Search of human proteins with 41322908

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|41322908 plectin 1 isoform 3 [Homo sapiens]
         (4525 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|41322908 plectin 1 isoform 3 [Homo sapiens]                       8658   0.0  
gi|41322923 plectin 1 isoform 11 [Homo sapiens]                      8632   0.0  
gi|41322912 plectin 1 isoform 2 [Homo sapiens]                       8632   0.0  
gi|47607492 plectin 1 isoform 1 [Homo sapiens]                       8632   0.0  
gi|41322919 plectin 1 isoform 8 [Homo sapiens]                       8631   0.0  
gi|41322914 plectin 1 isoform 10 [Homo sapiens]                      8630   0.0  
gi|41322910 plectin 1 isoform 7 [Homo sapiens]                       8630   0.0  
gi|41322916 plectin 1 isoform 6 [Homo sapiens]                       8630   0.0  
gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapi...  2363   0.0  
gi|33188445 microfilament and actin filament cross-linker protei...  1379   0.0  
gi|207452735 epiplakin 1 [Homo sapiens]                              1268   0.0  
gi|58530842 desmoplakin isoform II [Homo sapiens]                     964   0.0  
gi|58530840 desmoplakin isoform I [Homo sapiens]                      964   0.0  
gi|4502443 dystonin isoform 1e precursor [Homo sapiens]               921   0.0  
gi|221316624 dystonin isoform 4 [Homo sapiens]                        861   0.0  
gi|221316622 dystonin isoform 3 [Homo sapiens]                        861   0.0  
gi|221316618 dystonin isoform 2 [Homo sapiens]                        861   0.0  
gi|34577047 dystonin isoform 1 [Homo sapiens]                         861   0.0  
gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]             861   0.0  
gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]             787   0.0  
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]          431   e-119
gi|45439327 periplakin [Homo sapiens]                                 413   e-114
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ...   404   e-112
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ...   400   e-110
gi|67782321 spectrin beta isoform a [Homo sapiens]                    377   e-103
gi|67782319 spectrin beta isoform b [Homo sapiens]                    376   e-103
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]        358   5e-98
gi|148746195 trichohyalin [Homo sapiens]                              352   6e-96
gi|156104874 envoplakin [Homo sapiens]                                350   1e-95
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [...   307   1e-82

>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
          Length = 4525

 Score = 8658 bits (22466), Expect = 0.0
 Identities = 4525/4525 (100%), Positives = 4525/4525 (100%)

Query: 1    MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
            MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV
Sbjct: 1    MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60

Query: 61   LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
            LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL
Sbjct: 61   LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120

Query: 121  HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
            HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP
Sbjct: 121  HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180

Query: 181  LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
            LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM
Sbjct: 181  LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240

Query: 241  PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
            PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL
Sbjct: 241  PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300

Query: 301  KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
            KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK
Sbjct: 301  KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360

Query: 361  QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
            QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL
Sbjct: 361  QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420

Query: 421  DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 480
            DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ
Sbjct: 421  DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 480

Query: 481  VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 540
            VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH
Sbjct: 481  VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 540

Query: 541  QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 600
            QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV
Sbjct: 541  QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 600

Query: 601  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 660
            AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL
Sbjct: 601  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 660

Query: 661  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 720
            LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ
Sbjct: 661  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 720

Query: 721  EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 780
            EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP
Sbjct: 721  EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 780

Query: 781  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 840
            MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN
Sbjct: 781  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 840

Query: 841  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900
            QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ
Sbjct: 841  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900

Query: 901  RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC 960
            RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC
Sbjct: 901  RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC 960

Query: 961  QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1020
            QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR
Sbjct: 961  QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1020

Query: 1021 LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE 1080
            LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE
Sbjct: 1021 LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE 1080

Query: 1081 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1140
            EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER
Sbjct: 1081 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1140

Query: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200
            LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW
Sbjct: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200

Query: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
            LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY
Sbjct: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260

Query: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
            ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR
Sbjct: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320

Query: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
            RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV
Sbjct: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380

Query: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
            RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE
Sbjct: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440

Query: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
            ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK
Sbjct: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500

Query: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560
            AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR
Sbjct: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560

Query: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
            ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL
Sbjct: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620

Query: 1621 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
            RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE
Sbjct: 1621 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680

Query: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740
            GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA
Sbjct: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740

Query: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
            EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE
Sbjct: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800

Query: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
            DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE
Sbjct: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860

Query: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
            QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA
Sbjct: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920

Query: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980
            ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR
Sbjct: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980

Query: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
            QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040

Query: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2100
            QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE
Sbjct: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2100

Query: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160
            EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA
Sbjct: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160

Query: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220
            QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK
Sbjct: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220

Query: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
            LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA
Sbjct: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280

Query: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
            QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340

Query: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2400
            GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL
Sbjct: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2400

Query: 2401 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2460
            ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE
Sbjct: 2401 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2460

Query: 2461 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
            QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME
Sbjct: 2461 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520

Query: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
            QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE
Sbjct: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580

Query: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2640
            EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG
Sbjct: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2640

Query: 2641 ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2700
            ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS
Sbjct: 2641 ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2700

Query: 2701 PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT 2760
            PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT
Sbjct: 2701 PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT 2760

Query: 2761 GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV 2820
            GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV
Sbjct: 2761 GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV 2820

Query: 2821 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR 2880
            LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR
Sbjct: 2821 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR 2880

Query: 2881 DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV 2940
            DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV
Sbjct: 2881 DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV 2940

Query: 2941 VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3000
            VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG
Sbjct: 2941 VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3000

Query: 3001 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3060
            ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV
Sbjct: 3001 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3060

Query: 3061 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3120
            RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG
Sbjct: 3061 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3120

Query: 3121 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3180
            IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD
Sbjct: 3121 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3180

Query: 3181 QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF 3240
            QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF
Sbjct: 3181 QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF 3240

Query: 3241 TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV 3300
            TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV
Sbjct: 3241 TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV 3300

Query: 3301 LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA 3360
            LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA
Sbjct: 3301 LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA 3360

Query: 3361 TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG 3420
            TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG
Sbjct: 3361 TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG 3420

Query: 3421 STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL 3480
            STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL
Sbjct: 3421 STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL 3480

Query: 3481 ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE 3540
            ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE
Sbjct: 3481 ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE 3540

Query: 3541 TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII 3600
            TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII
Sbjct: 3541 TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII 3600

Query: 3601 IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA 3660
            IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA
Sbjct: 3601 IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA 3660

Query: 3661 WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL 3720
            WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL
Sbjct: 3661 WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL 3720

Query: 3721 TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA 3780
            TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA
Sbjct: 3721 TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA 3780

Query: 3781 QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR 3840
            QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR
Sbjct: 3781 QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR 3840

Query: 3841 RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT 3900
            RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT
Sbjct: 3841 RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT 3900

Query: 3901 KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 3960
            KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG
Sbjct: 3901 KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 3960

Query: 3961 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4020
            LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL
Sbjct: 3961 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4020

Query: 4021 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4080
            LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL
Sbjct: 4021 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4080

Query: 4081 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL 4140
            QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL
Sbjct: 4081 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL 4140

Query: 4141 IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY 4200
            IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY
Sbjct: 4141 IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY 4200

Query: 4201 RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG 4260
            RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG
Sbjct: 4201 RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG 4260

Query: 4261 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4320
            ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD
Sbjct: 4261 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4320

Query: 4321 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4380
            KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT
Sbjct: 4321 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4380

Query: 4381 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR 4440
            PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR
Sbjct: 4381 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR 4440

Query: 4441 LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY 4500
            LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY
Sbjct: 4441 LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY 4500

Query: 4501 SSSGYGRRYASGSSASLGGPESAVA 4525
            SSSGYGRRYASGSSASLGGPESAVA
Sbjct: 4501 SSSGYGRRYASGSSASLGGPESAVA 4525


>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
          Length = 4547

 Score = 8632 bits (22399), Expect = 0.0
 Identities = 4511/4511 (100%), Positives = 4511/4511 (100%)

Query: 15   KDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 74
            KDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR
Sbjct: 37   KDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 96

Query: 75   FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 134
            FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE
Sbjct: 97   FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 156

Query: 135  DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL 194
            DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL
Sbjct: 157  DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL 216

Query: 195  ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE 254
            ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE
Sbjct: 217  ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE 276

Query: 255  LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 314
            LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK
Sbjct: 277  LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 336

Query: 315  NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR 374
            NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR
Sbjct: 337  NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR 396

Query: 375  IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV 434
            IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV
Sbjct: 397  IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV 456

Query: 435  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 494
            QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE
Sbjct: 457  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 516

Query: 495  LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 554
            LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR
Sbjct: 517  LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 576

Query: 555  SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 614
            SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE
Sbjct: 577  SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636

Query: 615  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 674
            EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF
Sbjct: 637  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 696

Query: 675  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT 734
            QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT
Sbjct: 697  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT 756

Query: 735  VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK 794
            VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK
Sbjct: 757  VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK 816

Query: 795  QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 854
            QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH
Sbjct: 817  QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 876

Query: 855  QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 914
            QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF
Sbjct: 877  QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 936

Query: 915  LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL 974
            LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL
Sbjct: 937  LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL 996

Query: 975  EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP 1034
            EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP
Sbjct: 997  EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP 1056

Query: 1035 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1094
            SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ
Sbjct: 1057 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116

Query: 1095 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154
            AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176

Query: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
            WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236

Query: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1274
            PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
            ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1394
            EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1416

Query: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454
            SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
            ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536

Query: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
            ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634
            QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656

Query: 1635 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
            LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716

Query: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
            RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776

Query: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814
            ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836

Query: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874
            EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896

Query: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934
            QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956

Query: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994
            DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054
            KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114
            DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
            KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
            ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256

Query: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
            RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
            QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376

Query: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
            EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436

Query: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
            QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534
            SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594
            RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616

Query: 2595 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2654
            ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2676

Query: 2655 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2714
            TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2736

Query: 2715 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2774
            GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL
Sbjct: 2737 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2796

Query: 2775 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2834
            IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP
Sbjct: 2797 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2856

Query: 2835 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2894
            NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK
Sbjct: 2857 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2916

Query: 2895 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG 2954
            FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG
Sbjct: 2917 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG 2976

Query: 2955 LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ 3014
            LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ
Sbjct: 2977 LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ 3036

Query: 3015 KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL 3074
            KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL
Sbjct: 3037 KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL 3096

Query: 3075 SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV 3134
            SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV
Sbjct: 3097 SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV 3156

Query: 3135 ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA 3194
            ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA
Sbjct: 3157 ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA 3216

Query: 3195 ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT 3254
            ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT
Sbjct: 3217 ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT 3276

Query: 3255 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT 3314
            GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT
Sbjct: 3277 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT 3336

Query: 3315 TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG 3374
            TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG
Sbjct: 3337 TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG 3396

Query: 3375 FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV 3434
            FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV
Sbjct: 3397 FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV 3456

Query: 3435 LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN 3494
            LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN
Sbjct: 3457 LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN 3516

Query: 3495 THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG 3554
            THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG
Sbjct: 3517 THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG 3576

Query: 3555 GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG 3614
            GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG
Sbjct: 3577 GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG 3636

Query: 3615 LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY 3674
            LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY
Sbjct: 3637 LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY 3696

Query: 3675 LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE 3734
            LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE
Sbjct: 3697 LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE 3756

Query: 3735 LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF 3794
            LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF
Sbjct: 3757 LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF 3816

Query: 3795 HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 3854
            HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP
Sbjct: 3817 HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 3876

Query: 3855 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA 3914
            LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA
Sbjct: 3877 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA 3936

Query: 3915 GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV 3974
            GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV
Sbjct: 3937 GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV 3996

Query: 3975 GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE 4034
            GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE
Sbjct: 3997 GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE 4056

Query: 4035 ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL 4094
            ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL
Sbjct: 4057 ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL 4116

Query: 4095 CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC 4154
            CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC
Sbjct: 4117 CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC 4176

Query: 4155 EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML 4214
            EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML
Sbjct: 4177 EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML 4236

Query: 4215 SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE 4274
            SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE
Sbjct: 4237 SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE 4296

Query: 4275 AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF 4334
            AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF
Sbjct: 4297 AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF 4356

Query: 4335 CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT 4394
            CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT
Sbjct: 4357 CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT 4416

Query: 4395 VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS 4454
            VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS
Sbjct: 4417 VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS 4476

Query: 4455 PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS 4514
            PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS
Sbjct: 4477 PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS 4536

Query: 4515 ASLGGPESAVA 4525
            ASLGGPESAVA
Sbjct: 4537 ASLGGPESAVA 4547


>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
          Length = 4533

 Score = 8632 bits (22399), Expect = 0.0
 Identities = 4511/4511 (100%), Positives = 4511/4511 (100%)

Query: 15   KDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 74
            KDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR
Sbjct: 23   KDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 82

Query: 75   FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 134
            FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE
Sbjct: 83   FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 142

Query: 135  DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL 194
            DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL
Sbjct: 143  DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL 202

Query: 195  ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE 254
            ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE
Sbjct: 203  ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE 262

Query: 255  LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 314
            LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK
Sbjct: 263  LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 322

Query: 315  NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR 374
            NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR
Sbjct: 323  NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR 382

Query: 375  IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV 434
            IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV
Sbjct: 383  IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV 442

Query: 435  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 494
            QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE
Sbjct: 443  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 502

Query: 495  LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 554
            LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR
Sbjct: 503  LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 562

Query: 555  SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 614
            SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE
Sbjct: 563  SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 622

Query: 615  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 674
            EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF
Sbjct: 623  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 682

Query: 675  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT 734
            QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT
Sbjct: 683  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT 742

Query: 735  VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK 794
            VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK
Sbjct: 743  VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK 802

Query: 795  QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 854
            QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH
Sbjct: 803  QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 862

Query: 855  QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 914
            QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF
Sbjct: 863  QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 922

Query: 915  LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL 974
            LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL
Sbjct: 923  LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL 982

Query: 975  EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP 1034
            EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP
Sbjct: 983  EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP 1042

Query: 1035 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1094
            SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ
Sbjct: 1043 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1102

Query: 1095 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154
            AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER
Sbjct: 1103 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1162

Query: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
            WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1163 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1222

Query: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1274
            PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV
Sbjct: 1223 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1282

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
            ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA
Sbjct: 1283 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1342

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1394
            EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR
Sbjct: 1343 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1402

Query: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454
            SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ
Sbjct: 1403 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1462

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
            ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ
Sbjct: 1463 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522

Query: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
            ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL
Sbjct: 1523 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1582

Query: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634
            QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS
Sbjct: 1583 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1642

Query: 1635 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
            LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI
Sbjct: 1643 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1702

Query: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
            RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE
Sbjct: 1703 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1762

Query: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814
            ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA
Sbjct: 1763 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1822

Query: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874
            EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA
Sbjct: 1823 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1882

Query: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934
            QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE
Sbjct: 1883 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1942

Query: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994
            DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA
Sbjct: 1943 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2002

Query: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054
            KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL
Sbjct: 2003 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2062

Query: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114
            DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE
Sbjct: 2063 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2122

Query: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
            KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE
Sbjct: 2123 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2182

Query: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
            ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL
Sbjct: 2183 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2242

Query: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
            RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM
Sbjct: 2243 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2302

Query: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
            QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2362

Query: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
            EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI
Sbjct: 2363 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2422

Query: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
            QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL
Sbjct: 2423 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2482

Query: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534
            SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR
Sbjct: 2483 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2542

Query: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594
            RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT
Sbjct: 2543 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2602

Query: 2595 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2654
            ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH
Sbjct: 2603 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2662

Query: 2655 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2714
            TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS
Sbjct: 2663 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2722

Query: 2715 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2774
            GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL
Sbjct: 2723 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2782

Query: 2775 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2834
            IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP
Sbjct: 2783 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2842

Query: 2835 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2894
            NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK
Sbjct: 2843 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2902

Query: 2895 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG 2954
            FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG
Sbjct: 2903 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG 2962

Query: 2955 LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ 3014
            LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ
Sbjct: 2963 LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ 3022

Query: 3015 KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL 3074
            KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL
Sbjct: 3023 KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL 3082

Query: 3075 SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV 3134
            SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV
Sbjct: 3083 SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV 3142

Query: 3135 ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA 3194
            ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA
Sbjct: 3143 ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA 3202

Query: 3195 ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT 3254
            ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT
Sbjct: 3203 ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT 3262

Query: 3255 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT 3314
            GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT
Sbjct: 3263 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT 3322

Query: 3315 TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG 3374
            TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG
Sbjct: 3323 TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG 3382

Query: 3375 FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV 3434
            FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV
Sbjct: 3383 FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV 3442

Query: 3435 LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN 3494
            LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN
Sbjct: 3443 LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN 3502

Query: 3495 THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG 3554
            THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG
Sbjct: 3503 THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG 3562

Query: 3555 GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG 3614
            GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG
Sbjct: 3563 GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG 3622

Query: 3615 LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY 3674
            LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY
Sbjct: 3623 LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY 3682

Query: 3675 LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE 3734
            LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE
Sbjct: 3683 LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE 3742

Query: 3735 LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF 3794
            LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF
Sbjct: 3743 LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF 3802

Query: 3795 HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 3854
            HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP
Sbjct: 3803 HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 3862

Query: 3855 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA 3914
            LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA
Sbjct: 3863 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA 3922

Query: 3915 GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV 3974
            GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV
Sbjct: 3923 GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV 3982

Query: 3975 GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE 4034
            GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE
Sbjct: 3983 GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE 4042

Query: 4035 ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL 4094
            ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL
Sbjct: 4043 ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL 4102

Query: 4095 CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC 4154
            CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC
Sbjct: 4103 CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC 4162

Query: 4155 EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML 4214
            EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML
Sbjct: 4163 EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML 4222

Query: 4215 SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE 4274
            SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE
Sbjct: 4223 SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE 4282

Query: 4275 AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF 4334
            AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF
Sbjct: 4283 AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF 4342

Query: 4335 CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT 4394
            CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT
Sbjct: 4343 CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT 4402

Query: 4395 VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS 4454
            VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS
Sbjct: 4403 VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS 4462

Query: 4455 PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS 4514
            PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS
Sbjct: 4463 PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS 4522

Query: 4515 ASLGGPESAVA 4525
            ASLGGPESAVA
Sbjct: 4523 ASLGGPESAVA 4533


>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
          Length = 4574

 Score = 8632 bits (22398), Expect = 0.0
 Identities = 4512/4525 (99%), Positives = 4517/4525 (99%), Gaps = 3/4525 (0%)

Query: 1    MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
            +DP+   +  +  + DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV
Sbjct: 53   LDPA---ERAVIRIADERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 109

Query: 61   LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
            LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL
Sbjct: 110  LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 169

Query: 121  HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
            HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP
Sbjct: 170  HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 229

Query: 181  LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
            LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM
Sbjct: 230  LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 289

Query: 241  PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
            PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL
Sbjct: 290  PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 349

Query: 301  KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
            KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK
Sbjct: 350  KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 409

Query: 361  QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
            QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL
Sbjct: 410  QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 469

Query: 421  DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 480
            DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ
Sbjct: 470  DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQ 529

Query: 481  VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 540
            VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH
Sbjct: 530  VAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLH 589

Query: 541  QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 600
            QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV
Sbjct: 590  QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV 649

Query: 601  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 660
            AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL
Sbjct: 650  AAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRL 709

Query: 661  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 720
            LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ
Sbjct: 710  LREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQ 769

Query: 721  EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 780
            EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP
Sbjct: 770  EALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHP 829

Query: 781  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 840
            MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN
Sbjct: 830  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 889

Query: 841  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 900
            QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ
Sbjct: 890  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQ 949

Query: 901  RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC 960
            RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC
Sbjct: 950  RQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRC 1009

Query: 961  QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1020
            QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR
Sbjct: 1010 QRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR 1069

Query: 1021 LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE 1080
            LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE
Sbjct: 1070 LSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAE 1129

Query: 1081 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1140
            EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER
Sbjct: 1130 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1189

Query: 1141 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1200
            LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW
Sbjct: 1190 LQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAW 1249

Query: 1201 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1260
            LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY
Sbjct: 1250 LQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY 1309

Query: 1261 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1320
            ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR
Sbjct: 1310 ELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLR 1369

Query: 1321 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1380
            RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV
Sbjct: 1370 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVV 1429

Query: 1381 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1440
            RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE
Sbjct: 1430 RREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLE 1489

Query: 1441 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1500
            ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK
Sbjct: 1490 ATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVK 1549

Query: 1501 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1560
            AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR
Sbjct: 1550 AEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKR 1609

Query: 1561 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1620
            ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL
Sbjct: 1610 ASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEAL 1669

Query: 1621 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
            RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE
Sbjct: 1670 RLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1729

Query: 1681 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1740
            GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA
Sbjct: 1730 GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRA 1789

Query: 1741 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1800
            EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE
Sbjct: 1790 EMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1849

Query: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1860
            DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE
Sbjct: 1850 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1909

Query: 1861 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1920
            QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA
Sbjct: 1910 QAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKA 1969

Query: 1921 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980
            ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR
Sbjct: 1970 ELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029

Query: 1981 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
            QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE
Sbjct: 2030 QRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2089

Query: 2041 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2100
            QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE
Sbjct: 2090 QELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAE 2149

Query: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2160
            EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA
Sbjct: 2150 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA 2209

Query: 2161 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2220
            QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK
Sbjct: 2210 QVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK 2269

Query: 2221 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
            LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA
Sbjct: 2270 LKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329

Query: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
            QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389

Query: 2341 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2400
            GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL
Sbjct: 2390 GFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2449

Query: 2401 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2460
            ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE
Sbjct: 2450 ATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQE 2509

Query: 2461 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
            QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME
Sbjct: 2510 QLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2569

Query: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2580
            QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE
Sbjct: 2570 QERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE 2629

Query: 2581 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2640
            EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG
Sbjct: 2630 EQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG 2689

Query: 2641 ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2700
            ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS
Sbjct: 2690 ILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLS 2749

Query: 2701 PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT 2760
            PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT
Sbjct: 2750 PGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYT 2809

Query: 2761 GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV 2820
            GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV
Sbjct: 2810 GQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRV 2869

Query: 2821 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR 2880
            LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR
Sbjct: 2870 LADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEAR 2929

Query: 2881 DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV 2940
            DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV
Sbjct: 2930 DVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITV 2989

Query: 2941 VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3000
            VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG
Sbjct: 2990 VEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRG 3049

Query: 3001 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3060
            ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV
Sbjct: 3050 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3109

Query: 3061 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3120
            RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG
Sbjct: 3110 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3169

Query: 3121 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3180
            IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD
Sbjct: 3170 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3229

Query: 3181 QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF 3240
            QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF
Sbjct: 3230 QLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYF 3289

Query: 3241 TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV 3300
            TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV
Sbjct: 3290 TAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGV 3349

Query: 3301 LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA 3360
            LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA
Sbjct: 3350 LSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRA 3409

Query: 3361 TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG 3420
            TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG
Sbjct: 3410 TTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSG 3469

Query: 3421 STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL 3480
            STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL
Sbjct: 3470 STISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVL 3529

Query: 3481 ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE 3540
            ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE
Sbjct: 3530 ADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEE 3589

Query: 3541 TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII 3600
            TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII
Sbjct: 3590 TRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIII 3649

Query: 3601 IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA 3660
            IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA
Sbjct: 3650 IEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESA 3709

Query: 3661 WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL 3720
            WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL
Sbjct: 3710 WCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERL 3769

Query: 3721 TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA 3780
            TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA
Sbjct: 3770 TVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDA 3829

Query: 3781 QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR 3840
            QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR
Sbjct: 3830 QLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLR 3889

Query: 3841 RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT 3900
            RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT
Sbjct: 3890 RCRRDDGTGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVT 3949

Query: 3901 KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 3960
            KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG
Sbjct: 3950 KNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 4009

Query: 3961 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4020
            LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL
Sbjct: 4010 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4069

Query: 4021 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4080
            LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL
Sbjct: 4070 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4129

Query: 4081 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL 4140
            QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL
Sbjct: 4130 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGL 4189

Query: 4141 IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY 4200
            IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY
Sbjct: 4190 IDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQY 4249

Query: 4201 RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG 4260
            RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG
Sbjct: 4250 RAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAG 4309

Query: 4261 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4320
            ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD
Sbjct: 4310 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4369

Query: 4321 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4380
            KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT
Sbjct: 4370 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4429

Query: 4381 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR 4440
            PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR
Sbjct: 4430 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLR 4489

Query: 4441 LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY 4500
            LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY
Sbjct: 4490 LLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSY 4549

Query: 4501 SSSGYGRRYASGSSASLGGPESAVA 4525
            SSSGYGRRYASGSSASLGGPESAVA
Sbjct: 4550 SSSGYGRRYASGSSASLGGPESAVA 4574


>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
          Length = 4547

 Score = 8631 bits (22395), Expect = 0.0
 Identities = 4510/4511 (99%), Positives = 4511/4511 (100%)

Query: 15   KDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 74
            +DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR
Sbjct: 37   QDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR 96

Query: 75   FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 134
            FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE
Sbjct: 97   FHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 156

Query: 135  DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL 194
            DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL
Sbjct: 157  DMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNL 216

Query: 195  ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE 254
            ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE
Sbjct: 217  ENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANE 276

Query: 255  LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 314
            LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK
Sbjct: 277  LQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK 336

Query: 315  NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR 374
            NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR
Sbjct: 337  NRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQR 396

Query: 375  IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV 434
            IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV
Sbjct: 397  IVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDV 456

Query: 435  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 494
            QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE
Sbjct: 457  QTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPE 516

Query: 495  LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 554
            LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR
Sbjct: 517  LEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERAR 576

Query: 555  SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 614
            SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE
Sbjct: 577  SDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 636

Query: 615  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 674
            EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF
Sbjct: 637  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 696

Query: 675  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT 734
            QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT
Sbjct: 697  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT 756

Query: 735  VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK 794
            VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK
Sbjct: 757  VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYK 816

Query: 795  QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 854
            QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH
Sbjct: 817  QVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQH 876

Query: 855  QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 914
            QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF
Sbjct: 877  QALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAF 936

Query: 915  LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL 974
            LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL
Sbjct: 937  LRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL 996

Query: 975  EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP 1034
            EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP
Sbjct: 997  EACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP 1056

Query: 1035 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1094
            SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ
Sbjct: 1057 SPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ 1116

Query: 1095 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1154
            AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER
Sbjct: 1117 AVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVER 1176

Query: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
            WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1177 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1236

Query: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1274
            PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV
Sbjct: 1237 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPV 1296

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
            ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA
Sbjct: 1297 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1356

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1394
            EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR
Sbjct: 1357 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKR 1416

Query: 1395 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1454
            SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ
Sbjct: 1417 SIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ 1476

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
            ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ
Sbjct: 1477 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536

Query: 1515 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1574
            ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL
Sbjct: 1537 ALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL 1596

Query: 1575 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1634
            QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS
Sbjct: 1597 QEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1656

Query: 1635 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
            LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI
Sbjct: 1657 LAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1716

Query: 1695 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1754
            RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE
Sbjct: 1717 RLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEE 1776

Query: 1755 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1814
            ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA
Sbjct: 1777 ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLA 1836

Query: 1815 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1874
            EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA
Sbjct: 1837 EKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA 1896

Query: 1875 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1934
            QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE
Sbjct: 1897 QLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAE 1956

Query: 1935 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 1994
            DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA
Sbjct: 1957 DTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKA 2016

Query: 1995 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2054
            KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL
Sbjct: 2017 KVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL 2076

Query: 2055 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114
            DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE
Sbjct: 2077 DQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2136

Query: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2174
            KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE
Sbjct: 2137 KLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLE 2196

Query: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2234
            ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL
Sbjct: 2197 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALIL 2256

Query: 2235 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
            RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM
Sbjct: 2257 RDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2316

Query: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2354
            QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQL 2376

Query: 2355 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2414
            EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI
Sbjct: 2377 EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2436

Query: 2415 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
            QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL
Sbjct: 2437 QRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2496

Query: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2534
            SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR
Sbjct: 2497 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEAR 2556

Query: 2535 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2594
            RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT
Sbjct: 2557 RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVT 2616

Query: 2595 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2654
            ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH
Sbjct: 2617 ASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGH 2676

Query: 2655 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2714
            TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS
Sbjct: 2677 TTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAAS 2736

Query: 2715 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2774
            GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL
Sbjct: 2737 GFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGL 2796

Query: 2775 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2834
            IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP
Sbjct: 2797 IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDP 2856

Query: 2835 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2894
            NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK
Sbjct: 2857 NTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGK 2916

Query: 2895 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG 2954
            FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG
Sbjct: 2917 FQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEG 2976

Query: 2955 LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ 3014
            LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ
Sbjct: 2977 LRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQ 3036

Query: 3015 KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL 3074
            KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL
Sbjct: 3037 KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLL 3096

Query: 3075 SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV 3134
            SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV
Sbjct: 3097 SAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDV 3156

Query: 3135 ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA 3194
            ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA
Sbjct: 3157 ACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKA 3216

Query: 3195 ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT 3254
            ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT
Sbjct: 3217 ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT 3276

Query: 3255 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT 3314
            GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT
Sbjct: 3277 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKT 3336

Query: 3315 TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG 3374
            TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG
Sbjct: 3337 TVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATG 3396

Query: 3375 FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV 3434
            FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV
Sbjct: 3397 FLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLV 3456

Query: 3435 LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN 3494
            LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN
Sbjct: 3457 LRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPN 3516

Query: 3495 THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG 3554
            THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG
Sbjct: 3517 THENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPG 3576

Query: 3555 GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG 3614
            GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG
Sbjct: 3577 GGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQG 3636

Query: 3615 LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY 3674
            LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY
Sbjct: 3637 LASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVY 3696

Query: 3675 LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE 3734
            LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE
Sbjct: 3697 LPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE 3756

Query: 3735 LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF 3794
            LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF
Sbjct: 3757 LHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGF 3816

Query: 3795 HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 3854
            HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP
Sbjct: 3817 HLPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 3876

Query: 3855 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA 3914
            LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA
Sbjct: 3877 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIA 3936

Query: 3915 GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV 3974
            GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV
Sbjct: 3937 GVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIV 3996

Query: 3975 GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE 4034
            GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE
Sbjct: 3997 GPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPE 4056

Query: 4035 ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL 4094
            ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL
Sbjct: 4057 ESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGL 4116

Query: 4095 CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC 4154
            CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC
Sbjct: 4117 CLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQEC 4176

Query: 4155 EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML 4214
            EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML
Sbjct: 4177 EWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADML 4236

Query: 4215 SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE 4274
            SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE
Sbjct: 4237 SGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITE 4296

Query: 4275 AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF 4334
            AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF
Sbjct: 4297 AMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAF 4356

Query: 4335 CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT 4394
            CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT
Sbjct: 4357 CGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGT 4416

Query: 4395 VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS 4454
            VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS
Sbjct: 4417 VDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYS 4476

Query: 4455 PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS 4514
            PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS
Sbjct: 4477 PYSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSS 4536

Query: 4515 ASLGGPESAVA 4525
            ASLGGPESAVA
Sbjct: 4537 ASLGGPESAVA 4547


>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
          Length = 4551

 Score = 8630 bits (22394), Expect = 0.0
 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%)

Query: 16   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 75
            DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 42   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 101

Query: 76   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 135
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 102  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 161

Query: 136  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 195
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 162  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 221

Query: 196  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 255
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 222  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 281

Query: 256  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 282  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 341

Query: 316  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 375
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 342  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 401

Query: 376  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435
            VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 402  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 461

Query: 436  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 495
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 462  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 521

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS
Sbjct: 522  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 581

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 582  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 641

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 642  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 701

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV
Sbjct: 702  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 761

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 762  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 821

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ
Sbjct: 822  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 881

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 882  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 941

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 942  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1001

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 1002 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1061

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1062 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1121

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1122 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1181

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP
Sbjct: 1182 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1241

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
            LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA
Sbjct: 1242 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1301

Query: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335
            SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE
Sbjct: 1302 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1361

Query: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395
            ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS
Sbjct: 1362 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1421

Query: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
            IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA
Sbjct: 1422 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1481

Query: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
            LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA
Sbjct: 1482 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1541

Query: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
            LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ
Sbjct: 1542 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1601

Query: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1635
            EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL
Sbjct: 1602 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1661

Query: 1636 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1695
            AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR
Sbjct: 1662 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1721

Query: 1696 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1755
            LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE
Sbjct: 1722 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1781

Query: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815
            SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE
Sbjct: 1782 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1841

Query: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875
            KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ
Sbjct: 1842 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1901

Query: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935
            LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED
Sbjct: 1902 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1961

Query: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
            TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK
Sbjct: 1962 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2021

Query: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055
            VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD
Sbjct: 2022 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2081

Query: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
            QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK
Sbjct: 2082 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2141

Query: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
            LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE
Sbjct: 2142 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2201

Query: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2235
            TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR
Sbjct: 2202 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2261

Query: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295
            DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ
Sbjct: 2262 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2321

Query: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355
            AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE
Sbjct: 2322 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2381

Query: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415
            MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ
Sbjct: 2382 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2441

Query: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475
            RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS
Sbjct: 2442 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2501

Query: 2476 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
            EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR
Sbjct: 2502 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2561

Query: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595
            RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA
Sbjct: 2562 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2621

Query: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655
            SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT
Sbjct: 2622 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2681

Query: 2656 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2715
            TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG
Sbjct: 2682 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2741

Query: 2716 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2775
            FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI
Sbjct: 2742 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2801

Query: 2776 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2835
            VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN
Sbjct: 2802 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2861

Query: 2836 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2895
            THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF
Sbjct: 2862 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2921

Query: 2896 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2955
            QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL
Sbjct: 2922 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2981

Query: 2956 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3015
            RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK
Sbjct: 2982 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3041

Query: 3016 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3075
            LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS
Sbjct: 3042 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3101

Query: 3076 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3135
            AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA
Sbjct: 3102 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3161

Query: 3136 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3195
            CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA
Sbjct: 3162 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3221

Query: 3196 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3255
            RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG
Sbjct: 3222 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3281

Query: 3256 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3315
            KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT
Sbjct: 3282 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3341

Query: 3316 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3375
            VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF
Sbjct: 3342 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3401

Query: 3376 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3435
            LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL
Sbjct: 3402 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3461

Query: 3436 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3495
            RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT
Sbjct: 3462 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3521

Query: 3496 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3555
            HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG
Sbjct: 3522 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3581

Query: 3556 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3615
            GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL
Sbjct: 3582 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3641

Query: 3616 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3675
            ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL
Sbjct: 3642 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3701

Query: 3676 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3735
            PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL
Sbjct: 3702 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3761

Query: 3736 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3795
            HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH
Sbjct: 3762 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3821

Query: 3796 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3855
            LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL
Sbjct: 3822 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3881

Query: 3856 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3915
            SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG
Sbjct: 3882 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3941

Query: 3916 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3975
            VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG
Sbjct: 3942 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4001

Query: 3976 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4035
            PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE
Sbjct: 4002 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4061

Query: 4036 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4095
            SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC
Sbjct: 4062 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4121

Query: 4096 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4155
            LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE
Sbjct: 4122 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4181

Query: 4156 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4215
            WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS
Sbjct: 4182 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4241

Query: 4216 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4275
            GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA
Sbjct: 4242 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4301

Query: 4276 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4335
            MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC
Sbjct: 4302 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4361

Query: 4336 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4395
            GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV
Sbjct: 4362 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4421

Query: 4396 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4455
            DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP
Sbjct: 4422 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4481

Query: 4456 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4515
            YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA
Sbjct: 4482 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4541

Query: 4516 SLGGPESAVA 4525
            SLGGPESAVA
Sbjct: 4542 SLGGPESAVA 4551


>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
          Length = 4515

 Score = 8630 bits (22394), Expect = 0.0
 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%)

Query: 16   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 75
            DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 6    DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 65

Query: 76   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 135
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 66   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 125

Query: 136  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 195
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 126  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 185

Query: 196  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 255
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 186  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 245

Query: 256  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 246  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 305

Query: 316  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 375
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 306  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 365

Query: 376  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435
            VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 366  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 425

Query: 436  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 495
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 426  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 485

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS
Sbjct: 486  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 545

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 546  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 605

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 606  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 665

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV
Sbjct: 666  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 725

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 726  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 785

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ
Sbjct: 786  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 845

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 846  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 905

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 906  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 965

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 966  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1025

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1026 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1085

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1086 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1145

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP
Sbjct: 1146 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1205

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
            LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA
Sbjct: 1206 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1265

Query: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335
            SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE
Sbjct: 1266 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1325

Query: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395
            ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS
Sbjct: 1326 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1385

Query: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
            IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA
Sbjct: 1386 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1445

Query: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
            LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA
Sbjct: 1446 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1505

Query: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
            LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ
Sbjct: 1506 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1565

Query: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1635
            EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL
Sbjct: 1566 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1625

Query: 1636 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1695
            AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR
Sbjct: 1626 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1685

Query: 1696 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1755
            LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE
Sbjct: 1686 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1745

Query: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815
            SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE
Sbjct: 1746 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1805

Query: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875
            KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ
Sbjct: 1806 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1865

Query: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935
            LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED
Sbjct: 1866 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1925

Query: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
            TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK
Sbjct: 1926 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1985

Query: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055
            VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD
Sbjct: 1986 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2045

Query: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
            QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK
Sbjct: 2046 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2105

Query: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
            LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE
Sbjct: 2106 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2165

Query: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2235
            TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR
Sbjct: 2166 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2225

Query: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295
            DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ
Sbjct: 2226 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2285

Query: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355
            AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE
Sbjct: 2286 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2345

Query: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415
            MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ
Sbjct: 2346 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2405

Query: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475
            RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS
Sbjct: 2406 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2465

Query: 2476 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
            EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR
Sbjct: 2466 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2525

Query: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595
            RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA
Sbjct: 2526 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2585

Query: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655
            SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT
Sbjct: 2586 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2645

Query: 2656 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2715
            TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG
Sbjct: 2646 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2705

Query: 2716 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2775
            FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI
Sbjct: 2706 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2765

Query: 2776 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2835
            VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN
Sbjct: 2766 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2825

Query: 2836 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2895
            THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF
Sbjct: 2826 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2885

Query: 2896 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2955
            QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL
Sbjct: 2886 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2945

Query: 2956 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3015
            RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK
Sbjct: 2946 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3005

Query: 3016 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3075
            LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS
Sbjct: 3006 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3065

Query: 3076 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3135
            AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA
Sbjct: 3066 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3125

Query: 3136 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3195
            CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA
Sbjct: 3126 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3185

Query: 3196 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3255
            RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG
Sbjct: 3186 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3245

Query: 3256 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3315
            KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT
Sbjct: 3246 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3305

Query: 3316 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3375
            VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF
Sbjct: 3306 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3365

Query: 3376 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3435
            LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL
Sbjct: 3366 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3425

Query: 3436 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3495
            RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT
Sbjct: 3426 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3485

Query: 3496 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3555
            HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG
Sbjct: 3486 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3545

Query: 3556 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3615
            GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL
Sbjct: 3546 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3605

Query: 3616 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3675
            ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL
Sbjct: 3606 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3665

Query: 3676 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3735
            PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL
Sbjct: 3666 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3725

Query: 3736 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3795
            HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH
Sbjct: 3726 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3785

Query: 3796 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3855
            LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL
Sbjct: 3786 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3845

Query: 3856 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3915
            SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG
Sbjct: 3846 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3905

Query: 3916 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3975
            VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG
Sbjct: 3906 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3965

Query: 3976 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4035
            PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE
Sbjct: 3966 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4025

Query: 4036 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4095
            SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC
Sbjct: 4026 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4085

Query: 4096 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4155
            LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE
Sbjct: 4086 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4145

Query: 4156 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4215
            WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS
Sbjct: 4146 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4205

Query: 4216 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4275
            GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA
Sbjct: 4206 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4265

Query: 4276 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4335
            MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC
Sbjct: 4266 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4325

Query: 4336 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4395
            GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV
Sbjct: 4326 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4385

Query: 4396 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4455
            DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP
Sbjct: 4386 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4445

Query: 4456 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4515
            YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA
Sbjct: 4446 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4505

Query: 4516 SLGGPESAVA 4525
            SLGGPESAVA
Sbjct: 4506 SLGGPESAVA 4515


>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
          Length = 4684

 Score = 8630 bits (22394), Expect = 0.0
 Identities = 4510/4510 (100%), Positives = 4510/4510 (100%)

Query: 16   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 75
            DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 175  DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 234

Query: 76   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 135
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 235  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 294

Query: 136  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 195
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 295  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 354

Query: 196  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 255
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 355  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 414

Query: 256  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 415  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 474

Query: 316  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 375
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 475  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 534

Query: 376  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435
            VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 535  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 594

Query: 436  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 495
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 595  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 654

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS
Sbjct: 655  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 714

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 715  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 774

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 775  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 834

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV
Sbjct: 835  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 894

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 895  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 954

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ
Sbjct: 955  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 1014

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 1015 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1074

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 1075 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1134

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 1135 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1194

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1195 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1254

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1255 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1314

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP
Sbjct: 1315 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1374

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
            LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA
Sbjct: 1375 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1434

Query: 1276 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1335
            SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE
Sbjct: 1435 SPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAE 1494

Query: 1336 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1395
            ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS
Sbjct: 1495 ERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRS 1554

Query: 1396 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1455
            IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA
Sbjct: 1555 IQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQA 1614

Query: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
            LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA
Sbjct: 1615 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1674

Query: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
            LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ
Sbjct: 1675 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1734

Query: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1635
            EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL
Sbjct: 1735 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1794

Query: 1636 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1695
            AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR
Sbjct: 1795 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1854

Query: 1696 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1755
            LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE
Sbjct: 1855 LRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1914

Query: 1756 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1815
            SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE
Sbjct: 1915 SRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAE 1974

Query: 1816 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 1875
            KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ
Sbjct: 1975 KLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQ 2034

Query: 1876 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 1935
            LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED
Sbjct: 2035 LRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAED 2094

Query: 1936 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
            TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK
Sbjct: 2095 TLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAK 2154

Query: 1996 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2055
            VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD
Sbjct: 2155 VEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLD 2214

Query: 2056 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2115
            QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK
Sbjct: 2215 QLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEK 2274

Query: 2116 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2175
            LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE
Sbjct: 2275 LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE 2334

Query: 2176 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2235
            TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR
Sbjct: 2335 TDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILR 2394

Query: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2295
            DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ
Sbjct: 2395 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQ 2454

Query: 2296 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355
            AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE
Sbjct: 2455 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2514

Query: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415
            MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ
Sbjct: 2515 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2574

Query: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2475
            RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS
Sbjct: 2575 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLS 2634

Query: 2476 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2535
            EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR
Sbjct: 2635 EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARR 2694

Query: 2536 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2595
            RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA
Sbjct: 2695 RQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTA 2754

Query: 2596 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2655
            SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT
Sbjct: 2755 SQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHT 2814

Query: 2656 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2715
            TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG
Sbjct: 2815 TVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG 2874

Query: 2716 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2775
            FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI
Sbjct: 2875 FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLI 2934

Query: 2776 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2835
            VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN
Sbjct: 2935 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 2994

Query: 2836 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 2895
            THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF
Sbjct: 2995 THENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKF 3054

Query: 2896 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 2955
            QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL
Sbjct: 3055 QGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGL 3114

Query: 2956 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3015
            RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK
Sbjct: 3115 RSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQK 3174

Query: 3016 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3075
            LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS
Sbjct: 3175 LSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLS 3234

Query: 3076 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3135
            AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA
Sbjct: 3235 AEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVA 3294

Query: 3136 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3195
            CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA
Sbjct: 3295 CARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAA 3354

Query: 3196 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3255
            RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG
Sbjct: 3355 RARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTG 3414

Query: 3256 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3315
            KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT
Sbjct: 3415 KVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTT 3474

Query: 3316 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3375
            VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF
Sbjct: 3475 VKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGF 3534

Query: 3376 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3435
            LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL
Sbjct: 3535 LVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVL 3594

Query: 3436 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3495
            RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT
Sbjct: 3595 RQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNT 3654

Query: 3496 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3555
            HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG
Sbjct: 3655 HENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGG 3714

Query: 3556 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3615
            GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL
Sbjct: 3715 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3774

Query: 3616 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3675
            ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL
Sbjct: 3775 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3834

Query: 3676 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3735
            PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL
Sbjct: 3835 PGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPEL 3894

Query: 3736 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3795
            HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH
Sbjct: 3895 HDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH 3954

Query: 3796 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 3855
            LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL
Sbjct: 3955 LPLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL 4014

Query: 3856 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 3915
            SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG
Sbjct: 4015 SDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAG 4074

Query: 3916 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 3975
            VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG
Sbjct: 4075 VFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVG 4134

Query: 3976 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4035
            PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE
Sbjct: 4135 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4194

Query: 4036 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4095
            SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC
Sbjct: 4195 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4254

Query: 4096 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4155
            LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE
Sbjct: 4255 LLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECE 4314

Query: 4156 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4215
            WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS
Sbjct: 4315 WEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLS 4374

Query: 4216 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4275
            GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA
Sbjct: 4375 GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEA 4434

Query: 4276 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4335
            MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC
Sbjct: 4435 MHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFC 4494

Query: 4336 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4395
            GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV
Sbjct: 4495 GFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTV 4554

Query: 4396 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4455
            DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP
Sbjct: 4555 DARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSP 4614

Query: 4456 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4515
            YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA
Sbjct: 4615 YSVSGSGSTAGSRTGSRTGSRAGSRRGSFDATGSGFSMTFSSSSYSSSGYGRRYASGSSA 4674

Query: 4516 SLGGPESAVA 4525
            SLGGPESAVA
Sbjct: 4675 SLGGPESAVA 4684


>gi|169218211 PREDICTED: similar to plectin 1, partial [Homo sapiens]
          Length = 1369

 Score = 2363 bits (6124), Expect = 0.0
 Identities = 1193/1199 (99%), Positives = 1196/1199 (99%)

Query: 16   DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 75
            DERDRVQKKT TKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF
Sbjct: 171  DERDRVQKKTSTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF 230

Query: 76   HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 135
            HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED
Sbjct: 231  HKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSED 290

Query: 136  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 195
            MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE
Sbjct: 291  MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQTNLE 350

Query: 196  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 255
            NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL
Sbjct: 351  NLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQDGVRANEL 410

Query: 256  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315
            QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN
Sbjct: 411  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 470

Query: 316  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 375
            RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI
Sbjct: 471  RSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRSEFERLECLQRI 530

Query: 376  VTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 435
            VTKLQMEAGLCEEQL+QADALLQSD+RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ
Sbjct: 531  VTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQ 590

Query: 436  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 495
            TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL
Sbjct: 591  TLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPEL 650

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF+AKIERARS
Sbjct: 651  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFQAKIERARS 710

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
            DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE
Sbjct: 711  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 770

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ
Sbjct: 771  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 830

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRK SCDRSATV
Sbjct: 831  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKNSCDRSATV 890

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
            TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ
Sbjct: 891  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 950

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE QEAVTRLEAQHQ
Sbjct: 951  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQ 1010

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
            ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL
Sbjct: 1011 ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 1070

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
            RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE
Sbjct: 1071 RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 1130

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
            ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS
Sbjct: 1131 ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1190

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
            PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA
Sbjct: 1191 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1250

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW
Sbjct: 1251 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
            RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM
Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1369



 Score = 69.7 bits (169), Expect = 6e-11
 Identities = 249/1168 (21%), Positives = 440/1168 (37%), Gaps = 219/1168 (18%)

Query: 1500 KAEAEAAREK-----QRALQALEELRLQ---AEEAERRLRQAEVERARQVQVALETAQRS 1551
            ++E   A+EK     QR ++  + LR     +   + RL  A + R + + + +    R 
Sbjct: 287  QSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDMNKVYRQ 346

Query: 1552 AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELER 1611
               E   +  S AE+   + R L  E V V Q  E++             R    ++   
Sbjct: 347  TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPDVQD--- 403

Query: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAV--------R 1663
              ++ANE L+LR Q     ++  L   +  +    A  E R     EE  +        +
Sbjct: 404  -GVRANE-LQLRWQEY---RELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFK 458

Query: 1664 QRELAEQELEKQR-----QLAEGTAQQ-RLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
            + EL  +E +K R     Q  EG  Q  +L        L  E E G+    +LE E    
Sbjct: 459  EMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILERE---- 514

Query: 1718 QREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL 1777
                                           + R+E E     ++   +L+ EAG   E 
Sbjct: 515  ------------------------------KQLRSEFERLECLQRIVTKLQMEAGLCEEQ 544

Query: 1778 AEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEK 1837
              +A  L  L  +    R LA     ++  E ER L             K ++ I L   
Sbjct: 545  LHQADAL--LQSDI---RLLAAGKVPQRAGEVERDLD------------KADSMIRLLFN 587

Query: 1838 EAENERLRRLAEDEAFQRR--RLEEQAAQHKADIEERL--------AQLRKASDSELERQ 1887
            + +  +  R  + E   RR  RL E+    + +   RL         Q+ + +   ++R+
Sbjct: 588  DVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRR 647

Query: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGK--AELELELGRIRSNAEDTLRSKEQAEL 1945
              L + TLR  + +   +   +   + A  G     +E +LG  R   +     + QA++
Sbjct: 648  PELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSI--EEFQAKI 705

Query: 1946 EAAR--QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER-LKAKVEEARRL 2002
            E AR  + QL+       R+   R+    A    +++ R  +LE +   + A  +E   L
Sbjct: 706  ERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWL 765

Query: 2003 RERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT-LQQEQSVLDQLRGEA 2061
             E+ E+E      +  + + +      K  +++   +E EL++  +++ Q+  D+L  E 
Sbjct: 766  NEKEEEE------VGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 819

Query: 2062 EAARRAAEEAE-----------------EARVQAEREAAQSRRQVEEAERLKQSAEEQAQ 2104
              AR   E  +                 EA ++      Q    V EAE   Q  +E  +
Sbjct: 820  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 879

Query: 2105 ARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQ 2164
             +     +A   R E   +  + AQ E+  L + +   + + K  K   Q L+ +     
Sbjct: 880  RKNSCDRSATVTRLE---DLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQ-LKPRHPAHP 935

Query: 2165 ELTTLRL-------QLEETDHQKN--LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM 2215
                L L       Q+E T H+ +   L    Q    +   ++   + V    F V    
Sbjct: 936  MRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPN 995

Query: 2216 EELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLR 2272
            +E+ +   R+EA+++AL+         + Q   +    +A ++ R  V    +   A  R
Sbjct: 996  QEVQEAVTRLEAQHQALVTL-------WHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFR 1048

Query: 2273 QLAEEDLAQQRALAEKMLKEKMQAVQEA------TRLKAEAE----------LLQQQKEL 2316
             L  E+  Q     E   +  ++  Q+A       RL AE E          LLQ  ++ 
Sbjct: 1049 TLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQG 1108

Query: 2317 AQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQR-----QLEMSAE-AERLKLRVAEM 2370
            AQE++R          Q+   E +  +  LEA   R     +L +  E A     R+AE 
Sbjct: 1109 AQEESR---------CQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQ 1159

Query: 2371 SRAQARAE---EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2427
             +AQA  E   +   R   +AE++        LA  E      TL               
Sbjct: 1160 QKAQAEVEGLGKGVARLSAEAEKV--------LALPEPSPAAPTLR-------------- 1197

Query: 2428 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF- 2486
               +ELE    KL+Q   L  +  E+++T+    +++ TQ  ++   + ++ L + +   
Sbjct: 1198 ---SELELTLGKLEQVRSLSAIYLEKLKTISL--VIRGTQGAEEVLRAHEEQLKEAQAVP 1252

Query: 2487 -----IEQEKAKLEQLFQDEVAKAQQ-----LREEQQRQQQQMEQERQRLVASMEEARRR 2536
                 +E  KA L++L     A+AQQ     LR+E +  Q+  E+ +QR      E  R 
Sbjct: 1253 ATLPELEATKASLKKLRAQ--AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1310

Query: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEEL 2564
            +    + + R Q  L Q + ++R+ E+L
Sbjct: 1311 RERVAQLLERWQAVLAQTDVRQRELEQL 1338



 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 207/973 (21%), Positives = 381/973 (39%), Gaps = 145/973 (14%)

Query: 1505 AAREKQRALQALEELR------LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQS 1558
            AA E++R   + EE+       L+ +E E   ++A+  R++ +  +LE A ++ + ++  
Sbjct: 433  AAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPP 492

Query: 1559 KRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618
                       +E+   + HVA+       ER  Q ++E ER             L+  +
Sbjct: 493  -----GYHPLDVEKEWGKLHVAIL------EREKQLRSEFER-------------LECLQ 528

Query: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKE----EAEREARRRGKAEEQAVRQRELAEQELEK 1674
             +  +LQ E    ++ L QA+A  Q +     A +  +R G+ E    +   +       
Sbjct: 529  RIVTKLQMEAGLCEEQLHQADALLQSDIRLLAAGKVPQRAGEVERDLDKADSMIRLLFND 588

Query: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1734
             + L +G   Q     + + RL       E+   +  E   RL+   AA   +  ++  +
Sbjct: 589  VQTLKDGRHPQGEQMYRRVYRLH------ERLVAIRTEYNLRLKAGVAAPATQVAQVTLQ 642

Query: 1735 LAKVRAEMEVLLASKARAEEESRSTSEKSKQRL------------EAEAGRFRELAEEAA 1782
              + R E+E    S  R  ++  +  E+++ R+            EA+ G  R L +   
Sbjct: 643  SVQRRPELE---DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE 699

Query: 1783 RLRALAEEAKRQR-QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAEN 1841
              +A  E A+    QL+       R    R+  +         +L   ++  L+  E+ +
Sbjct: 700  EFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQY-------AKLLNSSKARLRSLESLH 752

Query: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
              +    ++  +   + EE+     +D    +   +K S S L R+  L E  +++ +  
Sbjct: 753  SFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA-KKESYSALMRELELKEKKIKELQNA 811

Query: 1902 EEEILA-------LKASFEKAAAGKAELELEL-----GRIRSNAEDTLRSKEQAELEAAR 1949
             + +L           SF+ A   +    L+L       ++ NA       +  E E   
Sbjct: 812  GDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQL 871

Query: 1950 QRQLAAEEERRRREAEERVQKSLAAEE--EAARQRKAALEEVE-RLKAKVEEARRLRERA 2006
            Q+    +E  RR+ + +R       E+  + A+  K  L E +  L    + A+ + +  
Sbjct: 872  QK---LQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928

Query: 2007 EQESARQLQ--LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064
             +  A  ++  L   A     Q E   H      K  E Q     + S    L      A
Sbjct: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVH------KGDECQLVGPAQPSHWKVLSSSGSEA 982

Query: 2065 RRAA---------EEAEEA--RVQAEREAAQS---RRQVEEAERLK-QSAEEQAQA-RAQ 2108
               +         +E +EA  R++A+ +A  +   +  V+    L  QS     Q  R+ 
Sbjct: 983  AVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 1042

Query: 2109 AQAAAEKLRKEAEQEAARRAQAE-QAALRQKQAADAEMEKHKKFAE-------------- 2153
            + A    L+ E +++A    +   QA LR  Q A     + +  AE              
Sbjct: 1043 SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLL 1102

Query: 2154 QTLRQKAQVEQ-------ELTTLRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVE 2205
            Q+L Q AQ E        EL  +RLQLE  + +       + RL+     E AR+ +Q  
Sbjct: 1103 QSLEQGAQEESRCQRCISELKDIRLQLEACETRT------VHRLRLPLDKEPARECAQRI 1156

Query: 2206 EELFSVRVQMEELSKLKARIEAE-NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA 2264
             E    + ++E L K  AR+ AE  + L L +       L+ E E      E+   LS  
Sbjct: 1157 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1216

Query: 2265 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2324
              E  +   L    + +    AE++L+   + ++EA  + A    L+  K  + ++ R  
Sbjct: 1217 YLEKLKTISL----VIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA-SLKKLRAQ 1271

Query: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE-MSRAQA-RAEEDAQ 2382
             E ++     L +E +G Q   E  +QR  E   E ER + RVA+ + R QA  A+ D +
Sbjct: 1272 AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVR 1331

Query: 2383 RFRKQAEEIGEKL 2395
              +++ E++G +L
Sbjct: 1332 --QRELEQLGRQL 1342



 Score = 62.0 bits (149), Expect = 1e-08
 Identities = 164/754 (21%), Positives = 286/754 (37%), Gaps = 154/754 (20%)

Query: 1169 VLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQ 1228
            V  Q+  R+ ELE     LRY ++    L AW+++ + R +  +     D  +V  QL  
Sbjct: 639  VTLQSVQRRPELED--STLRYLQD----LLAWVEENQHRVDGAEWG--VDLPSVEAQLGS 690

Query: 1229 EQALLEEIERHGEKVEECQRFAKQYINAIK------------DYELQLVTYKAQLEPVAS 1276
             + L + IE    K+E  +    Q   A +             Y   L + KA+L  + S
Sbjct: 691  HRGLHQSIEEFQAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750

Query: 1277 PAKKPKVQSGSESVI----QEYVDLRTHYSELTTLTSQYIKFISETLRRME-EEERLAEQ 1331
                  V + ++ ++    +E  ++   +S+  T  +   +  S  +R +E +E+++ E 
Sbjct: 751  --LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKEL 808

Query: 1332 QRAEER---------ERLAEVEAALEKQ----RQLA---EAHAQAKA----------QAE 1365
            Q A +R           +   +AAL+ Q     QL    EAH +  A          +AE
Sbjct: 809  QNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAE 868

Query: 1366 REAKELQQRMQEE--------VVRREEAAVDAQQQKRSIQE---ELQQLRQSSEAEIQAK 1414
             + ++LQ+ ++ +        V R E+   DAQ +K  + E    L  L + ++A +Q K
Sbjct: 869  GQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLK 928

Query: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQ-----ALRARAEEAEAQK-- 1467
             R      R RL +       ++++   +       G  Q      L +   EA      
Sbjct: 929  PRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVC 988

Query: 1468 -------RQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520
                   ++ QE   RL  Q Q       Q  V++ S +     A +  +R +Q +    
Sbjct: 989  FLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLL-----AWQSLRRDVQLIRSWS 1043

Query: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA 1580
            L         R  + E  RQ   +LE   ++   + Q       E     ER        
Sbjct: 1044 LAT------FRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHH 1097

Query: 1581 VAQLREEAERRAQQQAEAERAREEAER---ELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637
              QL +  E+ AQ+++  +R   E +    +LE  + +    LRL L  E     +  AQ
Sbjct: 1098 YQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA---RECAQ 1154

Query: 1638 AEAEKQKEEAEREARRRG----KAEEQAV--------------RQRELAEQELEKQRQLA 1679
              AE+QK +AE E   +G     AE + V               + EL   +LE+ R L+
Sbjct: 1155 RIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLS 1214

Query: 1680 --------------EGT--AQQRLAAEQE---------------------LIRLRAETEQ 1702
                           GT  A++ L A +E                     L +LRA+ E 
Sbjct: 1215 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1274

Query: 1703 GEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK 1762
             +     L +EL   Q       Q+  E + E+ + R  +  LL       +   + ++ 
Sbjct: 1275 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL----ERWQAVLAQTDV 1330

Query: 1763 SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ 1796
             ++ LE    + R   E A  L A  ++A+R+++
Sbjct: 1331 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1364



 Score = 60.8 bits (146), Expect = 3e-08
 Identities = 162/760 (21%), Positives = 291/760 (38%), Gaps = 123/760 (16%)

Query: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLE----QVRSLSAIYLEKLKT 1068
            GL + +    A+ E+  A  +    +P  R      LG+L+    ++ + S   L  L++
Sbjct: 693  GLHQSIEEFQAKIER--ARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES 750

Query: 1069 I-SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDAL 1127
            + S V   T+    +    EE++    +   T   + A K S   L  + E ++      
Sbjct: 751  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNT--NMTAKKESYSALMRELELKEK----- 803

Query: 1128 RDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQL 1187
              +++  Q  G+RL +        VE ++   A L  +W  +L      +  L++     
Sbjct: 804  --KIKELQNAGDRLLREDHPARPTVESFQ---AALQTQWSWMLQLCCCIEAHLKENAAYF 858

Query: 1188 RYYRESADPLGAW--LQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIE 1237
            +++ +  +  G    LQ+A RR+               L D+Q  +EQL + +  L  + 
Sbjct: 859  QFFSDVREAEGQLQKLQEALRRKNSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLA 918

Query: 1238 RHGEKVEECQRFAKQY-------INAIKDY-ELQLVTYKAQLEPVASPAK----KPKVQS 1285
            +  + V + +     +       + A+ DY ++++  +K     +  PA+    K    S
Sbjct: 919  KRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSS 978

Query: 1286 GSESVIQEYVDL-----RTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
            GSE+ +     L     +     +T L +Q+   ++   +   + + L   Q      +L
Sbjct: 979  GSEAAVPSVCFLVPPPNQEVQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQL 1038

Query: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL 1400
                +    +    E   QA    E   +   +  Q+      E  + A+++  S     
Sbjct: 1039 IRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHY 1098

Query: 1401 QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARA 1460
            QQL QS E   Q ++R          R   E++ +RLQLEA E +       +  LR   
Sbjct: 1099 QQLLQSLEQGAQEESRCQ--------RCISELKDIRLQLEACETRT------VHRLRLPL 1144

Query: 1461 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ----AL 1516
            +     K  A+E A+R+  Q      +K QAEVE   +  A   A  EK  AL     A 
Sbjct: 1145 D-----KEPARECAQRIAEQ------QKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAA 1193

Query: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576
              LR + E    +L Q                       ++S  A + EK   +   ++ 
Sbjct: 1194 PTLRSELELTLGKLEQ-----------------------VRSLSAIYLEKLKTISLVIRG 1230

Query: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL- 1635
               A   LR   E+  + QA      E          L+A +A   +L+A+  AQQ +  
Sbjct: 1231 TQGAEEVLRAHEEQLKEAQAVPATLPE----------LEATKASLKKLRAQAEAQQPTFD 1280

Query: 1636 -AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK-QRQLAEGTAQQRLAAEQEL 1693
              + E    +E  ER  +R G+ + +  R RE   Q LE+ Q  LA+   +QR       
Sbjct: 1281 ALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQR------- 1333

Query: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEA 1733
                 E EQ  +Q +   E    L      A +++++++A
Sbjct: 1334 -----ELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1368


>gi|33188445 microfilament and actin filament cross-linker protein
            isoform a [Homo sapiens]
          Length = 5430

 Score = 1379 bits (3569), Expect = 0.0
 Identities = 924/2804 (32%), Positives = 1489/2804 (53%), Gaps = 249/2804 (8%)

Query: 1    MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
            +DP+   +  +  + DERDRVQKKTFTKWVNKHL+K ++HI+DLYEDLRDGHNLISLLEV
Sbjct: 62   LDPA---ERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEV 118

Query: 61   LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
            LSG  LPREKGRMRFH+LQNVQIALD+L+ RQVKLVNIRNDDI DGNPKLTLGLIWTIIL
Sbjct: 119  LSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIIL 178

Query: 121  HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
            HFQISDI +SG+S DM+AKEKLLLW+Q++  GY G++C NF+S W DG++FNA+IHR++P
Sbjct: 179  HFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRP 238

Query: 181  LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
             L+DM +V  Q+N ENL+QAF VAER LGVTRLLD EDVDVP PDEKS+ITYVSS+YDA 
Sbjct: 239  DLVDMERVQIQSNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAF 297

Query: 241  PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
            P+VP+  +G+ A E+  RWQEY+  V  L+ W++ HT    ++ FP +  E++ L++Q++
Sbjct: 298  PKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYI 357

Query: 301  KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
             FKE E+ AKE +K R + +Y+ LE  ++ G++K+P GYHP DVE+EWGKL + +LEREK
Sbjct: 358  HFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREK 417

Query: 361  QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
             LR   ERLE L +I  K+Q  A  CEE+L  A   LQ+D   L +G+  Q   +V   +
Sbjct: 418  SLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYI 477

Query: 421  DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAG------- 473
             + + +IR L  D+Q L+D  + Q E++  RV RL + LV +R E     + G       
Sbjct: 478  QECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLEL 537

Query: 474  -----------VAAPATQVAQVTLQSVQRRP----EL-------EDSTLRYLQDLLAWVE 511
                        A P T+    +  S  R+P    EL       ++  LR++ +LL+WVE
Sbjct: 538  VPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVE 597

Query: 512  ENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDC 571
            E Q +++ AEWG DLPSVE QL + + +H S+EE  + ++ AR  EG++S     +Y + 
Sbjct: 598  EMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAET 657

Query: 572  LGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTA 631
            LG+L+ QY KL  +S  R+R L+SLH FV+ AT EL+WLNEKEEEE+ +DWSD N+N++A
Sbjct: 658  LGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISA 717

Query: 632  KKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCC 691
            K+  +S L  ELE K+   + LQ+  + L  E+HPA+ TVE++ AA+Q+Q  WM QLC C
Sbjct: 718  KRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLC 777

Query: 692  IEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ 751
            +E H+KEN AYFQFFSD RE E  L+ LQ++++RKYSCD + +++RLEDLLQD+ DEKEQ
Sbjct: 778  VEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQ 837

Query: 752  LNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGP 811
            L + K  ++ L  R+K +VQLKPR P H ++  + + AVCDY+Q+E+T+ K DEC L   
Sbjct: 838  LIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDN 897

Query: 812  AQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSL 871
            +Q + WKV+S +G+EA VPSVCFL+PPPN++A E  +R+E  +Q ++ LWHQLHV+ KSL
Sbjct: 898  SQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSL 957

Query: 872  LAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 931
            ++W  LR+D+ L+++W+L   R+  P E  Q + +L+ HY+ FL+DS+D+  F   DRL 
Sbjct: 958  ISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLR 1017

Query: 932  AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLR----L 987
             E E  +C   +Q L++S+E   +EE+  +  ISELK+IRL+LE  E R V R++     
Sbjct: 1018 LEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASS 1077

Query: 988  PLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELEL 1047
              D++  ++ A RIAEQ+  Q +++ L   +  +S + +  L     S + PTLRSEL L
Sbjct: 1078 RTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNL 1137

Query: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATK 1107
             + K++ V  LS +YL KLKT+ +++R  Q AE +++ +E +L + + V A L  LEA  
Sbjct: 1138 LVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHW 1197

Query: 1108 ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167
            ++L+   +  + +   F  L +E+  A+ V E++ +   ER++++ER++E+ +QL ERW 
Sbjct: 1198 STLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWH 1257

Query: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1227
             V+AQ ++RQ ELE +   L  YR     L  W+++   +QE ++     DS+ + EQL 
Sbjct: 1258 RVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLS 1317

Query: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PVASPAKKPKVQSG 1286
            Q+ AL  EIER+  K+++CQ+F++QY   +KDYELQL+TYKA +E    SP K+ ++ S 
Sbjct: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377

Query: 1287 SESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEV--- 1343
            S+++ QE++DLRT Y+ L TLT+Q++K+IS+ LRR+EEEE++ E+++ E  E++ E+   
Sbjct: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437

Query: 1344 EAALEKQRQLAEAHAQAKAQAEREAKELQQR-MQEEVVRREEAAVDA------------- 1389
             + L +  Q     ++ K   + E   L+Q+ + EE+  ++E   +A             
Sbjct: 1438 VSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGH 1497

Query: 1390 ---QQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQR 1446
               +++K+ I E+L  L ++        A Q +  + S+L  + E + ++ Q     +Q 
Sbjct: 1498 KLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ-SQLAHQTEQKTLQKQQNTCHQQL 1556

Query: 1447 GGAEGELQALRARAEEAEA--QKRQAQEEAERLR------RQVQDESQRKRQAEVELASR 1498
                 +L +   +AE A A  Q R  Q++   L+      + +QD+ Q +  +   +   
Sbjct: 1557 ----EDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKD 1612

Query: 1499 VKAEAEAAREK--QRALQALEELRLQAEE------AERRLRQAEVERARQVQVALETAQR 1550
            ++   E  + K   R L AL E   QA+E       E R+ Q E+E A    +  ET + 
Sbjct: 1613 IEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKS 1672

Query: 1551 SAEAELQSKR----------ASFAEKTAQLERSLQ-EEHVAVAQLREEAERRAQQQAEAE 1599
             A  EL   +           S      QL  +L   E ++ A L + A           
Sbjct: 1673 KAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVN 1732

Query: 1600 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEE 1659
            +A E+ +++ E  + +  E L    Q +        AQA  ++               EE
Sbjct: 1733 QAPEKLDKQCEMMKARHQELLS---QQQNFILATQSAQAFLDQHGHNL--------TPEE 1781

Query: 1660 QAVRQRELAEQELEKQRQLAEGTAQ--QRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
            Q + Q++L E + +    LA+  A+  Q    + EL +   + ++ E   +  E+EL  +
Sbjct: 1782 QQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENM 1841

Query: 1718 QR-----EAAAATQKRQ-ELEAELAKVRAEMEVLLASKARAEEESRSTSEKS-------- 1763
             +     E   +  KRQ     ++   + ++  +  S  +  +   S  E          
Sbjct: 1842 HKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNL 1901

Query: 1764 -KQRLEAEAGRFRELAEEAARLRA-----LAEEAKRQRQLAEEDAARQRAEA--ERVLAE 1815
             K +L+    R+  L  +  RL +     L +  + Q       A  Q  EA  E++L++
Sbjct: 1902 VKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSD 1961

Query: 1816 KLAA----IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871
             +A+    + E      + +  L E +   E+L+++A D       +E + A     ++E
Sbjct: 1962 TVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD----IMEIEGEPAPDHRHVQE 2017

Query: 1872 R----LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASF---EKAAAGKAELEL 1924
                 L+  +  S S  ER   L++  + Q + V+E + +L  S    E+   GK    L
Sbjct: 2018 TTDSILSHFQSLSYSLAER-SSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSL 2076

Query: 1925 ELGRIRSNAEDTLR-----SKEQAELEAARQ----------RQLAAEEERRRREAEERVQ 1969
              G I+      ++     +++++ LEA R+             AA  + +  E  +R +
Sbjct: 2077 SSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE 2136

Query: 1970 KSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
            +    ++E     K  L + E  +    + ++  E   +  A   Q  Q+      Q +E
Sbjct: 2137 QLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQE 2196

Query: 2030 KAHAFAVQQKEQELQQTLQQEQSV------LDQLRGEAEAARRAAEEAEEARVQAEREAA 2083
                   QQ+  +  + L  E S       L Q +   +  R+   E ++   + E++A+
Sbjct: 2197 LNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDAS 2256

Query: 2084 QSRRQVEEAERLKQSAE-------------EQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130
              + Q++E  +L ++ +             E + +  + +   E L+   +  A++    
Sbjct: 2257 SCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLV 2316

Query: 2131 EQAALRQKQAADAEMEKHKKFAE--------------------QTLRQKAQVEQELTTLR 2170
            E+   +     +  ME     ++                     T +   +++ +++ + 
Sbjct: 2317 EEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVN 2376

Query: 2171 LQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENR 2230
            L+ E+     +   E LQ +     E  ++ + V + L S    ++ +  + +  + E  
Sbjct: 2377 LKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETV 2436

Query: 2231 ALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVA---AQEAARLRQLAEEDLAQQRALAE 2287
                         L++ + K+++V E  A L V    +QEA   +++ EE  ++     E
Sbjct: 2437 KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE 2496

Query: 2288 KMLKEKMQAVQEATRL----KAEAELLQ--QQKELAQEQARRLQEDKEQMAQQLAEETQG 2341
              +  + Q  + A+ L     AE++L     +KEL       L  D   +  Q  ++ Q 
Sbjct: 2497 VTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQ-KQQVQF 2555

Query: 2342 FQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLH-RTEL 2400
              +  EA RQ+  +++  A+ +     ++S + ++ +++ Q   ++  E+ +KL+ R+  
Sbjct: 2556 MLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQVQKELQSINQKWVELTDKLNSRSSQ 2615

Query: 2401 ATQ----------------EKVTLV-QTLEIQRQQSDHD--AERLREAIAELEREKEKLQ 2441
              Q                EKV  V Q L +Q   S      ++  E  +E+  + E+L 
Sbjct: 2616 IDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLD 2675

Query: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDE 2501
             E K  Q   +E+  +  EQ L             KD L +R   +      LE L  D 
Sbjct: 2676 HEVKEAQTLCDELSVLIGEQYL-------------KDELKKRLETVALPLQGLEDLAADR 2722

Query: 2502 VAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR-----QHEAEEGVRRKQEELQQLEQ 2556
            + + Q      Q+ QQ  ++ R  L     +  +      + E  +   ++ EE Q+   
Sbjct: 2723 INRLQAALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQLQENEEFQKSLN 2782

Query: 2557 QRRQQEELLAEENQRL------REQLQLLEEQHRAALAHSEEVT 2594
            Q     E++  E + L       E+ + L+ Q      H EE++
Sbjct: 2783 QHSGSYEVIVAEGESLLLSVPPGEEKRTLQNQLVELKNHWEELS 2826



 Score =  131 bits (329), Expect = 2e-29
 Identities = 322/1752 (18%), Positives = 693/1752 (39%), Gaps = 241/1752 (13%)

Query: 992  EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGK 1051
            E  R   QR++ Q     + E + + +   S     +  L      A TL  EL + +G+
Sbjct: 2635 EKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRSDLEQLDHEVKEAQTLCDELSVLIGE 2694

Query: 1052 LEQVRSLSAIYLEKLKTISLVIRGTQG-AEEVLRAHEEQLKEAQAVPATLPELEATKASL 1110
                + L     ++L+T++L ++G +  A + +   +  L   Q       EL       
Sbjct: 2695 ----QYLKDELKKRLETVALPLQGLEDLAADRINRLQAALASTQQFQQMFDELRTWLDDK 2750

Query: 1111 KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV----------------EVER 1154
            +  +A+        + L+ +L+  +E  + L Q  G  +V                E   
Sbjct: 2751 QSQQAKNCPISAKLERLQSQLQENEEFQKSLNQHSGSYEVIVAEGESLLLSVPPGEEKRT 2810

Query: 1155 WRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAM 1214
             + ++ +L   W+ +  +T  RQ  L+   ++ + Y+   + L  W++D + +  +++  
Sbjct: 2811 LQNQLVELKNHWEELSKKTADRQSRLKDCMQKAQKYQWHVEDLVPWIEDCKAKMSELRV- 2869

Query: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL-EP 1273
               D   +   L + +A+L E+E+    +E     A   IN+ +  E  +   KA + + 
Sbjct: 2870 -TLDPVQLESSLLRSKAMLNEVEKRRSLLEILNSAADILINSSEADEDGIRDEKAGINQN 2928

Query: 1274 VASPAKKPKVQSGS-ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQ- 1331
            + +  ++ + ++GS E + Q   + +  +  +        K +     ++E  + L  Q 
Sbjct: 2929 MDAVTEELQAKTGSLEEMTQRLREFQESFKNIE-------KKVEGAKHQLEIFDALGSQA 2981

Query: 1332 ---QRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-----------------AEREAKEL 1371
               +  E+     EV  ALE Q        Q   +                 A++E  E+
Sbjct: 2982 CSNKNLEKLRAQQEVLQALEPQVDYLRNFTQGLVEDAPDGSDASQLLHQAEVAQQEFLEV 3041

Query: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE- 1430
            +QR+    V  E       Q    ++E   QL    + E+          +  + +IE+ 
Sbjct: 3042 KQRVNSGCVMMENKLEGIGQFHCRVREMFSQLADLDD-ELDGMGAIGRDTDSLQSQIEDV 3100

Query: 1431 -----EIRVVRLQLEATE-------RQRG-----GAEGELQALRARAEEAEAQKRQAQEE 1473
                 +I V++L +EA+E        + G     G + EL+AL  +  +   + +  QE+
Sbjct: 3101 RLFLNKIHVLKLDIEASEAECRHMLEEEGTLDLLGLKRELEALNKQCGKLTERGKARQEQ 3160

Query: 1474 AERLRRQVQDESQRKRQAEVELASRVKAEA---EAAREKQRALQALEELRL----QAEEA 1526
             E    +V+D  ++ +       +  +AEA       E +   Q L + ++    Q +  
Sbjct: 3161 LELTLGRVEDFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQLADFKMFQKEQVDPL 3220

Query: 1527 ERRLRQAEVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAV 1581
            + +L+Q        +Q A     ++  +   E E+ ++  +  +K AQ    LQE  +  
Sbjct: 3221 QMKLQQVNGLGQGLIQSAGKDCDVQGLEHDME-EINARWNTLNKKVAQRIAQLQEALLHC 3279

Query: 1582 AQLREEAERRAQQQAEAE-----RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
             + ++  E      A+ E     +    AE ++ + Q++  + L+  L   +      + 
Sbjct: 3280 GKFQDALEPLLSWLADTEELIANQKPPSAEYKVVKAQIQEQKLLQRLLDDRKAT--VDML 3337

Query: 1637 QAEAEKQKEEAEREARRR--GKAEEQAVRQRELAEQELEKQRQLAE--GTAQQRLAAEQE 1692
            QAE  +  + AE   R +  G+ E    R  EL  +   +Q+QL +    A+Q     + 
Sbjct: 3338 QAEGGRIAQSAELADREKITGQLESLESRWTELLSKAAARQKQLEDILVLAKQFHETAEP 3397

Query: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752
            +    + TE+     + +  + A++Q++        +++E     V   +++    ++ +
Sbjct: 3398 ISDFLSVTEKKLANSEPVGTQTAKIQQQIIRHKALEEDIENHATDVHQAVKI---GQSLS 3454

Query: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV 1812
               S +      +++++   R+ E+ +   R  AL ++A    +L  ED           
Sbjct: 3455 SLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALSNARLFGED----------- 3503

Query: 1813 LAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER 1872
                            E E+     E E++      +D  F++  L  Q A H A + E 
Sbjct: 3504 ----------------EVEVLNWLAEVEDKLSSVFVKD--FKQDVLHRQHADHLA-LNEE 3544

Query: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
            +   +K  D  ++  + L++ T        EE+L ++   +      A++ +        
Sbjct: 3545 IVNRKKNVDQAIKNGQALLKQT------TGEEVLLIQEKLDGIKTRYADITV-------T 3591

Query: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERL 1992
            +   LR+ EQA   A + +    E     RE EE +  S   +     Q     +  + L
Sbjct: 3592 SSKALRTLEQARQLATKFQSTYEELTGWLREVEEELATS-GGQSPTGEQIPQFQQRQKEL 3650

Query: 1993 KAKVEEARRLRERAEQESARQLQL----AQEAAQKRLQAEEKAHAFA-------VQQKEQ 2041
            K +V E R + +   + S   L+L    A+E   K +    + +          V + + 
Sbjct: 3651 KKEVMEHRLVLDTVNEVSRALLELVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDA 3710

Query: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-----ERLK 2096
             +Q++ Q EQ+   +L   AE  R+         ++ E++   ++ QV++A      R K
Sbjct: 3711 AIQRSQQYEQAADAELAWVAETKRKLMALGP---IRLEQDQTTAQLQVQKAFSIDIIRHK 3767

Query: 2097 QSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTL 2156
             S +E    R++      + +K   QE        ++ ++Q +A    +   +++A    
Sbjct: 3768 DSMDELFSHRSEIFGTCGEEQKTVLQEKT------ESLIQQYEA--ISLLNSERYAR--- 3816

Query: 2157 RQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQME 2216
             ++AQV      L  Q  ET  + +   EE + L A+    A    Q+ ++   +R   E
Sbjct: 3817 LERAQV------LVNQFWETYEELSPWIEETRALIAQLPSPAIDHEQLRQQQEEMRQLRE 3870

Query: 2217 ELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLA- 2275
             +++ K  I+      +L+     +    EE E +++  ++A  +    +E  R R LA 
Sbjct: 3871 SIAEHKPHIDK-----LLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRALAL 3925

Query: 2276 EEDLAQQRALAE-----KMLKEKMQAVQEATR----LKAEAELLQQ---QKELAQEQARR 2323
            +E ++Q   + E     + + E ++ +    R    + AE + +++     + A  +  +
Sbjct: 3926 DEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLIPAEVDKIRECISDNKSATVELEK 3985

Query: 2324 LQ---EDKEQMAQQLAEETQGFQRTLEA-ERQRQL--------EMSAEAERLKLRVAEMS 2371
            LQ   E  ++  ++L   +QG  + L A E Q +L        ++ A AE  +++  ++ 
Sbjct: 3986 LQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEEREIKFLDVL 4045

Query: 2372 RAQARAEEDAQRFRKQAEEIGEKLHRTE------LATQEKVTLVQTLEIQRQQSDHDAER 2425
                +   D        ++  + +H  E         +++V   +T++ +      + E 
Sbjct: 4046 ELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSIIKQQVEAAETIKEETDGLHEELEF 4105

Query: 2426 LREAIAEL-----EREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL 2480
            +R   A+L     E EK ++++    +    E +    +E+ L++ +   Q+ +  +D+L
Sbjct: 4106 IRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKTWKER-LEKLEDAMQAAVQYQDTL 4164

Query: 2481 LQRERFIEQEKAKLEQL---------FQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
                 +++    KL  +          +D++ + ++ + E  +QQ +ME+   +    ++
Sbjct: 4165 QAMFDWLDNTVIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQQQIEMEKLNHQGELMLK 4224

Query: 2532 EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLR------EQLQLLEEQHRA 2585
            +A     E +  + R  E L +L+       E +A    +L        Q Q   E+  +
Sbjct: 4225 KA---TDETDRDIIR--EPLTELKHLWENLGEKIAHRQHKLEGALLALGQFQHALEELMS 4279

Query: 2586 ALAHSEEVTASQ 2597
             L H+EE+  +Q
Sbjct: 4280 WLTHTEELLDAQ 4291



 Score =  129 bits (325), Expect = 5e-29
 Identities = 545/2630 (20%), Positives = 996/2630 (37%), Gaps = 398/2630 (15%)

Query: 184  DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 243
            D N V+   + E + +A  VAE+   ++RL    ++D+ +  EK      S L +   RV
Sbjct: 1209 DKNSVFSVLD-EEIAKAKVVAEQ---MSRLTPERNLDLERYQEKG-----SQLQERWHRV 1259

Query: 244  PDVQDGVRANELQLRWQ---EYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
               Q  +R +EL+   +   +YR     L++W+   TA  +E   P   E+  +L  Q  
Sbjct: 1260 I-AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQ-QEMMKPGQAEDSRVLSEQLS 1317

Query: 301  KFKEM--ELPAKEADKNRSKGIYQSLEGAVQAGQLKV------------PPGYHP----- 341
            +   +  E+   +   ++ +   Q     V+  +L++             PG        
Sbjct: 1318 QQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSS 1377

Query: 342  --------LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQME-AGLCEEQLNQ 392
                    +D+   +  L     +  K +     RLE  +++V + + E     +E L  
Sbjct: 1378 SDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGW 1437

Query: 393  ADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKD------------- 439
               L ++       GK      +   D++KA    ++L  ++ T K+             
Sbjct: 1438 VSTLARN-----TQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFL 1492

Query: 440  GRHPQGEQMYRRVYR-LHERLVAIRTEYNLRLKAGVAAPATQV-AQVTLQSVQRRPELED 497
             +H  G ++  +  + + E+L A+   Y+  L  G A    Q+ +Q+  Q+ Q+  + + 
Sbjct: 1493 AKH--GHKLSEKEKKQISEQLNALNKAYH-DLCDGSANQLQQLQSQLAHQTEQKTLQKQQ 1549

Query: 498  STL-RYLQDLLAWVEENQHRVDGAEWGV---DLPSVEAQLGSHRGLHQSIEEFRAKIERA 553
            +T  + L+DL +WV + +  + G +      DL +++      + L   I+         
Sbjct: 1550 NTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATV 1609

Query: 554  RSD--------EGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFV----- 600
              D        + +LSP    A R+ L +   QY  L   ++   + LE   +       
Sbjct: 1610 VKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQET 1669

Query: 601  --AAATKELMWLNEKEEE------EVGFDWSDRNTNMTAKKESYSALMRELELKEKK-IK 651
              + A KEL    +K +        VG       TN+   ++   A + +  L       
Sbjct: 1670 EKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYM 1729

Query: 652  ELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVRE 711
             +  A ++L   D          Q  L  Q +++L       A     A   Q   ++  
Sbjct: 1730 GVNQAPEKL---DKQCEMMKARHQELLSQQQNFIL-------ATQSAQAFLDQHGHNLTP 1779

Query: 712  AEGQL--QKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQ-LNEYKGHLSGLAKRAKA 768
             E Q+  QKL E L+ +YS   + +   L+ + Q  QDE ++ L ++K   S L +  K 
Sbjct: 1780 EEQQMLQQKLGE-LKEQYSTSLAQSEAELKQV-QTLQDELQKFLQDHKEFESWLERSEK- 1836

Query: 769  VVQLKPRHPAHPMRGRLP-LLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGS-- 825
              +L+  H        LP LL        +V  HKGD   +    Q    KVL    S  
Sbjct: 1837 --ELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQ----KVLDMENSFK 1890

Query: 826  EAAVPS-VCFLVPPPNQEAQEAVT-------RLEAQHQALVTLWHQLHVDMKSLLAW-QS 876
            E   PS +  LV    ++A E  T       RL +    L+  +HQ      SL AW Q+
Sbjct: 1891 EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQA 1950

Query: 877  LRRDVQLIRSWSLAT--------FRTLKPEEQRQALHSLELH-YQAFLRDSQDAGGFGPE 927
               +V+ + S ++A+          T K  ++  A H + +   Q   RD  +  G    
Sbjct: 1951 CEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAP 2010

Query: 928  DRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRL 987
            D    +    S   H+Q L  SL   A+  S  Q+ I++ + ++  LE+   +++  +  
Sbjct: 2011 DHRHVQETTDSILSHFQSLSYSL---AERSSLLQKAIAQSQSVQESLESL-LQSIGEVEQ 2066

Query: 988  PLDKEPARECAQRIAEQQKAQAEVEGLGKGVAR----LSAEAEKVLALPEP--SPAAPTL 1041
             L+ +     +  +   Q+A A    L + +AR    L A  E V    E   S  A  L
Sbjct: 2067 NLEGKQVSSLSSGVI--QEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVL 2124

Query: 1042 RSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPAT-- 1099
            + +L     + EQ   L     EK  ++  ++   +  E +    ++ ++    + A+  
Sbjct: 2125 QGKLAEVSQRFEQ---LCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGN 2181

Query: 1100 LPELEATK--ASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157
             P+ + T     +++L  + E QQ   D L   +      G  L         ++ + ++
Sbjct: 2182 QPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFAL---------DLCQHQD 2232

Query: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLA 1217
            RV  L + +  +      R+++      QL  +R+       WL++        +    A
Sbjct: 2233 RVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSA 2292

Query: 1218 DSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP 1277
              + + +Q+   ++LL++    G  VEE         N I +     +T         S 
Sbjct: 2293 --KELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIME-----ITAPDSQGKTGSI 2345

Query: 1278 AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEER 1337
                    GS +      DL     +++ +  +Y K       R E  + +  +     +
Sbjct: 2346 LPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHK 2405

Query: 1338 ERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ 1397
            E  + ++    K+  L    A +        K   +  +  +   E+ +   Q+ K ++ 
Sbjct: 2406 EANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALA 2465

Query: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALR 1457
              L     S EAE   K ++                                  EL +  
Sbjct: 2466 GLLVTYPNSQEAENWKKIQE----------------------------------ELNSRW 2491

Query: 1458 ARAEEAE-AQKRQAQEEAERLRRQVQDESQ-RKRQAEVELASRVKAEAEAAREKQRALQA 1515
             RA E   A++RQ +E A  L      ESQ R    E EL   V            A + 
Sbjct: 2492 ERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQ 2551

Query: 1516 LEELRLQAEEAERRLRQAEVERARQV-----QVALETAQRSAEAELQSKRASFAEKTAQL 1570
              +  L+  EA R+  +   E A+ +      V+L T+Q   + ELQS    + E T +L
Sbjct: 2552 QVQFMLKEFEARRQQHEQLNEAAQGILTGPGDVSLSTSQ--VQKELQSINQKWVELTDKL 2609

Query: 1571 E-RSLQEEHVAVAQ------LREEAER-RAQQQAEAERAREEAERELERWQLKANEALRL 1622
              RS Q +   V        L++ +E+ RA  Q  + ++    + E  + QL+    +R 
Sbjct: 2610 NSRSSQIDQAIVKSTQYQELLQDLSEKVRAVGQRLSVQSAISTQPEAVKQQLEETSEIRS 2669

Query: 1623 RLQA--EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE 1680
             L+    EV + ++L    +    E+  ++  ++ + E  A+  + L +   ++  +L  
Sbjct: 2670 DLEQLDHEVKEAQTLCDELSVLIGEQYLKDELKK-RLETVALPLQGLEDLAADRINRLQA 2728

Query: 1681 GTAQ-QRLAAEQELIRLRAETEQGEQQRQL-LEEELARLQREAAAATQKRQELEAELAKV 1738
              A  Q+     + +R   + +Q +Q +   +  +L RLQ +     Q+ +E +  L + 
Sbjct: 2729 ALASTQQFQQMFDELRTWLDDKQSQQAKNCPISAKLERLQSQL----QENEEFQKSLNQH 2784

Query: 1739 RAEMEVLLASKARAEEESRSTSE---KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQR 1795
                EV++A     E ES   S    + K+ L+ +    +   EE ++     + A RQ 
Sbjct: 2785 SGSYEVIVA-----EGESLLLSVPPGEEKRTLQNQLVELKNHWEELSK-----KTADRQS 2834

Query: 1796 QLAEEDAARQRAEAERVLAEKLAAIGEATRLK-TEAEIALKEKEAENERLRRLAEDEAFQ 1854
            +L +     Q+A+  +   E L    E  + K +E  + L   + E+  LR  A     +
Sbjct: 2835 RLKD---CMQKAQKYQWHVEDLVPWIEDCKAKMSELRVTLDPVQLESSLLRSKAMLNEVE 2891

Query: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1914
            +RR   +     ADI   L    +A +  +  +K  +   +     V EE+ A   S E+
Sbjct: 2892 KRRSLLEILNSAADI---LINSSEADEDGIRDEKAGINQNMDA---VTEELQAKTGSLEE 2945

Query: 1915 AAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
                  E +     I    E    +K Q E+  A   Q  + +   +  A++ V ++L  
Sbjct: 2946 MTQRLREFQESFKNIEKKVEG---AKHQLEIFDALGSQACSNKNLEKLRAQQEVLQALEP 3002

Query: 1975 EEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAF 2034
            + +  R     L E         +A +L  +AE      L++ Q      +  E K    
Sbjct: 3003 QVDYLRNFTQGLVEDA---PDGSDASQLLHQAEVAQQEFLEVKQRVNSGCVMMENKLEG- 3058

Query: 2035 AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER 2094
             + Q    +++   Q   + D+L G     R             + ++ QS  Q+E+   
Sbjct: 3059 -IGQFHCRVREMFSQLADLDDELDGMGAIGR-------------DTDSLQS--QIEDVRL 3102

Query: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEK-HKKFAE 2153
                                KL  EA +   R    E+  L        E+E  +K+  +
Sbjct: 3103 FLNKIH------------VLKLDIEASEAECRHMLEEEGTL-DLLGLKRELEALNKQCGK 3149

Query: 2154 QTLRQKAQVEQ-ELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVR 2212
             T R KA+ EQ ELT  R++    D  + L         AE  EA +     E E+ + +
Sbjct: 3150 LTERGKARQEQLELTLGRVE----DFYRKLKGLNDATTAAEEAEALQWVVGTEVEIINQQ 3205

Query: 2213 V------QMEELSKLKARIEAEN---RALILR-DKDNTQRFLQEEAEKM--------KQV 2254
            +      Q E++  L+ +++  N   + LI    KD   + L+ + E++        K+V
Sbjct: 3206 LADFKMFQKEQVDPLQMKLQQVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKV 3265

Query: 2255 AEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2314
            A+  A+L  A     + +  A E L    A  E+++  +     E   +KA+   +Q+QK
Sbjct: 3266 AQRIAQLQEALLHCGKFQD-ALEPLLSWLADTEELIANQKPPSAEYKVVKAQ---IQEQK 3321

Query: 2315 ELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-SRA 2373
             L     +RL +D++     L  + +G +    AE   + +++ + E L+ R  E+ S+A
Sbjct: 3322 LL-----QRLLDDRKATVDML--QAEGGRIAQSAELADREKITGQLESLESRWTELLSKA 3374

Query: 2374 QARAE--ED----AQRFRKQAEEIGEKLHRTE--LATQEKVTLVQTLEIQRQQSDHDAER 2425
             AR +  ED    A++F + AE I + L  TE  LA  E V   QT +IQ+Q   H A  
Sbjct: 3375 AARQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKA-- 3431

Query: 2426 LREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEK-DSLLQRE 2484
            L E   ++E     + Q  K+ Q             L   T   +Q  LSEK DSL  R 
Sbjct: 3432 LEE---DIENHATDVHQAVKIGQ------------SLSSLTSPAEQGVLSEKIDSLQARY 3476

Query: 2485 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
              I+    +   L    ++ A+   E++                                
Sbjct: 3477 SEIQDRCCRKAALLDQALSNARLFGEDEV------------------------------- 3505

Query: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2604
                E L  L +   +   +  ++ ++      +L  QH   LA +EE+   +    + +
Sbjct: 3506 ----EVLNWLAEVEDKLSSVFVKDFKQ-----DVLHRQHADHLALNEEIVNRKKNVDQAI 3556

Query: 2605 PNGRDALDGPAAEAE--PEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652
             NG+  L     E     +   DG++      R  +  + S++ L+ L Q
Sbjct: 3557 KNGQALLKQTTGEEVLLIQEKLDGIK-----TRYADITVTSSKALRTLEQ 3601



 Score =  100 bits (249), Expect = 3e-20
 Identities = 316/1613 (19%), Positives = 616/1613 (38%), Gaps = 239/1613 (14%)

Query: 1004 QQKAQAEVEGLGKGVARLSAEAEKVLALP----EPSPAAPTLRSELELTLGKLEQVRSLS 1059
            Q K Q +V GLG+G+ + + +   V  L     E +    TL  ++   + +L++     
Sbjct: 3221 QMKLQ-QVNGLGQGLIQSAGKDCDVQGLEHDMEEINARWNTLNKKVAQRIAQLQEALLHC 3279

Query: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119
              + + L+ +   +  T   EE++   +    E + V A + E        K L+   + 
Sbjct: 3280 GKFQDALEPLLSWLADT---EELIANQKPPSAEYKVVKAQIQEQ-------KLLQRLLDD 3329

Query: 1120 QQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLE----RWQAVLAQTDV 1175
            ++ T D L+ E       G R+ Q     D      RE++   LE    RW  +L++   
Sbjct: 3330 RKATVDMLQAE-------GGRIAQSAELAD------REKITGQLESLESRWTELLSKAAA 3376

Query: 1176 RQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEE 1235
            RQ++LE +    + + E+A+P+  +L    ++    + +    +  +++Q+ + +AL E+
Sbjct: 3377 RQKQLEDILVLAKQFHETAEPISDFLSVTEKKLANSEPVG-TQTAKIQQQIIRHKALEED 3435

Query: 1236 IERHGEKVEECQRF----------AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS 1285
            IE H   V +  +           A+Q + + K   LQ    + Q       A   +  S
Sbjct: 3436 IENHATDVHQAVKIGQSLSSLTSPAEQGVLSEKIDSLQARYSEIQDRCCRKAALLDQALS 3495

Query: 1286 GSESVIQEYVDLRTHYSEL-TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
             +    ++ V++    +E+   L+S ++K   + +   +  + LA  +    R++  + +
Sbjct: 3496 NARLFGEDEVEVLNWLAEVEDKLSSVFVKDFKQDVLHRQHADHLALNEEIVNRKKNVD-Q 3554

Query: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQK------RSIQE 1398
            A    Q  L +   +     + +   ++ R  +  V   +A    +Q +      +S  E
Sbjct: 3555 AIKNGQALLKQTTGEEVLLIQEKLDGIKTRYADITVTSSKALRTLEQARQLATKFQSTYE 3614

Query: 1399 ELQQLRQSSEAEIQAKARQAEAAE------RSRLRIEEEIRVVRLQLEATERQRGGAEGE 1452
            EL    +  E E+     Q+   E      + +  +++E+   RL L+ T  +   A  E
Sbjct: 3615 ELTGWLREVEEELATSGGQSPTGEQIPQFQQRQKELKKEVMEHRLVLD-TVNEVSRALLE 3673

Query: 1453 LQALRAR------AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
            L   RAR        +A  Q +   +   +   ++    QR +Q E        AE    
Sbjct: 3674 LVPWRAREGLDKLVSDANEQYKLVSDTIGQRVDEIDAAIQRSQQYE----QAADAELAWV 3729

Query: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASF--- 1563
             E +R L AL  +RL   E ++   Q +V++A  + +      + +  EL S R+     
Sbjct: 3730 AETKRKLMALGPIRL---EQDQTTAQLQVQKAFSIDI---IRHKDSMDELFSHRSEIFGT 3783

Query: 1564 ---AEKTAQLER--SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANE 1618
                +KT   E+  SL +++ A++ L  E   R ++         E   EL  W ++   
Sbjct: 3784 CGEEQKTVLQEKTESLIQQYEAISLLNSERYARLERAQVLVNQFWETYEELSPW-IEETR 3842

Query: 1619 ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR--------GKAEEQAVRQRELAEQ 1670
            AL  +L +  +  ++   Q E  +Q  E+  E +           + +E    + E+ E+
Sbjct: 3843 ALIAQLPSPAIDHEQLRQQQEEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEE 3902

Query: 1671 ELEKQR----QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE--EELA---RLQREA 1721
            + +K      Q+ E   Q+ LA ++ + +    TE  ++   +LE  E L+   R+    
Sbjct: 3903 KYQKAENMYAQIKEEVRQRALALDEAVSQSTQITEFHDKIEPMLETLENLSSRLRMPPLI 3962

Query: 1722 AAATQKRQELEAELAKVRAEMEVLLAS----KARAEE-ESRSTSEKSKQRLEAEAGRFRE 1776
             A   K +E  ++      E+E L  S    K R EE   RS         +    +  +
Sbjct: 3963 PAEVDKIRECISDNKSATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQ 4022

Query: 1777 LAEEAARLRALAEEAKRQ----RQLAEE-----DAARQRAEAERVLAEKLAAIG-EATRL 1826
            +      ++A AEE + +     +LAE+      A     +  + +   L + G + + +
Sbjct: 4023 MVFFWEDIKARAEEREIKFLDVLELAEKFWYDMAALLTTIKDTQDIVHDLESPGIDPSII 4082

Query: 1827 KTEAEIALKEKE------AENERLRRLAEDEAFQRRRLEEQAAQHKAD-IEERLAQLRKA 1879
            K + E A   KE       E E +R L  D  F     E+   +   D +      L K 
Sbjct: 4083 KQQVEAAETIKEETDGLHEELEFIRILGADLIFACGETEKPEVRKSIDEMNNAWENLNKT 4142

Query: 1880 SDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRS 1939
                LE+    +ED ++   Q ++ + A+    +        +   +G   +  +D L  
Sbjct: 4143 WKERLEK----LEDAMQAAVQYQDTLQAMFDWLDNTVIKLCTMP-PVGTDLNTVKDQLNE 4197

Query: 1940 KEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEA 1999
             ++ ++E  +Q+    E E+   + E  ++K  A +E      +  L E++ L   + E 
Sbjct: 4198 MKEFKVEVYQQQ---IEMEKLNHQGELMLKK--ATDETDRDIIREPLTELKHLWENLGE- 4251

Query: 2000 RRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRG 2059
             ++  R  +     L L Q                  Q   +EL   L   + +LD  R 
Sbjct: 4252 -KIAHRQHKLEGALLALGQ-----------------FQHALEELMSWLTHTEELLDAQRP 4293

Query: 2060 --------EAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
                    E E A+    + +    QA  E           E L+ SA + A +      
Sbjct: 4294 ISGDPKVIEVELAKHHVLKNDVLAHQATVETVNKAGN----ELLESSAGDDASSLRSRLE 4349

Query: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRL 2171
            A  +  +   Q+   R Q  Q+ L+Q Q   +E+E                  ELT +  
Sbjct: 4350 AMNQCWESVLQKTEEREQQLQSTLQQAQGFHSEIE--------------DFLLELTRMES 4395

Query: 2172 QLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRA 2231
            QL  +     L             E AR++     EL+         S+LKA+ E  N+ 
Sbjct: 4396 QLSASKPTGGL------------PETAREQLDTHMELY---------SQLKAKEETYNQL 4434

Query: 2232 LILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2291
            L   DK       ++++    +  +  A L       +   +  +  L +   LA +   
Sbjct: 4435 L---DKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEALNLATEFQN 4491

Query: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
               + +   T       L +Q   +A   +  L     Q+     EE + F   + A R 
Sbjct: 4492 SLQEFINWLT-------LAEQSLNIASPPSLILNTVLSQI-----EEHKVFANEVNAHRD 4539

Query: 2352 RQLEMSAEAERLKLRVAE---------MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402
            + +E+     +LK    +         +   Q+R E+  QR  ++   + +   R +   
Sbjct: 4540 QIIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSIERGRSLDDARKRAKQFH 4599

Query: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2462
            +    L+  LE        DAE   ++  E+  + +K++ +   L    E  +T+  +Q 
Sbjct: 4600 EAWKKLIDWLE--------DAESHLDSELEISNDPDKIKLQ---LSKHKEFQKTLGGKQP 4648

Query: 2463 LQET-----QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
            + +T     +AL++  L  +DS  + + F+ + + K + +    V +  +L E
Sbjct: 4649 VYDTTIRTGRALKEKTLLPEDS-QKLDNFLGEVRDKWDTVCGKSVERQHKLEE 4700



 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 235/1255 (18%), Positives = 480/1255 (38%), Gaps = 105/1255 (8%)

Query: 898  EEQRQALHSL---ELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGA 954
            EE RQ   S+   + H    L+         PE+  M E +Y    + Y Q+ + + Q A
Sbjct: 3863 EEMRQLRESIAEHKPHIDKLLKIGPQLKELNPEEGEMVEEKYQKAENMYAQIKEEVRQRA 3922

Query: 955  ---QEESRCQRCISELKD-IRLQLEACETRTVHRLR----LPLDKEPARECAQRIAEQQK 1006
                E       I+E  D I   LE  E  +  RLR    +P + +  REC   I++ + 
Sbjct: 3923 LALDEAVSQSTQITEFHDKIEPMLETLENLS-SRLRMPPLIPAEVDKIREC---ISDNKS 3978

Query: 1007 AQAEVEGLGKGVARLSAEAEKVLALPEPSP---AAPTLRSELELTLGKLEQVRS-LSAIY 1062
            A  E+E L      L    E+++   + +    AA  ++ +L+  +   E +++      
Sbjct: 3979 ATVELEKLQPSFEALKRRGEELIGRSQGADKDLAAKEIQDKLDQMVFFWEDIKARAEERE 4038

Query: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1122
            ++ L  + L  +       +L      +K+ Q +   L       + +K+    AE  + 
Sbjct: 4039 IKFLDVLELAEKFWYDMAALLTT----IKDTQDIVHDLESPGIDPSIIKQQVEAAETIKE 4094

Query: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
              D L +EL   + +G  L    GE   E    R+ + ++   W+ +      R  +LE 
Sbjct: 4095 ETDGLHEELEFIRILGADLIFACGE--TEKPEVRKSIDEMNNAWENLNKTWKERLEKLED 4152

Query: 1183 LGRQLRYYRESADPLGAWLQDARRRQEQIQAMPL--ADSQAVREQLRQEQALLEEIERHG 1240
              +    Y+++   +  WL +      ++  MP    D   V++QL + +    E+ +  
Sbjct: 4153 AMQAAVQYQDTLQAMFDWLDNT---VIKLCTMPPVGTDLNTVKDQLNEMKEFKVEVYQ-- 4207

Query: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
                  Q+   + +N   +  L+  T +   + +  P  + K    +   + E +  R H
Sbjct: 4208 ------QQIEMEKLNHQGELMLKKATDETDRDIIREPLTELKHLWEN---LGEKIAHRQH 4258

Query: 1301 YSELTTLT-SQYIKFISETLRRMEEEERLAEQQRAEERE-RLAEVEAALEKQRQLAEAHA 1358
              E   L   Q+   + E +  +   E L + QR    + ++ EVE        LA+ H 
Sbjct: 4259 KLEGALLALGQFQHALEELMSWLTHTEELLDAQRPISGDPKVIEVE--------LAKHHV 4310

Query: 1359 -QAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1417
             +    A +   E   +   E++  E +A D     RS  E + Q  +S   + + + +Q
Sbjct: 4311 LKNDVLAHQATVETVNKAGNELL--ESSAGDDASSLRSRLEAMNQCWESVLQKTEEREQQ 4368

Query: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477
             ++  +       EI    L+L   E Q   +    +      E A  Q     E   +L
Sbjct: 4369 LQSTLQQAQGFHSEIEDFLLELTRMESQLSAS----KPTGGLPETAREQLDTHMELYSQL 4424

Query: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEV 1535
            + + +  +Q   +  + L SR  + + +  E+  AL  Q    +  + EE + +L +A +
Sbjct: 4425 KAKEETYNQLLDKGRLMLLSRDDSGSGSKTEQSVALLEQKWHVVSSKMEERKSKLEEA-L 4483

Query: 1536 ERARQVQVAL-ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
              A + Q +L E       AE     AS          S  EEH   A    E      Q
Sbjct: 4484 NLATEFQNSLQEFINWLTLAEQSLNIASPPSLILNTVLSQIEEHKVFA---NEVNAHRDQ 4540

Query: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQKSLAQAEAEKQKEEAEREARR 1653
              E ++   + +   ++  +   + L + +Q+  E   Q+S+   E  +  ++A + A++
Sbjct: 4541 IIELDQTGNQLKFLSQKQDVVLIKNLLVSVQSRWEKVVQRSI---ERGRSLDDARKRAKQ 4597

Query: 1654 RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEE 1713
              +A ++ +   E AE  L+ + +++    + +L   +   +   +T  G+Q        
Sbjct: 4598 FHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSKH--KEFQKTLGGKQPVYDTTIR 4655

Query: 1714 LARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE---EESRSTSEKSKQRLEAE 1770
              R  +E     +  Q+L+  L +VR + + +       +   EE+   S +    L+A 
Sbjct: 4656 TGRALKEKTLLPEDSQKLDNFLGEVRDKWDTVCGKSVERQHKLEEALLFSGQFMDALQAL 4715

Query: 1771 AGRFRELAEEAAR-----------LRALAEEAKRQRQLAEEDAARQ------RAEAERVL 1813
                 ++  + A            +  +      Q++L +     Q      R   E   
Sbjct: 4716 VDWLYKVEPQLAEDQPVHGDLDLVMNLMDAHKVFQKELGKRTGTVQVLKRSGRELIENSR 4775

Query: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1872
             +     G+   L T  +   K   ++  RL + L + E F  R       +  ++ E+ 
Sbjct: 4776 DDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALKQAEVF--RDTVHMLLEWLSEAEQT 4833

Query: 1873 LAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
            L + R A   + E  + L++      ++VEE+ + + ++        A    +      +
Sbjct: 4834 L-RFRGALPDDTEALQSLIDTHKEFMKKVEEKRVDVNSAVAMGEVILAVCHPDCITTIKH 4892

Query: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA------RQRKAAL 1986
                +R++ +  L  A+Q Q   E       A   + + L A  + A      R ++   
Sbjct: 4893 WITIIRARFEEVLTWAKQHQQRLETALSELVANAELLEELLAWIQWAETTLIQRDQEPIP 4952

Query: 1987 EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQT 2046
            + ++R+KA + E +   E   ++     ++ +   +K +   E  HA  +++     +++
Sbjct: 4953 QNIDRVKALIAEHQTFMEEMTRKQPDVDRVTKTYKRKNI---EPTHAPFIEKSRSGGRKS 5009

Query: 2047 LQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEA-ERLKQSAE 2100
            L Q       +  ++EA      +      Q    A + +R++ +A +RL++  E
Sbjct: 5010 LSQPTPPPMPILSQSEAKNPRINQLSARWQQVWLLALERQRKLNDALDRLEELKE 5064



 Score = 39.7 bits (91), Expect = 0.069
 Identities = 26/54 (48%), Positives = 27/54 (50%), Gaps = 2/54 (3%)

Query: 4457 SVSGSGSTAGSRTGSRTGSRAGSRRGSFD--ATGSGFSMTFSSSSYSSSGYGRR 4508
            S S  GS AGSR GSR  SR GS    FD   T S  S T  SS+    G  RR
Sbjct: 5350 SASRPGSRAGSRAGSRASSRRGSDASDFDLLETQSACSDTSESSAAGGQGNSRR 5403



 Score = 34.3 bits (77), Expect = 2.9
 Identities = 49/247 (19%), Positives = 98/247 (39%), Gaps = 25/247 (10%)

Query: 483  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 535
            +V  +S++R   L+D+  R  Q       L+ W+E+ +  +D   E   D   ++ QL  
Sbjct: 4576 KVVQRSIERGRSLDDARKRAKQFHEAWKKLIDWLEDAESHLDSELEISNDPDKIKLQLSK 4635

Query: 536  HR------GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKAR 589
            H+      G  Q + +   +  RA  ++  L P       + LG +  ++  +   S  R
Sbjct: 4636 HKEFQKTLGGKQPVYDTTIRTGRALKEK-TLLPEDSQKLDNFLGEVRDKWDTVCGKSVER 4694

Query: 590  LRSLESL----HSFVAAATKELMWLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMR 641
               LE        F+ A    + WL + E    E++      D   N+    +++    +
Sbjct: 4695 QHKLEEALLFSGQFMDALQALVDWLYKVEPQLAEDQPVHGDLDLVMNLM---DAHKVFQK 4751

Query: 642  ELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAA 701
            EL  +   ++ L+ +G  L+         V+     L T+W  + +L    ++ L++   
Sbjct: 4752 ELGKRTGTVQVLKRSGRELIENSRDDTTWVKGQLQELSTRWDTVCKLSVSKQSRLEQALK 4811

Query: 702  YFQFFSD 708
              + F D
Sbjct: 4812 QAEVFRD 4818


>gi|207452735 epiplakin 1 [Homo sapiens]
          Length = 5090

 Score = 1268 bits (3280), Expect = 0.0
 Identities = 798/1967 (40%), Positives = 1134/1967 (57%), Gaps = 218/1967 (11%)

Query: 2615 AAEAEP-EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2673
            AAE +P + +F GLR++VSA+ L  A ++S + L  L+QG TTV E+A  + V+  L+G 
Sbjct: 1511 AAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGG 1570

Query: 2674 SSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVK 2733
            + IAG+L++ T E++S+  AL+R +L PGTAL+LLEAQAA+GF++DP  NR+LTV EA K
Sbjct: 1571 NFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFK 1630

Query: 2734 EGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGV 2793
             G+ G E + KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGG+
Sbjct: 1631 AGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGI 1690

Query: 2794 IDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDP 2853
            IDPVHSHRVPVDVAYR GYFDEEMNR+LADPSDDTKGFFDPNTHENLTYLQLLERCVEDP
Sbjct: 1691 IDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDP 1750

Query: 2854 ETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTA 2913
            ETGL LL +     KG   VY +   R V +  T     G+F  + V+ W++++S YFT 
Sbjct: 1751 ETGLYLLQI---IKKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTE 1807

Query: 2914 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQE-QKGRLCFEGLRSLVPAAELLESRVIDR 2972
            +++R+L++++      +EK+++II T +EE E Q   +    +R  V AA+L  SRVID+
Sbjct: 1808 DRKRELIQEYGAQSGGLEKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQ 1867

Query: 2973 ELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMA 3032
            +    L+ G    + ++ ++ V+  L G++ IAGV +    + +S++ A +K+L+P+  A
Sbjct: 1868 KTLHTLRVGRTGGQALSTLECVKPYLEGSDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927

Query: 3033 VALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSV 3092
              LLEAQA TG ++DP T  +L+VDEAV  GLV  E  E+LL AE+A TGYRDP TG ++
Sbjct: 1928 TWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDPATGDTI 1987

Query: 3093 SLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAP 3152
             LFQA++K LI + + LRLL+ Q++TGG++DP   HR+PL+ A  RGCL ++    +S  
Sbjct: 1988 PLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQ 2047

Query: 3153 RADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETF 3212
            +   K + DP+T E  +Y ELQ+RCRP + TG  L P++ KAAR   +  + + + R   
Sbjct: 2048 KHMRKRFVDPNTQEKVSYRELQERCRPQEDTGWVLFPVN-KAAR---DSEHIDDETRRAL 2103

Query: 3213 EKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRT-GKVTVEKVIKILITIVE 3271
            E   VE+ VG F+G+  T+W L++SEY T E++ +L+R +RT  +  ++ V ++++ ++E
Sbjct: 2104 EAEQVEITVGRFRGQKPTLWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILELIE 2163

Query: 3272 EVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQG 3331
            + ET   + L F G+R  + ASELL+S +++    + L+ G++T ++L E   V+  L+G
Sbjct: 2164 KQET-SNKHLWFQGIRRQITASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEG 2222

Query: 3332 SGCLAGIYL-----EDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLY 3386
            + C+AG+ +        +EK+SIY+AM +G+LR  TA +LLEAQAATGF++DPVRN RL 
Sbjct: 2223 TSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLS 2282

Query: 3387 VHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQ 3446
            V E V AGVVG E+ E+LLSAE+AVTGY DPY+G  ISLFQAMQK L++R+HGIRLLEAQ
Sbjct: 2283 VEEPVPAGVVGSEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQ 2342

Query: 3447 IATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLE 3506
            IATGG+IDPVHSHRVPVDVAY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL 
Sbjct: 2343 IATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLR 2402

Query: 3507 RCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLW 3566
            RCV DP+TGL +L L G   A           EE R A  + ++  PG G+  G ++S+W
Sbjct: 2403 RCVPDPDTGLYMLQLAGRGSA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVW 2455

Query: 3567 EVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLT 3626
            E++    + E++R  L++ ++AG +T E +   +  ++ + +             + R  
Sbjct: 2456 ELLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQ------------AQARAE 2503

Query: 3627 AEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQ 3686
            A    EA     +    LR  T  ++               G + G  +P       ++ 
Sbjct: 2504 A----EAGSPRPDPREALRAATMEVK--------------VGRLRGRAVP-------VWD 2538

Query: 3687 ALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER 3744
             L  G +S   AR  L A+  +G L  P    RLT  ++EA       P+L D       
Sbjct: 2539 VLASGYVS-RAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDARRGPRE 2597

Query: 3745 ---AVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV 3800
               A  G  D    Q     +   +E      A R  +  L    +   R  F   P+ V
Sbjct: 2598 PGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSV 2657

Query: 3801 --AYQRGYLNKDTHDQ-----------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDG 3847
                   YL++   D+           L +   V + V   T+ERLS             
Sbjct: 2658 WDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLS------------- 2704

Query: 3848 TGQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQK 3905
                        K++FRGLR+Q++  EL  S ++   T   L +G  +++EVT+  ++++
Sbjct: 2705 ------------KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKR 2752

Query: 3906 FLEGTSCIAGVFVDA-----TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKG 3960
            +LEGTSCIAGV V A      +E++S+YQAM KG++RPGTA  LLEAQAATG+VIDP++ 
Sbjct: 2753 YLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRN 2812

Query: 3961 LKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRL 4020
            L+L+VEEAV  G+VG E ++KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRL
Sbjct: 2813 LRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRL 2872

Query: 4021 LEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYL 4080
            LEAQIATGG+IDP  SHR+PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTY+
Sbjct: 2873 LEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYV 2932

Query: 4081 QLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPET----GKEMSVYE-- 4134
            QL+ RC+ DP TGL +L L  +       S+      R   V P +    G+ +SV+E  
Sbjct: 2933 QLLRRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELL 2992

Query: 4135 ---------------AYRKGLIDHQ------TYLELSEQECEWEEITISSS--------D 4165
                            YR G +  +      T L    Q     E    S          
Sbjct: 2993 FYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALR 3052

Query: 4166 GVVKSMIIDRRSGRQYDIDDAIAKNLIDRSA----LDQYRAGTLSITEFADMLS------ 4215
                 + + R  GR   + D +A   +  +A    L ++ +GTL +      L+      
Sbjct: 3053 AATMEVKVGRLRGRAVPVWDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAIIEEA 3112

Query: 4216 ---------------------------GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASW 4248
                                       G++G  +      G +     + A +R Q  + 
Sbjct: 3113 EEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQEQTL 3172

Query: 4249 SDPTEET--GPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGI------- 4299
             D T E   G   G         VS+ + +  + +       LL AQ   G +       
Sbjct: 3173 RDATMEVQRGQFQG-------RPVSVWDVLFSSYLSEARRDELL-AQHAAGALGLPDLVA 3224

Query: 4300 ----IDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKG 4355
                +   T ER  ++    +GL  ++    ++ +     G   P T   ++      + 
Sbjct: 3225 VLTRVIEETEER--LSKVSFRGLRRQVSASELHTS-----GILGPETLRDLAQGTKTLQE 3277

Query: 4356 WLYYEAGQRFLEVQYLTGGLIEP--DTPGR---VPLDEALQRGTVDARTAQKLRDVGAYS 4410
                ++ +R+LE      G++ P  D PGR   + + +A+ +G +   TA  L +  A +
Sbjct: 3278 VTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAAT 3337

Query: 4411 KYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYS 4457
             ++  P   L++S ++A+   +V      +LL +A ++  GY  PY+
Sbjct: 3338 GFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL-SAERAVTGYTDPYT 3383



 Score = 1179 bits (3049), Expect = 0.0
 Identities = 740/1890 (39%), Positives = 1067/1890 (56%), Gaps = 172/1890 (9%)

Query: 2623 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2682
            +F  +   VSA  L E GIL  + +Q L +G     +++ R +VR YL+G  S+AG++L 
Sbjct: 234  TFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLL 293

Query: 2683 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2742
                K S + A    LL  GTAL LLEAQAA+  L+DP+  +RL V+EAV+ G+V PELH
Sbjct: 294  PEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLVDPITGQRLWVDEAVRAGLVSPELH 353

Query: 2743 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2802
             +LL AE+AVTG+ DP++G QI LFQAM+KGL+ R   +RLL+AQ+ATGG++ P    R+
Sbjct: 354  EQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRPLALRLLDAQLATGGLVCPARRLRL 413

Query: 2803 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2862
            P++ A R G  DE+  R L+       G F   TH  L Y QLL  CV DPETGL  LPL
Sbjct: 414  PLEAALRCGCLDEDTQRQLSQA-----GSFSDGTHGGLRYEQLLALCVTDPETGLAFLPL 468

Query: 2863 TDKAAKGGELV---YTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDL 2919
            +    +GGE     +     R     AT +   GKF+G+ V++WE++ SE  ++EQR  L
Sbjct: 469  SG-GPRGGEPQGPPFIKYSTRQALSTATATVSVGKFRGRPVSLWELLFSEAISSEQRAML 527

Query: 2920 LRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQ 2979
             +Q++ G ++VEK+   +   +E+     R+ F GLR  V   ELL++ +ID++LY++L+
Sbjct: 528  AQQYQEGTLSVEKLAAELSATLEQAAATARVTFSGLRDTVTPGELLKAEIIDQDLYERLE 587

Query: 2980 RGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQ 3039
             G+ + +DV  + + +R L+G   IAG+ L  + ++LSIY A  K LL    A+ LLEAQ
Sbjct: 588  HGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQ 647

Query: 3040 AGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3099
            A TG IIDP  +   +V+EA+RA ++GP+   KLLSAE+AVTGY DPYTGQ +SLFQA++
Sbjct: 648  AATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQ 707

Query: 3100 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3159
            KGLI RE G+RLL+AQ++TGG++DP  SHRVP+DVA  RG  D+  +  L  P  D K +
Sbjct: 708  KGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGF 767

Query: 3160 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3219
             DP+T E  TY +L +RC  D  TGL LLPLS     + Q  L  +   ++ F+   + V
Sbjct: 768  FDPNTHENLTYLQLLERCVRDPETGLYLLPLS-----STQSPLV-DSATQQAFQNLLLSV 821

Query: 3220 PVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQE 3279
              G F+G+ V+ WELI+SEYF+  +R++LLR++R  +VT+ +V K+L     E ET RQ 
Sbjct: 822  KYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREVTLGQVAKLL-----EAETQRQA 876

Query: 3280 RLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIY 3339
             +    LR+ V   +LL +G++ +   +Q+  G  + + L  +  VR  L G G + G+ 
Sbjct: 877  DIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDGVRRYLCGLGAVGGVR 936

Query: 3340 LEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPE 3399
            L  + +++S+Y+AMR+ LL    A  LLEAQAATG ++DP   + L V EAV+ GVVGPE
Sbjct: 937  LLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPESLSVDEAVRRGVVGPE 996

Query: 3400 LHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSH 3459
            L+ +L  AE A+ G+RDP+SG  +S+FQAM+KGL+  +   RLLEAQ+ATGGIIDP   H
Sbjct: 997  LYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLEAQVATGGIIDPTSHH 1056

Query: 3460 RVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3519
             +P+ VA QRGY  +EM   L+  S+    F  P+     +Y QLLE C  D  +GL LL
Sbjct: 1057 HLPMPVAIQRGYVDQEMETALSSSSET---FPTPDGQGRTSYAQLLEECPRDETSGLHLL 1113

Query: 3520 PLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQR 3579
            PL  +  A       + TEE+ +R+ +     +PG         SLW+++ S    EEQR
Sbjct: 1114 PLPESAPA-------LPTEEQVQRSLQA----VPG----AKDGTSLWDLLSSCHFTEEQR 1158

Query: 3580 AQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLE 3639
              L+ D Q GR T  +++  +   +++T+++  Q        R  + A  L +A II+ E
Sbjct: 1159 RGLLEDVQEGRTTVPQLLASVQRWVQETKLL-AQARVMVPGPRGEVPAVWLLDAGIITQE 1217

Query: 3640 TYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVAR 3699
            T   L +GT+S  +  E  +    L+GTG VAGV L  S    SI QA++ GLL   + +
Sbjct: 1218 TLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQ 1277

Query: 3700 LLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTIS 3759
             LLEAQ A+GFL+DP+  +RL+V++AV+ GLVG EL ++L  AERA  GY DPY+  ++S
Sbjct: 1278 RLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAAGYPDPYSRASLS 1337

Query: 3760 LFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSE-P 3818
            L+QAM+K L+P  E L LL  QLATGG+VDP  G HLP   A + G L+  T   L+   
Sbjct: 1338 LWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLLDTQTSQVLTAVD 1397

Query: 3819 SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--------SDARKLTFRGLRKQI 3870
             + + + DPS  ++++Y QL  RC  D  TG LLLPL         D   +  R ++  +
Sbjct: 1398 KDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDHTAVALRAMKVPV 1457

Query: 3871 T---------------MEELVRSQVMDEATAL----------QLREGLTSIEEVT----- 3900
            +               + E V +    E  AL          Q+   +T++ E       
Sbjct: 1458 STGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQVVSAVTALVEAAERQPL 1517

Query: 3901 ------------------------KNLQKFLEGTSCIAGVF-VDATKERL---------- 3925
                                    K L +  +GT+ +  V  +D+ K  L          
Sbjct: 1518 QATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEMDSVKRSLEGGNFIAGVL 1577

Query: 3926 --------SVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPE 3977
                    S+ +A+++ I+RPGTA  LLEAQAATG++IDP +  KLTVEEA + G+ G E
Sbjct: 1578 IQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKE 1637

Query: 3978 FKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESH 4037
               KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIATGGIIDP  SH
Sbjct: 1638 TYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSH 1697

Query: 4038 RLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLL 4097
            R+PV+VAY+ G FDEEMN IL DPSDDTKGFFDPNT ENLTYLQL+ERC+ DP+TGL LL
Sbjct: 1698 RVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLL 1757

Query: 4098 PLKEK-------KRERKTSSKSSVRKRRV-----------------VIVDPETGKEMSVY 4133
             + +K           +   +S   K RV                    +    + +  Y
Sbjct: 1758 QIIKKGENYVYINEATRHVLQSRTAKMRVGRFADQVVSFWDLLSSPYFTEDRKRELIQEY 1817

Query: 4134 EAYRKGLIDHQTYLE-----LSEQECEWEEITISSSDGVV------KSMIIDRRSGRQYD 4182
             A   GL   +  LE     + E E + + I +++  G V       S +ID+++     
Sbjct: 1818 GAQSGGL---EKLLEIITTTIEETETQNQGIKVAAIRGEVTAADLFNSRVIDQKTLHTLR 1874

Query: 4183 IDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSR 4242
            +     + L     +  Y  G       +D ++G          S+  +S   + PA   
Sbjct: 1875 VGRTGGQALSTLECVKPYLEG-------SDCIAGVTVPSTREVMSLHEASRKELIPAAFA 1927

Query: 4243 TQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDP 4302
            T L       E       +LD  T +K+S+ EA+   LV+    +RLL+A+    G  DP
Sbjct: 1928 TWL------LEAQAATGFLLDPCTRQKLSVDEAVDVGLVNEELRERLLKAERAATGYRDP 1981

Query: 4303 STGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAG 4362
            +TG+  P+  A+ K L++K    R+   Q A  G  DP+   ++    A ++G L+ +  
Sbjct: 1982 ATGDTIPLFQAMQKQLIEKAEALRLLEVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIY 2041

Query: 4363 QRFLEVQYLTGGLIEPDTPGRVPLDEALQR 4392
                + +++    ++P+T  +V   E  +R
Sbjct: 2042 ALISDQKHMRKRFVDPNTQEKVSYRELQER 2071



 Score = 1138 bits (2943), Expect = 0.0
 Identities = 742/1981 (37%), Positives = 1094/1981 (55%), Gaps = 185/1981 (9%)

Query: 2574 EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA 2633
            EQ  +L +Q++      E++ A++++AT         L+  AA A    +F GLR  V+ 
Sbjct: 522  EQRAMLAQQYQEGTLSVEKL-AAELSAT---------LEQAAATARV--TFSGLRDTVTP 569

Query: 2634 QRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAA 2693
              L +A I+  +  +RL  G  T  ++      + YLQG   IAGLLL  + E+LS+Y A
Sbjct: 570  GELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQERLSIYEA 629

Query: 2694 LQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVT 2753
              + LL PGTALILLEAQAA+GF++DP  N+  +V EA++  V+GP++  KLLSAERAVT
Sbjct: 630  RCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLLSAERAVT 689

Query: 2754 GYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 2813
            GY DPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF
Sbjct: 690  GYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYF 749

Query: 2814 DEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELV 2873
            D+ +N +L DPSDDTKGFFDPNTHENLTYLQLLERCV DPETGL LLPL+   +      
Sbjct: 750  DQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLSSTQSP----- 804

Query: 2874 YTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKI 2933
              DS  +  F+   +S  +G+FQG+ V+ WE+INSEYF+  +RR LLR++R   +T+ ++
Sbjct: 805  LVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQLLRRYRQREVTLGQV 864

Query: 2934 IKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDT 2993
             K++     E +++  +    LRS V   +LLE+ +ID++L  Q+  G  S   +  +D 
Sbjct: 865  AKLLEA---ETQRQADIMLPALRSRVTVHQLLEAGIIDQQLLDQVLAGTISPEALLLMDG 921

Query: 2994 VRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSAR 3053
            VRR L G   + GV L  +GQ+LS+Y A+++ LL   +A+ALLEAQA TG I+DP +   
Sbjct: 922  VRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQAATGTIMDPHSPES 981

Query: 3054 LTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLD 3113
            L+VDEAVR G+VGPE + +L  AE A+ G+RDP++G+ VS+FQA+KKGLIP EQ  RLL+
Sbjct: 982  LSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMKKGLIPWEQAARLLE 1041

Query: 3114 AQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGEL 3173
            AQ++TGGI+DP+  H +P+ VA  RG +D+E   ALS+    ++ +  P      +Y +L
Sbjct: 1042 AQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSS---SSETFPTPDGQGRTSYAQL 1098

Query: 3174 QQRCRPDQLTGLSLLPLSEKA-ARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVW 3232
             + C  D+ +GL LLPL E A A   +E++   LQA            V G K  T ++W
Sbjct: 1099 LEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQA------------VPGAKDGT-SLW 1145

Query: 3233 ELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPA 3292
            +L+SS +FT EQR+ LL   + G+ TV +++  +   V+E + L Q R+   G R  VPA
Sbjct: 1146 DLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGEVPA 1205

Query: 3293 SELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEA 3352
              LL +G++++   E L  G  +   ++E  +V+  L G+GC+AG+ L+ +  K SI +A
Sbjct: 1206 VWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQA 1265

Query: 3353 MRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVT 3412
            +R GLL       LLEAQ A+GFLVDP+ NQRL V +AVK G+VG EL EQL  AE+A  
Sbjct: 1266 VRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAA 1325

Query: 3413 GYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYF 3472
            GY DPYS +++SL+QAM+KGLV +  G+ LL+ Q+ATGG++DPVH   +P   A + G  
Sbjct: 1326 GYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLL 1385

Query: 3473 SEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVET 3532
              + ++VL     D K FFDP+  + +TY+QL ERCV D ETGL LLPL      EV + 
Sbjct: 1386 DTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDH 1445

Query: 3533 TQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVT 3592
            T V        A    ++ +   G   G ++SLW+++ S+ +  ++R +L+A  ++GR  
Sbjct: 1446 TAV--------ALRAMKVPV-STGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAA 1496

Query: 3593 KERMII-IIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSL 3651
              R ++  +  ++E  E  RQ   A++  +R++++A DLF A++IS +T + L +GT ++
Sbjct: 1497 ALRQVVSAVTALVEAAE--RQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTV 1554

Query: 3652 REALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFL 3711
            +E  E +S    L G   +AGV + G+++ +SI +AL++ +L    A +LLEAQAATGF+
Sbjct: 1555 KEVAEMDSVKRSLEGGNFIAGVLIQGTQERMSIPEALRRHILRPGTALVLLEAQAATGFI 1614

Query: 3712 LDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPT 3771
            +DP +  +LTV+EA + G+ G E + +LLSAERAVTGY DPYT Q ISLFQAM+K+LI  
Sbjct: 1615 IDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVR 1674

Query: 3772 EEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSE-VRSYVDPSTD 3830
            E  +RLL+AQ+ATGGI+DP     +P++VAY+ GY +++ +  L++PS+  + + DP+T 
Sbjct: 1675 EHGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDEEMNRILADPSDDTKGFFDPNTH 1734

Query: 3831 ERLSYTQLLRRCRRDDGTGQLLLPL--------------------SDARKLTFRGLRKQI 3870
            E L+Y QLL RC  D  TG  LL +                      A+    R   + +
Sbjct: 1735 ENLTYLQLLERCVEDPETGLYLLQIIKKGENYVYINEATRHVLQSRTAKMRVGRFADQVV 1794

Query: 3871 TMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQA 3930
            +  +L+ S    E    + RE +      +  L+K LE       +     +E  +  Q 
Sbjct: 1795 SFWDLLSSPYFTED---RKRELIQEYGAQSGGLEKLLE-------IITTTIEETETQNQG 1844

Query: 3931 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT 3990
            +K   IR     E+  A      VID      L V       +   E     L     + 
Sbjct: 1845 IKVAAIRG----EVTAADLFNSRVIDQKTLHTLRVGRTGGQALSTLECVKPYLEGSDCIA 1900

Query: 3991 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF 4050
            G   P + +++SL +A +K LI       LLEAQ ATG ++DP    +L V+ A   GL 
Sbjct: 1901 GVTVPSTREVMSLHEASRKELIPAAFATWLLEAQAATGFLLDPCTRQKLSVDEAVDVGLV 1960

Query: 4051 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSS 4110
            +EE+ E L        G+ DP T + +   Q M++ + +    L LL             
Sbjct: 1961 NEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEALRLL------------- 2007

Query: 4111 KSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKS 4170
               V+     ++DP+    + +  AYR+G +    Y  +S+Q+   +     ++   V  
Sbjct: 2008 --EVQVATGGVIDPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSY 2065

Query: 4171 MIIDRRSGRQYD---IDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNAGGFRSRSSS 4227
              +  R   Q D   +   + K   D   +D      L     A+ +    G FR +  +
Sbjct: 2066 RELQERCRPQEDTGWVLFPVNKAARDSEHIDDETRRALE----AEQVEITVGRFRGQKPT 2121

Query: 4228 VGS--SSSYPISP------AVSRT----------QLASWSDPTEET--------GPVAGI 4261
            + +  +S Y           + RT          QL       +ET        G    I
Sbjct: 2122 LWALLNSEYVTEEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQI 2181

Query: 4262 LDTETLEKVSITEAM----------HRNLVDNITGQRLLEAQACTGGII-----DPSTGE 4306
              +E L    ITE M           + L+++   +R LE  +C  G++      P   E
Sbjct: 2182 TASELLSSAIITEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQE 2241

Query: 4307 RFPVTDAVNKG-------------------LVDKIMVDRINL------------------ 4329
            +  +  A+ KG                   ++D +   R+++                  
Sbjct: 2242 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLL 2301

Query: 4330 -AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDE 4388
             A++A  G+ DP T  ++S  QA++K  +  E G R LE Q  TGG+I+P    RVP+D 
Sbjct: 2302 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 2361

Query: 4389 ALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQS 4448
            A +RG  D    + L D    +K    P T   ++Y   L R + +  TGL +L+ A + 
Sbjct: 2362 AYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRG 2421

Query: 4449 T 4449
            +
Sbjct: 2422 S 2422



 Score = 1040 bits (2688), Expect = 0.0
 Identities = 679/1786 (38%), Positives = 979/1786 (54%), Gaps = 160/1786 (8%)

Query: 2750 RAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYR 2809
            R++ G     +GQ  S++ AM++GL+    G  LLEAQ ATGG++D      +PV  A +
Sbjct: 41   RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100

Query: 2810 RGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG 2869
            +G    E+   L      T G+ DP   E L   Q + + V D   G   L +  + A G
Sbjct: 101  QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEV--QLATG 158

Query: 2870 GELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINS-EYFTAEQRRDLLRQFRTGRI 2928
            G +      A+ V      +   G    +T   W  ++  E  T + R   L      R+
Sbjct: 159  GLV----DPAQGVLVAPEPACHQGLLDRET---WHKLSELEPGTGDLR--FLNPNTLERL 209

Query: 2929 TVEKIIKIIITVVEEQEQ--KGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR 2986
            T  ++++  +            ++ F  +   V AAELLE  ++D +  Q L+ G  +  
Sbjct: 210  TYHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQGLREGRLAAV 269

Query: 2987 DVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHII 3046
            DV+    VRR L G   +AGV L   G K S + A  + LLP   A+ LLEAQA T  ++
Sbjct: 270  DVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATHTLV 329

Query: 3047 DPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPRE 3106
            DP T  RL VDEAVRAGLV PE HE+LL AE+AVTG+ DP++G  + LFQA+KKGL+ R 
Sbjct: 330  DPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLVDRP 389

Query: 3107 QGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGE 3166
              LRLLDAQL+TGG+V P++  R+PL+ A   GCLDE+T R LS     A ++SD + G 
Sbjct: 390  LALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLS----QAGSFSDGTHGG 445

Query: 3167 PATYGELQQRCRPDQLTGLSLLPLSEKAARAR-QEELYSELQARETFEKTPVEVPVGGFK 3225
               Y +L   C  D  TGL+ LPLS        Q   + +   R+        V VG F+
Sbjct: 446  -LRYEQLLALCVTDPETGLAFLPLSGGPRGGEPQGPPFIKYSTRQALSTATATVSVGKFR 504

Query: 3226 GRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSG 3285
            GR V++WEL+ SE  ++EQR  L +Q++ G ++VEK+   L   +E+       R++FSG
Sbjct: 505  GRPVSLWELLFSEAISSEQRAMLAQQYQEGTLSVEKLAAELSATLEQAAATA--RVTFSG 562

Query: 3286 LRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKE 3345
            LR  V   ELL + ++ +  +E+L+ G+ T KD+  L S +  LQG+GC+AG+ L  ++E
Sbjct: 563  LRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGTGCIAGLLLPGSQE 622

Query: 3346 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL 3405
            ++SIYEA  +GLLR  TA +LLEAQAATGF++DP  N+   V EA++A V+GP++  +LL
Sbjct: 623  RLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALRAAVIGPDVFAKLL 682

Query: 3406 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV 3465
            SAE+AVTGY DPY+G  ISLFQAMQKGL++R+HGIRLLEAQIATGG+IDPVHSHRVPVDV
Sbjct: 683  SAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 742

Query: 3466 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE 3525
            AY+RGYF + +N +L DPSDDTKGFFDPNTHENLTY QLLERCV DPETGL LLPL   +
Sbjct: 743  AYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDPETGLYLLPLSSTQ 802

Query: 3526 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD 3585
               V        +  T++AF+   + +   G   G  +S WE++ S+   E +R QL+  
Sbjct: 803  SPLV--------DSATQQAFQNLLLSVK-YGRFQGQRVSAWELINSEYFSEGRRRQLLRR 853

Query: 3586 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR 3645
            ++   VT  ++  ++     + E  RQ  +     +R R+T   L EA II  +  + + 
Sbjct: 854  YRQREVTLGQVAKLL-----EAETQRQADI-MLPALRSRVTVHQLLEAGIIDQQLLDQVL 907

Query: 3646 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ 3705
             GT S    L  +    YL G G+V GV L  S Q LS+YQA+++ LL   VA  LLEAQ
Sbjct: 908  AGTISPEALLLMDGVRRYLCGLGAVGGVRLLPSGQRLSLYQAMRQKLLGPRVALALLEAQ 967

Query: 3706 AATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMK 3765
            AATG ++DP   E L+VDEAVR+G+VGPEL+ RL  AE A+ G+RDP++ + +S+FQAMK
Sbjct: 968  AATGTIMDPHSPESLSVDEAVRRGVVGPELYGRLKRAEGAIAGFRDPFSGKQVSVFQAMK 1027

Query: 3766 KELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSEVRSYV 3825
            K LIP E+A RLL+AQ+ATGGI+DP    HLP+ VA QRGY++++    LS  SE  ++ 
Sbjct: 1028 KGLIPWEQAARLLEAQVATGGIIDPTSHHHLPMPVAIQRGYVDQEMETALSSSSE--TFP 1085

Query: 3826 DPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDA-----------RKL-TFRGLRKQITME 3873
             P    R SY QLL  C RD+ +G  LLPL ++           R L    G +   ++ 
Sbjct: 1086 TPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPTEEQVQRSLQAVPGAKDGTSLW 1145

Query: 3874 ELVRSQVMDEATALQL----REGLTSIEEVTKNLQKFLEGTSCI---------------- 3913
            +L+ S    E     L    +EG T++ ++  ++Q++++ T  +                
Sbjct: 1146 DLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQRWVQETKLLAQARVMVPGPRGEVPA 1205

Query: 3914 -----AGVFVDATKERL--------------------------------------SVYQA 3930
                 AG+    T E L                                      S+ QA
Sbjct: 1206 VWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKACLWGTGCVAGVLLQPSGAKASIAQA 1265

Query: 3931 MKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVT 3990
            ++ G++  G    LLEAQ A+G+++DP+   +L+VE+AV++G+VG E  ++L  AERA  
Sbjct: 1266 VRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSVEDAVKVGLVGRELSEQLGQAERAAA 1325

Query: 3991 GYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLF 4050
            GY DPYS   +SL+QAM+KGL+ ++ G+ LL+ Q+ATGG++DP     LP   A + GL 
Sbjct: 1326 GYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQLATGGVVDPVHGVHLPQAAACRLGLL 1385

Query: 4051 DEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPL-KEKKRERKTS 4109
            D + +++LT    D K FFDP+  + +TY QL ERC+ D +TGL LLPL  +   E    
Sbjct: 1386 DTQTSQVLTAVDKDNKFFFDPSARDQVTYQQLRERCVCDSETGLLLLPLPSDTVLEVDDH 1445

Query: 4110 SKSSVRKRRV-VIVDPETGKEMSVYEAYRKGLIDHQTYLEL-----SEQECEWEEITISS 4163
            +  ++R  +V V      G  +S+++      +      EL     S +     ++ +S+
Sbjct: 1446 TAVALRAMKVPVSTGRFKGCSVSLWDLLLSEYVGADKRRELVALCRSGRAAALRQV-VSA 1504

Query: 4164 SDGVVKS------MIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGN 4217
               +V++          R   +Q    D     LI R  LD+   GT ++ E A+M    
Sbjct: 1505 VTALVEAAERQPLQATFRGLRKQVSARDLFRAQLISRKTLDELSQGTTTVKEVAEM---- 1560

Query: 4218 AGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMH 4277
                                 +V R+         E    +AG+L   T E++SI EA+ 
Sbjct: 1561 --------------------DSVKRS--------LEGGNFIAGVLIQGTQERMSIPEALR 1592

Query: 4278 RNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGF 4337
            R+++   T   LLEAQA TG IIDP+   +  V +A   G+  K    ++  A++A  G+
Sbjct: 1593 RHILRPGTALVLLEAQAATGFIIDPAENRKLTVEEAFKAGMFGKETYVKLLSAERAVTGY 1652

Query: 4338 EDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDA 4397
             DP T  ++S  QA++K  +  E G R LE Q  TGG+I+P    RVP+D A + G  D 
Sbjct: 1653 TDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGIIDPVHSHRVPVDVAYRCGYFDE 1712

Query: 4398 RTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLE 4443
               + L D    +K    P T   ++Y   L+R + +  TGL LL+
Sbjct: 1713 EMNRILADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLYLLQ 1758



 Score =  735 bits (1898), Expect = 0.0
 Identities = 653/2071 (31%), Positives = 970/2071 (46%), Gaps = 337/2071 (16%)

Query: 2558 RRQQEELLAE------ENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
            R  +EELLAE      +   L  +L  + E+   A     ++  ++    +  P GR   
Sbjct: 2547 RAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDARRGPREPGPAGRG-- 2604

Query: 2612 DGPAAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAE-ELQR-LAQGHTT--------- 2656
            DG +  ++ E   +G  ++ +A     R QE  +  A  E+QR   QG            
Sbjct: 2605 DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS 2664

Query: 2657 -VDELARREDVRHYLQGRSSIAGLL------LKATNEKLSV--YAALQRQLLSPGTALIL 2707
             + E  R E +  +  G   +  L+      ++ T E+LS   +  L+RQ+ +       
Sbjct: 2665 YLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSA------- 2717

Query: 2708 LEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQ----- 2762
              ++  +  +L P   R L       + V   +   + L     + G   P   Q     
Sbjct: 2718 --SELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQE 2775

Query: 2763 QISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLA 2822
            ++S++QAM KG++     + LLEAQ ATG VIDPV + R+ V+ A   G    E+   L 
Sbjct: 2776 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL 2835

Query: 2823 DPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDV 2882
                   G+ DP T + ++  Q +++ +   E G+ LL    + A GG +        D 
Sbjct: 2836 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA--QIATGGVI--------DP 2885

Query: 2883 FEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVE 2942
                 V       +G            YF  E  R L       +   +      +T V+
Sbjct: 2886 VHSHRVPVDVAYRRG------------YFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQ 2933

Query: 2943 EQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQ-QLQRGERSVRDVAEVDTVRRALRGA 3001
                        LR  VP          D  LY  QL     +V  ++E   +R ALR A
Sbjct: 2934 L-----------LRRCVPDP--------DTGLYMLQLAGRGSAVHQLSE--ELRCALRDA 2972

Query: 3002 NVIAGVWLEEAGQKLSIYNAL---------KKDLLPSDMAVALLEAQAGTGHIIDPATSA 3052
             V  G    + GQ +S++  L         ++DLL    A  L   + G   +      A
Sbjct: 2973 RVTPGSGALQ-GQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGAT-LTSLLAQA 3030

Query: 3053 RLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLL 3112
            +        AG   P+  E L +A   V   R    G++V ++  L  G +       LL
Sbjct: 3031 QAQARAEAEAGSPRPDPREALRAATMEVKVGR--LRGRAVPVWDVLASGYVSGAAREELL 3088

Query: 3113 DAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGE 3172
             A+  +G +  P+ + R+   +        EE   A  A      A+  P    PA  G+
Sbjct: 3089 -AEFGSGTLDLPALTRRLTAII--------EEAEEAPGARPQLQDAWRGPREPGPAGRGD 3139

Query: 3173 LQ--QRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVT 3230
                +  R  Q  G +    +  AA  RQE+         T     +EV  G F+GR V+
Sbjct: 3140 GDSGRSQREGQGEGETQEAAAAAAAARRQEQ---------TLRDATMEVQRGQFQGRPVS 3190

Query: 3231 VWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPV 3290
            VW+++ S Y +  +R ELL Q   G + +  ++ +L  ++EE E  R  ++SF GLR  V
Sbjct: 3191 VWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEE-RLSKVSFRGLRRQV 3249

Query: 3291 PASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLE-----DTKE 3345
             ASEL  SG+L       L  G  T+++++E+ SV+  L+G+ C+AG+ +        +E
Sbjct: 3250 SASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQE 3309

Query: 3346 KVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLL 3405
            K+SIY+AM +G+LR  TA +LLEAQAATGF++DPVRN RL V EAV AGVVG E+ E+LL
Sbjct: 3310 KMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLL 3369

Query: 3406 SAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDV 3465
            SAE+AVTGY DPY+G  ISLFQAMQK L++R+HGIRLLEAQIATGG+IDPVHSHRVPVDV
Sbjct: 3370 SAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV 3429

Query: 3466 AYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAE 3525
            AY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL RCV DP+TGL +L L G  
Sbjct: 3430 AYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQLAGRG 3489

Query: 3526 KAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMAD 3585
             A           EE R A  + ++  PG G+  G ++S+WE++    + E++R  L++ 
Sbjct: 3490 SA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVWELLFYREVSEDRRQDLLSR 3542

Query: 3586 FQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLR 3645
            ++AG +T E +   +  ++ + +             + R  A    EA     +    LR
Sbjct: 3543 YRAGTLTVEELGATLTSLLAQAQ------------AQARAEA----EAGSPRPDPREALR 3586

Query: 3646 EGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQ 3705
              T  ++               G + G  +P       ++  L  G +S   AR  L A+
Sbjct: 3587 AATMEVK--------------VGRLRGRAVP-------VWDVLASGYVSG-AAREELLAE 3624

Query: 3706 AATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER---AVTGYRDPYTEQTISL 3760
              +G L  P    RLT  ++EA       P+L D          A  G  D    Q    
Sbjct: 3625 FGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQ 3684

Query: 3761 FQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV--AYQRGYLNKDTHDQ--- 3814
             +   +E      A R  +  L    +   R  F   P+ V       YL++   D+   
Sbjct: 3685 GEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDELLA 3744

Query: 3815 --------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLTFRGL 3866
                    L +   V + V   T+ERLS                         K++FRGL
Sbjct: 3745 QHAAGALGLPDLVAVLTRVIEETEERLS-------------------------KVSFRGL 3779

Query: 3867 RKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQKFLEGTSCIAGVFVDA---- 3920
            R+Q++  EL  S ++   T   L +G  +++EVT+  +++++LEGTSCIAGV V A    
Sbjct: 3780 RRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQP 3839

Query: 3921 -TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFK 3979
              +E++S+YQAM KG++RPGTA  LLEAQAATG+VIDP++ L+L+VEEAV  G+VG E +
Sbjct: 3840 GRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQ 3899

Query: 3980 DKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRL 4039
            +KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 3900 EKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRV 3959

Query: 4040 PVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLLPL 4099
            PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTY+QL+ RC+ DP TGL +L L
Sbjct: 3960 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL 4019

Query: 4100 KEKKRERKTSSKSSVRKRRVVIVDPET----GKEMSVYEA--YRKGLIDHQTYLELSEQE 4153
              +       S+      R   V P +    G+ +SV+E   YR+   D +  L LS   
Sbjct: 4020 AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDL-LSRYR 4078

Query: 4154 CEWEEITISSSDGVVKSMI--------------------------------IDRRSGRQY 4181
                 +T+      + S++                                + R  GR  
Sbjct: 4079 A--STLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAV 4136

Query: 4182 DIDDAIAKNLIDRSA----LDQYRAGTLSITEFADMLS---------------------- 4215
             + D +A   + R+A    L ++ +GTL +      L+                      
Sbjct: 4137 PVWDVLASGYVSRAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRG 4196

Query: 4216 -----------GNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEET--GPVAGIL 4262
                       G++G  +      G +     + A +R Q  +  D T E   G   G  
Sbjct: 4197 PREPGPAGRGDGDSGRSQREGQGEGETQEAAAATAAARRQEQTLRDATMEVQRGQFQG-- 4254

Query: 4263 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGI-----------IDPSTGERFPVT 4311
                   VS+ + +  + +       LL AQ   G +           +   T ER  ++
Sbjct: 4255 -----RPVSVWDVLFSSYLSEARRDELL-AQHAAGALGLPDLVAVLTRVIEETEER--LS 4306

Query: 4312 DAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYL 4371
                +GL  ++    ++ +     G   P T   ++      +     ++ +R+LE    
Sbjct: 4307 KVSFRGLRRQVSASELHTS-----GILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSC 4361

Query: 4372 TGGLIEP--DTPGR---VPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKD 4426
              G++ P  D PGR   + + +A+ +G +   TA  L +  A + ++  P   L++S ++
Sbjct: 4362 IAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEE 4421

Query: 4427 ALDRSMVEEGTGLRLLEAAAQSTKGYYSPYS 4457
            A+   +V      +LL +A ++  GY  PY+
Sbjct: 4422 AVAAGVVGGEIQEKLL-SAERAVTGYTDPYT 4451



 Score =  727 bits (1876), Expect = 0.0
 Identities = 710/2292 (30%), Positives = 1038/2292 (45%), Gaps = 316/2292 (13%)

Query: 1903 EEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE-QAELEAARQRQLAAEEERRR 1961
            EE+ A   S    A  +A  E E G  R +  + LR+   + ++   R R +   +    
Sbjct: 3017 EELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPVWDVLAS 3076

Query: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-QLQLAQEA 2020
                   ++ L AE  +      AL    RL A +EEA       E   AR QLQ A   
Sbjct: 3077 GYVSGAAREELLAEFGSGTLDLPAL--TRRLTAIIEEAE------EAPGARPQLQDAWRG 3128

Query: 2021 AQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER 2080
             ++   A          Q+E + +   Q+  +        A AARR  +   +A ++ +R
Sbjct: 3129 PREPGPAGRGDGDSGRSQREGQGEGETQEAAAA-------AAAARRQEQTLRDATMEVQR 3181

Query: 2081 EAAQSR----------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130
               Q R            + EA R +  A+  A A       A  L +  E+   R ++ 
Sbjct: 3182 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAV-LTRVIEETEERLSKV 3240

Query: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2190
                LR +Q + +E+        +TLR  AQ  + L     ++ E D  K  L E    +
Sbjct: 3241 SFRGLR-RQVSASELHTSGILGPETLRDLAQGTKTLQ----EVTEMDSVKRYL-EGTSCI 3294

Query: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEK 2250
                  A  Q  + E+        M     +   +     AL+L +      F+ +    
Sbjct: 3295 AGVLVPAKDQPGRQEK--------MSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRN 3346

Query: 2251 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELL 2310
            ++   EEA    V   E                      ++EK+ + + A     +    
Sbjct: 3347 LRLSVEEAVAAGVVGGE----------------------IQEKLLSAERAVTGYTDPYTG 3384

Query: 2311 QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM 2370
            QQ   ++  QA         M + L     G  R LEA    Q+      + +      +
Sbjct: 3385 QQ---ISLFQA---------MQKDLIVREHGI-RLLEA----QIATGGVIDPVHSHRVPV 3427

Query: 2371 SRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2430
              A  R   D +  R  A+   +     +  T E +T VQ L  +R   D D       +
Sbjct: 3428 DVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLL--RRCVPDPDTGLYMLQL 3485

Query: 2431 AELEREKEKLQQEAK--LLQLKSEEMQTVQQEQLLQETQALQQSFLSE--KDSLLQRERF 2486
            A       +L +E +  L   +        Q Q +   + L    +SE  +  LL R R 
Sbjct: 3486 AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRA 3545

Query: 2487 IEQEKAKLEQLFQDEVAKAQ-QLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR 2545
                  +L       +A+AQ Q R E +    + +       A+ME    R       V 
Sbjct: 3546 GTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGRLRGRAVPV- 3604

Query: 2546 RKQEELQQLEQQRRQQEELLAE------ENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599
               + L         +EELLAE      +   L  +L  + E+   A     ++  +   
Sbjct: 3605 --WDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRG 3662

Query: 2600 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQ----RLQEAGILSAE-ELQR-LAQG 2653
              +  P GR   DG +  ++ E   +G  ++ +A     R QE  +  A  E+QR   QG
Sbjct: 3663 PREPGPAGRG--DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQG 3720

Query: 2654 HTT----------VDELARREDVRHYLQGRSSIAGLL------LKATNEKLSV--YAALQ 2695
                         + E  R E +  +  G   +  L+      ++ T E+LS   +  L+
Sbjct: 3721 RPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 3780

Query: 2696 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2755
            RQ+ +         ++  +  +L P   R L       + V   +   + L     + G 
Sbjct: 3781 RQVSA---------SELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 3831

Query: 2756 KDPYTGQ-----QISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRR 2810
              P   Q     ++S++QAM KG++     + LLEAQ ATG VIDPV + R+ V+ A   
Sbjct: 3832 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 3891

Query: 2811 GYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGG 2870
            G    E+   L        G+ DP T + ++  Q +++ +   E G+ LL    + A GG
Sbjct: 3892 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEA--QIATGG 3949

Query: 2871 ELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITV 2930
             +        D      V       +G            YF  E  R L       +   
Sbjct: 3950 VI--------DPVHSHRVPVDVAYRRG------------YFDEEMNRVLADPSDDTKGFF 3989

Query: 2931 EKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQ-QLQRGERSVRDVA 2989
            +      +T V+            LR  VP          D  LY  QL     +V  ++
Sbjct: 3990 DPNTHENLTYVQL-----------LRRCVPDP--------DTGLYMLQLAGRGSAVHQLS 4030

Query: 2990 EVDTVRRALRGANVIAGVWLEEAGQKLSIYNAL---------KKDLLPSDMAVALLEAQA 3040
            E   +R ALR A V  G    + GQ +S++  L         ++DLL    A  L   + 
Sbjct: 4031 E--ELRCALRDARVTPGSGALQ-GQSVSVWELLFYREVSEDRRQDLLSRYRASTLTVEEL 4087

Query: 3041 GTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKK 3100
            G   +      A+        AG   P+  E L +A   V   R    G++V ++  L  
Sbjct: 4088 GAT-LTSLLAQAQAQARAEAEAGSPRPDPREALRAATMEVKVGR--LRGRAVPVWDVLAS 4144

Query: 3101 GLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYS 3160
            G + R     LL A+  +G +  P+ + R+   +        EE   A  A      A+ 
Sbjct: 4145 GYVSRAAREELL-AEFGSGTLDLPALTRRLTAII--------EEAEEAPGARPQLQDAWR 4195

Query: 3161 DPSTGEPATYGELQ--QRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVE 3218
             P    PA  G+    +  R  Q  G +    +  AA  RQE+         T     +E
Sbjct: 4196 GPREPGPAGRGDGDSGRSQREGQGEGETQEAAAATAAARRQEQ---------TLRDATME 4246

Query: 3219 VPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQ 3278
            V  G F+GR V+VW+++ S Y +  +R ELL Q   G + +  ++ +L  ++EE E  R 
Sbjct: 4247 VQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEE-RL 4305

Query: 3279 ERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGI 3338
             ++SF GLR  V ASEL  SG+L       L  G  T+++++E+ SV+  L+G+ C+AG+
Sbjct: 4306 SKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGV 4365

Query: 3339 YLE-----DTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKA 3393
             +        +EK+SIY+AM +G+LR  TA +LLEAQAATGF++DPVRN RL V EAV A
Sbjct: 4366 LVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAA 4425

Query: 3394 GVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGII 3453
            GVVG E+ E+LLSAE+AVTGY DPY+G  ISLFQAMQK L++R+HGIRLLEAQIATGG+I
Sbjct: 4426 GVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVI 4485

Query: 3454 DPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPE 3513
            DPVHSHRVPVDVAY+RGYF EEMNRVLADPSDDTKGFFDPNTHENLTY QLL RCV DP+
Sbjct: 4486 DPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPD 4545

Query: 3514 TGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDL 3573
            TGL +L L G   A           EE R A  + ++  PG G+  G ++S+WE++    
Sbjct: 4546 TGLYMLQLAGRGSA------VHQLSEELRCALRDARV-TPGSGALQGQSVSVWELLFYRE 4598

Query: 3574 IPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEA 3633
            + E++R  L++ ++AG +T E +   +  ++ + +             + R  A    EA
Sbjct: 4599 VSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQ------------AQARAEA----EA 4642

Query: 3634 RIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLL 3693
                 +    LR  T  ++               G + G  +P       ++  L  G +
Sbjct: 4643 GSPRPDPREALRAATMEVK--------------VGRLRGRAVP-------VWDVLASGYV 4681

Query: 3694 SAEVARLLLEAQAATGFLLDPVKGERLT--VDEAVRKGLVGPELHDRLLSAER---AVTG 3748
            S   AR  L A+  +G L  P    RLT  ++EA       P+L D          A  G
Sbjct: 4682 SG-AAREELLAEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRG 4740

Query: 3749 YRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFH-LPLEV--AYQRG 3805
              D    Q     +   +E      A R  +  L    +   R  F   P+ V       
Sbjct: 4741 DGDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS 4800

Query: 3806 YLNKDTHDQ-----------LSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLP 3854
            YL++   D+           L +   V + V   T+ERLS                    
Sbjct: 4801 YLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLS-------------------- 4840

Query: 3855 LSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTK--NLQKFLEGTSC 3912
                 K++FRGLR+Q++  EL  S ++   T   L +G  +++EVT+  +++++LEGTSC
Sbjct: 4841 -----KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSC 4895

Query: 3913 IAGVFVDA-----TKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEE 3967
            IAGV V A      +E++S+YQAM KG++RPGTA  LLEAQAATG+VIDP++ L+L+VEE
Sbjct: 4896 IAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEE 4955

Query: 3968 AVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIAT 4027
            AV  G+VG E ++KLLSAERAVTGY DPY+G+ ISLFQAM+K LI+++HGIRLLEAQIAT
Sbjct: 4956 AVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIAT 5015

Query: 4028 GGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCI 4087
            GG+IDP  SHR+PV+VAY+RG FDEEMN +L DPSDDTKGFFDPNT ENLTYLQL++R  
Sbjct: 5016 GGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRAT 5075

Query: 4088 TDPQTGLCLLPL 4099
             DP+TGL  L L
Sbjct: 5076 LDPETGLLFLSL 5087



 Score =  546 bits (1406), Expect = e-154
 Identities = 434/1449 (29%), Positives = 677/1449 (46%), Gaps = 192/1449 (13%)

Query: 3078 KAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACA 3137
            +++ G     +GQ+ S++ A+++GL+P   G  LL+AQ +TGG+VD ++   +P+  A  
Sbjct: 41   RSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKALQ 100

Query: 3138 RGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPL------- 3190
            +G +  E    L A       Y DP  GE     +   +   D+  G S L +       
Sbjct: 101  QGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGGL 160

Query: 3191 ---SEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3247
               ++    A +   +  L  RET+ K                   L   E  T + R  
Sbjct: 161  VDPAQGVLVAPEPACHQGLLDRETWHK-------------------LSELEPGTGDLR-- 199

Query: 3248 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3307
             L      ++T  ++++  +        L   +++F  +   V A+ELL  G+L     +
Sbjct: 200  FLNPNTLERLTYHQLLERCVRAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQ 259

Query: 3308 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3367
             L++G+    D+S    VR  L+G+G +AG+ L     K S ++A    LL   TA  LL
Sbjct: 260  GLREGRLAAVDVSARAEVRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLL 319

Query: 3368 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3427
            EAQAAT  LVDP+  QRL+V EAV+AG+V PELHEQLL AE+AVTG+ DP+SGS I LFQ
Sbjct: 320  EAQAATHTLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQ 379

Query: 3428 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3487
            AM+KGLV R   +RLL+AQ+ATGG++ P    R+P++ A + G   E+  R L+      
Sbjct: 380  AMKKGLVDRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQA---- 435

Query: 3488 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3547
             G F   TH  L Y QLL  CV DPETGL  LPL G  +    +    + +  TR+A   
Sbjct: 436  -GSFSDGTHGGLRYEQLLALCVTDPETGLAFLPLSGGPRGGEPQGPP-FIKYSTRQALST 493

Query: 3548 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKT 3607
                +   G   G  +SLWE++ S+ I  EQRA L   +Q G ++ E++   +   +E+ 
Sbjct: 494  ATATV-SVGKFRGRPVSLWELLFSEAISSEQRAMLAQQYQEGTLSVEKLAAELSATLEQA 552

Query: 3608 EIIRQQGLASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGT 3667
                +    ++  +R  +T  +L +A II  + Y  L  G  + ++     SA  YL GT
Sbjct: 553  AATAR---VTFSGLRDTVTPGELLKAEIIDQDLYERLEHGQATAKDVGSLASAQRYLQGT 609

Query: 3668 GSVAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVR 3727
            G +AG+ LPGS++ LSIY+A  KGLL    A +LLEAQAATGF++DP   +  +V+EA+R
Sbjct: 610  GCIAGLLLPGSQERLSIYEARCKGLLRPGTALILLEAQAATGFIIDPKANKGHSVEEALR 669

Query: 3728 KGLVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGI 3787
              ++GP++  +LLSAERAVTGY DPYT Q ISLFQAM+K LI  E  +RLL+AQ+ATGG+
Sbjct: 670  AAVIGPDVFAKLLSAERAVTGYTDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGV 729

Query: 3788 VDPRLGFHLPLEVAYQRGYLNKDTHDQLSEPSE-VRSYVDPSTDERLSYTQLLRRCRRDD 3846
            +DP     +P++VAY+RGY ++  +  L +PS+  + + DP+T E L+Y QLL RC RD 
Sbjct: 730  IDPVHSHRVPVDVAYRRGYFDQMLNLILLDPSDDTKGFFDPNTHENLTYLQLLERCVRDP 789

Query: 3847 GTGQLLLPLSD--------ARKLTFRGLR----------KQITMEELVRSQVMDEATALQ 3888
             TG  LLPLS         A +  F+ L           ++++  EL+ S+   E    Q
Sbjct: 790  ETGLYLLPLSSTQSPLVDSATQQAFQNLLLSVKYGRFQGQRVSAWELINSEYFSEGRRRQ 849

Query: 3889 LREGLTSIEEVTKNLQKFLEG-TSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEA 3947
            L       E     + K LE  T   A + + A + R++V+Q ++ GII         + 
Sbjct: 850  LLRRYRQREVTLGQVAKLLEAETQRQADIMLPALRSRVTVHQLLEAGII---------DQ 900

Query: 3948 QAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAM 4007
            Q     +   I    L + + VR          + L    AV G +   SG+ +SL+QAM
Sbjct: 901  QLLDQVLAGTISPEALLLMDGVR----------RYLCGLGAVGGVRLLPSGQRLSLYQAM 950

Query: 4008 KKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKG 4067
            ++ L+     + LLEAQ ATG I+D                                   
Sbjct: 951  RQKLLGPRVALALLEAQAATGTIMD----------------------------------- 975

Query: 4068 FFDPNTEENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETG 4127
               P++ E+L+  + + R +  P+           + +R   + +  R       DP +G
Sbjct: 976  ---PHSPESLSVDEAVRRGVVGPEL--------YGRLKRAEGAIAGFR-------DPFSG 1017

Query: 4128 KEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAI 4187
            K++SV++A +KGLI              WE+        V    IID  S     +  AI
Sbjct: 1018 KQVSVFQAMKKGLIP-------------WEQAARLLEAQVATGGIIDPTSHHHLPMPVAI 1064

Query: 4188 AKNLIDRSALDQYRAGTLSI--------TEFADMLSGNAGGFRSRSSSVGSSSSYPISPA 4239
             +  +D+       + + +         T +A +L        S    +    S P  P 
Sbjct: 1065 QRGYVDQEMETALSSSSETFPTPDGQGRTSYAQLLEECPRDETSGLHLLPLPESAPALPT 1124

Query: 4240 VSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG-- 4297
              + Q +  + P    G   G    + L     TE   R L++++   R    Q      
Sbjct: 1125 EEQVQRSLQAVP----GAKDGTSLWDLLSSCHFTEEQRRGLLEDVQEGRTTVPQLLASVQ 1180

Query: 4298 ------------GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGF-EDPRTKT 4344
                         ++ P      P    ++ G++ +  ++ +    ++     E P  K 
Sbjct: 1181 RWVQETKLLAQARVMVPGPRGEVPAVWLLDAGIITQETLEALAQGTQSPAQVAEQPAVKA 1240

Query: 4345 ------------------KMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPL 4386
                              K S AQA++ G L    GQR LE Q  +G L++P    R+ +
Sbjct: 1241 CLWGTGCVAGVLLQPSGAKASIAQAVRDGLLPTGLGQRLLEAQVASGFLVDPLNNQRLSV 1300

Query: 4387 DEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAA 4446
            ++A++ G V    +++L      +     P ++  +S   A+++ +V +  GL LL+   
Sbjct: 1301 EDAVKVGLVGRELSEQLGQAERAAAGYPDPYSRASLSLWQAMEKGLVPQNEGLPLLQVQL 1360

Query: 4447 QSTKGYYSP 4455
             +T G   P
Sbjct: 1361 -ATGGVVDP 1368



 Score =  459 bits (1182), Expect = e-128
 Identities = 444/1446 (30%), Positives = 666/1446 (46%), Gaps = 242/1446 (16%)

Query: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
            + +++ Q E E Q   A+   ARR+    E+ +R    E+Q+ + Q R         +  
Sbjct: 2610 RSQREGQGEGETQEAAAAAAAARRQ----EQTLRDATMEVQRGQFQGRPVSVWDVLFSSY 2665

Query: 2572 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP---EHSFDGLR 2628
            L E             A  +E+ A   A    LP+    L     E E    + SF GLR
Sbjct: 2666 LSE-------------ARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 2712

Query: 2629 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN--- 2685
            R+VSA  L  +GIL  E L+ LAQG  T+ E+   + V+ YL+G S IAG+L+ A +   
Sbjct: 2713 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 2772

Query: 2686 --EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHH 2743
              EK+S+Y A+ + +L PGTAL+LLEAQAA+GF++DPVRN RL+V EAV  GVVG E+  
Sbjct: 2773 RQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQE 2832

Query: 2744 KLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2803
            KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVP
Sbjct: 2833 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2892

Query: 2804 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLT 2863
            VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTY+QLL RCV DP+TGL +L L 
Sbjct: 2893 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL- 2951

Query: 2864 DKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQF 2923
              A +G  +     E R     A V+   G  QG++V++WE++     + ++R+DLL ++
Sbjct: 2952 --AGRGSAVHQLSEELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRY 3009

Query: 2924 RTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGER 2983
            R G +TVE++   + +++ + + + R            AE    R   RE  +       
Sbjct: 3010 RAGTLTVEELGATLTSLLAQAQAQAR----------AEAEAGSPRPDPREALR------- 3052

Query: 2984 SVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTG 3043
                 A ++     LRG  V   VW   A   +S   A +++LL          A+ G+G
Sbjct: 3053 ----AATMEVKVGRLRGRAV--PVWDVLASGYVS--GAAREELL----------AEFGSG 3094

Query: 3044 HIIDPATSARLT--VDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKG 3101
             +  PA + RLT  ++EA  A    P+               +D + G            
Sbjct: 3095 TLDLPALTRRLTAIIEEAEEAPGARPQL--------------QDAWRG------------ 3128

Query: 3102 LIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSD 3161
              PRE G        +  G  D  +S R         G  + ET  A +A    A A   
Sbjct: 3129 --PREPG-------PAGRGDGDSGRSQR--------EGQGEGETQEAAAAA---AAARRQ 3168

Query: 3162 PSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQA------------R 3209
              T   AT  E+Q+     +   +  +  S   + AR++EL ++  A             
Sbjct: 3169 EQTLRDATM-EVQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLT 3227

Query: 3210 ETFEKTPVEVPVGGFKG--RTVTVWELISSEYFTAEQRQELLRQFRT-GKVT-VEKVIKI 3265
               E+T   +    F+G  R V+  EL +S     E  ++L +  +T  +VT ++ V + 
Sbjct: 3228 RVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRY 3287

Query: 3266 L--------ITIVEEVETLRQERLS-----FSGLRAPVPASELLASGVLSRAQFEQLKDG 3312
            L        + +  + +  RQE++S     + G+  P  A  LL +   +    + +++ 
Sbjct: 3288 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 3347

Query: 3313 KTTVKDLSELGSV-----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3367
            + +V++    G V       LL     + G     T +++S+++AM++ L+       LL
Sbjct: 3348 RLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 3407

Query: 3368 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3427
            EAQ ATG ++DPV + R+ V  A + G    E++  L        G+ DP +   ++  Q
Sbjct: 3408 EAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQ 3467

Query: 3428 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLAD----P 3483
             +++ +     G+ +L  Q+A  G    VH               SEE+   L D    P
Sbjct: 3468 LLRRCVPDPDTGLYML--QLAGRG--SAVHQ-------------LSEELRCALRDARVTP 3510

Query: 3484 SDDTKGFFDPNTHENLTYRQLLERCVED------------PETGLRLLPLKGAEKAEV-V 3530
                      +  E L YR++ E   +D             E G  L  L    +A+   
Sbjct: 3511 GSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARA 3570

Query: 3531 ETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGR 3590
            E        + R A     +++  G    G  + +W+V+ S  +    R +L+A+F +G 
Sbjct: 3571 EAEAGSPRPDPREALRAATMEVKVGRLR-GRAVPVWDVLASGYVSGAAREELLAEFGSGT 3629

Query: 3591 V---TKERMIIIIIEIIEKTEIIRQQ--------------GLASYDYVRRRL------TA 3627
            +      R +  IIE  E+    R Q              G    D  R +         
Sbjct: 3630 LDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGET 3689

Query: 3628 EDLFEARIISLETYNLLREGTRSLREAL---EAESAWCYLYGTGSVAGVYLPGSR--QTL 3682
            ++   A   +      LR+ T  ++         S W  L+ +      YL  +R  + L
Sbjct: 3690 QEAAAAAAAARRQEQTLRDATMEVQRGQFQGRPVSVWDVLFSS------YLSEARRDELL 3743

Query: 3683 SIYQALKKGL--LSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE-LHD-- 3737
            + + A   GL  L A + R++ E +     +       +++  E    G++GPE L D  
Sbjct: 3744 AQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLA 3803

Query: 3738 ----------------RLLSAERAVTGYRDPYTEQ-----TISLFQAMKKELIPTEEALR 3776
                            R L     + G   P  +Q      +S++QAM K ++    AL 
Sbjct: 3804 QGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALV 3863

Query: 3777 LLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQ-LSEPSEVRSYVDPSTDERLSY 3835
            LL+AQ ATG ++DP     L +E A   G +  +  ++ LS    V  Y DP T +++S 
Sbjct: 3864 LLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISL 3923

Query: 3836 TQLLRR 3841
             Q +++
Sbjct: 3924 FQAMQK 3929



 Score =  446 bits (1147), Expect = e-124
 Identities = 449/1552 (28%), Positives = 699/1552 (45%), Gaps = 266/1552 (17%)

Query: 2440 LQQEAKLLQLKSEEMQTVQQEQLLQET----QALQQSFLSEKDSLLQRERFIEQEKAKLE 2495
            + +E +   LK+E   T  ++    +T    QA+Q+  + + ++L    R +E + A   
Sbjct: 1960 VNEELRERLLKAERAATGYRDPATGDTIPLFQAMQKQLIEKAEAL----RLLEVQVATGG 2015

Query: 2496 QLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
             +   +     +L  E   ++  + ++   L++  +  R+R  +     +    ELQ+  
Sbjct: 2016 VI---DPQHHHRLPLETAYRRGCLHKDIYALISDQKHMRKRFVDPNTQEKVSYRELQERC 2072

Query: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL----------- 2604
            + +     +L   N+  R+   + +E  RA  A   E+T  +    K             
Sbjct: 2073 RPQEDTGWVLFPVNKAARDSEHIDDETRRALEAEQVEITVGRFRGQKPTLWALLNSEYVT 2132

Query: 2605 ------------PNGRDALDGPA---------AEAEPEHS-FDGLRRKVSAQRLQEAGIL 2642
                         + R AL   A          E   +H  F G+RR+++A  L  + I+
Sbjct: 2133 EEKKLQLVRMYRTHTRRALQTVAQLILELIEKQETSNKHLWFQGIRRQITASELLSSAII 2192

Query: 2643 SAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN-----EKLSVYAALQRQ 2697
            + E LQ L  G +T  EL   + V+ YL+G S IAG+L+ A +     EK+S+Y A+ + 
Sbjct: 2193 TEEMLQDLETGRSTTQELMEDDRVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKG 2252

Query: 2698 LLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKD 2757
            +L PGTAL+LLEAQAA+GF++DPVRN RL+V E V  GVVG E+  KLLSAERAVTGY D
Sbjct: 2253 VLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEPVPAGVVGSEIQEKLLSAERAVTGYTD 2312

Query: 2758 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM 2817
            PYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM
Sbjct: 2313 PYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEM 2372

Query: 2818 NRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDS 2877
            NRVLADPSDDTKGFFDPNTHENLTY+QLL RCV DP+TGL +L L   A +G  +     
Sbjct: 2373 NRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLYMLQL---AGRGSAVHQLSE 2429

Query: 2878 EARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKII 2937
            E R     A V+   G  QG++V++WE++     + ++R+DLL ++R G +TVE++   +
Sbjct: 2430 ELRCALRDARVTPGSGALQGQSVSVWELLFYREVSEDRRQDLLSRYRAGTLTVEELGATL 2489

Query: 2938 ITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRA 2997
             +++ + + + R            AE    R   RE  +            A ++     
Sbjct: 2490 TSLLAQAQAQAR----------AEAEAGSPRPDPREALR-----------AATMEVKVGR 2528

Query: 2998 LRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLT-- 3055
            LRG  V   VW   A   +S   A +++LL          A+ G+G +  PA + RLT  
Sbjct: 2529 LRGRAV--PVWDVLASGYVS--RAAREELL----------AEFGSGTLDLPALTRRLTAI 2574

Query: 3056 VDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQ 3115
            ++EA  A    P+                           Q  ++G  PRE G       
Sbjct: 2575 IEEAEEAPGARPQ--------------------------LQDARRG--PREPG------- 2599

Query: 3116 LSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQ 3175
             +  G  D  +S R         G  + ET  A +A    A A     T   AT  E+Q+
Sbjct: 2600 PAGRGDGDSGRSQR--------EGQGEGETQEAAAAA---AAARRQEQTLRDATM-EVQR 2647

Query: 3176 RCRPDQLTGLSLLPLSEKAARARQEELYSELQA------------RETFEKTPVEVPVGG 3223
                 +   +  +  S   + AR++EL ++  A                E+T   +    
Sbjct: 2648 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVS 2707

Query: 3224 FKG--RTVTVWELISSEYFTAEQRQELLRQFRT-GKVT-VEKVIKIL--------ITIVE 3271
            F+G  R V+  EL +S     E  ++L +  +T  +VT ++ V + L        + +  
Sbjct: 2708 FRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPA 2767

Query: 3272 EVETLRQERLS-----FSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSV- 3325
            + +  RQE++S     + G+  P  A  LL +   +    + +++ + +V++    G V 
Sbjct: 2768 KDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVG 2827

Query: 3326 ----RTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVR 3381
                  LL     + G     T +++S+++AM++ L+       LLEAQ ATG ++DPV 
Sbjct: 2828 GEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVH 2887

Query: 3382 NQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIR 3441
            + R+ V  A + G    E++  L        G+ DP +   ++  Q +++ +     G+ 
Sbjct: 2888 SHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVPDPDTGLY 2947

Query: 3442 LLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLAD----PSDDTKGFFDPNTHE 3497
            +L  Q+A  G    VH               SEE+   L D    P          +  E
Sbjct: 2948 ML--QLAGRG--SAVHQ-------------LSEELRCALRDARVTPGSGALQGQSVSVWE 2990

Query: 3498 NLTYRQLLERCVED------------PETGLRLLPLKGAEKAEV-VETTQVYTEEETRRA 3544
             L YR++ E   +D             E G  L  L    +A+   E        + R A
Sbjct: 2991 LLFYREVSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAEAGSPRPDPREA 3050

Query: 3545 FEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRV---TKERMIIIII 3601
                 +++  G    G  + +W+V+ S  +    R +L+A+F +G +      R +  II
Sbjct: 3051 LRAATMEVKVGRLR-GRAVPVWDVLASGYVSGAAREELLAEFGSGTLDLPALTRRLTAII 3109

Query: 3602 EIIEKTEIIRQQ--------------GLASYDYVRRRL------TAEDLFEARIISLETY 3641
            E  E+    R Q              G    D  R +         ++   A   +    
Sbjct: 3110 EEAEEAPGARPQLQDAWRGPREPGPAGRGDGDSGRSQREGQGEGETQEAAAAAAAARRQE 3169

Query: 3642 NLLREGTRSLREAL---EAESAWCYLYGTGSVAGVYLPGSR--QTLSIYQALKKGL--LS 3694
              LR+ T  ++         S W  L+ +      YL  +R  + L+ + A   GL  L 
Sbjct: 3170 QTLRDATMEVQRGQFQGRPVSVWDVLFSS------YLSEARRDELLAQHAAGALGLPDLV 3223

Query: 3695 AEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE-LHD---------------- 3737
            A + R++ E +     +       +++  E    G++GPE L D                
Sbjct: 3224 AVLTRVIEETEERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDS 3283

Query: 3738 --RLLSAERAVTGYRDPYTEQ-----TISLFQAMKKELIPTEEALRLLDAQLATGGIVDP 3790
              R L     + G   P  +Q      +S++QAM K ++    AL LL+AQ ATG ++DP
Sbjct: 3284 VKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDP 3343

Query: 3791 RLGFHLPLEVAYQRGYLNKDTHDQ-LSEPSEVRSYVDPSTDERLSYTQLLRR 3841
                 L +E A   G +  +  ++ LS    V  Y DP T +++S  Q +++
Sbjct: 3344 VRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQK 3395



 Score =  350 bits (897), Expect = 2e-95
 Identities = 286/925 (30%), Positives = 449/925 (48%), Gaps = 106/925 (11%)

Query: 2886 ATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQE 2945
            AT+    G+FQG+ V++W+++ S Y +  +R +LL Q   G + +  ++ ++  V+EE E
Sbjct: 4243 ATMEVQRGQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETE 4302

Query: 2946 QK-GRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVI 3004
            ++  ++ F GLR  V A+EL  S ++  E  + L +G +++++V E+D+V+R L G + I
Sbjct: 4303 ERLSKVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCI 4362

Query: 3005 AGVWLEEAGQ-----KLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEA 3059
            AGV +    Q     K+SIY A+ K +L    A+ LLEAQA TG +IDP  + RL+V+EA
Sbjct: 4363 AGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEA 4422

Query: 3060 VRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTG 3119
            V AG+VG E  EKLLSAE+AVTGY DPYTGQ +SLFQA++K LI RE G+RLL+AQ++TG
Sbjct: 4423 VAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATG 4482

Query: 3120 GIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRP 3179
            G++DP  SHRVP+DVA  RG  DEE +R L+ P  D K + DP+T E  TY +L +RC P
Sbjct: 4483 GVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYVQLLRRCVP 4542

Query: 3180 DQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEY 3239
            D  TGL +L L+ + +   Q  L  EL+         V    G  +G++V+VWEL+    
Sbjct: 4543 DPDTGLYMLQLAGRGSAVHQ--LSEELRC--ALRDARVTPGSGALQGQSVSVWELLFYRE 4598

Query: 3240 FTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG 3299
             + ++RQ+LL ++R G +TVE++   L +++ + +   +     +G   P P   L    
Sbjct: 4599 VSEDRRQDLLSRYRAGTLTVEELGATLTSLLAQAQAQARAEAE-AGSPRPDPREAL---- 4653

Query: 3300 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3359
               RA   ++K G+               L+G               V +++ +  G + 
Sbjct: 4654 ---RAATMEVKVGR---------------LRGRA-------------VPVWDVLASGYVS 4682

Query: 3360 ATTAALLLEAQAATGFLVDPVRNQRL--YVHEAVKAGVVGPELHEQLLSA-EKAVTGYRD 3416
                  LL A+  +G L  P   +RL   + EA +A    P+L +      E    G  D
Sbjct: 4683 GAAREELL-AEFGSGTLDLPALTRRLTAIIEEAEEAPGARPQLQDAWRGPREPGPAGRGD 4741

Query: 3417 PYSGSTISLFQ---------AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAY 3467
              SG +    Q         A       ++  +R    ++  G          V V    
Sbjct: 4742 GDSGRSQREGQGEGETQEAAAAAAAARRQEQTLRDATMEVQRGQF----QGRPVSVWDVL 4797

Query: 3468 QRGYFSE-EMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEK 3526
               Y SE   + +LA  +    G  D           +L R +E+ E  L  +  +G  +
Sbjct: 4798 FSSYLSEARRDELLAQHAAGALGLPD--------LVAVLTRVIEETEERLSKVSFRGLRR 4849

Query: 3527 AEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLMADF 3586
               V  ++++T         ET  D+  G      T +L EV + D +            
Sbjct: 4850 Q--VSASELHTSGILG---PETLRDLAQG------TKTLQEVTEMDSVK----------- 4887

Query: 3587 QAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDY----VRRRLTAEDLFEARIISLETYN 3642
               R  +    I  + +  K +  RQ+ ++ Y      V R  TA  L EA+  +    +
Sbjct: 4888 ---RYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVID 4944

Query: 3643 LLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3697
             +R    S+ EA+ A     E     L    +V G   P + Q +S++QA++K L+  E 
Sbjct: 4945 PVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREH 5004

Query: 3698 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVTGYRDPYTEQT 3757
               LLEAQ ATG ++DPV   R+ VD A R+G    E++  L        G+ DP T + 
Sbjct: 5005 GIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHEN 5064

Query: 3758 ISLFQAMKKELIPTEEALRLLDAQL 3782
            ++  Q +++  +  E  L  L   L
Sbjct: 5065 LTYLQLLQRATLDPETGLLFLSLSL 5089



 Score =  347 bits (889), Expect = 2e-94
 Identities = 202/360 (56%), Positives = 242/360 (67%), Gaps = 25/360 (6%)

Query: 2512 QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
            + +++ Q E E Q   A+   ARR+    E+ +R    E+Q+ + Q R         +  
Sbjct: 4746 RSQREGQGEGETQEAAAAAAAARRQ----EQTLRDATMEVQRGQFQGRPVSVWDVLFSSY 4801

Query: 2572 LREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP---EHSFDGLR 2628
            L E             A  +E+ A   A    LP+    L     E E    + SF GLR
Sbjct: 4802 LSE-------------ARRDELLAQHAAGALGLPDLVAVLTRVIEETEERLSKVSFRGLR 4848

Query: 2629 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATN--- 2685
            R+VSA  L  +GIL  E L+ LAQG  T+ E+   + V+ YL+G S IAG+L+ A +   
Sbjct: 4849 RQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLVPAKDQPG 4908

Query: 2686 --EKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHH 2743
              EK+S+Y A+ + +L PGTAL+LLEAQAA+GF++DPVRN RL+V EAV  GVVG E+  
Sbjct: 4909 RQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGVVGGEIQE 4968

Query: 2744 KLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVP 2803
            KLLSAERAVTGY DPYTGQQISLFQAMQK LIVREHGIRLLEAQIATGGVIDPVHSHRVP
Sbjct: 4969 KLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVP 5028

Query: 2804 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLT 2863
            VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLL+R   DPETGL  L L+
Sbjct: 5029 VDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLS 5088



 Score =  254 bits (648), Expect = 2e-66
 Identities = 137/307 (44%), Positives = 206/307 (67%), Gaps = 8/307 (2%)

Query: 3556 GSHGGSTMSLWEVMQSDLIPEEQRAQLMADFQAGRVTKERMIIIIIEIIEKTEIIRQQGL 3615
            G   G  +S+W+V+ S  + E +R +L+A   AG +    ++ ++  +IE+TE   +   
Sbjct: 4784 GQFQGRPVSVWDVLFSSYLSEARRDELLAQHAAGALGLPDLVAVLTRVIEETE--ERLSK 4841

Query: 3616 ASYDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYL 3675
             S+  +RR+++A +L  + I+  ET   L +GT++L+E  E +S   YL GT  +AGV +
Sbjct: 4842 VSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRYLEGTSCIAGVLV 4901

Query: 3676 P-----GSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGL 3730
            P     G ++ +SIYQA+ KG+L    A +LLEAQAATGF++DPV+  RL+V+EAV  G+
Sbjct: 4902 PAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNLRLSVEEAVAAGV 4961

Query: 3731 VGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDP 3790
            VG E+ ++LLSAERAVTGY DPYT Q ISLFQAM+K+LI  E  +RLL+AQ+ATGG++DP
Sbjct: 4962 VGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDP 5021

Query: 3791 RLGFHLPLEVAYQRGYLNKDTHDQLSEPS-EVRSYVDPSTDERLSYTQLLRRCRRDDGTG 3849
                 +P++VAY+RGY +++ +  L++PS + + + DP+T E L+Y QLL+R   D  TG
Sbjct: 5022 VHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETG 5081

Query: 3850 QLLLPLS 3856
             L L LS
Sbjct: 5082 LLFLSLS 5088



 Score =  177 bits (449), Expect = 2e-43
 Identities = 132/409 (32%), Positives = 206/409 (50%), Gaps = 15/409 (3%)

Query: 3001 ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAV 3060
            A  IAGV++E +GQ  S+Y A+++ LLP+ +  ALLEAQA TG ++D A    L V +A+
Sbjct: 40   ARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQALLEAQAATGGLVDLARGQLLPVSKAL 99

Query: 3061 RAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3120
            + GLVG E  EKLL+AE+A TGY DPY G+ ++LFQA+ K ++ R  G   L+ QL+TGG
Sbjct: 100  QQGLVGLELKEKLLAAERATTGYPDPYGGEKLALFQAIGKEVVDRALGQSWLEVQLATGG 159

Query: 3121 IVDPSKSHRVPLDVACARGCLDEETSRALS--APRADAKAYSDPSTGEPATYGELQQRCR 3178
            +VDP++   V  + AC +G LD ET   LS   P      + +P+T E  TY +L +RC 
Sbjct: 160  LVDPAQGVLVAPEPACHQGLLDRETWHKLSELEPGTGDLRFLNPNTLERLTYHQLLERCV 219

Query: 3179 PDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSE 3238
                +GL+LLPL             +EL      ++  V+   G  +GR   V     +E
Sbjct: 220  RAPGSGLALLPLKITFRSMGGAVSAAELLEVGILDEQAVQ---GLREGRLAAVDVSARAE 276

Query: 3239 YFTAEQRQELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLAS 3298
                      +R++  G  +V  V+ +     +       E L   G   P+  ++    
Sbjct: 277  ----------VRRYLEGTGSVAGVVLLPEGHKKSFFQAATEHLLPMGTALPLLEAQAATH 326

Query: 3299 GVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLL 3358
             ++     ++L   +     L        LL     + G +   +  ++ +++AM++GL+
Sbjct: 327  TLVDPITGQRLWVDEAVRAGLVSPELHEQLLVAEQAVTGHHDPFSGSQIPLFQAMKKGLV 386

Query: 3359 RATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSA 3407
                A  LL+AQ ATG LV P R  RL +  A++ G +  +   QL  A
Sbjct: 387  DRPLALRLLDAQLATGGLVCPARRLRLPLEAALRCGCLDEDTQRQLSQA 435



 Score =  107 bits (267), Expect = 3e-22
 Identities = 73/212 (34%), Positives = 111/212 (52%), Gaps = 5/212 (2%)

Query: 4243 TQLASWSDPTEETGPVAGIL-----DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG 4297
            T++ S     E T  +AG+L          EK+SI +AM + ++   T   LLEAQA TG
Sbjct: 4347 TEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATG 4406

Query: 4298 GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWL 4357
             +IDP    R  V +AV  G+V   + +++  A++A  G+ DP T  ++S  QA++K  +
Sbjct: 4407 FVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLI 4466

Query: 4358 YYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPK 4417
              E G R LE Q  TGG+I+P    RVP+D A +RG  D    + L D    +K    P 
Sbjct: 4467 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 4526

Query: 4418 TKLKISYKDALDRSMVEEGTGLRLLEAAAQST 4449
            T   ++Y   L R + +  TGL +L+ A + +
Sbjct: 4527 THENLTYVQLLRRCVPDPDTGLYMLQLAGRGS 4558



 Score =  107 bits (266), Expect = 4e-22
 Identities = 73/210 (34%), Positives = 109/210 (51%), Gaps = 5/210 (2%)

Query: 4243 TQLASWSDPTEETGPVAGIL-----DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTG 4297
            T++ S     E T  +AG+L          EK+SI +AM + ++   T   LLEAQA TG
Sbjct: 4881 TEMDSVKRYLEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATG 4940

Query: 4298 GIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWL 4357
             +IDP    R  V +AV  G+V   + +++  A++A  G+ DP T  ++S  QA++K  +
Sbjct: 4941 FVIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLI 5000

Query: 4358 YYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPK 4417
              E G R LE Q  TGG+I+P    RVP+D A +RG  D    + L D    +K    P 
Sbjct: 5001 VREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPN 5060

Query: 4418 TKLKISYKDALDRSMVEEGTGLRLLEAAAQ 4447
            T   ++Y   L R+ ++  TGL  L  + Q
Sbjct: 5061 THENLTYLQLLQRATLDPETGLLFLSLSLQ 5090



 Score =  105 bits (261), Expect = 1e-21
 Identities = 69/217 (31%), Positives = 114/217 (52%), Gaps = 3/217 (1%)

Query: 4229 GSSSSYPIS-PAVSRTQLASWSDPTEETGPVAGILDTETLEKVSITEAMHRNLVDNITGQ 4287
            G++S+   S P      L + + P  +   +AG+    + +  S+  AM + L+    GQ
Sbjct: 13   GTNSTEQASVPRAMAATLGAGTPPRPQARSIAGVYVEASGQAQSVYAAMEQGLLPAGLGQ 72

Query: 4288 RLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMS 4347
             LLEAQA TGG++D + G+  PV+ A+ +GLV   + +++  A++A  G+ DP    K++
Sbjct: 73   ALLEAQAATGGLVDLARGQLLPVSKALQQGLVGLELKEKLLAAERATTGYPDPYGGEKLA 132

Query: 4348 AAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRGTVDARTAQKLRDV- 4406
              QA+ K  +    GQ +LEVQ  TGGL++P     V  + A  +G +D  T  KL ++ 
Sbjct: 133  LFQAIGKEVVDRALGQSWLEVQLATGGLVDPAQGVLVAPEPACHQGLLDRETWHKLSELE 192

Query: 4407 -GAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4442
             G        P T  +++Y   L+R +   G+GL LL
Sbjct: 193  PGTGDLRFLNPNTLERLTYHQLLERCVRAPGSGLALL 229



 Score = 70.5 bits (171), Expect = 4e-11
 Identities = 61/227 (26%), Positives = 102/227 (44%), Gaps = 17/227 (7%)

Query: 3918 VDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPE 3977
            ++ T+ERLS  +   +G+ R  +A EL  +       +  +     T++E   M  V   
Sbjct: 4832 IEETEERLS--KVSFRGLRRQVSASELHTSGILGPETLRDLAQGTKTLQEVTEMDSVKRY 4889

Query: 3978 FKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESH 4037
             +     A   V     P   + +S++QAM KG++     + LLEAQ ATG +IDP  + 
Sbjct: 4890 LEGTSCIAGVLVPAKDQPGRQEKMSIYQAMWKGVLRPGTALVLLEAQAATGFVIDPVRNL 4949

Query: 4038 RLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCLL 4097
            RL VE A   G+   E+ E L        G+ DP T + ++  Q M++ +   + G+ LL
Sbjct: 4950 RLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLL 5009

Query: 4098 PLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQ 4144
                   E + ++          ++DP     + V  AYR+G  D +
Sbjct: 5010 -------EAQIATGG--------VIDPVHSHRVPVDVAYRRGYFDEE 5041



 Score = 60.8 bits (146), Expect = 3e-08
 Identities = 32/119 (26%), Positives = 61/119 (51%)

Query: 2670 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2729
            L    ++ G     T +++S++ A+Q+ L+     + LLEAQ A+G ++DPV + R+ V+
Sbjct: 4971 LSAERAVTGYTDPYTGQQISLFQAMQKDLIVREHGIRLLEAQIATGGVIDPVHSHRVPVD 5030

Query: 2730 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQI 2788
             A + G    E++  L        G+ DP T + ++  Q +Q+  +  E G+  L   +
Sbjct: 5031 VAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLQRATLDPETGLLFLSLSL 5089



 Score = 47.0 bits (110), Expect = 4e-04
 Identities = 37/167 (22%), Positives = 73/167 (43%)

Query: 4261 ILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVD 4320
            ++D     ++S+ EA+   +V     ++LL A+    G  DP TG++  +  A+ K L+ 
Sbjct: 4408 VIDPVRNLRLSVEEAVAAGVVGGEIQEKLLSAERAVTGYTDPYTGQQISLFQAMQKDLIV 4467

Query: 4321 KIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDT 4380
            +    R+  AQ A  G  DP    ++    A ++G+   E  +   +    T G  +P+T
Sbjct: 4468 REHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNT 4527

Query: 4381 PGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDA 4427
               +   + L+R   D  T   +  +      +     +L+ + +DA
Sbjct: 4528 HENLTYVQLLRRCVPDPDTGLYMLQLAGRGSAVHQLSEELRCALRDA 4574


>gi|58530842 desmoplakin isoform II [Homo sapiens]
          Length = 2272

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 3618 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3677
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 1369 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 1425

Query: 3678 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3737
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 1426 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 1485

Query: 3738 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3797
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 1486 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 1545

Query: 3798 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3856
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 1546 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 1605

Query: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 1606 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 1664

Query: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 1665 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 1724

Query: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 1725 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 1784

Query: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 1785 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 1844

Query: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 1845 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 1904

Query: 4157 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4216
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 1905 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 1964

Query: 4217 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4262
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 1965 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024

Query: 4263 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4322
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084

Query: 4323 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4382
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144

Query: 4383 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4442
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204

Query: 4443 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4494
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 2205 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2264

Query: 4495 FSSSS 4499
            FSSSS
Sbjct: 2265 FSSSS 2269



 Score =  597 bits (1538), Expect = e-169
 Identities = 411/1467 (28%), Positives = 760/1467 (51%), Gaps = 101/1467 (6%)

Query: 386  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 445
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135

Query: 446  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 502
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187

Query: 503  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 562
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246

Query: 563  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 622
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298

Query: 623  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 682
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358

Query: 683  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 742
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418

Query: 743  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 802
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478

Query: 803  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 862
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538

Query: 863  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 922
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598

Query: 923  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 962
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658

Query: 963  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1012
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715

Query: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773

Query: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833

Query: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1192
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893

Query: 1193 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1252
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953

Query: 1253 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013

Query: 1312 IKFISETLRRMEE-EERLAEQQRAEERERLA-EVEAALEKQRQLAEAHAQAKAQAEREAK 1369
             +F+SE L+ +E+ + +  + +  EE  RLA +  +    + +  + + Q K QAE    
Sbjct: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQ-KYQAECSQF 1072

Query: 1370 ELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIE 1429
            + +    EE+ R  +A +D +  K+++ +   Q+++ +E +I     + E  +R R  +E
Sbjct: 1073 KAKLASLEELKR--QAELDGKSAKQNLDKCYGQIKELNE-KITRLTYEIEDEKRRRKSVE 1129

Query: 1430 EEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489
            +     +   +  ++ R   + E + L  +  E+E   ++ + E ERLR  +Q+E  RKR
Sbjct: 1130 DRFDQQKNDYDQLQKAR---QCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKR 1186

Query: 1490 QAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQ 1549
            + E ELA       E+  +  + +Q  E L ++ +  E+     +  R ++++  L  A+
Sbjct: 1187 EYENELAKASNRIQESKNQCTQVVQERESLLVKIKVLEQ-----DKARLQRLEDELNRAK 1241

Query: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAE-AERAREEAERE 1608
             + EAE + K+    EK  Q++  L +     ++ +EEA R+ + + E +ER +     E
Sbjct: 1242 STLEAETRVKQRLECEK-QQIQNDLNQWKTQYSR-KEEAIRKIESEREKSEREKNSLRSE 1299

Query: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668
            +ER Q +         +  E + +++ +Q E E+ + + E +  R+         Q E  
Sbjct: 1300 IERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTE-C 1358

Query: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETE-----QGEQQRQLLEEELARLQREAAA 1723
            E  ++  + + +G  ++  A +    +L  +T      +G++  + +  E+    R A +
Sbjct: 1359 EWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGS 1418

Query: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG--------RFR 1775
                    + + + V A+ + L+            + E +   LEA+A         R  
Sbjct: 1419 IAGASASPKEKYSLVEAKRKKLI------------SPESTVMLLEAQAATGGIIDPHRNE 1466

Query: 1776 ELAEEAARLRALAEEAKRQRQLAEEDA 1802
            +L  ++A  R L +   RQ+  A E A
Sbjct: 1467 KLTVDSAIARDLIDFDDRQQIYAAEKA 1493



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 2914 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2969
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 1259 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1318

Query: 2970 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3026
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 1319 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1376

Query: 3027 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3086
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 1377 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 1426

Query: 3087 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3146
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 1427 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 1484

Query: 3147 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3190
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 1485 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 1544

Query: 3191 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3247
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 1545 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 1589

Query: 3248 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3307
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 1590 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 1635

Query: 3308 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3367
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 1636 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 1693

Query: 3368 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3427
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 1694 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 1753

Query: 3428 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3487
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 1754 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 1813

Query: 3488 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3547
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 1814 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 1871

Query: 3548 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3599
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 1872 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 1922

Query: 3600 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3630
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 1923 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 1982

Query: 3631 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3683
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 1983 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2033

Query: 3684 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3743
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 2034 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2093

Query: 3744 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3803
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 2094 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2153

Query: 3804 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3862
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 2154 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2210

Query: 3863 FRGLRKQITM 3872
             +GL     M
Sbjct: 2211 SKGLPSPYNM 2220



 Score =  417 bits (1072), Expect = e-115
 Identities = 363/1343 (27%), Positives = 649/1343 (48%), Gaps = 181/1343 (13%)

Query: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
            A + A    L+ R  D   RFL E  + ++ +  +  ++ V  +E    R    E+  + 
Sbjct: 997  ADVHARYIELLTRSGDY-YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKN 1055

Query: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF 2342
            + L + + K + +  Q   +L A  E L++Q EL  + A++  +      ++L E+    
Sbjct: 1056 KFLDQNLQKYQAECSQFKAKL-ASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRL 1114

Query: 2343 QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402
               +E E++R+  +    ++ K    ++ +A+          + + E +G +   +E A 
Sbjct: 1115 TYEIEDEKRRRKSVEDRFDQQKNDYDQLQKAR----------QCEKENLGWQKLESEKAI 1164

Query: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2462
            +EK   ++ L +  Q+   +  R RE   EL +   ++Q+       K++  Q VQ    
Sbjct: 1165 KEKEYEIERLRVLLQE---EGTRKREYENELAKASNRIQES------KNQCTQVVQ---- 1211

Query: 2463 LQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQE 2522
                         E++SLL + + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E
Sbjct: 1212 -------------ERESLLVKIKVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECE 1257

Query: 2523 RQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQ 2582
            +Q++   + + + +    EE +R+ + E ++ E+++      L  E +RL+ +++ +EE+
Sbjct: 1258 KQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS----LRSEIERLQAEIKRIEER 1313

Query: 2583 HRAALAHSEEVTASQVAATKT-----LPNGRDALDGPAAEAEPEHS---------FDGLR 2628
             R  L  S   T SQ+   ++     +   R    G   E + E           FDGLR
Sbjct: 1314 CRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLR 1373

Query: 2629 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKL 2688
            +KV+A +L E  ++    L +L +G  +V+E+A   +++ +L+G  SIAG    +  EK 
Sbjct: 1374 KKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVA--SEIQPFLRGAGSIAGASA-SPKEKY 1430

Query: 2689 SVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSA 2748
            S+  A +++L+SP + ++LLEAQAA+G ++DP RN +LTV+ A+   ++  +   ++ +A
Sbjct: 1431 SLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAA 1490

Query: 2749 ERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAY 2808
            E+A+TG+ DP++G+ +S+ +A++K LI RE G+RLLEAQIA+GGV+DPV+S  +P DVA 
Sbjct: 1491 EKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVAL 1550

Query: 2809 RRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAK 2868
             RG  D ++ R L DP D  K F DP T + ++Y+QL ERC  +P TGL LL +      
Sbjct: 1551 ARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSV------ 1604

Query: 2869 GGELVYTDSEARDVFEKATVSAPFGKFQG--KTVTIWEIINSEYFTAEQRRDLLRQFRTG 2926
                           +K ++S     FQG  + VT+ E+++S       R   + +  +G
Sbjct: 1605 ---------------QKRSMS-----FQGIRQPVTVTELVDSGIL----RPSTVNELESG 1640

Query: 2927 RITVEKIIKII---------ITVVEEQEQKGRL-CFEGLR-SLV---PAAELLESR---- 2968
            +I+ +++ + I         I  +  +  K +L  +E ++  LV    A ELLE++    
Sbjct: 1641 QISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATG 1700

Query: 2969 -VIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLL 3027
             ++D     +L   E   R +  ++   + L     + G    E G  +S++ A+ K+L+
Sbjct: 1701 FIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELI 1760

Query: 3028 PSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPY 3087
                 + LLEAQ  TG IIDP  S RL VD A + G    E  E L        G+ DP 
Sbjct: 1761 EKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPN 1820

Query: 3088 TGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSR 3147
            T ++++  Q  ++ +   E GL LL  +     +    K+      V      +D ET++
Sbjct: 1821 TEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV----IVDPETNK 1876

Query: 3148 ALSAPRADAKAYSDPSTGEPATYGEL-QQRCRPDQLTGLSLLPLSEKAARARQEELYSEL 3206
             +S   A  K   D       T+ EL +Q C  +++T    +  S+ + R         L
Sbjct: 1877 EMSVQEAYKKGLIDYE-----TFKELCEQECEWEEIT----ITGSDGSTRV-------VL 1920

Query: 3207 QARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQELLRQFRTGKVTVEKVIKIL 3266
              R+T  +  ++  +   KG       L+  ++F          Q+R+G +++ +   ++
Sbjct: 1921 VDRKTGSQYDIQDAID--KG-------LVDRKFFD---------QYRSGSLSLTQFADMI 1962

Query: 3267 ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVR 3326
                               L+  V  S  + SGV S   F   +    +V  +S + SVR
Sbjct: 1963 ------------------SLKNGVGTSSSMGSGV-SDDVFSSSR--HESVSKISTISSVR 2001

Query: 3327 TL----------LQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFL 3376
             L          L+ S  +A I+  +  EK+SI E + RG++ + T   LLEAQA TG +
Sbjct: 2002 NLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGI 2061

Query: 3377 VDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLR 3436
            + P   Q+L + +AV  GV+  ++  +L  A+KA  G+        +S  +A+++  +  
Sbjct: 2062 IHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPY 2121

Query: 3437 QHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTH 3496
            + G R LE Q  TGG++DP    R+  + A ++G+      + L D S   K    P T 
Sbjct: 2122 EAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTK 2181

Query: 3497 ENLTYRQLLERCVEDPETGLRLL 3519
              ++Y+  + R + +  TGLRLL
Sbjct: 2182 LKISYKDAINRSMVEDITGLRLL 2204



 Score =  372 bits (956), Expect = e-102
 Identities = 232/608 (38%), Positives = 341/608 (56%), Gaps = 39/608 (6%)

Query: 2623 SFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLLLK 2682
            SF G+R+ V+   L ++GIL    +  L  G  + DE+  R  ++ +LQG S IAG+  +
Sbjct: 1610 SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGER--IKDFLQGSSCIAGIYNE 1667

Query: 2683 ATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELH 2742
             T +KL +Y A++  L+ PGTAL LLEAQAA+GF++DPV N RL V EA K G+VG E  
Sbjct: 1668 TTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFK 1727

Query: 2743 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2802
             KLLSAERAVTGY DP TG  ISLFQAM K LI + HGIRLLEAQIATGG+IDP  SHR+
Sbjct: 1728 EKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRL 1787

Query: 2803 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2862
            PVD+AY+RGYF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLLPL
Sbjct: 1788 PVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPL 1847

Query: 2863 TDK----------AAKGGELVYTDSEA------RDVFEKATVSAPFGKFQGKTVTIWEII 2906
             +K            +   +V  D E       ++ ++K  +     K   +    WE I
Sbjct: 1848 KEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEI 1907

Query: 2907 NSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLRSL 2958
                     R  L+ +    +  ++  I   ++     +Q + G L          L++ 
Sbjct: 1908 TITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNG 1967

Query: 2959 VPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAGVW 3008
            V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA ++
Sbjct: 1968 VGTSSSMGSGVSD-DVFSSSRH--ESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2024

Query: 3009 LEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3068
              E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++  +
Sbjct: 2025 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2084

Query: 3069 FHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSH 3128
               +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP    
Sbjct: 2085 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2144

Query: 3129 RVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLL 3188
            R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL LL
Sbjct: 2145 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2204

Query: 3189 PLSEKAAR 3196
              +  +++
Sbjct: 2205 EAASVSSK 2212



 Score =  259 bits (663), Expect = 3e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 1363 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 1422

Query: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 1423 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 1481

Query: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 1482 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 1541

Query: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 1542 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 1601

Query: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 1602 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 1644

Query: 4157 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4212
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 1645 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 1691

Query: 4213 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4269
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 1692 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 1748

Query: 4270 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4329
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 1749 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 1808

Query: 4330 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4374
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 1809 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 1868

Query: 4375 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4421
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 1869 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 1928

Query: 4422 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4481
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 1929 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 1988

Query: 4482 GS---FDATGSGFSMTFSSSSYSSS 4503
             S        S  ++T  SSS+S +
Sbjct: 1989 ESVSKISTISSVRNLTIRSSSFSDT 2013



 Score =  111 bits (278), Expect = 1e-23
 Identities = 100/383 (26%), Positives = 182/383 (47%), Gaps = 34/383 (8%)

Query: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1750
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077

Query: 1751 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1807
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137

Query: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+   
Sbjct: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASN 1197

Query: 1868 DIEE---RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924
             I+E   +  Q+ +  +S L + K L +D  R +R                      LE 
Sbjct: 1198 RIQESKNQCTQVVQERESLLVKIKVLEQDKARLQR----------------------LED 1235

Query: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKA 1984
            EL R +S  E   R K++ E E  + +    + + +    EE ++K  +  E++ R++ +
Sbjct: 1236 ELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNS 1295

Query: 1985 ALEEVERLKAKV----EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
               E+ERL+A++    E  RR  E + +E+  QL+  +   Q+ +    +    + ++ +
Sbjct: 1296 LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQ 1355

Query: 2041 QELQQTLQQEQSVLDQLRGEAEA 2063
             E + T+   + V D LR +  A
Sbjct: 1356 TECEWTVDTSKLVFDGLRKKVTA 1378



 Score = 99.8 bits (247), Expect = 6e-20
 Identities = 62/210 (29%), Positives = 109/210 (51%)

Query: 2670 LQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVN 2729
            L+  S IA +      EK+S+   ++R ++   T   LLEAQA +G ++ P   ++L++ 
Sbjct: 2014 LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQ 2073

Query: 2730 EAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIA 2789
            +AV +GV+  ++  +L  A++A  G++     +++S  +A+++  +  E G R LE Q  
Sbjct: 2074 DAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYL 2133

Query: 2790 TGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERC 2849
            TGG++DP    R+  + A R+G+ D    + L D S   K    P T   ++Y   + R 
Sbjct: 2134 TGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS 2193

Query: 2850 VEDPETGLCLLPLTDKAAKGGELVYTDSEA 2879
            + +  TGL LL     ++KG    Y  S A
Sbjct: 2194 MVEDITGLRLLEAASVSSKGLPSPYNMSSA 2223


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score =  964 bits (2491), Expect = 0.0
 Identities = 497/905 (54%), Positives = 679/905 (75%), Gaps = 27/905 (2%)

Query: 3618 YDYVRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPG 3677
            +D +R+++TA  L+E ++I   T + L +G +S+ E   A     +L G GS+AG     
Sbjct: 1968 FDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEV--ASEIQPFLRGAGSIAGASA-S 2024

Query: 3678 SRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHD 3737
             ++  S+ +A +K L+S E   +LLEAQAATG ++DP + E+LTVD A+ + L+  +   
Sbjct: 2025 PKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQ 2084

Query: 3738 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLP 3797
            ++ +AE+A+TG+ DP++ +T+S+ +A+KK LI  E  +RLL+AQ+A+GG+VDP     LP
Sbjct: 2085 QIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLP 2144

Query: 3798 LEVAYQRGYLNKDTHDQLSEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLS 3856
             +VA  RG +++D +  L++P +  +++VDP T +++SY QL  RCR +  TG LLL + 
Sbjct: 2145 KDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQ 2204

Query: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916
              R ++F+G+R+ +T+ ELV S ++  +T  +L  G  S +EV + ++ FL+G+SCIAG+
Sbjct: 2205 K-RSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGI 2263

Query: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976
            + + TK++L +Y+AMK G++RPGTA ELLEAQAATG+++DP+  L+L VEEA + G+VG 
Sbjct: 2264 YNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGI 2323

Query: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036
            EFK+KLLSAERAVTGY DP +G +ISLFQAM K LI K HGIRLLEAQIATGGIIDP+ES
Sbjct: 2324 EFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKES 2383

Query: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096
            HRLPV++AYKRG F+EE++EIL+DPSDDTKGFFDPNTEENLTYLQL ERCI D +TGLCL
Sbjct: 2384 HRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCL 2443

Query: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156
            LPLKEKK++ +TS K+++RKRRVVIVDPET KEMSV EAY+KGLID++T+ EL EQECEW
Sbjct: 2444 LPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEW 2503

Query: 4157 EEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4216
            EEITI+ SDG  + +++DR++G QYDI DAI K L+DR   DQYR+G+LS+T+FADM+S 
Sbjct: 2504 EEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISL 2563

Query: 4217 NAGGFRSRSSSVG------SSSSYPISPAVS--------RTQLASWSDPTEETGPVAGIL 4262
              G   S S   G      SSS +     +S          + +S+SD  EE+ P+A I 
Sbjct: 2564 KNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIF 2623

Query: 4263 DTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKI 4322
            DTE LEK+SITE + R +VD+ITGQRLLEAQACTGGII P+TG++  + DAV++G++D+ 
Sbjct: 2624 DTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQD 2683

Query: 4323 MVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPG 4382
            M  R+  AQKAF GFE  + K KMSAA+A+K+ WL YEAGQRFLE QYLTGGL++P+  G
Sbjct: 2684 MATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHG 2743

Query: 4383 RVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLL 4442
            R+  +EA+++G +D R AQ+L+D  +Y+K LTCPKTKLKISYKDA++RSMVE+ TGLRLL
Sbjct: 2744 RISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLL 2803

Query: 4443 EAAAQSTKGYYSPYSVSG-----SGSTAGSRTGSRTGSRAGSRRGSFDATGS---GFSMT 4494
            EAA+ S+KG  SPY++S      SGS +GSR+GSR+GSR+GSRRGSFDATG+    +S +
Sbjct: 2804 EAASVSSKGLPSPYNMSSAPGSRSGSRSGSRSGSRSGSRSGSRRGSFDATGNSSYSYSYS 2863

Query: 4495 FSSSS 4499
            FSSSS
Sbjct: 2864 FSSSS 2868



 Score =  862 bits (2228), Expect = 0.0
 Identities = 745/2950 (25%), Positives = 1363/2950 (46%), Gaps = 355/2950 (12%)

Query: 386  CEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQG 445
            C + L +A+ ++Q +++    G    R+ E++    +A+  + +L + ++ ++    P  
Sbjct: 78   CSDCLMRAELIVQPELKY-GDGIQLTRSRELDECFAQANDQMEILDSLIREMRQMGQPC- 135

Query: 446  EQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTL---QSVQRRPELEDSTLRY 502
            +   +R+ +L E++ A        L   ++ P  + A        + Q     ++ T   
Sbjct: 136  DAYQKRLLQLQEQMRA--------LYKAISVPRVRRASSKGGGGYTCQSGSGWDEFTKHV 187

Query: 503  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 562
              + L W+ + +  +D   WGVDL SVE  + SHRG+H SI ++R ++++ ++D  + S 
Sbjct: 188  TSECLGWMRQQRAEMDMVAWGVDLASVEQHINSHRGIHNSIGDYRWQLDKIKADLREKS- 246

Query: 563  ATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDW 622
                     + +L+ +Y  LL +S  R+  L  L + + A ++E+MW+N+ EEEE+ +DW
Sbjct: 247  --------AIYQLEEEYENLLKASFERMDHLRQLQNIIQATSREIMWINDCEEEELLYDW 298

Query: 623  SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQW 682
            SD+NTN+  K+E++S  M +LE+KEK++ +L+   D+L+   HPA   +E++   LQTQW
Sbjct: 299  SDKNTNIAQKQEAFSIRMSQLEVKEKELNKLKQESDQLVLNQHPASDKIEAYMDTLQTQW 358

Query: 683  SWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLL 742
            SW+LQ+  CI+ HLKENAAYFQFF + +  E  L+ LQ+++R+KY CD++  +  L + +
Sbjct: 359  SWILQITKCIDVHLKENAAYFQFFEEAQSTEAYLKGLQDSIRKKYPCDKNMPLQHLLEQI 418

Query: 743  QDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHK 802
            ++ + E+E++ EYK  +  L  ++K +VQLKPR+P +     + L A+CDYKQ +  VHK
Sbjct: 419  KELEKEREKILEYKRQVQNLVNKSKKIVQLKPRNPDYRSNKPIILRALCDYKQDQKIVHK 478

Query: 803  GDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWH 862
            GDEC L    + S W V    G +  VPSV  ++PPPN  A +   ++E  ++A++ LW+
Sbjct: 479  GDECILKDNNERSKWYVTGPGGVDMLVPSVGLIIPPPNPLAVDLSCKIEQYYEAILALWN 538

Query: 863  QLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAG 922
            QL+++MKSL++W     D++ IR+ ++A  +T++ E+  + +  LELHYQ F+R+SQ + 
Sbjct: 539  QLYINMKSLVSWHYCMIDIEKIRAMTIAKLKTMRQEDYMKTIADLELHYQEFIRNSQGSE 598

Query: 923  GFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEES----------RCQR---------- 962
             FG +D+   + ++     HYQ L+  L    Q ++           CQ           
Sbjct: 599  MFGDDDKRKIQSQFTDAQKHYQTLVIQLPGYPQHQTVTTTEITHHGTCQDVNHNKVIETN 658

Query: 963  ---------CISELKDIRLQLEACETRTVHRLRLPL-DKEPARECAQRIAEQQKAQAEVE 1012
                      + EL+ IR Q+E CE R   +  LPL D+  +     +I E +  Q +  
Sbjct: 659  RENDKQETWMLMELQKIRRQIEHCEGRMTLK-NLPLADQGSSHHITVKINELKSVQND-- 715

Query: 1013 GLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072
               + +A +  + + +LA    S     L++E+     KLE +  ++  YL  L T+  +
Sbjct: 716  --SQAIAEVLNQLKDMLANFRGSEKYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRAL 773

Query: 1073 IRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELR 1132
            ++     E++L+ +E +L E + V   L ++EA +  LKK++     ++     ++ EL+
Sbjct: 774  LQAILQTEDMLKVYEARLTEEETVCLDLDKVEAYRCGLKKIKNDLNLKKSLLATMKTELQ 833

Query: 1133 GAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRE 1192
             AQ++  +  Q++   D+++ ++ E+V QL +RWQ +  Q D R  +LE+  +QLR YR+
Sbjct: 834  KAQQIHSQTSQQYPLYDLDLGKFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRD 893

Query: 1193 SADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQ 1252
            +      WL DA+RRQ+ +++M   DS  V   L +++ L  EI    +K EE Q+ A+ 
Sbjct: 894  NYQAFCKWLYDAKRRQDSLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAEL 953

Query: 1253 YINAIKDYELQLVTYKAQLEPVAS-PAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQY 1311
              N+IKDYELQL +Y + LE + + P K+  +QS S  ++QE  D+   Y EL T +  Y
Sbjct: 954  CANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGVILQEAADVHARYIELLTRSGDY 1013

Query: 1312 IKFISETLRR-------------MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAH 1357
             +F+SE L+              +EEE RLA    +E   +   ++  L+K Q + ++  
Sbjct: 1014 YRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANSENCNKNKFLDQNLQKYQAECSQFK 1073

Query: 1358 A------QAKAQAEREAKELQQ----------RMQEEVVRREEAAVDAQQQKRSIQEELQ 1401
            A      + K QAE + K  +Q           + E++ R      D +++++S+++   
Sbjct: 1074 AKLASLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFD 1133

Query: 1402 QLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAE 1461
            Q  Q ++ +   KARQ E         +E +   +L+ E   +++   E E++ LR   +
Sbjct: 1134 Q--QKNDYDQLQKARQCE---------KENLGWQKLESEKAIKEK---EYEIERLRVLLQ 1179

Query: 1462 EAEAQKRQAQEEAERLRRQVQDES---QRKRQAEVELASRVKAEAEAAREKQRALQALEE 1518
            E   +KR+ + E  ++R    +E    + K + E+ +      E    +E        + 
Sbjct: 1180 EEGTRKREYENELAKVRNHYNEEMSNLRNKYETEINITKTTIKEISMQKEDDS-----KN 1234

Query: 1519 LRLQAEEAERRLRQAEVERAR---QVQVALETAQRSAEAELQSKR--ASFAEKTAQLERS 1573
            LR Q +   R  R  + E  R    +  A E  +R+ E  LQ K   +   +K   LE  
Sbjct: 1235 LRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIE 1294

Query: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE-EVAQQ 1632
            L++    + Q  E+  R  Q   EA +  ++  +E+ER + +  E  + R + E E+++ 
Sbjct: 1295 LKQ---VMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKV 1351

Query: 1633 KSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1692
            ++    E    K + E E         Q   Q+   E++    R   +   ++  +  +E
Sbjct: 1352 RNNYDEEIISLKNQFETEINITKTTIHQLTMQK---EEDTSGYRAQIDNLTRENRSLSEE 1408

Query: 1693 LIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752
            + RL+    Q  +  + +EE++ + +   +  +Q++Q+LE EL +V         ++ R 
Sbjct: 1409 IKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQV---------TQMRT 1459

Query: 1753 EEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAER 1811
            EE     S + KQ L+  A   ++  +E  RL+ L ++    R+  E++ AR QR + + 
Sbjct: 1460 EE-----SVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYD- 1513

Query: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEE 1871
                    + +A    TE    LK +E E  RLR   E  + +R   ++   + +  ++E
Sbjct: 1514 --------LQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE 1565

Query: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR--- 1928
               Q +K  + EL R K    +   +R+++EEE+  ++ S ++ A     L  +L +   
Sbjct: 1566 LQLQKQKV-EEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASI 1624

Query: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQ------- 1981
            ++  +ED LR +        R++Q   EE RR     E +++ L  E+E+ +Q       
Sbjct: 1625 VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEH 1684

Query: 1982 -RKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE 2040
             +KA  ++   L     E  RL+   E  +   L L +E    RL+ ++     +    +
Sbjct: 1685 FQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADSD 1744

Query: 2041 Q-----ELQQTLQ-------QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQ 2088
            +     EL+  LQ       + Q +++ L+ E E  R+  E+ ++  ++A     +S+ Q
Sbjct: 1745 KNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQ 1804

Query: 2089 VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKH 2148
              +  + ++S   + +   Q +A  ++L    E E  R     +A  R KQ  + E ++ 
Sbjct: 1805 CTQVVQERESLLVKIKVLEQDKARLQRL----EDELNRAKSTLEAETRVKQRLECEKQQI 1860

Query: 2149 KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATE-AARQRSQVEEE 2207
            +    Q   Q ++ E+ +  +  + E+++ +KN L  E++RL+AE      R R ++E+ 
Sbjct: 1861 QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLED- 1919

Query: 2208 LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE---KMKQVAEEAARLSVA 2264
              S R    +L   ++R + E   L  R    + R  Q E E      ++  +  R  V 
Sbjct: 1920 --STRETQSQLETERSRYQREIDKLRQRPY-GSHRETQTECEWTVDTSKLVFDGLRKKVT 1976

Query: 2265 AQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRL 2324
            A       QL E  L  +  L +K+LK K                               
Sbjct: 1977 AM------QLYECQLIDKTTL-DKLLKGK------------------------------- 1998

Query: 2325 QEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2384
                 +  +++A E Q F R   +     +  ++ + + K  + E  R +  + E     
Sbjct: 1999 -----KSVEEVASEIQPFLRGAGS-----IAGASASPKEKYSLVEAKRKKLISPESTVML 2048

Query: 2385 RKQAEEIGEKL--HRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ 2442
             +     G  +  HR E  T +       ++   +Q  + AE+      +    K     
Sbjct: 2049 LEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVS 2108

Query: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
            EA    L   E         L E Q      +   +S+     F+ ++ A    L   ++
Sbjct: 2109 EAIKKNLIDRE-----TGMRLLEAQIASGGVVDPVNSV-----FLPKDVALARGLIDRDL 2158

Query: 2503 AKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE 2562
             ++  L + +  Q+  ++   ++ V+ ++   R + E   G       L  L  Q+R   
Sbjct: 2159 YRS--LNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTG-------LLLLSVQKRSM- 2208

Query: 2563 ELLAEENQRLREQLQLLEEQHRAALAHS--EEVTASQVAATKTLPNGRDALDGPAAEAEP 2620
                   Q +R+ + + E      L  S   E+ + Q++  +     +D L G +  A  
Sbjct: 2209 -----SFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIA-- 2261

Query: 2621 EHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGRSSIAGLL 2680
                 G+  + + Q+L   GI  A ++  +  G  T  EL         L+ +++   ++
Sbjct: 2262 -----GIYNETTKQKL---GIYEAMKIGLVRPG--TALEL---------LEAQAATGFIV 2302

Query: 2681 LKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2740
               +N +L V  A +R L+       LL A+ A     DP     +++ +A+ + ++   
Sbjct: 2303 DPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKG 2362

Query: 2741 LHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSH 2800
               +LL A+ A  G  DP    ++ +  A ++G                           
Sbjct: 2363 HGIRLLEAQIATGGIIDPKESHRLPVDIAYKRG--------------------------- 2395

Query: 2801 RVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLL 2860
                       YF+EE++ +L+DPSDDTKGFFDPNT ENLTYLQL ERC++D ETGLCLL
Sbjct: 2396 -----------YFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLL 2444

Query: 2861 PLTDK----------AAKGGELVYTDSE------ARDVFEKATVSAPFGKFQGKTVTIWE 2904
            PL +K            +   +V  D E       ++ ++K  +     K   +    WE
Sbjct: 2445 PLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWE 2504

Query: 2905 IINSEYFTAEQRRDLLRQFRTGRITVEKIIK--IIITVVEEQEQKGRLCFE------GLR 2956
             I         R  L+ +    +  ++  I   ++     +Q + G L          L+
Sbjct: 2505 EITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLK 2564

Query: 2957 SLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRR----------ALRGANVIAG 3006
            + V  +  + S V D +++   +    SV  ++ + +VR            L  ++ IA 
Sbjct: 2565 NGVGTSSSMGSGVSD-DVFSSSR--HESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA 2621

Query: 3007 VWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVG 3066
            ++  E  +K+SI   +++ ++ S     LLEAQA TG II P T  +L++ +AV  G++ 
Sbjct: 2622 IFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVID 2681

Query: 3067 PEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSK 3126
             +   +L  A+KA  G+      + +S  +A+K+  +P E G R L+ Q  TGG+VDP  
Sbjct: 2682 QDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEV 2741

Query: 3127 SHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLS 3186
              R+  + A  +G +D   ++ L    + AK  + P T    +Y +   R   + +TGL 
Sbjct: 2742 HGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLR 2801

Query: 3187 LLPLSEKAAR 3196
            LL  +  +++
Sbjct: 2802 LLEAASVSSK 2811



 Score =  544 bits (1401), Expect = e-154
 Identities = 502/1978 (25%), Positives = 899/1978 (45%), Gaps = 304/1978 (15%)

Query: 1692 ELIRLRAETEQGEQQRQLLEEELARLQREAAAAT-QKRQELEAELAKVRAEMEVLLASKA 1750
            E+++   + +    + ++LEEEL RL R+A +    K + L+  L K +AE     A  A
Sbjct: 1019 EMLKSLEDLKLKNTKIEVLEEEL-RLARDANSENCNKNKFLDQNLQKYQAECSQFKAKLA 1077

Query: 1751 RAEEESRSTS---EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRA 1807
              EE  R      + +KQ L+   G+ +EL E+  RL    E+ KR+R+  E+   +Q+ 
Sbjct: 1078 SLEELKRQAELDGKSAKQNLDKCYGQIKELNEKITRLTYEIEDEKRRRKSVEDRFDQQKN 1137

Query: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
            + +++   +          K E+E A+KEKE E ERLR L ++E  ++R  E + A+ + 
Sbjct: 1138 DYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRN 1197

Query: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
               E ++ LR   ++E+   K  +++   Q+   E++   L+   ++ +    +L+ E+ 
Sbjct: 1198 HYNEEMSNLRNKYETEINITKTTIKEISMQK---EDDSKNLRNQLDRLSRENRDLKDEIV 1254

Query: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
            R+  +       + +AE  A +Q+   +E  ++++  E  +++ +    E   + K +LE
Sbjct: 1255 RLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSEDNARHKQSLE 1314

Query: 1988 EVER-LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA--------------- 2031
            E  + ++ K +E  RL+   ++E+ R+ +   E ++ R   +E+                
Sbjct: 1315 EAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITK 1374

Query: 2032 ---HAFAVQQKE-----------------------QELQQTLQQEQSVLDQLRGEAEAAR 2065
               H   +Q++E                       + L+ TL Q    L ++  + +  +
Sbjct: 1375 TTIHQLTMQKEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQK 1434

Query: 2066 RAAEEAEEARVQAEREAAQ-SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
                E  + + Q E E  Q ++ + EE+ R KQS ++ A+         E+L++  ++E 
Sbjct: 1435 ATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKET 1494

Query: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
              R   E    R  Q    +++K    A +T+ +    EQELT LR+  E    ++ + D
Sbjct: 1495 NDRKCLEDENARL-QRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKD 1553

Query: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244
            +++ R +    E   Q+ +VEEEL  ++    E S  + ++E E   +        +R L
Sbjct: 1554 QDITRFQNSLKELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGM--------RRSL 1605

Query: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
            +E+A K+  + ++  + S+       +++ +E+DL QQR + +  L+EK +  +E  RL 
Sbjct: 1606 KEQAIKITNLTQQLEQASI-------VKKRSEDDLRQQRDVLDGHLREKQRTQEELRRLS 1658

Query: 2305 AEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364
            +E E L++Q  L QEQ         +  +Q     + FQ+ +E + +   E   E ERL+
Sbjct: 1659 SEVEALRRQ--LLQEQ---------ESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQ 1707

Query: 2365 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2424
                 +++     EE+ +  R + +++  +  R+E  + +  T+++ L  Q Q S++   
Sbjct: 1708 SLTENLTKEHLMLEEELRNLRLEYDDL--RRGRSEADSDKNATILE-LRSQLQISNNRTL 1764

Query: 2425 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2484
             L+  I +L+RE+E L+QE +  Q ++ E     QE   Q TQ +Q     E++SLL + 
Sbjct: 1765 ELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQ-----ERESLLVKI 1819

Query: 2485 RFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGV 2544
            + +EQ+KA+L++L +DE+ +A+   E + R +Q++E E+Q++   + + + +    EE +
Sbjct: 1820 KVLEQDKARLQRL-EDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAI 1878

Query: 2545 RRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTL 2604
            R+ + E ++ E+++      L  E +RL+ +++ +EE+ R  L  S   T SQ+      
Sbjct: 1879 RKIESEREKSEREKNS----LRSEIERLQAEIKRIEERCRRKLEDSTRETQSQL------ 1928

Query: 2605 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARRE 2664
                          E E S    R +    +L++    S  E Q   +   TVD      
Sbjct: 1929 --------------ETERS----RYQREIDKLRQRPYGSHRETQ--TECEWTVD------ 1962

Query: 2665 DVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNR 2724
                                  KL V+  L++++    TA+ L E Q      LD +   
Sbjct: 1963 --------------------TSKL-VFDGLRKKV----TAMQLYECQLIDKTTLDKLLKG 1997

Query: 2725 RLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLL 2784
            + +V E      V  E+   L  A         P   ++ SL +A +K LI  E  + LL
Sbjct: 1998 KKSVEE------VASEIQPFLRGAGSIAGASASPK--EKYSLVEAKRKKLISPESTVMLL 2049

Query: 2785 EAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQ 2844
            EAQ ATGG+IDP  + ++ VD A  R   D +  + +        GF DP + + ++  +
Sbjct: 2050 EAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSE 2109

Query: 2845 LLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVTIWE 2904
             +++ + D ETG+ LL    + A GG +   +S    VF    V+   G           
Sbjct: 2110 AIKKNLIDRETGMRLLEA--QIASGGVVDPVNS----VFLPKDVALARGL---------- 2153

Query: 2905 IINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQE---------------QKGR 2949
            I    Y +    RD  + F      V+ + K  ++ V+ +E               QK  
Sbjct: 2154 IDRDLYRSLNDPRDSQKNF------VDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRS 2207

Query: 2950 LCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWL 3009
            + F+G+R  V   EL++S ++      +L+ G+ S  +V E   ++  L+G++ IAG++ 
Sbjct: 2208 MSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGE--RIKDFLQGSSCIAGIYN 2265

Query: 3010 EEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEF 3069
            E   QKL IY A+K  L+    A+ LLEAQA TG I+DP ++ RL V+EA + GLVG EF
Sbjct: 2266 ETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEF 2325

Query: 3070 HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHR 3129
             EKLLSAE+AVTGY DP TG  +SLFQA+ K LI +  G+RLL+AQ++TGGI+DP +SHR
Sbjct: 2326 KEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHR 2385

Query: 3130 VPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP 3189
            +P+D+A  RG  +EE S  LS P  D K + DP+T E  TY +L++RC  D+ TGL LLP
Sbjct: 2386 LPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLP 2445

Query: 3190 LSEKAARARQE---------------ELYSELQARETFEKTPV----------------E 3218
            L EK  + +                 E   E+  +E ++K  +                E
Sbjct: 2446 LKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEE 2505

Query: 3219 VPVGGFKG--RTVTVWELISSEYFTAEQ------RQELLRQFRTGKVTVEKVIKIL---- 3266
            + + G  G  R V V     S+Y   +        ++   Q+R+G +++ +   ++    
Sbjct: 2506 ITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKN 2565

Query: 3267 ------------------------ITIVEEVETLRQERLSFSGLRAPVPASELLASGVLS 3302
                                    ++ +  + ++R   +  S     +  S  +A+ +  
Sbjct: 2566 GVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAA-IFD 2624

Query: 3303 RAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATT 3362
                E++   +   + + +  + + LL+   C  GI    T +K+S+ +A+ +G++    
Sbjct: 2625 TENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDM 2684

Query: 3363 AALLLEAQAA--------------------------------------TGFLVDPVRNQR 3384
            A  L  AQ A                                      TG LVDP  + R
Sbjct: 2685 ATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGR 2744

Query: 3385 LYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLE 3444
            +   EA++ G +     ++L            P +   IS   A+ + +V    G+RLLE
Sbjct: 2745 ISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLE 2804

Query: 3445 -AQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTY 3501
             A +++ G+  P +    P   +  R              S   +G FD   + + +Y
Sbjct: 2805 AASVSSKGLPSPYNMSSAPGSRSGSRS--GSRSGSRSGSRSGSRRGSFDATGNSSYSY 2860



 Score =  419 bits (1078), Expect = e-116
 Identities = 326/1030 (31%), Positives = 519/1030 (50%), Gaps = 139/1030 (13%)

Query: 2914 EQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRV---- 2969
            +Q ++ L Q++T     E+ I+ I +  E+ E++       +  L    + +E R     
Sbjct: 1858 QQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKL 1917

Query: 2970 --IDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLE-EAGQKLSIYNALKKDL 3026
                RE   QL+  ERS R   E+D +R+   G++       E        +++ L+K +
Sbjct: 1918 EDSTRETQSQLET-ERS-RYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKV 1975

Query: 3027 LPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDP 3086
                 A+ L E Q      +D     + +V+E      V  E    L  A         P
Sbjct: 1976 T----AMQLYECQLIDKTTLDKLLKGKKSVEE------VASEIQPFLRGAGSIAGASASP 2025

Query: 3087 YTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETS 3146
               +  SL +A +K LI  E  + LL+AQ +TGGI+DP ++ ++ +D A AR  +D +  
Sbjct: 2026 K--EKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDR 2083

Query: 3147 RALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLP----------------L 3190
            + + A       + DP +G+  +  E  ++   D+ TG+ LL                 L
Sbjct: 2084 QQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFL 2143

Query: 3191 SEKAARAR---QEELYSELQARETFEKTPVEVPVGGFKGRTVTVWELISSEYFTAEQRQE 3247
             +  A AR     +LY  L      +K  V+ PV   K   V + E              
Sbjct: 2144 PKDVALARGLIDRDLYRSLNDPRDSQKNFVD-PVTKKKVSYVQLKE-------------- 2188

Query: 3248 LLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFE 3307
                    +  +E    +L+  V++        +SF G+R PV  +EL+ SG+L  +   
Sbjct: 2189 --------RCRIEPHTGLLLLSVQK------RSMSFQGIRQPVTVTELVDSGILRPSTVN 2234

Query: 3308 QLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLL 3367
            +L+ G+ +  ++ E   ++  LQGS C+AGIY E TK+K+ IYEAM+ GL+R  TA  LL
Sbjct: 2235 ELESGQISYDEVGE--RIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELL 2292

Query: 3368 EAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQ 3427
            EAQAATGF+VDPV N RL V EA K G+VG E  E+LLSAE+AVTGY DP +G+ ISLFQ
Sbjct: 2293 EAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQ 2352

Query: 3428 AMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDT 3487
            AM K L+ + HGIRLLEAQIATGGIIDP  SHR+PVD+AY+RGYF+EE++ +L+DPSDDT
Sbjct: 2353 AMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDT 2412

Query: 3488 KGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAFEE 3547
            KGFFDPNT ENLTY QL ERC++D ETGL LLPLK  EK + V+T+Q  T  + R    +
Sbjct: 2413 KGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLK--EKKKQVQTSQKNTLRKRRVVIVD 2470

Query: 3548 TQIDIPGGGSHGGSTMSLWEVMQSDLIPEEQRAQLM---ADFQAGRVT----KERMIII- 3599
             + +           MS+ E  +  LI  E   +L     +++   +T      R++++ 
Sbjct: 2471 PETN---------KEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVD 2521

Query: 3600 --------IIEIIEKTEIIR------QQGLASYDYVRRRLT---------------AEDL 3630
                    I + I+K  + R      + G  S       ++               ++D+
Sbjct: 2522 RKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDV 2581

Query: 3631 FE-------ARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLS 3683
            F        ++I ++ +   L   + S  + LE  S          +A ++   + + +S
Sbjct: 2582 FSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESS---------PIAAIFDTENLEKIS 2632

Query: 3684 IYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAE 3743
            I + +++G++ +   + LLEAQA TG ++ P  G++L++ +AV +G++  ++  RL  A+
Sbjct: 2633 ITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQ 2692

Query: 3744 RAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQ 3803
            +A  G+     ++ +S  +A+K++ +P E   R L+ Q  TGG+VDP +   +  E A +
Sbjct: 2693 KAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIR 2752

Query: 3804 RGYLNKDTHDQLSEPSEVRSYVD-PSTDERLSYTQLLRRCRRDDGTGQLLLPLSDARKLT 3862
            +G+++     +L + S     +  P T  ++SY   + R   +D TG   L L +A  ++
Sbjct: 2753 KGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITG---LRLLEAASVS 2809

Query: 3863 FRGLRKQITM 3872
             +GL     M
Sbjct: 2810 SKGLPSPYNM 2819



 Score =  259 bits (663), Expect = 3e-68
 Identities = 203/685 (29%), Positives = 334/685 (48%), Gaps = 72/685 (10%)

Query: 3857 DARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGV 3916
            D  KL F GLRK++T  +L   Q++D+ T  +L +G  S+EEV   +Q FL G   IAG 
Sbjct: 1962 DTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGA 2021

Query: 3917 FVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGP 3976
               + KE+ S+ +A +K +I P +   LLEAQAATG +IDP +  KLTV+ A+   ++  
Sbjct: 2022 SA-SPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDF 2080

Query: 3977 EFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEES 4036
            + + ++ +AE+A+TG+ DP+SGK +S+ +A+KK LI ++ G+RLLEAQIA+GG++DP  S
Sbjct: 2081 DDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNS 2140

Query: 4037 HRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLCL 4096
              LP +VA  RGL D ++   L DP D  K F DP T++ ++Y+QL ERC  +P TGL L
Sbjct: 2141 VFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLL 2200

Query: 4097 LPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEW 4156
            L +     ++++ S   +R            + ++V E    G++   T  EL   +  +
Sbjct: 2201 LSV-----QKRSMSFQGIR------------QPVTVTELVDSGILRPSTVNELESGQISY 2243

Query: 4157 EEITISSSDGVVKSM----IIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFAD 4212
            +E+     D +  S     I +  + ++  I +A+   L+        R GT       +
Sbjct: 2244 DEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV--------RPGTA-----LE 2290

Query: 4213 MLSGNAG-GFRSRSSSVGSSSSYPISPAVSR--TQLASWSDPTEETGPVAGILDTETLEK 4269
            +L   A  GF        S+   P+  A  R    +            V G  D ET   
Sbjct: 2291 LLEAQAATGF---IVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNI 2347

Query: 4270 VSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINL 4329
            +S+ +AM++ L++   G RLLEAQ  TGGIIDP    R PV  A  +G  ++ + + ++ 
Sbjct: 2348 ISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSD 2407

Query: 4330 AQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEV-----QYLTGG---------- 4374
                  GF DP T+  ++  Q  ++     E G   L +     Q  T            
Sbjct: 2408 PSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVV 2467

Query: 4375 LIEPDTPGRVPLDEALQRGTVDARTAQKLRDV-------------GAYSKYLTCPKTKLK 4421
            +++P+T   + + EA ++G +D  T ++L +              G+    L   KT  +
Sbjct: 2468 IVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQ 2527

Query: 4422 ISYKDALDRSMVEEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRR 4481
               +DA+D+ +V+     +    +   T+        +G G+++   +G      + SR 
Sbjct: 2528 YDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRH 2587

Query: 4482 GS---FDATGSGFSMTFSSSSYSSS 4503
             S        S  ++T  SSS+S +
Sbjct: 2588 ESVSKISTISSVRNLTIRSSSFSDT 2612


>gi|4502443 dystonin isoform 1e precursor [Homo sapiens]
          Length = 2649

 Score =  921 bits (2380), Expect = 0.0
 Identities = 596/2064 (28%), Positives = 1094/2064 (53%), Gaps = 117/2064 (5%)

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE        
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE-------- 1106

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQ-QRMQEEVVRREEAAVDAQQQK 1393
                        +++ ++ +E  A +     ++A  L+  ++  ++   E    + ++QK
Sbjct: 1107 ------------IKRCKETSEHGAYSDLLQRQKATVLENSKLTGKISELERMVAELKKQK 1154

Query: 1394 RSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL 1453
              ++EEL ++R+++E E++ + R  E     ++R E E +  R +LE   R++  AE EL
Sbjct: 1155 SRVEEELPKVREAAENELRKQQRNVEDISLQKIRAESEAKQYRRELETIVREKEAAEREL 1214

Query: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRAL 1513
            + +R    EAEA++   +E     R Q+++ +  +R  E  L  +  +  +  ++K + +
Sbjct: 1215 ERVRQLTIEAEAKRAAVEENLLNFRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLM 1274

Query: 1514 QALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573
            + L   R   EE  + ++Q E + A Q QVA +  +   + EL+++R     K  +++ +
Sbjct: 1275 EELRRKRDNEEELLKLIKQMEKDLAFQKQVAEKQLKEKQKIELEARR-----KITEIQYT 1329

Query: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633
             +E  + V  + +    RA    + E  +++AE EL++   + +E      +AE+  ++ 
Sbjct: 1330 CRENALPVCPITQATSCRAVTGLQQEHDKQKAE-ELKQ---QVDELTAANRKAEQDMREL 1385

Query: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693
            +      + +K  +E +AR      ++        + ELE++ Q  +G +QQ     ++L
Sbjct: 1386 TYELNALQLEKTSSEEKARLLKDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQL 1445

Query: 1694 IRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAE 1753
             +   + E+  Q+   L++     Q E  +   ++ +L+ E+ ++               
Sbjct: 1446 NQTTGKAEEAMQEASDLKKIKRNYQLELESLNHEKGKLQREVDRI--------------- 1490

Query: 1754 EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE--DAARQRAEAER 1811
              + + +EK+ Q L ++   FR+  +E  RL+    ++   ++  E+  +   Q  +AE+
Sbjct: 1491 TRAHAVAEKNIQHLNSQIHSFRD-EKELERLQICQRKSDHLKEQFEKSHEQLLQNIKAEK 1549

Query: 1812 VLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLE---EQAAQHKAD 1868
               +K+  + E      E    LK+K    E L R   +     +R++   E     K  
Sbjct: 1550 ENNDKIQRLNEELEKSNECAEMLKQKV---EELTRQNNETKLMMQRIQAESENIVLEKQT 1606

Query: 1869 IEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR 1928
            I++R   L+  +D   + Q     + L ++ + E++        E+  A    L  E  +
Sbjct: 1607 IQQRCEALKIQADG-FKDQLRSTNEHLHKQTKTEQDFQRKIKCLEEDLAKSQNLVSEF-K 1664

Query: 1929 IRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEE 1988
             + + ++ +    + E+        A++EE+RR E + ++Q             +A ++E
Sbjct: 1665 QKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQLQ-------------QAQVQE 1711

Query: 1989 VERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQ 2048
            +     KV++   L+   EQ + R++ L QE + K  Q+ E+      ++K ++L ++  
Sbjct: 1712 LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEE-----FRKKMEKLMESKV 1766

Query: 2049 QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQ 2108
              ++ +  +R +  + ++    A+E     E    +  RQ      L+Q  E+  Q +  
Sbjct: 1767 ITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQ------LQQYREQMQQGQHM 1820

Query: 2109 AQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELT- 2167
                 +K +K  ++  A++ + E   L+QK     +  +H+    Q   QK    ++ T 
Sbjct: 1821 EANHYQKCQKLEDELIAQKREVEN--LKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTF 1878

Query: 2168 --TLRLQLEETDHQKNLLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQMEELSKLK 2222
                 + ++E  H   L       L            Q  Q  EE +  RV +E++ K +
Sbjct: 1879 KPDFEMTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRV-VEQIPK-E 1936

Query: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
             + +     L   +K+ +Q+   E        ++ +  L +   E   + +L+E +  + 
Sbjct: 1937 VQFQPPGAPL---EKEKSQQCYSE------YFSQTSTELQITFDETNPITRLSEIEKIRD 1987

Query: 2283 RALAEKMLKEKMQ---AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2339
            +AL       + Q      E  ++    E+ + ++     +   L+++K  +        
Sbjct: 1988 QALNNSRPPVRYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWML 2047

Query: 2340 QGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQA---EEIGEKLH 2396
            +G + +   ++   L+   E E  +    + + +    E   Q  R      + +  KL 
Sbjct: 2048 EGCRASGGLKKGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLL 2107

Query: 2397 RTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEA--------KLLQ 2448
                  Q ++ L    E+Q+  +    +    A   LE  KEK+   +        K++ 
Sbjct: 2108 DMRTIEQLRLGLKTVEEVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVA 2167

Query: 2449 LKSEEMQTVQQ---EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA 2505
            L   E Q       + +  +T +++ + L        R R +E EKA +   +  +    
Sbjct: 2168 LAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYSYSSKTLSV 2227

Query: 2506 QQLREEQQRQQQQMEQERQRLVAS 2529
             Q  E +   +Q+ +   +  +AS
Sbjct: 2228 FQAMENRMLDRQKGKHILEAQIAS 2251



 Score =  414 bits (1064), Expect = e-114
 Identities = 249/679 (36%), Positives = 385/679 (56%), Gaps = 65/679 (9%)

Query: 3797 PLEVAYQRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT-------- 3848
            PLE+A  + Y   D H +++   + ++ V PS +E      +L  CR   G         
Sbjct: 2014 PLEIAKNKQY---DMHTEVTTLKQEKNPV-PSAEE-----WMLEGCRASGGLKKGDFLKK 2064

Query: 3849 -----------GQLLLPLSDARKLTFRGLRKQITMEELVRSQVMDEATALQLREGLTSIE 3897
                       G     + D  +  F+GLR  +T  +LV ++++D  T  QLR GL ++E
Sbjct: 2065 GLEPETFQNFDGDHACSVRDD-EFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVE 2123

Query: 3898 EVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDP 3957
            EV K L KFL   + IAG+++++TKE++S   A ++ II    A   LEAQAATG++IDP
Sbjct: 2124 EVQKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDP 2183

Query: 3958 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHG 4017
            I G   +VE+AV  G+V PEF+ +LL AE+A  GY   YS K +S+FQAM+  ++ +  G
Sbjct: 2184 ISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKG 2241

Query: 4018 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL 4077
              +LEAQIA+GG+IDP    R+P E+A ++GL +  + + L +PS +T+ F +PN ++ L
Sbjct: 2242 KHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQAL 2301

Query: 4078 TYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYR 4137
             Y +L+  C+ D ++   L P      ER  S+ +  +  R+ +VD +TG E++VYEA++
Sbjct: 2302 YYSELLRMCVFDVESQCFLFPF----GERNISNLNVKKTHRISVVDTKTGSELTVYEAFQ 2357

Query: 4138 KGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSAL 4197
            + LI+   YLELS Q+ +W+E     S G    M+ D ++G  ++I++AI +  ID++ +
Sbjct: 2358 RNLIEKSIYLELSGQQYQWKEAMFFESYGHSSHMLTDTKTGLHFNINEAIEQGTIDKALV 2417

Query: 4198 DQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGP 4257
             +Y+ G +++TE AD L                     +S  V +  L S         P
Sbjct: 2418 KKYQEGLITLTELADSL---------------------LSRLVPKKDLHS---------P 2447

Query: 4258 VAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKG 4317
            VAG   T + E++S+ +A  RNLVD IT  R LEAQ  TGGIIDP TG+++ V +A+++G
Sbjct: 2448 VAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRG 2507

Query: 4318 LVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIE 4377
            LVD+    ++   +    G   P T   MS  +A+    +  E G R LE QYLTGGLIE
Sbjct: 2508 LVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIE 2567

Query: 4378 PDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGT 4437
            P    R+ ++EALQ G +D   A KL+D  +Y + + CP+TK K++YK+AL+++  +  T
Sbjct: 2568 PQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHT 2627

Query: 4438 GLRLLEAAAQSTKGYYSPY 4456
            GL+LLE +     G  S Y
Sbjct: 2628 GLKLLEVSEPLMTGISSLY 2646



 Score =  411 bits (1056), Expect = e-114
 Identities = 537/2416 (22%), Positives = 1013/2416 (41%), Gaps = 334/2416 (13%)

Query: 1016 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1075
            K V R   E E   +L E   +   + + L+LT    E++  L + Y + L T     R 
Sbjct: 316  KNVHRAIEEFES--SLKEAKISEIQMTAPLKLTYA--EKLHRLESQYAKLLNTSRNQERH 371

Query: 1076 TQGAEE-VLRAHEEQL----KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDE 1130
                   V RA  E +    KE + V     E     A  K   A+   +    D   + 
Sbjct: 372  LDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRE---LDQKEEN 428

Query: 1131 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1190
            ++  QE+ E+L   +    + +E +R   A +  +W  +L      ++ +++      ++
Sbjct: 429  IKSVQEIAEQLLLENHPARLTIEAYR---AAMQTQWSWILQLCQCVEQHIKENTAYFEFF 485

Query: 1191 ---RESADPLGAWLQDARRRQEQIQAMP--------LADSQAVREQLRQEQALLEEIERH 1239
               +E+ D L   L+DA +R+               + +S   +E+L Q ++ +  +   
Sbjct: 486  NDAKEATDYLRN-LKDAIQRKYSCDRSSSIHKLEDLVQESMEEKEELLQYKSTIANLMGK 544

Query: 1240 GEKV-------EECQRFAKQYINAIKDY-ELQLVTYKAQLEPVASPAKKPKVQ----SGS 1287
             + +        +C       I AI DY ++++  YK     +A+ + + K +    +G+
Sbjct: 545  AKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECVLANNSHRAKWKVISPTGN 604

Query: 1288 ESVI-----------QEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE 1336
            E+++           +E VDL     +      QY     + +  +  E  +  +     
Sbjct: 605  EAMVPSVCFTVPPPNKEAVDLANRIEQ------QY-----QNVLTLWHESHINMKSVVSW 653

Query: 1337 RERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSI 1396
               + E++    +   +A        + ++    LQ R ++ +   +E+ V +      +
Sbjct: 654  HYLINEIDRI--RASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSDITQL 711

Query: 1397 QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQAL 1456
            ++E+   +Q  +  +++  R+ +      L I E +R +RL+LE  E +       ++ +
Sbjct: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISE-VRNIRLRLENCEDRL------IRQI 764

Query: 1457 RARAEEAEAQKRQAQ-EEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
            R   E  +  +   +  E E+L++++  E  +     +           AA      L++
Sbjct: 765  RTPLERDDLHESVFRITEQEKLKKEL--ERLKDDLGTITNKCEEFFSQAAASSSVPTLRS 822

Query: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
               + LQ       +    +++ + V + L+  Q +AEA ++       E+ A +     
Sbjct: 823  ELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQ-AAEALVKLYETKLCEEEAVIADKNN 881

Query: 1576 EEHV--AVAQLREEAERRAQ---------QQAEA----------------ERAREEAERE 1608
             E++   + Q R E + + Q         Q+A+A                +  +E+A++ 
Sbjct: 882  IENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL 941

Query: 1609 LERWQ---------LKANEALRLRLQ--------AEEVAQQKSLAQAEAEKQKEEAEREA 1651
            +ERWQ         L+  E +   L+         ++  QQ    Q + ++ + E  +  
Sbjct: 942  VERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTL 1001

Query: 1652 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711
              +   ++  V + E+ + ++++ ++ AE  +      E + +  RA  +   QQ+  ++
Sbjct: 1002 ATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDS--QQKSPVK 1059

Query: 1712 EELARLQREAAAATQKRQELEAELAKVRAEMEVLLA----SKARAEEES----RSTSEKS 1763
                R+Q  A    Q+  +L      +   M   +     S  R EEE     + TSE  
Sbjct: 1060 RR--RMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEIKRCKETSEHG 1117

Query: 1764 K-----QRLEAEA-------GRFRELAEEAARLRA----LAEEAKRQRQLAEEDAARQRA 1807
                  QR +A         G+  EL    A L+     + EE  + R+ AE +  +Q+ 
Sbjct: 1118 AYSDLLQRQKATVLENSKLTGKISELERMVAELKKQKSRVEEELPKVREAAENELRKQQR 1177

Query: 1808 EAERVLAEKLAAIGEATRLKTEAEIALKEKEA---ENERLRRLAEDEAFQRRRLEEQAAQ 1864
              E +  +K+ A  EA + + E E  ++EKEA   E ER+R+L  +   +R  +EE    
Sbjct: 1178 NVEDISLQKIRAESEAKQYRRELETIVREKEAAERELERVRQLTIEAEAKRAAVEENLLN 1237

Query: 1865 HKADIEERLAQLRKASD---------SELERQKGLVEDTLRQRRQVEEEILALKASFEKA 1915
             +  +EE     R   D         ++LE+QK  + + LR++R  EEE+L L    EK 
Sbjct: 1238 FRNQLEENTFTRRTLEDHLKRKDLSLNDLEQQKNKLMEELRRKRDNEEELLKLIKQMEKD 1297

Query: 1916 AAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAE 1975
             A + ++          AE  L+ K++ ELEA R+        R        + ++ +  
Sbjct: 1298 LAFQKQV----------AEKQLKEKQKIELEARRKITEIQYTCRENALPVCPITQATSCR 1347

Query: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQ-KRLQAEEKAHAF 2034
                 Q++   ++ E LK +V+E      +AEQ+  R+L     A Q ++  +EEKA   
Sbjct: 1348 AVTGLQQEHDKQKAEELKQQVDELTAANRKAEQDM-RELTYELNALQLEKTSSEEKARLL 1406

Query: 2035 AVQQKEQ---------ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
              +  E          EL++  Q E+    QLR       +   +AEEA  +A       
Sbjct: 1407 KDKLDETNNTLRCLKLELERKDQAEKGYSQQLRELGRQLNQTTGKAEEAMQEASDLKKIK 1466

Query: 2086 RRQVEEAERL---KQSAEEQAQARAQAQAAAEK-----------LRKEAEQEAARRAQAE 2131
            R    E E L   K   + +     +A A AEK            R E E E  +  Q +
Sbjct: 1467 RNYQLELESLNHEKGKLQREVDRITRAHAVAEKNIQHLNSQIHSFRDEKELERLQICQRK 1526

Query: 2132 QAALRQK---------QAADAEMEKHKKFAEQTLRQKAQVEQELTT-LRLQLEETDHQKN 2181
               L+++         Q   AE E + K   Q L ++ +   E    L+ ++EE   Q N
Sbjct: 1527 SDHLKEQFEKSHEQLLQNIKAEKENNDKI--QRLNEELEKSNECAEMLKQKVEELTRQNN 1584

Query: 2182 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQM-----------EELSKLKARIEAENR 2230
                 +QR++AE+     ++  +++   ++++Q            E L K     +   R
Sbjct: 1585 ETKLMMQRIQAESENIVLEKQTIQQRCEALKIQADGFKDQLRSTNEHLHKQTKTEQDFQR 1644

Query: 2231 ALILRDKD--NTQRFLQEEAEKMKQ-------VAEEAARLSVAAQEAARLRQLAEEDLAQ 2281
             +   ++D   +Q  + E  +K  Q         +E   L+     +   ++  E+ +  
Sbjct: 1645 KIKCLEEDLAKSQNLVSEFKQKCDQQNIIIQNTKKEVRNLNAELNASKEEKRRGEQKVQL 1704

Query: 2282 QRALAEKMLKEKMQAVQEATRLKA-EAELLQQQKELAQEQARRLQEDKEQMAQQLAE--- 2337
            Q+A  ++ L  +++ VQ+   LK  E ++  ++  L QE++ + ++  E+  +++ +   
Sbjct: 1705 QQAQVQE-LNNRLKKVQDELHLKTIEEQMTHRKMVLFQEESGKFKQSAEEFRKKMEKLME 1763

Query: 2338 -------ETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
                   +  G +    + +Q        A+  +  + E+ R   +  E  Q+ +     
Sbjct: 1764 SKVITENDISGIRLDFVSLQQENSRAQENAKLCETNIKELERQLQQYREQMQQGQHMEAN 1823

Query: 2391 IGEKLHRTE---LATQEKV-TLVQTLEIQRQQSDHDAERLREAIAELEREKE-------- 2438
              +K  + E   +A + +V  L Q ++ Q ++ +H    L+  I +    K+        
Sbjct: 1824 HYQKCQKLEDELIAQKREVENLKQKMDQQIKEHEHQLVLLQCEIQKKSTAKDCTFKPDFE 1883

Query: 2439 ----KLQQEAKLLQLKSEEMQTVQQEQLL---QETQALQQSFLSEKDSLLQRERFIEQEK 2491
                + Q   +L    +  +    +  LL   QE Q L++ +       + +E   +   
Sbjct: 1884 MTVKECQHSGELSSRNTGHLHPTPRSPLLRWTQEPQPLEEKWQHRVVEQIPKEVQFQPPG 1943

Query: 2492 AKLEQLFQDEVAKAQQLREE---QQRQQQQMEQERQRLVASMEEARRRQHEAEEGVR--- 2545
            A LE+       K+QQ   E   Q   + Q+  +    +  + E  + + +A    R   
Sbjct: 1944 APLEK------EKSQQCYSEYFSQTSTELQITFDETNPITRLSEIEKIRDQALNNSRPPV 1997

Query: 2546 RKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLP 2605
            R Q+   ++E  +      +A+  Q          +Q +  +  +EE       A+  L 
Sbjct: 1998 RYQDNACEMELVKVLTPLEIAKNKQYDMHTEVTTLKQEKNPVPSAEEWMLEGCRASGGLK 2057

Query: 2606 NGRDALDGPAAEA-------------EPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ 2652
             G     G   E              + E  F GLR  V+A++L EA +L    +++L  
Sbjct: 2058 KGDFLKKGLEPETFQNFDGDHACSVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRL 2117

Query: 2653 GHTTVDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQA 2712
            G  TV+E+  ++ +  +L   +SIAGL L++T EK+S  +A +R ++    AL  LEAQA
Sbjct: 2118 GLKTVEEV--QKTLNKFLTKATSIAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQA 2175

Query: 2713 ASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQK 2772
            A+GF++DP+  +  +V +AV +GVV PE   +LL AE+A  GY   Y+ + +S+FQAM+ 
Sbjct: 2176 ATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMEN 2233

Query: 2773 GLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFF 2832
             ++ R+ G  +LEAQIA+GGVIDPV   RVP ++A ++G  +  + + L +PS +T+ F 
Sbjct: 2234 RMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFP 2293

Query: 2833 DPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPF 2892
            +PN  + L Y +LL  CV D E+   L P        GE   ++   +     + V    
Sbjct: 2294 NPNNKQALYYSELLRMCVFDVESQCFLFPF-------GERNISNLNVKKTHRISVVDTK- 2345

Query: 2893 GKFQGKTVTIWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCF 2952
                G  +T++E                      R  +EK I + ++  ++ + K  + F
Sbjct: 2346 ---TGSELTVYEAFQ-------------------RNLIEKSIYLELS-GQQYQWKEAMFF 2382

Query: 2953 E--------------GLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRAL 2998
            E              GL   +   E +E   ID+ L ++ Q G  ++ ++A+    R   
Sbjct: 2383 ESYGHSSHMLTDTKTGLHFNI--NEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVP 2440

Query: 2999 RG--ANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTV 3056
            +    + +AG WL  +G+++S+  A +++L+    A+  LEAQ  TG IIDP T  +  V
Sbjct: 2441 KKDLHSPVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRV 2500

Query: 3057 DEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3116
             EA+  GLV   F ++L   E  +TG   P T + +S+ +A+   +I +E G+R L+ Q 
Sbjct: 2501 AEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQY 2560

Query: 3117 STGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQR 3176
             TGG+++P    R+ ++ A   G +D   +  L   ++  +    P T    TY E  ++
Sbjct: 2561 LTGGLIEPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEK 2620

Query: 3177 CRPDQLTGLSLLPLSE 3192
               D  TGL LL +SE
Sbjct: 2621 ADFDFHTGLKLLEVSE 2636



 Score =  262 bits (669), Expect = 7e-69
 Identities = 188/591 (31%), Positives = 297/591 (50%), Gaps = 43/591 (7%)

Query: 3275 TLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGC 3334
            ++R +   F GLR  V A +L+ + +L     EQL+ G  TV+++ +  ++   L  +  
Sbjct: 2081 SVRDDEFKFQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATS 2138

Query: 3335 LAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAG 3394
            +AG+YLE TKEK+S   A  R ++    A   LEAQAATGF++DP+  Q   V +AV  G
Sbjct: 2139 IAGLYLESTKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKG 2198

Query: 3395 VVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIID 3454
            VV PE   +LL AEKA  GY   YS  T+S+FQAM+  ++ RQ G  +LEAQIA+GG+ID
Sbjct: 2199 VVDPEFRIRLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVID 2256

Query: 3455 PVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPET 3514
            PV   RVP ++A Q+G  +  + + L +PS +T+ F +PN  + L Y +LL  CV D E+
Sbjct: 2257 PVRGIRVPPEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVES 2316

Query: 3515 GLRLLPL--KGAEKAEVVETTQVYTEEETRRAFEETQIDIPGGGSHGGSTMSLWEVMQSD 3572
               L P   +      V +T ++   +                 +  GS ++++E  Q +
Sbjct: 2317 QCFLFPFGERNISNLNVKKTHRISVVD-----------------TKTGSELTVYEAFQRN 2359

Query: 3573 LIPEEQRAQLMA-DFQAGRVTKERMIIIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLF 3631
            LI +    +L    +Q     KE M               + GL             +  
Sbjct: 2360 LIEKSIYLELSGQQYQ----WKEAMFFESYGHSSHMLTDTKTGL--------HFNINEAI 2407

Query: 3632 EARIISLETYNLLREGTRSLREALEAESAWCYLYGT----GSVAGVYLPGSRQTLSIYQA 3687
            E   I        +EG  +L E   A+S    L         VAG +L  S + +S+ +A
Sbjct: 2408 EQGTIDKALVKKYQEGLITLTEL--ADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKA 2465

Query: 3688 LKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLLSAERAVT 3747
             ++ L+    A   LEAQ +TG ++DP+ G++  V EA+ +GLV      +L   E  +T
Sbjct: 2466 SRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVIT 2525

Query: 3748 GYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYL 3807
            G   P T + +S+ +A+   +I  E  +R L+ Q  TGG+++P++   L +E A Q G +
Sbjct: 2526 GIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGII 2585

Query: 3808 NKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSD 3857
            +     +L  + S VR+ + P T  +L+Y + L +   D  TG  LL +S+
Sbjct: 2586 DVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSE 2636



 Score =  260 bits (664), Expect = 2e-68
 Identities = 169/550 (30%), Positives = 284/550 (51%), Gaps = 74/550 (13%)

Query: 3621 VRRRLTAEDLFEARIISLETYNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQ 3680
            +R  +TA  L EA+++ + T   LR G +++ E  +  +   +L    S+AG+YL  +++
Sbjct: 2092 LRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQKTLNK--FLTKATSIAGLYLESTKE 2149

Query: 3681 TLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRLL 3740
             +S   A ++ ++   VA   LEAQAATGF++DP+ G+  +V++AV KG+V PE   RLL
Sbjct: 2150 KISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRIRLL 2209

Query: 3741 SAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEV 3800
             AE+A  GY   Y+ +T+S+FQAM+  ++  ++   +L+AQ+A+GG++DP  G  +P E+
Sbjct: 2210 EAEKAAVGY--SYSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVPPEI 2267

Query: 3801 AYQRGYLNKDTHDQLSEP-SEVRSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPLSDAR 3859
            A Q+G LN      L EP S  R + +P+  + L Y++LLR C  D  +   L P  + R
Sbjct: 2268 ALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFGE-R 2326

Query: 3860 KLTFRGLRK-------------QITMEELVRSQVMDEATALQL----------------- 3889
             ++   ++K             ++T+ E  +  +++++  L+L                 
Sbjct: 2327 NISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFESYG 2386

Query: 3890 ----------------------------------REGLTSIEEVTKNLQKFL----EGTS 3911
                                              +EGL ++ E+  +L   L    +  S
Sbjct: 2387 HSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHS 2446

Query: 3912 CIAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRM 3971
             +AG ++ A+ ER+SV +A ++ ++   TA   LEAQ +TG +IDP+ G K  V EA+  
Sbjct: 2447 PVAGYWLTASGERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHR 2506

Query: 3972 GIVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGII 4031
            G+V   F  +L   E  +TG   P + K++S+ +A+   +I K+ GIR LE Q  TGG+I
Sbjct: 2507 GLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLI 2566

Query: 4032 DPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQ 4091
            +P+   RL +E A + G+ D  +   L D     +    P T+  LTY + +E+   D  
Sbjct: 2567 EPQVHSRLSIEEALQVGIIDVLIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFH 2626

Query: 4092 TGLCLLPLKE 4101
            TGL LL + E
Sbjct: 2627 TGLKLLEVSE 2636



 Score =  206 bits (525), Expect = 3e-52
 Identities = 161/593 (27%), Positives = 281/593 (47%), Gaps = 74/593 (12%)

Query: 2952 FEGLRSLVPAAELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEE 3011
            F+GLR  V A +L+E++++D    +QL+ G ++V +V +  T+ + L  A  IAG++LE 
Sbjct: 2089 FQGLRHTVTARQLVEAKLLDMRTIEQLRLGLKTVEEVQK--TLNKFLTKATSIAGLYLES 2146

Query: 3012 AGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHE 3071
              +K+S  +A ++ ++   +A+A LEAQA TG IIDP +    +V++AV  G+V PEF  
Sbjct: 2147 TKEKISFASAAERIIIDKMVALAFLEAQAATGFIIDPISGQTYSVEDAVLKGVVDPEFRI 2206

Query: 3072 KLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVP 3131
            +LL AEKA  GY   Y+ +++S+FQA++  ++ R++G  +L+AQ+++GG++DP +  RVP
Sbjct: 2207 RLLEAEKAAVGYS--YSSKTLSVFQAMENRMLDRQKGKHILEAQIASGGVIDPVRGIRVP 2264

Query: 3132 LDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLS 3191
             ++A  +G L+    + L  P ++ + + +P+  +   Y EL + C  D  +   L P  
Sbjct: 2265 PEIALQQGLLNNAILQFLHEPSSNTRVFPNPNNKQALYYSELLRMCVFDVESQCFLFPFG 2324

Query: 3192 EK-----------AARARQEELYSELQARETFEKTPVEVPV------GGFKGRTVTVWEL 3234
            E+                  +  SEL   E F++  +E  +        ++ +    +E 
Sbjct: 2325 ERNISNLNVKKTHRISVVDTKTGSELTVYEAFQRNLIEKSIYLELSGQQYQWKEAMFFES 2384

Query: 3235 I--SSEYFTAEQR------QELLRQFRTGKVTVEKVIKILITIVEEVETLRQERLSFSGL 3286
               SS   T  +        E + Q    K  V+K  + LIT+ E  ++L    +    L
Sbjct: 2385 YGHSSHMLTDTKTGLHFNINEAIEQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDL 2444

Query: 3287 RAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEK 3346
             +PV    L ASG       E++   K + ++L +  +    L+      GI    T +K
Sbjct: 2445 HSPVAGYWLTASG-------ERISVLKASRRNLVDRITALRCLEAQVSTGGIIDPLTGKK 2497

Query: 3347 VSIYEAMRRGLLRATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLS 3406
              + EA+ RGL+    A  L + +     +  P+ N+ + V EAV A ++  E+  + L 
Sbjct: 2498 YRVAEALHRGLVDEGFAQQLRQCELVITGIGHPITNKMMSVVEAVNANIINKEMGIRCLE 2557

Query: 3407 AEKAVTGYRDPYSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVA 3466
             +    G  +P   S +S+ +A+Q G++         +  IAT                 
Sbjct: 2558 FQYLTGGLIEPQVHSRLSIEEALQVGII---------DVLIAT----------------- 2591

Query: 3467 YQRGYFSEEMNRVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLL 3519
                         L D     +    P T   LTY++ LE+   D  TGL+LL
Sbjct: 2592 ------------KLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLL 2632



 Score =  114 bits (284), Expect = 3e-24
 Identities = 77/242 (31%), Positives = 122/242 (50%), Gaps = 2/242 (0%)

Query: 2638 EAGILSAEELQRLAQGHTTVDELARREDVRHYLQG--RSSIAGLLLKATNEKLSVYAALQ 2695
            E G +    +++  +G  T+ ELA     R   +    S +AG  L A+ E++SV  A +
Sbjct: 2408 EQGTIDKALVKKYQEGLITLTELADSLLSRLVPKKDLHSPVAGYWLTASGERISVLKASR 2467

Query: 2696 RQLLSPGTALILLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGY 2755
            R L+   TAL  LEAQ ++G ++DP+  ++  V EA+  G+V      +L   E  +TG 
Sbjct: 2468 RNLVDRITALRCLEAQVSTGGIIDPLTGKKYRVAEALHRGLVDEGFAQQLRQCELVITGI 2527

Query: 2756 KDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDE 2815
              P T + +S+ +A+   +I +E GIR LE Q  TGG+I+P    R+ ++ A + G  D 
Sbjct: 2528 GHPITNKMMSVVEAVNANIINKEMGIRCLEFQYLTGGLIEPQVHSRLSIEEALQVGIIDV 2587

Query: 2816 EMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKGGELVYT 2875
             +   L D     +    P T   LTY + LE+   D  TGL LL +++    G   +Y 
Sbjct: 2588 LIATKLKDQKSYVRNIICPQTKRKLTYKEALEKADFDFHTGLKLLEVSEPLMTGISSLYY 2647

Query: 2876 DS 2877
             S
Sbjct: 2648 SS 2649



 Score = 64.3 bits (155), Expect = 3e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 368 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 427
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 428 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153


>gi|221316624 dystonin isoform 4 [Homo sapiens]
          Length = 5526

 Score =  861 bits (2224), Expect = 0.0
 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 630  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 689

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 690  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 749

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 750  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 809

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 810  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 869

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 870  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 929

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 930  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 989

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 990  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1049

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1050 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1109

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1110 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1169

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1170 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1229

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1230 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1289

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1290 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1349

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1350 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1409

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1410 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1469

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1470 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1522

Query: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1434
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1523 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1581

Query: 1435 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1582 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1639

Query: 1485 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1542
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1640 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1699

Query: 1543 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1598
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1700 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1759

Query: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1648
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1760 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1818

Query: 1649 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1703
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1819 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1878

Query: 1704 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1879 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1938

Query: 1758 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1803
            S S++   +++  A      R+L     R R+L  +        + L +     EDA+  
Sbjct: 1939 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1998

Query: 1804 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1853
                     A A + L+E +A   +  + + E   AL+     ++   E+L++ AE    
Sbjct: 1999 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2058

Query: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1910
             R  L       +  +++ + +    S S  ER + L + TL +   V+   +E+L    
Sbjct: 2059 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2117

Query: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 1965
            + E +   + ++ L    ++      +  ++     A RQ  + A  E+ ++  E     
Sbjct: 2118 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2174

Query: 1966 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2019
                 +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   E
Sbjct: 2175 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2234

Query: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2078
                     E      + Q  QE      + +  L+ L    +        +++A V + 
Sbjct: 2235 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2288

Query: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
                ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   +
Sbjct: 2289 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2348

Query: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2192
                + +E  KK  E+   +  ++++     ++   L    T   K +  +      L  
Sbjct: 2349 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2407

Query: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2245
            E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  Q
Sbjct: 2408 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2462

Query: 2246 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
            EE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   LK
Sbjct: 2463 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2519

Query: 2305 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
             +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+EA
Sbjct: 2520 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2578

Query: 2349 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
            + ++ L                   ++ + +++++ + E +  + + E+     +     
Sbjct: 2579 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2638

Query: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2442
             GE      +  ++   + Q  +    Q     + + +AI +  + +  L+         
Sbjct: 2639 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2698

Query: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
            + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E 
Sbjct: 2699 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2754

Query: 2503 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
             KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ +
Sbjct: 2755 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2814

Query: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
               + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2815 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2857



 Score =  565 bits (1456), Expect = e-160
 Identities = 272/465 (58%), Positives = 368/465 (79%), Gaps = 4/465 (0%)

Query: 1   MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
           +DP+   +  +  + DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEV
Sbjct: 48  LDPA---ERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEV 104

Query: 61  LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
           LSGD+LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIIL
Sbjct: 105 LSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIIL 164

Query: 121 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
           HFQISDI V+G+SEDM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P
Sbjct: 165 HFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRP 224

Query: 181 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
            LIDMN V  Q+NL NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA 
Sbjct: 225 DLIDMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAF 283

Query: 241 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
           P+VP+  +G+ AN+++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L
Sbjct: 284 PKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYL 343

Query: 301 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
           +FKE E+P KE +K++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK
Sbjct: 344 QFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREK 403

Query: 361 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
            LR E ERLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   +
Sbjct: 404 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYI 463

Query: 421 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465
            + ++++R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 464 LECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 508



 Score =  111 bits (277), Expect = 2e-23
 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)

Query: 937  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 996
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 2665 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2724

Query: 997  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1056
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 2725 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2774

Query: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1108
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 2775 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2834

Query: 1109 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 2835 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2878

Query: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 2879 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2936

Query: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1258
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 2937 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2996

Query: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1317
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 2997 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3056

Query: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 3057 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3115

Query: 1377 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 3116 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3174

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1477
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 3175 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3233

Query: 1478 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1511
            +         +  +ESQ     E E  ++         K E E  + KQ+          
Sbjct: 3234 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3293

Query: 1512 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1544
                   + Q LE          + L +   +RA Q+Q A                    
Sbjct: 3294 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3353

Query: 1545 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601
               L   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 3354 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3412

Query: 1602 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1649
            +   +  L   RW+   N+A     Q E    VAQQ  ++L          EK+    E 
Sbjct: 3413 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3472

Query: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 3473 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3529

Query: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 3530 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3586

Query: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1820
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 3587 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3641

Query: 1821 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1874
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 3642 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3701

Query: 1875 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1922
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 3702 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3760

Query: 1923 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1975
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 3761 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3820

Query: 1976 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ  E
Sbjct: 3821 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3876

Query: 2030 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2084
            +A +   Q  +  +EL   L + QS++ QL     E E  R+  EE  + R         
Sbjct: 3877 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3936

Query: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2140
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 3937 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3996

Query: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2197
             D  +E  ++  E+ LRQ   +  E+  ++ Q+ E  +       L    + LK    E 
Sbjct: 3997 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4055

Query: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
              +    ++++ +  VQ     KL   +   EN   ++ +++     + E AEK     +
Sbjct: 4056 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4109

Query: 2257 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2310
              + +         +R L     +  + +Q+  A + ++E++  +QE     +   +EL+
Sbjct: 4110 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4169

Query: 2311 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
                +  K + ++    L    + + +   +     +  ++A  Q Q  + A  + + + 
Sbjct: 4170 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4229

Query: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
              +++ + +    D +  ++Q EE+  K  ++E   Q         +I+ ++ +H AE L
Sbjct: 4230 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4277

Query: 2427 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2474
             + + E E +K  +Q    E KL+    EE    +Q +L     AL Q         ++L
Sbjct: 4278 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4336

Query: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2530
            +  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E   +    L+ S  
Sbjct: 4337 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4392

Query: 2531 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2586
             EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +  Q L +  R  
Sbjct: 4393 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4452

Query: 2587 LA 2588
            LA
Sbjct: 4453 LA 4454



 Score = 94.0 bits (232), Expect = 3e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 928  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 981
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 3190 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3247

Query: 982  VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 3248 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3298

Query: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1093
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 3299 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3357

Query: 1094 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1153
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3358 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3410

Query: 1154 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1211
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 3411 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3470

Query: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 3471 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3529

Query: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1330
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 3530 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3588

Query: 1331 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1374
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 3589 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3648

Query: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1428
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 3649 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3708

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 3709 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3763

Query: 1489 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1537
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 3764 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3823

Query: 1538 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1573
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 3824 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3883

Query: 1574 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1615
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 3884 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3943

Query: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 3944 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4003

Query: 1675 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1728
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 4004 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4063

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1783
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 4064 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4113

Query: 1784 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 4114 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4164

Query: 1840 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 4165 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4212

Query: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 4213 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4268

Query: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 4269 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4326

Query: 2019 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 4327 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4385

Query: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 4386 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4432

Query: 2130 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 4433 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4490

Query: 2184 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 4491 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4546

Query: 2240 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2288
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 4547 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4606

Query: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 4607 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4665

Query: 2349 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 4666 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4717

Query: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2463
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 4718 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4759

Query: 2464 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 4760 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4819

Query: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2564
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 4820 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4879

Query: 2565 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2601
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 4880 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4926



 Score = 85.1 bits (209), Expect = 1e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 1104 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1158
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 3697 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3741

Query: 1159 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 3742 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3801

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 3802 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3858

Query: 1276 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1321
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 3859 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3918

Query: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 3919 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3978

Query: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1433
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 3979 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4037

Query: 1434 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1486
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 4038 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4093

Query: 1487 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1536
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 4094 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4152

Query: 1537 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 4153 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4211

Query: 1592 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1644
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 4212 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4271

Query: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 4272 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4323

Query: 1705 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1758
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 4324 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4383

Query: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 4384 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4433

Query: 1819 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1867
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 4434 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4493

Query: 1868 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1918
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 4494 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4551

Query: 1919 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 4552 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4604

Query: 1975 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2019
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 4605 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4664

Query: 2020 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 4665 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4722

Query: 2073 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 4723 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4781

Query: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 4782 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4836

Query: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2235
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 4837 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4896

Query: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2287
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 4897 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4956

Query: 2288 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2342
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 4957 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5016

Query: 2343 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2395
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 5017 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5076

Query: 2396 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 5077 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5130

Query: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 5131 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5167



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 490  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 542
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 3325 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3384

Query: 543  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 598
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3385 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3443

Query: 599  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 652
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3444 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3503

Query: 653  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 691
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3504 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3561

Query: 692  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 740
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3562 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3620

Query: 741  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 788
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3621 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3680

Query: 789  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 842
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3681 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3739

Query: 843  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 897
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3740 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3799

Query: 898  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 941
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3800 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3859

Query: 942  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 990
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 3860 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3919

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 3920 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3977

Query: 1051 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 3978 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4027

Query: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1164
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 4028 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4080

Query: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 4081 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4139

Query: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 4140 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4188

Query: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 4189 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4240

Query: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 4241 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4297

Query: 1404 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1454
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 4298 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4357

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1513
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 4358 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4414

Query: 1514 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 4415 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4468

Query: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1611
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 4469 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4528

Query: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 4529 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4588

Query: 1672 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 4589 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4648

Query: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 4649 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4703

Query: 1788 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1841
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 4704 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4763

Query: 1842 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 4764 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4823

Query: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 4824 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4869

Query: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 4870 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4928

Query: 2021 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 4929 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4984

Query: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2128
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 4985 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5043

Query: 2129 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 5044 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5095

Query: 2188 QRLKAEATEAARQRSQVEEELFSVR 2212
            Q++   A E  R+ +   + L  +R
Sbjct: 5096 QQVWLLALERRRKLNDALDRLEELR 5120



 Score = 69.3 bits (168), Expect = 8e-11
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1047
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 4247 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4299

Query: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1103
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 4300 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4356

Query: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4357 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4407

Query: 1164 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1222
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 4408 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4465

Query: 1223 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1263
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 4466 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4525

Query: 1264 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1323
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 4526 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4579

Query: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 4580 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4628

Query: 1384 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1439
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 4629 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4688

Query: 1440 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1495
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 4689 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4748

Query: 1496 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 4749 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4804

Query: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 4805 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4847

Query: 1614 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 4848 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4906

Query: 1670 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 4907 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4966

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1781
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 4967 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5026

Query: 1782 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1831
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 5027 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5086

Query: 1832 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1870
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 5087 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5146

Query: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1929
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 5147 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5205

Query: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 5206 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5242



 Score = 40.0 bits (92), Expect = 0.053
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 1067 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1125

Query: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 1126 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1165

Query: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 1166 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1224

Query: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 1225 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1283

Query: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 1284 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1343

Query: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 1344 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1394

Query: 2499 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 1395 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1440

Query: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 1441 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1500

Query: 2616 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2645
            ++ +        +++  ++ LQ   +  A+
Sbjct: 1501 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1530



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 342  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 401
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4622 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4674

Query: 402  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 461
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4675 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4720

Query: 462  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 513
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4721 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4778

Query: 514  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 573
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4779 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4833

Query: 574  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 619
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4834 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4889

Query: 620  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 666
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 4890 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4938



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 4435 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 5422 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5472



 Score = 32.7 bits (73), Expect = 8.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 483  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 535
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4630 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4689

Query: 536  HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 590
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4690 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4749

Query: 591  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 642
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4750 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4806

Query: 643  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 702
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4807 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4866

Query: 703  FQFFSDVREA 712
             + F  V  A
Sbjct: 4867 AEEFHSVVHA 4876


>gi|221316622 dystonin isoform 3 [Homo sapiens]
          Length = 5537

 Score =  861 bits (2224), Expect = 0.0
 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 641  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 700

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 701  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 760

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 761  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 820

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 821  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 880

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 881  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 940

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 941  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1000

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1001 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1060

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1061 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1120

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1121 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1180

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1181 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1240

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1241 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1300

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1301 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1360

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1361 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1420

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1421 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1480

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1481 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1533

Query: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1434
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1534 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1592

Query: 1435 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1593 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1650

Query: 1485 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1542
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1651 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1710

Query: 1543 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1598
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1711 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1770

Query: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1648
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1771 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1829

Query: 1649 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1703
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1830 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1889

Query: 1704 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1890 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1949

Query: 1758 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1803
            S S++   +++  A      R+L     R R+L  +        + L +     EDA+  
Sbjct: 1950 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2009

Query: 1804 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1853
                     A A + L+E +A   +  + + E   AL+     ++   E+L++ AE    
Sbjct: 2010 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2069

Query: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1910
             R  L       +  +++ + +    S S  ER + L + TL +   V+   +E+L    
Sbjct: 2070 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2128

Query: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 1965
            + E +   + ++ L    ++      +  ++     A RQ  + A  E+ ++  E     
Sbjct: 2129 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2185

Query: 1966 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2019
                 +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   E
Sbjct: 2186 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2245

Query: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2078
                     E      + Q  QE      + +  L+ L    +        +++A V + 
Sbjct: 2246 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2299

Query: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
                ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   +
Sbjct: 2300 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2359

Query: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2192
                + +E  KK  E+   +  ++++     ++   L    T   K +  +      L  
Sbjct: 2360 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2418

Query: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2245
            E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  Q
Sbjct: 2419 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2473

Query: 2246 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
            EE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   LK
Sbjct: 2474 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2530

Query: 2305 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
             +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+EA
Sbjct: 2531 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2589

Query: 2349 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
            + ++ L                   ++ + +++++ + E +  + + E+     +     
Sbjct: 2590 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2649

Query: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2442
             GE      +  ++   + Q  +    Q     + + +AI +  + +  L+         
Sbjct: 2650 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2709

Query: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
            + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E 
Sbjct: 2710 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2765

Query: 2503 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
             KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ +
Sbjct: 2766 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2825

Query: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
               + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2826 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2868



 Score =  565 bits (1456), Expect = e-160
 Identities = 272/465 (58%), Positives = 368/465 (79%), Gaps = 4/465 (0%)

Query: 1   MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
           +DP+   +  +  + DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEV
Sbjct: 59  LDPA---ERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEV 115

Query: 61  LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
           LSGD+LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIIL
Sbjct: 116 LSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIIL 175

Query: 121 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
           HFQISDI V+G+SEDM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P
Sbjct: 176 HFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRP 235

Query: 181 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
            LIDMN V  Q+NL NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA 
Sbjct: 236 DLIDMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAF 294

Query: 241 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
           P+VP+  +G+ AN+++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L
Sbjct: 295 PKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYL 354

Query: 301 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
           +FKE E+P KE +K++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK
Sbjct: 355 QFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREK 414

Query: 361 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
            LR E ERLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   +
Sbjct: 415 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYI 474

Query: 421 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465
            + ++++R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 475 LECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 519



 Score =  111 bits (277), Expect = 2e-23
 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)

Query: 937  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 996
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 2676 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2735

Query: 997  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1056
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 2736 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2785

Query: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1108
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 2786 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2845

Query: 1109 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 2846 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2889

Query: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 2890 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2947

Query: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1258
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 2948 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3007

Query: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1317
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 3008 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3067

Query: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 3068 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3126

Query: 1377 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 3127 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3185

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1477
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 3186 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3244

Query: 1478 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1511
            +         +  +ESQ     E E  ++         K E E  + KQ+          
Sbjct: 3245 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3304

Query: 1512 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1544
                   + Q LE          + L +   +RA Q+Q A                    
Sbjct: 3305 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3364

Query: 1545 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601
               L   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 3365 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3423

Query: 1602 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1649
            +   +  L   RW+   N+A     Q E    VAQQ  ++L          EK+    E 
Sbjct: 3424 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3483

Query: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 3484 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3540

Query: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3597

Query: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1820
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 3598 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3652

Query: 1821 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1874
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 3653 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3712

Query: 1875 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1922
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 3713 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3771

Query: 1923 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1975
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 3772 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3831

Query: 1976 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ  E
Sbjct: 3832 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3887

Query: 2030 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2084
            +A +   Q  +  +EL   L + QS++ QL     E E  R+  EE  + R         
Sbjct: 3888 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3947

Query: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2140
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 3948 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 4007

Query: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2197
             D  +E  ++  E+ LRQ   +  E+  ++ Q+ E  +       L    + LK    E 
Sbjct: 4008 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4066

Query: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
              +    ++++ +  VQ     KL   +   EN   ++ +++     + E AEK     +
Sbjct: 4067 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4120

Query: 2257 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2310
              + +         +R L     +  + +Q+  A + ++E++  +QE     +   +EL+
Sbjct: 4121 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4180

Query: 2311 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
                +  K + ++    L    + + +   +     +  ++A  Q Q  + A  + + + 
Sbjct: 4181 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4240

Query: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
              +++ + +    D +  ++Q EE+  K  ++E   Q         +I+ ++ +H AE L
Sbjct: 4241 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4288

Query: 2427 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2474
             + + E E +K  +Q    E KL+    EE    +Q +L     AL Q         ++L
Sbjct: 4289 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4347

Query: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2530
            +  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E   +    L+ S  
Sbjct: 4348 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4403

Query: 2531 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2586
             EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +  Q L +  R  
Sbjct: 4404 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4463

Query: 2587 LA 2588
            LA
Sbjct: 4464 LA 4465



 Score = 94.0 bits (232), Expect = 3e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 928  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 981
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 3201 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3258

Query: 982  VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 3259 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3309

Query: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1093
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 3310 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3368

Query: 1094 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1153
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3369 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3421

Query: 1154 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1211
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 3422 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3481

Query: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 3482 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3540

Query: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1330
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 3541 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3599

Query: 1331 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1374
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 3600 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3659

Query: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1428
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 3660 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3719

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 3720 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3774

Query: 1489 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1537
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 3775 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3834

Query: 1538 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1573
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 3835 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3894

Query: 1574 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1615
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 3895 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3954

Query: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 3955 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4014

Query: 1675 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1728
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 4015 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4074

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1783
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 4075 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4124

Query: 1784 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 4125 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4175

Query: 1840 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 4176 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4223

Query: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 4224 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4279

Query: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 4280 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4337

Query: 2019 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 4338 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4396

Query: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 4397 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4443

Query: 2130 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 4444 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4501

Query: 2184 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 4502 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4557

Query: 2240 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2288
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 4558 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4617

Query: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 4618 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4676

Query: 2349 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 4677 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4728

Query: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2463
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 4729 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4770

Query: 2464 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 4771 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4830

Query: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2564
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 4831 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4890

Query: 2565 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2601
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 4891 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4937



 Score = 85.1 bits (209), Expect = 1e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 1104 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1158
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 3708 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3752

Query: 1159 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 3753 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3812

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 3813 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3869

Query: 1276 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1321
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 3870 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3929

Query: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 3930 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3989

Query: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1433
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 3990 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4048

Query: 1434 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1486
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 4049 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4104

Query: 1487 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1536
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 4105 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4163

Query: 1537 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 4164 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4222

Query: 1592 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1644
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 4223 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4282

Query: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 4283 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4334

Query: 1705 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1758
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 4335 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4394

Query: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 4395 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4444

Query: 1819 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1867
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 4445 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4504

Query: 1868 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1918
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 4505 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4562

Query: 1919 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 4563 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4615

Query: 1975 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2019
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 4616 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4675

Query: 2020 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 4676 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4733

Query: 2073 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 4734 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4792

Query: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 4793 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4847

Query: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2235
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 4848 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4907

Query: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2287
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 4908 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4967

Query: 2288 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2342
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 4968 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5027

Query: 2343 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2395
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 5028 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5087

Query: 2396 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 5088 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5141

Query: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 5142 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5178



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 490  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 542
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 3336 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3395

Query: 543  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 598
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3396 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3454

Query: 599  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 652
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3455 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3514

Query: 653  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 691
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3515 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3572

Query: 692  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 740
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3573 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3631

Query: 741  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 788
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3632 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3691

Query: 789  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 842
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3692 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3750

Query: 843  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 897
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3751 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3810

Query: 898  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 941
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3811 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3870

Query: 942  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 990
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 3871 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3930

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 3931 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3988

Query: 1051 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 3989 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4038

Query: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1164
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 4039 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4091

Query: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 4092 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4150

Query: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 4151 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4199

Query: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 4200 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4251

Query: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 4252 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4308

Query: 1404 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1454
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 4309 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4368

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1513
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 4369 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4425

Query: 1514 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 4426 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4479

Query: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1611
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 4480 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4539

Query: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 4540 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4599

Query: 1672 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 4600 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4659

Query: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 4660 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4714

Query: 1788 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1841
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 4715 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4774

Query: 1842 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 4775 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4834

Query: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 4835 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4880

Query: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 4881 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4939

Query: 2021 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 4940 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4995

Query: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2128
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 4996 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5054

Query: 2129 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 5055 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5106

Query: 2188 QRLKAEATEAARQRSQVEEELFSVR 2212
            Q++   A E  R+ +   + L  +R
Sbjct: 5107 QQVWLLALERRRKLNDALDRLEELR 5131



 Score = 69.3 bits (168), Expect = 8e-11
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1047
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 4258 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4310

Query: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1103
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 4311 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4367

Query: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4368 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4418

Query: 1164 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1222
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 4419 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4476

Query: 1223 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1263
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 4477 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4536

Query: 1264 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1323
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 4537 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4590

Query: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 4591 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4639

Query: 1384 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1439
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 4640 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4699

Query: 1440 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1495
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 4700 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4759

Query: 1496 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 4760 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4815

Query: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 4816 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4858

Query: 1614 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 4859 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4917

Query: 1670 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 4918 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4977

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1781
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 4978 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5037

Query: 1782 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1831
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 5038 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5097

Query: 1832 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1870
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 5098 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5157

Query: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1929
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 5158 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5216

Query: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 5217 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5253



 Score = 40.0 bits (92), Expect = 0.053
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 1078 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1136

Query: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 1137 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1176

Query: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 1177 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1235

Query: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 1236 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1294

Query: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 1295 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1354

Query: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 1355 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1405

Query: 2499 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 1406 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1451

Query: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 1452 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1511

Query: 2616 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2645
            ++ +        +++  ++ LQ   +  A+
Sbjct: 1512 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1541



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 342  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 401
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4633 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4685

Query: 402  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 461
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4686 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4731

Query: 462  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 513
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4732 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4789

Query: 514  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 573
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4790 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4844

Query: 574  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 619
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4845 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4900

Query: 620  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 666
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 4901 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4949



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 4435 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 5433 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5483



 Score = 32.7 bits (73), Expect = 8.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 483  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 535
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4641 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4700

Query: 536  HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 590
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4701 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4760

Query: 591  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 642
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4761 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4817

Query: 643  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 702
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4818 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4877

Query: 703  FQFFSDVREA 712
             + F  V  A
Sbjct: 4878 AEEFHSVVHA 4887


>gi|221316618 dystonin isoform 2 [Homo sapiens]
          Length = 5675

 Score =  861 bits (2224), Expect = 0.0
 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 779  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 838

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 839  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 898

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 899  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 958

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 959  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 1018

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 1019 HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 1078

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 1079 IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 1138

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 1139 NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1198

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1199 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1258

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1259 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1318

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1319 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1378

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1379 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1438

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1439 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1498

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1499 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1558

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1559 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1618

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1619 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1671

Query: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1434
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1672 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1730

Query: 1435 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1731 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1788

Query: 1485 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1542
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1789 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1848

Query: 1543 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1598
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1849 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1908

Query: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1648
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1909 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1967

Query: 1649 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1703
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1968 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 2027

Query: 1704 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 2028 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 2087

Query: 1758 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1803
            S S++   +++  A      R+L     R R+L  +        + L +     EDA+  
Sbjct: 2088 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 2147

Query: 1804 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1853
                     A A + L+E +A   +  + + E   AL+     ++   E+L++ AE    
Sbjct: 2148 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2207

Query: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1910
             R  L       +  +++ + +    S S  ER + L + TL +   V+   +E+L    
Sbjct: 2208 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2266

Query: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 1965
            + E +   + ++ L    ++      +  ++     A RQ  + A  E+ ++  E     
Sbjct: 2267 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2323

Query: 1966 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2019
                 +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   E
Sbjct: 2324 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2383

Query: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2078
                     E      + Q  QE      + +  L+ L    +        +++A V + 
Sbjct: 2384 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2437

Query: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
                ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   +
Sbjct: 2438 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2497

Query: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2192
                + +E  KK  E+   +  ++++     ++   L    T   K +  +      L  
Sbjct: 2498 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2556

Query: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2245
            E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  Q
Sbjct: 2557 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2611

Query: 2246 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
            EE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   LK
Sbjct: 2612 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2668

Query: 2305 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
             +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+EA
Sbjct: 2669 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2727

Query: 2349 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
            + ++ L                   ++ + +++++ + E +  + + E+     +     
Sbjct: 2728 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2787

Query: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2442
             GE      +  ++   + Q  +    Q     + + +AI +  + +  L+         
Sbjct: 2788 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2847

Query: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
            + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E 
Sbjct: 2848 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2903

Query: 2503 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
             KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ +
Sbjct: 2904 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2963

Query: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
               + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2964 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 3006



 Score =  565 bits (1456), Expect = e-160
 Identities = 272/465 (58%), Positives = 368/465 (79%), Gaps = 4/465 (0%)

Query: 1   MDPSRAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEV 60
           +DP+   +  +  + DERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEV
Sbjct: 197 LDPA---ERAVLRIADERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEV 253

Query: 61  LSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 120
           LSGD+LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIIL
Sbjct: 254 LSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIIL 313

Query: 121 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP 180
           HFQISDI V+G+SEDM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P
Sbjct: 314 HFQISDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRP 373

Query: 181 LLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAM 240
            LIDMN V  Q+NL NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA 
Sbjct: 374 DLIDMNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAF 432

Query: 241 PRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFL 300
           P+VP+  +G+ AN+++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L
Sbjct: 433 PKVPEGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYL 492

Query: 301 KFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREK 360
           +FKE E+P KE +K++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK
Sbjct: 493 QFKETEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREK 552

Query: 361 QLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDL 420
            LR E ERLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   +
Sbjct: 553 ALRPEVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYI 612

Query: 421 DKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465
            + ++++R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 613 LECENLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 657



 Score =  111 bits (277), Expect = 2e-23
 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)

Query: 937  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 996
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 2814 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2873

Query: 997  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1056
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 2874 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2923

Query: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1108
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 2924 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2983

Query: 1109 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 2984 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 3027

Query: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 3028 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 3085

Query: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1258
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 3086 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 3145

Query: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1317
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 3146 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3205

Query: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 3206 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3264

Query: 1377 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 3265 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3323

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1477
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 3324 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3382

Query: 1478 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1511
            +         +  +ESQ     E E  ++         K E E  + KQ+          
Sbjct: 3383 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3442

Query: 1512 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1544
                   + Q LE          + L +   +RA Q+Q A                    
Sbjct: 3443 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3502

Query: 1545 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601
               L   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 3503 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3561

Query: 1602 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1649
            +   +  L   RW+   N+A     Q E    VAQQ  ++L          EK+    E 
Sbjct: 3562 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3621

Query: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 3622 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3678

Query: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 3679 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3735

Query: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1820
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 3736 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3790

Query: 1821 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1874
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 3791 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3850

Query: 1875 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1922
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 3851 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3909

Query: 1923 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1975
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 3910 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3969

Query: 1976 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ  E
Sbjct: 3970 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 4025

Query: 2030 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2084
            +A +   Q  +  +EL   L + QS++ QL     E E  R+  EE  + R         
Sbjct: 4026 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 4085

Query: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2140
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 4086 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 4145

Query: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2197
             D  +E  ++  E+ LRQ   +  E+  ++ Q+ E  +       L    + LK    E 
Sbjct: 4146 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4204

Query: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
              +    ++++ +  VQ     KL   +   EN   ++ +++     + E AEK     +
Sbjct: 4205 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4258

Query: 2257 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2310
              + +         +R L     +  + +Q+  A + ++E++  +QE     +   +EL+
Sbjct: 4259 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4318

Query: 2311 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
                +  K + ++    L    + + +   +     +  ++A  Q Q  + A  + + + 
Sbjct: 4319 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4378

Query: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
              +++ + +    D +  ++Q EE+  K  ++E   Q         +I+ ++ +H AE L
Sbjct: 4379 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4426

Query: 2427 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2474
             + + E E +K  +Q    E KL+    EE    +Q +L     AL Q         ++L
Sbjct: 4427 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4485

Query: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2530
            +  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E   +    L+ S  
Sbjct: 4486 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4541

Query: 2531 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2586
             EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +  Q L +  R  
Sbjct: 4542 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4601

Query: 2587 LA 2588
            LA
Sbjct: 4602 LA 4603



 Score = 94.0 bits (232), Expect = 3e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 928  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 981
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 3339 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3396

Query: 982  VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 3397 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3447

Query: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1093
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 3448 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3506

Query: 1094 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1153
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3507 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3559

Query: 1154 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1211
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 3560 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3619

Query: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 3620 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3678

Query: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1330
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 3679 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3737

Query: 1331 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1374
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 3738 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3797

Query: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1428
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 3798 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3857

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 3858 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3912

Query: 1489 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1537
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 3913 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3972

Query: 1538 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1573
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 3973 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 4032

Query: 1574 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1615
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 4033 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 4092

Query: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 4093 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 4152

Query: 1675 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1728
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 4153 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4212

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1783
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 4213 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4262

Query: 1784 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 4263 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4313

Query: 1840 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 4314 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4361

Query: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 4362 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4417

Query: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 4418 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4475

Query: 2019 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 4476 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4534

Query: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 4535 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4581

Query: 2130 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 4582 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4639

Query: 2184 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 4640 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4695

Query: 2240 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2288
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 4696 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4755

Query: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 4756 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4814

Query: 2349 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 4815 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4866

Query: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2463
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 4867 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4908

Query: 2464 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 4909 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4968

Query: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2564
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 4969 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 5028

Query: 2565 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2601
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 5029 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 5075



 Score = 85.1 bits (209), Expect = 1e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 1104 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1158
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 3846 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3890

Query: 1159 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 3891 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3950

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 3951 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 4007

Query: 1276 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1321
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 4008 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 4067

Query: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 4068 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 4127

Query: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1433
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 4128 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4186

Query: 1434 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1486
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 4187 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4242

Query: 1487 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1536
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 4243 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4301

Query: 1537 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 4302 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4360

Query: 1592 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1644
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 4361 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4420

Query: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 4421 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4472

Query: 1705 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1758
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 4473 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4532

Query: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 4533 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4582

Query: 1819 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1867
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 4583 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4642

Query: 1868 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1918
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 4643 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4700

Query: 1919 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 4701 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4753

Query: 1975 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2019
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 4754 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4813

Query: 2020 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 4814 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4871

Query: 2073 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 4872 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4930

Query: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 4931 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4985

Query: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2235
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 4986 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 5045

Query: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2287
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 5046 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 5105

Query: 2288 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2342
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 5106 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 5165

Query: 2343 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2395
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 5166 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5225

Query: 2396 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 5226 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5279

Query: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 5280 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5316



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 490  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 542
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 3474 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3533

Query: 543  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 598
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3534 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3592

Query: 599  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 652
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3593 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3652

Query: 653  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 691
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3653 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3710

Query: 692  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 740
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3711 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3769

Query: 741  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 788
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3770 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3829

Query: 789  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 842
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3830 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3888

Query: 843  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 897
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3889 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3948

Query: 898  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 941
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3949 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 4008

Query: 942  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 990
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 4009 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 4068

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 4069 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 4126

Query: 1051 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 4127 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 4176

Query: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1164
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 4177 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4229

Query: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 4230 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4288

Query: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 4289 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4337

Query: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 4338 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4389

Query: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 4390 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4446

Query: 1404 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1454
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 4447 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4506

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1513
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 4507 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4563

Query: 1514 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 4564 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4617

Query: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1611
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 4618 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4677

Query: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 4678 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4737

Query: 1672 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 4738 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4797

Query: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 4798 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4852

Query: 1788 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1841
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 4853 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4912

Query: 1842 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 4913 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4972

Query: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 4973 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 5018

Query: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 5019 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 5077

Query: 2021 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 5078 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 5133

Query: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2128
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 5134 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5192

Query: 2129 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 5193 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5244

Query: 2188 QRLKAEATEAARQRSQVEEELFSVR 2212
            Q++   A E  R+ +   + L  +R
Sbjct: 5245 QQVWLLALERRRKLNDALDRLEELR 5269



 Score = 69.3 bits (168), Expect = 8e-11
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1047
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 4396 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4448

Query: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1103
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 4449 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4505

Query: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4506 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4556

Query: 1164 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1222
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 4557 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4614

Query: 1223 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1263
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 4615 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4674

Query: 1264 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1323
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 4675 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4728

Query: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 4729 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4777

Query: 1384 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1439
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 4778 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4837

Query: 1440 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1495
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 4838 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4897

Query: 1496 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 4898 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4953

Query: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 4954 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4996

Query: 1614 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 4997 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 5055

Query: 1670 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 5056 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 5115

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1781
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 5116 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 5175

Query: 1782 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1831
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 5176 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5235

Query: 1832 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1870
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 5236 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5295

Query: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1929
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 5296 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5354

Query: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 5355 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5391



 Score = 40.0 bits (92), Expect = 0.053
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 1216 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1274

Query: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 1275 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1314

Query: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 1315 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1373

Query: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 1374 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1432

Query: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 1433 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1492

Query: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 1493 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1543

Query: 2499 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 1544 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1589

Query: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 1590 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1649

Query: 2616 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2645
            ++ +        +++  ++ LQ   +  A+
Sbjct: 1650 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1679



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 342  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 401
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4771 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4823

Query: 402  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 461
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4824 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4869

Query: 462  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 513
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4870 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4927

Query: 514  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 573
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4928 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4982

Query: 574  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 619
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4983 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 5038

Query: 620  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 666
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 5039 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 5087



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 4435 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 5571 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5621



 Score = 32.7 bits (73), Expect = 8.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 483  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 535
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4779 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4838

Query: 536  HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 590
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4839 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4898

Query: 591  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 642
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4899 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4955

Query: 643  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 702
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4956 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 5015

Query: 703  FQFFSDVREA 712
             + F  V  A
Sbjct: 5016 AEEFHSVVHA 5025


>gi|34577047 dystonin isoform 1 [Homo sapiens]
          Length = 5497

 Score =  861 bits (2224), Expect = 0.0
 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 601  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 660

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 661  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 720

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 721  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 780

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 781  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 840

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 841  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 900

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 901  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 960

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 961  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 1020

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 1021 EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 1080

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 1081 NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 1140

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 1141 SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 1200

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 1201 VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 1260

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 1261 KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 1320

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 1321 PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1380

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1381 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1440

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1441 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1493

Query: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1434
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1494 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1552

Query: 1435 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1553 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1610

Query: 1485 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1542
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1611 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1670

Query: 1543 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1598
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1671 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1730

Query: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1648
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1731 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1789

Query: 1649 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1703
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1790 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1849

Query: 1704 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1850 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1909

Query: 1758 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1803
            S S++   +++  A      R+L     R R+L  +        + L +     EDA+  
Sbjct: 1910 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1969

Query: 1804 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1853
                     A A + L+E +A   +  + + E   AL+     ++   E+L++ AE    
Sbjct: 1970 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 2029

Query: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1910
             R  L       +  +++ + +    S S  ER + L + TL +   V+   +E+L    
Sbjct: 2030 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 2088

Query: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 1965
            + E +   + ++ L    ++      +  ++     A RQ  + A  E+ ++  E     
Sbjct: 2089 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 2145

Query: 1966 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2019
                 +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   E
Sbjct: 2146 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 2205

Query: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2078
                     E      + Q  QE      + +  L+ L    +        +++A V + 
Sbjct: 2206 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 2259

Query: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
                ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   +
Sbjct: 2260 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 2319

Query: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2192
                + +E  KK  E+   +  ++++     ++   L    T   K +  +      L  
Sbjct: 2320 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2378

Query: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2245
            E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  Q
Sbjct: 2379 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2433

Query: 2246 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
            EE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   LK
Sbjct: 2434 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2490

Query: 2305 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
             +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+EA
Sbjct: 2491 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2549

Query: 2349 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
            + ++ L                   ++ + +++++ + E +  + + E+     +     
Sbjct: 2550 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2609

Query: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2442
             GE      +  ++   + Q  +    Q     + + +AI +  + +  L+         
Sbjct: 2610 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2669

Query: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
            + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E 
Sbjct: 2670 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2725

Query: 2503 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
             KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ +
Sbjct: 2726 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2785

Query: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
               + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2786 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2828



 Score =  567 bits (1462), Expect = e-161
 Identities = 272/461 (59%), Positives = 367/461 (79%), Gaps = 1/461 (0%)

Query: 5   RAIQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGD 64
           +A ++ +   KDERD+VQKKTFTKW+N+HL+K ++H++DLYEDLRDGHNLISLLEVLSGD
Sbjct: 20  QAYEDVLERYKDERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGD 79

Query: 65  SLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI 124
           +LPREKGRMRFH+LQNVQIALDYL+ RQVKLVNIRNDDI DGNPKLTLGLIWTIILHFQI
Sbjct: 80  TLPREKGRMRFHRLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQI 139

Query: 125 SDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184
           SDI V+G+SEDM+AKE+LLLW+Q+  EGY G+RC+NFT+ WRDG+LFNAIIH+++P LID
Sbjct: 140 SDIHVTGESEDMSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLID 199

Query: 185 MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244
           MN V  Q+NL NL+ AF VAE+ +GV RLLDPEDVDV  PDEKS+ITYVSSLYDA P+VP
Sbjct: 200 MNTVAVQSNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPKVP 258

Query: 245 DVQDGVRANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKE 304
           +  +G+ AN+++++W EY+ +V  L+QW+RHH     ER FP++  E++ L++Q+L+FKE
Sbjct: 259 EGGEGIGANDVEVKWIEYQNMVNYLIQWIRHHVTTMSERTFPNNPVELKALYNQYLQFKE 318

Query: 305 MELPAKEADKNRSKGIYQSLEGAVQAGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLRS 364
            E+P KE +K++ K +Y+ LE  ++ G++K+  GYHP D+EKEWGKL +A+LEREK LR 
Sbjct: 319 TEIPPKETEKSKIKRLYKLLEIWIEFGRIKLLQGYHPNDIEKEWGKLIIAMLEREKALRP 378

Query: 365 EFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKAD 424
           E ERLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + +
Sbjct: 379 EVERLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECE 438

Query: 425 SMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465
           +++R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 439 NLLRQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 479



 Score =  111 bits (277), Expect = 2e-23
 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)

Query: 937  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 996
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 2636 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2695

Query: 997  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1056
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 2696 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2745

Query: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1108
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 2746 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2805

Query: 1109 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 2806 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2849

Query: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 2850 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2907

Query: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1258
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 2908 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2967

Query: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1317
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 2968 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 3027

Query: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 3028 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 3086

Query: 1377 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 3087 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 3145

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1477
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 3146 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 3204

Query: 1478 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1511
            +         +  +ESQ     E E  ++         K E E  + KQ+          
Sbjct: 3205 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 3264

Query: 1512 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1544
                   + Q LE          + L +   +RA Q+Q A                    
Sbjct: 3265 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 3324

Query: 1545 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601
               L   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 3325 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3383

Query: 1602 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1649
            +   +  L   RW+   N+A     Q E    VAQQ  ++L          EK+    E 
Sbjct: 3384 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3443

Query: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 3444 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3500

Query: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 3501 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3557

Query: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1820
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 3558 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3612

Query: 1821 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1874
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 3613 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3672

Query: 1875 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1922
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 3673 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3731

Query: 1923 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1975
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 3732 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3791

Query: 1976 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ  E
Sbjct: 3792 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3847

Query: 2030 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2084
            +A +   Q  +  +EL   L + QS++ QL     E E  R+  EE  + R         
Sbjct: 3848 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3907

Query: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2140
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 3908 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3967

Query: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2197
             D  +E  ++  E+ LRQ   +  E+  ++ Q+ E  +       L    + LK    E 
Sbjct: 3968 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 4026

Query: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
              +    ++++ +  VQ     KL   +   EN   ++ +++     + E AEK     +
Sbjct: 4027 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 4080

Query: 2257 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2310
              + +         +R L     +  + +Q+  A + ++E++  +QE     +   +EL+
Sbjct: 4081 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 4140

Query: 2311 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
                +  K + ++    L    + + +   +     +  ++A  Q Q  + A  + + + 
Sbjct: 4141 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 4200

Query: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
              +++ + +    D +  ++Q EE+  K  ++E   Q         +I+ ++ +H AE L
Sbjct: 4201 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 4248

Query: 2427 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2474
             + + E E +K  +Q    E KL+    EE    +Q +L     AL Q         ++L
Sbjct: 4249 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 4307

Query: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2530
            +  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E   +    L+ S  
Sbjct: 4308 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4363

Query: 2531 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2586
             EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +  Q L +  R  
Sbjct: 4364 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4423

Query: 2587 LA 2588
            LA
Sbjct: 4424 LA 4425



 Score = 94.0 bits (232), Expect = 3e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 928  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 981
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 3161 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 3218

Query: 982  VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 3219 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 3269

Query: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1093
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 3270 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3328

Query: 1094 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1153
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3329 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3381

Query: 1154 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1211
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 3382 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3441

Query: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 3442 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3500

Query: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1330
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 3501 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3559

Query: 1331 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1374
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 3560 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3619

Query: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1428
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 3620 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3679

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 3680 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3734

Query: 1489 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1537
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 3735 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3794

Query: 1538 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1573
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 3795 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3854

Query: 1574 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1615
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 3855 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3914

Query: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 3915 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3974

Query: 1675 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1728
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 3975 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 4034

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1783
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 4035 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 4084

Query: 1784 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 4085 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 4135

Query: 1840 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 4136 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 4183

Query: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 4184 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 4239

Query: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 4240 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 4297

Query: 2019 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 4298 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4356

Query: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 4357 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4403

Query: 2130 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 4404 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4461

Query: 2184 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 4462 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4517

Query: 2240 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2288
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 4518 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4577

Query: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 4578 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4636

Query: 2349 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 4637 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4688

Query: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2463
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 4689 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4730

Query: 2464 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 4731 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4790

Query: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2564
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 4791 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4850

Query: 2565 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2601
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 4851 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4897



 Score = 85.1 bits (209), Expect = 1e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 1104 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1158
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 3668 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3712

Query: 1159 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 3713 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3772

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 3773 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3829

Query: 1276 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1321
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 3830 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3889

Query: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 3890 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3949

Query: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1433
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 3950 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 4008

Query: 1434 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1486
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 4009 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 4064

Query: 1487 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1536
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 4065 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 4123

Query: 1537 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 4124 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 4182

Query: 1592 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1644
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 4183 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 4242

Query: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 4243 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 4294

Query: 1705 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1758
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 4295 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4354

Query: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 4355 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4404

Query: 1819 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1867
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 4405 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4464

Query: 1868 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1918
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 4465 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4522

Query: 1919 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 4523 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4575

Query: 1975 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2019
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 4576 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4635

Query: 2020 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 4636 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4693

Query: 2073 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 4694 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4752

Query: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 4753 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4807

Query: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2235
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 4808 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4867

Query: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2287
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 4868 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4927

Query: 2288 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2342
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 4928 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4987

Query: 2343 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2395
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 4988 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 5047

Query: 2396 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 5048 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 5101

Query: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 5102 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 5138



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 490  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 542
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 3296 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3355

Query: 543  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 598
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3356 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3414

Query: 599  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 652
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3415 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3474

Query: 653  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 691
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3475 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3532

Query: 692  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 740
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3533 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3591

Query: 741  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 788
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3592 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3651

Query: 789  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 842
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3652 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3710

Query: 843  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 897
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3711 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3770

Query: 898  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 941
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3771 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3830

Query: 942  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 990
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 3831 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3890

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 3891 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3948

Query: 1051 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 3949 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3998

Query: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1164
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 3999 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 4051

Query: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 4052 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 4110

Query: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 4111 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 4159

Query: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 4160 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 4211

Query: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 4212 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 4268

Query: 1404 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1454
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 4269 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4328

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1513
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 4329 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4385

Query: 1514 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 4386 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4439

Query: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1611
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 4440 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4499

Query: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 4500 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4559

Query: 1672 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 4560 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4619

Query: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 4620 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4674

Query: 1788 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1841
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 4675 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4734

Query: 1842 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 4735 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4794

Query: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 4795 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4840

Query: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 4841 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4899

Query: 2021 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 4900 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4955

Query: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2128
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 4956 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 5014

Query: 2129 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 5015 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 5066

Query: 2188 QRLKAEATEAARQRSQVEEELFSVR 2212
            Q++   A E  R+ +   + L  +R
Sbjct: 5067 QQVWLLALERRRKLNDALDRLEELR 5091



 Score = 69.3 bits (168), Expect = 8e-11
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1047
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 4218 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 4270

Query: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1103
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 4271 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4327

Query: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4328 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4378

Query: 1164 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1222
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 4379 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4436

Query: 1223 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1263
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 4437 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4496

Query: 1264 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1323
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 4497 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4550

Query: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 4551 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4599

Query: 1384 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1439
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 4600 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4659

Query: 1440 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1495
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 4660 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4719

Query: 1496 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 4720 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4775

Query: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 4776 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4818

Query: 1614 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 4819 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4877

Query: 1670 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 4878 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4937

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1781
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 4938 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4997

Query: 1782 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1831
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 4998 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 5057

Query: 1832 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1870
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 5058 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 5117

Query: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1929
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 5118 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 5176

Query: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 5177 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 5213



 Score = 40.0 bits (92), Expect = 0.053
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 1038 EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 1096

Query: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 1097 DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 1136

Query: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 1137 AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 1195

Query: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 1196 CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 1254

Query: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 1255 LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 1314

Query: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 1315 KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1365

Query: 2499 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 1366 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1411

Query: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 1412 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1471

Query: 2616 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2645
            ++ +        +++  ++ LQ   +  A+
Sbjct: 1472 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1501



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 342  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 401
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4593 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4645

Query: 402  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 461
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4646 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4691

Query: 462  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 513
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4692 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4749

Query: 514  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 573
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4750 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4804

Query: 574  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 619
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4805 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4860

Query: 620  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 666
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 4861 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4909



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 4435 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 5393 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5443



 Score = 32.7 bits (73), Expect = 8.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 483  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 535
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4601 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4660

Query: 536  HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 590
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4661 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4720

Query: 591  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 642
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4721 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4777

Query: 643  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 702
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4778 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4837

Query: 703  FQFFSDVREA 712
             + F  V  A
Sbjct: 4838 AEEFHSVVHA 4847


>gi|34577049 dystonin isoform 1eA precursor [Homo sapiens]
          Length = 5171

 Score =  861 bits (2224), Expect = 0.0
 Identities = 630/2271 (27%), Positives = 1153/2271 (50%), Gaps = 198/2271 (8%)

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167

Query: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEIRV 1434
                            ++  ++++++ L++S         +Q + ++ S  +++EE+I V
Sbjct: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKI-V 1226

Query: 1435 VRLQLEATERQRGGAE----------GELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1484
               Q E  E+ +G  +          G  +A        E +K Q+++  E L++ +Q  
Sbjct: 1227 AERQQEYKEKLQGICDLLTQTENRLIGHQEAFMIGDGTVELKKYQSKQ--EELQKDMQGS 1284

Query: 1485 SQRKRQAEVELASRVKAEAEAAREKQRAL--QALEELRLQAEEAERRLRQAEVERARQVQ 1542
            +Q   +      + +K   E   ++ +AL  Q L E +++ E+   +  Q++ E  + V 
Sbjct: 1285 AQALAEVVKNTENFLKENGEKLSQEDKALIEQKLNEAKIKCEQLNLKAEQSKKELDKVVT 1344

Query: 1543 VAL--ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEA 1598
             A+  ET + +A  +L+  +         L    ++   A  + ++  E+     Q+ + 
Sbjct: 1345 TAIKEETEKVAAVKQLEESKTKIENLLDWLSNVDKDSERAGTKHKQVIEQNGTHFQEGDG 1404

Query: 1599 ERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEK----------QKEEAE 1648
            + A  E E E+    L+ +   ++    E + QQ    +A+ EK            + A+
Sbjct: 1405 KSAIGE-EDEVNGNLLETDVDGQVGTTQENLNQQYQKVKAQHEKIISQHQAVIIATQSAQ 1463

Query: 1649 REARRRGK---AEEQAVRQRELAEQELEKQRQLAEGTAQQRL--AAEQELIRLRAETEQG 1703
                ++G+    EE+   Q+ + E ++  +  LAE   + +L  + ++EL +  A+  + 
Sbjct: 1464 VLLEKQGQYLSPEEKEKLQKNMKELKVHYETALAESEKKMKLTHSLQEELEKFDADYTEF 1523

Query: 1704 EQQRQLLEEELARLQREA------AAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
            E   Q  E+EL  L+  A          ++++    ++   + ++  +  S  R  E ++
Sbjct: 1524 EHWLQQSEQELENLEAGADDINGLMTKLKRQKSFSEDVISHKGDLRYITISGNRVLEAAK 1583

Query: 1758 STSEKSKQRLEAEAGR---FRELAEEAARLRALAEE----AKRQRQLAE-----EDAA-- 1803
            S S++   +++  A      R+L     R R+L  +        + L +     EDA+  
Sbjct: 1584 SCSKRDGGKVDTSATHREVQRKLDHATDRFRSLYSKCNVLGNNLKDLVDKYQHYEDASCG 1643

Query: 1804 ------RQRAEAERVLAEKLAAIGEATRLKTEAEIALK----EKEAENERLRRLAEDEAF 1853
                     A A + L+E +A   +  + + E   AL+     ++   E+L++ AE    
Sbjct: 1644 LLAGLQACEATASKHLSEPIAVDPKNLQRQLEETKALQGQISSQQVAVEKLKKTAEVLLD 1703

Query: 1854 QRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVE---EEILALKA 1910
             R  L       +  +++ + +    S S  ER + L + TL +   V+   +E+L    
Sbjct: 1704 ARGSLLPAKNDIQKTLDDIVGRYEDLSKSVNERNEKL-QITLTRSLSVQDGLDEMLDWMG 1762

Query: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAE----- 1965
            + E +   + ++ L    ++      +  ++     A RQ  + A  E+ ++  E     
Sbjct: 1763 NVESSLKEQGQVPLNSTALQDIISKNIMLEQDI---AGRQSSINAMNEKVKKFMETTDPS 1819

Query: 1966 -----ERVQKSLAAE-EEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQE 2019
                 +   K L+A   EA+ + K  L ++E LK KVE    L E+ +     + Q   E
Sbjct: 1820 TASSLQAKMKDLSARFSEASHKHKETLAKMEELKTKVELFENLSEKLQTFLETKTQALTE 1879

Query: 2020 AAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-QA 2078
                     E      + Q  QE      + +  L+ L    +        +++A V + 
Sbjct: 1880 VDVPGKDVTE------LSQYMQESTSEFLEHKKHLEVLHSLLKEISSHGLPSDKALVLEK 1933

Query: 2079 EREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK 2138
                ++  +++E+  + K+ A    Q +  A     K  K   +E  ++    Q +   +
Sbjct: 1934 TNNLSKKFKEMEDTIKEKKEAVTSCQEQLDAFQVLVKSLKSWIKETTKKVPIVQPSFGAE 1993

Query: 2139 QAADAEMEKHKKFAEQTLRQKAQVEQ----ELTTLRLQLEETDHQKNL--LDEELQRLKA 2192
                + +E  KK  E+   +  ++++     ++   L    T   K +  +      L  
Sbjct: 1994 DLGKS-LEDTKKLQEKWSLKTPEIQKVNNSGISLCNLISAVTTPAKAIAAVKSGGAVLNG 2052

Query: 2193 EATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKD---NTQ----RFLQ 2245
            E T    +     + L S++  M ++S        E+  L+L+DK    NT+    +  Q
Sbjct: 2053 EGTATNTEEFWANKGLTSIKKDMTDISH-----GYEDLGLLLKDKIAELNTKLSKLQKAQ 2107

Query: 2246 EEAEKMKQVAEEAARLSVAAQEA-ARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLK 2304
            EE+  M Q  ++  + +   Q+  A     A +   +Q    E  LK+ +  VQE   LK
Sbjct: 2108 EESSAMMQWLQKMNKTATKWQQTPAPTDTEAVKTQVEQNKSFEAELKQNVNKVQE---LK 2164

Query: 2305 AE-AELLQQQKELAQ---------------EQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
             +  ELL++  +  +               ++  +L  D++Q  ++ +     FQ T+EA
Sbjct: 2165 DKLTELLEENPDTPEAPRWKQMLTEIDSKWQELNQLTIDRQQKLEESSNNLTQFQ-TVEA 2223

Query: 2349 ERQRQL------------------EMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEE 2390
            + ++ L                   ++ + +++++ + E +  + + E+     +     
Sbjct: 2224 QLKQWLVEKELMVSVLGPLSIDPNMLNTQRQQVQILLQEFATRKPQYEQLTAAGQGILSR 2283

Query: 2391 IGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQ-------- 2442
             GE      +  ++   + Q  +    Q     + + +AI +  + +  L+         
Sbjct: 2284 PGEDPSLRGIVKEQLAAVTQKWDSLTGQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDL 2343

Query: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEV 2502
            + KL    +         Q L+  Q ++Q    EK  +   +   E     L  L ++E 
Sbjct: 2344 DNKLSSSLAVSTHPDAMNQQLETAQKMKQEIQQEKKQIKVAQALCED----LSALVKEEY 2399

Query: 2503 AKAQQLREEQ--QRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQ 2560
             KA+  R+ +   +  + +EQ+ +  V  ++ A    H+ ++  R  Q  L   ++++ +
Sbjct: 2400 LKAELSRQLEGILKSFKDVEQKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNK 2459

Query: 2561 QEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDAL 2611
               + A        +L +LE   +     S+ +TA      KT+  G + L
Sbjct: 2460 SHPISA--------KLDVLESLIKDHKDFSKTLTAQSHMYEKTIAEGENLL 2502



 Score =  111 bits (277), Expect = 2e-23
 Identities = 346/1862 (18%), Positives = 719/1862 (38%), Gaps = 282/1862 (15%)

Query: 937  GSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARE 996
            G  S     + Q++ +  Q +S  +    +L D+  +L +    + H   +    E A++
Sbjct: 2310 GQLSDRCDWIDQAIVKSTQYQSLLRSLSDKLSDLDNKLSSSLAVSTHPDAMNQQLETAQK 2369

Query: 997  CAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR 1056
              Q I +Q+K Q +V           A  E + AL +       L  +LE  L   + V 
Sbjct: 2370 MKQEI-QQEKKQIKVA---------QALCEDLSALVKEEYLKAELSRQLEGILKSFKDVE 2419

Query: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ----AVPATLPELEAT----KA 1108
              +  +++ L++        Q      +A  +  KE Q     + A L  LE+     K 
Sbjct: 2420 QKAENHVQHLQSACASSHQFQQMSRDFQAWLDTKKEEQNKSHPISAKLDVLESLIKDHKD 2479

Query: 1109 SLKKLRAQAEAQQPTF---DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
              K L AQ+   + T    + L  + +G+++   +LQ                +  +   
Sbjct: 2480 FSKTLTAQSHMYEKTIAEGENLLLKTQGSEKAALQLQ----------------LNTIKTN 2523

Query: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
            W     Q   R+ +L++   +   Y+E  + L  W+   +   E+I+     D       
Sbjct: 2524 WDTFNKQVKERENKLKESLEKALKYKEQVETLWPWIDKCQNNLEEIKF--CLDPAEGENS 2581

Query: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAI---------------------------K 1258
            + + ++L +E+++H   VE     A   ++                             K
Sbjct: 2582 IAKLKSLQKEMDQHFGMVELLNNTANSLLSVCEIDKEVVTDENKSLIQKVDMVTEQLHSK 2641

Query: 1259 DYELQLVTYKAQLEPVASPAKKPKVQSGSESV-IQEYVDLRTHYSELTTLTSQYIKFISE 1317
             + L+ +T K +     S   K ++Q   E + I + +  + + ++  T+     K +  
Sbjct: 2642 KFCLENMTQKFKEFQEVSKESKRQLQCAKEQLDIHDSLGSQAYSNKYLTMLQTQQKSLQA 2701

Query: 1318 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ- 1376
               +++  +RLA+    E  +     +  L+ +  +A+ H+    Q + +   L+ ++Q 
Sbjct: 2702 LKHQVDLAKRLAQDLVVEASDSKGTSDVLLQVE-TIAQEHSTLSQQVDEKCSFLETKLQG 2760

Query: 1377 --------EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRI 1428
                     E+  +     D       +  + + L++  E  I+A  ++ EA   S    
Sbjct: 2761 IGHFQNTIREMFSQFAEFDDELDSMAPVGRDAETLQKQKET-IKAFLKKLEALMASNDNA 2819

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQAL-----------RARAEEAEAQKRQAQEEAERL 1477
             +  +++ L  E T     G + +L+AL           +AR E+ E   ++ +E   +L
Sbjct: 2820 NKTCKMM-LATEETSPDLVGIKRDLEALSKQCNKLLDRAQAREEQVEGTIKRLEEFYSKL 2878

Query: 1478 RR--------QVQDESQRKRQAEVELASR--------VKAEAEAAREKQR---------- 1511
            +         +  +ESQ     E E  ++         K E E  + KQ+          
Sbjct: 2879 KEFSILLQKAEEHEESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLI 2938

Query: 1512 -------ALQALEELRLQAEEAERRLRQAEVERARQVQVA-------------------- 1544
                   + Q LE          + L +   +RA Q+Q A                    
Sbjct: 2939 QSAAKSTSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVD 2998

Query: 1545 ---LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERA 1601
               L   Q+   AE +  +A   E+   L+R L +    V  ++ E E+ A     A++ 
Sbjct: 2999 TEELVANQKPPSAEFKVVKAQIQEQKL-LQRLLDDRKSTVEVIKREGEKIATTAEPADKV 3057

Query: 1602 REEAEREL--ERWQLKANEALRLRLQAE---EVAQQ--KSLAQ-----AEAEKQKEEAER 1649
            +   +  L   RW+   N+A     Q E    VAQQ  ++L          EK+    E 
Sbjct: 3058 KILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNCEP 3117

Query: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
               +  K EEQ  + + L +  +   + L +  +   +    +++  R + +  + +   
Sbjct: 3118 IGTQASKLEEQIAQHKALEDDIINHNKHLHQAVS---IGQSLKVLSSREDKDMVQSKLDF 3174

Query: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1769
             +     +Q ++ + ++  Q+     AK+  E EV L +     E     S+ S Q    
Sbjct: 3175 SQVWYIEIQEKSHSRSELLQQALCN-AKIFGEDEVELMN--WLNEVHDKLSKLSVQDYST 3231

Query: 1770 EAGRFRELAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAE-RVLAEKLAAI-- 1820
            E      L ++ + LR L E+   ++Q  ++      +  +Q    E  ++ +KL AI  
Sbjct: 3232 EG-----LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKA 3286

Query: 1821 --GEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI----EERLA 1874
               + T+L T+    L++      RL    E+      ++E +   ++  +    E   A
Sbjct: 3287 RYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQA 3346

Query: 1875 QLR-KASDSELERQKGLVEDTLRQRRQVEEEILALKA--SFEKAAAGKAEL--------- 1922
            Q+R K    E +  K L+ D+L +      E++  +A    EK  A   E          
Sbjct: 3347 QMRPKELKKEAKNNKALL-DSLNEVSSALLELVPWRAREGLEKMVAEDNERYRLVSDTIT 3405

Query: 1923 ----ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE---ERRRREAEERVQKSLAAE 1975
                E++   +RS   D     E + +    ++ ++  +   E+ +  A+ +VQK+   E
Sbjct: 3406 QKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTME 3465

Query: 1976 EEAARQRKAALEEVERLKAKV------EEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2029
                 + K  ++++ +   K+      EE + ++++ ++       + Q  +++ LQ  E
Sbjct: 3466 ---ILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQL-E 3521

Query: 2030 KAHAFAVQ--QKEQELQQTLQQEQSVLDQLRG---EAEAARRAAEEAEEARVQAEREAAQ 2084
            +A +   Q  +  +EL   L + QS++ QL     E E  R+  EE  + R         
Sbjct: 3522 RAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPH 3581

Query: 2085 SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQK----QA 2140
              +  +   +L + +  +  +  +   AA+ L  + +++  +RA A   A+ Q       
Sbjct: 3582 IDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDK 3641

Query: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDH---QKNLLDEELQRLKAEATEA 2197
             D  +E  ++  E+ LRQ   +  E+  ++ Q+ E  +       L    + LK    E 
Sbjct: 3642 IDQILESLERIVER-LRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEM 3700

Query: 2198 ARQRSQVEEELFSVRVQMEELSKLKARIEA-ENRALILRDKDNTQRFLQEEAEKMKQVAE 2256
              +    ++++ +  VQ     KL   +   EN   ++ +++     + E AEK     +
Sbjct: 3701 IARSGGTDKDISAKAVQ----DKLDQMVFIWENIHTLVEEREAKLLDVMELAEKF--WCD 3754

Query: 2257 EAARLSVAAQEAARLRQL----AEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELL 2310
              + +         +R L     +  + +Q+  A + ++E++  +QE     +   +EL+
Sbjct: 3755 HMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQEELDIVINLGSELI 3814

Query: 2311 ----QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR 2366
                +  K + ++    L    + + +   +     +  ++A  Q Q  + A  + + + 
Sbjct: 3815 AACGEPDKPIVKKSIDELNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQAVFDWVDIA 3874

Query: 2367 VAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL 2426
              +++ + +    D +  ++Q EE+  K  ++E   Q         +I+ ++ +H AE L
Sbjct: 3875 GGKLA-SMSPIGTDLETVKQQIEEL--KQFKSEAYQQ---------QIEMERLNHQAELL 3922

Query: 2427 REAIAELEREKEKLQ---QEAKLLQLKSEEMQTVQQEQLLQETQALQQ---------SFL 2474
             + + E E +K  +Q    E KL+    EE    +Q +L     AL Q         ++L
Sbjct: 3923 LKKVTE-ESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWL 3981

Query: 2475 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR---LVASM- 2530
            +  + LL  ++ +  +   +E     E+AK   L+ +    Q  +E   +    L+ S  
Sbjct: 3982 THTEGLLSEQKPVGGDPKAIE----IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSA 4037

Query: 2531 -EEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE---NQRLREQLQLLEEQHRAA 2586
             EEA   Q++ E   +R Q  L++ EQ+++Q +  L +    +  + +  Q L +  R  
Sbjct: 4038 GEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTERHL 4097

Query: 2587 LA 2588
            LA
Sbjct: 4098 LA 4099



 Score = 94.0 bits (232), Expect = 3e-18
 Identities = 353/1847 (19%), Positives = 705/1847 (38%), Gaps = 283/1847 (15%)

Query: 928  DRLMAEREYGSCSHHYQQLLQSLEQGAQEES------RCQRCISELKDIRLQLEACETRT 981
            D +  +R+  + S    +LL   +  A+EE       R +   S+LK+  + L+  E   
Sbjct: 2835 DLVGIKRDLEALSKQCNKLLDRAQ--AREEQVEGTIKRLEEFYSKLKEFSILLQKAEEHE 2892

Query: 982  VHRLRLPLDKEPARECA--------QRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE 1033
              +  + ++ E   +          + I   Q  Q +V  LG+G+ + +A+         
Sbjct: 2893 ESQGPVGMETETINQQLNMFKVFQKEEIEPLQGKQQDVNWLGQGLIQSAAK--------- 2943

Query: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEA 1093
             S +   L  +L+    + + +    A    +L+   L     Q A E L +     +E 
Sbjct: 2944 -STSTQGLEHDLDDVNARWKTLNKKVAQRAAQLQEALLHCGRFQDALESLLSWMVDTEEL 3002

Query: 1094 QAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVE 1153
             A        +   A  K ++AQ + +Q     L D+ +   EV +R  ++        +
Sbjct: 3003 VA------NQKPPSAEFKVVKAQIQ-EQKLLQRLLDDRKSTVEVIKREGEKIATTAEPAD 3055

Query: 1154 RWR--ERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQI 1211
            + +  ++++ L  RW+A+L + + R R+LE +    + + E+ +PL  WL    +R    
Sbjct: 3056 KVKILKQLSLLDSRWEALLNKAETRNRQLEGISVVAQQFHETLEPLNEWLTTIEKRLVNC 3115

Query: 1212 QAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL 1271
            + +    S+ + EQ+ Q +AL ++I  H + + +     +         +  +V  K   
Sbjct: 3116 EPIGTQASK-LEEQIAQHKALEDDIINHNKHLHQAVSIGQSLKVLSSREDKDMVQSKLDF 3174

Query: 1272 EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE- 1330
              V     + K  S SE + Q   + +  + E       ++  + + L ++  ++   E 
Sbjct: 3175 SQVWYIEIQEKSHSRSELLQQALCNAKI-FGEDEVELMNWLNEVHDKLSKLSVQDYSTEG 3233

Query: 1331 --QQRAEERE-------RLAEVEAALEKQRQLAEAHA-------QAKAQAEREAKELQQR 1374
              +Q++E R        R   V+ AL    +L +          Q K +A +   +   +
Sbjct: 3234 LWKQQSELRVLQEDILLRKQNVDQALLNGLELLKQTTGDEVLIIQDKLEAIKARYKDITK 3293

Query: 1375 MQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQA------KARQAEAAERSRLRI 1428
            +  +V +  E A+   ++  S  EEL       E E+ +      K  +A  A+     +
Sbjct: 3294 LSTDVAKTLEQALQLARRLHSTHEELCTWLDKVEVELLSYETQVLKGEEASQAQMRPKEL 3353

Query: 1429 EEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1488
            ++E +  +  L++   +   A  EL   RAR    E  ++   E+ ER R      +Q+ 
Sbjct: 3354 KKEAKNNKALLDSL-NEVSSALLELVPWRAR----EGLEKMVAEDNERYRLVSDTITQKV 3408

Query: 1489 RQAEV------ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-----QAEVER 1537
             + +       +      AE     E ++ L +L ++RL+ ++   +L+       E+ R
Sbjct: 3409 EEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIRLEQDQTSAQLQVQKTFTMEILR 3468

Query: 1538 ARQ-----VQVALETAQRSAEAELQSKRASF--------------AEKTAQLERS----- 1573
             +      V+   +     +E E QS +                 +E+  QLER+     
Sbjct: 3469 HKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLKNYDTICQINSERYLQLERAQSLVN 3528

Query: 1574 ------------LQEEHVAVAQLRE---EAERRAQQQAEAERARE---EAERELERWQLK 1615
                        L E    ++QL     E E   QQQ E  + RE   E +  +++    
Sbjct: 3529 QFWETYEELWPWLTETQSIISQLPAPALEYETLRQQQEEHRQLRELIAEHKPHIDKMNKT 3588

Query: 1616 ANEALRLRLQAEEVAQQKSLAQAEAEKQ-KEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
              + L L        Q+K +A      Q KE+ ++ A    +A  Q+ +  +  +Q LE 
Sbjct: 3589 GPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKKRAVALDEAISQSTQFHDKIDQILES 3648

Query: 1675 QRQLAEGTAQ-QRLAAEQELIRLRAETEQG-----EQQRQLLEEELARLQREAAAATQKR 1728
              ++ E   Q   ++AE E I+ +    +      E+ + L E    R +   A +    
Sbjct: 3649 LERIVERLRQPPSISAEVEKIKEQISENKNVSVDMEKLQPLYETLKQRGEEMIARSGGTD 3708

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE-----AAR 1783
            +++ A+  + + +  V +        E R          EA+     ELAE+      + 
Sbjct: 3709 KDISAKAVQDKLDQMVFIWENIHTLVEER----------EAKLLDVMELAEKFWCDHMSL 3758

Query: 1784 LRALAEEAKRQRQL----AEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
            +  + +     R L     +    +Q+ EA   + E++  + E      E +I +     
Sbjct: 3759 IVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIREEIDGLQE------ELDIVI---NL 3809

Query: 1840 ENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQR 1898
             +E +    E D+   ++ ++E        +      L KA    +++    +E+ ++  
Sbjct: 3810 GSELIAACGEPDKPIVKKSIDE--------LNSAWDSLNKAWKDRIDK----LEEAMQAA 3857

Query: 1899 RQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEE 1958
             Q ++ + A+   +   A GK      +G      +  +   +Q + EA +Q+    E E
Sbjct: 3858 VQYQDGLQAV-FDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQ---IEME 3913

Query: 1959 RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQ 2018
            R   +AE  ++K    EE      +  L E++ +   +EE    R+   + +   L   Q
Sbjct: 3914 RLNHQAELLLKK--VTEESDKHTVQDPLMELKLIWDSLEERIINRQHKLEGALLALGQFQ 3971

Query: 2019 EAAQKRLQAEEKAHAFAVQQK---------EQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
             A  + L           +QK         E EL +    +  VL   +   EA  +A  
Sbjct: 3972 HALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAH-QSTVEAVNKAGN 4030

Query: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
            +  E+   A  EA+  + ++E   +  Q+  E+ +            RK+    A R+A+
Sbjct: 4031 DLIES--SAGEEASNLQNKLEVLNQRWQNVLEKTEQ-----------RKQQLDGALRQAK 4077

Query: 2130 AEQAALRQKQAADAEMEKHKKFAE------QTLRQKAQVEQELTTLRLQLEETDHQKNLL 2183
                 +   Q    + E+H   ++      +T +++  V  E+       EET   K+L+
Sbjct: 4078 GFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEET--YKSLM 4135

Query: 2184 DEELQRL----KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDN 2239
             +  Q L    K+  T   +  + ++E+  SV  ++ E    K ++E E   L +   ++
Sbjct: 4136 QKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE---RKTKLE-EALNLAMEFHNS 4191

Query: 2240 TQRFLQ--EEAEKMKQVAEEAAR-LSVAAQEAARLRQLAEEDLAQQRALAE--------K 2288
             Q F+    +AE+   VA   +  L     +    +  A E  + +  + E        K
Sbjct: 4192 LQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEVNSHREQIIELDKTGTHLK 4251

Query: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
               +K   V     L +     ++  +   E+ R L +D  + A+Q  E        LE 
Sbjct: 4252 YFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSL-DDARKRAKQFHEAWSKLMEWLEE 4310

Query: 2349 ERQ---RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEK 2405
              +    +LE++ + +++K ++A+         ++ Q+       + +  +RT  + +EK
Sbjct: 4311 SEKSLDSELEIANDPDKIKTQLAQ--------HKEFQKSLGAKHSVYDTTNRTGRSLKEK 4362

Query: 2406 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL-- 2463
             +L             D  +L + ++EL  + + +         KS E Q   +E LL  
Sbjct: 4363 TSLAD-----------DNLKLDDMLSELRDKWDTICG-------KSVERQNKLEEALLFS 4404

Query: 2464 -QETQALQQ--SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQME 2520
             Q T ALQ    +L   +  L  ++ +  +   +  L  +  A  ++L +     Q    
Sbjct: 4405 GQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKR 4464

Query: 2521 QERQRLVASMEEARRRQHEAEEGVRRKQ-------EELQQLEQQRRQQEEL--------- 2564
              R+ +  S +++   + + +E   R +        +  +LE   RQ EE          
Sbjct: 4465 SARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLE 4524

Query: 2565 -LAEENQRLR---------EQLQLLEEQHRAALAHSEEVTASQVAAT 2601
             LAE  Q LR         + L+ L +QH+  +   EE  A    AT
Sbjct: 4525 WLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKAT 4571



 Score = 85.1 bits (209), Expect = 1e-15
 Identities = 295/1541 (19%), Positives = 608/1541 (39%), Gaps = 226/1541 (14%)

Query: 1104 EATKASL--KKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRER--- 1158
            EA++A +  K+L+ +A+  +   D+L        EV   L        +E+  WR R   
Sbjct: 3342 EASQAQMRPKELKKEAKNNKALLDSLN-------EVSSAL--------LELVPWRAREGL 3386

Query: 1159 ---VAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
               VA+  ER++ V      +  E++    + + + ++AD   +W+ +  ++   +  + 
Sbjct: 3387 EKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGDIR 3446

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVA 1275
            L   Q    QL+ ++    EI RH + +++  +   + + A  + E Q  + K +L+ V 
Sbjct: 3447 LEQDQT-SAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQ--SMKKKLDKVL 3503

Query: 1276 SP------------AKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIK--FISETLRR 1321
                           +  + QS      + Y +L    +E  ++ SQ        ETLR+
Sbjct: 3504 KNYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQ 3563

Query: 1322 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVR 1381
             +EE R   +  AE +  + ++     +  +L+     +  +    A  L  +++E+V +
Sbjct: 3564 QQEEHRQLRELIAEHKPHIDKMNKTGPQLLELSPGEGFSIQEKYVAADTLYSQIKEDVKK 3623

Query: 1382 REEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIR-------- 1433
            R  A  +A  Q     +++ Q+ +S E  ++ + RQ  +      +I+E+I         
Sbjct: 3624 RAVALDEAISQSTQFHDKIDQILESLERIVE-RLRQPPSISAEVEKIKEQISENKNVSVD 3682

Query: 1434 VVRLQ-LEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR------RQVQDESQ 1486
            + +LQ L  T +QRG    E    R+   + +   +  Q++ +++         + +E +
Sbjct: 3683 MEKLQPLYETLKQRG----EEMIARSGGTDKDISAKAVQDKLDQMVFIWENIHTLVEERE 3738

Query: 1487 RKRQAEVELASRVKAEAEAA----REKQRALQALEELRL------QAEEAERRLRQAEVE 1536
             K    +ELA +   +  +     ++ Q  ++ LE+  +      Q +EA   +R+ E++
Sbjct: 3739 AKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLEDPGIDPSVVKQQQEAAETIRE-EID 3797

Query: 1537 RARQ-----VQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERR 1591
              ++     + +  E      E +    + S  E  +  + SL +         EEA + 
Sbjct: 3798 GLQEELDIVINLGSELIAACGEPDKPIVKKSIDELNSAWD-SLNKAWKDRIDKLEEAMQA 3856

Query: 1592 AQQQAEAERAREE----AERELERWQLKANEALRLRLQAEEVAQQKSLA---QAEAEKQK 1644
            A Q  +  +A  +    A  +L        +   ++ Q EE+ Q KS A   Q E E+  
Sbjct: 3857 AVQYQDGLQAVFDWVDIAGGKLASMSPIGTDLETVKQQIEELKQFKSEAYQQQIEMERLN 3916

Query: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
             +AE   ++  +  ++   Q  L E +L     L E    ++   E  L+ L        
Sbjct: 3917 HQAELLLKKVTEESDKHTVQDPLMELKLIWD-SLEERIINRQHKLEGALLALG------- 3968

Query: 1705 QQRQLLEEELARLQREAAAATQKR------QELEAELAKVRAEMEVLLASKARAEEESRS 1758
            Q +  L+E LA L       ++++      + +E ELAK       +LA ++  E  +++
Sbjct: 3969 QFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIEIELAKHHVLQNDVLAHQSTVEAVNKA 4028

Query: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
             ++     +E+ AG      EEA+ L+   E   ++ Q   E   +++ + +  L +   
Sbjct: 4029 GNDL----IESSAG------EEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQAKG 4078

Query: 1819 AIGEATRLK-----TEAEIALKEK-----EAENERLR-RLAEDEAFQRRRLEEQAAQHKA 1867
              GE   L+     TE  +   +      E   E+L   +    AF+ +    ++   K 
Sbjct: 4079 FHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNVHMEVCAAFEAKEETYKSLMQKG 4138

Query: 1868 DIEERLAQLRKASDSELERQKG-------LVEDTLRQRRQVEEEILALKASFEKAAAG-- 1918
              ++ LA+  K++++ +++           VE  L +R+   EE L L   F  +     
Sbjct: 4139 --QQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKTKLEEALNLAMEFHNSLQDFI 4196

Query: 1919 ----KAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAA 1974
                +AE  L +    S   DT+       L    + ++ A E    RE    + K+   
Sbjct: 4197 NWLTQAEQTLNVASRPSLILDTV-------LFQIDEHKVFANEVNSHREQIIELDKTGTH 4249

Query: 1975 EEEAARQRKAAL-------------EEVERLKAKVEEARRLRERAEQ--ESARQLQLAQE 2019
             +  ++++   L             + V+RL  +       R+RA+Q  E+  +L    E
Sbjct: 4250 LKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLE 4309

Query: 2020 AAQKRLQAE-------EKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
             ++K L +E       +K      Q KE   Q++L  + SV D       + +     A+
Sbjct: 4310 ESEKSLDSELEIANDPDKIKTQLAQHKE--FQKSLGAKHSVYDTTNRTGRSLKEKTSLAD 4367

Query: 2073 EARVQAEREAAQSR--------RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEA 2124
            +  ++ +   ++ R        + VE   +L+++     Q     QA  + L +   Q A
Sbjct: 4368 D-NLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEPQLA 4426

Query: 2125 ARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLD 2184
                  +Q            ++ HK F ++  ++ + V+    + R  +E +    + + 
Sbjct: 4427 E-----DQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSRDDSSWVK 4481

Query: 2185 EELQRLKAEATEAARQRSQVEEELFSVRVQMEELSK-----LKARIEAEN----RALILR 2235
             ++Q L              +  L +   Q EE        L+   EAE       ++  
Sbjct: 4482 VQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHALLEWLAEAEQTLRFHGVLPD 4541

Query: 2236 DKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEED--------LAQQRALAE 2287
            D+D  +  + +  E MK++ E+ A L+ A      +  +   D        +   RA  E
Sbjct: 4542 DEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFE 4601

Query: 2288 KML---KEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGF- 2342
            ++L   K+  Q +  A   L A+ ELL+      Q     L +  +++  Q  EE +   
Sbjct: 4602 EVLAWAKQHQQRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALI 4661

Query: 2343 ---QRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARA----EEDAQRFRKQAEEIGEKL 2395
               Q  +E   ++Q ++    +  K R A+ S  Q+      +  A R R  A  +    
Sbjct: 4662 AEHQTFMEEMTRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSG 4721

Query: 2396 HRTELATQ--------EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
             +T++ T+         K   V  L ++R++      +L +A+  LE  +E    +  + 
Sbjct: 4722 SQTQIETKNPRVNLLVSKWQQVWLLALERRR------KLNDALDRLEELREFANFDFDIW 4775

Query: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
            + K       ++ +++   + + +    ++D  + R+ FI+
Sbjct: 4776 RKKYMRWMNHKKSRVMDFFRRIDK----DQDGKITRQEFID 4812



 Score = 78.6 bits (192), Expect = 1e-13
 Identities = 352/1885 (18%), Positives = 731/1885 (38%), Gaps = 251/1885 (13%)

Query: 490  QRRPELEDSTLRY------LQDLLAWVEENQHRVDGAEW-GVDLPSVEAQLGSHRGLHQS 542
            QR  +L+++ L        L+ LL+W+ + +  V   +    +   V+AQ+   + L + 
Sbjct: 2970 QRAAQLQEALLHCGRFQDALESLLSWMVDTEELVANQKPPSAEFKVVKAQIQEQKLLQRL 3029

Query: 543  IEEFRAKIERARSDEGQLS----PATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHS 598
            +++ ++ +E  + +  +++    PA +      L  LD ++  LLN ++ R R LE + S
Sbjct: 3030 LDDRKSTVEVIKREGEKIATTAEPADKVKILKQLSLLDSRWEALLNKAETRNRQLEGI-S 3088

Query: 599  FVAAATKELM-----WLNEKEEEEVGFD-WSDRNTNMTAKKESYSALMRELELKEKKIKE 652
             VA    E +     WL   E+  V  +    + + +  +   + AL  ++    K + +
Sbjct: 3089 VVAQQFHETLEPLNEWLTTIEKRLVNCEPIGTQASKLEEQIAQHKALEDDIINHNKHLHQ 3148

Query: 653  LQNAGDRLLREDHPARPTVESFQAALQTQWSW-------------MLQLCCC-------- 691
              + G  L  +   +R   +  Q+ L     W             +LQ   C        
Sbjct: 3149 AVSIGQSL--KVLSSREDKDMVQSKLDFSQVWYIEIQEKSHSRSELLQQALCNAKIFGED 3206

Query: 692  --------IEAHLKENAAYFQFFS--DVREAEGQLQKLQE-ALRRKYSCDRSATVTRLED 740
                     E H K +    Q +S   + + + +L+ LQE  L RK + D+ A +  LE 
Sbjct: 3207 EVELMNWLNEVHDKLSKLSVQDYSTEGLWKQQSELRVLQEDILLRKQNVDQ-ALLNGLEL 3265

Query: 741  LLQDAQDE----KEQLNEYKGHL-------SGLAKRAKAVVQLKPR-HPAHPMRGRLPLL 788
            L Q   DE    +++L   K          + +AK  +  +QL  R H  H         
Sbjct: 3266 LKQTTGDEVLIIQDKLEAIKARYKDITKLSTDVAKTLEQALQLARRLHSTHEELCTWLDK 3325

Query: 789  AVCDYKQVEVTVHKGDECQLVG------PAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQE 842
               +    E  V KG+E             +  + K L  S +E +  ++  LVP   +E
Sbjct: 3326 VEVELLSYETQVLKGEEASQAQMRPKELKKEAKNNKALLDSLNEVS-SALLELVPWRARE 3384

Query: 843  AQEAVTRLEAQHQALV--TLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKP--- 897
              E +   + +   LV  T+  ++     ++L  Q   +      SW   T + L     
Sbjct: 3385 GLEKMVAEDNERYRLVSDTITQKVEEIDAAILRSQQFDQAADAELSWITETEKKLMSLGD 3444

Query: 898  --EEQRQALHSLE---------LHYQAFLRDSQDAG-----GFGPEDRLMAEREYGSCSH 941
               EQ Q    L+         L ++  + D   +G         E++   +++      
Sbjct: 3445 IRLEQDQTSAQLQVQKTFTMEILRHKDIIDDLVKSGHKIMTACSEEEKQSMKKKLDKVLK 3504

Query: 942  HYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRT---VHRLRLPL--------D 990
            +Y  + Q   +   +  R Q  +++  +   +L    T T   + +L  P          
Sbjct: 3505 NYDTICQINSERYLQLERAQSLVNQFWETYEELWPWLTETQSIISQLPAPALEYETLRQQ 3564

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLG 1050
            +E  R+  + IAE +    ++   G  +  LS    +  ++ E   AA TL S+++  + 
Sbjct: 3565 QEEHRQLRELIAEHKPHIDKMNKTGPQLLELS--PGEGFSIQEKYVAADTLYSQIKEDVK 3622

Query: 1051 K----LEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEAT 1106
            K    L++  S S  + +K+  I           E L    E+L++  ++ A + +++  
Sbjct: 3623 KRAVALDEAISQSTQFHDKIDQIL----------ESLERIVERLRQPPSISAEVEKIKEQ 3672

Query: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHG--ERDVEVERWRERVAQLLE 1164
             +  K +    E  QP ++ L+         GE +  R G  ++D+  +  ++++ Q++ 
Sbjct: 3673 ISENKNVSVDMEKLQPLYETLKQR-------GEEMIARSGGTDKDISAKAVQDKLDQMVF 3725

Query: 1165 RWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVRE 1224
             W+ +    + R+ +L  +      +      L   ++D +     ++  P  D   V++
Sbjct: 3726 IWENIHTLVEEREAKLLDVMELAEKFWCDHMSLIVTIKDTQDFIRDLED-PGIDPSVVKQ 3784

Query: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
            Q    + + EEI+   E+++       + I A  + +  +V  K  ++         ++ 
Sbjct: 3785 QQEAAETIREEIDGLQEELDIVINLGSELIAACGEPDKPIV--KKSID---------ELN 3833

Query: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
            S  +S+ + + D      E      QY     + L+ + +   +A  + A     ++ + 
Sbjct: 3834 SAWDSLNKAWKDRIDKLEEAMQAAVQY----QDGLQAVFDWVDIAGGKLAS----MSPIG 3885

Query: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
              LE  +Q  E   Q K++A ++  E+++   Q E++ ++   V  +  K ++Q+ L +L
Sbjct: 3886 TDLETVKQQIEELKQFKSEAYQQQIEMERLNHQAELLLKK---VTEESDKHTVQDPLMEL 3942

Query: 1404 R---QSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATE------RQRGGAEGELQ 1454
            +    S E  I  +  + E A  +  + +  +  +   L  TE      +  GG    ++
Sbjct: 3943 KLIWDSLEERIINRQHKLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAIE 4002

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREK-QRAL 1513
               A+    +      Q   E + +   D  +     E   AS ++ + E   ++ Q  L
Sbjct: 4003 IELAKHHVLQNDVLAHQSTVEAVNKAGNDLIESSAGEE---ASNLQNKLEVLNQRWQNVL 4059

Query: 1514 QALEELRLQAEEAERRLR--QAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLE 1571
            +  E+ + Q + A R+ +    E+E    +Q  L   +R     L SK      +TA+ +
Sbjct: 4060 EKTEQRKQQLDGALRQAKGFHGEIE---DLQQWLTDTERHL---LASKPLGGLPETAKEQ 4113

Query: 1572 RSLQEEHVAVAQLREEAERRAQQQAEAERAR--------------------EEAERELER 1611
             ++  E  A  + +EE  +   Q+ +   AR                    E  E +L  
Sbjct: 4114 LNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNE 4173

Query: 1612 WQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQE 1671
             + K  EAL L ++     Q       +AE+    A R +        Q    +  A + 
Sbjct: 4174 RKTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKVFANEV 4233

Query: 1672 LEKQRQLAE----GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQK 1727
               + Q+ E    GT  +  + +Q+++ ++      + + + + + L    R    A ++
Sbjct: 4234 NSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRWEKVVQRLVERGRSLDDARKR 4293

Query: 1728 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL 1787
             ++     +K+   ME L  S+   + E    ++  K  ++ +  + +E  +      ++
Sbjct: 4294 AKQFHEAWSKL---MEWLEESEKSLDSELEIANDPDK--IKTQLAQHKEFQKSLGAKHSV 4348

Query: 1788 AEEAKRQ-RQLAEEDA-ARQRAEAERVLAEKL----AAIGEATRLKTEAEIALKEKEAEN 1841
             +   R  R L E+ + A    + + +L+E         G++   + + E AL       
Sbjct: 4349 YDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFT 4408

Query: 1842 ERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQ 1900
            + L+ L +     + +  E+Q      D+   L    KA   EL ++   V+   R  R+
Sbjct: 4409 DALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARE 4468

Query: 1901 VEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERR 1960
            +      ++ S + ++  K +++ EL   R      L   +Q  LEAA ++   AEE   
Sbjct: 4469 L------IEGSRDDSSWVKVQMQ-ELS-TRWETVCALSISKQTRLEAALRQ---AEE--- 4514

Query: 1961 RREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEA 2020
                   + + LA  E+  R      ++ + L+  +++ +   ++ E++ A +L  A   
Sbjct: 4515 FHSVVHALLEWLAEAEQTLRFHGVLPDDEDALRTLIDQHKEFMKKLEEKRA-ELNKATTM 4573

Query: 2021 AQKRLQ-------AEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEE 2073
                L           K     ++ + +E+    +Q Q    Q    A A   A +E  E
Sbjct: 4574 GDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ----QRLASALAGLIAKQELLE 4629

Query: 2074 ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL-RKEAEQEAA----RRA 2128
            A + A  + A++    ++ E + Q  EE     A+ Q   E++ RK+ + +      +R 
Sbjct: 4630 A-LLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEMTRKQPDVDKVTKTYKRR 4688

Query: 2129 QAEQAALRQK-QAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187
             A+ ++L+      D      K+F   +L             + Q+E  + + NLL  + 
Sbjct: 4689 AADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGS--------QTQIETKNPRVNLLVSKW 4740

Query: 2188 QRLKAEATEAARQRSQVEEELFSVR 2212
            Q++   A E  R+ +   + L  +R
Sbjct: 4741 QQVWLLALERRRKLNDALDRLEELR 4765



 Score = 69.3 bits (168), Expect = 8e-11
 Identities = 208/1057 (19%), Positives = 422/1057 (39%), Gaps = 142/1057 (13%)

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS---ELEL 1047
            K+   E  Q  +E  + Q E+E       RL+ +AE +L          T++    EL+L
Sbjct: 3892 KQQIEELKQFKSEAYQQQIEME-------RLNHQAELLLKKVTEESDKHTVQDPLMELKL 3944

Query: 1048 TLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAH----EEQLKEAQAVPATLPEL 1103
                LE+ R ++  +  KL+   L +   Q A + L A     E  L E + V      +
Sbjct: 3945 IWDSLEE-RIINRQH--KLEGALLALGQFQHALDELLAWLTHTEGLLSEQKPVGGDPKAI 4001

Query: 1104 EATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL 1163
            E   A    L+    A Q T +A+       +   + ++   GE   E    + ++  L 
Sbjct: 4002 EIELAKHHVLQNDVLAHQSTVEAVN------KAGNDLIESSAGE---EASNLQNKLEVLN 4052

Query: 1164 ERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLAD-SQAV 1222
            +RWQ VL +T+ R+++L+   RQ + +    + L  WL D  R    + + PL    +  
Sbjct: 4053 QRWQNVLEKTEQRKQQLDGALRQAKGFHGEIEDLQQWLTDTER--HLLASKPLGGLPETA 4110

Query: 1223 REQLR-----------QEQALLEEIERHGEKVEECQRFAK----QYINAIKD----YELQ 1263
            +EQL            +E+     +++  + +  C + A+    Q IN +K+     E +
Sbjct: 4111 KEQLNVHMEVCAAFEAKEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETK 4170

Query: 1264 LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRME 1323
            L   K +LE   + A +        + +Q++++  T   +   + S+    +   L +++
Sbjct: 4171 LNERKTKLEEALNLAME------FHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQID 4224

Query: 1324 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE 1383
            E +  A            EV +  E+  +L +     K  ++++   L + +   V  R 
Sbjct: 4225 EHKVFAN-----------EVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLLISVQSRW 4273

Query: 1384 EAAVDAQQQK-RSIQEELQQLRQSSEA--EIQAKARQAEAAERSRLRIEEEIRVVRLQL- 1439
            E  V    ++ RS+ +  ++ +Q  EA  ++     ++E +  S L I  +   ++ QL 
Sbjct: 4274 EKVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLA 4333

Query: 1440 EATERQRG-GAEGELQALRARAEEAEAQKRQAQEE---AERLRRQVQDESQRKRQAEVEL 1495
            +  E Q+  GA+  +     R   +  +K    ++    + +  +++D+        VE 
Sbjct: 4334 QHKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVER 4393

Query: 1496 ASRVKAEAEAAREKQRALQALEE--LRLQAEEAERRLRQAEVERARQVQVALETAQRSAE 1553
             ++++     + +   ALQAL +   R++ + AE +    +++    + + L    ++ +
Sbjct: 4394 QNKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDID----LVMNLIDNHKAFQ 4449

Query: 1554 AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ 1613
             EL  + +S       L+RS +E    +   R+++     Q  E             RW+
Sbjct: 4450 KELGKRTSS----VQALKRSARE---LIEGSRDDSSWVKVQMQELS----------TRWE 4492

Query: 1614 ----LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAE 1669
                L  ++  RL     +  +  S+  A  E    EAE+  R  G   +     R L +
Sbjct: 4493 TVCALSISKQTRLEAALRQAEEFHSVVHALLE-WLAEAEQTLRFHGVLPDDEDALRTLID 4551

Query: 1670 QELEKQRQLAEGTAQQRLAAEQ-ELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
            Q  E  ++L E  A+   A    + +      +     +  +    AR +   A A Q +
Sbjct: 4552 QHKEFMKKLEEKRAELNKATTMGDTVLAICHPDSITTIKHWITIIRARFEEVLAWAKQHQ 4611

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFREL-------AEEA 1781
            Q L + LA + A+ E+L A  A  +    + ++K K+ +  E    + L        EE 
Sbjct: 4612 QRLASALAGLIAKQELLEALLAWLQWAETTLTDKDKEVIPQEIEEVKALIAEHQTFMEEM 4671

Query: 1782 ARLRALAEE-AKRQRQLAEEDAARQ---------RAEAERVLAEKLAAIGEATRLKTEAE 1831
             R +   ++  K  ++ A + ++ Q         RA  +R  A  L   G  T+++T+  
Sbjct: 4672 TRKQPDVDKVTKTYKRRAADPSSLQSHIPVLDKGRAGRKRFPASSLYPSGSQTQIETKNP 4731

Query: 1832 --------------IALKEKEAENERLRRLAEDEAFQ-------RRRLEEQAAQHKADIE 1870
                          +AL+ +   N+ L RL E   F        R++        K+ + 
Sbjct: 4732 RVNLLVSKWQQVWLLALERRRKLNDALDRLEELREFANFDFDIWRKKYMRWMNHKKSRVM 4791

Query: 1871 ERLAQLRKASDSELERQKGLVEDTLRQRRQVEE-EILALKASFEKAAAGKAELELELGRI 1929
            +   ++ K  D ++ RQ+  ++  L  +      E+ A+   F++   G  +    +  +
Sbjct: 4792 DFFRRIDKDQDGKITRQE-FIDGILSSKFPTSRLEMSAVADIFDRDGDGYIDYYEFVAAL 4850

Query: 1930 RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEE 1966
              N +      +  ++E    RQ+A  +  +R + E+
Sbjct: 4851 HPNKDAYKPITDADKIEDEVTRQVAKCKCAKRFQVEQ 4887



 Score = 64.3 bits (155), Expect = 3e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 368 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 427
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 428 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153



 Score = 40.0 bits (92), Expect = 0.053
 Identities = 84/510 (16%), Positives = 207/510 (40%), Gaps = 52/510 (10%)

Query: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770

Query: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810

Query: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869

Query: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928

Query: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988

Query: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E       +++ EQ  A ++  +
Sbjct: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDEC------QKYAEQYSATVKD-Y 1039

Query: 2499 QDEVAKAQQLREEQQR---QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE 2555
            + +    + + + QQ+   ++++M+     ++    + R R                 L 
Sbjct: 1040 ELQTMTYRAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRY--------------TALV 1085

Query: 2556 QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPA 2615
                Q  +   +  +RL E+ + LEE+ +  +  ++E+       +KTL +   A   P 
Sbjct: 1086 TLMTQYIKFAGDSLKRLEEEEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPF 1145

Query: 2616 AEAEPEHSFDGLRRKVSAQRLQEAGILSAE 2645
            ++ +        +++  ++ LQ   +  A+
Sbjct: 1146 SKQKISSEEISTKKEQLSEALQTIQLFLAK 1175



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 74/349 (21%), Positives = 137/349 (39%), Gaps = 56/349 (16%)

Query: 342  LDVEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDV 401
            + V+  W K+   ++ER + L    +R +      +KL        E L +++  L S++
Sbjct: 4267 ISVQSRWEKVVQRLVERGRSLDDARKRAKQFHEAWSKLM-------EWLEESEKSLDSEL 4319

Query: 402  RLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVA 461
                         E+  D DK  + +     + Q     +H   +   R    L E+   
Sbjct: 4320 -------------EIANDPDKIKTQLAQ-HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSL 4365

Query: 462  IRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTL------RYLQDLLAWVE--EN 513
               + NL+L   ++    +   +  +SV+R+ +LE++ L        LQ L+ W+   E 
Sbjct: 4366 --ADDNLKLDDMLSELRDKWDTICGKSVERQNKLEEALLFSGQFTDALQALIDWLYRVEP 4423

Query: 514  QHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLG 573
            Q   D    G D+  V   + +H+   + + +  + ++  +    +L   +R    D   
Sbjct: 4424 QLAEDQPVHG-DIDLVMNLIDNHKAFQKELGKRTSSVQALKRSARELIEGSR----DDSS 4478

Query: 574  RLDLQYAKL---------LNSSK-----ARLRSLESLHSFVAAATKELMWLNEKEEEEVG 619
             + +Q  +L         L+ SK     A LR  E  HS V A    L WL E E+  + 
Sbjct: 4479 WVKVQMQELSTRWETVCALSISKQTRLEAALRQAEEFHSVVHAL---LEWLAEAEQT-LR 4534

Query: 620  FDW--SDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHP 666
            F     D    +    + +   M++LE K  ++ +    GD +L   HP
Sbjct: 4535 FHGVLPDDEDALRTLIDQHKEFMKKLEEKRAELNKATTMGDTVLAICHP 4583



 Score = 35.0 bits (79), Expect = 1.7
 Identities = 22/51 (43%), Positives = 26/51 (50%)

Query: 4435 EGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTGSRTGSRAGSRRGSFD 4485
            E +GL    AA   T+   S  + S  GS AGS+ GSR  SR GS    FD
Sbjct: 5067 EDSGLITTAAARVRTQFADSKKTPSRPGSRAGSKAGSRASSRRGSDASDFD 5117



 Score = 32.7 bits (73), Expect = 8.4
 Identities = 51/250 (20%), Positives = 90/250 (36%), Gaps = 23/250 (9%)

Query: 483  QVTLQSVQRRPELEDSTLRYLQ------DLLAWVEENQHRVDGA-EWGVDLPSVEAQLGS 535
            +V  + V+R   L+D+  R  Q       L+ W+EE++  +D   E   D   ++ QL  
Sbjct: 4275 KVVQRLVERGRSLDDARKRAKQFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQ 4334

Query: 536  HRGLHQSIEEFRAKIERARSDEGQLSPATRGA-----YRDCLGRLDLQYAKLLNSSKARL 590
            H+   +S+    +  +        L   T  A       D L  L  ++  +   S  R 
Sbjct: 4335 HKEFQKSLGAKHSVYDTTNRTGRSLKEKTSLADDNLKLDDMLSELRDKWDTICGKSVERQ 4394

Query: 591  RSLESLHSFVAAATKELM----WLNEKE----EEEVGFDWSDRNTNMTAKKESYSALMRE 642
              LE    F    T  L     WL   E    E++      D   N+    +++ A  +E
Sbjct: 4395 NKLEEALLFSGQFTDALQALIDWLYRVEPQLAEDQPVHGDIDLVMNLI---DNHKAFQKE 4451

Query: 643  LELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAY 702
            L  +   ++ L+ +   L+         V+     L T+W  +  L    +  L+     
Sbjct: 4452 LGKRTSSVQALKRSARELIEGSRDDSSWVKVQMQELSTRWETVCALSISKQTRLEAALRQ 4511

Query: 703  FQFFSDVREA 712
             + F  V  A
Sbjct: 4512 AEEFHSVVHA 4521


>gi|20357504 dystonin isoform 1eB precursor [Homo sapiens]
          Length = 3062

 Score =  787 bits (2032), Expect = 0.0
 Identities = 390/958 (40%), Positives = 640/958 (66%), Gaps = 28/958 (2%)

Query: 496  EDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARS 555
            E+  ++++QDLL WV+E Q ++D  EWG DLPSVE+ L +H+ +H++IEEF + ++ A+ 
Sbjct: 275  EEINMKFVQDLLNWVDEMQVQLDRTEWGSDLPSVESHLENHKNVHRAIEEFESSLKEAKI 334

Query: 556  DEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE 615
             E Q++   +  Y + L RL+ QYAKLLN+S+ + R L++LH+FV+ AT EL+WLNEKEE
Sbjct: 335  SEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRNQERHLDTLHNFVSRATNELIWLNEKEE 394

Query: 616  EEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ 675
            EEV +DWS+RNTN+  KK+ ++ LMREL+ KE+ IK +Q   ++LL E+HPAR T+E+++
Sbjct: 395  EEVAYDWSERNTNIARKKDYHAELMRELDQKEENIKSVQEIAEQLLLENHPARLTIEAYR 454

Query: 676  AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATV 735
            AA+QTQWSW+LQLC C+E H+KEN AYF+FF+D +EA   L+ L++A++RKYSCDRS+++
Sbjct: 455  AAMQTQWSWILQLCQCVEQHIKENTAYFEFFNDAKEATDYLRNLKDAIQRKYSCDRSSSI 514

Query: 736  TRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQ 795
             +LEDL+Q++ +EKE+L +YK  ++ L  +AK ++QLKPR+   P++  +P+ A+CDY+Q
Sbjct: 515  HKLEDLVQESMEEKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQ 574

Query: 796  VEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQ 855
            +E+T++K DEC L   +  + WKV+S +G+EA VPSVCF VPPPN+EA +   R+E Q+Q
Sbjct: 575  IEITIYKDDECVLANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ 634

Query: 856  ALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFL 915
             ++TLWH+ H++MKS+++W  L  ++  IR+ ++A+ +T+ P E +Q L +L+  ++ FL
Sbjct: 635  NVLTLWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFL 694

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
             DSQ++  F   D    E+E   C  +YQ+LL+S E+  QEES     ISE+++IRL+LE
Sbjct: 695  EDSQESQVFSGSDITQLEKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLE 754

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
             CE R + ++R PL+++   E   RI EQ+K + E+E L   +  ++ + E+  +    S
Sbjct: 755  NCEDRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAAS 814

Query: 1036 PAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQA 1095
             + PTLRSEL + L  + QV S+S+ Y++KLKT++LV++ TQ AE +++ +E +L E +A
Sbjct: 815  SSVPTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNTQAAEALVKLYETKLCEEEA 874

Query: 1096 VPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERW 1155
            V A    +E   ++LK+ R++ + ++  F AL DEL+ A+ + + + + + ERD++ +  
Sbjct: 875  VIADKNNIENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWH 934

Query: 1156 RERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP 1215
            +E+  QL+ERWQ V  Q D R R+LE +G+ L+YYR++  PL  W+Q     Q +IQ   
Sbjct: 935  KEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKIQENQ 994

Query: 1216 LADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLE-PV 1274
              +S+ +  QL Q++ L+ EIE    K++ECQ++A+QY   +KDYELQ +TY+A ++   
Sbjct: 995  PENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMVDSQQ 1054

Query: 1275 ASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA 1334
             SP K+ ++QS ++ +IQE++DLRT Y+ L TL +QYIKF  ++L+R+EEEE+  E+++ 
Sbjct: 1055 KSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEEKSLEEEKK 1114

Query: 1335 EERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQEEVVRREEAAVDAQQ 1391
            E       VE A E Q+ ++      K  AE+  K     Q+   EE+  ++E   +A Q
Sbjct: 1115 E------HVEKAKELQKWVSNISKTLK-DAEKAGKPPFSKQKISSEEISTKKEQLSEALQ 1167

Query: 1392 ----------------QKRSIQEELQQLRQSSEAEIQAKARQAEAAERS-RLRIEEEI 1432
                            ++  ++++++ L++S         +Q + ++ S  +++EE++
Sbjct: 1168 TIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDVKVEEKL 1225



 Score =  124 bits (312), Expect = 2e-27
 Identities = 101/426 (23%), Positives = 199/426 (46%), Gaps = 27/426 (6%)

Query: 3639 ETYNLL-REGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEV 3697
            E+YNLL  E  + L+E+  +            +AG     + + LS++QA+ +GL+  + 
Sbjct: 1197 ESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDT 1256

Query: 3698 ARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL--LSAERAVTGYRDPYTE 3755
               LLE Q     L+ P   +   + +A   GL+  ++  +L  LS  + +     P   
Sbjct: 1257 GIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP--- 1313

Query: 3756 QTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3815
             TI +  A+ + +I    A+++L+  L+TG +V P  G  L L+ A+Q+  ++     ++
Sbjct: 1314 TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKV 1373

Query: 3816 SEPSEV-RSYVDPSTDERLSYTQLLRRCRRDDGTGQLLLPL--SDARKLTFRGLRKQITM 3872
             E   + +  +DP T E++S   +++R    + TG  LLP+   +  ++T +   + I++
Sbjct: 1374 LERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLK-CGRNISI 1432

Query: 3873 EELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDATKERLSVYQAMK 3932
                   ++D  T  +L               + L G     G+    + +R++V +A++
Sbjct: 1433 LRAAHEGLIDRETMFRLLSA------------QLLSG-----GLINSNSGQRMTVEEAVR 1475

Query: 3933 KGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGY 3992
            +G+I   TA  +L  Q  TG +I      +LTV+EAV+  ++       +L A+R   G 
Sbjct: 1476 EGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGL 1535

Query: 3993 KDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDE 4052
              P+SG++     ++++ LI  +   ++L  +     +  PE S  + ++ A + G+ D 
Sbjct: 1536 IWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDN 1595

Query: 4053 EMNEIL 4058
                IL
Sbjct: 1596 NTASIL 1601



 Score =  119 bits (298), Expect = 7e-26
 Identities = 184/982 (18%), Positives = 398/982 (40%), Gaps = 120/982 (12%)

Query: 2142 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR 2201
            + E+   K++ ++ L+   + EQE +   L + E  + +  L+    RL  +      +R
Sbjct: 712  EKEVNVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLENCEDRLIRQI-RTPLER 770

Query: 2202 SQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARL 2261
              + E +F +  Q     KLK  +E                 L+++   +    EE    
Sbjct: 771  DDLHESVFRITEQ----EKLKKELER----------------LKDDLGTITNKCEEFFSQ 810

Query: 2262 SVAAQEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2318
            + A+     LR    +  +++ Q  +++   + +K++ V    +    AE L +  E   
Sbjct: 811  AAASSSVPTLRSELNVVLQNMNQVYSMSSTYI-DKLKTVNLVLKNTQAAEALVKLYETKL 869

Query: 2319 EQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE 2378
             +   +  DK  + + L    + ++  ++ +RQ    +  E ++ K    EM +     +
Sbjct: 870  CEEEAVIADKNNI-ENLISTLKQWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERD 928

Query: 2379 EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE 2438
             D    +++A+++ E+     +    ++  ++ +    +        L + I ++E  + 
Sbjct: 929  LDFDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQR 988

Query: 2439 KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLF 2498
            K+Q E +    K+   Q  QQ+ L+ E + ++QS + E     ++     ++       +
Sbjct: 989  KIQ-ENQPENSKTLATQLNQQKMLVSEIE-MKQSKMDECQKYAEQYSATVKDYELQTMTY 1046

Query: 2499 QDEVAKAQQLREEQQRQQ-------QQMEQERQRLVASMEEARRRQHEAEEGVRRKQEEL 2551
            +  V   Q+   +++R Q       Q+    R R  A +    +    A + ++R +EE 
Sbjct: 1047 RAMVDSQQKSPVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLEEEE 1106

Query: 2552 QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALA-------HSEEVTASQVAATKTL 2604
            + LE+++++  E   E  + +    + L++  +A           SEE++  +   ++ L
Sbjct: 1107 KSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEAL 1166

Query: 2605 PNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEA-GILSAEELQRLAQGHTTVDELARR 2663
               +  L     +   E   + L ++V    LQE+  +L +E L++L +  T+       
Sbjct: 1167 QTIQLFLAKHGDKMTDEERNE-LEKQVKT--LQESYNLLFSESLKQLQESQTS------- 1216

Query: 2664 EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRN 2723
             DV+   +    IAG + + T E LSV+ A+ R L+   T + LLE Q     L+ P   
Sbjct: 1217 GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELR 1276

Query: 2724 RRLTVNEAVKEGVVGPELHHKL--LSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGI 2781
            +   + +A   G++  ++  +L  LS  + +     P T   I +  A+ + +I     I
Sbjct: 1277 KCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAI 1333

Query: 2782 RLLEAQIATGGVIDPVHSHRVPVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLT 2841
            ++LE  ++TG ++ P    ++ +  A+++      +   + +  +  K   DP T E ++
Sbjct: 1334 KVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVS 1393

Query: 2842 YLQLLERCVEDPETGLCLLPLTDKAAKGGELVYTDSEARDVFEKATVSAPFGKFQGKTVT 2901
             + +++R      TG+ LLP+  +  +GG +                        G+ ++
Sbjct: 1394 LIDMVQRSTLQENTGMWLLPV--RPQEGGRITLK--------------------CGRNIS 1431

Query: 2902 IWEIINSEYFTAEQRRDLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPA 2961
            I                 LR    G I  E + +++                       +
Sbjct: 1432 I-----------------LRAAHEGLIDRETMFRLL-----------------------S 1451

Query: 2962 AELLESRVIDRELYQQLQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNA 3021
            A+LL   +I+    Q++   E     V + DT    L       G+      ++L++  A
Sbjct: 1452 AQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEA 1511

Query: 3022 LKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVT 3081
            ++ DL+ S  A+ +LEAQ G   +I P +        +++  L+  E   K+L+  + + 
Sbjct: 1512 VQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIA 1571

Query: 3082 GYRDPYTGQSVSLFQALKKGLI 3103
                P + Q + L  A + G+I
Sbjct: 1572 ALYIPESSQVIGLDAAKQLGII 1593



 Score =  109 bits (273), Expect = 5e-23
 Identities = 271/1372 (19%), Positives = 523/1372 (38%), Gaps = 191/1372 (13%)

Query: 1891 VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAAR- 1949
            VE  L   + V   I   ++S ++A   + ++   L    +     L S+    L  +R 
Sbjct: 308  VESHLENHKNVHRAIEEFESSLKEAKISEIQMTAPLKLTYAEKLHRLESQYAKLLNTSRN 367

Query: 1950 -QRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE- 2007
             +R L        R   E +  +   EEE A         + R K    E  R  ++ E 
Sbjct: 368  QERHLDTLHNFVSRATNELIWLNEKEEEEVAYDWSERNTNIARKKDYHAELMRELDQKEE 427

Query: 2008 -----QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAE 2062
                 QE A QL L    A+  ++A    +  A+Q +   + Q  Q  +  + +     E
Sbjct: 428  NIKSVQEIAEQLLLENHPARLTIEA----YRAAMQTQWSWILQLCQCVEQHIKENTAYFE 483

Query: 2063 AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQ 2122
                A            +EA    R +++A + K S +     R+ +    E L +E+ +
Sbjct: 484  FFNDA------------KEATDYLRNLKDAIQRKYSCD-----RSSSIHKLEDLVQESME 526

Query: 2123 EAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
            E     Q +         A   ++   + ++  L+    ++      ++++      + +
Sbjct: 527  EKEELLQYKSTIANLMGKAKTIIQLKPRNSDCPLKTSIPIKAICDYRQIEITIYKDDECV 586

Query: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
            L     R K +        + V    F+V    +E   L  RIE + +        N   
Sbjct: 587  LANNSHRAKWKVISPTGNEAMVPSVCFTVPPPNKEAVDLANRIEQQYQ--------NVLT 638

Query: 2243 FLQEEAEKMKQVAE--------EAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2294
               E    MK V          +  R S  A     L    ++ L+  ++  E  L++  
Sbjct: 639  LWHESHINMKSVVSWHYLINEIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQ 698

Query: 2295 QAV----QEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER 2350
            ++      + T+L+ E  + +Q  +   + A R +E +E +      E +  +  LE   
Sbjct: 699  ESQVFSGSDITQLEKEVNVCKQYYQELLKSAER-EEQEESVYNLYISEVRNIRLRLENCE 757

Query: 2351 QR-----------------------QLEMSAEAERLKLRVAEMSR------AQARAEEDA 2381
             R                       Q ++  E ERLK  +  ++       +QA A    
Sbjct: 758  DRLIRQIRTPLERDDLHESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQAAASSSV 817

Query: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ 2441
               R +   + + +++    +   +  ++T+ +  + +     +  EA+ +L  E +  +
Sbjct: 818  PTLRSELNVVLQNMNQVYSMSSTYIDKLKTVNLVLKNT-----QAAEALVKLY-ETKLCE 871

Query: 2442 QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL---- 2497
            +EA +    + E      +Q   E    +Q F + +D L Q+ + I  E  K  +     
Sbjct: 872  EEAVIADKNNIENLISTLKQWRSEVDEKRQVFHALEDEL-QKAKAISDEMFKTYKERDLD 930

Query: 2498 FQDEVAKAQQLREEQQRQQQQMEQERQRLVA---SMEEARRRQHEAEEGVRRKQEELQQL 2554
            F     KA QL E  Q    Q++   + L     S++  R   H  ++ +++ +   +++
Sbjct: 931  FDWHKEKADQLVERWQNVHVQIDNRLRDLEGIGKSLKYYRDTYHPLDDWIQQVETTQRKI 990

Query: 2555 EQQRRQQEELLA-------------EENQRLREQLQLLEEQHRAALAHSEEVTAS---QV 2598
            ++ + +  + LA             E  Q   ++ Q   EQ+ A +   E  T +    V
Sbjct: 991  QENQPENSKTLATQLNQQKMLVSEIEMKQSKMDECQKYAEQYSATVKDYELQTMTYRAMV 1050

Query: 2599 AATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSA------QRLQEAGILSAEELQRLAQ 2652
             + +  P  R  +   A     E  F  LR + +A      Q ++ AG    + L+RL +
Sbjct: 1051 DSQQKSPVKRRRMQSSADLIIQE--FMDLRTRYTALVTLMTQYIKFAG----DSLKRLEE 1104

Query: 2653 GHTTVDELARR--EDVRHYLQGRSSIAGLLLKA--------TNEKLSVYA-ALQRQLLSP 2701
               +++E  +   E  +   +  S+I+  L  A        + +K+S    + +++ LS 
Sbjct: 1105 EEKSLEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSE 1164

Query: 2702 GTALILLEAQAASGFLLDPVRNR------------RLTVNEAVKE-------GVVGPELH 2742
                I L        + D  RN              L  +E++K+       G V  ++ 
Sbjct: 1165 ALQTIQLFLAKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV--KVE 1222

Query: 2743 HKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRV 2802
             KL   ++ + G  D  TG+ +S+FQA+ +GLI  + GIRLLE Q+   G+I P      
Sbjct: 1223 EKL---DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCF 1279

Query: 2803 PVDVAYRRGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPL 2862
             +  A   G  DE++   L + S   +      +  + T + +L+   +   T    + +
Sbjct: 1280 DLKDAKSHGLIDEQILCQLKELSKAKEII----SAASPTTIPVLDALAQSMITESMAIKV 1335

Query: 2863 TDKAAKGGELVYTDSEARDVFEKA-----TVSAPFGKFQGKTVTIWEIINSEYFTAEQRR 2917
             +     G LV   +  +   +KA       SA F K   +     ++I+          
Sbjct: 1336 LEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLI 1395

Query: 2918 DLLRQFRTGRITVEKIIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQ 2977
            D+++     R T+++   + +  V  QE  GR+  +  R+ +         +IDRE    
Sbjct: 1396 DMVQ-----RSTLQENTGMWLLPVRPQEG-GRITLKCGRN-ISILRAAHEGLIDRE---- 1444

Query: 2978 LQRGERSVRDVAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLE 3037
                           T+ R L    +  G+    +GQ++++  A+++ ++  D A ++L 
Sbjct: 1445 ---------------TMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILT 1489

Query: 3038 AQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQA 3097
             Q  TG II    + RLTVDEAV+  L+       +L A++   G   P++G+      +
Sbjct: 1490 YQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSS 1549

Query: 3098 LKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRAL 3149
            L++ LI  E   ++L+ +     +  P  S  + LD A   G +D  T+  L
Sbjct: 1550 LQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601



 Score = 90.5 bits (223), Expect = 3e-17
 Identities = 85/405 (20%), Positives = 172/405 (42%), Gaps = 35/405 (8%)

Query: 3743 ERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVDPRLGFHLPLEVAY 3802
            ++ + G  D  T + +S+FQA+ + LI  +  +RLL+ QL   G++ P L     L+ A 
Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285

Query: 3803 QRGYLNKDTHDQLSEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGTG-QLLLPLSDARKL 3861
              G +++    QL E S+ +  +  ++   +     L +    +    ++L  L     L
Sbjct: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345

Query: 3862 TFRGLRKQITMEELVRSQVMDEATALQLREGLTSIEEVTKNLQKFLEGTSCIAGVFVDAT 3921
                  +Q+T+++  +  ++  A                    K LE  +    +    T
Sbjct: 1346 VIPATGEQLTLQKAFQQNLVSSAL-----------------FSKVLERQNMCKDLIDPCT 1388

Query: 3922 KERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDK 3981
             E++S+   +++  ++  T   LL  +   G  I    G  +++  A   G++  E   +
Sbjct: 1389 SEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLIDRETMFR 1448

Query: 3982 LLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPV 4041
            LLSA+    G  +  SG+ +++ +A+++G+I +D    +L  Q+ TGGII    + RL V
Sbjct: 1449 LLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTV 1508

Query: 4042 EVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENL-TYLQLMERCITDPQTGLCLLPLK 4100
            + A +  L       ++ +      G   P++ E   T   L +  IT+      L    
Sbjct: 1509 DEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKIL---- 1564

Query: 4101 EKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQT 4145
                        + R++   +  PE+ + + +  A + G+ID+ T
Sbjct: 1565 ------------NGRQKIAALYIPESSQVIGLDAAKQLGIIDNNT 1597



 Score = 90.1 bits (222), Expect = 4e-17
 Identities = 97/443 (21%), Positives = 184/443 (41%), Gaps = 86/443 (19%)

Query: 3986 ERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEESHRLPVEVAY 4045
            ++ + G  D  +G+++S+FQA+ +GLI  D GIRLLE Q+   G+I PE      ++ A 
Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285

Query: 4046 KRGLFDEEM----------NEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQTGLC 4095
              GL DE++           EI++  S  T    D   +  +T    ++       TG  
Sbjct: 1286 SHGLIDEQILCQLKELSKAKEIISAASPTTIPVLDALAQSMITESMAIKVLEILLSTGSL 1345

Query: 4096 LLP-------LKEKKRERKTSSK--SSVRKRRVV---IVDPETGKEMSVYEAYRKGLIDH 4143
            ++P       L++  ++   SS   S V +R+ +   ++DP T +++S+ +  ++  +  
Sbjct: 1346 VIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQE 1405

Query: 4144 QTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAG 4203
             T + L         + +   +G      I  + GR   I  A  + LIDR  + +  + 
Sbjct: 1406 NTGMWL---------LPVRPQEGGR----ITLKCGRNISILRAAHEGLIDRETMFRLLS- 1451

Query: 4204 TLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTEETGPVAGILD 4263
                   A +LSG                                           G+++
Sbjct: 1452 -------AQLLSG-------------------------------------------GLIN 1461

Query: 4264 TETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIM 4323
            + + +++++ EA+   ++D  T   +L  Q  TGGII  +  +R  V +AV   L+    
Sbjct: 1462 SNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSS 1521

Query: 4324 VDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGR 4383
               +  AQ+ + G   P +      + +L++  +  E   + L  +     L  P++   
Sbjct: 1522 ALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQV 1581

Query: 4384 VPLDEALQRGTVDARTAQKLRDV 4406
            + LD A Q G +D  TA  L+++
Sbjct: 1582 IGLDAAKQLGIIDNNTASILKNI 1604



 Score = 88.2 bits (217), Expect = 2e-16
 Identities = 111/476 (23%), Positives = 194/476 (40%), Gaps = 44/476 (9%)

Query: 3077 EKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVAC 3136
            +K + G  D  TG+ +S+FQA+ +GLI  + G+RLL+ QL   G++ P       L  A 
Sbjct: 1226 DKVIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAK 1285

Query: 3137 ARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAAR 3196
            + G +DE+    L   +  +KA    S   P T                  +P+ +  A+
Sbjct: 1286 SHGLIDEQI---LCQLKELSKAKEIISAASPTT------------------IPVLDALAQ 1324

Query: 3197 ARQEELYSELQARETFEKTPVEVPVGGFKGRTVTVWE--LISSEYFTAEQRQELLRQFRT 3254
            +   E  +            + +P  G +      ++  L+SS  F+    ++ + +   
Sbjct: 1325 SMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLI 1384

Query: 3255 GKVTVEKVIKILITIVEEVETLRQERLSFSGLRAPVPASELLASG---VLSRAQFEQLKD 3311
               T EKV   LI +V+         +    +R        L  G    + RA  E L D
Sbjct: 1385 DPCTSEKVS--LIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID 1442

Query: 3312 GKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQA 3371
             +T  + LS       LL G     G+   ++ +++++ EA+R G++   TA+ +L  Q 
Sbjct: 1443 RETMFRLLSA-----QLLSG-----GLINSNSGQRMTVEEAVREGVIDRDTASSILTYQV 1492

Query: 3372 ATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQK 3431
             TG ++     +RL V EAV+  ++       +L A++   G   P+SG       ++Q+
Sbjct: 1493 QTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQ 1552

Query: 3432 GLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPS--DDTKG 3489
             L+  +   ++L  +     +  P  S  + +D A Q G        +L + +  D    
Sbjct: 1553 ELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASILKNITLPDKMPD 1612

Query: 3490 FFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYTEEETRRAF 3545
              D    +N   R+ L  C   P T       +     E   TTQ  T EET++ F
Sbjct: 1613 LGDLEACKNA--RRWLSFCKFQPSTVHDYRQEEDVFDGEEPVTTQ--TSEETKKLF 1664



 Score = 85.9 bits (211), Expect = 8e-16
 Identities = 88/421 (20%), Positives = 179/421 (42%), Gaps = 39/421 (9%)

Query: 3300 VLSRAQFEQLKDGKTTVKDLSELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLR 3359
            +L     +QL++ +T+       G V+   +    +AG   + T E +S+++A+ RGL+ 
Sbjct: 1201 LLFSESLKQLQESQTS-------GDVKVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLID 1253

Query: 3360 ATTAALLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQL--LSAEKAVTGYRDP 3417
              T   LLE Q     L+ P   +   + +A   G++  ++  QL  LS  K +     P
Sbjct: 1254 YDTGIRLLETQLMISGLISPELRKCFDLKDAKSHGLIDEQILCQLKELSKAKEIISAASP 1313

Query: 3418 YSGSTISLFQAMQKGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMN 3477
               +TI +  A+ + ++     I++LE  ++TG ++ P    ++ +  A+Q+   S  + 
Sbjct: 1314 ---TTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSALF 1370

Query: 3478 RVLADPSDDTKGFFDPNTHENLTYRQLLERCVEDPETGLRLLPLKGAEKAEVVETTQVYT 3537
              + +  +  K   DP T E ++   +++R      TG+ LLP++  E   +  T +   
Sbjct: 1371 SKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRI--TLKCGR 1428

Query: 3538 EEETRRAFEETQID------------IPGG--GSHGGSTMSLWEVMQSDLIPEEQRAQLM 3583
                 RA  E  ID            + GG   S+ G  M++ E ++  +I  +  + ++
Sbjct: 1429 NISILRAAHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSIL 1488

Query: 3584 A-DFQAGRVTKERMI--IIIIEIIEKTEIIRQQGLASYDYVRRRLTAEDLFEARIISLET 3640
                Q G + +      + + E ++   I     L   +  R  +         +I   +
Sbjct: 1489 TYQVQTGGIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYV--------GLIWPHS 1540

Query: 3641 YNLLREGTRSLREALEAESAWCYLYGTGSVAGVYLPGSRQTLSIYQALKKGLLSAEVARL 3700
              +    +   +E +  E A+  L G   +A +Y+P S Q + +  A + G++    A +
Sbjct: 1541 GEIFPTSSSLQQELITNELAYKILNGRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASI 1600

Query: 3701 L 3701
            L
Sbjct: 1601 L 1601



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 116/517 (22%), Positives = 208/517 (40%), Gaps = 56/517 (10%)

Query: 3958 IKGLKLTVEEAVRMGIVGPEFKDKLLSAERAVTGYKDPYSGKL--ISLFQAMKKGLILKD 4015
            +  +  T+++A + G   P F  + +S+E   T  K+  S  L  I LF A K G  + D
Sbjct: 1127 VSNISKTLKDAEKAG--KPPFSKQKISSEEISTK-KEQLSEALQTIQLFLA-KHGDKMTD 1182

Query: 4016 HGIRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEILTDPSDDT--KGFFDPNT 4073
                 LE Q+ T      +ES+ L    + K+    +   ++  +   D    G  D  T
Sbjct: 1183 EERNELEKQVKT-----LQESYNLLFSESLKQLQESQTSGDVKVEEKLDKVIAGTIDQTT 1237

Query: 4074 EENLTYLQLMERCITDPQTGLCLLPLKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVY 4133
             E L+  Q + R + D  TG+ LL         +T    S       ++ PE  K   + 
Sbjct: 1238 GEVLSVFQAVLRGLIDYDTGIRLL---------ETQLMISG------LISPELRKCFDLK 1282

Query: 4134 EAYRKGLIDHQTYLELSEQECEWEEITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLID 4193
            +A   GLID Q   +L E     E I+ +S   +               + DA+A+++I 
Sbjct: 1283 DAKSHGLIDEQILCQLKELSKAKEIISAASPTTI--------------PVLDALAQSMIT 1328

Query: 4194 RSALDQYRAGTLSITEFADMLSGNAGGFRSRSSSVGSSSSYPISPAVSRTQLASWSDPTE 4253
             S         ++I     +LS  +    +    +    ++  +   S    A +S   E
Sbjct: 1329 ES---------MAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSS----ALFSKVLE 1375

Query: 4254 ETGPVAGILDTETLEKVSITEAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDA 4313
                   ++D  T EKVS+ + + R+ +   TG  LL  +   GG I    G    +  A
Sbjct: 1376 RQNMCKDLIDPCTSEKVSLIDMVQRSTLQENTGMWLLPVRPQEGGRITLKCGRNISILRA 1435

Query: 4314 VNKGLVDKIMVDRINLAQKAFCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTG 4373
             ++GL+D+  + R+  AQ    G  +  +  +M+  +A+++G +  +     L  Q  TG
Sbjct: 1436 AHEGLIDRETMFRLLSAQLLSGGLINSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTG 1495

Query: 4374 GLIEPDTPGRVPLDEALQRGTVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMV 4433
            G+I+ +   R+ +DEA+Q   + + +A  + +       L  P +        +L + ++
Sbjct: 1496 GIIQSNPAKRLTVDEAVQCDLITSSSALLVLEAQRGYVGLIWPHSGEIFPTSSSLQQELI 1555

Query: 4434 EEGTGLRLLEAAAQSTKGYYSPYSVSGSGSTAGSRTG 4470
                  ++L    Q     Y P S    G  A  + G
Sbjct: 1556 TNELAYKILN-GRQKIAALYIPESSQVIGLDAAKQLG 1591



 Score = 72.0 bits (175), Expect = 1e-11
 Identities = 90/396 (22%), Positives = 161/396 (40%), Gaps = 54/396 (13%)

Query: 3003 VIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRA 3062
            VIAG   +  G+ LS++ A+ + L+  D  + LLE Q     +I P       + +A   
Sbjct: 1228 VIAGTIDQTTGEVLSVFQAVLRGLIDYDTGIRLLETQLMISGLISPELRKCFDLKDAKSH 1287

Query: 3063 GLVGPEF--HEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGG 3120
            GL+  +     K LS  K +     P T   + +  AL + +I     +++L+  LSTG 
Sbjct: 1288 GLIDEQILCQLKELSKAKEIISAASPTT---IPVLDALAQSMITESMAIKVLEILLSTGS 1344

Query: 3121 IVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPD 3180
            +V P+   ++ L  A  +  +       +   +   K   DP T E  +  ++ QR    
Sbjct: 1345 LVIPATGEQLTLQKAFQQNLVSSALFSKVLERQNMCKDLIDPCTSEKVSLIDMVQRSTLQ 1404

Query: 3181 QLTGLSLLPLSEKAA--------------RARQEELYSELQARET-FEKTPVEVPVGGF- 3224
            + TG+ LLP+  +                RA  E L      RET F     ++  GG  
Sbjct: 1405 ENTGMWLLPVRPQEGGRITLKCGRNISILRAAHEGLID----RETMFRLLSAQLLSGGLI 1460

Query: 3225 ---KGRTVTVWELISSEYFTAEQRQELLR-QFRTG---------KVTVEKVIKI-LITIV 3270
                G+ +TV E +       +    +L  Q +TG         ++TV++ ++  LIT  
Sbjct: 1461 NSNSGQRMTVEEAVREGVIDRDTASSILTYQVQTGGIIQSNPAKRLTVDEAVQCDLITSS 1520

Query: 3271 EEVETLRQERLSFSGLRAPVPASELLASGVLSRAQFEQLKDGKTTVKDLSELGSVRTLLQ 3330
              +  L  +R  + GL  P        S  L     ++L   +   K          +L 
Sbjct: 1521 SALLVLEAQR-GYVGLIWPHSGEIFPTSSSLQ----QELITNELAYK----------ILN 1565

Query: 3331 GSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALL 3366
            G   +A +Y+ ++ + + +  A + G++   TA++L
Sbjct: 1566 GRQKIAALYIPESSQVIGLDAAKQLGIIDNNTASIL 1601



 Score = 64.3 bits (155), Expect = 3e-09
 Identities = 34/98 (34%), Positives = 61/98 (62%)

Query: 368 RLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMI 427
           RLE LQ+I  ++Q ++ +CE++L  A   LQSD + L +G   Q   E+   + + ++++
Sbjct: 56  RLEMLQQIANRVQRDSVICEDKLILAGNALQSDSKRLESGVQFQNEAEIAGYILECENLL 115

Query: 428 RLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTE 465
           R    DVQ L DG++ Q +Q+ +RV +L + ++A+R E
Sbjct: 116 RQHVIDVQILIDGKYYQADQLVQRVAKLRDEIMALRNE 153



 Score = 48.9 bits (115), Expect = 1e-04
 Identities = 153/788 (19%), Positives = 303/788 (38%), Gaps = 97/788 (12%)

Query: 1534 EVERARQVQVA-----LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588
            E++R R   VA     L    +   + LQS+   F E + + +     +   + QL +E 
Sbjct: 659  EIDRIRASNVASIKTMLPGEHQQVLSNLQSRFEDFLEDSQESQVFSGSD---ITQLEKEV 715

Query: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648
                Q   E  ++ E  E+E   + L  +E   +RL+ E   + + + Q     ++++  
Sbjct: 716  NVCKQYYQELLKSAEREEQEESVYNLYISEVRNIRLRLEN-CEDRLIRQIRTPLERDDL- 773

Query: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETE---QGEQ 1705
             E+  R   +E+  ++ E  + +L       E    Q  AA   +  LR+E     Q   
Sbjct: 774  HESVFRITEQEKLKKELERLKDDLGTITNKCEEFFSQ-AAASSSVPTLRSELNVVLQNMN 832

Query: 1706 QRQLLEEELARLQREAAAATQKRQELEAELAKV----RAEMEVLLASKARAEEESRSTSE 1761
            Q   +        +      +  Q  EA L K+      E E ++A K    E   ST +
Sbjct: 833  QVYSMSSTYIDKLKTVNLVLKNTQAAEA-LVKLYETKLCEEEAVIADKNNI-ENLISTLK 890

Query: 1762 KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIG 1821
            + +  ++ +   F  L +E  + +A+++E  +  +  + D    + +A+++       + 
Sbjct: 891  QWRSEVDEKRQVFHALEDELQKAKAISDEMFKTYKERDLDFDWHKEKADQL-------VE 943

Query: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
                +  + +  L++ E   + L +   D         +Q    +  I+E   +  K   
Sbjct: 944  RWQNVHVQIDNRLRDLEGIGKSL-KYYRDTYHPLDDWIQQVETTQRKIQENQPENSKTLA 1002

Query: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
            ++L +QK LV +   ++ +++E     +   E+ +A   + EL+    R+  +   +S  
Sbjct: 1003 TQLNQQKMLVSEIEMKQSKMDE----CQKYAEQYSATVKDYELQTMTYRAMVDSQQKS-- 1056

Query: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001
                   ++R++ +  +   +E  +   +  A      +  K A + ++RL+   EE + 
Sbjct: 1057 -----PVKRRRMQSSADLIIQEFMDLRTRYTALVTLMTQYIKFAGDSLKRLE---EEEKS 1108

Query: 2002 LRERAEQ--ESARQLQLAQEAAQKRLQAEEKA----------HAFAVQQKEQELQQTLQQ 2049
            L E  ++  E A++LQ       K L+  EKA           +  +  K+++L + LQ 
Sbjct: 1109 LEEEKKEHVEKAKELQKWVSNISKTLKDAEKAGKPPFSKQKISSEEISTKKEQLSEALQT 1168

Query: 2050 EQSVLDQLRGEAEAARRAAEEAEEARVQAERE--AAQSRRQVEEAERLKQSAEEQAQARA 2107
             Q  L         A+   +  +E R + E++    Q    +  +E LKQ  E Q     
Sbjct: 1169 IQLFL---------AKHGDKMTDEERNELEKQVKTLQESYNLLFSESLKQLQESQTSGDV 1219

Query: 2108 QAQAAAEK-LRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2166
            + +   +K +    +Q         QA LR     D                        
Sbjct: 1220 KVEEKLDKVIAGTIDQTTGEVLSVFQAVLRGLIDYD------------------------ 1255

Query: 2167 TTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIE 2226
            T +RL LE       L+  EL+  K    + A+    ++E++     Q++ELSK K  I 
Sbjct: 1256 TGIRL-LETQLMISGLISPELR--KCFDLKDAKSHGLIDEQIL---CQLKELSKAKEIIS 1309

Query: 2227 AENRALI-LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAL 2285
            A +   I + D        +  A K+ ++      L + A       Q A +      AL
Sbjct: 1310 AASPTTIPVLDALAQSMITESMAIKVLEILLSTGSLVIPATGEQLTLQKAFQQNLVSSAL 1369

Query: 2286 AEKMLKEK 2293
              K+L+ +
Sbjct: 1370 FSKVLERQ 1377


>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
          Length = 2390

 Score =  431 bits (1107), Expect = e-119
 Identities = 553/2250 (24%), Positives = 910/2250 (40%), Gaps = 310/2250 (13%)

Query: 8    QNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP 67
            ++ I +L DER+ VQKKTFTKWVN HL +    + DLY DLRDG NL+ LLEVLSG+ LP
Sbjct: 45   RSRIKALADEREAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEILP 104

Query: 68   RE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 126
            +  KGRMR H L+NV  AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI D
Sbjct: 105  KPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQIQD 164

Query: 127  IQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184
            I V  +   E  +AK+ LLLW Q    GY  +   NFT+SWRDG  FNAI+H+H+P L+D
Sbjct: 165  ISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLLD 224

Query: 185  MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244
               + +     NL  AF++AE++LG+T+LLDPEDV+V QPDEKSIITYV++ Y    ++ 
Sbjct: 225  FESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATYYHYFSKMK 284

Query: 245  DVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 296
             +  +G R       A E +   ++Y  L   LLQW+        +R+  +S   ++   
Sbjct: 285  ALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQWIEQTIVTLNDRQLANSLSGVQNQL 344

Query: 297  SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHV 353
              F  ++ +E P K  +K   + +  +++  ++A   KV     G    D+ K W +L  
Sbjct: 345  QSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANNQKVYTPREGRLISDINKAWERLEK 404

Query: 354  AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVP 410
            A  ERE  LR+E  R E L+++  +   +A + E  L++   L+  D   + L A     
Sbjct: 405  AEHERELALRTELIRQEKLEQLAARFDRKAAMRETWLSENQRLVSQDNFGLELAAVEAAV 464

Query: 411  QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRL 470
            ++   +E D       I      VQ +         + Y  + R+  R   +   ++   
Sbjct: 465  RKHEAIETD-------IVAYSGRVQAVDAVAAELAAERYHDIKRIAARQHNVARLWDFLR 517

Query: 471  KAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVE 530
            +   A     +  + LQ V +        L YL D   W+EE + R+   + G  L  VE
Sbjct: 518  QMVAARRERLLLNLELQKVFQ-------DLLYLMD---WMEEMKGRLQSQDLGRHLAGVE 567

Query: 531  AQLGSHRGLHQSIE-EFRAKIERARS-DEGQLSPATRG-AYRDC--------LGRLDLQY 579
              L     LH+ +E +   + ER R+     L     G  YR C        + +L+  Y
Sbjct: 568  DLL----QLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAKLEQSY 623

Query: 580  ---AKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 636
                +L  + +ARL     L  F+    +   W+ E++      D     T        +
Sbjct: 624  EALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALRLLNKH 683

Query: 637  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 696
            +AL  E+  +   +K     G +L+ E HP      +  A LQ QW  +  L       L
Sbjct: 684  TALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRL 743

Query: 697  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756
             + A+ +QF +D  + E     L +ALR   S +        + L +  +  +E++  ++
Sbjct: 744  AQAASLYQFQADANDMEAW---LVDALRLVSSPELGHDEFSTQALARQHRALEEEIRSHR 800

Query: 757  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSH 816
              L  L ++A A+     R P   ++GR+P L                           H
Sbjct: 801  PTLDALREQAAALPPTLSRTP--EVQGRVPTL-------------------------ERH 833

Query: 817  WKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEA--QHQALVTLWHQLHVDMKSLLAW 874
            ++ L +   E A              A EA   L           LW +      + LA 
Sbjct: 834  YEELQARAGERA-------------RALEAALALYTMLSEAGACGLWVEEKEQWLNGLAL 880

Query: 875  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934
                 D+++++      F TL+PE    A     ++  A      +  G   +DR++  +
Sbjct: 881  PERLEDLEVVQQ----RFETLEPEMNTLAAQITAVNDIAEQLLKANPPG---KDRIVNTQ 933

Query: 935  EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 994
            E    +H +QQ  + L  G +         S L      LE  ET+   R          
Sbjct: 934  E--QLNHRWQQ-FRRLADGKK-----AALTSALSIQNYHLECTETQAWMR---------- 975

Query: 995  RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1054
                    E+ K     +GLG  +A + A   K+        A      EL        +
Sbjct: 976  --------EKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGEL------TRE 1021

Query: 1055 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRA----HEEQLKEAQAV-------------- 1096
              +L+A +  +   I+  +R  Q   E LRA     EE L EA+ +              
Sbjct: 1022 ANALAAGHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWL 1081

Query: 1097 ------------PATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR 1144
                        PATLPE EA  A    LR + E  Q  +  LR        +GE + + 
Sbjct: 1082 GRTQTAVASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRLR-------ALGEEVTR- 1133

Query: 1145 HGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA 1204
              + D +    R+R+  L   W+ +    + RQ  L Q           A     +L+DA
Sbjct: 1134 -DQADPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQ-----------AHGFQGFLRDA 1181

Query: 1205 RRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1256
            R+ +  + +     S        QA    +++ +  +  ++ +GE++       +Q ++ 
Sbjct: 1182 RQAEGVLSSQEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVS- 1240

Query: 1257 IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFIS 1316
                E  +   K + +  +   +  K Q  ++  +    D R           Q+     
Sbjct: 1241 ----EGNIHADKIREKADSIERRHKKNQDAAQQFLGRLRDNR---------EQQHFLQDC 1287

Query: 1317 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQ 1376
              L+   +E+ L  Q  + +  R   +    +K +      A  K   ++  KE      
Sbjct: 1288 HELKLWIDEKMLTAQDVSYDEAR--NLHTKWQKHQAFMAELAANKDWLDKVDKE------ 1339

Query: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQ---SSEAEIQAKARQAEAAERSRLRIEE--- 1430
                   E  ++  + K  + E+L+ L +     E   QAKAR    A R+ L  +    
Sbjct: 1340 -----GRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSLFDANRAELFAQSCCA 1394

Query: 1431 -EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR 1489
             E  +  LQ +      G     +  L  + +  E +    ++E E ++ Q +  +Q  +
Sbjct: 1395 LESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEVEAIQAQAKALAQEDQ 1454

Query: 1490 QA-EVELASRVKAEAEAAREKQRAL-QALEE--LRLQAEEAERRLRQAEVERARQVQVAL 1545
             A EVE  SR      A  EK RAL Q + E   RLQA   + +  +   +    V   L
Sbjct: 1455 GAGEVERTSR------AVEEKFRALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERL 1508

Query: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE-----AERRAQQQAEAER 1600
              A      +         +K   L++ +Q     +A LRE      A     + AE + 
Sbjct: 1509 PMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE 1568

Query: 1601 AREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQ 1660
              +    ELE    +  +ALR        AQQ     AEAE    E E     + KA+++
Sbjct: 1569 MWKRLGHELELRGKRLEDALR--------AQQFYRDAAEAEAWMGEQELHMMGQEKAKDE 1620

Query: 1661 AVRQRELAE-QELEKQRQLAEGTAQQRLAAEQELI--------RLRAETEQ--------- 1702
               Q E+ + Q LE+       T  Q  A+ Q++I        R+     Q         
Sbjct: 1621 LSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK 1680

Query: 1703 ---GEQQRQLLEE-ELARLQREAAAATQKRQELEAELA--KVRAEMEVLLASKARAEEES 1756
               GE++ +L E   L +L+RE     Q  QE E   A  ++  + E +   + +  E S
Sbjct: 1681 ELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFS 1740

Query: 1757 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK 1816
            R TS   ++R+++       L       RA   E K     A  D      E      + 
Sbjct: 1741 RDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADL----LELLDTRGQV 1796

Query: 1817 LAAIGEATRLKTEAEIALKEKEAENERL-----RRLAEDEAFQRRRLEEQAAQHKADIEE 1871
            LAA  E  R    A  AL   + + ++L     R L   EA QRR        ++ DI+ 
Sbjct: 1797 LAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEALQRRH-----CAYEHDIQA 1851

Query: 1872 RLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
               Q+++  D     QK    D   +  +  + +    A  + ++A + +L L+      
Sbjct: 1852 LSPQVQQVQDDGHRLQKAYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLD------ 1905

Query: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
               D  R       +A R+  L  +E   + +A+ER +   +A+     Q+    E    
Sbjct: 1906 -TTDKFRF-----FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAE---- 1955

Query: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
            ++A+ +      +  ++  AR    A+E ++K  Q + +      Q+  ++ Q+ +   Q
Sbjct: 1956 IEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR-----QETAEKWQEKMDWLQ 2010

Query: 2052 SVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA 2111
             VL+ L    +A    A    +  +    E   +  +VE   +  ++ ++ A A  +   
Sbjct: 2011 LVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEERFC 2070

Query: 2112 AAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
            A EKL    E+E  R+ + E+   R++  A
Sbjct: 2071 ALEKLTALEEREKERKRKREEEERRKQPPA 2100



 Score =  123 bits (309), Expect = 4e-27
 Identities = 354/1688 (20%), Positives = 644/1688 (38%), Gaps = 261/1688 (15%)

Query: 1144 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1203
            R G    ++ +  ER+ +     +  L    +RQ +LEQL    R+ R++A     WL +
Sbjct: 387  REGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQLAA--RFDRKAA-MRETWLSE 443

Query: 1204 ARRRQEQIQ-AMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYEL 1262
             +R   Q    + LA   AV   +R+ +A+  +I  +  +V+     A + + A + +++
Sbjct: 444  NQRLVSQDNFGLELA---AVEAAVRKHEAIETDIVAYSGRVQAVDAVAAE-LAAERYHDI 499

Query: 1263 QLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRM 1322
            + +  +           +  V +  E ++   ++L+  + +L  L   +++ +   L+  
Sbjct: 500  KRIAARQHNVARLWDFLRQMVAARRERLLLN-LELQKVFQDLLYLMD-WMEEMKGRLQSQ 557

Query: 1323 EEEERLAEQQRAEERERLAEVEAALEKQRQLA-EAHAQAKAQAEREAKELQ-QRMQEEVV 1380
            +    LA  +   +   L E + A++ +R  A  A A       +E +    Q + E V 
Sbjct: 558  DLGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVA 617

Query: 1381 RRE---EAAVDAQQQKRSIQEELQQLRQ------SSEAEIQAKARQAEAAERSR------ 1425
            + E   EA  +    +R+  EE ++L +       +EA ++ +     +A+  R      
Sbjct: 618  KLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGAL 677

Query: 1426 --------LRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477
                    LR E   R+  L+L   + Q+  AEG   A +A A  AE Q +      ERL
Sbjct: 678  RLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQW-----ERL 732

Query: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL----------EELRLQAEEAE 1527
                ++ +QR  QA    AS  + +A+A   +   + AL          +E   QA   +
Sbjct: 733  EALAEERAQRLAQA----ASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQ 788

Query: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587
             R  + E+   R    AL   Q +A     S+      +   LER  +E      +    
Sbjct: 789  HRALEEEIRSHRPTLDALRE-QAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARA 847

Query: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK--------SLAQAE 1639
             E           A        E+ Q     AL  RL+  EV QQ+        +   A+
Sbjct: 848  LEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQ 907

Query: 1640 AEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----------QQRLAA 1689
                 + AE+  +     +++ V  +E      ++ R+LA+G               L  
Sbjct: 908  ITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLEC 967

Query: 1690 EQELIRLRAETEQGEQQRQL---------LEEELARLQREAAAATQKRQELEAE---LAK 1737
             +    +R +T+  E  + L         L+ +LA  +R+  A   +  EL  E   LA 
Sbjct: 968  TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027

Query: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRAL-AEEAKRQRQ 1796
                  V + ++ R  +        + +R E   G  R L +    L    A   + Q  
Sbjct: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087

Query: 1797 LAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAE----DEA 1852
            +A E+      EAE +LA+  A  GE  R            ++E  RLR L E    D+A
Sbjct: 1088 VASEEGPATLPEAEALLAQHAALRGEVERA-----------QSEYSRLRALGEEVTRDQA 1136

Query: 1853 -----FQRRRLE------EQAAQHKADIEERLAQ-------LRKASDSE--LERQKGLVE 1892
                 F R+RLE      E+  +     + RLAQ       LR A  +E  L  Q+ ++ 
Sbjct: 1137 DPQCLFLRQRLEALGTGWEELGRMWESRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVLS 1196

Query: 1893 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1952
             T     ++   + A  A+ +K     + ++    RI    E   +   +  + A + R+
Sbjct: 1197 HT-----EMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIRE 1251

Query: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR 2012
             A   ERR ++ ++  Q+ L    +  R+++  L++   LK  ++E     +    + AR
Sbjct: 1252 KADSIERRHKKNQDAAQQFLGRLRDN-REQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310

Query: 2013 QLQ---------LAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVL----DQLRG 2059
             L          +A+ AA K    +       +  ++ EL+  + ++   L    D+L  
Sbjct: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELET 1370

Query: 2060 EAEAARRAAEEAEEARVQAEREAAQS------RRQVEEAERLKQSAEEQAQARAQAQAAA 2113
              +A  R+  +A  A + A+   A        + Q+   +  K         + Q     
Sbjct: 1371 TTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEW 1430

Query: 2114 EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQL 2173
            E   +E E EA    QA+  AL Q+     E+E+  +  E+  R   Q  +E    RLQ 
Sbjct: 1431 EMAVREKEVEAI---QAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCR-RLQA 1486

Query: 2174 EETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI 2233
                HQ +                      VE+E+  V  ++   S ++   +  +  L+
Sbjct: 1487 SREQHQFH--------------------RDVEDEILWVTERLPMASSMEHGKDLPSVQLL 1526

Query: 2234 LRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ--EAARLRQLAEEDLAQQRALAEKMLK 2291
            ++     Q+ +Q    ++  + E    L  AA   E A L+++ +  L  +  L  K L+
Sbjct: 1527 MKKNQTLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKR-LGHELELRGKRLE 1585

Query: 2292 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQ 2351
            + ++A Q+  R  AEAE    ++EL              M Q+ A++             
Sbjct: 1586 DALRA-QQFYRDAAEAEAWMGEQEL------------HMMGQEKAKD------------- 1619

Query: 2352 RQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT 2411
               E+SA+AE  K +V E + A                +  + +H+   ++Q+ +     
Sbjct: 1620 ---ELSAQAEVKKHQVLEQALA----------------DYAQTIHQLAASSQDMIDHEHP 1660

Query: 2412 LEIQRQQSDHDAERLREAIAELEREK-EKLQQEAKLLQLKSEE---MQTVQQEQLLQETQ 2467
               +        ++L   + EL  E+ E+LQ+  +L QL+ E     Q +Q+ +++  + 
Sbjct: 1661 ESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASH 1720

Query: 2468 ALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLV 2527
             L Q +   +   + R++F E  +     + Q+ V  A  L                 L+
Sbjct: 1721 ELGQDY---EHVTMLRDKFREFSR-DTSTIGQERVDSANALANG--------------LI 1762

Query: 2528 ASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAAL 2587
            A    AR    E ++ +     +L +L   R Q   +LA   +     LQ      R AL
Sbjct: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQ---VLAAAYE-----LQRFLHGARQAL 1814

Query: 2588 AHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEEL 2647
            A  +         T    N  +AL         EH    L  +V  Q++Q+ G      L
Sbjct: 1815 ARVQHKQQQLPDGTGRDLNAAEALQ--RRHCAYEHDIQALSPQV--QQVQDDG----HRL 1866

Query: 2648 QRLAQGHTTVDELARR----EDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGT 2703
            Q+   G    +E+ R      +    LQG S+    LL  T +K   + A++  +L    
Sbjct: 1867 QKAYAGDKA-EEIGRHMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDE 1925

Query: 2704 ALILLEAQ 2711
              + ++AQ
Sbjct: 1926 VNLQMDAQ 1933



 Score =  122 bits (307), Expect = 6e-27
 Identities = 352/1639 (21%), Positives = 616/1639 (37%), Gaps = 217/1639 (13%)

Query: 1102 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1161
            EL A +A+++K     EA +    A    ++    V   L     ER  +++R   R   
Sbjct: 456  ELAAVEAAVRK----HEAIETDIVAYSGRVQAVDAVAAELA---AERYHDIKRIAARQHN 508

Query: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221
            +   W   L Q    +RE   L  +L+   +    L  W+++ + R   +Q+  L    A
Sbjct: 509  VARLWD-FLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGR---LQSQDLGRHLA 564

Query: 1222 VREQLRQEQALLE-EIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKK 1280
              E L Q   L+E +I    E+V      A ++ N  K+Y           +P     + 
Sbjct: 565  GVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYR--------PCDPQLVSERV 616

Query: 1281 PKVQSGSESVIQEYVDLRTHYSELTTL---------------TSQYIKFISETLRRMEEE 1325
             K++   E++ +     R    E   L                 Q++   ++T R +   
Sbjct: 617  AKLEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGA 676

Query: 1326 ERLAEQQ---RAEERERLAEVEAALEKQRQL-AEAHAQAKAQAEREAKELQQRMQEEVVR 1381
             RL  +    R E   RL  ++  LE+ +QL AE H  A +QA   A ELQ + +     
Sbjct: 677  LRLLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGA-SQASARAAELQAQWERLEAL 735

Query: 1382 REEAAVDAQQQKRSIQEE----------LQQLRQSSEAEIQAKARQAEAAERSRLRIEEE 1431
             EE A    Q     Q +          +  LR  S  E+       +A  R    +EEE
Sbjct: 736  AEERAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEE 795

Query: 1432 IRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA 1491
            IR  R  L+A   Q       L    +R  E + +    +   E L+ +     +R R  
Sbjct: 796  IRSHRPTLDALREQAAALPPTL----SRTPEVQGRVPTLERHYEELQARA---GERARAL 848

Query: 1492 EVELAS-RVKAEAEAA----REKQRAL------QALEEL-----RLQAEEAERRLRQAEV 1535
            E  LA   + +EA A      EK++ L      + LE+L     R +  E E     A++
Sbjct: 849  EAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQI 908

Query: 1536 ERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQ 1595
                 +   L  A    +  + + +     +  Q  R    +  A+       +    + 
Sbjct: 909  TAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALS-IQNYHLEC 967

Query: 1596 AEAERAREEAERELERWQLKANE-ALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
             E +    E  + +E  Q   N+ A  L LQ +    ++ L    A   +   E  A   
Sbjct: 968  TETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELTREANALAA 1027

Query: 1655 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE----QELIRLRAETEQ--GEQQRQ 1708
            G   +       L E +   +   A    ++    E    Q+ +R   + +   G  Q  
Sbjct: 1028 GHPAQAVAINARLREVQTGWEDLRATMRRREESLGEARRLQDFLRSLDDFQAWLGRTQTA 1087

Query: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS----K 1764
            +  EE      EA A   +   L  E+ + ++E   L   +A  EE +R  ++      +
Sbjct: 1088 VASEEGPATLPEAEALLAQHAALRGEVERAQSEYSRL---RALGEEVTRDQADPQCLFLR 1144

Query: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE----EDAARQRAEAERVLAEKLAAI 1820
            QRLEA    + EL               RQ +LA+    +   R   +AE VL+ +   +
Sbjct: 1145 QRLEALGTGWEELGRMWE---------SRQGRLAQAHGFQGFLRDARQAEGVLSSQEYVL 1195

Query: 1821 GEATRLKT--EAEIALKEKE-------AENERLRRLAED--EAFQRRRLEEQAAQHKAD- 1868
                   T   A+ A+K+ E       A  ER+  L E   +      +     + KAD 
Sbjct: 1196 SHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIREKADS 1255

Query: 1869 IEERLAQLRKASDSELER------QKGLVEDTLRQRRQVEEEILA-----------LKAS 1911
            IE R  + + A+   L R      Q+  ++D    +  ++E++L            L   
Sbjct: 1256 IERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEARNLHTK 1315

Query: 1912 FEKAAAGKAELELE---LGRI-RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEER 1967
            ++K  A  AEL      L ++ +   E TL   E   L + + R L     RR  E E  
Sbjct: 1316 WQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEKLRDL----HRRWDELETT 1371

Query: 1968 VQKSLAAEEEAAR-----QRKAALEE-VERLKAKVEEARRLRERAEQESARQLQLAQEAA 2021
             Q    +  +A R     Q   ALE  +E L+A++            +  + L       
Sbjct: 1372 TQAKARSLFDANRAELFAQSCCALESWLESLQAQLHS---------DDYGKDLTSVNILL 1422

Query: 2022 QKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAERE 2081
            +K+   E +    AV++KE E  Q   +  +  DQ  GE E   RA EE   A  Q  RE
Sbjct: 1423 KKQQMLEWE---MAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRE 1479

Query: 2082 AAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAA 2141
              +  +   E  +  +  E+      +     E+L   +  E  +   + Q  +++ Q  
Sbjct: 1480 RCRRLQASREQHQFHRDVED------EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTL 1533

Query: 2142 DAEMEKHK-KFAEQTLRQK----AQVEQELTTLRLQLEETDHQKNLLDEELQ---RLKAE 2193
              E++ H+ + A+   RQ+    A    EL  L+   +   H+  L  + L+   R +  
Sbjct: 1534 QKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHELELRGKRLEDALRAQQF 1593

Query: 2194 ATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALI---LRDKDNTQRFLQEEAEK 2250
              +AA   + + E+   +  Q +   +L A+ E +   ++   L D   T   L   ++ 
Sbjct: 1594 YRDAAEAEAWMGEQELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQD 1653

Query: 2251 M-KQVAEEAARLSVAAQEA----ARLRQLA---EEDLAQQRALAE--KMLKEKMQAVQEA 2300
            M      E+ R+S+   +     A L++LA    E L +   L +  + L +  Q +QE 
Sbjct: 1654 MIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQER 1713

Query: 2301 TRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLAEETQGFQRTL----EAERQRQL 2354
              + A  EL Q  +   + +++ R    D   + Q+  +        L     A R    
Sbjct: 1714 EVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVA 1773

Query: 2355 EMSAEAERLKLRVAEM--SRAQA-RAEEDAQRF----RKQAEEIGEKLHRTELATQEKVT 2407
            E           + E+  +R Q   A  + QRF    R+    +  K  +    T   + 
Sbjct: 1774 EWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLN 1833

Query: 2408 LVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE----MQTVQQ--EQ 2461
              + L+ +    +HD + L   + +++ +  +LQ+       K+EE    MQ V +   Q
Sbjct: 1834 AAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQ 1891

Query: 2462 LLQETQALQQSFLSEKDSL----LQRERFIEQEKAKLEQLFQD---EVAKAQQLREEQQR 2514
            L   + A +Q  L   D        RE  +  ++  L+   Q+   +V+ A  + + QQ 
Sbjct: 1892 LQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQG 1951

Query: 2515 QQQQMEQERQRLVASME---EARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQR 2571
             + ++E    R  + ++   E   R H A E +    E+L QL+ +R++  E   E+   
Sbjct: 1952 IKAEIEARADRFSSCIDMGKELLARSHYAAEEI---SEKLSQLQARRQETAEKWQEKMDW 2008

Query: 2572 LREQLQLLEEQHRAALAHS 2590
            L+  L++L     A +A +
Sbjct: 2009 LQLVLEVLVFGRDAGMAEA 2027



 Score =  115 bits (288), Expect = 1e-24
 Identities = 318/1545 (20%), Positives = 589/1545 (38%), Gaps = 255/1545 (16%)

Query: 1126 ALRDELRGA----QEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELE 1181
            ALR E+ G     +   E+ QQ   E      +   R A+L  +W+ + A  + R + L 
Sbjct: 685  ALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEERAQRLA 744

Query: 1182 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQL-RQEQALLEEIERHG 1240
            Q    L  ++  A+ + AWL DA R    + +  L   +   + L RQ +AL EEI  H 
Sbjct: 745  QAA-SLYQFQADANDMEAWLVDALRL---VSSPELGHDEFSTQALARQHRALEEEIRSHR 800

Query: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
              ++  +  A                  A L P  S  + P+VQ    ++ + Y +L+  
Sbjct: 801  PTLDALREQA------------------AALPPTLS--RTPEVQGRVPTLERHYEELQAR 840

Query: 1301 YSELTTLTSQYIKFISETLRR------MEEEER----LAEQQRAEERERLAEVEAALEKQ 1350
              E        +   +           +EE+E+    LA  +R E+ E + +    LE +
Sbjct: 841  AGERARALEAALALYTMLSEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPE 900

Query: 1351 RQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SE 1408
                 A   A      +  +     ++ +V  +E      QQ R + +  +    S  S 
Sbjct: 901  MNTLAAQITAVNDIAEQLLKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSI 960

Query: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLE---ATERQRGGAEGELQALRARAEEAEA 1465
                 +  + +A  R + ++ E  + +   L    A +R+  G E +L+A+ AR  E   
Sbjct: 961  QNYHLECTETQAWMREKTKVIESTQGLGNDLAGVLALQRKLAGTERDLEAIAARVGELT- 1019

Query: 1466 QKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA-LEELRLQAE 1524
                                   R+A   LA+   A+A A   + R +Q   E+LR    
Sbjct: 1020 -----------------------REANA-LAAGHPAQAVAINARLREVQTGWEDLR---- 1051

Query: 1525 EAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQL 1584
             A  R R+  +  AR++Q  L +     + +    R   A  + +   +L E    +AQ 
Sbjct: 1052 -ATMRRREESLGEARRLQDFLRSLD---DFQAWLGRTQTAVASEEGPATLPEAEALLAQ- 1106

Query: 1585 REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQK 1644
                   A  + E ERA+ E  R              LR   EEV + ++  Q    +Q+
Sbjct: 1107 ------HAALRGEVERAQSEYSR--------------LRALGEEVTRDQADPQCLFLRQR 1146

Query: 1645 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
             EA       G   E+  R  E       +Q +LA+    Q    +      +AE     
Sbjct: 1147 LEA------LGTGWEELGRMWE------SRQGRLAQAHGFQGFLRDAR----QAEGVLSS 1190

Query: 1705 QQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1764
            Q+  L   E+    + A AA +K ++  + +      +  LL +  +   E    ++K +
Sbjct: 1191 QEYVLSHTEMPGTLQAADAAIKKLEDFMSTMDANGERIHGLLEAGRQLVSEGNIHADKIR 1250

Query: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEAT 1824
            ++ ++   R ++  + A +      + + Q+   ++    +    E++L  +  +  EA 
Sbjct: 1251 EKADSIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLTAQDVSYDEAR 1310

Query: 1825 RLKTE---AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
             L T+    +  + E  A  + L ++ ++     R L  +  + KA + E+L  L +  D
Sbjct: 1311 NLHTKWQKHQAFMAELAANKDWLDKVDKEG----RELTLEKPELKALVSEKLRDLHRRWD 1366

Query: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKE 1941
             ELE        T  + R + +   A +A     +    E  LE  + + +++D  +   
Sbjct: 1367 -ELETT------TQAKARSLFD---ANRAELFAQSCCALESWLESLQAQLHSDDYGKDLT 1416

Query: 1942 QAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR 2001
               +   +Q+ L  E   R +E E     ++ A+ +A  Q      EVER    VEE  R
Sbjct: 1417 SVNILLKKQQMLEWEMAVREKEVE-----AIQAQAKALAQEDQGAGEVERTSRAVEEKFR 1471

Query: 2002 LRERAEQESARQLQLAQEAAQKRLQAEEKA--------------------HAFAVQQKEQ 2041
               +  +E  R+LQ ++E  Q     E++                         + +K Q
Sbjct: 1472 ALCQPMRERCRRLQASREQHQFHRDVEDEILWVTERLPMASSMEHGKDLPSVQLLMKKNQ 1531

Query: 2042 ELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
             LQ+ +Q  +  +  LR    A   AA   E A +Q        +R   E E   +  E+
Sbjct: 1532 TLQKEIQGHEPRIADLRERQRALGAAAAGPELAELQE-----MWKRLGHELELRGKRLED 1586

Query: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQ 2161
              +A+   + AAE      EQE     Q +    + + +A AE++KH+   EQ L   AQ
Sbjct: 1587 ALRAQQFYRDAAEAEAWMGEQELHMMGQEKA---KDELSAQAEVKKHQVL-EQALADYAQ 1642

Query: 2162 VEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATEAA---RQRSQVEEELFSVRVQ 2214
               +L      + + +H ++    +   ++ +L A   E A   R+R Q    L  +R +
Sbjct: 1643 TIHQLAASSQDMIDHEHPESTRISIRQAQVDKLYAGLKELAGERRERLQEHLRLCQLRRE 1702

Query: 2215 MEELSKL--KARIEAENRAL--------ILRDK-----DNTQRFLQEEAEKMKQVAE--- 2256
            +++L +   +  + A +  L        +LRDK      +T    QE  +    +A    
Sbjct: 1703 LDDLEQWIQEREVVAASHELGQDYEHVTMLRDKFREFSRDTSTIGQERVDSANALANGLI 1762

Query: 2257 ---EAARLSVA--------------------AQEAARLRQLAEEDLAQQRALAEKMLKEK 2293
                AAR +VA                     Q  A   +L       ++ALA   ++ K
Sbjct: 1763 AGGHAARATVAEWKDSLNEAWADLLELLDTRGQVLAAAYELQRFLHGARQALAR--VQHK 1820

Query: 2294 MQAVQEATRLKAEAELLQQQKELAQE--------QARRLQEDKEQMAQQLA---EETQGF 2342
             Q + + T     A    Q++  A E        Q +++Q+D  ++ +  A    E  G 
Sbjct: 1821 QQQLPDGTGRDLNAAEALQRRHCAYEHDIQALSPQVQQVQDDGHRLQKAYAGDKAEEIGR 1880

Query: 2343 QRTLEAERQRQLEMSAEAER-LKLRVAEMSRAQARAEE-----DAQRFRKQAEEIGEKLH 2396
                 AE   QL+ S+ A R L L   +  R      E     D    +  A+E    + 
Sbjct: 1881 HMQAVAEAWAQLQGSSAARRQLLLDTTDKFRFFKAVRELMLWMDEVNLQMDAQERPRDVS 1940

Query: 2397 RTELATQEKVTLVQTLEIQRQQ--------------SDHDAERLREAIAELEREKEKLQQ 2442
              +L  + +  +   +E +  +              S + AE + E +++L+  +   Q+
Sbjct: 1941 SADLVIKNQQGIKAEIEARADRFSSCIDMGKELLARSHYAAEEISEKLSQLQARR---QE 1997

Query: 2443 EAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERF---IEQEKA--KLEQL 2497
             A+  Q K + +Q V +  +      + +++L  ++ L++       +++ ++  K  + 
Sbjct: 1998 TAEKWQEKMDWLQLVLEVLVFGRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEA 2057

Query: 2498 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
            FQ      ++     ++     E+E++R     EE RR+Q  A E
Sbjct: 2058 FQKSAVAWEERFCALEKLTALEEREKERKRKREEEERRKQPPAPE 2102



 Score =  108 bits (270), Expect = 1e-22
 Identities = 320/1501 (21%), Positives = 539/1501 (35%), Gaps = 266/1501 (17%)

Query: 1283 VQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAE 1342
            V    E  I  YV    HY       +   K I + L    E ERL E+  +   E L  
Sbjct: 261  VDQPDEKSIITYVATYYHYFSKMKALAVEGKRIGKVLDHAMEAERLVEKYESLASELLQW 320

Query: 1343 VEAALE--KQRQLAEAHAQAKAQ---------AEREAKELQQRMQEEVVRREEAAVDAQQ 1391
            +E  +     RQLA + +  + Q          E+  K  ++   E ++   ++ + A  
Sbjct: 321  IEQTIVTLNDRQLANSLSGVQNQLQSFNSYRTVEKPPKFTEKGNLEVLLFTIQSKLRANN 380

Query: 1392 QK-------RSI---------------------------QEELQQLRQSSEAEIQAKARQ 1417
            QK       R I                           QE+L+QL  ++  + +A  R+
Sbjct: 381  QKVYTPREGRLISDINKAWERLEKAEHERELALRTELIRQEKLEQL--AARFDRKAAMRE 438

Query: 1418 AEAAERSRLRIEEEIRVVRLQLEATERQRGGAE-------GELQALRARAEEAEAQKRQA 1470
               +E  RL  ++   +    +EA  R+    E       G +QA+ A A E  A++   
Sbjct: 439  TWLSENQRLVSQDNFGLELAAVEAAVRKHEAIETDIVAYSGRVQAVDAVAAELAAERYHD 498

Query: 1471 QEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL-----RLQAEE 1525
             +     +  V       RQ       R+    E  +  Q  L  ++ +     RLQ+++
Sbjct: 499  IKRIAARQHNVARLWDFLRQMVAARRERLLLNLELQKVFQDLLYLMDWMEEMKGRLQSQD 558

Query: 1526 AERRLRQAE----------------VERARQVQVA----------------------LET 1547
              R L   E                 ER R V  +                      +  
Sbjct: 559  LGRHLAGVEDLLQLHELVEADIAVQAERVRAVSASALRFCNPGKEYRPCDPQLVSERVAK 618

Query: 1548 AQRSAEA--ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAE------ 1599
             ++S EA  EL + R +  E++ +L R L E   A A +RE+    A      +      
Sbjct: 619  LEQSYEALCELAAARRARLEESRRLWRFLWEVGEAEAWVREQQHLLASADTGRDLTGALR 678

Query: 1600 ------RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1653
                    R E    L   +L   +  +L  +    A Q S   AE + Q E  E  A  
Sbjct: 679  LLNKHTALRGEMSGRLGPLKLTLEQGQQLVAEGHPGASQASARAAELQAQWERLEALAEE 738

Query: 1654 RGKAEEQAV------------------RQRELAEQELEKQRQLAEGTAQQRLAAEQELIR 1695
            R +   QA                     R ++  EL       +  A+Q  A E+E+  
Sbjct: 739  RAQRLAQAASLYQFQADANDMEAWLVDALRLVSSPELGHDEFSTQALARQHRALEEEIRS 798

Query: 1696 LRAETEQGEQQRQLLEEELAR---LQREAAAATQKRQELEAELAKVRAEMEVLLASKARA 1752
             R   +   +Q   L   L+R   +Q       +  +EL+A   +    +E  LA     
Sbjct: 799  HRPTLDALREQAAALPPTLSRTPEVQGRVPTLERHYEELQARAGERARALEAALALYTML 858

Query: 1753 EE---------------------ESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEE- 1790
             E                     E     E  +QR E        LA +   +  +AE+ 
Sbjct: 859  SEAGACGLWVEEKEQWLNGLALPERLEDLEVVQQRFETLEPEMNTLAAQITAVNDIAEQL 918

Query: 1791 -----AKRQRQLAEEDAARQRAEAERVLAE-KLAAIGEATRLK------TEAEIALKEKE 1838
                   + R +  ++    R +  R LA+ K AA+  A  ++      TE +  ++EK 
Sbjct: 919  LKANPPGKDRIVNTQEQLNHRWQQFRRLADGKKAALTSALSIQNYHLECTETQAWMREKT 978

Query: 1839 AENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQ-KGLVEDTLRQ 1897
               E  + L  D A         A Q K    ER  +   A   EL R+   L      Q
Sbjct: 979  KVIESTQGLGNDLA------GVLALQRKLAGTERDLEAIAARVGELTREANALAAGHPAQ 1032

Query: 1898 RRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE 1957
               +   +  ++  +E   A     E  LG  R   +D LRS +  +    R +   A E
Sbjct: 1033 AVAINARLREVQTGWEDLRATMRRREESLGEAR-RLQDFLRSLDDFQAWLGRTQTAVASE 1091

Query: 1958 E--RRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARR---------LRERA 2006
            E      EAE  + +  A   E  R    A  E  RL+A  EE  R         LR+R 
Sbjct: 1092 EGPATLPEAEALLAQHAALRGEVER----AQSEYSRLRALGEEVTRDQADPQCLFLRQRL 1147

Query: 2007 EQESARQLQLAQ--EAAQKRLQAEEKAHAF-AVQQKEQELQQTLQQEQSVLD--QLRGEA 2061
            E       +L +  E+ Q RL    +AH F    +  ++ +  L  ++ VL   ++ G  
Sbjct: 1148 EALGTGWEELGRMWESRQGRL---AQAHGFQGFLRDARQAEGVLSSQEYVLSHTEMPGTL 1204

Query: 2062 EAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAE 2121
            +AA  A ++ E+     +             ER+    E   Q  ++    A+K+R++A+
Sbjct: 1205 QAADAAIKKLEDFMSTMD----------ANGERIHGLLEAGRQLVSEGNIHADKIREKAD 1254

Query: 2122 QEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN 2181
                RR +  Q A +Q      +  + + F +     K  +++++ T   Q    D  +N
Sbjct: 1255 -SIERRHKKNQDAAQQFLGRLRDNREQQHFLQDCHELKLWIDEKMLT--AQDVSYDEARN 1311

Query: 2182 LLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQ 2241
             L  + Q+ +A   E A  +  +++     R    E  +LKA +  +     LRD     
Sbjct: 1312 -LHTKWQKHQAFMAELAANKDWLDKVDKEGRELTLEKPELKALVSEK-----LRDLHRRW 1365

Query: 2242 RFLQEEAEKMKQVAEEAARLSVAAQEAARLR--------QLAEEDLAQQRALAEKMLKEK 2293
              L+   +   +   +A R  + AQ    L         QL  +D  +       +LK++
Sbjct: 1366 DELETTTQAKARSLFDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQ 1425

Query: 2294 MQAVQEATRLKAEAELLQ-QQKELAQE-----QARRLQEDKEQMAQQLAEETQGFQRTLE 2347
                 E    + E E +Q Q K LAQE     +  R     E+  + L +  +   R L+
Sbjct: 1426 QMLEWEMAVREKEVEAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQ 1485

Query: 2348 AERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2407
            A R+ Q +   + E   L V E     +  E             G+ L   +L  ++  T
Sbjct: 1486 ASRE-QHQFHRDVEDEILWVTERLPMASSMEH------------GKDLPSVQLLMKKNQT 1532

Query: 2408 LVQTL--------EIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQ 2459
            L + +        +++ +Q    A      +AEL+   ++L  E   L+L+ + ++   +
Sbjct: 1533 LQKEIQGHEPRIADLRERQRALGAAAAGPELAELQEMWKRLGHE---LELRGKRLEDALR 1589

Query: 2460 EQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQM 2519
             Q      A  ++++ E     Q    + QEKAK E   Q EV K Q L +      Q +
Sbjct: 1590 AQQFYRDAAEAEAWMGE-----QELHMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTI 1644

Query: 2520 EQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLL 2579
             Q    L AS ++    +H     +  +Q ++ +L    +   EL  E  +RL+E L+L 
Sbjct: 1645 HQ----LAASSQDMIDHEHPESTRISIRQAQVDKLYAGLK---ELAGERRERLQEHLRLC 1697

Query: 2580 E 2580
            +
Sbjct: 1698 Q 1698



 Score = 77.4 bits (189), Expect = 3e-13
 Identities = 246/1127 (21%), Positives = 449/1127 (39%), Gaps = 176/1127 (15%)

Query: 951  EQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPAR--ECAQRIAEQQKAQ 1008
            E+   E  R Q  +  L D +  L   +T          ++ PA   E    +A+    +
Sbjct: 1058 EESLGEARRLQDFLRSLDDFQAWLGRTQTAVAS------EEGPATLPEAEALLAQHAALR 1111

Query: 1009 AEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELT------LGKLEQVRSLSAIY 1062
             EVE      +RL A  E+V    +  P    LR  LE        LG++ + R      
Sbjct: 1112 GEVERAQSEYSRLRALGEEVTR-DQADPQCLFLRQRLEALGTGWEELGRMWESRQGR--- 1167

Query: 1063 LEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQP 1122
            L +       +R  + AE VL + E  L   + +P TL   +A  A++KKL    E    
Sbjct: 1168 LAQAHGFQGFLRDARQAEGVLSSQEYVLSHTE-MPGTL---QAADAAIKKL----EDFMS 1219

Query: 1123 TFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQ 1182
            T DA  + + G  E G +L     E ++  ++ RE+   +  R +      D  Q+ L +
Sbjct: 1220 TMDANGERIHGLLEAGRQLVS---EGNIHADKIREKADSIERRHKK---NQDAAQQFLGR 1273

Query: 1183 L--GRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHG 1240
            L   R+ +++ +    L  W+ +   +    Q +   +++ +  + ++ QA + E+  + 
Sbjct: 1274 LRDNREQQHFLQDCHELKLWIDE---KMLTAQDVSYDEARNLHTKWQKHQAFMAELAAN- 1329

Query: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKP------KVQSGSESVIQEY 1294
                      K +++ +     +L   K +L+ + S   +       ++++ +++  +  
Sbjct: 1330 ----------KDWLDKVDKEGRELTLEKPELKALVSEKLRDLHRRWDELETTTQAKARSL 1379

Query: 1295 VDLRTH--YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQR 1351
             D      +++       +++ +   L   +  + L       +++++ E E A+ EK+ 
Sbjct: 1380 FDANRAELFAQSCCALESWLESLQAQLHSDDYGKDLTSVNILLKKQQMLEWEMAVREKEV 1439

Query: 1352 QLAEAHAQAKAQAEREAKELQQRMQ-------------EEVVRREEAAVDAQQQKRSIQE 1398
            +  +A A+A AQ ++ A E+++  +              E  RR +A+ +  Q  R +++
Sbjct: 1440 EAIQAQAKALAQEDQGAGEVERTSRAVEEKFRALCQPMRERCRRLQASREQHQFHRDVED 1499

Query: 1399 EL----QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL-EATERQRGGAEGEL 1453
            E+    ++L  +S  E        +   +    +++EI+    ++ +  ERQR      L
Sbjct: 1500 EILWVTERLPMASSMEHGKDLPSVQLLMKKNQTLQKEIQGHEPRIADLRERQRA-----L 1554

Query: 1454 QALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQA-EVELASRVKAEAEAAREKQRA 1512
             A  A  E AE Q     E  +RL  +++   +R   A   +   R  AEAEA   +Q  
Sbjct: 1555 GAAAAGPELAELQ-----EMWKRLGHELELRGKRLEDALRAQQFYRDAAEAEAWMGEQEL 1609

Query: 1513 L-----QALEELRLQAEEAERR-LRQAEVERARQVQVALETAQRSAEAEL-QSKRASFAE 1565
                  +A +EL  QAE  + + L QA  + A+ +     ++Q   + E  +S R S  +
Sbjct: 1610 HMMGQEKAKDELSAQAEVKKHQVLEQALADYAQTIHQLAASSQDMIDHEHPESTRISIRQ 1669

Query: 1566 -----------KTAQLERSLQEEHVAVAQLREEAERRAQ--QQAEAERAREEAERELERW 1612
                       + A   R   +EH+ + QLR E +   Q  Q+ E   A  E  ++ E  
Sbjct: 1670 AQVDKLYAGLKELAGERRERLQEHLRLCQLRRELDDLEQWIQEREVVAASHELGQDYEHV 1729

Query: 1613 QLKANEALRLRLQAEEVAQQK-----SLAQ-------------AEAEKQKEEAEREARR- 1653
             +  ++          + Q++     +LA              AE +    EA  +    
Sbjct: 1730 TMLRDKFREFSRDTSTIGQERVDSANALANGLIAGGHAARATVAEWKDSLNEAWADLLEL 1789

Query: 1654 ---RGKAEEQAVR-QREL--AEQEL----EKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
               RG+    A   QR L  A Q L     KQ+QL +GT +   AAE  L R     E  
Sbjct: 1790 LDTRGQVLAAAYELQRFLHGARQALARVQHKQQQLPDGTGRDLNAAEA-LQRRHCAYEHD 1848

Query: 1704 EQ----QRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRST 1759
             Q    Q Q ++++  RLQ+  A A  K +E+   +  V      L  S A   +    T
Sbjct: 1849 IQALSPQVQQVQDDGHRLQK--AYAGDKAEEIGRHMQAVAEAWAQLQGSSAARRQLLLDT 1906

Query: 1760 SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAA 1819
            ++K +     +A R   L  +   L+  A+E  R    A+     Q+     + A    A
Sbjct: 1907 TDKFRF---FKAVRELMLWMDEVNLQMDAQERPRDVSSADLVIKNQQGIKAEIEAR---A 1960

Query: 1820 IGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKAD----IEERLAQ 1875
               ++ +    E+  +   A  E   +L++ +A  RR+   +  Q K D    + E L  
Sbjct: 1961 DRFSSCIDMGKELLARSHYAAEEISEKLSQLQA--RRQETAEKWQEKMDWLQLVLEVLVF 2018

Query: 1876 LRKASDSE--LERQKGLVEDT-LRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSN 1932
             R A  +E  L  Q+ LV    L       E ++    +F+K+A    E        R  
Sbjct: 2019 GRDAGMAEAWLCSQEPLVRSAELGCTVDEVESLIKRHEAFQKSAVAWEE--------RFC 2070

Query: 1933 AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAA 1979
            A + L + E+ E           +E +R+RE EER ++  A E  A+
Sbjct: 2071 ALEKLTALEERE-----------KERKRKREEEERRKQPPAPEPTAS 2106


>gi|45439327 periplakin [Homo sapiens]
          Length = 1756

 Score =  413 bits (1062), Expect = e-114
 Identities = 426/1763 (24%), Positives = 785/1763 (44%), Gaps = 218/1763 (12%)

Query: 372  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 431
            L  ++ +LQ  A   E+ +   +A +QSD+  L  G+ P+      + +  ++ ++ +L 
Sbjct: 27   LSELIEQLQKNADQVEKNIVDTEAKMQSDLARLQEGRQPEHRDVTLQKVLDSEKLLYVLE 86

Query: 432  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 491
             D    K  +HPQG+ +   + +L ER+  +R ++             Q+ ++ ++ V  
Sbjct: 87   ADAAIAKHMKHPQGDMIAEDIRQLKERVTNLRGKHK------------QIYRLAVKEVD- 133

Query: 492  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 551
             P++  + L         VEE   +++   +G DLP V+ Q+  H   H  ++     + 
Sbjct: 134  -PQVNWAAL---------VEEKLDKLNNQSFGTDLPLVDHQVEEHNIFHNEVKAIGPHLA 183

Query: 552  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 611
            +    E                 L  +Y KLL +S+AR + L SL  ++   T EL WL+
Sbjct: 184  KDGDKEQN-------------SELRAKYQKLLAASQARQQHLSSLQDYMQRCTNELYWLD 230

Query: 612  EKEEEEVGFDWSDRNTNMTAKKESYSALM-RELELKEKKIKELQNAGDRLLREDHPARPT 670
            ++ +  + +DWSDRN +  +++  Y   + R LE KE++I +L + GD+LL  +HP R +
Sbjct: 231  QQAKGRMQYDWSDRNLDYPSRRRQYENFINRNLEAKEERINKLHSEGDQLLAAEHPGRNS 290

Query: 671  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 730
            +E+   A+   W   L L  C E+HLK    Y QF  DV++A+  L+K+   L +KY  D
Sbjct: 291  IEAHMEAVHADWKEYLNLLICEESHLKYMEDYHQFHEDVKDAQELLRKVDSDLNQKYGPD 350

Query: 731  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 790
                  ++E LL++  D+++ L++Y+  + GL KR + VV LK R    P++  +P+ A+
Sbjct: 351  FKDRY-QIELLLRELDDQEKVLDKYEDVVQGLQKRGQQVVPLKYRRET-PLKP-IPVEAL 407

Query: 791  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 850
            CD++  +  + +G    L      S W+++ S+G++   P+VCF++PP            
Sbjct: 408  CDFEGEQGLISRGYSYTLQKNNGES-WELMDSAGNKLIAPAVCFVIPP------------ 454

Query: 851  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 910
                            D ++L    SL    + +R  +  + RTL   +QR  +   E  
Sbjct: 455  ---------------TDPEALALADSLGSQYRSVRQKAAGSKRTL---QQRYEVLKTENP 496

Query: 911  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 970
                  D+ D  G                    +QLL  L++ A +  R ++ I+ +   
Sbjct: 497  -----GDASDLQG--------------------RQLLAGLDKVASDLDRQEKAITGI--- 528

Query: 971  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1029
                          LR PL++  A ++ A+R  + +    E+  +     R +AE E  +
Sbjct: 529  --------------LRPPLEQGRAVQDSAERAKDLKNITNELLRIEPEKTRSTAEGEAFI 574

Query: 1030 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQ 1089
                 S   P LR+ +E T  K E +  L  +  EK+   + + +  Q + E+L  HE  
Sbjct: 575  QALPGSGTTPLLRTRVEDTNRKYEHLLQLLDLAQEKVDVANRLEKSLQQSWELLATHENH 634

Query: 1090 LKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1149
            L +   VP +   L++    L  +  + +AQ+     +   L+ A++    L  R  E  
Sbjct: 635  LNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAAKQCSSTLASRFQEHC 694

Query: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1209
             ++ER    V +L +R+  +  Q + R + L+       ++    D +  +L      + 
Sbjct: 695  PDLERQEAEVHKLGQRFNNLRQQVERRAQSLQSAKAAYEHFHRGHDHVLQFLVSIPSYEP 754

Query: 1210 QIQAMPLADSQAVRE-QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1268
            Q       DS +  E +L+ ++ LL+EI    ++V++    ++QY  A+KDYEL+    +
Sbjct: 755  Q-----ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLR 809

Query: 1269 AQLE----PVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1324
            + L+      +  +K+ ++QS +  V +E   L   ++E+  +  Q ++ +   L  + +
Sbjct: 810  SLLDLENGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQ 869

Query: 1325 EERLAEQQRAEERERL-AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRM-------- 1375
            +  +       +R R  + VE A + +++L E   + + Q E E K  Q+ +        
Sbjct: 870  QPEVEVTHETLQRNRPDSGVEEAWKIRKELDE-ETERRRQLENEVKSTQEEIWTLRNQGP 928

Query: 1376 QEEVVRRE------------------EAAVDAQQQKRSIQEELQQLR-QSSEAEIQAKAR 1416
            QE VVR+E                      + Q + + +QEEL+ L+ Q    E + +  
Sbjct: 929  QESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDG 988

Query: 1417 QAEAAERSRLRIE------EEIRVVRLQLEATERQRGGAEGELQALRARA-----EEAEA 1465
              E   +  LRIE      +E+  +R +LEA  RQ+G  E E+  L+ R      E++ A
Sbjct: 989  GQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQRVAALAEEKSRA 1048

Query: 1466 QKRQAQEEAERLRRQVQDES-----QRKRQAEVELASRVKAEAEAAREKQRALQALEELR 1520
            Q++  ++E  +L+   Q E+     Q   Q + +L  + + E    ++K   L+ LE+ R
Sbjct: 1049 QEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK---LKRLEKER 1105

Query: 1521 LQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--SLQEEH 1578
              AE         +VE+    +  +    R  E E    RAS  EKT  L +  +L+EE+
Sbjct: 1106 AMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKTELLRKIWALEEEN 1165

Query: 1579 VAVA---QLRE----------EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQ 1625
              V    ++RE          E      +  E ER    AE +L  +Q +  EALR R  
Sbjct: 1166 AKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQSEL-EALRRRGP 1224

Query: 1626 AEEVAQ-QKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQ 1684
              EV +  K + + + + + E+  +  R     + + + + +L   +L+K+ Q  + T  
Sbjct: 1225 QVEVKEVTKEVIKYKTDPEMEKELQRLREEIVDKTRLIERCDLEIYQLKKEIQALKDTKP 1284

Query: 1685 QRLAAE--QELIRLRAETEQGEQ----QRQLLEEELARLQREAAAATQKRQELEAELAKV 1738
            Q    E  QE+++ + + +  E+    + +L EE+  ++  E   A+Q+ Q    E    
Sbjct: 1285 QVQTKEVVQEILQFQEDPQTKEEVASLRAKLSEEQKKQVDLERERASQEEQIARKEEELS 1344

Query: 1739 RAEMEVLLASKARAEEESRSTSEKS--KQRLEAEAGRFRELAEEAARLRALAEEAKRQ-R 1795
            R +  V+     R EEE    +E S   + ++ E  +  +L  E  RL+    E +RQ  
Sbjct: 1345 RVKERVVQQEVVRYEEEPGLRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404

Query: 1796 QLAEEDAARQRAEAE-RVLAEKLAAI----GEATRLKTEAEIALKEKEAENER---LRRL 1847
            +L  E  AR+ AE E + L ++LAA+     EA    T  +  + +++ +  R   L RL
Sbjct: 1405 ELERERQARREAEREVQRLQQRLAALEQEEAEAREKVTHTQKVVLQQDPQQAREHALLRL 1464

Query: 1848 AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILA 1907
              +E   RR+L E   +    +  +LA L KA   E++ +  L E    ++   E+EI  
Sbjct: 1465 QLEEEQHRRQLLEGELE---TLRRKLAALEKA---EVKEKVVLSESVQVEKGDTEQEIQR 1518

Query: 1908 LKASFEKAAAGKAELELELGRIRSNAEDT--LRSKEQAELEAARQRQLAAEEERRRREAE 1965
            LK+S E+ +  K EL++E+ R+ +   +     SK   EL+  R+     + ER+  + E
Sbjct: 1519 LKSSLEEESRSKRELDVEVSRLEARLSELEFHNSKSSKELDFLREENHKLQLERQNLQLE 1578

Query: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRE-RAEQESARQLQLAQEAAQKR 2024
             R    L +E   A      L  +    +      RL     E +  ++L   ++     
Sbjct: 1579 TR---RLQSEINMAATETRDLRNMTVADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDE 1635

Query: 2025 LQAEEKAHAFAVQQKEQELQQTL 2047
            LQ    + A   +Q+E  L++++
Sbjct: 1636 LQKRLGSVAVKREQRENHLRRSI 1658



 Score =  187 bits (476), Expect = 2e-46
 Identities = 338/1485 (22%), Positives = 609/1485 (41%), Gaps = 254/1485 (17%)

Query: 1346 ALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQ 1405
            AL     L   +   + +A    + LQQR   EV++ E     +  Q R +   L ++  
Sbjct: 459  ALALADSLGSQYRSVRQKAAGSKRTLQQRY--EVLKTENPGDASDLQGRQLLAGLDKV-- 514

Query: 1406 SSEAEIQAKA---------RQAEAAERSRLRIEEEIRVVR--LQLEATERQRGGAEGELQ 1454
            +S+ + Q KA          Q  A + S  R ++   +    L++E  E+ R  AEGE  
Sbjct: 515  ASDLDRQEKAITGILRPPLEQGRAVQDSAERAKDLKNITNELLRIEP-EKTRSTAEGE-- 571

Query: 1455 ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
                    A  Q          LR +V+D + RK +  ++L    + + + A   +++LQ
Sbjct: 572  --------AFIQALPGSGTTPLLRTRVED-TNRKYEHLLQLLDLAQEKVDVANRLEKSLQ 622

Query: 1515 ALEELRLQAEEAERRLRQAE-VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERS 1573
               EL       E  L Q + V  + +V  +      +   ELQ++++   E    L+ +
Sbjct: 623  QSWEL---LATHENHLNQDDTVPESSRVLDSKGQELAAMACELQAQKSLLGEVEQNLQAA 679

Query: 1574 LQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQK 1633
             Q      ++ +E      +Q+AE  +  +                  LR Q E  AQ  
Sbjct: 680  KQCSSTLASRFQEHCPDLERQEAEVHKLGQRFNN--------------LRQQVERRAQSL 725

Query: 1634 SLAQAEAE---KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAE 1690
              A+A  E   +  +   +        E Q        E +L+ Q+ L +  A +    E
Sbjct: 726  QSAKAAYEHFHRGHDHVLQFLVSIPSYEPQETDSLSQMETKLKNQKNLLDEIASR----E 781

Query: 1691 QELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKA 1750
            QE+ ++ A ++Q +Q                     K  ELEAE  +   ++E   +S  
Sbjct: 782  QEVQKICANSQQYQQ-------------------AVKDYELEAEKLRSLLDLENGRSSHV 822

Query: 1751 RAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
                  +S + K K+   A A +F E+ A    RL+ L       RQ  E +   +  + 
Sbjct: 823  SKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEVTHETLQR 882

Query: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADI 1869
             R      + + EA +++       KE + E ER R+L  +    +  +     Q   + 
Sbjct: 883  NR----PDSGVEEAWKIR-------KELDEETERRRQLENEVKSTQEEIWTLRNQGPQES 931

Query: 1870 EERLAQLRKASDSELERQKGLVEDTLRQRRQ----VEEEILALKASF-----EKAAAGKA 1920
              R   L+K  D  LE     ++ TL + +     ++EE+ AL+        E    G+ 
Sbjct: 932  VVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQLRALEQETRDGGQE 991

Query: 1921 ELELELGRI---RSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE 1977
             +  E+ RI   R+ A++ L+ +E  ELEA R+++ A E                 AE  
Sbjct: 992  YVVKEVLRIEPDRAQADEVLQLRE--ELEALRRQKGARE-----------------AEVL 1032

Query: 1978 AARQRKAAL-EEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2036
              +QR AAL EE  R + KV E   ++ + + +   + Q  QE  Q++ Q  EK      
Sbjct: 1033 LLQQRVAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK------ 1086

Query: 2037 QQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE-EARVQAEREAAQSRRQVE-EAER 2094
              +E+EL   LQ +   L++ R  AE      E  + E     ERE +   RQ E EA +
Sbjct: 1087 --QEEELS-FLQDKLKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAK 1143

Query: 2095 LKQSAEEQAQARAQAQAAAEKLRKEAEQEAAR-------RAQAEQAALRQK--------Q 2139
             + S  E+ +   +  A  E+  K   QE  R       +A++E A LR +        +
Sbjct: 1144 ARASQREKTELLRKIWALEEENAKVVVQEKVREIVRPDPKAESEVANLRLELVEQERKYR 1203

Query: 2140 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAAR 2199
             A+ ++  ++   E   R+  QVE +  T  +   +TD +   +++ELQRL+ E  +  R
Sbjct: 1204 GAEEQLRSYQSELEALRRRGPQVEVKEVTKEVIKYKTDPE---MEKELQRLREEIVDKTR 1260

Query: 2200 QRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAA 2259
               + + E++ ++ +++ L   K +++          K+  Q  LQ + +   Q  EE A
Sbjct: 1261 LIERCDLEIYQLKKEIQALKDTKPQVQT---------KEVVQEILQFQEDP--QTKEEVA 1309

Query: 2260 RLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE 2319
             L     E     Q  + DL ++RA  E+ +  K            E EL + ++ + Q+
Sbjct: 1310 SLRAKLSE----EQKKQVDLERERASQEEQIARK------------EEELSRVKERVVQQ 1353

Query: 2320 QARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEE 2379
            +  R +E+       L  E   F  +++ E ++  ++ AE  RL+ R  E+ R     E 
Sbjct: 1354 EVVRYEEEPG-----LRAEASAFAESIDVELRQIDKLRAELRRLQRRRTELERQLEELER 1408

Query: 2380 DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2439
            + Q                                 R++++ + +RL++ +A LE+E+ +
Sbjct: 1409 ERQA--------------------------------RREAEREVQRLQQRLAALEQEEAE 1436

Query: 2440 LQQEAKLLQ--LKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQL 2497
             +++    Q  +  ++ Q  ++  LL+    LQ      +  LL+ E  +E  + KL  L
Sbjct: 1437 AREKVTHTQKVVLQQDPQQAREHALLR----LQLEEEQHRRQLLEGE--LETLRRKLAAL 1490

Query: 2498 FQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLE-- 2555
             + EV +   L E  Q ++   EQE QRL +S+EE  R + E +  V R +  L +LE  
Sbjct: 1491 EKAEVKEKVVLSESVQVEKGDTEQEIQRLKSSLEEESRSKRELDVEVSRLEARLSELEFH 1550

Query: 2556 -QQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGP 2614
              +  ++ + L EEN +L+ + Q L+ + R   +         +AAT+T    RD  +  
Sbjct: 1551 NSKSSKELDFLREENHKLQLERQNLQLETRRLQSE------INMAATET----RDLRNMT 1600

Query: 2615 AAEAEPEHS--FDGLRRKV-SAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQ 2671
             A++   H      L R++   +RL +   L  +ELQ+   G   V    +RE   ++L 
Sbjct: 1601 VADSGTNHDSRLWSLERELDDLKRLSKDKDLEIDELQK-RLGSVAV----KREQRENHL- 1654

Query: 2672 GRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQ-------------AASGFLL 2718
             R SI  ++   T  +LS   A  R  L      + L +Q               S  + 
Sbjct: 1655 -RRSIV-VIHPDTGRELSPEEA-HRAGLIDWNMFVKLRSQECDWEEISVKGPNGESSVIH 1711

Query: 2719 DPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQ 2763
            D    ++ ++ EA++ G + P  + + ++ + ++       +GQ+
Sbjct: 1712 DRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSGQK 1756



 Score = 85.1 bits (209), Expect = 1e-15
 Identities = 40/110 (36%), Positives = 71/110 (64%), Gaps = 1/110 (0%)

Query: 4107 KTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEEITISSSDG 4166
            K   + +  +R +V++ P+TG+E+S  EA+R GLID   +++L  QEC+WEEI++   +G
Sbjct: 1646 KREQRENHLRRSIVVIHPDTGRELSPEEAHRAGLIDWNMFVKLRSQECDWEEISVKGPNG 1705

Query: 4167 VVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSG 4216
               S+I DR+SG+++ I++A+    +  +  D+Y    +SI E A ++SG
Sbjct: 1706 -ESSVIHDRKSGKKFSIEEALQSGRLTPAQYDRYVNKDMSIQELAVLVSG 1754


>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
            sapiens]
          Length = 2364

 Score =  404 bits (1039), Expect = e-112
 Identities = 576/2480 (23%), Positives = 1023/2480 (41%), Gaps = 319/2480 (12%)

Query: 8    QNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP 67
            ++ I +L DER+ VQKKTFTKWVN HL +    I+DLY DLRDG  LI LLEVLSG+ LP
Sbjct: 42   RSRIKALADEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERLP 101

Query: 68   RE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 126
            +  KGRMR H L+NV  AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI D
Sbjct: 102  KPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQD 161

Query: 127  IQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184
            I V  +   E  +AK+ LLLW Q    GY  +   NFT+SWRDG  FNA+IH+H+P LID
Sbjct: 162  ISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLID 221

Query: 185  MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244
             +K+ +     NL  AF++AE+ LG+T+LLDPED+ V  PDEKSIITYV + Y    ++ 
Sbjct: 222  FDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKMK 281

Query: 245  DVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 296
             +  +G R       A E +   ++Y  L   LL+W+         R+F +S   ++   
Sbjct: 282  ALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQL 341

Query: 297  SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHV 353
              F  ++ +E P K  +K   + +  +++  ++A   KV     G    D+ K W +L  
Sbjct: 342  QAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLEK 401

Query: 354  AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVP 410
            A  ERE  LR+E  R E L+++  +   +A + E  L++   L+  D     L A     
Sbjct: 402  AEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAAT 461

Query: 411  QRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEYN 467
            ++   +E D+   +  ++ +    + L+   +   +++  R   V RL E L+ +     
Sbjct: 462  KKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRARR 521

Query: 468  LRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLP 527
             RL+  +           LQ + +        + Y+ D   W++E +  V   ++G  L 
Sbjct: 522  QRLEMNLG----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHLL 561

Query: 528  SVEAQLGSHRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA 580
             VE  L  H  +        + +    A  ++  +D     P      RD +  ++  Y 
Sbjct: 562  GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCYQ 621

Query: 581  KLLN---SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 637
            +L       +ARL     L  F     +E  W+ EKE+     D+    T++      + 
Sbjct: 622  ELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKHR 681

Query: 638  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697
            A   E+  +    ++    G+ ++ E+H     +      ++ QW+ + QL    +  L+
Sbjct: 682  AFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRLE 741

Query: 698  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 757
            E +   QF +D  + +     + + L+   S D        + L++  +D  E++  Y+ 
Sbjct: 742  EASLLHQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYRP 798

Query: 758  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT----------------V 800
             L  L ++A A+ Q     P   +RGRL  +    YK+V E+T                 
Sbjct: 799  TLDTLHEQASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKMF 855

Query: 801  HKGDECQL------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQEA 846
             + D C+L              P +    +V+       E  + +    V   NQ A++ 
Sbjct: 856  SEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQL 915

Query: 847  V-------TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLATF 892
            +         ++AQ   L T W Q    VD K     S L+ Q+   +    +SW     
Sbjct: 916  MHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREKT 975

Query: 893  RTLKPEE------------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934
            + ++  +                    + L ++E       ++++      P+       
Sbjct: 976  KVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILS 1035

Query: 935  EYGSCSHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDK 991
                 S  ++++   L++ E    E S+ Q+ + +L D +  L   +T            
Sbjct: 1036 RLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA--------- 1086

Query: 992  EPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSEL 1045
              + +    + E +K   + E +   +     + +K+  + E      T      LR  L
Sbjct: 1087 --SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRL 1144

Query: 1046 E-LTLG--KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1102
            + L  G  +L ++       L +       +R T+ AE  L   E  L   + +P T   
Sbjct: 1145 QALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT--- 1200

Query: 1103 LEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQL 1162
            LE  +A++KK     E    T DA  +++    E G RL     + ++  +R +E+V  +
Sbjct: 1201 LEGAEAAIKK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDSI 1253

Query: 1163 LERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV 1222
             +R +            L+   R L+ + +    L  W+ +   +    Q M   +++ +
Sbjct: 1254 DDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARNL 1309

Query: 1223 REQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AKK 1280
              +  + QA + E+  +           K++++ I+   +QL++ K + E V        
Sbjct: 1310 HSKWLKHQAFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTGL 1358

Query: 1281 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERL 1340
             K+    ES  Q     R   +    L +Q    + + L  +E     ++ Q  +  + L
Sbjct: 1359 HKMWEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKDL 1412

Query: 1341 AEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQE 1398
              V   L+KQ+ L       + Q E   KE+++ + Q + + +E  + D    KR ++Q 
Sbjct: 1413 TSVNILLKKQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT 1465

Query: 1399 ELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQAL 1456
            +  +L +             E  + +R  +E+EI  V  R+ L AT    G     LQ +
Sbjct: 1466 KFMELLEPLNERKHNLLASKEIHQFNR-DVEDEILWVGERMPL-ATSTDHG---HNLQTV 1520

Query: 1457 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQAL 1516
            +   ++ +  +++ Q    R    + D  +R +    + +S     AEA R++   L+ L
Sbjct: 1521 QLLIKKNQTLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQL 1573

Query: 1517 EELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQE 1576
              L +  EE E+R R+ E E  R  Q   + A+  AEA +  +     E     E   ++
Sbjct: 1574 WGLLI--EETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAKD 1623

Query: 1577 EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1636
            E  AV+ L++                +  E+ +E +             AE V Q    +
Sbjct: 1624 EQSAVSMLKK---------------HQILEQAVEDY-------------AETVHQLSKTS 1655

Query: 1637 QAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLAA 1689
            +A       E+ER + R+ K ++     ++LAE+   +L+++ +L +   +    ++  A
Sbjct: 1656 RALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIA 1715

Query: 1690 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
            E+E++    E  Q  +   +L+E      R+     Q+R +    LA      E++ +  
Sbjct: 1716 EREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSGH 1770

Query: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
            + A     +T  + K  L        EL +   ++ A + E  +    A+E   R + + 
Sbjct: 1771 SDA-----ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-DK 1824

Query: 1810 ERVLAEKLA----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH 1865
             + L E+L      +    R+ T  E    + +A   ++R+L ED A    RL+   A  
Sbjct: 1825 HKKLPEELGRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAGD 1877

Query: 1866 KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELE 1925
            KAD       ++K  +  LE  K L+ D    RR    +       F         +E  
Sbjct: 1878 KAD------DIQKRENEVLEAWKSLL-DACESRRVRLVDTGDKFRFFSMVRDLMLWMEDV 1930

Query: 1926 LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQRK 1983
            + +I   A++  R     EL     + + AE + R       ++  KSL      AR+  
Sbjct: 1931 IRQI--EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKHY 1983

Query: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043
            A+ E  E+L    E+ + + ++ E +    L+L  E  Q    A   A A+ + Q+    
Sbjct: 1984 ASEEIKEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYLS 2041

Query: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ-- 2097
             + + Q    +++L    EA  ++A   +E     ER    E  + RRQ EE ER ++  
Sbjct: 2042 SREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPP 2101

Query: 2098 SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157
            S E   +   +A++  +    + EQ +     AEQ + R  +  D               
Sbjct: 2102 SPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDT-------------- 2147

Query: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
              +++    T  R   +E+    +   +   +    A  AA   ++ +E   +   QME 
Sbjct: 2148 --SEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQE---TPSAQMEG 2202

Query: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
                K   EA N+    R   N    +  +     + A+ A         A+ +   +E 
Sbjct: 2203 FLNRKHEWEAHNKKASSRSWHNVYCVINNQEMGFYKDAKTA---------ASGIPYHSEV 2253

Query: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAE 2337
             ++ + A+ E  L  K +      RL    E L Q K+  +E    +Q     ++    E
Sbjct: 2254 PVSLKEAVCEVALDYKKKKHVFKLRLNDGNEYLFQAKD-DEEMNTWIQAISSAISSDKHE 2312

Query: 2338 ETQGFQRTLEAERQRQLEMS 2357
             +   Q T  + R + L  S
Sbjct: 2313 VSASTQSTPASSRAQTLPTS 2332



 Score =  104 bits (259), Expect = 2e-21
 Identities = 340/1836 (18%), Positives = 710/1836 (38%), Gaps = 258/1836 (14%)

Query: 958  SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1017
            S  QR +S+  +    L A E  T     +  D     E  Q +    + + E E     
Sbjct: 439  SENQRLVSQ-DNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR-ELEAENY-HD 495

Query: 1018 VARLSAEAEKVLALPE---PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI- 1073
            + R++A  + V+ L E       A   R E+ L L K+ Q       +++++K + L   
Sbjct: 496  IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQD 555

Query: 1074 --RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF-DALRDE 1130
              +   G E++L+ H   L EA  +      +    AS +K     E  +P     +RD 
Sbjct: 556  YGKHLLGVEDLLQKHT--LVEAD-IGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR 612

Query: 1131 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1190
            +   +   + L Q   ER   +E  R      L ++   +A+ +   RE E++       
Sbjct: 613  VAHMEFCYQELCQLAAERRARLEESRR-----LWKFFWEMAEEEGWIREKEKI------- 660

Query: 1191 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250
              S+D  G  L    R         L+  +A  +++       E+  + GE +   + F 
Sbjct: 661  -LSSDDYGKDLTSVMRL--------LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG 711

Query: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310
             +    I++  + +    A LE +++  KK   ++      Q   D      ++      
Sbjct: 712  SE---KIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD------DIDAWMLD 762

Query: 1311 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1370
             +K +S +    +E    + Q   ++ + +AE  A            A A  Q   E+ +
Sbjct: 763  ILKIVSSSDVGHDE---YSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPD 819

Query: 1371 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1430
            ++ R+     R +E A   + +K+++Q+ L   +  SEA+        +    + ++I E
Sbjct: 820  VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 879

Query: 1431 ---EIRVVRLQLEATERQRGGAEGELQALRARAEE-------AEAQKRQAQEEAERLRRQ 1480
               ++ V++ + E+ E +       +  +   A +       +E + +  Q++      Q
Sbjct: 880  KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 939

Query: 1481 VQDESQRKRQAEVELASRVKAEAEA------AREKQRALQALEELRLQAEEA---ERRLR 1531
             ++   RK+ A +   S      E        REK + +++ ++L          +R+L 
Sbjct: 940  FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 999

Query: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREE 1587
              E +    ++  L   Q+ AE +L+S+    A+    + A++   + EE     + RE 
Sbjct: 1000 GMERDLVA-IEAKLSDLQKEAE-KLESEHPDQAQAILSRLAEIS-DVWEEMKTTLKNREA 1056

Query: 1588 AERRAQQQAEAERAREEAERELERWQLKA---------NEALRLRLQAEEVAQQKSLAQA 1638
            +   A +  +  R  ++ +  L R Q             EA +L  Q E +  +    + 
Sbjct: 1057 SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEE 1116

Query: 1639 EAEKQKEEAEREARRRGKAEEQAVRQR---------ELAEQELEKQRQLAEGTAQQRLAA 1689
            + +K ++  E   + +  A+   +RQR         EL +    +Q  L++  A Q+   
Sbjct: 1117 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1176

Query: 1690 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
            + +    +AE     Q+  L   E+      A AA +K+++    +     ++  ++ + 
Sbjct: 1177 DTK----QAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETG 1232

Query: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
             R   +    S++ ++++++   R R+  E A+ L    ++ +  ++  ++         
Sbjct: 1233 RRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN 1292

Query: 1810 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
            E++L  +  +  EA  L ++     A   + A N+      E E  Q   L  +  + +A
Sbjct: 1293 EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ---LISEKPETEA 1349

Query: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
             ++E+L  L K            + + L    Q + + L      E      A+L+  L 
Sbjct: 1350 VVKEKLTGLHK------------MWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH 1397

Query: 1928 RIRSN--AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1985
             + S   ++D  +      +   +Q+ L  + E R++E EE     L ++ +A  Q   +
Sbjct: 1398 GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE-----LQSQAQALSQEGKS 1452

Query: 1986 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------------- 2031
             +EV+  +  V+           E    L  ++E  Q     E++               
Sbjct: 1453 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1512

Query: 2032 HAFAVQ------QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
            H   +Q      +K Q LQ+ +Q  Q  +D +    E ++    ++     +A R+    
Sbjct: 1513 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI---FERSQNIVTDSSSLSAEAIRQRLAD 1569

Query: 2086 RRQ-----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140
             +Q     +EE E+  +  EE  +A+     AAE     +EQE    ++ +    + +Q+
Sbjct: 1570 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA---KDEQS 1626

Query: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATE 2196
            A + ++KH+   EQ +   A+   +L+     L    H ++    +   ++ +L A   +
Sbjct: 1627 AVSMLKKHQ-ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1685

Query: 2197 AARQRSQVEEE---LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253
             A +R    +E   LF +  ++++L +  A  E    +  L         LQE   + ++
Sbjct: 1686 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE---RFRE 1742

Query: 2254 VAEEAARLSVAAQEAARLRQLAEE----------DLAQQRALAEKMLKEKMQAVQEATRL 2303
             A +    ++  +    +  LA+E           +A+ +    +   + ++ +   T++
Sbjct: 1743 FARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI 1800

Query: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA------EETQGFQRTLEAERQ------ 2351
             A +  L +    A+E   R+Q+  +++ ++L       E  Q    T E + Q      
Sbjct: 1801 LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV 1860

Query: 2352 RQLEMSA----------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR---- 2397
            RQL+  A          +A+ ++ R  E+  A     +  +  R +  + G+K       
Sbjct: 1861 RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV 1920

Query: 2398 -----------TELATQEKVTLVQTLEI-----QRQQSDHDA------------------ 2423
                        ++  QEK   V ++E+     Q  +++ DA                  
Sbjct: 1921 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1980

Query: 2424 -----ERLREAIAEL-EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
                 E ++E + +L E+ KE   K +   + L+L  E  Q  +   + +     Q+ +L
Sbjct: 1981 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2040

Query: 2475 S---------EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525
            S         E + L++R    E+  A  ++ F   + +   L   + R+QQ+ E+ER+R
Sbjct: 2041 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKR 2098

Query: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-NQRLREQLQLLEEQHR 2584
               S E + +   EAE      Q++    + ++  Q  L AE+ + R+ E +   E  + 
Sbjct: 2099 RPPSPEPSTKVSEEAE-----SQQQWDTSKGEQVSQNGLPAEQGSPRMAETVDTSEMVNG 2153

Query: 2585 AALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEP 2620
            A    +    +S + +  +    + AL   +A   P
Sbjct: 2154 ATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLP 2189



 Score =  103 bits (257), Expect = 4e-21
 Identities = 323/1633 (19%), Positives = 650/1633 (39%), Gaps = 190/1633 (11%)

Query: 1001 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1060
            +++ +  + E+ G      +   E E ++A  E    +  +R  +     +   +  LSA
Sbjct: 677  LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 734

Query: 1061 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1119
            I  ++L+  SL+ +    A+++     + LK   +      E  +T++ +KK +  AE  
Sbjct: 735  IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 793

Query: 1120 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1176
               +PT D L ++          L Q H E  DV     R R++ + ER++ V   T +R
Sbjct: 794  ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 841

Query: 1177 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1235
            ++ L+      + + E AD    W+ +  +    +Q    L D + ++ +    ++L  E
Sbjct: 842  KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 897

Query: 1236 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1295
            +     +V    + A+Q +++    E ++   + +L    S  ++  +    +  +   +
Sbjct: 898  MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 955

Query: 1296 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1346
             ++ ++ E     S    +I E  + +E  + L        A Q++    ER L  +EA 
Sbjct: 956  SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 1011

Query: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1403
            L   ++ AE   + +++   +A+ +  R+ E     EE     + ++ S+ E  +LQQ L
Sbjct: 1012 LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1068

Query: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
            R   + +      Q   A         E   +  Q E  + +    E + Q +R   E  
Sbjct: 1069 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1128

Query: 1464 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1517
               +  AQ    R R Q  D    E  +  +    L S+  A  +  R+ ++A   L  +
Sbjct: 1129 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1188

Query: 1518 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1572
            E  L   E    L  AE  +++       ++  +    A +++ R   ++     +R   
Sbjct: 1189 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1248

Query: 1573 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1620
               S+ + H    +   E   R +   + ++  ++ + EL  W          +  +EA 
Sbjct: 1249 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1307

Query: 1621 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
             L   ++ +  Q  +A+  + K+   K E E       K E +AV + +L    L K  +
Sbjct: 1308 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1363

Query: 1678 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1729
            + E T Q   QRL  A + EL     A+ ++     + Q+  ++  +         +K+Q
Sbjct: 1364 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1423

Query: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
             LE ++   + E+E L +      +E +ST E   +RL  +  +F EL E          
Sbjct: 1424 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1475

Query: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1840
              +R+  L    A+++  +  R + +++  +GE   L T  +         + +K+ +  
Sbjct: 1476 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1530

Query: 1841 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1896
             + ++  +   D+ F+R +  + + ++     I +RLA L++           L+E+T +
Sbjct: 1531 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1583

Query: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 1953
            + R++EE   A +  F+ A A     E EL  +    A+D     EQ+ +   ++ Q+  
Sbjct: 1584 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1638

Query: 1954 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2011
             A E+         +  ++L A+     +R +  + +V++L A +++    R     E  
Sbjct: 1639 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1698

Query: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2070
            R  QL +E         E+       +  Q+ +     ++   +  R      +   +  
Sbjct: 1699 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1758

Query: 2071 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127
               A+E       +AA      +          E    R Q  AA+ +L K         
Sbjct: 1759 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1814

Query: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187
                      K+      +KHKK  E+  R +  VE    TL+      +H    L  ++
Sbjct: 1815 ----------KEIFGRIQDKHKKLPEELGRDQNTVE----TLQRMHTTFEHDIQALGTQV 1860

Query: 2188 QRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEA-ENRALILRDKDNTQRFLQ 2245
            ++L+ +A  A  Q +   ++   ++ +  E L   K+ ++A E+R + L D  +  RF  
Sbjct: 1861 RQLQEDA--ARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1918

Query: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--TRL 2303
               + M  + E+  R  + AQE  + R ++  +L        + +K ++ A  ++  T +
Sbjct: 1919 MVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTTCI 1971

Query: 2304 KAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
            +    LL ++    E  +E+  +L E +++M  +  +  +  +  LE  +  +    AEA
Sbjct: 1972 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2031

Query: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQ 2417
              L       SR   ++ ++ ++  K+ E   EK   T     +  E++T ++ LE++RQ
Sbjct: 2032 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVRRQ 2090

Query: 2418 QSDHDAER---LREAIAELEREKEKLQQ--EAKLLQLKSEEMQTVQQEQLLQETQALQQS 2472
            Q + + +R     E   ++  E E  QQ   +K  Q+    +   Q    + ET      
Sbjct: 2091 QEEEERKRRPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPRMAETVD---- 2146

Query: 2473 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK----AQQLREEQQRQQQQMEQERQRLVA 2528
              SE  +    +R   +E + +     D  AK    AQ       R Q+          A
Sbjct: 2147 -TSEMVNGATEQRTSSKESSPIPSPTSDRKAKTALPAQSAATLPARTQETPS-------A 2198

Query: 2529 SMEEARRRQHEAE 2541
             ME    R+HE E
Sbjct: 2199 QMEGFLNRKHEWE 2211



 Score =  100 bits (249), Expect = 3e-20
 Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)

Query: 1144 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1203
            R G+   ++ +  ER+ +     +  L    +RQ +LEQL R  R+ R++A     WL +
Sbjct: 384  REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 440

Query: 1204 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1253
             +R   Q       D  AV    ++ +A+  +I  + E+V+     A++           
Sbjct: 441  NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 498

Query: 1254 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1311
            I A KD  ++L  Y   LE + +  ++ ++  G + + QE + +     E+    L+  Y
Sbjct: 499  ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 556

Query: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
             K +   +  + ++  L E     + ER+  V A+ +K     E +     Q  R+    
Sbjct: 557  GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 615

Query: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1429
             +   +E+ +          ++R+  EE ++L +     AE +   R+ E    S    +
Sbjct: 616  MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 668

Query: 1430 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
            +   V+RL  +  A E +  G  G  +      E+  A++      +E++R ++     R
Sbjct: 669  DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 723

Query: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547
            ++ A +E  S ++      +++      L + +  A++ +  +    ++  + V  +   
Sbjct: 724  EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 773

Query: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
                +   L  K    AE+ A    +L   H       E+A    Q+ AE+   R     
Sbjct: 774  HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 826

Query: 1608 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1661
              ER++ +  E  RLR QA  + +A  K  ++A+A +    +KE+     +   K E+  
Sbjct: 827  IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 885

Query: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1716
            V Q      E E   Q +      ++A +       +E E   QQ +L        EL  
Sbjct: 886  VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 945

Query: 1717 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
             +++A  +A + +   LE    K  +R + +V+ +++    + +   + + K       G
Sbjct: 946  RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 1000

Query: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1832
              R+L    A+L  L +EA        E    +  +  + +  +LA I +      E + 
Sbjct: 1001 MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1049

Query: 1833 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1886
             LK +EA   E  +L++   D + FQ      Q A    D+   L +  K       ++ 
Sbjct: 1050 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1109

Query: 1887 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1933
            +    E+  ++ R         Q + + + L+   +    G  EL  ++   R N     
Sbjct: 1110 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1168

Query: 1934 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 1989
               +  LR  +QAE     Q  + A  E         +  +L   E A ++++  +  + 
Sbjct: 1169 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1219

Query: 1990 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2045
               E++ A VE  RRL       S R  +       +  +  E A    ++ K+ ++LQ+
Sbjct: 1220 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1279

Query: 2046 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
             LQ  Q     + +++    + +   A       ++ +   A+     E  +++++   +
Sbjct: 1280 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1339

Query: 2102 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150
                + + +A             E L    + +A R   A +A L  +  AD +   H  
Sbjct: 1340 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1397

Query: 2151 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207
               ++  Q     ++LT++ + L++    ++Q  +  +E++ L+++A +A  Q  +  +E
Sbjct: 1398 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1455

Query: 2208 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2260
            + S R  VQ + +  L+   E ++  L  ++     R +++E     E+M    + +   
Sbjct: 1456 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1515

Query: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320
                 Q   +  Q  ++++   +   + + +     V +++ L AEA             
Sbjct: 1516 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1562

Query: 2321 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2376
             R+   D +Q+   L EET+   R L EA R +Q       AEA   +  +  MS  +A+
Sbjct: 1563 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1622

Query: 2377 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2427
             E+ A       Q   +  E+  E +H+    ++  V  +  ++  I  +QS  D  +L 
Sbjct: 1623 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1680

Query: 2428 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
              + +L  E+  KL +  +L QL  E     Q + + +++  +  L Q +  E  ++LQ 
Sbjct: 1681 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1737

Query: 2484 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2523
            ERF         I QE+        DE           +A+ +    E      ++   R
Sbjct: 1738 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1797

Query: 2524 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2580
             +++A+  E  +  H+A+E   R Q++ ++L ++  + +   E L   +      +Q L 
Sbjct: 1798 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1857

Query: 2581 EQHR 2584
             Q R
Sbjct: 1858 TQVR 1861


>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
            sapiens]
          Length = 2155

 Score =  400 bits (1028), Expect = e-110
 Identities = 536/2260 (23%), Positives = 949/2260 (41%), Gaps = 290/2260 (12%)

Query: 7    IQNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL 66
            ++     L+DER+ VQKKTFTKWVN HL +    I+DLY DLRDG  LI LLEVLSG+ L
Sbjct: 28   LEGRFKQLQDEREAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL 87

Query: 67   PRE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 125
            P+  KGRMR H L+NV  AL +L+ ++V L N+ + DI DGN +LTLGLIWTIIL FQI 
Sbjct: 88   PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQ 147

Query: 126  DIQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLI 183
            DI V  +   E  +AK+ LLLW Q    GY  +   NFT+SWRDG  FNA+IH+H+P LI
Sbjct: 148  DISVETEDNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLI 207

Query: 184  DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRV 243
            D +K+ +     NL  AF++AE+ LG+T+LLDPED+ V  PDEKSIITYV + Y    ++
Sbjct: 208  DFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYVVTYYHYFSKM 267

Query: 244  PDVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEIL 295
              +  +G R       A E +   ++Y  L   LL+W+         R+F +S   ++  
Sbjct: 268  KALAVEGKRIGKVLDNAIETEKMIEKYESLASDLLEWIEQTIIILNNRKFANSLVGVQQQ 327

Query: 296  WSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLH 352
               F  ++ +E P K  +K   + +  +++  ++A   KV     G    D+ K W +L 
Sbjct: 328  LQAFNTYRTVEKPPKFTEKGNLEVLLFTIQSKMRANNQKVYMPREGKLISDINKAWERLE 387

Query: 353  VAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKV 409
             A  ERE  LR+E  R E L+++  +   +A + E  L++   L+  D     L A    
Sbjct: 388  KAEHERELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVSQDNFGFDLPAVEAA 447

Query: 410  PQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRR---VYRLHERLVAIRTEY 466
             ++   +E D+   +  ++ +    + L+   +   +++  R   V RL E L+ +    
Sbjct: 448  TKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKRITARKDNVIRLWEYLLELLRAR 507

Query: 467  NLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDL 526
              RL+  +           LQ + +        + Y+ D   W++E +  V   ++G  L
Sbjct: 508  RQRLEMNLG----------LQKIFQE-------MLYIMD---WMDEMKVLVLSQDYGKHL 547

Query: 527  PSVEAQLGSHRGLH-------QSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQY 579
              VE  L  H  +        + +    A  ++  +D     P      RD +  ++  Y
Sbjct: 548  LGVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAHMEFCY 607

Query: 580  AKLLN---SSKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESY 636
             +L       +ARL     L  F     +E  W+ EKE+     D+    T++      +
Sbjct: 608  QELCQLAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGKDLTSVMRLLSKH 667

Query: 637  SALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHL 696
             A   E+  +    ++    G+ ++ E+H     +      ++ QW+ + QL    +  L
Sbjct: 668  RAFEDEMSGRSGHFEQAIKEGEDMIAEEHFGSEKIRERIIYIREQWANLEQLSAIRKKRL 727

Query: 697  KENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756
            +E +   QF +D  + +     + + L+   S D        + L++  +D  E++  Y+
Sbjct: 728  EEASLLHQFQADADDIDAW---MLDILKIVSSSDVGHDEYSTQSLVKKHKDVAEEIANYR 784

Query: 757  GHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQV-EVT---------------- 799
              L  L ++A A+ Q     P   +RGRL  +    YK+V E+T                
Sbjct: 785  PTLDTLHEQASALPQEHAESP--DVRGRLSGIEE-RYKEVAELTRLRKQALQDTLALYKM 841

Query: 800  VHKGDECQL------------VGPAQPSHWKVLSS--SGSEAAVPSVCFLVPPPNQEAQE 845
              + D C+L              P +    +V+       E  + +    V   NQ A++
Sbjct: 842  FSEADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQ 901

Query: 846  AV-------TRLEAQHQALVTLWHQLH--VDMK-----SLLAWQSLRRDVQLIRSWSLAT 891
             +         ++AQ   L T W Q    VD K     S L+ Q+   +    +SW    
Sbjct: 902  LMHSGHPSEKEIKAQQDKLNTRWSQFRELVDRKKDALLSALSIQNYHLECNETKSWIREK 961

Query: 892  FRTLKPEE------------------QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE 933
             + ++  +                    + L ++E       ++++      P+      
Sbjct: 962  TKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAIL 1021

Query: 934  REYGSCSHHYQQL---LQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLD 990
                  S  ++++   L++ E    E S+ Q+ + +L D +  L   +T           
Sbjct: 1022 SRLAEISDVWEEMKTTLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIA-------- 1073

Query: 991  KEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPT------LRSE 1044
               + +    + E +K   + E +   +     + +K+  + E      T      LR  
Sbjct: 1074 ---SEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQR 1130

Query: 1045 LE-LTLG--KLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP 1101
            L+ L  G  +L ++       L +       +R T+ AE  L   E  L   + +P T  
Sbjct: 1131 LQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQEYVLAHTE-MPTT-- 1187

Query: 1102 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1161
             LE  +A++KK     E    T DA  +++    E G RL     + ++  +R +E+V  
Sbjct: 1188 -LEGAEAAIKK----QEDFMTTMDANEEKINAVVETGRRLV---SDGNINSDRIQEKVDS 1239

Query: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221
            + +R +            L+   R L+ + +    L  W+ +   +    Q M   +++ 
Sbjct: 1240 IDDRHRKNRETASELLMRLKD-NRDLQKFLQDCQELSLWINE---KMLTAQDMSYDEARN 1295

Query: 1222 VREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASP--AK 1279
            +  +  + QA + E+  +           K++++ I+   +QL++ K + E V       
Sbjct: 1296 LHSKWLKHQAFMAELASN-----------KEWLDKIEKEGMQLISEKPETEAVVKEKLTG 1344

Query: 1280 KPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER 1339
              K+    ES  Q     R   +    L +Q    + + L  +E     ++ Q  +  + 
Sbjct: 1345 LHKMWEVLESTTQTKAQ-RLFDANKAELFTQSCADLDKWLHGLE-----SQIQSDDYGKD 1398

Query: 1340 LAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQ-RMQEEVVRREEAAVDAQQQKR-SIQ 1397
            L  V   L+KQ+ L       + Q E   KE+++ + Q + + +E  + D    KR ++Q
Sbjct: 1399 LTSVNILLKKQQML-------ENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQ 1451

Query: 1398 EELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV--RLQLEATERQRGGAEGELQA 1455
             +  +L +             E  + +R  +E+EI  V  R+ L AT    G     LQ 
Sbjct: 1452 TKFMELLEPLNERKHNLLASKEIHQFNR-DVEDEILWVGERMPL-ATSTDHG---HNLQT 1506

Query: 1456 LRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQA 1515
            ++   ++ +  +++ Q    R    + D  +R +    + +S     AEA R++   L+ 
Sbjct: 1507 VQLLIKKNQTLQKEIQGHQPR----IDDIFERSQNIVTDSSS---LSAEAIRQRLADLKQ 1559

Query: 1516 LEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQ 1575
            L  L +  EE E+R R+ E E  R  Q   + A+  AEA +  +     E     E   +
Sbjct: 1560 LWGLLI--EETEKRHRRLE-EAHRAQQYYFDAAE--AEAWMSEQ-----ELYMMSEEKAK 1609

Query: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1635
            +E  AV+ L++                +  E+ +E +             AE V Q    
Sbjct: 1610 DEQSAVSMLKK---------------HQILEQAVEDY-------------AETVHQLSKT 1641

Query: 1636 AQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQ---ELEKQRQLAEGTAQ----QRLA 1688
            ++A       E+ER + R+ K ++     ++LAE+   +L+++ +L +   +    ++  
Sbjct: 1642 SRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWI 1701

Query: 1689 AEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLAS 1748
            AE+E++    E  Q  +   +L+E      R+     Q+R +    LA      E++ + 
Sbjct: 1702 AEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTVNHLAD-----ELINSG 1756

Query: 1749 KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1808
             + A     +T  + K  L        EL +   ++ A + E  +    A+E   R + +
Sbjct: 1757 HSDA-----ATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQ-D 1810

Query: 1809 AERVLAEKLA----AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ 1864
              + L E+L      +    R+ T  E    + +A   ++R+L ED A    RL+   A 
Sbjct: 1811 KHKKLPEELGRDQNTVETLQRMHTTFE---HDIQALGTQVRQLQEDAA----RLQAAYAG 1863

Query: 1865 HKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELEL 1924
             KAD       ++K  +  LE  K L+ D    RR    +       F         +E 
Sbjct: 1864 DKAD------DIQKRENEVLEAWKSLL-DACESRRVRLVDTGDKFRFFSMVRDLMLWMED 1916

Query: 1925 ELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQ--KSLAAEEEAARQR 1982
             + +I   A++  R     EL     + + AE + R       ++  KSL      AR+ 
Sbjct: 1917 VIRQI--EAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSL-----LARKH 1969

Query: 1983 KAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQE 2042
             A+ E  E+L    E+ + + ++ E +    L+L  E  Q    A   A A+ + Q+   
Sbjct: 1970 YASEEIKEKLLQLTEKRKEMIDKWE-DRWEWLRLILEVHQFSRDA-SVAEAWLLGQEPYL 2027

Query: 2043 LQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAER----EAAQSRRQVEEAERLKQ- 2097
              + + Q    +++L    EA  ++A   +E     ER    E  + RRQ EE ER ++ 
Sbjct: 2028 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRP 2087

Query: 2098 -SAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136
             S E   +   +A++  +    + EQ +     AEQ + R
Sbjct: 2088 PSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQGSPR 2127



 Score =  103 bits (256), Expect = 5e-21
 Identities = 300/1528 (19%), Positives = 616/1528 (40%), Gaps = 172/1528 (11%)

Query: 1001 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSA 1060
            +++ +  + E+ G      +   E E ++A  E    +  +R  +     +   +  LSA
Sbjct: 664  LSKHRAFEDEMSGRSGHFEQAIKEGEDMIA--EEHFGSEKIRERIIYIREQWANLEQLSA 721

Query: 1061 IYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA- 1119
            I  ++L+  SL+ +    A+++     + LK   +      E  +T++ +KK +  AE  
Sbjct: 722  IRKKRLEEASLLHQFQADADDIDAWMLDILKIVSSSDVGHDEY-STQSLVKKHKDVAEEI 780

Query: 1120 --QQPTFDALRDELRGAQEVGERLQQRHGER-DVEVERWRERVAQLLERWQAVLAQTDVR 1176
               +PT D L ++          L Q H E  DV     R R++ + ER++ V   T +R
Sbjct: 781  ANYRPTLDTLHEQ-------ASALPQEHAESPDV-----RGRLSGIEERYKEVAELTRLR 828

Query: 1177 QRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP-LADSQAVREQLRQEQALLEE 1235
            ++ L+      + + E AD    W+ +  +    +Q    L D + ++ +    ++L  E
Sbjct: 829  KQALQDTLALYKMFSE-ADACELWIDEKEQWLNNMQIPEKLEDLEVIQHRF---ESLEPE 884

Query: 1236 IERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYV 1295
            +     +V    + A+Q +++    E ++   + +L    S  ++  +    +  +   +
Sbjct: 885  MNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRE--LVDRKKDALLSAL 942

Query: 1296 DLRTHYSELTTLTSQYIKFISETLRRMEEEERL--------AEQQRAEERER-LAEVEAA 1346
             ++ ++ E     S    +I E  + +E  + L        A Q++    ER L  +EA 
Sbjct: 943  SIQNYHLECNETKS----WIREKTKVIESTQDLGNDLAGVMALQRKLTGMERDLVAIEAK 998

Query: 1347 LEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQE--ELQQ-L 1403
            L   ++ AE   + +++   +A+ +  R+ E     EE     + ++ S+ E  +LQQ L
Sbjct: 999  LSDLQKEAE---KLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLGEASKLQQFL 1055

Query: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
            R   + +      Q   A         E   +  Q E  + +    E + Q +R   E  
Sbjct: 1056 RDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEEDYQKMRDMGEMV 1115

Query: 1464 EAQKRQAQEEAERLRRQVQD----ESQRKRQAEVELASRVKAEAEAAREKQRALQAL--E 1517
               +  AQ    R R Q  D    E  +  +    L S+  A  +  R+ ++A   L  +
Sbjct: 1116 TQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLRDTKQAEAFLNNQ 1175

Query: 1518 ELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLER--- 1572
            E  L   E    L  AE  +++       ++  +    A +++ R   ++     +R   
Sbjct: 1176 EYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETGRRLVSDGNINSDRIQE 1235

Query: 1573 ---SLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERW---------QLKANEAL 1620
               S+ + H    +   E   R +   + ++  ++ + EL  W          +  +EA 
Sbjct: 1236 KVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQ-ELSLWINEKMLTAQDMSYDEAR 1294

Query: 1621 RLRLQAEEVAQQKSLAQAEAEKQ---KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1677
             L   ++ +  Q  +A+  + K+   K E E       K E +AV + +L    L K  +
Sbjct: 1295 NLH--SKWLKHQAFMAELASNKEWLDKIEKEGMQLISEKPETEAVVKEKLTG--LHKMWE 1350

Query: 1678 LAEGTAQ---QRL--AAEQELIRLR-AETEQGEQ--QRQLLEEELARLQREAAAATQKRQ 1729
            + E T Q   QRL  A + EL     A+ ++     + Q+  ++  +         +K+Q
Sbjct: 1351 VLESTTQTKAQRLFDANKAELFTQSCADLDKWLHGLESQIQSDDYGKDLTSVNILLKKQQ 1410

Query: 1730 ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE 1789
             LE ++   + E+E L +      +E +ST E   +RL  +  +F EL E          
Sbjct: 1411 MLENQMEVRKKEIEELQSQAQALSQEGKSTDEVDSKRLTVQT-KFMELLEPLN------- 1462

Query: 1790 EAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAE---------IALKEKEAE 1840
              +R+  L    A+++  +  R + +++  +GE   L T  +         + +K+ +  
Sbjct: 1463 --ERKHNLL---ASKEIHQFNRDVEDEILWVGERMPLATSTDHGHNLQTVQLLIKKNQTL 1517

Query: 1841 NERLR--RLAEDEAFQRRR--LEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLR 1896
             + ++  +   D+ F+R +  + + ++     I +RLA L++           L+E+T +
Sbjct: 1518 QKEIQGHQPRIDDIFERSQNIVTDSSSLSAEAIRQRLADLKQLWGL-------LIEETEK 1570

Query: 1897 QRRQVEEEILALKASFEKAAAGKAELELELGRI-RSNAEDTLRSKEQAELEAARQRQL-- 1953
            + R++EE   A +  F+ A A     E EL  +    A+D     EQ+ +   ++ Q+  
Sbjct: 1571 RHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAKD-----EQSAVSMLKKHQILE 1625

Query: 1954 -AAEEERRRREAEERVQKSLAAEEEAARQRKAALE-EVERLKAKVEEARRLRERAEQESA 2011
             A E+         +  ++L A+     +R +  + +V++L A +++    R     E  
Sbjct: 1626 QAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKDLAEERRGKLDERH 1685

Query: 2012 RQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEE- 2070
            R  QL +E         E+       +  Q+ +     ++   +  R      +   +  
Sbjct: 1686 RLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQERFREFARDTGNIGQERVDTV 1745

Query: 2071 ---AEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR 2127
               A+E       +AA      +          E    R Q  AA+ +L K         
Sbjct: 1746 NHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDA---- 1801

Query: 2128 AQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL 2187
                      K+      +KHKK  E+  R +  VE    TL+      +H    L  ++
Sbjct: 1802 ----------KEIFGRIQDKHKKLPEELGRDQNTVE----TLQRMHTTFEHDIQALGTQV 1847

Query: 2188 QRLKAEATEAARQRSQVEEELFSVRVQMEE-LSKLKARIEA-ENRALILRDKDNTQRFLQ 2245
            ++L+ +A  A  Q +   ++   ++ +  E L   K+ ++A E+R + L D  +  RF  
Sbjct: 1848 RQLQEDA--ARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFS 1905

Query: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEA--TRL 2303
               + M  + E+  R  + AQE  + R ++  +L        + +K ++ A  ++  T +
Sbjct: 1906 MVRDLMLWM-EDVIR-QIEAQE--KPRDVSSVELLMNN---HQGIKAEIDARNDSFTTCI 1958

Query: 2304 KAEAELLQQQ---KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEA 2360
            +    LL ++    E  +E+  +L E +++M  +  +  +  +  LE  +  +    AEA
Sbjct: 1959 ELGKSLLARKHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEA 2018

Query: 2361 ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT---ELATQEKVTLVQTLEIQRQ 2417
              L       SR   ++ ++ ++  K+ E   EK   T     +  E++T ++ LE++RQ
Sbjct: 2019 WLLGQEPYLSSREIGQSVDEVEKLIKRHEAF-EKSAATWDERFSALERLTTLELLEVRRQ 2077

Query: 2418 QSDHDAER---LREAIAELEREKEKLQQ 2442
            Q + + +R     E   ++  E E  QQ
Sbjct: 2078 QEEEERKRRPPSPEPSTKVSEEAESQQQ 2105



 Score =  101 bits (251), Expect = 2e-20
 Identities = 329/1778 (18%), Positives = 687/1778 (38%), Gaps = 252/1778 (14%)

Query: 958  SRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKG 1017
            S  QR +S+  +    L A E  T     +  D     E  Q +    + + E E     
Sbjct: 426  SENQRLVSQ-DNFGFDLPAVEAATKKHEAIETDIAAYEERVQAVVAVAR-ELEAENY-HD 482

Query: 1018 VARLSAEAEKVLALPE---PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVI- 1073
            + R++A  + V+ L E       A   R E+ L L K+ Q       +++++K + L   
Sbjct: 483  IKRITARKDNVIRLWEYLLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQD 542

Query: 1074 --RGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTF-DALRDE 1130
              +   G E++L+ H   L EA  +      +    AS +K     E  +P     +RD 
Sbjct: 543  YGKHLLGVEDLLQKHT--LVEAD-IGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDR 599

Query: 1131 LRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYY 1190
            +   +   + L Q   ER   +E  R      L ++   +A+ +   RE E++       
Sbjct: 600  VAHMEFCYQELCQLAAERRARLEESRR-----LWKFFWEMAEEEGWIREKEKI------- 647

Query: 1191 RESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFA 1250
              S+D  G  L    R         L+  +A  +++       E+  + GE +   + F 
Sbjct: 648  -LSSDDYGKDLTSVMRL--------LSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG 698

Query: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310
             +    I++  + +    A LE +++  KK   ++      Q   D      ++      
Sbjct: 699  SE---KIRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADAD------DIDAWMLD 749

Query: 1311 YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1370
             +K +S +    +E    + Q   ++ + +AE  A            A A  Q   E+ +
Sbjct: 750  ILKIVSSSDVGHDE---YSTQSLVKKHKDVAEEIANYRPTLDTLHEQASALPQEHAESPD 806

Query: 1371 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1430
            ++ R+     R +E A   + +K+++Q+ L   +  SEA+        +    + ++I E
Sbjct: 807  VRGRLSGIEERYKEVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 866

Query: 1431 ---EIRVVRLQLEATERQRGGAEGELQALRARAEE-------AEAQKRQAQEEAERLRRQ 1480
               ++ V++ + E+ E +       +  +   A +       +E + +  Q++      Q
Sbjct: 867  KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 926

Query: 1481 VQDESQRKRQAEVELASRVKAEAEA------AREKQRALQALEELRLQAEEA---ERRLR 1531
             ++   RK+ A +   S      E        REK + +++ ++L          +R+L 
Sbjct: 927  FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 986

Query: 1532 QAEVERARQVQVALETAQRSAEAELQSKRASFAE----KTAQLERSLQEEHVAVAQLREE 1587
              E +    ++  L   Q+ AE +L+S+    A+    + A++   + EE     + RE 
Sbjct: 987  GMERDLVA-IEAKLSDLQKEAE-KLESEHPDQAQAILSRLAEIS-DVWEEMKTTLKNREA 1043

Query: 1588 AERRAQQQAEAERAREEAERELERWQLKA---------NEALRLRLQAEEVAQQKSLAQA 1638
            +   A +  +  R  ++ +  L R Q             EA +L  Q E +  +    + 
Sbjct: 1044 SLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKNEIDNYEE 1103

Query: 1639 EAEKQKEEAEREARRRGKAEEQAVRQR---------ELAEQELEKQRQLAEGTAQQRLAA 1689
            + +K ++  E   + +  A+   +RQR         EL +    +Q  L++  A Q+   
Sbjct: 1104 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1163

Query: 1690 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
            + +    +AE     Q+  L   E+      A AA +K+++    +     ++  ++ + 
Sbjct: 1164 DTK----QAEAFLNNQEYVLAHTEMPTTLEGAEAAIKKQEDFMTTMDANEEKINAVVETG 1219

Query: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
             R   +    S++ ++++++   R R+  E A+ L    ++ +  ++  ++         
Sbjct: 1220 RRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLWIN 1279

Query: 1810 ERVLAEKLAAIGEATRLKTE--AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKA 1867
            E++L  +  +  EA  L ++     A   + A N+      E E  Q   L  +  + +A
Sbjct: 1280 EKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ---LISEKPETEA 1336

Query: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
             ++E+L  L K            + + L    Q + + L      E      A+L+  L 
Sbjct: 1337 VVKEKLTGLHK------------MWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH 1384

Query: 1928 RIRSN--AEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA 1985
             + S   ++D  +      +   +Q+ L  + E R++E EE     L ++ +A  Q   +
Sbjct: 1385 GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEE-----LQSQAQALSQEGKS 1439

Query: 1986 LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA-------------- 2031
             +EV+  +  V+           E    L  ++E  Q     E++               
Sbjct: 1440 TDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTD 1499

Query: 2032 HAFAVQ------QKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQS 2085
            H   +Q      +K Q LQ+ +Q  Q  +D +    E ++    ++     +A R+    
Sbjct: 1500 HGHNLQTVQLLIKKNQTLQKEIQGHQPRIDDI---FERSQNIVTDSSSLSAEAIRQRLAD 1556

Query: 2086 RRQ-----VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQA 2140
             +Q     +EE E+  +  EE  +A+     AAE     +EQE    ++ +    + +Q+
Sbjct: 1557 LKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKA---KDEQS 1613

Query: 2141 ADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKN----LLDEELQRLKAEATE 2196
            A + ++KH+   EQ +   A+   +L+     L    H ++    +   ++ +L A   +
Sbjct: 1614 AVSMLKKHQ-ILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVDKLYAGLKD 1672

Query: 2197 AARQRSQVEEE---LFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQ 2253
             A +R    +E   LF +  ++++L +  A  E    +  L         LQE   + ++
Sbjct: 1673 LAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDYEHVTMLQE---RFRE 1729

Query: 2254 VAEEAARLSVAAQEAARLRQLAEE----------DLAQQRALAEKMLKEKMQAVQEATRL 2303
             A +    ++  +    +  LA+E           +A+ +    +   + ++ +   T++
Sbjct: 1730 FARDTG--NIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTRTQI 1787

Query: 2304 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLA------EETQGFQRTLEAERQ------ 2351
             A +  L +    A+E   R+Q+  +++ ++L       E  Q    T E + Q      
Sbjct: 1788 LAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALGTQV 1847

Query: 2352 RQLEMSA----------EAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHR---- 2397
            RQL+  A          +A+ ++ R  E+  A     +  +  R +  + G+K       
Sbjct: 1848 RQLQEDAARLQAAYAGDKADDIQKRENEVLEAWKSLLDACESRRVRLVDTGDKFRFFSMV 1907

Query: 2398 -----------TELATQEKVTLVQTLEI-----QRQQSDHDA------------------ 2423
                        ++  QEK   V ++E+     Q  +++ DA                  
Sbjct: 1908 RDLMLWMEDVIRQIEAQEKPRDVSSVELLMNNHQGIKAEIDARNDSFTTCIELGKSLLAR 1967

Query: 2424 -----ERLREAIAEL-EREKE---KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFL 2474
                 E ++E + +L E+ KE   K +   + L+L  E  Q  +   + +     Q+ +L
Sbjct: 1968 KHYASEEIKEKLLQLTEKRKEMIDKWEDRWEWLRLILEVHQFSRDASVAEAWLLGQEPYL 2027

Query: 2475 S---------EKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQR 2525
            S         E + L++R    E+  A  ++ F   + +   L   + R+QQ+ E+ER+R
Sbjct: 2028 SSREIGQSVDEVEKLIKRHEAFEKSAATWDERFS-ALERLTTLELLEVRRQQE-EEERKR 2085

Query: 2526 LVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEE 2563
               S E + +   EAE   +    + +Q+ Q     E+
Sbjct: 2086 RPPSPEPSTKVSEEAESQQQWDTSKGEQVSQNGLPAEQ 2123



 Score =  100 bits (249), Expect = 3e-20
 Identities = 307/1564 (19%), Positives = 623/1564 (39%), Gaps = 209/1564 (13%)

Query: 1144 RHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQD 1203
            R G+   ++ +  ER+ +     +  L    +RQ +LEQL R  R+ R++A     WL +
Sbjct: 371  REGKLISDINKAWERLEKAEHERELALRNELIRQEKLEQLAR--RFDRKAA-MRETWLSE 427

Query: 1204 ARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQY---------- 1253
             +R   Q       D  AV    ++ +A+  +I  + E+V+     A++           
Sbjct: 428  NQRLVSQDNFG--FDLPAVEAATKKHEAIETDIAAYEERVQAVVAVARELEAENYHDIKR 485

Query: 1254 INAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSEL--TTLTSQY 1311
            I A KD  ++L  Y   LE + +  ++ ++  G + + QE + +     E+    L+  Y
Sbjct: 486  ITARKDNVIRLWEY--LLELLRARRQRLEMNLGLQKIFQEMLYIMDWMDEMKVLVLSQDY 543

Query: 1312 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL 1371
             K +   +  + ++  L E     + ER+  V A+ +K     E +     Q  R+    
Sbjct: 544  GKHLL-GVEDLLQKHTLVEADIGIQAERVRGVNASAQKFATDGEGYKPCDPQVIRDRVAH 602

Query: 1372 QQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQS--SEAEIQAKARQAEAAERSRLRIE 1429
             +   +E+ +          ++R+  EE ++L +     AE +   R+ E    S    +
Sbjct: 603  MEFCYQELCQ-------LAAERRARLEESRRLWKFFWEMAEEEGWIREKEKILSSDDYGK 655

Query: 1430 EEIRVVRL--QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQR 1487
            +   V+RL  +  A E +  G  G  +      E+  A++      +E++R ++     R
Sbjct: 656  DLTSVMRLLSKHRAFEDEMSGRSGHFEQAIKEGEDMIAEEHFG---SEKIRERI--IYIR 710

Query: 1488 KRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547
            ++ A +E  S ++      +++      L + +  A++ +  +    ++  + V  +   
Sbjct: 711  EQWANLEQLSAIR------KKRLEEASLLHQFQADADDIDAWM----LDILKIVSSSDVG 760

Query: 1548 AQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAER 1607
                +   L  K    AE+ A    +L   H       E+A    Q+ AE+   R     
Sbjct: 761  HDEYSTQSLVKKHKDVAEEIANYRPTLDTLH-------EQASALPQEHAESPDVRGRLSG 813

Query: 1608 ELERWQLKANEALRLRLQA--EEVAQQKSLAQAEAEK----QKEEAEREARRRGKAEEQA 1661
              ER++ +  E  RLR QA  + +A  K  ++A+A +    +KE+     +   K E+  
Sbjct: 814  IEERYK-EVAELTRLRKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPEKLEDLE 872

Query: 1662 VRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-----EELAR 1716
            V Q      E E   Q +      ++A +       +E E   QQ +L        EL  
Sbjct: 873  VIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQFRELVD 932

Query: 1717 LQREA--AAATQKRQELEAELAK--VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
             +++A  +A + +   LE    K  +R + +V+ +++    + +   + + K       G
Sbjct: 933  RKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKL-----TG 987

Query: 1773 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEI 1832
              R+L    A+L  L +EA        E    +  +  + +  +LA I +      E + 
Sbjct: 988  MERDLVAIEAKLSDLQKEA--------EKLESEHPDQAQAILSRLAEISDVWE---EMKT 1036

Query: 1833 ALKEKEA---ENERLRRLAED-EAFQRRRLEEQAAQHKADIEERLAQLRK--ASDSELER 1886
             LK +EA   E  +L++   D + FQ      Q A    D+   L +  K       ++ 
Sbjct: 1037 TLKNREASLGEASKLQQFLRDLDDFQSWLSRTQTAIASEDMPNTLTEAEKLLTQHENIKN 1096

Query: 1887 QKGLVEDTLRQRR---------QVEEEILALKASFEKAAAGKAELELELGRIRSNA---- 1933
            +    E+  ++ R         Q + + + L+   +    G  EL  ++   R N     
Sbjct: 1097 EIDNYEEDYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELH-KMWENRQNLLSQS 1155

Query: 1934 ---EDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEV- 1989
               +  LR  +QAE     Q  + A  E         +  +L   E A ++++  +  + 
Sbjct: 1156 HAYQQFLRDTKQAEAFLNNQEYVLAHTE---------MPTTLEGAEAAIKKQEDFMTTMD 1206

Query: 1990 ---ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKE-QELQQ 2045
               E++ A VE  RRL       S R  +       +  +  E A    ++ K+ ++LQ+
Sbjct: 1207 ANEEKINAVVETGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQK 1266

Query: 2046 TLQQEQS----VLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
             LQ  Q     + +++    + +   A       ++ +   A+     E  +++++   +
Sbjct: 1267 FLQDCQELSLWINEKMLTAQDMSYDEARNLHSKWLKHQAFMAELASNKEWLDKIEKEGMQ 1326

Query: 2102 QAQARAQAQAAA-----------EKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKK 2150
                + + +A             E L    + +A R   A +A L  +  AD +   H  
Sbjct: 1327 LISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCADLDKWLH-- 1384

Query: 2151 FAEQTLRQKAQVEQELTTLRLQLEE---TDHQKNLLDEELQRLKAEATEAARQRSQVEEE 2207
               ++  Q     ++LT++ + L++    ++Q  +  +E++ L+++A +A  Q  +  +E
Sbjct: 1385 -GLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQA-QALSQEGKSTDE 1442

Query: 2208 LFSVR--VQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMK-QVAEEAAR 2260
            + S R  VQ + +  L+   E ++  L  ++     R +++E     E+M    + +   
Sbjct: 1443 VDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATSTDHGH 1502

Query: 2261 LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2320
                 Q   +  Q  ++++   +   + + +     V +++ L AEA             
Sbjct: 1503 NLQTVQLLIKKNQTLQKEIQGHQPRIDDIFERSQNIVTDSSSLSAEA------------- 1549

Query: 2321 ARRLQEDKEQMAQQLAEETQGFQRTL-EAERQRQL---EMSAEAERLKLRVAEMSRAQAR 2376
             R+   D +Q+   L EET+   R L EA R +Q       AEA   +  +  MS  +A+
Sbjct: 1550 IRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEAEAWMSEQELYMMSEEKAK 1609

Query: 2377 AEEDA-------QRFRKQAEEIGEKLHRTELATQEKV--TLVQTLEIQRQQSDHDAERLR 2427
             E+ A       Q   +  E+  E +H+    ++  V  +  ++  I  +QS  D  +L 
Sbjct: 1610 DEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALVADSHPESERISMRQSKVD--KLY 1667

Query: 2428 EAIAELEREKE-KLQQEAKLLQLKSEE---MQTVQQEQLLQETQALQQSFLSEKDSLLQR 2483
              + +L  E+  KL +  +L QL  E     Q + + +++  +  L Q +  E  ++LQ 
Sbjct: 1668 AGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAEREVVAGSHELGQDY--EHVTMLQ- 1724

Query: 2484 ERF---------IEQEKAKLEQLFQDE-----------VAKAQQLREEQQRQQQQMEQER 2523
            ERF         I QE+        DE           +A+ +    E      ++   R
Sbjct: 1725 ERFREFARDTGNIGQERVDTVNHLADELINSGHSDAATIAEWKDGLNEAWADLLELIDTR 1784

Query: 2524 QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQE---ELLAEENQRLREQLQLLE 2580
             +++A+  E  +  H+A+E   R Q++ ++L ++  + +   E L   +      +Q L 
Sbjct: 1785 TQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQNTVETLQRMHTTFEHDIQALG 1844

Query: 2581 EQHR 2584
             Q R
Sbjct: 1845 TQVR 1848



 Score =  100 bits (249), Expect = 3e-20
 Identities = 295/1531 (19%), Positives = 569/1531 (37%), Gaps = 279/1531 (18%)

Query: 355  ILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAG 414
            I ER   +R ++  LE L  I  K   EA L  +    AD +   D  +L   K+   + 
Sbjct: 702  IRERIIYIREQWANLEQLSAIRKKRLEEASLLHQFQADADDI---DAWMLDILKIVS-SS 757

Query: 415  EVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEY----NLRL 470
            +V  D     S+++   +  + + + R          +  LHE+  A+  E+    ++R 
Sbjct: 758  DVGHDEYSTQSLVKKHKDVAEEIANYRPT--------LDTLHEQASALPQEHAESPDVRG 809

Query: 471  K-AGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLA-----WVEENQHRVDGAEWGV 524
            + +G+     +VA++T     R+  L+D+   Y     A     W++E +  ++  +   
Sbjct: 810  RLSGIEERYKEVAELTRL---RKQALQDTLALYKMFSEADACELWIDEKEQWLNNMQIPE 866

Query: 525  DLPSVEAQLGSHRGLHQSIEEFRAK------IERARSDEGQLSPATRGAYRDCLGRLDLQ 578
             L  +E        L   +    ++      I R     G  S     A +D L     Q
Sbjct: 867  KLEDLEVIQHRFESLEPEMNNQASRVAVVNQIARQLMHSGHPSEKEIKAQQDKLNTRWSQ 926

Query: 579  YAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEEE-EVGFDWSDRNTNMTAKKESYS 637
            + +L++  K  L S  S+ ++     +   W+ EK +  E   D  +    + A +   +
Sbjct: 927  FRELVDRKKDALLSALSIQNYHLECNETKSWIREKTKVIESTQDLGNDLAGVMALQRKLT 986

Query: 638  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697
             + R+L   E K+ +LQ   ++L  E       + S  A +   W  M       EA L 
Sbjct: 987  GMERDLVAIEAKLSDLQKEAEKLESEHPDQAQAILSRLAEISDVWEEMKTTLKNREASLG 1046

Query: 698  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 757
            E +   QF  D+ + +  L + Q A+  +   D   T+T  E LL   ++ K +++ Y+ 
Sbjct: 1047 EASKLQQFLRDLDDFQSWLSRTQTAIASE---DMPNTLTEAEKLLTQHENIKNEIDNYEE 1103

Query: 758  HLSGLAKRAKAVVQ---------LKPRHPA--------HPM-RGRLPLLA--------VC 791
                +    + V Q         L+ R  A        H M   R  LL+        + 
Sbjct: 1104 DYQKMRDMGEMVTQGQTDAQYMFLRQRLQALDTGWNELHKMWENRQNLLSQSHAYQQFLR 1163

Query: 792  DYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSV--CFLVPPPNQEA------ 843
            D KQ E  ++   E  L     P+     +  G+EAA+            N+E       
Sbjct: 1164 DTKQAEAFLNN-QEYVLAHTEMPT-----TLEGAEAAIKKQEDFMTTMDANEEKINAVVE 1217

Query: 844  ----------------QEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSW 887
                            QE V  ++ +H+       +L + +K     Q   +D Q +  W
Sbjct: 1218 TGRRLVSDGNINSDRIQEKVDSIDDRHRKNRETASELLMRLKDNRDLQKFLQDCQELSLW 1277

Query: 888  ---SLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQ 944
                + T + +  +E R  LHS  L +QAF+ +            L + +E+        
Sbjct: 1278 INEKMLTAQDMSYDEARN-LHSKWLKHQAFMAE------------LASNKEW------LD 1318

Query: 945  QLLQSLEQGAQEESRCQRCISE-LKDIRLQLEACETRTVHRLRLPLDKEPARECAQRIAE 1003
            ++ +   Q   E+   +  + E L  +    E  E+ T  + +   D   A    Q  A+
Sbjct: 1319 KIEKEGMQLISEKPETEAVVKEKLTGLHKMWEVLESTTQTKAQRLFDANKAELFTQSCAD 1378

Query: 1004 QQK------AQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVR- 1056
              K      +Q + +  GK +  ++   +K   L            EL+     L Q   
Sbjct: 1379 LDKWLHGLESQIQSDDYGKDLTSVNILLKKQQMLENQMEVRKKEIEELQSQAQALSQEGK 1438

Query: 1057 ----------SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLP----- 1101
                      ++   ++E L+ ++        ++E+ + + +   E   V   +P     
Sbjct: 1439 STDEVDSKRLTVQTKFMELLEPLNERKHNLLASKEIHQFNRDVEDEILWVGERMPLATST 1498

Query: 1102 ----ELEATKASLKK---LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD-VEVE 1153
                 L+  +  +KK   L+ + +  QP  D          ++ ER Q    +   +  E
Sbjct: 1499 DHGHNLQTVQLLIKKNQTLQKEIQGHQPRID----------DIFERSQNIVTDSSSLSAE 1548

Query: 1154 RWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQA 1213
              R+R+A L + W  ++ +T+ R R LE+  R  +YY ++A+   AW+ +  +    +  
Sbjct: 1549 AIRQRLADLKQLWGLLIEETEKRHRRLEEAHRAQQYYFDAAEA-EAWMSE--QELYMMSE 1605

Query: 1214 MPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEP 1273
                D Q+    L++ Q L + +E + E V +  + ++  + A    E + ++ +     
Sbjct: 1606 EKAKDEQSAVSMLKKHQILEQAVEDYAETVHQLSKTSRALV-ADSHPESERISMRQ---- 1660

Query: 1274 VASPAKKPKVQSGSESVIQEY---VDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330
                +K  K+ +G + + +E    +D R    +L        ++I+E       E     
Sbjct: 1661 ----SKVDKLYAGLKDLAEERRGKLDERHRLFQLNREVDDLEQWIAE------REVVAGS 1710

Query: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEA-AVDA 1389
             +  ++ E +  ++   E+ R+ A    +      +E  +    + +E++    + A   
Sbjct: 1711 HELGQDYEHVTMLQ---ERFREFA----RDTGNIGQERVDTVNHLADELINSGHSDAATI 1763

Query: 1390 QQQKRSIQEELQQLRQSSEAEIQAKARQAEA-------------AERSRLRIEEEIRVVR 1436
             + K  + E    L +  +   Q  A   E               +    ++ EE+   +
Sbjct: 1764 AEWKDGLNEAWADLLELIDTRTQILAASYELHKFYHDAKEIFGRIQDKHKKLPEELGRDQ 1823

Query: 1437 LQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQ---RKRQAEV 1493
              +E  +R     E ++QAL         Q RQ QE+A RL+     +     +KR+ EV
Sbjct: 1824 NTVETLQRMHTTFEHDIQALGT-------QVRQLQEDAARLQAAYAGDKADDIQKRENEV 1876

Query: 1494 ELASRVKAEAEAAR--------EKQRALQALEELRLQAEEAERRLRQAEVERARQVQVAL 1545
              A +   +A  +R        +K R    + +L L  E+  R++   E  R       L
Sbjct: 1877 LEAWKSLLDACESRRVRLVDTGDKFRFFSMVRDLMLWMEDVIRQIEAQEKPRDVSSVELL 1936

Query: 1546 ETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEA 1605
                +  +AE+ ++  SF       +  L  +H A  +++E+  +        E+ +E  
Sbjct: 1937 MNNHQGIKAEIDARNDSFTTCIELGKSLLARKHYASEEIKEKLLQLT------EKRKEMI 1990

Query: 1606 ERELERWQLKANEALRLRLQAEEVAQQKSLAQA-------------------EAEK---- 1642
            ++  +RW     E LRL L+  + ++  S+A+A                   E EK    
Sbjct: 1991 DKWEDRW-----EWLRLILEVHQFSRDASVAEAWLLGQEPYLSSREIGQSVDEVEKLIKR 2045

Query: 1643 -----------------------------QKEEAEREARRRGKAEEQAVRQRELAEQELE 1673
                                         ++++ E E +RR  + E + +  E AE + +
Sbjct: 2046 HEAFEKSAATWDERFSALERLTTLELLEVRRQQEEEERKRRPPSPEPSTKVSEEAESQQQ 2105

Query: 1674 KQRQLAEGTAQQRLAAEQELIRL--RAETEQ 1702
                  E  +Q  L AEQ   R+  R++T Q
Sbjct: 2106 WDTSKGEQVSQNGLPAEQGSPRVSYRSQTYQ 2136


>gi|67782321 spectrin beta isoform a [Homo sapiens]
          Length = 2328

 Score =  377 bits (969), Expect = e-103
 Identities = 529/2203 (24%), Positives = 907/2203 (41%), Gaps = 277/2203 (12%)

Query: 8    QNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP 67
            ++ I +L DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP
Sbjct: 42   RSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLP 101

Query: 68   RE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 126
            +  KG+MR H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI D
Sbjct: 102  KPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQD 161

Query: 127  IQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184
            I V  Q   E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID
Sbjct: 162  IVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLID 221

Query: 185  MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244
             +K+       NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++ 
Sbjct: 222  FDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMK 281

Query: 245  DVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 296
             +  +G R       A E +   ++Y  L   LL W+         R+F +S   ++   
Sbjct: 282  VLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQL 341

Query: 297  SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHV 353
              F  ++ +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  
Sbjct: 342  QAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEE 401

Query: 354  AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVP 410
            A   RE  LR+E  R E L+++  +   +A + E  L++   L+  D     L A     
Sbjct: 402  AEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAK 461

Query: 411  QRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 469
            ++   +E D    +  +R L +  Q L K+  H Q             + +  R +  LR
Sbjct: 462  KKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILR 508

Query: 470  LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDL 526
            L            Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L
Sbjct: 509  L--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHL 560

Query: 527  PSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYA 580
              VE  L  H+ +   I     K++       +  EG+   P      +D +  L+  + 
Sbjct: 561  LEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFE 620

Query: 581  KLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 637
            +L N +   KA+L   + L  F     +   W+ EKE+     D+    T++   +  + 
Sbjct: 621  ELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHK 680

Query: 638  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697
            A   EL   +  ++++      ++       P +E+    +  QW  +  L    + +L+
Sbjct: 681  AFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQ 740

Query: 698  ENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756
            +   +FQF  D  + +  LQ     L       D  AT      L +  +D  E+L E +
Sbjct: 741  DAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESR 796

Query: 757  GHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHK 802
            G +  L ++A+   +     P   H ++    L    +A  D +Q        +     +
Sbjct: 797  GVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGE 856

Query: 803  GDECQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCF 834
             D C+L +G  +                             K L +   G   A  S+  
Sbjct: 857  TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE 916

Query: 835  LVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW------- 874
               P ++E ++    L  + QA  TL              H   VD +    W       
Sbjct: 917  SGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKV 976

Query: 875  ----QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 930
                + L RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE + 
Sbjct: 977  VESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK- 1029

Query: 931  MAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVH 983
                + G    H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V 
Sbjct: 1030 ---EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVA 1085

Query: 984  RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1043
               +P   E   E  Q + +    + E++G      R+    EKV+   +  P    L  
Sbjct: 1086 SEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQ 1141

Query: 1044 ELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1097
             LE        LG++ + RS +   L +        +  + AE +L   E  L   +   
Sbjct: 1142 RLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPD 1198

Query: 1098 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157
            +    LEA +A ++K     E    + +  RD++    + G +L     E ++  ++ +E
Sbjct: 1199 S----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKE 1247

Query: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAM 1214
            +V  + +R +    + + + +E   L R   +L+ + ++   L  W+ D     + +   
Sbjct: 1248 KVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS-- 1301

Query: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL--- 1271
               +++ +  +  + QA + E+  H   +E      KQ ++  K     LV+ K +    
Sbjct: 1302 -YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHR 1359

Query: 1272 ---EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1328
               E  A+  +K +  S + S     + L+TH        +++I  + + LR  +  + L
Sbjct: 1360 LWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDL 1411

Query: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRRE 1383
                R   + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R 
Sbjct: 1412 TSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRR 1470

Query: 1384 EAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
            +  +++ + K  I  +L        ++L  +  A+     +  +   +    ++ EI   
Sbjct: 1471 KKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH 1530

Query: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
              ++E    QRG  +  ++A     ++ E +    Q   +RLR       QR R A    
Sbjct: 1531 TPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587

Query: 1496 ASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETA 1548
               + A EAEA   +Q      +E+    E A    +R LRQ  A  +  R ++     A
Sbjct: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647

Query: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1608
            Q      L S      E+  +L+  + + +  +  + EE +R+ +      + + E + +
Sbjct: 1648 Q-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-D 1701

Query: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668
            LE+W            + E VA    + Q   +       R+  R    E  A+ Q  + 
Sbjct: 1702 LEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVD 1748

Query: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
                  +R +  G ++    AE        +    E    LLE    R+Q  AA+    R
Sbjct: 1749 NVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHR 1801

Query: 1729 Q--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
                      L  E  +   E   L AS A +     +  E+    L  +  +F+++A  
Sbjct: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861

Query: 1781 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1840
                 A  E+A+  +   +E +A  +A  +       A  G  T+L   A     +K   
Sbjct: 1862 LQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRF 1908

Query: 1841 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVED 1893
                R L        R++E Q         E L +  +  ++E+E R K       L E 
Sbjct: 1909 FSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGES 1968

Query: 1894 TLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---AR 1949
             L+++ Q  EEI   L+    +      + E    R+R   E    S++ +  EA   A+
Sbjct: 1969 LLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQ 2028

Query: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERA 2006
            +  LA+ +     ++ E++ K   A E++     +R AALE+   L+ K    R++ ER 
Sbjct: 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERP 2085

Query: 2007 EQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQ 2049
             +E+  Q +  + A +  +         +  ++E    Q LQQ
Sbjct: 2086 AEETGPQEEEGETAGEAPVSHHAATERTSPGEEEGTWPQNLQQ 2128



 Score =  101 bits (251), Expect = 2e-20
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 1129 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1188
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641

Query: 1189 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1240
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700

Query: 1241 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1298
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756

Query: 1299 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1358
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806

Query: 1359 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860

Query: 1417 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1476
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920

Query: 1477 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1527
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980

Query: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038

Query: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096

Query: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1702
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156

Query: 1703 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1758
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215

Query: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268

Query: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319

Query: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369

Query: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 1996
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421

Query: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463

Query: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506

Query: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558

Query: 2177 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2226
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615

Query: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2282
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675

Query: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2323
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734

Query: 2324 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2377
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794

Query: 2378 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2415
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851

Query: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2466
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902

Query: 2467 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959

Query: 2527 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016

Query: 2584 RAALAHS 2590
             A++A +
Sbjct: 2017 DASVAEA 2023



 Score = 78.2 bits (191), Expect = 2e-13
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1308
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382

Query: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1368
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438

Query: 1369 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1417
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498

Query: 1418 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1473
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557

Query: 1474 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1513
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615

Query: 1514 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1556
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675

Query: 1557 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1598
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735

Query: 1599 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791

Query: 1650 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851

Query: 1695 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911

Query: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966

Query: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1867
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009

Query: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061

Query: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108

Query: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2035
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165

Query: 2036 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2086
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225

Query: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277

Query: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2206
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331

Query: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2266
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390

Query: 2267 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2320
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448

Query: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2378
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507

Query: 2379 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2424
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567

Query: 2425 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2479
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625

Query: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677

Query: 2540 AEEGVRRKQEELQQLEQQRRQQEEL 2564
              E  +RK E +  L Q +R+ ++L
Sbjct: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329

Query: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1766
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387

Query: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444

Query: 1827 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1881
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504

Query: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1933
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563

Query: 1934 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 1990
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623

Query: 1991 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2044
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683

Query: 2045 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740

Query: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2160
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798

Query: 2161 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2211
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857

Query: 2212 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914

Query: 2269 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974

Query: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032

Query: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2438
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091

Query: 2439 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2492
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151

Query: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2548
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211

Query: 2549 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2594
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 1978
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460

Query: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2034
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512

Query: 2035 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572

Query: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2144
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632

Query: 2145 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2186
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692

Query: 2187 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747

Query: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794

Query: 2303 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852

Query: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907

Query: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2471
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967

Query: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026

Query: 2532 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2589
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079

Query: 2590 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2649
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126

Query: 2650 LAQGHTTVDEL 2660
            + QG T  + L
Sbjct: 1127 VIQGQTDPEYL 1137



 Score = 74.3 bits (181), Expect = 3e-12
 Identities = 302/1499 (20%), Positives = 557/1499 (37%), Gaps = 179/1499 (11%)

Query: 1010 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1069
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742

Query: 1070 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1129
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793

Query: 1130 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1189
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853

Query: 1190 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1249
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884

Query: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1306
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941

Query: 1307 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000

Query: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1408
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056

Query: 1409 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1456
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116

Query: 1457 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1511
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176

Query: 1512 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1564
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236

Query: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1621
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294

Query: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349

Query: 1682 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1737
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409

Query: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1792
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469

Query: 1793 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1845
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529

Query: 1846 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586

Query: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642

Query: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2023
               R Q  L+A      Q      +V++  A +++    R+R  +      QL +E    
Sbjct: 1643 LASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL 1702

Query: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-EAARRAAEEAEEARVQAER-- 2080
                 EK     +     E+ Q       + D+ R  A E      E  +      ER  
Sbjct: 1703 EQWISEK----ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLI 1758

Query: 2081 -----EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQA 2133
                 EAA      +    +     E    R Q  AA+  L +      E       +  
Sbjct: 1759 DAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHR 1818

Query: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193
             L +    DA        AE   R     E+EL  L +Q+++       L       KAE
Sbjct: 1819 ELPEDVGLDAST------AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAE 1872

Query: 2194 ATE----------------AARQRSQVEE-----ELFSV-RVQMEELSKLKARIEAENRA 2231
            A +                 A +R+Q+ +       FS+ R  +  +  +  +IE + R 
Sbjct: 1873 AIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERP 1932

Query: 2232 LILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEK 2288
              +   +   ++ Q   AE   +    +A L +      R  Q +EE  +  QQ     K
Sbjct: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRK 1992

Query: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
             + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +          ++ ++ 
Sbjct: 1993 EMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKR 2050

Query: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2407
                +   ++ AER     A + +      ++ Q   + AEE G +    E A +  V+
Sbjct: 2051 HEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVS 2105


>gi|67782319 spectrin beta isoform b [Homo sapiens]
          Length = 2137

 Score =  376 bits (966), Expect = e-103
 Identities = 532/2209 (24%), Positives = 910/2209 (41%), Gaps = 280/2209 (12%)

Query: 8    QNEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP 67
            ++ I +L DER+ VQKKTFTKWVN HL +    I+DLY+DLRDG  LI LLEVLSG+ LP
Sbjct: 42   RSRIKALADEREVVQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEMLP 101

Query: 68   RE-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 126
            +  KG+MR H L+NV  AL +L+ ++V L N+ + DI DGN +L LGLIWTIIL FQI D
Sbjct: 102  KPTKGKMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQD 161

Query: 127  IQVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLID 184
            I V  Q   E  +AK+ LLLW Q    GY  +   NFTSSW+DG  FNA+IH+H+P LID
Sbjct: 162  IVVQTQEGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLID 221

Query: 185  MNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVP 244
             +K+       NL+ AF+VAER LG+  LLDPEDV    PDEKSIITYV + Y    ++ 
Sbjct: 222  FDKLKDSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAFYHYFSKMK 281

Query: 245  DVQ-DGVR-------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILW 296
             +  +G R       A E +   ++Y  L   LL W+         R+F +S   ++   
Sbjct: 282  VLAVEGKRVGKVIDHAIETEKMIEKYSGLASDLLTWIEQTITVLNSRKFANSLTGVQQQL 341

Query: 297  SQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV---PPGYHPLDVEKEWGKLHV 353
              F  ++ +E P K  +K   + +  +++  ++A   KV     G    D+ + W  L  
Sbjct: 342  QAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGKLVSDINRAWESLEE 401

Query: 354  AILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVP 410
            A   RE  LR+E  R E L+++  +   +A + E  L++   L+  D     L A     
Sbjct: 402  AEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAAK 461

Query: 411  QRAGEVERDLDKADSMIRLLFNDVQTL-KDGRHPQGEQMYRRVYRLHERLVAIRTEYNLR 469
            ++   +E D    +  +R L +  Q L K+  H Q             + +  R +  LR
Sbjct: 462  KKHEAIETDTAAYEERVRALEDLAQELEKENYHDQ-------------KRITARKDNILR 508

Query: 470  LKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLL---AWVEENQHRVDGAEWGVDL 526
            L            Q  LQS ++R E   +  +  QD+L    W++E +  +  AE+G  L
Sbjct: 509  L--------WSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHL 560

Query: 527  PSVEAQLGSHRGLHQSIEEFRAKIE-----RARSDEGQ-LSPATRGAYRDCLGRLDLQYA 580
              VE  L  H+ +   I     K++       +  EG+   P      +D +  L+  + 
Sbjct: 561  LEVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFE 620

Query: 581  KLLNSS---KARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYS 637
            +L N +   KA+L   + L  F     +   W+ EKE+     D+    T++   +  + 
Sbjct: 621  ELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHK 680

Query: 638  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697
            A   EL   +  ++++      ++       P +E+    +  QW  +  L    + +L+
Sbjct: 681  AFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKNLQ 740

Query: 698  ENAAYFQFFSDVREAEGQLQKLQEALR-RKYSCDRSATVTRLEDLLQDAQDEKEQLNEYK 756
            +   +FQF  D  + +  LQ     L       D  AT      L +  +D  E+L E +
Sbjct: 741  DAENFFQFQGDADDLKAWLQDAHRLLSGEDVGQDEGAT----RALGKKHKDFLEELEESR 796

Query: 757  GHLSGLAKRAKAVVQLKPRHP--AHPMRGRLPL----LAVCDYKQ--------VEVTVHK 802
            G +  L ++A+   +     P   H ++    L    +A  D +Q        +     +
Sbjct: 797  GVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTVFGE 856

Query: 803  GDECQL-VGPAQ-------------------------PSHWKVLSS--SGSEAAVPSVCF 834
             D C+L +G  +                             K L +   G   A  S+  
Sbjct: 857  TDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVE 916

Query: 835  LVPPPNQEAQEAVTRLEAQHQALVTL-------------WHQLHVDMKSLLAW------- 874
               P ++E ++    L  + QA  TL              H   VD +    W       
Sbjct: 917  SGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKV 976

Query: 875  ----QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRL 930
                + L RD+  I    +A  R L   E+  A  +++    A  R+SQ      PE + 
Sbjct: 977  VESTKDLGRDLAGI----IAIQRKLSGLERDVA--AIQARVDALERESQQLMDSHPEQK- 1029

Query: 931  MAEREYGSCSHHYQQLLQSLEQGAQ-------EESRCQRCISELKDIRLQLEACETRTVH 983
                + G    H ++L Q L+Q  Q       E S+ Q  + +L D +  L   + + V 
Sbjct: 1030 ---EDIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQ-KAVA 1085

Query: 984  RLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRS 1043
               +P   E   E  Q + +    + E++G      R+    EKV+   +  P    L  
Sbjct: 1086 SEDMP---ESLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQ-GQTDPEYLLLGQ 1141

Query: 1044 ELE------LTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVP 1097
             LE        LG++ + RS +   L +        +  + AE +L   E  L   +   
Sbjct: 1142 RLEGLDTGWNALGRMWESRSHT---LAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPD 1198

Query: 1098 ATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRE 1157
            +    LEA +A ++K     E    + +  RD++    + G +L     E ++  ++ +E
Sbjct: 1199 S----LEAAEAGIRKF----EDFLGSMENNRDKVLSPVDSGNKLV---AEGNLYSDKIKE 1247

Query: 1158 RVAQLLERWQAVLAQTDVRQRELEQLGR---QLRYYRESADPLGAWLQDARRRQEQIQAM 1214
            +V  + +R +    + + + +E   L R   +L+ + ++   L  W+ D     + +   
Sbjct: 1248 KVQLIEDRHR----KNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKLLTSQDVS-- 1301

Query: 1215 PLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQL--- 1271
               +++ +  +  + QA + E+  H   +E      KQ ++  K     LV+ K +    
Sbjct: 1302 -YDEARNLHNKWLKHQAFVAELASHEGWLENIDAEGKQLMDE-KPQFTALVSQKLEALHR 1359

Query: 1272 ---EPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERL 1328
               E  A+  +K +  S + S     + L+TH        +++I  + + LR  +  + L
Sbjct: 1360 LWDELQATTKEKTQHLSAARS---SDLRLQTHAD-----LNKWISAMEDQLRSDDPGKDL 1411

Query: 1329 AEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK---ELQQRMQE--EVVRRE 1383
                R   + +  E +  + K+ +L E  AQ  +  E        +++R  +  E + R 
Sbjct: 1412 TSVNRMLAKLKRVEDQVNVRKE-ELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGRR 1470

Query: 1384 EAAVDAQQQKRSIQEEL--------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
            +  +++ + K  I  +L        ++L  +  A+     +  +   +    ++ EI   
Sbjct: 1471 KKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILGH 1530

Query: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
              ++E    QRG  +  ++A     ++ E +    Q   +RLR       QR R A    
Sbjct: 1531 TPRVEDV-LQRG--QQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQRLRDANEAQ 1587

Query: 1496 ASRVKA-EAEAAREKQRALQALEELRLQAEEA----ERRLRQ--AEVERARQVQVALETA 1548
               + A EAEA   +Q      +E+    E A    +R LRQ  A  +  R ++     A
Sbjct: 1588 QYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKRHLRQQRAVEDYGRNIKQLASRA 1647

Query: 1549 QRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERE 1608
            Q      L S      E+  +L+  + + +  +  + EE +R+ +      + + E + +
Sbjct: 1648 Q-----GLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETD-D 1701

Query: 1609 LERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELA 1668
            LE+W            + E VA    + Q   +       R+  R    E  A+ Q  + 
Sbjct: 1702 LEQW----------ISEKELVASSPEMGQ---DFDHVTLLRDKFRDFARETGAIGQERVD 1748

Query: 1669 EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKR 1728
                  +R +  G ++    AE        +    E    LLE    R+Q  AA+    R
Sbjct: 1749 NVNAFIERLIDAGHSEAATIAEW-------KDGLNEMWADLLELIDTRMQLLAASYDLHR 1801

Query: 1729 Q--------ELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1780
                      L  E  +   E   L AS A +     +  E+    L  +  +F+++A  
Sbjct: 1802 YFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHLLGVQVQQFQDVATR 1861

Query: 1781 AARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAE 1840
                 A  E+A+  +   +E +A  +A  +       A  G  T+L   A     +K   
Sbjct: 1862 LQTAYA-GEKAEAIQNKEQEVSAAWQALLD-------ACAGRRTQLVDTA-----DKFRF 1908

Query: 1841 NERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELE-RQKG------LVED 1893
                R L        R++E Q         E L +  +  ++E+E R K       L E 
Sbjct: 1909 FSMARDLLSWMESIIRQIETQERPRDVSSVELLMKYHQGINAEIETRSKNFSACLELGES 1968

Query: 1894 TLRQRRQVEEEIL-ALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA---AR 1949
             L+++ Q  EEI   L+    +      + E    R+R   E    S++ +  EA   A+
Sbjct: 1969 LLQRQHQASEEIREKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSRDASVAEAWLIAQ 2028

Query: 1950 QRQLAAEEERRRREAEERVQKSLAAEEEAA---RQRKAALEEVERLKAKVEEARRLRERA 2006
            +  LA+ +     ++ E++ K   A E++     +R AALE+   L+ K    R++ ER 
Sbjct: 2029 EPYLASGDFGHTVDSVEKLIKRHEAFEKSTASWAERFAALEKPTTLELK---ERQIAERP 2085

Query: 2007 EQESARQL---QLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
             +E+  Q    + A EA      A E+    ++  +     ++LQ E S
Sbjct: 2086 AEETGPQEEEGETAGEAPVSHHAATERTSPVSLWSRLSSSWESLQPEPS 2134



 Score =  101 bits (251), Expect = 2e-20
 Identities = 315/1567 (20%), Positives = 607/1567 (38%), Gaps = 230/1567 (14%)

Query: 1129 DELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLR 1188
            D+++       +  +  G +  + +  ++R++ L + ++ +      R+ +LEQ  R  +
Sbjct: 582  DKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQLEQSKRLWK 641

Query: 1189 YYRESADPLGAWLQDARRRQEQIQAMPLADS--------QAVREQLRQEQALLEEIERHG 1240
            ++ E  D   +W+++  +    +       S        +A  ++LR   A LE+I +  
Sbjct: 642  FFWEM-DEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAHLEQIFQEA 700

Query: 1241 EKVEECQRFAKQYINA-IKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQ-EYVDLR 1298
              +   ++F    I A IK+   Q      QL+ +A+  KK    + +    Q +  DL+
Sbjct: 701  HGMVARKQFGHPQIEARIKEVSAQW----DQLKDLAAFCKKNLQDAENFFQFQGDADDLK 756

Query: 1299 THYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHA 1358
                +   L S       E + + E   R   ++  +  E L E    +E   Q     A
Sbjct: 757  AWLQDAHRLLS------GEDVGQDEGATRALGKKHKDFLEELEESRGVMEHLEQ----QA 806

Query: 1359 QAKAQAEREAKELQQRMQ--EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKAR 1416
            Q   +  R++ ++  R+Q   E+ ++  A  D +QQ+  +QE L       E +    A 
Sbjct: 807  QGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQR--LQEALDLYTVFGETD----AC 860

Query: 1417 QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1476
            +    E+ +   E E+      LE  + +    + E++ L  + +          E    
Sbjct: 861  ELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSLVESGHP 920

Query: 1477 LRRQV---QDESQRKRQAEVELASRVKAEAEAAREKQRALQALEEL------RLQAEEAE 1527
              R+V   QD    + QA   L S  +   ++A          EE       + +  E+ 
Sbjct: 921  RSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVEST 980

Query: 1528 RRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREE 1587
            + L + ++     +Q  L   +R   A +Q++  +   ++ QL  S  E+   + Q ++ 
Sbjct: 981  KDLGR-DLAGIIAIQRKLSGLERDVAA-IQARVDALERESQQLMDSHPEQKEDIGQRQKH 1038

Query: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEA 1647
             E   Q   ++ + +E+   E+   QL+A        QA     QK++A  +  +   EA
Sbjct: 1039 LEELWQGLQQSLQGQEDLLGEVS--QLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEA 1096

Query: 1648 EREARRRGKAEEQAVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRL----RAETEQ 1702
            E+  ++    +++    ++  ++  E   ++ +G T  + L   Q L  L     A    
Sbjct: 1097 EQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRM 1156

Query: 1703 GEQQRQLLEEELA--RLQREAAAATQKRQELEAELAKVRAEMEVLLASKA--RAEEESRS 1758
             E +   L + L     Q++A  A       E  LA +    + L A++A  R  E+   
Sbjct: 1157 WESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPP-DSLEAAEAGIRKFEDFLG 1215

Query: 1759 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA 1818
            + E ++ ++ +      +L  E       +++ K + QL E+   +   +A+    E   
Sbjct: 1216 SMENNRDKVLSPVDSGNKLVAEG---NLYSDKIKEKVQLIEDRHRKNNEKAQ----EASV 1268

Query: 1819 AIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRK 1878
             + +   L+   +   +     N++L    +    + R L  +  +H+A +         
Sbjct: 1269 LLRDNLELQNFLQNCQELTLWINDKLLTSQDVSYDEARNLHNKWLKHQAFV--------- 1319

Query: 1879 ASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLR 1938
               +EL   +G +E+   + +Q+ +E    K  F    + K E    L R+    + T +
Sbjct: 1320 ---AELASHEGWLENIDAEGKQLMDE----KPQFTALVSQKLEA---LHRLWDELQATTK 1369

Query: 1939 SKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAA--LEEVERLKAKV 1996
             K Q  L AAR   L       R +    + K ++A E+  R       L  V R+ AK+
Sbjct: 1370 EKTQ-HLSAARSSDL-------RLQTHADLNKWISAMEDQLRSDDPGKDLTSVNRMLAKL 1421

Query: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ 2056
            +         +Q + R+ +L +  AQ     EE   A             L  E+  LD 
Sbjct: 1422 KRVE------DQVNVRKEELGELFAQVPSMGEEGGDA------------DLSIEKRFLDL 1463

Query: 2057 LRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKL 2116
            L  E    R+   E+  A++Q  R+       VEE   L QSA+                
Sbjct: 1464 L--EPLGRRKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADY--------------- 1506

Query: 2117 RKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET 2176
                        Q  Q  +++ Q    E+  H    E  L++  Q+ +        LEE 
Sbjct: 1507 --------GTNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEER 1558

Query: 2177 --------DHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--E 2226
                    D  +      LQRL+ +A EA  Q+  ++ +     +  +EL  +   I  +
Sbjct: 1559 LGHLQSSWDRLREAAAGRLQRLR-DANEA--QQYYLDADEAEAWIGEQELYVISDEIPKD 1615

Query: 2227 AENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAA----QEAARLRQLAEEDLAQQ 2282
             E   ++L+     QR +++    +KQ+A  A  L  A     ++  RL+   ++  A  
Sbjct: 1616 EEGAIVMLKRHLRQQRAVEDYGRNIKQLASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGL 1675

Query: 2283 RALAEKMLKEKMQAVQEATRLKAEAELLQQ---QKELA----------------QEQARR 2323
            + +AE+  K K++ +    +LK E + L+Q   +KEL                 +++ R 
Sbjct: 1676 KDVAEER-KRKLENMYHLFQLKRETDDLEQWISEKELVASSPEMGQDFDHVTLLRDKFRD 1734

Query: 2324 LQEDKEQMAQQLAEETQGF-QRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARA 2377
               +   + Q+  +    F +R ++A       ++   + L    A++     +R Q  A
Sbjct: 1735 FARETGAIGQERVDNVNAFIERLIDAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLA 1794

Query: 2378 EE-DAQRF---------------RKQAEEIG------EKLHRTELATQEKVTLVQTLEIQ 2415
               D  R+               R+  E++G      E  HR   A + ++ L   L +Q
Sbjct: 1795 ASYDLHRYFYTGAEILGLIDEKHRELPEDVGLDASTAESFHRVHTAFERELHL---LGVQ 1851

Query: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL---------LQET 2466
             QQ    A RL+ A A          ++A+ +Q K +E+    Q  L         L +T
Sbjct: 1852 VQQFQDVATRLQTAYAG---------EKAEAIQNKEQEVSAAWQALLDACAGRRTQLVDT 1902

Query: 2467 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRL 2526
                + F   +D L   E  I Q +    Q    +V+  + L +  Q    ++E   +  
Sbjct: 1903 ADKFRFFSMARDLLSWMESIIRQIET---QERPRDVSSVELLMKYHQGINAEIETRSKNF 1959

Query: 2527 VASMEEAR---RRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQH 2583
             A +E      +RQH+A E +R   E+LQQ+  +R++  E      +RLR  L++ +   
Sbjct: 1960 SACLELGESLLQRQHQASEEIR---EKLQQVMSRRKEMNEKWEARWERLRMLLEVCQFSR 2016

Query: 2584 RAALAHS 2590
             A++A +
Sbjct: 2017 DASVAEA 2023



 Score = 78.2 bits (191), Expect = 2e-13
 Identities = 290/1465 (19%), Positives = 560/1465 (38%), Gaps = 239/1465 (16%)

Query: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQS-GSESVIQEYVDLRTHYSELTTLT 1308
            ++++ N++   + QL  +        +  K PK Q  G+  V+   +  R   +     T
Sbjct: 327  SRKFANSLTGVQQQLQAFSTY----RTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYT 382

Query: 1309 SQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREA 1368
                K +S+  R  E  E    ++    R  L   E    K  QLA    +  A  E   
Sbjct: 383  PHDGKLVSDINRAWESLEEAEYRRELALRNELIRQE----KLEQLARRFDRKAAMRETWL 438

Query: 1369 KELQQRMQEEVVRREEAAVDAQQQKRSIQE-----------ELQQLRQSSEAEIQAKARQ 1417
             E Q+ + ++    + AAV+A ++K    E            L+ L Q  E E     ++
Sbjct: 439  SENQRLVAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKR 498

Query: 1418 AEAAERSRLR----IEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE 1473
              A + + LR    ++E ++  R +LE T   +   +  L ++    +E +A    A+  
Sbjct: 499  ITARKDNILRLWSYLQELLQSRRQRLETTLALQKLFQDMLHSI-DWMDEIKAHLLSAEFG 557

Query: 1474 AERLRRQVQDESQRKRQAEVELA---SRVKA-----------------EAEAAREKQRAL 1513
               L  +V+D  Q+ +  E ++A    +VKA                 + +  +++   L
Sbjct: 558  KHLL--EVEDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHL 615

Query: 1514 -QALEELRLQAEEAERRLRQAE---------------VERARQVQVALETAQ-RSAEAEL 1556
             Q  EEL   A   + +L Q++               ++   Q+  +L+  +  ++   L
Sbjct: 616  EQCFEELSNMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLIL 675

Query: 1557 QSKRASFAEK----TAQLERSLQEEHVAVAQLR---EEAERRAQQ-----------QAEA 1598
            Q K  +F ++     A LE+  QE H  VA+ +    + E R ++            A  
Sbjct: 676  QRKHKAFEDELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFC 735

Query: 1599 ERAREEAER---------ELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAER 1649
            ++  ++AE          +L+ W     +A RL L  E+V Q +   +A  +K K+  E 
Sbjct: 736  KKNLQDAENFFQFQGDADDLKAW---LQDAHRL-LSGEDVGQDEGATRALGKKHKDFLEE 791

Query: 1650 EARRRG---KAEEQA------------VRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
                RG     E+QA            V  R  A +EL +Q        QQRL    +L 
Sbjct: 792  LEESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLY 851

Query: 1695 RLRAETE-----QGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
             +  ET+      GE+++ L E E+     +      +   L+ E+  +  +++ +  + 
Sbjct: 852  TVFGETDACELWMGEKEKWLAEMEMPDTLEDLEVVQHRFDILDQEMKTLMTQIDGVNLAA 911

Query: 1750 ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEA 1809
                E     S + KQ  +    R++      +  R   + A R      +       E 
Sbjct: 912  NSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVD-----CEET 966

Query: 1810 ERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRR--RLEEQAAQHKA 1867
             + + +K   +                 E+  +  R LA   A QR+   LE   A  +A
Sbjct: 967  SKWITDKTKVV-----------------ESTKDLGRDLAGIIAIQRKLSGLERDVAAIQA 1009

Query: 1868 DIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELG 1927
             ++    + ++  DS  E++    ED  ++++ +EE    L    +++  G+ +L  E+ 
Sbjct: 1010 RVDALERESQQLMDSHPEQK----EDIGQRQKHLEE----LWQGLQQSLQGQEDLLGEVS 1061

Query: 1928 RIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALE 1987
            ++++  +D      QA L +  Q+ +A+E+          + +SL   E+  +Q     +
Sbjct: 1062 QLQAFLQDL--DDFQAWL-SITQKAVASED----------MPESLPEAEQLLQQHAGIKD 1108

Query: 1988 EVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQA------------EEKAHAFA 2035
            E++      +  +R++E  E+    Q         +RL+             E ++H  A
Sbjct: 1109 EID---GHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLA 1165

Query: 2036 VQQKEQELQQTLQQEQSVLDQLR---------GEAEAARRAAEEAEEARVQAEREAAQSR 2086
                 QE Q+  +Q +++L                EAA     + E+     E    +  
Sbjct: 1166 QCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVL 1225

Query: 2087 RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEME 2146
              V+   +L       A+    +    EK++   ++      +A++A++  +   + +  
Sbjct: 1226 SPVDSGNKL------VAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQ-- 1277

Query: 2147 KHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEE 2206
                F +        +  +L T   Q    D  +NL ++ L+  +A   E A     +E 
Sbjct: 1278 ---NFLQNCQELTLWINDKLLT--SQDVSYDEARNLHNKWLKH-QAFVAELASHEGWLEN 1331

Query: 2207 ELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQ 2266
                 +  M+E  +  A +  +  AL  R  D  Q   +E+ + +        RL   A 
Sbjct: 1332 IDAEGKQLMDEKPQFTALVSQKLEAL-HRLWDELQATTKEKTQHLSAARSSDLRLQTHAD 1390

Query: 2267 ----EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQ 2320
                 +A   QL  +D  +      +ML  K++ V++   ++ E   EL  Q   +  E+
Sbjct: 1391 LNKWISAMEDQLRSDDPGKDLTSVNRML-AKLKRVEDQVNVRKEELGELFAQVPSMG-EE 1448

Query: 2321 ARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAE-- 2378
                    E+    L E     ++ LE+ R + L++S + E   L V E       A+  
Sbjct: 1449 GGDADLSIEKRFLDLLEPLGRRKKQLESSRAK-LQISRDLEDETLWVEERLPLAQSADYG 1507

Query: 2379 ---EDAQRFRKQAEEIGEKL----HRTELATQEKVTLVQTLEIQRQQSDH-------DAE 2424
               +  Q F K+ + +  ++     R E   Q    LV+  EI  Q  +          +
Sbjct: 1508 TNLQTVQLFMKKNQTLQNEILGHTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWD 1567

Query: 2425 RLREAIA-ELEREKEKLQQEAKLLQLKSEEMQTVQQEQLL----QETQALQQSFLSEKDS 2479
            RLREA A  L+R ++    EA+   L ++E +    EQ L     E    ++  +     
Sbjct: 1568 RLREAAAGRLQRLRD--ANEAQQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR 1625

Query: 2480 LLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE 2539
             L+++R +E     ++QL     ++AQ L      + +Q+     RL   +++      +
Sbjct: 1626 HLRQQRAVEDYGRNIKQL----ASRAQGLLSAGHPEGEQI----IRLQGQVDKHYAGLKD 1677

Query: 2540 AEEGVRRKQEELQQLEQQRRQQEEL 2564
              E  +RK E +  L Q +R+ ++L
Sbjct: 1678 VAEERKRKLENMYHLFQLKRETDDL 1702



 Score = 77.8 bits (190), Expect = 2e-13
 Identities = 213/1016 (20%), Positives = 411/1016 (40%), Gaps = 105/1016 (10%)

Query: 1650 EARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL 1709
            E +R GK  + A+        E EK  +   G A   L   ++ I +    +        
Sbjct: 286  EGKRVGKVIDHAI--------ETEKMIEKYSGLASDLLTWIEQTITVLNSRK-------- 329

Query: 1710 LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLL---ASKARAEEESRSTSEKSKQR 1766
                L  +Q++  A +  R   +    + +  +EVLL    S+ RA  +   T    K  
Sbjct: 330  FANSLTGVQQQLQAFSTYRTVEKPPKFQEKGNLEVLLFTIQSRMRANNQKVYTPHDGK-- 387

Query: 1767 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRL 1826
            L ++  R  E  EEA   R LA   +  RQ   E  AR+    +R  A +   + E  RL
Sbjct: 388  LVSDINRAWESLEEAEYRRELALRNELIRQEKLEQLARR---FDRKAAMRETWLSENQRL 444

Query: 1827 KTEAEIA--LKEKEAENERLRRLAEDEAFQRRR---LEEQAAQHKADIEERLAQLRKASD 1881
              +      L   EA  ++   +  D A    R   LE+ A + + +      ++    D
Sbjct: 445  VAQDNFGYDLAAVEAAKKKHEAIETDTAAYEERVRALEDLAQELEKENYHDQKRITARKD 504

Query: 1882 SELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG-------KAEL-ELELGRIRSNA 1933
            + L R    +++ L+ RRQ  E  LAL+  F+            KA L   E G+     
Sbjct: 505  NIL-RLWSYLQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEV 563

Query: 1934 EDTLRSKEQAELEAARQR-QLAAEEERRRREAEERVQKSLAAE--EEAARQRKAALEEVE 1990
            ED L+  +  E + A Q  ++ A      +  E +  +    +  ++     +   EE+ 
Sbjct: 564  EDLLQKHKLMEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELS 623

Query: 1991 RL----KAKVEEARRLRERA-EQESARQLQLAQEAAQKRLQ-AEEKAHAFAVQQKEQELQ 2044
             +    KA++E+++RL +   E + A      +E     L   ++      +Q+K +  +
Sbjct: 624  NMAAGRKAQLEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFE 683

Query: 2045 QTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEE 2101
              L+   + L+Q+  EA    A ++      EAR+   +E +    Q+++     +   +
Sbjct: 684  DELRGLDAHLEQIFQEAHGMVARKQFGHPQIEARI---KEVSAQWDQLKDLAAFCKKNLQ 740

Query: 2102 QAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKA- 2160
             A+   Q Q  A+ L K   Q+A R    E    + + A  A  +KHK F E+    +  
Sbjct: 741  DAENFFQFQGDADDL-KAWLQDAHRLLSGEDVG-QDEGATRALGKKHKDFLEELEESRGV 798

Query: 2161 --QVEQELTTLRLQLEETD---HQKNLLDEELQRLKAEATEAARQRSQVEEELFSV---- 2211
               +EQ+      +  ++    H+   L E  Q++ A+A +  +QR Q   +L++V    
Sbjct: 799  MEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQA-DLRQQRLQEALDLYTVFGET 857

Query: 2212 ---RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEA 2268
                + M E  K  A +E  +    L D +  Q       ++MK +  +   +++AA   
Sbjct: 858  DACELWMGEKEKWLAEMEMPDT---LEDLEVVQHRFDILDQEMKTLMTQIDGVNLAANSL 914

Query: 2269 A-----RLRQLAE--EDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2321
                  R R++ +  + L  +    + ++ E+ +AV  A R+       ++  +   ++ 
Sbjct: 915  VESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETSKWITDKT 974

Query: 2322 RRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDA 2381
            + ++  K+ + + LA      QR L    +    + A  + L+    ++  +    +ED 
Sbjct: 975  KVVESTKD-LGRDLAGII-AIQRKLSGLERDVAAIQARVDALERESQQLMDSHPEQKEDI 1032

Query: 2382 QRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERL---REAIAELEREKE 2438
             + +K  EE+ + L ++    ++ +  V  L+   Q  D     L   ++A+A  E   E
Sbjct: 1033 GQRQKHLEELWQGLQQSLQGQEDLLGEVSQLQAFLQDLDDFQAWLSITQKAVAS-EDMPE 1091

Query: 2439 KLQQEAKLLQ----LKSEEMQTVQQEQLLQET--QALQQSFLSEKDSLLQRERFIEQEKA 2492
             L +  +LLQ    +K E        Q ++E+  + +Q     E   L QR   ++    
Sbjct: 1092 SLPEAEQLLQQHAGIKDEIDGHQDSYQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWN 1151

Query: 2493 KLEQLFQDEVAKAQQLREEQQRQQQQMEQE----RQRLVASMEEARRRQHEAEEGVRRKQ 2548
             L ++++       Q    Q+ Q+   + E     Q    +  E       AE G+R+ +
Sbjct: 1152 ALGRMWESRSHTLAQCLGFQEFQKDAKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFE 1211

Query: 2549 EELQQLEQQRRQQ-------EELLAEEN---QRLREQLQLLEEQHRAALAHSEEVT 2594
            + L  +E  R +         +L+AE N    +++E++QL+E++HR     ++E +
Sbjct: 1212 DFLGSMENNRDKVLSPVDSGNKLVAEGNLYSDKIKEKVQLIEDRHRKNNEKAQEAS 1267



 Score = 75.1 bits (183), Expect = 1e-12
 Identities = 173/791 (21%), Positives = 330/791 (41%), Gaps = 107/791 (13%)

Query: 1923 ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEE----ERRRREAEERVQKSLAAEEEA 1978
            E E  R  +   + +R ++  +L     R+ A  E    E +R  A++     LAA E A
Sbjct: 401  EAEYRRELALRNELIRQEKLEQLARRFDRKAAMRETWLSENQRLVAQDNFGYDLAAVEAA 460

Query: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE----KAHAF 2034
             ++ +A    +E   A  EE    R RA ++ A++L+      QKR+ A +    +  ++
Sbjct: 461  KKKHEA----IETDTAAYEE----RVRALEDLAQELEKENYHDQKRITARKDNILRLWSY 512

Query: 2035 ---AVQQKEQELQQTLQQEQSVLDQLRG--EAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
                +Q + Q L+ TL  ++   D L      +  +     AE  +   E E    + ++
Sbjct: 513  LQELLQSRRQRLETTLALQKLFQDMLHSIDWMDEIKAHLLSAEFGKHLLEVEDLLQKHKL 572

Query: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAA--RRAQAEQAALRQKQAA---DAE 2144
             EA+   Q  + +A   A  +    K  +  + +    R +  EQ        A    A+
Sbjct: 573  MEADIAIQGDKVKAITAATLKFTEGKGYQPCDPQVIQDRISHLEQCFEELSNMAAGRKAQ 632

Query: 2145 MEKHKKF---------AEQTLRQKAQVEQEL-------TTLRLQLEETDHQKNL--LDEE 2186
            +E+ K+          AE  +++K Q+   L       + L LQ +    +  L  LD  
Sbjct: 633  LEQSKRLWKFFWEMDEAESWIKEKEQIYSSLDYGKDLTSVLILQRKHKAFEDELRGLDAH 692

Query: 2187 LQRLKAEATEAARQRS----QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
            L+++  EA     ++     Q+E  +  V  Q ++L  L A  +       L+D +N  +
Sbjct: 693  LEQIFQEAHGMVARKQFGHPQIEARIKEVSAQWDQLKDLAAFCKKN-----LQDAENFFQ 747

Query: 2243 FLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2302
            F Q +A+ +K   ++A RL            L+ ED+ Q       + K+    ++E   
Sbjct: 748  F-QGDADDLKAWLQDAHRL------------LSGEDVGQDEGATRALGKKHKDFLEELEE 794

Query: 2303 LKAEAELLQQQKELAQEQAR-------RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLE 2355
             +   E L+QQ +   E+ R       RLQ  +E   Q +A+     QR  EA       
Sbjct: 795  SRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEA--LDLYT 852

Query: 2356 MSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQ 2415
            +  E +  +L + E  +  A  E          E++    HR ++  QE  TL+  ++  
Sbjct: 853  VFGETDACELWMGEKEKWLAEME-----MPDTLEDLEVVQHRFDILDQEMKTLMTQIDGV 907

Query: 2416 RQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ----Q 2471
               ++   E       E+++ ++ L    +  Q    E +      L      +      
Sbjct: 908  NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQTLVSERREAVDSALRVHNYCVDCEETS 967

Query: 2472 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASME 2531
             ++++K  +++  + + ++ A +  + Q +++  ++     Q +   +E+E Q+L+ S  
Sbjct: 968  KWITDKTKVVESTKDLGRDLAGIIAI-QRKLSGLERDVAAIQARVDALERESQQLMDSHP 1026

Query: 2532 EARRRQHEAEEGVRRKQ-EEL-QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAH 2589
            E +      + G R+K  EEL Q L+Q  + QE+LL E +Q L+  LQ L++  +A L+ 
Sbjct: 1027 EQKE-----DIGQRQKHLEELWQGLQQSLQGQEDLLGEVSQ-LQAFLQDLDD-FQAWLSI 1079

Query: 2590 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2649
            +++  AS+    ++LP     L      A  +   DG   + S QR++E+G       ++
Sbjct: 1080 TQKAVASE-DMPESLPEAEQLLQ---QHAGIKDEIDG--HQDSYQRVKESG-------EK 1126

Query: 2650 LAQGHTTVDEL 2660
            + QG T  + L
Sbjct: 1127 VIQGQTDPEYL 1137



 Score = 74.3 bits (181), Expect = 3e-12
 Identities = 302/1499 (20%), Positives = 557/1499 (37%), Gaps = 179/1499 (11%)

Query: 1010 EVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTI 1069
            E+ GL   + ++  EA  ++A  +     P + + ++    + +Q++ L+A   + L+  
Sbjct: 685  ELRGLDAHLEQIFQEAHGMVARKQFGH--PQIEARIKEVSAQWDQLKDLAAFCKKNLQDA 742

Query: 1070 SLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRD 1129
                +  QG  + L+A  +      +      +  AT+A  KK +   E  +        
Sbjct: 743  ENFFQ-FQGDADDLKAWLQDAHRLLSGEDVGQDEGATRALGKKHKDFLEELE-------- 793

Query: 1130 ELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRY 1189
            E RG  E  E+  Q   E   +      R+  L E +Q V+AQ D+RQ+ L++       
Sbjct: 794  ESRGVMEHLEQQAQGFPEEFRDSPDVTHRLQALRELYQQVVAQADLRQQRLQEALDLYTV 853

Query: 1190 YRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRF 1249
            + E+ D    W+ +   +++ +  M + D+             LE++E            
Sbjct: 854  FGET-DACELWMGE---KEKWLAEMEMPDT-------------LEDLE------------ 884

Query: 1250 AKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSG---SESVIQEYVDLRTHYSELTT 1306
              Q+   I D E++  T   Q++ V + A    V+SG   S  V Q    L T +    T
Sbjct: 885  VVQHRFDILDQEMK--TLMTQIDGV-NLAANSLVESGHPRSREVKQYQDHLNTRWQAFQT 941

Query: 1307 LTSQ-------------YIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQL 1353
            L S+             Y     ET + + ++ ++ E  +   R+ LA + A   K   L
Sbjct: 942  LVSERREAVDSALRVHNYCVDCEETSKWITDKTKVVESTKDLGRD-LAGIIAIQRKLSGL 1000

Query: 1354 AEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSE----- 1408
                A  +A+ +   +E QQ M     ++E    D  Q+++ ++E  Q L+QS +     
Sbjct: 1001 ERDVAAIQARVDALERESQQLMDSHPEQKE----DIGQRQKHLEELWQGLQQSLQGQEDL 1056

Query: 1409 ----AEIQAKAR-----QAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGEL---QAL 1456
                +++QA  +     QA  +   +    E++     + E   +Q  G + E+   Q  
Sbjct: 1057 LGEVSQLQAFLQDLDDFQAWLSITQKAVASEDMPESLPEAEQLLQQHAGIKDEIDGHQDS 1116

Query: 1457 RARAEEAEAQKRQAQEEAERL----RRQVQDESQRKRQAEVELASRVKAEAEAAREKQR- 1511
              R +E+  +  Q Q + E L    R +  D          E  S   A+    +E Q+ 
Sbjct: 1117 YQRVKESGEKVIQGQTDPEYLLLGQRLEGLDTGWNALGRMWESRSHTLAQCLGFQEFQKD 1176

Query: 1512 -----ALQALEELRLQAEEAERRLRQAE--VERARQVQVALETAQRSAEAELQSKRASFA 1564
                 A+ + +E  L   E    L  AE  + +      ++E  +    + + S     A
Sbjct: 1177 AKQAEAILSNQEYTLAHLEPPDSLEAAEAGIRKFEDFLGSMENNRDKVLSPVDSGNKLVA 1236

Query: 1565 EKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQ---LKANEALR 1621
            E     ++ ++E+   +     +   +AQ+ +   R   E +  L+  Q   L  N+ L 
Sbjct: 1237 EGNLYSDK-IKEKVQLIEDRHRKNNEKAQEASVLLRDNLELQNFLQNCQELTLWINDKL- 1294

Query: 1622 LRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1681
            L  Q     + ++L     + Q   AE  A   G  E      ++L    ++++ Q    
Sbjct: 1295 LTSQDVSYDEARNLHNKWLKHQAFVAEL-ASHEGWLENIDAEGKQL----MDEKPQFTAL 1349

Query: 1682 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA----AATQKRQELEAELAK 1737
             +Q+  A  +    L+A T++  Q          RLQ  A      +  + Q    +  K
Sbjct: 1350 VSQKLEALHRLWDELQATTKEKTQHLSAARSSDLRLQTHADLNKWISAMEDQLRSDDPGK 1409

Query: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLE-----AEAGRFRELAEEAARLRALAEEAK 1792
                +  +LA   R E++     E+  +         E G   +L+ E   L  L    +
Sbjct: 1410 DLTSVNRMLAKLKRVEDQVNVRKEELGELFAQVPSMGEEGGDADLSIEKRFLDLLEPLGR 1469

Query: 1793 RQRQLAEEDAARQRA---EAERVLAEKLAAIGEA----TRLKTEAEIALKEKEAENERLR 1845
            R++QL    A  Q +   E E +  E+   + ++    T L+T      K +  +NE L 
Sbjct: 1470 RKKQLESSRAKLQISRDLEDETLWVEERLPLAQSADYGTNLQTVQLFMKKNQTLQNEILG 1529

Query: 1846 RL--AEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEE 1903
                 ED   + ++L E A     D+EERL  L+ + D   E   G ++   R R   E 
Sbjct: 1530 HTPRVEDVLQRGQQLVEAAEIDCQDLEERLGHLQSSWDRLREAAAGRLQ---RLRDANEA 1586

Query: 1904 EILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRRE 1963
            +   L A   +A  G+ EL +    I  + E  +   ++      RQ++   +  R  ++
Sbjct: 1587 QQYYLDADEAEAWIGEQELYVISDEIPKDEEGAIVMLKR----HLRQQRAVEDYGRNIKQ 1642

Query: 1964 AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2023
               R Q  L+A      Q      +V++  A +++    R+R  +      QL +E    
Sbjct: 1643 LASRAQGLLSAGHPEGEQIIRLQGQVDKHYAGLKDVAEERKRKLENMYHLFQLKRETDDL 1702

Query: 2024 RLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEA-EAARRAAEEAEEARVQAER-- 2080
                 EK     +     E+ Q       + D+ R  A E      E  +      ER  
Sbjct: 1703 EQWISEK----ELVASSPEMGQDFDHVTLLRDKFRDFARETGAIGQERVDNVNAFIERLI 1758

Query: 2081 -----EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRK--EAEQEAARRAQAEQA 2133
                 EAA      +    +     E    R Q  AA+  L +      E       +  
Sbjct: 1759 DAGHSEAATIAEWKDGLNEMWADLLELIDTRMQLLAASYDLHRYFYTGAEILGLIDEKHR 1818

Query: 2134 ALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE 2193
             L +    DA        AE   R     E+EL  L +Q+++       L       KAE
Sbjct: 1819 ELPEDVGLDAST------AESFHRVHTAFERELHLLGVQVQQFQDVATRLQTAYAGEKAE 1872

Query: 2194 ATE----------------AARQRSQVEE-----ELFSV-RVQMEELSKLKARIEAENRA 2231
            A +                 A +R+Q+ +       FS+ R  +  +  +  +IE + R 
Sbjct: 1873 AIQNKEQEVSAAWQALLDACAGRRTQLVDTADKFRFFSMARDLLSWMESIIRQIETQERP 1932

Query: 2232 LILRDKDNTQRFLQE-EAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEK 2288
              +   +   ++ Q   AE   +    +A L +      R  Q +EE  +  QQ     K
Sbjct: 1933 RDVSSVELLMKYHQGINAEIETRSKNFSACLELGESLLQRQHQASEEIREKLQQVMSRRK 1992

Query: 2289 MLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
             + EK +A  E  RL+   E+ Q  ++ +  +A  + ++    +          ++ ++ 
Sbjct: 1993 EMNEKWEARWE--RLRMLLEVCQFSRDASVAEAWLIAQEPYLASGDFGHTVDSVEKLIKR 2050

Query: 2349 ERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVT 2407
                +   ++ AER     A + +      ++ Q   + AEE G +    E A +  V+
Sbjct: 2051 HEAFEKSTASWAERF----AALEKPTTLELKERQIAERPAEETGPQEEEGETAGEAPVS 2105


>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
          Length = 3639

 Score =  358 bits (920), Expect = 5e-98
 Identities = 660/2892 (22%), Positives = 1152/2892 (39%), Gaps = 414/2892 (14%)

Query: 11   ISSLKDERDRVQKKTFTKWVNKHLIKAQRHIS--DLYEDLRDGHNLISLLEVLSGDSLPR 68
            I  L+    ++Q+KTFTKW+N      Q  I   +LY +L DG +L+ LLE++SG++LP 
Sbjct: 10   IRKLQARHMQMQEKTFTKWINNVFQCGQAGIKIRNLYTELADGIHLLRLLELISGEALPP 69

Query: 69   -EKGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI 127
              +GR+R H L+N   AL +LR + V +  I  ++I DG+  L LGLIW IIL FQIS I
Sbjct: 70   PSRGRLRVHFLENSSRALAFLRAK-VPVPLIGPENIVDGDQTLILGLIWVIILRFQISHI 128

Query: 128  QVSGQSEDMTA-----KEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLL 182
             +  +    +A     KE LL+W QR    Y  +   +F+ SW DG  FNA+IH H+P L
Sbjct: 129  SLDKEEFGASAALLSTKEALLVWCQRKTASYTNVNITDFSRSWSDGLGFNALIHAHRPDL 188

Query: 183  IDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPR 242
            +D   +     L NL  AF VAE++LG+ +LLDPEDV   QPDE+SI+TYVS  Y    R
Sbjct: 189  LDYGSLRPDRPLHNLAFAFLVAEQELGIAQLLDPEDVAAAQPDERSIMTYVSLYYHYCSR 248

Query: 243  VPDVQDGVR--------ANELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEI 294
            +   Q   R          E +L   +Y +LV  LL+W+       E R FP S   +  
Sbjct: 249  LHQGQTVQRRLTKILLQLQETELLQTQYEQLVADLLRWIAEKQMQLEARDFPDSLPAMRQ 308

Query: 295  LWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKVP----PGYHPLDVEKEWGK 350
            L + F  F+  E P +   +  ++ +   L+ A+QA Q + P     G    ++ + W  
Sbjct: 309  LLAAFTIFRTQEKPPRLQQRGAAEALLFRLQTALQA-QNRRPFLPHEGLGLAELSQCWAG 367

Query: 351  LHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQS----DVRLLAA 406
            L  A   R + L+    +L+ L+ +  + Q +A L E  L  A+ +L         L   
Sbjct: 368  LEWAEAARSQALQQRLLQLQRLETLARRFQHKAALRESFLKDAEQVLDQARAPPASLATV 427

Query: 407  GKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEY 466
                QR G +E  +   +   + L      L+  ++     + RR     +  V +R + 
Sbjct: 428  EAAVQRLGMLEAGILPQEGRFQALAEIADILRQEQYHSWADVARR-----QEEVTVRWQ- 481

Query: 467  NLRLKAGVAAPATQVAQV-TLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVD 525
              RL   +     QVA +  + S+ +  E     L  LQ+        Q   +  E    
Sbjct: 482  --RLLQHLQGQRKQVADMQAVLSLLQEVEAASHQLEELQEPARSTACGQQLAEVVELLQR 539

Query: 526  LPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNS 585
               +EAQ+ +H      + +  A+++ +     ++  A        L +L      L+ +
Sbjct: 540  HDLLEAQVSAHGAHVSHLAQQTAELDSSLGTSVEVLQAKART----LAQLQQSLVALVRA 595

Query: 586  SKARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 645
             +A L        F+    +E  WL E  +           + +    + + AL  E+  
Sbjct: 596  RRALLEQTLQRAEFLRNCEEEEAWLKECGQRVGNAALGRDLSQIAGALQKHKALEAEVHR 655

Query: 646  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 705
             +    +L   G  L     P +P       A+Q  W  +        A L+      Q+
Sbjct: 656  HQAVCVDLVRRGRDLSARRPPTQPDPGERAEAVQGGWQLLQTRVVGRGARLQTALLVLQY 715

Query: 706  FSDVREAEGQLQKLQEALRRKYSC--DRSATVT------RLEDLLQDAQDEKEQLNEYKG 757
            F+D  EA   L++ + +L R  SC  D++A  T      RLE +L+    E  +L E   
Sbjct: 716  FADAAEAASWLRERRSSLERA-SCGQDQAAAETLLRRHVRLERVLRAFAAELRRLEEQGR 774

Query: 758  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 817
              S  A        L P  P   +R   P      + +       GD  ++  PA+P   
Sbjct: 775  AASARASLFTVNSALSP--PGESLRNPGP------WSEASCHPGPGDAWKMALPAEPD-- 824

Query: 818  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 877
                        P      P    + Q+ +++     +AL  L      +  +L  + S 
Sbjct: 825  ------------PD---FDPNTILQTQDHLSQDYESLRALAQLRRARLEEAMALFGFCSS 869

Query: 878  RRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAE---R 934
              ++QL         + ++P  Q   L  ++L Y+ FL       G   E    AE   +
Sbjct: 870  CGELQLWLEKQTVLLQRVQP--QADTLEVMQLKYENFLTALAVGKGLWAEVSSSAEQLRQ 927

Query: 935  EYGSCSHHYQQLLQSLEQ--GAQEESRCQRCIS-------------------ELKDIRLQ 973
             Y   S   Q+  + L Q  G  E  + ++ +                    +L+D+ LQ
Sbjct: 928  RYPGNSTQIQRQQEELSQRWGQLEALKREKAVQLAHSVEVCSFLQECGPTQVQLRDVLLQ 987

Query: 974  LEACE----TRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1029
            LEA +      T H L+L   K    E  +R+   Q    +VE                 
Sbjct: 988  LEALQPGSSEDTCHALQLAQKKTLVLE--RRVHFLQSVVVKVE----------------- 1028

Query: 1030 ALPEPSPA-APTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEE 1088
               EP  A +  L+ ++E   G L+QV+                       E+V +    
Sbjct: 1029 ---EPGYAESQPLQGQVETLQGLLKQVQ-----------------------EQVAQRARR 1062

Query: 1089 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1148
            Q  E QA  + L E +      + ++AQ  +++ + D             +RL + H + 
Sbjct: 1063 Q-AETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVAS---------AQRLLREHQDL 1112

Query: 1149 DVEVERWRERVAQLLERWQAVLAQTDVRQRE----LEQLGRQLRYYRESADPLGAWLQDA 1204
              E+  W+ER+ QL  + Q + A      +E    L  LG+Q +  +   +    WLQ+ 
Sbjct: 1113 LEEIHLWQERLQQLDAQSQPMAALDCPDSQEVPNTLRVLGQQGQELKVLWEQRQQWLQEG 1172

Query: 1205 RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQL 1264
               Q+  +     +           QA L  ++  GE V E     +Q+    +++   L
Sbjct: 1173 LELQKFGR-----EVDGFTATCANHQAWL-HLDNLGEDVREALSLLQQH----REFGRLL 1222

Query: 1265 VTYKAQLEPVASPAKKPKVQS---GSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR 1321
             T   + E + +  +K  VQS    + +V ++   ++  ++ L   + Q  + +  +L+ 
Sbjct: 1223 STLGPRAEALRAHGEK-LVQSQHPAAHTVREQLQSIQAQWTRLQGRSEQRRRQLLASLQL 1281

Query: 1322 MEEEERLAE-QQRAEERERLA--EVEAALEKQRQLAEAHAQAKAQ--AEREAKELQQRMQ 1376
             E ++ +AE  Q  EE+  +A  E   A     Q  + H  A+++  A R   E  Q++ 
Sbjct: 1282 QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVG 1341

Query: 1377 EEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVR 1436
             E++ R          +  IQ  LQ LR   EA  +    + +  +++            
Sbjct: 1342 RELLSRRPCG------QEDIQTRLQGLRSKWEALNRKMTERGDELQQAG----------- 1384

Query: 1437 LQLEATERQRGGAEGELQALRARAEEAE-AQKRQAQEEAERLRRQVQDESQ---RKRQAE 1492
             Q E   RQ   A+ +L+ L    + +E  Q  ++ +  ++  +Q++ ES+    K  A 
Sbjct: 1385 -QQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQRLQKRHQQLESESRTLAAKMAAL 1443

Query: 1493 VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLR-QAEVERARQVQVALETAQRS 1551
              +A  + A      E Q+ L+ LE   LQ   A R L+ QA VE  +   ++       
Sbjct: 1444 ASMAHGMAASPAILEETQKHLRRLE--LLQGHLAIRGLQLQASVELHQFCHLSNMELSWV 1501

Query: 1552 AEAELQSKRASFAE---KTAQLERSLQEEHVAVAQLREEAER--------RAQQQAEAER 1600
            AE        S+ E       L R  +E  V V   + + +R         A    +A+ 
Sbjct: 1502 AEHMPHGSPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQH 1561

Query: 1601 AREEAERELERWQ--LKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAE 1658
              E+ +     W    +A EA    LQ     QQ  L  +E E   EE       R    
Sbjct: 1562 IVEQCQELEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEEKRPLVSSRDYGR 1621

Query: 1659 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ 1718
            ++A   R + + +  ++      ++ + L    + +      EQ    ++ L E+L  LQ
Sbjct: 1622 DEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRALQ 1681

Query: 1719 REAAAATQKRQELEA-----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEA 1771
              AA    + +ELE      E  +   +++  LAS+ +A +   S  E  +  L    + 
Sbjct: 1682 ELAAT---RDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKF 1738

Query: 1772 GRFR---ELAEEAARLRALAEEAKRQRQLAEEDAARQRAE----AERVLAEKLAAIGEAT 1824
             +F+   E+  +      L  E+  +R  +     RQR +    A   L E   A G A 
Sbjct: 1739 AKFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHAL 1798

Query: 1825 RLKTEAEIALKEKEAE-----NERLRRLAEDEAFQRRRLEEQAAQHK------ADIEERL 1873
            R  TE  + +     E      E+   L  + A     LE Q   H+         E +L
Sbjct: 1799 R-DTETTLRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQL 1857

Query: 1874 AQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNA 1933
             +L + +    +   G     ++QR+Q   +  A+     +    + E    L R R+  
Sbjct: 1858 QELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAV 1917

Query: 1934 ED----TLRSKEQAELEAARQ------------RQLAAEEERRRREAEERVQKSLAAEEE 1977
             D      R ++  ++E + Q            + L AE E R +  ++  Q    A   
Sbjct: 1918 RDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLA 1977

Query: 1978 AARQRKAALEEVERLKAKVEEA----RRLRERAEQESARQLQLAQEAAQKRLQA--EEKA 2031
            A    K   EE+  L+ + ++      R +ER + E   QL L +    + + A  E   
Sbjct: 1978 AGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSL 2037

Query: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAE---AARRAAEEAEEARVQAE--------- 2079
               A+    +E++Q +++ +  L  L  + +   A R   +     RV+           
Sbjct: 2038 KTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRM 2097

Query: 2080 --REAAQSRRQVEEAERLKQSAEEQA-QARAQAQAAAEKLRKEAEQEAARRAQAEQAALR 2136
              +E A+SR     A  L  S  + A QA    QA A++L++       R    +   L 
Sbjct: 2098 RVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLR---DKLKPLL 2154

Query: 2137 QKQAADAEMEKHK-------KFAEQTLRQK----AQVEQELTTLR-----------LQLE 2174
            + QA +AE++ H+       K  E  L Q      +V Q L  LR           L+ +
Sbjct: 2155 KHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQ 2214

Query: 2175 ETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARI--------- 2225
            E + ++N L E LQR+  +  EA  Q  +V+  +  +   +E   +L+ R+         
Sbjct: 2215 ELEDRRNFL-EFLQRV--DLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAG 2271

Query: 2226 EAENRALILRDKDNTQRFLQEEAEKMK------------------------QVAEEAARL 2261
            +    A I    D + +    + E++K                        Q  E A  +
Sbjct: 2272 DTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEI 2331

Query: 2262 SVAAQEAARLRQLAEEDLAQQRAL--------AEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
             V ++E   + +  +E  A  +AL         +++L++  +  +E   ++A+ E L+++
Sbjct: 2332 HVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVESLERE 2391

Query: 2314 K----ELAQEQARRLQEDKEQMAQ---QLAEETQGFQRTLEAERQRQ------LEMSAEA 2360
                 + + E A  L+  ++++A+   QL    Q  +  L+A  Q Q       E+   A
Sbjct: 2392 VGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLVSA 2451

Query: 2361 ERLKLRVAEMSRAQA-RAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQS 2419
            +RL+   A+M  + A R+  +A+R  ++ +E   +L     +  + ++L ++   Q   +
Sbjct: 2452 QRLR---AQMDTSPAPRSPVEARRMLEEHQECKAELD----SWTDSISLARSTGQQLLTA 2504

Query: 2420 DHD-AERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-QSFLSEK 2477
             H  +  +R+ +A LE+E   L              +   QE  LQ  QAL+ Q FLS  
Sbjct: 2505 GHPFSSDIRQVLAGLEQELSSL--------------EGAWQEHQLQLQQALELQLFLS-- 2548

Query: 2478 DSLLQRERFI-EQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRR 2536
             S+ + ER++  +E +   +   D +A  + L  + +  +  +E +  + ++++E   R 
Sbjct: 2549 -SVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGK-ISALEATARG 2606

Query: 2537 QHEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTAS 2596
             H+   G    Q  L + +    ++E L  +   R R +L+ L  Q +A L  S+EV A+
Sbjct: 2607 LHQG--GHPEAQSALGRCQAMLLRKEALFRQAGTR-RHRLEEL-RQLQAFLQDSQEV-AA 2661

Query: 2597 QVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ---- 2652
             +     +      LD     A+       L+++ + Q   +A +   +ELQR  Q    
Sbjct: 2662 WLREKNLVALEEGLLDTAMLPAQ-------LQKQQNFQAELDASMHQQQELQREGQRLLQ 2714

Query: 2653 -GHTTVDELARR 2663
             GH   + +  R
Sbjct: 2715 GGHPASEAIQER 2726



 Score =  179 bits (454), Expect = 6e-44
 Identities = 467/2118 (22%), Positives = 814/2118 (38%), Gaps = 368/2118 (17%)

Query: 403  LLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAI 462
            L  A  + ++  E++ ++      ++ + +  ++L    HPQ + +  +   L      +
Sbjct: 1517 LNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELEGHWAEL 1576

Query: 463  RTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEW 522
                  R            AQ   Q+V  +    D     + +L  WVEE +  V   ++
Sbjct: 1577 ERACEAR------------AQCLQQAVTFQQYFLD-----VSELEGWVEEKRPLVSSRDY 1619

Query: 523  GVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLS-PATRGAYRDCLGRLDLQYAK 581
            G D  +    +  H+ L + +  + + +E        L+ P      R    RL  Q   
Sbjct: 1620 GRDEAATLRLINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRA 1679

Query: 582  LLNSSKARLRSLES---LHSFVAAATKELMWL-NEKEEEEVGFDWSDRNTNMTAKKESYS 637
            L   +  R R LE    LH F+  A     WL ++K+  + G    +   +       ++
Sbjct: 1680 LQELAATRDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739

Query: 638  ALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLK 697
                ++E+  +++   +   + LL   H A P V   Q  LQT WS + +L         
Sbjct: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELT-------- 1791

Query: 698  ENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKG 757
                         +A G       ALR     D   T+    DLL+     +E+      
Sbjct: 1792 -------------QARGH------ALR-----DTETTLRVHRDLLEVLTQVQEKATSL-- 1825

Query: 758  HLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHW 817
                            P + A  + G           + ++  H+G E +LVG  +    
Sbjct: 1826 ----------------PNNVARDLCGL----------EAQLRSHQGLERELVGTERQLQ- 1858

Query: 818  KVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSL 877
            ++L ++G    V  +C     P  +A     R +A  QA   L  ++      L   + L
Sbjct: 1859 ELLETAGR---VQKLC-----PGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLL 1910

Query: 878  RRDVQLIR---SWSLATFRTLKPEEQRQALHS--LELHYQAFLRDSQDAGGFGPEDRLMA 932
             R    +R   SW+    + L+ EE  Q   S  L+L    +LR   +A           
Sbjct: 1911 ARFRTAVRDYASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEA----------R 1960

Query: 933  EREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKE 992
            E+ +   +   QQ L +     +E    Q  +  L+D R Q+     R   RL+    ++
Sbjct: 1961 EKLWQQATQLGQQALLAAGTPTKE---VQEELRALQDQRDQVYQTWARKQERLQAEQQEQ 2017

Query: 993  P-ARECA--QRIAEQQKAQAEVEGLGKGVAR--------------LSAEAEKVLALPE-- 1033
               REC   + I   Q+   +   LG  V                L+A+ +K  AL E  
Sbjct: 2018 LFLRECGRLEEILAAQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERL 2077

Query: 1034 PSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGA---EEVLRAHEEQL 1090
             +   P +R  L + L +  +V+ L+      L    L+   TQ A   E+ ++A  +QL
Sbjct: 2078 KTLRRPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQL 2137

Query: 1091 KEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDV 1150
            KE    P  L +    K  LK    +AE Q     A  + +    + GE L  +   R  
Sbjct: 2138 KEP-VPPGDLRD--KLKPLLKHQAFEAEVQ-----AHEEVMTSVAKKGEALLAQSHPRAG 2189

Query: 1151 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDA------ 1204
            EV    +R+  L + W+ +     +R +ELE   R    + +  D   AW+Q+       
Sbjct: 2190 EVS---QRLQGLRKHWEDLRQAMALRGQELEDR-RNFLEFLQRVDLAEAWIQEKEVKMNV 2245

Query: 1205 -------------RRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEE-CQRFA 1250
                         RRR  + +     D+             L+   R  E+V+  CQR  
Sbjct: 2246 GDLGQDLEHCLQLRRRLREFRGNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQR-R 2304

Query: 1251 KQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310
             Q  N    +   L+ Y+ QLE         +        IQE   L            +
Sbjct: 2305 SQLNNRWASFHGNLLRYQQQLEGALEIHVLSRELDNVTKRIQEKEALIQALD-----CGK 2359

Query: 1311 YIKFISETLRRMEEEER----LAEQQRAEERE--RLAE--VEAA---LEKQRQLAEAHAQ 1359
             ++ +   LR+ EE ER    +  Q  + ERE  RL +   EAA     +Q+++AE+  Q
Sbjct: 2360 DLESVQRLLRKHEELEREVHPIQAQVESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQ 2419

Query: 1360 AKAQAER---------EAKELQQRMQEEVV--RREEAAVDAQQQKRSIQEELQQLRQSSE 1408
             +++A++         +A++LQ  +QE +V  +R  A +D     RS  E  + L +  E
Sbjct: 2420 LRSRAQKRREALDALHQAQKLQAMLQELLVSAQRLRAQMDTSPAPRSPVEARRMLEEHQE 2479

Query: 1409 AEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468
             + +  +   ++   +R   ++ +           +   G E EL +L    +E + Q +
Sbjct: 2480 CKAELDS-WTDSISLARSTGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQ 2538

Query: 1469 QAQE------EAERLRRQVQDESQ-------------------RKRQAEVEL---ASRVK 1500
            QA E        E++ R +  +                     + +  E +L   A ++ 
Sbjct: 2539 QALELQLFLSSVEKMERWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKIS 2598

Query: 1501 AEAEAAR--------EKQRALQALEELRLQAEEAERRL--RQAEVERARQVQVALETAQR 1550
            A    AR        E Q AL   + + L+ E   R+   R+  +E  RQ+Q  L+ +Q 
Sbjct: 2599 ALEATARGLHQGGHPEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQE 2658

Query: 1551 SAEAELQSKRASFAEK----TAQLERSLQEEHVAVAQLREEAERRAQQQAEAER------ 1600
             A A L+ K     E+    TA L   LQ++    A+L     ++ + Q E +R      
Sbjct: 2659 VA-AWLREKNLVALEEGLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGH 2717

Query: 1601 -AREEAERELER----WQ-------------LKANEALRLRLQAEEVAQQKSLAQAE--- 1639
             A E  +  LE     W               KA EALRLR   EE+       + E   
Sbjct: 2718 PASEAIQERLEELGALWGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRA 2777

Query: 1640 ---------------AEKQKEEAEREARRRGKA---EEQA-VRQRELAEQELEKQ----- 1675
                            +++ E A  +  R+ +A   + QA VR+     Q++E+Q     
Sbjct: 2778 PTVGQALPGVGELLGTQRELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVEEQARRLL 2837

Query: 1676 ---RQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEE-ELARLQREAAAAT------ 1725
               + L E   ++R A E   + L+   +  E+   + E+  LA  Q    + +      
Sbjct: 2838 QRFKSLREPLQERRTALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQ 2897

Query: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1785
            ++ Q LE+E++   A   V+L +  +  +     + +   R++        L  EAAR R
Sbjct: 2898 EQHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRR 2957

Query: 1786 ALAEEAKRQRQLAEE--DAARQRAEAERVL-AEKLAAIGEATR-LKTEAEIALKEKEAEN 1841
             L ++A+  +Q   E  +A    AE   VL +E +    EAT+ L    E   ++ EA +
Sbjct: 2958 LLLQQAQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017

Query: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIE---ERLAQLRKASDSELERQKGLVEDTLRQR 1898
             R+ RL +  A    R   ++ +  A ++   E  A+L + +++   R  GL E    Q 
Sbjct: 3018 PRIERLQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEA---RGHGLQEQL--QL 3072

Query: 1899 RQVEEEILALKASFE-KAAAGKAE---LELELGRIRSNAEDTLRSKEQA--ELEAARQRQ 1952
             Q+E E L L A    KAA  +++    +LE  ++     D  R + Q+  + +    R+
Sbjct: 3073 HQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRK 3132

Query: 1953 LAAEEERRRREAEERVQKSLAAEEEAARQR-KAALEEVER-LKAKVEEARRLRE-RAEQE 2009
            LA   ER        +Q        A R R +AA E +++ +KA+ E      E  + Q+
Sbjct: 3133 LAGTLERGAPRRYPHIQ--------AQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQ 3184

Query: 2010 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
            +A +LQ   +     ++ E+  H+ +  +  Q+  + L++E   +     E E AR   E
Sbjct: 3185 AAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAM-----EKEVARLQTE 3239

Query: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
                 ++        ++ Q E    L+  A+E+ Q  AQA      L +  E  A     
Sbjct: 3240 ACRLGQLHPAAPGGLAKVQ-EAWATLQAKAQERGQWLAQAAQGHAFLGRCQELLA----- 3293

Query: 2130 AEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQR 2189
               A  RQ+ A+  E+ +    AEQ L Q  ++ QE+   RLQ ++   +   L +    
Sbjct: 3294 --WAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRLQAQDLRQEGQQLVDNSHF 3351

Query: 2190 LKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAE 2249
            + AE TE         +EL     ++EE   L+ +  AE+  L                +
Sbjct: 3352 MSAEVTECL-------QELEGRLQELEEAWALRWQRCAESWGL----------------Q 3388

Query: 2250 KMKQVAEEAARLSVAAQEAARLR-----QLAEEDLAQQRAL-AEKMLKEKMQAVQEATRL 2303
            K++Q  E+A    +A  E   L+      +++ +L   R    EK+L  + +   +  + 
Sbjct: 3389 KLRQRLEQAEAW-LACWEGLLLKPDYGHSVSDVELLLHRHQDLEKLLAAQEEKFAQMQKT 3447

Query: 2304 KAEAELLQQQKELAQEQA 2321
            + E ELL Q +EL   +A
Sbjct: 3448 EMEQELLLQPQELKPGRA 3465



 Score =  168 bits (426), Expect = 1e-40
 Identities = 525/2412 (21%), Positives = 903/2412 (37%), Gaps = 375/2412 (15%)

Query: 480  QVAQVTLQSVQRRPELE--DSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHR 537
            QV +   Q  +R+ E +   S L+  Q LL W E  Q ++   E  VD+ S +  L  H+
Sbjct: 1051 QVQEQVAQRARRQAETQARQSFLQESQQLLLWAESVQAQLRSKEVSVDVASAQRLLREHQ 1110

Query: 538  GLHQSIEEFRAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA-KLLNSSKARLRSL--- 593
             L   +EE     ER +  + Q  P    A  DC    ++    ++L      L+ L   
Sbjct: 1111 DL---LEEIHLWQERLQQLDAQSQPM---AALDCPDSQEVPNTLRVLGQQGQELKVLWEQ 1164

Query: 594  ---------------ESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSA 638
                             +  F A       WL+    + +G D  +  + +   +E    
Sbjct: 1165 RQQWLQEGLELQKFGREVDGFTATCANHQAWLHL---DNLGEDVREALSLLQQHRE---- 1217

Query: 639  LMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKE 698
              R L     + + L+  G++L++  HPA  TV     ++Q QW+   +L    E   ++
Sbjct: 1218 FGRLLSTLGPRAEALRAHGEKLVQSQHPAAHTVREQLQSIQAQWT---RLQGRSEQRRRQ 1274

Query: 699  NAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGH 758
              A  Q   + ++   +L +  E      + + S     +   L+  +  + +L   + H
Sbjct: 1275 LLASLQL-QEWKQDVAELMQWMEEKGLMAAHEPSGARRNILQTLKRHEAAESELLATRRH 1333

Query: 759  LSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWK 818
            +  L +  + ++  +P            L +  +    ++T  +GDE Q  G  Q    +
Sbjct: 1334 VEALQQVGRELLSRRPCGQEDIQTRLQGLRSKWEALNRKMT-ERGDELQQAGQ-QEQLLR 1391

Query: 819  VLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLR 878
             L  +  +              Q+ + +  RL+ +HQ L +    L   M +L +     
Sbjct: 1392 QLQDAKEQLEQLEGALQSSETGQDLRSS-QRLQKRHQQLESESRTLAAKMAALASMAHGM 1450

Query: 879  RDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGS 938
                 I   +    R L+  +   A+  L+L  QA +   Q       E   +AE     
Sbjct: 1451 AASPAILEETQKHLRRLELLQGHLAIRGLQL--QASVELHQFCHLSNMELSWVAEHMPHG 1508

Query: 939  CSHHYQQLL---QSLEQGAQE--------ESRCQRCISELKDIRLQ--------LEACET 979
                Y + L   QSL +  +E        + + QR +S  + +           +E C+ 
Sbjct: 1509 SPTSYTECLNGAQSLHRKHKELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQE 1568

Query: 980  RTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAP 1039
               H   L    E   +C Q+    Q+   +V  L   V     +   V +       A 
Sbjct: 1569 LEGHWAELERACEARAQCLQQAVTFQQYFLDVSELEGWVEE---KRPLVSSRDYGRDEAA 1625

Query: 1040 TLRSELELTLGKLEQVRSLSAIY---LEKLKTISLVIRGTQGAEEVLRAHE---EQLKEA 1093
            TLR      + K + ++   AIY   +E+L   +  + G +  E+     E   EQL+  
Sbjct: 1626 TLR-----LINKHQALQEELAIYWSSMEELDQTAQTLTGPEVPEQQRVVQERLREQLRAL 1680

Query: 1094 QAVPATLP-ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGE------RLQQRHG 1146
            Q + AT   ELE T    + LR +AE  Q    + +   +G + +GE       L  +  
Sbjct: 1681 QELAATRDRELEGTLRLHEFLR-EAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFA 1739

Query: 1147 ERDVEVERWRERVA-------QLLER------------------WQAVLAQTDVRQRELE 1181
            +   +VE   +RVA        LLER                  W  +   T  R   L 
Sbjct: 1740 KFQHQVEMGSQRVAACRLLAESLLERGHSAGPMVRQRQQDLQTAWSELWELTQARGHALR 1799

Query: 1182 QLGRQLRYYRESADPLGAWLQDARRRQEQIQAMP---LADSQAVREQLRQEQALLEEIER 1238
                 LR +R+  + L        + QE+  ++P     D   +  QLR  Q L  E+  
Sbjct: 1800 DTETTLRVHRDLLEVL-------TQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVG 1852

Query: 1239 HGEKVEECQRFAKQYINAIKDYELQLVTYKAQ------------LEPVASPAKKPKVQSG 1286
               +++E    A +        +   V  + Q            +E   +  ++ ++ + 
Sbjct: 1853 TERQLQELLETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLAR 1912

Query: 1287 SESVIQEYV--------DLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERE 1338
              + +++Y         DL+   S     +S  +K  +    R E E R    Q+A +  
Sbjct: 1913 FRTAVRDYASWAARVRQDLQVEESSQEP-SSGPLKLSAHQWLRAELEAREKLWQQATQLG 1971

Query: 1339 RLAEVEAAL------EKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRRE----EAAVD 1388
            + A + A        E+ R L +   Q      R+ + LQ   QE++  RE    E  + 
Sbjct: 1972 QQALLAAGTPTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILA 2031

Query: 1389 AQQQKR------SIQEELQQLRQSSEAEIQAKARQ--AEAAERSRLRIEEEIRV---VRL 1437
            AQ+         S  EE++QL +  E  ++    Q   EAA R RL+     RV   + +
Sbjct: 2032 AQEVSLKTSALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPI 2091

Query: 1438 QLEATERQRGGAEGELQALRARAEEAEAQKRQAQEE------AERLRRQVQDESQRKRQA 1491
             L+   R +  AE    AL A    A   +   Q E      A++L+  V     R +  
Sbjct: 2092 LLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLK 2151

Query: 1492 EVELASRVKAEAEAAREKQRALQALEELRL-----QAEEAERRLR--QAEVERARQVQVA 1544
             +      +AE +A  E   ++    E  L     +A E  +RL+  +   E  RQ    
Sbjct: 2152 PLLKHQAFEAEVQAHEEVMTSVAKKGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAM-- 2209

Query: 1545 LETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVA--VAQLREEAERRAQQQAEAERAR 1602
               A R  E E +     F ++    E  +QE+ V   V  L ++ E   Q +      R
Sbjct: 2210 ---ALRGQELEDRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFR 2266

Query: 1603 -EEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE------REARRRG 1655
               A   +    +++   L L+L+  +  + K + Q  ++     A       R  ++  
Sbjct: 2267 GNSAGDTVGDACIRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLE 2326

Query: 1656 KAEEQAVRQREL---AEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG----EQQRQ 1708
             A E  V  REL    ++  EK+  +      + L + Q L+R   E E+     + Q +
Sbjct: 2327 GALEIHVLSRELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVE 2386

Query: 1709 LLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE 1768
             LE E+ RL + +  A    +  + E+A    E    L S+A+   E+     ++ Q+L+
Sbjct: 2387 SLEREVGRLCQRSPEAAHGLRHRQQEVA----ESWWQLRSRAQKRREALDALHQA-QKLQ 2441

Query: 1769 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1828
            A     +EL   A RLRA  + +   R   E  A R   E +   AE  +     +  ++
Sbjct: 2442 A---MLQELLVSAQRLRAQMDTSPAPRSPVE--ARRMLEEHQECKAELDSWTDSISLARS 2496

Query: 1829 EAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLA-QLRKASDSELERQ 1887
              +  L      +  +R++      +   LE    +H+  +++ L  QL  +S  ++ER 
Sbjct: 2497 TGQQLLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERW 2556

Query: 1888 KGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA 1947
                ED+L     + + +  ++    K    + +LE++ G+I S  E T R   Q     
Sbjct: 2557 LCSKEDSLASEG-LWDPLAPMEPLLWKHKMLEWDLEVQAGKI-SALEATARGLHQGGHPE 2614

Query: 1948 ARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAE 2007
            A+      +    R+EA  R   +     E  RQ +A L++ + + A + E + L    E
Sbjct: 2615 AQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLRE-KNLVALEE 2673

Query: 2008 QESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRA 2067
                  +  AQ   Q+  QAE  A     Q+ ++E Q+ LQ      + ++   E     
Sbjct: 2674 GLLDTAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGAL 2733

Query: 2068 AEEAEE------ARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQA---AAEKLRK 2118
              E ++      A++Q   EA + RR +EE E   +  E + +A    QA     E L  
Sbjct: 2734 WGELQDNSQKKVAKLQKACEALRLRRSMEELENWLEPIEVELRAPTVGQALPGVGELLGT 2793

Query: 2119 EAEQEAARRAQAEQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETD- 2177
            + E EAA   +A QA     QA     E H   A+    Q  ++ Q   +LR  L+E   
Sbjct: 2794 QRELEAAVDKKARQAEALLGQAQAFVREGHC-LAQDVEEQARRLLQRFKSLREPLQERRT 2852

Query: 2178 --HQKNLL-------DEELQRLKAEATEAA---------------RQRSQVEEELFS--- 2210
                ++LL       DEE+  ++ +   AA                Q   +E E+ S   
Sbjct: 2853 ALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHEA 2912

Query: 2211 ------------------------VRVQMEELSKLKARIEAENRALILRDKDNTQRFLQE 2246
                                     RVQ  E +    R EA  R L+L+     Q+FL E
Sbjct: 2913 LTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQAQEAQQFLTE 2972

Query: 2247 EAEKMKQVAEEAARLS------VAAQEAARLRQLAE------------EDLAQQRALAEK 2288
              E    +AE    L        A    A LR+L              E L Q  AL E 
Sbjct: 2973 LLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIERLQQTAALLES 3032

Query: 2289 -------MLKEKMQAVQEA-----TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLA 2336
                    +  ++QAV+EA      R +A    LQ+Q +L Q +   L  D     +   
Sbjct: 3033 RKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLLDAWLTTKAAT 3092

Query: 2337 EETQGFQRTLEAER---------QRQLEMSAEAERLKLR-----------------VAEM 2370
             E+Q + + LE  +         +++++   +A+   LR                  A+ 
Sbjct: 3093 AESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAGTLERGAPRRYPHIQAQR 3152

Query: 2371 SRAQARAEEDAQRFRKQAEEI--GEKLHRTELAT-------QEKVTL------------V 2409
            SR +A  E   Q  + + E +    ++H  + A        QEK  L            V
Sbjct: 3153 SRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSV 3212

Query: 2410 QTLEIQRQQSDHDAERLREAIAELEREK--------------EKLQQEAKLLQLKSEE-- 2453
            +TL+ Q ++ + + E + + +A L+ E                K+Q+    LQ K++E  
Sbjct: 3213 RTLQQQHRRLERELEAMEKEVARLQTEACRLGQLHPAAPGGLAKVQEAWATLQAKAQERG 3272

Query: 2454 ---MQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLRE 2510
                Q  Q    L   Q L  ++  E+  L   E   E + A  EQL        Q++R 
Sbjct: 3273 QWLAQAAQGHAFLGRCQEL-LAWAQERQELASSEELAE-DVAGAEQLLGQHEELGQEIR- 3329

Query: 2511 EQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAEE-- 2568
            E + Q Q + QE Q+LV   + +     E  E ++  +  LQ+LE+    + +  AE   
Sbjct: 3330 ECRLQAQDLRQEGQQLV---DNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWG 3386

Query: 2569 NQRLREQLQLLE 2580
             Q+LR++L+  E
Sbjct: 3387 LQKLRQRLEQAE 3398



 Score =  139 bits (351), Expect = 5e-32
 Identities = 451/2066 (21%), Positives = 800/2066 (38%), Gaps = 334/2066 (16%)

Query: 873  AWQSLRRDVQLIRS-WSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLM 931
            A  ++R  +Q I++ W+    R+   + +RQ L SL+L  Q + +D  +   +  E  LM
Sbjct: 1246 AAHTVREQLQSIQAQWTRLQGRS--EQRRRQLLASLQL--QEWKQDVAELMQWMEEKGLM 1301

Query: 932  AEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQL---EACETRTVH-RLRL 987
            A  E      +  Q L+  E    E    +R +  L+ +  +L     C    +  RL+ 
Sbjct: 1302 AAHEPSGARRNILQTLKRHEAAESELLATRRHVEALQQVGRELLSRRPCGQEDIQTRLQG 1361

Query: 988  PLDKEPA--RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSEL 1045
               K  A  R+  +R  E Q+A  + E L + +     + E++    + S     LRS  
Sbjct: 1362 LRSKWEALNRKMTERGDELQQA-GQQEQLLRQLQDAKEQLEQLEGALQSSETGQDLRSSQ 1420

Query: 1046 ELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEA 1105
             L   + +Q+ S S     K+  ++ +  G   +  +L   ++ L+  + +   L     
Sbjct: 1421 RLQK-RHQQLESESRTLAAKMAALASMAHGMAASPAILEETQKHLRRLELLQGHL----- 1474

Query: 1106 TKASLKKLRAQAEAQQPTFDALRDE--------------------LRGAQEVGERLQQRH 1145
               +++ L+ QA  +   F  L +                     L GAQ     L ++H
Sbjct: 1475 ---AIRGLQLQASVELHQFCHLSNMELSWVAEHMPHGSPTSYTECLNGAQS----LHRKH 1527

Query: 1146 GERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDAR 1205
             E  VEV+  + +V ++L   +++ A    + + + +  ++L          G W +  R
Sbjct: 1528 KELQVEVKAHQGQVQRVLSSGRSLAASGHPQAQHIVEQCQELE---------GHWAELER 1578

Query: 1206 RRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAK------------QY 1253
              +        A +Q +++ +  +Q  L+  E  G  VEE +                + 
Sbjct: 1579 ACE--------ARAQCLQQAVTFQQYFLDVSELEGW-VEEKRPLVSSRDYGRDEAATLRL 1629

Query: 1254 INAIKDYELQLVTYKAQLEPVASPAKK---PKVQSGSESVIQEYVDLRTHYSELTTLTSQ 1310
            IN  +  + +L  Y + +E +   A+    P+V    + V+QE   LR     L  L + 
Sbjct: 1630 INKHQALQEELAIYWSSMEELDQTAQTLTGPEVPE-QQRVVQER--LREQLRALQELAAT 1686

Query: 1311 YIKFISETLRRME---EEERL-----AEQQRAEERERLAE-VEAALEKQRQLAEAHAQAK 1361
              + +  TLR  E   E E L     +++Q A+  E L E  E AL    + A+   Q +
Sbjct: 1687 RDRELEGTLRLHEFLREAEDLQGWLASQKQAAKGGESLGEDPEHALHLCTKFAKFQHQVE 1746

Query: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAA 1421
              ++R A    + + E ++ R  +A    +Q+   Q++LQ          QA+       
Sbjct: 1747 MGSQRVAA--CRLLAESLLERGHSAGPMVRQR---QQDLQTAWSELWELTQARGHALRDT 1801

Query: 1422 ERSRLRIEEEIRVVRLQLEA--------TERQRGGAEGELQALRARAEEAEAQKRQAQEE 1473
            E + LR+  ++  V  Q++           R   G E +L++ +    E    +RQ QE 
Sbjct: 1802 ETT-LRVHRDLLEVLTQVQEKATSLPNNVARDLCGLEAQLRSHQGLERELVGTERQLQEL 1860

Query: 1474 AERLRR-----------QVQDESQRKRQAEVELASRV---KAEAEAAREKQRALQALEEL 1519
             E   R            VQ   Q   QA   L  R+   +A+ E AR   R   A+ + 
Sbjct: 1861 LETAGRVQKLCPGPQAHAVQQRQQAVTQAWAVLQRRMEQRRAQLERARLLARFRTAVRDY 1920

Query: 1520 RLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSL----- 1574
               A    + L+  E  +         +A +   AEL+++   + + T   +++L     
Sbjct: 1921 ASWAARVRQDLQVEESSQEPSSGPLKLSAHQWLRAELEAREKLWQQATQLGQQALLAAGT 1980

Query: 1575 -----QEEHVAVAQLREEAER---RAQQQAEAERAREEAERELERWQ-LKANEALRLRLQ 1625
                 QEE  A+   R++  +   R Q++ +AE+  +   RE  R + + A + + L+  
Sbjct: 1981 PTKEVQEELRALQDQRDQVYQTWARKQERLQAEQQEQLFLRECGRLEEILAAQEVSLKTS 2040

Query: 1626 A-----EEVAQ-----QKSLAQAEAEKQKEEAEREA-----RRRGKAEEQAVRQRELAEQ 1670
            A     EEV Q     +  L    A+ +KE A RE      R R +     + QR +  +
Sbjct: 2041 ALGSSVEEVEQLIRKHEVFLKVLTAQDKKEAALRERLKTLRRPRVRDRLPILLQRRMRVK 2100

Query: 1671 ELEKQR------QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA-- 1722
            EL + R       L   +  Q     ++ I+  A+  +       L ++L  L +  A  
Sbjct: 2101 ELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPVPPGDLRDKLKPLLKHQAFE 2160

Query: 1723 AATQKRQELEAELAKVRAEMEVLLA-SKARAEEESRSTSEKSKQ---RLEAEAGRFRELA 1778
            A  Q  +E+   +AK   + E LLA S  RA E S+      K      +A A R +EL 
Sbjct: 2161 AEVQAHEEVMTSVAK---KGEALLAQSHPRAGEVSQRLQGLRKHWEDLRQAMALRGQELE 2217

Query: 1779 EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLA---------------AIGEA 1823
            +    L  L      +  + E++      +  + L   L                 +G+A
Sbjct: 2218 DRRNFLEFLQRVDLAEAWIQEKEVKMNVGDLGQDLEHCLQLRRRLREFRGNSAGDTVGDA 2277

Query: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRR------------------LEEQAAQH 1865
              +++ ++++L+ K  + E ++ + +  +    R                  LE      
Sbjct: 2278 C-IRSISDLSLQLKNRDPEEVKIICQRRSQLNNRWASFHGNLLRYQQQLEGALEIHVLSR 2336

Query: 1866 KADIEERLAQLRKASDSELERQKGL--VEDTLRQRRQVEEEILALKASFEKAAAGKAELE 1923
            + D   +  Q ++A    L+  K L  V+  LR+  ++E E+  ++A  E        LE
Sbjct: 2337 ELDNVTKRIQEKEALIQALDCGKDLESVQRLLRKHEELEREVHPIQAQVES-------LE 2389

Query: 1924 LELGRIRSNAEDT---LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEE--- 1977
             E+GR+   + +    LR ++Q   E+  Q +  A++ R   +A  + QK  A  +E   
Sbjct: 2390 REVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDALHQAQKLQAMLQELLV 2449

Query: 1978 AARQRKAALEEVERLKAKVEEARRLRE----RAEQES-ARQLQLAQEAAQKRLQAEEKAH 2032
            +A++ +A ++     ++ VE  R L E    +AE +S    + LA+   Q+ L A    H
Sbjct: 2450 SAQRLRAQMDTSPAPRSPVEARRMLEEHQECKAELDSWTDSISLARSTGQQLLTA---GH 2506

Query: 2033 AF--------------------AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
             F                    A Q+ + +LQQ L+ +  +    + E     +    A 
Sbjct: 2507 PFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALELQLFLSSVEKMERWLCSKEDSLAS 2566

Query: 2073 EA------------------RVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAE 2114
            E                       E +A +       A  L Q    +AQ+ A  +  A 
Sbjct: 2567 EGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGHPEAQS-ALGRCQAM 2625

Query: 2115 KLRKEA--EQEAARRAQAE-----QAALRQKQAADAEM-EKHKKFAEQTLRQKAQVEQEL 2166
             LRKEA   Q   RR + E     QA L+  Q   A + EK+    E+ L   A +  +L
Sbjct: 2626 LLRKEALFRQAGTRRHRLEELRQLQAFLQDSQEVAAWLREKNLVALEEGLLDTAMLPAQL 2685

Query: 2167 T---TLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLK- 2222
                  + +L+ + HQ+  L  E QRL      A+    +  EEL ++  ++++ S+ K 
Sbjct: 2686 QKQQNFQAELDASMHQQQELQREGQRLLQGGHPASEAIQERLEELGALWGELQDNSQKKV 2745

Query: 2223 ARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQ 2282
            A+++    AL LR          EE E   +  E   R     Q    + +L    L  Q
Sbjct: 2746 AKLQKACEALRLRRS-------MEELENWLEPIEVELRAPTVGQALPGVGEL----LGTQ 2794

Query: 2283 RALAEKMLKEKMQA---VQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEET 2339
            R L   + K+  QA   + +A     E   L Q  E   EQARRL +  + + + L E  
Sbjct: 2795 RELEAAVDKKARQAEALLGQAQAFVREGHCLAQDVE---EQARRLLQRFKSLREPLQERR 2851

Query: 2340 QGFQRT---LEAERQRQLEMSAEAERLKLRVAE---MSRAQARAEEDAQRFRKQAEEIGE 2393
               +     L+  R    EM+   E+L L  A+    S +  R  ++  +  +      E
Sbjct: 2852 TALEARSLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQEQHQNLESEMSSHE 2911

Query: 2394 KLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEE 2453
             L R  L T  K+          Q     A  +   + +LE+    L+ EA   +L  ++
Sbjct: 2912 ALTRVVLGTGYKLV---------QAGHFAAHEVAARVQQLEKAMAHLRAEAARRRLLLQQ 2962

Query: 2454 MQTVQQ--EQLLQETQALQQS--FLSEKD---------SLLQR----ERFIEQEKAKLEQ 2496
             Q  QQ   +LL+    L +    L  +D         +LL+R    +R +E    ++E+
Sbjct: 2963 AQEAQQFLTELLEAGSWLAERGHVLDSEDMGHSAEATQALLRRLEATKRDLEAFSPRIER 3022

Query: 2497 LFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQ 2556
            L Q       +   E  +   Q++  R+     +  A  R H  +E ++  Q E + L  
Sbjct: 3023 LQQTAALLESRKNPESPKVLAQLQAVREAHAELLRRAEARGHGLQEQLQLHQLERETLLL 3082

Query: 2557 QRRQQEELLAEENQRLREQLQ---LLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDG 2613
                  +    E+Q   + L+   +LEE+  A     + +  ++V A + L      L+ 
Sbjct: 3083 DAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQSLGQAKVYALRKLAG---TLER 3139

Query: 2614 PAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRHYLQGR 2673
             A    P       R + + +RL +A     E L    + H+     A        LQGR
Sbjct: 3140 GAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHEVHSFQQAAAE-------LQGR 3192

Query: 2674 SSIAGLLLKATN--EKLSVYAALQRQ 2697
                  L+K  +    LS    LQ+Q
Sbjct: 3193 MQEKTALMKGEDGGHSLSSVRTLQQQ 3218



 Score = 67.0 bits (162), Expect = 4e-10
 Identities = 256/1209 (21%), Positives = 446/1209 (36%), Gaps = 193/1209 (15%)

Query: 322  QSLEGAVQAGQLKVPPGYHPL-----DVEKEWGKLHVAILEREKQLRSEFERLECLQRIV 376
            +SLE  V     + P   H L     +V + W +L     +R + L +   + + LQ ++
Sbjct: 2386 ESLEREVGRLCQRSPEAAHGLRHRQQEVAESWWQLRSRAQKRREALDA-LHQAQKLQAML 2444

Query: 377  TKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQT 436
             +L + A     Q++ + A        + A ++ +   E + +LD     I L  +  Q 
Sbjct: 2445 QELLVSAQRLRAQMDTSPAPRSP----VEARRMLEEHQECKAELDSWTDSISLARSTGQQ 2500

Query: 437  LKDGRHPQGEQMYRRVYRLHERLVAIR---TEYNLRLKAGVAAPATQVAQVTLQSVQRRP 493
            L    HP    + + +  L + L ++     E+ L+L+  +        Q+ L SV++  
Sbjct: 2501 LLTAGHPFSSDIRQVLAGLEQELSSLEGAWQEHQLQLQQALEL------QLFLSSVEKME 2554

Query: 494  EL----EDSTLRY-LQDLLAWVEENQHRVDGAEWGVDLPS--VEAQLGSHRGLHQSIEEF 546
                  EDS     L D LA +E    +    EW +++ +  + A   + RGLHQ     
Sbjct: 2555 RWLCSKEDSLASEGLWDPLAPMEPLLWKHKMLEWDLEVQAGKISALEATARGLHQGGH-- 2612

Query: 547  RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYA--KLLNSSKARLRSLESLHSFVAAAT 604
                           P  + A   C   L  + A  +   + + RL  L  L +F+  + 
Sbjct: 2613 ---------------PEAQSALGRCQAMLLRKEALFRQAGTRRHRLEELRQLQAFLQDSQ 2657

Query: 605  KELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLRED 664
            +   WL EK    +     D    + A+ +       EL+    + +ELQ  G RLL+  
Sbjct: 2658 EVAAWLREKNLVALEEGLLD-TAMLPAQLQKQQNFQAELDASMHQQQELQREGQRLLQGG 2716

Query: 665  HPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALR 724
            HPA   ++     L   W             L++N+         ++   +LQK  EALR
Sbjct: 2717 HPASEAIQERLEELGALW-----------GELQDNS---------QKKVAKLQKACEALR 2756

Query: 725  RKYSCDRSATVTRLEDLLQDAQDEKE-----QLNEYKGHLSGLAKRAKAVVQLKPRHPAH 779
             + S +       LE+ L+  + E       Q     G L G  +  +A V  K R  A 
Sbjct: 2757 LRRSME------ELENWLEPIEVELRAPTVGQALPGVGELLGTQRELEAAVDKKARQ-AE 2809

Query: 780  PMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPP 839
             + G           Q +  V +G  C L    +    ++L    S              
Sbjct: 2810 ALLG-----------QAQAFVREG-HC-LAQDVEEQARRLLQRFKS-------------L 2843

Query: 840  NQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEE 899
             +  QE  T LEA+     +L  +   D    +AW   +  +   + +  +       +E
Sbjct: 2844 REPLQERRTALEAR-----SLLLKFFRDADEEMAWVQEKLPLAAAQDYGQSLSAVRHLQE 2898

Query: 900  QRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESR 959
            Q Q L S    ++A  R     G    +    A  E  +     ++ +  L   A     
Sbjct: 2899 QHQNLESEMSSHEALTRVVLGTGYKLVQAGHFAAHEVAARVQQLEKAMAHLRAEAARRRL 2958

Query: 960  CQRCISELKDIRLQLEACETRTVHRLRLPLDKEP---ARECAQRIAEQQKA-QAEVEGLG 1015
              +   E +    +L    +    R  + LD E    + E  Q +  + +A + ++E   
Sbjct: 2959 LLQQAQEAQQFLTELLEAGSWLAERGHV-LDSEDMGHSAEATQALLRRLEATKRDLEAFS 3017

Query: 1016 KGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRG 1075
              + RL   A   L     +P +P +       L +L+ VR   A  L + +      RG
Sbjct: 3018 PRIERLQQTA--ALLESRKNPESPKV-------LAQLQAVREAHAELLRRAEA-----RG 3063

Query: 1076 TQGAEEVLRAHEEQLKEAQAVPATLPELEATKAS--LKKLRAQAEAQQPTFDALRDELR- 1132
              G +E L+ H+ + +E   + A L    AT  S    +     +  +  FDA R E++ 
Sbjct: 3064 -HGLQEQLQLHQLE-RETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFRKEVQS 3121

Query: 1133 -------GAQEVGERLQQRHGERDVEVERWRERVAQLLERW-QAVLAQTDVRQRELEQLG 1184
                     +++   L++    R   ++  R R+    ER  QA+ A+T     E     
Sbjct: 3122 LGQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKART-----ENLAAA 3176

Query: 1185 RQLRYYRESADPLGAWLQDARRRQEQIQAMPLADS----QAVREQLRQEQALLEEIERHG 1240
             ++  ++++A  L        R QE+   M   D      +VR   +Q + L  E+E   
Sbjct: 3177 HEVHSFQQAAAELQG------RMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAME 3230

Query: 1241 EKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTH 1300
            ++V   Q  A +                 QL P A+P    KVQ  + + +Q     R  
Sbjct: 3231 KEVARLQTEACRL---------------GQLHP-AAPGGLAKVQE-AWATLQAKAQERGQ 3273

Query: 1301 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1360
            +         ++    E L   +E + LA  +  E  E +A  E  L +  +L +   + 
Sbjct: 3274 WLAQAAQGHAFLGRCQELLAWAQERQELASSE--ELAEDVAGAEQLLGQHEELGQEIREC 3331

Query: 1361 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQ--EELQQLRQSSEAE------IQ 1412
            + QA+   +E QQ +        E     Q+ +  +Q  EE   LR    AE      ++
Sbjct: 3332 RLQAQDLRQEGQQLVDNSHFMSAEVTECLQELEGRLQELEEAWALRWQRCAESWGLQKLR 3391

Query: 1413 AKARQAEA----AERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKR 1468
             +  QAEA     E   L+ +    V  ++L     Q      +L+ L A  EE  AQ +
Sbjct: 3392 QRLEQAEAWLACWEGLLLKPDYGHSVSDVELLLHRHQ------DLEKLLAAQEEKFAQMQ 3445

Query: 1469 QAQEEAERL 1477
            + + E E L
Sbjct: 3446 KTEMEQELL 3454



 Score = 53.5 bits (127), Expect = 5e-06
 Identities = 70/312 (22%), Positives = 116/312 (37%), Gaps = 42/312 (13%)

Query: 256  QLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKN 315
            QL+  +     LLL  W+    A  E + +    E +++L  +F  F+      KE    
Sbjct: 3069 QLQLHQLERETLLLDAWLTTKAATAESQDYGQDLEGVKVLEEKFDAFR------KEVQSL 3122

Query: 316  RSKGIY--QSLEGAVQAGQLKVPPGYHPLD--VEKEWGKLHVAILEREKQLRSEFERLEC 371
                +Y  + L G ++ G  +  P        +E  W +L  AI  R + L +  E    
Sbjct: 3123 GQAKVYALRKLAGTLERGAPRRYPHIQAQRSRIEAAWERLDQAIKARTENLAAAHE---- 3178

Query: 372  LQRIVTKLQMEAGLCEEQLNQADALLQSDV---RLLAAGKVPQRAGEVERDLDKADSMIR 428
                V   Q  A   + ++ +  AL++ +     L +   + Q+   +ER+L+  +  + 
Sbjct: 3179 ----VHSFQQAAAELQGRMQEKTALMKGEDGGHSLSSVRTLQQQHRRLERELEAMEKEVA 3234

Query: 429  LLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQS 488
             L  +   L    HP       +V                   A + A A +  Q   Q+
Sbjct: 3235 RLQTEACRLGQ-LHPAAPGGLAKVQEAW---------------ATLQAKAQERGQWLAQA 3278

Query: 489  VQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRA 548
             Q       + L   Q+LLAW +E Q      E   D+   E  LG H  L Q I E R 
Sbjct: 3279 AQGH-----AFLGRCQELLAWAQERQELASSEELAEDVAGAEQLLGQHEELGQEIRECRL 3333

Query: 549  KIERARSDEGQL 560
            + +  R +  QL
Sbjct: 3334 QAQDLRQEGQQL 3345


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score =  352 bits (902), Expect = 6e-96
 Identities = 484/1900 (25%), Positives = 851/1900 (44%), Gaps = 251/1900 (13%)

Query: 916  RDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLE 975
            R  +D   F P DR + E E G          Q   Q  QE+ R      EL +   Q E
Sbjct: 114  RQEEDQRRFEPRDRQL-EEEPG----------QRRRQKRQEQER------ELAEGEEQSE 156

Query: 976  ACETRTVHRLRLPLDKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPS 1035
              E R   R R   D+E  R+  Q   E+++ +AE E L       S +  +    P+  
Sbjct: 157  KQE-RLEQRDRQRRDEELWRQ-RQEWQEREERRAEEEQL------QSCKGHETEEFPDEE 208

Query: 1036 PAAPTLRSELELTLGKLEQVRS-----LSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQL 1090
                  R  LEL     E+ +         ++ E+ +      +  +  E VLR  EE+L
Sbjct: 209  QL--RRRELLELRRKGREEKQQQRRERQDRVFQEEEE------KEWRKRETVLRKEEEKL 260

Query: 1091 KEAQAVPATLPELEATKASLKKL-RAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERD 1149
            +E +  P    EL+  +  L+KL R +   ++   +  +  LR  Q++  + ++   E+ 
Sbjct: 261  QEEE--PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQ 318

Query: 1150 VEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQE 1209
             E    +ER  Q  ER +  L +    +RE +QL R+    R     L    ++ RR Q+
Sbjct: 319  EERREQQERREQQEERREQQLRREQEERRE-QQLRREQEEERRE-QQLRREQEEERREQQ 376

Query: 1210 QIQAMPLADSQAVR--EQLRQEQALLEE--IERHGEKVEECQRFAKQYINAIKDYELQLV 1265
              +   L   Q +R  +QLR+EQ L  E  + R  +   E Q   +Q +   ++ E    
Sbjct: 377  LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEE---- 432

Query: 1266 TYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRR---- 1321
             ++ + E      +  + Q      ++   +   H  E      Q +K   E  RR    
Sbjct: 433  RHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE---RRKQQLKRDQEEERRERWL 489

Query: 1322 -MEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAEREAKELQQRMQEEV 1379
             +EEEER  +Q+R E++ R  + E   ++ +RQ  E   Q + ++E++ +  Q+  +E++
Sbjct: 490  KLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL 549

Query: 1380 VRREEAAVDAQQQKRSIQEELQQ-LRQSSEAEIQAKARQAEAAERSRLRIEEEIRV-VRL 1437
            ++REE       +KR  QE  +Q L++  E       ++ E   + RL+ E+E R+  RL
Sbjct: 550  LKREE-------EKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL 602

Query: 1438 QLEATERQRGGAEGELQALRARAEEAEAQKRQ----AQEEAERLRRQVQDESQRKRQAEV 1493
            + E  ER     + E +  R + EE E ++RQ    ++E+ ER ++Q++ E Q +R+   
Sbjct: 603  KREEVERLE---QEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE--- 656

Query: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQ-VQVALETAQRSA 1552
                R+K E E  R +QR  +  EE     E  E+ L + E E+AR+ ++  +   Q   
Sbjct: 657  ---QRLKREEEEERLEQRLKREHEE-----ERREQELAEEEQEQARERIKSRIPKWQWQL 708

Query: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELE-R 1611
            E+E  ++++    +  + E   + +     + R E+E + Q++  A R ++E E+  +  
Sbjct: 709  ESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFT 768

Query: 1612 WQLKANEAL---RLRLQAEEVAQQKSLAQAEAEKQK--------EEAEREARRRGK---- 1656
            WQ +A E     R RL A    +++   Q  AE+++        EE E+E RRR +    
Sbjct: 769  WQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRRERE 828

Query: 1657 ------AEEQAVRQRELAEQELEKQRQLAEGTAQQ-----------RLAAEQELIRLR-- 1697
                   EE+ +++RE A+Q  E++  L E   ++           R   E+E  R R  
Sbjct: 829  KELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHT 888

Query: 1698 -----AETEQGEQQRQLLEEELARLQREAAAATQKRQELE---AELAKVRAEMEVLL--- 1746
                 A  EQ  +++QLL+EE   LQRE     ++RQE E    E  +++ E E LL   
Sbjct: 889  LYAKPALQEQLRKEQQLLQEEEEELQRE-EREKRRRQEQERQYREEEQLQQEEEQLLREE 947

Query: 1747 ASKARAEEESRS--TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQ----LAEE 1800
              K R +E  R     +K +Q+ E   G   E      R +   EE + Q++    L EE
Sbjct: 948  REKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREE 1007

Query: 1801 DAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRL-- 1858
               R+R E ER   +K     E  +L  E     +EK    ER R+  E+E  Q+     
Sbjct: 1008 REKRRRQEWERQYRKKDELQQEEEQLLREE----REKRRLQERERQYREEEELQQEEEQL 1063

Query: 1859 --EEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAA 1916
              EE+  + + ++E    Q RK  + + E ++ L E+  ++RRQ  E     +   E+  
Sbjct: 1064 LGEERETRRRQELER---QYRKEEELQQEEEQLLREEPEKRRRQERERQCREE---EELQ 1117

Query: 1917 AGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEE 1976
              + +L  E    R   E   + +E+ E++   ++ L  E E+RRR+  ER  +    EE
Sbjct: 1118 QEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYR----EE 1173

Query: 1977 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK---RLQAE-EKAH 2032
            E  +Q +  L   E+ K + E  R+ RE  E +  ++ Q  ++  Q+   + Q E EK +
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKEN 1233

Query: 2033 AF---AVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
            A     V  K +E +Q  Q E S L   + + +      E+ E  R Q  R   Q  R  
Sbjct: 1234 AVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHF 1293

Query: 2090 EEAERLKQSAEEQAQAR-AQAQAAAEKLRKEAE-----QEAARRAQAEQAALRQKQAAD- 2142
             E E+L++  +++A+ R  ++Q   + LR+E E     QE  R+ + E+  L++++    
Sbjct: 1294 PEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPL 1353

Query: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
               E+ +KF E+ LR + Q  + L     +L   + ++  L EE Q+L+ +  E  +Q  
Sbjct: 1354 RRQERDRKFREEELRHQEQGRKFLEE-EQRLRRQERERKFLKEE-QQLRCQ--EREQQLR 1409

Query: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEE----AEKMKQVAEEA 2258
            Q  +  F  R + ++LS+ +   +       +R ++  ++FL+EE     E+ ++  EE 
Sbjct: 1410 QDRDRKF--REEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEE 1467

Query: 2259 ARLSVAAQE----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR--LKAEAELLQQ 2312
              L    ++      R R+  EE+   +R   ++  +E+    QE  R  L+ E +L +Q
Sbjct: 1468 QLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQ 1527

Query: 2313 QKE---LAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2369
            Q++   L +EQ  R QE  +Q  Q    + +  ++  +   ++QL       + +L   +
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587

Query: 2370 MSRAQARAE--EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLR 2427
            + R +   +  ED Q+ R+Q  +   +  R     +++    Q L+ + +Q  H  ER R
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDE----QLLQEREEQQLHRQERDR 1643

Query: 2428 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQ-------QSFLSEKDSL 2480
            +    LE E +  +QE +       + +  ++EQLLQE +  Q       + F  E+  L
Sbjct: 1644 KF---LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700

Query: 2481 LQRER---FIEQE----KAKLEQLFQDEVAKAQQLREEQQRQQQQ----MEQERQRLVAS 2529
             ++ER   F+++E    + +LE+ F++E    Q+  +EQ R+Q++    +E+E+ R    
Sbjct: 1701 RRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPERE 1760

Query: 2530 MEEARRRQHE---AEEGVRRKQEELQQLEQQR-----RQQEELLAE-ENQRLR------- 2573
             ++ RR++ +    EE   R++ E QQL  Q      R++E+L  E E Q+LR       
Sbjct: 1761 EQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGK 1820

Query: 2574 -----EQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLR 2628
                 EQLQL E++ R       +  A +  AT+              E E     +  R
Sbjct: 1821 YRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE--------KSRREEQELWQEEEQKR 1872

Query: 2629 RKVSAQRLQEAGILSAEELQRLAQGHTTVDELARREDVRH 2668
            R+   ++L+E  I      Q+  Q H  V E+  +E   H
Sbjct: 1873 RQERERKLREEHI---RRQQKEEQRHRQVGEIKSQEGKGH 1909



 Score =  346 bits (888), Expect = 3e-94
 Identities = 429/1702 (25%), Positives = 734/1702 (43%), Gaps = 233/1702 (13%)

Query: 1107 KASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERW 1166
            K SL + R Q E Q+  F+    +L   +E G+R +Q+  E++ E+    E+  +     
Sbjct: 106  KESLLQDRRQEEDQR-RFEPRDRQLE--EEPGQRRRQKRQEQERELAEGEEQSEK----- 157

Query: 1167 QAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAV--RE 1224
            Q  L Q D RQR  E+L RQ + ++E         ++ R  +EQ+Q+    +++     E
Sbjct: 158  QERLEQRD-RQRRDEELWRQRQEWQER--------EERRAEEEQLQSCKGHETEEFPDEE 208

Query: 1225 QLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQ 1284
            QLR+ + L  E+ R G + ++ QR  +Q                                
Sbjct: 209  QLRRRELL--ELRRKGREEKQQQRRERQ-------------------------------- 234

Query: 1285 SGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVE 1344
               + V QE  +      E T L  +  K   E  +R  E +   EQ R  ER+ L    
Sbjct: 235  ---DRVFQEEEEKEWRKRE-TVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290

Query: 1345 AALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEEL--QQ 1402
               E+Q+Q      Q + + E E +E Q+  +E+  RRE+     +QQ R  QEE   QQ
Sbjct: 291  QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQ 350

Query: 1403 LRQSSE---AEIQAKARQAEAAERSRLRIEEEI-------RVVRLQLEATERQRGGAEGE 1452
            LR+  E    E Q +  Q E     +LR E+++       R  +L+ E   R+      E
Sbjct: 351  LRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE 410

Query: 1453 LQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQRKRQAEVELASRVKAEAEAAR-EKQ 1510
             Q  R +    E Q R+ QEE    ++  Q+   QR ++ + E    +K E E  R E++
Sbjct: 411  QQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQE 470

Query: 1511 RALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQL 1570
            R  Q L+  R Q EE   R  + E E  R+ Q   E   R  + E + +R    E+  +L
Sbjct: 471  RRKQQLK--RDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERL 528

Query: 1571 ERSLQEEHVAVAQL-REEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1629
            ++ L+ E     QL RE+ ERR Q     E  R E ER  +R + +  E     L+ EE 
Sbjct: 529  QQRLRSEQ----QLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEE 584

Query: 1630 AQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1689
             +Q+ L + + E+ ++  +RE   R + EE+  ++ +  E E E+++QL +   Q+    
Sbjct: 585  RRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQ 644

Query: 1690 EQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASK 1749
            +Q    LR E ++  +QR   EEE  RL+          Q L+ E  + R E E+    +
Sbjct: 645  QQ----LRREQQERREQRLKREEEEERLE----------QRLKREHEEERREQELAEEEQ 690

Query: 1750 ARAEEESRSTSEKSKQRLEAEAGR------FRELAEEAARLRALAEEAKRQRQ-----LA 1798
             +A E  +S   K + +LE+EA         R   +E  R R   EE +R+R+       
Sbjct: 691  EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750

Query: 1799 EEDAARQRAEAE-------RVLAEKLAAIGE-----ATRLKTEAEIALKEKEAENERLRR 1846
            EE A RQ+ E E       +  AE+ +  G         L+ + E  L+ +E +    R 
Sbjct: 751  EERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRF 810

Query: 1847 LAEDEAFQRRRLEEQAAQHKADI--EERLAQLRKASDSELERQKGLVEDTLRQRR----- 1899
            L E+E  ++RR + +  + +     EE   Q R+ +    E + GL ED  R+R      
Sbjct: 811  LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870

Query: 1900 ------QVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQL 1953
                  Q+EEE    + +     A + +L  E   ++   E+  R + +      ++RQ 
Sbjct: 871  DQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQY 930

Query: 1954 AAEEERRRRE----AEERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQE 2009
              EE+ ++ E     EER ++     E   R+ K   ++ E+L  +  E RR +ER E++
Sbjct: 931  REEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQER-EKK 989

Query: 2010 SARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAE 2069
               + +L QE  Q   +  EK      +++ ++  +  Q+E+ +L + R +     R  +
Sbjct: 990  YREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQ 1049

Query: 2070 EAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQ 2129
              EE  +Q E E        E   R +Q  E Q +   + Q   E+L +E E E  RR +
Sbjct: 1050 YREEEELQQEEEQLLGE---ERETRRRQELERQYRKEEELQQEEEQLLRE-EPEKRRRQE 1105

Query: 2130 AEQAALRQKQAADAE----MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDE 2185
             E+    +++    E     E+ +K   Q L ++ + E+E+     QL   + +K    +
Sbjct: 1106 RERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKR-RRQ 1164

Query: 2186 ELQRLKAEATEAARQRSQ-VEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFL 2244
            EL+R   E  E  ++  Q + EE    R + E   + +  ++ + R    RD+D  +  L
Sbjct: 1165 ELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQ-RSDL 1223

Query: 2245 QEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQ-------QRALAEKMLKEKMQ-- 2295
            + + E  K+ A    ++    +E  + RQL +  L         Q  L E+  +++ Q  
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQER 1283

Query: 2296 -AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAER--QR 2352
               Q+  R   E E L++++   Q++A+R     ++  Q L EE +  +R  E +R  + 
Sbjct: 1284 RRWQQRDRHFPEEEQLEREE---QKEAKRRDRKSQEEKQLLREEREEKRRRQETDRKFRE 1340

Query: 2353 QLEMSAEAERLKLRVAEMSRAQARAE-----------EDAQRFRKQAEEIGEKLHRTELA 2401
            + ++  E E   LR  E  R     E           E+ QR R+Q  E        +L 
Sbjct: 1341 EEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLR 1400

Query: 2402 TQEKVTLV----------QTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKS 2451
             QE+   +          +  ++ RQ+ D       + +   ERE++ L++E +L Q + 
Sbjct: 1401 CQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERH 1460

Query: 2452 EEMQTVQQEQLLQETQALQ-------QSFLSEKDSLLQRER-----------------FI 2487
             + +  ++EQLLQE +  Q       + FL E+  L ++ER                 F+
Sbjct: 1461 RKFR--EEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFL 1518

Query: 2488 EQE-----KAKLEQLFQDEVAKAQQLREEQQRQ--------QQQMEQERQRLVASMEEAR 2534
            E+E     + +  +  Q+E    +Q R +Q+RQ        ++Q+ QER+    S +E  
Sbjct: 1519 EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERD 1578

Query: 2535 RRQHEAEEGVRRKQEE---LQQLEQQRRQ--QEELLAEENQRLREQLQLLEEQHRAALAH 2589
            R+    E+ VRR+++E   ++  +Q RRQ  Q++L  E +++ RE  QLL+E+    L  
Sbjct: 1579 RKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638

Query: 2590 SEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQR 2649
             E          +        L     E +  H  D   R+   Q LQE         +R
Sbjct: 1639 QER--------DRKFLEEEPQLRRQEREQQLRHDRDRKFRE-EEQLLQEGEEQQLRRQER 1689

Query: 2650 LAQGHTTVDELARREDVRHYLQ 2671
              +      +L R+E  R +LQ
Sbjct: 1690 DRKFREEEQQLRRQERERKFLQ 1711



 Score =  324 bits (831), Expect = 1e-87
 Identities = 430/1733 (24%), Positives = 766/1733 (44%), Gaps = 267/1733 (15%)

Query: 875  QSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDAGGFGPEDRLMAER 934
            Q LRR+ QL R   L   + L+ E+Q +    L    Q  LR  Q              R
Sbjct: 375  QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQ--LRREQ-----------QLRR 421

Query: 935  EYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPA 994
            E            Q L +  +EE   Q+   E ++ RL+ E  E R      L  ++E  
Sbjct: 422  E------------QQLRREQEEERHEQKHEQERREQRLKREQEERRD----WLKREEETE 465

Query: 995  RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQ 1054
            R   +R  +Q K   E E             E+ L L E        R E +L   + E+
Sbjct: 466  RHEQERRKQQLKRDQEEE-----------RRERWLKLEEEERREQQERREQQLR-REQEE 513

Query: 1055 VRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLR 1114
             R       E+ + +   +R    +E+ LR  +E+ +E          LE  +   +  R
Sbjct: 514  RREQRLKRQEEEERLQQRLR----SEQQLRREQEERREQLLKREEEKRLEQERREQRLKR 569

Query: 1115 AQAEAQQPTF--DALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLL-------ER 1165
             Q E +      +  R + R  +E  ERL+QR    +VE     ER  Q L       ER
Sbjct: 570  EQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEER 629

Query: 1166 WQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQ 1225
             Q +L   +  +R  +QL R+ +  RE         Q  +R +E+         + + ++
Sbjct: 630  RQQLLKSEEQEERRQQQLRREQQERRE---------QRLKREEEE---------ERLEQR 671

Query: 1226 LRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAK-----K 1280
            L++E    EE  R  E  EE Q  A++ I +      ++  ++ QLE  A   +     +
Sbjct: 672  LKREH---EEERREQELAEEEQEQARERIKS------RIPKWQWQLESEADARQSKVYSR 722

Query: 1281 PKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER- 1339
            P+ Q G     ++    R   SEL                + +EEER   QQ+ EE+ R 
Sbjct: 723  PRKQEGQRRRQEQEEKRRRRESEL----------------QWQEEERAHRQQQEEEQRRD 766

Query: 1340 ---LAEVEAALEKQRQLAEAHAQAKAQAERE--AKELQQRMQEEVVRREEAAVDAQQQKR 1394
                 + E   E+ RQ   A    + Q ER+  A+E QQR ++  +  EE     ++Q+R
Sbjct: 767  FTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQR-EQRFLPEEEEKEQRRRQRR 825

Query: 1395 SIQEELQQLRQSSEAEIQAKARQ--------AEAAERSRLRIEEEIRVVRLQLEATERQR 1446
              ++ELQ L +  + + + +A+Q         E  ER R + +   +  R QLE   ++R
Sbjct: 826  EREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRR 885

Query: 1447 GGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAA 1506
                  L A  A  E+   +++  QEE E L+R+ +++ +R+ Q                
Sbjct: 886  ---RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQ------------ERQY 930

Query: 1507 REKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEAELQSKRASFAEK 1566
            RE+++  Q  EE +L  EE E+R RQ    + R+ +   +  ++    E + +R    EK
Sbjct: 931  REEEQLQQ--EEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988

Query: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAE-RAREEAERELERWQLKANEALRLRLQ 1625
              + E  LQ+E   +  LREE E+R +Q+ E + R ++E ++E E+   +  E  RL+ +
Sbjct: 989  KYREEEELQQEEEQL--LREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER 1046

Query: 1626 AEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQ 1685
              +  +++ L Q E +   E  ERE RRR + E Q  ++ EL ++E     QL     ++
Sbjct: 1047 ERQYREEEELQQEEEQLLGE--ERETRRRQELERQYRKEEELQQEE----EQLLREEPEK 1100

Query: 1686 RLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELE---AELAKVRAEM 1742
            R   E+E  + R E E  +++ QLL EE  +         ++RQELE    E  +V+ E 
Sbjct: 1101 RRRQERER-QCREEEELQQEEEQLLREEREK---------RRRQELERQYREEEEVQQEE 1150

Query: 1743 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ---RQLAE 1799
            E LL    R E E R   E  +Q  E E     EL +E  +L    +E +RQ   RQ  E
Sbjct: 1151 EQLL----REEPEKRRRQELERQYREEE-----ELQQEEEQLLREEQEKRRQERERQYRE 1201

Query: 1800 EDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKE-----KEAENERLRRLAEDEAFQ 1854
            E+  +++   +R   E   +     + + E E A+++     K  ENE+ R+L + +   
Sbjct: 1202 EEELQRQKRKQRYRDEDQRS-DLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL-- 1258

Query: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDT-LRQRRQVE-EEILALKASF 1912
            R R  +Q  QH       L   ++  D E ER++    D    +  Q+E EE    K   
Sbjct: 1259 RDRQSQQDLQH-------LLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311

Query: 1913 EKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERV---- 1968
             K+   K  L  E    R   E   + +E+ +L   R+ Q    +ER R+  EE +    
Sbjct: 1312 RKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQE 1371

Query: 1969 --QKSLAAEEEAARQRKAA--LEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR 2024
              +K L  E+   RQ +    L+E ++L+ +  E +  ++R  +    + QL+++   ++
Sbjct: 1372 QGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRK 1431

Query: 2025 LQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR----GEAEAARRAAEEAEEARVQAER 2080
             + EE+      Q + QE ++   +E+  L Q R     E E   +  EE +  R + +R
Sbjct: 1432 FREEEQ------QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDR 1485

Query: 2081 EAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARR-AQAEQAALRQKQ 2139
            +  +  +Q+   ER ++  E++ +++   +   E+ ++   Q+  R+  Q EQ   RQ++
Sbjct: 1486 KFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQER 1545

Query: 2140 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAE----AT 2195
                  ++ +KF     R++ Q+ QE    +L  +E D +  L +++++R + E      
Sbjct: 1546 GQQRRQDRDRKF-----REEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMED 1600

Query: 2196 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
            E   +R + +++L   R + +   +   ++  E     L  ++  ++FL+EE +  +Q  
Sbjct: 1601 EQQLRRQEGQQQL---RQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQER 1657

Query: 2256 EEAAR--LSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2313
            E+  R       +E  +L Q  EE   +++    K  +E+    Q+  R + E + LQ++
Sbjct: 1658 EQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEE----QQLRRQERERKFLQEE 1713

Query: 2314 KELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRA 2373
            ++L +++  R   ++EQ+ Q+  +E        +  RQ +     E E+L+    E    
Sbjct: 1714 QQLRRQELERKFREEEQLRQETEQE--------QLRRQERYRKILEEEQLR---PEREEQ 1762

Query: 2374 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAEL 2433
            Q R +E  ++FR++ E++ ++    +L +QE             +   + E+LR+     
Sbjct: 1763 QLRRQERDRKFREE-EQLRQEREEQQLRSQES-----------DRKFREEEQLRQ----- 1805

Query: 2434 EREKEKL--QQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQEK 2491
            ERE+++L  QQ     + + E++Q  +QEQ L++ +  Q             E+F  QEK
Sbjct: 1806 EREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYR---------AEEQFATQEK 1856

Query: 2492 AKLE--QLFQDEVAKAQQLREEQQRQQ----QQMEQERQRLVASMEEARRRQH 2538
            ++ E  +L+Q+E  K +Q RE + R++    QQ E++R R V  ++    + H
Sbjct: 1857 SRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGH 1909



 Score =  321 bits (822), Expect = 1e-86
 Identities = 344/1299 (26%), Positives = 606/1299 (46%), Gaps = 105/1299 (8%)

Query: 1359 QAKAQAEREAKELQQRMQEEVVRR---EEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKA 1415
            + +A+ + +   LQ R QEE  RR    +  ++ +  +R  Q+  +Q R+ +E E Q++ 
Sbjct: 98   EKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSE- 156

Query: 1416 RQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRA-RAEEAEAQKRQAQEEA 1474
            +Q    +R R R +EE+   R + +  E +R   E +LQ+ +    EE   +++  + E 
Sbjct: 157  KQERLEQRDRQRRDEELWRQRQEWQEREERR-AEEEQLQSCKGHETEEFPDEEQLRRREL 215

Query: 1475 ERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAE 1534
              LRR+ ++E Q++R+   E   RV  E E    ++R     +E        E +L++ E
Sbjct: 216  LELRRKGREEKQQQRR---ERQDRVFQEEEEKEWRKRETVLRKE--------EEKLQEEE 264

Query: 1535 VERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQ 1594
             +R R++Q   E  ++    EL+ +R    ++  +L R  Q       + RE+ E R +Q
Sbjct: 265  PQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQ 324

Query: 1595 QAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRR 1654
            Q   E+  E  E++L R Q +  E    R Q EE  +Q+   + E E+++++  RE + R
Sbjct: 325  QERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384

Query: 1655 GKAEEQAVRQREL-AEQELEKQRQLAEGTAQQRLAAEQELIR-LRAETEQGEQQRQLLEE 1712
               E+Q  R+++L  EQ+L +++QL     +Q+L  EQ+L R  +   EQ E++ +   E
Sbjct: 385  --REQQLRREQQLRREQQLRREQQLRR---EQQLRREQQLRREQQLRREQEEERHEQKHE 439

Query: 1713 ELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG 1772
            +  R QR      ++R  L+ E    R E E       R +EE R    +   +LE E  
Sbjct: 440  QERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEER---RERWLKLEEEER 496

Query: 1773 RFRELAEEAARLRALAEEAKRQR--QLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEA 1830
            R ++   E  +LR   EE + QR  +  EE+  +QR  +E+ L  +     E   LK E 
Sbjct: 497  REQQERRE-QQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQL-LKREE 554

Query: 1831 EIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQH--KADIEERLAQLRKASDSELERQK 1888
            E  L E+E   +RL+R  E+   Q  + EE+  Q   K + EERL Q  K  + E   Q+
Sbjct: 555  EKRL-EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQE 613

Query: 1889 GLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGR------IRSNAEDTLRSKEQ 1942
               E  L++    EE    L  S E+    + +L  E          R   E+ L  + +
Sbjct: 614  ERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLK 673

Query: 1943 AELEAARQRQLAAEEERRRREAEERVQKSLAA-EEEAARQRKAALEEVERLKAKVEEARR 2001
             E E  R+ Q  AEEE  + +A ER++  +   + +   +  A   +V     K E  RR
Sbjct: 674  REHEEERREQELAEEE--QEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRR 731

Query: 2002 LRERAEQESARQLQL---AQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLR 2058
             +E+ E+   R+ +L    +E A ++ Q EE+   F  Q + +E  +  +Q  S    LR
Sbjct: 732  RQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLR 791

Query: 2059 GEAEAARRAAE--EAEEARVQAEREAAQSRRQVEEAERLKQ--SAEEQAQARAQAQAAAE 2114
             + E   RA E  + E+  +  E E  Q RRQ  E E+  Q    EEQ Q R +AQ   E
Sbjct: 792  EQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQE 851

Query: 2115 KLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQVEQELTTLRLQ 2172
            +     E +  RR+Q ++   + +   + E +  +H  +A+  L+++ + EQ+L    LQ
Sbjct: 852  EEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQL----LQ 907

Query: 2173 LEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRAL 2232
             EE + Q+   +E  +R + E     R+  Q+++E   +  +  E  + + R     +  
Sbjct: 908  EEEEELQR---EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDK 964

Query: 2233 ILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2292
             L+ K+  ++ L EE EK ++   E         +    + L EE   ++R   E+  ++
Sbjct: 965  KLQQKE--EQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRK 1022

Query: 2293 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE--QMAQQLAEETQGFQRTLEAER 2350
            K +  QE  +L  E    +++K   QE+ R+ +E++E  Q  +QL  E +  +R  E ER
Sbjct: 1023 KDELQQEEEQLLRE----EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELER 1078

Query: 2351 Q--RQLEMSAEAERLKLRVAEMSR-----AQARAEEDAQRFRKQ-AEEIGEKLHRTELAT 2402
            Q  ++ E+  E E+L     E  R      Q R EE+ Q+  +Q   E  EK  R EL  
Sbjct: 1079 QYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELER 1138

Query: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQL 2462
            Q +       E ++   +   +R R+ +    RE+E+LQQE + L  + +E +  ++E+ 
Sbjct: 1139 QYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQ 1198

Query: 2463 LQETQALQQ------------------SFLSEKDSLL----------QRERFIEQEKAKL 2494
             +E + LQ+                   +  EK++ +          + E+F + E ++L
Sbjct: 1199 YREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQL 1258

Query: 2495 --EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
               Q  QD      + +E  + Q+++  Q+R R     E+  R + +  +   RK +E +
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318

Query: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSE 2591
            QL ++ R+++    E +++ RE+ QLL+E+    L   E
Sbjct: 1319 QLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQE 1357



 Score =  311 bits (797), Expect = 9e-84
 Identities = 327/1201 (27%), Positives = 577/1201 (48%), Gaps = 139/1201 (11%)

Query: 1447 GGAEGELQALRARAEEAEA--QKRQAQEEAERLR---RQVQDESQRKRQAEVELASRVKA 1501
            G A G  +  RAR +  E+  Q R+ +E+  R     RQ+++E  ++R+ + +   R  A
Sbjct: 90   GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149

Query: 1502 EAEAAREKQRALQAL------EELRLQAEE-AERRLRQAEVERARQVQVALETAQRSAEA 1554
            E E   EKQ  L+        EEL  Q +E  ER  R+AE E+ +  +   ET +   E 
Sbjct: 150  EGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCK-GHETEEFPDEE 208

Query: 1555 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQL 1614
            +L+ +      +  +L R  +EE     Q RE  +R  Q++ E E  + E     E  +L
Sbjct: 209  QLRRR------ELLELRRKGREE--KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKL 260

Query: 1615 KANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEK 1674
            +  E  R R   EE  Q + L + E  ++++E E++ +R  + ++   +Q E   ++ E+
Sbjct: 261  QEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEE 320

Query: 1675 QRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAE 1734
            +R+  E   QQ    EQ+L R         +Q +  E++L R Q E     Q R+E E E
Sbjct: 321  RREQQERREQQEERREQQLRR---------EQEERREQQLRREQEEERREQQLRREQEEE 371

Query: 1735 LAKVRAEMEVLLASKARAEEESRSTSE-KSKQRLEAEAGRFRELAEEAARLRALAEEAKR 1793
                R E ++    + R E++ R   + + +Q+L  E    RE  ++  R + L  E + 
Sbjct: 372  ----RREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRRE--QQLRREQQLRREQQL 425

Query: 1794 QRQLAEEDAARQRAEAERVLAEKLAAIGEATR--LKTEAEIALKEKEAENERLRRLAEDE 1851
            +R+  EE+   Q+ E ER   ++L    E  R  LK E E    E+E   ++L+R  E+E
Sbjct: 426  RRE-QEEERHEQKHEQER-REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEE 483

Query: 1852 AFQR-RRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKA 1910
              +R  +LEE+  + +   E R  QLR+  +   E+         R +RQ EEE L  + 
Sbjct: 484  RRERWLKLEEE--ERREQQERREQQLRREQEERREQ---------RLKRQEEEERLQQRL 532

Query: 1911 SFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ-LAAEEERRR----REAE 1965
              E+    + E            E  L+ +E+  LE  R+ Q L  E+E RR    +  E
Sbjct: 533  RSEQQLRREQE---------ERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREE 583

Query: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2025
            ER Q+ L  E+E   +++   EEVERL+ +    +RL+    +E  RQ  L  E  ++R 
Sbjct: 584  ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERR 643

Query: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLDQ-LRGEAEAARRAAEEAEEARVQAEREAAQ 2084
            Q + +      QQ+ +E +   ++E+  L+Q L+ E E  RR  E AEE + QA RE  +
Sbjct: 644  QQQLRRE----QQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA-RERIK 698

Query: 2085 SR--RQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAAD 2142
            SR  +   + E    + + +  +R + Q   E  R+  EQE  RR +  +   ++++ A 
Sbjct: 699  SRIPKWQWQLESEADARQSKVYSRPRKQ---EGQRRRQEQEEKRRRRESELQWQEEERAH 755

Query: 2143 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRS 2202
             + ++ ++  + T + +A+ + E    RL       +  L ++  ++L+AE  +   QR 
Sbjct: 756  RQQQEEEQRRDFTWQWQAEEKSERGRQRLSA-----RPPLREQRERQLRAEERQQREQRF 810

Query: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR-----FLQEEAEKMKQVAEE 2257
              EEE        E+  + + R E E     L +++  QR      LQEE + +++  ++
Sbjct: 811  LPEEE--------EKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQE--DQ 860

Query: 2258 AARLSVAAQEAARLRQLAEEDLAQQR-------ALAEKMLKEKMQAVQEATRLKAEAELL 2310
              R S   +   + R   EE+  ++R       AL E++ KE+    +E   L+ E    
Sbjct: 861  ERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE---- 916

Query: 2311 QQQKELAQEQARRLQEDK--EQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVA 2368
            +++K   QEQ R+ +E++  +Q  +QL  E +  +R  E ERQ + +   + +  +L   
Sbjct: 917  EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGE 976

Query: 2369 EMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLRE 2428
            E  + + +  E   R  ++ ++  E+L R E   + +    Q  E Q ++ D + ++  E
Sbjct: 977  EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR----QEWERQYRKKD-ELQQEEE 1031

Query: 2429 AIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIE 2488
             +   EREK +LQ+  +  Q + EE    ++EQLL E +  ++    E +   ++E  ++
Sbjct: 1032 QLLREEREKRRLQERER--QYREEEELQQEEEQLLGEERETRRR--QELERQYRKEEELQ 1087

Query: 2489 QEKAKLEQLFQDEVAK-AQQLREEQQRQQQQMEQERQRLVASMEEARR-----RQHEAEE 2542
            QE+   EQL ++E  K  +Q RE Q R++++++QE ++L+    E RR     RQ+  EE
Sbjct: 1088 QEE---EQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144

Query: 2543 GVRRKQEEL----------QQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEE 2592
             V++++E+L          Q+LE+Q R++EEL  EE Q LRE+ +   ++        EE
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204

Query: 2593 V 2593
            +
Sbjct: 1205 L 1205



 Score =  217 bits (553), Expect = 2e-55
 Identities = 251/968 (25%), Positives = 440/968 (45%), Gaps = 145/968 (14%)

Query: 1819 AIGEATRLKTE-------AEIALKEKEAENERLR-----RLAEDEAFQRRRLEEQ----- 1861
            A+G+AT L  E        E  L+++  E ++ R     R  E+E  QRRR + Q     
Sbjct: 88   ALGQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERE 147

Query: 1862 --AAQHKADIEERLAQL-RKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAG 1918
                + +++ +ERL Q  R+  D EL RQ+   ++   +RR  EE++ + K    +    
Sbjct: 148  LAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQER-EERRAEEEQLQSCKGHETEEFPD 206

Query: 1919 KAEL-ELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEER--RRREAEERVQKSLAAE 1975
            + +L   EL  +R       R ++Q +    + R    EEE+  R+RE   R ++    E
Sbjct: 207  EEQLRRRELLELRRKG----REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQE 262

Query: 1976 EEAARQRKAALEEVERLKAKVEEARRLRERAEQESAR-----QLQLAQEAAQKRLQAEEK 2030
            EE  RQR+   EE +  K + +E RR R+  EQ+  R     QL+  QE  ++  Q E +
Sbjct: 263  EEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERR 322

Query: 2031 AHAFAVQQKEQELQQTLQQEQSVL--DQLRGEAEAARR----AAEEAEEARVQAEREAAQ 2084
                  +Q+E+  +Q L++EQ      QLR E E  RR      E+ EE R Q  R   Q
Sbjct: 323  EQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQ 382

Query: 2085 SRRQ-----------VEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQE---------- 2123
             RR+            ++  R +Q   EQ   R Q     ++LR+E E+E          
Sbjct: 383  LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442

Query: 2124 AARRAQAEQAALRQKQAADAEMEKH-KKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNL 2182
              +R + EQ   R     + E E+H ++  +Q L++  + E+    L+L+ EE   Q+  
Sbjct: 443  REQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQER 502

Query: 2183 LDEELQRLKAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQR 2242
             +++L+R + E  E   +R + EE     R+Q    S+ + R E E R   L  ++  +R
Sbjct: 503  REQQLRREQEERREQRLKRQEEEE-----RLQQRLRSEQQLRREQEERREQLLKREEEKR 557

Query: 2243 FLQEEAE-KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQE-- 2299
              QE  E ++K+  EE     +  +E  R ++L  E   Q+  L +++ +E+++ +++  
Sbjct: 558  LEQERREQRLKREQEERRDQLLKREEERRQQRLKRE---QEERLEQRLKREEVERLEQEE 614

Query: 2300 --ATRLKAE-------AELL--QQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEA 2348
                RLK E        +LL  ++Q+E  Q+Q RR Q+++ +   +  EE +  ++ L+ 
Sbjct: 615  RREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKR 674

Query: 2349 ERQ---RQLEMSAE-----AERLKLRV------------AEMSRAQARAEEDAQRFRKQA 2388
            E +   R+ E++ E      ER+K R+            A  S+  +R  +   + R+Q 
Sbjct: 675  EHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQE 734

Query: 2389 EEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQ---QEAK 2445
            +E   +   +EL  QE+    +  + + Q+ D   +   E  +E  R++   +   +E +
Sbjct: 735  QEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR 794

Query: 2446 LLQLKSEEMQTVQQEQLLQETQALQQ-----------SFLSEKDSLLQRERFIEQEKAKL 2494
              QL++EE Q  +Q  L +E +  Q+            FL E++ L +RER  +Q + + 
Sbjct: 795  ERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRER-AQQLQEEE 853

Query: 2495 EQLFQDEVAKAQQLREEQQRQQQQMEQERQR-------LVASMEEARRRQ---HEAEEGV 2544
            + L +D+  +  Q +   Q+ + Q+E+ER+R         A  E+ R+ Q    E EE +
Sbjct: 854  DGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEEL 913

Query: 2545 RRKQEE---LQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601
            +R++ E    Q+ E+Q R++E+L  EE Q LRE+ +    Q R            Q    
Sbjct: 914  QREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQER----------ERQYRKD 963

Query: 2602 KTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILSAEELQRLAQ----GHTTV 2657
            K L    + L G   E       +   R+    + +E  +L  E  +R  Q     +   
Sbjct: 964  KKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKK 1023

Query: 2658 DELARRED 2665
            DEL + E+
Sbjct: 1024 DELQQEEE 1031



 Score = 96.3 bits (238), Expect = 6e-19
 Identities = 86/335 (25%), Positives = 166/335 (49%), Gaps = 42/335 (12%)

Query: 2250 KMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL 2309
            K+ Q    A   +    E  R R   +E L Q R       +E+ Q   E    + E E 
Sbjct: 80   KVAQACYYALGQATGLDEEKRARCDGKESLLQDRR------QEEDQRRFEPRDRQLEEEP 133

Query: 2310 LQQQKELAQEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAE 2369
             Q++++  QEQ R L E +EQ  +Q        +R  + +RQR+ E     E  + R   
Sbjct: 134  GQRRRQKRQEQERELAEGEEQSEKQ--------ERLEQRDRQRRDE-----ELWRQRQEW 180

Query: 2370 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREA 2429
              R + RAEE+  +  K  E         E   +E++   + LE++R+  +   ++ RE 
Sbjct: 181  QEREERRAEEEQLQSCKGHET-------EEFPDEEQLRRRELLELRRKGREEKQQQRRE- 232

Query: 2430 IAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRERFIEQ 2489
                   ++++ QE +  + +  E    ++E+ LQE +  +Q  L E++  L++   +E+
Sbjct: 233  ------RQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK---LER 283

Query: 2490 EKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQE 2549
            ++ + E+  Q+E  + Q+LR EQQ +++Q E+ R++     EE R +Q   E+   R+++
Sbjct: 284  QELRRER--QEEEQQQQRLRREQQLRRKQEEERREQ----QEERREQQERREQQEERREQ 337

Query: 2550 ELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHR 2584
            +L++ +++RR+Q+    +E +R  +QL+  +E+ R
Sbjct: 338  QLRREQEERREQQLRREQEEERREQQLRREQEEER 372



 Score = 37.4 bits (85), Expect = 0.34
 Identities = 73/313 (23%), Positives = 122/313 (38%), Gaps = 57/313 (18%)

Query: 359  EKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVER 418
            E+QL+ E E+L   +R   + Q      E Q  +   L Q + +LL  G+ P++    ER
Sbjct: 933  EEQLQQEEEQLLREEREKRRRQER----ERQYRKDKKLQQKEEQLL--GEEPEKRRRQER 986

Query: 419  DLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPA 478
            +  K      L   + Q L++ R  +  Q + R YR  + L     E  LR         
Sbjct: 987  E-KKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQ-EEEQLLR--------- 1035

Query: 479  TQVAQVTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRG 538
             +  +  LQ  +R+   E+   +  + LL    E + R +          +E Q      
Sbjct: 1036 EEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQE----------LERQYRKEEE 1085

Query: 539  LHQSIEEF-RAKIERARSDEGQLSPATRGAYRDCLGRLDLQYAK--LLNSSKARLRSLES 595
            L Q  E+  R + E+ R  E +         R C    +LQ  +  LL   + + R  E 
Sbjct: 1086 LQQEEEQLLREEPEKRRRQERE---------RQCREEEELQQEEEQLLREEREKRRRQEL 1136

Query: 596  LHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQN 655
               +             +EEEEV      +      ++E      +ELE + ++ +ELQ 
Sbjct: 1137 ERQY-------------REEEEV-----QQEEEQLLREEPEKRRRQELERQYREEEELQQ 1178

Query: 656  AGDRLLREDHPAR 668
              ++LLRE+   R
Sbjct: 1179 EEEQLLREEQEKR 1191


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score =  350 bits (899), Expect = 1e-95
 Identities = 430/1813 (23%), Positives = 770/1813 (42%), Gaps = 258/1813 (14%)

Query: 372  LQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLF 431
            L  +++++Q  A   E  + +    LQ D       +  Q   E  R L +A+ +++ LF
Sbjct: 39   LALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLF 98

Query: 432  NDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQR 491
             DV   +  +HPQ E++ + + +LHER+     EY    +  V  P              
Sbjct: 99   LDVDKARRLKHPQAEEIEKDIKQLHERVTQECAEYRALYEKMVLPPDVG----------- 147

Query: 492  RPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIE 551
             P ++ + +         +E+ Q +V   ++G  +  +E Q+  H  L + I+ +  ++ 
Sbjct: 148  -PRVDWARV---------LEQKQKQVCAGQYGPGMAELEQQIAEHNILQKEIDAYGQQL- 196

Query: 552  RARSDEGQLSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLN 611
              RS  G  +   R  YRD           LL ++  R +SL SL++ +   T++L  L 
Sbjct: 197  --RSLVGPDAATIRSQYRD-----------LLKAASWRGQSLGSLYTHLQGCTRQLSALA 243

Query: 612  EKEEEEVGFDWSDRNTNMTAKKESYSALMR-ELELKEKKIKELQNAGDRLLREDHPARPT 670
            E++   +  DWSD   +    +  Y    + EL  +E+ + +L++ G+R++   HPA   
Sbjct: 244  EQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGP 303

Query: 671  VESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCD 730
            +++ Q AL+ +W   L LC C E  L+    Y +F  +       L KL   L  KYS  
Sbjct: 304  IQAHQEALKMEWQNFLNLCICQETQLQHVEDYRRFQEEADSVSQTLAKLNSNLDAKYSPA 363

Query: 731  RSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKRAKAVVQLKPRHPAHPMRGRLPLLAV 790
                     +LLQ  + E+++L   +     L +R++ V  L  R   +P +  L + ++
Sbjct: 364  PGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRR--NPPQQPLHVDSI 421

Query: 791  CDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRL 850
            CD+   EV + +G+  +LV    P  W V    G     P+ CF +P P+ +A    +RL
Sbjct: 422  CDWDSGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRL 481

Query: 851  EAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLKPEEQRQALHSLELH 910
             ++ QAL      +   +K+  A +SLR   Q      LA      P+ Q+       L 
Sbjct: 482  ASELQALKQKLATVQSRLKA-SAVESLRPSQQAPSGSDLA-----NPQAQKLLTQMTRLD 535

Query: 911  YQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDI 970
                       G  G  +R                  Q L       SR     + L+D+
Sbjct: 536  -----------GDLGQIER------------------QVLAWARAPLSR----PTPLEDL 562

Query: 971  RLQLEACETRTVHRLRLPLDKEPA-RECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVL 1029
              ++ + E        L  +KE A +EC   ++ +    A                   L
Sbjct: 563  EGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPVGPA------------------AL 604

Query: 1030 ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEK-LKTISLVIRGTQGAEEVLRAHEE 1088
             LP    +     S++++ L  L   ++ +A+ LE+ ++    VIRG           E 
Sbjct: 605  QLPVALNSVKNKFSDVQV-LCSLYGEKAKAALDLERQIQDADRVIRG----------FEA 653

Query: 1089 QLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGER 1148
             L +   +PA    L+   + L++ R +   QQ     L   L+ ++     LQ    E 
Sbjct: 654  TLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQNNFQEF 713

Query: 1149 DVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQ 1208
              ++ R + +V  L +R+ AV  Q D+R++ ++      + ++   D L +WL+   R  
Sbjct: 714  CQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQFKNCKDNLSSWLEHLPRS- 772

Query: 1209 EQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYK 1268
               Q  P      +  +L+ ++ L +EI+            ++    A++DYELQ  TY+
Sbjct: 773  ---QVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAALQDYELQADTYR 829

Query: 1269 AQLEP--VASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYI------------KF 1314
              LEP    S  K+P+V    ES+  +  +L   Y+E+     Q +            K 
Sbjct: 830  CSLEPTLAVSAPKRPRVAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKE 889

Query: 1315 ISETLRRMEE-------------EERLAEQQRAEERERLAEVEAALEKQR-QLAEAHAQA 1360
            +SE +RR  +             E    + Q  EER+R+A V+  LE QR QL +   Q 
Sbjct: 890  LSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVARVQHELEAQRSQLLQLRTQ- 948

Query: 1361 KAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEA 1420
                 R  + L+++   E  R  +      + K  ++EE ++ R   +A+++  A++   
Sbjct: 949  -----RPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKR-RAGLQADLEVAAQKVVQ 1002

Query: 1421 AERSRLRIEEEIRVVRLQLEATERQRG-GAEGELQALRARAEEAEAQKRQAQEEAERLRR 1479
             E  R  ++  +    L  E T+ +R  G + +   LR + ++   +        E L++
Sbjct: 1003 LESKRKTMQPHL----LTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKK 1058

Query: 1480 QVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERAR 1539
            ++   +  KR+ +V+    VK E     +    ++A + LRLQ EE   R +QAE E   
Sbjct: 1059 ELL--ALEKREVDVKEKVVVK-EVVKVEKNLEMVKAAQALRLQMEEDAARRKQAE-EAVA 1114

Query: 1540 QVQVALETAQRS----------AEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE 1589
            ++Q  +E  +R+           E +   +     +++++L   L+EE    A L  E  
Sbjct: 1115 KLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELS 1174

Query: 1590 RRAQQQAEAERAREEA---ERELERWQL---KANEALRLRLQAEEVAQQKSLAQAEAEKQ 1643
                + +  E+ R +    ER  E +Q+      E  RL+ + +E+A ++S  + E EK 
Sbjct: 1175 DLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLKAKLQEMAGKRSGVEKEVEKL 1234

Query: 1644 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQG 1703
              + E       +A++  V  +E+ ++ +  +R              +E+ RL+A+  + 
Sbjct: 1235 LPDLEVL-----RAQKPTVEYKEVTQEVVRHERS---------PEVLREIDRLKAQLNEL 1280

Query: 1704 EQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1763
                   +E+L RLQ E       R E   E    RA++E    SK     E        
Sbjct: 1281 VNSHGRSQEQLIRLQGE-------RDEWRRE----RAKVETKTVSKEVVRHEKDPV---- 1325

Query: 1764 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEA 1823
               LE EA R R+   EAA+ R  AE+A  + Q       R++ E + V+ E +      
Sbjct: 1326 ---LEKEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV----- 1377

Query: 1824 TRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEER--LAQLRKASD 1881
                T+ +  L+E   E+ RL    ++E  +RR+LE +  Q +A +EE+  L   ++   
Sbjct: 1378 ----TQKDPKLRE---EHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRS 1430

Query: 1882 SELERQKGLVEDTLR-----------QRRQVEEEILALKASFEKAAAGKAELELELGRIR 1930
             +L  ++ L + TLR           Q + + EE++ L+   +   + +A L  +L + +
Sbjct: 1431 KKLAVERELRQLTLRIQELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEA-LRWDLDQEK 1489

Query: 1931 SNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVE 1990
            +   +  R  +  +++    ++  ++E+   +E   RVQK    E+E AR  +    E  
Sbjct: 1490 TQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEV-IRVQKDRVLEDERARVWEMLNRERT 1548

Query: 1991 RLKAKVEEARRLRERAEQ---------ESARQLQLAQEAAQK---RLQAEEKAHAFAVQQ 2038
              +A+ EEARRLRER ++             +LQ A++ A +   RLQ E +A       
Sbjct: 1549 ARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRA------L 1602

Query: 2039 KEQELQQTLQ-QEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAER--- 2094
            + Q+ QQTLQ QE+S L   + E+E  + A    E +R++A     + + Q+ E ER   
Sbjct: 1603 ERQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEA--AILREKDQIYEKERTLR 1660

Query: 2095 ---LKQSAEEQAQ 2104
                K S EE +Q
Sbjct: 1661 DLHAKVSREELSQ 1673



 Score =  264 bits (675), Expect = 1e-69
 Identities = 150/361 (41%), Positives = 226/361 (62%), Gaps = 8/361 (2%)

Query: 4099 LKEKKRERKTSSKSSVRKRRVVIVDPETGKEMSVYEAYRKGLIDHQTYLELSEQECEWEE 4158
            +  ++  ++T ++ +    ++ I++PETGK+MS YEAY++G+ID   YL+L E EC+WEE
Sbjct: 1666 VSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEE 1725

Query: 4159 ITISSSDGVVKSMIIDRRSGRQYDIDDAIAKNLIDRSALDQYRAGTLSITEFADMLSGNA 4218
            +T S   G  +S+++DR+SG+QY I+ A+    I +     Y+ G L I+EFA +++G  
Sbjct: 1726 VTTSGPCGE-ESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGET 1784

Query: 4219 GGFRSRSSSVGS--SSSYPISPAVSRTQLASWSDPT---EETGPVAGILDTETLEKVSIT 4273
                S S S+GS  S S   SPA   T   S S      +++ P+AGI DT T  K SI 
Sbjct: 1785 KP--SSSLSIGSIISKSPLASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCSIK 1842

Query: 4274 EAMHRNLVDNITGQRLLEAQACTGGIIDPSTGERFPVTDAVNKGLVDKIMVDRINLAQKA 4333
             A+ +N++D ITGQ+LLEAQA TGGI+D  + ER+ V  A+ +GL++     R+  AQKA
Sbjct: 1843 TAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKA 1902

Query: 4334 FCGFEDPRTKTKMSAAQALKKGWLYYEAGQRFLEVQYLTGGLIEPDTPGRVPLDEALQRG 4393
            F G EDP TK ++S  +A++KGW+  E+    L+VQ+LTGGLI+P   GR+P+ +AL  G
Sbjct: 1903 FTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSG 1962

Query: 4394 TVDARTAQKLRDVGAYSKYLTCPKTKLKISYKDALDRSMVEEGTGLRLLEAAAQSTKGYY 4453
             +    AQ L+D  +Y K LT P +K ++SYK+A+ R   +  +GL LL AA +  + Y 
Sbjct: 1963 MISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAALEGYRCYR 2022

Query: 4454 S 4454
            S
Sbjct: 2023 S 2023



 Score =  260 bits (664), Expect = 2e-68
 Identities = 458/2092 (21%), Positives = 840/2092 (40%), Gaps = 324/2092 (15%)

Query: 1012 EGLGKGV-ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTIS 1070
            +GL KG   + S +       P+ SP+  +  +  EL L       +   +  + L+T  
Sbjct: 3    KGLSKGSQGKGSPKGSPAKGSPKGSPSRHSRAATQELALLISRMQANADQVERDILETQK 62

Query: 1071 LVIRGTQGAEEVLRAHEEQ-----LKEAQAVPATL------------PELEATKASLKKL 1113
             + +    +E+      +Q     LKEA+ +   L            P+ E  +  +K+L
Sbjct: 63   RLQQDRLNSEQSQALQHQQETGRSLKEAEVLLKDLFLDVDKARRLKHPQAEEIEKDIKQL 122

Query: 1114 RAQAEAQQPTFDALRDELRGAQEVGER------LQQRHGERDVEVERWRERVAQLLERWQ 1167
              +   +   + AL +++    +VG R      L+Q+  ++ V   ++   +A+L ++  
Sbjct: 123  HERVTQECAEYRALYEKMVLPPDVGPRVDWARVLEQK--QKQVCAGQYGPGMAELEQQ-- 178

Query: 1168 AVLAQTDVRQRELEQLGRQLR------------YYRE---------------------SA 1194
              +A+ ++ Q+E++  G+QLR             YR+                       
Sbjct: 179  --IAEHNILQKEIDAYGQQLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCT 236

Query: 1195 DPLGAWLQDARRRQEQIQAMPLADSQAVR---------EQLRQEQALLEEIERHGEKVEE 1245
              L A  +  RR  +Q  +  +AD   VR         E L QEQ++  ++E  GE++ E
Sbjct: 237  RQLSALAEQQRRILQQDWSDLMADPAGVRREYEHFKQHELLSQEQSV-NQLEDDGERMVE 295

Query: 1246 CQRFAKQYINAIKD---YELQ-----LVTYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1297
             +  A   I A ++    E Q      +  + QL+ V    +    Q  ++SV Q    L
Sbjct: 296  LRHPAVGPIQAHQEALKMEWQNFLNLCICQETQLQHVEDYRR---FQEEADSVSQTLAKL 352

Query: 1298 RTHY-SELTTLTSQYIKFISETLRRME-EEERLAEQQRAE-ERERLAEVEAALEKQRQLA 1354
             ++  ++ +          +E L+++E EE+RLA  +RA  + +R +   A L ++R   
Sbjct: 353  NSNLDAKYSPAPGGPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPP 412

Query: 1355 EAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAK 1414
            +      +  + ++ E+Q    E    R +   +       +Q    + +++  A     
Sbjct: 413  QQPLHVDSICDWDSGEVQLLQGE----RYKLVDNTDPHAWVVQGPGGETKRAPAACFCIP 468

Query: 1415 ARQAEAAERSRLRIEEEIRVVRLQLEATE-RQRGGAEGELQALRARAEEAEAQKRQAQEE 1473
            A   +A  R+  R+  E++ ++ +L   + R +  A   L+  +     ++    QAQ+ 
Sbjct: 469  APDPDAVARAS-RLASELQALKQKLATVQSRLKASAVESLRPSQQAPSGSDLANPQAQKL 527

Query: 1474 AERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALE---------ELRLQAE 1524
              ++ R   D  Q +RQ        V A A A   +   L+ LE           RLQ+ 
Sbjct: 528  LTQMTRLDGDLGQIERQ--------VLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSL 579

Query: 1525 EAERRLRQAEVER----------ARQVQVALETAQRSAEAELQSKRASFAEKTA---QLE 1571
              E+   Q E E           A Q+ VAL + +    +++Q   + + EK      LE
Sbjct: 580  GTEKETAQKECEAFLSTRPVGPAALQLPVALNSVKNKF-SDVQVLCSLYGEKAKAALDLE 638

Query: 1572 RSLQEEHVAV----AQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1627
            R +Q+    +    A L +EA   A+  A  ER    +E + +R +L   +   LRL   
Sbjct: 639  RQIQDADRVIRGFEATLVQEAPIPAEPGALQERV---SELQRQRRELLEQQTCVLRLHRA 695

Query: 1628 EVAQQKSLAQAEAEKQK--EEAEREARR------RGKAEEQAVRQRELAEQELEKQRQLA 1679
              A + + A  +   Q+  ++  R+ R+      R  A    +  RE   Q+     Q  
Sbjct: 696  LKASEHACAALQNNFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREKVVQDAALTYQQF 755

Query: 1680 EGTAQQRLAAEQELIRLRAETEQGEQQ-------RQLLEEELARLQREAAAATQKRQELE 1732
            +       +  + L R +     G  Q       ++ L +E+   +R+ A A+   Q L+
Sbjct: 756  KNCKDNLSSWLEHLPRSQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQ 815

Query: 1733 AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAK 1792
            A L     + +    S     E + + S   + R+       +  A+E    +A  E A 
Sbjct: 816  AALQDYELQADTYRCSL----EPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAA 869

Query: 1793 RQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEA 1852
             Q+QL ++    ++   ++ L+E +    +A +       A +E EA   +L    +  A
Sbjct: 870  AQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQGSESPAQAGRESEALKAQLEEERKRVA 929

Query: 1853 FQRRRLEEQAAQH-KADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEE---ILAL 1908
              +  LE Q +Q  +   +  L +L +    E  R   L     R + QVEEE      L
Sbjct: 930  RVQHELEAQRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVEEEGKRRAGL 989

Query: 1909 KASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEA-----ARQRQLAAEEERRRRE 1963
            +A  E AA    +LE +    R   +  L +KE  ++E      ++  QL  + ++ R E
Sbjct: 990  QADLEVAAQKVVQLESK----RKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGE 1045

Query: 1964 AE------ERVQKSLAAEE--EAARQRKAALEEVERLKAKVE---EARRLRERAEQESAR 2012
                    E ++K L A E  E   + K  ++EV +++  +E    A+ LR + E+++AR
Sbjct: 1046 DAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAAR 1105

Query: 2013 QLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAE 2072
            + Q  +  A+ + + E+   A +  + +  +++  + EQ     L  E+   R   EE  
Sbjct: 1106 RKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQD--PGLLQESSRLRSLLEEER 1163

Query: 2073 EARVQAEREAAQ--SRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQA 2130
                   RE +   S+  V E +R K   +E+     Q          E EQE  R    
Sbjct: 1164 TKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDP-------ETEQEITRLKAK 1216

Query: 2131 EQAALRQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRL 2190
             Q    ++   + E+EK     E    QK  VE +  T  +   E   +   +  E+ RL
Sbjct: 1217 LQEMAGKRSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPE---VLREIDRL 1273

Query: 2191 KAEATEAARQRSQVEEELFSVRVQMEELSKLKARIEAE--NRALILRDKDNTQRFLQEEA 2248
            KA+  E      + +E+L  ++ + +E  + +A++E +  ++ ++  +KD     L++EA
Sbjct: 1274 KAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPV---LEKEA 1330

Query: 2249 EKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAE 2308
            E+++Q   EAA+   AA++A         +L  +R L E+   E+   VQE    + + +
Sbjct: 1331 ERLRQEVREAAQKRRAAEDAVY-------ELQSKRLLLERRKPEEKVVVQEVVVTQKDPK 1383

Query: 2309 LLQQQKELA----QEQARRLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLK 2364
            L ++   L+    +E  RR Q + E    +   E Q    + + +R ++L +  E  +L 
Sbjct: 1384 LREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLT 1443

Query: 2365 LRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAE 2424
            LR+ E+               K+   + EK+   E+   EK      LE   +    D +
Sbjct: 1444 LRIQELE--------------KRPPTVQEKIIMEEVVKLEKDP---DLEKSTEALRWDLD 1486

Query: 2425 RLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2484
            + +  + EL RE + LQ +  +LQ    + +T+ +E +  +   + +   +    +L RE
Sbjct: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTIYKEVIRVQKDRVLEDERARVWEMLNRE 1546

Query: 2485 RFIEQEKAKLEQLFQDEVAKAQQL-----REEQ--QRQQQQMEQERQRLVASMEEARRRQ 2537
            R   Q + +  +  ++ + +A+ L     REE   QR + Q +QE  RL    +E R  +
Sbjct: 1547 RTARQAREEEARRLRERIDRAETLGRTWSREESELQRARDQADQECGRL---QQELRALE 1603

Query: 2538 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRL--------REQLQLLEEQH------ 2583
             + ++   + QEE + L Q+   + +  A+  Q L        RE+ Q+ E++       
Sbjct: 1604 RQKQQQTLQLQEESKLLSQKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLH 1663

Query: 2584 ----RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDG------------- 2626
                R  L+   +   + ++   ++       D    EA      D              
Sbjct: 1664 AKVSREELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDW 1723

Query: 2627 ---------------LRRKVSAQRLQEAGI----LSAEELQRLAQGHTTVDELARREDVR 2667
                           L RK   Q   EA +    +S EE      GH  + E A      
Sbjct: 1724 EEVTTSGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGE 1783

Query: 2668 HYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASGFLLDPVRNRRLT 2727
                   SI  ++ K+    L+  A       SP  +L L +       + D   + + +
Sbjct: 1784 TKPSSSLSIGSIISKSP---LASPAPQSTSFFSPSFSLGLGDDSFPIAGIYDTTTDNKCS 1840

Query: 2728 VNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQAMQKGLIVREHGIRLLEAQ 2787
            +  AV + ++ P    KLL A+ A  G  D  + ++ S+ +AM++GLI      RLL AQ
Sbjct: 1841 IKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQ 1900

Query: 2788 IA--------------------------------------TGGVIDPVHSHRVPVDVAYR 2809
             A                                      TGG+IDP  + R+P+  A  
Sbjct: 1901 KAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALL 1960

Query: 2810 RGYFDEEMNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLP 2861
             G   EE+ ++L D S   K   DP + E L+Y + + RC +DP +GL LLP
Sbjct: 1961 SGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012



 Score =  215 bits (548), Expect = 7e-55
 Identities = 478/2130 (22%), Positives = 841/2130 (39%), Gaps = 309/2130 (14%)

Query: 1550 RSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQ--LREEAERRAQQQAEAERAREEAER 1607
            R+A  EL    +       Q+ER + E    + Q  L  E  +  Q Q E  R+ +EAE 
Sbjct: 33   RAATQELALLISRMQANADQVERDILETQKRLQQDRLNSEQSQALQHQQETGRSLKEAEV 92

Query: 1608 ELERWQLKANEALRLRL-QAEEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRE 1666
             L+   L  ++A RL+  QAEE+  +K + Q      +E AE  A          V  R 
Sbjct: 93   LLKDLFLDVDKARRLKHPQAEEI--EKDIKQLHERVTQECAEYRALYEKMVLPPDVGPRV 150

Query: 1667 LAEQELE-KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAAT 1725
               + LE KQ+Q+  G     +A          E EQ   +  +L++E+       A   
Sbjct: 151  DWARVLEQKQKQVCAGQYGPGMA----------ELEQQIAEHNILQKEID------AYGQ 194

Query: 1726 QKRQELEAELAKVRAEMEVLLASKARAEEE-----------SRSTSEKSKQRLEAEAGRF 1774
            Q R  +  + A +R++   LL + +   +            +R  S  ++Q+       +
Sbjct: 195  QLRSLVGPDAATIRSQYRDLLKAASWRGQSLGSLYTHLQGCTRQLSALAEQQRRILQQDW 254

Query: 1775 RELAEEAARLRALAEEAKRQRQLAEEDAARQ-RAEAERVLAEKLAAIG----EATRLKTE 1829
             +L  + A +R   E  K+   L++E +  Q   + ER++  +  A+G        LK E
Sbjct: 255  SDLMADPAGVRREYEHFKQHELLSQEQSVNQLEDDGERMVELRHPAVGPIQAHQEALKME 314

Query: 1830 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKG 1889
             +  L     +  +L+ + +      RR +E+A      + + LA+L    D++     G
Sbjct: 315  WQNFLNLCICQETQLQHVED-----YRRFQEEADS----VSQTLAKLNSNLDAKYSPAPG 365

Query: 1890 L---VEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1946
                    L Q+ + EE+ LA+          ++     L + R+  +  L      + +
Sbjct: 366  GPPGAPTELLQQLEAEEKRLAVTERATGDLQRRSRDVAPLPQRRNPPQQPLHVDSICDWD 425

Query: 1947 AARQRQLAAEE-------------------ERRRREAE---------ERVQKS--LAAEE 1976
            +   + L  E                    E +R  A          + V ++  LA+E 
Sbjct: 426  SGEVQLLQGERYKLVDNTDPHAWVVQGPGGETKRAPAACFCIPAPDPDAVARASRLASEL 485

Query: 1977 EAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAV 2036
            +A +Q+ A ++   RLKA   E+ R  ++A   S     LA   AQK L    +      
Sbjct: 486  QALKQKLATVQS--RLKASAVESLRPSQQAPSGS----DLANPQAQKLLTQMTRLDGDLG 539

Query: 2037 QQKEQELQ--QTLQQEQSVLDQLRG-----EAEAARRAAEEAEEARVQAEREAAQSRRQV 2089
            Q + Q L   +      + L+ L G     E  A R  +   E+   Q E EA  S R V
Sbjct: 540  QIERQVLAWARAPLSRPTPLEDLEGRIHSHEGTAQRLQSLGTEKETAQKECEAFLSTRPV 599

Query: 2090 EEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAALRQKQAADAEMEKHK 2149
              A      A    + +         L  E       +A+A     RQ Q AD  +    
Sbjct: 600  GPAALQLPVALNSVKNKFSDVQVLCSLYGE-------KAKAALDLERQIQDADRVIRGF- 651

Query: 2150 KFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEEL-------QRLKAEATEAARQRS 2202
               E TL Q+A +  E   L+ ++ E   Q+  L E+        + LKA     A  ++
Sbjct: 652  ---EATLVQEAPIPAEPGALQERVSELQRQRRELLEQQTCVLRLHRALKASEHACAALQN 708

Query: 2203 QVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLS 2262
              +E    +  Q  ++  L  R  A    L LR+K      +Q+ A   +Q       LS
Sbjct: 709  NFQEFCQDLPRQQRQVRALTDRYHAVGDQLDLREK-----VVQDAALTYQQFKNCKDNLS 763

Query: 2263 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR 2322
               +   R  Q+   D   Q A   +  K   Q +Q   R +A A  L Q  + A  Q  
Sbjct: 764  SWLEHLPR-SQVRPSDGPSQIAYKLQAQKRLTQEIQSRERDRATASHLSQALQAAL-QDY 821

Query: 2323 RLQEDKEQMAQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQ 2382
             LQ D  + + +        +R   A  Q  ++  A+ + L     E++ AQ +  +  +
Sbjct: 822  ELQADTYRCSLEPTLAVSAPKRPRVAPLQESIQ--AQEKNLAKAYTEVAAAQQQLLQQLE 879

Query: 2383 RFRKQAE--EIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKE-- 2438
              RK  E  E+ E + RT                      HDA++  E+ A+  RE E  
Sbjct: 880  FARKMLEKKELSEDIRRT----------------------HDAKQGSESPAQAGRESEAL 917

Query: 2439 --KLQQEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSL-LQRERFIEQEKAKLE 2495
              +L++E K +     E++  Q+ QLLQ         L EK+ +   R+  +E   ++++
Sbjct: 918  KAQLEEERKRVARVQHELEA-QRSQLLQLRTQRPLERLEEKEVVEFYRDPQLEGSLSRVK 976

Query: 2496 QLFQDEVAKAQQLREEQQRQQQ---QMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQ 2552
               ++E  +   L+ + +   Q   Q+E +R+ +   +      Q E + G+  +  +L+
Sbjct: 977  AQVEEEGKRRAGLQADLEVAAQKVVQLESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLR 1036

Query: 2553 QLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAATKTLPNGRDALD 2612
               QQ R ++ +++   + L+++L  LE++    +   E+V   +V   K   N      
Sbjct: 1037 IQIQQLRGEDAVISARLEGLKKELLALEKRE---VDVKEKVVVKEVV--KVEKNLEMVKA 1091

Query: 2613 GPAAEAEPEHSFDGLRRKVSAQRLQ--EAGILSAEELQRLAQGHTTVDELARREDVRHYL 2670
              A   + E   D  RRK + + +   +A I   E      +    V E+ + E     L
Sbjct: 1092 AQALRLQMEE--DAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLL 1149

Query: 2671 QGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG---------FLLDPV 2721
            Q  S +  LL     E+ +  A L R+L    +   ++E Q             F +DP 
Sbjct: 1150 QESSRLRSLL----EEERTKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPE 1205

Query: 2722 RNRRLTVNEAVKEGVVG-------------PELHHKLLSAERAVTGYKD----------- 2757
              + +T  +A  + + G             P+L  ++L A++    YK+           
Sbjct: 1206 TEQEITRLKAKLQEMAGKRSGVEKEVEKLLPDL--EVLRAQKPTVEYKEVTQEVVRHERS 1263

Query: 2758 PYTGQQISLFQAMQKGLIVREHGIRLLEAQIATGGVIDPVHSHRVPVDV-AYRRGYFDEE 2816
            P   ++I   +A Q   +V  HG R  E  I   G  D     R  V+     +     E
Sbjct: 1264 PEVLREIDRLKA-QLNELVNSHG-RSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHE 1321

Query: 2817 MNRVLADPSDDTKGFFDPNTHENLTYLQLLERCVEDPETGLCLLPLTDKAAKG--GELVY 2874
             + VL   ++  +        E     +  E  V + ++   LL       K    E+V 
Sbjct: 1322 KDPVLEKEAERLR----QEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVV 1377

Query: 2875 TDSEARDVFEKATVSAPFGKFQGKTVTIWEIINSEYFTAEQRRDLL--RQFRTGRITVEK 2932
            T  + +   E + +S    +  G+   +   +       E++  LL  ++ R+ ++ VE+
Sbjct: 1378 TQKDPKLREEHSRLSGSLDEEVGRRRQLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVER 1437

Query: 2933 IIKIIITVVEEQEQKGRLCFEGLRSLVPAAELLESRVIDRELYQQLQRGERSVR-----D 2987
             ++ +   ++E E++     E         +++   V+  E    L++   ++R     +
Sbjct: 1438 ELRQLTLRIQELEKRPPTVQE---------KIIMEEVVKLEKDPDLEKSTEALRWDLDQE 1488

Query: 2988 VAEVDTVRRALRGANVIAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIID 3047
              +V  + R  +   V   V  +   Q+ +IY    K+++       L + +A    +++
Sbjct: 1489 KTQVTELNRECKNLQVQIDVLQKAKSQEKTIY----KEVIRVQKDRVLEDERARVWEMLN 1544

Query: 3048 PATSARLTVDEAVR--------AGLVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALK 3099
               +AR   +E  R        A  +G  +  +    ++A    RD    +   L Q L+
Sbjct: 1545 RERTARQAREEEARRLRERIDRAETLGRTWSREESELQRA----RDQADQECGRLQQELR 1600

Query: 3100 KGLIPREQGLRLLDAQLSTGGIVDPSKSHRVPLDVACARGCLDEETSRALSAPRADAKAY 3159
               + R++  + L  Q  +  +   ++S R     A  RG   +E SR            
Sbjct: 1601 A--LERQKQQQTLQLQEESKLLSQKTESER---QKAAQRG---QELSRL----------- 1641

Query: 3160 SDPSTGEPATYGELQQRCRPDQLTGLSLLPLSEKAARARQEELYSELQARETFEKTPVEV 3219
                  E A   E  Q    ++        L +  A+  +EEL  E Q RET   T + +
Sbjct: 1642 ------EAAILREKDQIYEKERT-------LRDLHAKVSREELSQETQTRETNLSTKISI 1688

Query: 3220 ----------PVGGFK------GRTVTV------WELISSEYFTAEQRQELLRQFRTGK- 3256
                      P   +K      G+ + +      WE +++     E+   +L   ++GK 
Sbjct: 1689 LEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTTSGPCGEE--SVLLDRKSGKQ 1746

Query: 3257 VTVEKVIKILITIVEEVETLRQERLSFSGLRAPV-----PASELLASGVLSRAQFEQLKD 3311
             ++E  ++      EE    +   L  S     V     P+S L    ++S++       
Sbjct: 1747 YSIEAALRCRRISKEEYHLYKDGHLPISEFALLVAGETKPSSSLSIGSIISKSPLASPAP 1806

Query: 3312 GKTTVKDLS-ELGSVRTLLQGSGCLAGIYLEDTKEKVSIYEAMRRGLLRATTAALLLEAQ 3370
              T+    S  LG    L   S  +AGIY   T  K SI  A+ + +L   T   LLEAQ
Sbjct: 1807 QSTSFFSPSFSLG----LGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQ 1862

Query: 3371 AATGFLVDPVRNQRLYVHEAVKAGVVGPELHEQLLSAEKAVTGYRDPYSGSTISLFQAMQ 3430
            AATG +VD +  +R  VH+A++ G++     ++LL+A+KA TG  DP +   +S+ +A+Q
Sbjct: 1863 AATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQ 1922

Query: 3431 KGLVLRQHGIRLLEAQIATGGIIDPVHSHRVPVDVAYQRGYFSEEMNRVLADPSDDTKGF 3490
            KG + R+  +  L+ Q  TGG+IDP  + R+P+  A   G  SEE+ ++L D S   K  
Sbjct: 1923 KGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDL 1982

Query: 3491 FDPNTHENLTYRQLLERCVEDPETGLRLLP 3520
             DP + E L+Y++ + RC +DP +GL LLP
Sbjct: 1983 TDPISKERLSYKEAMGRCRKDPLSGLLLLP 2012



 Score =  132 bits (331), Expect = 1e-29
 Identities = 68/186 (36%), Positives = 116/186 (62%)

Query: 3913 IAGVFVDATKERLSVYQAMKKGIIRPGTAFELLEAQAATGYVIDPIKGLKLTVEEAVRMG 3972
            IAG++   T  + S+  A+ K ++ P T  +LLEAQAATG ++D +   + +V +A+  G
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886

Query: 3973 IVGPEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIID 4032
            ++      +LL+A++A TG +DP + K +S+ +A++KG + ++  +  L+ Q  TGG+ID
Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946

Query: 4033 PEESHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMERCITDPQT 4092
            P+ + R+P++ A   G+  EE+ ++L D S   K   DP ++E L+Y + M RC  DP +
Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006

Query: 4093 GLCLLP 4098
            GL LLP
Sbjct: 2007 GLLLLP 2012



 Score =  127 bits (320), Expect = 2e-28
 Identities = 73/193 (37%), Positives = 111/193 (57%)

Query: 3004 IAGVWLEEAGQKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAG 3063
            IAG++      K SI  A+ K++L       LLEAQA TG I+D  +  R +V +A+  G
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886

Query: 3064 LVGPEFHEKLLSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQLSTGGIVD 3123
            L+     ++LL+A+KA TG  DP T + +S+ +A++KG +PRE  L  L  Q  TGG++D
Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946

Query: 3124 PSKSHRVPLDVACARGCLDEETSRALSAPRADAKAYSDPSTGEPATYGELQQRCRPDQLT 3183
            P ++ R+P+  A   G + EE ++ L    +  K  +DP + E  +Y E   RCR D L+
Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006

Query: 3184 GLSLLPLSEKAAR 3196
            GL LLP + +  R
Sbjct: 2007 GLLLLPAALEGYR 2019



 Score =  121 bits (304), Expect = 1e-26
 Identities = 69/186 (37%), Positives = 110/186 (59%), Gaps = 1/186 (0%)

Query: 3670 VAGVYLPGSRQTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKG 3729
            +AG+Y   +    SI  A+ K +L     + LLEAQAATG ++D +  ER +V +A+ +G
Sbjct: 1827 IAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLSRERYSVHKAMERG 1886

Query: 3730 LVGPELHDRLLSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQLATGGIVD 3789
            L+      RLL+A++A TG  DP T++ +S+ +A++K  +P E  L  L  Q  TGG++D
Sbjct: 1887 LIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLID 1946

Query: 3790 PRLGFHLPLEVAYQRGYLNKDTHDQL-SEPSEVRSYVDPSTDERLSYTQLLRRCRRDDGT 3848
            P+    +P++ A   G ++++    L  E S  +   DP + ERLSY + + RCR+D  +
Sbjct: 1947 PKRTGRIPIQQALLSGMISEELAQLLQDESSYEKDLTDPISKERLSYKEAMGRCRKDPLS 2006

Query: 3849 GQLLLP 3854
            G LLLP
Sbjct: 2007 GLLLLP 2012



 Score = 52.8 bits (125), Expect = 8e-06
 Identities = 39/163 (23%), Positives = 73/163 (44%), Gaps = 5/163 (3%)

Query: 2959 VPAAELLESRVIDRELYQQLQRGERSV-----RDVAEVDTVRRALRGANVIAGVWLEEAG 3013
            +   +LLE++     +   L R   SV     R + E  + +R L       G+      
Sbjct: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912

Query: 3014 QKLSIYNALKKDLLPSDMAVALLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPEFHEKL 3073
            ++LS+  A++K  +P +  +  L+ Q  TG +IDP  + R+ + +A+ +G++  E  + L
Sbjct: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972

Query: 3074 LSAEKAVTGYRDPYTGQSVSLFQALKKGLIPREQGLRLLDAQL 3116
                       DP + + +S  +A+ +       GL LL A L
Sbjct: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015



 Score = 52.4 bits (124), Expect = 1e-05
 Identities = 42/163 (25%), Positives = 75/163 (46%), Gaps = 5/163 (3%)

Query: 3625 LTAEDLFEARIISLETYNLLREGTRSLREALEA-----ESAWCYLYGTGSVAGVYLPGSR 3679
            +T + L EA+  +    +LL     S+ +A+E       S    L    +  G+  P ++
Sbjct: 1853 ITGQKLLEAQAATGGIVDLLSRERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTK 1912

Query: 3680 QTLSIYQALKKGLLSAEVARLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3739
            + LS+ +A++KG +  E     L+ Q  TG L+DP +  R+ + +A+  G++  EL   L
Sbjct: 1913 KRLSVGEAVQKGWMPRESVLPHLQVQHLTGGLIDPKRTGRIPIQQALLSGMISEELAQLL 1972

Query: 3740 LSAERAVTGYRDPYTEQTISLFQAMKKELIPTEEALRLLDAQL 3782
                       DP +++ +S  +AM +        L LL A L
Sbjct: 1973 QDESSYEKDLTDPISKERLSYKEAMGRCRKDPLSGLLLLPAAL 2015



 Score = 47.4 bits (111), Expect = 3e-04
 Identities = 32/110 (29%), Positives = 51/110 (46%)

Query: 3976 PEFKDKLLSAERAVTGYKDPYSGKLISLFQAMKKGLILKDHGIRLLEAQIATGGIIDPEE 4035
            P F   L      + G  D  +    S+  A+ K ++    G +LLEAQ ATGGI+D   
Sbjct: 1814 PSFSLGLGDDSFPIAGIYDTTTDNKCSIKTAVAKNMLDPITGQKLLEAQAATGGIVDLLS 1873

Query: 4036 SHRLPVEVAYKRGLFDEEMNEILTDPSDDTKGFFDPNTEENLTYLQLMER 4085
              R  V  A +RGL +    + L +      G  DP T++ L+  + +++
Sbjct: 1874 RERYSVHKAMERGLIENTSTQRLLNAQKAFTGIEDPVTKKRLSVGEAVQK 1923


>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
           [Homo sapiens]
          Length = 2564

 Score =  307 bits (787), Expect = 1e-82
 Identities = 244/811 (30%), Positives = 381/811 (46%), Gaps = 79/811 (9%)

Query: 9   NEISSLKDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR 68
           + I +L DER+ VQKKTFTKWVN HL +   HI DLY DLRDG  L  LLEVLSG+ LPR
Sbjct: 50  SRIKALADEREAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPR 109

Query: 69  E-KGRMRFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDI 127
             +GRMR H L+NV  AL +L+ ++V L N+ + DI DGN +LTLGL+WTIIL FQI  I
Sbjct: 110 PTRGRMRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQVI 169

Query: 128 QVSGQS--EDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPLLIDM 185
           ++  +   E  +AK+ LLLW Q    GY  +   NFT+SWRDG  FNA+IHRH+P L+D 
Sbjct: 170 KIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLVDF 229

Query: 186 NKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLYDAMPRVPD 245
           +K+ +     NL +AF  AE+ LG+ RLLDPEDV++  PDEKSIITYV S Y    ++  
Sbjct: 230 SKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSFYHYFSKMKA 289

Query: 246 VQ-DGVRAN-------ELQLRWQEYRELVLLLLQWMRHHTAAFEERRFPSSFEEIEILWS 297
           +  +G R         E+    + Y EL   LL W+         ++F +S   ++    
Sbjct: 290 LAVEGKRIGKVLDQVLEVGKIIERYEELAAELLAWIHRTVGLISNQKFANSLSGVQQQLQ 349

Query: 298 QFLKFKEMELPAKEADKNRSKGIYQSLEGAVQA--GQLKVP-PGYHPLDVEKEWGKLHVA 354
            F  +  +E P K  +K   + +  S++  ++A   +L VP  G    D++K WG+L  A
Sbjct: 350 AFTAYCTLEKPVKFQEKGNLEVLLFSIQSKLRACNRRLFVPREGCGIWDIDKAWGELEKA 409

Query: 355 ILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSD---VRLLAAGKVPQ 411
             ERE  LR+E  R E L+ +  +   +  + E  LN+   L+  D     L A     +
Sbjct: 410 EHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAVEAAMK 469

Query: 412 RAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIRTEYNLRLK 471
           +   +E D+   +  ++ +    Q L         + Y  + R+  +  ++  ++ L L 
Sbjct: 470 KHEAIEADIAAYEERVQGVAELAQAL-------AAEGYYDIRRVAAQRDSVLRQWAL-LT 521

Query: 472 AGVAAPATQVAQ-VTLQSVQRRPELEDSTLRYLQDLLAWVEENQHRVDGAEWGVDLPSVE 530
             V A  T++ Q + LQ V +        + Y+ D   W+EE Q ++   E G  L   +
Sbjct: 522 GLVGARRTRLEQNLALQKVFQE-------MVYMVD---WMEEMQAQLLSRECGQHLVEAD 571

Query: 531 AQLGSHRGLHQSIEEFRAKIERARSD-------------EGQLSPATRGAYRDCLGRLDL 577
             L  H  L   I     ++E   +              + Q+          CL  L  
Sbjct: 572 DLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQE 631

Query: 578 QYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKEE--------------EEVGFDWS 623
           Q A+     +A L +  SL + +    +   W  +KE                  G    
Sbjct: 632 QAAR----RRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGG 687

Query: 624 DRNTNMTAK-KESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESFQ------- 675
             + + TA+    +  L  EL  +   +++    G+ L+       P  ++         
Sbjct: 688 AHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAER 747

Query: 676 -AALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSAT 734
            A+ + +W  + +     E  L+E  A  QF +D+   +G L  L++A R   + D    
Sbjct: 748 AASARRRWQRLEEAAARRERRLQEARALHQFGADL---DGLLDWLRDAYRLAAAGDFGHD 804

Query: 735 VTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 765
                 L +  +    ++  ++G +SGL ++
Sbjct: 805 EASSRRLARQHRALTGEVEAHRGPVSGLRRQ 835



 Score =  122 bits (306), Expect = 8e-27
 Identities = 308/1442 (21%), Positives = 558/1442 (38%), Gaps = 162/1442 (11%)

Query: 1081 EVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGER 1140
            E++   +E++     V   + E+   +A +++ R   E+      AL+  L G +   + 
Sbjct: 974  ELVEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQA 1033

Query: 1141 LQQRHG----ERDVEVERWRERVAQLLE-------RWQAVLAQTDVRQRELEQLGRQLRY 1189
            L+ R      E  +  ER+  + A+L +        W A+ +        +   GR  R+
Sbjct: 1034 LEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRF 1093

Query: 1190 YRESADPLGAWLQDARRRQEQIQAM--PLADSQAVREQLRQEQALLEEIERHGEKVEECQ 1247
              +    L A+L    R QE       PL +S      L +  ALL    RH    EE  
Sbjct: 1094 LHD----LDAFLDWLVRAQEAAGGSEGPLPNS------LEEADALLA---RHAALKEEVD 1140

Query: 1248 RFAKQYINAIKDYELQLVTYKAQLEP-VASPAKKPKVQSG-----------SESVIQEYV 1295
            +  + Y   +   E  L    A+L P +A     P ++ G            E+++Q ++
Sbjct: 1141 QREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHI 1200

Query: 1296 D---LRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ 1352
                LR     L  L +Q +      L    E     E+   + R+ L  +E + +K + 
Sbjct: 1201 YQLFLRDLRQALVVLRNQEMALSGAELPGTVES---VEEALKQHRDFLTTMELSQQKMQV 1257

Query: 1353 LAEAHAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQ--QKRSIQEELQQ-LRQSSEA 1409
              +A      Q     ++ Q+ +   + + +E  + AQQ  QK   Q ELQ  LR   E 
Sbjct: 1258 AVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHEL 1317

Query: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
            +     +   A + +R   E+  ++ +  L     +      EL   +   E+ E + +Q
Sbjct: 1318 DGWIHEKMLMARDGTR---EDNHKLHKRWL-----RHQAFMAELAQNKEWLEKIEREGQQ 1369

Query: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1529
              +E   L   V+ +    RQ   EL S  +A+A    E  +A Q ++       E +++
Sbjct: 1370 LMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQLVQSFA----ELDKK 1425

Query: 1530 LRQAEVERARQVQVALETAQRSAE-AELQSKRASFAEKTAQLERSLQEEHVAVAQLREEA 1588
            L   E +        L+      + A + S+        +Q+E   +E     AQ     
Sbjct: 1426 LLHMESQ--------LQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP 1477

Query: 1589 ERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAE 1648
               A ++   ER     ER L R      E  RL L ++E+ Q       E    +E   
Sbjct: 1478 LEPASKELVGERQNAVGER-LVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLP 1536

Query: 1649 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1708
               +       QAV+Q     Q L ++ Q      ++ L     L  LR+   + E  R+
Sbjct: 1537 LAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSP--EAEAVRR 1594

Query: 1709 LLEEELARLQREAAAATQKRQELEA---------ELAKVRA---EMEVLLASKARAEEES 1756
             LE+  +       AA +++Q L+A         ++A+V A   E E+L+ S+ + ++E 
Sbjct: 1595 GLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDE- 1653

Query: 1757 RSTSEKSKQRLEAEAG--RFRE-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVL 1813
            +ST +  K+ L+ E G   + E +A+ + + RAL E          E  +R++++ +R+ 
Sbjct: 1654 QSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPD----SEQISRRQSQVDRLY 1709

Query: 1814 AEKLAAIGEATRLKTEAEIALKEKEAENERLRR-LAEDEAFQRRRLEEQAAQHKADIEER 1872
               L  +GE  R+  E +  L +   +   L   +AE E         Q  +H + ++E+
Sbjct: 1710 VA-LKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEK 1768

Query: 1873 LAQLRKASDSELERQKGLV-EDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRS 1931
                     SE   + G+   + L    Q+ +E++    +   AAA  AE +  L    +
Sbjct: 1769 F--------SEFASETGMAGRERLAAVNQMVDELIECGHT---AAATMAEWKDGLNEAWA 1817

Query: 1932 NAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVER 1991
                     E  EL   R + LAA  E  +  ++ R  +    E+     R     E   
Sbjct: 1818 ---------ELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRP 1868

Query: 1992 LKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQ 2051
              + ++   R  E   Q    Q++  QE A +        HA A+  +EQE+ Q  ++  
Sbjct: 1869 SASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQGWKELL 1928

Query: 2052 SVLDQLRGEAEAARRAAEEAEEAR--------VQAEREAAQSRRQVEEAERL---KQSAE 2100
            S  +  R    +   A     + R        + ++  AA   R V   E L    Q  +
Sbjct: 1929 SACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEVLMNYHQGLK 1988

Query: 2101 EQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL----RQKQAADAEMEKHKKFAEQTL 2156
             + +AR       ++L +      +  A   QA L     +K+    + ++H ++ +Q L
Sbjct: 1989 TELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQML 2048

Query: 2157 R-----QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSV 2211
                  Q+A V     T +  L ++    + +DE  Q ++    EA R+ +   EE FS 
Sbjct: 2049 EVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRH--EAFRKAAAAWEERFSS 2106

Query: 2212 RVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271
              ++  + K+KA    +    +L      ++F  +  E             +AA+ A  L
Sbjct: 2107 LRRLTTIEKIKAEQSKQPPTPLL-----GRKFFGDPTE-------------LAAKAAPLL 2148

Query: 2272 RQLA-EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQ 2330
            R    E  L      A   L  +++      R + + E LQ + +   E   R++     
Sbjct: 2149 RPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPAALP 2208

Query: 2331 MAQQLAEETQGFQRTLEAERQR--QLEMSAEAERL-KLRVAEMSRAQARAEEDAQRFRKQ 2387
             A + A ET       E  R R  + E +  AE L + R  E   +  ++EE A+R R +
Sbjct: 2209 AAPEDAAETPATPAAAEQVRPRPERQESADRAEELPRRRRPERQESVDQSEEAARRRRPE 2268

Query: 2388 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLL 2447
             +E  E     E A    +   + +E +R++ +   ER   +  E+    + ++ +A L 
Sbjct: 2269 RQESAEH----EAAHSLTLGRYEQMERRRERRERRLERQESSEQEMPIRGDLVKGKATLA 2324

Query: 2448 QL 2449
             +
Sbjct: 2325 DI 2326



 Score =  122 bits (305), Expect = 1e-26
 Identities = 384/1779 (21%), Positives = 669/1779 (37%), Gaps = 230/1779 (12%)

Query: 994  ARECAQRIAEQQKA-------QAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLR---- 1042
            +REC Q + E           + ++    + V  L+A A +   L    P  P +     
Sbjct: 560  SRECGQHLVEADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRV 619

Query: 1043 SELELTLGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPE 1102
            + +   L +L++  +     LE  +++  +++  + AE   R  E  L+ A    A    
Sbjct: 620  NHVHGCLAELQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAA 679

Query: 1103 LEATKA-------SLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGE-----RDV 1150
              A  A       S  +L AQ +  Q      R  L+ A   GE L    G        V
Sbjct: 680  GAAGTAGGAHDLSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTV 739

Query: 1151 EVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQ 1210
             +    ER A    RWQ +      R+R L++  R L  +    D L  WL+DA R    
Sbjct: 740  HLVGLAERAASARRRWQRLEEAAARRERRLQE-ARALHQFGADLDGLLDWLRDAYRLAAA 798

Query: 1211 IQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQ 1270
                   D  + R   RQ +AL  E+E H   V   +R                     Q
Sbjct: 799  GDFG--HDEASSRRLARQHRALTGEVEAHRGPVSGLRR---------------------Q 835

Query: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE----EE 1326
            L  +   +    +    +  + E   L    +E+  L  Q+++      R   E    E 
Sbjct: 836  LATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACEL 895

Query: 1327 RLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKELQQRMQEEVVRREEAA 1386
             + E+++     R+ +    +E  +   E+  Q          ++   +QE V    E  
Sbjct: 896  WIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELV----EGG 951

Query: 1387 VDAQQQKRSIQEEL-----------QQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVV 1435
              +  + RS Q+ L           +Q ++   A +  +    E AE     +  ++R  
Sbjct: 952  HPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVLEVAE-----VRAQVREK 1006

Query: 1436 RLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEVEL 1495
            R  +E+  R  G  +  L  L A  +  E ++    EEA  L  +   ++ R  Q   EL
Sbjct: 1007 RRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEEL 1066

Query: 1496 ASRVKAEAEAAREKQRALQALEELR-------------LQAEEA--------ERRLRQAE 1534
             +   A A AA+    A+ A   L+             ++A+EA           L +A+
Sbjct: 1067 GAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEAD 1126

Query: 1535 VERARQVQVALETAQRSAEAE--LQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRA 1592
               AR   +  E  QR  +    + +  A  A   A+L   L     A+ +     E   
Sbjct: 1127 ALLARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGL-----ALDEWLPHLELGW 1181

Query: 1593 QQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAE-KQKEEAEREA 1651
             +      AR EA  +   +QL     LR   QA  V + + +A + AE     E+  EA
Sbjct: 1182 HKLLGLWEARREALVQAHIYQL----FLRDLRQALVVLRNQEMALSGAELPGTVESVEEA 1237

Query: 1652 RRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE 1711
                K     +   EL++Q+++   Q AEG              LR     GEQ ++ + 
Sbjct: 1238 L---KQHRDFLTTMELSQQKMQVAVQAAEGL-------------LRQGNIYGEQAQEAVT 1281

Query: 1712 EELARLQREAAAATQKRQELEAEL-----AKVRAEMEVLLASK-ARAEEESRSTSEKSKQ 1765
              L + Q     A Q  Q+L  +L      +   E++  +  K   A + +R  + K  +
Sbjct: 1282 RLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHK 1341

Query: 1766 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATR 1825
            R         ELA+    L  +  E ++  Q   E AA  R +   +  +  A +   T+
Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEI-RQCWAELESTTQ 1400

Query: 1826 LKTEAEIALKEKEAENERLRRLAE-DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSEL 1884
             K      L E    ++ ++  AE D+       + Q      D+    +QL+K     L
Sbjct: 1401 AKAR---QLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKK-----L 1452

Query: 1885 ERQKGLVEDTLRQRRQVEEEILAL---KASFE-----KAAAGKAELELELGRIRSNAEDT 1936
            +  +  VE+  R+  +++ +  AL    AS E     + A G+  + L L  ++      
Sbjct: 1453 QSMESQVEEWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRL-LEPLQERRRLL 1511

Query: 1937 LRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAARQRKAALEEVERLKAKV 1996
            L SKE  ++      +LA  +ER     +      L A ++  ++ +    E++    ++
Sbjct: 1512 LASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRL 1571

Query: 1997 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHA---FAVQQKEQELQQTLQQEQSV 2053
            EE   + ERA   ++ +   A EA ++ L+  + A A    A ++++Q L    Q EQ  
Sbjct: 1572 EE---VLERAGALASLRSPEA-EAVRRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYY 1627

Query: 2054 LDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQ-AQARAQAQAA 2112
             D    EA    +      E + + E+   Q  ++  + E+  ++ EE  AQ   Q +A 
Sbjct: 1628 FDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRAL 1687

Query: 2113 AEKLRKEAEQEAARRAQAEQAALRQKQAADAEME--KHKKFAEQTLRQKAQV-----EQE 2165
             E    ++EQ + R++Q ++  +  K+  +      + + +  Q  RQ +++     E+E
Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE 1747

Query: 2166 LTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQR----SQVEEELF----SVRVQMEE 2217
            +     +L +     ++L E+     +E   A R+R    +Q+ +EL     +    M E
Sbjct: 1748 VVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAE 1807

Query: 2218 LSKLKARIEAE------NRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARL 2271
                     AE       RA +L       +F  +  E   Q+ E+  RL        RL
Sbjct: 1808 WKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL-------PRL 1860

Query: 2272 RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2331
                E      R  A  M +  ++A +   +L   +++ Q Q+  AQ +     E  E +
Sbjct: 1861 TTPPE-----PRPSASSM-QRTLRAFEHDLQLLV-SQVRQLQEGAAQLRTVYAGEHAEAI 1913

Query: 2332 AQQLAEETQGFQRTLEAERQRQLEMSAEAERLKLR------VAEMSRAQARAEEDAQRFR 2385
            A +  E  QG++  L A    +L +S+ A+ L+        ++ M    ++     +   
Sbjct: 1914 ASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAADKPRD 1973

Query: 2386 KQAEEIGEKLH---RTEL-ATQEKVTLVQTL-------------EIQRQQSDHDAERLRE 2428
              + E+    H   +TEL A   ++T  Q L             EIQ  Q D    R  E
Sbjct: 1974 VSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQ-AQLDKLGTRKEE 2032

Query: 2429 AIAELEREKEKLQQEAKLLQLKSE----EMQTVQQEQLLQETQALQQSFLSEKDSLLQRE 2484
               + +R  E LQQ  ++ Q   E    +     QE LLQ  +    S + E + L++R 
Sbjct: 2033 VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSREL--GSSVDEVEQLIRRH 2090

Query: 2485 RFIEQEKAKLEQLFQD--EVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAEE 2542
                +  A  E+ F     +   ++++ EQ +Q       R+      E A +       
Sbjct: 2091 EAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRP 2150

Query: 2543 -GVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLE-EQHRAALAHSEEVTAS-QVA 2599
             G  R  E L      RR  + L AE   R+    Q L+ E+ +  +    E+    + A
Sbjct: 2151 GGYERGLEPL-----ARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRLPEIPGRVEPA 2205

Query: 2600 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQE 2638
            A    P   DA + PA  A  E       R+ SA R +E
Sbjct: 2206 ALPAAP--EDAAETPATPAAAEQVRPRPERQESADRAEE 2242



 Score =  102 bits (255), Expect = 7e-21
 Identities = 355/1724 (20%), Positives = 644/1724 (37%), Gaps = 254/1724 (14%)

Query: 1102 ELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQ 1161
            EL A +A++KK     EA +    A  + ++G  E+ + L     E   ++ R   +   
Sbjct: 460  ELPAVEAAMKK----HEAIEADIAAYEERVQGVAELAQALA---AEGYYDIRRVAAQRDS 512

Query: 1162 LLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQA 1221
            +L +W  +      R+  LEQ     + ++E    +  W+++    Q Q+ +        
Sbjct: 513  VLRQWALLTGLVGARRTRLEQNLALQKVFQEMVYMVD-WMEEM---QAQLLSRECGQHLV 568

Query: 1222 VREQLRQEQALLE-EIERHGEKVEECQRFAKQY--INAIKDYELQLVTYK--------AQ 1270
              + L Q+  LLE +I    E+VE     A ++  +   +  + Q++  +        A+
Sbjct: 569  EADDLLQKHGLLEGDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAE 628

Query: 1271 LEPVASPAKKPKVQSGSE-SVIQEYVDLRTHYSELTTL-----------------TSQYI 1312
            L+  A+  +     S S  +++QE  +  +   +   L                 T+   
Sbjct: 629  LQEQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGA 688

Query: 1313 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEA-----------HAQAK 1361
              +S T R + + + L    + E   R A ++ AL    +L  A           H    
Sbjct: 689  HDLSSTARLLAQHKIL----QGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGL 744

Query: 1362 AQAEREAKELQQRMQEEVVRREEAAVDAQ---QQKRSIQEELQQLRQSSEAEIQAKARQA 1418
            A+    A+   QR++E   RRE    +A+   Q    +   L  LR +            
Sbjct: 745  AERAASARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHD 804

Query: 1419 EAAERSRLR----IEEEIRVVRLQLEATERQ---RGGAEGE---LQALRARAEEAEAQKR 1468
            EA+ R   R    +  E+   R  +    RQ    GGA G    + AL+ R  EAE    
Sbjct: 805  EASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFA 864

Query: 1469 QAQEEAERLRRQVQDESQRKRQ-AEVELASRVKAEAEAAREKQRALQALEELRL------ 1521
            +  E A   R+ ++D     R   EV        E E      R   +L+++ +      
Sbjct: 865  EVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFE 924

Query: 1522 QAEEAERRLRQAEVERARQVQVALETAQ------RSAEAELQSKRASFAEKTAQLERSLQ 1575
              ++    L    ++    VQ  +E         RS +  L S+     E   Q +  + 
Sbjct: 925  SLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMS 984

Query: 1576 EEHVAVAQLREEAERRAQQQAEAERAREEAERE--LERWQLKANEALRLRLQAEEVAQQK 1633
               +    + E AE RAQ + E  RA E A R     +W+L   EA    LQA E  Q  
Sbjct: 985  AVLLVENHVLEVAEVRAQVR-EKRRAVESAPRAGGALQWRLSGLEA---ALQALEPRQAA 1040

Query: 1634 SLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1693
             L +A    ++  A+  AR    AEE       LA         +A     QR   + + 
Sbjct: 1041 LLEEAALLAERFPAQ-AARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDA 1099

Query: 1694 I---RLRAETEQGEQQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLA 1747
                 +RA+   G  +  L   LEE  A L R AA   +  Q  E + A++ A  E LLA
Sbjct: 1100 FLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEEVDQR-EEDYARIVAASEALLA 1158

Query: 1748 SKARAEEESRSTSE----------------KSKQRLEAEAG----------------RFR 1775
            +         +  E                ++++    +A                 R +
Sbjct: 1159 ADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQ 1218

Query: 1776 ELAEEAARLRAL---AEEAKRQRQ--LAEEDAARQRAEAERVLAEKLAAIGEA-TRLKTE 1829
            E+A   A L       EEA +Q +  L   + ++Q+ +     AE L   G        E
Sbjct: 1219 EMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQE 1278

Query: 1830 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQ-HKAD--IEERLAQLR--------- 1877
            A   L EK  EN+   +    +   +  L+      H+ D  I E++   R         
Sbjct: 1279 AVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHK 1338

Query: 1878 --------KASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRI 1929
                    +A  +EL + K  +E   R+ +Q+ +E   L AS  K          +LG I
Sbjct: 1339 LHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRK----------KLGEI 1388

Query: 1930 R---SNAEDTLRSKEQAELEAARQRQLA---AEEERRRREAEERVQKSLAAEEEAARQRK 1983
            R   +  E T ++K +   EA++  QL    AE +++    E ++Q      + A     
Sbjct: 1389 RQCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLAT--VN 1446

Query: 1984 AALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQEL 2043
            + L++++ ++++VEE  R      +  A+   L  E A K L  E +    AV ++   L
Sbjct: 1447 SQLKKLQSMESQVEEWYR---EVGELQAQTAALPLEPASKELVGERQN---AVGERLVRL 1500

Query: 2044 QQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
             + LQ+ + +L   +   + A    +E   A VQ     A    +    + ++Q  ++  
Sbjct: 1501 LEPLQERRRLLLASKELHQVAHDLDDEL--AWVQERLPLAMQTERGNGLQAVQQHIKKNQ 1558

Query: 2104 QARAQAQAAAEKLRKEAEQEAA------RRAQAEQAALRQKQAADAEMEKHKKFAEQTLR 2157
              R + QA   +L +  E+  A        A+A +  L Q Q+A A + +  +  +Q L 
Sbjct: 1559 GLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLD 1618

Query: 2158 QKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEATEAARQRSQVEEELFSVRVQMEE 2217
               QVEQ         +  + +  L ++EL  +  +  +  +   Q+ ++   +   +E 
Sbjct: 1619 AAFQVEQ------YYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVEN 1672

Query: 2218 LSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE 2277
              +  A++  + RAL+             ++E++ +   +  RL VA +E    R++A E
Sbjct: 1673 YEESIAQLSRQCRALL--------EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALE 1724

Query: 2278 DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ--EQARRLQEDKEQMA--- 2332
                     +  L +  + V E     AE E++    EL Q  E    LQE   + A   
Sbjct: 1725 Q--------QYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET 1776

Query: 2333 -----QQLAEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEM-----SRAQARAE---- 2378
                 ++LA   Q     +E        M+   + L    AE+     +RAQ  A     
Sbjct: 1777 GMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASREL 1836

Query: 2379 ----EDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELE 2434
                 DA+  + Q EE   +L R     + + +   +++   +  +HD + L   + +L+
Sbjct: 1837 HKFFSDARELQGQIEEKRRRLPRLTTPPEPRPS-ASSMQRTLRAFEHDLQLLVSQVRQLQ 1895

Query: 2435 REKEKLQ-------------QEAKLLQLKSEEMQTVQQEQLLQETQALQQSFLSEKDSLL 2481
                +L+             +E ++LQ   E +   +  +L   + A    F S+   LL
Sbjct: 1896 EGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLL 1955

Query: 2482 QRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHEAE 2541
                 I  +    ++    +V+  + L    Q  + ++E     L    E  R       
Sbjct: 1956 SWMDGIASQIGAADK--PRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKS 2013

Query: 2542 EGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVAAT 2601
                  Q +L +L  ++ +  E      + L++ L++ +    A +A +       +  +
Sbjct: 2014 AMADEIQAQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQS 2073

Query: 2602 KTLPNGRDALDG--------PAAEAEPEHSFDGLRRKVSAQRLQ 2637
            + L +  D ++           A A  E  F  LRR  + ++++
Sbjct: 2074 RELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIK 2117



 Score = 99.8 bits (247), Expect = 6e-20
 Identities = 341/1654 (20%), Positives = 617/1654 (37%), Gaps = 263/1654 (15%)

Query: 503  LQDLLAWVEENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEFRAKIERARSDEGQLSP 562
            L  LL W+ +        ++G D  S       HR L   +E  R  +   R     L  
Sbjct: 782  LDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRALTGEVEAHRGPVSGLRRQLATLGG 841

Query: 563  ATRG-----AYRDCLGRLDLQYAKLLNSSKAR---LRSLESLHSFVAAATKELMWLNEKE 614
            A+       A +  +   +  +A++   +  R   LR   +++          +W+ EKE
Sbjct: 842  ASGAGPLVVALQVRVVEAEQLFAEVTEVAALRRQWLRDALAVYRMFGEVHACELWIGEKE 901

Query: 615  EEEVGFDWSDRNTNMTAKKESYSALMRELELKEKKIKELQNAGDRLLREDHPARPTVESF 674
            +  +     D   ++   +  + +L +E+     ++ ++ +    L+   HP+   V S 
Sbjct: 902  QWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLMGRVLDVNHTVQELVEGGHPSSDEVRSC 961

Query: 675  QAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEALRRKYSCDRSA- 733
            Q  L ++W+ +++L   +E   +E +A     + V E      +++E  R   S  R+  
Sbjct: 962  QDHLNSRWNRIVEL---VEQRKEEMSAVLLVENHVLEVAEVRAQVREKRRAVESAPRAGG 1018

Query: 734  ----TVTRLEDLLQDAQDEKEQLNEYKGHLS----------------------GLAKRAK 767
                 ++ LE  LQ  +  +  L E    L+                       LA  A+
Sbjct: 1019 ALQWRLSGLEAALQALEPRQAALLEEAALLAERFPAQAARLHQGAEELGAEWGALASAAQ 1078

Query: 768  AVVQ----------------------LKPRHPAHPMRGRLP--------LLAVCDYKQVE 797
            A  +                      ++ +  A    G LP        LLA     + E
Sbjct: 1079 ACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSEGPLPNSLEEADALLARHAALKEE 1138

Query: 798  VTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQAL 857
            V   + D  ++V  ++     +L++ G+E            P     E +  LE     L
Sbjct: 1139 VDQREEDYARIVAASE----ALLAADGAELG----------PGLALDEWLPHLELGWHKL 1184

Query: 858  VTLWHQLHVDMKSLLAWQSLRRDVQ----LIRSWSLATFRTLKP----------EEQRQA 903
            + LW      +     +Q   RD++    ++R+  +A      P          ++ R  
Sbjct: 1185 LGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEEALKQHRDF 1244

Query: 904  LHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRC 963
            L ++EL  Q      Q A G   +  +  E+         + + + LE+  + + R Q+ 
Sbjct: 1245 LTTMELSQQKMQVAVQAAEGLLRQGNIYGEQA-------QEAVTRLLEKNQENQLRAQQW 1297

Query: 964  ISELKDIRLQLEACETRTVHRL------RLPLDKEPARE----CAQRIAEQQKAQAEVEG 1013
            + +L D +L+L+    R  H L      ++ + ++  RE      +R    Q   AE+  
Sbjct: 1298 MQKLHD-QLELQHF-LRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQ 1355

Query: 1014 LGKGVARLSAEAEKVL-ALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLV 1072
              + + ++  E ++++   PE + +      E+     +LE      A  L +      +
Sbjct: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415

Query: 1073 IRGTQGAEEVLRAHEEQLKEAQ------AVPATLPELEATKASLKKLRAQAEAQQPTFDA 1126
            ++     ++ L   E QL++         V + L +L++ ++ +++   +    Q    A
Sbjct: 1416 VQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAA 1475

Query: 1127 LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQTDVRQRELEQLGRQ 1186
            L  E    + VGER Q   GER V +      +  L ER + +LA      +EL Q+   
Sbjct: 1476 LPLEPASKELVGER-QNAVGERLVRL------LEPLQERRRLLLA-----SKELHQVAHD 1523

Query: 1187 LRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEEC 1246
            L       D   AW+Q+  R    +Q       QAV++ +++ Q L  EI+ HG ++EE 
Sbjct: 1524 L-------DDELAWVQE--RLPLAMQTERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEV 1574

Query: 1247 QRFAKQYINAIKDYELQLVTYKAQLEPVASP-AKKPKVQSGSESVIQEYVDLRTHYSELT 1305
               A   + +++  E + V  +  LE + S  A   +     + V+     +  +Y ++ 
Sbjct: 1575 LERAGA-LASLRSPEAEAV--RRGLEQLQSAWAGLREAAERRQQVLDAAFQVEQYYFDVA 1631

Query: 1306 TLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQA 1364
             + +       + L  M E++   EQ   +  ++  ++E  +E  +  +A+   Q +A  
Sbjct: 1632 EVEAW---LGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALL 1688

Query: 1365 EREAKELQQ--RMQEEVVRREEAAVDAQQQKRSIQEE---LQQL-RQSSEAEIQAKARQA 1418
            E    + +Q  R Q +V R   A  +  +++R   E+   L QL RQ SE E     ++ 
Sbjct: 1689 EMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEV 1748

Query: 1419 EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGE-LQALRARAEEAEAQKRQAQEEAERL 1477
             A      +  E + V++ +      + G A  E L A+    +E      +    A   
Sbjct: 1749 VAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDEL----IECGHTAAAT 1804

Query: 1478 RRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRL-RQAEVE 1536
              + +D         +EL         A+RE  +      EL+ Q EE  RRL R     
Sbjct: 1805 MAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPP 1864

Query: 1537 RARQVQVALETAQRSAEAELQ---SKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
              R    +++   R+ E +LQ   S+     E  AQL      EH      RE  +   Q
Sbjct: 1865 EPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE--QEVLQ 1922

Query: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEE-------VAQQKSLAQAEAEKQKEE 1646
               E   A E+A   +        +ALR   Q  +       +A Q   A    +    E
Sbjct: 1923 GWKELLSACEDARLHVS----STADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVE 1978

Query: 1647 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAE--TEQGE 1704
                  +  K E +A        QEL +   L +      + A+ + +  R E  +E+ +
Sbjct: 1979 VLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEVSEKWD 2038

Query: 1705 QQRQLLEE--ELARLQREAAAA----TQKRQELEA-ELAKVRAEMEVLLA-----SKARA 1752
            +  + L++  E+ +  +EA  A    T +   L++ EL     E+E L+       KA A
Sbjct: 2039 RHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAFRKAAA 2098

Query: 1753 EEESRSTS------------EKSKQRLEAEAGRF-----RELAEEAARL-------RALA 1788
              E R +S            E+SKQ      GR       ELA +AA L       R L 
Sbjct: 2099 AWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGRKFFGDPTELAAKAAPLLRPGGYERGLE 2158

Query: 1789 EEAKRQRQLAEEDA------ARQRAEAERVLAEKLAAIGEAT-RLKTEAEIALKEKEAEN 1841
              A+R       +        RQ  + ER L  ++  + E   R++  A  A  E  AE 
Sbjct: 2159 PLARRASDTLSAEVRTRVGYVRQELKPER-LQPRIDRLPEIPGRVEPAALPAAPEDAAET 2217

Query: 1842 ERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQV 1901
                  AE    +  R      Q  AD  E L + R+    E   Q    E+  R+RR  
Sbjct: 2218 PATPAAAEQVRPRPER------QESADRAEELPRRRRPERQESVDQS---EEAARRRRPE 2268

Query: 1902 EEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRR 1961
             +E          +A  +A   L LGR               ++E  R+R+       RR
Sbjct: 2269 RQE----------SAEHEAAHSLTLGRYE-------------QMERRRERR------ERR 2299

Query: 1962 REAEERVQKSLAAEEEAARQRKAALEEVERLKAK 1995
             E +E  ++ +    +  + +    + VE+L+ K
Sbjct: 2300 LERQESSEQEMPIRGDLVKGKATLADIVEQLQEK 2333



 Score = 85.5 bits (210), Expect = 1e-15
 Identities = 275/1239 (22%), Positives = 471/1239 (38%), Gaps = 168/1239 (13%)

Query: 1001 IAEQQKAQAEVEGLGKGVARLSAEAEKVLALPE----PSPAAPTLRSELELTLGKLEQVR 1056
            +A     + EV+   +  AR+ A +E +LA       P  A       LEL   KL  + 
Sbjct: 1129 LARHAALKEEVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLW 1188

Query: 1057 SLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQ 1116
                  L +     L +R  + A  VLR  E  L  A+ +P T+  +E      +     
Sbjct: 1189 EARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAE-LPGTVESVEEALKQHRDFLTT 1247

Query: 1117 AEAQQPTFDALRDELRG-----------AQEVGERLQQRHGERDVEVERWRERVAQLLER 1165
             E  Q           G           AQE   RL +++ E  +  ++W +++   LE 
Sbjct: 1248 MELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLEL 1307

Query: 1166 ------------W---QAVLAQTDVRQRELEQLGRQLRYYRESADPLG--AWLQDARRRQ 1208
                        W   + ++A+   R+   +   R LR+    A+      WL+   R  
Sbjct: 1308 QHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREG 1367

Query: 1209 EQIQAMPLADSQAVREQLRQEQALLEEIER----HGEKVEECQRFAKQYINAIKDYELQL 1264
            +Q+       + +VR++L + +    E+E        ++ E  + A Q + +  + + +L
Sbjct: 1368 QQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASK-ADQLVQSFAELDKKL 1426

Query: 1265 VTYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEE 1324
            +  ++QL+ V        V S  + +      +   Y E+  L +Q      E   +   
Sbjct: 1427 LHMESQLQDVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALPLEPASK--- 1483

Query: 1325 EERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVR 1381
             E + E+Q A   ERL  +   L+++R+L  A  +    A     EL   Q+R+   +  
Sbjct: 1484 -ELVGERQNAVG-ERLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQT 1541

Query: 1382 REEAAVDAQQQ--------KRSIQEE---LQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1430
                 + A QQ        +R IQ     L+++ + + A    ++ +AEA  R   +++ 
Sbjct: 1542 ERGNGLQAVQQHIKKNQGLRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQS 1601

Query: 1431 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490
                +R   EA ER++   +   Q  +   + AE +    ++E   +      + Q   Q
Sbjct: 1602 AWAGLR---EAAERRQQVLDAAFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ 1658

Query: 1491 A---EVELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALET 1547
                 ++L   V+   E+  +  R  +AL E+     E   R RQ++V+R   + VAL+ 
Sbjct: 1659 LLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQISR-RQSQVDR---LYVALKE 1714

Query: 1548 A--QRSAEAELQSKRASFAEKTAQLERSLQEEHVA------------VAQLREEAERRAQ 1593
               +R    E Q      + + ++LE  + E+ V             V+ L+E+    A 
Sbjct: 1715 LGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFAS 1774

Query: 1594 QQAEAERAREEAEREL---------------ERWQLKANEA---------LRLRLQAEEV 1629
            +   A R R  A  ++                 W+   NEA          R +L A   
Sbjct: 1775 ETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASR 1834

Query: 1630 AQQKSLAQA-EAEKQKEEAER---------EARRRGKAEEQAVRQRELAEQELEKQ-RQL 1678
               K  + A E + Q EE  R         E R    + ++ +R  E   Q L  Q RQL
Sbjct: 1835 ELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQL 1894

Query: 1679 AEGTAQQRLAAEQELIRLRAETEQGEQQ--RQLLEE-ELARLQREAAAATQKRQELEAEL 1735
             EG AQ R     E     A  EQ   Q  ++LL   E ARL     ++T       +++
Sbjct: 1895 QEGAAQLRTVYAGEHAEAIASREQEVLQGWKELLSACEDARLH---VSSTADALRFHSQV 1951

Query: 1736 AKVRAEMEVLLASKARAEEESRSTSEKS---------KQRLEAEAGRFRELAEEAARLRA 1786
              + + M+ + AS+  A ++ R  S            K  LEA         +E  R   
Sbjct: 1952 RDLLSWMDGI-ASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTT-CQELGRSLL 2009

Query: 1787 LAEEAKRQRQLAEEDAARQRAEAERVLAEK-------LAAIGEATRLKTEAEIALKEKEA 1839
            L + A      A+ D    R E    ++EK       L  + E  +   EA +A     A
Sbjct: 2010 LNKSAMADEIQAQLDKLGTRKEE---VSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTA 2066

Query: 1840 ENERL--RRLAE--DEAFQRRRLEEQAAQHKADIEERLAQLRKASDSE---LERQKGLVE 1892
            +   L  R L    DE  Q  R  E   +  A  EER + LR+ +  E    E+ K    
Sbjct: 2067 QEPLLQSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPT 2126

Query: 1893 DTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELEAARQRQ 1952
              L ++   +   LA KA+      G    E  L  +   A DTL ++ +  +   RQ +
Sbjct: 2127 PLLGRKFFGDPTELAAKAAPLLRPGG---YERGLEPLARRASDTLSAEVRTRVGYVRQ-E 2182

Query: 1953 LAAEEERRR----REAEERVQKSL--AAEEEAARQ--RKAALEEVERLKAKVEEARRLRE 2004
            L  E  + R     E   RV+ +   AA E+AA      AA E+V     + E A    +
Sbjct: 2183 LKPERLQPRIDRLPEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESA----D 2238

Query: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064
            RAE+   R+    QE+  +  +A  +      +  E E   +L   +    + R E    
Sbjct: 2239 RAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRER 2298

Query: 2065 RRAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQA 2103
            R   +E+ E  +    +  + +  +  A+ ++Q  E++A
Sbjct: 2299 RLERQESSEQEMPIRGDLVKGKATL--ADIVEQLQEKEA 2335



 Score = 81.6 bits (200), Expect = 2e-14
 Identities = 245/1111 (22%), Positives = 423/1111 (38%), Gaps = 161/1111 (14%)

Query: 841  QEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRSWSLATFRTLK--PE 898
            ++AQEAVTRL  ++Q       Q    +   L  Q   RD   +  W        +    
Sbjct: 1274 EQAQEAVTRLLEKNQENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTR 1333

Query: 899  EQRQALHSLELHYQAFL--------------RDSQDAGGFGPEDRLMAEREYGSCSHHYQ 944
            E    LH   L +QAF+              R+ Q      PE      ++ G      +
Sbjct: 1334 EDNHKLHKRWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLG----EIR 1389

Query: 945  QLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECA---QRI 1001
            Q    LE   Q ++R     S+   +       + + +H      D +P  + A    ++
Sbjct: 1390 QCWAELESTTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQL 1449

Query: 1002 AEQQKAQAEVEGLGKGVARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAI 1061
             + Q  +++VE   + V  L A+     ALP   PA+  L  E +  +G+   VR     
Sbjct: 1450 KKLQSMESQVEEWYREVGELQAQ---TAALP-LEPASKELVGERQNAVGE-RLVR----- 1499

Query: 1062 YLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQ-AVPATLPE-----LEATKASLKK--- 1112
             LE L+    ++  ++   +V    +++L   Q  +P  +       L+A +  +KK   
Sbjct: 1500 LLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIKKNQG 1559

Query: 1113 LRAQAEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQ 1172
            LR + +A  P            +EV ER       R  E E  R  + QL   W  +   
Sbjct: 1560 LRREIQAHGPRL----------EEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREA 1609

Query: 1173 TDVRQRELEQLGRQLRYYRESADPLGAWL--------QDARRRQEQIQAMPLAD------ 1218
             + RQ+ L+   +  +YY + A+ + AWL         + + + EQ     L        
Sbjct: 1610 AERRQQVLDAAFQVEQYYFDVAE-VEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQ 1668

Query: 1219 -----SQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINAIKDY-ELQLVTYKAQ-- 1270
                  +++ +  RQ +ALLE      E++   Q    +   A+K+  E + V  + Q  
Sbjct: 1669 GVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRLYVALKELGEERRVALEQQYW 1728

Query: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330
            L  ++    + +     + V+    +L   +  ++ L  ++ +F SET   M   ERLA 
Sbjct: 1729 LYQLSRQVSELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASET--GMAGRERLAA 1786

Query: 1331 -QQRAEERERLAEVEAA--LEKQRQLAEAHAQ------AKAQ---AERE-------AKEL 1371
              Q  +E        AA   E +  L EA A+       +AQ   A RE       A+EL
Sbjct: 1787 VNQMVDELIECGHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDAREL 1846

Query: 1372 QQRMQEEVVR---------REEAAVDAQQQKRSIQEELQ----QLRQSSEAEIQAKARQA 1418
            Q +++E+  R            +A   Q+  R+ + +LQ    Q+RQ  E   Q +   A
Sbjct: 1847 QGQIEEKRRRLPRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYA 1906

Query: 1419 -EAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERL 1477
             E AE    R +E ++  +  L A E  R        ALR       +Q R      + +
Sbjct: 1907 GEHAEAIASREQEVLQGWKELLSACEDARLHVSSTADALR-----FHSQVRDLLSWMDGI 1961

Query: 1478 RRQVQDESQRKRQAEVELASR----VKAEAEAAREKQRALQALEELRLQAEEAERRLRQA 1533
              Q+    + +  + VE+       +K E EA   +    Q L    L  + A     QA
Sbjct: 1962 ASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021

Query: 1534 EVERARQVQVALETAQRSAEAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQ 1593
            ++++           ++   +E   +   + ++  ++ +  QE  VA A L   A+    
Sbjct: 2022 QLDKL--------GTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWL--TAQEPLL 2071

Query: 1594 QQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQAEAEKQKEEAEREARR 1653
            Q  E   + +E E+ + R +     A     +   + +  ++ + +AE+ K+       R
Sbjct: 2072 QSRELGSSVDEVEQLIRRHEAFRKAAAAWEERFSSLRRLTTIEKIKAEQSKQPPTPLLGR 2131

Query: 1654 R--GKAEEQAVRQRELA-----EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQ 1706
            +  G   E A +   L      E+ LE   + A  T    +      +R   + E+ + +
Sbjct: 2132 KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPR 2191

Query: 1707 RQLLEEELARLQREA---------------AAATQKRQELEAELAKVRAEMEVLLASKAR 1751
               L E   R++  A               AAA Q R   E + +  RAE    L  + R
Sbjct: 2192 IDRLPEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPERQESADRAEE---LPRRRR 2248

Query: 1752 AE-EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALA--EEAKRQRQLAEEDAARQRAE 1808
             E +ES   SE++ +R   E  R      EAA    L   E+ +R+R+  E    RQ + 
Sbjct: 2249 PERQESVDQSEEAARRRRPE--RQESAEHEAAHSLTLGRYEQMERRRERRERRLERQESS 2306

Query: 1809 AERVLAEKLAAIGEATRLKTEAEIALKEKEA 1839
             + +        G+AT      +  L+EKEA
Sbjct: 2307 EQEMPIRGDLVKGKATLADIVEQ--LQEKEA 2335



 Score = 81.3 bits (199), Expect = 2e-14
 Identities = 312/1420 (21%), Positives = 544/1420 (38%), Gaps = 270/1420 (19%)

Query: 1494 ELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETA----Q 1549
            E A+R +AE EA+R     LQ LEE    A + ER L  A    A     A  TA     
Sbjct: 631  EQAARRRAELEASRSLWALLQELEEAESWARDKERLLEAAGGGGAAGAAGAAGTAGGAHD 690

Query: 1550 RSAEAELQSK----RASFAEKTAQLERSLQ--EEHVAVA--------------------- 1582
             S+ A L ++    +     + A L+++L+  EE VA                       
Sbjct: 691  LSSTARLLAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAAS 750

Query: 1583 -----QLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQ 1637
                 Q  EEA  R +++ +  RA  +   +L+       +A RL    +    + S  +
Sbjct: 751  ARRRWQRLEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRR 810

Query: 1638 AEAEKQKEEAEREARR---RGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1694
               + +    E EA R    G   + A          L    Q+    A+Q  A   E+ 
Sbjct: 811  LARQHRALTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAEVTEVA 870

Query: 1695 RLR-------------------AETEQGEQQRQLLE-------EELARLQREAAAATQKR 1728
             LR                    E   GE+++ LL        +++  +Q    +  Q+ 
Sbjct: 871  ALRRQWLRDALAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEM 930

Query: 1729 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR----LEAEAGRFRELAE----- 1779
              L   +  V   ++ L+     + +E RS  +    R    +E    R  E++      
Sbjct: 931  NSLMGRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVE 990

Query: 1780 ----EAARLRALAEEAKR------------QRQLAEEDAARQRAE-AERVLAEKLAAIGE 1822
                E A +RA   E +R            Q +L+  +AA Q  E  +  L E+ A + E
Sbjct: 991  NHVLEVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAE 1050

Query: 1823 -----ATRLKTEAE-------------IALKEKEAENERLRRLAED-EAFQRRRLEEQAA 1863
                 A RL   AE              A  E  A   RL+R   D +AF    +  Q A
Sbjct: 1051 RFPAQAARLHQGAEELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEA 1110

Query: 1864 QHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAEL- 1922
                  E  L    + +D+ L R   L E+ + QR +    I+A  AS    AA  AEL 
Sbjct: 1111 --AGGSEGPLPNSLEEADALLARHAALKEE-VDQREEDYARIVA--ASEALLAADGAELG 1165

Query: 1923 ----------ELELG--RIRSNAEDTLRSKEQAE-----LEAARQRQLAAEEERRRREAE 1965
                       LELG  ++    E    +  QA      L   RQ  +    +       
Sbjct: 1166 PGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGA 1225

Query: 1966 ERVQKSLAAEEEAARQRKAALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2025
            E +  ++ + EEA +Q +  L  +E  + K++ A +  E   ++     + AQEA  + L
Sbjct: 1226 E-LPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLL 1284

Query: 2026 QAEEKAHAFAVQQKEQELQQTLQQEQSVLD--QLRG--------EAEAARRAAEEAEEAR 2075
            +  ++ +    QQ  Q+L   L+ +  + D  +L G          +  R    +  +  
Sbjct: 1285 EKNQE-NQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTREDNHKLHKRW 1343

Query: 2076 VQAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2135
            ++ +   A+  +  E  E++++  ++  Q + +  A+  K   E  Q  A      QA  
Sbjct: 1344 LRHQAFMAELAQNKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKA 1403

Query: 2136 RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKNLLDEELQRLKAEAT 2195
            RQ   A          A+Q ++  A+++++L  +  QL++ D   +L     Q  K ++ 
Sbjct: 1404 RQLFEASK--------ADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSM 1455

Query: 2196 EAARQRSQVEEELFSVRVQMEELSKLKARIEAENRALILRDKDNTQRFLQEEAEKMKQVA 2255
            E     SQVEE    V     + + L   +E  ++ L+       Q  + E   ++ +  
Sbjct: 1456 E-----SQVEEWYREVGELQAQTAALP--LEPASKELV----GERQNAVGERLVRLLEPL 1504

Query: 2256 EEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2315
            +E  RL +A++E   L Q+A  DL  + A  ++ L   MQ  +    L+A  + +++ + 
Sbjct: 1505 QERRRLLLASKE---LHQVA-HDLDDELAWVQERLPLAMQ-TERGNGLQAVQQHIKKNQG 1559

Query: 2316 LAQE---QARRLQEDKEQ---MAQQLAEETQGFQRTLE------------AERQRQ-LEM 2356
            L +E      RL+E  E+   +A   + E +  +R LE            AER++Q L+ 
Sbjct: 1560 LRREIQAHGPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAWAGLREAAERRQQVLDA 1619

Query: 2357 SAEAERLKLRVAE------------MSRAQARAEEDAQRFRKQAEEIGEKLHRTE----- 2399
            + + E+    VAE            MS  + + E+   +  K+  ++ + +   E     
Sbjct: 1620 AFQVEQYYFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQ 1679

Query: 2400 LATQEKVTL----VQTLEIQRQQSDHDAERLREAIAEL-EREKEKLQQEAKLLQLK---S 2451
            L+ Q +  L      + +I R+QS  D  RL  A+ EL E  +  L+Q+  L QL    S
Sbjct: 1680 LSRQCRALLEMGHPDSEQISRRQSQVD--RLYVALKELGEERRVALEQQYWLYQLSRQVS 1737

Query: 2452 EEMQTVQQEQLLQETQALQQSF-----LSEKDS-------LLQRERF------------- 2486
            E    + +++++  +  L Q F     L EK S       +  RER              
Sbjct: 1738 ELEHWIAEKEVVAGSPELGQDFEHVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIEC 1797

Query: 2487 --------------IEQEKAKLEQLFQDEVAKAQQLRE------EQQRQQQQMEQERQRL 2526
                          + +  A+L +L           RE      + +  Q Q+E++R+RL
Sbjct: 1798 GHTAAATMAEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRL 1857

Query: 2527 --VASMEEARRRQHEAEEGVRRKQEELQQLEQQRRQQEELLAE-ENQRLREQLQLLEEQH 2583
              + +  E R      +  +R  + +LQ L  Q RQ +E  A+       E  + +  + 
Sbjct: 1858 PRLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASRE 1917

Query: 2584 RAALAHSEEVTASQVAATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAGILS 2643
            +  L   +E+ ++   A   + +  DAL   +   +     DG+  ++ A   +   + S
Sbjct: 1918 QEVLQGWKELLSACEDARLHVSSTADALRFHSQVRDLLSWMDGIASQIGAAD-KPRDVSS 1976

Query: 2644 AEELQRLAQGHTT-----VDELARREDV-RHYLQGRSSIA 2677
             E L    QG  T     V EL   +++ R  L  +S++A
Sbjct: 1977 VEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMA 2016



 Score = 66.6 bits (161), Expect = 5e-10
 Identities = 277/1408 (19%), Positives = 520/1408 (36%), Gaps = 194/1408 (13%)

Query: 360  KQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQADALLQSDVRLLAAGKVPQRAGEVERD 419
            ++L +E+  L    +   +    AG  +  L+  DA L   VR   A    +  G +   
Sbjct: 1064 EELGAEWGALASAAQACGEAVAAAGRLQRFLHDLDAFLDWLVRAQEAAGGSE--GPLPNS 1121

Query: 420  LDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYRLHERLVAIR-TEYNLRLKAGVAAPA 478
            L++AD+++         LK+    Q E+ Y R+    E L+A    E    L      P 
Sbjct: 1122 LEEADALLARH----AALKE-EVDQREEDYARIVAASEALLAADGAELGPGLALDEWLPH 1176

Query: 479  TQVAQVTLQSV--QRRPELEDST-----LRYLQDLLAWVEENQHRVDGAEWGVDLPSVEA 531
             ++    L  +   RR  L  +      LR L+  L  +   +  + GAE    + SVE 
Sbjct: 1177 LELGWHKLLGLWEARREALVQAHIYQLFLRDLRQALVVLRNQEMALSGAELPGTVESVEE 1236

Query: 532  QLGSHRGLHQSIEEFRAKIERA-RSDEGQLSPAT---RGAYRDCLGRLDLQYAKLLNSSK 587
             L  HR    ++E  + K++ A ++ EG L         A       L+      L + +
Sbjct: 1237 ALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQGNIYGEQAQEAVTRLLEKNQENQLRAQQ 1296

Query: 588  --ARLRSLESLHSFVAAATKELMWLNEKEEEEVGFDWSDRNTNMTAKKESYSALMRELEL 645
               +L     L  F+    +   W++EK          D N  +  +   + A M EL  
Sbjct: 1297 WMQKLHDQLELQHFLRDCHELDGWIHEKMLMARDGTRED-NHKLHKRWLRHQAFMAELAQ 1355

Query: 646  KEKKIKELQNAGDRLLREDHPARPTVESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQF 705
             ++ +++++  G +L++E      +V      ++  W+ +          L E +   Q 
Sbjct: 1356 NKEWLEKIEREGQQLMQEKPELAASVRKKLGEIRQCWAELESTTQAKARQLFEASKADQL 1415

Query: 706  FSDVREAEGQLQKLQEALRRKYSCDRSATVTRLEDLLQDAQDEKEQLNEYKGHLSGLAKR 765
                 E + +L  ++  L+     D    +  +   L+  Q  + Q+ E+   +  L  +
Sbjct: 1416 VQSFAELDKKLLHMESQLQ---DVDPGGDLATVNSQLKKLQSMESQVEEWYREVGELQAQ 1472

Query: 766  AKAVVQLKPRHPAHPMRGRLPLLAVCDYKQVEVTVHKGDE-CQLVGPAQPSHWKVLSSSG 824
              A+    P  PA           +   +Q  V    G+   +L+ P Q     +L+S  
Sbjct: 1473 TAAL----PLEPASK--------ELVGERQNAV----GERLVRLLEPLQERRRLLLASKE 1516

Query: 825  SEAAVPSVCFLVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQ-- 882
                   +       + E      RL    Q      + L    + +   Q LRR++Q  
Sbjct: 1517 LHQVAHDL-------DDELAWVQERLPLAMQ--TERGNGLQAVQQHIKKNQGLRREIQAH 1567

Query: 883  -------LIRSWSLATFRTLKPEEQRQALHSLELHYQAFLRDSQDA------GGFGPEDR 929
                   L R+ +LA+ R+ + E  R+ L  L+  + A LR++ +         F  E  
Sbjct: 1568 GPRLEEVLERAGALASLRSPEAEAVRRGLEQLQSAW-AGLREAAERRQQVLDAAFQVEQY 1626

Query: 930  LMAEREYGSCSHHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPL 989
                 E  +     + L+ S ++G  E+S  Q     L    LQLE              
Sbjct: 1627 YFDVAEVEAWLGEQELLMMSEDKGKDEQSTLQ-----LLKKHLQLE-------------- 1667

Query: 990  DKEPARECAQRIAEQQKAQAEVEGLGKGVARLSAEAEKVLALPEP-SPAAPTLRSELELT 1048
                                 VE   + +A+LS +   +L +  P S      +S+++  
Sbjct: 1668 -------------------QGVENYEESIAQLSRQCRALLEMGHPDSEQISRRQSQVDRL 1708

Query: 1049 LGKLEQVRSLSAIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKA 1108
               L+++     + LE+   +  + R     E  +   E        V A  PEL     
Sbjct: 1709 YVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKE--------VVAGSPELGQDFE 1760

Query: 1109 SLKKLRAQ-AEAQQPTFDALRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQ 1167
             +  L+ + +E    T  A R+ L    ++ + L +        +  W++    L E W 
Sbjct: 1761 HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATMAEWKD---GLNEAWA 1817

Query: 1168 AVLAQTDVRQRELEQLGRQLRYYRESADPLGAWLQDARRRQEQIQAMPLADSQAVREQLR 1227
             +L     R  +L    R+L  +   A  L   +++ RRR  ++   P     A   Q R
Sbjct: 1818 ELLELMGTR-AQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPEPRPSASSMQ-R 1875

Query: 1228 QEQALLEEIERHGEKVEECQRFAKQYINAIKDYELQLVTYKAQLEPVASPAKKPKVQSGS 1287
              +A   +++    +V + Q  A Q         L+ V      E +AS  ++ +V  G 
Sbjct: 1876 TLRAFEHDLQLLVSQVRQLQEGAAQ---------LRTVYAGEHAEAIAS--REQEVLQGW 1924

Query: 1288 ESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER-LAEVEAA 1346
            + ++    D R H S     T+  ++F S+    +   + +A Q  A ++ R ++ VE  
Sbjct: 1925 KELLSACEDARLHVSS----TADALRFHSQVRDLLSWMDGIASQIGAADKPRDVSSVEV- 1979

Query: 1347 LEKQRQLAEAHAQAKAQAEREAKEL---QQRMQEEVVRREEAAVDAQQQKRSIQEELQQL 1403
                  L   H   K + E    EL   Q+  +  ++ +   A + Q Q   +    +++
Sbjct: 1980 ------LMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADEIQAQLDKLGTRKEEV 2033

Query: 1404 RQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEA 1463
             +  +   +   +  E  + ++  +  +  +   +     R+ G +  E++ L  R E  
Sbjct: 2034 SEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQEPLLQSRELGSSVDEVEQLIRRHEAF 2093

Query: 1464 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQA 1523
                   +E    LRR               L +  K +AE +++    L      +   
Sbjct: 2094 RKAAAAWEERFSSLRR---------------LTTIEKIKAEQSKQPPTPLLG---RKFFG 2135

Query: 1524 EEAERRLRQAEVERARQVQVALETAQRSAEAELQSK---RASFAEKTAQLER------SL 1574
            +  E   + A + R    +  LE   R A   L ++   R  +  +  + ER       L
Sbjct: 2136 DPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQELKPERLQPRIDRL 2195

Query: 1575 QE-----EHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEV 1629
             E     E  A+    E+A       A AE+ R   ER     Q  A+ A       EE+
Sbjct: 2196 PEIPGRVEPAALPAAPEDAAETPATPAAAEQVRPRPER-----QESADRA-------EEL 2243

Query: 1630 AQQKSLAQAEAEKQKEEAEREAR--RRGKAEEQAVRQRELAE-QELEKQRQLAEGTAQQR 1686
             +++   + E+  Q EEA R  R  R+  AE +A     L   +++E++R+  E   +++
Sbjct: 2244 PRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRRERRERRLERQ 2303

Query: 1687 LAAEQELIRLRAETEQGEQQRQLLEEEL 1714
             ++EQE+  +R +  +G+     + E+L
Sbjct: 2304 ESSEQEM-PIRGDLVKGKATLADIVEQL 2330



 Score = 60.5 bits (145), Expect = 4e-08
 Identities = 212/1029 (20%), Positives = 372/1029 (36%), Gaps = 185/1029 (17%)

Query: 271  QWMRHHTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADK-NRSKGIYQSLEGAVQ 329
            +W+RH     E  +     E+IE    Q ++ K  EL A    K    +  +  LE   Q
Sbjct: 1342 RWLRHQAFMAELAQNKEWLEKIEREGQQLMQEKP-ELAASVRKKLGEIRQCWAELESTTQ 1400

Query: 330  AGQLKVPPGYHPLDVEKEWGKLHVAILEREKQLR------------SEFERLECLQRIVT 377
            A   ++        + + + +L   +L  E QL+            S+ ++L+ ++  V 
Sbjct: 1401 AKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPGGDLATVNSQLKKLQSMESQVE 1460

Query: 378  KLQMEAGLCE------------------------EQLNQADALLQSDVRLLAAGK-VPQR 412
            +   E G  +                        E+L +    LQ   RLL A K + Q 
Sbjct: 1461 EWYREVGELQAQTAALPLEPASKELVGERQNAVGERLVRLLEPLQERRRLLLASKELHQV 1520

Query: 413  AGEVERDLDKADSMIRLLF-----NDVQTLKDGRHPQGEQMYRRVYRLH--------ER- 458
            A +++ +L      + L       N +Q ++  +H +  Q  RR  + H        ER 
Sbjct: 1521 AHDLDDELAWVQERLPLAMQTERGNGLQAVQ--QHIKKNQGLRREIQAHGPRLEEVLERA 1578

Query: 459  --LVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRYLQ------DLLAWV 510
              L ++R+     ++ G+    +  A +  ++ +RR ++ D+  +  Q      ++ AW+
Sbjct: 1579 GALASLRSPEAEAVRRGLEQLQSAWAGLR-EAAERRQQVLDAAFQVEQYYFDVAEVEAWL 1637

Query: 511  EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIEEF-----------RAKIERARSDEGQ 559
             E +  +   + G D  S    L  H  L Q +E +           RA +E    D  Q
Sbjct: 1638 GEQELLMMSEDKGKDEQSTLQLLKKHLQLEQGVENYEESIAQLSRQCRALLEMGHPDSEQ 1697

Query: 560  LSPATRGAYRDCLGRLDLQYAKLLNSSKARLRSLES---LHSFVAAATKELMWLNEKE-- 614
            +S            ++D  Y  L    + R  +LE    L+      ++   W+ EKE  
Sbjct: 1698 ISRRQ--------SQVDRLYVALKELGEERRVALEQQYWLYQLSRQVSELEHWIAEKEVV 1749

Query: 615  --EEEVGFDWSDRNTNMTAKKESYSALMRELELK-EKKIKELQNAGDRLLREDHPARPTV 671
                E+G D+     +++  +E +S    E  +   +++  +    D L+   H A  T+
Sbjct: 1750 AGSPELGQDFE----HVSVLQEKFSEFASETGMAGRERLAAVNQMVDELIECGHTAAATM 1805

Query: 672  ESFQAALQTQWSWMLQLCCCIEAHLKENAAYFQFFSDVREAEGQLQKLQEAL-------- 723
              ++  L   W+ +L+L       L  +    +FFSD RE +GQ+++ +  L        
Sbjct: 1806 AEWKDGLNEAWAELLELMGTRAQLLAASRELHKFFSDARELQGQIEEKRRRLPRLTTPPE 1865

Query: 724  RRKYSCDRSATVTRLEDLLQDAQDEKEQLNE--------YKG-HLSGLAKRAKAVVQLKP 774
             R  +     T+   E  LQ    +  QL E        Y G H   +A R + V+Q   
Sbjct: 1866 PRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGAAQLRTVYAGEHAEAIASREQEVLQ--- 1922

Query: 775  RHPAHPMRGRLPLLAVCDYKQVEVTVHKGDECQLVGPAQPSHWKVLSSSGSEAAVPSVCF 834
                    G   LL+ C+  ++ V+            A   H +V         + S   
Sbjct: 1923 --------GWKELLSACEDARLHVS--------STADALRFHSQVRDLLSWMDGIASQIG 1966

Query: 835  LVPPPNQEAQEAVTRLEAQHQALVTLWHQLHVDMKSLLAWQSLRRDVQLIRS-------W 887
                P   +  +V  L   HQ L T   +L   +  L   Q L R + L +S        
Sbjct: 1967 AADKPRDVS--SVEVLMNYHQGLKT---ELEARVPELTTCQELGRSLLLNKSAMADEIQA 2021

Query: 888  SLATFRTLKPEEQRQ-------ALHSLELHYQAFLRDSQDAGGFGPEDRLMAEREYGSCS 940
             L    T K E   +           LE+H  A      DA     ++ L+  RE GS  
Sbjct: 2022 QLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADA-WLTAQEPLLQSRELGSSV 2080

Query: 941  HHYQQLLQSLEQGAQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKEPARECAQR 1000
               +QL++  E   +  +  +   S L+ +          T+ +++    K+P      R
Sbjct: 2081 DEVEQLIRRHEAFRKAAAAWEERFSSLRRL---------TTIEKIKAEQSKQPPTPLLGR 2131

Query: 1001 IAEQQKAQAEVEGLGKGVARLSAEAEKVLAL-PEPSPAAPTLRSELELTLGKLEQVRSLS 1059
                 K   +   L    A L         L P    A+ TL +E+   +G + Q     
Sbjct: 2132 -----KFFGDPTELAAKAAPLLRPGGYERGLEPLARRASDTLSAEVRTRVGYVRQ----- 2181

Query: 1060 AIYLEKLKTISLVIRGTQGAEEVLRAHEEQLKEAQAVPATLPELEATKASLKKLRAQAEA 1119
                 +LK   L  R  +  E   R     L    A P    E  AT A+ +++R + E 
Sbjct: 2182 -----ELKPERLQPRIDRLPEIPGRVEPAAL---PAAPEDAAETPATPAAAEQVRPRPER 2233

Query: 1120 QQPTFDA------LRDELRGAQEVGERLQQRHGERDVEVERWRERVAQLLERWQAVLAQT 1173
            Q+    A       R E + + +  E   +R      E        +  L R++ +  + 
Sbjct: 2234 QESADRAEELPRRRRPERQESVDQSEEAARRRRPERQESAEHEAAHSLTLGRYEQMERRR 2293

Query: 1174 DVRQRELEQ 1182
            + R+R LE+
Sbjct: 2294 ERRERRLER 2302



 Score = 59.3 bits (142), Expect = 8e-08
 Identities = 269/1244 (21%), Positives = 450/1244 (36%), Gaps = 196/1244 (15%)

Query: 1711 EEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE 1770
            E E A  +REAA   +  ++ + EL   R + +V +      E +   + +     L A 
Sbjct: 405  ELEKAEHEREAALRAELIRQEKLELLAQRFDHKVAMRESWLNENQRLVSQDNFGYELPAV 464

Query: 1771 AGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEK---------LAAIG 1821
                ++     A + A  E  +   +LA+  AA    +  RV A++         L  + 
Sbjct: 465  EAAMKKHEAIEADIAAYEERVQGVAELAQALAAEGYYDIRRVAAQRDSVLRQWALLTGLV 524

Query: 1822 EATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASD 1881
             A R + E  +AL++     E +  +   E  Q + L  +  QH  + ++ L Q     +
Sbjct: 525  GARRTRLEQNLALQK--VFQEMVYMVDWMEEMQAQLLSRECGQHLVEADD-LLQKHGLLE 581

Query: 1882 SELERQKGLVE---------DTLRQRRQVEEEILALKASF---------EKAAAGKAELE 1923
             ++  Q   VE           L+  +  + +++  + +          E+AA  +AELE
Sbjct: 582  GDIAAQSERVEALNAAALRFSQLQGYQPCDPQVICNRVNHVHGCLAELQEQAARRRAELE 641

Query: 1924 LE-----LGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEA 1978
                   L +    AE   R KE+  LEAA     A                 L++    
Sbjct: 642  ASRSLWALLQELEEAESWARDKERL-LEAAGGGGAAGAAGAAGTAGGAH---DLSSTARL 697

Query: 1979 ARQRKAALEEVERLKAKVEEARRLRERAEQ---------ESARQLQLAQEAAQKRLQAEE 2029
              Q K    E+   +A +++A R  E             ++   + LA+ AA  R + + 
Sbjct: 698  LAQHKILQGELGGRRALLQQALRCGEELVAAGGAVGPGADTVHLVGLAERAASARRRWQR 757

Query: 2030 KAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARVQAE--REAAQSRR 2087
               A A +++  +  + L Q  + LD L      A R A   +    +A   R A Q R 
Sbjct: 758  LEEAAARRERRLQEARALHQFGADLDGLLDWLRDAYRLAAAGDFGHDEASSRRLARQHRA 817

Query: 2088 QVEEAER--------LKQSAEEQAQARAQAQAAAEKLRK-EAEQEAARRAQAEQAALRQK 2138
               E E          +Q A     + A     A ++R  EAEQ  A     E AALR++
Sbjct: 818  LTGEVEAHRGPVSGLRRQLATLGGASGAGPLVVALQVRVVEAEQLFAE--VTEVAALRRQ 875

Query: 2139 QAADAEMEKHKKFAEQTLRQK--AQVEQELTTLRL-----QLEETDHQKNLLDEELQRLK 2191
               DA +  ++ F E    +    + EQ L ++R+      +E   H+   LD+E+  L 
Sbjct: 876  WLRDA-LAVYRMFGEVHACELWIGEKEQWLLSMRVPDSLDDVEVVQHRFESLDQEMNSLM 934

Query: 2192 AEA-----------------------------------TEAARQRSQVEEELFSVRVQME 2216
                                                   E   QR +    +  V   + 
Sbjct: 935  GRVLDVNHTVQELVEGGHPSSDEVRSCQDHLNSRWNRIVELVEQRKEEMSAVLLVENHVL 994

Query: 2217 ELSKLKARIEAENRALILRDK---------DNTQRFLQEEAEKMKQVAEEAARLSVA-AQ 2266
            E+++++A++  + RA+    +            +  LQ    +   + EEAA L+     
Sbjct: 995  EVAEVRAQVREKRRAVESAPRAGGALQWRLSGLEAALQALEPRQAALLEEAALLAERFPA 1054

Query: 2267 EAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2326
            +AARL Q AEE  A+  ALA         A Q      A A  LQ           R   
Sbjct: 1055 QAARLHQGAEELGAEWGALAS--------AAQACGEAVAAAGRLQ-----------RFLH 1095

Query: 2327 DKEQMAQQL--AEETQGFQRTLEAERQRQLEMSAEAERLKLRVAEMSRAQARAEEDAQRF 2384
            D +     L  A+E  G     E      LE   EA+ L  R A +     + EED  R 
Sbjct: 1096 DLDAFLDWLVRAQEAAGGS---EGPLPNSLE---EADALLARHAALKEEVDQREEDYARI 1149

Query: 2385 RKQAE--------EIG------EKLHRTELATQEKVTLVQTLE---IQRQQSDHDAERLR 2427
               +E        E+G      E L   EL   + + L +      +Q          LR
Sbjct: 1150 VAASEALLAADGAELGPGLALDEWLPHLELGWHKLLGLWEARREALVQAHIYQLFLRDLR 1209

Query: 2428 EAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQ----ETQALQQSFLSEKDSLLQR 2483
            +A+  L  ++  L        ++S E    Q    L       Q +Q +  + +  L Q 
Sbjct: 1210 QALVVLRNQEMALSGAELPGTVESVEEALKQHRDFLTTMELSQQKMQVAVQAAEGLLRQG 1269

Query: 2484 ERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEEARRRQHE---- 2539
              + EQ +  + +L +    +  QLR +Q  Q+   + E Q  +    E     HE    
Sbjct: 1270 NIYGEQAQEAVTRLLEKN--QENQLRAQQWMQKLHDQLELQHFLRDCHELDGWIHEKMLM 1327

Query: 2540 AEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRAALAHSEEVTASQVA 2599
            A +G R   E+  +L ++  + +  +AE  Q  +E L+ +E + +  +    E+ AS   
Sbjct: 1328 ARDGTR---EDNHKLHKRWLRHQAFMAELAQN-KEWLEKIEREGQQLMQEKPELAASVRK 1383

Query: 2600 ATKTLPNGRDALDGPAAEAEPEHSFDGLRRKVSAQRLQEAG--ILSAE-ELQRLAQGHTT 2656
                +      L+    +A+    F+  +     Q   E    +L  E +LQ +  G   
Sbjct: 1384 KLGEIRQCWAELES-TTQAKARQLFEASKADQLVQSFAELDKKLLHMESQLQDVDPG--- 1439

Query: 2657 VDELARREDVRHYLQGRSSIAGLLLKATNEKLSVYAALQRQLLSPGTALILLEAQAASG- 2715
              +LA        LQ   S      +   E  +  AAL    L P +  ++ E Q A G 
Sbjct: 1440 -GDLATVNSQLKKLQSMESQVEEWYREVGELQAQTAALP---LEPASKELVGERQNAVGE 1495

Query: 2716 ---FLLDPVRNRRLTVNEAVKEGVVGPELHHKLLSAERAVTGYKDPYTGQQISLFQ---A 2769
                LL+P++ RR  +  + +   V  +L  +L   +  +        G  +   Q    
Sbjct: 1496 RLVRLLEPLQERRRLLLASKELHQVAHDLDDELAWVQERLPLAMQTERGNGLQAVQQHIK 1555

Query: 2770 MQKGL--IVREHGIRLLEAQIATGGVIDPVHSHRVPVDVAYRRG 2811
              +GL   ++ HG RL E     G +     S R P   A RRG
Sbjct: 1556 KNQGLRREIQAHGPRLEEVLERAGALA----SLRSPEAEAVRRG 1595



 Score = 35.8 bits (81), Expect = 0.99
 Identities = 83/411 (20%), Positives = 158/411 (38%), Gaps = 45/411 (10%)

Query: 219  VDVPQPDEKSII---TYVSSLYDAMPRVPDVQDGVRANELQLRWQEYRELVLLLLQWMRH 275
            +++  PD + I    + V  LY A+  + + +    A E Q    +    V  L  W+  
Sbjct: 1688 LEMGHPDSEQISRRQSQVDRLYVALKELGEERRV--ALEQQYWLYQLSRQVSELEHWIAE 1745

Query: 276  HTAAFEERRFPSSFEEIEILWSQFLKFKEMELPAKEADKNRSKGIYQSLEGAVQAGQLKV 335
                         FE + +L     KF E       A + R   + Q ++  ++ G    
Sbjct: 1746 KEVVAGSPELGQDFEHVSVLQE---KFSEFASETGMAGRERLAAVNQMVDELIECGHTAA 1802

Query: 336  PPGYHPLD-VEKEWGKLHVAILEREKQLRSEFERLECLQRIVTKLQMEAGLCEEQLNQAD 394
                   D + + W +L   +  R + L +  E    L +  +  +   G  EE+  +  
Sbjct: 1803 ATMAEWKDGLNEAWAELLELMGTRAQLLAASRE----LHKFFSDARELQGQIEEKRRRLP 1858

Query: 395  ALLQSDVRLLAAGKVPQRAGEVERDLDKADSMIRLLFNDVQTLKDGRHPQGEQMYRRVYR 454
                   RL    +    A  ++R L   +  ++LL + V+ L++G         R VY 
Sbjct: 1859 -------RLTTPPEPRPSASSMQRTLRAFEHDLQLLVSQVRQLQEGA-----AQLRTVYA 1906

Query: 455  -LHERLVAIRTEYNLRLKAGVAAPATQVAQVTLQSVQRRPELEDSTLRY---LQDLLAWV 510
              H   +A R +  L+    + + A + A++ + S           LR+   ++DLL+W+
Sbjct: 1907 GEHAEAIASREQEVLQGWKELLS-ACEDARLHVSSTA-------DALRFHSQVRDLLSWM 1958

Query: 511  EENQHRVDGAEWGVDLPSVEAQLGSHRGLHQSIE----EFRAKIERARS---DEGQLSPA 563
            +    ++  A+   D+ SVE  +  H+GL   +E    E     E  RS   ++  ++  
Sbjct: 1959 DGIASQIGAADKPRDVSSVEVLMNYHQGLKTELEARVPELTTCQELGRSLLLNKSAMADE 2018

Query: 564  TRGAYRDCLGRLDLQYAKLLNSSKARLRSLESLHSFVAAATKELMWLNEKE 614
             + A  D LG    + ++  +     L+ +  +H F   A     WL  +E
Sbjct: 2019 IQ-AQLDKLGTRKEEVSEKWDRHWEWLQQMLEVHQFAQEAVVADAWLTAQE 2068


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.129    0.346 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 151,867,141
Number of Sequences: 37866
Number of extensions: 6976100
Number of successful extensions: 172855
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1095
Number of HSP's successfully gapped in prelim test: 1682
Number of HSP's that attempted gapping in prelim test: 28995
Number of HSP's gapped (non-prelim): 40779
length of query: 4525
length of database: 18,247,518
effective HSP length: 123
effective length of query: 4402
effective length of database: 13,590,000
effective search space: 59823180000
effective search space used: 59823180000
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 73 (32.7 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.