Query: 1773 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828 L ++ RL + + S+ A E EAE+ R G + R L + Sbjct: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917 Query: 1829 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887 Q E ++L E A+ A + + + + + AR + A A Q + Sbjct: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1940 Q L + LA + A+ E+L A A + + ++K K+ + E + L EE Sbjct: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037 Query: 1941 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1990 R + ++ K ++ A + ++ Q RA +R A L G T+++T+ Sbjct: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097 Query: 1991 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 2029 +AL+ + N+ L RL E F R++ K+ + Sbjct: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157 Query: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 2088 + ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + + Sbjct: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216 Query: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125 N + + ++E RQ+A + +R + E+ Sbjct: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253 Score = 40.0 bits (92), Expect = 0.054 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%) Query: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360 + E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R Sbjct: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136 Query: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420 + E +F + Q KLK +E L+++ + EE Sbjct: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176 Query: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477 + A+ LR + +++ Q +++ + +K++ V + AE L + E Sbjct: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235 Query: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537 + + DK + + L + ++ ++ +RQ + E ++ K EM + + Sbjct: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294 Query: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597 D +++A+++ E+ + ++ ++ + + L + I ++E + Sbjct: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354 Query: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657 K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ + Sbjct: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405 Query: 2658 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714 + + + + + QQ+ ++++M+ ++ + R R L Sbjct: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451 Query: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774 Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P Sbjct: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511 Query: 2775 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2804 ++ + +++ ++ LQ + A+ Sbjct: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541 Score = 35.0 bits (79), Expect = 1.8 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%) Query: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 560 + V+ W K+ ++ER + L +R + +KL E L +++ L S++ Sbjct: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685 Query: 561 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 620 E+ D DK + + + Q +H + R L E+ Sbjct: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731 Query: 621 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 672 + NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E Sbjct: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789 Query: 673 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 732 Q D G D+ V + +H+ + + + + ++ + +L +R D Sbjct: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844 Query: 733 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 778 + +Q +L L+ SK A LR E HS V A L WL E E+ + Sbjct: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4900 Query: 779 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 825 F D + + + M++LE K ++ + GD +L HP Sbjct: 4901 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949 Score = 35.0 bits (79), Expect = 1.8 Identities = 22/51 (43%), Positives = 26/51 (50%) Query: 4594 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644 E +GL AA T+ S + S GS AGS+ GSR SR GS FD Sbjct: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483 Score = 32.7 bits (73), Expect = 8.7 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%) Query: 642 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 694 +V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL Sbjct: 4641 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4700 Query: 695 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 749 H+ +S+ + + L T A D L L ++ + S R Sbjct: 4701 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4760 Query: 750 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 801 LE F T L WL E E++ D N+ +++ A +E Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4817 Query: 802 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 861 L + ++ L+ + L+ V+ L T+W + L + L+ Sbjct: 4818 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877 Query: 862 FQFFSDVREA 871 + F V A Sbjct: 4878 AEEFHSVVHA 4887 >gi|221316618 dystonin isoform 2 [Homo sapiens] Length = 5675 Score = 861 bits (2224), Expect = 0.0 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%) Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 779 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 838 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 839 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 899 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 958 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 959 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 1018 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 1019 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 1078 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 1079 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1138 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 1139 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1198 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 1199 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1258 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 1259 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1318 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1319 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1378 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1379 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1438 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1439 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1498 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1499 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1558 Query: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++ Sbjct: 1559 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1618 Query: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550 E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q Sbjct: 1619 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1671 Query: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1593 ++ ++++++ L++S +Q + ++ S +++EE+I V Sbjct: 1672 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1730 Query: 1594 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643 Q E E+ +G + G +A E +K Q+++ E L++ +Q Sbjct: 1731 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1788 Query: 1644 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1701 +Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V Sbjct: 1789 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1848 Query: 1702 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1757 A+ ET + +A +L+ + L ++ A + ++ E+ Q+ + Sbjct: 1849 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1908 Query: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1807 + A E E E+ L+ + ++ E + QQ +A+ EK + A+ Sbjct: 1909 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1967 Query: 1808 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1862 ++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ + Sbjct: 1968 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 2027 Query: 1863 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916 E Q E+EL L+ A ++++ ++ + ++ + S R E ++ Sbjct: 2028 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 2087 Query: 1917 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1962 S S++ +++ A R+L R R+L + + L + EDA+ Sbjct: 2088 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2147 Query: 1963 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 2012 A A + L+E +A + + + E AL+ ++ E+L++ AE Sbjct: 2148 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2207 Query: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 2069 R L + +++ + + S S ER + L + TL + V+ +E+L Sbjct: 2208 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2266 Query: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2124 + E + + ++ L ++ + ++ A RQ + A E+ ++ E Sbjct: 2267 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2323 Query: 2125 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178 + K L+A EA+ + K L ++E LK KVE L E+ + + Q E Sbjct: 2324 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2383 Query: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2237 E + Q QE + + L+ L + +++A V + Sbjct: 2384 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2437 Query: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297 ++ +++E+ + K+ A Q + A K K +E ++ Q + + Sbjct: 2438 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2497 Query: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2351 + +E KK E+ + ++++ ++ L T K + + L Sbjct: 2498 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2556 Query: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2404 E T + + L S++ M ++S E+ L+L+DK NT+ + Q Sbjct: 2557 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2611 Query: 2405 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463 EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK Sbjct: 2612 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2668 Query: 2464 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 + ELL++ + + ++ +L D++Q ++ + FQ T+EA Sbjct: 2669 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2727 Query: 2508 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549 + ++ L ++ + +++++ + E + + + E+ + Sbjct: 2728 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2787 Query: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2601 GE + ++ + Q + Q + + +AI + + + L+ Sbjct: 2788 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2847 Query: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661 + KL + Q L+ Q ++Q EK + + E L L ++E Sbjct: 2848 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2903 Query: 2662 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719 KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ + Sbjct: 2904 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2963 Query: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770 + A +L +LE + S+ +TA KT+ G + L Sbjct: 2964 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 3006 Score = 563 bits (1452), Expect = e-159 Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF Sbjct: 209 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 268 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED Sbjct: 269 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 328 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 M+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL Sbjct: 329 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 388 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN++ Sbjct: 389 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 447 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 +++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K+ Sbjct: 448 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 507 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 + K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I Sbjct: 508 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 567 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ Sbjct: 568 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 627 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624 L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 628 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 657 Score = 111 bits (277), Expect = 2e-23 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%) Query: 1096 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1155 G S + Q++ + Q +S + +L D+ +L + + H + E A++ Sbjct: 2814 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2873 Query: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1215 Q I +Q+K Q +V A E + AL + L +LE L + V Sbjct: 2874 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2923 Query: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1267 + +++ L++ Q +A + KE Q + A L LE+ K Sbjct: 2924 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2983 Query: 1268 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 K L AQ+ + T + L + +G+++ +LQ + + Sbjct: 2984 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 3027 Query: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384 W Q R+ +L++ + Y+E + L W+ + E+I+ D Sbjct: 3028 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 3085 Query: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1417 + + ++L +E+++H VE A ++ K Sbjct: 3086 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3145 Query: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1476 + L+ +T K + S K ++Q E + I + + + + ++ T+ K + Sbjct: 3146 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3205 Query: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535 +++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q Sbjct: 3206 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3264 Query: 1536 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587 E+ + D + + + L++ E I+A ++ EA S Sbjct: 3265 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3323 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1636 + +++ L E T G + +L+AL +AR E+ E ++ +E +L Sbjct: 3324 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3382 Query: 1637 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1670 + + +ESQ E E ++ K E E + KQ+ Sbjct: 3383 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3442 Query: 1671 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1703 + Q LE + L + +RA Q+Q A Sbjct: 3443 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3502 Query: 1704 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760 L Q+ AE + +A E+ L+R L + V ++ E E+ A A++ Sbjct: 3503 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3561 Query: 1761 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1808 + + L RW+ N+A Q E VAQQ ++L EK+ E Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621 Query: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868 + K EEQ + + L + + + L + + + +++ R + + + + Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3678 Query: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928 + +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q Sbjct: 3679 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3735 Query: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1979 E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI Sbjct: 3736 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3790 Query: 1980 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 2033 + T+L T+ L++ RL E+ ++E + ++ + E A Sbjct: 3791 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3850 Query: 2034 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 2081 Q+R K E + K L+ D+L + E++ +A EK A E Sbjct: 3851 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3909 Query: 2082 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2134 E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E Sbjct: 3910 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3969 Query: 2135 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188 + K ++++ + K+ EE + ++++ ++ + Q +++ LQ E Sbjct: 3970 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 4025 Query: 2189 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2243 +A + Q + +EL L + QS++ QL E E R+ EE + R Sbjct: 4026 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 4085 Query: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2299 + + +L + + + + + AA+ L + +++ +RA A A+ Q Sbjct: 4086 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 4145 Query: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2356 D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E Sbjct: 4146 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204 Query: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2415 + ++++ + VQ KL + EN ++ +++ + E AEK + Sbjct: 4205 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4258 Query: 2416 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2469 + + +R L + + +Q+ A + ++E++ +QE + +EL+ Sbjct: 4259 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4318 Query: 2470 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525 + K + ++ L + + + + + ++A Q Q + A + + + Sbjct: 4319 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4378 Query: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585 +++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L Sbjct: 4379 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4426 Query: 2586 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2633 + + E E +K +Q E KL+ EE +Q +L AL Q ++L Sbjct: 4427 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4485 Query: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2689 + + LL ++ + + +E E+AK L+ + Q +E + L+ S Sbjct: 4486 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4541 Query: 2690 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2745 EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R Sbjct: 4542 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4601 Query: 2746 LA 2747 LA Sbjct: 4602 LA 4603 Score = 94.0 bits (232), Expect = 3e-18 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%) Query: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1140 D + +R+ + S +LL + A+EE R + S+LK+ + L+ E Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3396 Query: 1141 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192 + + ++ E + + I Q Q +V LG+G+ + +A+ Sbjct: 3397 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3447 Query: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1252 S + L +L+ + + + A +L+ L Q A E L + +E Sbjct: 3448 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3506 Query: 1253 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1312 A + A K ++AQ + +Q L D+ + EV +R ++ + Sbjct: 3507 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559 Query: 1313 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1370 + + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R Sbjct: 3560 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3619 Query: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430 + + S+ + EQ+ Q +AL ++I H + + + + + +V K Sbjct: 3620 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3678 Query: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1489 V + K S SE + Q + + + E ++ + + L ++ ++ E Sbjct: 3679 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3737 Query: 1490 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1533 +Q++E R R V+ AL +L + Q K +A + + + Sbjct: 3738 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3797 Query: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1587 + +V + E A+ ++ S EEL E E+ + K +A A+ + Sbjct: 3798 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3857 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647 ++E + + L++ + A EL RAR E ++ E+ ER R +Q+ Sbjct: 3858 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3912 Query: 1648 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1696 + + + AE E ++ L +L ++RL+ ++ +L+ E+ R Sbjct: 3913 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3972 Query: 1697 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1732 + V+ + +E E QS + +E+ QLER+ Sbjct: 3973 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 4032 Query: 1733 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1774 L E ++QL E E QQQ E + RE E + +++ Sbjct: 4033 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 4092 Query: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1833 + L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE Sbjct: 4093 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4152 Query: 1834 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1887 ++ E Q ++AE E I+ + + E+ + L E R + A + Sbjct: 4153 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4212 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1942 +++ A+ + + + V + E R EA+ ELAE+ + Sbjct: 4213 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4262 Query: 1943 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998 + + + R L + +Q+ EA + E++ + E E +I + Sbjct: 4263 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4313 Query: 1999 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057 +E + E D+ ++ ++E + L KA +++ +E+ ++ Sbjct: 4314 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4361 Query: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117 Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E Sbjct: 4362 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4417 Query: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177 R +AE ++K EE + L E++ + +EE R+ + + L Q Sbjct: 4418 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4475 Query: 2178 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228 A + L +QK E EL + + VL + EA +A Sbjct: 4476 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4534 Query: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288 + E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+ Sbjct: 4535 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4581 Query: 2289 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342 + Q + E+H ++ +T +++ V E+ EET K+L+ Sbjct: 4582 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4639 Query: 2343 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398 + Q L K+ T + + ++E+ SV ++ E K ++E E L + ++ Sbjct: 4640 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4695 Query: 2399 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2447 Q F+ +AE+ VA + L + + A E + + + E K Sbjct: 4696 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4755 Query: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 +K V L + ++ + E+ R L +D + A+Q E LE Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4814 Query: 2508 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564 + +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK Sbjct: 4815 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4866 Query: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2622 +L D +L + ++EL + + + KS E Q +E LL Sbjct: 4867 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4908 Query: 2623 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679 Q T ALQ +L + L ++ + + + L + A ++L + Q Sbjct: 4909 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4968 Query: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2723 R+ + S +++ + + +E R + + +LE RQ EE Sbjct: 4969 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 5028 Query: 2724 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2760 LAE Q LR + L+ L +QH+ + EE A AT Sbjct: 5029 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 5075 Score = 85.1 bits (209), Expect = 1e-15 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%) Query: 1263 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1317 EA++A + K+L+ +A+ + D+L EV L +E+ WR R Sbjct: 3846 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3890 Query: 1318 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 VA+ ER++ V + E++ + + + ++AD +W+ + ++ + + Sbjct: 3891 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3950 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V Sbjct: 3951 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 4007 Query: 1435 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1480 + + QS + Y +L +E ++ SQ ETLR+ Sbjct: 4008 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 4067 Query: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540 +EE R + AE + + ++ + +L+ + + A L +++E+V + Sbjct: 4068 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 4127 Query: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1592 R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I Sbjct: 4128 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4186 Query: 1593 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1645 + +LQ L T +QRG E R+ + + + Q++ +++ + +E + Sbjct: 4187 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242 Query: 1646 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1695 K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++ Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4301 Query: 1696 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750 ++ + + E E + + S E + + SL + EEA + Sbjct: 4302 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4360 Query: 1751 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1803 A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+ Sbjct: 4361 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4420 Query: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863 +AE ++ + ++ Q L E +L L E ++ E L+ L Sbjct: 4421 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4472 Query: 1864 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1917 Q + L+E LA L ++++ + +E ELAK +LA ++ E +++ Sbjct: 4473 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4532 Query: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977 ++ +E+ AG EEA+ L+ E ++ Q E +++ + + L + Sbjct: 4533 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4582 Query: 1978 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 2026 GE L+ TE + + E E+L + AF+ + ++ K Sbjct: 4583 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4642 Query: 2027 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 2077 ++ LA+ K++++ +++ VE L +R+ EE L L F + Sbjct: 4643 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4700 Query: 2078 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133 +AE L + S DT+ L + ++ A E RE + K+ Sbjct: 4701 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4753 Query: 2134 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2178 + ++++ L + V+RL + R+RA+Q E+ +L E Sbjct: 4754 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4813 Query: 2179 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231 ++K L +E +K Q KE Q++L + SV D + + A+ Sbjct: 4814 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4871 Query: 2232 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283 + ++ + ++ R + VE +L+++ Q QA + L + Q A Sbjct: 4872 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930 Query: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343 +Q ++ HK F ++ ++ + V+ + R +E + + + Sbjct: 4931 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4985 Query: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2394 ++Q L + L + Q EE L+ EAE ++ Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2446 D+D + + + E MK++ E+ A L+ A + + D + RA E Sbjct: 5046 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 5105 Query: 2447 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2501 ++L K+ Q + A L A+ ELL+ Q L + +++ Q EE + Sbjct: 5106 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5165 Query: 2502 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2554 Q +E ++Q ++ + K R A+ S Q+ + A R R A + Sbjct: 5166 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5225 Query: 2555 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606 +T++ T+ K V L ++R++ +L +A+ LE +E + + Sbjct: 5226 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5279 Query: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647 + K ++ +++ + + + ++D + R+ FI+ Sbjct: 5280 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5316 Score = 78.6 bits (192), Expect = 1e-13 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%) Query: 649 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 701 QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L + Sbjct: 3474 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3533 Query: 702 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 757 +++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S Sbjct: 3534 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3592 Query: 758 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 811 VA E + WL E+ V + + + + + + AL ++ K + + Sbjct: 3593 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3652 Query: 812 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 850 + G L + +R + Q+ L W +LQ C Sbjct: 3653 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3710 Query: 851 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 899 E H K + Q +S + + + +L+ LQE L RK + D+ A + LE Sbjct: 3711 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3769 Query: 900 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 947 L Q DE +++L K + +AK + +QL R H H Sbjct: 3770 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3829 Query: 948 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 1001 + E V KG+E + + K L S +E + ++ LVP +E Sbjct: 3830 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3888 Query: 1002 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1056 E + + + LV T+ ++ ++L Q + SW T + L Sbjct: 3889 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3948 Query: 1057 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1100 EQ Q L+ L ++ + D +G E++ +++ Sbjct: 3949 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 4008 Query: 1101 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1149 +Y + Q + + R Q +++ + +L T T + +L P Sbjct: 4009 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 4068 Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209 +E R+ + IAE + ++ G + LS + ++ E AA TL S+++ + Sbjct: 4069 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 4126 Query: 1210 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265 K L++ S S + +K+ I E L E+L++ ++ A + +++ Sbjct: 4127 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4176 Query: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1323 + K + E QP ++ L+ GE + R G ++D+ + ++++ Q++ Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4229 Query: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383 W+ + + R+ +L + + L ++D + ++ P D V++ Sbjct: 4230 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4288 Query: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443 Q + + EEI+ E+++ + I A + + +V K ++ ++ Sbjct: 4289 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4337 Query: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503 S +S+ + + D E QY + L+ + + +A + A ++ + Sbjct: 4338 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4389 Query: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562 LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L Sbjct: 4390 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4446 Query: 1563 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1613 + S E I + + E A + + + + + L TE + GG ++ Sbjct: 4447 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4506 Query: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1672 A+ + Q E + + D + E AS ++ + E ++ Q L Sbjct: 4507 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4563 Query: 1673 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730 + E+ + Q + A R+ + E+E +Q L +R L SK +TA+ + Sbjct: 4564 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4617 Query: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1770 ++ E A + +EE + Q+ + AR E E +L Sbjct: 4618 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4677 Query: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830 + K EAL L ++ Q +AE+ A R + Q + A + Sbjct: 4678 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4737 Query: 1831 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886 + Q+ E GT + + +Q+++ ++ + + + + + L R A ++ Sbjct: 4738 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4797 Query: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946 ++ +K+ ME L S+ + E ++ K ++ + + +E + ++ Sbjct: 4798 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4852 Query: 1947 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 2000 + R R L E+ + A + + +L+E G++ + + E AL Sbjct: 4853 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4912 Query: 2001 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059 + L+ L + + + E+Q D+ L KA EL ++ V+ R R+ Sbjct: 4913 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4972 Query: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119 + ++ S + ++ K +++ EL R L +Q LEAA ++ AEE Sbjct: 4973 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 5018 Query: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179 + + LA E+ R ++ + L+ +++ + ++ E++ A +L A Sbjct: 5019 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 5077 Query: 2180 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232 L K ++ + +E+ +Q Q Q A A A +E E Sbjct: 5078 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 5133 Query: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2287 A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R Sbjct: 5134 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5192 Query: 2288 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346 A+ ++L+ D K+F +L + Q+E + + NLL + Sbjct: 5193 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5244 Query: 2347 QRLKAEATEAARQRSQVEEELFSVR 2371 Q++ A E R+ + + L +R Sbjct: 5245 QQVWLLALERRRKLNDALDRLEELR 5269 Score = 69.3 bits (168), Expect = 8e-11 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%) Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1206 K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L Sbjct: 4396 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4448 Query: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1262 LE+ R ++ + KL+ L + Q A + L A E L E + V + Sbjct: 4449 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505 Query: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322 E A L+ A Q T +A+ + + ++ GE E + ++ L Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4556 Query: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1381 +RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL + Sbjct: 4557 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4614 Query: 1382 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1422 +EQL +E+ +++ + + C + A+ Q IN +K+ E + Sbjct: 4615 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4674 Query: 1423 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1482 L K +LE + A + + +Q++++ T + + S+ + L +++ Sbjct: 4675 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4728 Query: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542 E + A EV + E+ +L + K ++++ L + + V R Sbjct: 4729 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777 Query: 1543 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1598 E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4837 Query: 1599 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1654 + E Q+ GA+ + R + +K ++ + + +++D+ VE Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4897 Query: 1655 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712 ++++ + + ALQAL + R++ + AE + +++ + + L ++ + Sbjct: 4898 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4953 Query: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772 EL + +S L+RS +E + R+++ Q E RW+ Sbjct: 4954 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4996 Query: 1773 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828 L ++ RL + + S+ A E EAE+ R G + R L + Sbjct: 4997 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 5055 Query: 1829 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887 Q E ++L E A+ A + + + + + AR + A A Q + Sbjct: 5056 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 5115 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1940 Q L + LA + A+ E+L A A + + ++K K+ + E + L EE Sbjct: 5116 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5175 Query: 1941 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1990 R + ++ K ++ A + ++ Q RA +R A L G T+++T+ Sbjct: 5176 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5235 Query: 1991 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 2029 +AL+ + N+ L RL E F R++ K+ + Sbjct: 5236 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5295 Query: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 2088 + ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + + Sbjct: 5296 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5354 Query: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125 N + + ++E RQ+A + +R + E+ Sbjct: 5355 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5391 Score = 40.0 bits (92), Expect = 0.054 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%) Query: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360 + E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R Sbjct: 1216 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1274 Query: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420 + E +F + Q KLK +E L+++ + EE Sbjct: 1275 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1314 Query: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477 + A+ LR + +++ Q +++ + +K++ V + AE L + E Sbjct: 1315 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1373 Query: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537 + + DK + + L + ++ ++ +RQ + E ++ K EM + + Sbjct: 1374 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1432 Query: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597 D +++A+++ E+ + ++ ++ + + L + I ++E + Sbjct: 1433 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1492 Query: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657 K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ + Sbjct: 1493 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1543 Query: 2658 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714 + + + + + QQ+ ++++M+ ++ + R R L Sbjct: 1544 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1589 Query: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774 Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P Sbjct: 1590 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1649 Query: 2775 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2804 ++ + +++ ++ LQ + A+ Sbjct: 1650 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1679 Score = 35.0 bits (79), Expect = 1.8 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%) Query: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 560 + V+ W K+ ++ER + L +R + +KL E L +++ L S++ Sbjct: 4771 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4823 Query: 561 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 620 E+ D DK + + + Q +H + R L E+ Sbjct: 4824 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4869 Query: 621 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 672 + NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E Sbjct: 4870 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4927 Query: 673 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 732 Q D G D+ V + +H+ + + + + ++ + +L +R D Sbjct: 4928 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4982 Query: 733 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 778 + +Q +L L+ SK A LR E HS V A L WL E E+ + Sbjct: 4983 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 5038 Query: 779 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 825 F D + + + M++LE K ++ + GD +L HP Sbjct: 5039 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 5087 Score = 35.0 bits (79), Expect = 1.8 Identities = 22/51 (43%), Positives = 26/51 (50%) Query: 4594 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644 E +GL AA T+ S + S GS AGS+ GSR SR GS FD Sbjct: 5571 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5621 Score = 32.7 bits (73), Expect = 8.7 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%) Query: 642 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 694 +V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL Sbjct: 4779 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4838 Query: 695 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 749 H+ +S+ + + L T A D L L ++ + S R Sbjct: 4839 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4898 Query: 750 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 801 LE F T L WL E E++ D N+ +++ A +E Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4955 Query: 802 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 861 L + ++ L+ + L+ V+ L T+W + L + L+ Sbjct: 4956 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 5015 Query: 862 FQFFSDVREA 871 + F V A Sbjct: 5016 AEEFHSVVHA 5025 >gi|34577047 dystonin isoform 1 [Homo sapiens] Length = 5497 Score = 861 bits (2224), Expect = 0.0 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%) Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 601 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 661 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 721 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 781 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 841 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 901 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 961 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380 Query: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++ Sbjct: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440 Query: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550 E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q Sbjct: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493 Query: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1593 ++ ++++++ L++S +Q + ++ S +++EE+I V Sbjct: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552 Query: 1594 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643 Q E E+ +G + G +A E +K Q+++ E L++ +Q Sbjct: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610 Query: 1644 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1701 +Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V Sbjct: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670 Query: 1702 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1757 A+ ET + +A +L+ + L ++ A + ++ E+ Q+ + Sbjct: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730 Query: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1807 + A E E E+ L+ + ++ E + QQ +A+ EK + A+ Sbjct: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789 Query: 1808 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1862 ++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ + Sbjct: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849 Query: 1863 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916 E Q E+EL L+ A ++++ ++ + ++ + S R E ++ Sbjct: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909 Query: 1917 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1962 S S++ +++ A R+L R R+L + + L + EDA+ Sbjct: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969 Query: 1963 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 2012 A A + L+E +A + + + E AL+ ++ E+L++ AE Sbjct: 1970 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2029 Query: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 2069 R L + +++ + + S S ER + L + TL + V+ +E+L Sbjct: 2030 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2088 Query: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2124 + E + + ++ L ++ + ++ A RQ + A E+ ++ E Sbjct: 2089 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2145 Query: 2125 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178 + K L+A EA+ + K L ++E LK KVE L E+ + + Q E Sbjct: 2146 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2205 Query: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2237 E + Q QE + + L+ L + +++A V + Sbjct: 2206 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2259 Query: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297 ++ +++E+ + K+ A Q + A K K +E ++ Q + + Sbjct: 2260 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2319 Query: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2351 + +E KK E+ + ++++ ++ L T K + + L Sbjct: 2320 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2378 Query: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2404 E T + + L S++ M ++S E+ L+L+DK NT+ + Q Sbjct: 2379 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2433 Query: 2405 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463 EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK Sbjct: 2434 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2490 Query: 2464 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 + ELL++ + + ++ +L D++Q ++ + FQ T+EA Sbjct: 2491 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2549 Query: 2508 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549 + ++ L ++ + +++++ + E + + + E+ + Sbjct: 2550 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2609 Query: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2601 GE + ++ + Q + Q + + +AI + + + L+ Sbjct: 2610 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2669 Query: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661 + KL + Q L+ Q ++Q EK + + E L L ++E Sbjct: 2670 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2725 Query: 2662 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719 KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ + Sbjct: 2726 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2785 Query: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770 + A +L +LE + S+ +TA KT+ G + L Sbjct: 2786 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828 Score = 563 bits (1452), Expect = e-159 Identities = 270/450 (60%), Positives = 361/450 (80%), Gaps = 1/450 (0%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234 DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD+LPREKGRMRF Sbjct: 31 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRF 90 Query: 235 HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294 H+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQISDI V+G+SED Sbjct: 91 HRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED 150 Query: 295 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354 M+AKE+LLLW+Q+ EGY G+RC+NFT+ WRDG+LFNAIIH+++P LIDMN V Q+NL Sbjct: 151 MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLIDMNTVAVQSNLA 210 Query: 355 NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414 NL+ AF VAE+ +GV RLLDPEDVDV PDEKS+ITYVSSLYDA P+VP+ +G+ AN++ Sbjct: 211 NLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVPEGGEGIGANDV 269 Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 +++W EY+ +V L+QW+RHH ER FP++ E++ L++Q+L+FKE E+P KE +K+ Sbjct: 270 EVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKETEIPPKETEKS 329 Query: 475 RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534 + K +Y+ LE ++ G++K+ GYHP D+EKEWGKL +A+LEREK LR E ERLE LQ+I Sbjct: 330 KIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRPEVERLEMLQQI 389 Query: 535 VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594 ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++R DVQ Sbjct: 390 ANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLLRQHVIDVQ 449 Query: 595 TLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624 L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 450 ILIDGKYYQADQLVQRVAKLRDEIMALRNE 479 Score = 111 bits (277), Expect = 2e-23 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%) Query: 1096 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1155 G S + Q++ + Q +S + +L D+ +L + + H + E A++ Sbjct: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695 Query: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1215 Q I +Q+K Q +V A E + AL + L +LE L + V Sbjct: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745 Query: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1267 + +++ L++ Q +A + KE Q + A L LE+ K Sbjct: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805 Query: 1268 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 K L AQ+ + T + L + +G+++ +LQ + + Sbjct: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849 Query: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384 W Q R+ +L++ + Y+E + L W+ + E+I+ D Sbjct: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2907 Query: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1417 + + ++L +E+++H VE A ++ K Sbjct: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967 Query: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1476 + L+ +T K + S K ++Q E + I + + + + ++ T+ K + Sbjct: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027 Query: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535 +++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q Sbjct: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3086 Query: 1536 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587 E+ + D + + + L++ E I+A ++ EA S Sbjct: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1636 + +++ L E T G + +L+AL +AR E+ E ++ +E +L Sbjct: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204 Query: 1637 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1670 + + +ESQ E E ++ K E E + KQ+ Sbjct: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264 Query: 1671 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1703 + Q LE + L + +RA Q+Q A Sbjct: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324 Query: 1704 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760 L Q+ AE + +A E+ L+R L + V ++ E E+ A A++ Sbjct: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383 Query: 1761 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1808 + + L RW+ N+A Q E VAQQ ++L EK+ E Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443 Query: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868 + K EEQ + + L + + + L + + + +++ R + + + + Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500 Query: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928 + +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q Sbjct: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3557 Query: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1979 E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI Sbjct: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612 Query: 1980 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 2033 + T+L T+ L++ RL E+ ++E + ++ + E A Sbjct: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672 Query: 2034 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 2081 Q+R K E + K L+ D+L + E++ +A EK A E Sbjct: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731 Query: 2082 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2134 E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E Sbjct: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791 Query: 2135 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188 + K ++++ + K+ EE + ++++ ++ + Q +++ LQ E Sbjct: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3847 Query: 2189 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2243 +A + Q + +EL L + QS++ QL E E R+ EE + R Sbjct: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907 Query: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2299 + + +L + + + + + AA+ L + +++ +RA A A+ Q Sbjct: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3967 Query: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2356 D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E Sbjct: 3968 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026 Query: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2415 + ++++ + VQ KL + EN ++ +++ + E AEK + Sbjct: 4027 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4080 Query: 2416 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2469 + + +R L + + +Q+ A + ++E++ +QE + +EL+ Sbjct: 4081 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4140 Query: 2470 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525 + K + ++ L + + + + + ++A Q Q + A + + + Sbjct: 4141 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4200 Query: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585 +++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L Sbjct: 4201 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4248 Query: 2586 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2633 + + E E +K +Q E KL+ EE +Q +L AL Q ++L Sbjct: 4249 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4307 Query: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2689 + + LL ++ + + +E E+AK L+ + Q +E + L+ S Sbjct: 4308 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4363 Query: 2690 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2745 EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R Sbjct: 4364 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4423 Query: 2746 LA 2747 LA Sbjct: 4424 LA 4425 Score = 94.0 bits (232), Expect = 3e-18 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%) Query: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1140 D + +R+ + S +LL + A+EE R + S+LK+ + L+ E Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218 Query: 1141 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192 + + ++ E + + I Q Q +V LG+G+ + +A+ Sbjct: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269 Query: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1252 S + L +L+ + + + A +L+ L Q A E L + +E Sbjct: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328 Query: 1253 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1312 A + A K ++AQ + +Q L D+ + EV +R ++ + Sbjct: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381 Query: 1313 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1370 + + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R Sbjct: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441 Query: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430 + + S+ + EQ+ Q +AL ++I H + + + + + +V K Sbjct: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500 Query: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1489 V + K S SE + Q + + + E ++ + + L ++ ++ E Sbjct: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559 Query: 1490 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1533 +Q++E R R V+ AL +L + Q K +A + + + Sbjct: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619 Query: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1587 + +V + E A+ ++ S EEL E E+ + K +A A+ + Sbjct: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647 ++E + + L++ + A EL RAR E ++ E+ ER R +Q+ Sbjct: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734 Query: 1648 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1696 + + + AE E ++ L +L ++RL+ ++ +L+ E+ R Sbjct: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794 Query: 1697 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1732 + V+ + +E E QS + +E+ QLER+ Sbjct: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854 Query: 1733 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1774 L E ++QL E E QQQ E + RE E + +++ Sbjct: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914 Query: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1833 + L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE Sbjct: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974 Query: 1834 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1887 ++ E Q ++AE E I+ + + E+ + L E R + A + Sbjct: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1942 +++ A+ + + + V + E R EA+ ELAE+ + Sbjct: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084 Query: 1943 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998 + + + R L + +Q+ EA + E++ + E E +I + Sbjct: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135 Query: 1999 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057 +E + E D+ ++ ++E + L KA +++ +E+ ++ Sbjct: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183 Query: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117 Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E Sbjct: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239 Query: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177 R +AE ++K EE + L E++ + +EE R+ + + L Q Sbjct: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297 Query: 2178 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228 A + L +QK E EL + + VL + EA +A Sbjct: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356 Query: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288 + E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+ Sbjct: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403 Query: 2289 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342 + Q + E+H ++ +T +++ V E+ EET K+L+ Sbjct: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461 Query: 2343 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398 + Q L K+ T + + ++E+ SV ++ E K ++E E L + ++ Sbjct: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517 Query: 2399 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2447 Q F+ +AE+ VA + L + + A E + + + E K Sbjct: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577 Query: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 +K V L + ++ + E+ R L +D + A+Q E LE Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636 Query: 2508 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564 + +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK Sbjct: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688 Query: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2622 +L D +L + ++EL + + + KS E Q +E LL Sbjct: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730 Query: 2623 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679 Q T ALQ +L + L ++ + + + L + A ++L + Q Sbjct: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790 Query: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2723 R+ + S +++ + + +E R + + +LE RQ EE Sbjct: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850 Query: 2724 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2760 LAE Q LR + L+ L +QH+ + EE A AT Sbjct: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897 Score = 85.1 bits (209), Expect = 1e-15 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%) Query: 1263 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1317 EA++A + K+L+ +A+ + D+L EV L +E+ WR R Sbjct: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712 Query: 1318 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 VA+ ER++ V + E++ + + + ++AD +W+ + ++ + + Sbjct: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V Sbjct: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829 Query: 1435 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1480 + + QS + Y +L +E ++ SQ ETLR+ Sbjct: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889 Query: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540 +EE R + AE + + ++ + +L+ + + A L +++E+V + Sbjct: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949 Query: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1592 R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I Sbjct: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008 Query: 1593 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1645 + +LQ L T +QRG E R+ + + + Q++ +++ + +E + Sbjct: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064 Query: 1646 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1695 K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++ Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123 Query: 1696 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750 ++ + + E E + + S E + + SL + EEA + Sbjct: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182 Query: 1751 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1803 A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+ Sbjct: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242 Query: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863 +AE ++ + ++ Q L E +L L E ++ E L+ L Sbjct: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294 Query: 1864 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1917 Q + L+E LA L ++++ + +E ELAK +LA ++ E +++ Sbjct: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354 Query: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977 ++ +E+ AG EEA+ L+ E ++ Q E +++ + + L + Sbjct: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404 Query: 1978 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 2026 GE L+ TE + + E E+L + AF+ + ++ K Sbjct: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464 Query: 2027 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 2077 ++ LA+ K++++ +++ VE L +R+ EE L L F + Sbjct: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522 Query: 2078 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133 +AE L + S DT+ L + ++ A E RE + K+ Sbjct: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575 Query: 2134 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2178 + ++++ L + V+RL + R+RA+Q E+ +L E Sbjct: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635 Query: 2179 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231 ++K L +E +K Q KE Q++L + SV D + + A+ Sbjct: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693 Query: 2232 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283 + ++ + ++ R + VE +L+++ Q QA + L + Q A Sbjct: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752 Query: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343 +Q ++ HK F ++ ++ + V+ + R +E + + + Sbjct: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807 Query: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2394 ++Q L + L + Q EE L+ EAE ++ Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2446 D+D + + + E MK++ E+ A L+ A + + D + RA E Sbjct: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927 Query: 2447 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2501 ++L K+ Q + A L A+ ELL+ Q L + +++ Q EE + Sbjct: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987 Query: 2502 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2554 Q +E ++Q ++ + K R A+ S Q+ + A R R A + Sbjct: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047 Query: 2555 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606 +T++ T+ K V L ++R++ +L +A+ LE +E + + Sbjct: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101 Query: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647 + K ++ +++ + + + ++D + R+ FI+ Sbjct: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138 Score = 78.6 bits (192), Expect = 1e-13 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%) Query: 649 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 701 QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L + Sbjct: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355 Query: 702 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 757 +++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S Sbjct: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414 Query: 758 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 811 VA E + WL E+ V + + + + + + AL ++ K + + Sbjct: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474 Query: 812 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 850 + G L + +R + Q+ L W +LQ C Sbjct: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532 Query: 851 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 899 E H K + Q +S + + + +L+ LQE L RK + D+ A + LE Sbjct: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591 Query: 900 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 947 L Q DE +++L K + +AK + +QL R H H Sbjct: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651 Query: 948 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 1001 + E V KG+E + + K L S +E + ++ LVP +E Sbjct: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710 Query: 1002 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1056 E + + + LV T+ ++ ++L Q + SW T + L Sbjct: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770 Query: 1057 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1100 EQ Q L+ L ++ + D +G E++ +++ Sbjct: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830 Query: 1101 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1149 +Y + Q + + R Q +++ + +L T T + +L P Sbjct: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890 Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209 +E R+ + IAE + ++ G + LS + ++ E AA TL S+++ + Sbjct: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948 Query: 1210 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265 K L++ S S + +K+ I E L E+L++ ++ A + +++ Sbjct: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998 Query: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1323 + K + E QP ++ L+ GE + R G ++D+ + ++++ Q++ Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051 Query: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383 W+ + + R+ +L + + L ++D + ++ P D V++ Sbjct: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110 Query: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443 Q + + EEI+ E+++ + I A + + +V K ++ ++ Sbjct: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159 Query: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503 S +S+ + + D E QY + L+ + + +A + A ++ + Sbjct: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211 Query: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562 LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L Sbjct: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268 Query: 1563 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1613 + S E I + + E A + + + + + L TE + GG ++ Sbjct: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328 Query: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1672 A+ + Q E + + D + E AS ++ + E ++ Q L Sbjct: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385 Query: 1673 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730 + E+ + Q + A R+ + E+E +Q L +R L SK +TA+ + Sbjct: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439 Query: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1770 ++ E A + +EE + Q+ + AR E E +L Sbjct: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499 Query: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830 + K EAL L ++ Q +AE+ A R + Q + A + Sbjct: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559 Query: 1831 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886 + Q+ E GT + + +Q+++ ++ + + + + + L R A ++ Sbjct: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619 Query: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946 ++ +K+ ME L S+ + E ++ K ++ + + +E + ++ Sbjct: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674 Query: 1947 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 2000 + R R L E+ + A + + +L+E G++ + + E AL Sbjct: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734 Query: 2001 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059 + L+ L + + + E+Q D+ L KA EL ++ V+ R R+ Sbjct: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794 Query: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119 + ++ S + ++ K +++ EL R L +Q LEAA ++ AEE Sbjct: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840 Query: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179 + + LA E+ R ++ + L+ +++ + ++ E++ A +L A Sbjct: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899 Query: 2180 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232 L K ++ + +E+ +Q Q Q A A A +E E Sbjct: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955 Query: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2287 A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R Sbjct: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014 Query: 2288 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346 A+ ++L+ D K+F +L + Q+E + + NLL + Sbjct: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066 Query: 2347 QRLKAEATEAARQRSQVEEELFSVR 2371 Q++ A E R+ + + L +R Sbjct: 5067 QQVWLLALERRRKLNDALDRLEELR 5091 Score = 69.3 bits (168), Expect = 8e-11 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%) Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1206 K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L Sbjct: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270 Query: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1262 LE+ R ++ + KL+ L + Q A + L A E L E + V + Sbjct: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327 Query: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322 E A L+ A Q T +A+ + + ++ GE E + ++ L Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378 Query: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1381 +RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL + Sbjct: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436 Query: 1382 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1422 +EQL +E+ +++ + + C + A+ Q IN +K+ E + Sbjct: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496 Query: 1423 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1482 L K +LE + A + + +Q++++ T + + S+ + L +++ Sbjct: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550 Query: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542 E + A EV + E+ +L + K ++++ L + + V R Sbjct: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599 Query: 1543 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1598 E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL Sbjct: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659 Query: 1599 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1654 + E Q+ GA+ + R + +K ++ + + +++D+ VE Sbjct: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719 Query: 1655 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712 ++++ + + ALQAL + R++ + AE + +++ + + L ++ + Sbjct: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775 Query: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772 EL + +S L+RS +E + R+++ Q E RW+ Sbjct: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818 Query: 1773 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828 L ++ RL + + S+ A E EAE+ R G + R L + Sbjct: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877 Query: 1829 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887 Q E ++L E A+ A + + + + + AR + A A Q + Sbjct: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1940 Q L + LA + A+ E+L A A + + ++K K+ + E + L EE Sbjct: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997 Query: 1941 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1990 R + ++ K ++ A + ++ Q RA +R A L G T+++T+ Sbjct: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057 Query: 1991 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 2029 +AL+ + N+ L RL E F R++ K+ + Sbjct: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117 Query: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 2088 + ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + + Sbjct: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176 Query: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125 N + + ++E RQ+A + +R + E+ Sbjct: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213 Score = 40.0 bits (92), Expect = 0.054 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%) Query: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360 + E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R Sbjct: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096 Query: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420 + E +F + Q KLK +E L+++ + EE Sbjct: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136 Query: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477 + A+ LR + +++ Q +++ + +K++ V + AE L + E Sbjct: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195 Query: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537 + + DK + + L + ++ ++ +RQ + E ++ K EM + + Sbjct: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254 Query: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597 D +++A+++ E+ + ++ ++ + + L + I ++E + Sbjct: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314 Query: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657 K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ + Sbjct: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365 Query: 2658 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714 + + + + + QQ+ ++++M+ ++ + R R L Sbjct: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411 Query: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774 Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P Sbjct: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471 Query: 2775 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2804 ++ + +++ ++ LQ + A+ Sbjct: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501 Score = 35.0 bits (79), Expect = 1.8 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%) Query: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 560 + V+ W K+ ++ER + L +R + +KL E L +++ L S++ Sbjct: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645 Query: 561 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 620 E+ D DK + + + Q +H + R L E+ Sbjct: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691 Query: 621 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 672 + NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E Sbjct: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749 Query: 673 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 732 Q D G D+ V + +H+ + + + + ++ + +L +R D Sbjct: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804 Query: 733 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 778 + +Q +L L+ SK A LR E HS V A L WL E E+ + Sbjct: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4860 Query: 779 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 825 F D + + + M++LE K ++ + GD +L HP Sbjct: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909 Score = 35.0 bits (79), Expect = 1.8 Identities = 22/51 (43%), Positives = 26/51 (50%) Query: 4594 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644 E +GL AA T+ S + S GS AGS+ GSR SR GS FD Sbjct: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443 Score = 32.7 bits (73), Expect = 8.7 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%) Query: 642 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 694 +V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL Sbjct: 4601 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4660 Query: 695 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 749 H+ +S+ + + L T A D L L ++ + S R Sbjct: 4661 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4720 Query: 750 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 801 LE F T L WL E E++ D N+ +++ A +E Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4777 Query: 802 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 861 L + ++ L+ + L+ V+ L T+W + L + L+ Sbjct: 4778 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837 Query: 862 FQFFSDVREA 871 + F V A Sbjct: 4838 AEEFHSVVHA 4847 >gi|34577049 dystonin isoform 1eA precursor [Homo sapiens] Length = 5171 Score = 861 bits (2224), Expect = 0.0 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%) Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 Query: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++ Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114 Query: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550 E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q Sbjct: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167 Query: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1593 ++ ++++++ L++S +Q + ++ S +++EE+I V Sbjct: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1226 Query: 1594 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1643 Q E E+ +G + G +A E +K Q+++ E L++ +Q Sbjct: 1227 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1284 Query: 1644 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1701 +Q + + +K E ++ +AL Q L E +++ E+ + Q++ E + V Sbjct: 1285 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1344 Query: 1702 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1757 A+ ET + +A +L+ + L ++ A + ++ E+ Q+ + Sbjct: 1345 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1404 Query: 1758 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1807 + A E E E+ L+ + ++ E + QQ +A+ EK + A+ Sbjct: 1405 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1463 Query: 1808 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1862 ++G+ EE+ Q+ + E ++ + LAE + +L + ++EL + A+ + Sbjct: 1464 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1523 Query: 1863 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916 E Q E+EL L+ A ++++ ++ + ++ + S R E ++ Sbjct: 1524 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1583 Query: 1917 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1962 S S++ +++ A R+L R R+L + + L + EDA+ Sbjct: 1584 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1643 Query: 1963 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 2012 A A + L+E +A + + + E AL+ ++ E+L++ AE Sbjct: 1644 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 1703 Query: 2013 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 2069 R L + +++ + + S S ER + L + TL + V+ +E+L Sbjct: 1704 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 1762 Query: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 2124 + E + + ++ L ++ + ++ A RQ + A E+ ++ E Sbjct: 1763 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 1819 Query: 2125 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2178 + K L+A EA+ + K L ++E LK KVE L E+ + + Q E Sbjct: 1820 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 1879 Query: 2179 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2237 E + Q QE + + L+ L + +++A V + Sbjct: 1880 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 1933 Query: 2238 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2297 ++ +++E+ + K+ A Q + A K K +E ++ Q + + Sbjct: 1934 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 1993 Query: 2298 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2351 + +E KK E+ + ++++ ++ L T K + + L Sbjct: 1994 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2052 Query: 2352 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2404 E T + + L S++ M ++S E+ L+L+DK NT+ + Q Sbjct: 2053 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2107 Query: 2405 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2463 EE+ M Q ++ + + Q+ A A + +Q E LK+ + VQE LK Sbjct: 2108 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2164 Query: 2464 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 + ELL++ + + ++ +L D++Q ++ + FQ T+EA Sbjct: 2165 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2223 Query: 2508 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2549 + ++ L ++ + +++++ + E + + + E+ + Sbjct: 2224 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2283 Query: 2550 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2601 GE + ++ + Q + Q + + +AI + + + L+ Sbjct: 2284 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2343 Query: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2661 + KL + Q L+ Q ++Q EK + + E L L ++E Sbjct: 2344 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2399 Query: 2662 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2719 KA+ R+ + + + +EQ+ + V ++ A H+ ++ R Q L ++++ + Sbjct: 2400 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2459 Query: 2720 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2770 + A +L +LE + S+ +TA KT+ G + L Sbjct: 2460 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2502 Score = 111 bits (277), Expect = 2e-23 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%) Query: 1096 GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 1155 G S + Q++ + Q +S + +L D+ +L + + H + E A++ Sbjct: 2310 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2369 Query: 1156 CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1215 Q I +Q+K Q +V A E + AL + L +LE L + V Sbjct: 2370 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2419 Query: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1267 + +++ L++ Q +A + KE Q + A L LE+ K Sbjct: 2420 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2479 Query: 1268 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 K L AQ+ + T + L + +G+++ +LQ + + Sbjct: 2480 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2523 Query: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384 W Q R+ +L++ + Y+E + L W+ + E+I+ D Sbjct: 2524 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2581 Query: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1417 + + ++L +E+++H VE A ++ K Sbjct: 2582 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2641 Query: 1418 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1476 + L+ +T K + S K ++Q E + I + + + + ++ T+ K + Sbjct: 2642 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 2701 Query: 1477 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1535 +++ +RLA+ E + + L+ + +A+ H+ Q + + L+ ++Q Sbjct: 2702 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 2760 Query: 1536 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1587 E+ + D + + + L++ E I+A ++ EA S Sbjct: 2761 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 2819 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1636 + +++ L E T G + +L+AL +AR E+ E ++ +E +L Sbjct: 2820 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 2878 Query: 1637 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1670 + + +ESQ E E ++ K E E + KQ+ Sbjct: 2879 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 2938 Query: 1671 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1703 + Q LE + L + +RA Q+Q A Sbjct: 2939 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 2998 Query: 1704 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1760 L Q+ AE + +A E+ L+R L + V ++ E E+ A A++ Sbjct: 2999 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3057 Query: 1761 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1808 + + L RW+ N+A Q E VAQQ ++L EK+ E Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117 Query: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868 + K EEQ + + L + + + L + + + +++ R + + + + Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3174 Query: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1928 + +Q ++ + ++ Q+ AK+ E EV L + E S+ S Q Sbjct: 3175 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3231 Query: 1929 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1979 E L ++ + LR L E+ ++Q ++ + +Q E ++ +KL AI Sbjct: 3232 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3286 Query: 1980 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 2033 + T+L T+ L++ RL E+ ++E + ++ + E A Sbjct: 3287 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3346 Query: 2034 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 2081 Q+R K E + K L+ D+L + E++ +A EK A E Sbjct: 3347 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3405 Query: 2082 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 2134 E++ +RS D E + + ++ ++ + E+ + A+ +VQK+ E Sbjct: 3406 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3465 Query: 2135 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2188 + K ++++ + K+ EE + ++++ ++ + Q +++ LQ E Sbjct: 3466 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3521 Query: 2189 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2243 +A + Q + +EL L + QS++ QL E E R+ EE + R Sbjct: 3522 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3581 Query: 2244 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2299 + + +L + + + + + AA+ L + +++ +RA A A+ Q Sbjct: 3582 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3641 Query: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2356 D +E ++ E+ LRQ + E+ ++ Q+ E + L + LK E Sbjct: 3642 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700 Query: 2357 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2415 + ++++ + VQ KL + EN ++ +++ + E AEK + Sbjct: 3701 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 3754 Query: 2416 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2469 + + +R L + + +Q+ A + ++E++ +QE + +EL+ Sbjct: 3755 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 3814 Query: 2470 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2525 + K + ++ L + + + + + ++A Q Q + A + + + Sbjct: 3815 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 3874 Query: 2526 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2585 +++ + + D + ++Q EE+ K ++E Q +I+ ++ +H AE L Sbjct: 3875 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 3922 Query: 2586 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2633 + + E E +K +Q E KL+ EE +Q +L AL Q ++L Sbjct: 3923 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 3981 Query: 2634 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2689 + + LL ++ + + +E E+AK L+ + Q +E + L+ S Sbjct: 3982 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4037 Query: 2690 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2745 EEA Q++ E +R Q L++ EQ+++Q + L + + + + Q L + R Sbjct: 4038 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4097 Query: 2746 LA 2747 LA Sbjct: 4098 LA 4099 Score = 94.0 bits (232), Expect = 3e-18 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%) Query: 1087 DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 1140 D + +R+ + S +LL + A+EE R + S+LK+ + L+ E Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 2892 Query: 1141 VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1192 + + ++ E + + I Q Q +V LG+G+ + +A+ Sbjct: 2893 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 2943 Query: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1252 S + L +L+ + + + A +L+ L Q A E L + +E Sbjct: 2944 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3002 Query: 1253 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1312 A + A K ++AQ + +Q L D+ + EV +R ++ + Sbjct: 3003 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3055 Query: 1313 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1370 + + ++++ L RW+A+L + + R R+LE + + + E+ +PL WL +R Sbjct: 3056 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3115 Query: 1371 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1430 + + S+ + EQ+ Q +AL ++I H + + + + + +V K Sbjct: 3116 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3174 Query: 1431 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1489 V + K S SE + Q + + + E ++ + + L ++ ++ E Sbjct: 3175 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3233 Query: 1490 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1533 +Q++E R R V+ AL +L + Q K +A + + + Sbjct: 3234 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3293 Query: 1534 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1587 + +V + E A+ ++ S EEL E E+ + K +A A+ + Sbjct: 3294 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3353 Query: 1588 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1647 ++E + + L++ + A EL RAR E ++ E+ ER R +Q+ Sbjct: 3354 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3408 Query: 1648 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1696 + + + AE E ++ L +L ++RL+ ++ +L+ E+ R Sbjct: 3409 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3468 Query: 1697 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1732 + V+ + +E E QS + +E+ QLER+ Sbjct: 3469 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3528 Query: 1733 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1774 L E ++QL E E QQQ E + RE E + +++ Sbjct: 3529 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3588 Query: 1775 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1833 + L L Q+K +A Q KE+ ++ A +A Q+ + + +Q LE Sbjct: 3589 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3648 Query: 1834 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1887 ++ E Q ++AE E I+ + + E+ + L E R + A + Sbjct: 3649 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 3708 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1942 +++ A+ + + + V + E R EA+ ELAE+ + Sbjct: 3709 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 3758 Query: 1943 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998 + + + R L + +Q+ EA + E++ + E E +I + Sbjct: 3759 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 3809 Query: 1999 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 2057 +E + E D+ ++ ++E + L KA +++ +E+ ++ Sbjct: 3810 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 3857 Query: 2058 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 2117 Q ++ + A+ + A GK +G + + +Q + EA +Q+ E E Sbjct: 3858 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 3913 Query: 2118 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2177 R +AE ++K EE + L E++ + +EE R+ + + L Q Sbjct: 3914 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 3971 Query: 2178 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228 A + L +QK E EL + + VL + EA +A Sbjct: 3972 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4030 Query: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288 + E+ A EA+ + ++E + Q+ E+ + RK+ A R+A+ Sbjct: 4031 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4077 Query: 2289 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2342 + Q + E+H ++ +T +++ V E+ EET K+L+ Sbjct: 4078 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4135 Query: 2343 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2398 + Q L K+ T + + ++E+ SV ++ E K ++E E L + ++ Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4191 Query: 2399 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2447 Q F+ +AE+ VA + L + + A E + + + E K Sbjct: 4192 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4251 Query: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 +K V L + ++ + E+ R L +D + A+Q E LE Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4310 Query: 2508 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2564 + +LE++ + +++K ++A+ ++ Q+ + + +RT + +EK Sbjct: 4311 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4362 Query: 2565 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2622 +L D +L + ++EL + + + KS E Q +E LL Sbjct: 4363 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4404 Query: 2623 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2679 Q T ALQ +L + L ++ + + + L + A ++L + Q Sbjct: 4405 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4464 Query: 2680 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2723 R+ + S +++ + + +E R + + +LE RQ EE Sbjct: 4465 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4524 Query: 2724 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2760 LAE Q LR + L+ L +QH+ + EE A AT Sbjct: 4525 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4571 Score = 85.1 bits (209), Expect = 1e-15 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%) Query: 1263 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1317 EA++A + K+L+ +A+ + D+L EV L +E+ WR R Sbjct: 3342 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3386 Query: 1318 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 VA+ ER++ V + E++ + + + ++AD +W+ + ++ + + Sbjct: 3387 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3446 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434 L Q QL+ ++ EI RH + +++ + + + A + E Q + K +L+ V Sbjct: 3447 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3503 Query: 1435 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1480 + + QS + Y +L +E ++ SQ ETLR+ Sbjct: 3504 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3563 Query: 1481 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1540 +EE R + AE + + ++ + +L+ + + A L +++E+V + Sbjct: 3564 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3623 Query: 1541 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1592 R A +A Q +++ Q+ +S E ++ + RQ + +I+E+I Sbjct: 3624 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 3682 Query: 1593 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1645 + +LQ L T +QRG E R+ + + + Q++ +++ + +E + Sbjct: 3683 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738 Query: 1646 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1695 K +ELA + + + ++ Q ++ LE+ + Q +EA +R+ E++ Sbjct: 3739 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 3797 Query: 1696 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1750 ++ + + E E + + S E + + SL + EEA + Sbjct: 3798 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 3856 Query: 1751 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1803 A Q + +A + A +L + ++ Q EE+ Q KS A Q E E+ Sbjct: 3857 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 3916 Query: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863 +AE ++ + ++ Q L E +L L E ++ E L+ L Sbjct: 3917 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 3968 Query: 1864 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1917 Q + L+E LA L ++++ + +E ELAK +LA ++ E +++ Sbjct: 3969 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4028 Query: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977 ++ +E+ AG EEA+ L+ E ++ Q E +++ + + L + Sbjct: 4029 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4078 Query: 1978 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 2026 GE L+ TE + + E E+L + AF+ + ++ K Sbjct: 4079 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4138 Query: 2027 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 2077 ++ LA+ K++++ +++ VE L +R+ EE L L F + Sbjct: 4139 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4196 Query: 2078 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 2133 +AE L + S DT+ L + ++ A E RE + K+ Sbjct: 4197 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4249 Query: 2134 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2178 + ++++ L + V+RL + R+RA+Q E+ +L E Sbjct: 4250 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4309 Query: 2179 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231 ++K L +E +K Q KE Q++L + SV D + + A+ Sbjct: 4310 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4367 Query: 2232 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2283 + ++ + ++ R + VE +L+++ Q QA + L + Q A Sbjct: 4368 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426 Query: 2284 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2343 +Q ++ HK F ++ ++ + V+ + R +E + + + Sbjct: 4427 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4481 Query: 2344 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2394 ++Q L + L + Q EE L+ EAE ++ Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541 Query: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2446 D+D + + + E MK++ E+ A L+ A + + D + RA E Sbjct: 4542 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4601 Query: 2447 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2501 ++L K+ Q + A L A+ ELL+ Q L + +++ Q EE + Sbjct: 4602 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4661 Query: 2502 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2554 Q +E ++Q ++ + K R A+ S Q+ + A R R A + Sbjct: 4662 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 4721 Query: 2555 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606 +T++ T+ K V L ++R++ +L +A+ LE +E + + Sbjct: 4722 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 4775 Query: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647 + K ++ +++ + + + ++D + R+ FI+ Sbjct: 4776 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 4812 Score = 78.6 bits (192), Expect = 1e-13 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%) Query: 649 QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 701 QR +L+++ L L+ LL+W+ + + V + + V+AQ+ + L + Sbjct: 2970 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3029 Query: 702 IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 757 +++ ++ +E + + +++ PA + L LD ++ LLN ++ R R LE + S Sbjct: 3030 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3088 Query: 758 FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 811 VA E + WL E+ V + + + + + + AL ++ K + + Sbjct: 3089 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3148 Query: 812 LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 850 + G L + +R + Q+ L W +LQ C Sbjct: 3149 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3206 Query: 851 --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 899 E H K + Q +S + + + +L+ LQE L RK + D+ A + LE Sbjct: 3207 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3265 Query: 900 LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 947 L Q DE +++L K + +AK + +QL R H H Sbjct: 3266 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3325 Query: 948 AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 1001 + E V KG+E + + K L S +E + ++ LVP +E Sbjct: 3326 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3384 Query: 1002 AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 1056 E + + + LV T+ ++ ++L Q + SW T + L Sbjct: 3385 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3444 Query: 1057 --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 1100 EQ Q L+ L ++ + D +G E++ +++ Sbjct: 3445 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3504 Query: 1101 HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 1149 +Y + Q + + R Q +++ + +L T T + +L P Sbjct: 3505 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3564 Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1209 +E R+ + IAE + ++ G + LS + ++ E AA TL S+++ + Sbjct: 3565 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3622 Query: 1210 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1265 K L++ S S + +K+ I E L E+L++ ++ A + +++ Sbjct: 3623 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3672 Query: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1323 + K + E QP ++ L+ GE + R G ++D+ + ++++ Q++ Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 3725 Query: 1324 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1383 W+ + + R+ +L + + L ++D + ++ P D V++ Sbjct: 3726 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 3784 Query: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443 Q + + EEI+ E+++ + I A + + +V K ++ ++ Sbjct: 3785 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 3833 Query: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503 S +S+ + + D E QY + L+ + + +A + A ++ + Sbjct: 3834 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 3885 Query: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562 LE +Q E Q K++A ++ E+++ Q E++ ++ V + K ++Q+ L +L Sbjct: 3886 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 3942 Query: 1563 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1613 + S E I + + E A + + + + + L TE + GG ++ Sbjct: 3943 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4002 Query: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1672 A+ + Q E + + D + E AS ++ + E ++ Q L Sbjct: 4003 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4059 Query: 1673 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1730 + E+ + Q + A R+ + E+E +Q L +R L SK +TA+ + Sbjct: 4060 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4113 Query: 1731 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1770 ++ E A + +EE + Q+ + AR E E +L Sbjct: 4114 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4173 Query: 1771 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1830 + K EAL L ++ Q +AE+ A R + Q + A + Sbjct: 4174 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4233 Query: 1831 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886 + Q+ E GT + + +Q+++ ++ + + + + + L R A ++ Sbjct: 4234 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4293 Query: 1887 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1946 ++ +K+ ME L S+ + E ++ K ++ + + +E + ++ Sbjct: 4294 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4348 Query: 1947 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 2000 + R R L E+ + A + + +L+E G++ + + E AL Sbjct: 4349 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4408 Query: 2001 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 2059 + L+ L + + + E+Q D+ L KA EL ++ V+ R R+ Sbjct: 4409 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4468 Query: 2060 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 2119 + ++ S + ++ K +++ EL R L +Q LEAA ++ AEE Sbjct: 4469 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4514 Query: 2120 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2179 + + LA E+ R ++ + L+ +++ + ++ E++ A +L A Sbjct: 4515 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4573 Query: 2180 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2232 L K ++ + +E+ +Q Q Q A A A +E E Sbjct: 4574 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4629 Query: 2233 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2287 A + A + A++ ++ E + Q EE A+ Q E++ RK+ + + +R Sbjct: 4630 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 4688 Query: 2288 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346 A+ ++L+ D K+F +L + Q+E + + NLL + Sbjct: 4689 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 4740 Query: 2347 QRLKAEATEAARQRSQVEEELFSVR 2371 Q++ A E R+ + + L +R Sbjct: 4741 QQVWLLALERRRKLNDALDRLEELR 4765 Score = 69.3 bits (168), Expect = 8e-11 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%) Query: 1150 KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1206 K+ E Q +E + Q E+E RL+ +AE +L T++ EL+L Sbjct: 3892 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 3944 Query: 1207 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1262 LE+ R ++ + KL+ L + Q A + L A E L E + V + Sbjct: 3945 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4001 Query: 1263 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1322 E A L+ A Q T +A+ + + ++ GE E + ++ L Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4052 Query: 1323 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1381 +RWQ VL +T+ R+++L+ RQ + + + L WL D R + + PL + Sbjct: 4053 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4110 Query: 1382 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1422 +EQL +E+ +++ + + C + A+ Q IN +K+ E + Sbjct: 4111 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4170 Query: 1423 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1482 L K +LE + A + + +Q++++ T + + S+ + L +++ Sbjct: 4171 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4224 Query: 1483 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1542 E + A EV + E+ +L + K ++++ L + + V R Sbjct: 4225 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4273 Query: 1543 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1598 E V ++ RS+ + ++ +Q EA ++ ++E + S L I + ++ QL Sbjct: 4274 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4333 Query: 1599 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1654 + E Q+ GA+ + R + +K ++ + + +++D+ VE Sbjct: 4334 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4393 Query: 1655 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712 ++++ + + ALQAL + R++ + AE + +++ + + L ++ + Sbjct: 4394 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4449 Query: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1772 EL + +S L+RS +E + R+++ Q E RW+ Sbjct: 4450 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4492 Query: 1773 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1828 L ++ RL + + S+ A E EAE+ R G + R L + Sbjct: 4493 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4551 Query: 1829 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1887 Q E ++L E A+ A + + + + + AR + A A Q + Sbjct: 4552 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4611 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1940 Q L + LA + A+ E+L A A + + ++K K+ + E + L EE Sbjct: 4612 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4671 Query: 1941 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1990 R + ++ K ++ A + ++ Q RA +R A L G T+++T+ Sbjct: 4672 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 4731 Query: 1991 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 2029 +AL+ + N+ L RL E F R++ K+ + Sbjct: 4732 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 4791 Query: 2030 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 2088 + ++ K D ++ RQ+ ++ L + E+ A+ F++ G + + + Sbjct: 4792 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 4850 Query: 2089 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 2125 N + + ++E RQ+A + +R + E+ Sbjct: 4851 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 4887 Score = 64.3 bits (155), Expect = 3e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 527 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 586 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 Query: 587 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 Score = 40.0 bits (92), Expect = 0.054 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%) Query: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360 + E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R Sbjct: 712 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770 Query: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420 + E +F + Q KLK +E L+++ + EE Sbjct: 771 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810 Query: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477 + A+ LR + +++ Q +++ + +K++ V + AE L + E Sbjct: 811 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869 Query: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537 + + DK + + L + ++ ++ +RQ + E ++ K EM + + Sbjct: 870 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928 Query: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597 D +++A+++ E+ + ++ ++ + + L + I ++E + Sbjct: 929 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988 Query: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657 K+Q E + K+ Q QQ+ L+ E + ++QS + E +++ EQ A ++ + Sbjct: 989 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1039 Query: 2658 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2714 + + + + + QQ+ ++++M+ ++ + R R L Sbjct: 1040 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1085 Query: 2715 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2774 Q + + +RL E+ + LEE+ + + ++E+ +KTL + A P Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145 Query: 2775 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2804 ++ + +++ ++ LQ + A+ Sbjct: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1175 Score = 35.0 bits (79), Expect = 1.8 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%) Query: 501 LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 560 + V+ W K+ ++ER + L +R + +KL E L +++ L S++ Sbjct: 4267 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4319 Query: 561 RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 620 E+ D DK + + + Q +H + R L E+ Sbjct: 4320 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4365 Query: 621 IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 672 + NL+L ++ + + +SV+R+ +LE++ L LQ L+ W+ E Sbjct: 4366 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4423 Query: 673 QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 732 Q D G D+ V + +H+ + + + + ++ + +L +R D Sbjct: 4424 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4478 Query: 733 RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 778 + +Q +L L+ SK A LR E HS V A L WL E E+ + Sbjct: 4479 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4534 Query: 779 FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 825 F D + + + M++LE K ++ + GD +L HP Sbjct: 4535 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4583 Score = 35.0 bits (79), Expect = 1.8 Identities = 22/51 (43%), Positives = 26/51 (50%) Query: 4594 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4644 E +GL AA T+ S + S GS AGS+ GSR SR GS FD Sbjct: 5067 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5117 Score = 32.7 bits (73), Expect = 8.7 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%) Query: 642 QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 694 +V + V+R L+D+ R Q L+ W+EE++ +D E D ++ QL Sbjct: 4275 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4334 Query: 695 HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 749 H+ +S+ + + L T A D L L ++ + S R Sbjct: 4335 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4394 Query: 750 RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 801 LE F T L WL E E++ D N+ +++ A +E Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4451 Query: 802 LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 861 L + ++ L+ + L+ V+ L T+W + L + L+ Sbjct: 4452 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4511 Query: 862 FQFFSDVREA 871 + F V A Sbjct: 4512 AEEFHSVVHA 4521 >gi|20357504 dystonin isoform 1eB precursor [Homo sapiens] Length = 3062 Score = 787 bits (2032), Expect = 0.0 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%) Query: 655 EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714 E+ ++++QDLL WV+E Q ++D EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ Sbjct: 275 EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334 Query: 715 DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774 E Q++ + Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE Sbjct: 335 SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394 Query: 775 EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834 EEV +DWS+RNTN+ KK+ ++ LMREL+ KE+ IK +Q ++LL E+HPAR T+E+++ Sbjct: 395 EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454 Query: 835 AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894 AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA L+ L++A++RKYSCDRS+++ Sbjct: 455 AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514 Query: 895 TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954 +LEDL+Q++ +EKE+L +YK ++ L +AK ++QLKPR+ P++ +P+ A+CDY+Q Sbjct: 515 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574 Query: 955 VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014 +E+T++K DEC L + + WKV+S +G+EA VPSVCF VPPPN+EA + R+E Q+Q Sbjct: 575 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634 Query: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074 ++TLWH+ H++MKS+++W L ++ IR+ ++A+ +T+ P E +Q L +L+ ++ FL Sbjct: 635 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694 Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 DSQ++ F D E+E C +YQ+LL+S E+ QEES ISE+++IRL+LE Sbjct: 695 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 CE R + ++R PL+++ E RI EQ+K + E+E L + ++ + E+ + S Sbjct: 755 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814 Query: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254 + PTLRSEL + L + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A Sbjct: 815 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874 Query: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314 V A +E ++LK+ R++ + ++ F AL DEL+ A+ + + + + + ERD++ + Sbjct: 875 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934 Query: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374 +E+ QL+ERWQ V Q D R R+LE +G+ L+YYR++ PL W+Q Q +IQ Sbjct: 935 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994 Query: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1433 +S+ + QL Q++ L+ EIE K++ECQ++A+QY +KDYELQ +TY+A ++ Sbjct: 995 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054 Query: 1434 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1493 SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF ++L+R+EEEE+ E+++ Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114 Query: 1494 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1550 E VE A E Q+ ++ K AE+ K Q+ EE+ ++E +A Q Sbjct: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167 Query: 1551 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1591 ++ ++++++ L++S +Q + ++ S +++EE++ Sbjct: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225 Score = 124 bits (312), Expect = 2e-27 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%) Query: 3798 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3856 E+YNLL E + L+E+ + +AG + + LS++QA+ +GL+ + Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256 Query: 3857 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3914 LLE Q L+ P + + +A GL+ ++ +L LS + + P Sbjct: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313 Query: 3915 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3974 TI + A+ + +I A+++L+ L+TG +V P G L L+ A+Q+ ++ ++ Sbjct: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373 Query: 3975 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 4031 E + + +DP T E++S +++R + TG LLP+ + ++T + + I++ Sbjct: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432 Query: 4032 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 4091 ++D T +L + L G G+ + +R++V +A++ Sbjct: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475 Query: 4092 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 4151 +G+I TA +L Q TG +I +LTV+EAV+ ++ +L A+R G Sbjct: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535 Query: 4152 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4211 P+SG++ ++++ LI + ++L + + PE S + ++ A + G+ D Sbjct: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595 Query: 4212 EMNEIL 4217 IL Sbjct: 1596 NTASIL 1601 Score = 119 bits (298), Expect = 7e-26 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%) Query: 2301 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2360 + E+ K++ ++ L+ + EQE + L + E + + L+ RL + +R Sbjct: 712 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770 Query: 2361 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2420 + E +F + Q KLK +E L+++ + EE Sbjct: 771 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810 Query: 2421 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2477 + A+ LR + +++ Q +++ + +K++ V + AE L + E Sbjct: 811 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869 Query: 2478 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2537 + + DK + + L + ++ ++ +RQ + E ++ K EM + + Sbjct: 870 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928 Query: 2538 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2597 D +++A+++ E+ + ++ ++ + + L + I ++E + Sbjct: 929 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988 Query: 2598 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2657 K+Q E + K+ Q QQ+ L+ E + ++QS + E ++ ++ + Sbjct: 989 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046 Query: 2658 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2710 + V Q+ +++R Q Q+ R R A + + A + ++R +EE Sbjct: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106 Query: 2711 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2763 + LE+++++ E E + + + L++ +A SEE++ + ++ L Sbjct: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166 Query: 2764 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2822 + L + E + L ++V LQE+ +L +E L++L + T+ Sbjct: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216 Query: 2823 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2882 DV+ + IAG + + T E LSV+ A+ R L+ T + LLE Q L+ P Sbjct: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276 Query: 2883 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2940 + + +A G++ ++ +L LS + + P T I + A+ + +I I Sbjct: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333 Query: 2941 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 3000 ++LE ++TG ++ P ++ + A+++ + + + + K DP T E ++ Sbjct: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393 Query: 3001 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 3060 + +++R TG+ LLP+ + +GG + G+ ++ Sbjct: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431 Query: 3061 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 3120 I LR G I E + +++ + Sbjct: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451 Query: 3121 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3180 A+LL +I+ Q++ E V + DT L G+ ++L++ A Sbjct: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511 Query: 3181 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3240 ++ DL+ S A+ +LEAQ G +I P + +++ L+ E K+L+ + + Sbjct: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571 Query: 3241 GYRDPYTGQSVSLFQALKKGLI 3262 P + Q + L A + G+I Sbjct: 1572 ALYIPESSQVIGLDAAKQLGII 1593 Score = 109 bits (273), Expect = 6e-23 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%) Query: 2050 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 2108 VE L + V I ++S ++A + ++ L + L S+ L +R Sbjct: 308 VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367 Query: 2109 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2166 +R L R E + + EEE A + R K E R ++ E Sbjct: 368 QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427 Query: 2167 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2221 QE A QL L A+ ++A + A+Q + + Q Q + + + E Sbjct: 428 NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483 Query: 2222 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2281 A +EA R +++A + K S + R+ + E L +E+ + Sbjct: 484 FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526 Query: 2282 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341 E Q + A ++ + ++ L+ ++ ++++ + + Sbjct: 527 EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586 Query: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401 L R K + + V F+V +E L RIE + + N Sbjct: 587 LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638 Query: 2402 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2453 E MK V + R S A L ++ L+ ++ E L++ Sbjct: 639 LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698 Query: 2454 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2509 ++ + T+L+ E + +Q + + A R +E +E + E + + LE Sbjct: 699 ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757 Query: 2510 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2540 R Q ++ E ERLK + ++ +QA A Sbjct: 758 DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817 Query: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2600 R + + + +++ + + ++T+ + + + + EA+ +L E + + Sbjct: 818 PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871 Query: 2601 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2656 +EA + + E +Q E +Q F + +D L Q+ + I E K + Sbjct: 872 EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930 Query: 2657 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2713 F KA QL E Q Q++ + L S++ R H ++ +++ + +++ Sbjct: 931 FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990 Query: 2714 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2757 ++ + + + LA E Q ++ Q EQ+ A + E T + V Sbjct: 991 QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050 Query: 2758 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2811 + + P R + A E F LR + +A Q ++ AG + L+RL + Sbjct: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104 Query: 2812 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2860 +++E + E + + S+I+ L A + +K+S + +++ LS Sbjct: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164 Query: 2861 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2901 I L + D RN L +E++K+ G V ++ Sbjct: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222 Query: 2902 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2961 KL ++ + G D TG+ +S+FQA+ +GLI + GIRLLE Q+ G+I P Sbjct: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279 Query: 2962 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 3021 + A G DE++ L + S + + + T + +L+ + T + + Sbjct: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335 Query: 3022 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 3076 + G LV + + +KA SA F K + ++I+ Sbjct: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395 Query: 3077 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 3136 D+++ R T+++ + + V QE GR+ + R+ + +IDRE Sbjct: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444 Query: 3137 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3196 T+ R L + G+ +GQ++++ A+++ ++ D A ++L Sbjct: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489 Query: 3197 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3256 Q TG II + RLTVDEAV+ L+ +L A++ G P++G+ + Sbjct: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549 Query: 3257 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3308 L++ LI E ++L+ + + P S + LD A G +D T+ L Sbjct: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601 Score = 90.5 bits (223), Expect = 4e-17 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%) Query: 3902 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3961 ++ + G D T + +S+FQA+ + LI + +RLL+ QL G++ P L L+ A Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285 Query: 3962 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 4020 G +++ QL E S+ + + ++ + L + + ++L L L Sbjct: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345 Query: 4021 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 4080 +Q+T+++ + ++ A K LE + + T Sbjct: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388 Query: 4081 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 4140 E++S+ +++ ++ T LL + G I G +++ A G++ E + Sbjct: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448 Query: 4141 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4200 LLSA+ G + SG+ +++ +A+++G+I +D +L Q+ TGGII + RL V Sbjct: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508 Query: 4201 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4259 + A + L ++ + G P++ E T L + IT+ L Sbjct: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564 Query: 4260 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4304 + R++ + PE+ + + + A + G+ID+ T Sbjct: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597 Score = 90.1 bits (222), Expect = 5e-17 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%) Query: 4145 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4204 ++ + G D +G+++S+FQA+ +GLI D GIRLLE Q+ G+I PE ++ A Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285 Query: 4205 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254 GL DE++ EI++ S T D + +T ++ TG Sbjct: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345 Query: 4255 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4302 ++P L++ ++ SS S V +R+ + ++DP T +++S+ + ++ + Sbjct: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405 Query: 4303 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4362 T + L + + +G I + GR I A + LIDR + + + Sbjct: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451 Query: 4363 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4422 A +LSG G+++ Sbjct: 1452 -------AQLLSG-------------------------------------------GLIN 1461 Query: 4423 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4482 + + +++++ EA+ ++D T +L Q TGGII + +R V +AV L+ Sbjct: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521 Query: 4483 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4542 + AQ+ + G P + + +L++ + E + L + L P++ Sbjct: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581 Query: 4543 VPLDEALQRGTVDARTAQKLRDV 4565 + LD A Q G +D TA L+++ Sbjct: 1582 IGLDAAKQLGIIDNNTASILKNI 1604 Score = 88.2 bits (217), Expect = 2e-16 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%) Query: 3236 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3295 +K + G D TG+ +S+FQA+ +GLI + G+RLL+ QL G++ P L A Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285 Query: 3296 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3355 + G +DE+ L + +KA S P T +P+ + A+ Sbjct: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324 Query: 3356 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3413 + E + + +P G + ++ L+SS F+ ++ + + Sbjct: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384 Query: 3414 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3470 T EKV LI +V+ + +R L G + RA E L D Sbjct: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442 Query: 3471 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3530 +T + LS LL G G+ ++ +++++ EA+R G++ TA+ +L Q Sbjct: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492 Query: 3531 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3590 TG ++ +RL V EAV+ ++ +L A++ G P+SG ++Q+ Sbjct: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552 Query: 3591 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3648 L+ + ++L + + P S + +D A Q G +L + + D Sbjct: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612 Query: 3649 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3704 D +N R+ L C P T + E TTQ T EET++ F Sbjct: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664 Score = 85.9 bits (211), Expect = 9e-16 Identities = 88/421 (20%), Positives = 179/421 (42%), Gaps = 39/421 (9%) Query: 3459 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3518 +L +QL++ +T+ G V+ + +AG + T E +S+++A+ RGL+ Sbjct: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253 Query: 3519 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3576 T LLE Q L+ P + + +A G++ ++ QL LS K + P Sbjct: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313 Query: 3577 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3636 +TI + A+ + ++ I++LE ++TG ++ P ++ + A+Q+ S + Sbjct: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370 Query: 3637 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3696 + + + K DP T E ++ +++R TG+ LLP++ E + T + Sbjct: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRI--TLKCGR 1428 Query: 3697 EEETRRAFEETQID------------IPGG--GSHGGSTMSLWEVMQSDLIPEEQRAQLM 3742 RA E ID + GG S+ G M++ E ++ +I + + ++ Sbjct: 1429 NISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSIL 1488 Query: 3743 A-DFQAGRVTKERMI--IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLET 3799 Q G + + + + E ++ I L + R + +I + Sbjct: 1489 TYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYV--------GLIWPHS 1540 Query: 3800 YNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARL 3859 + + +E + E A+ L G +A +Y+P S Q + + A + G++ A + Sbjct: 1541 GEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASI 1600 Query: 3860 L 3860 L Sbjct: 1601 L 1601 Score = 81.3 bits (199), Expect = 2e-14 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%) Query: 4117 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4174 + + T+++A + G P F + +S+E T K+ S L I LF A K G + D Sbjct: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182 Query: 4175 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4232 LE Q+ T +ES+ L + K+ + ++ + D G D T Sbjct: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237 Query: 4233 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4292 E L+ Q + R + D TG+ LL +T S ++ PE K + Sbjct: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282 Query: 4293 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4352 +A GLID Q +L E E I+ +S + + DA+A+++I Sbjct: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328 Query: 4353 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4412 S ++I +LS + + + ++ + S A +S E Sbjct: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375 Query: 4413 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4472 ++D T EKVS+ + + R+ + TG LL + GG I G + A Sbjct: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435 Query: 4473 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4532 ++GL+D+ + R+ AQ G + + +M+ +A+++G + + L Q TG Sbjct: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495 Query: 4533 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4592 G+I+ + R+ +DEA+Q + + +A + + L P + +L + ++ Sbjct: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555 Query: 4593 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4629 ++L Q Y P S G A + G Sbjct: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591 Score = 72.0 bits (175), Expect = 1e-11 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%) Query: 3162 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3221 VIAG + G+ LS++ A+ + L+ D + LLE Q +I P + +A Sbjct: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287 Query: 3222 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3279 GL+ + K LS K + P T + + AL + +I +++L+ LSTG Sbjct: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344 Query: 3280 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3339 +V P+ ++ L A + + + + K DP T E + ++ QR Sbjct: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404 Query: 3340 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3383 + TG+ LLP+ + RA E L RET F ++ GG Sbjct: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460 Query: 3384 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3429 G+ +TV E + + +L Q +TG ++TV++ ++ LIT Sbjct: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520 Query: 3430 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3489 + L +R + GL P S L ++L + K +L Sbjct: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565 Query: 3490 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3525 G +A +Y+ ++ + + + A + G++ TA++L Sbjct: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601 Score = 64.3 bits (155), Expect = 3e-09 Identities = 34/98 (34%), Positives = 61/98 (62%) Query: 527 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 586 RLE LQ+I ++Q ++ +CE++L A LQSD + L +G Q E+ + + ++++ Sbjct: 56 RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115 Query: 587 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 624 R DVQ L DG++ Q +Q+ +RV +L + ++A+R E Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153 Score = 48.9 bits (115), Expect = 1e-04 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%) Query: 1693 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747 E++R R VA L + + LQS+ F E + + + + + QL +E Sbjct: 659 EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715 Query: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807 Q E ++ E E+E + L +E +RL+ E + + + Q ++++ Sbjct: 716 NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773 Query: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1864 E+ R +E+ ++ E + +L E Q AA + LR+E Q Sbjct: 774 HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832 Query: 1865 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1920 Q + + + Q EA L K+ E E ++A K E ST + Sbjct: 833 QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890 Query: 1921 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1980 + + ++ + F L +E + +A+++E + + + D + +A+++ + Sbjct: 891 QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943 Query: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040 + + + L++ E + L + D +Q + I+E + K Sbjct: 944 RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002 Query: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100 ++L +QK LV + ++ +++E + E+ +A + EL+ R+ + +S Sbjct: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056 Query: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160 ++R++ + + +E + + A + K A + ++RL+ EE + Sbjct: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108 Query: 2161 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2208 L E ++ E A++LQ K L+ EKA + + K+++L + LQ Sbjct: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168 Query: 2209 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2266 Q L A+ + +E R + E++ Q + +E LKQ E Q Sbjct: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219 Query: 2267 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2325 + + +K + +Q QA LR D Sbjct: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255 Query: 2326 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2385 T +RL LE L+ EL+ K + A+ ++E++ Q++ELSK K I Sbjct: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309 Query: 2386 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444 A + I + D + A K+ ++ L + A Q A + AL Sbjct: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369 Query: 2445 AEKMLKEK 2452 K+L+ + Sbjct: 1370 FSKVLERQ 1377 >gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] Length = 2390 Score = 427 bits (1097), Expect = e-118 Identities = 551/2242 (24%), Positives = 905/2242 (40%), Gaps = 310/2242 (13%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233 DER+ VQKKTFTKWVN HL + + DLY DLRDG NL+ LLEVLSG+ LP+ KGRMR Sbjct: 53 DEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILPKPTKGRMR 112 Query: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292 H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI DI V + Sbjct: 113 IHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQDISVETEDN 172 Query: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351 E +AK+ LLLW Q GY + NFT+SWRDG FNAI+H+H+P L+D + + Sbjct: 173 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLDFESLKKCN 232 Query: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410 NL AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y ++ + +G R Sbjct: 233 AHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMKALAVEGKR 292 Query: 411 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463 A E + ++Y L LLQW+ +R+ +S ++ F ++ Sbjct: 293 IGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQLQSFNSYRT 352 Query: 464 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520 +E P K +K + + +++ ++A KV G D+ K W +L A ERE Sbjct: 353 VEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEKAEHERELA 412 Query: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577 LR+E R E L+++ + +A + E L++ L+ D + L A ++ +E Sbjct: 413 LRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAVRKHEAIET 472 Query: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 637 D I VQ + + Y + R+ R + ++ + A Sbjct: 473 D-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLRQMVAARRE 525 Query: 638 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 697 + + LQ V + L YL D W+EE + R+ + G L VE L Sbjct: 526 RLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVEDLL----Q 571 Query: 698 LHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY---AKLLN 743 LH+ +E + + ER R+ L G YR C + +L+ Y +L Sbjct: 572 LHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSYEALCELAA 631 Query: 744 SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELE 803 + +ARL L F+ + W+ E++ D T ++AL E+ Sbjct: 632 ARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKHTALRGEMS 691 Query: 804 LKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQ 863 + +K G +L+ E HP + A LQ QW + L L + A+ +Q Sbjct: 692 GRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLAQAASLYQ 751 Query: 864 FFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 923 F +D + E L +ALR S + + L + + +E++ ++ L L + Sbjct: 752 FQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHRPTLDALRE 808 Query: 924 RAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSG 983 +A A+ R P ++GR+P L H++ L + Sbjct: 809 QAAALPPTLSRTP--EVQGRVPTL-------------------------ERHYEELQARA 841 Query: 984 SEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAWQSLRRDVQ 1041 E A A EA L LW + + LA D++ Sbjct: 842 GERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLE 888 Query: 1042 LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1101 +++ F TL+PE A ++ A + G +DR++ +E +H Sbjct: 889 VVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQE--QLNHR 939 Query: 1102 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIA 1161 +QQ + L G + S L LE ET+ R Sbjct: 940 WQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR------------------ 975 Query: 1162 EQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIY 1221 E+ K +GLG +A + A K+ A EL + +L+A + Sbjct: 976 EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TREANALAAGH 1029 Query: 1222 LEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV---------------------- 1255 + I+ +R Q E LRA EE L EA+ + Sbjct: 1030 PAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTAVA 1089 Query: 1256 ----PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEV 1311 PATLPE EA A LR + E Q + LR +GE + + + D + Sbjct: 1090 SEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR--DQADPQC 1140 Query: 1312 ERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQ 1371 R+R+ L W+ + + RQ L Q A +L+DAR+ + + Sbjct: 1141 LFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDARQAEGVLS 1189 Query: 1372 AMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1423 + S QA +++ + + ++ +GE++ +Q ++ E + Sbjct: 1190 SQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS-----EGNI 1244 Query: 1424 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1483 K + + + + K Q ++ + D R Q+ L+ + Sbjct: 1245 HADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDCHELKLWID 1295 Query: 1484 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREE 1543 E+ L Q + + R + +K + A K ++ KE E Sbjct: 1296 EKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE-----------GRE 1342 Query: 1544 AAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE----EIRVVRL 1596 ++ + K + E+L+ L + E QAKAR A R+ L + E + L Sbjct: 1343 LTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCALESWLESL 1402 Query: 1597 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELA 1655 Q + G + L + + E + ++E E ++ Q + +Q + A EVE Sbjct: 1403 QAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERT 1462 Query: 1656 SRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1712 SR A EK RAL Q + E RLQA + + + + V L A Sbjct: 1463 SR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEH 1516 Query: 1713 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAERAREEAERE 1767 + +K L++ +Q +A LRE A + AE + + E Sbjct: 1517 GKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE 1576 Query: 1768 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1827 LE + +ALR AQQ AEAE E E + KA+++ Q E+ Sbjct: 1577 LELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVK 1628 Query: 1828 E-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ------------GEQQR 1866 + Q LE+ T Q A+ Q++I R+ Q GE++ Sbjct: 1629 KHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRE 1688 Query: 1867 QLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEESRSTSEKSK 1923 +L E L +L+RE Q QE E A ++ + E + + + E SR TS + Sbjct: 1689 RLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQ 1748 Query: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983 +R+++ L RA E K A D E + LAA E Sbjct: 1749 ERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQVLAAAYELQ 1804 Query: 1984 RLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKA 2038 R A AL + + ++L R L EA QRR ++ DI+ Q+++ Sbjct: 1805 RFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQALSPQVQQV 1859 Query: 2039 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 2098 D QK D + + + + A + ++A + +L L+ D R Sbjct: 1860 QDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD-------TTDKFRF 1912 Query: 2099 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 2158 +A R+ L +E + +A+ER + +A+ Q+ E ++A+ + Sbjct: 1913 -----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE----IEARADRF 1963 Query: 2159 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2218 + ++ AR A+E ++K Q + + Q+ ++ Q+ + Q VL+ L Sbjct: 1964 SSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQLVLEVLVF 2018 Query: 2219 EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKE 2278 +A A + + E + +VE + ++ ++ A A + A EKL Sbjct: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFCALEKLTAL 2078 Query: 2279 AEQEAARRAQAEQAALRQKQAA 2300 E+E R+ + E+ R++ A Sbjct: 2079 EEREKERKRKREEEERRKQPPA 2100 Score = 123 bits (309), Expect = 4e-27 Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%) Query: 1303 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1362 R G ++ + ER+ + + L +RQ +LEQL R+ R++A WL + Sbjct: 387 REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443 Query: 1363 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1421 +R Q + LA AV +R+ +A+ +I + +V+ A + + A + +++ Sbjct: 444 NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499 Query: 1422 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1481 + + + + V + E ++ ++L+ + +L L +++ + L+ Sbjct: 500 KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557 Query: 1482 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1539 + LA + + L E + A++ +R A A A +E + Q + E V Sbjct: 558 DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617 Query: 1540 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1584 + E EA + +R+ EE ++L + +EA ++ + +A+ R Sbjct: 618 KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677 Query: 1585 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636 LR E R+ L+L + Q+ AEG A +A A AE Q + ERL Sbjct: 678 RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732 Query: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1686 ++ +QR QA AS + +A+A + + AL +E QA + Sbjct: 733 EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788 Query: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746 R + E+ R AL Q +A S+ + LER +E + Sbjct: 789 HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847 Query: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1798 E A E+ Q AL RL+ EV QQ+ + A+ Sbjct: 848 LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907 Query: 1799 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1848 + AE+ + +++ V +E ++ R+LA+G L Sbjct: 908 ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967 Query: 1849 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1896 + +R +T+ E + L L+ +LA +R+ A + EL E LA Sbjct: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027 Query: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1955 V + ++ R + + +R E G R L + L A + Q Sbjct: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087 Query: 1956 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 2011 +A E+ EAE +LA+ A GE R ++E RLR L E D+A Sbjct: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136 Query: 2012 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 2051 F R+RLE E+ + + RLAQ LR A +E L Q+ ++ Sbjct: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196 Query: 2052 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2111 T ++ + A A+ +K + ++ RI E + + + A + R+ Sbjct: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251 Query: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2171 A ERR ++ ++ Q+ L + R+++ L++ LK ++E + + AR Sbjct: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310 Query: 2172 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2218 L +A+ AA K + + ++ EL+ + ++ L D+L Sbjct: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370 Query: 2219 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2272 +A R+ +A A + A+ A + Q+ + K + Q Sbjct: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430 Query: 2273 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2332 E +E E EA QA+ AL Q+ E+E+ + E+ R Q +E RLQ Sbjct: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486 Query: 2333 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2392 HQ + VE+E+ V ++ S ++ + + L+ Sbjct: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526 Query: 2393 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2450 ++ Q+ +Q ++ + E L AA E A L+++ + L + L K L+ Sbjct: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585 Query: 2451 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2510 + ++A Q+ R AEAE ++EL M Q+ A++ Sbjct: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619 Query: 2511 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2570 E+SA+AE K +V E + A + + +H+ ++Q+ + Sbjct: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660 Query: 2571 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2626 + ++L + EL E+ E+LQ+ +L QL+ E Q +Q+ +++ + Sbjct: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720 Query: 2627 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2686 L Q + + + R++F E + + Q+ V A L L+ Sbjct: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762 Query: 2687 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2746 A AR E ++ + +L +L R Q +LA + LQ R AL Sbjct: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814 Query: 2747 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2806 A + T N +AL EH L +V Q++Q+ G L Sbjct: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866 Query: 2807 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2862 Q+ G +E+ R + LQG S+ LL T +K + A++ +L Sbjct: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925 Query: 2863 ALILLEAQ 2870 + ++AQ Sbjct: 1926 VNLQMDAQ 1933 Score = 122 bits (307), Expect = 6e-27 Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%) Query: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320 EL A +A+++K EA + A ++ V L ER +++R R Sbjct: 456 ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508 Query: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380 + W L Q +RE L +L+ + L W+++ + R +Q+ L A Sbjct: 509 VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564 Query: 1381 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1439 E L Q L+E +I E+V A ++ N K+Y +P + Sbjct: 565 GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616 Query: 1440 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1484 K++ E++ + R E L Q++ ++T R + Sbjct: 617 AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676 Query: 1485 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1540 RL + R E RL ++ LE+ +QL AE H A +QA A ELQ + + Sbjct: 677 LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735 Query: 1541 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1590 EE A Q Q + + LR S E+ +A R +EEE Sbjct: 736 AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795 Query: 1591 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1650 IR R L+A Q L +R E + + + E L+ + +R R Sbjct: 796 IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848 Query: 1651 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1694 E LA + +EA A EK++ L + LE+L R + E E A++ Sbjct: 849 EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908 Query: 1695 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1754 + L A + + + + + Q R + A+ + + Sbjct: 909 TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967 Query: 1755 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813 E + E + +E Q N+ A L LQ + ++ L A + E A Sbjct: 968 TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027 Query: 1814 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1867 G + L E + + A ++ E Q+ +R + + G Q Sbjct: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087 Query: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1923 + EE EA A + L E+ + ++E L +A EE +R ++ + Sbjct: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144 Query: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1979 QRLEA + EL RQ +LA+ + R +AE VL+ + + Sbjct: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195 Query: 1980 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 2027 T A+ A+K+ E A ER+ L E + + + KAD Sbjct: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255 Query: 2028 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 2070 IE R + + A+ L R Q+ ++D + ++E++L L Sbjct: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315 Query: 2071 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 2126 ++K A AEL L ++ + E TL E L + + R L RR E E Sbjct: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371 Query: 2127 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2180 Q + +A R Q ALE +E L+A++ + + L Sbjct: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422 Query: 2181 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2240 +K+ E + AV++KE E Q + + DQ GE E RA EE A Q RE Sbjct: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479 Query: 2241 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2300 + + E + + E+ + E+L + E + + Q +++ Q Sbjct: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533 Query: 2301 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2352 E++ H+ + A+ RQ+ A EL L+ + H+ L + L+ R + Sbjct: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593 Query: 2353 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2409 +AA + + E+ + Q + +L A+ E + ++ L D T L ++ Sbjct: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653 Query: 2410 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2459 M E+ R+S+ + A L++LA E L + L + + L + Q +QE Sbjct: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713 Query: 2460 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2513 + A EL Q + + +++ R D + Q+ + L A R Sbjct: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773 Query: 2514 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2566 E + E+ +R Q A + QRF R+ + K + T + Sbjct: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833 Query: 2567 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2620 + L+ + +HD + L + +++ + +LQ+ K+EE MQ V + Q Sbjct: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891 Query: 2621 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2673 L + A +Q L D RE + ++ L+ Q+ +V+ A + + QQ Sbjct: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951 Query: 2674 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2730 + ++E R + ++ E R H A E + E+L QL+ +R++ E E+ Sbjct: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008 Query: 2731 LREQLQLLEEQHRAALAHS 2749 L+ L++L A +A + Sbjct: 2009 LQLVLEVLVFGRDAGMAEA 2027 Score = 115 bits (288), Expect = 1e-24 Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%) Query: 1285 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1340 ALR E+ G + E+ QQ E + R A+L +W+ + A + R + L Sbjct: 685 ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744 Query: 1341 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1399 Q L ++ A+ + AWL DA R + + L + + L RQ +AL EEI H Sbjct: 745 QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800 Query: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459 ++ + A A L P S + P+VQ ++ + Y +L+ Sbjct: 801 PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840 Query: 1460 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1509 E + + +EE+E+ LA +R E+ E + + LE + Sbjct: 841 AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900 Query: 1510 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1567 A A + + ++ +V +E QQ R + + + S S Sbjct: 901 MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960 Query: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1624 + + +A R + ++ E + + L A +R+ G E +L+A+ AR E Sbjct: 961 QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019 Query: 1625 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1683 R+A LA+ A+A A + R +Q E+LR Sbjct: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051 Query: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743 A R R+ + AR++Q L + + + R A + + +L E +AQ Sbjct: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106 Query: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803 A + E ERA+ E R LR EEV + ++ Q +Q+ Sbjct: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146 Query: 1804 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863 EA G E+ R E +Q +LA+ Q + +AE Sbjct: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190 Query: 1864 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1923 Q+ L E+ + A AA +K ++ + + + LL + + E ++K + Sbjct: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250 Query: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1983 ++ ++ R ++ + A + + + Q+ ++ + E++L + + EA Sbjct: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310 Query: 1984 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040 L T+ + + E A + L ++ ++ R L + + KA + E+L L + D Sbjct: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366 Query: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 2100 ELE T + R + + A +A + E LE + + +++D + Sbjct: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416 Query: 2101 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2160 + +Q+ L E R +E E ++ A+ +A Q EVER VEE R Sbjct: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471 Query: 2161 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2200 + +E R+LQ ++E Q E++ + +K Q Sbjct: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531 Query: 2201 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260 LQ+ +Q + + LR A AA E A +Q +R E E + E+ Sbjct: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586 Query: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2320 +A+ + AAE EQE Q + + + +A AE++KH+ EQ L AQ Sbjct: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642 Query: 2321 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2373 +L + + +H ++ + ++ +L A E A R+R Q L +R + Sbjct: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702 Query: 2374 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2415 +++L + + + A + L +LRDK +T QE + +A Sbjct: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762 Query: 2416 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2452 AAR +VA Q A +L ++ALA ++ K Sbjct: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820 Query: 2453 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2501 Q + + T A Q++ A E Q +++Q+D ++ + A E G Sbjct: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880 Query: 2502 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2555 AE QL+ S+ A R L L + R E D + A+E + Sbjct: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940 Query: 2556 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2601 +L + + + +E + + S + AE + E +++L+ + Q+ Sbjct: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997 Query: 2602 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2656 A+ Q K + +Q V + + + +++L ++ L++ +++ ++ K + Sbjct: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057 Query: 2657 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701 FQ ++ ++ E+E++R EE RR+Q A E Sbjct: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102 Score = 108 bits (270), Expect = 1e-22 Identities = 320/1501 (21%), Positives = 539/1501 (35%), Gaps = 266/1501 (17%) Query: 1442 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1501 V E I YV HY + K I + L E ERL E+ + E L Sbjct: 261 VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320 Query: 1502 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1550 +E + RQLA + + + Q E+ K ++ E ++ ++ + A Sbjct: 321 IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380 Query: 1551 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1576 QK R I QE+L+QL ++ + +A R+ Sbjct: 381 QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438 Query: 1577 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1629 +E RL ++ + +EA R+ E G +QA+ A A E A++ Sbjct: 439 TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498 Query: 1630 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1684 + + V RQ R+ E + Q L ++ + RLQ+++ Sbjct: 499 IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558 Query: 1685 AERRLRQAE----------------VERARQVQVA----------------------LET 1706 R L E ER R V + + Sbjct: 559 LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618 Query: 1707 AQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------ 1758 ++S EA EL + R + E++ +L R L E A A +RE+ A + Sbjct: 619 LEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR 678 Query: 1759 ------RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1812 R E L +L + +L + A Q S AE + Q E E A Sbjct: 679 LLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEE 738 Query: 1813 RGKAEEQAV------------------RQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854 R + QA R ++ EL + A+Q A E+E+ Sbjct: 739 RAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798 Query: 1855 LRAETEQGEQQRQLLEEELAR---LQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1911 R + +Q L L+R +Q + +EL+A + +E LA Sbjct: 799 HRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTML 858 Query: 1912 EE---------------------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE- 1949 E E E +QR E LA + + +AE+ Sbjct: 859 SEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918 Query: 1950 -----AKRQRQLAEEDAARQRAEAERVLAE-KLAAIGEATRLK------TEAEIALKEKE 1997 + R + ++ R + R LA+ K AA+ A ++ TE + ++EK Sbjct: 919 LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978 Query: 1998 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQ 2056 E + L D A A Q K ER + A EL R+ L Q Sbjct: 979 KVIESTQGLGNDLA------GVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQ 1032 Query: 2057 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 2116 + + ++ +E A E LG R +D LRS + + R + A E Sbjct: 1033 AVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVASE 1091 Query: 2117 E--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------LRERA 2165 E EAE + + A E R A E RL+A EE R LR+R Sbjct: 1092 EGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147 Query: 2166 EQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QLRGEA 2220 E +L + E+ Q RL +AH F + ++ + L ++ VL ++ G Sbjct: 1148 EALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTL 1204 Query: 2221 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2280 +AA A ++ E+ + ER+ E Q ++ A+K+R++A+ Sbjct: 1205 QAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIREKAD 1254 Query: 2281 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2340 RR + Q A +Q + + + F + K +++++ T Q D +N Sbjct: 1255 -SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYDEARN 1311 Query: 2341 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2400 L + Q+ +A E A + +++ R E +LKA + + LRD Sbjct: 1312 -LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDLHRRW 1365 Query: 2401 RFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKMLKEK 2452 L+ + + +A R + AQ L QL +D + +LK++ Sbjct: 1366 DELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQ 1425 Query: 2453 MQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQRTLE 2506 E + E E +Q Q K LAQE + R E+ + L + + R L+ Sbjct: 1426 QMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ 1485 Query: 2507 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2566 A R+ Q + + E L V E + E G+ L +L ++ T Sbjct: 1486 ASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMKKNQT 1532 Query: 2567 LVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2618 L + + +++ +Q A +AEL+ ++L E L+L+ + ++ + Sbjct: 1533 LQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLEDALR 1589 Query: 2619 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2678 Q A ++++ E Q + QEKAK E Q EV K Q L + Q + Sbjct: 1590 AQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTI 1644 Query: 2679 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2738 Q L AS ++ +H + +Q ++ +L + EL E +RL+E L+L Sbjct: 1645 HQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEHLRLC 1697 Query: 2739 E 2739 + Sbjct: 1698 Q 1698 Score = 77.4 bits (189), Expect = 3e-13 Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%) Query: 1110 EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1167 E+ E R Q + L D + L +T ++ PA E +A+ + Sbjct: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111 Query: 1168 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1221 EVE +RL A E+V + P LR LE LG++ + R Sbjct: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167 Query: 1222 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1281 L + +R + AE VL + E L + +P TL +A A++KKL E Sbjct: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219 Query: 1282 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1341 T DA + + G E G +L E ++ ++ RE+ + R + D Q+ L + Sbjct: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273 Query: 1342 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1399 L R+ +++ + L W+ + + Q + +++ + + ++ QA + E+ + Sbjct: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329 Query: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1453 K +++ + +L K +L+ + S + ++++ +++ + Sbjct: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379 Query: 1454 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1510 D +++ +++ + L + + L +++++ E E A+ EK+ Sbjct: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439 Query: 1511 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1557 + +A A+A AQ ++ A E+++ + E RR +A+ + Q R +++ Sbjct: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499 Query: 1558 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1612 E+ ++L +S E + + +++EI+ ++ + ERQR L Sbjct: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554 Query: 1613 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1671 A A E AE Q E +RL +++ +R A + R AEAEA +Q Sbjct: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609 Query: 1672 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1724 +A +EL QAE + + L QA + A+ + ++Q + E +S R S + Sbjct: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669 Query: 1725 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1771 + A R +EH+ + QLR E + Q Q+ E A E ++ E Sbjct: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729 Query: 1772 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1812 + ++ + Q++ +LA AE + EA + Sbjct: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789 Query: 1813 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862 RG+ A QR L A Q L KQ+QL +GT + AAE L R E Sbjct: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848 Query: 1863 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1918 Q Q Q ++++ RLQ+ A A K +E+ + V L S A + T Sbjct: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906 Query: 1919 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1978 ++K + +A R L + L+ A+E R A+ Q+ + A A Sbjct: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960 Query: 1979 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 2034 ++ + E+ + A E +L++ +A RR+ + Q K D + E L Sbjct: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018 Query: 2035 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 2091 R A +E L Q+ LV L E ++ +F+K+A E R Sbjct: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070 Query: 2092 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 2138 A + L + E+ E +E +R+RE EER ++ A E A+ Sbjct: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106 >gi|45439327 periplakin [Homo sapiens] Length = 1756 Score = 413 bits (1062), Expect = e-114 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%) Query: 531 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 590 L ++ +LQ A E+ + +A +QSD+ L G+ P+ + + ++ ++ +L Sbjct: 27 LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86 Query: 591 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 650 D K +HPQG+ + + +L ER+ +R ++ Q+ ++ ++ V Sbjct: 87 ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133 Query: 651 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 710 P++ + L VEE +++ +G DLP V+ Q+ H H ++ + Sbjct: 134 -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183 Query: 711 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 770 + E L +Y KLL +S+AR + L SL ++ T EL WL+ Sbjct: 184 KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230 Query: 771 EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 829 ++ + + +DWSDRN + +++ Y + R LE KE++I +L + GD+LL +HP R + Sbjct: 231 QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290 Query: 830 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 889 +E+ A+ W L L C E+HLK Y QF DV++A+ L+K+ L +KY D Sbjct: 291 IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350 Query: 890 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 949 ++E LL++ D+++ L++Y+ + GL KR + VV LK R P++ +P+ A+ Sbjct: 351 FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407 Query: 950 CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 1009 CD++ + + +G L S W+++ S+G++ P+VCF++PP Sbjct: 408 CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454 Query: 1010 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 1069 D ++L SL + +R + + RTL +QR + E Sbjct: 455 ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496 Query: 1070 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1129 D+ D G +QLL L++ A + R ++ I+ + Sbjct: 497 -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528 Query: 1130 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1188 LR PL++ A ++ A+R + + E+ + R +AE E + Sbjct: 529 --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574 Query: 1189 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1248 S P LR+ +E T K E + L + EK+ + + + Q + E+L HE Sbjct: 575 QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634 Query: 1249 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308 L + VP + L++ L + + +AQ+ + L+ A++ L R E Sbjct: 635 LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694 Query: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1368 ++ER V +L +R+ + Q + R + L+ ++ D + +L + Sbjct: 695 PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754 Query: 1369 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1427 Q DS + E +L+ ++ LL+EI ++V++ ++QY A+KDYEL+ + Sbjct: 755 Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809 Query: 1428 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1483 + L+ + +K+ ++QS + V +E L ++E+ + Q ++ + L + + Sbjct: 810 SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869 Query: 1484 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1534 + + +R R + VE A + +++L E + + Q E E K Q+ + Sbjct: 870 QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928 Query: 1535 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1575 QE VVR+E + Q + + +QEEL+ L+ Q E + + Sbjct: 929 QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988 Query: 1576 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1624 E + LRIE +E+ +R +LEA RQ+G E E+ L+ R E++ A Sbjct: 989 GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048 Query: 1625 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1679 Q++ ++E +L+ Q E+ Q Q + +L + + E ++K L+ LE+ R Sbjct: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105 Query: 1680 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1737 AE +VE+ + + R E E RAS EKT L + +L+EE+ Sbjct: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165 Query: 1738 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1784 V ++RE E + E ER AE +L +Q + EALR R Sbjct: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224 Query: 1785 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1843 EV + K + + + + + E+ + R + + + + +L +L+K+ Q + T Sbjct: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284 Query: 1844 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1897 Q E QE+++ + + + E+ + +L EE+ ++ E A+Q+ Q E Sbjct: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344 Query: 1898 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1954 R + V+ R EEE +E S + ++ E + +L E RL+ E +RQ Sbjct: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404 Query: 1955 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 2006 +L E AR+ AE E + L ++LAA+ EA T + + +++ + R L RL Sbjct: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464 Query: 2007 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 2066 +E RR+L E + + +LA L KA E++ + L E ++ E+EI Sbjct: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518 Query: 2067 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 2124 LK+S E+ + K EL++E+ R+ + + SK EL+ R+ + ER+ + E Sbjct: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578 Query: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2183 R L +E A L + + RL E + ++L ++ Sbjct: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635 Query: 2184 LQAEEKAHAFAVQQKEQELQQTL 2206 LQ + A +Q+E L++++ Sbjct: 1636 LQKRLGSVAVKREQRENHLRRSI 1658 Score = 187 bits (476), Expect = 2e-46 Identities = 338/1485 (22%), Positives = 609/1485 (41%), Gaps = 254/1485 (17%) Query: 1505 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1564 AL L + + +A + LQQR EV++ E + Q R + L ++ Sbjct: 459 ALALADSLGSQYRSVRQKAAGSKRTLQQRY--EVLKTENPGDASDLQGRQLLAGLDKV-- 514 Query: 1565 SSEAEIQAKA---------RQAEAAERSRLRIEEEIRVVR--LQLEATERQRGGAEGELQ 1613 +S+ + Q KA Q A + S R ++ + L++E E+ R AEGE Sbjct: 515 ASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEP-EKTRSTAEGE-- 571 Query: 1614 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673 A Q LR +V+D + RK + ++L + + + A +++LQ Sbjct: 572 --------AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQ 622 Query: 1674 ALEELRLQAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1732 EL E L Q + V + +V + + ELQ++++ E L+ + Sbjct: 623 QSWEL---LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAA 679 Query: 1733 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1792 Q ++ +E +Q+AE + + LR Q E AQ Sbjct: 680 KQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSL 725 Query: 1793 SLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1849 A+A E + + + E Q E +L+ Q+ L + A + E Sbjct: 726 QSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----E 781 Query: 1850 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1909 QE+ ++ A ++Q +Q K ELEAE + ++E +S Sbjct: 782 QEVQKICANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHV 822 Query: 1910 RAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968 +S + K K+ A A +F E+ A RL+ L RQ E + + + Sbjct: 823 SKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQR 882 Query: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 2028 R + + EA +++ KE + E ER R+L + + + Q + Sbjct: 883 NR----PDSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQES 931 Query: 2029 EERLAQLRKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKA 2079 R L+K D LE ++ TL + + ++EE+ AL+ E G+ Sbjct: 932 VVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991 Query: 2080 ELELELGRI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 2136 + E+ RI R+ A++ L+ +E ELEA R+++ A E AE Sbjct: 992 YVVKEVLRIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVL 1032 Query: 2137 AARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2195 +QR AAL EE R + KV E ++ + + + + Q QE Q++ Q EK Sbjct: 1033 LLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK------ 1086 Query: 2196 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAER 2253 +E+EL LQ + L++ R AE E + E ERE + RQ E EA + Sbjct: 1087 --QEEELS-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAK 1143 Query: 2254 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------Q 2298 + S E+ + + A E+ K QE R +A++E A LR + + Sbjct: 1144 ARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYR 1203 Query: 2299 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2358 A+ ++ ++ E R+ QVE + T + +TD + +++ELQRL+ E + R Sbjct: 1204 GAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTR 1260 Query: 2359 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2418 + + E++ ++ +++ L K +++ K+ Q LQ + + Q EE A Sbjct: 1261 LIERCDLEIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVA 1309 Query: 2419 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2478 L E Q + DL ++RA E+ + K E EL + ++ + Q+ Sbjct: 1310 SLRAKLSE----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQ 1353 Query: 2479 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2538 + R +E+ L E F +++ E ++ ++ AE RL+ R E+ R E Sbjct: 1354 EVVRYEEEPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELER 1408 Query: 2539 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2598 + Q R++++ + +RL++ +A LE+E+ + Sbjct: 1409 ERQA--------------------------------RREAEREVQRLQQRLAALEQEEAE 1436 Query: 2599 LQQEAKLLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2656 +++ Q + ++ Q ++ LL+ LQ + LL+ E +E + KL L Sbjct: 1437 AREKVTHTQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAAL 1490 Query: 2657 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-- 2714 + EV + L E Q ++ EQE QRL +S+EE R + E + V R + L +LE Sbjct: 1491 EKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFH 1550 Query: 2715 -QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2773 + ++ + L EEN +L+ + Q L+ + R + +AAT+T RD + Sbjct: 1551 NSKSSKELDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMT 1600 Query: 2774 AAEAEPEHS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ 2830 A++ H L R++ +RL + L +ELQ+ G V +RE ++L Sbjct: 1601 VADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL- 1654 Query: 2831 GRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLL 2877 R SI ++ T +LS A R L + L +Q S + Sbjct: 1655 -RRSIV-VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIH 1711 Query: 2878 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2922 D ++ ++ EA++ G + P + + ++ + ++ +GQ+ Sbjct: 1712 DRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756 Score = 85.1 bits (209), Expect = 1e-15 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%) Query: 4266 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4325 K + + +R +V++ P+TG+E+S EA+R GLID +++L QEC+WEEI++ +G Sbjct: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705 Query: 4326 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4375 S+I DR+SG+++ I++A+ + + D+Y +SI E A ++SG Sbjct: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754 >gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo sapiens] Length = 2364 Score = 400 bits (1029), Expect = e-110 Identities = 574/2472 (23%), Positives = 1018/2472 (41%), Gaps = 319/2472 (12%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233 DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+ KGRMR Sbjct: 50 DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 109 Query: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292 H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V + Sbjct: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 169 Query: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351 E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K+ + Sbjct: 170 KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 229 Query: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410 NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ + +G R Sbjct: 230 AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 289 Query: 411 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463 A E + ++Y L LL+W+ R+F +S ++ F ++ Sbjct: 290 IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 349 Query: 464 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520 +E P K +K + + +++ ++A KV G D+ K W +L A ERE Sbjct: 350 VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 409 Query: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577 LR+E R E L+++ + +A + E L++ L+ D L A ++ +E Sbjct: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 469 Query: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 634 D+ + ++ + + L+ + +++ R V RL E L+ + RL+ + Sbjct: 470 DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 529 Query: 635 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 694 LQ + + + Y+ D W++E + V ++G L VE L Sbjct: 530 ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 569 Query: 695 HRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 744 H + + + A ++ +D P RD + ++ Y +L Sbjct: 570 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 629 Query: 745 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804 +ARL L F +E W+ EKE+ D+ T++ + A E+ Sbjct: 630 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 689 Query: 805 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864 + ++ G+ ++ E+H + ++ QW+ + QL + L+E + QF Sbjct: 690 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 749 Query: 865 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 924 +D + + + + L+ S D + L++ +D E++ Y+ L L ++ Sbjct: 750 QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 806 Query: 925 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 967 A A+ Q P +RGRL + YK+V E+T + D C+L Sbjct: 807 ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 863 Query: 968 ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEAV------- 1006 P + +V+ E + + V NQ A++ + Sbjct: 864 WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 923 Query: 1007 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 1058 ++AQ L T W Q VD K S L+ Q+ + +SW + ++ + Sbjct: 924 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 983 Query: 1059 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1101 + L ++E ++++ P+ S Sbjct: 984 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1043 Query: 1102 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1158 ++++ L++ E E S+ Q+ + +L D + L +T + + Sbjct: 1044 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1092 Query: 1159 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1209 + E +K + E + + + +K+ + E T LR L+ L G Sbjct: 1093 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1152 Query: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269 +L ++ L + +R T+ AE L E L + +P T LE +A++ Sbjct: 1153 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1208 Query: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329 KK E T DA +++ E G RL + ++ +R +E+V + +R + Sbjct: 1209 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1261 Query: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1389 L+ R L+ + + L W+ + + Q M +++ + + + Q Sbjct: 1262 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNLHSKWLKHQ 1317 Query: 1390 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKKPKVQSGSE 1447 A + E+ + K++++ I+ +QL++ K + E V K+ E Sbjct: 1318 AFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLE 1366 Query: 1448 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1507 S Q R + L +Q + + L +E ++ Q + + L V L+ Sbjct: 1367 STTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDLTSVNILLK 1420 Query: 1508 KQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQEELQQLRQS 1565 KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q + +L + Sbjct: 1421 KQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEP 1473 Query: 1566 SEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALRARAEEAE 1623 E + +R +E+EI V R+ L AT G LQ ++ ++ + Sbjct: 1474 LNERKHNLLASKEIHQFNR-DVEDEILWVGERMPL-ATSTDHG---HNLQTVQLLIKKNQ 1528 Query: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683 +++ Q R + D +R + + +S AEA R++ L+ L L + E Sbjct: 1529 TLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLWGLLI--E 1579 Query: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743 E E+R R+ E E R Q + A+ AEA + + E E ++E AV+ L Sbjct: 1580 ETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDEQSAVSML 1631 Query: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803 ++ + E+ +E + AE V Q ++A Sbjct: 1632 KK---------------HQILEQAVEDY-------------AETVHQLSKTSRALVADSH 1663 Query: 1804 EEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAEQELIRLR 1856 E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE+E++ Sbjct: 1664 PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGS 1723 Query: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916 E Q + +L+E R+ Q+R + LA E++ + + A Sbjct: 1724 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDA----- 1773 Query: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976 +T + K L EL + ++ A + E + A+E R + + + L E+L Sbjct: 1774 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKHKKLPEEL 1832 Query: 1977 A----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032 + R+ T E + +A ++R+L ED A RL+ A KAD Sbjct: 1833 GRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDKAD----- 1880 Query: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092 ++K + LE K L+ D RR + F +E + +I A Sbjct: 1881 -DIQKRENEVLEAWKSLL-DACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI--EA 1936 Query: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRKAALEEVER 2150 ++ R EL + + AE + R ++ KSL AR+ A+ E E+ Sbjct: 1937 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHYASEEIKEK 1991 Query: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210 L E+ + + ++ E + L+L E Q A A A+ + Q+ + + Q Sbjct: 1992 LLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLSSREIGQSV 2049 Query: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ--SAEEQAQA 2264 +++L EA ++A +E ER E + RRQ EE ER ++ S E + Sbjct: 2050 DEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKV 2109 Query: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2324 +A++ + + EQ + AEQ + R + D +++ Sbjct: 2110 SEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT----------------SEMVNG 2153 Query: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI 2384 T R +E+ + + + A AA ++ +E + QME K Sbjct: 2154 ATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQMEGFLNRKHEW 2210 Query: 2385 EAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2444 EA N+ R N + + + A+ A A+ + +E ++ + A+ Sbjct: 2211 EAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYHSEVPVSLKEAV 2261 Query: 2445 AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRT 2504 E L K + RL E L Q K+ +E +Q ++ E + Q T Sbjct: 2262 CEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSDKHEVSASTQST 2320 Query: 2505 LEAERQRQLEMS 2516 + R + L S Sbjct: 2321 PASSRAQTLPTS 2332 Score = 104 bits (259), Expect = 2e-21 Identities = 340/1836 (18%), Positives = 710/1836 (38%), Gaps = 258/1836 (14%) Query: 1117 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1176 S QR +S+ + L A E T + D E Q + + + E E Sbjct: 439 SENQRLVSQ-DNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR-ELEAENY-HD 495 Query: 1177 VARLSAEAEKVLALPE---PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI- 1232 + R++A + V+ L E A R E+ L L K+ Q +++++K + L Sbjct: 496 IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQD 555 Query: 1233 --RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF-DALRDE 1289 + G E++L+ H L EA + + AS +K E +P +RD Sbjct: 556 YGKHLLGVEDLLQKHT--LVEAD-IGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR 612 Query: 1290 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1349 + + + L Q ER +E R L ++ +A+ + RE E++ Sbjct: 613 VAHMEFCYQELCQLAAERRARLEESRR-----LWKFFWEMAEEEGWIREKEKI------- 660 Query: 1350 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409 S+D G L R L+ +A +++ E+ + GE + + F Sbjct: 661 -LSSDDYGKDLTSVMRL--------LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG 711 Query: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469 + I++ + + A LE +++ KK ++ Q D ++ Sbjct: 712 SE---KIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD------DIDAWMLD 762 Query: 1470 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1529 +K +S + +E + Q ++ + +AE A A A Q E+ + Sbjct: 763 ILKIVSSSDVGHDE---YSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPD 819 Query: 1530 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1589 ++ R+ R +E A + +K+++Q+ L + SEA+ + + ++I E Sbjct: 820 VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 879 Query: 1590 ---EIRVVRLQLEATERQRGGAEGELQALRARAEE-------AEAQKRQAQEEAERLRRQ 1639 ++ V++ + E+ E + + + A + +E + + Q++ Q Sbjct: 880 KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 939 Query: 1640 VQDESQRKRQAEVELASRVKAEAEA------AREKQRALQALEELRLQAEEA---ERRLR 1690 ++ RK+ A + S E REK + +++ ++L +R+L Sbjct: 940 FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 999 Query: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREE 1746 E + ++ L Q+ AE +L+S+ A+ + A++ + EE + RE Sbjct: 1000 GMERDLVA-IEAKLSDLQKEAE-KLESEHPDQAQAILSRLAEIS-DVWEEMKTTLKNREA 1056 Query: 1747 AERRAQQQAEAERAREEAERELERWQLKA---------NEALRLRLQAEEVAQQKSLAQA 1797 + A + + R ++ + L R Q EA +L Q E + + + Sbjct: 1057 SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEE 1116 Query: 1798 EAEKQKEEAEREARRRGKAEEQAVRQR---------ELAEQELEKQRQLAEGTAQQRLAA 1848 + +K ++ E + + A+ +RQR EL + +Q L++ A Q+ Sbjct: 1117 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1176 Query: 1849 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908 + + +AE Q+ L E+ A AA +K+++ + ++ ++ + Sbjct: 1177 DTK----QAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETG 1232 Query: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968 R + S++ ++++++ R R+ E A+ L ++ + ++ ++ Sbjct: 1233 RRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN 1292 Query: 1969 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026 E++L + + EA L ++ A + A N+ E E Q L + + +A Sbjct: 1293 EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ---LISEKPETEA 1349 Query: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086 ++E+L L K + + L Q + + L E A+L+ L Sbjct: 1350 VVKEKLTGLHK------------MWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH 1397 Query: 2087 RIRSN--AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2144 + S ++D + + +Q+ L + E R++E EE L ++ +A Q + Sbjct: 1398 GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE-----LQSQAQALSQEGKS 1452 Query: 2145 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------------- 2190 +EV+ + V+ E L ++E Q E++ Sbjct: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512 Query: 2191 HAFAVQ------QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244 H +Q +K Q LQ+ +Q Q +D + E ++ ++ +A R+ Sbjct: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI---FERSQNIVTDSSSLSAEAIRQRLAD 1569 Query: 2245 RRQ-----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299 +Q +EE E+ + EE +A+ AAE +EQE ++ + + +Q+ Sbjct: 1570 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA---KDEQS 1626 Query: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATE 2355 A + ++KH+ EQ + A+ +L+ L H ++ + ++ +L A + Sbjct: 1627 AVSMLKKHQ-ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1685 Query: 2356 AARQRSQVEEE---LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412 A +R +E LF + ++++L + A E + L LQE + ++ Sbjct: 1686 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE---RFRE 1742 Query: 2413 VAEEAARLSVAAQEAARLRQLAEE----------DLAQQRALAEKMLKEKMQAVQEATRL 2462 A + ++ + + LA+E +A+ + + + ++ + T++ Sbjct: 1743 FARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI 1800 Query: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA------EETQGFQRTLEAERQ------ 2510 A + L + A+E R+Q+ +++ ++L E Q T E + Q Sbjct: 1801 LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV 1860 Query: 2511 RQLEMSA----------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR---- 2556 RQL+ A +A+ ++ R E+ A + + R + + G+K Sbjct: 1861 RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV 1920 Query: 2557 -----------TELATQEKVTLVQTLEI-----QRQQSDHDA------------------ 2582 ++ QEK V ++E+ Q +++ DA Sbjct: 1921 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980 Query: 2583 -----ERLREAIAEL-EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633 E ++E + +L E+ KE K + + L+L E Q + + + Q+ +L Sbjct: 1981 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040 Query: 2634 S---------EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684 S E + L++R E+ A ++ F + + L + R+QQ+ E+ER+R Sbjct: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKR 2098 Query: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHR 2743 S E + + EAE Q++ + ++ Q L AE+ + R+ E + E + Sbjct: 2099 RPPSPEPSTKVSEEAE-----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNG 2153 Query: 2744 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2779 A + +S + + + + AL +A P Sbjct: 2154 ATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLP 2189 Score = 103 bits (257), Expect = 4e-21 Identities = 323/1633 (19%), Positives = 650/1633 (39%), Gaps = 190/1633 (11%) Query: 1160 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1219 +++ + + E+ G + E E ++A E + +R + + + LSA Sbjct: 677 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734 Query: 1220 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1278 I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE Sbjct: 735 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793 Query: 1279 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1335 +PT D L ++ L Q H E DV R R++ + ER++ V T +R Sbjct: 794 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841 Query: 1336 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1394 ++ L+ + + E AD W+ + + +Q L D + ++ + ++L E Sbjct: 842 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897 Query: 1395 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1454 + +V + A+Q +++ E ++ + +L S ++ + + + + Sbjct: 898 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955 Query: 1455 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1505 ++ ++ E S +I E + +E + L A Q++ ER L +EA Sbjct: 956 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011 Query: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1562 L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L Sbjct: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068 Query: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622 R + + Q A E + Q E + + E + Q +R E Sbjct: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128 Query: 1623 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1676 + AQ R R Q D E + + L S+ A + R+ ++A L + Sbjct: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188 Query: 1677 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1731 E L E L AE +++ ++ + A +++ R ++ +R Sbjct: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248 Query: 1732 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1779 S+ + H + E R + + ++ ++ + EL W + +EA Sbjct: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307 Query: 1780 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836 L ++ + Q +A+ + K+ K E E K E +AV + +L L K + Sbjct: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363 Query: 1837 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1888 + E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q Sbjct: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423 Query: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948 LE ++ + E+E L + +E +ST E +RL + +F EL E Sbjct: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475 Query: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1999 +R+ L A+++ + R + +++ +GE L T + + +K+ + Sbjct: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530 Query: 2000 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 2055 + ++ + D+ F+R + + + ++ I +RLA L++ L+E+T + Sbjct: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583 Query: 2056 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 2112 + R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+ Sbjct: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638 Query: 2113 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2170 A E+ + ++L A+ +R + + +V++L A +++ R E Sbjct: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698 Query: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2229 R QL +E E+ + Q+ + ++ + R + + Sbjct: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758 Query: 2230 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286 A+E +AA + E R Q AA+ +L K Sbjct: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814 Query: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346 K+ +KHKK E+ R + VE TL+ +H L ++ Sbjct: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVE----TLQRMHTTFEHDIQALGTQV 1860 Query: 2347 QRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEA-ENRALILRDKDNTQRFLQ 2404 ++L+ +A A Q + ++ ++ + E L K+ ++A E+R + L D + RF Sbjct: 1861 RQLQEDA--ARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1918 Query: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--TRL 2462 + M + E+ R + AQE + R ++ +L + +K ++ A ++ T + Sbjct: 1919 MVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTTCI 1971 Query: 2463 KAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519 + LL ++ E +E+ +L E +++M + + + + LE + + AEA Sbjct: 1972 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2031 Query: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQ 2576 L SR ++ ++ ++ K+ E EK T + E++T ++ LE++RQ Sbjct: 2032 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVRRQ 2090 Query: 2577 QSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2631 Q + + +R E ++ E E QQ +K Q+ + Q + ET Sbjct: 2091 QEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD---- 2146 Query: 2632 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRLVA 2687 SE + +R +E + + D AK AQ R Q+ A Sbjct: 2147 -TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS-------A 2198 Query: 2688 SMEEARRRQHEAE 2700 ME R+HE E Sbjct: 2199 QMEGFLNRKHEWE 2211 Score = 100 bits (249), Expect = 3e-20 Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%) Query: 1303 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1362 R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL + Sbjct: 384 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440 Query: 1363 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1412 +R Q D AV ++ +A+ +I + E+V+ A++ Sbjct: 441 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498 Query: 1413 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1470 I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y Sbjct: 499 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556 Query: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530 K + + + ++ L E + ER+ V A+ +K E + Q R+ Sbjct: 557 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615 Query: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1588 + +E+ + ++R+ EE ++L + AE + R+ E S + Sbjct: 616 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668 Query: 1589 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646 + V+RL + A E + G G + E+ A++ +E++R ++ R Sbjct: 669 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723 Query: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706 ++ A +E S ++ +++ L + + A++ + + ++ + V + Sbjct: 724 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773 Query: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766 + L K AE+ A +L H E+A Q+ AE+ R Sbjct: 774 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826 Query: 1767 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1820 ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+ Sbjct: 827 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885 Query: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1875 V Q E E Q + ++A + +E E QQ +L EL Sbjct: 886 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945 Query: 1876 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931 +++A +A + + LE K +R + +V+ +++ + + + + K G Sbjct: 946 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000 Query: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1991 R+L A+L L +EA E + + + + +LA I + E + Sbjct: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049 Query: 1992 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 2045 LK +EA E +L++ D + FQ Q A D+ L + K ++ Sbjct: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109 Query: 2046 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 2092 + E+ ++ R Q + + + L+ + G EL ++ R N Sbjct: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168 Query: 2093 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2148 + LR +QAE Q + A E + +L E A ++++ + + Sbjct: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219 Query: 2149 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2204 E++ A VE RRL S R + + + E A ++ K+ ++LQ+ Sbjct: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279 Query: 2205 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260 LQ Q + +++ + + A ++ + A+ E +++++ + Sbjct: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339 Query: 2261 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309 + + +A E L + +A R A +A L + AD + H Sbjct: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397 Query: 2310 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366 ++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E Sbjct: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455 Query: 2367 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2419 + S R VQ + + L+ E ++ L ++ R +++E E+M + + Sbjct: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515 Query: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479 Q + Q ++++ + + + + V +++ L AEA Sbjct: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562 Query: 2480 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2535 R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+ Sbjct: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622 Query: 2536 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2586 E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L Sbjct: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680 Query: 2587 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642 + +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ Sbjct: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737 Query: 2643 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2682 ERF I QE+ DE +A+ + E ++ R Sbjct: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797 Query: 2683 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2739 +++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L Sbjct: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857 Query: 2740 EQHR 2743 Q R Sbjct: 1858 TQVR 1861 >gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo sapiens] Length = 2155 Score = 397 bits (1019), Expect = e-109 Identities = 535/2251 (23%), Positives = 945/2251 (41%), Gaps = 290/2251 (12%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233 DER+ VQKKTFTKWVN HL + I+DLY DLRDG LI LLEVLSG+ LP+ KGRMR Sbjct: 37 DEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLPKPTKGRMR 96 Query: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292 H L+NV AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI DI V + Sbjct: 97 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETEDN 156 Query: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351 E +AK+ LLLW Q GY + NFT+SWRDG FNA+IH+H+P LID +K+ + Sbjct: 157 KEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSN 216 Query: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410 NL AF++AE+ LG+T+LLDPED+ V PDEKSIITYV + Y ++ + +G R Sbjct: 217 AHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMKALAVEGKR 276 Query: 411 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463 A E + ++Y L LL+W+ R+F +S ++ F ++ Sbjct: 277 IGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQLQAFNTYRT 336 Query: 464 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520 +E P K +K + + +++ ++A KV G D+ K W +L A ERE Sbjct: 337 VEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEKAEHERELA 396 Query: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577 LR+E R E L+++ + +A + E L++ L+ D L A ++ +E Sbjct: 397 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAATKKHEAIET 456 Query: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYNLRLKAGVA 634 D+ + ++ + + L+ + +++ R V RL E L+ + RL+ + Sbjct: 457 DIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARRQRLEMNLG 516 Query: 635 APATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGS 694 LQ + + + Y+ D W++E + V ++G L VE L Sbjct: 517 ----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLLGVEDLLQK 556 Query: 695 HRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLN---S 744 H + + + A ++ +D P RD + ++ Y +L Sbjct: 557 HTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQELCQLAAE 616 Query: 745 SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804 +ARL L F +E W+ EKE+ D+ T++ + A E+ Sbjct: 617 RRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHRAFEDEMSG 676 Query: 805 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864 + ++ G+ ++ E+H + ++ QW+ + QL + L+E + QF Sbjct: 677 RSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQF 736 Query: 865 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 924 +D + + + + L+ S D + L++ +D E++ Y+ L L ++ Sbjct: 737 QADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRPTLDTLHEQ 793 Query: 925 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------VHKGDECQL 967 A A+ Q P +RGRL + YK+V E+T + D C+L Sbjct: 794 ASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMFSEADACEL 850 Query: 968 ------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEAV------- 1006 P + +V+ E + + V NQ A++ + Sbjct: 851 WIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSE 910 Query: 1007 TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATFRTLKPEE- 1058 ++AQ L T W Q VD K S L+ Q+ + +SW + ++ + Sbjct: 911 KEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQD 970 Query: 1059 -----------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1101 + L ++E ++++ P+ S Sbjct: 971 LGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDV 1030 Query: 1102 YQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQ 1158 ++++ L++ E E S+ Q+ + +L D + L +T + + Sbjct: 1031 WEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-----------SEDMPN 1079 Query: 1159 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSELE-LTLG-- 1209 + E +K + E + + + +K+ + E T LR L+ L G Sbjct: 1080 TLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWN 1139 Query: 1210 KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASL 1269 +L ++ L + +R T+ AE L E L + +P T LE +A++ Sbjct: 1140 ELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT---LEGAEAAI 1195 Query: 1270 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVL 1329 KK E T DA +++ E G RL + ++ +R +E+V + +R + Sbjct: 1196 KK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSIDDRHRKNR 1248 Query: 1330 AQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQ 1389 L+ R L+ + + L W+ + + Q M +++ + + + Q Sbjct: 1249 ETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNLHSKWLKHQ 1304 Query: 1390 ALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKKPKVQSGSE 1447 A + E+ + K++++ I+ +QL++ K + E V K+ E Sbjct: 1305 AFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLE 1353 Query: 1448 SVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALE 1507 S Q R + L +Q + + L +E ++ Q + + L V L+ Sbjct: 1354 STTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDLTSVNILLK 1407 Query: 1508 KQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQEELQQLRQS 1565 KQ+ L + Q E KE+++ + Q + + +E + D KR ++Q + +L + Sbjct: 1408 KQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQTKFMELLEP 1460 Query: 1566 SEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQALRARAEEAE 1623 E + +R +E+EI V R+ L AT G LQ ++ ++ + Sbjct: 1461 LNERKHNLLASKEIHQFNR-DVEDEILWVGERMPL-ATSTDHG---HNLQTVQLLIKKNQ 1515 Query: 1624 AQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAE 1683 +++ Q R + D +R + + +S AEA R++ L+ L L + E Sbjct: 1516 TLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQLWGLLI--E 1566 Query: 1684 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1743 E E+R R+ E E R Q + A+ AEA + + E E ++E AV+ L Sbjct: 1567 ETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKDEQSAVSML 1618 Query: 1744 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1803 ++ + E+ +E + AE V Q ++A Sbjct: 1619 KK---------------HQILEQAVEDY-------------AETVHQLSKTSRALVADSH 1650 Query: 1804 EEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAAEQELIRLR 1856 E+ER + R+ K ++ ++LAE+ +L+++ +L + + ++ AE+E++ Sbjct: 1651 PESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGS 1710 Query: 1857 AETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916 E Q + +L+E R+ Q+R + LA E++ + + A Sbjct: 1711 HELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGHSDA----- 1760 Query: 1917 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKL 1976 +T + K L EL + ++ A + E + A+E R + + + L E+L Sbjct: 1761 ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DKHKKLPEEL 1819 Query: 1977 A----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERL 2032 + R+ T E + +A ++R+L ED A RL+ A KAD Sbjct: 1820 GRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGDKAD----- 1867 Query: 2033 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 2092 ++K + LE K L+ D RR + F +E + +I A Sbjct: 1868 -DIQKRENEVLEAWKSLL-DACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQI--EA 1923 Query: 2093 EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRKAALEEVER 2150 ++ R EL + + AE + R ++ KSL AR+ A+ E E+ Sbjct: 1924 QEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHYASEEIKEK 1978 Query: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210 L E+ + + ++ E + L+L E Q A A A+ + Q+ + + Q Sbjct: 1979 LLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLSSREIGQSV 2036 Query: 2211 SVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ--SAEEQAQA 2264 +++L EA ++A +E ER E + RRQ EE ER ++ S E + Sbjct: 2037 DEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKV 2096 Query: 2265 RAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2295 +A++ + + EQ + AEQ + R Sbjct: 2097 SEEAESQQQWDTSKGEQVSQNGLPAEQGSPR 2127 Score = 103 bits (256), Expect = 5e-21 Identities = 300/1528 (19%), Positives = 616/1528 (40%), Gaps = 172/1528 (11%) Query: 1160 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1219 +++ + + E+ G + E E ++A E + +R + + + LSA Sbjct: 664 LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 721 Query: 1220 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1278 I ++L+ SL+ + A+++ + LK + E +T++ +KK + AE Sbjct: 722 IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 780 Query: 1279 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1335 +PT D L ++ L Q H E DV R R++ + ER++ V T +R Sbjct: 781 ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 828 Query: 1336 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1394 ++ L+ + + E AD W+ + + +Q L D + ++ + ++L E Sbjct: 829 KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 884 Query: 1395 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1454 + +V + A+Q +++ E ++ + +L S ++ + + + + Sbjct: 885 MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 942 Query: 1455 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1505 ++ ++ E S +I E + +E + L A Q++ ER L +EA Sbjct: 943 SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 998 Query: 1506 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1562 L ++ AE + +++ +A+ + R+ E EE + ++ S+ E +LQQ L Sbjct: 999 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1055 Query: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622 R + + Q A E + Q E + + E + Q +R E Sbjct: 1056 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1115 Query: 1623 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1676 + AQ R R Q D E + + L S+ A + R+ ++A L + Sbjct: 1116 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1175 Query: 1677 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1731 E L E L AE +++ ++ + A +++ R ++ +R Sbjct: 1176 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1235 Query: 1732 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1779 S+ + H + E R + + ++ ++ + EL W + +EA Sbjct: 1236 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1294 Query: 1780 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1836 L ++ + Q +A+ + K+ K E E K E +AV + +L L K + Sbjct: 1295 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1350 Query: 1837 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1888 + E T Q QRL A + EL A+ ++ + Q+ ++ + +K+Q Sbjct: 1351 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1410 Query: 1889 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1948 LE ++ + E+E L + +E +ST E +RL + +F EL E Sbjct: 1411 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1462 Query: 1949 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1999 +R+ L A+++ + R + +++ +GE L T + + +K+ + Sbjct: 1463 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1517 Query: 2000 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 2055 + ++ + D+ F+R + + + ++ I +RLA L++ L+E+T + Sbjct: 1518 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1570 Query: 2056 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 2112 + R++EE A + F+ A A E EL + A+D EQ+ + ++ Q+ Sbjct: 1571 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1625 Query: 2113 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2170 A E+ + ++L A+ +R + + +V++L A +++ R E Sbjct: 1626 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1685 Query: 2171 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2229 R QL +E E+ + Q+ + ++ + R + + Sbjct: 1686 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1745 Query: 2230 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2286 A+E +AA + E R Q AA+ +L K Sbjct: 1746 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1801 Query: 2287 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2346 K+ +KHKK E+ R + VE TL+ +H L ++ Sbjct: 1802 ----------KEIFGRIQDKHKKLPEELGRDQNTVE----TLQRMHTTFEHDIQALGTQV 1847 Query: 2347 QRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEA-ENRALILRDKDNTQRFLQ 2404 ++L+ +A A Q + ++ ++ + E L K+ ++A E+R + L D + RF Sbjct: 1848 RQLQEDA--ARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1905 Query: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--TRL 2462 + M + E+ R + AQE + R ++ +L + +K ++ A ++ T + Sbjct: 1906 MVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTTCI 1958 Query: 2463 KAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2519 + LL ++ E +E+ +L E +++M + + + + LE + + AEA Sbjct: 1959 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2018 Query: 2520 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQ 2576 L SR ++ ++ ++ K+ E EK T + E++T ++ LE++RQ Sbjct: 2019 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVRRQ 2077 Query: 2577 QSDHDAER---LREAIAELEREKEKLQQ 2601 Q + + +R E ++ E E QQ Sbjct: 2078 QEEEERKRRPPSPEPSTKVSEEAESQQQ 2105 Score = 101 bits (251), Expect = 2e-20 Identities = 329/1778 (18%), Positives = 687/1778 (38%), Gaps = 252/1778 (14%) Query: 1117 SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1176 S QR +S+ + L A E T + D E Q + + + E E Sbjct: 426 SENQRLVSQ-DNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR-ELEAENY-HD 482 Query: 1177 VARLSAEAEKVLALPE---PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI- 1232 + R++A + V+ L E A R E+ L L K+ Q +++++K + L Sbjct: 483 IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQD 542 Query: 1233 --RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF-DALRDE 1289 + G E++L+ H L EA + + AS +K E +P +RD Sbjct: 543 YGKHLLGVEDLLQKHT--LVEAD-IGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR 599 Query: 1290 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1349 + + + L Q ER +E R L ++ +A+ + RE E++ Sbjct: 600 VAHMEFCYQELCQLAAERRARLEESRR-----LWKFFWEMAEEEGWIREKEKI------- 647 Query: 1350 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1409 S+D G L R L+ +A +++ E+ + GE + + F Sbjct: 648 -LSSDDYGKDLTSVMRL--------LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG 698 Query: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469 + I++ + + A LE +++ KK ++ Q D ++ Sbjct: 699 SE---KIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD------DIDAWMLD 749 Query: 1470 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1529 +K +S + +E + Q ++ + +AE A A A Q E+ + Sbjct: 750 ILKIVSSSDVGHDE---YSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPD 806 Query: 1530 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1589 ++ R+ R +E A + +K+++Q+ L + SEA+ + + ++I E Sbjct: 807 VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 866 Query: 1590 ---EIRVVRLQLEATERQRGGAEGELQALRARAEE-------AEAQKRQAQEEAERLRRQ 1639 ++ V++ + E+ E + + + A + +E + + Q++ Q Sbjct: 867 KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 926 Query: 1640 VQDESQRKRQAEVELASRVKAEAEA------AREKQRALQALEELRLQAEEA---ERRLR 1690 ++ RK+ A + S E REK + +++ ++L +R+L Sbjct: 927 FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 986 Query: 1691 QAEVERARQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREE 1746 E + ++ L Q+ AE +L+S+ A+ + A++ + EE + RE Sbjct: 987 GMERDLVA-IEAKLSDLQKEAE-KLESEHPDQAQAILSRLAEIS-DVWEEMKTTLKNREA 1043 Query: 1747 AERRAQQQAEAERAREEAERELERWQLKA---------NEALRLRLQAEEVAQQKSLAQA 1797 + A + + R ++ + L R Q EA +L Q E + + + Sbjct: 1044 SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEE 1103 Query: 1798 EAEKQKEEAEREARRRGKAEEQAVRQR---------ELAEQELEKQRQLAEGTAQQRLAA 1848 + +K ++ E + + A+ +RQR EL + +Q L++ A Q+ Sbjct: 1104 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1163 Query: 1849 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908 + + +AE Q+ L E+ A AA +K+++ + ++ ++ + Sbjct: 1164 DTK----QAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETG 1219 Query: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968 R + S++ ++++++ R R+ E A+ L ++ + ++ ++ Sbjct: 1220 RRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN 1279 Query: 1969 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 2026 E++L + + EA L ++ A + A N+ E E Q L + + +A Sbjct: 1280 EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ---LISEKPETEA 1336 Query: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086 ++E+L L K + + L Q + + L E A+L+ L Sbjct: 1337 VVKEKLTGLHK------------MWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH 1384 Query: 2087 RIRSN--AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 2144 + S ++D + + +Q+ L + E R++E EE L ++ +A Q + Sbjct: 1385 GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE-----LQSQAQALSQEGKS 1439 Query: 2145 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------------- 2190 +EV+ + V+ E L ++E Q E++ Sbjct: 1440 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1499 Query: 2191 HAFAVQ------QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2244 H +Q +K Q LQ+ +Q Q +D + E ++ ++ +A R+ Sbjct: 1500 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI---FERSQNIVTDSSSLSAEAIRQRLAD 1556 Query: 2245 RRQ-----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2299 +Q +EE E+ + EE +A+ AAE +EQE ++ + + +Q+ Sbjct: 1557 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA---KDEQS 1613 Query: 2300 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATE 2355 A + ++KH+ EQ + A+ +L+ L H ++ + ++ +L A + Sbjct: 1614 AVSMLKKHQ-ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1672 Query: 2356 AARQRSQVEEE---LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2412 A +R +E LF + ++++L + A E + L LQE + ++ Sbjct: 1673 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE---RFRE 1729 Query: 2413 VAEEAARLSVAAQEAARLRQLAEE----------DLAQQRALAEKMLKEKMQAVQEATRL 2462 A + ++ + + LA+E +A+ + + + ++ + T++ Sbjct: 1730 FARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI 1787 Query: 2463 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA------EETQGFQRTLEAERQ------ 2510 A + L + A+E R+Q+ +++ ++L E Q T E + Q Sbjct: 1788 LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV 1847 Query: 2511 RQLEMSA----------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR---- 2556 RQL+ A +A+ ++ R E+ A + + R + + G+K Sbjct: 1848 RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV 1907 Query: 2557 -----------TELATQEKVTLVQTLEI-----QRQQSDHDA------------------ 2582 ++ QEK V ++E+ Q +++ DA Sbjct: 1908 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1967 Query: 2583 -----ERLREAIAEL-EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2633 E ++E + +L E+ KE K + + L+L E Q + + + Q+ +L Sbjct: 1968 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2027 Query: 2634 S---------EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2684 S E + L++R E+ A ++ F + + L + R+QQ+ E+ER+R Sbjct: 2028 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKR 2085 Query: 2685 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2722 S E + + EAE + + +Q+ Q E+ Sbjct: 2086 RPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQ 2123 Score = 100 bits (249), Expect = 3e-20 Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%) Query: 1303 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1362 R G+ ++ + ER+ + + L +RQ +LEQL R R+ R++A WL + Sbjct: 371 REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 427 Query: 1363 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1412 +R Q D AV ++ +A+ +I + E+V+ A++ Sbjct: 428 NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 485 Query: 1413 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1470 I A KD ++L Y LE + + ++ ++ G + + QE + + E+ L+ Y Sbjct: 486 ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 543 Query: 1471 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1530 K + + + ++ L E + ER+ V A+ +K E + Q R+ Sbjct: 544 GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 602 Query: 1531 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1588 + +E+ + ++R+ EE ++L + AE + R+ E S + Sbjct: 603 MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 655 Query: 1589 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1646 + V+RL + A E + G G + E+ A++ +E++R ++ R Sbjct: 656 DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 710 Query: 1647 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706 ++ A +E S ++ +++ L + + A++ + + ++ + V + Sbjct: 711 EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 760 Query: 1707 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1766 + L K AE+ A +L H E+A Q+ AE+ R Sbjct: 761 HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 813 Query: 1767 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1820 ER++ + E RLR QA + +A K ++A+A + +KE+ + K E+ Sbjct: 814 IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 872 Query: 1821 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1875 V Q E E Q + ++A + +E E QQ +L EL Sbjct: 873 VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 932 Query: 1876 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931 +++A +A + + LE K +R + +V+ +++ + + + + K G Sbjct: 933 RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 987 Query: 1932 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1991 R+L A+L L +EA E + + + + +LA I + E + Sbjct: 988 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1036 Query: 1992 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 2045 LK +EA E +L++ D + FQ Q A D+ L + K ++ Sbjct: 1037 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1096 Query: 2046 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 2092 + E+ ++ R Q + + + L+ + G EL ++ R N Sbjct: 1097 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1155 Query: 2093 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 2148 + LR +QAE Q + A E + +L E A ++++ + + Sbjct: 1156 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1206 Query: 2149 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2204 E++ A VE RRL S R + + + E A ++ K+ ++LQ+ Sbjct: 1207 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1266 Query: 2205 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260 LQ Q + +++ + + A ++ + A+ E +++++ + Sbjct: 1267 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1326 Query: 2261 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2309 + + +A E L + +A R A +A L + AD + H Sbjct: 1327 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1384 Query: 2310 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2366 ++ Q ++LT++ + L++ ++Q + +E++ L+++A +A Q + +E Sbjct: 1385 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1442 Query: 2367 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2419 + S R VQ + + L+ E ++ L ++ R +++E E+M + + Sbjct: 1443 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1502 Query: 2420 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2479 Q + Q ++++ + + + + V +++ L AEA Sbjct: 1503 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1549 Query: 2480 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2535 R+ D +Q+ L EET+ R L EA R +Q AEA + + MS +A+ Sbjct: 1550 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1609 Query: 2536 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2586 E+ A Q + E+ E +H+ ++ V + ++ I +QS D +L Sbjct: 1610 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1667 Query: 2587 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2642 + +L E+ KL + +L QL E Q + + +++ + L Q + E ++LQ Sbjct: 1668 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1724 Query: 2643 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2682 ERF I QE+ DE +A+ + E ++ R Sbjct: 1725 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1784 Query: 2683 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2739 +++A+ E + H+A+E R Q++ ++L ++ + + E L + +Q L Sbjct: 1785 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1844 Query: 2740 EQHR 2743 Q R Sbjct: 1845 TQVR 1848 Score = 100 bits (249), Expect = 3e-20 Identities = 295/1531 (19%), Positives = 569/1531 (37%), Gaps = 279/1531 (18%) Query: 514 ILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAG 573 I ER +R ++ LE L I K EA L + AD + D +L K+ + Sbjct: 702 IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDI---DAWMLDILKIVS-SS 757 Query: 574 EVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEY----NLRL 629 +V D S+++ + + + + R + LHE+ A+ E+ ++R Sbjct: 758 DVGHDEYSTQSLVKKHKDVAEEIANYRPT--------LDTLHEQASALPQEHAESPDVRG 809 Query: 630 K-AGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA-----WVEENQHRVDGAEWGV 683 + +G+ +VA++T R+ L+D+ Y A W++E + ++ + Sbjct: 810 RLSGIEERYKEVAELTRL---RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 866 Query: 684 DLPSVEAQLGSHRGLHQSIEEFRAK------IERARSDEGQLSPATRGAYRDCLGRLDLQ 737 L +E L + ++ I R G S A +D L Q Sbjct: 867 KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 926 Query: 738 YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE-EVGFDWSDRNTNMTAKKESYS 796 + +L++ K L S S+ ++ + W+ EK + E D + + A + + Sbjct: 927 FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 986 Query: 797 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 856 + R+L E K+ +LQ ++L E + S A + W M EA L Sbjct: 987 GMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLG 1046 Query: 857 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 916 E + QF D+ + + L + Q A+ + D T+T E LL ++ K +++ Y+ Sbjct: 1047 EASKLQQFLRDLDDFQSWLSRTQTAIASE---DMPNTLTEAEKLLTQHENIKNEIDNYEE 1103 Query: 917 HLSGLAKRAKAVVQ---------LKPRHPA--------HPM-RGRLPLLA--------VC 950 + + V Q L+ R A H M R LL+ + Sbjct: 1104 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1163 Query: 951 DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSV--CFLVPPPNQEA------ 1002 D KQ E ++ E L P+ + G+EAA+ N+E Sbjct: 1164 DTKQAEAFLNN-QEYVLAHTEMPT-----TLEGAEAAIKKQEDFMTTMDANEEKINAVVE 1217 Query: 1003 ----------------QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1046 QE V ++ +H+ +L + +K Q +D Q + W Sbjct: 1218 TGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLW 1277 Query: 1047 ---SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQ 1103 + T + + +E R LHS L +QAF+ + L + +E+ Sbjct: 1278 INEKMLTAQDMSYDEARN-LHSKWLKHQAFMAE------------LASNKEW------LD 1318 Query: 1104 QLLQSLEQGAQEESRCQRCISE-LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1162 ++ + Q E+ + + E L + E E+ T + + D A Q A+ Sbjct: 1319 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1378 Query: 1163 QQK------AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR- 1215 K +Q + + GK + ++ +K L EL+ L Q Sbjct: 1379 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1438 Query: 1216 ----------SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP----- 1260 ++ ++E L+ ++ ++E+ + + + E V +P Sbjct: 1439 STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATST 1498 Query: 1261 ----ELEATKASLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVE 1312 L+ + +KK L+ + + QP D ++ ER Q + + E Sbjct: 1499 DHGHNLQTVQLLIKKNQTLQKEIQGHQPRID----------DIFERSQNIVTDSSSLSAE 1548 Query: 1313 RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1372 R+R+A L + W ++ +T+ R R LE+ R +YY ++A+ AW+ + + + Sbjct: 1549 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA-EAWMSE--QELYMMSE 1605 Query: 1373 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1432 D Q+ L++ Q L + +E + E V + + ++ + A E + ++ + Sbjct: 1606 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALV-ADSHPESERISMRQ---- 1660 Query: 1433 VASPAKKPKVQSGSESVIQEY---VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489 +K K+ +G + + +E +D R +L ++I+E E Sbjct: 1661 ----SKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAE------REVVAGS 1710 Query: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA-AVDA 1548 + ++ E + ++ E+ R+ A + +E + + +E++ + A Sbjct: 1711 HELGQDYEHVTMLQ---ERFREFA----RDTGNIGQERVDTVNHLADELINSGHSDAATI 1763 Query: 1549 QQQKRSIQEELQQLRQSSEAEIQAKARQAEA-------------AERSRLRIEEEIRVVR 1595 + K + E L + + Q A E + ++ EE+ + Sbjct: 1764 AEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQ 1823 Query: 1596 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEV 1652 +E +R E ++QAL Q RQ QE+A RL+ + +KR+ EV Sbjct: 1824 NTVETLQRMHTTFEHDIQALGT-------QVRQLQEDAARLQAAYAGDKADDIQKRENEV 1876 Query: 1653 ELASRVKAEAEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1704 A + +A +R +K R + +L L E+ R++ E R L Sbjct: 1877 LEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELL 1936 Query: 1705 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1764 + +AE+ ++ SF + L +H A +++E+ + E+ +E Sbjct: 1937 MNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT------EKRKEMI 1990 Query: 1765 ERELERWQLKANEALRLRLQAEEVAQQKSLAQA-------------------EAEK---- 1801 ++ +RW E LRL L+ + ++ S+A+A E EK Sbjct: 1991 DKWEDRW-----EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKR 2045 Query: 1802 -----------------------------QKEEAEREARRRGKAEEQAVRQRELAEQELE 1832 ++++ E E +RR + E + + E AE + + Sbjct: 2046 HEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQ 2105 Query: 1833 KQRQLAEGTAQQRLAAEQELIRL--RAETEQ 1861 E +Q L AEQ R+ R++T Q Sbjct: 2106 WDTSKGEQVSQNGLPAEQGSPRVSYRSQTYQ 2136 >gi|67782321 spectrin beta isoform a [Homo sapiens] Length = 2328 Score = 374 bits (959), Expect = e-102 Identities = 527/2195 (24%), Positives = 902/2195 (41%), Gaps = 277/2195 (12%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233 DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP+ KG+MR Sbjct: 50 DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109 Query: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292 H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V Q Sbjct: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169 Query: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351 E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID +K+ Sbjct: 170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229 Query: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410 NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++ + +G R Sbjct: 230 ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289 Query: 411 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463 A E + ++Y L LL W+ R+F +S ++ F ++ Sbjct: 290 VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349 Query: 464 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520 +E P K +K + + +++ ++A KV G D+ + W L A RE Sbjct: 350 VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409 Query: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577 LR+E R E L+++ + +A + E L++ L+ D L A ++ +E Sbjct: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469 Query: 578 DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 636 D + +R L + Q L K+ H Q + + R + LRL Sbjct: 470 DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509 Query: 637 ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 693 Q LQS ++R E + + QD+L W++E + + AE+G L VE L Sbjct: 510 -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568 Query: 694 SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 745 H+ + I K++ + EG+ P +D + L+ + +L N + Sbjct: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628 Query: 746 -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804 KA+L + L F + W+ EKE+ D+ T++ + + A EL Sbjct: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688 Query: 805 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864 + ++++ ++ P +E+ + QW + L + +L++ +FQF Sbjct: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748 Query: 865 FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 923 D + + LQ L D AT L + +D E+L E +G + L + Sbjct: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804 Query: 924 RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 968 +A+ + P H ++ L +A D +Q + + D C+L + Sbjct: 805 QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864 Query: 969 GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 1001 G + K L + G A S+ P ++E Sbjct: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924 Query: 1002 AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 1037 ++ L + QA TL H VD + W + L Sbjct: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984 Query: 1038 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1097 RD+ I +A R L E+ A +++ A R+SQ PE + + G Sbjct: 985 RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034 Query: 1098 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150 H ++L Q L+Q Q E S+ Q + +L D + L + + V +P Sbjct: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090 Query: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1205 E E Q + + + E++G R+ EKV+ + P L LE Sbjct: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149 Query: 1206 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264 LG++ + RS + L + + + AE +L E L + + LEA Sbjct: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202 Query: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 +A ++K E + + RD++ + G +L E ++ ++ +E+V + +R Sbjct: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255 Query: 1325 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381 + + + + +E L R +L+ + ++ L W+ D + + +++ + Sbjct: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308 Query: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1435 + + QA + E+ H +E KQ ++ K LV+ K + E A+ Sbjct: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367 Query: 1436 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1495 +K + S + S + L+TH +++I + + LR + + L R Sbjct: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419 Query: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1550 + + E + + K+ +L E AQ + E +++R + E + R + +++ + Sbjct: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478 Query: 1551 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1602 K I +L ++L + A+ + + + ++ EI ++E Sbjct: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537 Query: 1603 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1661 QRG + ++A ++ E + Q +RLR QR R A + A E Sbjct: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595 Query: 1662 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1715 AEA +Q +E+ E A +R LRQ A + R ++ AQ L Sbjct: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650 Query: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775 S E+ +L+ + + + + + EE +R+ + + + E + +LE+W Sbjct: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705 Query: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835 + E VA + Q + R+ R E A+ Q + +R Sbjct: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756 Query: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1888 + G ++ AE + E LLE R+Q AA+ R Sbjct: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809 Query: 1889 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947 L E + E L AS A + + E+ L + +F+++A A Sbjct: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868 Query: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007 E+A+ + +E +A +A + A G T+L A +K R L Sbjct: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916 Query: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 2060 R++E Q E L + + ++E+E R K L E L+++ Q Sbjct: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976 Query: 2061 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 2116 EEI L+ + + E R+R E S++ + EA A++ LA+ + Sbjct: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036 Query: 2117 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173 ++ E++ K A E++ +R AALE+ L+ K R++ ER +E+ Q Sbjct: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093 Query: 2174 QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2208 + + A + + + ++E Q LQQ Sbjct: 2094 EEGETAGEAPVSHHAATERTSPGEEEGTWPQNLQQ 2128 Score = 101 bits (251), Expect = 2e-20 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%) Query: 1288 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1347 D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R + Sbjct: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641 Query: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1399 ++ E D +W+++ + + S +A ++LR A LE+I + Sbjct: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700 Query: 1400 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1457 + ++F I A IK+ Q QL+ +A+ KK + + Q + DL+ Sbjct: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756 Query: 1458 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1517 + L S E + + E R ++ + E L E +E Q A Sbjct: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806 Query: 1518 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575 Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A Sbjct: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860 Query: 1576 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1635 + E+ + E E+ LE + + + E++ L + + E Sbjct: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920 Query: 1636 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1686 R+V QD + QA L S + ++A EE + + E+ Sbjct: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980 Query: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746 + L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++ Sbjct: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038 Query: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806 E Q ++ + +E+ E+ QL+A QA QK++A + + EA Sbjct: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096 Query: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1861 E+ ++ +++ ++ ++ E ++ +G T + L Q L L A Sbjct: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156 Query: 1862 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1917 E + L + L Q++A A E LA + + L A++A R E+ Sbjct: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215 Query: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977 + E ++ ++ + +L E +++ K + QL E+ + +A+ E Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268 Query: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037 + + L+ + + N++L + + R L + +H+A + Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319 Query: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097 +EL +G +E+ + +Q+ +E K F + K E L R+ + T + Sbjct: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369 Query: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2155 K Q L AAR L R + + K ++A E+ R L V R+ AK+ Sbjct: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421 Query: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215 + +Q + R+ +L + AQ EE A L E+ LD Sbjct: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463 Query: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275 L E R+ E+ A++Q R+ VEE L QSA+ Sbjct: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506 Query: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335 Q Q +++ Q E+ H E L++ Q+ + LEE Sbjct: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558 Query: 2336 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2385 D + LQRL+ +A EA Q+ ++ + + +EL + I + Sbjct: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615 Query: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2441 E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A Sbjct: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675 Query: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2482 + +AE+ K K++ + +LK E + L+Q +KEL +++ R Sbjct: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734 Query: 2483 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2536 + + Q+ + F +R ++A ++ + L A++ +R Q A Sbjct: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794 Query: 2537 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2574 D R+ R+ E++G E HR A + ++ L L +Q Sbjct: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2625 QQ A RL+ A A ++A+ +Q K +E+ Q L L +T Sbjct: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902 Query: 2626 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685 + F +D L E I Q + Q +V+ + L + Q ++E + Sbjct: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959 Query: 2686 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742 A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ + Sbjct: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016 Query: 2743 RAALAHS 2749 A++A + Sbjct: 2017 DASVAEA 2023 Score = 78.2 bits (191), Expect = 2e-13 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%) Query: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1467 ++++ N++ + QL + + K PK Q G+ V+ + R + T Sbjct: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382 Query: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1527 K +S+ R E E ++ R L E K QLA + A E Sbjct: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438 Query: 1528 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1576 E Q+ + ++ + AAV+A ++K E L+ L Q E E ++ Sbjct: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498 Query: 1577 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1632 A + + LR ++E ++ R +LE T + + L ++ +E +A A+ Sbjct: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557 Query: 1633 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1672 L +V+D Q+ + E ++A +VKA + + +++ L Sbjct: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615 Query: 1673 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1715 Q EEL A + +L Q++ ++ Q+ +L+ + ++ L Sbjct: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675 Query: 1716 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1757 Q K +F ++ A LE+ QE H VA+ + + E R ++ A Sbjct: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735 Query: 1758 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808 ++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E Sbjct: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791 Query: 1809 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853 RG E+QA V R A +EL +Q QQRL +L Sbjct: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851 Query: 1854 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908 + ET+ GE+++ L E E+ + + L+ E+ + +++ + + Sbjct: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911 Query: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968 E S + KQ + R++ + R + A R + E Sbjct: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966 Query: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 2026 + + +K + E+ + R LA A QR+ LE A +A Sbjct: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009 Query: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086 ++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+ Sbjct: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061 Query: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146 ++++ +D QA L + Q+ +A+E+ + +SL E+ +Q + Sbjct: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108 Query: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2194 E++ + +R++E E+ Q +RL+ E ++H A Sbjct: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165 Query: 2195 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2245 QE Q+ +Q +++L EAA + E+ E + Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225 Query: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305 V+ +L A+ + EK++ ++ +A++A++ + + + Sbjct: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277 Query: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2365 F + + +L T Q D +NL ++ L+ +A E A +E Sbjct: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331 Query: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425 + M+E + A + + AL R D Q +E+ + + RL A Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390 Query: 2426 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2479 +A QL +D + +ML K++ V++ ++ E EL Q + E+ Sbjct: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448 Query: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2537 E+ L E ++ LE+ R + L++S + E L V E A+ Sbjct: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507 Query: 2538 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2583 + Q F K+ + + ++ R E Q LV+ EI Q + + Sbjct: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567 Query: 2584 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2638 RLREA A L+R ++ EA+ L ++E + EQ L E ++ + Sbjct: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625 Query: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698 L+++R +E ++QL ++AQ L + +Q+ RL +++ + Sbjct: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677 Query: 2699 AEEGVRRKQEELQQLEQQRRQQEEL 2723 E +RK E + L Q +R+ ++L Sbjct: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702 Score = 77.8 bits (190), Expect = 2e-13 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%) Query: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868 E +R GK + A+ E EK + G A L ++ I + + Sbjct: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329 Query: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1925 L +Q++ A + R + + + +EVLL S+ RA + T K Sbjct: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387 Query: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985 L ++ R E EEA R LA + RQ E AR+ +R A + + E RL Sbjct: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444 Query: 1986 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 2040 + L EA ++ + D A R LE+ A + + + ++ D Sbjct: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504 Query: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 2092 + L R +++ L+ RRQ E LAL+ F+ KA L E G+ Sbjct: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563 Query: 2093 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2149 ED L+ + E + A Q ++ A + E + + + ++ + EE+ Sbjct: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623 Query: 2150 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2203 + KA++E+++RL + E + A +E L ++ +Q+K + + Sbjct: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683 Query: 2204 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260 L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + + Sbjct: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740 Query: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2319 A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ + Sbjct: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798 Query: 2320 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2370 +EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V Sbjct: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857 Query: 2371 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427 + M E K A +E + L D + Q ++MK + + +++AA Sbjct: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914 Query: 2428 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480 R R++ + + L + + ++ E+ +AV A R+ ++ + ++ Sbjct: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974 Query: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540 + ++ K+ + + LA QR L + + A + L+ ++ + +ED Sbjct: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032 Query: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2597 + +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091 Query: 2598 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2651 L + +LLQ +K E Q ++E+ + +Q E L QR ++ Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151 Query: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2707 L ++++ Q Q+ Q+ + E Q + E AE G+R+ + Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211 Query: 2708 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2753 + L +E R + +L+AE N +++E++QL+E++HR ++E + Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267 Score = 75.1 bits (183), Expect = 2e-12 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%) Query: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2137 E E R + + +R ++ +L R+ A E E +R A++ LAA E A Sbjct: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460 Query: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2193 ++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++ Sbjct: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512 Query: 2194 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2248 +Q + Q L+ TL ++ D L + + AE + E E + ++ Sbjct: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572 Query: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2303 EA+ Q + +A A + K + + + R + EQ A A+ Sbjct: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632 Query: 2304 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2345 +E+ K+ AE +++K Q+ L + L LQ + + L LD Sbjct: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692 Query: 2346 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401 L+++ EA ++ Q+E + V Q ++L L A + L+D +N + Sbjct: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747 Query: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461 F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E Sbjct: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794 Query: 2462 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514 + E L+QQ + E+ R RLQ +E Q +A+ QR EA Sbjct: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852 Query: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574 + E + +L + E + A E E++ HR ++ QE TL+ ++ Sbjct: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2630 ++ E E+++ ++ L + Q E + L + Sbjct: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967 Query: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690 ++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S Sbjct: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026 Query: 2691 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2748 E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+ Sbjct: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079 Query: 2749 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808 +++ AS+ ++LP L A + DG + S QR++E+G ++ Sbjct: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126 Query: 2809 LAQGHTTVDEL 2819 + QG T + L Sbjct: 1127 VIQGQTDPEYL 1137 Score = 74.3 bits (181), Expect = 3e-12 Identities = 302/1499 (20%), Positives = 557/1499 (37%), Gaps = 179/1499 (11%) Query: 1169 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1228 E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+ Sbjct: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742 Query: 1229 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1288 + QG + L+A + + + AT+A KK + E + Sbjct: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793 Query: 1289 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1348 E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++ Sbjct: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853 Query: 1349 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1408 + E+ D W+ + +++ + M + D+ LE++E Sbjct: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884 Query: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1465 Q+ I D E++ T Q++ V + A V+SG S V Q L T + T Sbjct: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941 Query: 1466 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512 L S+ Y ET + + ++ ++ E + R+ LA + A K L Sbjct: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000 Query: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1567 A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS + Sbjct: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056 Query: 1568 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1615 +++QA + QA + + E++ + E +Q G + E+ Q Sbjct: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116 Query: 1616 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1670 R +E+ + Q Q + E L R + D E S A+ +E Q+ Sbjct: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176 Query: 1671 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1723 A+ + +E L E L AE + + ++E + + + S A Sbjct: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236 Query: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1780 E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L Sbjct: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294 Query: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840 L Q + ++L + Q AE A G E ++L ++++ Q Sbjct: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349 Query: 1841 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1896 +Q+ A + L+A T++ Q RLQ A + + Q + K Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409 Query: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1951 + +LA R E++ E+ + E G +L+ E L L + Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469 Query: 1952 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 2004 R++QL A Q + E E + E+ + ++ T L+T K + +NE L Sbjct: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529 Query: 2005 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062 ED + ++L E A D+EERL L+ + D E G ++ R R E Sbjct: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586 Query: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122 + L A +A G+ EL + I + E + ++ RQ++ + R ++ Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642 Query: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2182 R Q L+A Q +V++ A +++ R+R + QL +E Sbjct: 1643 LASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL 1702 Query: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-EAARRAAEEAEEARVQAER-- 2239 EK + E+ Q + D+ R A E E + ER Sbjct: 1703 EQWISEK----ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLI 1758 Query: 2240 -----EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQA 2292 EAA + + E R Q AA+ L + E + Sbjct: 1759 DAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHR 1818 Query: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352 L + DA AE R E+EL L +Q+++ L KAE Sbjct: 1819 ELPEDVGLDAST------AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAE 1872 Query: 2353 ATE----------------AARQRSQVEE-----ELFSV-RVQMEELSKLKARIEAENRA 2390 A + A +R+Q+ + FS+ R + + + +IE + R Sbjct: 1873 AIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERP 1932 Query: 2391 LILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEK 2447 + + ++ Q AE + +A L + R Q +EE + QQ K Sbjct: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRK 1992 Query: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 + EK +A E RL+ E+ Q ++ + +A + ++ + ++ ++ Sbjct: 1993 EMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKR 2050 Query: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2566 + ++ AER A + + ++ Q + AEE G + E A + V+ Sbjct: 2051 HEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVS 2105 >gi|67782319 spectrin beta isoform b [Homo sapiens] Length = 2137 Score = 372 bits (956), Expect = e-102 Identities = 530/2201 (24%), Positives = 905/2201 (41%), Gaps = 280/2201 (12%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233 DER+ VQKKTFTKWVN HL + I+DLY+DLRDG LI LLEVLSG+ LP+ KG+MR Sbjct: 50 DEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLPKPTKGKMR 109 Query: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292 H L+NV AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI DI V Q Sbjct: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQEG 169 Query: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351 E +AK+ LLLW Q GY + NFTSSW+DG FNA+IH+H+P LID +K+ Sbjct: 170 RETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLIDFDKLKDSN 229 Query: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410 NL+ AF+VAER LG+ LLDPEDV PDEKSIITYV + Y ++ + +G R Sbjct: 230 ARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMKVLAVEGKR 289 Query: 411 -------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463 A E + ++Y L LL W+ R+F +S ++ F ++ Sbjct: 290 VGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQLQAFSTYRT 349 Query: 464 MELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHVAILEREKQ 520 +E P K +K + + +++ ++A KV G D+ + W L A RE Sbjct: 350 VEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEEAEYRRELA 409 Query: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577 LR+E R E L+++ + +A + E L++ L+ D L A ++ +E Sbjct: 410 LRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAKKKHEAIET 469 Query: 578 DLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAP 636 D + +R L + Q L K+ H Q + + R + LRL Sbjct: 470 DTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILRL------- 509 Query: 637 ATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDLPSVEAQLG 693 Q LQS ++R E + + QD+L W++E + + AE+G L VE L Sbjct: 510 -WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQ 568 Query: 694 SHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYAKLLNSS-- 745 H+ + I K++ + EG+ P +D + L+ + +L N + Sbjct: 569 KHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAG 628 Query: 746 -KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804 KA+L + L F + W+ EKE+ D+ T++ + + A EL Sbjct: 629 RKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRG 688 Query: 805 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864 + ++++ ++ P +E+ + QW + L + +L++ +FQF Sbjct: 689 LDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQDAENFFQF 748 Query: 865 FSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAK 923 D + + LQ L D AT L + +D E+L E +G + L + Sbjct: 749 QGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESRGVMEHLEQ 804 Query: 924 RAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHKGDECQL-V 968 +A+ + P H ++ L +A D +Q + + D C+L + Sbjct: 805 QAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGETDACELWM 864 Query: 969 GPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCFLVPPPNQE 1001 G + K L + G A S+ P ++E Sbjct: 865 GEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHPRSRE 924 Query: 1002 AQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW-----------QSLR 1037 ++ L + QA TL H VD + W + L Sbjct: 925 VKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLG 984 Query: 1038 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1097 RD+ I +A R L E+ A +++ A R+SQ PE + + G Sbjct: 985 RDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK----EDIGQ 1034 Query: 1098 CSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 1150 H ++L Q L+Q Q E S+ Q + +L D + L + + V +P Sbjct: 1035 RQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVASEDMP--- 1090 Query: 1151 EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELE----- 1205 E E Q + + + E++G R+ EKV+ + P L LE Sbjct: 1091 ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQRLEGLDTG 1149 Query: 1206 -LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264 LG++ + RS + L + + + AE +L E L + + LEA Sbjct: 1150 WNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDS----LEA 1202 Query: 1265 TKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 +A ++K E + + RD++ + G +L E ++ ++ +E+V + +R Sbjct: 1203 AEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKEKVQLIEDR 1255 Query: 1325 WQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1381 + + + + +E L R +L+ + ++ L W+ D + + +++ + Sbjct: 1256 HR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS---YDEARNL 1308 Query: 1382 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL------EPVAS 1435 + + QA + E+ H +E KQ ++ K LV+ K + E A+ Sbjct: 1309 HNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHRLWDELQAT 1367 Query: 1436 PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1495 +K + S + S + L+TH +++I + + LR + + L R Sbjct: 1368 TKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDLTSVNRMLA 1419 Query: 1496 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRREEAAVDAQQ 1550 + + E + + K+ +L E AQ + E +++R + E + R + +++ + Sbjct: 1420 KLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRRKKQLESSR 1478 Query: 1551 QKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE 1602 K I +L ++L + A+ + + + ++ EI ++E Sbjct: 1479 AKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGHTPRVEDV- 1537 Query: 1603 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKA-E 1661 QRG + ++A ++ E + Q +RLR QR R A + A E Sbjct: 1538 LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQQYYLDADE 1595 Query: 1662 AEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETAQRSAEAEL 1715 AEA +Q +E+ E A +R LRQ A + R ++ AQ L Sbjct: 1596 AEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQ-----GL 1650 Query: 1716 QSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1775 S E+ +L+ + + + + + EE +R+ + + + E + +LE+W Sbjct: 1651 LSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-DLEQW---- 1705 Query: 1776 NEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR 1835 + E VA + Q + R+ R E A+ Q + +R Sbjct: 1706 ------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIER 1756 Query: 1836 QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQ------- 1888 + G ++ AE + E LLE R+Q AA+ R Sbjct: 1757 LIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEI 1809 Query: 1889 -ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA 1947 L E + E L AS A + + E+ L + +F+++A A Sbjct: 1810 LGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYA-G 1868 Query: 1948 EEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLA 2007 E+A+ + +E +A +A + A G T+L A +K R L Sbjct: 1869 EKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRFFSMARDLL 1916 Query: 2008 EDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVEDTLRQRRQV 2060 R++E Q E L + + ++E+E R K L E L+++ Q Sbjct: 1917 SWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQA 1976 Query: 2061 EEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---ARQRQLAAEE 2116 EEI L+ + + E R+R E S++ + EA A++ LA+ + Sbjct: 1977 SEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQEPYLASGD 2036 Query: 2117 ERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERAEQESARQL 2173 ++ E++ K A E++ +R AALE+ L+ K R++ ER +E+ Q Sbjct: 2037 FGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERPAEETGPQE 2093 Query: 2174 ---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211 + A EA A E+ ++ + ++LQ E S Sbjct: 2094 EEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134 Score = 101 bits (251), Expect = 2e-20 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%) Query: 1288 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1347 D+++ + + G + + + ++R++ L + ++ + R+ +LEQ R + Sbjct: 582 DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641 Query: 1348 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1399 ++ E D +W+++ + + S +A ++LR A LE+I + Sbjct: 642 FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700 Query: 1400 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1457 + ++F I A IK+ Q QL+ +A+ KK + + Q + DL+ Sbjct: 701 HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756 Query: 1458 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1517 + L S E + + E R ++ + E L E +E Q A Sbjct: 757 AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806 Query: 1518 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1575 Q + R++ ++ R+Q E+ ++ A D +QQ+ +QE L E + A Sbjct: 807 QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860 Query: 1576 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1635 + E+ + E E+ LE + + + E++ L + + E Sbjct: 861 ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920 Query: 1636 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1686 R+V QD + QA L S + ++A EE + + E+ Sbjct: 921 RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980 Query: 1687 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1746 + L + ++ +Q L +R A +Q++ + ++ QL S E+ + Q ++ Sbjct: 981 KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038 Query: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1806 E Q ++ + +E+ E+ QL+A QA QK++A + + EA Sbjct: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096 Query: 1807 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1861 E+ ++ +++ ++ ++ E ++ +G T + L Q L L A Sbjct: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156 Query: 1862 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1917 E + L + L Q++A A E LA + + L A++A R E+ Sbjct: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215 Query: 1918 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1977 + E ++ ++ + +L E +++ K + QL E+ + +A+ E Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268 Query: 1978 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 2037 + + L+ + + N++L + + R L + +H+A + Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319 Query: 2038 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 2097 +EL +G +E+ + +Q+ +E K F + K E L R+ + T + Sbjct: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369 Query: 2098 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 2155 K Q L AAR L R + + K ++A E+ R L V R+ AK+ Sbjct: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421 Query: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2215 + +Q + R+ +L + AQ EE A L E+ LD Sbjct: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463 Query: 2216 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2275 L E R+ E+ A++Q R+ VEE L QSA+ Sbjct: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506 Query: 2276 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2335 Q Q +++ Q E+ H E L++ Q+ + LEE Sbjct: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558 Query: 2336 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2385 D + LQRL+ +A EA Q+ ++ + + +EL + I + Sbjct: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615 Query: 2386 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2441 E ++L+ QR +++ +KQ+A A L A ++ RL+ ++ A Sbjct: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675 Query: 2442 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2482 + +AE+ K K++ + +LK E + L+Q +KEL +++ R Sbjct: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734 Query: 2483 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2536 + + Q+ + F +R ++A ++ + L A++ +R Q A Sbjct: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794 Query: 2537 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2574 D R+ R+ E++G E HR A + ++ L L +Q Sbjct: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2625 QQ A RL+ A A ++A+ +Q K +E+ Q L L +T Sbjct: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902 Query: 2626 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2685 + F +D L E I Q + Q +V+ + L + Q ++E + Sbjct: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959 Query: 2686 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2742 A +E +RQH+A E +R E+LQQ+ +R++ E +RLR L++ + Sbjct: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016 Query: 2743 RAALAHS 2749 A++A + Sbjct: 2017 DASVAEA 2023 Score = 78.2 bits (191), Expect = 2e-13 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%) Query: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1467 ++++ N++ + QL + + K PK Q G+ V+ + R + T Sbjct: 327 SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382 Query: 1468 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1527 K +S+ R E E ++ R L E K QLA + A E Sbjct: 383 PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438 Query: 1528 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1576 E Q+ + ++ + AAV+A ++K E L+ L Q E E ++ Sbjct: 439 SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498 Query: 1577 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1632 A + + LR ++E ++ R +LE T + + L ++ +E +A A+ Sbjct: 499 ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557 Query: 1633 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1672 L +V+D Q+ + E ++A +VKA + + +++ L Sbjct: 558 KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615 Query: 1673 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1715 Q EEL A + +L Q++ ++ Q+ +L+ + ++ L Sbjct: 616 EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675 Query: 1716 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1757 Q K +F ++ A LE+ QE H VA+ + + E R ++ A Sbjct: 676 QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735 Query: 1758 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1808 ++ ++AE +L+ W +A RL L E+V Q + +A +K K+ E Sbjct: 736 KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791 Query: 1809 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853 RG E+QA V R A +EL +Q QQRL +L Sbjct: 792 LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851 Query: 1854 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908 + ET+ GE+++ L E E+ + + L+ E+ + +++ + + Sbjct: 852 TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911 Query: 1909 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1968 E S + KQ + R++ + R + A R + E Sbjct: 912 NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966 Query: 1969 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 2026 + + +K + E+ + R LA A QR+ LE A +A Sbjct: 967 SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009 Query: 2027 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 2086 ++ + ++ DS E++ ED ++++ +EE L +++ G+ +L E+ Sbjct: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061 Query: 2087 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 2146 ++++ +D QA L + Q+ +A+E+ + +SL E+ +Q + Sbjct: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108 Query: 2147 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2194 E++ + +R++E E+ Q +RL+ E ++H A Sbjct: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165 Query: 2195 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2245 QE Q+ +Q +++L EAA + E+ E + Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225 Query: 2246 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2305 V+ +L A+ + EK++ ++ +A++A++ + + + Sbjct: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277 Query: 2306 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2365 F + + +L T Q D +NL ++ L+ +A E A +E Sbjct: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331 Query: 2366 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2425 + M+E + A + + AL R D Q +E+ + + RL A Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390 Query: 2426 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2479 +A QL +D + +ML K++ V++ ++ E EL Q + E+ Sbjct: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448 Query: 2480 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2537 E+ L E ++ LE+ R + L++S + E L V E A+ Sbjct: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507 Query: 2538 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2583 + Q F K+ + + ++ R E Q LV+ EI Q + + Sbjct: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567 Query: 2584 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2638 RLREA A L+R ++ EA+ L ++E + EQ L E ++ + Sbjct: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625 Query: 2639 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2698 L+++R +E ++QL ++AQ L + +Q+ RL +++ + Sbjct: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677 Query: 2699 AEEGVRRKQEELQQLEQQRRQQEEL 2723 E +RK E + L Q +R+ ++L Sbjct: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702 Score = 77.8 bits (190), Expect = 2e-13 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%) Query: 1809 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1868 E +R GK + A+ E EK + G A L ++ I + + Sbjct: 286 EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329 Query: 1869 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1925 L +Q++ A + R + + + +EVLL S+ RA + T K Sbjct: 330 FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387 Query: 1926 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1985 L ++ R E EEA R LA + RQ E AR+ +R A + + E RL Sbjct: 388 LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444 Query: 1986 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 2040 + L EA ++ + D A R LE+ A + + + ++ D Sbjct: 445 VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504 Query: 2041 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 2092 + L R +++ L+ RRQ E LAL+ F+ KA L E G+ Sbjct: 505 NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563 Query: 2093 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 2149 ED L+ + E + A Q ++ A + E + + + ++ + EE+ Sbjct: 564 EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623 Query: 2150 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2203 + KA++E+++RL + E + A +E L ++ +Q+K + + Sbjct: 624 NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683 Query: 2204 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2260 L+ + L+Q+ EA A ++ EAR+ +E + Q+++ + + Sbjct: 684 DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740 Query: 2261 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2319 A+ Q Q A+ L K Q+A R E + + A A +KHK F E+ + Sbjct: 741 DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798 Query: 2320 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2370 +EQ+ + ++ H+ L E Q++ A+A + +QR Q +L++V Sbjct: 799 MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857 Query: 2371 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2427 + M E K A +E + L D + Q ++MK + + +++AA Sbjct: 858 DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914 Query: 2428 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2480 R R++ + + L + + ++ E+ +AV A R+ ++ + ++ Sbjct: 915 VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974 Query: 2481 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2540 + ++ K+ + + LA QR L + + A + L+ ++ + +ED Sbjct: 975 KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032 Query: 2541 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2597 + +K EE+ + L ++ ++ + V L+ Q D L ++A+A E E Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091 Query: 2598 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2651 L + +LLQ +K E Q ++E+ + +Q E L QR ++ Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151 Query: 2652 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2707 L ++++ Q Q+ Q+ + E Q + E AE G+R+ + Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211 Query: 2708 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2753 + L +E R + +L+AE N +++E++QL+E++HR ++E + Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267 Score = 75.1 bits (183), Expect = 2e-12 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%) Query: 2082 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 2137 E E R + + +R ++ +L R+ A E E +R A++ LAA E A Sbjct: 401 EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460 Query: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2193 ++ +A +E A EE R RA ++ A++L+ QKR+ A + + ++ Sbjct: 461 KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512 Query: 2194 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2248 +Q + Q L+ TL ++ D L + + AE + E E + ++ Sbjct: 513 LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572 Query: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2303 EA+ Q + +A A + K + + + R + EQ A A+ Sbjct: 573 MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632 Query: 2304 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2345 +E+ K+ AE +++K Q+ L + L LQ + + L LD Sbjct: 633 LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692 Query: 2346 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401 L+++ EA ++ Q+E + V Q ++L L A + L+D +N + Sbjct: 693 LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747 Query: 2402 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2461 F Q +A+ +K ++A RL L+ ED+ Q + K+ ++E Sbjct: 748 F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794 Query: 2462 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514 + E L+QQ + E+ R RLQ +E Q +A+ QR EA Sbjct: 795 SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852 Query: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574 + E + +L + E + A E E++ HR ++ QE TL+ ++ Sbjct: 853 VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907 Query: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2630 ++ E E+++ ++ L + Q E + L + Sbjct: 908 NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967 Query: 2631 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2690 ++++K +++ + + ++ A + + Q +++ ++ Q + +E+E Q+L+ S Sbjct: 968 KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026 Query: 2691 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2748 E + + G R+K EEL Q L+Q + QE+LL E +Q L+ LQ L++ +A L+ Sbjct: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079 Query: 2749 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808 +++ AS+ ++LP L A + DG + S QR++E+G ++ Sbjct: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126 Query: 2809 LAQGHTTVDEL 2819 + QG T + L Sbjct: 1127 VIQGQTDPEYL 1137 Score = 74.3 bits (181), Expect = 3e-12 Identities = 302/1499 (20%), Positives = 557/1499 (37%), Gaps = 179/1499 (11%) Query: 1169 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1228 E+ GL + ++ EA ++A + P + + ++ + +Q++ L+A + L+ Sbjct: 685 ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742 Query: 1229 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1288 + QG + L+A + + + AT+A KK + E + Sbjct: 743 ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793 Query: 1289 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1348 E RG E E+ Q E + R+ L E +Q V+AQ D+RQ+ L++ Sbjct: 794 ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853 Query: 1349 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1408 + E+ D W+ + +++ + M + D+ LE++E Sbjct: 854 FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884 Query: 1409 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1465 Q+ I D E++ T Q++ V + A V+SG S V Q L T + T Sbjct: 885 VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941 Query: 1466 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1512 L S+ Y ET + + ++ ++ E + R+ LA + A K L Sbjct: 942 LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000 Query: 1513 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1567 A +A+ + +E QQ M ++E D Q+++ ++E Q L+QS + Sbjct: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056 Query: 1568 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1615 +++QA + QA + + E++ + E +Q G + E+ Q Sbjct: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116 Query: 1616 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1670 R +E+ + Q Q + E L R + D E S A+ +E Q+ Sbjct: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176 Query: 1671 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1723 A+ + +E L E L AE + + ++E + + + S A Sbjct: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236 Query: 1724 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1780 E ++ ++E+ + + +AQ+ + R E + L+ Q L N+ L Sbjct: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294 Query: 1781 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1840 L Q + ++L + Q AE A G E ++L ++++ Q Sbjct: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349 Query: 1841 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1896 +Q+ A + L+A T++ Q RLQ A + + Q + K Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409 Query: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1951 + +LA R E++ E+ + E G +L+ E L L + Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469 Query: 1952 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 2004 R++QL A Q + E E + E+ + ++ T L+T K + +NE L Sbjct: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529 Query: 2005 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 2062 ED + ++L E A D+EERL L+ + D E G ++ R R E Sbjct: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586 Query: 2063 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 2122 + L A +A G+ EL + I + E + ++ RQ++ + R ++ Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642 Query: 2123 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2182 R Q L+A Q +V++ A +++ R+R + QL +E Sbjct: 1643 LASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL 1702 Query: 2183 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-EAARRAAEEAEEARVQAER-- 2239 EK + E+ Q + D+ R A E E + ER Sbjct: 1703 EQWISEK----ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLI 1758 Query: 2240 -----EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQA 2292 EAA + + E R Q AA+ L + E + Sbjct: 1759 DAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHR 1818 Query: 2293 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2352 L + DA AE R E+EL L +Q+++ L KAE Sbjct: 1819 ELPEDVGLDAST------AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAE 1872 Query: 2353 ATE----------------AARQRSQVEE-----ELFSV-RVQMEELSKLKARIEAENRA 2390 A + A +R+Q+ + FS+ R + + + +IE + R Sbjct: 1873 AIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERP 1932 Query: 2391 LILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEK 2447 + + ++ Q AE + +A L + R Q +EE + QQ K Sbjct: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRK 1992 Query: 2448 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 + EK +A E RL+ E+ Q ++ + +A + ++ + ++ ++ Sbjct: 1993 EMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKR 2050 Query: 2508 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2566 + ++ AER A + + ++ Q + AEE G + E A + V+ Sbjct: 2051 HEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVS 2105 >gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] Length = 3639 Score = 357 bits (917), Expect = 1e-97 Identities = 658/2883 (22%), Positives = 1149/2883 (39%), Gaps = 414/2883 (14%) Query: 179 RVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFH 235 ++Q+KTFTKW+N Q I +LY +L DG +L+ LLE++SG++LP +GR+R H Sbjct: 19 QMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPPPSRGRLRVH 78 Query: 236 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSEDM 295 L+N AL +LR + V + I ++I DG+ L LGLIW IIL FQIS I + + Sbjct: 79 FLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHISLDKEEFGA 137 Query: 296 TA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 350 +A KE LL+W QR Y + +F+ SW DG FNA+IH H+P L+D + Sbjct: 138 SAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDLLDYGSLRPD 197 Query: 351 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVR 410 L NL AF VAE++LG+ +LLDPEDV QPDE+SI+TYVS Y R+ Q R Sbjct: 198 RPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSRLHQGQTVQR 257 Query: 411 --------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 462 E +L +Y +LV LL+W+ E R FP S + L + F F+ Sbjct: 258 RLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQLLAAFTIFR 317 Query: 463 EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGKLHVAILERE 518 E P + + ++ + L+ A+QA Q + P G ++ + W L A R Sbjct: 318 TQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAGLEWAEAARS 376 Query: 519 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAAGKVPQRAGE 574 + L+ +L+ L+ + + Q +A L E L A+ +L L QR G Sbjct: 377 QALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATVEAAVQRLGM 436 Query: 575 VERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVA 634 +E + + + L L+ ++ + RR + V +R + RL + Sbjct: 437 LEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ---RLLQHLQ 488 Query: 635 APATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLG 693 QVA + + S+ + E L LQ+ Q + E +EAQ+ Sbjct: 489 GQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQRHDLLEAQVS 548 Query: 694 SHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLE 753 +H + + A+++ + ++ A L +L L+ + +A L Sbjct: 549 AHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRARRALLEQTL 604 Query: 754 SLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQ 813 F+ +E WL E + + + + + AL E+ + +L Sbjct: 605 QRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHRHQAVCVDLV 664 Query: 814 NAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEG 873 G L P +P A+Q W + A L+ Q+F+D EA Sbjct: 665 RRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQYFADAAEAAS 724 Query: 874 QLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKGHLSGLAKRA 925 L++ + +L R SC D++A T RLE +L+ E +L E S A Sbjct: 725 WLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGRAASARASLF 783 Query: 926 KAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSE 985 L P P +R P + + GD ++ PA+P Sbjct: 784 TVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD----------- 824 Query: 986 AAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS 1045 P P + Q+ +++ +AL L + +L + S ++QL Sbjct: 825 ---PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSSCGELQLWLE 878 Query: 1046 WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---REYGSCSHHY 1102 + ++P Q L ++L Y+ FL G E AE + Y S Sbjct: 879 KQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQRYPGNSTQI 936 Query: 1103 QQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQLEACE---- 1137 Q+ + L Q G E + ++ + +L+D+ LQLEA + Sbjct: 937 QRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQLEALQPGSS 996 Query: 1138 TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPA- 1196 T H L+L K E +R+ Q +VE EP A Sbjct: 997 EDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE--------------------EPGYAE 1034 Query: 1197 APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1256 + L+ ++E G L+QV+ E+V + Q E QA Sbjct: 1035 SQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARRQ-AETQARQ 1070 Query: 1257 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1316 + L E + + ++AQ +++ + D +RL + H + E+ W+E Sbjct: 1071 SFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDLLEEIHLWQE 1121 Query: 1317 RVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1372 R+ QL + Q + A +E L LG+Q + + + WLQ+ Q+ + Sbjct: 1122 RLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEGLELQKFGR- 1180 Query: 1373 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1432 + QA L ++ GE V E +Q+ +++ L T + E Sbjct: 1181 ----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLLSTLGPRAEA 1231 Query: 1433 VASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489 + + +K VQS + +V ++ ++ ++ L + Q + + +L+ E ++ +AE Sbjct: 1232 LRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQLQEWKQDVAE 1290 Query: 1490 -QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQEEVVRREEA 1544 Q EE+ +A E A Q + H A+++ A R E Q++ E++ R Sbjct: 1291 LMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPC 1350 Query: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604 + IQ LQ LR EA + + + +++ Q E RQ Sbjct: 1351 G------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG------------QQEQLLRQ 1392 Query: 1605 RGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAEVELASRVKA 1660 A+ +L+ L + +E Q ++ + ++ +Q++ ES+ K A +A + A Sbjct: 1393 LQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAALASMAHGMAA 1452 Query: 1661 EAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRSAEAELQSKR 1719 E Q+ L+ LE LQ A R L+ QA VE + ++ AE Sbjct: 1453 SPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSP 1510 Query: 1720 ASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAERAREEAEREL 1768 S+ E L R +E V V + + +R A +A+ E+ + Sbjct: 1511 TSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE 1570 Query: 1769 ERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQREL 1826 W +A EA LQ QQ L +E E EE R ++A R + Sbjct: 1571 GHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGRDEAATLRLI 1630 Query: 1827 AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1886 + + ++ ++ + L + + EQ ++ L E+L LQ AA + Sbjct: 1631 NKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQELAAT---R 1687 Query: 1887 RQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAGRFR---EL 1936 +ELE E + +++ LAS+ +A + S E + L + +F+ E+ Sbjct: 1688 DRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVEM 1747 Query: 1937 AEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEATRLKTEAEIA 1992 + L E+ +R + RQR + A L E A G A R TE + Sbjct: 1748 GSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR-DTETTLR 1806 Query: 1993 LKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERLAQLRKASDS 2041 + E E+ L + A LE Q H+ E +L +L + + Sbjct: 1807 VHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQELLETAGR 1866 Query: 2042 ELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED----TLR 2097 + G ++QR+Q + A+ + + E L R R+ D R Sbjct: 1867 VQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDYASWAAR 1926 Query: 2098 SKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEEAARQRKAAL 2145 ++ ++E + Q + L AE E R + ++ Q A A K Sbjct: 1927 VRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGTPTKEVQ 1986 Query: 2146 EEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKAHAFAVQQKE 2199 EE+ L+ + ++ R +ER + E QL L + + + A E A+ Sbjct: 1987 EELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTSALGSSV 2046 Query: 2200 QELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE-----------REAAQSR 2245 +E++Q +++ + L L + + A R + RV+ +E A+SR Sbjct: 2047 EEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVKELAESR 2106 Query: 2246 RQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEM 2304 A L S + A QA QA A++L++ R + L + QA +AE+ Sbjct: 2107 GHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLLKHQAFEAEV 2163 Query: 2305 EKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLEETDHQKNLL 2342 + H+ K E L Q +V Q L LR L+ +E + ++N L Sbjct: 2164 QAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELEDRRNFL 2223 Query: 2343 DEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI---------EAENRALIL 2393 E LQR+ + EA Q +V+ + + +E +L+ R+ + A I Sbjct: 2224 -EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIR 2280 Query: 2394 RDKDNTQRFLQEEAEKMK------------------------QVAEEAARLSVAAQEAAR 2429 D + + + E++K Q E A + V ++E Sbjct: 2281 SISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDN 2340 Query: 2430 LRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQK----ELAQ 2477 + + +E A +AL +++L++ + +E ++A+ E L+++ + + Sbjct: 2341 VTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSP 2400 Query: 2478 EQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEAERLKLRVAE 2528 E A L+ ++++A+ QL Q + L+A Q Q E+ A+RL+ A+ Sbjct: 2401 EAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLR---AQ 2457 Query: 2529 MSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHD-AERLR 2586 M + A R+ +A+R ++ +E +L + + ++L ++ Q + H + +R Sbjct: 2458 MDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTAGHPFSSDIR 2513 Query: 2587 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEKDSLLQRERF 2645 + +A LE+E L + QE LQ QAL+ Q FLS S+ + ER+ Sbjct: 2514 QVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS---SVEKMERW 2556 Query: 2646 I-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2704 + +E + + D +A + L + + + +E + + ++++E R H+ G Sbjct: 2557 LCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARGLHQG--GHP 2613 Query: 2705 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2764 Q L + + ++E L + R R +L+ L Q +A L S+EV A+ + + Sbjct: 2614 EAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AAWLREKNLVA 2670 Query: 2765 NGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ-----GHTTVDEL 2819 LD A+ L+++ + Q +A + +ELQR Q GH + + Sbjct: 2671 LEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAI 2723 Query: 2820 ARR 2822 R Sbjct: 2724 QER 2726 Score = 179 bits (454), Expect = 6e-44 Identities = 467/2118 (22%), Positives = 814/2118 (38%), Gaps = 368/2118 (17%) Query: 562 LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 621 L A + ++ E++ ++ ++ + + ++L HPQ + + + L + Sbjct: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576 Query: 622 RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 681 R AQ Q+V + D + +L WVEE + V ++ Sbjct: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619 Query: 682 GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 740 G D + + H+ L + + + + +E L+ P R RL Q Sbjct: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679 Query: 741 LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 796 L + R R LE LH F+ A WL ++K+ + G + + ++ Sbjct: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739 Query: 797 ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 856 ++E+ +++ + + LL H A P V Q LQT WS + +L Sbjct: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791 Query: 857 ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 916 +A G ALR D T+ DLL+ +E+ Sbjct: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825 Query: 917 HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 976 P + A + G + ++ H+G E +LVG + Sbjct: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858 Query: 977 KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 1036 ++L ++G V +C P +A R +A QA L ++ L + L Sbjct: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910 Query: 1037 RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 1091 R +R SW+ + L+ EE Q S L+L +LR +A Sbjct: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960 Query: 1092 EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 1151 E+ + + QQ L + +E Q + L+D R Q+ R RL+ ++ Sbjct: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017 Query: 1152 P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1192 REC + I Q+ + LG V L+A+ +K AL E Sbjct: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077 Query: 1193 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1249 + P +R L + L + +V+ L+ L L+ TQ A E+ ++A +QL Sbjct: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137 Query: 1250 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1309 KE P L + K LK +AE Q A + + + GE L + R Sbjct: 2138 KEP-VPPGDLRD--KLKPLLKHQAFEAEVQ-----AHEEVMTSVAKKGEALLAQSHPRAG 2189 Query: 1310 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA------ 1363 EV +R+ L + W+ + +R +ELE R + + D AW+Q+ Sbjct: 2190 EVS---QRLQGLRKHWEDLRQAMALRGQELEDR-RNFLEFLQRVDLAEAWIQEKEVKMNV 2245 Query: 1364 -------------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE-CQRFA 1409 RRR + + D+ L+ R E+V+ CQR Sbjct: 2246 GDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQR-R 2304 Query: 1410 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469 Q N + L+ Y+ QLE + IQE L + Sbjct: 2305 SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD-----CGK 2359 Query: 1470 YIKFISETLRRMEEEER----LAEQQRAEERE--RLAE--VEAA---LEKQRQLAEAHAQ 1518 ++ + LR+ EE ER + Q + ERE RL + EAA +Q+++AE+ Q Sbjct: 2360 DLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ 2419 Query: 1519 AKAQAER---------EAKELQQRMQEEVV--RREEAAVDAQQQKRSIQEELQQLRQSSE 1567 +++A++ +A++LQ +QE +V +R A +D RS E + L + E Sbjct: 2420 LRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQE 2479 Query: 1568 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627 + + + ++ +R ++ + + G E EL +L +E + Q + Sbjct: 2480 CKAELDS-WTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQ 2538 Query: 1628 QAQE------EAERLRRQVQDESQ-------------------RKRQAEVEL---ASRVK 1659 QA E E++ R + + + + E +L A ++ Sbjct: 2539 QALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKIS 2598 Query: 1660 AEAEAAR--------EKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETAQR 1709 A AR E Q AL + + L+ E R+ R+ +E RQ+Q L+ +Q Sbjct: 2599 ALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQE 2658 Query: 1710 SAEAELQSKRASFAEK----TAQLERSLQEEHVAVAQLREEAERRAQQQAEAER------ 1759 A A L+ K E+ TA L LQ++ A+L ++ + Q E +R Sbjct: 2659 VA-AWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717 Query: 1760 -AREEAERELER----WQ-------------LKANEALRLRLQAEEVAQQKSLAQAE--- 1798 A E + LE W KA EALRLR EE+ + E Sbjct: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777 Query: 1799 ---------------AEKQKEEAEREARRRGKA---EEQA-VRQRELAEQELEKQ----- 1834 +++ E A + R+ +A + QA VR+ Q++E+Q Sbjct: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLL 2837 Query: 1835 ---RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-ELARLQREAAAAT------ 1884 + L E ++R A E + L+ + E+ + E+ LA Q + + Sbjct: 2838 QRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQ 2897 Query: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1944 ++ Q LE+E++ A V+L + + + + + R++ L EAAR R Sbjct: 2898 EQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRR 2957 Query: 1945 ALAEEAKRQRQLAEE--DAARQRAEAERVL-AEKLAAIGEATR-LKTEAEIALKEKEAEN 2000 L ++A+ +Q E +A AE VL +E + EAT+ L E ++ EA + Sbjct: 2958 LLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017 Query: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIE---ERLAQLRKASDSELERQKGLVEDTLRQR 2057 R+ RL + A R ++ + A ++ E A+L + +++ R GL E Q Sbjct: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEA---RGHGLQEQL--QL 3072 Query: 2058 RQVEEEILALKASFE-KAAAGKAE---LELELGRIRSNAEDTLRSKEQA--ELEAARQRQ 2111 Q+E E L L A KAA +++ +LE ++ D R + Q+ + + R+ Sbjct: 3073 HQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRK 3132 Query: 2112 LAAEEERRRREAEERVQKSLAAEEEAARQR-KAALEEVER-LKAKVEEARRLRE-RAEQE 2168 LA ER +Q A R R +AA E +++ +KA+ E E + Q+ Sbjct: 3133 LAGTLERGAPRRYPHIQ--------AQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184 Query: 2169 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228 +A +LQ + ++ E+ H+ + + Q+ + L++E + E E AR E Sbjct: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAM-----EKEVARLQTE 3239 Query: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288 ++ ++ Q E L+ A+E+ Q AQA L + E A Sbjct: 3240 ACRLGQLHPAAPGGLAKVQ-EAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLA----- 3293 Query: 2289 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2348 A RQ+ A+ E+ + AEQ L Q ++ QE+ RLQ ++ + L + Sbjct: 3294 --WAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351 Query: 2349 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2408 + AE TE +EL ++EE L+ + AE+ L + Sbjct: 3352 MSAEVTECL-------QELEGRLQELEEAWALRWQRCAESWGL----------------Q 3388 Query: 2409 KMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRAL-AEKMLKEKMQAVQEATRL 2462 K++Q E+A +A E L+ +++ +L R EK+L + + + + Sbjct: 3389 KLRQRLEQAEAW-LACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT 3447 Query: 2463 KAEAELLQQQKELAQEQA 2480 + E ELL Q +EL +A Sbjct: 3448 EMEQELLLQPQELKPGRA 3465 Score = 168 bits (426), Expect = 1e-40 Identities = 525/2412 (21%), Positives = 903/2412 (37%), Gaps = 375/2412 (15%) Query: 639 QVAQVTLQSVQRRPELE--DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 696 QV + Q +R+ E + S L+ Q LL W E Q ++ E VD+ S + L H+ Sbjct: 1051 QVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110 Query: 697 GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA-KLLNSSKARLRSL--- 752 L +EE ER + + Q P A DC ++ ++L L+ L Sbjct: 1111 DL---LEEIHLWQERLQQLDAQSQPM---AALDCPDSQEVPNTLRVLGQQGQELKVLWEQ 1164 Query: 753 ---------------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA 797 + F A WL+ + +G D + + + +E Sbjct: 1165 RQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVREALSLLQQHRE---- 1217 Query: 798 LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE 857 R L + + L+ G++L++ HPA TV ++Q QW+ +L E ++ Sbjct: 1218 FGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWT---RLQGRSEQRRRQ 1274 Query: 858 NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH 917 A Q + ++ +L + E + + S + L+ + + +L + H Sbjct: 1275 LLASLQL-QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRH 1333 Query: 918 LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 977 + L + + ++ +P L + + ++T +GDE Q G Q + Sbjct: 1334 VEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT-ERGDELQQAGQ-QEQLLR 1391 Query: 978 VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 1037 L + + Q+ + + RL+ +HQ L + L M +L + Sbjct: 1392 QLQDAKEQLEQLEGALQSSETGQDLRSS-QRLQKRHQQLESESRTLAAKMAALASMAHGM 1450 Query: 1038 RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 1097 I + R L+ + A+ L+L QA + Q E +AE Sbjct: 1451 AASPAILEETQKHLRRLELLQGHLAIRGLQL--QASVELHQFCHLSNMELSWVAEHMPHG 1508 Query: 1098 CSHHYQQLL---QSLEQGAQE--------ESRCQRCISELKDIRLQ--------LEACET 1138 Y + L QSL + +E + + QR +S + + +E C+ Sbjct: 1509 SPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQE 1568 Query: 1139 RTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1198 H L E +C Q+ Q+ +V L V + V + A Sbjct: 1569 LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEE---KRPLVSSRDYGRDEAA 1625 Query: 1199 TLRSELELTLGKLEQVRSLSAIY---LEKLKTISLVIRGTQGAEEVLRAHE---EQLKEA 1252 TLR + K + ++ AIY +E+L + + G + E+ E EQL+ Sbjct: 1626 TLR-----LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL 1680 Query: 1253 QAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE------RLQQRHG 1305 Q + AT ELE T + LR +AE Q + + +G + +GE L + Sbjct: 1681 QELAATRDRELEGTLRLHEFLR-EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739 Query: 1306 ERDVEVERWRERVA-------QLLER------------------WQAVLAQTDVRQRELE 1340 + +VE +RVA LLER W + T R L Sbjct: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR 1799 Query: 1341 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP---LADSQAVREQLRQEQALLEEIER 1397 LR +R+ + L + QE+ ++P D + QLR Q L E+ Sbjct: 1800 DTETTLRVHRDLLEVL-------TQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVG 1852 Query: 1398 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQ------------LEPVASPAKKPKVQSG 1445 +++E A + + V + Q +E + ++ ++ + Sbjct: 1853 TERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR 1912 Query: 1446 SESVIQEYV--------DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1497 + +++Y DL+ S +S +K + R E E R Q+A + Sbjct: 1913 FRTAVRDYASWAARVRQDLQVEESSQEP-SSGPLKLSAHQWLRAELEAREKLWQQATQLG 1971 Query: 1498 RLAEVEAAL------EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE----EAAVD 1547 + A + A E+ R L + Q R+ + LQ QE++ RE E + Sbjct: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031 Query: 1548 AQQQKR------SIQEELQQLRQSSEAEIQAKARQ--AEAAERSRLRIEEEIRV---VRL 1596 AQ+ S EE++QL + E ++ Q EAA R RL+ RV + + Sbjct: 2032 AQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPI 2091 Query: 1597 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE------AERLRRQVQDESQRKRQA 1650 L+ R + AE AL A A + Q E A++L+ V R + Sbjct: 2092 LLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLK 2151 Query: 1651 EVELASRVKAEAEAAREKQRALQALEELRL-----QAEEAERRLR--QAEVERARQVQVA 1703 + +AE +A E ++ E L +A E +RL+ + E RQ Sbjct: 2152 PLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAM-- 2209 Query: 1704 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA--VAQLREEAERRAQQQAEAERAR 1761 A R E E + F ++ E +QE+ V V L ++ E Q + R Sbjct: 2210 ---ALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFR 2266 Query: 1762 -EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE------REARRRG 1814 A + +++ L L+L+ + + K + Q ++ A R ++ Sbjct: 2267 GNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLE 2326 Query: 1815 KAEEQAVRQREL---AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQRQ 1867 A E V REL ++ EK+ + + L + Q L+R E E+ + Q + Sbjct: 2327 GALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVE 2386 Query: 1868 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1927 LE E+ RL + + A + + E+A E L S+A+ E+ ++ Q+L+ Sbjct: 2387 SLEREVGRLCQRSPEAAHGLRHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQ 2441 Query: 1928 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1987 A +EL A RLRA + + R E A R E + AE + + ++ Sbjct: 2442 A---MLQELLVSAQRLRAQMDTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARS 2496 Query: 1988 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQ 2046 + L + +R++ + LE +H+ +++ L QL +S ++ER Sbjct: 2497 TGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERW 2556 Query: 2047 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 2106 ED+L + + + ++ K + +LE++ G+I S E T R Q Sbjct: 2557 LCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPE 2614 Query: 2107 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2166 A+ + R+EA R + E RQ +A L++ + + A + E + L E Sbjct: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEE 2673 Query: 2167 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2226 + AQ Q+ QAE A Q+ ++E Q+ LQ + ++ E Sbjct: 2674 GLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGAL 2733 Query: 2227 AEEAEE------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRK 2277 E ++ A++Q EA + RR +EE E + E + +A QA E L Sbjct: 2734 WGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGT 2793 Query: 2278 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD- 2336 + E EAA +A QA QA E H A+ Q ++ Q +LR L+E Sbjct: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRT 2852 Query: 2337 --HQKNLL-------DEELQRLKAEATEAA---------------RQRSQVEEELFS--- 2369 ++LL DEE+ ++ + AA Q +E E+ S Sbjct: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEA 2912 Query: 2370 ------------------------VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2405 RVQ E + R EA R L+L+ Q+FL E Sbjct: 2913 LTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTE 2972 Query: 2406 EAEKMKQVAEEAARLS------VAAQEAARLRQLAE------------EDLAQQRALAEK 2447 E +AE L A A LR+L E L Q AL E Sbjct: 2973 LLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLES 3032 Query: 2448 -------MLKEKMQAVQEA-----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2495 + ++QAV+EA R +A LQ+Q +L Q + L D + Sbjct: 3033 RKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAAT 3092 Query: 2496 EETQGFQRTLEAER---------QRQLEMSAEAERLKLR-----------------VAEM 2529 E+Q + + LE + +++++ +A+ LR A+ Sbjct: 3093 AESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQR 3152 Query: 2530 SRAQARAEEDAQRFRKQAEEI--GEKLHRTELAT-------QEKVTL------------V 2568 SR +A E Q + + E + ++H + A QEK L V Sbjct: 3153 SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSV 3212 Query: 2569 QTLEIQRQQSDHDAERLREAIAELEREK--------------EKLQQEAKLLQLKSEE-- 2612 +TL+ Q ++ + + E + + +A L+ E K+Q+ LQ K++E Sbjct: 3213 RTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERG 3272 Query: 2613 ---MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2669 Q Q L Q L ++ E+ L E E + A EQL Q++R Sbjct: 3273 QWLAQAAQGHAFLGRCQEL-LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR- 3329 Query: 2670 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2727 E + Q Q + QE Q+LV + + E E ++ + LQ+LE+ + + AE Sbjct: 3330 ECRLQAQDLRQEGQQLV---DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWG 3386 Query: 2728 NQRLREQLQLLE 2739 Q+LR++L+ E Sbjct: 3387 LQKLRQRLEQAE 3398 Score = 139 bits (351), Expect = 5e-32 Identities = 451/2066 (21%), Positives = 800/2066 (38%), Gaps = 334/2066 (16%) Query: 1032 AWQSLRRDVQLIRS-WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 1090 A ++R +Q I++ W+ R+ + +RQ L SL+L Q + +D + + E LM Sbjct: 1246 AAHTVREQLQSIQAQWTRLQGRS--EQRRRQLLASLQL--QEWKQDVAELMQWMEEKGLM 1301 Query: 1091 AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL---EACETRTVH-RLRL 1146 A E + Q L+ E E +R + L+ + +L C + RL+ Sbjct: 1302 AAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQG 1361 Query: 1147 PLDKEPA--RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1204 K A R+ +R E Q+A + E L + + + E++ + S LRS Sbjct: 1362 LRSKWEALNRKMTERGDELQQA-GQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420 Query: 1205 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1264 L + +Q+ S S K+ ++ + G + +L ++ L+ + + L Sbjct: 1421 RLQK-RHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHL----- 1474 Query: 1265 TKASLKKLRAQAEAQQPTFDALRDE--------------------LRGAQEVGERLQQRH 1304 +++ L+ QA + F L + L GAQ L ++H Sbjct: 1475 ---AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQS----LHRKH 1527 Query: 1305 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1364 E VEV+ + +V ++L +++ A + + + + ++L G W + R Sbjct: 1528 KELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE---------GHWAELER 1578 Query: 1365 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK------------QY 1412 + A +Q +++ + +Q L+ E G VEE + + Sbjct: 1579 ACE--------ARAQCLQQAVTFQQYFLDVSELEGW-VEEKRPLVSSRDYGRDEAATLRL 1629 Query: 1413 INAIKDYELQLVTYKAQLEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1469 IN + + +L Y + +E + A+ P+V + V+QE LR L L + Sbjct: 1630 INKHQALQEELAIYWSSMEELDQTAQTLTGPEVPE-QQRVVQER--LREQLRALQELAAT 1686 Query: 1470 YIKFISETLRRME---EEERL-----AEQQRAEERERLAE-VEAALEKQRQLAEAHAQAK 1520 + + TLR E E E L +++Q A+ E L E E AL + A+ Q + Sbjct: 1687 RDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746 Query: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1580 ++R A + + E ++ R +A +Q+ Q++LQ QA+ Sbjct: 1747 MGSQRVAA--CRLLAESLLERGHSAGPMVRQR---QQDLQTAWSELWELTQARGHALRDT 1801 Query: 1581 ERSRLRIEEEIRVVRLQLEA--------TERQRGGAEGELQALRARAEEAEAQKRQAQEE 1632 E + LR+ ++ V Q++ R G E +L++ + E +RQ QE Sbjct: 1802 ETT-LRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860 Query: 1633 AERLRR-----------QVQDESQRKRQAEVELASRV---KAEAEAAREKQRALQALEEL 1678 E R VQ Q QA L R+ +A+ E AR R A+ + Sbjct: 1861 LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920 Query: 1679 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL----- 1733 A + L+ E + +A + AEL+++ + + T +++L Sbjct: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980 Query: 1734 -----QEEHVAVAQLREEAER---RAQQQAEAERAREEAERELERWQ-LKANEALRLRLQ 1784 QEE A+ R++ + R Q++ +AE+ + RE R + + A + + L+ Sbjct: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040 Query: 1785 A-----EEVAQ-----QKSLAQAEAEKQKEEAEREA-----RRRGKAEEQAVRQRELAEQ 1829 A EEV Q + L A+ +KE A RE R R + + QR + + Sbjct: 2041 ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100 Query: 1830 ELEKQR------QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-- 1881 EL + R L + Q ++ I+ A+ + L ++L L + A Sbjct: 2101 ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160 Query: 1882 AATQKRQELEAELAKVRAEMEVLLA-SKARAEEESRSTSEKSKQ---RLEAEAGRFRELA 1937 A Q +E+ +AK + E LLA S RA E S+ K +A A R +EL Sbjct: 2161 AEVQAHEEVMTSVAK---KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217 Query: 1938 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA---------------AIGEA 1982 + L L + + E++ + + L L +G+A Sbjct: 2218 DRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDA 2277 Query: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR------------------LEEQAAQH 2024 +++ ++++L+ K + E ++ + + + R LE Sbjct: 2278 C-IRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336 Query: 2025 KADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELE 2082 + D + Q ++A L+ K L V+ LR+ ++E E+ ++A E LE Sbjct: 2337 ELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES-------LE 2389 Query: 2083 LELGRIRSNAEDT---LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE--- 2136 E+GR+ + + LR ++Q E+ Q + A++ R +A + QK A +E Sbjct: 2390 REVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV 2449 Query: 2137 AARQRKAALEEVERLKAKVEEARRLRE----RAEQES-ARQLQLAQEAAQKRLQAEEKAH 2191 +A++ +A ++ ++ VE R L E +AE +S + LA+ Q+ L A H Sbjct: 2450 SAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTA---GH 2506 Query: 2192 AF--------------------AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231 F A Q+ + +LQQ L+ + + + E + A Sbjct: 2507 PFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLAS 2566 Query: 2232 EA------------------RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2273 E E +A + A L Q +AQ+ A + A Sbjct: 2567 EGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQS-ALGRCQAM 2625 Query: 2274 KLRKEA--EQEAARRAQAE-----QAALRQKQAADAEM-EKHKKFAEQTLRQKAQVEQEL 2325 LRKEA Q RR + E QA L+ Q A + EK+ E+ L A + +L Sbjct: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685 Query: 2326 T---TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2381 + +L+ + HQ+ L E QRL A+ + EEL ++ ++++ S+ K Sbjct: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKV 2745 Query: 2382 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2441 A+++ AL LR EE E + E R Q + +L L Q Sbjct: 2746 AKLQKACEALRLRRS-------MEELENWLEPIEVELRAPTVGQALPGVGEL----LGTQ 2794 Query: 2442 RALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2498 R L + K+ QA + +A E L Q E EQARRL + + + + L E Sbjct: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVE---EQARRLLQRFKSLREPLQERR 2851 Query: 2499 QGFQRT---LEAERQRQLEMSAEAERLKLRVAE---MSRAQARAEEDAQRFRKQAEEIGE 2552 + L+ R EM+ E+L L A+ S + R ++ + + E Sbjct: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911 Query: 2553 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2612 L R L T K+ Q A + + +LE+ L+ EA +L ++ Sbjct: 2912 ALTRVVLGTGYKLV---------QAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQ 2962 Query: 2613 MQTVQQ--EQLLQETQALQQS--FLSEKD---------SLLQR----ERFIEQEKAKLEQ 2655 Q QQ +LL+ L + L +D +LL+R +R +E ++E+ Sbjct: 2963 AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIER 3022 Query: 2656 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2715 L Q + E + Q++ R+ + A R H +E ++ Q E + L Sbjct: 3023 LQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLL 3082 Query: 2716 QRRQQEELLAEENQRLREQLQ---LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2772 + E+Q + L+ +LEE+ A + + ++V A + L L+ Sbjct: 3083 DAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG---TLER 3139 Query: 2773 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2832 A P R + + +RL +A E L + H+ A LQGR Sbjct: 3140 GAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAE-------LQGR 3192 Query: 2833 SSIAGLLLKATN--EKLSVYAALQRQ 2856 L+K + LS LQ+Q Sbjct: 3193 MQEKTALMKGEDGGHSLSSVRTLQQQ 3218 Score = 67.0 bits (162), Expect = 4e-10 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%) Query: 481 QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 535 +SLE V + P H L +V + W +L +R + L + + + LQ ++ Sbjct: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444 Query: 536 TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 595 +L + A Q++ + A + A ++ + E + +LD I L + Q Sbjct: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500 Query: 596 LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 652 L HP + + + L + L ++ E+ L+L+ + Q+ L SV++ Sbjct: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554 Query: 653 EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 705 EDS L D LA +E + EW +++ + + A + RGLHQ Sbjct: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612 Query: 706 RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 763 P + A C L + A + + + RL L L +F+ + Sbjct: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657 Query: 764 KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 823 + WL EK + D + A+ + EL+ + +ELQ G RLL+ Sbjct: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716 Query: 824 HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 883 HPA ++ L W L++N+ ++ +LQK EALR Sbjct: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756 Query: 884 RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 938 + S + LE+ L+ + E Q G L G + +A V K R A Sbjct: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809 Query: 939 PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 998 + G Q + V +G C L + ++L S Sbjct: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843 Query: 999 NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 1058 + QE T LEA+ +L + D +AW + + + + + +E Sbjct: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898 Query: 1059 QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 1118 Q Q L S ++A R G + A E + ++ + L A Sbjct: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958 Query: 1119 CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1174 + E + +L + R + LD E + E Q + + +A + ++E Sbjct: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017 Query: 1175 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1234 + RL A L +P +P + L +L+ VR A L + + RG Sbjct: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063 Query: 1235 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1291 G +E L+ H+ + +E + A L AT S + + + FDA R E++ Sbjct: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121 Query: 1292 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1343 +++ L++ R ++ R R+ ER QA+ A+T E Sbjct: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176 Query: 1344 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1399 ++ ++++A L R QE+ M D +VR +Q + L E+E Sbjct: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230 Query: 1400 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1459 ++V Q A + QL P A+P KVQ + + +Q R Sbjct: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273 Query: 1460 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1519 + ++ E L +E + LA + E E +A E L + +L + + Sbjct: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331 Query: 1520 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1571 + QA+ +E QQ + E Q+ + +Q EE LR AE ++ Sbjct: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391 Query: 1572 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1627 + QAEA E L+ + V ++L Q +L+ L A EE AQ + Sbjct: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445 Query: 1628 QAQEEAERL 1636 + + E E L Sbjct: 3446 KTEMEQELL 3454 Score = 53.5 bits (127), Expect = 5e-06 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%) Query: 415 QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474 QL+ + LLL W+ A E + + E +++L +F F+ KE Sbjct: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122 Query: 475 RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 530 +Y + L G ++ G + P +E W +L AI R + L + E Sbjct: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178 Query: 531 LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 587 V Q A + ++ + AL++ + L + + Q+ +ER+L+ + + Sbjct: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234 Query: 588 LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 647 L + L HP +V A + A A + Q Q+ Sbjct: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278 Query: 648 VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 707 Q + L Q+LLAW +E Q E D+ E LG H L Q I E R Sbjct: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333 Query: 708 KIERARSDEGQL 719 + + R + QL Sbjct: 3334 QAQDLRQEGQQL 3345 >gi|148746195 trichohyalin [Homo sapiens] Length = 1943 Score = 352 bits (902), Expect = 6e-96 Identities = 484/1900 (25%), Positives = 851/1900 (44%), Gaps = 251/1900 (13%) Query: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134 R +D F P DR + E E G Q Q QE+ R EL + Q E Sbjct: 114 RQEEDQRRFEPRDRQL-EEEPG----------QRRRQKRQEQER------ELAEGEEQSE 156 Query: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194 E R R R D+E R+ Q E+++ +AE E L S + + P+ Sbjct: 157 KQE-RLEQRDRQRRDEELWRQ-RQEWQEREERRAEEEQL------QSCKGHETEEFPDEE 208 Query: 1195 PAAPTLRSELELTLGKLEQVRS-----LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1249 R LEL E+ + ++ E+ + + + E VLR EE+L Sbjct: 209 QL--RRRELLELRRKGREEKQQQRRERQDRVFQEEEE------KEWRKRETVLRKEEEKL 260 Query: 1250 KEAQAVPATLPELEATKASLKKL-RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1308 +E + P EL+ + L+KL R + ++ + + LR Q++ + ++ E+ Sbjct: 261 QEEE--PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318 Query: 1309 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1368 E +ER Q ER + L + +RE +QL R+ R L ++ RR Q+ Sbjct: 319 EERREQQERREQQEERREQQLRREQEERRE-QQLRREQEEERRE-QQLRREQEEERREQQ 376 Query: 1369 QIQAMPLADSQAVR--EQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYELQLV 1424 + L Q +R +QLR+EQ L E + R + E Q +Q + ++ E Sbjct: 377 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE---- 432 Query: 1425 TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR---- 1480 ++ + E + + Q ++ + H E Q +K E RR Sbjct: 433 RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE---RRKQQLKRDQEEERRERWL 489 Query: 1481 -MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAEREAKELQQRMQEEV 1538 +EEEER +Q+R E++ R + E ++ +RQ E Q + ++E++ + Q+ +E++ Sbjct: 490 KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549 Query: 1539 VRREEAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-VRL 1596 ++REE +KR QE +Q L++ E ++ E + RL+ E+E R+ RL Sbjct: 550 LKREE-------EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602 Query: 1597 QLEATERQRGGAEGELQALRARAEEAEAQKRQ----AQEEAERLRRQVQDESQRKRQAEV 1652 + E ER + E + R + EE E ++RQ ++E+ ER ++Q++ E Q +R+ Sbjct: 603 KREEVERLE---QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE--- 656 Query: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ-VQVALETAQRSA 1711 R+K E E R +QR + EE E E+ L + E E+AR+ ++ + Q Sbjct: 657 ---QRLKREEEEERLEQRLKREHEE-----ERREQELAEEEQEQARERIKSRIPKWQWQL 708 Query: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-R 1770 E+E ++++ + + E + + + R E+E + Q++ A R ++E E+ + Sbjct: 709 ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768 Query: 1771 WQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQK--------EEAEREARRRGK---- 1815 WQ +A E R RL A +++ Q AE+++ EE E+E RRR + Sbjct: 769 WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828 Query: 1816 ------AEEQAVRQRELAEQELEKQRQLAEGTAQQ-----------RLAAEQELIRLR-- 1856 EE+ +++RE A+Q E++ L E ++ R E+E R R Sbjct: 829 KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888 Query: 1857 -----AETEQGEQQRQLLEEELARLQREAAAATQKRQELE---AELAKVRAEMEVLL--- 1905 A EQ +++QLL+EE LQRE ++RQE E E +++ E E LL Sbjct: 889 LYAKPALQEQLRKEQQLLQEEEEELQRE-EREKRRRQEQERQYREEEQLQQEEEQLLREE 947 Query: 1906 ASKARAEEESRS--TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEE 1959 K R +E R +K +Q+ E G E R + EE + Q++ L EE Sbjct: 948 REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007 Query: 1960 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-- 2017 R+R E ER +K E +L E +EK ER R+ E+E Q+ Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREE----REKRRLQERERQYREEEELQQEEEQL 1063 Query: 2018 --EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 2075 EE+ + + ++E Q RK + + E ++ L E+ ++RRQ E + E+ Sbjct: 1064 LGEERETRRRQELER---QYRKEEELQQEEEQLLREEPEKRRRQERERQCREE---EELQ 1117 Query: 2076 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 2135 + +L E R E + +E+ E++ ++ L E E+RRR+ ER + EE Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR----EE 1173 Query: 2136 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---RLQAE-EKAH 2191 E +Q + L E+ K + E R+ RE E + ++ Q ++ Q+ + Q E EK + Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233 Query: 2192 AF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2248 A V K +E +Q Q E S L + + + E+ E R Q R Q R Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293 Query: 2249 EEAERLKQSAEEQAQAR-AQAQAAAEKLRKEAE-----QEAARRAQAEQAALRQKQAAD- 2301 E E+L++ +++A+ R ++Q + LR+E E QE R+ + E+ L++++ Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353 Query: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361 E+ +KF E+ LR + Q + L +L + ++ L EE Q+L+ + E +Q Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEE-EQRLRRQERERKFLKEE-QQLRCQ--EREQQLR 1409 Query: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEA 2417 Q + F R + ++LS+ + + +R ++ ++FL+EE E+ ++ EE Sbjct: 1410 QDRDRKF--REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467 Query: 2418 ARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQ 2471 L ++ R R+ EE+ +R ++ +E+ QE R L+ E +L +Q Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527 Query: 2472 QKE---LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2528 Q++ L +EQ R QE +Q Q + + ++ + ++QL + +L + Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587 Query: 2529 MSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2586 + R + + ED Q+ R+Q + + R +++ Q L+ + +Q H ER R Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE----QLLQEREEQQLHRQERDR 1643 Query: 2587 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-------QSFLSEKDSL 2639 + LE E + +QE + + + ++EQLLQE + Q + F E+ L Sbjct: 1644 KF---LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700 Query: 2640 LQRER---FIEQE----KAKLEQLFQDEVAKAQQLREEQQRQQQQ----MEQERQRLVAS 2688 ++ER F+++E + +LE+ F++E Q+ +EQ R+Q++ +E+E+ R Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760 Query: 2689 MEEARRRQHE---AEEGVRRKQEELQQLEQQR-----RQQEELLAE-ENQRLR------- 2732 ++ RR++ + EE R++ E QQL Q R++E+L E E Q+LR Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820 Query: 2733 -----EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2787 EQLQL E++ R + A + AT+ E E + R Sbjct: 1821 YRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE--------KSRREEQELWQEEEQKR 1872 Query: 2788 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2827 R+ ++L+E I Q+ Q H V E+ +E H Sbjct: 1873 RQERERKLREEHI---RRQQKEEQRHRQVGEIKSQEGKGH 1909 Score = 346 bits (888), Expect = 3e-94 Identities = 429/1702 (25%), Positives = 734/1702 (43%), Gaps = 233/1702 (13%) Query: 1266 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1325 K SL + R Q E Q+ F+ +L +E G+R +Q+ E++ E+ E+ + Sbjct: 106 KESLLQDRRQEEDQR-RFEPRDRQLE--EEPGQRRRQKRQEQERELAEGEEQSEK----- 157 Query: 1326 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV--RE 1383 Q L Q D RQR E+L RQ + ++E ++ R +EQ+Q+ +++ E Sbjct: 158 QERLEQRD-RQRRDEELWRQRQEWQER--------EERRAEEEQLQSCKGHETEEFPDEE 208 Query: 1384 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1443 QLR+ + L E+ R G + ++ QR +Q Sbjct: 209 QLRRRELL--ELRRKGREEKQQQRRERQ-------------------------------- 234 Query: 1444 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1503 + V QE + E T L + K E +R E + EQ R ER+ L Sbjct: 235 ---DRVFQEEEEKEWRKRE-TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290 Query: 1504 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1561 E+Q+Q Q + + E E +E Q+ +E+ RRE+ +QQ R QEE QQ Sbjct: 291 QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350 Query: 1562 LRQSSE---AEIQAKARQAEAAERSRLRIEEEI-------RVVRLQLEATERQRGGAEGE 1611 LR+ E E Q + Q E +LR E+++ R +L+ E R+ E Sbjct: 351 LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410 Query: 1612 LQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR-EKQ 1669 Q R + E Q R+ QEE ++ Q+ QR ++ + E +K E E R E++ Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470 Query: 1670 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1729 R Q L+ R Q EE R + E E R+ Q E R + E + +R E+ +L Sbjct: 471 RRKQQLK--RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528 Query: 1730 ERSLQEEHVAVAQL-REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1788 ++ L+ E QL RE+ ERR Q E R E ER +R + + E L+ EE Sbjct: 529 QQRLRSEQ----QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584 Query: 1789 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1848 +Q+ L + + E+ ++ +RE R + EE+ ++ + E E E+++QL + Q+ Sbjct: 585 RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644 Query: 1849 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1908 +Q LR E ++ +QR EEE RL+ Q L+ E + R E E+ + Sbjct: 645 QQ----LRREQQERREQRLKREEEEERLE----------QRLKREHEEERREQELAEEEQ 690 Query: 1909 ARAEEESRSTSEKSKQRLEAEAGR------FRELAEEAARLRALAEEAKRQRQ-----LA 1957 +A E +S K + +LE+EA R +E R R EE +R+R+ Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750 Query: 1958 EEDAARQRAEAE-------RVLAEKLAAIGE-----ATRLKTEAEIALKEKEAENERLRR 2005 EE A RQ+ E E + AE+ + G L+ + E L+ +E + R Sbjct: 751 EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810 Query: 2006 LAEDEAFQRRRLEEQAAQHKADI--EERLAQLRKASDSELERQKGLVEDTLRQRR----- 2058 L E+E ++RR + + + + EE Q R+ + E + GL ED R+R Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870 Query: 2059 ------QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 2112 Q+EEE + + A + +L E ++ E+ R + + ++RQ Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930 Query: 2113 AAEEERRRRE----AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2168 EE+ ++ E EER ++ E R+ K ++ E+L + E RR +ER E++ Sbjct: 931 REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER-EKK 989 Query: 2169 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2228 + +L QE Q + EK +++ ++ + Q+E+ +L + R + R + Sbjct: 990 YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049 Query: 2229 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2288 EE +Q E E E R +Q E Q + + Q E+L +E E E RR + Sbjct: 1050 YREEEELQQEEEQLLGE---ERETRRRQELERQYRKEEELQQEEEQLLRE-EPEKRRRQE 1105 Query: 2289 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2344 E+ +++ E E+ +K Q L ++ + E+E+ QL + +K + Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR-RRQ 1164 Query: 2345 ELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2403 EL+R E E ++ Q + EE R + E + + ++ + R RD+D + L Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ-RSDL 1223 Query: 2404 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ-------QRALAEKMLKEKMQ-- 2454 + + E K+ A ++ +E + RQL + L Q L E+ +++ Q Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283 Query: 2455 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QR 2511 Q+ R E E L++++ Q++A+R ++ Q L EE + +R E +R + Sbjct: 1284 RRWQQRDRHFPEEEQLEREE---QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE 1340 Query: 2512 QLEMSAEAERLKLRVAEMSRAQARAE-----------EDAQRFRKQAEEIGEKLHRTELA 2560 + ++ E E LR E R E E+ QR R+Q E +L Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400 Query: 2561 TQEKVTLV----------QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2610 QE+ + + ++ RQ+ D + + ERE++ L++E +L Q + Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460 Query: 2611 EEMQTVQQEQLLQETQALQ-------QSFLSEKDSLLQRER-----------------FI 2646 + + ++EQLLQE + Q + FL E+ L ++ER F+ Sbjct: 1461 RKFR--EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518 Query: 2647 EQE-----KAKLEQLFQDEVAKAQQLREEQQRQ--------QQQMEQERQRLVASMEEAR 2693 E+E + + + Q+E +Q R +Q+RQ ++Q+ QER+ S +E Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578 Query: 2694 RRQHEAEEGVRRKQEE---LQQLEQQRRQ--QEELLAEENQRLREQLQLLEEQHRAALAH 2748 R+ E+ VRR+++E ++ +Q RRQ Q++L E +++ RE QLL+E+ L Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638 Query: 2749 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2808 E + L E + H D R+ Q LQE +R Sbjct: 1639 QER--------DRKFLEEEPQLRRQEREQQLRHDRDRKFRE-EEQLLQEGEEQQLRRQER 1689 Query: 2809 LAQGHTTVDELARREDVRHYLQ 2830 + +L R+E R +LQ Sbjct: 1690 DRKFREEEQQLRRQERERKFLQ 1711 Score = 324 bits (831), Expect = 1e-87 Identities = 430/1733 (24%), Positives = 766/1733 (44%), Gaps = 267/1733 (15%) Query: 1034 QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 1093 Q LRR+ QL R L + L+ E+Q + L Q LR Q R Sbjct: 375 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ--LRREQ-----------QLRR 421 Query: 1094 EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 1153 E Q L + +EE Q+ E ++ RL+ E E R L ++E Sbjct: 422 E------------QQLRREQEEERHEQKHEQERREQRLKREQEERRD----WLKREEETE 465 Query: 1154 RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1213 R +R +Q K E E E+ L L E R E +L + E+ Sbjct: 466 RHEQERRKQQLKRDQEEE-----------RRERWLKLEEEERREQQERREQQLR-REQEE 513 Query: 1214 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1273 R E+ + + +R +E+ LR +E+ +E LE + + R Sbjct: 514 RREQRLKRQEEEERLQQRLR----SEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569 Query: 1274 AQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL-------ER 1324 Q E + + R + R +E ERL+QR +VE ER Q L ER Sbjct: 570 EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629 Query: 1325 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1384 Q +L + +R +QL R+ + RE Q +R +E+ + + ++ Sbjct: 630 RQQLLKSEEQEERRQQQLRREQQERRE---------QRLKREEEE---------ERLEQR 671 Query: 1385 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-----K 1439 L++E EE R E EE Q A++ I + ++ ++ QLE A + + Sbjct: 672 LKREH---EEERREQELAEEEQEQARERIKS------RIPKWQWQLESEADARQSKVYSR 722 Query: 1440 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER- 1498 P+ Q G ++ R SEL + +EEER QQ+ EE+ R Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESEL----------------QWQEEERAHRQQQEEEQRRD 766 Query: 1499 ---LAEVEAALEKQRQLAEAHAQAKAQAERE--AKELQQRMQEEVVRREEAAVDAQQQKR 1553 + E E+ RQ A + Q ER+ A+E QQR ++ + EE ++Q+R Sbjct: 767 FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR-EQRFLPEEEEKEQRRRQRR 825 Query: 1554 SIQEELQQLRQSSEAEIQAKARQ--------AEAAERSRLRIEEEIRVVRLQLEATERQR 1605 ++ELQ L + + + + +A+Q E ER R + + + R QLE ++R Sbjct: 826 EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885 Query: 1606 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1665 L A A E+ +++ QEE E L+R+ +++ +R+ Q Sbjct: 886 ---RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ------------ERQY 930 Query: 1666 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1725 RE+++ Q EE +L EE E+R RQ + R+ + + ++ E + +R EK Sbjct: 931 REEEQLQQ--EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988 Query: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELERWQLKANEALRLRLQ 1784 + E LQ+E + LREE E+R +Q+ E + R ++E ++E E+ + E RL+ + Sbjct: 989 KYREEEELQQEEEQL--LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046 Query: 1785 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1844 + +++ L Q E + E ERE RRR + E Q ++ EL ++E QL ++ Sbjct: 1047 ERQYREEEELQQEEEQLLGE--ERETRRRQELERQYRKEEELQQEE----EQLLREEPEK 1100 Query: 1845 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE---AELAKVRAEM 1901 R E+E + R E E +++ QLL EE + ++RQELE E +V+ E Sbjct: 1101 RRRQERER-QCREEEELQQEEEQLLREEREK---------RRRQELERQYREEEEVQQEE 1150 Query: 1902 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ---RQLAE 1958 E LL R E E R E +Q E E EL +E +L +E +RQ RQ E Sbjct: 1151 EQLL----REEPEKRRRQELERQYREEE-----ELQQEEEQLLREEQEKRRQERERQYRE 1201 Query: 1959 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQ 2013 E+ +++ +R E + + + E E A+++ K ENE+ R+L + + Sbjct: 1202 EEELQRQKRKQRYRDEDQRS-DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL-- 1258 Query: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT-LRQRRQVE-EEILALKASF 2071 R R +Q QH L ++ D E ER++ D + Q+E EE K Sbjct: 1259 RDRQSQQDLQH-------LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311 Query: 2072 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---- 2127 K+ K L E R E + +E+ +L R+ Q +ER R+ EE + Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371 Query: 2128 --QKSLAAEEEAARQRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2183 +K L E+ RQ + L+E ++L+ + E + ++R + + QL+++ ++ Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431 Query: 2184 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR----GEAEAARRAAEEAEEARVQAER 2239 + EE+ Q + QE ++ +E+ L Q R E E + EE + R + +R Sbjct: 1432 FREEEQ------QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485 Query: 2240 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR-AQAEQAALRQKQ 2298 + + +Q+ ER ++ E++ +++ + E+ ++ Q+ R+ Q EQ RQ++ Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545 Query: 2299 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----AT 2354 ++ +KF R++ Q+ QE +L +E D + L +++++R + E Sbjct: 1546 GQQRRQDRDRKF-----REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600 Query: 2355 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414 E +R + +++L R + + + ++ E L ++ ++FL+EE + +Q Sbjct: 1601 EQQLRRQEGQQQL---RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657 Query: 2415 EEAAR--LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2472 E+ R +E +L Q EE +++ K +E+ Q+ R + E + LQ++ Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE----QQLRRQERERKFLQEE 1713 Query: 2473 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2532 ++L +++ R ++EQ+ Q+ +E + RQ + E E+L+ E Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQE--------QLRRQERYRKILEEEQLR---PEREEQ 1762 Query: 2533 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2592 Q R +E ++FR++ E++ ++ +L +QE + + E+LR+ Sbjct: 1763 QLRRQERDRKFREE-EQLRQEREEQQLRSQES-----------DRKFREEEQLRQ----- 1805 Query: 2593 EREKEKL--QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2650 ERE+++L QQ + + E++Q +QEQ L++ + Q E+F QEK Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR---------AEEQFATQEK 1856 Query: 2651 AKLE--QLFQDEVAKAQQLREEQQRQQ----QQMEQERQRLVASMEEARRRQH 2697 ++ E +L+Q+E K +Q RE + R++ QQ E++R R V ++ + H Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGH 1909 Score = 321 bits (822), Expect = 1e-86 Identities = 344/1299 (26%), Positives = 606/1299 (46%), Gaps = 105/1299 (8%) Query: 1518 QAKAQAEREAKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1574 + +A+ + + LQ R QEE RR + ++ + +R Q+ +Q R+ +E E Q++ Sbjct: 98 EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE- 156 Query: 1575 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEA 1633 +Q +R R R +EE+ R + + E +R E +LQ+ + EE +++ + E Sbjct: 157 KQERLEQRDRQRRDEELWRQRQEWQEREERR-AEEEQLQSCKGHETEEFPDEEQLRRREL 215 Query: 1634 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1693 LRR+ ++E Q++R+ E RV E E ++R +E E +L++ E Sbjct: 216 LELRRKGREEKQQQRR---ERQDRVFQEEEEKEWRKRETVLRKE--------EEKLQEEE 264 Query: 1694 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1753 +R R++Q E ++ EL+ +R ++ +L R Q + RE+ E R +Q Sbjct: 265 PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324 Query: 1754 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1813 Q E+ E E++L R Q + E R Q EE +Q+ + E E+++++ RE + R Sbjct: 325 QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384 Query: 1814 GKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLEE 1871 E+Q R+++L EQ+L +++QL +Q+L EQ+L R + EQ E++ + E Sbjct: 385 --REQQLRREQQLRREQQLRREQQLRR---EQQLRREQQLRREQQLRREQEEERHEQKHE 439 Query: 1872 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1931 + R QR ++R L+ E R E E R +EE R + +LE E Sbjct: 440 QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER---RERWLKLEEEER 496 Query: 1932 RFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1989 R ++ E +LR EE + QR + EE+ +QR +E+ L + E LK E Sbjct: 497 REQQERRE-QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL-LKREE 554 Query: 1990 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQK 2047 E L E+E +RL+R E+ Q + EE+ Q K + EERL Q K + E Q+ Sbjct: 555 EKRL-EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613 Query: 2048 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------IRSNAEDTLRSKEQ 2101 E L++ EE L S E+ + +L E R E+ L + + Sbjct: 614 ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673 Query: 2102 AELEAARQRQLAAEEERRRREAEERVQKSLAA-EEEAARQRKAALEEVERLKAKVEEARR 2160 E E R+ Q AEEE + +A ER++ + + + + A +V K E RR Sbjct: 674 REHEEERREQELAEEE--QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731 Query: 2161 LRERAEQESARQLQL---AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2217 +E+ E+ R+ +L +E A ++ Q EE+ F Q + +E + +Q S LR Sbjct: 732 RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLR 791 Query: 2218 GEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAAAE 2273 + E RA E + E+ + E E Q RRQ E E+ Q EEQ Q R +AQ E Sbjct: 792 EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851 Query: 2274 KLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQVEQELTTLRLQ 2331 + E + RR+Q ++ + + + E + +H +A+ L+++ + EQ+L LQ Sbjct: 852 EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL----LQ 907 Query: 2332 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2391 EE + Q+ +E +R + E R+ Q+++E + + E + + R + Sbjct: 908 EEEEELQR---EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964 Query: 2392 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2451 L+ K+ ++ L EE EK ++ E + + L EE ++R E+ ++ Sbjct: 965 KLQQKE--EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022 Query: 2452 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE--QMAQQLAEETQGFQRTLEAER 2509 K + QE +L E +++K QE+ R+ +E++E Q +QL E + +R E ER Sbjct: 1023 KDELQQEEEQLLRE----EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078 Query: 2510 Q--RQLEMSAEAERLKLRVAEMSR-----AQARAEEDAQRFRKQ-AEEIGEKLHRTELAT 2561 Q ++ E+ E E+L E R Q R EE+ Q+ +Q E EK R EL Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138 Query: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2621 Q + E ++ + +R R+ + RE+E+LQQE + L + +E + ++E+ Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198 Query: 2622 LQETQALQQ------------------SFLSEKDSLL----------QRERFIEQEKAKL 2653 +E + LQ+ + EK++ + + E+F + E ++L Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258 Query: 2654 --EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711 Q QD + +E + Q+++ Q+R R E+ R + + + RK +E + Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318 Query: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2750 QL ++ R+++ E +++ RE+ QLL+E+ L E Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357 Score = 311 bits (797), Expect = 1e-83 Identities = 327/1201 (27%), Positives = 577/1201 (48%), Gaps = 139/1201 (11%) Query: 1606 GGAEGELQALRARAEEAEA--QKRQAQEEAERLR---RQVQDESQRKRQAEVELASRVKA 1660 G A G + RAR + E+ Q R+ +E+ R RQ+++E ++R+ + + R A Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149 Query: 1661 EAEAAREKQRALQAL------EELRLQAEE-AERRLRQAEVERARQVQVALETAQRSAEA 1713 E E EKQ L+ EEL Q +E ER R+AE E+ + + ET + E Sbjct: 150 EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK-GHETEEFPDEE 208 Query: 1714 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1773 +L+ + + +L R +EE Q RE +R Q++ E E + E E +L Sbjct: 209 QLRRR------ELLELRRKGREE--KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260 Query: 1774 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1833 + E R R EE Q + L + E ++++E E++ +R + ++ +Q E ++ E+ Sbjct: 261 QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320 Query: 1834 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1893 +R+ E QQ EQ+L R +Q + E++L R Q E Q R+E E E Sbjct: 321 RREQQERREQQEERREQQLRR---------EQEERREQQLRREQEEERREQQLRREQEEE 371 Query: 1894 LAKVRAEMEVLLASKARAEEESRSTSE-KSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1952 R E ++ + R E++ R + + +Q+L E RE ++ R + L E + Sbjct: 372 ----RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLRREQQL 425 Query: 1953 QRQLAEEDAARQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDE 2010 +R+ EE+ Q+ E ER ++L E R LK E E E+E ++L+R E+E Sbjct: 426 RRE-QEEERHEQKHEQER-REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE 483 Query: 2011 AFQR-RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 2069 +R +LEE+ + + E R QLR+ + E+ R +RQ EEE L + Sbjct: 484 RRERWLKLEEE--ERREQQERREQQLRREQEERREQ---------RLKRQEEEERLQQRL 532 Query: 2070 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ-LAAEEERRR----REAE 2124 E+ + E E L+ +E+ LE R+ Q L E+E RR + E Sbjct: 533 RSEQQLRREQE---------ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583 Query: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2184 ER Q+ L E+E +++ EEVERL+ + +RL+ +E RQ L E ++R Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643 Query: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQ 2243 Q + + QQ+ +E + ++E+ L+Q L+ E E RR E AEE + QA RE + Sbjct: 644 QQQLRRE----QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA-RERIK 698 Query: 2244 SR--RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2301 SR + + E + + + +R + Q E R+ EQE RR + + ++++ A Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQ---EGQRRRQEQEEKRRRRESELQWQEEERAH 755 Query: 2302 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2361 + ++ ++ + T + +A+ + E RL + L ++ ++L+AE + QR Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSA-----RPPLREQRERQLRAEERQQREQRF 810 Query: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR-----FLQEEAEKMKQVAEE 2416 EEE E+ + + R E E L +++ QR LQEE + +++ ++ Sbjct: 811 LPEEE--------EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE--DQ 860 Query: 2417 AARLSVAAQEAARLRQLAEEDLAQQR-------ALAEKMLKEKMQAVQEATRLKAEAELL 2469 R S + + R EE+ ++R AL E++ KE+ +E L+ E Sbjct: 861 ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE---- 916 Query: 2470 QQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2527 +++K QEQ R+ +E++ +Q +QL E + +R E ERQ + + + + +L Sbjct: 917 EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGE 976 Query: 2528 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2587 E + + + E R ++ ++ E+L R E + + Q E Q ++ D + ++ E Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR----QEWERQYRKKD-ELQQEEE 1031 Query: 2588 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2647 + EREK +LQ+ + Q + EE ++EQLL E + ++ E + ++E ++ Sbjct: 1032 QLLREEREKRRLQERER--QYREEEELQQEEEQLLGEERETRRR--QELERQYRKEEELQ 1087 Query: 2648 QEKAKLEQLFQDEVAK-AQQLREEQQRQQQQMEQERQRLVASMEEARR-----RQHEAEE 2701 QE+ EQL ++E K +Q RE Q R++++++QE ++L+ E RR RQ+ EE Sbjct: 1088 QEE---EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144 Query: 2702 GVRRKQEEL----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2751 V++++E+L Q+LE+Q R++EEL EE Q LRE+ + ++ EE Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204 Query: 2752 V 2752 + Sbjct: 1205 L 1205 Score = 217 bits (553), Expect = 2e-55 Identities = 251/968 (25%), Positives = 440/968 (45%), Gaps = 145/968 (14%) Query: 1978 AIGEATRLKTE-------AEIALKEKEAENERLR-----RLAEDEAFQRRRLEEQ----- 2020 A+G+AT L E E L+++ E ++ R R E+E QRRR + Q Sbjct: 88 ALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERE 147 Query: 2021 --AAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 2077 + +++ +ERL Q R+ D EL RQ+ ++ +RR EE++ + K + Sbjct: 148 LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER-EERRAEEEQLQSCKGHETEEFPD 206 Query: 2078 KAEL-ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAE 2134 + +L EL +R R ++Q + + R EEE+ R+RE R ++ E Sbjct: 207 EEQLRRRELLELRRKG----REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262 Query: 2135 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----QLQLAQEAAQKRLQAEEK 2189 EE RQR+ EE + K + +E RR R+ EQ+ R QL+ QE ++ Q E + Sbjct: 263 EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322 Query: 2190 AHAFAVQQKEQELQQTLQQEQSVL--DQLRGEAEAARR----AAEEAEEARVQAEREAAQ 2243 +Q+E+ +Q L++EQ QLR E E RR E+ EE R Q R Q Sbjct: 323 EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382 Query: 2244 SRRQ-----------VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---------- 2282 RR+ ++ R +Q EQ R Q ++LR+E E+E Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442 Query: 2283 AARRAQAEQAALRQKQAADAEMEKH-KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2341 +R + EQ R + E E+H ++ +Q L++ + E+ L+L+ EE Q+ Sbjct: 443 REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502 Query: 2342 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2401 +++L+R + E E +R + EE R+Q S+ + R E E R L ++ +R Sbjct: 503 REQQLRREQEERREQRLKRQEEEE-----RLQQRLRSEQQLRREQEERREQLLKREEEKR 557 Query: 2402 FLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-- 2458 QE E ++K+ EE + +E R ++L E Q+ L +++ +E+++ +++ Sbjct: 558 LEQERREQRLKREQEERRDQLLKREEERRQQRLKRE---QEERLEQRLKREEVERLEQEE 614 Query: 2459 --ATRLKAE-------AELL--QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2507 RLK E +LL ++Q+E Q+Q RR Q+++ + + EE + ++ L+ Sbjct: 615 RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674 Query: 2508 ERQ---RQLEMSAE-----AERLKLRV------------AEMSRAQARAEEDAQRFRKQA 2547 E + R+ E++ E ER+K R+ A S+ +R + + R+Q Sbjct: 675 EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734 Query: 2548 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ---QEAK 2604 +E + +EL QE+ + + + Q+ D + E +E R++ + +E + Sbjct: 735 QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR 794 Query: 2605 LLQLKSEEMQTVQQEQLLQETQALQQ-----------SFLSEKDSLLQRERFIEQEKAKL 2653 QL++EE Q +Q L +E + Q+ FL E++ L +RER +Q + + Sbjct: 795 ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRER-AQQLQEEE 853 Query: 2654 EQLFQDEVAKAQQLREEQQRQQQQMEQERQR-------LVASMEEARRRQ---HEAEEGV 2703 + L +D+ + Q + Q+ + Q+E+ER+R A E+ R+ Q E EE + Sbjct: 854 DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913 Query: 2704 RRKQEE---LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760 +R++ E Q+ E+Q R++E+L EE Q LRE+ + Q R Q Sbjct: 914 QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER----------ERQYRKD 963 Query: 2761 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ----GHTTV 2816 K L + L G E + R+ + +E +L E +R Q + Sbjct: 964 KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023 Query: 2817 DELARRED 2824 DEL + E+ Sbjct: 1024 DELQQEEE 1031 Score = 96.3 bits (238), Expect = 6e-19 Identities = 86/335 (25%), Positives = 166/335 (49%), Gaps = 42/335 (12%) Query: 2409 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2468 K+ Q A + E R R +E L Q R +E+ Q E + E E Sbjct: 80 KVAQACYYALGQATGLDEEKRARCDGKESLLQDRR------QEEDQRRFEPRDRQLEEEP 133 Query: 2469 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2528 Q++++ QEQ R L E +EQ +Q +R + +RQR+ E E + R Sbjct: 134 GQRRRQKRQEQERELAEGEEQSEKQ--------ERLEQRDRQRRDE-----ELWRQRQEW 180 Query: 2529 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2588 R + RAEE+ + K E E +E++ + LE++R+ + ++ RE Sbjct: 181 QEREERRAEEEQLQSCKGHET-------EEFPDEEQLRRRELLELRRKGREEKQQQRRE- 232 Query: 2589 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2648 ++++ QE + + + E ++E+ LQE + +Q L E++ L++ +E+ Sbjct: 233 ------RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK---LER 283 Query: 2649 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2708 ++ + E+ Q+E + Q+LR EQQ +++Q E+ R++ EE R +Q E+ R+++ Sbjct: 284 QELRRER--QEEEQQQQRLRREQQLRRKQEEERREQ----QEERREQQERREQQEERREQ 337 Query: 2709 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2743 +L++ +++RR+Q+ +E +R +QL+ +E+ R Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEER 372 Score = 37.4 bits (85), Expect = 0.35 Identities = 73/313 (23%), Positives = 122/313 (38%), Gaps = 57/313 (18%) Query: 518 EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 577 E+QL+ E E+L +R + Q E Q + L Q + +LL G+ P++ ER Sbjct: 933 EEQLQQEEEQLLREEREKRRRQER----ERQYRKDKKLQQKEEQLL--GEEPEKRRRQER 986 Query: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 637 + K L + Q L++ R + Q + R YR + L E LR Sbjct: 987 E-KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ-EEEQLLR--------- 1035 Query: 638 TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 697 + + LQ +R+ E+ + + LL E + R + +E Q Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE----------LERQYRKEEE 1085 Query: 698 LHQSIEEF-RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK--LLNSSKARLRSLES 754 L Q E+ R + E+ R E + R C +LQ + LL + + R E Sbjct: 1086 LQQEEEQLLREEPEKRRRQERE---------RQCREEEELQQEEEQLLREEREKRRRQEL 1136 Query: 755 LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 814 + +EEEEV + ++E +ELE + ++ +ELQ Sbjct: 1137 ERQY-------------REEEEV-----QQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178 Query: 815 AGDRLLREDHPAR 827 ++LLRE+ R Sbjct: 1179 EEEQLLREEQEKR 1191 >gi|156104874 envoplakin [Homo sapiens] Length = 2033 Score = 350 bits (899), Expect = 1e-95 Identities = 430/1813 (23%), Positives = 770/1813 (42%), Gaps = 258/1813 (14%) Query: 531 LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 590 L +++++Q A E + + LQ D + Q E R L +A+ +++ LF Sbjct: 39 LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98 Query: 591 NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 650 DV + +HPQ E++ + + +LHER+ EY + V P Sbjct: 99 LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147 Query: 651 RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 710 P ++ + + +E+ Q +V ++G + +E Q+ H L + I+ + ++ Sbjct: 148 -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196 Query: 711 RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 770 RS G + R YRD LL ++ R +SL SL++ + T++L L Sbjct: 197 --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243 Query: 771 EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 829 E++ + DWSD + + Y + EL +E+ + +L++ G+R++ HPA Sbjct: 244 EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303 Query: 830 VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 889 +++ Q AL+ +W L LC C E L+ Y +F + L KL L KYS Sbjct: 304 IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363 Query: 890 RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 949 +LLQ + E+++L + L +R++ V L R +P + L + ++ Sbjct: 364 PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421 Query: 950 CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 1009 CD+ EV + +G+ +LV P W V G P+ CF +P P+ +A +RL Sbjct: 422 CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481 Query: 1010 EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 1069 ++ QAL + +K+ A +SLR Q LA P+ Q+ L Sbjct: 482 ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535 Query: 1070 YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 1129 G G +R Q L SR + L+D+ Sbjct: 536 -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562 Query: 1130 RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1188 ++ + E L +KE A +EC ++ + A L Sbjct: 563 EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604 Query: 1189 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1247 LP + S++++ L L ++ +A+ LE+ ++ VIRG E Sbjct: 605 QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653 Query: 1248 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1307 L + +PA L+ + L++ R + QQ L L+ ++ LQ E Sbjct: 654 TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713 Query: 1308 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1367 ++ R + +V L +R+ AV Q D+R++ ++ + ++ D L +WL+ R Sbjct: 714 CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772 Query: 1368 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1427 Q P + +L+ ++ L +EI+ ++ A++DYELQ TY+ Sbjct: 773 ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829 Query: 1428 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI------------KF 1473 LEP S K+P+V ES+ + +L Y+E+ Q + K Sbjct: 830 CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKE 889 Query: 1474 ISETLRRMEE-------------EERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQA 1519 +SE +RR + E + Q EER+R+A V+ LE QR QL + Q Sbjct: 890 LSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQ- 948 Query: 1520 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1579 R + L+++ E R + + K ++EE ++ R +A+++ A++ Sbjct: 949 -----RPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR-RAGLQADLEVAAQKVVQ 1002 Query: 1580 AERSRLRIEEEIRVVRLQLEATERQRG-GAEGELQALRARAEEAEAQKRQAQEEAERLRR 1638 E R ++ + L E T+ +R G + + LR + ++ + E L++ Sbjct: 1003 LESKRKTMQPHL----LTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKK 1058 Query: 1639 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1698 ++ + KR+ +V+ VK E + ++A + LRLQ EE R +QAE E Sbjct: 1059 ELL--ALEKREVDVKEKVVVK-EVVKVEKNLEMVKAAQALRLQMEEDAARRKQAE-EAVA 1114 Query: 1699 QVQVALETAQRS----------AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1748 ++Q +E +R+ E + + +++++L L+EE A L E Sbjct: 1115 KLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELS 1174 Query: 1749 RRAQQQAEAERAREEA---ERELERWQL---KANEALRLRLQAEEVAQQKSLAQAEAEKQ 1802 + + E+ R + ER E +Q+ E RL+ + +E+A ++S + E EK Sbjct: 1175 DLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234 Query: 1803 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1862 + E +A++ V +E+ ++ + +R +E+ RL+A+ + Sbjct: 1235 LPDLEVL-----RAQKPTVEYKEVTQEVVRHERS---------PEVLREIDRLKAQLNEL 1280 Query: 1863 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1922 +E+L RLQ E R E E RA++E SK E Sbjct: 1281 VNSHGRSQEQLIRLQGE-------RDEWRRE----RAKVETKTVSKEVVRHEKDPV---- 1325 Query: 1923 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1982 LE EA R R+ EAA+ R AE+A + Q R++ E + V+ E + Sbjct: 1326 ---LEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV----- 1377 Query: 1983 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER--LAQLRKASD 2040 T+ + L+E E+ RL ++E +RR+LE + Q +A +EE+ L ++ Sbjct: 1378 ----TQKDPKLRE---EHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRS 1430 Query: 2041 SELERQKGLVEDTLR-----------QRRQVEEEILALKASFEKAAAGKAELELELGRIR 2089 +L ++ L + TLR Q + + EE++ L+ + + +A L +L + + Sbjct: 1431 KKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEA-LRWDLDQEK 1489 Query: 2090 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 2149 + + R + +++ ++ ++E+ +E RVQK E+E AR + E Sbjct: 1490 TQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEV-IRVQKDRVLEDERARVWEMLNRERT 1548 Query: 2150 RLKAKVEEARRLRERAEQ---------ESARQLQLAQEAAQK---RLQAEEKAHAFAVQQ 2197 +A+ EEARRLRER ++ +LQ A++ A + RLQ E +A Sbjct: 1549 ARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRA------L 1602 Query: 2198 KEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--- 2253 + Q+ QQTLQ QE+S L + E+E + A E +R++A + + Q+ E ER Sbjct: 1603 ERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEA--AILREKDQIYEKERTLR 1660 Query: 2254 ---LKQSAEEQAQ 2263 K S EE +Q Sbjct: 1661 DLHAKVSREELSQ 1673 Score = 264 bits (675), Expect = 1e-69 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%) Query: 4258 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4317 + ++ ++T ++ + ++ I++PETGK+MS YEAY++G+ID YL+L E EC+WEE Sbjct: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725 Query: 4318 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4377 +T S G +S+++DR+SG+QY I+ A+ I + Y+ G L I+EFA +++G Sbjct: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784 Query: 4378 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4432 S S S+GS S S SPA T S S +++ P+AGI DT T K SI Sbjct: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842 Query: 4433 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4492 A+ +N++D ITGQ+LLEAQA TGGI+D + ER+ V A+ +GL++ R+ AQKA Sbjct: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902 Query: 4493 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4552 F G EDP TK ++S +A++KGW+ E+ L+VQ+LTGGLI+P GR+P+ +AL G Sbjct: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962 Query: 4553 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4612 + AQ L+D +Y K LT P +K ++SYK+A+ R + +GL LL AA + + Y Sbjct: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022 Query: 4613 S 4613 S Sbjct: 2023 S 2023 Score = 260 bits (664), Expect = 3e-68 Identities = 458/2092 (21%), Positives = 840/2092 (40%), Gaps = 324/2092 (15%) Query: 1171 EGLGKGV-ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTIS 1229 +GL KG + S + P+ SP+ + + EL L + + + L+T Sbjct: 3 KGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQANADQVERDILETQK 62 Query: 1230 LVIRGTQGAEEVLRAHEEQ-----LKEAQAVPATL------------PELEATKASLKKL 1272 + + +E+ +Q LKEA+ + L P+ E + +K+L Sbjct: 63 RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122 Query: 1273 RAQAEAQQPTFDALRDELRGAQEVGER------LQQRHGERDVEVERWRERVAQLLERWQ 1326 + + + AL +++ +VG R L+Q+ ++ V ++ +A+L ++ Sbjct: 123 HERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQK--QKQVCAGQYGPGMAELEQQ-- 178 Query: 1327 AVLAQTDVRQRELEQLGRQLR------------YYRE---------------------SA 1353 +A+ ++ Q+E++ G+QLR YR+ Sbjct: 179 --IAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCT 236 Query: 1354 DPLGAWLQDARRRQEQIQAMPLADSQAVR---------EQLRQEQALLEEIERHGEKVEE 1404 L A + RR +Q + +AD VR E L QEQ++ ++E GE++ E Sbjct: 237 RQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSV-NQLEDDGERMVE 295 Query: 1405 CQRFAKQYINAIKD---YELQ-----LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1456 + A I A ++ E Q + + QL+ V + Q ++SV Q L Sbjct: 296 LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRR---FQEEADSVSQTLAKL 352 Query: 1457 RTHY-SELTTLTSQYIKFISETLRRME-EEERLAEQQRAE-ERERLAEVEAALEKQRQLA 1513 ++ ++ + +E L+++E EE+RLA +RA + +R + A L ++R Sbjct: 353 NSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPP 412 Query: 1514 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1573 + + + ++ E+Q E R + + +Q + +++ A Sbjct: 413 QQPLHVDSICDWDSGEVQLLQGE----RYKLVDNTDPHAWVVQGPGGETKRAPAACFCIP 468 Query: 1574 ARQAEAAERSRLRIEEEIRVVRLQLEATE-RQRGGAEGELQALRARAEEAEAQKRQAQEE 1632 A +A R+ R+ E++ ++ +L + R + A L+ + ++ QAQ+ Sbjct: 469 APDPDAVARAS-RLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKL 527 Query: 1633 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE---------ELRLQAE 1683 ++ R D Q +RQ V A A A + L+ LE RLQ+ Sbjct: 528 LTQMTRLDGDLGQIERQ--------VLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSL 579 Query: 1684 EAERRLRQAEVER----------ARQVQVALETAQRSAEAELQSKRASFAEKTA---QLE 1730 E+ Q E E A Q+ VAL + + +++Q + + EK LE Sbjct: 580 GTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKNKF-SDVQVLCSLYGEKAKAALDLE 638 Query: 1731 RSLQEEHVAV----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1786 R +Q+ + A L +EA A+ A ER +E + +R +L + LRL Sbjct: 639 RQIQDADRVIRGFEATLVQEAPIPAEPGALQERV---SELQRQRRELLEQQTCVLRLHRA 695 Query: 1787 EVAQQKSLAQAEAEKQK--EEAEREARR------RGKAEEQAVRQRELAEQELEKQRQLA 1838 A + + A + Q+ ++ R+ R+ R A + RE Q+ Q Sbjct: 696 LKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQF 755 Query: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQ-------RQLLEEELARLQREAAAATQKRQELE 1891 + + + L R + G Q ++ L +E+ +R+ A A+ Q L+ Sbjct: 756 KNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQ 815 Query: 1892 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1951 A L + + S E + + S + R+ + A+E +A E A Sbjct: 816 AALQDYELQADTYRCSL----EPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAA 869 Query: 1952 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 2011 Q+QL ++ ++ ++ L+E + +A + A +E EA +L + A Sbjct: 870 AQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVA 929 Query: 2012 FQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE---ILAL 2067 + LE Q +Q + + L +L + E R L R + QVEEE L Sbjct: 930 RVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGL 989 Query: 2068 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA-----ARQRQLAAEEERRRRE 2122 +A E AA +LE + R + L +KE ++E ++ QL + ++ R E Sbjct: 990 QADLEVAAQKVVQLESK----RKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGE 1045 Query: 2123 AE------ERVQKSLAAEE--EAARQRKAALEEVERLKAKVE---EARRLRERAEQESAR 2171 E ++K L A E E + K ++EV +++ +E A+ LR + E+++AR Sbjct: 1046 DAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAAR 1105 Query: 2172 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2231 + Q + A+ + + E+ A + + + +++ + EQ L E+ R EE Sbjct: 1106 RKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQD--PGLLQESSRLRSLLEEER 1163 Query: 2232 EARVQAEREAAQ--SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2289 RE + S+ V E +R K +E+ Q E EQE R Sbjct: 1164 TKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDP-------ETEQEITRLKAK 1216 Query: 2290 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2349 Q ++ + E+EK E QK VE + T + E + + E+ RL Sbjct: 1217 LQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPE---VLREIDRL 1273 Query: 2350 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILRDKDNTQRFLQEEA 2407 KA+ E + +E+L ++ + +E + +A++E + ++ ++ +KD L++EA Sbjct: 1274 KAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPV---LEKEA 1330 Query: 2408 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2467 E+++Q EAA+ AA++A +L +R L E+ E+ VQE + + + Sbjct: 1331 ERLRQEVREAAQKRRAAEDAVY-------ELQSKRLLLERRKPEEKVVVQEVVVTQKDPK 1383 Query: 2468 LLQQQKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2523 L ++ L+ +E RR Q + E + E Q + + +R ++L + E +L Sbjct: 1384 LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLT 1443 Query: 2524 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2583 LR+ E+ K+ + EK+ E+ EK LE + D + Sbjct: 1444 LRIQELE--------------KRPPTVQEKIIMEEVVKLEKDP---DLEKSTEALRWDLD 1486 Query: 2584 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2643 + + + EL RE + LQ + +LQ + +T+ +E + + + + + +L RE Sbjct: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRE 1546 Query: 2644 RFIEQEKAKLEQLFQDEVAKAQQL-----REEQ--QRQQQQMEQERQRLVASMEEARRRQ 2696 R Q + + + ++ + +A+ L REE QR + Q +QE RL +E R + Sbjct: 1547 RTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRL---QQELRALE 1603 Query: 2697 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL--------REQLQLLEEQH------ 2742 + ++ + QEE + L Q+ + + A+ Q L RE+ Q+ E++ Sbjct: 1604 RQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLH 1663 Query: 2743 ----RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG------------- 2785 R L+ + + ++ ++ D EA D Sbjct: 1664 AKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDW 1723 Query: 2786 ---------------LRRKVSAQRLQEAGI----LSAEELQRLAQGHTTVDELARREDVR 2826 L RK Q EA + +S EE GH + E A Sbjct: 1724 EEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGE 1783 Query: 2827 HYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT 2886 SI ++ K+ L+ A SP +L L + + D + + + Sbjct: 1784 TKPSSSLSIGSIISKSP---LASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCS 1840 Query: 2887 VNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQ 2946 + AV + ++ P KLL A+ A G D + ++ S+ +AM++GLI RLL AQ Sbjct: 1841 IKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQ 1900 Query: 2947 IA--------------------------------------TGGVIDPVHSHRVPVDVAYR 2968 A TGG+IDP + R+P+ A Sbjct: 1901 KAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALL 1960 Query: 2969 RGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLP 3020 G EE+ ++L D S K DP + E L+Y + + RC +DP +GL LLP Sbjct: 1961 SGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012 Score = 215 bits (548), Expect = 7e-55 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%) Query: 1709 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1766 R+A EL + Q+ER + E + Q L E + Q Q E R+ +EAE Sbjct: 33 RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92 Query: 1767 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1825 L+ L ++A RL+ QAEE+ +K + Q +E AE A V R Sbjct: 93 LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150 Query: 1826 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1884 + LE KQ+Q+ G +A E EQ + +L++E+ A Sbjct: 151 DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194 Query: 1885 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1933 Q R + + A +R++ LL + + + +R S ++Q+ + Sbjct: 195 QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254 Query: 1934 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1988 +L + A +R E K+ L++E + Q + ER++ + A+G LK E Sbjct: 255 SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314 Query: 1989 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 2048 + L + +L+ + + RR +E+A + + LA+L D++ G Sbjct: 315 WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365 Query: 2049 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 2105 L Q+ + EE+ LA+ ++ L + R+ + L + + Sbjct: 366 GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425 Query: 2106 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 2135 + + L E E +R A + V ++ LA+E Sbjct: 426 SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485 Query: 2136 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2195 +A +Q+ A ++ RLKA E+ R ++A S LA AQK L + Sbjct: 486 QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539 Query: 2196 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2248 Q + Q L + + L+ L G E A R + E+ Q E EA S R V Sbjct: 540 QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599 Query: 2249 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2308 A A + + L E +A+A RQ Q AD + Sbjct: 600 GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651 Query: 2309 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2361 E TL Q+A + E L+ ++ E Q+ L E+ + LKA A ++ Sbjct: 652 ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708 Query: 2362 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2421 +E + Q ++ L R A L LR+K +Q+ A +Q LS Sbjct: 709 NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763 Query: 2422 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2481 + R Q+ D Q A + K Q +Q R +A A L Q + A Q Sbjct: 764 SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821 Query: 2482 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2541 LQ D + + + +R A Q ++ A+ + L E++ AQ + + + Sbjct: 822 ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879 Query: 2542 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2597 RK E E+ E + RT HDA++ E+ A+ RE E Sbjct: 880 FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917 Query: 2598 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2654 +L++E K + E++ Q+ QLLQ L EK+ + R+ +E ++++ Sbjct: 918 KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976 Query: 2655 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2711 ++E + L+ + + Q Q+E +R+ + + Q E + G+ + +L+ Sbjct: 977 AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036 Query: 2712 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2771 QQ R ++ +++ + L+++L LE++ + E+V +V K N Sbjct: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091 Query: 2772 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2829 A + E D RRK + + + +A I E + V E+ + E L Sbjct: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149 Query: 2830 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2880 Q S + LL E+ + A L R+L + ++E Q F +DP Sbjct: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205 Query: 2881 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2916 + +T +A + + G P+L ++L A++ YK+ Sbjct: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263 Query: 2917 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2975 P ++I +A Q +V HG R E I G D R V+ + E Sbjct: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321 Query: 2976 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 3033 + VL ++ + E + E V + ++ LL K E+V Sbjct: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377 Query: 3034 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 3091 T + + E + +S + G+ + + E++ LL ++ R+ ++ VE+ Sbjct: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437 Query: 3092 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 3146 ++ + ++E E++ E +++ V+ E L++ ++R + Sbjct: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488 Query: 3147 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3206 +V + R + V V + Q+ +IY K+++ L + +A +++ Sbjct: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544 Query: 3207 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3258 +AR +E R A +G + + ++A RD + L Q L+ Sbjct: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600 Query: 3259 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3318 + R++ + L Q + + ++S R A RG +E SR Sbjct: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641 Query: 3319 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3378 E A E Q ++ L + A+ +EEL E Q RET T + + Sbjct: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688 Query: 3379 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3415 P +K G+ + + WE +++ E+ +L ++GK Sbjct: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746 Query: 3416 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3470 ++E ++ EE + L S V P+S L ++S++ Sbjct: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806 Query: 3471 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3529 T+ S LG L S +AGIY T K SI A+ + +L T LLEAQ Sbjct: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862 Query: 3530 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3589 AATG +VD + +R VH+A++ G++ ++LL+A+KA TG DP + +S+ +A+Q Sbjct: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922 Query: 3590 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3649 KG + R+ + L+ Q TGG+IDP + R+P+ A G SEE+ ++L D S K Sbjct: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982 Query: 3650 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3679 DP + E L+Y++ + RC +DP +GL LLP Sbjct: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012 Score = 132 bits (331), Expect = 1e-29 Identities = 68/186 (36%), Positives = 116/186 (62%) Query: 4072 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 4131 IAG++ T + S+ A+ K ++ P T +LLEAQAATG ++D + + +V +A+ G Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886 Query: 4132 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4191 ++ +LL+A++A TG +DP + K +S+ +A++KG + ++ + L+ Q TGG+ID Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946 Query: 4192 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4251 P+ + R+P++ A G+ EE+ ++L D S K DP ++E L+Y + M RC DP + Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006 Query: 4252 GLCLLP 4257 GL LLP Sbjct: 2007 GLLLLP 2012 Score = 127 bits (320), Expect = 2e-28 Identities = 73/193 (37%), Positives = 111/193 (57%) Query: 3163 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3222 IAG++ K SI A+ K++L LLEAQA TG I+D + R +V +A+ G Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886 Query: 3223 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3282 L+ ++LL+A+KA TG DP T + +S+ +A++KG +PRE L L Q TGG++D Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946 Query: 3283 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3342 P ++ R+P+ A G + EE ++ L + K +DP + E +Y E RCR D L+ Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006 Query: 3343 GLSLLPLSEKAAR 3355 GL LLP + + R Sbjct: 2007 GLLLLPAALEGYR 2019 Score = 121 bits (304), Expect = 1e-26 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%) Query: 3829 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3888 +AG+Y + SI A+ K +L + LLEAQAATG ++D + ER +V +A+ +G Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886 Query: 3889 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3948 L+ RLL+A++A TG DP T++ +S+ +A++K +P E L L Q TGG++D Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946 Query: 3949 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 4007 P+ +P++ A G ++++ L E S + DP + ERLSY + + RCR+D + Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006 Query: 4008 GQLLLP 4013 G LLLP Sbjct: 2007 GLLLLP 2012 Score = 52.8 bits (125), Expect = 8e-06 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%) Query: 3118 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3172 + +LLE++ + L R SV R + E + +R L G+ Sbjct: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912 Query: 3173 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3232 ++LS+ A++K +P + + L+ Q TG +IDP + R+ + +A+ +G++ E + L Sbjct: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972 Query: 3233 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3275 DP + + +S +A+ + GL LL A L Sbjct: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015 Score = 52.4 bits (124), Expect = 1e-05 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%) Query: 3784 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3838 +T + L EA+ + +LL S+ +A+E S L + G+ P ++ Sbjct: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912 Query: 3839 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3898 + LS+ +A++KG + E L+ Q TG L+DP + R+ + +A+ G++ EL L Sbjct: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972 Query: 3899 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3941 DP +++ +S +AM + L LL A L Sbjct: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015 Score = 47.4 bits (111), Expect = 3e-04 Identities = 32/110 (29%), Positives = 51/110 (46%) Query: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194 P F L + G D + S+ A+ K ++ G +LLEAQ ATGGI+D Sbjct: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873 Query: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4244 R V A +RGL + + L + G DP T++ L+ + +++ Sbjct: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923 >gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [Homo sapiens] Length = 2564 Score = 304 bits (778), Expect = 2e-81 Identities = 242/804 (30%), Positives = 377/804 (46%), Gaps = 79/804 (9%) Query: 175 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE-KGRMR 233 DER+ VQKKTFTKWVN HL + HI DLY DLRDG L LLEVLSG+ LPR +GRMR Sbjct: 57 DEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRPTRGRMR 116 Query: 234 FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS- 292 H L+NV AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI I++ + Sbjct: 117 IHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVIKIETEDN 176 Query: 293 -EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQT 351 E +AK+ LLLW Q GY + NFT+SWRDG FNA+IHRH+P L+D +K+ + Sbjct: 177 RETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDFSKLTKSN 236 Query: 352 NLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQ-DGVR 410 NL +AF AE+ LG+ RLLDPEDV++ PDEKSIITYV S Y ++ + +G R Sbjct: 237 ANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKALAVEGKR 296 Query: 411 AN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 463 E+ + Y EL LL W+ ++F +S ++ F + Sbjct: 297 IGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQAFTAYCT 356 Query: 464 MELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVAILEREKQ 520 +E P K +K + + S++ ++A +L VP G D++K WG+L A ERE Sbjct: 357 LEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKAEHEREAA 416 Query: 521 LRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQRAGEVER 577 LR+E R E L+ + + + + E LN+ L+ D L A ++ +E Sbjct: 417 LRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMKKHEAIEA 476 Query: 578 DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 637 D+ + ++ + Q L + Y + R+ + ++ ++ L L V A Sbjct: 477 DIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LTGLVGARR 528 Query: 638 TQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 696 T++ Q + LQ V + + Y+ D W+EE Q ++ E G L + L H Sbjct: 529 TRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEADDLLQKHG 578 Query: 697 GLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDLQYAKLLN 743 L I ++E + + Q+ CL L Q A+ Sbjct: 579 LLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAAR--- 635 Query: 744 SSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWSDRNTNMT 789 +A L + SL + + + W +KE G + + T Sbjct: 636 -RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHDLSST 694 Query: 790 AK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ--------AALQTQ 840 A+ + L EL + +++ G+ L+ P ++ A+ + + Sbjct: 695 ARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRR 754 Query: 841 WSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDL 900 W + + E L+E A QF +D+ +G L L++A R + D L Sbjct: 755 WQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHDEASSRRL 811 Query: 901 LQDAQDEKEQLNEYKGHLSGLAKR 924 + + ++ ++G +SGL ++ Sbjct: 812 ARQHRALTGEVEAHRGPVSGLRRQ 835 Score = 122 bits (306), Expect = 8e-27 Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%) Query: 1240 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1299 E++ +E++ V + E+ +A +++ R E+ AL+ L G + + Sbjct: 974 ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033 Query: 1300 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1348 L+ R E + ER+ + A+L + W A+ + + GR R+ Sbjct: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093 Query: 1349 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1406 + L A+L R QE PL +S L + ALL RH EE Sbjct: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140 Query: 1407 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1454 + + Y + E L A+L P +A P ++ G E+++Q ++ Sbjct: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200 Query: 1455 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1511 LR L L +Q + L E E+ + R+ L +E + +K + Sbjct: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257 Query: 1512 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1568 +A Q ++ Q+ + + + +E + AQQ QK Q ELQ LR E Sbjct: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317 Query: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628 + + A + +R E+ ++ + L + EL + E+ E + +Q Sbjct: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369 Query: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1688 +E L V+ + RQ EL S +A+A E +A Q ++ E +++ Sbjct: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425 Query: 1689 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1747 L E + L+ + A + S+ +Q+E +E AQ Sbjct: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477 Query: 1748 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1807 A ++ ER ER L R E RL L ++E+ Q E +E Sbjct: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536 Query: 1808 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1867 + QAV+Q Q L ++ Q ++ L L LR+ + E R+ Sbjct: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594 Query: 1868 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1915 LE+ + AA +++Q L+A ++A+V A E E+L+ S+ + ++E Sbjct: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653 Query: 1916 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1972 +ST + K+ L+ E G + E +A+ + + RAL E E +R++++ +R+ Sbjct: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709 Query: 1973 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 2031 L +GE R+ E + L + + L +AE E Q +H + ++E+ Sbjct: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768 Query: 2032 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 2090 SE + G+ + L Q+ +E++ + AAA AE + L + Sbjct: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817 Query: 2091 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 2150 E EL R + LAA E + ++ R + E+ R E Sbjct: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868 Query: 2151 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2210 + ++ R E Q Q++ QE A + HA A+ +EQE+ Q ++ Sbjct: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928 Query: 2211 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2259 S + R + A + R + ++ AA R V E L Q + Sbjct: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988 Query: 2260 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2315 + +AR ++L + + A QA L +K+ + ++H ++ +Q L Sbjct: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048 Query: 2316 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2370 Q+A V T + L ++ + +DE Q ++ EA R+ + EE FS Sbjct: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106 Query: 2371 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430 ++ + K+KA + +L ++F + E +AA+ A L Sbjct: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148 Query: 2431 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2489 R E L A L +++ R + + E LQ + + E R++ Sbjct: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208 Query: 2490 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2546 A + A ET E R R + E + AE L + R E + ++EE A+R R + Sbjct: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268 Query: 2547 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2606 +E E E A + + +E +R++ + ER + E+ + ++ +A L Sbjct: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324 Query: 2607 QL 2608 + Sbjct: 2325 DI 2326 Score = 122 bits (305), Expect = 1e-26 Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%) Query: 1153 ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1201 +REC Q + E + ++ + V L+A A + L P P + Sbjct: 560 SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619 Query: 1202 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1261 + + L +L++ + LE +++ +++ + AE R E L+ A A Sbjct: 620 NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679 Query: 1262 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1309 A A S +L AQ + Q R L+ A GE L G V Sbjct: 680 GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739 Query: 1310 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1369 + ER A RWQ + R+R L++ R L + D L WL+DA R Sbjct: 740 HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798 Query: 1370 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1429 D + R RQ +AL E+E H V +R Q Sbjct: 799 GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835 Query: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1485 L + + + + + E L +E+ L Q+++ R E E Sbjct: 836 LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895 Query: 1486 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1545 + E+++ R+ + +E + E+ Q ++ +QE V E Sbjct: 896 WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951 Query: 1546 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1594 + + RS Q+ L +Q ++ A + + E AE + ++R Sbjct: 952 HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006 Query: 1595 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1654 R +E+ R G + L L A + E ++ EEA L + ++ R Q EL Sbjct: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066 Query: 1655 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1693 + A A AA+ A+ A L+ ++A+EA L +A+ Sbjct: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126 Query: 1694 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1751 AR + E QR + + + A A A+L L A+ + E Sbjct: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181 Query: 1752 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1810 + AR EA + +QL LR QA V + + +A + AE E+ EA Sbjct: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237 Query: 1811 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1870 K + EL++Q+++ Q AEG LR GEQ ++ + Sbjct: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281 Query: 1871 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1924 L + Q A Q Q+L +L + E++ + K A + +R + K + Sbjct: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341 Query: 1925 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1984 R ELA+ L + E ++ Q E AA R + + + A + T+ Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400 Query: 1985 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 2043 K L E ++ ++ AE D+ + Q D+ +QL+K L Sbjct: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452 Query: 2044 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 2095 + + VE+ R+ +++ + AL AS E + A G+ + L L ++ Sbjct: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511 Query: 2096 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 2155 L SKE ++ +LA +ER + L A ++ ++ + E++ ++ Sbjct: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571 Query: 2156 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2212 EE + ERA ++ + A EA ++ L+ + A A A ++++Q L Q EQ Sbjct: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627 Query: 2213 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2271 D EA + E + + E+ Q ++ + E+ ++ EE AQ Q +A Sbjct: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687 Query: 2272 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2324 E ++EQ + R++Q ++ + K+ + + + + Q RQ +++ E+E Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747 Query: 2325 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2376 + +L + ++L E+ +E A R+R +Q+ +EL + M E Sbjct: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807 Query: 2377 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2430 AE RA +L +F + E Q+ E+ RL RL Sbjct: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860 Query: 2431 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2490 E R A M + ++A + +L +++ Q Q+ AQ + E E + Sbjct: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913 Query: 2491 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2544 A + E QG++ L A +L +S+ A+ L+ ++ M ++ + Sbjct: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973 Query: 2545 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2587 + E+ H +TEL A ++T Q L EIQ Q D R E Sbjct: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032 Query: 2588 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2643 + +R E LQQ ++ Q E + QE LLQ + S + E + L++R Sbjct: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090 Query: 2644 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2701 + A E+ F + ++++ EQ +Q R+ E A + Sbjct: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150 Query: 2702 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2758 G R E L RR + L AE R+ Q L+ E+ + + E+ + A Sbjct: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205 Query: 2759 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2797 A P DA + PA A E R+ SA R +E Sbjct: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242 Score = 102 bits (255), Expect = 7e-21 Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%) Query: 1261 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1320 EL A +A++KK EA + A + ++G E+ + L E ++ R + Sbjct: 460 ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512 Query: 1321 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1380 +L +W + R+ LEQ + ++E + W+++ Q Q+ + Sbjct: 513 VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568 Query: 1381 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1429 + L Q+ LLE +I E+VE A ++ + + + Q++ + A+ Sbjct: 569 EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628 Query: 1430 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1471 L+ A+ + S S +++QE + + + L T+ Sbjct: 629 LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688 Query: 1472 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1520 +S T R + + + L + E R A ++ AL +L A H Sbjct: 689 HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744 Query: 1521 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1577 A+ A+ QR++E RRE +A+ Q + L LR + Sbjct: 745 AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804 Query: 1578 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1627 EA+ R R + E+ R + RQ GGA G + AL+ R EAE Sbjct: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864 Query: 1628 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1680 + E A R+ ++D R EV E E R +L+++ + Sbjct: 865 EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924 Query: 1681 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1734 ++ L ++ VQ +E RS + L S+ E Q + + Sbjct: 925 SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984 Query: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1792 + + E AE RAQ + E RA E A R +W+L EA LQA E Q Sbjct: 985 AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040 Query: 1793 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1852 L +A ++ A+ AR AEE LA +A QR + + Sbjct: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099 Query: 1853 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1906 +RA+ G + L LEE A L R AA + Q E + A++ A E LLA Sbjct: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158 Query: 1907 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1934 + + E ++++ +A R + Sbjct: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218 Query: 1935 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1988 E+A A L EEA +Q + L + ++Q+ + AE L G E Sbjct: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278 Query: 1989 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 2036 A L EK EN+ + + + L+ H+ D I E++ R Sbjct: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338 Query: 2037 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 2088 +A +EL + K +E R+ +Q+ +E L AS K +LG I Sbjct: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388 Query: 2089 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 2142 R + E T ++K + EA++ QL AE +++ E ++Q + A Sbjct: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446 Query: 2143 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2202 + L++++ ++++VEE R + A+ L E A K L E + AV ++ L Sbjct: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500 Query: 2203 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262 + LQ+ + +L + + A +E A VQ A + + ++Q ++ Sbjct: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558 Query: 2263 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2316 R + QA +L + E+ A A+A + L Q Q+A A + + + +Q L Sbjct: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618 Query: 2317 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2376 QVEQ + + + L ++EL + + + + Q+ ++ + +E Sbjct: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672 Query: 2377 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2436 + A++ + RAL+ ++E++ + + RL VA +E R++A E Sbjct: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724 Query: 2437 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2491 + L + + V E AE E++ EL Q E LQE + A Sbjct: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776 Query: 2492 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2537 ++LA Q +E M+ + L AE+ +RAQ A Sbjct: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836 Query: 2538 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2593 DA+ + Q EE +L R + + + +++ + +HD + L + +L+ Sbjct: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895 Query: 2594 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2640 +L+ +E ++LQ E + + +L + A F S+ LL Sbjct: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955 Query: 2641 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2700 I + ++ +V+ + L Q + ++E L E R Sbjct: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013 Query: 2701 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2760 Q +L +L ++ + E + L++ L++ + A +A + + + Sbjct: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073 Query: 2761 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2796 + L + D ++ A A E F LRR + ++++ Sbjct: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117 Score = 99.8 bits (247), Expect = 6e-20 Identities = 341/1654 (20%), Positives = 617/1654 (37%), Gaps = 263/1654 (15%) Query: 662 LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 721 L LL W+ + ++G D S HR L +E R + R L Sbjct: 782 LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841 Query: 722 ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 773 A+ A + + + +A++ + R LR +++ +W+ EKE Sbjct: 842 ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901 Query: 774 EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 833 + + D ++ + + +L +E+ ++ ++ + L+ HP+ V S Sbjct: 902 QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961 Query: 834 QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 892 Q L ++W+ +++L +E +E +A + V E +++E R S R+ Sbjct: 962 QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018 Query: 893 ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 926 ++ LE LQ + + L E L+ LA A+ Sbjct: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078 Query: 927 AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 956 A + ++ + A G LP LLA + E Sbjct: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138 Query: 957 VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 1016 V + D ++V ++ +L++ G+E P E + LE L Sbjct: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184 Query: 1017 VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 1062 + LW + +Q RD++ ++R+ +A P ++ R Sbjct: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244 Query: 1063 LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 1122 L ++EL Q Q A G + + E+ + + + LE+ + + R Q+ Sbjct: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297 Query: 1123 ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1172 + +L D +L+L+ R H L ++ + ++ RE +R Q AE+ Sbjct: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355 Query: 1173 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1231 + + ++ E ++++ PE + + E+ +LE A L + + Sbjct: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415 Query: 1232 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1285 ++ ++ L E QL++ V + L +L++ ++ +++ + Q A Sbjct: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475 Query: 1286 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1345 L E + VGER Q GER V + + L ER + +LA +EL Q+ Sbjct: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523 Query: 1346 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1405 L D AW+Q+ R +Q QAV++ +++ Q L EI+ HG ++EE Sbjct: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574 Query: 1406 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1464 A + +++ E + V + LE + S A + + V+ + +Y ++ Sbjct: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631 Query: 1465 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1523 + + + L M E++ EQ + ++ ++E +E + +A+ Q +A Sbjct: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688 Query: 1524 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1577 E + +Q R Q +V R A + +++R E+ L QL RQ SE E ++ Sbjct: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748 Query: 1578 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1636 A + E + V++ + + G A E L A+ +E + A Sbjct: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804 Query: 1637 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1695 + +D +EL A+RE + EL+ Q EE RRL R Sbjct: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864 Query: 1696 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752 R +++ R+ E +LQ S+ E AQL EH RE + Q Sbjct: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922 Query: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1805 E A E+A + +ALR Q + +A Q A + E Sbjct: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978 Query: 1806 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1863 + K E +A QEL + L + + A+ + + R E +E+ + Sbjct: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038 Query: 1864 QQRQLLEE--ELARLQREAAAA----TQKRQELEA-ELAKVRAEMEVLLA-----SKARA 1911 + + L++ E+ + +EA A T + L++ EL E+E L+ KA A Sbjct: 2039 RHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAA 2098 Query: 1912 EEESRSTS------------EKSKQRLEAEAGRF-----RELAEEAARL-------RALA 1947 E R +S E+SKQ GR ELA +AA L R L Sbjct: 2099 AWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLE 2158 Query: 1948 EEAKRQRQLAEEDA------ARQRAEAERVLAEKLAAIGEAT-RLKTEAEIALKEKEAEN 2000 A+R + RQ + ER L ++ + E R++ A A E AE Sbjct: 2159 PLARRASDTLSAEVRTRVGYVRQELKPER-LQPRIDRLPEIPGRVEPAALPAAPEDAAET 2217 Query: 2001 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 2060 AE + R Q AD E L + R+ E Q E+ R+RR Sbjct: 2218 PATPAAAEQVRPRPER------QESADRAEELPRRRRPERQESVDQS---EEAARRRRPE 2268 Query: 2061 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 2120 +E +A +A L LGR ++E R+R+ RR Sbjct: 2269 RQE----------SAEHEAAHSLTLGRYE-------------QMERRRERR------ERR 2299 Query: 2121 REAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154 E +E ++ + + + + + VE+L+ K Sbjct: 2300 LERQESSEQEMPIRGDLVKGKATLADIVEQLQEK 2333 Score = 85.5 bits (210), Expect = 1e-15 Identities = 275/1239 (22%), Positives = 471/1239 (38%), Gaps = 168/1239 (13%) Query: 1160 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE----PSPAAPTLRSELELTLGKLEQVR 1215 +A + EV+ + AR+ A +E +LA P A LEL KL + Sbjct: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLW 1188 Query: 1216 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1275 L + L +R + A VLR E L A+ +P T+ +E + Sbjct: 1189 EARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAE-LPGTVESVEEALKQHRDFLTT 1247 Query: 1276 AEAQQPTFDALRDELRG-----------AQEVGERLQQRHGERDVEVERWRERVAQLLER 1324 E Q G AQE RL +++ E + ++W +++ LE Sbjct: 1248 MELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLEL 1307 Query: 1325 ------------W---QAVLAQTDVRQRELEQLGRQLRYYRESADPLG--AWLQDARRRQ 1367 W + ++A+ R+ + R LR+ A+ WL+ R Sbjct: 1308 QHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREG 1367 Query: 1368 EQIQAMPLADSQAVREQLRQEQALLEEIER----HGEKVEECQRFAKQYINAIKDYELQL 1423 +Q+ + +VR++L + + E+E ++ E + A Q + + + + +L Sbjct: 1368 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK-ADQLVQSFAELDKKL 1426 Query: 1424 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1483 + ++QL+ V V S + + + Y E+ L +Q E + Sbjct: 1427 LHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK--- 1483 Query: 1484 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVR 1540 E + E+Q A ERL + L+++R+L A + A EL Q+R+ + Sbjct: 1484 -ELVGERQNAVG-ERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT 1541 Query: 1541 REEAAVDAQQQ--------KRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1589 + A QQ +R IQ L+++ + + A ++ +AEA R +++ Sbjct: 1542 ERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS 1601 Query: 1590 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649 +R EA ER++ + Q + + AE + ++E + + Q Q Sbjct: 1602 AWAGLR---EAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 1658 Query: 1650 A---EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1706 ++L V+ E+ + R +AL E+ E R RQ++V+R + VAL+ Sbjct: 1659 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISR-RQSQVDR---LYVALKE 1714 Query: 1707 A--QRSAEAELQSKRASFAEKTAQLERSLQEEHVA------------VAQLREEAERRAQ 1752 +R E Q + + ++LE + E+ V V+ L+E+ A Sbjct: 1715 LGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS 1774 Query: 1753 QQAEAERAREEAEREL---------------ERWQLKANEA---------LRLRLQAEEV 1788 + A R R A ++ W+ NEA R +L A Sbjct: 1775 ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASR 1834 Query: 1789 AQQKSLAQA-EAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQ-RQL 1837 K + A E + Q EE R E R + ++ +R E Q L Q RQL Sbjct: 1835 ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQL 1894 Query: 1838 AEGTAQQRLAAEQELIRLRAETEQGEQQ--RQLLEE-ELARLQREAAAATQKRQELEAEL 1894 EG AQ R E A EQ Q ++LL E ARL ++T +++ Sbjct: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLH---VSSTADALRFHSQV 1951 Query: 1895 AKVRAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFRELAEEAARLRA 1945 + + M+ + AS+ A ++ R S K LEA +E R Sbjct: 1952 RDLLSWMDGI-ASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTT-CQELGRSLL 2009 Query: 1946 LAEEAKRQRQLAEEDAARQRAEAERVLAEK-------LAAIGEATRLKTEAEIALKEKEA 1998 L + A A+ D R E ++EK L + E + EA +A A Sbjct: 2010 LNKSAMADEIQAQLDKLGTRKEE---VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTA 2066 Query: 1999 ENERL--RRLAE--DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE---LERQKGLVE 2051 + L R L DE Q R E + A EER + LR+ + E E+ K Sbjct: 2067 QEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPT 2126 Query: 2052 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 2111 L ++ + LA KA+ G E L + A DTL ++ + + RQ + Sbjct: 2127 PLLGRKFFGDPTELAAKAAPLLRPGG---YERGLEPLARRASDTLSAEVRTRVGYVRQ-E 2182 Query: 2112 LAAEEERRR----REAEERVQKSL--AAEEEAARQ--RKAALEEVERLKAKVEEARRLRE 2163 L E + R E RV+ + AA E+AA AA E+V + E A + Sbjct: 2183 LKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESA----D 2238 Query: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223 RAE+ R+ QE+ + +A + + E E +L + + R E Sbjct: 2239 RAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRER 2298 Query: 2224 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2262 R +E+ E + + + + + A+ ++Q E++A Sbjct: 2299 RLERQESSEQEMPIRGDLVKGKATL--ADIVEQLQEKEA 2335 Score = 81.6 bits (200), Expect = 2e-14 Identities = 245/1111 (22%), Positives = 423/1111 (38%), Gaps = 161/1111 (14%) Query: 1000 QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLK--PE 1057 ++AQEAVTRL ++Q Q + L Q RD + W + Sbjct: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333 Query: 1058 EQRQALHSLELHYQAFL--------------RDSQDAGGFGPEDRLMAEREYGSCSHHYQ 1103 E LH L +QAF+ R+ Q PE ++ G + Sbjct: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG----EIR 1389 Query: 1104 QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRI 1160 Q LE Q ++R S+ + + + +H D +P + A ++ Sbjct: 1390 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 1449 Query: 1161 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1220 + Q +++VE + V L A+ ALP PA+ L E + +G+ VR Sbjct: 1450 KKLQSMESQVEEWYREVGELQAQ---TAALP-LEPASKELVGERQNAVGE-RLVR----- 1499 Query: 1221 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ-AVPATLPE-----LEATKASLKK--- 1271 LE L+ ++ ++ +V +++L Q +P + L+A + +KK Sbjct: 1500 LLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQG 1559 Query: 1272 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1331 LR + +A P +EV ER R E E R + QL W + Sbjct: 1560 LRREIQAHGPRL----------EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREA 1609 Query: 1332 TDVRQRELEQLGRQLRYYRESADPLGAWL--------QDARRRQEQIQAMPLAD------ 1377 + RQ+ L+ + +YY + A+ + AWL + + + EQ L Sbjct: 1610 AERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 1668 Query: 1378 -----SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY-ELQLVTYKAQ-- 1429 +++ + RQ +ALLE E++ Q + A+K+ E + V + Q Sbjct: 1669 GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYW 1728 Query: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489 L ++ + + + V+ +L + ++ L ++ +F SET M ERLA Sbjct: 1729 LYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET--GMAGRERLAA 1786 Query: 1490 -QQRAEERERLAEVEAA--LEKQRQLAEAHAQ------AKAQ---AERE-------AKEL 1530 Q +E AA E + L EA A+ +AQ A RE A+EL Sbjct: 1787 VNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAREL 1846 Query: 1531 QQRMQEEVVR---------REEAAVDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQA 1577 Q +++E+ R +A Q+ R+ + +LQ Q+RQ E Q + A Sbjct: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYA 1906 Query: 1578 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1636 E AE R +E ++ + L A E R ALR +Q R + + Sbjct: 1907 GEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR-----FHSQVRDLLSWMDGI 1961 Query: 1637 RRQVQDESQRKRQAEVELASR----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1692 Q+ + + + VE+ +K E EA + Q L L + A QA Sbjct: 1962 ASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021 Query: 1693 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1752 ++++ ++ +E + + ++ ++ + QE VA A L A+ Sbjct: 2022 QLDKL--------GTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWL--TAQEPLL 2071 Query: 1753 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1812 Q E + +E E+ + R + A + + + ++ + +AE+ K+ R Sbjct: 2072 QSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGR 2131 Query: 1813 R--GKAEEQAVRQRELA-----EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1865 + G E A + L E+ LE + A T + +R + E+ + + Sbjct: 2132 KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPR 2191 Query: 1866 RQLLEEELARLQREA---------------AAATQKRQELEAELAKVRAEMEVLLASKAR 1910 L E R++ A AAA Q R E + + RAE L + R Sbjct: 2192 IDRLPEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEE---LPRRRR 2248 Query: 1911 AE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDAARQRAE 1967 E +ES SE++ +R E R EAA L E+ +R+R+ E RQ + Sbjct: 2249 PERQESVDQSEEAARRRRPE--RQESAEHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306 Query: 1968 AERVLAEKLAAIGEATRLKTEAEIALKEKEA 1998 + + G+AT + L+EKEA Sbjct: 2307 EQEMPIRGDLVKGKATLADIVEQ--LQEKEA 2335 Score = 81.3 bits (199), Expect = 2e-14 Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%) Query: 1653 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1708 E A+R +AE EA+R LQ LEE A + ER L A A A TA Sbjct: 631 EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690 Query: 1709 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1741 S+ A L ++ + + A L+++L+ EE VA Sbjct: 691 LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750 Query: 1742 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1796 Q EEA R +++ + RA + +L+ +A RL + + S + Sbjct: 751 ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810 Query: 1797 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1853 + + E EA R G + A L Q+ A+Q A E+ Sbjct: 811 LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870 Query: 1854 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1887 LR E GE+++ LL +++ +Q + Q+ Sbjct: 871 ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930 Query: 1888 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1938 L + V ++ L+ + +E RS + R +E R E++ Sbjct: 931 NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990 Query: 1939 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1981 E A +RA E +R Q +L+ +AA Q E + L E+ A + E Sbjct: 991 NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050 Query: 1982 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 2022 A RL AE A E A RL+R D +AF + Q A Sbjct: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110 Query: 2023 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 2081 E L + +D+ L R L E+ + QR + I+A AS AA AEL Sbjct: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165 Query: 2082 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 2124 LELG ++ E + QA L RQ + + Sbjct: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225 Query: 2125 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2184 E + ++ + EEA +Q + L +E + K++ A + E ++ + AQEA + L Sbjct: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284 Query: 2185 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2234 + ++ + QQ Q+L L+ + + D +L G + R + + Sbjct: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343 Query: 2235 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2294 ++ + A+ + E E++++ ++ Q + + A+ K E Q A QA Sbjct: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403 Query: 2295 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2354 RQ A A+Q ++ A+++++L + QL++ D +L Q K ++ Sbjct: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455 Query: 2355 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2414 E SQVEE V + + L +E ++ L+ Q + E ++ + Sbjct: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504 Query: 2415 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2474 +E RL +A++E L Q+A DL + A ++ L MQ + L+A + +++ + Sbjct: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559 Query: 2475 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2515 L +E RL+E E+ +A + E + +R LE AER++Q L+ Sbjct: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619 Query: 2516 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2558 + + E+ VAE MS + + E+ + K+ ++ + + E Sbjct: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679 Query: 2559 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2610 L+ Q + L + +I R+QS D RL A+ EL E + L+Q+ L QL S Sbjct: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737 Query: 2611 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2645 E + +++++ + L Q F L EK S + RER Sbjct: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797 Query: 2646 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2685 + + A+L +L RE + + Q Q+E++R+RL Sbjct: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857 Query: 2686 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2742 + + E R + +R + +LQ L Q RQ +E A+ E + + + Sbjct: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917 Query: 2743 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2802 + L +E+ ++ A + + DAL + + DG+ ++ A + + S Sbjct: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976 Query: 2803 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2836 E L QG T V EL +++ R L +S++A Sbjct: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016 Score = 66.6 bits (161), Expect = 5e-10 Identities = 277/1408 (19%), Positives = 520/1408 (36%), Gaps = 194/1408 (13%) Query: 519 KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 578 ++L +E+ L + + AG + L+ DA L VR A + G + Sbjct: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121 Query: 579 LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 637 L++AD+++ LK+ Q E+ Y R+ E L+A E L P Sbjct: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176 Query: 638 TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 690 ++ L + RR L + LR L+ L + + + GAE + SVE Sbjct: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236 Query: 691 QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 746 L HR ++E + K++ A ++ EG L A L+ L + + Sbjct: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296 Query: 747 --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 804 +L L F+ + W++EK D N + + + A M EL Sbjct: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355 Query: 805 KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 864 ++ +++++ G +L++E +V ++ W+ + L E + Q Sbjct: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415 Query: 865 FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 924 E + +L ++ L+ D + + L+ Q + Q+ E+ + L + Sbjct: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472 Query: 925 AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 983 A+ P PA + +Q V G+ +L+ P Q +L+S Sbjct: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516 Query: 984 SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 1041 + + E RL Q + L + + Q LRR++Q Sbjct: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567 Query: 1042 -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 1088 L R+ +LA+ R+ + E R+ L L+ + A LR++ + F E Sbjct: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626 Query: 1089 LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 1148 E + + L+ S ++G E+S Q L LQLE Sbjct: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667 Query: 1149 DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1207 VE + +A+LS + +L + P S +S+++ Sbjct: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708 Query: 1208 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1267 L+++ + LE+ + + R E + E V A PEL Sbjct: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760 Query: 1268 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1326 + L+ + +E T A R+ L ++ + L + + W++ L E W Sbjct: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817 Query: 1327 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1386 +L R +L R+L + A L +++ RRR ++ P A Q R Sbjct: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875 Query: 1387 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1446 +A +++ +V + Q A Q L+ V E +AS ++ +V G Sbjct: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924 Query: 1447 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1505 + ++ D R H S T+ ++F S+ + + +A Q A ++ R ++ VE Sbjct: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979 Query: 1506 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1562 L H K + E EL Q+ + ++ + A + Q Q + +++ Sbjct: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033 Query: 1563 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1622 + + + + E + ++ + + + + R+ G + E++ L R E Sbjct: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093 Query: 1623 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1682 +E LRR L + K +AE +++ L + Sbjct: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135 Query: 1683 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1733 + E + A + R + LE R A L ++ R + + + ER L Sbjct: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195 Query: 1734 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1788 E E A+ E+A A AE+ R ER Q A+ A EE+ Sbjct: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESADRA-------EEL 2243 Query: 1789 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1845 +++ + E+ Q EEA R R R+ AE +A L +++E++R+ E +++ Sbjct: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303 Query: 1846 LAAEQELIRLRAETEQGEQQRQLLEEEL 1873 ++EQE+ +R + +G+ + E+L Sbjct: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330 Score = 60.5 bits (145), Expect = 4e-08 Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%) Query: 430 QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 488 +W+RH E + E+IE Q ++ K EL A K + + LE Q Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400 Query: 489 AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 536 A ++ + + + +L +L E QL+ S+ ++L+ ++ V Sbjct: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460 Query: 537 KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 571 + E G + E+L + LQ RLL A K + Q Sbjct: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520 Query: 572 AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 617 A +++ +L + L N +Q ++ +H + Q RR + H ER Sbjct: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578 Query: 618 --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 669 L ++R+ ++ G+ + A + ++ +RR ++ D+ + Q ++ AW+ Sbjct: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637 Query: 670 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 718 E + + + G D S L H L Q +E + RA +E D Q Sbjct: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697 Query: 719 LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 773 +S ++D Y L + R +LE L+ ++ W+ EKE Sbjct: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749 Query: 774 --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 830 E+G D+ +++ +E +S E + +++ + D L+ H A T+ Sbjct: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805 Query: 831 ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 882 ++ L W+ +L+L L + +FFSD RE +GQ+++ + L Sbjct: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865 Query: 883 RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 933 R + T+ E LQ + QL E Y G H +A R + V+Q Sbjct: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922 Query: 934 RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 993 G LL+ C+ ++ V+ A H +V + S Sbjct: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966 Query: 994 LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 1046 P + +V L HQ L T +L + L Q L R + L +S Sbjct: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021 Query: 1047 SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 1099 L T K E + LE+H A DA ++ L+ RE GS Sbjct: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080 Query: 1100 HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1159 +QL++ E + + + S L+ + T+ +++ K+P R Sbjct: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131 Query: 1160 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1218 K + L A L L P A+ TL +E+ +G + Q Sbjct: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181 Query: 1219 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1278 +LK L R + E R L A P E AT A+ +++R + E Sbjct: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233 Query: 1279 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1332 Q+ A R E + + + E +R E + L R++ + + Sbjct: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293 Query: 1333 DVRQRELEQ 1341 + R+R LE+ Sbjct: 2294 ERRERRLER 2302 Score = 59.3 bits (142), Expect = 9e-08 Identities = 269/1244 (21%), Positives = 450/1244 (36%), Gaps = 196/1244 (15%) Query: 1870 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1929 E E A +REAA + ++ + EL R + +V + E + + + L A Sbjct: 405 ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464 Query: 1930 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---------LAAIG 1980 ++ A + A E + +LA+ AA + RV A++ L + Sbjct: 465 EAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLV 524 Query: 1981 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 2040 A R + E +AL++ E + + E Q + L + QH + ++ L Q + Sbjct: 525 GARRTRLEQNLALQK--VFQEMVYMVDWMEEMQAQLLSRECGQHLVEADD-LLQKHGLLE 581 Query: 2041 SELERQKGLVE---------DTLRQRRQVEEEILALKASF---------EKAAAGKAELE 2082 ++ Q VE L+ + + +++ + + E+AA +AELE Sbjct: 582 GDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELE 641 Query: 2083 LE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 2137 L + AE R KE+ LEAA A L++ Sbjct: 642 ASRSLWALLQELEEAESWARDKERL-LEAAGGGGAAGAAGAAGTAGGAH---DLSSTARL 697 Query: 2138 ARQRKAALEEVERLKAKVEEARRLRERAEQ---------ESARQLQLAQEAAQKRLQAEE 2188 Q K E+ +A +++A R E ++ + LA+ AA R + + Sbjct: 698 LAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQR 757 Query: 2189 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRR 2246 A A +++ + + L Q + LD L A R A + +A R A Q R Sbjct: 758 LEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRA 817 Query: 2247 QVEEAER--------LKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQAEQAALRQK 2297 E E +Q A + A A ++R EAEQ A E AALR++ Sbjct: 818 LTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAE--VTEVAALRRQ 875 Query: 2298 QAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRL-----QLEETDHQKNLLDEELQRLK 2350 DA + ++ F E + + EQ L ++R+ +E H+ LD+E+ L Sbjct: 876 WLRDA-LAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLM 934 Query: 2351 AEA-----------------------------------TEAARQRSQVEEELFSVRVQME 2375 E QR + + V + Sbjct: 935 GRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVL 994 Query: 2376 ELSKLKARIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQ 2425 E+++++A++ + RA+ + + LQ + + EEAA L+ Sbjct: 995 EVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPA 1054 Query: 2426 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2485 +AARL Q AEE A+ ALA A Q A A LQ R Sbjct: 1055 QAARLHQGAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLH 1095 Query: 2486 DKEQMAQQL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2543 D + L A+E G E LE EA+ L R A + + EED R Sbjct: 1096 DLDAFLDWLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARI 1149 Query: 2544 RKQAE--------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLR 2586 +E E+G E L EL + + L + +Q LR Sbjct: 1150 VAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLR 1209 Query: 2587 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQR 2642 +A+ L ++ L ++S E Q L Q +Q + + + L Q Sbjct: 1210 QALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQG 1269 Query: 2643 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE---- 2698 + EQ + + +L + + QLR +Q Q+ + E Q + E HE Sbjct: 1270 NIYGEQAQEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLM 1327 Query: 2699 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2758 A +G R E+ +L ++ + + +AE Q +E L+ +E + + + E+ AS Sbjct: 1328 ARDGTR---EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRK 1383 Query: 2759 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTT 2815 + L+ +A+ F+ + Q E +L E +LQ + G Sbjct: 1384 KLGEIRQCWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG--- 1439 Query: 2816 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG- 2874 +LA LQ S + E + AAL L P + ++ E Q A G Sbjct: 1440 -GDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGE 1495 Query: 2875 ---FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---A 2928 LL+P++ RR + + + V +L +L + + G + Q Sbjct: 1496 RLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIK 1555 Query: 2929 MQKGL--IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2970 +GL ++ HG RL E G + S R P A RRG Sbjct: 1556 KNQGLRREIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595 Score = 35.8 bits (81), Expect = 1.0 Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%) Query: 378 VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 434 +++ PD + I + V LY A+ + + + A E Q + V L W+ Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745 Query: 435 HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 494 FE + +L KF E A + R + Q ++ ++ G Sbjct: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802 Query: 495 PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 553 D + + W +L + R + L + E L + + + G EE+ + Sbjct: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858 Query: 554 ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 613 RL + A ++R L + ++LL + V+ L++G R VY Sbjct: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906 Query: 614 -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 669 H +A R + L+ + + A + A++ + S LR+ ++DLL+W+ Sbjct: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958 Query: 670 EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 722 + ++ A+ D+ SVE + H+GL +E E E RS ++ ++ Sbjct: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018 Query: 723 TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 773 + A D LG + ++ + L+ + +H F A WL +E Sbjct: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.129 0.349 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 159,503,067 Number of Sequences: 37866 Number of extensions: 7447851 Number of successful extensions: 175027 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 1096 Number of HSP's successfully gapped in prelim test: 1689 Number of HSP's that attempted gapping in prelim test: 30812 Number of HSP's gapped (non-prelim): 41171 length of query: 4684 length of database: 18,247,518 effective HSP length: 124 effective length of query: 4560 effective length of database: 13,552,134 effective search space: 61797731040 effective search space used: 61797731040 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.