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Search of human proteins with 40807445
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40807445 protein regulator of cytokinesis 1 isoform 3 [Homo
sapiens]
(566 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40807445 protein regulator of cytokinesis 1 isoform 3 [Homo s... 1122 0.0
gi|40807443 protein regulator of cytokinesis 1 isoform 2 [Homo s... 1104 0.0
gi|4506039 protein regulator of cytokinesis 1 isoform 1 [Homo sa... 1104 0.0
gi|71061468 centromere protein E [Homo sapiens] 71 3e-12
gi|45439327 periplakin [Homo sapiens] 65 1e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 64 5e-10
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 61 2e-09
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 60 5e-09
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 59 9e-09
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 59 9e-09
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 59 9e-09
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 59 9e-09
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 59 9e-09
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 59 9e-09
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 59 9e-09
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 59 9e-09
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 59 1e-08
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 59 1e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 57 5e-08
gi|148746195 trichohyalin [Homo sapiens] 57 5e-08
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 57 5e-08
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 57 6e-08
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 56 1e-07
gi|153791497 ciliary rootlet coiled-coil [Homo sapiens] 55 1e-07
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 55 2e-07
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 53 7e-07
gi|87298937 centrosomal protein 110kDa [Homo sapiens] 53 7e-07
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 53 9e-07
gi|81295809 pericentrin [Homo sapiens] 53 9e-07
gi|4885583 Rho-associated, coiled-coil containing protein kinase... 52 1e-06
>gi|40807445 protein regulator of cytokinesis 1 isoform 3 [Homo
sapiens]
Length = 566
Score = 1122 bits (2902), Expect = 0.0
Identities = 566/566 (100%), Positives = 566/566 (100%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES
Sbjct: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE
Sbjct: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
Query: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ
Sbjct: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
Query: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR
Sbjct: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
Query: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE
Sbjct: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
Query: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE
Sbjct: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
Query: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA
Sbjct: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
Query: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN
Sbjct: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
Query: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG
Sbjct: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
Query: 541 RHGANKENLELNGSILSARTFKGFQI 566
RHGANKENLELNGSILSARTFKGFQI
Sbjct: 541 RHGANKENLELNGSILSARTFKGFQI 566
>gi|40807443 protein regulator of cytokinesis 1 isoform 2 [Homo
sapiens]
Length = 606
Score = 1104 bits (2856), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES
Sbjct: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE
Sbjct: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
Query: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ
Sbjct: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
Query: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR
Sbjct: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
Query: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE
Sbjct: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
Query: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE
Sbjct: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
Query: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA
Sbjct: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
Query: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN
Sbjct: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
Query: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG
Sbjct: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
Query: 541 RHGANKENLELNGSILS 557
RHGANKENLELNGSILS
Sbjct: 541 RHGANKENLELNGSILS 557
>gi|4506039 protein regulator of cytokinesis 1 isoform 1 [Homo
sapiens]
Length = 620
Score = 1104 bits (2856), Expect = 0.0
Identities = 557/557 (100%), Positives = 557/557 (100%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES
Sbjct: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE
Sbjct: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
Query: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ
Sbjct: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
Query: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR
Sbjct: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLR 240
Query: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE
Sbjct: 241 TQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVE 300
Query: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE
Sbjct: 301 LVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE 360
Query: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA
Sbjct: 361 TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
Query: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN
Sbjct: 421 FMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPN 480
Query: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG
Sbjct: 481 TPGKARKLNTTTMSNATANSSIRPIFGGTVYHSPVSRLPPSGSKPVAASTCSGKKTPRTG 540
Query: 541 RHGANKENLELNGSILS 557
RHGANKENLELNGSILS
Sbjct: 541 RHGANKENLELNGSILS 557
>gi|71061468 centromere protein E [Homo sapiens]
Length = 2701
Score = 70.9 bits (172), Expect = 3e-12
Identities = 107/469 (22%), Positives = 206/469 (43%), Gaps = 65/469 (13%)
Query: 8 AEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIK 67
++E I L K ++L+ I E + + DQ +K+HI+E L I E +S +E+
Sbjct: 1340 SQEEIKSLTKERDNLKTIKEALEVKHDQ-------LKEHIRETL-AKIQESQSKQEQ--- 1388
Query: 68 SISVCQKELNTLCSELHVEPFQEEG------ETTILQLEKDLRTQVELMRKQKKERKQEL 121
S+++ +K+ T +E F+ + E +L L K L+ + M+ KE K +L
Sbjct: 1389 SLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKE-KDDL 1447
Query: 122 KLLQEQDQELCEILCMPHYDIDSASVPSLEELN-------QFRQHVTTLRETKASRREEF 174
+ LQE Q + L +I + + + EEL + + + LR + + E
Sbjct: 1448 QRLQEVLQSESDQLKENIKEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEI 1507
Query: 175 VSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEA 234
+I++Q+ ++L + +E+ E+ F +++ I+ +Q+ + +L+ K +A
Sbjct: 1508 STIQKQLEAINDKLQNKIQEIYEK------EEQF--NIKQISEVQEKVNELKQFKEHRKA 1559
Query: 235 ---VCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMK 291
+ + +++ EL +RLQ +EE + + K +V++ALQ+E D+L+E N K
Sbjct: 1560 KDSALQSIESKMLELTNRLQESQEEIQIMIKEKEEMK-RVQEALQIERDQLKE----NTK 1614
Query: 292 KVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKEL 351
+++ ++ SQE+ F A + T+ + EI LK +E K
Sbjct: 1615 EIVAKMK-----------ESQEKEYQFLKMTAVNETQEKM----CEIEHLKEQFETQKLN 1659
Query: 352 FEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLK-EEKQRAKLQKMLPKLEEELKARI 410
E ++ E RL + T +L EE + + ++ L E + +
Sbjct: 1660 LENIE--TENIRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQLKENLRETITRDL 1717
Query: 411 ELWEQ-----EHSKAFMVNGQKFMEYVAEQW-EMHRLEKERAKQERQLK 453
E E+ H K K V+E+ E+ ++K+ LK
Sbjct: 1718 EKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLEHSNDALK 1766
Score = 52.4 bits (124), Expect = 1e-06
Identities = 105/506 (20%), Positives = 211/506 (41%), Gaps = 93/506 (18%)
Query: 9 EESIVCLQKALNH-------LRE----IWELIGIPEDQRLQRTEVVKK----HI----KE 49
E I LQK LN LRE + EL +P + R E+ K HI K+
Sbjct: 719 EGKITDLQKELNKEVEENEALREEVILLSELKSLPSEVERLRKEIQDKSEELHIITSEKD 778
Query: 50 LLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVEL 109
L + +ES + L++ I + +L T S + + T L D + ++
Sbjct: 779 KLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKSTDQEFQNFKT---LHMDFEQKYKM 835
Query: 110 MRKQKKERKQELKLLQEQDQE-------LCEILCMPHYDIDSASVPSLEELNQFRQHVTT 162
+ ++ + QE+ L ++ Q+ L L ++ + E LN+ Q
Sbjct: 836 VLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEMEQ---- 891
Query: 163 LRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLL 222
L+E +R +++R+ L E+L T + E + +++D L++L
Sbjct: 892 LKEQLENRDSTLQTVEREKTLITEKLQQTLE---EVKTLTQEKD----------DLKQLQ 938
Query: 223 RQLEMQKSQ-----NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQL 277
L++++ Q ++ V + TQ +L + L+ ++ +E + T+ S +V + L +
Sbjct: 939 ESLQIERDQLKSDIHDTVNMNIDTQ-EQLRNALESLKQHQETINTLKSKISEEVSRNLHM 997
Query: 278 E----------------VDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPF 321
E +D+ ++L+ +N + + ++ + ++QR+ F+
Sbjct: 998 EENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEI--------IEQQRKIFSLI 1049
Query: 322 CAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNR 381
++ + +L+ AE +LK + + E+ ++ EE L E +++ + N
Sbjct: 1050 QEKNELQQMLESVIAEKEQLKTDLKENIEMT--IENQEELRLLGDELKKQQEIVAQEKNH 1107
Query: 382 GGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL 441
+K+E + ++ L ++EE+LK E S+ Q+ + E EM +
Sbjct: 1108 A---IKKEGELSRTCDRLAEVEEKLK--------EKSQQLQEKQQQLLNVQEEMSEMQKK 1156
Query: 442 EKERAKQERQLKNKKQT----ETEML 463
E + +LKNK+ T ETE L
Sbjct: 1157 INEIENLKNELKNKELTLEHMETERL 1182
Score = 50.8 bits (120), Expect = 3e-06
Identities = 97/460 (21%), Positives = 195/460 (42%), Gaps = 74/460 (16%)
Query: 47 IKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQ 106
+ L+D + ++ L I+ QKELN E E +EE +L K L ++
Sbjct: 700 LTSLIDGKVPKDLLCNLELEGKITDLQKELNKEVEEN--EALREE--VILLSELKSLPSE 755
Query: 107 VELMRKQKKERKQELKLL-QEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRE 165
VE +RK+ +++ +EL ++ E+D+ E++ +S LEE+ + + + T +
Sbjct: 756 VERLRKEIQDKSEELHIITSEKDKLFSEVV-----HKESRVQGLLEEIGKTKDDLATTQS 810
Query: 166 TKASRREEFVSIKRQIILCMEELDHTPDTSFER--DVVCEDEDAFCLSLENIA-TLQKLL 222
S +EF + K T FE+ +V E+ + + N++ QK
Sbjct: 811 NYKSTDQEFQNFK------------TLHMDFEQKYKMVLEENERMNQEIVNLSKEAQKFD 858
Query: 223 RQLEMQKSQNEAVCEGLRTQIRELWDRLQIPE------EEREAVATIMSGSKAKVRKALQ 276
L K++ + L+ + RE+ +RL E E R++ + K + + LQ
Sbjct: 859 SSLGALKTELSYKTQELQEKTREVQERLNEMEQLKEQLENRDSTLQTVEREKTLITEKLQ 918
Query: 277 LEVDRLEELKMQ--NMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLH 334
++ ++ L + ++K++ E++++E Q + + ESL Q H
Sbjct: 919 QTLEEVKTLTQEKDDLKQLQESLQIERDQLKSD-IHDTVNMNIDTQEQLRNALESLKQ-H 976
Query: 335 DAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERK-----------ASDPNRFTN--R 381
I LK+ ++ +E+ + E T EF++K A + T +
Sbjct: 977 QETINTLKS--KISEEVSRNLHMEENTGETKDEFQQKMVGIDKKQDLEAKNTQTLTADVK 1034
Query: 382 GGNLLKEEK-------QRAKLQKML-------PKLEEELKARIELW-EQEHSKAFMVNGQ 426
++++++ ++ +LQ+ML +L+ +LK IE+ E + + +
Sbjct: 1035 DNEIIEQQRKIFSLIQEKNELQQMLESVIAEKEQLKTDLKENIEMTIENQEELRLLGDEL 1094
Query: 427 KFMEYVAEQWEMHRLEKE---------RAKQERQLKNKKQ 457
K + + Q + H ++KE A+ E +LK K Q
Sbjct: 1095 KKQQEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQ 1134
Score = 45.8 bits (107), Expect = 1e-04
Identities = 95/475 (20%), Positives = 207/475 (43%), Gaps = 61/475 (12%)
Query: 1 MRRSEVLAE--ESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEE 58
+R +++L E E + + K + LR + E + + DQ +K++++E + + ++
Sbjct: 1668 IRLTQILHENLEEMRSVTKERDDLRSVEETLKVERDQ-------LKENLRETITRDLEKQ 1720
Query: 59 ESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERK 118
E LK + + KE +L ++ E I ++KDL + ++ Q + +
Sbjct: 1721 EELK-----IVHMHLKEHQETIDKLRGIVSEKTNE--ISNMQKDLEHSNDALKAQDLKIQ 1773
Query: 119 QELKL----LQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEF 174
+EL++ L+EQ + + ++ + D S + N + ++E KA+ +
Sbjct: 1774 EELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQEKIQELKANEHQ-L 1832
Query: 175 VSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEA 234
+++K+ + +++ ++ + + L +EN+ QKL LE KS +
Sbjct: 1833 ITLKKDVNETQKKVSEMEQ--LKKQIKDQSLTLSKLEIENLNLAQKLHENLEEMKSVMKE 1890
Query: 235 VCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNM---- 290
R +R + + L++ ER+ + + +KA+ LE+ +ELK M
Sbjct: 1891 -----RDNLRRVEETLKL---ERDQLKESLQETKAR-----DLEIQ--QELKTARMLSKE 1935
Query: 291 -KKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEV-H 348
K+ ++ +R ++ + Q Q+ + E LQ + +++R+K + H
Sbjct: 1936 HKETVDKLREKISEKTIQISDIQKDLDKSKDELQKKIQE--LQKKELQLLRVKEDVNMSH 1993
Query: 349 KELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKA 408
K++ E Q ++ L + D + T + L+E + AK + L +++E LK
Sbjct: 1994 KKINEMEQLKKQFEAQNLSMQSVRMDNFQLTKKLHESLEEIRIVAKERDELRRIKESLK- 2052
Query: 409 RIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEML 463
E++ A + E +A + H+++ E+ R L + +Q TE L
Sbjct: 2053 ----MERDQFIATL------REMIARDRQNHQVKPEK----RLLSDGQQHLTESL 2093
Score = 32.0 bits (71), Expect = 1.6
Identities = 54/246 (21%), Positives = 102/246 (41%), Gaps = 28/246 (11%)
Query: 7 LAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDM-------MIAEEE 59
L + + V Q N L EL+ EDQ + E + E + M I + +
Sbjct: 562 LVKHAEVYNQDLENELSSKVELLREKEDQIKKLQEYIDSQKLENIKMDLSYSLESIEDPK 621
Query: 60 SLKERLIKSISVC---QKELNTLCSE-LHVEPFQEEGETTILQLEKDLRTQVELMRKQKK 115
+K+ L + +V ++E L SE L ++ +E TT Q+E D++ + +KK
Sbjct: 622 QMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYKQMENDIQLYQSQLEAKKK 681
Query: 116 ERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFV 175
+ K LQ E+ ++ + + + +LE +T L++ EE
Sbjct: 682 MQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCNLE----LEGKITDLQKELNKEVEENE 737
Query: 176 SIKRQIILCMEELDHTP-----------DTSFERDVVCEDED-AFCLSLENIATLQKLLR 223
+++ ++IL + EL P D S E ++ ++D F + + +Q LL
Sbjct: 738 ALREEVIL-LSELKSLPSEVERLRKEIQDKSEELHIITSEKDKLFSEVVHKESRVQGLLE 796
Query: 224 QLEMQK 229
++ K
Sbjct: 797 EIGKTK 802
>gi|45439327 periplakin [Homo sapiens]
Length = 1756
Score = 65.5 bits (158), Expect = 1e-10
Identities = 123/515 (23%), Positives = 208/515 (40%), Gaps = 114/515 (22%)
Query: 24 EIWELIGIPEDQRLQRTEVVKKHIKELLD-------MMIAEEESLKERLIKSISVCQKEL 76
EIW L + + R EV+KK +L+ +AEE+ + L + + Q +L
Sbjct: 919 EIWTLRNQGPQESVVRKEVLKKVPDPVLEESFQQLQRTLAEEQHKNQLLQEELEALQLQL 978
Query: 77 NTLCSELHVEPFQEEGETTILQLEKD---------LRTQVELMRKQKKERKQELKLLQEQ 127
L E + QE +L++E D LR ++E +R+QK R+ E+ LLQ++
Sbjct: 979 RALEQETR-DGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRRQKGAREAEVLLLQQR 1037
Query: 128 DQELCEILCMPHYDIDSASV------PSLE----ELNQFRQHVTTLRE----------TK 167
L E + V P LE +L + Q LRE K
Sbjct: 1038 VAALAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREKQEEELSFLQDK 1097
Query: 168 ASRREEFVSIKRQIILCMEELDHTPDTSFERDV-----VCEDEDAFCLSLENIATLQKLL 222
R E+ ++ I E L D + ER+V EDE A + + T +LL
Sbjct: 1098 LKRLEKERAMAEGKITVKEVLKVEKDAATEREVSDLTRQYEDEAAKARASQREKT--ELL 1155
Query: 223 RQLEMQKSQNEAVCEGLRTQIRELWD------------RLQIPEEER------EAVATIM 264
R++ + +N V ++ ++RE+ RL++ E+ER E + +
Sbjct: 1156 RKIWALEEENAKVV--VQEKVREIVRPDPKAESEVANLRLELVEQERKYRGAEEQLRSYQ 1213
Query: 265 SGSKAKVRKALQLEVDRL--EELKMQ---NMKKVIEAIRVELVQYWDQCFYSQEQRQAFA 319
S +A R+ Q+EV + E +K + M+K ++ +R E+V
Sbjct: 1214 SELEALRRRGPQVEVKEVTKEVIKYKTDPEMEKELQRLREEIV----------------- 1256
Query: 320 PFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFT 379
D T L++ D EI +LK + K+ VQ +E + L+F+
Sbjct: 1257 -----DKTR-LIERCDLEIYQLKKEIQALKDTKPQVQT-KEVVQEILQFQEDPQTKEEVA 1309
Query: 380 NRGGNLLKE-------EKQRAKLQKMLPKLEEEL---KARI---ELWEQEHSKAFMVNGQ 426
+ L +E E++RA ++ + + EEEL K R+ E+ E
Sbjct: 1310 SLRAKLSEEQKKQVDLERERASQEEQIARKEEELSRVKERVVQQEVVRYEEEPGLRAEAS 1369
Query: 427 KFMEYVAEQW--------EMHRLEKERAKQERQLK 453
F E + + E+ RL++ R + ERQL+
Sbjct: 1370 AFAESIDVELRQIDKLRAELRRLQRRRTELERQLE 1404
Score = 38.1 bits (87), Expect = 0.022
Identities = 78/395 (19%), Positives = 165/395 (41%), Gaps = 62/395 (15%)
Query: 100 EKDLRTQVELMRKQKKERKQELKLLQEQDQELCE-----ILCMPHYDIDSASVPSLEELN 154
E D +Q+E K +K E+ +++ Q++C + Y++++ + SL +L
Sbjct: 756 ETDSLSQMETKLKNQKNLLDEIASREQEVQKICANSQQYQQAVKDYELEAEKLRSLLDLE 815
Query: 155 QFR-QHV----------TTLRETKASRREEFV---SIKRQ----IILCMEELDHTPDTSF 196
R HV T ++E +A+ +F +I RQ + + L P+
Sbjct: 816 NGRSSHVSKRARLQSPATKVKEEEAALAAKFTEVYAINRQRLQNLEFALNLLRQQPEVEV 875
Query: 197 ERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD-RLQIPEE 255
+ + + + K+ ++L+ + + + +++ E+W R Q P+E
Sbjct: 876 THETLQRNRPD-----SGVEEAWKIRKELDEETERRRQLENEVKSTQEEIWTLRNQGPQE 930
Query: 256 ---EREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQ 312
+E + + + + LQ + E+ K Q +++ +EA++++L Q
Sbjct: 931 SVVRKEVLKKVPDPVLEESFQQLQRTLAE-EQHKNQLLQEELEALQLQLRA------LEQ 983
Query: 313 EQRQAFAPFCAEDYTESLLQLHDA-EIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERK 371
E R + ++ A E+++L+ E + QK + L +R
Sbjct: 984 ETRDGGQEYVVKEVLRIEPDRAQADEVLQLREELEALRR-----QKGAREAEVLLLQQRV 1038
Query: 372 ASDPNRFTNRGGNLLKEEKQRAK---LQKMLPKLEE--ELKARIELWEQEHSKAFMVNGQ 426
A+ L EEK RA+ +K + KL+ +L+A + +++H + + +
Sbjct: 1039 AA------------LAEEKSRAQEKVTEKEVVKLQNDPQLEAEYQQLQEDHQRQDQLREK 1086
Query: 427 KFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETE 461
+ E Q ++ RLEKERA E ++ K+ + E
Sbjct: 1087 QEEELSFLQDKLKRLEKERAMAEGKITVKEVLKVE 1121
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 63.5 bits (153), Expect = 5e-10
Identities = 99/448 (22%), Positives = 195/448 (43%), Gaps = 35/448 (7%)
Query: 19 LNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
++ L + W+ G E Q L KK ++ + E ++L L ++ ++ +EL
Sbjct: 152 ISRLHDSWKFAGELE-QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKE 209
Query: 79 LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCM- 137
++L QE+ LQL + +++++L K+ K + + KLL Q Q E +
Sbjct: 210 KNAKL-----QEK-----LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 259
Query: 138 PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFE 197
SA + + E N+ + +E K R+EE + + + I EE +
Sbjct: 260 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMR 319
Query: 198 R--DVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
R +++ E E+ E + ++ +R+LE + + E + E + E R Q +
Sbjct: 320 RQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQ 379
Query: 256 EREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
E+EA M + K+R+ Q E R +E MQ + E + + + W+Q QEQ
Sbjct: 380 EQEAK---MWRQEEKIRE--QEEKIREQEEMMQEQE---EKMGEQEEKMWEQEEEMQEQE 431
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
+ E E ++ + E + E + + E +K E E E K +
Sbjct: 432 EKMRR-QEEKIREQEKKIREQE----EKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ 486
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIE--LWEQEHSKAFMVNGQKFMEYVA 433
R ++E++++ + Q+ + +EE+ E +WEQE M ++ M+
Sbjct: 487 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEK---MCEQEEKMQ--E 541
Query: 434 EQWEMHRLEKERAKQERQLKNKKQTETE 461
++ +M R E++ +QE +L+ +++ E
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQE 569
Score = 46.6 bits (109), Expect = 6e-05
Identities = 67/313 (21%), Positives = 139/313 (44%), Gaps = 44/313 (14%)
Query: 15 LQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQK 74
LQ +HL + + + +++ E+ + ++ + M +EE ++ER
Sbjct: 251 LQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQER---------- 300
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELM-RKQKKERKQELKLLQEQDQELCE 133
E +E E I + E+ +R Q E+M K++K R+QE +++ E+++++ E
Sbjct: 301 -----------EEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQE-EMMWEKEEKIRE 348
Query: 134 ILCMPHYDIDSASVPSLEELNQFRQHVTTL-----RETKASRREEFVSIKRQIILCMEEL 188
+ H + + EE Q + + +E K R+EE + + + I EE+
Sbjct: 349 LEEKMH---EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEM 405
Query: 189 DHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD 248
+ + + E E+ E + ++ +R+ E + + E +IRE +
Sbjct: 406 -----MQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 249 RLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVI----EAIR--VELV 302
+Q EE+ M +AK+++ Q E R +E K++ +K I E IR E++
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQE--QEEKMRRQEEKIREQEKKIREQEEKIREQEEMM 518
Query: 303 QYWDQCFYSQEQR 315
Q ++ + QE++
Sbjct: 519 QEQEEKMWEQEEK 531
Score = 45.1 bits (105), Expect = 2e-04
Identities = 76/374 (20%), Positives = 172/374 (45%), Gaps = 51/374 (13%)
Query: 108 ELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETK 167
E +R++ + + Q +++L Q EL L + +V LE + R ++ L ++
Sbjct: 107 EALRRELEAQVQTIRILTCQKTELQMALYYSQH-----AVKQLE--GEARDLISRLHDSW 159
Query: 168 --ASRREEFVSI----KRQIILCMEELDHTPDT---SFERDVVCEDEDAFCLSLENIATL 218
A E+ +S K++ +EEL D R+ + ++E E A L
Sbjct: 160 KFAGELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTITDEE-----LKEKNAKL 214
Query: 219 QKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLE 278
Q+ L+ +E +KS+ + + L+ ++ +L +P+++ +A A + V LQ +
Sbjct: 215 QEKLQLVESEKSEIQLNVKELKRKLERA--KLLLPQQQLQAEADHLGKELQSVSAKLQAQ 272
Query: 279 VD------RLEELKMQNMKKVIEAI--RVELVQYWDQCFYSQEQ---RQAFAPFCAEDYT 327
V+ RL + + + M + E I R E +Q ++ QE+ RQ + E+
Sbjct: 273 VEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKM 332
Query: 328 ---ESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGN 384
E ++ + +I L+ +++ E +K +E ++ E E++ + +
Sbjct: 333 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKI-REQEKRQEQEAKMWRQEEK 391
Query: 385 LLKEEKQRAKLQKMLPKLEEELKARIE-LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEK 443
+ ++E++ + ++M+ + EE++ + E +WEQE E ++ +M R E+
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEE------------EMQEQEEKMRRQEE 439
Query: 444 ERAKQERQLKNKKQ 457
+ +QE++++ +++
Sbjct: 440 KIREQEKKIREQEE 453
Score = 42.0 bits (97), Expect = 0.002
Identities = 56/248 (22%), Positives = 112/248 (45%), Gaps = 30/248 (12%)
Query: 1 MRRSEVLA---EESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIK--ELLDMMI 55
MRR E + EE I L++ ++ +I E ++++ Q E +++ K E M
Sbjct: 332 MRRQEEMMWEKEEKIRELEEKMHEQEKIRE-----QEEKRQEEEKIREQEKRQEQEAKMW 386
Query: 56 AEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQ-- 113
+EE ++E+ K +E + E E E E + + E++++ Q E MR+Q
Sbjct: 387 RQEEKIREQEEKI-----REQEEMMQEQ--EEKMGEQEEKMWEQEEEMQEQEEKMRRQEE 439
Query: 114 ------KKERKQELKLLQEQD--QELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRE 165
KK R+QE K+ ++++ QE E + + E+ + R+ +RE
Sbjct: 440 KIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIRE 499
Query: 166 TKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQL 225
+ RE+ I+ Q + E+ + + + + +CE E+ E + ++ +R+
Sbjct: 500 QEKKIREQEEKIREQEEMMQEQEEKMWE---QEEKMCEQEEKMQEQEEKMRRQEEKMREQ 556
Query: 226 EMQKSQNE 233
E++ Q E
Sbjct: 557 EVRLRQQE 564
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 61.2 bits (147), Expect = 2e-09
Identities = 96/454 (21%), Positives = 196/454 (43%), Gaps = 59/454 (12%)
Query: 19 LNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
++ L + W+ G E Q L KK ++ + E ++L L ++ ++ +EL
Sbjct: 164 ISRLHDSWKFAGELE-QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKE 221
Query: 79 LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCM- 137
++L QE+ LQL + +++++L K+ K + + KLL Q Q E +
Sbjct: 222 KNAKL-----QEK-----LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271
Query: 138 PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFE 197
SA + + E N+ + +E K R+EE + + I EE +
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEE-----KIREQ 326
Query: 198 RDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEER 257
+ + E E+ E + ++ +R+ E + E E +R Q +W++ EE+
Sbjct: 327 EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE---EKMRRQEEMMWEK----EEKM 379
Query: 258 EAVATIMSGSKAKVR----KALQLEVDRLEELKMQNMKKVIEAIR--VELVQYWDQCFYS 311
+M + K+R K + E R +E K Q +K+ E + + + W Q
Sbjct: 380 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 439
Query: 312 QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELF---EGVQKWEETWRLFLEF 368
+EQ + + + + ++H+ E +R + + +E++ E + + EE WR
Sbjct: 440 REQEEKIREQEKKMWRQE-EKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR----- 493
Query: 369 ERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIE-LWEQEHSKAFMVNGQK 427
+ + + K+E++ + ++ + + EE+++ + E +W QE
Sbjct: 494 -----QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQE----------- 537
Query: 428 FMEYVAEQWEMHRLEKERAKQERQLKNKKQTETE 461
E + EQ EM R E++ +QE+ + +K+ E E
Sbjct: 538 --EKIREQEEMWREEEKMHEQEKIWEEEKRQEQE 569
Score = 53.5 bits (127), Expect = 5e-07
Identities = 89/453 (19%), Positives = 184/453 (40%), Gaps = 56/453 (12%)
Query: 24 EIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSEL 83
E+W + +++++ R E + I+E + + +EE ++E+ K +K
Sbjct: 289 ELWNRLNQQQEEKMWRQE---EKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMW 345
Query: 84 HVEPFQEEGETTILQLEKDLRTQVELM-RKQKKERKQELKLLQEQDQELCEILCMPHYDI 142
E E + + E+ +R Q E+M K++K R+QE +++ E+++++ E+ H
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQE-EMMWEKEEKIRELEEKMH--- 401
Query: 143 DSASVPSLEELNQFRQHVTTL------------RETKASRREEFVSIKRQIILCMEELDH 190
+ + EE Q + + +E K +EE + + + + EE H
Sbjct: 402 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIH 461
Query: 191 TPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRL 250
+ E + E E+ + E I +++ RQ E Q E + R Q ++W +
Sbjct: 462 EQEKIREEEKRQEQEEMWRQE-EKIHEQEEIWRQKEKMHEQEEKI----RKQEEKVWRQE 516
Query: 251 QIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFY 310
+ E+ E + + K + E EE KM +K+ E E Q + +
Sbjct: 517 EKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEE---EKRQEQEDKMW 573
Query: 311 SQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFER 370
QE++ + E + + + +++ E +E E + K EE R E E
Sbjct: 574 RQEEK-------IREQEEKVWRQEE----KIREQEEKRQEQEEKMWKQEEKIR---EQEE 619
Query: 371 KASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFME 430
K ++E++++ + Q+ + +EE+ E E + +K E
Sbjct: 620 K--------------IQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQE 665
Query: 431 YVAEQWEMHRLEKERAKQERQLKNKKQTETEML 463
W +E+ K+ R+ + K + + EM+
Sbjct: 666 QEETMWRQEEKIREQEKKIREQEEKIREQEEMM 698
Score = 44.3 bits (103), Expect = 3e-04
Identities = 79/421 (18%), Positives = 179/421 (42%), Gaps = 39/421 (9%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
MRR E + E +++ + E E + E+ ++ E +++ +++ + E+
Sbjct: 351 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 410
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
K + + I +K E E E I + EK + Q E + +Q+K R++E
Sbjct: 411 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 470
Query: 121 LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQ 180
+ Q+QE E+ + + +E ++ +E K R+EE I+ Q
Sbjct: 471 ----KRQEQE--EMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEE--KIREQ 522
Query: 181 IILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNE--AVCEG 238
E++ + + ++ +++ E + +K+ + + Q+ +++ E
Sbjct: 523 ----EEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEK 578
Query: 239 LRTQIRELW---DRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIE 295
+R Q ++W ++++ EE+R+ M + K+R+ + ++ EE + +K+ E
Sbjct: 579 IREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQ-EEKIQEQEEKIREQEEKIRE 637
Query: 296 AIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGV 355
+ E+ Q ++ QE++ C ++ E + + + + + E K++ E
Sbjct: 638 --QEEMTQEQEEKMGEQEEK-----MCEQE--EKMQEQEETMWRQEEKIREQEKKIREQE 688
Query: 356 QKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQ 415
+K E + E E K + +EEK + +KM + E+ + ++WEQ
Sbjct: 689 EKIREQEEMMQEQEEKMWE------------QEEKMCEQEEKMQEQEEKMRRQEEKMWEQ 736
Query: 416 E 416
E
Sbjct: 737 E 737
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 60.1 bits (144), Expect = 5e-09
Identities = 91/421 (21%), Positives = 186/421 (44%), Gaps = 61/421 (14%)
Query: 56 AEEESLKERLIKSISV---CQKELNTLCSELHVEPFQEEG----ETTILQLEKDLRTQVE 108
AE + L + L +S+S Q E N L + L+ + QEE E I + E+ ++ Q E
Sbjct: 265 AEADHLGKEL-QSVSAKLQAQVEENELWNRLNQQ--QEEKMWRQEEKIQEWEEKIQEQEE 321
Query: 109 LMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKA 168
+R+Q+++ +++ + ++ Q++ + E EE + ++ + +E K
Sbjct: 322 KIREQEEKIREQEEKMRRQEEMMWE----------------KEEKMRRQEEMMWEKEEKM 365
Query: 169 SRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQ 228
R EE + K + I +EE H + E++ ++E+ + K+ RQ E
Sbjct: 366 RRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 425
Query: 229 KSQNEAVCEGLRTQIRELW-------DRLQIPEEEREAVATIMSGSKAKVRKALQLEVDR 281
+ Q E + R Q +++W ++ +I EEE+ M + K+R+ Q E+ R
Sbjct: 426 REQEEKI----REQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE--QEEIWR 479
Query: 282 LEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRL 341
+E KM +K IR + + W QE++ D E + + + +
Sbjct: 480 QKE-KMHEQEK----IRKQEEKVW-----RQEEKM-------HDQEEKIREQEEKMWRQE 522
Query: 342 KNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPK 401
+ E +++ E +K E + E E K + + ++E++ + ++ + +
Sbjct: 523 EKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQEEKIRE 582
Query: 402 LEEELKARIE-LWEQEHSKAFMVNGQKFMEYVAEQWEMHR--LEKERAKQERQLKNKKQT 458
+E+++ + E +WEQE + + E + WE E+E QE++ K ++Q
Sbjct: 583 QKEKIREQEEKIWEQE--EKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQE 640
Query: 459 E 459
E
Sbjct: 641 E 641
Score = 52.4 bits (124), Expect = 1e-06
Identities = 94/453 (20%), Positives = 189/453 (41%), Gaps = 44/453 (9%)
Query: 19 LNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
++ L + W+ G E Q L KK ++ + E ++L L ++ ++ +EL
Sbjct: 164 ISRLHDSWKFAGELE-QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKE 221
Query: 79 LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLL--QEQDQELCEILC 136
++L QE+ LQL + +++++L K+ K + + KLL Q+Q Q + L
Sbjct: 222 KNAKL-----QEK-----LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 271
Query: 137 MPHYDIDSASVPSLEE------LNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDH 190
+ + +EE LNQ ++ +E K EE + + + I EE
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 191 TPDTSFER--DVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD 248
+ R +++ E E+ E + ++ +R+LE + E +IREL +
Sbjct: 332 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEE-------KIRELEE 384
Query: 249 RLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVI----EAIRVELVQY 304
++ E+ RE + + K + E + +E KM ++ I E IR + +
Sbjct: 385 KMHEQEKIRE-----QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM 439
Query: 305 WDQCFYSQEQRQAFAPFCAEDYTESLLQ----LHDAEIVRLKNYYEVHKELFEGVQK-WE 359
W Q EQ + ++ E Q EI R K +++ + +K W
Sbjct: 440 WRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWR 499
Query: 360 ETWRLFLEFERKASDPNRFTNRGGNLLK-EEKQRAKLQKMLPKLEEELKARIELWEQEHS 418
+ ++ + E+ + + + + EEK R + +K+ + E + ++ EQE
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 419 KAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQ 451
++ E + EQ E R +KE+ +++ +
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKEKIREQEE 592
Score = 47.4 bits (111), Expect = 4e-05
Identities = 58/259 (22%), Positives = 110/259 (42%), Gaps = 44/259 (16%)
Query: 215 IATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKA 274
I L K L ++ +N E L+ + +L ++LQ+ E E+ + + K K+ +A
Sbjct: 195 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERA 254
Query: 275 --------LQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDY 326
LQ E D L + ++Q++ ++A +VE + W++ QE++
Sbjct: 255 KLLLPQQQLQAEADHLGK-ELQSVSAKLQA-QVEENELWNRLNQQQEEK----------- 301
Query: 327 TESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLL 386
+ E +E E +Q+ EE R E E K + R ++
Sbjct: 302 --------------MWRQEEKIQEWEEKIQEQEEKIR---EQEEKIREQEEKMRRQEEMM 344
Query: 387 --KEEKQRAKLQKMLPKLEEELKARIELWEQEHS----KAFMVNGQKFMEYVAEQWEMHR 440
KEEK R + + M K E+ + +WE+E + M +K E ++ E +
Sbjct: 345 WEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 404
Query: 441 LEKERAKQERQLKNKKQTE 459
+ ++ +QE++ K +Q E
Sbjct: 405 IREQEKRQEQEAKMWRQEE 423
Score = 41.6 bits (96), Expect = 0.002
Identities = 43/233 (18%), Positives = 110/233 (47%), Gaps = 27/233 (11%)
Query: 33 EDQRLQRTEVVKKHIKELLDMMIAEEESL---KERLIKSISVCQKELNTLCSELHVEPFQ 89
E++R ++ E+ ++ K I E+E + KE++ + + ++E E + +
Sbjct: 455 EEKRQEQEEMWRQEEK------IREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQE 508
Query: 90 E---EGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSAS 146
E E E + + E+ +R Q E +R+Q+++ +++ +++QEQ++++ E
Sbjct: 509 EKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGE------------Q 556
Query: 147 VPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDED 206
++E + R+ +RE + RE+ I+ Q E+ + + + +++ E E+
Sbjct: 557 EEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIRE---QEEMMQEQEE 613
Query: 207 AFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREA 259
E + ++ +++ E + + E ++R+ +++Q +E EA
Sbjct: 614 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEA 666
Score = 37.7 bits (86), Expect = 0.028
Identities = 63/325 (19%), Positives = 136/325 (41%), Gaps = 15/325 (4%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
MRR E + E +++ + E E + E+ ++ E +++ +++ + E+
Sbjct: 337 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQE 396
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
K + + I +K E E E I + EK + Q E + +Q+K R++E
Sbjct: 397 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE 456
Query: 121 LKLLQEQ-------DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREE 173
+ QE+ +E EI + + EE ++ +E K +EE
Sbjct: 457 KRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEE 516
Query: 174 FVSIKRQIILCMEELDHTPDTSF--ERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQ 231
+ + + I EE + + +++ E E+ E + +K+ RQ E + Q
Sbjct: 517 KMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIREQ 576
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMK 291
E + E + +IRE +++ EE+ +M + K+ + + ++ E+++ Q
Sbjct: 577 EEKIRE-QKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-- 633
Query: 292 KVIEAIRVELVQYWDQCFYSQEQRQ 316
E +R + + W+Q ++Q +
Sbjct: 634 ---EKMRRQEEKMWEQEVRLRQQEE 655
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 59.3 bits (142), Expect = 9e-09
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)
Query: 38 QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
+ E +K+ +E + +A +E+ + R + + Q+ L ++ E Q E T L
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2325
Query: 98 QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
+ E EL+++QK+ +++ + LQE +++ + L EE F+
Sbjct: 2326 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2365
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + R+ + E +K ++ M + +R +E L +AT
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 218 LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
+K L++ LE+Q+ Q++ E LR I EL E E+E + + K L
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2469
Query: 276 QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
QL+ + ++ ++ + + + +A++ + D S QR+ F E L QL
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2521
Query: 336 AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
E+ + + E + + Q +E RL E R+ + R L++ E+Q
Sbjct: 2522 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKA 420
R + +++L + + L+ +++L E++H A
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Score = 52.4 bits (124), Expect = 1e-06
Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
EL TL S+ +++ E T+ ++E++ R E R +++ER E++ E+ ++L E
Sbjct: 1325 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1378
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
H + + +EL Q Q RE A ++ KR I +++L + +
Sbjct: 1379 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1431
Query: 195 SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
ER + +E+ + L+ AT L+ + E QK Q
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
+ E LR Q+++ R + E E + + + + ++ALQ LE RL+ + +
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551
Query: 291 KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
+ E R VQ + Q +R +FA A+ E LQ + +L+
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1609
Query: 345 YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
E +E +++W+ E RL L+ E A + KEE
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1668
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
+R ++ K EE+ + EL EQE K + + +A + E+ RL E E+ +
Sbjct: 1669 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 448 QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
Q+RQL + E L A KR+ L ++ S A A R
Sbjct: 1727 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Score = 49.7 bits (117), Expect = 7e-06
Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)
Query: 38 QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
QR E +EL + +AEE + +L + + Q+ + E G
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1843
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
E T L+T+ E+ K+K+ + L+ L E Q + L E DI+
Sbjct: 1844 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1892
Query: 149 SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
E L Q R+ + E + E+ + +RQ+ EE SFE+ + E
Sbjct: 1893 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1943
Query: 209 CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
L LE N + Q E++ ++ + + RE +R+Q EEE
Sbjct: 1944 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002
Query: 257 -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
R+A + KAKV +A +L +R E+ + ++ EA + L ++E+
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2053
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
AFA E + LQ + + +L+ E + + EE ++ ER+A+
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2107
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
R L + +++A+ + E+L+ EQE ++ + A
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2164
Query: 436 WEMHRLEKERAKQERQLKNKKQTETEM 462
EM EK + E+ L+ K Q E E+
Sbjct: 2165 AEM---EKHKKFAEQTLRQKAQVEQEL 2188
Score = 38.9 bits (89), Expect = 0.013
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
M R++ AEE +K + E +L RTE+ K + + L++ +
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2440
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ ERL ++I+ ++E L + E +LQL+ + E+ Q+++
Sbjct: 2441 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2484
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
QE + LQ+ + L I+ LE+L Q LRE + ++++
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 177 IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
+++++ MEE + R E E + Q+ L+QLE Q+ Q E
Sbjct: 2544 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2584
Query: 237 EGLRTQIRELWDRLQIPEEEREA 259
E L + + L ++LQ+ EE+ A
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRA 2607
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 59.3 bits (142), Expect = 9e-09
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)
Query: 38 QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
+ E +K+ +E + +A +E+ + R + + Q+ L ++ E Q E T L
Sbjct: 2272 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2329
Query: 98 QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
+ E EL+++QK+ +++ + LQE +++ + L EE F+
Sbjct: 2330 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2369
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + R+ + E +K ++ M + +R +E L +AT
Sbjct: 2370 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2428
Query: 218 LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
+K L++ LE+Q+ Q++ E LR I EL E E+E + + K L
Sbjct: 2429 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2473
Query: 276 QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
QL+ + ++ ++ + + + +A++ + D S QR+ F E L QL
Sbjct: 2474 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2525
Query: 336 AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
E+ + + E + + Q +E RL E R+ + R L++ E+Q
Sbjct: 2526 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2583
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKA 420
R + +++L + + L+ +++L E++H A
Sbjct: 2584 RRQQEELLAEENQRLREQLQLLEEQHRAA 2612
Score = 52.4 bits (124), Expect = 1e-06
Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
EL TL S+ +++ E T+ ++E++ R E R +++ER E++ E+ ++L E
Sbjct: 1329 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1382
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
H + + +EL Q Q RE A ++ KR I +++L + +
Sbjct: 1383 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1435
Query: 195 SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
ER + +E+ + L+ AT L+ + E QK Q
Sbjct: 1436 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1495
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
+ E LR Q+++ R + E E + + + + ++ALQ LE RL+ + +
Sbjct: 1496 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1555
Query: 291 KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
+ E R VQ + Q +R +FA A+ E LQ + +L+
Sbjct: 1556 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1613
Query: 345 YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
E +E +++W+ E RL L+ E A + KEE
Sbjct: 1614 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1672
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
+R ++ K EE+ + EL EQE K + + +A + E+ RL E E+ +
Sbjct: 1673 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1730
Query: 448 QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
Q+RQL + E L A KR+ L ++ S A A R
Sbjct: 1731 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1783
Score = 49.7 bits (117), Expect = 7e-06
Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)
Query: 38 QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
QR E +EL + +AEE + +L + + Q+ + E G
Sbjct: 1791 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1847
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
E T L+T+ E+ K+K+ + L+ L E Q + L E DI+
Sbjct: 1848 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1896
Query: 149 SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
E L Q R+ + E + E+ + +RQ+ EE SFE+ + E
Sbjct: 1897 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1947
Query: 209 CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
L LE N + Q E++ ++ + + RE +R+Q EEE
Sbjct: 1948 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2006
Query: 257 -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
R+A + KAKV +A +L +R E+ + ++ EA + L ++E+
Sbjct: 2007 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2057
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
AFA E + LQ + + +L+ E + + EE ++ ER+A+
Sbjct: 2058 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2111
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
R L + +++A+ + E+L+ EQE ++ + A
Sbjct: 2112 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2168
Query: 436 WEMHRLEKERAKQERQLKNKKQTETEM 462
EM EK + E+ L+ K Q E E+
Sbjct: 2169 AEM---EKHKKFAEQTLRQKAQVEQEL 2192
Score = 38.9 bits (89), Expect = 0.013
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
M R++ AEE +K + E +L RTE+ K + + L++ +
Sbjct: 2396 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2444
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ ERL ++I+ ++E L + E +LQL+ + E+ Q+++
Sbjct: 2445 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2488
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
QE + LQ+ + L I+ LE+L Q LRE + ++++
Sbjct: 2489 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2547
Query: 177 IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
+++++ MEE + R E E + Q+ L+QLE Q+ Q E
Sbjct: 2548 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2588
Query: 237 EGLRTQIRELWDRLQIPEEEREA 259
E L + + L ++LQ+ EE+ A
Sbjct: 2589 ELLAEENQRLREQLQLLEEQHRA 2611
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 59.3 bits (142), Expect = 9e-09
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)
Query: 38 QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
+ E +K+ +E + +A +E+ + R + + Q+ L ++ E Q E T L
Sbjct: 2268 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2325
Query: 98 QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
+ E EL+++QK+ +++ + LQE +++ + L EE F+
Sbjct: 2326 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2365
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + R+ + E +K ++ M + +R +E L +AT
Sbjct: 2366 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2424
Query: 218 LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
+K L++ LE+Q+ Q++ E LR I EL E E+E + + K L
Sbjct: 2425 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2469
Query: 276 QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
QL+ + ++ ++ + + + +A++ + D S QR+ F E L QL
Sbjct: 2470 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2521
Query: 336 AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
E+ + + E + + Q +E RL E R+ + R L++ E+Q
Sbjct: 2522 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2579
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKA 420
R + +++L + + L+ +++L E++H A
Sbjct: 2580 RRQQEELLAEENQRLREQLQLLEEQHRAA 2608
Score = 52.4 bits (124), Expect = 1e-06
Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
EL TL S+ +++ E T+ ++E++ R E R +++ER E++ E+ ++L E
Sbjct: 1325 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1378
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
H + + +EL Q Q RE A ++ KR I +++L + +
Sbjct: 1379 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1431
Query: 195 SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
ER + +E+ + L+ AT L+ + E QK Q
Sbjct: 1432 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1491
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
+ E LR Q+++ R + E E + + + + ++ALQ LE RL+ + +
Sbjct: 1492 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1551
Query: 291 KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
+ E R VQ + Q +R +FA A+ E LQ + +L+
Sbjct: 1552 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1609
Query: 345 YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
E +E +++W+ E RL L+ E A + KEE
Sbjct: 1610 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1668
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
+R ++ K EE+ + EL EQE K + + +A + E+ RL E E+ +
Sbjct: 1669 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1726
Query: 448 QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
Q+RQL + E L A KR+ L ++ S A A R
Sbjct: 1727 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1779
Score = 49.7 bits (117), Expect = 7e-06
Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)
Query: 38 QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
QR E +EL + +AEE + +L + + Q+ + E G
Sbjct: 1787 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1843
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
E T L+T+ E+ K+K+ + L+ L E Q + L E DI+
Sbjct: 1844 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1892
Query: 149 SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
E L Q R+ + E + E+ + +RQ+ EE SFE+ + E
Sbjct: 1893 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1943
Query: 209 CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
L LE N + Q E++ ++ + + RE +R+Q EEE
Sbjct: 1944 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2002
Query: 257 -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
R+A + KAKV +A +L +R E+ + ++ EA + L ++E+
Sbjct: 2003 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2053
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
AFA E + LQ + + +L+ E + + EE ++ ER+A+
Sbjct: 2054 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2107
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
R L + +++A+ + E+L+ EQE ++ + A
Sbjct: 2108 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2164
Query: 436 WEMHRLEKERAKQERQLKNKKQTETEM 462
EM EK + E+ L+ K Q E E+
Sbjct: 2165 AEM---EKHKKFAEQTLRQKAQVEQEL 2188
Score = 38.9 bits (89), Expect = 0.013
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
M R++ AEE +K + E +L RTE+ K + + L++ +
Sbjct: 2392 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2440
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ ERL ++I+ ++E L + E +LQL+ + E+ Q+++
Sbjct: 2441 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2484
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
QE + LQ+ + L I+ LE+L Q LRE + ++++
Sbjct: 2485 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2543
Query: 177 IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
+++++ MEE + R E E + Q+ L+QLE Q+ Q E
Sbjct: 2544 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2584
Query: 237 EGLRTQIRELWDRLQIPEEEREA 259
E L + + L ++LQ+ EE+ A
Sbjct: 2585 ELLAEENQRLREQLQLLEEQHRA 2607
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 59.3 bits (142), Expect = 9e-09
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)
Query: 38 QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
+ E +K+ +E + +A +E+ + R + + Q+ L ++ E Q E T L
Sbjct: 2236 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2293
Query: 98 QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
+ E EL+++QK+ +++ + LQE +++ + L EE F+
Sbjct: 2294 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2333
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + R+ + E +K ++ M + +R +E L +AT
Sbjct: 2334 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2392
Query: 218 LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
+K L++ LE+Q+ Q++ E LR I EL E E+E + + K L
Sbjct: 2393 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2437
Query: 276 QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
QL+ + ++ ++ + + + +A++ + D S QR+ F E L QL
Sbjct: 2438 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2489
Query: 336 AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
E+ + + E + + Q +E RL E R+ + R L++ E+Q
Sbjct: 2490 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2547
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKA 420
R + +++L + + L+ +++L E++H A
Sbjct: 2548 RRQQEELLAEENQRLREQLQLLEEQHRAA 2576
Score = 52.4 bits (124), Expect = 1e-06
Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
EL TL S+ +++ E T+ ++E++ R E R +++ER E++ E+ ++L E
Sbjct: 1293 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1346
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
H + + +EL Q Q RE A ++ KR I +++L + +
Sbjct: 1347 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1399
Query: 195 SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
ER + +E+ + L+ AT L+ + E QK Q
Sbjct: 1400 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1459
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
+ E LR Q+++ R + E E + + + + ++ALQ LE RL+ + +
Sbjct: 1460 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1519
Query: 291 KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
+ E R VQ + Q +R +FA A+ E LQ + +L+
Sbjct: 1520 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1577
Query: 345 YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
E +E +++W+ E RL L+ E A + KEE
Sbjct: 1578 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1636
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
+R ++ K EE+ + EL EQE K + + +A + E+ RL E E+ +
Sbjct: 1637 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1694
Query: 448 QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
Q+RQL + E L A KR+ L ++ S A A R
Sbjct: 1695 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1747
Score = 49.7 bits (117), Expect = 7e-06
Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)
Query: 38 QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
QR E +EL + +AEE + +L + + Q+ + E G
Sbjct: 1755 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1811
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
E T L+T+ E+ K+K+ + L+ L E Q + L E DI+
Sbjct: 1812 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1860
Query: 149 SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
E L Q R+ + E + E+ + +RQ+ EE SFE+ + E
Sbjct: 1861 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1911
Query: 209 CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
L LE N + Q E++ ++ + + RE +R+Q EEE
Sbjct: 1912 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1970
Query: 257 -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
R+A + KAKV +A +L +R E+ + ++ EA + L ++E+
Sbjct: 1971 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2021
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
AFA E + LQ + + +L+ E + + EE ++ ER+A+
Sbjct: 2022 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2075
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
R L + +++A+ + E+L+ EQE ++ + A
Sbjct: 2076 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2132
Query: 436 WEMHRLEKERAKQERQLKNKKQTETEM 462
EM EK + E+ L+ K Q E E+
Sbjct: 2133 AEM---EKHKKFAEQTLRQKAQVEQEL 2156
Score = 38.9 bits (89), Expect = 0.013
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
M R++ AEE +K + E +L RTE+ K + + L++ +
Sbjct: 2360 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2408
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ ERL ++I+ ++E L + E +LQL+ + E+ Q+++
Sbjct: 2409 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2452
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
QE + LQ+ + L I+ LE+L Q LRE + ++++
Sbjct: 2453 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2511
Query: 177 IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
+++++ MEE + R E E + Q+ L+QLE Q+ Q E
Sbjct: 2512 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2552
Query: 237 EGLRTQIRELWDRLQIPEEEREA 259
E L + + L ++LQ+ EE+ A
Sbjct: 2553 ELLAEENQRLREQLQLLEEQHRA 2575
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 59.3 bits (142), Expect = 9e-09
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)
Query: 38 QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
+ E +K+ +E + +A +E+ + R + + Q+ L ++ E Q E T L
Sbjct: 2405 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2462
Query: 98 QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
+ E EL+++QK+ +++ + LQE +++ + L EE F+
Sbjct: 2463 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2502
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + R+ + E +K ++ M + +R +E L +AT
Sbjct: 2503 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2561
Query: 218 LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
+K L++ LE+Q+ Q++ E LR I EL E E+E + + K L
Sbjct: 2562 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2606
Query: 276 QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
QL+ + ++ ++ + + + +A++ + D S QR+ F E L QL
Sbjct: 2607 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2658
Query: 336 AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
E+ + + E + + Q +E RL E R+ + R L++ E+Q
Sbjct: 2659 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2716
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKA 420
R + +++L + + L+ +++L E++H A
Sbjct: 2717 RRQQEELLAEENQRLREQLQLLEEQHRAA 2745
Score = 52.4 bits (124), Expect = 1e-06
Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
EL TL S+ +++ E T+ ++E++ R E R +++ER E++ E+ ++L E
Sbjct: 1462 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1515
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
H + + +EL Q Q RE A ++ KR I +++L + +
Sbjct: 1516 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1568
Query: 195 SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
ER + +E+ + L+ AT L+ + E QK Q
Sbjct: 1569 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1628
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
+ E LR Q+++ R + E E + + + + ++ALQ LE RL+ + +
Sbjct: 1629 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1688
Query: 291 KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
+ E R VQ + Q +R +FA A+ E LQ + +L+
Sbjct: 1689 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1746
Query: 345 YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
E +E +++W+ E RL L+ E A + KEE
Sbjct: 1747 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1805
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
+R ++ K EE+ + EL EQE K + + +A + E+ RL E E+ +
Sbjct: 1806 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1863
Query: 448 QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
Q+RQL + E L A KR+ L ++ S A A R
Sbjct: 1864 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1916
Score = 49.7 bits (117), Expect = 7e-06
Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)
Query: 38 QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
QR E +EL + +AEE + +L + + Q+ + E G
Sbjct: 1924 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1980
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
E T L+T+ E+ K+K+ + L+ L E Q + L E DI+
Sbjct: 1981 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 2029
Query: 149 SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
E L Q R+ + E + E+ + +RQ+ EE SFE+ + E
Sbjct: 2030 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 2080
Query: 209 CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
L LE N + Q E++ ++ + + RE +R+Q EEE
Sbjct: 2081 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2139
Query: 257 -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
R+A + KAKV +A +L +R E+ + ++ EA + L ++E+
Sbjct: 2140 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2190
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
AFA E + LQ + + +L+ E + + EE ++ ER+A+
Sbjct: 2191 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2244
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
R L + +++A+ + E+L+ EQE ++ + A
Sbjct: 2245 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2301
Query: 436 WEMHRLEKERAKQERQLKNKKQTETEM 462
EM EK + E+ L+ K Q E E+
Sbjct: 2302 AEM---EKHKKFAEQTLRQKAQVEQEL 2325
Score = 38.9 bits (89), Expect = 0.013
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
M R++ AEE +K + E +L RTE+ K + + L++ +
Sbjct: 2529 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2577
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ ERL ++I+ ++E L + E +LQL+ + E+ Q+++
Sbjct: 2578 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2621
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
QE + LQ+ + L I+ LE+L Q LRE + ++++
Sbjct: 2622 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2680
Query: 177 IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
+++++ MEE + R E E + Q+ L+QLE Q+ Q E
Sbjct: 2681 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2721
Query: 237 EGLRTQIRELWDRLQIPEEEREA 259
E L + + L ++LQ+ EE+ A
Sbjct: 2722 ELLAEENQRLREQLQLLEEQHRA 2744
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 59.3 bits (142), Expect = 9e-09
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)
Query: 38 QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
+ E +K+ +E + +A +E+ + R + + Q+ L ++ E Q E T L
Sbjct: 2246 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2303
Query: 98 QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
+ E EL+++QK+ +++ + LQE +++ + L EE F+
Sbjct: 2304 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2343
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + R+ + E +K ++ M + +R +E L +AT
Sbjct: 2344 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2402
Query: 218 LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
+K L++ LE+Q+ Q++ E LR I EL E E+E + + K L
Sbjct: 2403 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2447
Query: 276 QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
QL+ + ++ ++ + + + +A++ + D S QR+ F E L QL
Sbjct: 2448 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2499
Query: 336 AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
E+ + + E + + Q +E RL E R+ + R L++ E+Q
Sbjct: 2500 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2557
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKA 420
R + +++L + + L+ +++L E++H A
Sbjct: 2558 RRQQEELLAEENQRLREQLQLLEEQHRAA 2586
Score = 52.4 bits (124), Expect = 1e-06
Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
EL TL S+ +++ E T+ ++E++ R E R +++ER E++ E+ ++L E
Sbjct: 1303 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1356
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
H + + +EL Q Q RE A ++ KR I +++L + +
Sbjct: 1357 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1409
Query: 195 SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
ER + +E+ + L+ AT L+ + E QK Q
Sbjct: 1410 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1469
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
+ E LR Q+++ R + E E + + + + ++ALQ LE RL+ + +
Sbjct: 1470 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1529
Query: 291 KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
+ E R VQ + Q +R +FA A+ E LQ + +L+
Sbjct: 1530 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1587
Query: 345 YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
E +E +++W+ E RL L+ E A + KEE
Sbjct: 1588 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1646
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
+R ++ K EE+ + EL EQE K + + +A + E+ RL E E+ +
Sbjct: 1647 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1704
Query: 448 QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
Q+RQL + E L A KR+ L ++ S A A R
Sbjct: 1705 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1757
Score = 49.7 bits (117), Expect = 7e-06
Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)
Query: 38 QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
QR E +EL + +AEE + +L + + Q+ + E G
Sbjct: 1765 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1821
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
E T L+T+ E+ K+K+ + L+ L E Q + L E DI+
Sbjct: 1822 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1870
Query: 149 SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
E L Q R+ + E + E+ + +RQ+ EE SFE+ + E
Sbjct: 1871 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1921
Query: 209 CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
L LE N + Q E++ ++ + + RE +R+Q EEE
Sbjct: 1922 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1980
Query: 257 -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
R+A + KAKV +A +L +R E+ + ++ EA + L ++E+
Sbjct: 1981 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2031
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
AFA E + LQ + + +L+ E + + EE ++ ER+A+
Sbjct: 2032 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2085
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
R L + +++A+ + E+L+ EQE ++ + A
Sbjct: 2086 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2142
Query: 436 WEMHRLEKERAKQERQLKNKKQTETEM 462
EM EK + E+ L+ K Q E E+
Sbjct: 2143 AEM---EKHKKFAEQTLRQKAQVEQEL 2166
Score = 38.9 bits (89), Expect = 0.013
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
M R++ AEE +K + E +L RTE+ K + + L++ +
Sbjct: 2370 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2418
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ ERL ++I+ ++E L + E +LQL+ + E+ Q+++
Sbjct: 2419 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2462
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
QE + LQ+ + L I+ LE+L Q LRE + ++++
Sbjct: 2463 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2521
Query: 177 IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
+++++ MEE + R E E + Q+ L+QLE Q+ Q E
Sbjct: 2522 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2562
Query: 237 EGLRTQIRELWDRLQIPEEEREA 259
E L + + L ++LQ+ EE+ A
Sbjct: 2563 ELLAEENQRLREQLQLLEEQHRA 2585
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 59.3 bits (142), Expect = 9e-09
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)
Query: 38 QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
+ E +K+ +E + +A +E+ + R + + Q+ L ++ E Q E T L
Sbjct: 2254 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2311
Query: 98 QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
+ E EL+++QK+ +++ + LQE +++ + L EE F+
Sbjct: 2312 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2351
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + R+ + E +K ++ M + +R +E L +AT
Sbjct: 2352 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2410
Query: 218 LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
+K L++ LE+Q+ Q++ E LR I EL E E+E + + K L
Sbjct: 2411 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2455
Query: 276 QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
QL+ + ++ ++ + + + +A++ + D S QR+ F E L QL
Sbjct: 2456 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2507
Query: 336 AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
E+ + + E + + Q +E RL E R+ + R L++ E+Q
Sbjct: 2508 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2565
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKA 420
R + +++L + + L+ +++L E++H A
Sbjct: 2566 RRQQEELLAEENQRLREQLQLLEEQHRAA 2594
Score = 52.4 bits (124), Expect = 1e-06
Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
EL TL S+ +++ E T+ ++E++ R E R +++ER E++ E+ ++L E
Sbjct: 1311 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1364
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
H + + +EL Q Q RE A ++ KR I +++L + +
Sbjct: 1365 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1417
Query: 195 SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
ER + +E+ + L+ AT L+ + E QK Q
Sbjct: 1418 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1477
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
+ E LR Q+++ R + E E + + + + ++ALQ LE RL+ + +
Sbjct: 1478 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1537
Query: 291 KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
+ E R VQ + Q +R +FA A+ E LQ + +L+
Sbjct: 1538 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1595
Query: 345 YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
E +E +++W+ E RL L+ E A + KEE
Sbjct: 1596 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1654
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
+R ++ K EE+ + EL EQE K + + +A + E+ RL E E+ +
Sbjct: 1655 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1712
Query: 448 QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
Q+RQL + E L A KR+ L ++ S A A R
Sbjct: 1713 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1765
Score = 49.7 bits (117), Expect = 7e-06
Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)
Query: 38 QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
QR E +EL + +AEE + +L + + Q+ + E G
Sbjct: 1773 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1829
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
E T L+T+ E+ K+K+ + L+ L E Q + L E DI+
Sbjct: 1830 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1878
Query: 149 SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
E L Q R+ + E + E+ + +RQ+ EE SFE+ + E
Sbjct: 1879 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1929
Query: 209 CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
L LE N + Q E++ ++ + + RE +R+Q EEE
Sbjct: 1930 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 1988
Query: 257 -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
R+A + KAKV +A +L +R E+ + ++ EA + L ++E+
Sbjct: 1989 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2039
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
AFA E + LQ + + +L+ E + + EE ++ ER+A+
Sbjct: 2040 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2093
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
R L + +++A+ + E+L+ EQE ++ + A
Sbjct: 2094 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2150
Query: 436 WEMHRLEKERAKQERQLKNKKQTETEM 462
EM EK + E+ L+ K Q E E+
Sbjct: 2151 AEM---EKHKKFAEQTLRQKAQVEQEL 2174
Score = 38.9 bits (89), Expect = 0.013
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
M R++ AEE +K + E +L RTE+ K + + L++ +
Sbjct: 2378 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2426
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ ERL ++I+ ++E L + E +LQL+ + E+ Q+++
Sbjct: 2427 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2470
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
QE + LQ+ + L I+ LE+L Q LRE + ++++
Sbjct: 2471 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2529
Query: 177 IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
+++++ MEE + R E E + Q+ L+QLE Q+ Q E
Sbjct: 2530 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2570
Query: 237 EGLRTQIRELWDRLQIPEEEREA 259
E L + + L ++LQ+ EE+ A
Sbjct: 2571 ELLAEENQRLREQLQLLEEQHRA 2593
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 59.3 bits (142), Expect = 9e-09
Identities = 82/389 (21%), Positives = 168/389 (43%), Gaps = 54/389 (13%)
Query: 38 QRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTIL 97
+ E +K+ +E + +A +E+ + R + + Q+ L ++ E Q E T L
Sbjct: 2295 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQR--ALAEKMLKEKMQAVQEATRL 2352
Query: 98 QLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR 157
+ E EL+++QK+ +++ + LQE +++ + L EE F+
Sbjct: 2353 KAE------AELLQQQKELAQEQARRLQEDKEQMAQQLA--------------EETQGFQ 2392
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + R+ + E +K ++ M + +R +E L +AT
Sbjct: 2393 RTLEAERQRQLEMSAEAERLKLRVAE-MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAT 2451
Query: 218 LQK--LLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKAL 275
+K L++ LE+Q+ Q++ E LR I EL E E+E + + K L
Sbjct: 2452 QEKVTLVQTLEIQRQQSDHDAERLREAIAEL-------EREKEKL--------QQEAKLL 2496
Query: 276 QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHD 335
QL+ + ++ ++ + + + +A++ + D S QR+ F E L QL
Sbjct: 2497 QLKSEEMQTVQQEQLLQETQALQQSFLSEKD----SLLQRERF----IEQEKAKLEQLFQ 2548
Query: 336 AEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE---RKASDPNRFTNRGGNLLKE-EKQ 391
E+ + + E + + Q +E RL E R+ + R L++ E+Q
Sbjct: 2549 DEVAKAQQLREEQQR--QQQQMEQERQRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ 2606
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKA 420
R + +++L + + L+ +++L E++H A
Sbjct: 2607 RRQQEELLAEENQRLREQLQLLEEQHRAA 2635
Score = 52.4 bits (124), Expect = 1e-06
Identities = 109/476 (22%), Positives = 189/476 (39%), Gaps = 68/476 (14%)
Query: 75 ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
EL TL S+ +++ E T+ ++E++ R E R +++ER E++ E+ ++L E
Sbjct: 1352 ELTTLTSQ-YIKFISE----TLRRMEEEERL-AEQQRAEERERLAEVEAALEKQRQLAEA 1405
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
H + + +EL Q Q RE A ++ KR I +++L + +
Sbjct: 1406 ----HAQAKAQAEREAKELQQRMQEEVVRREEAAVDAQQQ---KRSIQEELQQLRQSSEA 1458
Query: 195 SF----------ERDVVCEDEDAFCLSLENIAT-------------LQKLLRQLEMQKSQ 231
ER + +E+ + L+ AT L+ + E QK Q
Sbjct: 1459 EIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQ 1518
Query: 232 NEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQNM 290
+ E LR Q+++ R + E E + + + + ++ALQ LE RL+ + +
Sbjct: 1519 AQEEAERLRRQVQDESQRKRQAEVELASRVKAEAEAAREKQRALQALEELRLQAEEAERR 1578
Query: 291 KKVIEAIRVELVQYWDQCFYS------QEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
+ E R VQ + Q +R +FA A+ E LQ + +L+
Sbjct: 1579 LRQAEVERARQVQVALETAQRSAEAELQSKRASFAEKTAQ--LERSLQEEHVAVAQLREE 1636
Query: 345 YE-----------VHKELFEGVQKWE----ETWRLFLEFERKASDPNRFTNRGGNLLKEE 389
E +E +++W+ E RL L+ E A + KEE
Sbjct: 1637 AERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS-LAQAEAEKQKEE 1695
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRL--EKERAK 447
+R ++ K EE+ + EL EQE K + + +A + E+ RL E E+ +
Sbjct: 1696 AEREARRR--GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1753
Query: 448 QERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTMSNATANSSIR 503
Q+RQL + E L A KR+ L ++ S A A R
Sbjct: 1754 QQRQL---LEEELARLQREAAAATQKRQELEAELAKVRAEMEVLLASKARAEEESR 1806
Score = 49.7 bits (117), Expect = 7e-06
Identities = 100/447 (22%), Positives = 175/447 (39%), Gaps = 67/447 (14%)
Query: 38 QRTEVVKKHIKELLD-----MMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
QR E +EL + +AEE + +L + + Q+ + E G
Sbjct: 1814 QRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR---AEAERVLAEKLAAIG 1870
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQE----QDQELCEILCMPHYDIDSASVP 148
E T L+T+ E+ K+K+ + L+ L E Q + L E DI+
Sbjct: 1871 EAT------RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIE----- 1919
Query: 149 SLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAF 208
E L Q R+ + E + E+ + +RQ+ EE SFE+ + E
Sbjct: 1920 --ERLAQLRKASDSELERQKGLVEDTLRQRRQV----EEEILALKASFEKAAAGKAE--- 1970
Query: 209 CLSLE------NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQ---IPEEE--- 256
L LE N + Q E++ ++ + + RE +R+Q EEE
Sbjct: 1971 -LELELGRIRSNAEDTLRSKEQAELEAARQRQLAAEEERRRREAEERVQKSLAAEEEAAR 2029
Query: 257 -REAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
R+A + KAKV +A +L +R E+ + ++ EA + L ++E+
Sbjct: 2030 QRKAALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRL--------QAEEKA 2080
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
AFA E + LQ + + +L+ E + + EE ++ ER+A+
Sbjct: 2081 HAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR------RAAEEAEEARVQAEREAAQS 2134
Query: 376 NRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQ 435
R L + +++A+ + E+L+ EQE ++ + A
Sbjct: 2135 RRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEA---EQEAARRAQAEQAALRQKQAAD 2191
Query: 436 WEMHRLEKERAKQERQLKNKKQTETEM 462
EM EK + E+ L+ K Q E E+
Sbjct: 2192 AEM---EKHKKFAEQTLRQKAQVEQEL 2215
Score = 38.9 bits (89), Expect = 0.013
Identities = 60/263 (22%), Positives = 111/263 (42%), Gaps = 51/263 (19%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVV---KKHIKELLDMMIAE 57
M R++ AEE +K + E +L RTE+ K + + L++ +
Sbjct: 2419 MSRAQARAEEDAQRFRKQAEEIGE-----------KLHRTELATQEKVTLVQTLEIQRQQ 2467
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ ERL ++I+ ++E L + E +LQL+ + E+ Q+++
Sbjct: 2468 SDHDAERLREAIAELEREKEKL-----------QQEAKLLQLKSE-----EMQTVQQEQL 2511
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFR-QHVTTLRETKASRREEFVS 176
QE + LQ+ + L I+ LE+L Q LRE + ++++
Sbjct: 2512 LQETQALQQSFLSEKDSLLQRERFIEQEKA-KLEQLFQDEVAKAQQLREEQQRQQQQMEQ 2570
Query: 177 IKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC 236
+++++ MEE + R E E + Q+ L+QLE Q+ Q E
Sbjct: 2571 ERQRLVASMEE-------ARRRQHEAE---------EGVRRKQEELQQLEQQRRQQE--- 2611
Query: 237 EGLRTQIRELWDRLQIPEEEREA 259
E L + + L ++LQ+ EE+ A
Sbjct: 2612 ELLAEENQRLREQLQLLEEQHRA 2634
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 58.9 bits (141), Expect = 1e-08
Identities = 105/519 (20%), Positives = 217/519 (41%), Gaps = 77/519 (14%)
Query: 19 LNHLREIWELIGIPEDQRLQRT---EVVKKH--IKELLDMMIAEEES---LKERLIKSIS 70
++ L+E ++ + +D++++ + E+ +K I+EL +I EE+ LK++L +
Sbjct: 298 ISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK 357
Query: 71 --------VCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELK 122
+ QK +L + +++ + ++++ + T EL ++ K+ + E
Sbjct: 358 LLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417
Query: 123 LLQEQDQELCEILCMPHYDIDSASVPSLEELNQ--FRQHVTTLRETKASRREEFVSIKRQ 180
++Q +QE L ++D + ++ Q RQH+ + E K + E + R
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477
Query: 181 -------------IILCMEELD-HTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLE 226
+ + + EL+ DT+ +++ + E+ L LE LQ+ L L
Sbjct: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE---LGLILEEKCALQRQLEDLV 534
Query: 227 MQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAV----ATIMSGSKAKVRKALQ------ 276
+ S + + R I E +L + V A I+S S+++ L+
Sbjct: 535 EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVT 594
Query: 277 ---LEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQL 333
++++ LE+ K + ++ E+ EL + Q +S E+ + E L
Sbjct: 595 NYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS-------KLKEDLEIE 647
Query: 334 HDAEIVRLKNYYEVH-KELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQR 392
H I +LK+ +H K+ +G+Q ++FE+ N T + +L+ K +
Sbjct: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD----NLITKQNQLILEISKLK 703
Query: 393 AKLQKMLPKLEEELKARIE--------LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKE 444
Q ++ EE+ +I L ++E K + + ++ E E EKE
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKE 763
Query: 445 RAKQER---------QLKNKKQTETEMLYGSAPRTPSKR 474
QE+ LK++K+T +ML P + +R
Sbjct: 764 NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEER 802
Score = 46.2 bits (108), Expect = 8e-05
Identities = 60/282 (21%), Positives = 129/282 (45%), Gaps = 36/282 (12%)
Query: 36 RLQRTEVVKKHIKELLDMMIAEEESLK-------ERLIKSISVCQKELNTLCSELHVEPF 88
RLQ E ++ I+E +++ ++E++K ++L++ KE L + E
Sbjct: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE--KLEVQCQAEKV 2015
Query: 89 QEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVP 148
+++ + + LE D+ QV + ++E+ EL L++Q+Q L + L +D ++
Sbjct: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
Query: 149 SLEELNQFRQHVTTL-RETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDA 207
E + F+Q + L ++ K R + +S + E++ + E+ C
Sbjct: 2076 REHERDVFQQEIQKLEQQLKVVPRFQPISEHQ-----TREVEQLANHLKEKTDKCS---- 2126
Query: 208 FCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPE------EEREAVA 261
E + + ++L R ++ +NE + E L ++REL L + E+R+
Sbjct: 2127 -----ELLLSKEQLQRDIQ---ERNEEI-EKLEFRVRELEQALLVSADTFQKVEDRKHFG 2177
Query: 262 TIMSGSKAKVRKALQLEVDRLE--ELKMQNMKKVIEAIRVEL 301
+ + + + LQ E D ++ E ++ N+++ +E R EL
Sbjct: 2178 AVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2219
Score = 45.4 bits (106), Expect = 1e-04
Identities = 101/473 (21%), Positives = 204/473 (43%), Gaps = 85/473 (17%)
Query: 30 GIPEDQRLQRTEVVKKHI----KELLDMMIAEEESLKERLIKSISVCQKELN---TLCSE 82
G QRL R+ I +EL+ + + ++ E+L+++IS +L +E
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
Query: 83 LHVEPFQEEGETT-ILQLEKDLRTQVELMRKQKKERKQELK--------------LLQEQ 127
L E F+++ E T L+ +++LR ++ + +++ EL L + Q
Sbjct: 1878 LMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQ 1937
Query: 128 DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRRE----EFVSIKRQIIL 183
QE +I+ ++ AS L+EL +Q + RE + ++E E +++Q++
Sbjct: 1938 IQEKTDIIDRLEQELLCAS-NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
Query: 184 CMEEL-DHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQ 242
E+L + + + V +D +LE I +++ R +E+++ +N T+
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALE-IDVEEQVSRFIELEQEKN--------TE 2047
Query: 243 IRELWDRLQIPEEEREAVATIMSGS---KAKVRKALQLEVDRLEE-LKM--------QNM 290
+ +L + Q E++ E + + + R Q E+ +LE+ LK+ ++
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 291 KKVIEAIRVELVQYWDQC---FYSQEQRQAFAPFCAEDYTE---SLLQLHDAEIVRLKNY 344
+ +E + L + D+C S+EQ Q E+ + + +L A +V +
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTF 2167
Query: 345 YEVH-KELFEGVQ-KWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKL 402
+V ++ F V+ K E + + L+ ER A D ++EK+ L++ L +
Sbjct: 2168 QKVEDRKHFGAVEAKPELSLEVQLQAERDAID------------RKEKEITNLEEQLEQF 2215
Query: 403 EEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNK 455
EEL+ + E +Q H Q E+ + E QE + +NK
Sbjct: 2216 REELENKNEEVQQLHM----------------QLEIQKKESTTRLQELEQENK 2252
Score = 45.1 bits (105), Expect = 2e-04
Identities = 92/465 (19%), Positives = 181/465 (38%), Gaps = 77/465 (16%)
Query: 4 SEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKE 63
SEV ++ K N LRE E G+ + Q + H++ + + ++ ++E
Sbjct: 116 SEVNGCSFVMRTGKPTNLLRE--EEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEE 173
Query: 64 RLIKSISVCQKELNTLCSELHVEPFQE--EGETTILQLE---KDLRTQVELMRKQKKERK 118
+EL + E Q+ E E I Q + L ++ R++K E
Sbjct: 174 --------LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETM 225
Query: 119 QELKLLQEQDQEL---CEILCMPHYDIDSASVPSLEELNQFRQHVTT----------LRE 165
+E L EQ Q+L + L +S + +L Q +Q + T L E
Sbjct: 226 REFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE 285
Query: 166 TKASRREEFVS----IKRQIILCMEELDHTPDTSFERDV-------------VCEDEDAF 208
++E+F ++ +I + E D + S + ++ + E+E
Sbjct: 286 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKT 345
Query: 209 CLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSK 268
+ + T KLL +L+ Q Q + ++ ++ + + EE + + + +
Sbjct: 346 LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405
Query: 269 AKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTE 328
+ K Q E D ++ ++ + +K +E +R EL + + Q +Q
Sbjct: 406 KRNHKDSQFETDIVQRMEQETQRK-LEQLRAELDEMYGQQIVQMKQ-------------- 450
Query: 329 SLLQLHDAEIVRLKNYYEVHKE----LFEGVQKWEETWRLFLEFERKASDPNRFTNRGGN 384
L++ H A++ +K ++ E + + E+ +L + + + TN
Sbjct: 451 ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
Query: 385 LLKEE-----KQRAKLQKMLPKLEEEL--------KARIELWEQE 416
LKEE +++ LQ+ L L EEL +AR + EQE
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE 555
Score = 41.6 bits (96), Expect = 0.002
Identities = 77/379 (20%), Positives = 155/379 (40%), Gaps = 64/379 (16%)
Query: 101 KDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLE---ELNQFR 157
+ L ++++ + Q RK LK QE ++ E+L Y+I LE EL+ +
Sbjct: 3088 RSLLSEIQALHAQMNGRKITLKREQESEKPSQELL---EYNIQQKQSQMLEMQVELSSMK 3144
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELD--------HTPDTSFERDVVCEDEDAFC 209
T L+E +S + +K ++ EL+ H + R V + D
Sbjct: 3145 DRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVH 3204
Query: 210 LSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKA 269
L + +A+ QK R+L+ + +A + E ++E + + ++
Sbjct: 3205 LLNDTLASEQKKSRELQWALEKEKAKLG-------------RSEERDKEELEDLKFSLES 3251
Query: 270 KVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTES 329
+ ++ LQL + L E + Q + + + I + + Y Q S+EQ + +
Sbjct: 3252 QKQRNLQLNL--LLEQQKQLLNESQQKIESQRMLYDAQL--SEEQGRNLE-------LQV 3300
Query: 330 LLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKE- 388
LL+ I + + + +EL +Q + T + +R +LLKE
Sbjct: 3301 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ------------SRPPLPSEDLLKEL 3348
Query: 389 ----EKQRAKLQKMLPKLEE------ELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEM 438
E++ +++ ++L + E+ + + ++E Q H K + E Q +M
Sbjct: 3349 QKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTE---GQKKM 3405
Query: 439 HRLEKERAKQERQLKNKKQ 457
H L+ + +RQL+ K+Q
Sbjct: 3406 HELQSKVEDLQRQLEEKRQ 3424
Score = 40.8 bits (94), Expect = 0.003
Identities = 85/396 (21%), Positives = 161/396 (40%), Gaps = 68/396 (17%)
Query: 85 VEPFQEEGETTILQLEKDLRTQVELMR---KQKKERKQELKLLQEQDQELCEILCMPHYD 141
VE E T QLE TQ ELMR +QK+E + LK +E + L E +
Sbjct: 1854 VEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEE--SRARE 1911
Query: 142 IDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILC----MEELD-HTPDTSF 196
+ + E + TL E + + + + Q +LC ++EL+
Sbjct: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
Query: 197 ERDVVCEDEDAFCLSLENIATLQKLLRQLE-MQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
ER+++ ++A + E Q+LL++ E + K + E C+
Sbjct: 1972 ERELLSRQKEA--MKAEAGPVEQQLLQETEKLMKEKLEVQCQA----------------- 2012
Query: 256 EREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
KVR LQ +V LE + + + IE + + + D ++Q
Sbjct: 2013 -------------EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD----LRQQN 2055
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
QA E E + + D + + ++ +V + + +QK E+ ++ F+ +
Sbjct: 2056 QAL-----EKQLEKMRKFLDEQAIDREHERDVFQ---QEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 376 NRFTNRGGNLLKEEKQRA--------KLQKMLPKLEEELKARIELWEQEHSKAFMVNGQK 427
R + N LKE+ + +LQ+ + + EE++ ++E +E +A +V+
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE-KLEFRVRELEQALLVSADT 2166
Query: 428 FMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEML 463
F + V ++ +E AK E L+ + Q E + +
Sbjct: 2167 FQK-VEDRKHFGAVE---AKPELSLEVQLQAERDAI 2198
Score = 39.3 bits (90), Expect = 0.010
Identities = 104/467 (22%), Positives = 187/467 (40%), Gaps = 81/467 (17%)
Query: 54 MIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVE-LMRK 112
+I E+E ++L + ++ Q++L +E E L +DL TQ+E LM
Sbjct: 2286 IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE--------LIRDLETQIECLMSD 2337
Query: 113 Q---KKERKQELKLLQEQ----DQELCEILCMPHYDIDSASVPS----------LEELNQ 155
Q K+ R++E++ L E QEL I + S S + + E
Sbjct: 2338 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2397
Query: 156 FRQHVTT-----------LRETKASRR---EEFVSIKRQIILCMEELDHTPDTSFE--RD 199
Q V T L+ET +E S+KR+ +E++ P+ S D
Sbjct: 2398 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAID 2456
Query: 200 VVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREA 259
+ +D+ + L A L+ L Q + + + + R L +L+ ++
Sbjct: 2457 HLSKDKPELEVVLTEDA-LKSLENQTYFKSFEENGKGSIINLETRLL--QLESTVSAKDL 2513
Query: 260 VATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVI-EAIRVELVQYWDQCFYSQEQRQAF 318
T +++ Q E + L++ K+ N++K++ E + LV E Q +
Sbjct: 2514 ELTQCYKQIKDMQEQGQFETEMLQK-KIVNLQKIVEEKVAAALVSQ-----IQLEAVQEY 2567
Query: 319 APFCAEDYT----------ESLLQLHDAEI--------VRL----KNYYEVHKELFEGVQ 356
A FC ++ T ++L QL + E+ +R+ E+H L +
Sbjct: 2568 AKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE 2627
Query: 357 KWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQE 416
+ E + LE E+K + + GN E+KQR K +K P+ E LK EL+
Sbjct: 2628 QVEIAEKNVLEKEKKLLELQKLLE--GN---EKKQREKEKKRSPQDVEVLKTTTELFHSN 2682
Query: 417 HSKAFMVNGQKF-MEYVAEQWEMHRLEKERAKQERQLKNKKQTETEM 462
F + E VA + E+ +++ K + +L K+ T +
Sbjct: 2683 EESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSL 2729
Score = 37.4 bits (85), Expect = 0.037
Identities = 63/320 (19%), Positives = 134/320 (41%), Gaps = 26/320 (8%)
Query: 20 NHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTL 79
N + + E + +D + + + I +L D+ + S E + I+ QKE+ L
Sbjct: 672 NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEIL 731
Query: 80 CSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELK-----------LLQEQD 128
E E+ + T+ Q ++L+ + EL+ KQ KE++ +L+ +L+++
Sbjct: 732 RQE-------EKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
Query: 129 QELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEEL 188
+ L ++L + + L+ + + +E + EE +K+Q I EE+
Sbjct: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI-LIEENEDLKQQCIQLNEEI 843
Query: 189 DHTPDT-SF-ERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIREL 246
+ +T SF E++ ++ E A L K+ LE K++ E + + E
Sbjct: 844 EKQRNTFSFAEKNFEVNYQEL----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE 899
Query: 247 WDRLQIPEEEREAVATIMSGSKAKVRKALQL-EVDRLEELKMQNMKKVIEAIRVELVQYW 305
+I + +++ K V + L++ EV + ++ +V + ++EL Q
Sbjct: 900 LHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRL 959
Query: 306 DQCFYSQEQRQAFAPFCAED 325
+Q+ F E+
Sbjct: 960 SDLSEQLKQKHGEISFLNEE 979
Score = 30.8 bits (68), Expect = 3.5
Identities = 56/276 (20%), Positives = 120/276 (43%), Gaps = 40/276 (14%)
Query: 35 QRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGET 94
+ L+ EVV+K EL++ + E + +E+L EL+ S+L + Q+ GE
Sbjct: 926 ETLEMGEVVEKDTTELMEKL---EVTKREKL---------ELSQRLSDLSEQLKQKHGEI 973
Query: 95 TILQLE-KDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEEL 153
+ L E K L+ + E + + +E + + + ++ + C+ S+ + + +
Sbjct: 974 SFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV-------SSLLDGVVTM 1026
Query: 154 NQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLE 213
+ + K+ E + ++ ++ SFE V E+ L L+
Sbjct: 1027 TSRGAEGSVSKVNKSFGEESKIMVEDKV-------------SFENMTVGEESKQEQLILD 1073
Query: 214 NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD-RLQIPEEEREAVATIMSGSKAKVR 272
++ ++ K Q S+N+ + + L E D RLQ+ E +R ++ + S +VR
Sbjct: 1074 HLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQM-EAQRICLSLVYSTHVDQVR 1132
Query: 273 KALQLEVDRL-----EELKMQNMKKVIEAIRVELVQ 303
+ ++ E D+ EEL +K+ E ++ ++
Sbjct: 1133 EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLE 1168
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 58.9 bits (141), Expect = 1e-08
Identities = 105/519 (20%), Positives = 217/519 (41%), Gaps = 77/519 (14%)
Query: 19 LNHLREIWELIGIPEDQRLQRT---EVVKKH--IKELLDMMIAEEES---LKERLIKSIS 70
++ L+E ++ + +D++++ + E+ +K I+EL +I EE+ LK++L +
Sbjct: 298 ISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKDKLTTADK 357
Query: 71 --------VCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELK 122
+ QK +L + +++ + ++++ + T EL ++ K+ + E
Sbjct: 358 LLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETD 417
Query: 123 LLQEQDQELCEILCMPHYDIDSASVPSLEELNQ--FRQHVTTLRETKASRREEFVSIKRQ 180
++Q +QE L ++D + ++ Q RQH+ + E K + E + R
Sbjct: 418 IVQRMEQETQRKLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRS 477
Query: 181 -------------IILCMEELD-HTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLE 226
+ + + EL+ DT+ +++ + E+ L LE LQ+ L L
Sbjct: 478 YSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEE---LGLILEEKCALQRQLEDLV 534
Query: 227 MQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAV----ATIMSGSKAKVRKALQ------ 276
+ S + + R I E +L + V A I+S S+++ L+
Sbjct: 535 EELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVT 594
Query: 277 ---LEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQL 333
++++ LE+ K + ++ E+ EL + Q +S E+ + E L
Sbjct: 595 NYKIKLEMLEKEKNAVLDRMAESQEAELERLRTQLLFSHEEELS-------KLKEDLEIE 647
Query: 334 HDAEIVRLKNYYEVH-KELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQR 392
H I +LK+ +H K+ +G+Q ++FE+ N T + +L+ K +
Sbjct: 648 HRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKD----NLITKQNQLILEISKLK 703
Query: 393 AKLQKMLPKLEEELKARIE--------LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKE 444
Q ++ EE+ +I L ++E K + + ++ E E EKE
Sbjct: 704 DLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKE 763
Query: 445 RAKQER---------QLKNKKQTETEMLYGSAPRTPSKR 474
QE+ LK++K+T +ML P + +R
Sbjct: 764 NDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQEER 802
Score = 48.5 bits (114), Expect = 2e-05
Identities = 60/276 (21%), Positives = 129/276 (46%), Gaps = 32/276 (11%)
Query: 36 RLQRTEVVKKHIKELLDMMIAEEESLK-------ERLIKSISVCQKELNTLCSELHVEPF 88
RLQ E ++ I+E +++ ++E++K ++L++ KE L + E
Sbjct: 1958 RLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMKE--KLEVQCQAEKV 2015
Query: 89 QEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVP 148
+++ + + LE D+ QV + ++E+ EL L++Q+Q L + L +D ++
Sbjct: 2016 RDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDEQAID 2075
Query: 149 SLEELNQFRQHVTTL-RETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDA 207
E + F+Q + L ++ K R + +S + E++ + E+ C
Sbjct: 2076 REHERDVFQQEIQKLEQQLKVVPRFQPISEHQ-----TREVEQLANHLKEKTDKCS---- 2126
Query: 208 FCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGS 267
E + + ++L R ++ +NE + E L ++REL L + E+R+ + +
Sbjct: 2127 -----ELLLSKEQLQRDIQ---ERNEEI-EKLEFRVRELEQALLV--EDRKHFGAVEAKP 2175
Query: 268 KAKVRKALQLEVDRLE--ELKMQNMKKVIEAIRVEL 301
+ + LQ E D ++ E ++ N+++ +E R EL
Sbjct: 2176 ELSLEVQLQAERDAIDRKEKEITNLEEQLEQFREEL 2211
Score = 45.1 bits (105), Expect = 2e-04
Identities = 92/465 (19%), Positives = 181/465 (38%), Gaps = 77/465 (16%)
Query: 4 SEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKE 63
SEV ++ K N LRE E G+ + Q + H++ + + ++ ++E
Sbjct: 116 SEVNGCSFVMRTGKPTNLLRE--EEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHEIEE 173
Query: 64 RLIKSISVCQKELNTLCSELHVEPFQE--EGETTILQLE---KDLRTQVELMRKQKKERK 118
+EL + E Q+ E E I Q + L ++ R++K E
Sbjct: 174 --------LNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETM 225
Query: 119 QELKLLQEQDQEL---CEILCMPHYDIDSASVPSLEELNQFRQHVTT----------LRE 165
+E L EQ Q+L + L +S + +L Q +Q + T L E
Sbjct: 226 REFLELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLE 285
Query: 166 TKASRREEFVS----IKRQIILCMEELDHTPDTSFERDV-------------VCEDEDAF 208
++E+F ++ +I + E D + S + ++ + E+E
Sbjct: 286 DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKT 345
Query: 209 CLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSK 268
+ + T KLL +L+ Q Q + ++ ++ + + EE + + + +
Sbjct: 346 LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405
Query: 269 AKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTE 328
+ K Q E D ++ ++ + +K +E +R EL + + Q +Q
Sbjct: 406 KRNHKDSQFETDIVQRMEQETQRK-LEQLRAELDEMYGQQIVQMKQ-------------- 450
Query: 329 SLLQLHDAEIVRLKNYYEVHKE----LFEGVQKWEETWRLFLEFERKASDPNRFTNRGGN 384
L++ H A++ +K ++ E + + E+ +L + + + TN
Sbjct: 451 ELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKE 510
Query: 385 LLKEE-----KQRAKLQKMLPKLEEEL--------KARIELWEQE 416
LKEE +++ LQ+ L L EEL +AR + EQE
Sbjct: 511 KLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQE 555
Score = 44.3 bits (103), Expect = 3e-04
Identities = 99/468 (21%), Positives = 197/468 (42%), Gaps = 83/468 (17%)
Query: 30 GIPEDQRLQRTEVVKKHI----KELLDMMIAEEESLKERLIKSISVCQKELN---TLCSE 82
G QRL R+ I +EL+ + + ++ E+L+++IS +L +E
Sbjct: 1818 GTELSQRLVRSGFAGTEIDPENEELMLNISSRLQAAVEKLLEAISETSSQLEHAKVTQTE 1877
Query: 83 LHVEPFQEEGETT-ILQLEKDLRTQVELMRKQKKERKQELK--------------LLQEQ 127
L E F+++ E T L+ +++LR ++ + +++ EL L + Q
Sbjct: 1878 LMRESFRQKQEATESLKCQEELRERLHEESRAREQLAVELSKAEGVIDGYADEKTLFERQ 1937
Query: 128 DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRRE----EFVSIKRQIIL 183
QE +I+ ++ AS L+EL +Q + RE + ++E E +++Q++
Sbjct: 1938 IQEKTDIIDRLEQELLCAS-NRLQELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQ 1996
Query: 184 CMEEL-DHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQ 242
E+L + + + V +D +LE I +++ R +E+++ +N T+
Sbjct: 1997 ETEKLMKEKLEVQCQAEKVRDDLQKQVKALE-IDVEEQVSRFIELEQEKN--------TE 2047
Query: 243 IRELWDRLQIPEEEREAVATIMSGS---KAKVRKALQLEVDRLEE-LKM--------QNM 290
+ +L + Q E++ E + + + R Q E+ +LE+ LK+ ++
Sbjct: 2048 LMDLRQQNQALEKQLEKMRKFLDEQAIDREHERDVFQQEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 291 KKVIEAIRVELVQYWDQC---FYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEV 347
+ +E + L + D+C S+EQ Q E+ + ++ + E L E
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEFRVRELEQALL---VED 2164
Query: 348 HKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELK 407
K K E + + L+ ER A D ++EK+ L++ L + EEL+
Sbjct: 2165 RKHFGAVEAKPELSLEVQLQAERDAID------------RKEKEITNLEEQLEQFREELE 2212
Query: 408 ARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNK 455
+ E +Q H Q E+ + E QE + +NK
Sbjct: 2213 NKNEEVQQLHM----------------QLEIQKKESTTRLQELEQENK 2244
Score = 42.0 bits (97), Expect = 0.002
Identities = 86/403 (21%), Positives = 161/403 (39%), Gaps = 77/403 (19%)
Query: 85 VEPFQEEGETTILQLEKDLRTQVELMR---KQKKERKQELKLLQEQDQELCEILCMPHYD 141
VE E T QLE TQ ELMR +QK+E + LK +E + L E +
Sbjct: 1854 VEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLHEE--SRARE 1911
Query: 142 IDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILC----MEELD-HTPDTSF 196
+ + E + TL E + + + + Q +LC ++EL+
Sbjct: 1912 QLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEAEQQQIQE 1971
Query: 197 ERDVVCEDEDAFCLSLENIATLQKLLRQLE-MQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
ER+++ ++A + E Q+LL++ E + K + E C+
Sbjct: 1972 ERELLSRQKEA--MKAEAGPVEQQLLQETEKLMKEKLEVQCQA----------------- 2012
Query: 256 EREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQR 315
KVR LQ +V LE + + + IE + + + D ++Q
Sbjct: 2013 -------------EKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMD----LRQQN 2055
Query: 316 QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDP 375
QA E E + + D + + ++ +V + + +QK E+ ++ F+ +
Sbjct: 2056 QAL-----EKQLEKMRKFLDEQAIDREHERDVFQ---QEIQKLEQQLKVVPRFQPISEHQ 2107
Query: 376 NRFTNRGGNLLKEEKQRA--------KLQKMLPKLEEELKARIELWEQEHSKAFMVNGQK 427
R + N LKE+ + +LQ+ + + EE++ ++E +E +A +V +K
Sbjct: 2108 TREVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIE-KLEFRVRELEQALLVEDRK 2166
Query: 428 F-------------MEYVAEQWEMHRLEKERAKQERQLKNKKQ 457
++ AE+ + R EKE E QL+ ++
Sbjct: 2167 HFGAVEAKPELSLEVQLQAERDAIDRKEKEITNLEEQLEQFRE 2209
Score = 41.6 bits (96), Expect = 0.002
Identities = 77/379 (20%), Positives = 155/379 (40%), Gaps = 64/379 (16%)
Query: 101 KDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLE---ELNQFR 157
+ L ++++ + Q RK LK QE ++ E+L Y+I LE EL+ +
Sbjct: 3080 RSLLSEIQALHAQMNGRKITLKREQESEKPSQELL---EYNIQQKQSQMLEMQVELSSMK 3136
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELD--------HTPDTSFERDVVCEDEDAFC 209
T L+E +S + +K ++ EL+ H + R V + D
Sbjct: 3137 DRATELQEQLSSEKMVVAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVH 3196
Query: 210 LSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKA 269
L + +A+ QK R+L+ + +A + E ++E + + ++
Sbjct: 3197 LLNDTLASEQKKSRELQWALEKEKAKLG-------------RSEERDKEELEDLKFSLES 3243
Query: 270 KVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTES 329
+ ++ LQL + L E + Q + + + I + + Y Q S+EQ + +
Sbjct: 3244 QKQRNLQLNL--LLEQQKQLLNESQQKIESQRMLYDAQL--SEEQGRNLE-------LQV 3292
Query: 330 LLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKE- 388
LL+ I + + + +EL +Q + T + +R +LLKE
Sbjct: 3293 LLESEKVRIREMSSTLDRERELHAQLQSSDGTGQ------------SRPPLPSEDLLKEL 3340
Query: 389 ----EKQRAKLQKMLPKLEE------ELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEM 438
E++ +++ ++L + E+ + + ++E Q H K + E Q +M
Sbjct: 3341 QKQLEEKHSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTE---GQKKM 3397
Query: 439 HRLEKERAKQERQLKNKKQ 457
H L+ + +RQL+ K+Q
Sbjct: 3398 HELQSKVEDLQRQLEEKRQ 3416
Score = 39.3 bits (90), Expect = 0.010
Identities = 104/467 (22%), Positives = 187/467 (40%), Gaps = 81/467 (17%)
Query: 54 MIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVE-LMRK 112
+I E+E ++L + ++ Q++L +E E L +DL TQ+E LM
Sbjct: 2278 IIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNE--------LIRDLETQIECLMSD 2329
Query: 113 Q---KKERKQELKLLQEQ----DQELCEILCMPHYDIDSASVPS----------LEELNQ 155
Q K+ R++E++ L E QEL I + S S + + E
Sbjct: 2330 QECVKRNREEEIEQLNEVIEKLQQELANIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLA 2389
Query: 156 FRQHVTT-----------LRETKASRR---EEFVSIKRQIILCMEELDHTPDTSFE--RD 199
Q V T L+ET +E S+KR+ +E++ P+ S D
Sbjct: 2390 LEQQVETANEEMTFMKNVLKETNFKMNQLTQELFSLKRE-RESVEKIQSIPENSVNVAID 2448
Query: 200 VVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREA 259
+ +D+ + L A L+ L Q + + + + R L +L+ ++
Sbjct: 2449 HLSKDKPELEVVLTEDA-LKSLENQTYFKSFEENGKGSIINLETRLL--QLESTVSAKDL 2505
Query: 260 VATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVI-EAIRVELVQYWDQCFYSQEQRQAF 318
T +++ Q E + L++ K+ N++K++ E + LV E Q +
Sbjct: 2506 ELTQCYKQIKDMQEQGQFETEMLQK-KIVNLQKIVEEKVAAALVSQ-----IQLEAVQEY 2559
Query: 319 APFCAEDYT----------ESLLQLHDAEI--------VRL----KNYYEVHKELFEGVQ 356
A FC ++ T ++L QL + E+ +R+ E+H L +
Sbjct: 2560 AKFCQDNQTISSEPERTNIQNLNQLREDELGSDISALTLRISELESQVVEMHTSLILEKE 2619
Query: 357 KWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQE 416
+ E + LE E+K + + GN E+KQR K +K P+ E LK EL+
Sbjct: 2620 QVEIAEKNVLEKEKKLLELQKLLE--GN---EKKQREKEKKRSPQDVEVLKTTTELFHSN 2674
Query: 417 HSKAFMVNGQKF-MEYVAEQWEMHRLEKERAKQERQLKNKKQTETEM 462
F + E VA + E+ +++ K + +L K+ T +
Sbjct: 2675 EESGFFNELEALRAESVATKAELASYKEKAEKLQEELLVKETNMTSL 2721
Score = 37.4 bits (85), Expect = 0.037
Identities = 63/320 (19%), Positives = 134/320 (41%), Gaps = 26/320 (8%)
Query: 20 NHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTL 79
N + + E + +D + + + I +L D+ + S E + I+ QKE+ L
Sbjct: 672 NEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEIL 731
Query: 80 CSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELK-----------LLQEQD 128
E E+ + T+ Q ++L+ + EL+ KQ KE++ +L+ +L+++
Sbjct: 732 RQE-------EKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEK 784
Query: 129 QELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEEL 188
+ L ++L + + L+ + + +E + EE +K+Q I EE+
Sbjct: 785 KTLEDMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEI-LIEENEDLKQQCIQLNEEI 843
Query: 189 DHTPDT-SF-ERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIREL 246
+ +T SF E++ ++ E A L K+ LE K++ E + + E
Sbjct: 844 EKQRNTFSFAEKNFEVNYQEL----QEEYACLLKVKDDLEDSKNKQELEYKSKLKALNEE 899
Query: 247 WDRLQIPEEEREAVATIMSGSKAKVRKALQL-EVDRLEELKMQNMKKVIEAIRVELVQYW 305
+I + +++ K V + L++ EV + ++ +V + ++EL Q
Sbjct: 900 LHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRL 959
Query: 306 DQCFYSQEQRQAFAPFCAED 325
+Q+ F E+
Sbjct: 960 SDLSEQLKQKHGEISFLNEE 979
Score = 30.8 bits (68), Expect = 3.5
Identities = 56/276 (20%), Positives = 120/276 (43%), Gaps = 40/276 (14%)
Query: 35 QRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGET 94
+ L+ EVV+K EL++ + E + +E+L EL+ S+L + Q+ GE
Sbjct: 926 ETLEMGEVVEKDTTELMEKL---EVTKREKL---------ELSQRLSDLSEQLKQKHGEI 973
Query: 95 TILQLE-KDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEEL 153
+ L E K L+ + E + + +E + + + ++ + C+ S+ + + +
Sbjct: 974 SFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQV-------SSLLDGVVTM 1026
Query: 154 NQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLE 213
+ + K+ E + ++ ++ SFE V E+ L L+
Sbjct: 1027 TSRGAEGSVSKVNKSFGEESKIMVEDKV-------------SFENMTVGEESKQEQLILD 1073
Query: 214 NIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD-RLQIPEEEREAVATIMSGSKAKVR 272
++ ++ K Q S+N+ + + L E D RLQ+ E +R ++ + S +VR
Sbjct: 1074 HLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQM-EAQRICLSLVYSTHVDQVR 1132
Query: 273 KALQLEVDRL-----EELKMQNMKKVIEAIRVELVQ 303
+ ++ E D+ EEL +K+ E ++ ++
Sbjct: 1133 EYMENEKDKALCSLKEELIFAQEEKIKELQKIHQLE 1168
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 57.0 bits (136), Expect = 5e-08
Identities = 99/486 (20%), Positives = 204/486 (41%), Gaps = 75/486 (15%)
Query: 2 RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESL 61
R+ E L E+ +K ++W +++RL+ E ++E + M +E+ L
Sbjct: 276 RQEEELREQE----KKIRKQEEKMWR-----QEERLREQE---GKMREQEEKMWRQEKRL 323
Query: 62 KERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQEL 121
+E+ +KEL EL + E E + + E+ + Q E MR+Q+++ ++
Sbjct: 324 REQ--------EKELREQEKELREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQE 375
Query: 122 KLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQI 181
+ L EQ++++ E + EE + + LRE K R E + Q+
Sbjct: 376 ERLWEQEKQMRE---------QEQKMRDQEE--RMWEQDERLRE-KEERMREQEKMWEQV 423
Query: 182 ILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRT 241
EE E++ D++ E I +K +R+ E + E E ++
Sbjct: 424 EKMREE-----KKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQE---EKMQK 475
Query: 242 QIRELWDRLQIPEEEREAVATIMSGSKAKV--RKALQLEVDRL--EELKMQNMKKV---- 293
Q +W+ +EE+E + K K+ ++ +Q + +++ +E K+++ +++
Sbjct: 476 QEENMWE-----QEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQE 530
Query: 294 -----IEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVH 348
E +R + Q W+Q ++Q Q + E+ E Q + + +
Sbjct: 531 KKMWRQEKMREQEDQMWEQEEKMRDQEQKM--WDQEERMEKKTQEQEKKTWDQEEKMREE 588
Query: 349 KELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLL--KEEKQRAKLQKMLPKLEEEL 406
+ + E +K E + E E K + + +EEK + + +KM + E+
Sbjct: 589 ERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMW 648
Query: 407 KARIELWEQ-----------EHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNK 455
+ ++WEQ EH K M +K E + WE ++EK+ +QE++ ++
Sbjct: 649 EQEEKMWEQQRLPEQKEKLWEHEK--MQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ 706
Query: 456 KQTETE 461
++ E
Sbjct: 707 EKMREE 712
Score = 56.2 bits (134), Expect = 8e-08
Identities = 94/466 (20%), Positives = 202/466 (43%), Gaps = 83/466 (17%)
Query: 9 EESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKS 68
EE I ++ + E+W +++++ R E ++E D M +EE ++++ K
Sbjct: 510 EEKIWEQEEKIRDQEEMWG-----QEKKMWRQE----KMREQEDQMWEQEEKMRDQEQKM 560
Query: 69 ISVCQKELNTLCSELHVEPFQEEG----ETTILQLEKDLRTQVELMRKQKKERKQELKLL 124
++ + E + + +E E + + EK +R + E+MR+Q+++ +++ + +
Sbjct: 561 WDQ-EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 619
Query: 125 QEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILC 184
QEQ++++ E EE Q ++ +E K +EE + ++++
Sbjct: 620 QEQEEKMWE----------------QEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663
Query: 185 MEEL-DHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQI 243
E+L +H + E++ + E E +K+ Q +M+K E Q
Sbjct: 664 KEKLWEH--EKMQEQEKMQEQE-------------EKIWEQEKMEKKTQE--------QE 700
Query: 244 RELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQ 303
++ WD+ ++ EEE M + K+R+ + E+ R +E KMQ ++ ++ E+
Sbjct: 701 KKTWDQEKMREEES------MREREKKMRE--EEEMMREQEEKMQEQEEKMQEQEEEM-- 750
Query: 304 YWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWR 363
W+Q EQ + + K H+++ E + WE+ +
Sbjct: 751 -WEQEEKMWEQEEK--------------MWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEK 795
Query: 364 LFLEFERKASDPNRFTNRGGNLL-KEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFM 422
+ + E+ + + + +EEK + +KM + E+ ++W QE
Sbjct: 796 MRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEK 855
Query: 423 VNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAP 468
+ GQ+ E + EQ E R ++E+ +++ + K + Q E GS P
Sbjct: 856 MQGQE--EKMREQEEKMRGQEEKMREQEE-KMRGQEEKIYCVGSPP 898
Score = 53.5 bits (127), Expect = 5e-07
Identities = 89/429 (20%), Positives = 180/429 (41%), Gaps = 56/429 (13%)
Query: 41 EVVKKHIKELLDMM-IAEEESLKERL-IKSISVCQKELNTLCSELHVEPFQEEGETTILQ 98
E +KK EL + + +AE E + +L +K + + L ++ QEE
Sbjct: 221 EELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEM------ 274
Query: 99 LEKDLRTQVELMRKQKKERKQELKL------LQEQDQELCEILCMPHYDIDSASVPSLEE 152
R + EL ++KK RKQE K+ L+EQ+ ++ E + E+
Sbjct: 275 ----WRQEEELREQEKKIRKQEEKMWRQEERLREQEGKMRE----QEEKMWRQEKRLREQ 326
Query: 153 LNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFER-DVVCEDEDAFCLS 211
+ R+ LRE K R +E E++ + +E+ + + E E+
Sbjct: 327 EKELREQEKELREQKELREQE------------EQMQEQEEKMWEQEEKMREQEEKMWRQ 374
Query: 212 LENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKV 271
E + +K +R+ E + E ++RE +R++ E+ E V + K +
Sbjct: 375 EERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQVEKMREEKKMQE 434
Query: 272 RKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLL 331
Q + R +E KMQ +++ E R + ++ ++ QE++ + E++
Sbjct: 435 ----QEKKTRDQEEKMQEEERIRE--REKKMREEEETMREQEEKM-------QKQEENMW 481
Query: 332 QLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQ 391
+ + E + + E ++L+E +K +E E E K D + + ++EK
Sbjct: 482 EQEEKE-WQQQRLPEQKEKLWE-QEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKM 539
Query: 392 RAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEM-HRLEKERAKQER 450
R + +M + E+ ++W+QE +K E + W+ ++ +E +ER
Sbjct: 540 REQEDQMWEQEEKMRDQEQKMWDQEERME-----KKTQEQEKKTWDQEEKMREEERMRER 594
Query: 451 QLKNKKQTE 459
+ K +++ E
Sbjct: 595 EKKMREEEE 603
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 57.0 bits (136), Expect = 5e-08
Identities = 101/435 (23%), Positives = 188/435 (43%), Gaps = 26/435 (5%)
Query: 33 EDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
E++ ++ E V + +E L EEE ++R ++ ++L EL E +EE
Sbjct: 242 EEKEWRKRETVLRKEEEKLQ----EEEPQRQRELQEEEEQLRKLER--QELRRERQEEEQ 295
Query: 93 ETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEE 152
+ L+ E+ LR + E R++++E ++E + +EQ +E E + + E
Sbjct: 296 QQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQE-ERREQQLRRE 354
Query: 153 LNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSL 212
+ R+ RE + RRE+ + ++Q+ E + R+ E
Sbjct: 355 QEEERREQQLRREQEEERREQQLRREQQL---RREQQLRREQQLRREQQLRREQQLRRE- 410
Query: 213 ENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSK--AK 270
+ + Q+L R+ ++++ Q E E Q R RL+ +EER ++ +
Sbjct: 411 QQLRREQQLRREQQLRREQEEERHEQKHEQERR-EQRLKREQEERRDWLKREEETERHEQ 469
Query: 271 VRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESL 330
R+ QL+ D+ EE + + +K E R + + Q QE+R+ E+
Sbjct: 470 ERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQ 529
Query: 331 LQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNR-FTNRGGNLLKEE 389
+L + +R + +E E + K EE R LE ER+ R R LLK E
Sbjct: 530 QRLRSEQQLRRE-----QEERREQLLKREEEKR--LEQERREQRLKREQEERRDQLLKRE 582
Query: 390 KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQE 449
++R + Q++ + EE L+ R++ E E + Q+ E+ +L K ++E
Sbjct: 583 EER-RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEE 641
Query: 450 R---QLKNKKQTETE 461
R QL+ ++Q E
Sbjct: 642 RRQQQLRREQQERRE 656
Score = 52.4 bits (124), Expect = 1e-06
Identities = 99/466 (21%), Positives = 193/466 (41%), Gaps = 48/466 (10%)
Query: 27 ELIGIPEDQRLQ---RTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSEL 83
+L+ E++RL+ R + +K+ +E D ++ EE +++ +K ++ L
Sbjct: 548 QLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQ--EERLEQRLKRE 605
Query: 84 HVEPFQEEGETTILQLEKDLRTQVELMRKQ-KKERKQELKLLQEQDQELCEILCMPHYDI 142
VE +LE++ R + L R++ ++ER+Q+L +EQ++ + L +
Sbjct: 606 EVE-----------RLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQER 654
Query: 143 DSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVC 202
+ EE + Q + RE + RRE+ ++ + Q P ++ +
Sbjct: 655 REQRLKREEEEERLEQRLK--REHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712
Query: 203 EDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVAT 262
+ + S Q+ ++ E ++ + E+ L+ Q E R Q EE+R
Sbjct: 713 DARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE---LQWQEEERAHRQQQEEEQRRDFTW 769
Query: 263 IMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC 322
+ R +L L+ Q ++ +R E Q +Q F +E+ +
Sbjct: 770 QWQAEEKSERGRQRLSAR--PPLREQRERQ----LRAEERQQREQRFLPEEEEKEQRRRQ 823
Query: 323 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEET-----------WRLFLEFERK 371
+ + L L + E ++ + + +E +G+Q+ +E WR LE ERK
Sbjct: 824 RREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERK 883
Query: 372 ASDPNRFTNRGGNLLKEE--KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFM 429
R T L+E+ K++ LQ+ +L+ E + + EQE Q+
Sbjct: 884 R---RRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE 940
Query: 430 EYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRR 475
E + + R +ER +Q R+ K +Q E ++L P KRR
Sbjct: 941 EQLLREEREKRRRQERERQYRKDKKLQQKEEQLL----GEEPEKRR 982
Score = 51.6 bits (122), Expect = 2e-06
Identities = 93/486 (19%), Positives = 207/486 (42%), Gaps = 58/486 (11%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
+RR + L E + ++ L +++ + +Q+L+R + +++ +E E+E
Sbjct: 383 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQER 442
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKD-------LRTQVELMRKQ 113
++RL + ++ + L E E ++E L+ +++ L+ + E R+Q
Sbjct: 443 REQRLKRE---QEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQ 499
Query: 114 KKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREE 173
++ R+Q+L+ QE+ +E + EE + +Q LR + RRE+
Sbjct: 500 QERREQQLRREQEERRE--------------QRLKRQEEEERLQQR---LRSEQQLRREQ 542
Query: 174 FVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNE 233
+R+ +L EE E+ + E E+ + + ++ RQ +++ Q E
Sbjct: 543 --EERREQLLKREEEKRLEQERREQRLKREQEE----RRDQLLKREEERRQQRLKREQEE 596
Query: 234 AVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKV 293
+ + L+ RE +RL+ EE RE + + R+ L+ + EE + Q +++
Sbjct: 597 RLEQRLK---REEVERLE-QEERRE--QRLKREEPEEERRQQLLKSEEQEERRQQQLRR- 649
Query: 294 IEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFE 353
E + +Q +E+ + ++ E + AE + + + +
Sbjct: 650 ------EQQERREQRLKREEEEERLEQRLKREHEEERREQELAE----EEQEQARERIKS 699
Query: 354 GVQKWEETWRLFLEFERKASD----PNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKAR 409
+ KW+ W+L E + + S P + + +EEK+R + ++ + +EE +A
Sbjct: 700 RIPKWQ--WQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESEL--QWQEEERAH 755
Query: 410 IELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPR 469
+ E+E + F Q + + + R ++ERQL+ +++ + E +
Sbjct: 756 RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEE 815
Query: 470 TPSKRR 475
+RR
Sbjct: 816 EKEQRR 821
Score = 47.8 bits (112), Expect = 3e-05
Identities = 81/410 (19%), Positives = 175/410 (42%), Gaps = 40/410 (9%)
Query: 57 EEESLKER-LIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKK 115
+EE L+ R L++ ++E E FQEE E + E LR + E +++++
Sbjct: 206 DEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Query: 116 ERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFV 175
+R++EL+ +EQ ++L ++ ++ + R+ R+ + RRE+
Sbjct: 266 QRQRELQEEEEQLRKL------ERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQ-Q 318
Query: 176 SIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAV 235
+R+ E+ + + R+ E E Q+L R+ E ++ + +
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 236 CEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIE 295
E + ++L Q+ E+ ++R+ QL R ++L+ + + +
Sbjct: 379 REQQLRREQQLRREQQLRREQ-------------QLRREQQLR--REQQLRREQQLRREQ 423
Query: 296 AIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGV 355
+R E + + + QE+R+ E+ + L + + E ++ E K+ +
Sbjct: 424 QLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETE----RHEQERRKQQLKRD 479
Query: 356 QKWE--ETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELW 413
Q+ E E W E ER+ R + +QR K Q+ +L++ L++ +L
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 414 EQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEML 463
++ + E + ++ E RLE+ER +E++LK +++ + L
Sbjct: 540 REQEER---------REQLLKREEEKRLEQER--REQRLKREQEERRDQL 578
Score = 46.6 bits (109), Expect = 6e-05
Identities = 95/447 (21%), Positives = 189/447 (42%), Gaps = 58/447 (12%)
Query: 31 IPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQE 90
+ E+QRL+R E +K +K EE+ L+ CQ+ L + + +E
Sbjct: 1377 LEEEQRLRRQERERKFLK--------EEQQLR---------CQEREQQLRQDRDRKFREE 1419
Query: 91 EGETTILQLEKDLRTQVELMRKQKKERK---QELKLLQEQDQELCEILCMPHYDIDSASV 147
E + + + ++ R + + +R+Q++ERK +E +L QE+ ++ E + +
Sbjct: 1420 EQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFRE---------EEQLL 1470
Query: 148 PSLEELNQFRQHVTT--LRETKASRREEFVSIKRQIILCMEELDHTPDTSF-ERDVVCED 204
EE RQ L E + RR+E R+ L +E P+ F E +
Sbjct: 1471 QEREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQE----PERKFLEEEQQLHR 1526
Query: 205 EDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIM 264
+ L+ L++ R + ++ ++ E Q+R+ + Q+ +ER+ +
Sbjct: 1527 QQRQRKFLQEEQQLRRQERGQQRRQDRDRKFRE--EEQLRQEREEQQLSRQERDRKFRL- 1583
Query: 265 SGSKAKVRKALQLE--VDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC 322
+ KVR+ Q ++ ++L+ Q ++ + R + +Q +E++Q
Sbjct: 1584 --EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 323 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE----RKASDPNRF 378
+ E QL E + + + +K+ E +L E E R+ +F
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRH--------DRDRKFREEEQLLQEGEEQQLRRQERDRKF 1693
Query: 379 TNRGGNLLKEEKQRAKLQ--KMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQW 436
L ++E++R LQ + L + E E K R E ++ ++ + Q+ + E+
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEE- 1752
Query: 437 EMHRLEKERAKQERQLKNKKQTETEML 463
E R E+E + RQ +++K E E L
Sbjct: 1753 EQLRPEREEQQLRRQERDRKFREEEQL 1779
Score = 43.5 bits (101), Expect = 5e-04
Identities = 87/450 (19%), Positives = 179/450 (39%), Gaps = 50/450 (11%)
Query: 33 EDQRLQRTEVVKKHIKELLDMMIAEEES------LKERLIKSISVCQKELNTLCSELHVE 86
E++RL++ + ++H +E + +AEEE +K R+ K + E + S+++
Sbjct: 664 EEERLEQ-RLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR 722
Query: 87 PFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELC-------------- 132
P ++EG+ + E+ R + ++ Q++ER + +EQ ++
Sbjct: 723 PRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQ 782
Query: 133 EILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEE----- 187
+ P EE Q Q E K RR + ++++ EE
Sbjct: 783 RLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQR 842
Query: 188 LDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC---EGLRTQIR 244
+ E D + ED++ + QK QLE ++ + L+ Q+R
Sbjct: 843 RERAQQLQEEEDGLQEDQER--RRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 245 ELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
+ LQ EEE + + K R+ Q R EE Q ++++ R + +
Sbjct: 901 KEQQLLQEEEEE------LQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQ 954
Query: 305 WDQCFYSQEQR--QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETW 362
+ Y ++++ Q E+ + Q + + + + ++L + E
Sbjct: 955 ERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLL----REEREK 1010
Query: 363 RLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFM 422
R E+ER+ + LL+EE+++ +LQ+ E + + EL ++E +
Sbjct: 1011 RRRQEWERQYRKKDELQQEEEQLLREEREKRRLQER----ERQYREEEELQQEEEQ---L 1063
Query: 423 VNGQKFMEYVAEQWEMHRLEKERAKQERQL 452
+ ++ E +R E+E ++E QL
Sbjct: 1064 LGEERETRRRQELERQYRKEEELQQEEEQL 1093
Score = 41.6 bits (96), Expect = 0.002
Identities = 102/494 (20%), Positives = 202/494 (40%), Gaps = 73/494 (14%)
Query: 27 ELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVE 86
+L+G E++ +R + +++ ++ ++ EE+ L+E K ++E C E E
Sbjct: 1062 QLLG--EERETRRRQELERQYRKEEELQQEEEQLLREEPEKRR---RQERERQCRE--EE 1114
Query: 87 PFQEEGETTILQLEKDLRTQVELMRKQKKE---RKQELKLLQEQDQELCEILCMPHYDID 143
Q+E E +L+ E++ R + EL R+ ++E +++E +LL+E+ ++ Y +
Sbjct: 1115 ELQQE-EEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREE 1173
Query: 144 SASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSF----ERD 199
E+L + Q + R EE + +++ +E D D + E++
Sbjct: 1174 EELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDE-DQRSDLKWQWEPEKE 1232
Query: 200 VVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVC------EGLRTQIRELWDRLQ-- 251
D +C EN Q QL ++SQ + E R Q R W +
Sbjct: 1233 NAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRH 1292
Query: 252 IPEEER----EAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQ 307
PEEE+ E K++ K L L +R E+ + Q + L + +Q
Sbjct: 1293 FPEEEQLEREEQKEAKRRDRKSQEEKQL-LREEREEKRRRQETDRKFREEEQLLQEREEQ 1351
Query: 308 CFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLE 367
QE+ + F + L + + +R + + + ++ E +L +
Sbjct: 1352 PLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQD 1411
Query: 368 FERKASDPNRFTNRG--GNLLKEEKQRAKLQKMLPK-LEEELKARIE------------- 411
+RK + + +R +EE+Q+ + Q+ K LEEE + R E
Sbjct: 1412 RDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 412 ------LWEQEHSKAFMVNGQ---------KFME-----------YVAEQWEMHRLEKER 445
L QE + F+ Q KF E ++ E+ ++HR +++R
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531
Query: 446 --AKQERQLKNKKQ 457
++E+QL+ +++
Sbjct: 1532 KFLQEEQQLRRQER 1545
Score = 40.8 bits (94), Expect = 0.003
Identities = 96/449 (21%), Positives = 178/449 (39%), Gaps = 55/449 (12%)
Query: 36 RLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETT 95
R QR ++ ++ + EE KE+ + +KEL L E E Q
Sbjct: 791 REQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEE---EQLQRRERAQ 847
Query: 96 ILQLEKD-LRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELN 154
LQ E+D L+ E R Q++ R Q+ + E++++ + P+L+E
Sbjct: 848 QLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLY--------AKPALQE-- 897
Query: 155 QFRQHVTTLRETKAS-RREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLE 213
Q R+ L+E + +REE +RQ +E + E + + ++E+
Sbjct: 898 QLRKEQQLLQEEEEELQREEREKRRRQ----EQERQYR-----EEEQLQQEEEQLLREER 948
Query: 214 NIATLQKLLRQLEMQKS--QNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKV 271
Q+ RQ K Q E G + R +R + EE E + + +
Sbjct: 949 EKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEE----LQQEEEQLL 1004
Query: 272 RKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLL 331
R+ + E R +E + Q KK EL Q +Q + +++ + E L
Sbjct: 1005 RE--EREKRRRQEWERQYRKKD------ELQQEEEQLLREEREKRRLQERERQYREEEEL 1056
Query: 332 QLHDAEIV----------RLKNYYEVHKELF---EGVQKWEETWRLFLEFERKASDPNRF 378
Q + +++ L+ Y +EL E + + E R E ER+ +
Sbjct: 1057 QQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEEL 1116
Query: 379 TNRGGNLLKEEKQRAKLQKMLPKLEEELKARIE----LWEQEHSKAFMVNGQKFMEYVAE 434
LL+EE+++ + Q++ + EE + + E L E+ + +++ E
Sbjct: 1117 QQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEEL 1176
Query: 435 QWEMHRLEKERAKQERQLKNKKQTETEML 463
Q E +L +E ++ RQ + ++ E E L
Sbjct: 1177 QQEEEQLLREEQEKRRQERERQYREEEEL 1205
Score = 32.7 bits (73), Expect = 0.91
Identities = 27/115 (23%), Positives = 56/115 (48%), Gaps = 17/115 (14%)
Query: 33 EDQRLQRTEVVKKHIKEL-------LDMMIAEEESLKERLIKSISVCQKELNTLCSELHV 85
E+Q+L+R E +K ++E L+ EEE L++ + Q+ + E +
Sbjct: 1696 EEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQL 1755
Query: 86 EPFQEEGETTILQLEKDLRTQVEL--------MRKQKKERK--QELKLLQEQDQE 130
P +EE + + ++ R + +L +R Q+ +RK +E +L QE++++
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQ 1810
Score = 30.0 bits (66), Expect = 5.9
Identities = 31/112 (27%), Positives = 53/112 (47%), Gaps = 14/112 (12%)
Query: 33 EDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
E+Q+L+R E +K +E EE+ L+ + +++L E + P Q +G
Sbjct: 1760 EEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDG 1819
Query: 93 ----ETTILQLEKD---LRTQ-------VELMRKQKKERKQELKLLQEQDQE 130
E LQLE+ LR + E Q+K R++E +L QE++Q+
Sbjct: 1820 KYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQK 1871
>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
Length = 2230
Score = 57.0 bits (136), Expect = 5e-08
Identities = 89/432 (20%), Positives = 183/432 (42%), Gaps = 52/432 (12%)
Query: 43 VKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELH-------------VEPFQ 89
VK+ E L ++E + +L + +SV + + + + EL V+
Sbjct: 681 VKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSII 740
Query: 90 EEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPS 149
+E E +I + EK L+ Q+ + KER + LK Q + L + ++ AS
Sbjct: 741 KEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEADIKRSEGELQQASA-- 798
Query: 150 LEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEE----LDHTPDTSFERDVVCEDE 205
+L+ F+ + + E + E+ ++++++ E + ++ VC +
Sbjct: 799 --KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKDVCTEL 856
Query: 206 DAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMS 265
DA + + Q L++QLE Q S+ E + L TQ+ E +L+ +E+E I+
Sbjct: 857 DAHKIQV------QDLMQQLEKQNSEMEQKVKSL-TQVYE--SKLEDGNKEQEQTKQILV 907
Query: 266 GSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELV-QYWDQCFYSQEQRQAFAPFCAE 324
K LQ+ + +E+++ K + + ++ + ++ F +QE++ A+
Sbjct: 908 ---EKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAK 964
Query: 325 DYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGN 384
+ E+L + + +LK E+ E QK ++ LE + S ++
Sbjct: 965 EMQETLKKKLLDQEAKLKK--ELENTALELSQKEKQFNAKMLEMAQANSAG--ISDAVSR 1020
Query: 385 LLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKE 444
L E Q+ +++ + EL I +WE+ K + E E+H ++ +
Sbjct: 1021 L--ETNQKEQIESLTEVHRRELNDVISIWEK-----------KLNQQAEELQEIHEIQLQ 1067
Query: 445 RAKQE-RQLKNK 455
+QE +LK K
Sbjct: 1068 EKEQEVAELKQK 1079
Score = 50.4 bits (119), Expect = 4e-06
Identities = 99/457 (21%), Positives = 183/457 (40%), Gaps = 91/457 (19%)
Query: 22 LREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCS 81
LR I EL + LQ + KKH++E D + E++ ISV Q +++ L
Sbjct: 186 LRRIAEL-----REELQMDQQAKKHLQEEFDASLEEKDQY-------ISVLQTQVSLLKQ 233
Query: 82 ELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYD 141
L P + + QLE Q E+ K++ +++
Sbjct: 234 RLRNGPMNVDVLKPLPQLEP----QAEVFTKEENPESDGEPVVE---------------- 273
Query: 142 IDSASVPSLEELNQ-FRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDV 200
D SV +LE L Q ++ L+ K E S K Q L E + + ER
Sbjct: 274 -DGTSVKTLETLQQRVKRQENLLKRCK----ETIQSHKEQCTLLTSEKEALQEQLDER-- 326
Query: 201 VCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAV 260
L++LE K + A L TQ+R+ + ++ E+++
Sbjct: 327 ---------------------LQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDK--- 362
Query: 261 ATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAP 320
+++ +K ++ + L+++ + + +L R + Q Q +EQ++
Sbjct: 363 GMVIAETKRQMHETLEMKEEEIAQL------------RSRIKQMTTQGEELREQKEKSER 410
Query: 321 FCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTN 380
E+ ++L E R K E+ +++ + ++K E R+ L+ E +R
Sbjct: 411 AAFEELEKALSTAQKTEEARRKLKAEMDEQI-KTIEKTSEEERISLQQEL-----SRVKQ 464
Query: 381 RGGNLLKE--EKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEM 438
+++K+ E+Q AKLQK+ E+EL + EQE +K ++F E + E
Sbjct: 465 EVVDVMKKSSEEQIAKLQKLH---EKELARK----EQELTKKLQTREREFQEQMKVALEK 517
Query: 439 HRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRR 475
+ E + QE++ + E L A T S+ +
Sbjct: 518 SQSEYLKISQEKEQQESLALEELELQKKAILTESENK 554
Score = 45.1 bits (105), Expect = 2e-04
Identities = 102/502 (20%), Positives = 209/502 (41%), Gaps = 74/502 (14%)
Query: 3 RSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTE-VVKKHIKEL------LDMMI 55
+++ + +E + + NH ++ + I + +QRTE +K I +L D +
Sbjct: 713 QTDKMKQELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHL 772
Query: 56 AEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG--------ETTILQLEK---DLR 104
E ++ E L I + EL ++L V + E + QL++ DL
Sbjct: 773 KEHQAHVENLEADIKRSEGELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLE 832
Query: 105 TQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLR 164
T+ L+ KQ E ++ Q +++C L + ++ ++ Q V +L
Sbjct: 833 TERILLTKQVAE-------VEAQKKDVCTELDAHKIQVQDLMQQLEKQNSEMEQKVKSLT 885
Query: 165 ETKASRREE----------FVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLEN 214
+ S+ E+ + K +IL M E + + +++ L+ E
Sbjct: 886 QVYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEY 945
Query: 215 IATLQKLLRQLEMQKSQNEAVCEGLRTQI--------RELWDR-LQIPEEEREAVATIMS 265
+ +++E K + + + E L+ ++ +EL + L++ ++E++ A ++
Sbjct: 946 ETKFKNQEKKMEKVKQKAKEMQETLKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLE 1005
Query: 266 GSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVEL---VQYWDQCFYSQEQRQAFAPFC 322
++A + V RLE + + ++ + E R EL + W++ Q +
Sbjct: 1006 MAQAN-SAGISDAVSRLETNQKEQIESLTEVHRRELNDVISIWEKKLNQQAEE------- 1057
Query: 323 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRL-FLEFERKASDPNRFTNR 381
++ E LQ + E+ LK K L G +K E + +L+ E D
Sbjct: 1058 LQEIHEIQLQEKEQEVAELKQ-----KILLFGCEKEEMNKEITWLKEEGVKQDTTL---- 1108
Query: 382 GGNLLKEE-KQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQW-EMH 439
N L+E+ KQ++ L + E +LKA +E E + +K+ N ++ EQ E+
Sbjct: 1109 --NELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKEN-----TFLQEQLVELK 1161
Query: 440 RLEKERAKQERQLKNKKQTETE 461
L +E ++ +L +K +T E
Sbjct: 1162 MLAEEDKRKVSELTSKLKTTDE 1183
Score = 43.9 bits (102), Expect = 4e-04
Identities = 98/487 (20%), Positives = 196/487 (40%), Gaps = 92/487 (18%)
Query: 15 LQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKEL---LDMMIAEEESLKERLIKSISV 71
L+ L L E + I Q + E + IK + ++ ++ E+E+L
Sbjct: 1274 LEAQLRQLTEEQNTLNISFQQATHQLEEKENQIKSMKADIESLVTEKEAL---------- 1323
Query: 72 CQKELNTLCSELHVEPFQEEGETTILQLEKDLR---TQVELMRKQKKERKQELKLLQEQ- 127
QKE + + E E+ I QL+K+L V LM+++ KE+K E+ L +Q
Sbjct: 1324 -QKEGG------NQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQL 1376
Query: 128 ---------------------------DQELCEILCMPH---YDIDSASVPSLEELNQFR 157
D+E CE+L + +D+ S + L Q
Sbjct: 1377 TDLNVQLQNSISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVD 1436
Query: 158 QHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
E K + F + + +L+ ++E+D E I
Sbjct: 1437 DWSNKFSEWKKKAQSRFTQHQNTVKELQIQLELKSKEAYEKD-------------EQINL 1483
Query: 218 LQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQL 277
L++ L Q + + E ++++ + L+ E + A IM +K +++
Sbjct: 1484 LKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLE--TELKSQTARIMELEDHITQKTIEI 1541
Query: 278 EVDRLEELKMQNMKKVIEAIR-VELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDA 336
E E LK N +K IE V+ +Q++ + ++ R ++ E +L L +
Sbjct: 1542 E-SLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNR-------VKEAEEKILTLEN- 1592
Query: 337 EIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQ 396
++ +K E K+ E V ++ E E KA + +R + L E K++A +
Sbjct: 1593 QVYSMKAELETKKKELEHVNLSVKS----KEEELKALE-DRLESESAAKLAELKRKA--E 1645
Query: 397 KMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKK 456
+ + ++++L +++E E+++ K + + + E+ E+E E +LK+ +
Sbjct: 1646 QKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQER------EREVHILEEKLKSVE 1699
Query: 457 QTETEML 463
+++E L
Sbjct: 1700 SSQSETL 1706
Score = 42.4 bits (98), Expect = 0.001
Identities = 84/427 (19%), Positives = 184/427 (43%), Gaps = 57/427 (13%)
Query: 23 REIWELIGIPEDQRLQRTEVVKKHI---KELLDMMIAEEESLKERLIKSISVCQKELNT- 78
R++ E + + E++ Q +K+ +EL + E + E L K++S QK
Sbjct: 371 RQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEAR 430
Query: 79 --LCSEL--HVEPFQEEGETTILQLEKDL----RTQVELMRKQKKERKQELKLLQE---- 126
L +E+ ++ ++ E + L+++L + V++M+K +E+ +L+ L E
Sbjct: 431 RKLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELA 490
Query: 127 -QDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCM 185
++QEL + L + +LE+ ++ +E + S E + ++++ IL
Sbjct: 491 RKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAIL-- 548
Query: 186 EELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRE 245
T + RD+ E E LE ++L+K +Q+++N Q ++
Sbjct: 549 -----TESENKLRDLQQEAETYRTRILELESSLEK-----SLQENKN---------QSKD 589
Query: 246 LWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYW 305
L L+ + + T+M ++L+ + D L K+Q +K + + E+ +
Sbjct: 590 LAVHLEAEKNKHNKEITVMVEKHKTELESLKHQQDALWTEKLQVLK---QQYQTEMEKLR 646
Query: 306 DQCFYSQE----QRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEE- 360
++C +E ++ E+ E L+ D + L++ E+ + K EE
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706
Query: 361 -------TWRLFLEFERKASD-PNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIEL 412
T ++ E E K + N + +++KE + +Q+ L++++ ++EL
Sbjct: 707 LSVLKDQTDKMKQELEAKMDEQKNHHQQQVDSIIKEHE--VSIQRTEKALKDQIN-QLEL 763
Query: 413 WEQEHSK 419
+E K
Sbjct: 764 LLKERDK 770
Score = 41.6 bits (96), Expect = 0.002
Identities = 84/394 (21%), Positives = 163/394 (41%), Gaps = 67/394 (17%)
Query: 101 KDLRTQVELMRKQKKERKQELKLLQEQ-DQELCEILCMPHYDIDSASVPSLEELN----- 154
K+L+ Q+EL K+ E+ +++ LL+E+ DQ+ C+ D S +E N
Sbjct: 1461 KELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDKSKMEKKESNLETEL 1520
Query: 155 --------QFRQHVTTLRETKASRREEFVSIKRQIIL----CMEELDHTPDTSFERDVVC 202
+ H+T S E + +Q + +++L H + E+D
Sbjct: 1521 KSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKELVQKLQHFQELGEEKDNRV 1580
Query: 203 EDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRT---QIRELWDRLQIPEEEREA 259
++ + L+LEN + + +LE +K + E V +++ +++ L DRL+ + A
Sbjct: 1581 KEAEEKILTLEN--QVYSMKAELETKKKELEHVNLSVKSKEEELKALEDRLESESAAKLA 1638
Query: 260 VATIMSGSK-AKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAF 318
+ K A ++K L +++ EE + + + + +L + + +E+ ++
Sbjct: 1639 ELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNTKLQEREREVHILEEKLKS- 1697
Query: 319 APFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEG-VQKWEETWRLFLEFERKASDPNR 377
+E+L+ A+ V Y E + +G VQK +E K S R
Sbjct: 1698 ---VESSQSETLIVPRSAKNVAA--YTEQEEADSQGCVQK---------TYEEKISVLQR 1743
Query: 378 FTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIE--------LWEQEHSKAFMVNGQKFM 429
NL ++EK LQ++ + EE + + E L + EH++A Q +
Sbjct: 1744 ------NLTEKEK---LLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 430 EYVAEQWE----------MHRLEKERAKQERQLK 453
++ E+ E +EKE K Q K
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAK 1828
Score = 41.2 bits (95), Expect = 0.003
Identities = 99/514 (19%), Positives = 202/514 (39%), Gaps = 87/514 (16%)
Query: 9 EESIVCLQKALNHLREIWELIGIPEDQRLQ-RTEVVKKHIKELLDMMIAEEESLKER-LI 66
EE I LQ+ L ++ + +G +++ + E+ ++ + L+ + AE + +++ +I
Sbjct: 1735 EEKISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMI 1794
Query: 67 KSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQE 126
+ +E N S + + ++EG +Q +++L + ++K +E++ ++L++
Sbjct: 1795 GHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQ 1854
Query: 127 QDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCME 186
+ +EL DS V RQ +E EE S K + + ++
Sbjct: 1855 KIKEL-----------DSCLV---------RQ-----KEVHRVEMEELTS-KYEKLQALQ 1888
Query: 187 ELD-HTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRE 245
++D T + E + + + ++ ++ LE + + E + L +I
Sbjct: 1889 QMDGRNKPTELLEENTEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVR 1948
Query: 246 LWDRLQIPEEEREAVATIMSGSKAKVRKA-LQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
L L++ +E + I+ + R+ ++ E + LE +K+++ +L Q
Sbjct: 1949 LQKDLRMLRKEHQQELEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQ- 2007
Query: 305 WDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRL 364
E L++ E + EV EL E Q EET +L
Sbjct: 2008 ----------------------KEQELEMTIKETINKAQ--EVEAELLESHQ--EETNQL 2041
Query: 365 FLEFERKASDPNRFTNRGGNLL--KEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFM 422
+ K D R R +L +EE+ AK++ + +LEE K + EQE +
Sbjct: 2042 LKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLEQEENPG-- 2099
Query: 423 VNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTP 482
+ + L+ + A++ + + K E E R N
Sbjct: 2100 ----------NDNVTIMELQTQLAQKTTLISDSKLKEQEF------------REQIHNLE 2137
Query: 483 GKARKLNTTTMSNATANSSIRPIFGGTVYHSPVS 516
+ +K N A + P GG +YH+ VS
Sbjct: 2138 DRLKKYE----KNVYATTVGTPYKGGNLYHTDVS 2167
Score = 40.0 bits (92), Expect = 0.006
Identities = 61/263 (23%), Positives = 106/263 (40%), Gaps = 51/263 (19%)
Query: 2 RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHI-KELLDMMIAEEES 60
R + L +E IV LQK L LR+ + Q E++KK +E + + E+E
Sbjct: 1937 REKQKLGKE-IVRLQKDLRMLRK----------EHQQELEILKKEYDQEREEKIKQEQED 1985
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQ-LEKDLRTQVELMRKQKKERKQ 119
L+ + ++ +E NT ++ ++E E TI + + K + EL+ ++E Q
Sbjct: 1986 LELKHNSTLKQLMREFNTQLAQK-----EQELEMTIKETINKAQEVEAELLESHQEETNQ 2040
Query: 120 ELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKR 179
LK + E+D +L ++ E +R EE + R
Sbjct: 2041 LLKKIAEKDDDL-------------------------KRTAKRYEEILDAREEEMTAKVR 2075
Query: 180 QIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGL 239
+ +EEL E++ +++ I LQ L Q S ++ +
Sbjct: 2076 DLQTQLEELQKKYQQKLEQEENPGNDNV------TIMELQTQLAQKTTLISDSKLKEQEF 2129
Query: 240 RTQIRELWDRLQIPEEEREAVAT 262
R QI L DRL+ + E+ AT
Sbjct: 2130 REQIHNLEDRLK--KYEKNVYAT 2150
Score = 39.3 bits (90), Expect = 0.010
Identities = 109/534 (20%), Positives = 207/534 (38%), Gaps = 89/534 (16%)
Query: 15 LQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIK---SISV 71
L + L H +E+ E +D R++ E ++ + M AE E+ K+ L S+
Sbjct: 1562 LVQKLQHFQELGE----EKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617
Query: 72 CQKELNTLCSELHVEP------FQEEGETTILQLEKDLRTQVELMRKQKK---------- 115
++EL L L E + + E I ++K L +Q+E +Q K
Sbjct: 1618 KEEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSEL 1677
Query: 116 -----ERKQELKLLQEQ----DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRET 166
ER++E+ +L+E+ + E L +P + A+ EE + + V E
Sbjct: 1678 NTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADS-QGCVQKTYEE 1736
Query: 167 KASRREEFVSIKRQIILCM-EELDHTPDTSFE-----RDVVCEDEDAFCLSLENIATLQK 220
K S + ++ K +++ + +E + T + FE ++ + + E A E+ + +
Sbjct: 1737 KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGH 1796
Query: 221 LLRQLEMQKSQNEAVC------EGLRTQIR------ELWDRLQIPEEEREAVATIMSGSK 268
L +LE + + + EG + I+ ++D +Q +E+E I+
Sbjct: 1797 LQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI 1856
Query: 269 AKVRKAL--QLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDY 326
++ L Q EV R+E ++ + + ++A++ Q + E+
Sbjct: 1857 KELDSCLVRQKEVHRVEMEELTSKYEKLQALQ-------------QMDGRNKPTELLEEN 1903
Query: 327 TESLLQLHDAEIVRLKNYYEVHKEL-FEGVQKWEETWRLFLEFERKASD----------- 374
TE + H + L N H +L F+ E +L E R D
Sbjct: 1904 TEEKSKSHLVQPKLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQE 1963
Query: 375 ----PNRFTNRGGNLLKEEKQRAKLQ--KMLPKLEEELKARIELWEQEHSKAFMVNGQKF 428
+ +K+E++ +L+ L +L E ++ EQE K
Sbjct: 1964 LEILKKEYDQEREEKIKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKA 2023
Query: 429 MEYVAEQWEMHRLE-----KERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGL 477
E AE E H+ E K+ A+++ LK + E+L +K R L
Sbjct: 2024 QEVEAELLESHQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDL 2077
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 56.6 bits (135), Expect = 6e-08
Identities = 87/450 (19%), Positives = 197/450 (43%), Gaps = 37/450 (8%)
Query: 19 LNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
++ L + W+ G E Q L KK ++ + E ++L L ++ ++ +EL
Sbjct: 225 ISRLHDSWKFAGELE-QALSAVATQKKKADRYIEELTKERDALSLELYRN-TITDEELKE 282
Query: 79 LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCM- 137
++L QE+ LQL + +++++L K+ K + + KLL Q Q E +
Sbjct: 283 KNAKL-----QEK-----LQLVESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLG 332
Query: 138 PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSF- 196
SA + + E N+ + +E K R+EE + + I EE +
Sbjct: 333 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 392
Query: 197 -ERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
+ + + E+ E + ++++ + E + + E + +IREL +++ E+
Sbjct: 393 EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEK 452
Query: 256 EREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVI----EAIRVELVQYWDQCFYS 311
RE + + K + E + +E KM ++ I E IR + + W Q
Sbjct: 453 IRE-----QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKI 507
Query: 312 QEQRQAFAPFCAEDYTESLLQ----LHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLE 367
EQ + ++ E Q EI R K ++H E E ++K EE +++ +
Sbjct: 508 HEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKE--KIH-EQEEKIRKQEE--KMWRQ 562
Query: 368 FERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQK 427
E+ + + + ++E++ + ++ + + EE+++ + E+ +++ K G++
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKM----GEQ 618
Query: 428 FMEYVAEQWEMHRLEKERAKQERQLKNKKQ 457
+ ++ +M E++ +QE +++ +++
Sbjct: 619 EEKMCEQEEKMQEQEEKMRRQEEKIREQEK 648
Score = 55.1 bits (131), Expect = 2e-07
Identities = 91/423 (21%), Positives = 194/423 (45%), Gaps = 50/423 (11%)
Query: 56 AEEESLKERLIKSISV---CQKELNTLCSELHVEPFQEEG----ETTILQLEKDLRTQVE 108
AE + L + L +S+S Q E N L + L+ + QEE E I + E+ ++ Q E
Sbjct: 326 AEADHLGKEL-QSVSAKLQAQVEENELWNRLNQQ--QEEKMWRQEEKIQEWEEKIQEQEE 382
Query: 109 LMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKA 168
+R+Q+++ +++ + ++ Q++ + E EE + ++ + +E K
Sbjct: 383 KIREQEEKIREQEEKMRRQEEMMWE----------------KEEKMRRQEEMMWEKEEKM 426
Query: 169 SRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQ 228
R+EE + K + I +EE H + E++ ++E+ + K+ RQ E
Sbjct: 427 RRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKI 486
Query: 229 KSQNEAVCEG---LRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEEL 285
+ Q E + E + Q ++ ++ +I EEE+ M + K+R+ Q E+ R +E
Sbjct: 487 REQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIRE--QEEIWRQKE- 543
Query: 286 KMQNMKKVIEAIRVELVQYW--DQCFYSQEQR---QAFAPFCAEDYTESLLQLHDAEIVR 340
+ + E IR + + W ++ + QE++ Q + E+ + + +
Sbjct: 544 ---KIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEK 600
Query: 341 LKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLP 400
++ E+ +E E + + EE E E K + R ++E++++ + Q+
Sbjct: 601 IREQEEMTQEQEEKMGEQEEK---MCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKI 657
Query: 401 KLEEELKARIE--LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQT 458
+ +EE+ E +WEQE M ++ M+ ++ +M R E++ +QE +L+ +++
Sbjct: 658 REQEEMMQEQEEKMWEQEEK---MCEQEEKMQ--EQEEKMRRQEEKMWEQEVRLRQQEEK 712
Query: 459 ETE 461
E
Sbjct: 713 MQE 715
Score = 47.4 bits (111), Expect = 4e-05
Identities = 58/259 (22%), Positives = 110/259 (42%), Gaps = 44/259 (16%)
Query: 215 IATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKA 274
I L K L ++ +N E L+ + +L ++LQ+ E E+ + + K K+ +A
Sbjct: 256 IEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNVKELKRKLERA 315
Query: 275 --------LQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDY 326
LQ E D L + ++Q++ ++A +VE + W++ QE++
Sbjct: 316 KLLLPQQQLQAEADHLGK-ELQSVSAKLQA-QVEENELWNRLNQQQEEK----------- 362
Query: 327 TESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLL 386
+ E +E E +Q+ EE R E E K + R ++
Sbjct: 363 --------------MWRQEEKIQEWEEKIQEQEEKIR---EQEEKIREQEEKMRRQEEMM 405
Query: 387 --KEEKQRAKLQKMLPKLEEELKARIELWEQEHS----KAFMVNGQKFMEYVAEQWEMHR 440
KEEK R + + M K E+ + +WE+E + M +K E ++ E +
Sbjct: 406 WEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEK 465
Query: 441 LEKERAKQERQLKNKKQTE 459
+ ++ +QE++ K +Q E
Sbjct: 466 IREQEKRQEQEAKMWRQEE 484
Score = 35.8 bits (81), Expect = 0.11
Identities = 28/115 (24%), Positives = 63/115 (54%), Gaps = 10/115 (8%)
Query: 22 LREIWELIGIPEDQRLQRTEVVKKH---IKELLDMMIAEEESLKERLIKSISVCQKELNT 78
+RE E + E++ ++ E +++ I+E +M +EE + E+ K +C++E
Sbjct: 573 IREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEK---MCEQEEKM 629
Query: 79 LCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCE 133
E + +E+ I + EK +R Q E +R+Q++ +++ + + EQ++++CE
Sbjct: 630 QEQEEKMRRQEEK----IREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCE 680
Score = 33.9 bits (76), Expect = 0.41
Identities = 60/325 (18%), Positives = 132/325 (40%), Gaps = 29/325 (8%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
MRR E + E +++ + E E + E+ ++ E +++ +++ + E+
Sbjct: 398 MRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQE 457
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
K + + I +K E E E I + E+ + Q E + +Q+K R++E
Sbjct: 458 EKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE 517
Query: 121 LKLLQE----------QDQELCEILCMPHYDID------------SASVPSLEELNQFRQ 158
+ QE + +E+ H + + EE + ++
Sbjct: 518 KRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQE 577
Query: 159 HVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSF--ERDVVCEDEDAFCLSLENIA 216
+E K +EE + + + I EE+ + + + +CE E+ E +
Sbjct: 578 EKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEKMR 637
Query: 217 TLQKLLRQLEMQ-KSQNEAVCEG---LRTQIRELWDRLQIPEEEREAVATIMSGSKAKVR 272
++ +R+ E + + Q E + E ++ Q ++W++ + E+ E + + +
Sbjct: 638 RQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 697
Query: 273 KALQLEVD-RLEELKMQNMKKVIEA 296
K + EV R +E KMQ ++ +EA
Sbjct: 698 KMWEQEVRLRQQEEKMQEHQEHLEA 722
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 55.8 bits (133), Expect = 1e-07
Identities = 91/457 (19%), Positives = 194/457 (42%), Gaps = 47/457 (10%)
Query: 24 EIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSEL 83
E+W +++ L+ E K I++ + M +EE L+E+ K +K
Sbjct: 235 EMWR-----QEEELREQE---KKIRKQEEKMWRQEERLREQEGKMREQEEK--------- 277
Query: 84 HVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI---LCMPHY 140
E + + EK+LR Q + +R+QKK R+QE + +QEQ++++ E +
Sbjct: 278 -----MRRQEKRLREQEKELREQEKELREQKKLREQE-EQMQEQEEKMWEQEEKMREQEE 331
Query: 141 DIDSASVPSLEELNQFRQHVTTLR--ETKASRREEFVSIKRQIILCMEELDHTPDTSFER 198
+ E+ Q R+ +R E + ++E + K + + E++ + E
Sbjct: 332 KMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEE 391
Query: 199 DVVCEDEDAFCLSLENIATLQKLLRQLE---MQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
+ + E E E + ++ +++ E ++ + E + L Q +LW++ ++ E+
Sbjct: 392 ERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQ 451
Query: 256 EREAVATIMSGSKAKVRKALQL-----EVDRLEELKMQN--MKKVIEAIRVELVQYWDQC 308
E + + + K+R ++ ++ R E+++ Q M + E +R + + WDQ
Sbjct: 452 EEK-----IWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQE 506
Query: 309 FYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEF 368
EQ + + + + ++ K E K+ ++ +K E R+ E
Sbjct: 507 ERMWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERM-RER 565
Query: 369 ERKASDPNRFTNRGGNLLKE--EKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQ 426
E+K + ++E EK R + +KM + E+ + ++WEQE
Sbjct: 566 EKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625
Query: 427 KFMEYVAEQWEM-HRLEKERAKQERQLKNKKQTETEM 462
K E WE +++++ K Q + ++ E +M
Sbjct: 626 KMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKM 662
Score = 55.5 bits (132), Expect = 1e-07
Identities = 107/497 (21%), Positives = 205/497 (41%), Gaps = 93/497 (18%)
Query: 2 RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESL 61
R+ E L E+ +K ++W +++RL+ E ++E + M +E+ L
Sbjct: 238 RQEEELREQE----KKIRKQEEKMWR-----QEERLREQE---GKMREQEEKMRRQEKRL 285
Query: 62 KERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQ-------- 113
+E+ K + +KEL E +E E + + E+ +R Q E M +Q
Sbjct: 286 REQE-KELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQE 344
Query: 114 KKERKQELKL------LQEQDQELCEIL-CMPHYDIDSASVPSLEELNQFRQHVTTLRET 166
K+ R+QE K+ + EQD+ L E M + ++E + R+ +RE
Sbjct: 345 KQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREE 404
Query: 167 KASRREEFVSIKRQIILCMEE---------LDHTPDTSFERDVVCEDEDAFCLSLENIAT 217
+ + RE+ +++Q E+ L + +E++ + E E+ E I
Sbjct: 405 EETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRD 464
Query: 218 LQ-------KLLRQLEMQKSQNEA--VCEGLRTQIRELWDRLQIPEEEREAVATIMSGSK 268
+ K+ RQ +M++ +++ E +R Q +++WD+ + E+ E + +
Sbjct: 465 QEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMR 524
Query: 269 AKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTE 328
+ +K Q E EE K Q +K + WDQ +E+ +
Sbjct: 525 EQ-KKMWQQEEKMREEKKTQEQEK----------KTWDQEEKMREEER------------ 561
Query: 329 SLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKE 388
+ + E +++ E+ +E E +Q+ EE R E E K + +E
Sbjct: 562 ----MRERE-KKMREEEEMMREQEEKMQEQEEKMR---EQEEKMWEQEEKMQE-----QE 608
Query: 389 EKQRAKLQKMLPKLEEELKARIE--LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERA 446
EK + +KM + EE+ E +WEQE +K E + WE +E+
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQE---------EKMQEQEEKMWEQEEKMREQE 659
Query: 447 KQERQLKNKKQTETEML 463
++ R+ + K Q + E +
Sbjct: 660 EKMREQEEKMQGQEEKM 676
Score = 55.1 bits (131), Expect = 2e-07
Identities = 86/436 (19%), Positives = 184/436 (42%), Gaps = 41/436 (9%)
Query: 41 EVVKKHIKELLDMMIAEEESLKERL-IKSISVCQKELNTLCSELHVEPFQEEGETTILQL 99
E+ KK+ + + +AE E + +L +K + + L ++ QEE
Sbjct: 184 ELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEM------- 236
Query: 100 EKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQH 159
R + EL ++KK RKQE K+ +++++ + E+ + R+
Sbjct: 237 ---WRQEEELREQEKKIRKQEEKMWRQEER------------LREQEGKMREQEEKMRRQ 281
Query: 160 VTTLRETKASRREEFVSIKRQIIL--CMEELDHTPDTSFER-DVVCEDEDAFCLSLENIA 216
LRE + RE+ ++ Q L E++ + +E+ + + E E+ E +
Sbjct: 282 EKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW 341
Query: 217 TLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ 276
+K +R+ E + E ++RE +R++ E+ E + + + R+
Sbjct: 342 EQEKQMREQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKM 401
Query: 277 LEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQ---- 332
E + + + M+K E + + + W Q +++ + + ++ E + +
Sbjct: 402 REEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEK 461
Query: 333 LHDAEIV--RLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEK 390
+ D E + + K + K + Q WE+ ++ + E+K D L+E++
Sbjct: 462 IRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKM-RDQEQKMWDQEERMWEQDERLREKE 520
Query: 391 QRAKLQKML----PKLEEELKARIE---LWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEK 443
+R + QK + K+ EE K + + W+QE ++ + + E+ EM R E+
Sbjct: 521 ERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR-EQ 579
Query: 444 ERAKQERQLKNKKQTE 459
E QE++ K ++Q E
Sbjct: 580 EEKMQEQEEKMREQEE 595
Score = 45.8 bits (107), Expect = 1e-04
Identities = 89/420 (21%), Positives = 170/420 (40%), Gaps = 62/420 (14%)
Query: 16 QKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKE 75
QK + +WE +D+RL+ E + ++E M EE+ +E I+ +E
Sbjct: 352 QKMRDQEERMWE-----QDERLREKE---ERMREQEKMWEQEEKMQEEERIREREKKMRE 403
Query: 76 LNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEIL 135
E E Q++ E Q EK+ + Q ++KE+ E + +QEQ++++ E
Sbjct: 404 EEETMREQE-EKMQKQEENMWEQEEKEWQQQ---RLPEQKEKLWEQEKMQEQEEKIWE-- 457
Query: 136 CMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTS 195
I +E +RQ +E + +EE + + Q + EE
Sbjct: 458 --QEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE------RM 509
Query: 196 FERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRE--LWDRLQ-I 252
+E+D E + ++ +R+ + Q E + E +TQ +E WD+ + +
Sbjct: 510 WEQD-------------ERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKM 556
Query: 253 PEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQ 312
EEER M + K+R+ + E+ R +E KMQ + E +R + + W+Q Q
Sbjct: 557 REEER------MREREKKMRE--EEEMMREQEEKMQEQE---EKMREQEEKMWEQEEKMQ 605
Query: 313 EQRQAF----APFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEF 368
EQ + ++ + + + + + + E ++++E +K E E
Sbjct: 606 EQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQ 665
Query: 369 ERKASDPNRFTNRGGNLLK---------EEKQRAKLQKMLPKLEEELKARIELWEQEHSK 419
E K ++ EEK R + +KM + E+ ++W QE +
Sbjct: 666 EEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMR 725
Score = 44.7 bits (104), Expect = 2e-04
Identities = 53/268 (19%), Positives = 124/268 (46%), Gaps = 27/268 (10%)
Query: 9 EESIVCLQKALNHLREIW--ELIGIPEDQRLQRTEVVKKHIKELLDM---MIAEEESLKE 63
EE I ++ +++W E + EDQ ++ E ++ +++ D M ++E L+E
Sbjct: 459 EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLRE 518
Query: 64 RLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKL 123
+ + QK++ ++ E +E E E+ +R + E MR+++K+ ++E ++
Sbjct: 519 KEERMRE--QKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREE-ERMREREKKMREEEEM 575
Query: 124 LQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIIL 183
++EQ++++ E EE + ++ +E K +EE + + + +
Sbjct: 576 MREQEEKMQE----------------QEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMW 619
Query: 184 CMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQI 243
EE D + + +++ E E+ E + ++ +R+ E + + E +G ++
Sbjct: 620 EQEEEDKMQE---QEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKM 676
Query: 244 RELWDRLQIPEEEREAVATIMSGSKAKV 271
RE +++Q EE+ M G + K+
Sbjct: 677 REQEEKMQGQEEKMREQEEKMRGQEEKM 704
Score = 29.6 bits (65), Expect = 7.7
Identities = 27/131 (20%), Positives = 65/131 (49%), Gaps = 16/131 (12%)
Query: 1 MRRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEES 60
MR E + E +Q+ +RE E + E++ ++ E + + +++ + EE+
Sbjct: 569 MREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQ--EEEDK 626
Query: 61 LKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQE 120
++E Q+E+ E +E E + + E+ +R Q E MR+Q+++ + +
Sbjct: 627 MQE---------QEEMMW-----EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQ 672
Query: 121 LKLLQEQDQEL 131
+ ++EQ++++
Sbjct: 673 EEKMREQEEKM 683
>gi|153791497 ciliary rootlet coiled-coil [Homo sapiens]
Length = 2017
Score = 55.5 bits (132), Expect = 1e-07
Identities = 108/478 (22%), Positives = 203/478 (42%), Gaps = 84/478 (17%)
Query: 3 RSEVLAEESIVCLQKALNHL---REIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEE 59
+ VLA+E +V +++AL+ R++ + + L + E + ++ + + AEE
Sbjct: 674 KRSVLAKE-LVEVREALSRATLQRDMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEA 732
Query: 60 SLKERLIK------SISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQ 113
SL++ L K S++ + +LN L ++L E E + LQ + Q + ++
Sbjct: 733 SLQDSLSKLSALNESLAQDKLDLNRLVAQL-------EEEKSALQGRQRQAEQEATVARE 785
Query: 114 KKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQ-FRQHVTTLRETKASRRE 172
++ER +EL+L QE ++ E S+ E+ + Q + TLR ++ +E
Sbjct: 786 EQERLEELRLEQEVARQGLE-----------GSLRVAEQAQEALEQQLPTLRHERSQLQE 834
Query: 173 EFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQN 232
+ + RQ+ +EL+ R+ + E +LE A ++ L + +
Sbjct: 835 QLAQLSRQLSGREQELEQA-----RREAQRQVE-----ALERAAREKEALAKEHAGLAVQ 884
Query: 233 EAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKK 292
E + E RL++ E+EA + GS +V++ L R E+L+ +
Sbjct: 885 LVAAEREGRTLSEEATRLRL---EKEA----LEGSLFEVQRQLAQLEARREQLEAEGQAL 937
Query: 293 VI--EAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKE 350
++ E + EL Q +QE+ A E + L+Q L+ H+E
Sbjct: 938 LLAKETLTGELAGLRQQIIATQEK----ASLDKELMAQKLVQAEREAQASLREQRAAHEE 993
Query: 351 LFEGVQKWEE-TWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKAR 409
+ +Q+ +E WR + E +RA+LQ L + +EEL AR
Sbjct: 994 DLQRLQREKEAAWR-----------------------ELEAERAQLQSQLQREQEELLAR 1030
Query: 410 IELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTE-TEMLYGS 466
+E ++E S+ Q E+ E L + +Q LK ++T +E L G+
Sbjct: 1031 LEAEKEELSEEIAALQQ-------ERDEGLLLAESEKQQALSLKESEKTALSEKLMGT 1081
Score = 50.1 bits (118), Expect = 6e-06
Identities = 115/505 (22%), Positives = 199/505 (39%), Gaps = 56/505 (11%)
Query: 2 RRSEVLAEESIVCLQKA-----LNHLREIWELIGIPEDQRLQRTEVVKKHIK-------E 49
RR ++ AE + L K L LR+ ++I E L + + +K ++
Sbjct: 926 RREQLEAEGQALLLAKETLTGELAGLRQ--QIIATQEKASLDKELMAQKLVQAEREAQAS 983
Query: 50 LLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVEL 109
L + A EE L +RL + +EL ++L + Q E E + +LE + E
Sbjct: 984 LREQRAAHEEDL-QRLQREKEAAWRELEAERAQLQSQ-LQREQEELLARLEAEKEELSEE 1041
Query: 110 MRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKAS 169
+ ++ER + L L + + Q+ + +S E+L R + T+
Sbjct: 1042 IAALQQERDEGLLLAESEKQQALSLK-------ESEKTALSEKLMGTRHSLATISLEMER 1094
Query: 170 RREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQK 229
++ + S + Q + L TS RD+ + E+A + + LQ+ R L Q+
Sbjct: 1095 QKRDAQSRQEQDRSTVNAL-----TSELRDLRAQREEAAAAHAQEVRRLQEQARDLGKQR 1149
Query: 230 SQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQ-LEVDRLEELKMQ 288
E LRTQ+R L E+ R+ + + ++ K+R++ + EV R E +++
Sbjct: 1150 DSCLREAEELRTQLRLL-------EDARDGLRRELLEAQRKLRESQEGREVQRQEAGELR 1202
Query: 289 NM----KKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNY 344
K EA+R + ++ +R + ED + L L +A K
Sbjct: 1203 RSLGEGAKEREALRRSNEELRSAVKKAESERISL-KLANEDKEQKLALLEEARTAVGKEA 1261
Query: 345 YEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPK--L 402
E+ L E + E R E R+ + R G L E + R L + K
Sbjct: 1262 GELRTGLQEVERSRLEARRELQELRRQMKMLDSENTRLGRELAELQGRLALGERAEKESR 1321
Query: 403 EEELKARIELWEQEHSKAFM-----VNGQKFMEYVAEQWEMHR-----LEKERAKQERQL 452
E L R L + E S M V +K E E R LE+ R +++QL
Sbjct: 1322 RETLGLRQRLLKGEASLEVMRQELQVAQRKLQEQEGEFRTRERRLLGSLEEARGTEKQQL 1381
Query: 453 KNKKQTETEMLYGSAPRTPSKRRGL 477
+ + E ++ A R + GL
Sbjct: 1382 DHARGLELKL---EAARAEAAELGL 1403
Score = 40.0 bits (92), Expect = 0.006
Identities = 75/352 (21%), Positives = 133/352 (37%), Gaps = 32/352 (9%)
Query: 81 SELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEIL--CMP 138
S LH Q + + +DL + +RKQ + + E + L+EQ Q L + M
Sbjct: 526 SALHKRQLQVQDMRGRYEASQDL---LGTLRKQLSDSESERRALEEQLQRLRDKTDGAMQ 582
Query: 139 HYDIDSASVPSLEELNQF----RQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
++ V L N+ + ++ + + EE + ++ EEL D
Sbjct: 583 AHEDAQREVQRLRSANELLSREKSNLAHSLQVAQQQAEELRQEREKLQAAQEELRRQRDR 642
Query: 195 SFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRL---- 250
E E EDA L++ RQLE + + + + L ++RE R
Sbjct: 643 LEE-----EQEDAVQDGARVRRELERSHRQLEQLEGKRSVLAKEL-VEVREALSRATLQR 696
Query: 251 -QIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCF 309
+ E+ E + +V L + R EE +Q+ + A+ L Q D+
Sbjct: 697 DMLQAEKAEVAEALTKAEAGRVELELSMTKLRAEEASLQDSLSKLSALNESLAQ--DKLD 754
Query: 310 YSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE 369
++ Q + +S LQ + + +E E ++ +E R LE
Sbjct: 755 LNRLVAQL-------EEEKSALQGRQRQAEQEATVAREEQERLEELRLEQEVARQGLEGS 807
Query: 370 -RKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA 420
R A + L+ E R++LQ+ L +L +L R + EQ +A
Sbjct: 808 LRVAEQAQEALEQQLPTLRHE--RSQLQEQLAQLSRQLSGREQELEQARREA 857
>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
Length = 1960
Score = 55.1 bits (131), Expect = 2e-07
Identities = 84/367 (22%), Positives = 157/367 (42%), Gaps = 32/367 (8%)
Query: 109 LMRKQKKERKQEL---KLLQEQDQELCEILCMPHYDIDSASVPSL------EELNQFRQH 159
L RK +R+Q+L K+LQ ++ + + + P L EE+ +
Sbjct: 794 LARKAFAKRQQQLTAMKVLQRNCAAYLKLRNWQWWRLFTKVKPLLQVSRQEEEMMAKEEE 853
Query: 160 VTTLRETKASRREEFVSIKR-QIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATL 218
+ +RE + + ++ Q L E+L E ++ E E+ L
Sbjct: 854 LVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAETELCAEAEELRARLTAKKQEL 913
Query: 219 QKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLE 278
+++ LE + + E C+ L+ + +++ +Q EE+ E + R+ LQLE
Sbjct: 914 EEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLE--------EEESARQKLQLE 965
Query: 279 VDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAE- 337
E +KK+ E E + DQ ++++ AE +T +L + +
Sbjct: 966 KVTTEA----KLKKLEE----EQIILEDQNCKLAKEKKLLEDRIAE-FTTNLTEEEEKSK 1016
Query: 338 -IVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQ 396
+ +LKN +E E + EE R LE R+ + + T+ + + + Q A+L+
Sbjct: 1017 SLAKLKNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDS-TDLSDQIAELQAQIAELK 1075
Query: 397 KMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHR-LEKERAKQERQLKNK 455
L K EEEL+A + E+E ++ M +K E ++ E+ LE ERA + + K K
Sbjct: 1076 MQLAKKEEELQAALARVEEEAAQKNMAL-KKIRELESQISELQEDLESERASRNKAEKQK 1134
Query: 456 KQTETEM 462
+ E+
Sbjct: 1135 RDLGEEL 1141
Score = 51.6 bits (122), Expect = 2e-06
Identities = 106/432 (24%), Positives = 176/432 (40%), Gaps = 77/432 (17%)
Query: 52 DMMIAEEESLKERLIKSISVCQK--ELNTLCSELHVEPFQEEGETTILQLEKDLRTQVEL 109
+MM EEE +K R K ++ + E+ TL S+L E Q + + LQ E +L + E
Sbjct: 846 EMMAKEEELVKVRE-KQLAAENRLTEMETLQSQLMAEKLQLQEQ---LQAETELCAEAEE 901
Query: 110 MRKQKKERKQELKLL-------QEQDQELCEILCMPHYDID---SASVPSLEELNQFRQ- 158
+R + +KQEL+ + E+++E C+ L + LEE RQ
Sbjct: 902 LRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQK 961
Query: 159 ----HVTTLRETKASRREEFVSIKRQIILCME-ELDHTPDTSFERDVVCEDEDAFCLS-L 212
VTT + K E+ + + L E +L F ++ E+E + L+ L
Sbjct: 962 LQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKL 1021
Query: 213 EN-----IATLQKLLRQLEMQKSQNEAV---CEG-----------LRTQIRELWDRLQIP 253
+N I L++ LR+ E Q+ + E EG L+ QI EL +L
Sbjct: 1022 KNKHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLAKK 1081
Query: 254 EEEREAVATIMSGSKAKVRKALQ---------------LEVDRLEELKMQNMKK----VI 294
EEE +A + A+ AL+ LE +R K + K+ +
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141
Query: 295 EAIRVELVQYWDQCFYSQEQR--QAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELF 352
EA++ EL D QE R + + E + H+A+I ++ + E
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVE-- 1199
Query: 353 EGVQKWEETWRLFLEFER-KASDPNR-----------FTNRGGNLLKEEKQRAKLQKMLP 400
E ++ E+T R+ E+ K + N +G + K +K A+LQ++
Sbjct: 1200 ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQLQELQV 1259
Query: 401 KLEEELKARIEL 412
K E + R EL
Sbjct: 1260 KFNEGERVRTEL 1271
Score = 49.7 bits (117), Expect = 7e-06
Identities = 98/443 (22%), Positives = 181/443 (40%), Gaps = 39/443 (8%)
Query: 36 RLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEP-FQEEGET 94
+L++ E K +E L+ EEE K L K I+ ++ + ++ E E
Sbjct: 1330 KLKQVEDEKNSFREQLE----EEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEE 1385
Query: 95 TILQLEKDL----RTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVPSL 150
+L+KDL + E + K K + +L QE D L ++ D S +L
Sbjct: 1386 VKRKLQKDLEGLSQRHEEKVAAYDKLEKTKTRLQQELDDLLVDL------DHQRQSACNL 1439
Query: 151 EE----LNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCED-E 205
E+ +Q T+ A R+ + R+ L + + E+ E
Sbjct: 1440 EKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLN 1499
Query: 206 DAFCLSLENIATLQ----KLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVA 261
F +E++ + + K + +LE K E E ++TQ+ EL D LQ E+ + +
Sbjct: 1500 KQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVEEMKTQLEELEDELQATEDAKLRLE 1559
Query: 262 TIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPF 321
+ KA+ + LQ ++ EE K Q +++V E + EL E++Q
Sbjct: 1560 VNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVRE-MEAEL---------EDERKQRSMAV 1609
Query: 322 CAEDYTESLLQLHDAEIVRL-KNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTN 380
A E L+ +A I KN E K+L + + ++ R + +AS
Sbjct: 1610 AARKKLEMDLKDLEAHIDSANKNRDEAIKQLRKLQAQMKDCMREL--DDTRASREEILAQ 1667
Query: 381 RGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHR 440
N K + A++ ++ +L +A+ + ++ A + +A + E R
Sbjct: 1668 AKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANSSGKGALALE-EKRR 1726
Query: 441 LEKERAKQERQLKNKKQTETEML 463
LE A+ E +L+ ++Q TE++
Sbjct: 1727 LEARIAQLEEELE-EEQGNTELI 1748
Score = 40.8 bits (94), Expect = 0.003
Identities = 66/312 (21%), Positives = 129/312 (41%), Gaps = 52/312 (16%)
Query: 16 QKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAE----------EESLKE-- 63
+K +R++ E+ ED+R QR+ V K +D+ E +E++K+
Sbjct: 1582 EKKKQLVRQVREMEAELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIKQLR 1641
Query: 64 RLIKSISVCQKELN-TLCSELHVEPFQEEGETTILQLEKDL-RTQVELMRKQKKERKQEL 121
+L + C +EL+ T S + +E E + +E ++ + Q EL ++ +R+ +
Sbjct: 1642 KLQAQMKDCMRELDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQ- 1700
Query: 122 KLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQI 181
QE+D+ EI + +LEE + + L E + I ++
Sbjct: 1701 ---QERDELADEIA-----NSSGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRL 1752
Query: 182 ILCMEELDH-TPDTSFERDVVCEDEDA----------FCLSLENI--------------- 215
++D D + ER ++E+A + L+ +
Sbjct: 1753 KKANLQIDQINTDLNLERSHAQKNENARQQLERQNKELKVKLQEMEGTVKSKYKASITAL 1812
Query: 216 -ATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD-RLQIPEEEREAVATIMSGSKAKVR- 272
A + +L QL+ + + +A C+ +R ++L D LQ+ +E R A KA R
Sbjct: 1813 EAKIAQLEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRL 1872
Query: 273 KALQLEVDRLEE 284
K L+ +++ EE
Sbjct: 1873 KQLKRQLEEAEE 1884
Score = 30.8 bits (68), Expect = 3.5
Identities = 95/454 (20%), Positives = 175/454 (38%), Gaps = 73/454 (16%)
Query: 22 LREIWELIGIPEDQRLQ---RTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNT 78
L+++ E I EDQ + ++++ I E + EEE K L K + + +
Sbjct: 973 LKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKS-LAKLKNKHEAMITD 1031
Query: 79 LCSELHVEPFQ-EEGETTILQLE---KDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
L L E Q +E E T +LE DL Q+ ++ Q E K +L ++++EL
Sbjct: 1032 LEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQIAELKMQLA---KKEEELQAA 1088
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
L + ++ +L+++ + ++ L+E S R ++Q
Sbjct: 1089 LARVEEEAAQKNM-ALKKIRELESQISELQEDLESERASRNKAEKQ-------------- 1133
Query: 195 SFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPE 254
+RD+ E+ +A LE+ TL Q E+ +S+ E L+ + E +
Sbjct: 1134 --KRDLG-EELEALKTELED--TLDSTAAQQEL-RSKREQEVNILKKTLEE-----EAKT 1182
Query: 255 EEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQ 314
E + S+A A QLE + + ++ K+ +E R EL +
Sbjct: 1183 HEAQIQEMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGD 1242
Query: 315 RQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKE----------LFEGVQKWEETWRL 364
+ E ++ ++ E VR + +V K L + K + +
Sbjct: 1243 SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQVELDNVTGLLSQSDSKSSKLTKD 1302
Query: 365 FLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKA-RIELWEQEHSKAFMV 423
F E + D L +E +Q+ L L ++E+E + R +L E+E +K
Sbjct: 1303 FSALESQLQDTQEL------LQEENRQKLSLSTKLKQVEDEKNSFREQLEEEEEAK---- 1352
Query: 424 NGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQ 457
H LEK+ A Q+ + K+
Sbjct: 1353 ---------------HNLEKQIATLHAQVADMKK 1371
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 53.1 bits (126), Expect = 7e-07
Identities = 98/487 (20%), Positives = 200/487 (41%), Gaps = 55/487 (11%)
Query: 2 RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKK--HIKELLDMMIAEEE 59
+R E + E++ ++ + +++ W +G Q+ ++++ H + M E+
Sbjct: 137 KRQEKMNEKNYTFRKRVV--IKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEK 194
Query: 60 SLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQ 119
KER S+ + + NT+ E E E E L+L + +++++L K K + +
Sbjct: 195 LTKERDAPSLELYR---NTITDEELKEKNAELQEK--LRLVESEKSEIQLNVKDLKRKLE 249
Query: 120 ELKLLQEQDQELCEILCM-PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIK 178
+LL Q Q E + SA + + E N+ + +E K R+EE + +
Sbjct: 250 RAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ-E 308
Query: 179 RQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQ-KLLRQLEMQKSQNEAVCE 237
++ +C +EL + + + E+ E I + K+ RQ E + Q E +
Sbjct: 309 QEEKMCEQELKIRE----QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKI-- 362
Query: 238 GLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQN--MKKVIE 295
R Q ++W + + E+ E + + K + E R E++ Q M++ E
Sbjct: 363 --REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDE 420
Query: 296 AIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGV 355
IR + + W Q E + +L + + + EV +++ E
Sbjct: 421 KIREQEEEMWRQ-------------------EEKIRELEEMMQDQEEKLREVEEKMQEEE 461
Query: 356 QKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQ 415
+K +E E K + T R LLK+E++ + ++ + + EE ++WEQ
Sbjct: 462 EKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEE------KMWEQ 515
Query: 416 EHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLK--------NKKQTETEMLYGSA 467
E + E + E+ ++E QE++++ K + E+L G+
Sbjct: 516 EEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAG 575
Query: 468 PRTPSKR 474
+ S+R
Sbjct: 576 RESGSQR 582
Score = 37.0 bits (84), Expect = 0.048
Identities = 57/292 (19%), Positives = 135/292 (46%), Gaps = 39/292 (13%)
Query: 22 LREIWELIGIPEDQRLQRTEVVKKH---IKELLDMMIAEEESLKERLIKSISVCQKELNT 78
+RE E I E++ ++ E +++ I+E + M +EE ++E+ K ++
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKK 414
Query: 79 LCSELHVEPFQEEG----ETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
+ + QEE E I +LE+ ++ Q E +R+ +++ ++E + +QEQ++++
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI--- 471
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
Q ++ +E K R+E+ + + +I E++ +
Sbjct: 472 --------------------QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511
Query: 195 SFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPE 254
+E++ ++++ E + ++ +R+ E++ Q E + +++EL +RL
Sbjct: 512 MWEQEEKMQEQE------EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLG 565
Query: 255 EEREAV--ATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
++ E + A SGS+ L+V+ L+ + Q++++ + R L QY
Sbjct: 566 QKAELLGGAGRESGSQRLPTLTPILQVE-LKSQEAQSLQQQQDHYRGHLQQY 616
>gi|87298937 centrosomal protein 110kDa [Homo sapiens]
Length = 2325
Score = 53.1 bits (126), Expect = 7e-07
Identities = 97/464 (20%), Positives = 189/464 (40%), Gaps = 94/464 (20%)
Query: 9 EESIVCLQKALNHLREIWELI---------GIPEDQRLQRTEVVKK--HIKELLDMMIAE 57
++ + L + L H +E L+ + E RL TEV +K HI+E+
Sbjct: 1593 QQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIREV------- 1645
Query: 58 EESLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKER 117
+ L++ +S + ELN SE + + E I + E++L+ + M K K E
Sbjct: 1646 -----KSLLEELSFQKGELNVQISERKTQLTLIKQE--IEKEEENLQVVLRQMSKHKTEL 1698
Query: 118 KQELKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSI 177
K L +LQ ++ EL + Q Q V+ L +T+ + EE + +
Sbjct: 1699 KNILDMLQLENHELQGLKL------------------QHDQRVSELEKTQVAVLEEKLEL 1740
Query: 178 KRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCE 237
+ + ++ + +++ ++ D+ LQ + L +K + C+
Sbjct: 1741 ENLQQISQQQKG---EIEWQKQLLERDKREIERMTAESRALQSCVECLSKEKEDLQEKCD 1797
Query: 238 GLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAI 297
++ + L EE + + + + VRK LQ E+D+L K+ ++ I A+
Sbjct: 1798 IWEKKLAQTKRVLAAAEENSKMEQSNLEKLELNVRK-LQQELDQLNRDKL-SLHNDISAM 1855
Query: 298 RVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQK 357
+ +L QE+R+A SL + E+ ++++ + K+ K
Sbjct: 1856 QQQL----------QEKREA---------VNSLQE----ELANVQDHLNLAKQDLLHTTK 1892
Query: 358 WEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEH 417
++ L E R D + + NR + KEE+ + Q+ L L+ E++
Sbjct: 1893 HQDV--LLSEQTRLQKDISEWANRFEDCQKEEETK---QQQLQVLQNEIE---------- 1937
Query: 418 SKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTETE 461
+ ++ V ++ RL+KER +E +L+ K T E
Sbjct: 1938 --------ENKLKLVQQEMMFQRLQKERESEESKLETSKVTLKE 1973
Score = 38.5 bits (88), Expect = 0.017
Identities = 77/363 (21%), Positives = 145/363 (39%), Gaps = 68/363 (18%)
Query: 32 PEDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEE 91
P D +L+ E + L + E E +++++++ +E L + ++ E
Sbjct: 434 PLDTQLEDKEKKISAAQTRLSELHDEIEKAEQQILRAT----EEFKQLEEAIQLKKISEA 489
Query: 92 GETTI-------LQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDS 144
G+ + LQL LR + + Q +++KQE+ Q++ ++L
Sbjct: 490 GKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDL------------Q 537
Query: 145 ASVPSLEELNQFRQHVTTLRETKA--------------SRREEFVSIKRQIILCMEELDH 190
++ SL+ + H+ + K SR +E +S +I EE+
Sbjct: 538 IAIDSLDSKDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILS---RIAKETEEIKD 594
Query: 191 TPDTSFERDVVCEDEDAFCLSLENIAT-LQKLLRQLEMQKSQNEAVCEGLRTQIRELWDR 249
+ E + + A LE + + LQ+ L ++ Q +Q + C LR + L R
Sbjct: 595 LEEQLTEGQIAANE--ALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQR 652
Query: 250 LQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCF 309
L E+ER+ QLE+ ++ +NM+K + + L + +
Sbjct: 653 LTEVEQERD-----------------QLEIVAMD---AENMRKELAELESALQEQHEVNA 692
Query: 310 YSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFE 369
Q+ + + + AE E+ L L DAE +LK E L Q + + LE E
Sbjct: 693 SLQQTQGDLSAYEAE--LEARLNLRDAEANQLKEELEKVTRL---TQLEQSALQAELEKE 747
Query: 370 RKA 372
R+A
Sbjct: 748 RQA 750
Score = 35.0 bits (79), Expect = 0.18
Identities = 117/595 (19%), Positives = 224/595 (37%), Gaps = 124/595 (20%)
Query: 18 ALNHLREIWELIGIPEDQR-----LQRTE----VVKKHIKELLDMMIAEEESLKERLIKS 68
A N +E+ EL ++Q LQ+T+ + ++ L++ AE LKE L K
Sbjct: 670 AENMRKELAELESALQEQHEVNASLQQTQGDLSAYEAELEARLNLRDAEANQLKEELEKV 729
Query: 69 ISVCQKELNTLCSELHVE-----------PFQEEGETTILQLE---KDLRTQVELMRKQK 114
+ Q E + L +EL E F EE E +L K L+ L+++Q
Sbjct: 730 TRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSELHAKLKHLQDDNNLLKQQL 789
Query: 115 K------------------------ERKQELKL-----------------LQEQDQELCE 133
K E +++LKL L + ++ E
Sbjct: 790 KDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGEMNIHSPSDVLGKSLADLQKQFSE 849
Query: 134 ILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPD 193
IL ++ D A V + ++ + +E A+ +EEF RQ E D
Sbjct: 850 ILARSKWERDEAQVRE----RKLQEEMALQQEKLATGQEEF----RQACERALEARMNFD 901
Query: 194 TSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIP 253
+ + E+ EN+ +++++ ++Q + + E + Q+REL + ++
Sbjct: 902 KRQHEARIQQMENEIHYLQENLKSMEEIQGLTDLQLQEADEEKERILAQLRELEKKKKLE 961
Query: 254 EEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQE 313
+ + + + K++KA+ D+L ++ K ++++ +++ + +
Sbjct: 962 DAKSQEQVFGLDKELKKLKKAVATS-DKLATAELTIAKDQLKSLHGTVMKINQERAEELQ 1020
Query: 314 QRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKAS 373
+ + F+ A+ + L +AEI L+N E F LE E+
Sbjct: 1021 EAERFSRKAAQAARD--LTRAEAEIELLQNLLRQKGEQFR------------LEMEKTGV 1066
Query: 374 DPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVA 433
T +L+ EK +++ ++ L+ ++L ++ F + +E +A
Sbjct: 1067 G----TGANSQVLEIEKLNETMERQRTEI-ARLQNVLDLTGSDNKGGF----ENVLEEIA 1117
Query: 434 EQWEMHRLEKERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLAPNTPGKARKLNTTTM 493
E L +E + Q Y S+ P KRRG P ++
Sbjct: 1118 E------LRREVSYQND-------------YISSMADPFKRRGYWYFMPPPPSSKVSSHS 1158
Query: 494 SNATANSSIRPIFGGTVYHSPVSRLPP------SGSKPVAASTCSGKKTPRTGRH 542
S AT +S + + + +PV + P GS+P AS R+G H
Sbjct: 1159 SQATKDSGVGLKYSAS---TPVRKPRPGQQDGKEGSQPPPASGYWVYSPIRSGLH 1210
Score = 34.7 bits (78), Expect = 0.24
Identities = 48/229 (20%), Positives = 98/229 (42%), Gaps = 19/229 (8%)
Query: 99 LEKDLRTQVELMRKQKKERKQE--LKLLQEQDQELCEILCMPHYDIDSASVPSLEELNQF 156
LE ++ ++M+ K ++++E ++ + Q ++ E L H++ID L+E
Sbjct: 1321 LENEVSRLEDIMQHLKSKKREERWMRASKRQSEKEMEEL---HHNIDDL----LQEKKSL 1373
Query: 157 RQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIA 216
V L T R+++ I + M EL+ D+V E E L+ +
Sbjct: 1374 ECEVEELHRTVQKRQQQKDFIDGNVESLMTELEIEKSLKHHEDIVDEIECIEKTLLKRRS 1433
Query: 217 TLQKLLRQLEMQKSQNEAVCEGLRTQIRELWD--------RLQIPEEEREAVATIMSGSK 268
L++ R L +S+ E + + + D E ER A T ++ K
Sbjct: 1434 ELREADRLLAEAESELSCTKEKTKNAVEKFTDAKRSLLQTESDAEELERRAQETAVNLVK 1493
Query: 269 AKVR-KALQLEVDRLEELKMQNMKKVIEAIRVELVQYWD-QCFYSQEQR 315
A + ++LQ + LE+ K++ + + E ++ + D QC ++++
Sbjct: 1494 ADQQLRSLQADAKDLEQHKIKQEEILKEINKIVAAKDSDFQCLSKKKEK 1542
Score = 33.9 bits (76), Expect = 0.41
Identities = 89/472 (18%), Positives = 182/472 (38%), Gaps = 86/472 (18%)
Query: 31 IPEDQRLQ----RTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVE 86
+PE L+ R E + +H+K K+R + + +++ ELH
Sbjct: 1315 VPEHHNLENEVSRLEDIMQHLKS------------KKREERWMRASKRQSEKEMEELH-- 1360
Query: 87 PFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSAS 146
+LQ +K L +VE + + ++R+Q+ + + L M +I+
Sbjct: 1361 ----HNIDDLLQEKKSLECEVEELHRTVQKRQQQKDFIDGNVESL-----MTELEIEK-- 1409
Query: 147 VPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPD---------TSFE 197
SL+ + + +T RR E R + EL T + T +
Sbjct: 1410 --SLKHHEDIVDEIECIEKTLLKRRSELREADRLLAEAESELSCTKEKTKNAVEKFTDAK 1467
Query: 198 RDVVCEDEDAFCLSL-------------ENIATLQKLLRQLEMQKSQNEAVCEGLRTQIR 244
R ++ + DA L + + +LQ + LE K + E + + + +
Sbjct: 1468 RSLLQTESDAEELERRAQETAVNLVKADQQLRSLQADAKDLEQHKIKQEEILKEINKIVA 1527
Query: 245 ELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
Q +++E + + + + A + E L+ LK + +++A R EL +
Sbjct: 1528 AKDSDFQCLSKKKEKLTEELQKLQKDIEMAERNEDHHLQVLKESEV--LLQAKRAELEKL 1585
Query: 305 WDQCFYSQEQRQAF-----------------APFCAEDYTESLLQLHDAEIVRLKNYYEV 347
Q SQ+Q A + A+ + L+L + E+ N+
Sbjct: 1586 KSQ-VTSQQQEMAVLDRQLGHKKEELHLLQGSMVQAKADLQEALRLGETEVTEKCNHIRE 1644
Query: 348 HKELFE--GVQKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEE 405
K L E QK E ++ ERK + T + KEE+ + + + K + E
Sbjct: 1645 VKSLLEELSFQKGELNVQI---SERK----TQLTLIKQEIEKEEENLQVVLRQMSKHKTE 1697
Query: 406 LKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQ 457
LK +++ + E+ + + G K +++ E+ + + +++ +L+N +Q
Sbjct: 1698 LKNILDMLQLENHE---LQGLK-LQHDQRVSELEKTQVAVLEEKLELENLQQ 1745
Score = 32.7 bits (73), Expect = 0.91
Identities = 86/451 (19%), Positives = 183/451 (40%), Gaps = 59/451 (13%)
Query: 33 EDQRLQRTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG 92
+D + + K ++ LD+M + + L+ RL + +S KE + +E EG
Sbjct: 546 KDPKHSHMKAQKSGKEQQLDIMNKQYQQLESRLDEILSRIAKETEEIKD---LEEQLTEG 602
Query: 93 ETTILQ-LEKDLRTQVELMRK-------QKKERKQELKLLQEQDQELCEILCMPHYDIDS 144
+ + L+KDL + +++ Q + + E + L+++ + L + L + D
Sbjct: 603 QIAANEALKKDLEGVISGLQEYLGTIKGQATQAQNECRKLRDEKETLLQRLTEVEQERDQ 662
Query: 145 ASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCED 204
+ +++ N R+ + L + E S+++ +L + E + D
Sbjct: 663 LEIVAMDAENM-RKELAELESALQEQHEVNASLQQT----QGDLS-AYEAELEARLNLRD 716
Query: 205 EDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIM 264
+A L E L+K+ R ++++S +A E R ++ + Q EE+ + + +
Sbjct: 717 AEANQLKEE----LEKVTRLTQLEQSALQAELEKERQALKNALGKAQFSEEKEQENSEL- 771
Query: 265 SGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAE 324
AK+ K LQ + + L++ ++++ + + + LV+ + E R+ E
Sbjct: 772 ---HAKL-KHLQDDNNLLKQ-QLKDFQNHLNHVVDGLVRPEEVAARVDELRRKLKLGTGE 826
Query: 325 DYTESLLQLHDAEIVRLKNYYEVHKELFE--GVQKWEETWRLFLEFERKASDPNRFTNRG 382
+ +H V K+ ++ K+ E KWE ERK +
Sbjct: 827 ------MNIHSPSDVLGKSLADLQKQFSEILARSKWERDEAQVR--ERKLQEE------- 871
Query: 383 GNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKA---------FMVNGQKFMEYVA 433
L++EK ++ E L+AR+ +++H ++ K ME +
Sbjct: 872 -MALQQEKLATGQEEFRQACERALEARMNFDKRQHEARIQQMENEIHYLQENLKSMEEIQ 930
Query: 434 EQWEMHRLEKERAK-----QERQLKNKKQTE 459
++ E + K Q R+L+ KK+ E
Sbjct: 931 GLTDLQLQEADEEKERILAQLRELEKKKKLE 961
Score = 30.0 bits (66), Expect = 5.9
Identities = 42/158 (26%), Positives = 69/158 (43%), Gaps = 25/158 (15%)
Query: 4 SEVLAEESIVCL----QKALNHLREIWELIGIP-----EDQRLQR--TEVVKKHIKELLD 52
S +L E +V L Q + HLR + L G P + +R E V++ ++L
Sbjct: 222 SLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLERDLEK 281
Query: 53 MMIAEEE--SLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELM 110
MI EE S + R ++ I K +L E ++ E +L+ DL T+ EL+
Sbjct: 282 KMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCE------ELKSDLNTKNELL 335
Query: 111 RKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASVP 148
+++ E + + E +QEL Y ID+ P
Sbjct: 336 KQKTIELTRACQKQYELEQELA------FYKIDAKFEP 367
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 52.8 bits (125), Expect = 9e-07
Identities = 98/487 (20%), Positives = 200/487 (41%), Gaps = 55/487 (11%)
Query: 2 RRSEVLAEESIVCLQKALNHLREIWELIGIPEDQRLQRTEVVKK--HIKELLDMMIAEEE 59
+R E + E++ ++ + +++ W +G Q+ ++++ H + M E+
Sbjct: 137 KRQEKMNEKNYTFRKRVV--IKKPWLRLGEVTAQKRPENSLLEETLHFDHAVRMGTYIEK 194
Query: 60 SLKERLIKSISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQ 119
KER S+ + + NT+ E E E E L+L + +++++L K K + +
Sbjct: 195 LTKERDALSLELYR---NTITDEELKEKNAELQEK--LRLVESEKSEIQLNVKDLKRKLE 249
Query: 120 ELKLLQEQDQELCEILCM-PHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIK 178
+LL Q Q E + SA + + E N+ + +E K R+EE + +
Sbjct: 250 RAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQEEKMWRQEEKIQ-E 308
Query: 179 RQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQ-KLLRQLEMQKSQNEAVCE 237
++ +C +EL + + + E+ E I + K+ RQ E + Q E +
Sbjct: 309 QEEKMCEQELKIRE----QEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKI-- 362
Query: 238 GLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKALQLEVDRLEELKMQN--MKKVIE 295
R Q ++W + + E+ E + + K + E R E++ Q M++ E
Sbjct: 363 --REQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDE 420
Query: 296 AIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQLHDAEIVRLKNYYEVHKELFEGV 355
IR + + W Q E + +L + + + EV +++ E
Sbjct: 421 KIREQEEEMWRQ-------------------EEKIRELEEMMQDQEEKLREVEEKMQEEE 461
Query: 356 QKWEETWRLFLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLEEELKARIELWEQ 415
+K +E E K + T R LLK+E++ + ++ + + EE ++WEQ
Sbjct: 462 EKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEE------KMWEQ 515
Query: 416 EHSKAFMVNGQKFMEYVAEQWEMHRLEKERAKQERQLK--------NKKQTETEMLYGSA 467
E + E + E+ ++E QE++++ K + E+L G+
Sbjct: 516 EEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLGQKAELLGGAG 575
Query: 468 PRTPSKR 474
+ S+R
Sbjct: 576 RESGSQR 582
Score = 40.4 bits (93), Expect = 0.004
Identities = 75/395 (18%), Positives = 160/395 (40%), Gaps = 59/395 (14%)
Query: 112 KQKKERKQELKLLQEQ--DQELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKAS 169
+ K+ K+ LK + D E E + H +S V S F++ + E +
Sbjct: 94 EDSKQCKESLKRVTFTLPDDEAIEDAGVSHVKKNSDEVKS-----SFKKRQEKMNEKNYT 148
Query: 170 RREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQ---LE 226
R+ V K + L P+ S + + D ++ ++KL ++ L
Sbjct: 149 FRKRVVIKKPWLRLGEVTAQKRPENSLLEETLHFDH-----AVRMGTYIEKLTKERDALS 203
Query: 227 MQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGSKAKVRKA--------LQLE 278
++ +N E L+ + EL ++L++ E E+ + + K K+ +A LQ+E
Sbjct: 204 LELYRNTITDEELKEKNAELQEKLRLVESEKSEIQLNVKDLKRKLERAQLLLPQQQLQVE 263
Query: 279 VDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESL----LQLH 334
DRL + ++Q++ ++A +VE + W+ QE++ ++ E + L++
Sbjct: 264 ADRLGK-ELQSVSAKLQA-QVEENELWNLLNQQQEEKMWRQEEKIQEQEEKMCEQELKIR 321
Query: 335 DAEIVRLKNYYEVHKELFEGVQKWEETWRL---FLEFERKASDPNRFTNRGGNLLKEE-- 389
+ E + ++H++ + ++ ++ WR E E K + R ++E+
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQEEKIREQEEKIREQEEKMWRQEEKIREQDE 381
Query: 390 ----------KQRAKLQKMLPKLEEEL---------------KARIELWEQEHSKAFMVN 424
+Q K+++ K +E++ + E+W QE +
Sbjct: 382 KIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEE 441
Query: 425 GQKFMEYVAEQWEMHRLEKERAKQERQLKNKKQTE 459
+ E + E E+E QE++ K ++Q E
Sbjct: 442 MMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEE 476
Score = 37.0 bits (84), Expect = 0.048
Identities = 57/292 (19%), Positives = 135/292 (46%), Gaps = 39/292 (13%)
Query: 22 LREIWELIGIPEDQRLQRTEVVKKH---IKELLDMMIAEEESLKERLIKSISVCQKELNT 78
+RE E I E++ ++ E +++ I+E + M +EE ++E+ K ++
Sbjct: 355 IREQEEKIREQEEKMWRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQEKMWRQEKK 414
Query: 79 LCSELHVEPFQEEG----ETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEI 134
+ + QEE E I +LE+ ++ Q E +R+ +++ ++E + +QEQ++++
Sbjct: 415 MREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKI--- 471
Query: 135 LCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDT 194
Q ++ +E K R+E+ + + +I E++ +
Sbjct: 472 --------------------QRQEEKIQEQEEKTWRQEKLLKQEEKIWEQEEKMWRQEEK 511
Query: 195 SFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPE 254
+E++ ++++ E + ++ +R+ E++ Q E + +++EL +RL
Sbjct: 512 MWEQEEKMQEQE------EKMQRQEEKMREQEVRLWQQEEKMQEQEVRLQELEERLGKLG 565
Query: 255 EEREAV--ATIMSGSKAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQY 304
++ E + A SGS+ L+V+ L+ + Q++++ + R L QY
Sbjct: 566 QKAELLGGAGRESGSQRLPTLTPILQVE-LKSQEAQSLQQQQDHYRGHLQQY 616
>gi|81295809 pericentrin [Homo sapiens]
Length = 3336
Score = 52.8 bits (125), Expect = 9e-07
Identities = 103/399 (25%), Positives = 167/399 (41%), Gaps = 53/399 (13%)
Query: 23 REIWELIGIPEDQRLQRTEVVKKHIKELLDMMIAEEESLKER---LIKSISVCQKELNTL 79
R I+ + P +QR T K ++ ++ I + ES +E L +S +V EL L
Sbjct: 195 RGIFTISDHPAEQRGMFT----KECEQECELAITDLESGREDEAGLHQSQAVHGLELEAL 250
Query: 80 ---CSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERK-QELKLLQEQDQELCEIL 135
S +H E T L+K+ T + +R+ R+ QEL LLQ + Q E+L
Sbjct: 251 RLSLSNMHTAQL----ELTQANLQKEKETALTELREMLNSRRAQELALLQSRQQHELELL 306
Query: 136 CMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTS 195
H + E + + Q L+E S E+ QI+ ++E D
Sbjct: 307 REQH------AREKEEVVLRCGQEAAELKEKLQSEMEK----NAQIVKTLKE-----DWE 351
Query: 196 FERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEE 255
E+D L LEN+ Q EM+ QN+ E L Q EL Q +
Sbjct: 352 SEKD----------LCLENLRKELSAKHQSEMEDLQNQFQKE-LAEQRAELEKIFQDKNQ 400
Query: 256 EREAVATIMSGSKA---KVRKALQLEVDR-LEEL----KMQNMKKVIEAIRVELVQYWDQ 307
A+ + S +A K+R+ LQ E R LE+L K +K +E ++ Y D
Sbjct: 401 AERALRNLESHHQAAIEKLREDLQSEHGRCLEDLEFKFKESEKEKQLELENLQ-ASYEDL 459
Query: 308 CFYSQEQ-RQAFAPF-CAEDYTESLLQLHDAEIVRLKNYYEVHK-ELFEGVQKWEETWRL 364
SQE+ R+ ++ A + L +LH+ + R ++ + + E Q E +L
Sbjct: 460 KAQSQEEIRRLWSQLDSARTSRQELSELHEQLLARTSRVEDLEQLKQREKTQHESELEQL 519
Query: 365 FLEFERKASDPNRFTNRGGNLLKEEKQRAKLQKMLPKLE 403
+ FE+K D + LL++ Q A+ +L +E
Sbjct: 520 RIYFEKKLRDAEKTYQEDLTLLQQRLQGAREDALLDSVE 558
Score = 39.3 bits (90), Expect = 0.010
Identities = 63/276 (22%), Positives = 114/276 (41%), Gaps = 41/276 (14%)
Query: 206 DAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMS 265
+A LSL N+ T Q L Q +QK + A+ T++RE+ + + +A + S
Sbjct: 248 EALRLSLSNMHTAQLELTQANLQKEKETAL-----TELREM-----LNSRRAQELALLQS 297
Query: 266 GSKAKVRKALQLEVDRLEELKM---QNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFC 322
+ ++ + EE+ + Q ++ E ++ E+ + +E ++ C
Sbjct: 298 RQQHELELLREQHAREKEEVVLRCGQEAAELKEKLQSEMEKNAQIVKTLKEDWESEKDLC 357
Query: 323 AEDYTESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRG 382
E+ + L H +E+ L+N ++ KEL E Q+ E E+ D N+
Sbjct: 358 LENLRKELSAKHQSEMEDLQNQFQ--KELAE--QR--------AELEKIFQDKNQAERAL 405
Query: 383 GNLLKEEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLE 442
NL + Q + KL E+L + EH + KF E +E+ + LE
Sbjct: 406 RNL------ESHHQAAIEKLREDL-------QSEHGRCLEDLEFKFKE--SEKEKQLELE 450
Query: 443 KERAKQERQLKNKKQTETEMLYGSAPRTPSKRRGLA 478
+A E LK + Q E L+ + R+ L+
Sbjct: 451 NLQASYE-DLKAQSQEEIRRLWSQLDSARTSRQELS 485
Score = 39.3 bits (90), Expect = 0.010
Identities = 97/425 (22%), Positives = 156/425 (36%), Gaps = 96/425 (22%)
Query: 39 RTEVVKKHIKELLDMMIAEEESLKERLIKSISVCQKELNTLCSELHVEPFQEEG------ 92
R ++K +++L E+ +++ K S ++ L SEL + Q G
Sbjct: 1403 REAALRKEVEDLTK----EQSETRKQAEKDRSALLSQMKILESELEEQLSQHRGCAKQAE 1458
Query: 93 -----ETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQDQELCEILCMPHYDIDSASV 147
E + L+K LR Q + M +Q ER+ E + Q++ Q L
Sbjct: 1459 AVTALEQQVASLDKHLRNQRQFMDEQAAEREHEREEFQQEIQRL---------------- 1502
Query: 148 PSLEELNQFRQHVTTLRETKASRREEFVSIKRQIILCMEELDHTPDTSFERDVVCEDEDA 207
Q RQ + R + + ++ L ++L D E + E D
Sbjct: 1503 -----EGQLRQ--AAKPQPWGPRDSQQAPLDGEVELLQQKLREKLDEFNELAIQKESAD- 1554
Query: 208 FCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRTQIRELWDRLQIPEEEREAVATIMSGS 267
RQ+ MQ+ + + + E + IR+ +LQ EE E I+ G
Sbjct: 1555 ---------------RQVLMQEEEIKRL-EEMNINIRKKVAQLQ---EEVEKQKNIVKG- 1594
Query: 268 KAKVRKALQLEVDRLEELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYT 327
LE D+ E LK Q M ++ A ++ +C P + T
Sbjct: 1595 ---------LEQDK-EVLKKQQMSSLLLASTLQSTLDAGRCPEPPSGSPPEGPEIQLEVT 1644
Query: 328 ESLLQLHDAEIVRLKNYYEVHKELFEGVQKWEETWRLFLEFERKASDPNRFTNRGGNLLK 387
+ L ++E++ LK E K E K EE L L+ + + N T L+
Sbjct: 1645 QRALLRRESEVLDLKEQLEKMKGDLE--SKNEEILHLNLKLDMQ----NSQTAVSLRELE 1698
Query: 388 EEKQRAKLQKMLPKLEEELKARIELWEQEHSKAFMVNGQKFMEYVAEQWEMHRLEKERAK 447
EE K+ EELKA IE QE+ K RL+KE+A+
Sbjct: 1699 EENTSLKVIYTRSSEIEELKATIENL-QENQK--------------------RLQKEKAE 1737
Query: 448 QERQL 452
+ QL
Sbjct: 1738 EIEQL 1742
>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
[Homo sapiens]
Length = 1354
Score = 52.4 bits (124), Expect = 1e-06
Identities = 111/501 (22%), Positives = 204/501 (40%), Gaps = 102/501 (20%)
Query: 12 IVCLQKALNHLREIWELIGIPEDQRLQRTEVVKKHIKELLDMMIA---EEESLKERLIKS 68
I LQ+ + HL+ E + E +R + +++ KE ++ I + +SL++RL +
Sbjct: 631 ITSLQEEVKHLKHNLEKV---EGERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQE 687
Query: 69 ISVCQKELNTLCSELHVEPFQEEGETTILQLEKDLRTQVELMRKQKKERKQELKLLQEQD 128
++ K ++ H + +E + ++EK L K+++E +++ + Q
Sbjct: 688 VNE-HKVTKARLTDKH-QSIEEAKSVAMCEMEKKL--------KEEREAREKAENRVVQI 737
Query: 129 QELCEILCMPHYDIDSASVPSLEELNQFRQHVTTLRETKASRREEFVSIKRQI------- 181
++ C +L D+D L Q +Q + L K +E ++ Q+
Sbjct: 738 EKQCSML-----DVD---------LKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKR 783
Query: 182 ILCMEELDHTPDTSFERDVVCEDEDAFCLSLENIATLQKLLRQLEMQKSQNEAVCEGLRT 241
+L EL +FE D + E + I TL + R LE + +Q G
Sbjct: 784 LLLQNELK---TQAFEADNLKGLEKQM---KQEINTLLEAKRLLEFELAQLTKQYRGNEG 837
Query: 242 QIRELWDRL-------------------QIPEEEREAVATIMSGSKAKVRKALQLEVDRL 282
Q+REL D+L +I E+ RE + I K A QL++
Sbjct: 838 QMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNEKETLATQLDLAET 897
Query: 283 EELKMQNMKKVIEAIRVELVQYWDQCFYSQEQRQAFAPFCAEDYTESLLQ------LHDA 336
+ Q + ++E EL Q + + RQ +D+T S L+ D
Sbjct: 898 KAESEQLARGLLEEQYFELTQESKKA--ASRNRQEITD---KDHTVSRLEEANSMLTKDI 952
Query: 337 EIVRLKNYYEVHKELFEGVQKWEETWRLFLE---------FERKASDPNRFTNRGGNLLK 387
EI+R +N +EL E ++K EE ++L E FE+ + + N L
Sbjct: 953 EILRREN-----EELTEKMKKAEEEYKLEKEEEISNLKAAFEKNINTERTLKTQAVNKLA 1007
Query: 388 E---------EKQRAKLQKMLPKLEEELKARIEL-WEQEHSKAFMVNGQKFM-----EYV 432
E ++++A Q + K +E K ++EL E+E +V QK + + V
Sbjct: 1008 EIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV 1067
Query: 433 AEQWEMHRLEKERAKQERQLK 453
E + L+ + A +E ++
Sbjct: 1068 EECAHRNELQMQLASKESDIE 1088
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.130 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,309,078
Number of Sequences: 37866
Number of extensions: 985674
Number of successful extensions: 9048
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 77
Number of HSP's successfully gapped in prelim test: 578
Number of HSP's that attempted gapping in prelim test: 6451
Number of HSP's gapped (non-prelim): 2139
length of query: 566
length of database: 18,247,518
effective HSP length: 108
effective length of query: 458
effective length of database: 14,157,990
effective search space: 6484359420
effective search space used: 6484359420
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.