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Search of human proteins with 40806187
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40806187 ADAM metallopeptidase with thrombospondin type 1
motif, 18 preproprotein [Homo sapiens]
(1221 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 2606 0.0
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 1462 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 801 0.0
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 698 0.0
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 656 0.0
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 645 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 596 e-170
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 552 e-157
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 543 e-154
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 535 e-152
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 535 e-151
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 514 e-145
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 496 e-140
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 493 e-139
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 463 e-130
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 460 e-129
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 405 e-113
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 402 e-111
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 402 e-111
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 374 e-103
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 372 e-102
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 361 3e-99
gi|145309328 papilin [Homo sapiens] 342 2e-93
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 339 8e-93
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 316 8e-86
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 290 8e-78
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 286 8e-77
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 275 1e-73
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 236 8e-62
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 236 1e-61
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 2606 bits (6755), Expect = 0.0
Identities = 1221/1221 (100%), Positives = 1221/1221 (100%)
Query: 1 MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD 60
MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD
Sbjct: 1 MECALLLACAFPAAGSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDD 60
Query: 61 YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS 120
YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS
Sbjct: 61 YVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSS 120
Query: 121 HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP 180
HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP
Sbjct: 121 HFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISP 180
Query: 181 LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE 240
LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE
Sbjct: 181 LPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRE 240
Query: 241 TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV 300
TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV
Sbjct: 241 TEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVV 300
Query: 301 ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH 360
ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH
Sbjct: 301 ADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHH 360
Query: 361 ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC 420
ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC
Sbjct: 361 ADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC 420
Query: 421 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ 480
TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ
Sbjct: 421 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNGVFSWSSCSRQ 480
Query: 481 YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI 540
YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI
Sbjct: 481 YLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDI 540
Query: 541 CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE 600
CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE
Sbjct: 541 CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSE 600
Query: 601 CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS 660
CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS
Sbjct: 601 CSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNS 660
Query: 661 KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC 720
KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC
Sbjct: 661 KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVC 720
Query: 721 ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ 780
ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ
Sbjct: 721 ELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQ 780
Query: 781 ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET 840
ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET
Sbjct: 781 ELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET 840
Query: 841 LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC 900
LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC
Sbjct: 841 LVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAIC 900
Query: 901 LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ 960
LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ
Sbjct: 901 LRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQ 960
Query: 961 KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG 1020
KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG
Sbjct: 961 KKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG 1020
Query: 1021 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS 1080
SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS
Sbjct: 1021 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS 1080
Query: 1081 EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG 1140
EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG
Sbjct: 1081 EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG 1140
Query: 1141 GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ 1200
GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ
Sbjct: 1141 GGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQ 1200
Query: 1201 HGVCNHKFYGKQCCKSCTRKI 1221
HGVCNHKFYGKQCCKSCTRKI
Sbjct: 1201 HGVCNHKFYGKQCCKSCTRKI 1221
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 1462 bits (3785), Expect = 0.0
Identities = 690/1238 (55%), Positives = 866/1238 (69%), Gaps = 63/1238 (5%)
Query: 20 RGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGL----------NDDYVFVTPVEV 69
RGLA L + + CA AA A S S +Y V+ EV
Sbjct: 9 RGLAALWMLLAQVAEQAPACAMGPAAAAPGSPSVPRPPPPAERPGWMEKGEYDLVSAYEV 68
Query: 70 DSAGSYISHDILHNGRKKRSAQNAR-SSLHYRFSAFGQELHLELKPSA-ILSSHFIVQVL 127
D G Y+SH+I+H+ R++R+ + SLH R + H++L+ S+ +++ FIVQ L
Sbjct: 69 DHRGDYVSHEIMHHQRRRRAVPVSEVESLHLRLKGSRHDFHMDLRTSSSLVAPGFIVQTL 128
Query: 128 GKDGASETQK-PEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLA 186
GK G Q P CFYQG +R+ +SSVA+STC GLSG+IRT + ++ + PLP L+
Sbjct: 129 GKTGTKSVQTLPPEDFCFYQGSLRSHRNSSVALSTCQGLSGMIRTEEADYFLRPLPSHLS 188
Query: 187 QEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQ----SRETE 242
+ ++ HVLYKR+ E H P AS+ SR E
Sbjct: 189 WKLGRAAQGSSPSHVLYKRSTE---------------------PHAPGASEVLVTSRTWE 227
Query: 243 YHHRRL----------QKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKG 292
H+ L QKQHFCGRRKKY P+PP ED ++ DEY S R +RS +S +
Sbjct: 228 LAHQPLHSSDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRN 287
Query: 293 --LNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQ 350
LNVETLVV DKKM++ HG N+TTY+LT++NMVS LFKDGTIG +IN+ +V LILLE
Sbjct: 288 EELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLED 347
Query: 351 EPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPI 410
E GL+I+HHAD +L+SFCQWQS L+GK+G RHDHAILLTG DICSWKNEPCDTLGFAPI
Sbjct: 348 EQPGLVISHHADHTLSSFCQWQSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPI 407
Query: 411 SGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNNG 470
SGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGN C+K+EGNIMSPTL G NG
Sbjct: 408 SGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKKSEGNIMSPTLAGRNG 467
Query: 471 VFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAK 530
VFSWS CSRQYL KFLST QA CL D+PK +YKYP+KLPG++YDA+TQCKWQFG KAK
Sbjct: 468 VFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAK 527
Query: 531 LCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHG 590
LC L F KDICK+LWCHR+G +CETKFMPAAEGT+CG MWCR GQCVK+G+ GP+P HG
Sbjct: 528 LCMLDFKKDICKALWCHRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHG 587
Query: 591 QWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDF 650
WS WS WS CSRTCGGGV + R C NPKP +GG FC GS+R +LCN C +S+DF
Sbjct: 588 HWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDF 647
Query: 651 RAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPN 710
RA QCAE+NS+ FRG Y+WKPYT+VE++D CKLYC AE F+FFF++S KVKDGTPCS +
Sbjct: 648 RAAQCAEHNSRRFRGRHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCSED 707
Query: 711 KNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLI 770
+VCIDG+CE VGCD+ LGS AV D CGVC G+NS C ++GLY H N+YY +V I
Sbjct: 708 SRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTI 767
Query: 771 PAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPER 830
P+GARSI I E+ VS+SY++VR+ ++YYL G W++DWPG + F+GTTF+Y+RS+N PE
Sbjct: 768 PSGARSIRIYEMNVSTSYISVRNALRRYYLNGHWTVDWPGRYKFSGTTFDYRRSYNEPEN 827
Query: 831 LYAPGPTNETLVFEILMQGKNPGIAWKYALPKV-MNGTPPATKRPAYTWSIVQSECSVSC 889
L A GPTNETL+ E+L QG+NPG+AW+Y++P++ PPA +P+YTW+IV+SECSVSC
Sbjct: 828 LIATGPTNETLIVELLFQGRNPGVAWEYSMPRLGTEKQPPA--QPSYTWAIVRSECSVSC 885
Query: 890 GGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAG 949
GGG + V+ C RD QVN SFC+ KT+PVT C +CP W G WS CS+ C G
Sbjct: 886 GGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGG 945
Query: 950 GQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGR 1009
G QSR +QC ++ + E V SLCP P+ QACNS +CPP WS GPW++CS TCG+
Sbjct: 946 GAQSRPVQCTRRVHYD-SEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGK 1004
Query: 1010 GVRKRELLCK----GSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECS 1065
G RKR + CK + A+ LP++ CTS P+P + E C+L RC K +LQW+ S+WS+CS
Sbjct: 1005 GWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCS 1064
Query: 1066 ATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMV- 1124
TC G +KR +KC+EK GK ++C ++ KP+L+LE C CP HP +
Sbjct: 1065 VTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAG 1124
Query: 1125 ---AGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPAPE 1181
W++ PW QCT +CGGGVQTRSV C+ GRP+S CLLHQKP ACNT+FCP E
Sbjct: 1125 PSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPIAE 1184
Query: 1182 KREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTR 1219
K+ D C D+F+WC+LVPQHG+C+HKFYGKQCCK+C++
Sbjct: 1185 KK-DAFCKDYFHWCYLVPQHGMCSHKFYGKQCCKTCSK 1221
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 801 bits (2068), Expect = 0.0
Identities = 417/1050 (39%), Positives = 604/1050 (57%), Gaps = 73/1050 (6%)
Query: 59 DDYVFVTPVEVDSAGSYISHDILHN--GRKKRSA-----QNARSSLHYRFSAFGQELHLE 111
+ Y P+ VD G+++S + ++ R++RS Q A S L ++ SA+G+ HL
Sbjct: 40 EHYQLTIPIRVDQNGAFLSFTVKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLN 99
Query: 112 LKPSA-ILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRND-SSSSVAVSTCAGLSGLI 169
L + +S HF V+ GKDG + + + C Y G++++ S++ VA+S C GL G+I
Sbjct: 100 LTLNTDFVSKHFTVEYWGKDGP-QWKHDFLDNCHYTGYLQDQRSTTKVALSNCVGLHGVI 158
Query: 170 RTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSP 229
T E+ I PL ++S GH PHV+YK++A +Q+ Y S ++
Sbjct: 159 ATEDEEYFIEPLKNTTEDSKHFSYENGH-PHVIYKKSA---LQQRHLYDHSHCGVSDFTR 214
Query: 230 SHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKS 289
S P T + + H R+K+ + RF
Sbjct: 215 SGKPWWLNDTSTVSYSLPINNTHIHHRQKRSV-------SIERF---------------- 251
Query: 290 QKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLE 349
VETLVVADK MV HG+ ++ YIL+VMN+V+ L++D ++G+ +N++V LI+L
Sbjct: 252 -----VETLVVADKMMVGYHGRKDIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLT 306
Query: 350 QEPGGLLINHHADQSLNSFCQWQSALIG---------KNG-KRHDHAILLTGFDICSWKN 399
++ L INHHAD+SL+SFC+WQ +++ +NG HD+A+L+T +DIC++KN
Sbjct: 307 EDQPNLEINHHADKSLDSFCKWQKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKN 366
Query: 400 EPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKA--- 456
+PC TLG A ++GMC RSC+INED GLG AFTIAHE GHNFGM HDG GN C
Sbjct: 367 KPCGTLGLASVAGMCEPERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHE 426
Query: 457 EGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYD 516
+M+ +T N FSWS+CSR Y+ FL + + CL +EP + + YP PGQ+YD
Sbjct: 427 AAKLMAAHITANTNPFSWSACSRDYITSFLDSGRGTCLDNEPPKR-DFLYPAVAPGQVYD 485
Query: 517 ADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSM----WC 572
AD QC++Q+GA ++ C G ++C+ LWC +RC T +PAAEGT+C WC
Sbjct: 486 ADEQCRFQYGATSRQCKYG---EVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWC 542
Query: 573 RQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSS 632
QG CV FG P+ I G W WS W ECSRTCGGGV RHC++P P GG +C G
Sbjct: 543 YQGDCVPFGTW-PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGER 601
Query: 633 RIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFE 692
+ Y+ CN +PC S DFR +QCA++++ PFRG +Y WKPYT + C L C AE +
Sbjct: 602 KRYRSCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYTGGGVKP-CALNCLAEGYN 660
Query: 693 FFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYK 752
F+ + V DGT C+ + D+CI+G C+ VGCD+ LGS A D C VC GD STC +
Sbjct: 661 FYTERAPAVIDGTQCNADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIE 720
Query: 753 GLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEF 812
G + + Y VV IP G+ IE++E+ +S +Y+A++S YY+ G W+IDWP +F
Sbjct: 721 GFFNDSLPRGGYMEVVQIPRGSVHIEVREVAMSKNYIALKSEGDDYYINGAWTIDWPRKF 780
Query: 813 PFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATK 872
AGT F Y+R + PE L A GPT+E L+ +L+Q +N GI +K+ +P G+
Sbjct: 781 DVAGTAFHYKRPTDEPESLEALGPTSENLIVMVLLQEQNLGIRYKFNVPITRTGS--GDN 838
Query: 873 RPAYTWSIVQ-SECSVSCGGGYINVKAICLR-DQNTQVNSSFCSAKTKPVTEPKICNAFS 930
+TW+ SECS +C GG + +C R D N+ V +++C +KP + CN
Sbjct: 839 EVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEP 898
Query: 931 CPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHA 990
CP W G+W CSK C GG ++R + C++K +EE + +S C P + + CN+ +
Sbjct: 899 CPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQS 958
Query: 991 CPPQWSLGPWSQCSKTCGRGVRKRELLCKGS-AAETLPESQCTSLPRPELQEGCVLGRCP 1049
CPPQW WS+C+ CG G + R +LCK S ++T P +QC +P ++ C LGRCP
Sbjct: 959 CPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCP 1018
Query: 1050 KNSRLQWVASSWSECSATCGLGVRKREMKC 1079
+WV W +CSA CGLG + R ++C
Sbjct: 1019 PP---RWVTGDWGQCSAQCGLGQQMRTVQC 1045
Score = 71.6 bits (174), Expect = 4e-12
Identities = 44/130 (33%), Positives = 60/130 (46%), Gaps = 20/130 (15%)
Query: 1056 WVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRAC 1115
W WSECSATC GV+++E+ C K I C KP + + CN C
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVC--KRLDDNSIV-QNNYCDPDSKPP-ENQRACNTEPC 899
Query: 1116 PAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPS-------SSCLLHQKPPV 1168
P W+ W +C+ TC GG++TR+V C+++ PS S CL H +P
Sbjct: 900 PPE--------WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTH-RPVE 950
Query: 1169 LRACNTNFCP 1178
CN CP
Sbjct: 951 KEPCNNQSCP 960
Score = 52.4 bits (124), Expect = 3e-06
Identities = 31/110 (28%), Positives = 54/110 (49%), Gaps = 8/110 (7%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKI---CNAFSCPA-YWMPG 938
SEC+ CG G+ + +C +++ ++ +F +A+ ++P + C+ CP W+ G
Sbjct: 969 SECTPKCGPGFKHRIVLC---KSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTG 1025
Query: 939 EWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNS 988
+W CS C GQQ R +QC+ Q L ++ P S C+S
Sbjct: 1026 DWGQCSAQCGLGQQMRTVQCLSYTG-QASSDCLETVRPPSMQQCESKCDS 1074
Score = 43.1 bits (100), Expect = 0.002
Identities = 40/137 (29%), Positives = 60/137 (43%), Gaps = 13/137 (9%)
Query: 1065 SATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVY--N 1122
S C G RE+ C K + + P + N++ + C + C + +
Sbjct: 498 SRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIE-KGWCYQGDCVPFGTWPQS 556
Query: 1123 MVAGW--YSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSS---CLLHQKPPVLRACNTNFC 1177
+ GW +SL W +C+ TCGGGV + HC PS CL +K R+CNT+ C
Sbjct: 557 IDGGWGPWSL-WGECSRTCGGGVSSSLRHC-DSPAPSGGGKYCLGERKR--YRSCNTDPC 612
Query: 1178 PAPEKR-EDPSCVDFFN 1193
P + + C DF N
Sbjct: 613 PLGSRDFREKQCADFDN 629
Score = 41.6 bits (96), Expect = 0.005
Identities = 59/243 (24%), Positives = 91/243 (37%), Gaps = 50/243 (20%)
Query: 937 PGEWSTCSKA-CAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQW 995
P WS CS+ S + C+ +P +++ L P P QV + C Q+
Sbjct: 441 PFSWSACSRDYITSFLDSGRGTCLDNEPPKRD-----FLYPAVAPGQVYDADEQ-CRFQY 494
Query: 996 SLGPWSQCSKTCGRGVRKRELLCKGSA----AETLPESQCTSLPRPELQEG-CVLGRC-- 1048
S+ C G REL C + ++P ++ T +++G C G C
Sbjct: 495 GA-----TSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVP 549
Query: 1049 ----PKNSRLQWVA-SSWSECSATCGLGVRKREMKCSEKGFQ--GKLITFPERRCRNIKK 1101
P++ W S W ECS TCG GV C GK +R R
Sbjct: 550 FGTWPQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYR---- 605
Query: 1102 PNLDLEETCNRRACPAHP---VYNMVAGWYSLP-------WQQCTVTCGGGVQTRSVHCV 1151
+CN CP A + ++P W+ T GGGV+ +++C+
Sbjct: 606 -------SCNTDPCPLGSRDFREKQCADFDNMPFRGKYYNWKPYT---GGGVKPCALNCL 655
Query: 1152 QQG 1154
+G
Sbjct: 656 AEG 658
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 698 bits (1801), Expect = 0.0
Identities = 392/1047 (37%), Positives = 565/1047 (53%), Gaps = 77/1047 (7%)
Query: 59 DDYVFVTPVEVDSAGSYISHDILHNGRKKR-SAQNARSSLHYRFSAFGQELHLEL-KPSA 116
+ Y P VD G+ ++ R++R + A S L Y+ ++ L L + S
Sbjct: 37 ESYEIAFPTRVDHNGALLAFSPPPPRRQRRGTGATAESRLFYKVASPSTHFLLNLTRSSR 96
Query: 117 ILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSS-VAVSTCAGLSGLIRTRKNE 175
+L+ H V+ ++G + Q+ C Y G ++ +S+S VA+STC GL GLI + E
Sbjct: 97 LLAGHVSVEYWTREGLA-WQRAARPHCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEE 155
Query: 176 FLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHA 235
+LI PL SP PHV+YKR S +P H+ A
Sbjct: 156 YLIEPLH---GGPKGSRSPEESGPHVVYKR--------------SSLRHP-----HLDTA 193
Query: 236 SQSRETEYHHRRLQKQHFCGRRKKYAP-KPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLN 294
R+ ++ + GR KPP E G G +RS + +
Sbjct: 194 CGVRD---------EKPWKGRPWWLRTLKPPPARPLGNETERGQPGL-KRSVSRERY--- 240
Query: 295 VETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGG 354
VETLVVADK MV HG+ +V Y+L +MN+V+ LF+D ++GS +N++V LILL ++
Sbjct: 241 VETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLTEDQPT 300
Query: 355 LLINHHADQSLNSFCQWQSALIGKNGK----------RHDHAILLTGFDICSWKNEPCDT 404
L I HHA +SL+SFC+WQ +++ +G HD A+L+T +DIC +KN+PC T
Sbjct: 301 LEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPCGT 360
Query: 405 LGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCR---KAEGNIM 461
LG AP+ GMC + RSC++NED GL AFTIAHE GH FGM HDG GN C + +M
Sbjct: 361 LGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAKLM 420
Query: 462 SPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQC 521
+ +T F WSSCSR Y+ FL + CL + P + + YP PGQ YDAD QC
Sbjct: 421 AAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQ-DFVYPTVAPGQAYDADEQC 479
Query: 522 KWQFGAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSM----WCRQGQC 577
++Q G K++ C G ++C LWC +RC T +PAAEGT+C WC + C
Sbjct: 480 RFQHGVKSRQCKYG---EVCSELWCLSKSNRCITNSIPAAEGTLCQTHTIDKGWCYKRVC 536
Query: 578 VKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQL 637
V FG P + G W W+ W +CSRTCGGGV RHC++P+P GG +C G R ++
Sbjct: 537 VPFGSR-PEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRHRS 595
Query: 638 CNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAM 697
CN + C S DFR QC+E++S PFRG FY+WK Y + C L C AE F F+
Sbjct: 596 CNTDDCPPGSQDFREVQCSEFDSIPFRGKFYKWKTY-RGGGVKACSLTCLAEGFNFYTER 654
Query: 698 SGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLN 757
+ V DGTPC P+ D+C+ G C+ VGCD LGS D C VC GD S C+ +G++
Sbjct: 655 AAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEGVFSP 714
Query: 758 QHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGT 817
Y VV IP G+ I IQ+L +S S+LA++ + L G P P AGT
Sbjct: 715 ASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQESLLLEGLPGTPQPHRLPLAGT 774
Query: 818 TFEYQRSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYT 877
TF+ ++ ++ + L A GP N +L+ +L + + P + +++ P + PP Y+
Sbjct: 775 TFQLRQGPDQVQSLEALGPINASLIVMVLARTELPALRYRFNAPIARDSLPP------YS 828
Query: 878 WSIVQ-SECSVSCGGGYINVKAICLRDQ--NTQVNSSFCSAKTKPVTEPKICNAFSCPAY 934
W ++CS C GG V+A+ R+Q ++ V +CSA +K + CN CP
Sbjct: 829 WHYAPWTKCSAQCAGG-SQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPD 887
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQ 994
W+ G WS CS++C G +SR + C ++ +E+A+ S CP P ++AC+ CPP+
Sbjct: 888 WVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTCPPE 947
Query: 995 WSLGPWSQCSKTCGRGVRKRELLCKGS-AAETLPESQCTSLPRPELQEGCVLGRCPKNSR 1053
W+ WS+C+ +CG G+R R +LCK + TLP + C+ +P C L RCP
Sbjct: 948 WAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCPP--- 1004
Query: 1054 LQWVASSWSECSATCGLGVRKREMKCS 1080
+WVA W ECSA CG+G R+R ++C+
Sbjct: 1005 ARWVAGEWGECSAQCGVGQRQRSVRCT 1031
Score = 167 bits (422), Expect = 7e-41
Identities = 101/299 (33%), Positives = 141/299 (47%), Gaps = 32/299 (10%)
Query: 930 SCPAY-WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST--PTQVQAC 986
S P Y W W+ CS CAGG Q + ++C + AV C + P + +AC
Sbjct: 823 SLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLD---SSAVAPHYCSAHSKLPKRQRAC 879
Query: 987 NSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG--SAAE--TLPESQCTSLPRPELQEG 1042
N+ CPP W +G WS CS++C GVR R ++C+ SAAE L +S C PRP + E
Sbjct: 880 NTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEA 938
Query: 1043 CVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP 1102
C CP +W A WSEC+ +CG G+R R + C + T P C KP
Sbjct: 939 CHGPTCPP----EWAALDWSECTPSCGPGLRHRVVLCKSADHRA---TLPPAHCSPAAKP 991
Query: 1103 NLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ-GRPSSSCL 1161
+ CN R CP A W + W +C+ CG G + RSV C G+ S C
Sbjct: 992 PATMR--CNLRRCPP-------ARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECT 1042
Query: 1162 LHQKPPVLRACNTNFCPAPEKREDP-SCVDF--FNWCHLVPQHGVCNHKFYGKQCCKSC 1217
+PP + C C +P + P C D +C LV + C+ ++ + CCK+C
Sbjct: 1043 EALRPPTTQQCEAK-CDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
Score = 41.2 bits (95), Expect = 0.006
Identities = 22/51 (43%), Positives = 29/51 (56%), Gaps = 6/51 (11%)
Query: 1131 PWQQCTVTCGGGVQTRSVHCVQQGRPS---SSCLLHQKPPVLRACNTNFCP 1178
PW C+ TCGGGV + S HC RP+ CL ++ R+CNT+ CP
Sbjct: 555 PWGDCSRTCGGGVSSSSRHC-DSPRPTIGGKYCLGERRRH--RSCNTDDCP 602
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 656 bits (1693), Expect = 0.0
Identities = 375/1016 (36%), Positives = 552/1016 (54%), Gaps = 85/1016 (8%)
Query: 60 DYVFVTPVEVDSAGSYISHDI---LHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPS- 115
+Y V PV VD++G ++S+ + + + R+KR + ++YR S ++L L +
Sbjct: 51 EYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDWVYYRISHEEKDLFFNLTVNQ 110
Query: 116 AILSSHFIVQV-LGKDGASETQKPEVQQCFYQGFIRNDSS--SSVAVSTCAGLSGLIRTR 172
LS+ +I++ G + C G + + + A+S C GL+G +
Sbjct: 111 GFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTAALSACHGLTGFFQLP 170
Query: 173 KNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHI 232
+F I P+ + E G+HPH++Y+R +
Sbjct: 171 HGDFFIEPVKKHPLVE------GGYHPHIVYRR------------------------QKV 200
Query: 233 PHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRP--RRSAGKSQ 290
P K+ CG + E +++ + R RRS K +
Sbjct: 201 PET--------------KEPTCGLKDSVNISQKQELWREKWERHNLPSRSLSRRSISKER 246
Query: 291 KGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQ 350
VETLVVAD KM+E HG NV +YILT+MNMV+GLF + +IG+ I++VVV LILLE+
Sbjct: 247 W---VETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEE 303
Query: 351 EPGGLLINHHADQSLNSFCQWQSALIGK---NGKRHDHAILLTGFDICSWKNEPCDTLGF 407
E GL I HHA+++L+SFC+WQ ++ K N HD A+LLT DIC+ N PC+TLG
Sbjct: 304 EEQGLKIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGL 363
Query: 408 APISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGN--IMSPTL 465
+ +SGMC +RSC INED+GL LAFTIAHE GH+FG+ HDG+ N C + IMS L
Sbjct: 364 SHLSGMCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQL 423
Query: 466 TGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQF 525
+ +WS CS +Y+ +FL CL D PK+ G K PG IYD QC+ Q+
Sbjct: 424 QYDPTPLTWSKCSEEYITRFLDRGWGFCLDDIPKKKG-LKSKVIAPGVIYDVHHQCQLQY 482
Query: 526 GAKAKLCSLGFVKDICKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGP 585
G A C V+++C++LWC G C +K AA+GT CG WC G+C+ G+ P
Sbjct: 483 GPNATFCQE--VENVCQTLWCSVKGF-CRSKLDAAADGTQCGEKKWCMAGKCITVGKK-P 538
Query: 586 RPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNE 645
I G W WS WS CSRTCG GV+ ER CNNP+P++GG +C G + Y+LCN++PC
Sbjct: 539 ESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRS 598
Query: 646 NSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGT 705
+ FR QC+E+++ P++ Y W P C+LYC+ + +F M V DGT
Sbjct: 599 EAPTFRQMQCSEFDTVPYKNELYHWFPI--FNPAHPCELYCRPIDGQFSEKMLDAVIDGT 656
Query: 706 PC--SPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANE 763
PC N +VCI+G+C++VGCD+E+ S A D CGVC GD S+C+ + ++ Q + +
Sbjct: 657 PCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMF-KQKEGSG 715
Query: 764 YYPVVLIPAGARSIEIQELQVSSSYLAVRSLS-QKYYLTGGWSIDWPGEFPFAGTTFEYQ 822
Y + LIP GAR I + E++ + ++LA+RS +KYYL GG+ I W G + AGT F+Y
Sbjct: 716 YVDIGLIPKGARDIRVMEIEGAGNFLAIRSEDPEKYYLNGGFIIQWNGNYKLAGTVFQYD 775
Query: 823 RSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ 882
R + E+L A GPTNE++ ++L Q NPGI ++Y + K +G ++ Y W
Sbjct: 776 RKGDL-EKLMATGPTNESVWIQLLFQVTNPGIKYEYTIQK--DGLDNDVEQQMYFWQYGH 832
Query: 883 -SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWS 941
+ECSV+CG G A C++ V ++FC +T+P K C+ +CP W GEW
Sbjct: 833 WTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWE 892
Query: 942 TCSKACA-GGQQSRKIQCVQKKPFQKEEAVLHSLCP-VSTPTQVQACNSH-ACPPQWSLG 998
CS C G++ R + C+Q E+A+ + C + P + +CN CP W++G
Sbjct: 893 ACSATCGPHGEKKRTVLCIQTM-VSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVG 951
Query: 999 PWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRL 1054
WS+CS +CG GVR R + C + E C +P + C L +CP + R+
Sbjct: 952 NWSECSVSCGGGVRIRSVTCAKNHDE-----PCDVTRKPNSRALCGLQQCPSSRRV 1002
Score = 110 bits (276), Expect = 6e-24
Identities = 82/298 (27%), Positives = 117/298 (39%), Gaps = 54/298 (18%)
Query: 933 AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCP-VSTPTQVQACNSHAC 991
A+W+ G WS CS C G R+++C + + S C + P + C+ C
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQ---------MDSDCAAIQRPDPAKRCHLRPC 1365
Query: 992 PPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAE-TLPESQCTSLPR--PELQEGCVLGRC 1048
W +G WS+CS+ C G + RE+ C S L C L P L C C
Sbjct: 1366 AG-WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC 1424
Query: 1049 PKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEE 1108
W WS+CS +CG GV++R + C P C K+P +
Sbjct: 1425 EA-----WQVEPWSQCSRSCGGGVQERGVFC------------PGGLCDWTKRPTSTM-- 1465
Query: 1109 TCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV----QQGRPSSSCLLHQ 1164
+CN C W + W C+ +CGGG Q R+V CV + CL
Sbjct: 1466 SCNEHLC---------CHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDH 1516
Query: 1165 K--PPVLRACNTNFCPAPEKREDPSCVD---FFNWCHLVPQHGVCNHKFYGKQCCKSC 1217
K PP + CN C +K D C ++C + C+ +CC SC
Sbjct: 1517 KPRPPEFKKCNQQAC---KKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
Score = 110 bits (276), Expect = 6e-24
Identities = 74/233 (31%), Positives = 106/233 (45%), Gaps = 24/233 (10%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
SECS +CG G + C +TQ++S C+A +P K C+ C A W G WS
Sbjct: 1323 SECSTTCGLGAYWRRVEC----STQMDSD-CAAIQRP-DPAKRCHLRPC-AGWKVGNWSK 1375
Query: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQ 1002
CS+ C+GG + R+IQCV + + P +CN C W + PWSQ
Sbjct: 1376 CSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA-WQVEPWSQ 1434
Query: 1003 CSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWS 1062
CS++CG GV++R + C G C RP C C W +W
Sbjct: 1435 CSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSCNEHLC-----CHWATGNWD 1481
Query: 1063 ECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRAC 1115
CS +CG G +KR ++C +G T + +C KP + CN++AC
Sbjct: 1482 LCSTSCGGGFQKRTVQCVPS--EGNK-TEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 101 bits (251), Expect = 5e-21
Identities = 62/194 (31%), Positives = 84/194 (43%), Gaps = 28/194 (14%)
Query: 984 QACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGC 1043
Q N H W +G WS+CS TCG G R + C T +S C ++ RP+ + C
Sbjct: 1307 QLTNGHGSA-HWIVGNWSECSTTCGLGAYWRRVECS-----TQMDSDCAAIQRPDPAKRC 1360
Query: 1044 VLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPN 1103
L C W +WS+CS C G + RE++C + L F + I P
Sbjct: 1361 HLRPCAG-----WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPP- 1414
Query: 1104 LDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLH 1163
L +CN C A W PW QC+ +CGGGVQ R V C P C
Sbjct: 1415 --LSMSCNPEPCEA---------WQVEPWSQCSRSCGGGVQERGVFC-----PGGLCDWT 1458
Query: 1164 QKPPVLRACNTNFC 1177
++P +CN + C
Sbjct: 1459 KRPTSTMSCNEHLC 1472
Score = 98.2 bits (243), Expect = 4e-20
Identities = 61/191 (31%), Positives = 87/191 (45%), Gaps = 26/191 (13%)
Query: 934 YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQA-CNSHAC 991
+W G W+ CS C G + + C++K V + C P + P Q C+ AC
Sbjct: 827 FWQYGHWTECSVTCGTGIRRQTAHCIKKG----RGMVKATFCDPETQPNGRQKKCHEKAC 882
Query: 992 PPQWSLGPWSQCSKTCG-RGVRKRELLC---KGSAAETLPESQCTSLPRPELQEGCVLG- 1046
PP+W G W CS TCG G +KR +LC S + LP + C L +P+ C
Sbjct: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDI 942
Query: 1047 RCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDL 1106
CP + W +WSECS +CG GVR R + C++ + C +KPN
Sbjct: 943 LCPSD----WTVGNWSECSVSCGGGVRIRSVTCAKN---------HDEPCDVTRKPN--S 987
Query: 1107 EETCNRRACPA 1117
C + CP+
Sbjct: 988 RALCGLQQCPS 998
Score = 93.2 bits (230), Expect = 1e-18
Identities = 60/196 (30%), Positives = 89/196 (45%), Gaps = 20/196 (10%)
Query: 995 WSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPE-LQEGCVLGRCPKNSR 1053
W G W++CS TCG G+R++ C + + C +P Q+ C CP
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP--- 884
Query: 1054 LQWVASSWSECSATCGL-GVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNR 1112
+W A W CSATCG G +KR + C + + P C+++ KP L +CNR
Sbjct: 885 -RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQ-ALPPTDCQHLLKPKTLL--SCNR 940
Query: 1113 RA-CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRA 1171
CP+ W W +C+V+CGGGV+ RSV C + C + +KP
Sbjct: 941 DILCPSD--------WTVGNWSECSVSCGGGVRIRSVTCAK--NHDEPCDVTRKPNSRAL 990
Query: 1172 CNTNFCPAPEKREDPS 1187
C CP+ + P+
Sbjct: 991 CGLQQCPSSRRVLKPN 1006
Score = 38.5 bits (88), Expect = 0.040
Identities = 38/133 (28%), Positives = 53/133 (39%), Gaps = 20/133 (15%)
Query: 1043 CVLGRC------PKNSRLQWVA-SSWSECSATCGLGVRKREMKCS--EKGFQGKLITFPE 1093
C+ G+C P++ W S WS CS TCG GV+ E C+ E F GK T
Sbjct: 526 CMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGER 585
Query: 1094 RRCR--NIKKPNLDLEETCNRRACPAH---PVYNMVAGWYSL--PWQQCTVTC---GGGV 1143
+R R N+ P T + C P N + W+ + P C + C G
Sbjct: 586 KRYRLCNV-HPCRSEAPTFRQMQCSEFDTVPYKNELYHWFPIFNPAHPCELYCRPIDGQF 644
Query: 1144 QTRSVHCVQQGRP 1156
+ + V G P
Sbjct: 645 SEKMLDAVIDGTP 657
Score = 37.4 bits (85), Expect = 0.088
Identities = 38/115 (33%), Positives = 48/115 (41%), Gaps = 37/115 (32%)
Query: 523 WQFGAKAKL---CSLGF-VKDI-CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQC 577
W+ G +K CS GF +++I C HR +F+ G LSM C C
Sbjct: 1368 WKVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLA---GIPPPLSMSCNPEPC 1424
Query: 578 VKFGELGPRPIHGQWSAWS--KWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPG 630
AW WS+CSR+CGGGV QER G+FCPG
Sbjct: 1425 ---------------EAWQVEPWSQCSRSCGGGV--QER----------GVFCPG 1452
Score = 35.4 bits (80), Expect = 0.33
Identities = 28/100 (28%), Positives = 35/100 (35%), Gaps = 22/100 (22%)
Query: 564 TVCGLSMWCRQ--------GQCVKFGELGP------RPIHGQWSAWSKWSECSRTCGGGV 609
T CGL + R+ C P RP G W WS+CSR C GG
Sbjct: 1327 TTCGLGAYWRRVECSTQMDSDCAAIQRPDPAKRCHLRPCAG-WKV-GNWSKCSRNCSGGF 1384
Query: 610 KFQERHC------NNPKPQYGGLFCPGSSRIYQLCNINPC 643
K +E C N +P + + CN PC
Sbjct: 1385 KIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPC 1424
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 645 bits (1663), Expect = 0.0
Identities = 377/1055 (35%), Positives = 540/1055 (51%), Gaps = 84/1055 (7%)
Query: 15 GSGPPRGLAGLGRVAKALQLCCLCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGS 74
G PR A L R L L C ++ G + L+ V PV VD+ GS
Sbjct: 3 GGPSPRSPAPLLR--PLLLLLCALAPGAPGPAPGRATEGRAALD----IVHPVRVDAGGS 56
Query: 75 YISHDILHNGRKKRSAQNARSS-LHYRFSAFGQELHLELKPSA-ILSSHFIVQVLGKDGA 132
++S+++ +KR R + Y G+EL L + +L+ F+ + + G
Sbjct: 57 FLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLLAPGFVSETRRRGGL 116
Query: 133 SETQ-KPEVQQCFYQGFIRNDSSSS--VAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEH 189
+ C G +++ A+S C GL G+ + ++ I PL A+
Sbjct: 117 GRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLSNEDYFIEPLDSAPAR-- 174
Query: 190 NYSSPAGHHPHVLYKRTAEEKI-QRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRL 248
P PHV+YKR A E++ QR S Y + ++ RL
Sbjct: 175 ----PGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPELESRRERWEQRQQWRRPRL 230
Query: 249 QKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEK 308
++ H +RS K + VETLVVAD KMVE
Sbjct: 231 RRLH------------------------------QRSVSKEKW---VETLVVADAKMVEY 257
Query: 309 HGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSF 368
HG+ V +Y+LT+MNMV+GLF D +IG+ I++ +V L+LLE E L I HHAD +L SF
Sbjct: 258 HGQPQVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSF 317
Query: 369 CQWQSALIGKNGKR---HDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINED 425
C+WQ ++ K HD AILLT D+C+ N PC+TLG + ++GMC +RSC+INED
Sbjct: 318 CKWQKSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINED 377
Query: 426 TGLGLAFTIAHESGHNFGMIHDGEGNPCRKAEGN--IMSPTLTGNNGVFSWSSCSRQYLK 483
TGL LAFT+AHE GH+FG+ HDG GN C IMSP L + +WS CSRQY+
Sbjct: 378 TGLPLAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYIT 437
Query: 484 KFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKS 543
+FL CL D+P +P PG +YD QC+ Q+GA + C + ++C +
Sbjct: 438 RFLDRGWGLCL-DDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCE--DMDNVCHT 494
Query: 544 LWCHRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSR 603
LWC VG C +K A +GT CG + WC G+CV G P + G WS WS WS CSR
Sbjct: 495 LWC-SVGTTCHSKLDAAVDGTRCGENKWCLSGECVPVG-FRPEAVDGGWSGWSAWSICSR 552
Query: 604 TCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPF 663
+CG GV+ ER C P P+Y G +C G + ++LCN+ C FR QC+ +++ +
Sbjct: 553 SCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLY 612
Query: 664 RGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNK--NDVCIDGVCE 721
+G + W P V + + C+L+C+ N F + V DGTPC + D+CI+G+C+
Sbjct: 613 KGQLHTWVPV--VNDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICK 670
Query: 722 LVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQE 781
VGCD E+ S A+ D CGVC G+ STC G + + + Y V LIPAGAR I IQE
Sbjct: 671 NVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTF-EEAEGLGYVDVGLIPAGAREIRIQE 729
Query: 782 LQVSSSYLAVRSLS-QKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNET 840
+ ++++LA+RS +KY+L GGW+I W G++ AGTTF Y R N E L +PGPT E
Sbjct: 730 VAEAANFLALRSEDPEKYFLNGGWTIQWNGDYQVAGTTFTYARRGNW-ENLTSPGPTKEP 788
Query: 841 LVFEILMQGKNPGIAWKYALPKVMNG---TPPATKRPAYTWSI-VQSECSVSCGGGYINV 896
+ ++L Q NPG+ ++Y + + G PP P ++W ++C+V+CG G
Sbjct: 789 VWIQLLFQESNPGVHYEYTIHREAGGHDEVPP----PVFSWHYGPWTKCTVTCGRGVQRQ 844
Query: 897 KAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACA-GGQQSRK 955
CL Q V+ C +P + + C+ CPA W GEW CS +C GG R
Sbjct: 845 NVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRA 904
Query: 956 IQCVQKKPFQKEEAVLHSLCP-VSTPTQVQACNSHA-CPPQWSLGPWSQCSKTCGRGVRK 1013
+ C++ ++ A+ C + P CN H CP W++G WSQCS TCG G ++
Sbjct: 905 VLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQR 964
Query: 1014 RELLCKGSAAETLPESQCTSLPRPELQEGCVLGRC 1048
R +LC E+Q +P + C L C
Sbjct: 965 RNVLCTNDTGVPCDEAQ-----QPASEVTCSLPLC 994
Score = 129 bits (323), Expect = 2e-29
Identities = 93/296 (31%), Positives = 114/296 (38%), Gaps = 49/296 (16%)
Query: 933 AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
A W G WS CS C G R ++C + P P + C+ C
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSGRD--------EDCAPAGRPQPARRCHLRPCA 1464
Query: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSA-AETLPESQCTSLP-RPELQEGCVLGRCPK 1050
W G WS+CS++CG G R++ C + L C P +P C C
Sbjct: 1465 T-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC-- 1521
Query: 1051 NSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
L W SSW ECS CG G ++R + C E G C +PN
Sbjct: 1522 ---LSWYTSSWRECSEACGGGEQQRLVTCPEPGL-----------CEEALRPN------- 1560
Query: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV--QQGRP---SSSCLLHQK 1165
R C HP V G PW QC+ CGGGVQ R V CV Q G P S C
Sbjct: 1561 TTRPCNTHPCTQWVVG----PWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAW 1616
Query: 1166 PPVLRACNTNFCPAPEKREDPSCVD---FFNWCHLVPQHGVCNHKFYGKQCCKSCT 1218
P R C T C E E P C F +C + G C QCC+SC+
Sbjct: 1617 PESSRPCGTEDC---EPVEPPRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCS 1669
Score = 98.6 bits (244), Expect = 3e-20
Identities = 70/223 (31%), Positives = 96/223 (43%), Gaps = 30/223 (13%)
Query: 992 PP--QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG-CVLGRC 1048
PP W GPW++C+ TCGRGV+++ + C A + E C L RP+ Q+ C C
Sbjct: 820 PPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPC 879
Query: 1049 PKNSRLQWVASSWSECSATCGLG-VRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLE 1107
P +W A W CS++CG G + +R + C + C ++ +P E
Sbjct: 880 PA----RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRP--PTE 933
Query: 1108 ETCNRRA-CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ-GRPSSSCLLHQK 1165
CNR CPA W W QC+VTCG G Q R+V C G P C Q+
Sbjct: 934 TPCNRHVPCPAT--------WAVGNWSQCSVTCGEGTQRRNVLCTNDTGVP---CDEAQQ 982
Query: 1166 PPVLRACNTNFCPAPEKREDP-------SCVDFFNWCHLVPQH 1201
P C+ C P P S + FN +P H
Sbjct: 983 PASEVTCSLPLCRWPLGTLGPEGSGSGSSSHELFNEADFIPHH 1025
Score = 93.6 bits (231), Expect = 1e-18
Identities = 61/200 (30%), Positives = 87/200 (43%), Gaps = 27/200 (13%)
Query: 883 SECSVSCGGGYI--NVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEW 940
SECS +CG G + V+ RD++ C+ +P + C+ C A W G W
Sbjct: 1421 SECSTTCGLGAVWRPVRCSSGRDED-------CAPAGRPQPARR-CHLRPC-ATWHSGNW 1471
Query: 941 STCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPW 1000
S CS++C GG R +QCV + + H + P + C + C W W
Sbjct: 1472 SKCSRSCGGGSSVRDVQCVDTRDLRPLRP-FHCQPGPAKPPAHRPCGAQPC-LSWYTSSW 1529
Query: 1001 SQCSKTCGRGVRKRELLCKGSAAETLPE-SQCTSLPRPELQEGCVLGRCPKNSRLQWVAS 1059
+CS+ CG G ++R + C PE C RP C C QWV
Sbjct: 1530 RECSEACGGGEQQRLVTC--------PEPGLCEEALRPNTTRPCNTHPC-----TQWVVG 1576
Query: 1060 SWSECSATCGLGVRKREMKC 1079
W +CS CG GV++R +KC
Sbjct: 1577 PWGQCSGPCGGGVQRRLVKC 1596
Score = 87.8 bits (216), Expect = 6e-17
Identities = 47/153 (30%), Positives = 71/153 (46%), Gaps = 14/153 (9%)
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPT-QVQACNSHACPP 993
W G W+ C+ C G Q + + C++++ +E P+ P Q + C+ CP
Sbjct: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDE---EHCDPLGRPDDQQRKCSEQPCPA 881
Query: 994 QWSLGPWSQCSKTCGRG-VRKRELLCKGSAA----ETLPESQCTSLPRPELQEGCVLG-R 1047
+W G W CS +CG G + +R +LC S L C LPRP + C
Sbjct: 882 RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVP 941
Query: 1048 CPKNSRLQWVASSWSECSATCGLGVRKREMKCS 1080
CP W +WS+CS TCG G ++R + C+
Sbjct: 942 CPAT----WAVGNWSQCSVTCGEGTQRRNVLCT 970
Score = 47.4 bits (111), Expect = 9e-05
Identities = 30/82 (36%), Positives = 41/82 (50%), Gaps = 4/82 (4%)
Query: 1102 PNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGRP--SS 1158
P + E T +R A V V W+ PW +CTVTCG GVQ ++V+C++ Q P
Sbjct: 800 PGVHYEYTIHREAGGHDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEE 859
Query: 1159 SC-LLHQKPPVLRACNTNFCPA 1179
C L + R C+ CPA
Sbjct: 860 HCDPLGRPDDQQRKCSEQPCPA 881
Score = 40.8 bits (94), Expect = 0.008
Identities = 22/62 (35%), Positives = 28/62 (45%), Gaps = 2/62 (3%)
Query: 1116 PAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTN 1175
PA P+ AGW + W +C+ TCG G R V C GR C +P R C+
Sbjct: 1404 PADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRC-SSGR-DEDCAPAGRPQPARRCHLR 1461
Query: 1176 FC 1177
C
Sbjct: 1462 PC 1463
Score = 38.9 bits (89), Expect = 0.030
Identities = 20/61 (32%), Positives = 32/61 (52%), Gaps = 13/61 (21%)
Query: 1059 SSWSECSATCGLGVRKREMKCSE--KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACP 1116
S+WS CS +CG+GV+ E +C++ ++G+ +R R CN +ACP
Sbjct: 545 SAWSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFR-----------LCNLQACP 593
Query: 1117 A 1117
A
Sbjct: 594 A 594
Score = 36.6 bits (83), Expect = 0.15
Identities = 34/101 (33%), Positives = 42/101 (41%), Gaps = 27/101 (26%)
Query: 566 CGLSMWCRQGQCVKFGELGP-RPIHGQWS----------------AW--SKWSECSRTCG 606
CG R QCV +L P RP H Q +W S W ECS CG
Sbjct: 1478 CGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACG 1537
Query: 607 GGVKFQERHCNNPKPQYGGLFCPGSSR--IYQLCNINPCNE 645
GG Q+R P+P GL C + R + CN +PC +
Sbjct: 1538 GGE--QQRLVTCPEP---GL-CEEALRPNTTRPCNTHPCTQ 1572
Score = 33.5 bits (75), Expect = 1.3
Identities = 29/98 (29%), Positives = 43/98 (43%), Gaps = 19/98 (19%)
Query: 564 TVCGL-SMW----CRQGQ---CVKFGELGP-RPIH----GQWSAWSKWSECSRTCGGGVK 610
T CGL ++W C G+ C G P R H W + WS+CSR+CGGG
Sbjct: 1425 TTCGLGAVWRPVRCSSGRDEDCAPAGRPQPARRCHLRPCATWHS-GNWSKCSRSCGGGSS 1483
Query: 611 FQERHC---NNPKPQYGGLFCPGSSR--IYQLCNINPC 643
++ C + +P PG ++ ++ C PC
Sbjct: 1484 VRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
Score = 32.0 bits (71), Expect = 3.7
Identities = 17/55 (30%), Positives = 23/55 (41%), Gaps = 2/55 (3%)
Query: 1125 AGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCPA 1179
+GW + W C+ +CG GVQ+ C Q + R CN CPA
Sbjct: 542 SGWSA--WSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPA 594
Score = 32.0 bits (71), Expect = 3.7
Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 592 WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPC 643
W A WSECS TCG G ++ C++ + + G + + C++ PC
Sbjct: 1415 WQA-GNWSECSTTCGLGAVWRPVRCSSGRDE--DCAPAGRPQPARRCHLRPC 1463
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 596 bits (1537), Expect = e-170
Identities = 387/1201 (32%), Positives = 591/1201 (49%), Gaps = 127/1201 (10%)
Query: 60 DYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNAR---------------SSLHYRFSAF 104
+Y V+P+ V++ G ++ H R +RS +A S HYR SAF
Sbjct: 47 EYEIVSPIRVNALGEPFPTNV-HFKRTRRSINSATDPWPAFASSSSSSTSSQAHYRLSAF 105
Query: 105 GQELHLELKPSA-ILSSHFIVQVLGKDGASET-----QKPEVQQCFYQGFIRNDSSSSVA 158
GQ+ L +A ++ F V +LG G ++T ++ E++ CFY+G++ +S +
Sbjct: 106 GQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEHTAV 165
Query: 159 VSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYP 218
+S C+G+ G R+ ++ I PL + QE + PH++Y+R+A ++ P
Sbjct: 166 ISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQ---NKPHIIYRRSAPQR------EP 216
Query: 219 GSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGS 278
+GR+ S H+ ++T R +K G R A ++ L + + +
Sbjct: 217 STGRHACDTSEHKNRHSKDKKKT-----RARKW---GERINLAGDVAALNSGLATEAFSA 268
Query: 279 SG------RPRRSAGKSQKGLN----VETLVVADKKMVEKHGKGNVTTYILTVMNMVSGL 328
G R +R+ ++++ L+ VE LVVAD +MV HG+ N+ YILT+M++V+ +
Sbjct: 269 YGNKTDNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGE-NLQHYILTLMSIVASI 327
Query: 329 FKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAIL 388
+KD +IG+ IN+V+V+LI++ E G I+ +A +L +FCQWQ + G HD A+L
Sbjct: 328 YKDPSIGNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIHHDTAVL 387
Query: 389 LTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 448
LT DIC ++ CDTLG A + +C YRSC+I+ED+GL AFTIAHE GH F M HD
Sbjct: 388 LTRQDICR-AHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHD- 445
Query: 449 EGNPCR----KAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQY 504
+ N C+ K+ ++M+PTL + WS CSR+Y+ +FL T CL++EP ++ Y
Sbjct: 446 DNNKCKEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEP-ESRPY 504
Query: 505 KYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVG--HR-CETKFMPAA 561
P +LPG +Y+ + QC+ FG +++C C+ LWC+ V H+ C T+ P A
Sbjct: 505 PLPVQLPGILYNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWA 561
Query: 562 EGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKP 621
+GT C C+ G CV E+ G W +WS + CSRTCGGG+K R CN P+P
Sbjct: 562 DGTECEPGKHCKYGFCVP-KEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEP 620
Query: 622 QYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFR--GWF--YQWKP-YTKV 676
+ GG +C G ++ CN PC + DFR +QCA ++ K F G +W P Y+ +
Sbjct: 621 KNGGKYCVGRRMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGI 680
Query: 677 EEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSD 736
+DRCKL+C+ ++ + +V DGTPC + ND+C+ G+C GCDH L SKA D
Sbjct: 681 LMKDRCKLFCRVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRD 740
Query: 737 ACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVS-----SSYLAV 791
CGVC GDNS+CK G + H Y VV IPAGA +I++++ S +YLA+
Sbjct: 741 KCGVCGGDNSSCKTVAGTFNTVHYG--YNTVVRIPAGATNIDVRQHSFSGETDDDNYLAL 798
Query: 792 RSLSQKYYLTGGWSIDW-PGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGK 850
S ++ L G + + E EY S ER+ + + L+ ++L GK
Sbjct: 799 SSSKGEFLLNGNFVVTMAKREIRIGNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGK 858
Query: 851 --NPGIAWKYALPKVMNGTPPATKRPAYTWSI--VQSECSVSCGGGYINVKAICLRDQN- 905
NP + + + + P K + W+ CS C G K +C R+ +
Sbjct: 859 LYNPDVRYSFNI-------PIEDKPQQFYWNSHGPWQACSKPCQGER-KRKLVCTRESDQ 910
Query: 906 TQVNSSFCSAKTKP--VTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKP 963
V+ C +P +TEP C C W S CS C G ++ I C +
Sbjct: 911 LTVSDQRCDRLPQPGHITEP--CGT-DCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSR 967
Query: 964 FQ-KEEAVLHSLCPV-STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGS 1021
K E V C P+ + C+ W W++CSK+C G ++R +C +
Sbjct: 968 LDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNT 1027
Query: 1022 AAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSE 1081
+ L +S+CT QE + RC + QW + WSEC TCG G + R++ C
Sbjct: 1028 RNDVLDDSKCTH------QEKVTIQRCSEFPCPQWKSGDWSECLVTCGKGHKHRQVWC-- 1079
Query: 1082 KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGG 1141
Q +R C KP +TC + C A W + PW QC+VTCG
Sbjct: 1080 ---QFGEDRLNDRMCDPETKPT--SMQTCQQPEC---------ASWQAGPWGQCSVTCGQ 1125
Query: 1142 GVQTRSVHCV----QQGRPSSSCLLHQKPPVLRACNTNFC----PAPEKREDPSCVDFFN 1193
G Q R+V C+ + C +P + C C APE R
Sbjct: 1126 GYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPPPAAPETRRSTYSAPRTQ 1185
Query: 1194 W 1194
W
Sbjct: 1186 W 1186
Score = 150 bits (380), Expect = 5e-36
Identities = 105/340 (30%), Positives = 143/340 (42%), Gaps = 61/340 (17%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
SEC V+CG G+ + + C ++ ++N C +TKP T + C C A W G W
Sbjct: 1062 SECLVTCGKGHKHRQVWCQFGED-RLNDRMCDPETKP-TSMQTCQQPEC-ASWQAGPWGQ 1118
Query: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST-PTQVQACNSHACPP-------- 993
CS C G Q R ++C+ V + C +T PT Q C +C P
Sbjct: 1119 CSVTCGQGYQLRAVKCIIGTYMS---VVDDNDCNAATRPTDTQDCELPSCHPPPAAPETR 1175
Query: 994 ---------QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCV 1044
QW G W+ CS TCG+G R R + C+ ES C +LPRP +E C
Sbjct: 1176 RSTYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPRPVAKEECS 1235
Query: 1045 LGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNL 1104
+ C QW A WS CS TCG G R++ C + +I E C P
Sbjct: 1236 VTPCG-----QWKALDWSSCSVTCGQGRATRQVMC--VNYSDHVIDRSE--CDQDYIPET 1286
Query: 1105 DLEETCNRRACP---------AHPVYN--------------MVAG--WYSLPWQQCTVTC 1139
D + C+ CP HP N ++ G W + PW C+ TC
Sbjct: 1287 D--QDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTC 1344
Query: 1140 GGGVQTRSVHCV-QQGRPSSSCLLHQKPPVLRACNTNFCP 1178
GG Q R V C + G ++ C+ KP RAC + CP
Sbjct: 1345 AGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP 1384
Score = 150 bits (378), Expect = 9e-36
Identities = 95/306 (31%), Positives = 133/306 (43%), Gaps = 26/306 (8%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
S CSVSCG G+ C+ + + S +C KP K C CP W G WS
Sbjct: 1451 SSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRK-CRGGRCPK-WKAGAWSQ 1508
Query: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQACNSHACP-PQWSLGPW 1000
CS +C G Q R + C + + C P + P + C CP W W
Sbjct: 1509 CSVSCGRGVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEW 1564
Query: 1001 SQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASS 1060
+C+KTCG G R R+++C + ++C RP +E C L C W+
Sbjct: 1565 QECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC----EYVWITGE 1620
Query: 1061 WSECSATCGLGVRKREMKCSE--KGFQGKLITFPER-RCRNIKKPNLDLEETCNRRACPA 1117
WSECS TCG G ++R + CSE G + ++ C + P++ C R CP
Sbjct: 1621 WSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSV---HPCYLRDCP- 1676
Query: 1118 HPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV-QQGRPSSSCLLHQKPPVLRAC-NTN 1175
+ A W W C+V+CG GV RSV C+ + +PS C KP + C N
Sbjct: 1677 -----VSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVY 1731
Query: 1176 FCPAPE 1181
C P+
Sbjct: 1732 NCELPQ 1737
Score = 148 bits (373), Expect = 4e-35
Identities = 92/306 (30%), Positives = 132/306 (43%), Gaps = 33/306 (10%)
Query: 884 ECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP--AYWMPGEWS 941
EC+ CGGG +C R + C KP + CN +CP A W G WS
Sbjct: 1393 ECTKLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQ-CNTHACPHDAAWSTGPWS 1451
Query: 942 TCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWS 1001
+CS +C G + R + C+ K E L + P + C CP +W G WS
Sbjct: 1452 SCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHL---AKPHGHRKCRGGRCP-KWKAGAWS 1507
Query: 1002 QCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSW 1061
QCS +CGRGV++R + C+ + E++C RPE + C RCP + W A W
Sbjct: 1508 QCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLYT---WRAEEW 1564
Query: 1062 SECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVY 1121
EC+ TCG G R R++ C + RC K+P +R +C P
Sbjct: 1565 QECTKTCGEGSRYRKVVCVDDNKN----EVHGARCDVSKRP-------VDRESCSLQPCE 1613
Query: 1122 NMVAGWYSLPWQQCTVTCGGGVQTRSVHC--VQQGRPSSSCLLH-------QKPPVLRAC 1172
+ W + W +C+VTCG G + R V C + G+ + +PP + C
Sbjct: 1614 YV---WITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPC 1670
Query: 1173 NTNFCP 1178
CP
Sbjct: 1671 YLRDCP 1676
Score = 147 bits (370), Expect = 8e-35
Identities = 94/342 (27%), Positives = 137/342 (40%), Gaps = 61/342 (17%)
Query: 874 PAYTWSIVQ-SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP 932
P W + S CSV+CG G + +C+ + ++ S C P T+ C+ CP
Sbjct: 1238 PCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQD-CSMSPCP 1296
Query: 933 A---------------------------------YWMPGEWSTCSKACAGGQQSRKIQCV 959
W G W CS CAGG Q R + C
Sbjct: 1297 QRTPDSGLAQHPFQNEDYRPRSASPSRTHVLGGNQWRTGPWGACSSTCAGGSQRRVVVCQ 1356
Query: 960 QKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCK 1019
+ + + V P + +AC S CP QW+ G W +C+K CG G+R R ++C+
Sbjct: 1357 DENGYTANDCVERI-----KPDEQRACESGPCP-QWAYGNWGECTKLCGGGIRTRLVVCQ 1410
Query: 1020 GSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKC 1079
S E P+ C L +P +E C CP ++ W WS CS +CG G ++R + C
Sbjct: 1411 RSNGERFPDLSCEILDKPPDREQCNTHACPHDA--AWSTGPWSSCSVSCGRGHKQRNVYC 1468
Query: 1080 SEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTC 1139
K C+++ KP+ C CP W + W QC+V+C
Sbjct: 1469 MAKDGS----HLESDYCKHLAKPH--GHRKCRGGRCPK---------WKAGAWSQCSVSC 1513
Query: 1140 GGGVQTRSVHC---VQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
G GVQ R V C + + C + +P R C CP
Sbjct: 1514 GRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Score = 116 bits (291), Expect = 1e-25
Identities = 76/242 (31%), Positives = 111/242 (45%), Gaps = 23/242 (9%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAY-WMPGEWS 941
S+CSVSCG G C + + C+ T+P +E + C CP Y W EW
Sbjct: 1507 SQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESE-RDCQGPRCPLYTWRAEEWQ 1565
Query: 942 TCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST-PTQVQACNSHACPPQWSLGPW 1000
C+K C G + RK+ CV + V + C VS P ++C+ C W G W
Sbjct: 1566 ECTKTCGEGSRYRKVVCVD----DNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEW 1621
Query: 1001 SQCSKTCGRGVRKRELLCKG--SAAETLPESQCTSLPRPELQ----EGCVLGRCPKNSRL 1054
S+CS TCG+G ++R + C + E S T++ P Q C L CP ++
Sbjct: 1622 SECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYLRDCPVSAT- 1680
Query: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITF----PERR--CRNIKKPNLDLEE 1108
W +W CS +CG+GV +R ++C Q + PE R CRN+ N +L +
Sbjct: 1681 -WRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVY--NCELPQ 1737
Query: 1109 TC 1110
C
Sbjct: 1738 NC 1739
Score = 49.7 bits (117), Expect = 2e-05
Identities = 30/94 (31%), Positives = 38/94 (40%), Gaps = 12/94 (12%)
Query: 876 YTWSIVQ-SECSVSCGGGYINVKAICLRDQNTQVNSSF-------CSAKTKPVTEPKICN 927
Y W + SECSV+CG GY C + N + C P P C
Sbjct: 1614 YVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHP--CY 1671
Query: 928 AFSCP--AYWMPGEWSTCSKACAGGQQSRKIQCV 959
CP A W G W +CS +C G R +QC+
Sbjct: 1672 LRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCL 1705
Score = 37.4 bits (85), Expect = 0.088
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 4/63 (6%)
Query: 584 GPRPIHGQWSAWSKWSECSRTCGGGVKFQERHC-NNPKPQYGGLFCPGSSRIY--QLCNI 640
GPR W A +W EC++TCG G ++++ C ++ K + G C S R + C++
Sbjct: 1551 GPRCPLYTWRA-EEWQECTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSL 1609
Query: 641 NPC 643
PC
Sbjct: 1610 QPC 1612
Score = 33.5 bits (75), Expect = 1.3
Identities = 14/29 (48%), Positives = 19/29 (65%), Gaps = 4/29 (13%)
Query: 582 ELGPRPIHGQWSAWSKWSECSRTCGGGVK 610
E GP P QW A+ W EC++ CGGG++
Sbjct: 1379 ESGPCP---QW-AYGNWGECTKLCGGGIR 1403
Score = 31.2 bits (69), Expect = 6.3
Identities = 34/124 (27%), Positives = 50/124 (40%), Gaps = 35/124 (28%)
Query: 572 CRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCP-G 630
CR G+C K W A + WS+CS +CG GV Q+RH C G
Sbjct: 1493 CRGGRCPK------------WKAGA-WSQCSVSCGRGV--QQRHVG----------CQIG 1527
Query: 631 SSRIYQLCNINPCN--ENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKV--EEEDRCKLYC 686
+ +I + NP E+ D + +C Y + +W+ TK E K+ C
Sbjct: 1528 THKIARETECNPYTRPESERDCQGPRCPLYTWRA-----EEWQECTKTCGEGSRYRKVVC 1582
Query: 687 KAEN 690
+N
Sbjct: 1583 VDDN 1586
Score = 30.8 bits (68), Expect = 8.2
Identities = 20/66 (30%), Positives = 31/66 (46%), Gaps = 10/66 (15%)
Query: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNN------PKPQYGGLFCPGSSRIYQLCNINPC 643
GQW A WS CS TCG G ++ C N + + + P + Q C+++PC
Sbjct: 1240 GQWKALD-WSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETD---QDCSMSPC 1295
Query: 644 NENSLD 649
+ + D
Sbjct: 1296 PQRTPD 1301
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 552 bits (1422), Expect = e-157
Identities = 364/1197 (30%), Positives = 568/1197 (47%), Gaps = 164/1197 (13%)
Query: 61 YVFVTPVEVDSAGSYI--SHDILHNGRKKRSAQNARSS---LHYRFSAFGQELHLELKPS 115
Y V P V+ G SH H R+KRS++ HYRF+A+GQ L L
Sbjct: 40 YEVVIPERVNEFGEVFPQSH---HFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTAD 96
Query: 116 A-ILSSHFIVQVLG--KDGA--SETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIR 170
A L++ + LG + GA S+ +++ CFY+G + + VS C GL+G +
Sbjct: 97 ASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFK 156
Query: 171 TRKNEFLISPLPQLLAQEHNYSSPAGHH-PHVLYKRTAEEKIQRYRGYPGSGRNYPGYSP 229
+ E+ + P+ + E+ GH+ PH++Y++ + Y +
Sbjct: 157 GQNGEYFLEPIMKADGNEYE----DGHNKPHLIYRQDLNNSFLQTLKYCSVSESQ--IKE 210
Query: 230 SHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKS 289
+ +P + S E + K+ G K P DE S + R +
Sbjct: 211 TSLPFHTYSNMNE--DLNVMKERVLGHTSKNVPLK---------DERRHSRKKRLISYPR 259
Query: 290 QKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLE 349
+E +V AD K+V HG N+ YILT+M++V+ ++KD +IG+ I++VVV L+++
Sbjct: 260 Y----IEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIH 314
Query: 350 QEPGGLLINHHADQSLNSFCQWQSA---LIGKNGKRHDHAILLTGFDICSWKNEPCDTLG 406
+E G +IN +L +FC WQ L + HD A+L+T DICS K E C+ LG
Sbjct: 315 REEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSK-EKCNMLG 373
Query: 407 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNP-CRK---AEGNIMS 462
+ + +C +SC INE+ GL AFTIAHE GH G+ HD NP C++ + ++M+
Sbjct: 374 LSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDD--NPRCKEMKVTKYHVMA 431
Query: 463 PTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCK 522
P L+ + +SWS+CSR+Y+ +FL T CL+D+P + Y P +LPG YD + QC+
Sbjct: 432 PALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEE-IYNLPSELPGSRYDGNKQCE 490
Query: 523 WQFGAKAKLCSLGFVKDICKSLWC---HRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVK 579
FG +++C +IC LWC ++ C T+ +P A+GT CG M CR G CV
Sbjct: 491 LAFGPGSQMCPH---INICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVN 547
Query: 580 FGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCN 639
E RP++G+W W +S CSRTCGGG++ R CN P+P+ GG +C G ++ CN
Sbjct: 548 -KETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCN 606
Query: 640 INPCNENSLDFRAQQCAEYNSKPFR----GWFYQWKP-YTKVEEEDRCKLYCKAENFEFF 694
+ C + + DFR +QC+++N K +W P Y+ + +DRCKLYC+ +F
Sbjct: 607 TDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYF 666
Query: 695 FAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGL 754
+ + V+DGTPC +D+C+ G C GCDH L S A D CGVC GDNS+CK G+
Sbjct: 667 YLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGV 726
Query: 755 YLNQHKANEYYPVVLIPAGARSIEIQEL----QVSSSYLAVRSLSQKYYLTGGWSIDW-P 809
+ + H Y VV IPAGA +++I++ Q SYLA+ + G + +
Sbjct: 727 FNSSHYG--YNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSK 784
Query: 810 GEFPFAG--TTFEYQRSFNRPERLYAPGPTNETLVFEILMQGK--NPGIAWKYALP---- 861
E G T EY S N ER+ + + L+ ++L G NP + + + +P
Sbjct: 785 KEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEER 844
Query: 862 ----------------KVMNGTPPAT--------------------KRPAYTWSIVQSEC 885
K+ G P++ ++C
Sbjct: 845 SDMFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDC 904
Query: 886 ------------SVSCGGGYINVKAICLR-----DQNTQVNSSFCSAKTKPVTEPKICNA 928
S CG GY + C++ Q QV+ +C + KP T+ ++C+
Sbjct: 905 ELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQ-ELCHG 963
Query: 929 FSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNS 988
W EWS CS++C GG++SR+ C+ + + L V+ + CN
Sbjct: 964 NCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTR----ENCNE 1019
Query: 989 HACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRC 1048
+C P W+ WS+C TCG+G ++R++ C+ + + L + C S +PE C L C
Sbjct: 1020 FSC-PSWAASEWSECLVTCGKGTKQRQVWCQLN-VDHLSDGFCNSSTKPESLSPCELHTC 1077
Query: 1049 PKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEE 1108
W W C+ TCG G + R++KC + L + C +P+
Sbjct: 1078 -----ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVL---EDTECHEASRPS----- 1124
Query: 1109 TCNRRACPAHP---------------VYNMVAGWYSLPWQQCTVTCGGGVQTRSVHC 1150
+R++C P + +A W W C+V+CG G Q R V C
Sbjct: 1125 --DRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC 1179
Score = 149 bits (376), Expect = 2e-35
Identities = 88/314 (28%), Positives = 140/314 (44%), Gaps = 68/314 (21%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPA--------- 933
S CS SCG G + +C+ + + ++ ++C + +P+ E + C+ +CP
Sbjct: 1217 SPCSASCGHGKTTRQVLCM-NYHQPIDENYCDPEVRPLMEQE-CSLAACPPAHSHFPSSP 1274
Query: 934 --------------------------------YWMPGEWSTCSKACAGGQQSRKIQCVQK 961
W G W +CS +C+GG Q R + C
Sbjct: 1275 VQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVC--- 1331
Query: 962 KPFQKEEAVLHSLCPV-STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG 1020
Q E S C S P ++Q C CP QW+ G W +CS+TCG G++ R ++C+
Sbjct: 1332 ---QDENGQSASYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGGGIKSRLVICQF 1387
Query: 1021 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS 1080
+ L + C + +P C + CP + + W W+ CSA+CG G + RE+ C
Sbjct: 1388 PNGQILEDHNCEIVNKPPSVIQCHMHACPAD--VSWHQEPWTSCSASCGKGRKYREVFCI 1445
Query: 1081 EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG 1140
++ FQ KL + C ++KP + C CP+ W + W +C+VTCG
Sbjct: 1446 DQ-FQRKL---EDTNCSQVQKP--PTHKACRSVRCPS---------WKANSWNECSVTCG 1490
Query: 1141 GGVQTRSVHCVQQG 1154
GVQ R V+C +G
Sbjct: 1491 SGVQQRDVYCRLKG 1504
Score = 145 bits (367), Expect = 2e-34
Identities = 95/341 (27%), Positives = 146/341 (42%), Gaps = 74/341 (21%)
Query: 885 CSVSCGGGYINVKAICLRDQNTQV-NSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTC 943
CSVSCG G + + RD ++ + S+C+ +P +I + F+ W G+WS C
Sbjct: 1164 CSVSCGRG-TQARYVSCRDALDRIADESYCAHLPRPA---EIWDCFTPCGEWQAGDWSPC 1219
Query: 944 SKACAGGQQSRKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQACNSHACPP--------- 993
S +C G+ +R++ C+ + + + C P P Q C+ ACPP
Sbjct: 1220 SASCGHGKTTRQVLCMNY-----HQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSP 1274
Query: 994 --------------------------------QWSLGPWSQCSKTCGRGVRKRELLCKGS 1021
QW GPW CS +C G++ R ++C+
Sbjct: 1275 VQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDE 1334
Query: 1022 AAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSE 1081
++ S P PELQ+ C G CP QW +W ECS TCG G++ R + C
Sbjct: 1335 NGQSASYCDAASKP-PELQQ-CGPGPCP-----QWNYGNWGECSQTCGGGIKSRLVICQF 1387
Query: 1082 KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGG 1141
Q + C + KP ++ C+ ACPA W+ PW C+ +CG
Sbjct: 1388 PNGQ----ILEDHNCEIVNKPPSVIQ--CHMHACPAD------VSWHQEPWTSCSASCGK 1435
Query: 1142 GVQTRSVHCVQQGR---PSSSCLLHQKPPVLRACNTNFCPA 1179
G + R V C+ Q + ++C QKPP +AC + CP+
Sbjct: 1436 GRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPS 1476
Score = 129 bits (325), Expect = 1e-29
Identities = 100/349 (28%), Positives = 141/349 (40%), Gaps = 72/349 (20%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
SEC V+CG G + C + + ++ FC++ TKP + C +C A W G W
Sbjct: 1031 SECLVTCGKGTKQRQVWCQLNVD-HLSDGFCNSSTKPESLSP-CELHTC-ASWQVGPWGP 1087
Query: 943 CSKACAGGQQSRKIQCVQKKPFQK-EEAVLHSLCPVSTPTQVQACNSHACP--------- 992
C+ C G Q R ++CV + E+ H S P+ Q+C C
Sbjct: 1088 CTTTCGHGYQMRDVKCVNELASAVLEDTECHE---ASRPSDRQSCVLTPCSFISKLETAL 1144
Query: 993 ---------PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGC 1043
QW G W+ CS +CGRG + R + C+ + ES C LPRP C
Sbjct: 1145 LPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC 1204
Query: 1044 VLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPN 1103
C +W A WS CSA+CG G R++ C E C +P
Sbjct: 1205 -FTPCG-----EWQAGDWSPCSASCGHGKTTRQVLC-----MNYHQPIDENYCDPEVRPL 1253
Query: 1104 LDLEETCNRRAC-PAHP------------------------------VYNMVAG--WYSL 1130
+E+ C+ AC PAH V+ V G W +
Sbjct: 1254 --MEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTG 1311
Query: 1131 PWQQCTVTCGGGVQTRSVHCV-QQGRPSSSCLLHQKPPVLRACNTNFCP 1178
PW C+ +C GG+Q R+V C + G+ +S C KPP L+ C CP
Sbjct: 1312 PWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCP 1360
Score = 123 bits (309), Expect = 9e-28
Identities = 89/349 (25%), Positives = 137/349 (39%), Gaps = 63/349 (18%)
Query: 884 ECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPA--YWMPGEWS 941
ECS +CGGG + IC + C KP + + C+ +CPA W W+
Sbjct: 1369 ECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ-CHMHACPADVSWHQEPWT 1427
Query: 942 TCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWS 1001
+CS +C G++ R++ C+ + + E+ + V P +AC S CP W W+
Sbjct: 1428 SCSASCGKGRKYREVFCIDQFQRKLEDT---NCSQVQKPPTHKACRSVRCP-SWKANSWN 1483
Query: 1002 QCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSW 1061
+CS TCG GV++R++ C+ + E C RP Q C C ++ ++
Sbjct: 1484 ECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGME---RGR 1540
Query: 1062 SECSATCGLGVRKREMKCSEKG--------FQGKLITFPERRCRN--------------- 1098
CS +C + M+C++ + I+ + CRN
Sbjct: 1541 LNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQC 1600
Query: 1099 --------------------IKKPNLDLEETCNRRACPAHP---VYNMV------AGWYS 1129
KK L + CP P VY + A W
Sbjct: 1601 ANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKV 1660
Query: 1130 LPWQQCTVTCGGGVQTRSVHCV-QQGRPSSSCLLHQKPPVLRACNTNFC 1177
W +C+VTCG G+ R V C+ + G S CL H KP + C N C
Sbjct: 1661 GKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
Score = 72.4 bits (176), Expect = 2e-12
Identities = 54/212 (25%), Positives = 83/212 (39%), Gaps = 22/212 (10%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
+ECSV+CG G C QV C T+P ++ + + M
Sbjct: 1483 NECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLN 1542
Query: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQ 1002
CS +C ++++C + Q E V +S T C + C SQ
Sbjct: 1543 CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKN---CRNPPCNYIVVTADSSQ 1599
Query: 1003 CSKTCGRGVRKRELLC---------KGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSR 1053
C+ CG R+R C K + +C +P ++ + C+ NS
Sbjct: 1600 CANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQ-CI------NSC 1652
Query: 1054 LQ---WVASSWSECSATCGLGVRKREMKCSEK 1082
L W WS+CS TCG+G+ KR++KC K
Sbjct: 1653 LHLATWKVGKWSKCSVTCGIGIMKRQVKCITK 1684
Score = 38.5 bits (88), Expect = 0.040
Identities = 24/89 (26%), Positives = 38/89 (42%), Gaps = 4/89 (4%)
Query: 1110 CNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVL 1169
C + PV W P+ C+ TCGGG+++ + C + + +
Sbjct: 545 CVNKETETRPVNGEWGPWE--PYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKF 602
Query: 1170 RACNTNFCP-APEKREDPSCVDFFNWCHL 1197
R+CNT+ CP + + C D FN HL
Sbjct: 603 RSCNTDSCPKGTQDFREKQCSD-FNGKHL 630
Score = 38.1 bits (87), Expect = 0.052
Identities = 18/41 (43%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Query: 582 ELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ 622
+ GP P QW+ + W ECS+TCGGG+K + C P Q
Sbjct: 1353 QCGPGPCP-QWN-YGNWGECSQTCGGGIKSRLVICQFPNGQ 1391
Score = 31.6 bits (70), Expect = 4.8
Identities = 12/25 (48%), Positives = 18/25 (72%), Gaps = 1/25 (4%)
Query: 592 WSAWSKWSECSRTCGGGVKFQERHC 616
W A + W+ECS TCG GV+ ++ +C
Sbjct: 1477 WKA-NSWNECSVTCGSGVQQRDVYC 1500
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 543 bits (1399), Expect = e-154
Identities = 360/1066 (33%), Positives = 496/1066 (46%), Gaps = 150/1066 (14%)
Query: 90 AQNARSSLHYRFSAFGQELHLELKPSA-ILSSHFIVQVLGKDGASETQKPEVQQCFYQGF 148
A+ +L AFG++L+L+L+ LS F V+ + GA+ + + CFY G
Sbjct: 74 ARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVE---EAGAARRRGRPAELCFYSGR 130
Query: 149 IRNDSSSSVAVSTCA---GLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKR 205
+ S V++S C GL GLI+ + + LI PL +N P H++ ++
Sbjct: 131 VLGHPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPL-------NNSQGPFSGREHLIRRK 183
Query: 206 TAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPP 265
+S + P A R + +K KK P
Sbjct: 184 ---------------------WSLTPSPSAEAQRPEQLCKVLTEK-------KKPTWGRP 215
Query: 266 TEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMV 325
+ D R RR+A + VETLVVAD MV+ HG +ILTVMNMV
Sbjct: 216 SRDW-----------RERRNAIRLTSEHTVETLVVADADMVQYHGAEAAQRFILTVMNMV 264
Query: 326 SGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRH-- 383
+F+ ++G IN+ V L+LL Q P L I HH ++SL SFC WQ+ G G R+
Sbjct: 265 YNMFQHQSLGIKINIQVTKLVLLRQRPAKLSIGHHGERSLESFCHWQNEEYG--GARYLG 322
Query: 384 --------------DHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLG 429
D A+ +T D C K+EPCDT+G A + G+CS R C + ED GL
Sbjct: 323 NNQVPGGKDDPPLVDAAVFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLN 382
Query: 430 LAFTIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNN-GVFSWSSCSRQYLKKFLST 488
LAFTIAHE GHN GM HD + + C + + G N SWSSCSR L+ FL +
Sbjct: 383 LAFTIAHELGHNLGMNHDDDHSSCAGRSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKS 442
Query: 489 PQAGC-LVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCH 547
+ C LV +P+ + P KLPG Y A+ QC+ FG A C +C LWC
Sbjct: 443 KVSTCLLVTDPRSQHTVRLPHKLPGMHYSANEQCQILFGMNATFCR-NMEHLMCAGLWCL 501
Query: 548 RVGH-RCETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCG 606
G C+TK P +GT CG WCR G+CV + P + G WS W WS CSRTCG
Sbjct: 502 VEGDTSCKTKLDPPLDGTECGADKWCRAGECVSKTPI-PEHVDGDWSPWGAWSMCSRTCG 560
Query: 607 GGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYN--SKPFR 664
G +F++R C+NP P GG CPG+S + +C PC + FR QQC ++ S +
Sbjct: 561 TGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHDRLSPKKK 620
Query: 665 GWFYQWKPYTKVEEEDR-CKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELV 723
G T V +D+ C+LYC E ++ +V DGTPC P + D+C+ G C+ +
Sbjct: 621 GLL------TAVVVDDKPCELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKI 674
Query: 724 GCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQ 783
GCD +GS A D CGVC GD TC KG + + AR +++
Sbjct: 675 GCDGIIGSAAKEDRCGVCSGDGKTCHLVKGDF----------------SHARGTALKD-- 716
Query: 784 VSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETL-V 842
S K + W I+ PGEF AGTT Y R E++ A GPT L +
Sbjct: 717 -----------SGKGSINSDWKIELPGEFQIAGTTVRYVRR-GLWEKISAKGPTKLPLHL 764
Query: 843 FEILMQGKNPGIAWKYALPKVMNGT------PPATKRPAYTWSIVQSE-CSVSCGGGYIN 895
+L ++ GI ++Y +P +N T P + + W+ E CSV CGGG
Sbjct: 765 MVLLFHDQDYGIHYEYTVP--VNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERR 822
Query: 896 VKAICLRDQN---TQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQ 952
C R N T VN S C ++P + + CN C + W+ G WS CS C G Q
Sbjct: 823 TIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQ 882
Query: 953 SRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVR 1012
R++ CV + A CP P VQ+C C W WSQCS +CG+GV
Sbjct: 883 HREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVW 942
Query: 1013 KRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGV 1072
KR + C S + +C + RP +E C + +W WS CS+TCG G+
Sbjct: 943 KRTVACTNS------QGKCDASTRPRAEEACE----DYSGCYEWKTGDWSTCSSTCGKGL 992
Query: 1073 RKREMKCSEK--GFQGKLITFPERRCRNIKKP---NLDLEETCNRR 1113
+ R ++C K G G C + KP +E CN R
Sbjct: 993 QSRVVQCMHKVTGRHGS-------ECPALSKPAPYRQCYQEVCNDR 1031
Score = 129 bits (324), Expect = 2e-29
Identities = 92/304 (30%), Positives = 128/304 (42%), Gaps = 48/304 (15%)
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST--PTQVQACNSHACP 992
W W CS C GG++ + C + + V S CP ++ QV+ CN H C
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVN-KTTTLVNDSDCPQASRPEPQVRRCNLHPCQ 862
Query: 993 PQWSLGPWSQCSKTCGRGVRKRELLC-----KGSAAETLPESQCTSLPRPELQEGCVLGR 1047
+W GPWS CS TC +G + RE+ C G+ T P C PRP + C
Sbjct: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRP-LYCPG-PRPAAVQSCEGQD 920
Query: 1048 CPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLE 1107
C W AS WS+CSA+CG GV KR + C+ QGK C +P E
Sbjct: 921 CLSI----WEASEWSQCSASCGKGVWKRTVACTNS--QGK--------CDASTRPRA--E 964
Query: 1108 ETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ--GRPSSSCLLHQK 1165
E C Y+ W + W C+ TCG G+Q+R V C+ + GR S C K
Sbjct: 965 EACED--------YSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSK 1016
Query: 1166 PPVLRAC---------NTNFCPAPEKREDPSCVDFFNW---CHLVPQHGVCNHKFYGKQC 1213
P R C N N +P W C ++ + +C + ++C
Sbjct: 1017 PAPYRQCYQEVCNDRINANTITSPRLAALTYKCTRDQWTVYCRVIREKNLCQDMRWYQRC 1076
Query: 1214 CKSC 1217
C++C
Sbjct: 1077 CQTC 1080
Score = 56.2 bits (134), Expect = 2e-07
Identities = 39/141 (27%), Positives = 53/141 (37%), Gaps = 22/141 (15%)
Query: 1049 PKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFP-ERRCRNIKKPNLDLE 1107
P++S W S W CS CG G R+ + C+ K T + C +P +
Sbjct: 797 PQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTR--IVNKTTTLVNDSDCPQASRPEPQV- 853
Query: 1108 ETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPP 1167
R C HP + W + PW C+ TC G Q R V CV Q + +
Sbjct: 854 -----RRCNLHPCQSR---WVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHV------- 898
Query: 1168 VLRACNTNFCPAPEKREDPSC 1188
A +CP P SC
Sbjct: 899 ---ATRPLYCPGPRPAAVQSC 916
Score = 36.6 bits (83), Expect = 0.15
Identities = 41/163 (25%), Positives = 60/163 (36%), Gaps = 35/163 (21%)
Query: 541 CKSLWCHRVGHRCETKFMPAAEGTVCGLSMWCR-------QGQCVKFGELGPRPIHG--- 590
C S+W +C CG +W R QG+C PR
Sbjct: 921 CLSIWEASEWSQCSAS---------CGKGVWKRTVACTNSQGKCD--ASTRPRAEEACED 969
Query: 591 -----QWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSR--IYQLCNINPC 643
+W WS CS TCG G++ + C + G CP S+ Y+ C C
Sbjct: 970 YSGCYEWKT-GDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVC 1028
Query: 644 NE--NSLDFRAQQCAEYNSKPFRGWFYQWKPYTKV-EEEDRCK 683
N+ N+ + + A K R QW Y +V E++ C+
Sbjct: 1029 NDRINANTITSPRLAALTYKCTRD---QWTVYCRVIREKNLCQ 1068
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 535 bits (1379), Expect = e-152
Identities = 348/1024 (33%), Positives = 476/1024 (46%), Gaps = 115/1024 (11%)
Query: 100 RFSAFGQELHLELKPSA-ILSSHFIVQVL-----GKDGASETQKPEVQQ---CFYQGFIR 150
R AF ++L+L L+ L+ F V+ G GA+ +P CFY G +
Sbjct: 168 RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVL 227
Query: 151 NDSSSSVAVSTCAG-LSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLY--KRTA 207
S + STC G L G I+ ++ I PL +A HPH +Y KR+
Sbjct: 228 RHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTMA--------ITGHPHRVYRQKRSM 279
Query: 208 EEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGR-RKKYAPKPPT 266
EEK+ + ++ H H+CG K P
Sbjct: 280 EEKV--------------------------TEKSALH------SHYCGIISDKGRP---- 303
Query: 267 EDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVS 326
R + SGR +R + K + N+ET+VVAD MV HG +ILT++NMV
Sbjct: 304 -----RSRKIAESGRGKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVF 358
Query: 327 GLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRH--- 383
LF+ ++ +N+ V+ LILL + P L I HH ++ L SFC+WQ GK H
Sbjct: 359 NLFQHKSLSVQVNLRVIKLILLHETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEM 418
Query: 384 -----------DHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAF 432
D AIL+T D C K+EPCDT+G A +SGMCS+ R C I ED GL LAF
Sbjct: 419 STNWGEDMTSVDAAILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAF 478
Query: 433 TIAHESGHNFGMIHDGEGNPCRKAEGNIMSPTLTGNN-GVFSWSSCSRQYLKKFLSTPQA 491
TIAHE GHN G+ HD + C + + G N G SWS CS++ L++FL + +
Sbjct: 479 TIAHEMGHNMGINHDNDHPSCADGLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKAS 538
Query: 492 GCLVD-EPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVG 550
CL+ P+ P KLPG Y AD QC+ FG A C IC LWC G
Sbjct: 539 NCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFCQ-EMQHVICTGLWCKVEG 597
Query: 551 HR-CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGV 609
+ C TK P +GT C L WC+ G+C P + G+WS WS CSRTC G+
Sbjct: 598 EKECRTKLDPPMDGTDCDLGKWCKAGECTS-RTSAPEHLAGEWSL---WSPCSRTCSAGI 653
Query: 610 KFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYN---SKPFRGW 666
+ER C P C G + Y++C PC FR QC Y+ S P
Sbjct: 654 SSRERKC--PGLDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKH-- 709
Query: 667 FYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCD 726
QW+ ++EE C L+C E +S KV DGT C D+C +G C+ VGCD
Sbjct: 710 ILQWQ--AVLDEEKPCALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCD 767
Query: 727 HELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSS 786
LGS A D CGVC G+ +CK KG + N + Y V++IPAGAR I++ E + +
Sbjct: 768 GLLGSLAREDHCGVCNGNGKSCKIIKGDF-NHTRGAGYVEVLVIPAGARRIKVVEEKPAH 826
Query: 787 SYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETL-VFEI 845
SYLA+R + K + W I+ G F AGTT Y R E++ A GPT L + +
Sbjct: 827 SYLALRD-AGKQSINSDWKIEHSGAFNLAGTTVHYVRR-GLWEKISAKGPTTAPLHLLVL 884
Query: 846 LMQGKNPGIAWKYALPK--VMNGTPPATKRPAYTWSIVQ-SECSVSCGGGYINVKAICLR 902
L Q +N G+ ++Y +P + P + W+ +C +CGGG C +
Sbjct: 885 LFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTK 944
Query: 903 DQNTQ---VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCV 959
+ V++ C TKP + + CN C WM EW+ CS+ C G QSR++ C
Sbjct: 945 IMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACT 1004
Query: 960 QKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCK 1019
Q+ C P Q C C W G WS+CS CG+G+R R + C
Sbjct: 1005 QQLSNGTLIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRC- 1063
Query: 1020 GSAAETLPESQCTSLPRPELQEGCV-LGRCPKNSRLQWVASSWSECSATCGLGVRKREMK 1078
T P +C RP E C +C W WS+CS TCG G++ R ++
Sbjct: 1064 -----TNPRKKCVLSTRPREAEDCEDYSKC-----YVWRMGDWSKCSITCGKGMQSRVIQ 1113
Query: 1079 CSEK 1082
C K
Sbjct: 1114 CMHK 1117
Score = 89.7 bits (221), Expect = 1e-17
Identities = 57/215 (26%), Positives = 96/215 (44%), Gaps = 24/215 (11%)
Query: 964 FQKEEAVLHSLCPVSTPTQVQACNSHACPP--QWSLGPWSQCSKTCGRGVRKRELLCKGS 1021
FQ + LH + + + +S A P W+ W C TCG G RK + C
Sbjct: 886 FQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKI 945
Query: 1022 AAETLP---ESQCTSLPRPELQEGCVLGRCPKNS-RLQWVASSWSECSATCGLGVRKREM 1077
++ + +C L +PE Q + +C + + +W+ + W+ CS TCG G++ R++
Sbjct: 946 MSKNISIVDNEKCKYLTKPEPQ----IRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQV 1001
Query: 1078 KCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTV 1137
C+++ G LI ER C K + + C + C + W + W +C+V
Sbjct: 1002 ACTQQLSNGTLIRARERDCIGPKPAS---AQRCEGQDC--------MTVWEAGVWSECSV 1050
Query: 1138 TCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRAC 1172
CG G++ R+V C P C+L +P C
Sbjct: 1051 KCGKGIRHRTVRCT---NPRKKCVLSTRPREAEDC 1082
Score = 45.4 bits (106), Expect = 3e-04
Identities = 47/189 (24%), Positives = 73/189 (38%), Gaps = 36/189 (19%)
Query: 935 WMPGE------WSTCSKA-CAGGQQSRKIQCV-QKKPFQKEEAVLHSLCPVSTPTQVQAC 986
W+ G+ WS CSK +S+ C+ Q P ++ S P T T + C
Sbjct: 510 WIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQC 569
Query: 987 NSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQC-TSLPRP------EL 1039
Q GP + + + ++C G + E +C T L P +L
Sbjct: 570 -------QILFGPLASFCQ------EMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDL 616
Query: 1040 QEGCVLGRC------PKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPE 1093
+ C G C P++ +W S WS CS TC G+ RE KC + + P
Sbjct: 617 GKWCKAGECTSRTSAPEHLAGEW--SLWSPCSRTCSAGISSRERKCPGLDSEARDCNGPR 674
Query: 1094 RRCRNIKKP 1102
++ R + P
Sbjct: 675 KQYRICENP 683
Score = 38.5 bits (88), Expect = 0.040
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 4/89 (4%)
Query: 598 WSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSR--IYQLCNINPCNENSLDFRAQQC 655
WS+CS TCG G++ + C + G C S + Y+ C++ PCNE ++
Sbjct: 1096 WSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQPCNE-KINVNTITS 1154
Query: 656 AEYNSKPFRGWFYQWKPYTKV-EEEDRCK 683
+ F+ QW Y +V E++ C+
Sbjct: 1155 PRLAALTFKCLGDQWPVYCRVIREKNLCQ 1183
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 535 bits (1377), Expect = e-151
Identities = 343/1034 (33%), Positives = 505/1034 (48%), Gaps = 104/1034 (10%)
Query: 60 DYVFVTPVEVDSAGSYISHDILHNGRKKRSAQNARSS---LHYRFSAFGQELHLELKPS- 115
+Y VTPV + G Y+SH L KKRSA++ S+ L + +AFG++ HL LKP+
Sbjct: 41 EYELVTPVSTNLEGRYLSHT-LSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRLKPNT 99
Query: 116 ------AILSSHFIVQVLGK--DGASETQ-----------KPEVQQCFYQGFIRNDSSSS 156
A++ H V G D + Q +P C Y G I + +S
Sbjct: 100 QLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDIPGTS 159
Query: 157 VAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRG 216
VA+S C GL+G+I++ E+ I PL + E HV+YKR+A E+
Sbjct: 160 VAISNCDGLAGMIKSDNEEYFIEPLERGKQMEEEKG-----RIHVVYKRSAVEQ------ 208
Query: 217 YPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEY 276
A ++H+R + Y + + + +E
Sbjct: 209 ------------------APIDMSKDFHYRESDLEGLDDLGTVYG------NIHQQLNE- 243
Query: 277 GSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGS 336
+ R RR AG++ N+E L+ D +V HGK +V Y+LT+MN+V+ ++ D ++G
Sbjct: 244 --TMRRRRHAGEND--YNIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGV 299
Query: 337 DINVVVVSLILLEQEPGGLLINH-HADQSLNSFCQWQSALIGKN---GKRHDHAILLTGF 392
INVV+V +I+L LI + +SL + C+W S + + HDHAI LT
Sbjct: 300 HINVVLVRMIMLGYAKSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQ 359
Query: 393 DICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNP 452
D P G+AP++GMC RSCT+N + G AF +AHE+GH GM HDG+GN
Sbjct: 360 DF-----GPAGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNR 414
Query: 453 C--RKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKL 510
C A G++M+P + + WS CS Q LK+++ + CL+D+P K P+ L
Sbjct: 415 CGDETAMGSVMAPLVQAAFHRYHWSRCSGQELKRYIHSYD--CLLDDPFDHDWPKLPE-L 471
Query: 511 PGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR--CETKFMPAAEGTVCGL 568
PG Y D QC++ FG K+C+ D CK LWC + C+TK P +GT C
Sbjct: 472 PGINYSMDEQCRFDFGVGYKMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAA 531
Query: 569 SMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFC 628
WC +G C+ + + G W +W+K+ CSRTCG GV+F+ R CNNP P GG C
Sbjct: 532 GKWCYKGHCM-WKNANQQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDC 590
Query: 629 PGSSRIYQLCNINPCNENSLDFRAQQCAEYNSK-PFRGWFYQWKPYTKVEEEDRCKLYCK 687
PG + YQLCN C ++ DFRAQQC + NS ++ + W PY + + RC LYC+
Sbjct: 591 PGVNFEYQLCNTEECQKHFEDFRAQQCQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQ 650
Query: 688 AENFEFFFAMSGKVKDGTPCS-PNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNS 746
++ M V DGT CS + +C+ G C VGCD E+GS V D CGVC GDNS
Sbjct: 651 SKETGDVAYMKQLVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNS 710
Query: 747 TCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSI 806
C+ KG + + Y + IP GAR + IQE + S LA+++ + +Y+ G
Sbjct: 711 HCRTVKGTFTRTPRKLGYLKMFDIPPGARHVLIQEDEASPHILAIKNQATGHYILNGKGE 770
Query: 807 DWPGE-FPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKN--PGIAWKY----- 858
+ F G ++Y + E L+ GP ++ ++ I+ Q + + +KY
Sbjct: 771 EAKSRTFIDLGVEWDYNIE-DDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHED 829
Query: 859 ALPKVMNGTPPATKRPAYTWSIVQ-SECSVSCGGGYINVKAICLR-DQNTQVNSSFCSAK 916
++P + + + + W++ S+CS CGGG+ K C R N V+ SFC A
Sbjct: 830 SVPTINSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEAN 889
Query: 917 TKPVTEPKICNAFSCP-AYWMPGEWSTCSKAC-AGGQQSRKIQCVQKKPFQKEEAVLHSL 974
KP ++CN C W+ EW C+K C + G Q R ++C+Q +V
Sbjct: 890 KKPKPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKY 949
Query: 975 CPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSL 1034
C P + CN CP QW GPWS+CS TCG G R++LC+ C
Sbjct: 950 CMGDRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCRAG-------DHCDG- 1001
Query: 1035 PRPELQEGCVLGRC 1048
+PE C L C
Sbjct: 1002 EKPESVRACQLPPC 1015
Score = 103 bits (257), Expect = 1e-21
Identities = 67/230 (29%), Positives = 105/230 (45%), Gaps = 27/230 (11%)
Query: 994 QWSLGPWSQCSKTCGRGVRKRELLCKG-SAAETLPESQCTSLPRPE-LQEGCVLGRCPKN 1051
+W+L WSQCSK CG G + + C+ S + + S C + +P+ ++ C + C
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQEC--- 904
Query: 1052 SRLQWVASSWSECSATCGL-GVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
+ WVA W C+ TCG G + R ++C + G + + C + + C
Sbjct: 905 THPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPES---RRPC 961
Query: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLR 1170
NR CPA W + PW +C+VTCG G + R V C R C +KP +R
Sbjct: 962 NRVPCPAQ--------WKTGPWSECSVTCGEGTEVRQVLC----RAGDHC-DGEKPESVR 1008
Query: 1171 ACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSCTRK 1220
AC P ++P D +C + C+ Y K CC+SC+++
Sbjct: 1009 ACQ-----LPPCNDEPCLGDKSIFCQMEVLARYCSIPGYNKLCCESCSKR 1053
Score = 31.6 bits (70), Expect = 4.8
Identities = 21/70 (30%), Positives = 29/70 (41%), Gaps = 13/70 (18%)
Query: 1018 CKGSAAETLPESQCTSLPRPELQEGCVLGRCP-KNSRLQWVASSWSE------CSATCGL 1070
CK L ++C + + C G C KN+ Q +W CS TCG
Sbjct: 516 CKTKKGPPLDGTECAA------GKWCYKGHCMWKNANQQKQDGNWGSWTKFGSCSRTCGT 569
Query: 1071 GVRKREMKCS 1080
GVR R +C+
Sbjct: 570 GVRFRTRQCN 579
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 514 bits (1324), Expect = e-145
Identities = 346/1054 (32%), Positives = 510/1054 (48%), Gaps = 99/1054 (9%)
Query: 40 ASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDIL----HNGRKKRSAQNAR- 94
A+ A A+D G G + + PV D+ G +SH + G + R A R
Sbjct: 35 ANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRT 94
Query: 95 ------------SSLHYRFSAFGQELHLELKPSA-ILSSHFIVQVLGKDGASETQKPEVQ 141
S L Y + FG++LHL L+P+A +++ ++ G+ G + + P +
Sbjct: 95 PSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVE-PLLG 153
Query: 142 QCFYQGFIRN-DSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPH 200
C Y G + +SSVA+S C GL+GLIR + EF I PL + LA + H
Sbjct: 154 SCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRV----H 209
Query: 201 VLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKY 260
V+Y+R P P + + + R L
Sbjct: 210 VVYRRPPTSP--------------PLGGPQALDTGASLDSLDSLSRALGV---------- 245
Query: 261 APKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILT 320
+E+ +S R R + N+E L+ D +V+ HGK +V Y+LT
Sbjct: 246 ------------LEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLT 293
Query: 321 VMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLIN-HHADQSLNSFCQW---QSALI 376
+MN+V+ ++ D ++G+ INVV+V +ILL LI + QSL + C+W Q
Sbjct: 294 LMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPD 353
Query: 377 GKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAH 436
+ + HDHAI LT D P G+AP++GMC RSCT+N + G AF +AH
Sbjct: 354 TGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAH 408
Query: 437 ESGHNFGMIHDGEGNPCRKAE--GNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCL 494
E+GH GM HDG+GN C G+IM+P + F WS CS+Q L ++L + CL
Sbjct: 409 ETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYD--CL 466
Query: 495 VDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR-- 552
+D+P A + +LPG Y + QC++ FG +C+ D CK LWC +
Sbjct: 467 LDDPF-AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF 525
Query: 553 CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIH--GQWSAWSKWSECSRTCGGGVK 610
C+TK P +GT+C C +G C+ L P + G W AWS + CSRTCG GVK
Sbjct: 526 CKTKKGPPLDGTMCAPGKHCFKGHCIW---LTPDILKRDGSWGAWSPFGSCSRTCGTGVK 582
Query: 611 FQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRG-WFYQ 669
F+ R C+NP P GG C G + +QLC+ C ++ DFR +QC +++ G +
Sbjct: 583 FRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHH 642
Query: 670 WKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCS-PNKNDVCIDGVCELVGCDHE 728
W P+ + ++RC LYC++ +M V DGT CS + +C+ G C VGCD
Sbjct: 643 WLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGV 702
Query: 729 LGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSY 788
+GS D CGVC GDNS CK KG + K + Y + IPAGAR + IQE+ +S +
Sbjct: 703 IGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHH 762
Query: 789 LAVRSL-SQKYYLTGGWSIDWPGE-FPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEIL 846
LAV++L + K+ L +D + F G +EY+ R E L GP + T+ ++
Sbjct: 763 LAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGR-ETLQTMGPLHGTITVLVI 821
Query: 847 MQG-KNPGIAWKYALPK----VMNGTPPATKRPAYTWSIVQ-SECSVSCGGGYINVKAIC 900
G + +KY + + V + Y W++ + S CS CGGG K C
Sbjct: 822 PVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGC 881
Query: 901 LRD-QNTQVNSSFCSAKTKPVTEPKICNAFSC-PAYWMPGEWSTCSKACA-GGQQSRKIQ 957
R + V+ FC+A +KP + CN C W+ GEW CS+ C G Q R ++
Sbjct: 882 RRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVR 941
Query: 958 CVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELL 1017
C+Q +V C + P +AC+ CP +W GPWSQCS TCG G ++R +L
Sbjct: 942 CIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVL 1001
Query: 1018 CKGSAAETLPESQCTSLPRPELQEGCVLGRCPKN 1051
C+ +A ++ Q RPE C LG CP+N
Sbjct: 1002 CR-TADDSFGICQ---EERPETARTCRLGPCPRN 1031
Score = 95.9 bits (237), Expect = 2e-19
Identities = 68/252 (26%), Positives = 99/252 (39%), Gaps = 43/252 (17%)
Query: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQ-CTSLPRPE-LQEGCVLGRCPKN 1051
+W+L WS CSK CG G + + C+ + C +L +P+ ++ C C
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC--- 913
Query: 1052 SRLQWVASSWSECSATCG-LGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
S+ WV W CS TCG G++ R ++C + + + C + + + C
Sbjct: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPES---RRAC 970
Query: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLR 1170
+R CP W + PW QC+VTCG G Q R V C + S ++P R
Sbjct: 971 SRELCPGR--------WRAGPWSQCSVTCGNGTQERPVLC-RTADDSFGICQEERPETAR 1021
Query: 1171 ACNTNFCPA----PEK---------REDPSCV------------DFFNWCHLVPQHGVCN 1205
C CP P K R DP D +C + C+
Sbjct: 1022 TCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCS 1081
Query: 1206 HKFYGKQCCKSC 1217
Y K CCKSC
Sbjct: 1082 IPGYNKLCCKSC 1093
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 496 bits (1277), Expect = e-140
Identities = 343/1102 (31%), Positives = 497/1102 (45%), Gaps = 125/1102 (11%)
Query: 37 LCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDI---------------- 80
L CA AAA + SG DY P D G ++SH +
Sbjct: 14 LHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTP 73
Query: 81 ----------------LHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSSHFIV 124
LH G + R SL++ + FG+ELHL L+P+ L
Sbjct: 74 PTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSS 133
Query: 125 QVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQL 184
+D ++P Q+C Y G + ++VA+S C GL+GLIRT +F I PL
Sbjct: 134 VEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPL--- 190
Query: 185 LAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYH 244
+ A HV+Y+R E +Q+ P + + +P+
Sbjct: 191 --ERGQQEKEASGRTHVVYRR---EAVQQEWAEPDGDLHNEAFGLGDLPNLLG------- 238
Query: 245 HRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKK 304
L D+ G + R RR A ++E L+V D
Sbjct: 239 --------------------------LVGDQLGDTERKRRHAKPGS--YSIEVLLVVDDS 270
Query: 305 MVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINH-HADQ 363
+V HGK +V Y+LT+MN+V ++ D ++G IN+ +V LI++ LI + +
Sbjct: 271 VVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSR 330
Query: 364 SLNSFCQW---QSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC 420
SL C+W Q + + HDH + LT D P G+AP++GMC RSC
Sbjct: 331 SLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF-----GPSGMQGYAPVTGMCHPLRSC 385
Query: 421 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPC--RKAEGNIMSPTLTGNNGVFSWSSCS 478
+N + G AF IAHE+GH GM HDG+GN C + G++M+P + F WS CS
Sbjct: 386 ALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCS 445
Query: 479 RQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVK 538
+ L ++L P CL+D+P + P +LPG Y D QC++ FG+ + C
Sbjct: 446 KLELSRYL--PSYDCLLDDPFDPA-WPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTF 502
Query: 539 DICKSLWCHRVGHR--CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQ---WS 593
+ CK LWC + C+TK P +GT C WC +G C+ P +GQ WS
Sbjct: 503 EPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW---KSPEQTYGQDGGWS 559
Query: 594 AWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQ 653
+W+K+ CSR+CGGGV+ + R CNNP P YGG C G YQ+CN C DFRAQ
Sbjct: 560 SWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQ 619
Query: 654 QCAEYNS-KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCS-PNK 711
QCA+ NS + + W PY ++ +C+L C++ + M+ V DGT CS +
Sbjct: 620 QCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDP 679
Query: 712 NDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIP 771
VC G C VGCD E+GS D CGVC GDNS C+ KG K +V IP
Sbjct: 680 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIP 739
Query: 772 AGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGE----FPFAGTTFEYQRSF-N 826
AGAR I+I+ L+ S + V K +TG + ++ G+ F E++ + +
Sbjct: 740 AGARHIQIEALEKSPHRIVV-----KNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVED 794
Query: 827 RPERLYAPGPTNETLVFEILMQ---GKNPGIAWKYA-----LPKVMNGTPPATKRPAYTW 878
E L GP E + L G +A+KY LP + + + Y W
Sbjct: 795 AKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEW 854
Query: 879 SIVQ-SECSVSCGGGYINVKAICLRDQ-NTQVNSSFCSAKTKPVTEPKICNAFSC-PAYW 935
++ + CS +CGGG K C R + + V C K +P + CN C W
Sbjct: 855 ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVW 914
Query: 936 MPGEWSTCSKACAG-GQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQ 994
+ EW CS++C G Q+R IQC+ + + C P + C CP Q
Sbjct: 915 VTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQ 974
Query: 995 WSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRL 1054
W LG WSQCS TCG G+++R+++C+ +A C RP+ + C L C N +
Sbjct: 975 WRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEG-DRPDTVQVCSLPACGGNHQN 1030
Query: 1055 QWVASSWSECSATCGLGVRKRE 1076
V + E G V + E
Sbjct: 1031 STVRADVWELGTPEGQWVPQSE 1052
Score = 81.3 bits (199), Expect = 5e-15
Identities = 66/265 (24%), Positives = 101/265 (38%), Gaps = 56/265 (21%)
Query: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQ-CTSLPRPE-LQEGCVLGRCPKN 1051
+W+L W+ CSK CG G++ + C+ + + C RP+ ++ C C
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC--- 909
Query: 1052 SRLQWVASSWSECSATCG-LGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
S+ WV W CS +CG LGV+ R ++C G P + C + + C
Sbjct: 910 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP---EARRPC 966
Query: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLH---QKPP 1167
R CPA W W QC+ TCG G+Q R V C R +++ L H +P
Sbjct: 967 LRVPCPAQ--------WRLGAWSQCSATCGEGIQQRQVVC----RTNANSLGHCEGDRPD 1014
Query: 1168 VLRACNTNFC----------------PAPE----------------KREDPSCVDFFNWC 1195
++ C+ C PE +P D +C
Sbjct: 1015 TVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFC 1074
Query: 1196 HLVPQHGVCNHKFYGKQCCKSCTRK 1220
+ C+ Y + CC SC +K
Sbjct: 1075 QMEVLDRYCSIPGYHRLCCVSCIKK 1099
Score = 33.9 bits (76), Expect = 0.97
Identities = 25/92 (27%), Positives = 34/92 (36%), Gaps = 9/92 (9%)
Query: 1096 CRNIKKPNLDLEETCNRRAC--------PAHPVYNMVAGWYS-LPWQQCTVTCGGGVQTR 1146
C+ K P LD E + C Y GW S + C+ +CGGGV++R
Sbjct: 519 CKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSR 578
Query: 1147 SVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
S C L + CN+ CP
Sbjct: 579 SRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 610
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 493 bits (1270), Expect = e-139
Identities = 342/1102 (31%), Positives = 496/1102 (45%), Gaps = 128/1102 (11%)
Query: 37 LCCASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDI---------------- 80
L CA AAA + SG DY P D G ++SH +
Sbjct: 14 LHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDTP 73
Query: 81 ----------------LHNGRKKRSAQNARSSLHYRFSAFGQELHLELKPSAILSSHFIV 124
LH G + R SL++ + FG+ELHL L+P+ L
Sbjct: 74 PTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGSS 133
Query: 125 QVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQL 184
+D ++P Q+C Y G + ++VA+S C GL+GLIRT +F I PL
Sbjct: 134 VEWQEDFRELFRQPLRQECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPL--- 190
Query: 185 LAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYH 244
+ A HV+Y+R E +Q+ P + + +P+
Sbjct: 191 --ERGQQEKEASGRTHVVYRR---EAVQQEWAEPDGDLHNEAFGLGDLPNLLG------- 238
Query: 245 HRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKK 304
L D+ G + R RR A ++E L+V D
Sbjct: 239 --------------------------LVGDQLGDTERKRRHAKPGS--YSIEVLLVVDDS 270
Query: 305 MVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINH-HADQ 363
+V HGK +V Y+LT+MN+V ++ D ++G IN+ +V LI++ LI + +
Sbjct: 271 VVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSR 330
Query: 364 SLNSFCQW---QSALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSC 420
SL C+W Q + + HDH + LT D G+AP++GMC RSC
Sbjct: 331 SLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDF--------GPSGYAPVTGMCHPLRSC 382
Query: 421 TINEDTGLGLAFTIAHESGHNFGMIHDGEGNPC--RKAEGNIMSPTLTGNNGVFSWSSCS 478
+N + G AF IAHE+GH GM HDG+GN C + G++M+P + F WS CS
Sbjct: 383 ALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVMAPLVQAAFHRFHWSRCS 442
Query: 479 RQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVK 538
+ L ++L P CL+D+P + P +LPG Y D QC++ FG+ + C
Sbjct: 443 KLELSRYL--PSYDCLLDDPFDPA-WPQPPELPGINYSMDEQCRFDFGSGYQTCLAFRTF 499
Query: 539 DICKSLWCHRVGHR--CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQ---WS 593
+ CK LWC + C+TK P +GT C WC +G C+ P +GQ WS
Sbjct: 500 EPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIW---KSPEQTYGQDGGWS 556
Query: 594 AWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQ 653
+W+K+ CSR+CGGGV+ + R CNNP P YGG C G YQ+CN C DFRAQ
Sbjct: 557 SWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQ 616
Query: 654 QCAEYNS-KPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCS-PNK 711
QCA+ NS + + W PY ++ +C+L C++ + M+ V DGT CS +
Sbjct: 617 QCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCSYRDP 676
Query: 712 NDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIP 771
VC G C VGCD E+GS D CGVC GDNS C+ KG K +V IP
Sbjct: 677 YSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQAGALKLVQIP 736
Query: 772 AGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGE----FPFAGTTFEYQRSF-N 826
AGAR I+I+ L+ S + V K +TG + ++ G+ F E++ + +
Sbjct: 737 AGARHIQIEALEKSPHRIVV-----KNQVTGSFILNPKGKEATSRTFTAMGLEWEDAVED 791
Query: 827 RPERLYAPGPTNETLVFEILMQ---GKNPGIAWKYA-----LPKVMNGTPPATKRPAYTW 878
E L GP E + L G +A+KY LP + + + Y W
Sbjct: 792 AKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLEEMDTYEW 851
Query: 879 SIVQ-SECSVSCGGGYINVKAICLRDQ-NTQVNSSFCSAKTKPVTEPKICNAFSC-PAYW 935
++ + CS +CGGG K C R + + V C K +P + CN C W
Sbjct: 852 ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVW 911
Query: 936 MPGEWSTCSKACAG-GQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQ 994
+ EW CS++C G Q+R IQC+ + + C P + C CP Q
Sbjct: 912 VTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPAQ 971
Query: 995 WSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRL 1054
W LG WSQCS TCG G+++R+++C+ +A C RP+ + C L C N +
Sbjct: 972 WRLGAWSQCSATCGEGIQQRQVVCRTNANSL---GHCEG-DRPDTVQVCSLPACGGNHQN 1027
Query: 1055 QWVASSWSECSATCGLGVRKRE 1076
V + E G V + E
Sbjct: 1028 STVRADVWELGTPEGQWVPQSE 1049
Score = 81.3 bits (199), Expect = 5e-15
Identities = 66/265 (24%), Positives = 101/265 (38%), Gaps = 56/265 (21%)
Query: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQ-CTSLPRPE-LQEGCVLGRCPKN 1051
+W+L W+ CSK CG G++ + C+ + + C RP+ ++ C C
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC--- 906
Query: 1052 SRLQWVASSWSECSATCG-LGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
S+ WV W CS +CG LGV+ R ++C G P + C + + C
Sbjct: 907 SQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRP---EARRPC 963
Query: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLH---QKPP 1167
R CPA W W QC+ TCG G+Q R V C R +++ L H +P
Sbjct: 964 LRVPCPAQ--------WRLGAWSQCSATCGEGIQQRQVVC----RTNANSLGHCEGDRPD 1011
Query: 1168 VLRACNTNFC----------------PAPE----------------KREDPSCVDFFNWC 1195
++ C+ C PE +P D +C
Sbjct: 1012 TVQVCSLPACGGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFC 1071
Query: 1196 HLVPQHGVCNHKFYGKQCCKSCTRK 1220
+ C+ Y + CC SC +K
Sbjct: 1072 QMEVLDRYCSIPGYHRLCCVSCIKK 1096
Score = 33.9 bits (76), Expect = 0.97
Identities = 25/92 (27%), Positives = 34/92 (36%), Gaps = 9/92 (9%)
Query: 1096 CRNIKKPNLDLEETCNRRAC--------PAHPVYNMVAGWYS-LPWQQCTVTCGGGVQTR 1146
C+ K P LD E + C Y GW S + C+ +CGGGV++R
Sbjct: 516 CKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSR 575
Query: 1147 SVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
S C L + CN+ CP
Sbjct: 576 SRSCNNPSPAYGGRLCLGPMFEYQVCNSEECP 607
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif, 1
preproprotein [Homo sapiens]
Length = 967
Score = 463 bits (1192), Expect = e-130
Identities = 310/983 (31%), Positives = 446/983 (45%), Gaps = 127/983 (12%)
Query: 100 RFSAFGQELHLELKP-SAILSSHFIVQVLGKDGASETQKPEVQ--QCFYQGFIRNDSSSS 156
R AF Q+L LEL+P S+ L+ F +Q +G+ SET PE CFY G + D SS+
Sbjct: 77 RLHAFDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNGDPSSA 136
Query: 157 VAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHV-----LYKRTAEEKI 211
A+S C G+ G + I PLP A E ++ G P L +R + +
Sbjct: 137 AALSLCEGVRGAFYLLGEAYFIQPLPA--ASERLATAAPGEKPPAPLQFHLLRRNRQGDV 194
Query: 212 QRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYL 271
G G + + E E Q G + PT +
Sbjct: 195 GGTCGVVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQ------PTGTGSI 248
Query: 272 RFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKD 331
R + SS R VET++VAD+ M E HG G + Y+LT+ ++ + L+K
Sbjct: 249 RKKRFVSSHR------------YVETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKH 295
Query: 332 GTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQ---SALIGKNGKRHDHAIL 388
+I + +++VVV ++++ E G + +A +L +FC WQ + ++ + +D AIL
Sbjct: 296 PSIRNSVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAIL 355
Query: 389 LTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 448
T D+C ++ CDTLG A + +C RSC++ ED GL AFT AHE GH F M HD
Sbjct: 356 FTRQDLCG--SQTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD- 412
Query: 449 EGNPCRKAEG-----NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQ 503
+ C G ++M+ L+ + WS CS + FL CL+D+P+ Q
Sbjct: 413 DAKQCASLNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPIQ 472
Query: 504 YKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR---CETKFMPA 560
P LPG YDA+ QC++ FG +K C C +LWC C+TK P
Sbjct: 473 L--PGDLPGTSYDANRQCQFTFGEDSKHCP--DAASTCSTLWCTGTSGGVLVCQTKHFPW 528
Query: 561 AEGTVCGLSMWCRQGQCVKFGELG--PRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNN 618
A+GT CG WC G+CV + P HG W W W +CSRTCGGGV++ R C+N
Sbjct: 529 ADGTSCGEGKWCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDN 588
Query: 619 PKPQYGGLFCPGSSRIYQLCNINPCNENS-LDFRAQQCAEYN--SKPF--RGWFYQWKP- 672
P P+ GG +C G Y+ CN+ C +N+ FR +QC +N SK G +W P
Sbjct: 589 PVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPK 648
Query: 673 YTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSK 732
Y V +DRCKL C+A+ +FF + KV DGTPCSP+ VC+ G C GCD + SK
Sbjct: 649 YAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSK 708
Query: 733 AVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQV-----SSS 787
D CGVC G+ STCK G + Y+ ++ IP GA +IE+++ + S
Sbjct: 709 KKFDKCGVCGGNGSTCKKISGSVTSAKPG--YHDIITIPTGATNIEVKQRNQRGSRNNGS 766
Query: 788 YLAVRSLSQKYYLTGGWSIDW-PGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEIL 846
+LA+++ Y L G +++ + + G Y S ER+ + P E L ++L
Sbjct: 767 FLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVL 826
Query: 847 MQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNT 906
G N P K YT+ + + + S
Sbjct: 827 TVG---------------NALRPKIK---YTYFVKKKKESF------------------- 849
Query: 907 QVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQK 966
NA + W+ EW CSK+C G Q R ++C
Sbjct: 850 --------------------NAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPA 889
Query: 967 EEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETL 1026
E P + C H CP QW LG WS CSKTCG+G +KR L C L
Sbjct: 890 SECAKEV-----KPASTRPCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVL 943
Query: 1027 PESQCTSLPRPE-LQEGCVLGRC 1048
C L +P+ + C + C
Sbjct: 944 SHESCDPLKKPKHFIDFCTMAEC 966
Score = 65.9 bits (159), Expect = 2e-10
Identities = 35/108 (32%), Positives = 51/108 (47%), Gaps = 11/108 (10%)
Query: 995 WSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRL 1054
W + W +CSK+C G ++R + C+ + P S+C +P C CP
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ--PASECAKEVKPASTRPCADHPCP----- 910
Query: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP 1102
QW WS CS TCG G +KR +KC G +++ C +KKP
Sbjct: 911 QWQLGEWSSCSKTCGKGYKKRSLKC--LSHDGGVLS--HESCDPLKKP 954
Score = 53.9 bits (128), Expect = 9e-07
Identities = 30/96 (31%), Positives = 41/96 (42%), Gaps = 17/96 (17%)
Query: 1056 WVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRAC 1115
WV W ECS +C LG ++R ++C + Q P C KP + R C
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQ------PASECAKEVKP-------ASTRPC 904
Query: 1116 PAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV 1151
HP W W C+ TCG G + RS+ C+
Sbjct: 905 ADHPCPQ----WQLGEWSSCSKTCGKGYKKRSLKCL 936
Score = 41.6 bits (96), Expect = 0.005
Identities = 22/65 (33%), Positives = 30/65 (46%), Gaps = 1/65 (1%)
Query: 1125 AGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGRPSSSCLLHQKPPVLRACNTNFCPAPEKR 1183
+ W W +C+ +C G Q R V C G+P+S C KP R C + CP +
Sbjct: 856 SAWVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLG 915
Query: 1184 EDPSC 1188
E SC
Sbjct: 916 EWSSC 920
Score = 35.4 bits (80), Expect = 0.33
Identities = 17/48 (35%), Positives = 20/48 (41%)
Query: 1131 PWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
PW C+ TCGGGVQ C + K R+CN CP
Sbjct: 567 PWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRSCNLEDCP 614
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 15 preproprotein [Homo
sapiens]
Length = 950
Score = 460 bits (1184), Expect = e-129
Identities = 332/1035 (32%), Positives = 467/1035 (45%), Gaps = 140/1035 (13%)
Query: 54 ASGLNDDYVFVTPVEVDSAGSYISHDILHNGRK---KRSAQNARSSLHYRFSAFGQELHL 110
A G + V P+ +D DI NGR+ + + L ++ +AF ++ +L
Sbjct: 16 AGGSEPEREVVVPIRLDP-------DI--NGRRYYWRGPEDSGDQGLIFQITAFQEDFYL 66
Query: 111 ELKPSA------ILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSSSVAVSTCAG 164
L P A + H V + G G S ++++CFY G + + S AVS C G
Sbjct: 67 HLTPDAQFLAPAFSTEHLGVPLQGLTGGSS----DLRRCFYSGDVNAEPDSFAAVSLCGG 122
Query: 165 LSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVLYKRTAEEKIQRYRGYPGSGRNY 224
L G R E++ISPLP A +S H + + RG PG
Sbjct: 123 LRGAFGYRGAEYVISPLPNASAPAAQRNSQGAH-------------LLQRRGVPGG---- 165
Query: 225 PGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRR 284
PS P + + ++ L+ Y P R +G S R RR
Sbjct: 166 ----PSGDPTSRCGVASGWNPAILRALD------PYKP---------RRAGFGES-RSRR 205
Query: 285 SAGKSQKGLN----VETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINV 340
+G++++ ++ VETLVVAD+ MV+ HG ++ Y+LT++ + L++ +I + IN+
Sbjct: 206 RSGRAKRFVSIPRYVETLVVADESMVKFHG-ADLEHYLLTLLATAARLYRHPSILNPINI 264
Query: 341 VVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRH----DHAILLTGFDICS 396
VVV ++LL G + +A +L +FC WQ L K +H D AIL T D+C
Sbjct: 265 VVVKVLLLRDRDSGPKVTGNAALTLRNFCAWQKKL-NKVSDKHPEYWDTAILFTRQDLCG 323
Query: 397 WKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKA 456
CDTLG A + MC RSC++ ED GL AFT AHE GH F M HD C +
Sbjct: 324 ATT--CDTLGMADVGTMCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNV-KVCEEV 380
Query: 457 EGNI-----MSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLP 511
G + MSPTL + WS+CS + FL + CL+D+P + P+ LP
Sbjct: 381 FGKLRANHMMSPTLIQIDRANPWSACSAAIITDFLDSGHGDCLLDQPSKP--ISLPEDLP 438
Query: 512 GQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR---CETKFMPAAEGTVCGL 568
G Y QC+ FG +K C C LWC C+T+ P A+GT CG
Sbjct: 439 GASYTLSQQCELAFGVGSKPCPY---MQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGE 495
Query: 569 SMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFC 628
C +G CV+ L + G W+ W + CSRTCGGGV+ R C NP P GG +C
Sbjct: 496 GKLCLKGACVERHNLNKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYC 555
Query: 629 PGSSRIYQLCNINPC--NENSLDFRAQQCAEYN----SKPFRGWFYQWKP-YTKVEEEDR 681
G Y+ CN+ PC + + FR +QC +N S W P Y+ V D+
Sbjct: 556 EGVRVKYRSCNLEPCPSSASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDK 615
Query: 682 CKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVC 741
CKL C+A +F+ ++ KV DGT CSP+ VC+ G C GCD LGSK D CGVC
Sbjct: 616 CKLICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVC 675
Query: 742 KGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQE-----LQVSSSYLAVRSLSQ 796
GDN +CK GL+ + Y VV IPAGA SI+I++ L +YLA+++
Sbjct: 676 GGDNKSCKKVTGLFTKP--MHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQG 733
Query: 797 KYYLTGGWSIDW-PGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEILMQGKN--PG 853
KY L G + + + G+ Y + E L A P E L E+L GK P
Sbjct: 734 KYLLNGHFVVSAVERDLVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPR 793
Query: 854 IAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFC 913
+ + + LPK P K S G ++ + L +Q Q
Sbjct: 794 VRYSFYLPK----EPREDK---------SSHPKDPRGPSVLHNSVLSLSNQVEQ------ 834
Query: 914 SAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHS 973
P P PA W+ G W CS +C G Q R + C + + +
Sbjct: 835 -----PDDRP--------PARWVAGSWGPCSASCGSGLQKRAVDCRGSAG----QRTVPA 877
Query: 974 LCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTS 1033
P + QAC P W L WS CSK+CGRG ++R L C G L QC
Sbjct: 878 CDAAHRPVETQACGEPC--PTWELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNL 935
Query: 1034 LPRPELQEGCVLGRC 1048
+P+ + CVL C
Sbjct: 936 HRKPQELDFCVLRPC 950
Score = 64.7 bits (156), Expect = 5e-10
Identities = 43/126 (34%), Positives = 56/126 (44%), Gaps = 20/126 (15%)
Query: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRA 1114
+WVA SW CSA+CG G++KR + C +G G+ T P C +P +E
Sbjct: 842 RWVAGSWGPCSASCGSGLQKRAVDC--RGSAGQR-TVP--ACDAAHRP---VETQACGEP 893
Query: 1115 CPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQG---RPSSSCLLHQKPPVLRA 1171
CP W W C+ +CG G Q RS+ CV G C LH+KP L
Sbjct: 894 CPT---------WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDF 944
Query: 1172 CNTNFC 1177
C C
Sbjct: 945 CVLRPC 950
Score = 37.0 bits (84), Expect = 0.11
Identities = 50/190 (26%), Positives = 66/190 (34%), Gaps = 28/190 (14%)
Query: 999 PWSQCSKTC-------GRGVRKRELLCKG-SAAETLPESQCTSLPRPELQEGCVLGRCPK 1050
PWS CS G G + K S E LP + T + EL G CP
Sbjct: 402 PWSACSAAIITDFLDSGHGDCLLDQPSKPISLPEDLPGASYTLSQQCELAFGVGSKPCPY 461
Query: 1051 NSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
+Q+ W C+ G K +M C + F P + + L L+ C
Sbjct: 462 ---MQYCTKLW--CT-----GKAKGQMVCQTRHF-------PWADGTSCGEGKLCLKGAC 504
Query: 1111 -NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVL 1169
R H V A W P+ C+ TCGGGVQ C +
Sbjct: 505 VERHNLNKHRVDGSWAKWD--PYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKY 562
Query: 1170 RACNTNFCPA 1179
R+CN CP+
Sbjct: 563 RSCNLEPCPS 572
Score = 34.3 bits (77), Expect = 0.75
Identities = 19/59 (32%), Positives = 27/59 (45%), Gaps = 3/59 (5%)
Query: 1125 AGWYSLPWQQCTVTCGGGVQTRSVHCVQQG--RPSSSCLLHQKPPVLRACNTNFCPAPE 1181
A W + W C+ +CG G+Q R+V C R +C +P +AC CP E
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACGEP-CPTWE 898
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 405 bits (1042), Expect = e-113
Identities = 287/882 (32%), Positives = 420/882 (47%), Gaps = 92/882 (10%)
Query: 97 LHYRFSAFGQELHLELKPS-AILSSHFIVQVLGKDGASETQKPEVQQCFYQGFIRNDSSS 155
L SAFG+ L L P + L+ F ++ LG G + + ++ CF+ G + + S
Sbjct: 53 LALHLSAFGKGFVLRLAPDDSFLAPEFKIERLGGSGRATGGERGLRGCFFSGTVNGEPES 112
Query: 156 SVAVSTCAGLSGLIRTRKNEFLISPLPQ--LLAQEHNYS--SPAGHHPHVLYKRTAEEKI 211
AVS C GLSG EF I P LAQ H PAG P R E ++
Sbjct: 113 LAAVSLCRGLSGSFLLDGEEFTIQPQGAGGSLAQPHRLQRWGPAGARP---LPRGPEWEV 169
Query: 212 QRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYL 271
+ G R G SQ E E P PP
Sbjct: 170 ETGEGQ----RQERGDHQEDSEEESQEEEAEGASE---------------PPPPL----- 205
Query: 272 RFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKD 331
G++ R +R +++ VETL+VAD M +G ++ +ILT+M++ + ++K
Sbjct: 206 -----GATSRTKRFVSEARF---VETLLVADASMAAFYG-ADLQNHILTLMSVAARIYKH 256
Query: 332 GTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSAL---IGKNGKRHDHAIL 388
+I + IN++VV ++++E E G ++ + +L +FC WQ ++ + +D AIL
Sbjct: 257 PSIKNSINLMVVKVLIVEDEKWGPEVSDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAIL 316
Query: 389 LTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDG 448
LT + C + CDTLG A I +C +SC++ ED GL A T+AHE GH M HD
Sbjct: 317 LTRQNFCGQEGL-CDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHVLSMPHD- 374
Query: 449 EGNPCRKAEG-----NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQ 503
+ PC + G ++M+P N WS CS YL + L CL+D P A
Sbjct: 375 DSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDAP--AAA 432
Query: 504 YKYPDKLPGQ--IYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR--CETK--F 557
P LPG+ +Y D QC+ FG + C +D+C LWCH G C TK
Sbjct: 433 LPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGS 492
Query: 558 MPAAEGTVCGLSMWCRQGQCVKFGELG-PRPI-HGQWSAWSKWSECSRTCGGGVKFQERH 615
+P A+GT CG C +G C+ E+ P+P+ G W+ W W ECSRTCGGGV+F R
Sbjct: 493 LPWADGTPCGPGHLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRE 552
Query: 616 CNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFR---GWFYQWKP 672
C +P+PQ GG +C G YQ C+ C + FR QQC +YN+ + G QW P
Sbjct: 553 CKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAYNYTDMDGNLLQWVP 612
Query: 673 -YTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGS 731
Y V DRCKL+C+A F KV DGT C P +C+ G C GCDH + S
Sbjct: 613 KYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDS 672
Query: 732 KAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQE-----LQVSS 786
D CGVC G ++C+ G + Y +V IPAGA +I++++ +Q
Sbjct: 673 PRKLDKCGVCGGKGNSCRKVSGSLTPTNYG--YNDIVTIPAGATNIDVKQRSHPGVQNDG 730
Query: 787 SYLAVRSLSQKYYLTGGWSID-WPGEFPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEI 845
+YLA+++ +Y L G +I + GT +Y S ERL + P E L ++
Sbjct: 731 NYLALKTADGQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQL 790
Query: 846 L-MQGK--NPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ------------SECSVSCG 890
L + G+ P + + + +P ++ + ++K A T +I+Q SECS +CG
Sbjct: 791 LTVPGEVFPPKVKYTFFVPNDVDFSMQSSKERA-TTNIIQPLLHAQWVLGDWSECSSTCG 849
Query: 891 GGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCP 932
G+ C RD + Q S+ C+ KP + K C + CP
Sbjct: 850 AGWQRRTVEC-RDPSGQA-SATCNKALKP-EDAKPCESQLCP 888
Score = 46.6 bits (109), Expect = 1e-04
Identities = 20/56 (35%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCP 1049
QW LG WS+CS TCG G ++R + C+ + + + C +PE + C CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQA--SATCNKALKPEDAKPCESQLCP 888
Score = 44.3 bits (103), Expect = 7e-04
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 1/55 (1%)
Query: 1125 AGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGRPSSSCLLHQKPPVLRACNTNFCP 1178
A W W +C+ TCG G Q R+V C G+ S++C KP + C + CP
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
Score = 43.9 bits (102), Expect = 0.001
Identities = 21/62 (33%), Positives = 30/62 (48%), Gaps = 8/62 (12%)
Query: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRA 1114
QWV WSECS+TCG G ++R ++C + Q C KP + + C +
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQA------SATCNKALKP--EDAKPCESQL 886
Query: 1115 CP 1116
CP
Sbjct: 887 CP 888
Score = 42.4 bits (98), Expect = 0.003
Identities = 29/118 (24%), Positives = 44/118 (37%), Gaps = 25/118 (21%)
Query: 889 CGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMP-GEWSTCSKAC 947
CG G++ + CL ++ + + KPV + W P G W CS+ C
Sbjct: 501 CGPGHLCSEGSCLPEEEVE--------RPKPVAD----------GGWAPWGPWGECSRTC 542
Query: 948 AGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSK 1005
GG Q +C +P L + Q+C++ CPP QC K
Sbjct: 543 GGGVQFSHRECKDPEPQNGGRYCL------GRRAKYQSCHTEECPPDGKSFREQQCEK 594
Score = 35.0 bits (79), Expect = 0.44
Identities = 49/201 (24%), Positives = 66/201 (32%), Gaps = 36/201 (17%)
Query: 999 PWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRP----------ELQEGC--VLG 1046
PWS CS + ELL G + L ++ +LP P +L + C + G
Sbjct: 404 PWSPCS-----AMYLTELL-DGGHGDCLLDAPAAALPLPTGLPGRMALYQLDQQCRQIFG 457
Query: 1047 ----RCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKP 1102
CP S A W E C K G L C
Sbjct: 458 PDFRHCPNTSAQDVCAQLWCHTDGA--------EPLCHTKN--GSLPWADGTPCG---PG 504
Query: 1103 NLDLEETCNRRACPAHPVYNMVAGWYSL-PWQQCTVTCGGGVQTRSVHCVQQGRPSSSCL 1161
+L E +C P GW PW +C+ TCGGGVQ C +
Sbjct: 505 HLCSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRY 564
Query: 1162 LHQKPPVLRACNTNFCPAPEK 1182
+ ++C+T CP K
Sbjct: 565 CLGRRAKYQSCHTEECPPDGK 585
Score = 34.7 bits (78), Expect = 0.57
Identities = 20/59 (33%), Positives = 26/59 (44%), Gaps = 9/59 (15%)
Query: 998 GPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTS---LPRPELQEGCVLGRCPKNSR 1053
GPW +CS+TCG GV+ CK PE Q L R + C CP + +
Sbjct: 533 GPWGECSRTCGGGVQFSHRECKD------PEPQNGGRYCLGRRAKYQSCHTEECPPDGK 585
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 402 bits (1033), Expect = e-111
Identities = 288/980 (29%), Positives = 423/980 (43%), Gaps = 119/980 (12%)
Query: 281 RPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINV 340
R RR+AG L++E LV + + H + + Y+LT +N+ + L +D ++G+ V
Sbjct: 71 RQRRAAGGI---LHLELLVAVGPDVFQAHQE-DTERYVLTNLNIGAELLRDPSLGAQFRV 126
Query: 341 VVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHA---ILLTGFDICSW 397
+V +++L + G I + SL S C W + ++ HA + +T FD+
Sbjct: 127 HLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDL-EL 185
Query: 398 KNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAE 457
+ G + G CS SC I EDTG L TIAHE GH+FG+ HDG
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 458 GNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPK-QAGQYKY-PDKLPGQIY 515
G++M+ +WS CSR+ L LS +A C+ D P+ Q G + PD PG Y
Sbjct: 246 GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYY 305
Query: 516 DADTQCKWQFGAKAKLCSLGFVK-DICKSLWCHR---VGHRCETKFMPAAEGTVCGLSMW 571
A+ QC+ FG KA C+ D+C++L CH C +P +GT CG+ W
Sbjct: 306 SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKW 365
Query: 572 CRQGQCVKFGELGP-RPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPG 630
C +G+C EL P +HG+WS+W S CSR+CGGGV + R CNNP+P +GG C G
Sbjct: 366 CSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 425
Query: 631 SSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFR-----GWFYQWKPYTKVEEEDR-CKL 684
+ ++CN C + L+F +QQCA + +P R FY W + D C+
Sbjct: 426 ADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRH 485
Query: 685 YCKAENFEFFFAMSGKVKDGTPCSPN--KND----VCIDGVCELVGCDHELGSKAVSDAC 738
C+A F DGT C P+ + D +C+ G C GCD + S+ V D C
Sbjct: 486 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 545
Query: 739 GVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKY 798
VC GDNSTC KG + +A EY + + S+ I + ++LAVR + +Y
Sbjct: 546 QVCGGDNSTCSPRKGSF-TAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IGGRY 603
Query: 799 YLTGGWSIDWPGEFP--FAGTTFEYQRSFN-----RPERLYAPGPTNETLVFEILMQG-- 849
+ G SI +P EY+ + R E + GP E ++ +
Sbjct: 604 VVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGE 663
Query: 850 -----KNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQ 904
P I + Y PK R A+ W+ V+ CSVSCG G V CL
Sbjct: 664 EYGNLTRPDITFTYFQPK---------PRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQA 714
Query: 905 NTQ-VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKP 963
+ V + C +P P+ C CP YW G++ CS +C GG + R ++CV
Sbjct: 715 RKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCV---- 770
Query: 964 FQKEEAVLHSLCPV-------STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKREL 1016
+ + ++L +L P ++ CN CP +W + S C+ G G+
Sbjct: 771 -EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENE 829
Query: 1017 LCKGSA------AETLPESQCTSLPRPELQEGCVLGRCP-------KNSRLQWVASSW-- 1061
C A P S LP P E CV CP S + S W
Sbjct: 830 TCVPGADGLEAPVTEGPGSVDEKLPAP---EPCVGMSCPPGWGHLDATSAGEKAPSPWGS 886
Query: 1062 ---------------SECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDL 1106
CS +CG G+ + C + + + E C KP
Sbjct: 887 IRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALR---VPVQEELCGLASKPG-SR 942
Query: 1107 EETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV--------QQGRPSS 1158
E C CPA Y + A C+V+CG GV R ++C ++ +
Sbjct: 943 REVCQAVPCPARWQYKLAA---------CSVSCGRGVVRRILYCARAHGEDDGEEILLDT 993
Query: 1159 SCLLHQKPPVLRACNTNFCP 1178
C +P AC+ CP
Sbjct: 994 QCQGLPRPEPQEACSLEPCP 1013
Score = 112 bits (280), Expect = 2e-24
Identities = 78/257 (30%), Positives = 115/257 (44%), Gaps = 37/257 (14%)
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQ---KKPFQKEEAVLHSLCPVSTP--TQVQACNSH 989
W P S CS +C G + C+ + P Q+E LC +++ ++ + C +
Sbjct: 897 WTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEE------LCGLASKPGSRREVCQAV 949
Query: 990 ACPPQWSLGPWSQCSKTCGRGVRKRELLC-----KGSAAETLPESQCTSLPRPELQEGCV 1044
CP +W + CS +CGRGV +R L C + E L ++QC LPRPE QE C
Sbjct: 950 PCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACS 1008
Query: 1045 LGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNL 1104
L CP +W S CSA+CGLG +R + C + QG+ + E C + +P
Sbjct: 1009 LEPCPP----RWKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVEVDEAACAALVRPEA 1063
Query: 1105 DLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV----QQGRPSSSC 1160
+ C C W+ W +C+V+CG G+Q R C+ Q P+ C
Sbjct: 1064 SV--PCLIADCTYR--------WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFC 1113
Query: 1161 LLHQKPPVLRACNTNFC 1177
KP +R C C
Sbjct: 1114 QHLPKPVTVRGCWAGPC 1130
Score = 87.8 bits (216), Expect = 6e-17
Identities = 51/177 (28%), Positives = 73/177 (41%), Gaps = 7/177 (3%)
Query: 878 WSIVQSECSVSCGGGYINVKAICLR-----DQNTQVNSSFCSAKTKPVTEPKICNAFSCP 932
W + CSVSCG G + C R D + + C +P + + C+ CP
Sbjct: 955 WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCP 1013
Query: 933 AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
W CS +C G R + CVQ Q E + + P C C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT 1073
Query: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAET-LPESQCTSLPRPELQEGCVLGRC 1048
+W +G W +CS +CG G+++R C G A+ +P C LP+P GC G C
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 21/144 (14%)
Query: 1053 RLQWV-ASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCN 1111
R WV A+ CS +CG G+R C ++ + + T +C+ ++P E C
Sbjct: 683 RQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETV---QCQGSQQPPA-WPEACV 738
Query: 1112 RRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGR-----PSSSCLLHQK 1165
CP + W + C+ +CGGG++ R V CV+ QG P + C +
Sbjct: 739 LEPCPPY--------WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ 790
Query: 1166 PPV--LRACNTNFCPAPEKREDPS 1187
P L CN CPA + +PS
Sbjct: 791 QPAVALETCNPQPCPARWEVSEPS 814
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 402 bits (1033), Expect = e-111
Identities = 288/980 (29%), Positives = 423/980 (43%), Gaps = 119/980 (12%)
Query: 281 RPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINV 340
R RR+AG L++E LV + + H + + Y+LT +N+ + L +D ++G+ V
Sbjct: 71 RQRRAAGGI---LHLELLVAVGPDVFQAHQE-DTERYVLTNLNIGAELLRDPSLGAQFRV 126
Query: 341 VVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHA---ILLTGFDICSW 397
+V +++L + G I + SL S C W + ++ HA + +T FD+
Sbjct: 127 HLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDL-EL 185
Query: 398 KNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAE 457
+ G + G CS SC I EDTG L TIAHE GH+FG+ HDG
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 458 GNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPK-QAGQYKY-PDKLPGQIY 515
G++M+ +WS CSR+ L LS +A C+ D P+ Q G + PD PG Y
Sbjct: 246 GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYY 305
Query: 516 DADTQCKWQFGAKAKLCSLGFVK-DICKSLWCHR---VGHRCETKFMPAAEGTVCGLSMW 571
A+ QC+ FG KA C+ D+C++L CH C +P +GT CG+ W
Sbjct: 306 SANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKW 365
Query: 572 CRQGQCVKFGELGP-RPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPG 630
C +G+C EL P +HG+WS+W S CSR+CGGGV + R CNNP+P +GG C G
Sbjct: 366 CSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVG 425
Query: 631 SSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFR-----GWFYQWKPYTKVEEEDR-CKL 684
+ ++CN C + L+F +QQCA + +P R FY W + D C+
Sbjct: 426 ADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRH 485
Query: 685 YCKAENFEFFFAMSGKVKDGTPCSPN--KND----VCIDGVCELVGCDHELGSKAVSDAC 738
C+A F DGT C P+ + D +C+ G C GCD + S+ V D C
Sbjct: 486 MCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRC 545
Query: 739 GVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKY 798
VC GDNSTC KG + +A EY + + S+ I + ++LAVR + +Y
Sbjct: 546 QVCGGDNSTCSPRKGSF-TAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IGGRY 603
Query: 799 YLTGGWSIDWPGEFP--FAGTTFEYQRSFN-----RPERLYAPGPTNETLVFEILMQG-- 849
+ G SI +P EY+ + R E + GP E ++ +
Sbjct: 604 VVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGE 663
Query: 850 -----KNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQ 904
P I + Y PK R A+ W+ V+ CSVSCG G V CL
Sbjct: 664 EYGNLTRPDITFTYFQPK---------PRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQA 714
Query: 905 NTQ-VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKP 963
+ V + C +P P+ C CP YW G++ CS +C GG + R ++CV
Sbjct: 715 RKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCV---- 770
Query: 964 FQKEEAVLHSLCPV-------STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKREL 1016
+ + ++L +L P ++ CN CP +W + S C+ G G+
Sbjct: 771 -EAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENE 829
Query: 1017 LCKGSA------AETLPESQCTSLPRPELQEGCVLGRCP-------KNSRLQWVASSW-- 1061
C A P S LP P E CV CP S + S W
Sbjct: 830 TCVPGADGLEAPVTEGPGSVDEKLPAP---EPCVGMSCPPGWGHLDATSAGEKAPSPWGS 886
Query: 1062 ---------------SECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDL 1106
CS +CG G+ + C + + + E C KP
Sbjct: 887 IRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALR---VPVQEELCGLASKPG-SR 942
Query: 1107 EETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV--------QQGRPSS 1158
E C CPA Y + A C+V+CG GV R ++C ++ +
Sbjct: 943 REVCQAVPCPARWQYKLAA---------CSVSCGRGVVRRILYCARAHGEDDGEEILLDT 993
Query: 1159 SCLLHQKPPVLRACNTNFCP 1178
C +P AC+ CP
Sbjct: 994 QCQGLPRPEPQEACSLEPCP 1013
Score = 112 bits (280), Expect = 2e-24
Identities = 78/257 (30%), Positives = 115/257 (44%), Gaps = 37/257 (14%)
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQ---KKPFQKEEAVLHSLCPVSTP--TQVQACNSH 989
W P S CS +C G + C+ + P Q+E LC +++ ++ + C +
Sbjct: 897 WTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEE------LCGLASKPGSRREVCQAV 949
Query: 990 ACPPQWSLGPWSQCSKTCGRGVRKRELLC-----KGSAAETLPESQCTSLPRPELQEGCV 1044
CP +W + CS +CGRGV +R L C + E L ++QC LPRPE QE C
Sbjct: 950 PCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACS 1008
Query: 1045 LGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNL 1104
L CP +W S CSA+CGLG +R + C + QG+ + E C + +P
Sbjct: 1009 LEPCPP----RWKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVEVDEAACAALVRPEA 1063
Query: 1105 DLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV----QQGRPSSSC 1160
+ C C W+ W +C+V+CG G+Q R C+ Q P+ C
Sbjct: 1064 SV--PCLIADCTYR--------WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFC 1113
Query: 1161 LLHQKPPVLRACNTNFC 1177
KP +R C C
Sbjct: 1114 QHLPKPVTVRGCWAGPC 1130
Score = 87.8 bits (216), Expect = 6e-17
Identities = 51/177 (28%), Positives = 73/177 (41%), Gaps = 7/177 (3%)
Query: 878 WSIVQSECSVSCGGGYINVKAICLR-----DQNTQVNSSFCSAKTKPVTEPKICNAFSCP 932
W + CSVSCG G + C R D + + C +P + + C+ CP
Sbjct: 955 WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCP 1013
Query: 933 AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
W CS +C G R + CVQ Q E + + P C C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT 1073
Query: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAET-LPESQCTSLPRPELQEGCVLGRC 1048
+W +G W +CS +CG G+++R C G A+ +P C LP+P GC G C
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 21/144 (14%)
Query: 1053 RLQWV-ASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCN 1111
R WV A+ CS +CG G+R C ++ + + T +C+ ++P E C
Sbjct: 683 RQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETV---QCQGSQQPPA-WPEACV 738
Query: 1112 RRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGR-----PSSSCLLHQK 1165
CP + W + C+ +CGGG++ R V CV+ QG P + C +
Sbjct: 739 LEPCPPY--------WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ 790
Query: 1166 PPV--LRACNTNFCPAPEKREDPS 1187
P L CN CPA + +PS
Sbjct: 791 QPAVALETCNPQPCPARWEVSEPS 814
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 374 bits (960), Expect = e-103
Identities = 278/978 (28%), Positives = 408/978 (41%), Gaps = 146/978 (14%)
Query: 281 RPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINV 340
R RR+AG L++E LV + + H + + Y+LT +N+ + L +D ++G+ V
Sbjct: 71 RQRRAAGGI---LHLELLVAVGPDVFQAHQE-DTERYVLTNLNIGAELLRDPSLGAQFRV 126
Query: 341 VVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDHAIL---LTGFDICSW 397
+V +++L + G I + SL S C W + ++ HA L +T FD+
Sbjct: 127 HLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDL-EL 185
Query: 398 KNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRKAE 457
+ G + G CS SC I EDTG L TIAHE GH+FG+ HDG
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 458 GNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDA 517
G++M+ +WS CSR+ L LS A
Sbjct: 246 GHVMASDGAAPRAGLAWSPCSRRQLLSLLS-----------------------------A 276
Query: 518 DTQCKWQFGAKAKLCSLGFVK-DICKSLWCHRVG---HRCETKFMPAAEGTVCGLSMWCR 573
+ QC+ FG KA C+ D+C++L CH C +P +GT CG+ WC
Sbjct: 277 NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCS 336
Query: 574 QGQCVKFGELGP-RPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSS 632
+G+C EL P +HG+WS+W S CSR+CGGGV + R CNNP+P +GG C G+
Sbjct: 337 KGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGAD 396
Query: 633 RIYQLCNINPCNENSLDFRAQQCAEYNSKPFR-----GWFYQWKPYTKVEEEDR-CKLYC 686
++CN C + L+F +QQCA + +P R FY W + D C+ C
Sbjct: 397 LQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDALCRHMC 456
Query: 687 KAENFEFFFAMSGKVKDGTPCSPN--KND----VCIDGVCELVGCDHELGSKAVSDACGV 740
+A F DGT C P+ + D +C+ G C GCD + S+ V D C V
Sbjct: 457 RAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQV 516
Query: 741 CKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYL 800
C GDNSTC KG + +A EY + + S+ I + ++LAVR + +Y +
Sbjct: 517 CGGDNSTCSPRKGSF-TAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR-IGGRYVV 574
Query: 801 TGGWSIDWPGEFP--FAGTTFEYQRSFN-----RPERLYAPGPTNETLVFEILMQG---- 849
G SI +P EY+ + R E + GP E ++ +
Sbjct: 575 AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEY 634
Query: 850 ---KNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNT 906
P I + Y PK R A+ W+ V+ CSVSCG G V CL
Sbjct: 635 GNLTRPDITFTYFQPK---------PRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARK 685
Query: 907 Q-VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQ 965
+ V + C +P P+ C CP YW G++ CS +C GG + R ++CV +
Sbjct: 686 ELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCV-----E 740
Query: 966 KEEAVLHSLCPV-------STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLC 1018
+ ++L +L P ++ CN CP +W + S C+ G G+ C
Sbjct: 741 AQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETC 800
Query: 1019 KGSA------AETLPESQCTSLPRPELQEGCVLGRCP-------KNSRLQWVASSW---- 1061
A P S LP P E CV CP S + S W
Sbjct: 801 VPGADGLEAPVTEGPGSVDEKLPAP---EPCVGMSCPPGWGHLDATSAGEKAPSPWGSIR 857
Query: 1062 -------------SECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEE 1108
CS +CG G+ + C + + + E C KP E
Sbjct: 858 TGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALR---VPVQEELCGLASKPG-SRRE 913
Query: 1109 TCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV--------QQGRPSSSC 1160
C CPA Y + A C+V+CG GV R ++C ++ + C
Sbjct: 914 VCQAVPCPARWQYKLAA---------CSVSCGRGVVRRILYCARAHGEDDGEEILLDTQC 964
Query: 1161 LLHQKPPVLRACNTNFCP 1178
+P AC+ CP
Sbjct: 965 QGLPRPEPQEACSLEPCP 982
Score = 112 bits (280), Expect = 2e-24
Identities = 78/257 (30%), Positives = 115/257 (44%), Gaps = 37/257 (14%)
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQ---KKPFQKEEAVLHSLCPVSTP--TQVQACNSH 989
W P S CS +C G + C+ + P Q+E LC +++ ++ + C +
Sbjct: 866 WTPAAGS-CSVSCGRGLMELRFLCMDSALRVPVQEE------LCGLASKPGSRREVCQAV 918
Query: 990 ACPPQWSLGPWSQCSKTCGRGVRKRELLC-----KGSAAETLPESQCTSLPRPELQEGCV 1044
CP +W + CS +CGRGV +R L C + E L ++QC LPRPE QE C
Sbjct: 919 PCPARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACS 977
Query: 1045 LGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNL 1104
L CP +W S CSA+CGLG +R + C + QG+ + E C + +P
Sbjct: 978 LEPCPP----RWKVMSLGPCSASCGLGTARRSVACVQLD-QGQDVEVDEAACAALVRPEA 1032
Query: 1105 DLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV----QQGRPSSSC 1160
+ C C W+ W +C+V+CG G+Q R C+ Q P+ C
Sbjct: 1033 SV--PCLIADCTYR--------WHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFC 1082
Query: 1161 LLHQKPPVLRACNTNFC 1177
KP +R C C
Sbjct: 1083 QHLPKPVTVRGCWAGPC 1099
Score = 87.8 bits (216), Expect = 6e-17
Identities = 51/177 (28%), Positives = 73/177 (41%), Gaps = 7/177 (3%)
Query: 878 WSIVQSECSVSCGGGYINVKAICLR-----DQNTQVNSSFCSAKTKPVTEPKICNAFSCP 932
W + CSVSCG G + C R D + + C +P + + C+ CP
Sbjct: 924 WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ-EACSLEPCP 982
Query: 933 AYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
W CS +C G R + CVQ Q E + + P C C
Sbjct: 983 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT 1042
Query: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAET-LPESQCTSLPRPELQEGCVLGRC 1048
+W +G W +CS +CG G+++R C G A+ +P C LP+P GC G C
Sbjct: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 51.6 bits (122), Expect = 5e-06
Identities = 41/144 (28%), Positives = 63/144 (43%), Gaps = 21/144 (14%)
Query: 1053 RLQWV-ASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCN 1111
R WV A+ CS +CG G+R C ++ + + T +C+ ++P E C
Sbjct: 652 RQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETV---QCQGSQQPPA-WPEACV 707
Query: 1112 RRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ-QGR-----PSSSCLLHQK 1165
CP + W + C+ +CGGG++ R V CV+ QG P + C +
Sbjct: 708 LEPCPPY--------WAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ 759
Query: 1166 PPV--LRACNTNFCPAPEKREDPS 1187
P L CN CPA + +PS
Sbjct: 760 QPAVALETCNPQPCPARWEVSEPS 783
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 372 bits (954), Expect = e-102
Identities = 264/882 (29%), Positives = 385/882 (43%), Gaps = 114/882 (12%)
Query: 143 CFYQGFIRNDSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPHVL 202
CFY+G + S C GL G + + + PL + E G +
Sbjct: 130 CFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGPWAEEEKGRVYGDGSARI 189
Query: 203 YKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKYAP 262
E P + P +P HA H + + +
Sbjct: 190 LHVYTREGFSFEALPPRASCETPASTPEAHEHAPA------HSNPSGRAALASQLLDQSA 243
Query: 263 KPPTEDTYLRFDEYGSSG------RPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTT 316
P G SG R RRS ++++ VE L+VAD M +G+G +
Sbjct: 244 LSPA----------GGSGPQTWWRRRRRSISRARQ---VELLLVADASMARLYGRG-LQH 289
Query: 317 YILTVMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQ---S 373
Y+LT+ ++ + L+ +I + I + VV +++L + L ++ +A +L +FC+WQ +
Sbjct: 290 YLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHN 349
Query: 374 ALIGKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFT 433
L + + +D AIL T D+C + CDTLG A + +CS RSC + ED GL AFT
Sbjct: 350 QLGDDHEEHYDAAILFTREDLCG--HHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFT 407
Query: 434 IAHESGHNFGMIHDGEGNPCRKAEGN-----IMSPTLTGNNGVFSWSSCSRQYLKKFLST 488
+AHE GH G+ HD + C + G+ +MS LT + WS C+ + +FL
Sbjct: 408 VAHEIGHLLGLSHD-DSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDD 466
Query: 489 PQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHR 548
CL+D P++ Q P++LPGQ YDA QC FG + +C D+C LWC
Sbjct: 467 GHGNCLLDLPRK--QILGPEELPGQTYDATQQCNLTFGPEYSVCP---GMDVCARLWCAV 521
Query: 549 VGHR---CETKFMPAAEGTVCGLSMWCRQGQCV--KFGELGPRPIHGQWSAWSKWSECSR 603
V C TK +PA EGT CG C QG+CV + HG W +W W +CSR
Sbjct: 522 VRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSR 581
Query: 604 TCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYN--SK 661
+CGGGV+F RHCNNP P+ G +C G IY+ C++ PC N FR +QC N
Sbjct: 582 SCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQS 641
Query: 662 PFRG--WFYQWKP-YTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDG 718
+G F +W P Y V D CKL C+A+ ++ S KV DGT C N VC+ G
Sbjct: 642 DAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSNSVCVRG 701
Query: 719 VCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIE 778
C GCD +GSK D CGVC GDNS+C G + K+ Y VV IP GA I+
Sbjct: 702 KCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTF--NKKSKGYTDVVRIPEGATHIK 759
Query: 779 IQELQVS-----SSYLAVRSLSQKYYLTGGWSIDWPGE-FPFAGTTFEYQRSFNRPERLY 832
+++ + ++YLA++ + +Y + G + I GT Y +R + L+
Sbjct: 760 VRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLH 819
Query: 833 APG--PTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQSECSVSCG 890
G T E L+ +IL + +Y+ TP
Sbjct: 820 GMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTP---------------------- 857
Query: 891 GGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGG 950
+VNS K + + W+ G W CS+ C G
Sbjct: 858 ----------------KVNSVTSHGSNK-------VGSHTSQPQWVTGPWLACSRTCDTG 894
Query: 951 QQSRKIQCVQKKPFQKEEAVLHSLCPVS-TPTQVQACNSHAC 991
+R +QC Q L CP+S P+ + C C
Sbjct: 895 WHTRTVQC------QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 45.4 bits (106), Expect = 3e-04
Identities = 21/61 (34%), Positives = 28/61 (45%), Gaps = 2/61 (3%)
Query: 988 SHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGR 1047
SH PQW GPW CS+TC G R + C+ + C RP + C+L +
Sbjct: 872 SHTSQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKL--AKGCPLSQRPSAFKQCLLKK 929
Query: 1048 C 1048
C
Sbjct: 930 C 930
Score = 44.7 bits (104), Expect = 6e-04
Identities = 36/135 (26%), Positives = 53/135 (39%), Gaps = 12/135 (8%)
Query: 926 CNAFSCPAYWMPGEWSTCSKA-CAGGQQ------SRKIQCVQKKPFQKEEAVLHSLCPVS 978
CN P Y + C++ CA +Q ++K+ V+ P K L C
Sbjct: 497 CNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDK 556
Query: 979 TPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPE 1038
T + + +SH W G W QCS++CG GV+ C A CT +
Sbjct: 557 TKKKYYSTSSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRN-NGRYCTG--KRA 611
Query: 1039 LQEGCVLGRCPKNSR 1053
+ C L CP N +
Sbjct: 612 IYRSCSLMPCPPNGK 626
Score = 39.3 bits (90), Expect = 0.023
Identities = 18/52 (34%), Positives = 24/52 (46%), Gaps = 1/52 (1%)
Query: 1127 WYSLPWQQCTVTCGGGVQTRSVHCVQQGRP-SSSCLLHQKPPVLRACNTNFC 1177
W + PW C+ TC G TR+V C R + C L Q+P + C C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 35.8 bits (81), Expect = 0.26
Identities = 16/47 (34%), Positives = 23/47 (48%)
Query: 1132 WQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
W QC+ +CGGGVQ HC ++ K + R+C+ CP
Sbjct: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCP 622
Score = 34.3 bits (77), Expect = 0.75
Identities = 42/188 (22%), Positives = 76/188 (40%), Gaps = 30/188 (15%)
Query: 909 NSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACA-----GGQQSRKIQCVQKKP 963
+S FC +T TE K + + WS C+ A G + + +K+
Sbjct: 422 DSKFCE-ETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI 480
Query: 964 FQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQ-CSKTCGRGVRKRELLCKGSA 1022
EE P T Q CN P++S+ P C++ VR+ +++C
Sbjct: 481 LGPEEL------PGQTYDATQQCNL-TFGPEYSVCPGMDVCARLWCAVVRQGQMVC---L 530
Query: 1023 AETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASS----------WSECSATCGLGV 1072
+ LP + T + + C+ G+C ++ ++ ++S W +CS +CG GV
Sbjct: 531 TKKLPAVEGTPCGKGRI---CLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGV 587
Query: 1073 RKREMKCS 1080
+ C+
Sbjct: 588 QFAYRHCN 595
Score = 32.3 bits (72), Expect = 2.8
Identities = 12/30 (40%), Positives = 16/30 (53%)
Query: 1052 SRLQWVASSWSECSATCGLGVRKREMKCSE 1081
S+ QWV W CS TC G R ++C +
Sbjct: 875 SQPQWVTGPWLACSRTCDTGWHTRTVQCQD 904
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 361 bits (926), Expect = 3e-99
Identities = 228/621 (36%), Positives = 312/621 (50%), Gaps = 39/621 (6%)
Query: 279 SGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDI 338
S RPRR+ + VETLVVAD KM HG G + Y+LTVM + FK +I + +
Sbjct: 204 SPRPRRAKRFASLSRFVETLVVADDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPV 262
Query: 339 NVVVVSLILLEQEPGGLLINHHADQSLNSFCQWQSALIGKNGKRHDH---AILLTGFDIC 395
++VV L++L G + A Q+L SFC WQ L DH AIL T D+C
Sbjct: 263 SLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLC 322
Query: 396 SWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNPCRK 455
CDTLG A + +C RSC I ED GL AFT AHE GH F M+HD PC
Sbjct: 323 GVST--CDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNMLHDNS-KPCIS 379
Query: 456 AEG------NIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDK 509
G ++M+P + + WS CS +++ FL CL+D+P+ P
Sbjct: 380 LNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLDKPE--APLHLPVT 437
Query: 510 LPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWC--HRVGHR-CETKFMPAAEGTVC 566
PG+ YDAD QC+ FG ++ C + C +LWC H GH C+TK P A+GT C
Sbjct: 438 FPGKDYDADRQCQLTFGPDSRHCPQ--LPPPCAALWCSGHLNGHAMCQTKHSPWADGTPC 495
Query: 567 GLSMWCRQGQCVKFGELGPR--PIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYG 624
G + C G+C+ +L P G W W W +CSRTCGGGV+F R C P P+ G
Sbjct: 496 GPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNG 555
Query: 625 GLFCPGSSRIYQLCNINPCNENS-LDFRAQQCAEYNS-----KPFRGWFYQWKP-YTKVE 677
G +C G ++ CN C S L FR +QCA YN K F G W P YT V
Sbjct: 556 GKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDLFKSFPGPM-DWVPRYTGVA 614
Query: 678 EEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDA 737
+D+CKL C+A+ +++ + +V DGTPCSP+ + VC+ G C GCD +GSK D
Sbjct: 615 PQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRIIGSKKKFDK 674
Query: 738 CGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQEL---QVSSSYLAVRSL 794
C VC GD S C G + Y VV IPAGA I +++ S YLA++
Sbjct: 675 CMVCGGDGSGCSKQSGSFRKFRYG--YNNVVTIPAGATHILVRQQGNPGHRSIYLALKLP 732
Query: 795 SQKYYLTGGWSI-DWPGEFPFAG-TTFEYQRSFNRPERLYAPGPTNETLVFEILMQG--K 850
Y L G +++ P + G + Y + E L GP + L ++L+ G +
Sbjct: 733 DGSYALNGEYTLMPSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQ 792
Query: 851 NPGIAWKYALPKVMNGTPPAT 871
+ + + + +P+ TP T
Sbjct: 793 DTRLRYSFFVPRPTPSTPRPT 813
Score = 40.0 bits (92), Expect = 0.014
Identities = 18/48 (37%), Positives = 23/48 (47%)
Query: 1131 PWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLRACNTNFCP 1178
PW C+ TCGGGVQ S C + + + R+CNT CP
Sbjct: 528 PWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCP 575
Score = 32.3 bits (72), Expect = 2.8
Identities = 18/59 (30%), Positives = 25/59 (42%), Gaps = 7/59 (11%)
Query: 935 WMP-GEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
W P G W CS+ C GG Q C + P + C T+ ++CN+ CP
Sbjct: 523 WGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGK-----YCE-GRRTRFRSCNTEDCP 575
Score = 30.8 bits (68), Expect = 8.2
Identities = 10/15 (66%), Positives = 12/15 (80%)
Query: 998 GPWSQCSKTCGRGVR 1012
GPW CS+TCG GV+
Sbjct: 527 GPWGDCSRTCGGGVQ 541
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 342 bits (876), Expect = 2e-93
Identities = 190/532 (35%), Positives = 263/532 (49%), Gaps = 57/532 (10%)
Query: 592 WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFR 651
W WS+WS CSRTCGGGV F+ER C + + GG C G +R ++ C C + + DFR
Sbjct: 29 WGPWSQWSPCSRTCGGGVSFRERPCYSQRRD-GGSSCVGPARSHRSCRTESCPDGARDFR 87
Query: 652 AQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSPNK 711
A+QCAE++ F+G Y+W PY ++C+L C + F++ V DGTPC P K
Sbjct: 88 AEQCAEFDGAEFQGRRYRWLPYYSAP--NKCELNCIPKGENFYYKHREAVVDGTPCEPGK 145
Query: 712 NDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIP 771
DVC+DG C +VGCDHEL S D C C GD +TC YPV
Sbjct: 146 RDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTC----------------YPV---- 185
Query: 772 AGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN---RP 828
A + + +L AV+++ +YYL G W+I+ P A T Y+R P
Sbjct: 186 --AGTFDANDLS-----RAVKNVRGEYYLNGHWTIEAARALPAASTILHYERGAEGDLAP 238
Query: 829 ERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SECSV 887
ERL+A GPT+E LV E++ Q NPG+ ++Y LP P ++WS S+CS
Sbjct: 239 ERLHARGPTSEPLVIELISQEPNPGVHYEYHLPL-------RRPSPGFSWSHGSWSDCSA 291
Query: 888 SCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAY--WMPGEWSTCSK 945
CGGG+ + C D + C + +P + + CN CP W G W+ CS
Sbjct: 292 ECGGGHQSRLVFCTIDHEAYPDH-MCQRQPRPA-DRRSCNLHPCPETKRWKAGPWAPCSA 349
Query: 946 ACAGGQQSRKIQCVQKKPFQKEEAVLHSLCP--VSTPTQVQACNSHACPPQWSLGPWSQC 1003
+C GG QSR + C+ +EAV + C P +QACN C WS PW +C
Sbjct: 350 SCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA-WSPEPWGEC 408
Query: 1004 SKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSE 1063
S +CG GVRKR + C+G L + C+ RP L E CV CP S W +W
Sbjct: 409 SVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSDQAWHVGTWGL 468
Query: 1064 CSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRAC 1115
CS +C G R+R++ C+ P C +++ E CN + C
Sbjct: 469 CSKSCSSGTRRRQVICA---------IGPPSHCGSLQHSKPVDVEPCNTQPC 511
Score = 138 bits (347), Expect = 4e-32
Identities = 92/279 (32%), Positives = 119/279 (42%), Gaps = 35/279 (12%)
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST-PTQVQACNSHACPP 993
W G WS CS C GG QSR + C EA +C P ++CN H CP
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTID-----HEAYPDHMCQRQPRPADRRSCNLHPCPE 335
Query: 994 --QWSLGPWSQCSKTCGRGVRKRELLCKGSAA----ETLPESQCTSLP-RPELQEGCVLG 1046
+W GPW+ CS +CG G + R + C S E + E++C LP +P + C L
Sbjct: 336 TKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQ 395
Query: 1047 RCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDL 1106
RC W W ECS +CG+GVRKR + C +G +G L+ C +P L
Sbjct: 396 RCAA-----WSPEPWGECSVSCGVGVRKRSVTC--RGERGSLLH--TAACSLEDRP--PL 444
Query: 1107 EETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKP 1166
E C CP W+ W C+ +C G + R V C L H KP
Sbjct: 445 TEPCVHEDCPLLSDQ----AWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKP 500
Query: 1167 PVLRACNTNFCPAPEKREDPSCVDFFN-----WCHLVPQ 1200
+ CNT C P+ E PS D W L PQ
Sbjct: 501 VDVEPCNTQPCHLPQ--EVPSMQDVHTPASNPWMPLGPQ 537
Score = 78.2 bits (191), Expect = 4e-14
Identities = 51/172 (29%), Positives = 76/172 (44%), Gaps = 21/172 (12%)
Query: 1016 LLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKR 1075
L +G +E L + P P + L + W SWS+CSA CG G + R
Sbjct: 241 LHARGPTSEPLVIELISQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSR 300
Query: 1076 EMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQC 1135
+ C+ +P+ C+ +P +RR+C HP W + PW C
Sbjct: 301 LVFCTIDHE-----AYPDHMCQRQPRP-------ADRRSCNLHPCPE-TKRWKAGPWAPC 347
Query: 1136 TVTCGGGVQTRSVHC-------VQQGRPSSSCL-LHQKPPVLRACNTNFCPA 1179
+ +CGGG Q+RSV+C +Q+ + C L KPP ++ACN C A
Sbjct: 348 SASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
Score = 37.4 bits (85), Expect = 0.088
Identities = 20/48 (41%), Positives = 24/48 (50%), Gaps = 3/48 (6%)
Query: 1132 WQQCTVTCGGGVQTRSVHCVQQGRP-SSSCLLHQKPPVLRACNTNFCP 1178
W C+ TCGGGV R C Q R SSC+ + R+C T CP
Sbjct: 35 WSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPARSH--RSCRTESCP 80
Score = 35.8 bits (81), Expect = 0.26
Identities = 23/63 (36%), Positives = 29/63 (46%), Gaps = 4/63 (6%)
Query: 586 RPIHG-QWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSR--IYQLCNINP 642
RP G WS S WS+CS CGGG + + C Y C R + CN++P
Sbjct: 274 RPSPGFSWSHGS-WSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHP 332
Query: 643 CNE 645
C E
Sbjct: 333 CPE 335
Score = 31.6 bits (70), Expect = 4.8
Identities = 18/47 (38%), Positives = 25/47 (53%), Gaps = 5/47 (10%)
Query: 1178 PAPEKR-EDPS--CVDFFNW--CHLVPQHGVCNHKFYGKQCCKSCTR 1219
PAP + DP CVD C L+ Q +C +++Y CC SC+R
Sbjct: 1195 PAPTAQPRDPGRDCVDQPELANCDLILQAQLCGNEYYSSFCCASCSR 1241
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 339 bits (870), Expect = 8e-93
Identities = 210/713 (29%), Positives = 309/713 (43%), Gaps = 137/713 (19%)
Query: 628 CPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCK 687
C G S + C+ PC D RA QCA +NS+ F G YQW+P+T+V+ RC+L C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 688 AENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNST 747
F F+ + KV+DGT C P D+C+ G C GCD LGS D CGVC GD+ST
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 748 CKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSID 807
C+ G ++ Y ++ IPAGA ++I +L+ SS+YLA+R + + G W++D
Sbjct: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
Query: 808 WPGEFPFAGTTFEYQ---RSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYAL---- 860
PG + GT F Y R + E L A GPT + + ++ Q +NPG+ ++Y +
Sbjct: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPP 603
Query: 861 ----------------PKVMNGTPPATKRP------------------------------ 874
P+++ PP P
Sbjct: 604 PILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGS 663
Query: 875 --AYTWSIVQSECSVSCGGGYINVKAICL-RDQNTQVNSSFCSAKTKPVTEPKICNAFSC 931
AY + S CS SCG G +C+ R+ +++ C+A +P P+ C+ C
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
Query: 932 PAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHAC 991
P YW GEW++CS++C G Q R++QC Q+ + P Q+C C
Sbjct: 724 PPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
Query: 992 PPQWSLG-PWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTS-LPRPELQEGCVLGRCP 1049
W +G PWSQCS CGRG R R++ C G+ + + E +C S P+P +E C +G C
Sbjct: 784 -GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC- 841
Query: 1050 KNSRLQWVASSW-SECSATCGLGVRKREMKCSEKGF-----QGKLITFPERRCRNIKKPN 1103
W S W S+CSA CG G+++R + C G QG+ + C +P
Sbjct: 842 ---TTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPP 898
Query: 1104 LDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ------GRPS 1157
+ RAC P WY+ PW +C+ CG G Q R + CV +
Sbjct: 899 -------DMRACSLGPC-ERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSP 950
Query: 1158 SSCLLHQKPPVLRACNTNFC---------------------------------------- 1177
S+C +PP L+ C C
Sbjct: 951 SNCSHLPRPPALQPCQGQACQDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPP 1010
Query: 1178 -------------PAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSC 1217
P ++ +D C D C LV Q +C + +Y CC+SC
Sbjct: 1011 QLRPSRKRPCNSQPCSQRPDD-QCKDSSPHCPLVVQARLCVYPYYTATCCRSC 1062
Score = 38.5 bits (88), Expect = 0.040
Identities = 14/33 (42%), Positives = 19/33 (57%)
Query: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ 622
G W W +W+ CS+ CG GV+ + R C P Q
Sbjct: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
Score = 35.0 bits (79), Expect = 0.44
Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 24/89 (26%)
Query: 585 PRPIHGQ-----WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSS------- 632
P P HG W A +W+ CSR+CG G + ++ C + ++GG GSS
Sbjct: 715 PEPCHGTPCPPYWEA-GEWTSCSRSCGPGTQHRQLQC---RQEFGG---GGSSVPPERCG 767
Query: 633 -----RIYQLCNINPCNENSLDFRAQQCA 656
I Q C + C + QC+
Sbjct: 768 HLPRPNITQSCQLRLCGHWEVGSPWSQCS 796
Score = 33.5 bits (75), Expect = 1.3
Identities = 29/103 (28%), Positives = 39/103 (37%), Gaps = 25/103 (24%)
Query: 566 CGLSMWCRQGQC-VKFGELG-----------PRP---------IHGQWSAWSKWSECSRT 604
CG RQ QC +FG G PRP + G W S WS+CS
Sbjct: 739 CGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVR 798
Query: 605 CGGGVKFQERHC-NNPKPQYGGLFC---PGSSRIYQLCNINPC 643
CG G + ++ C N + C P + C++ PC
Sbjct: 799 CGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
Score = 33.1 bits (74), Expect = 1.7
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 3/54 (5%)
Query: 598 WSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQL--CNINPCNENSLD 649
WS CSR+C GG + +E C + Q CP R + CN PC++ D
Sbjct: 979 WSPCSRSCQGGTQTREVQCLSTN-QTLSTRCPPQLRPSRKRPCNSQPCSQRPDD 1031
Score = 31.6 bits (70), Expect = 4.8
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 8/48 (16%)
Query: 993 PQWSLGPWSQ---CSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRP 1037
P+ GPW Q CS+ CG GV++R C+ + P SLP P
Sbjct: 43 PEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHP-----SLPLP 85
Score = 30.8 bits (68), Expect = 8.2
Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Query: 1046 GRCPKNSRLQWVASSWSECSATCGLGVRKREMKC 1079
G+ P+ WV W+ CS CG+GV++R C
Sbjct: 40 GQGPEGVWGPWV--QWASCSQPCGVGVQRRSRTC 71
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 316 bits (810), Expect = 8e-86
Identities = 219/725 (30%), Positives = 321/725 (44%), Gaps = 142/725 (19%)
Query: 628 CPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCK 687
C G+ R Y+LCN N C E+S R QCA YN+KPF G FY+W+P+ +V+ +C+L C+
Sbjct: 291 CIGAYRQYKLCNTNVCPESSRSIREVQCASYNNKPFMGRFYEWEPFAEVKGNRKCELNCQ 350
Query: 688 AENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNST 747
A + F+ + KV DGTPC N +C+ G C+ +GCD LGS V D CGVC GDN+
Sbjct: 351 AMGYRFYVRQAEKVIDGTPCDQNGTAICVSGQCKSIGCDDYLGSDKVVDKCGVCGGDNTG 410
Query: 748 CKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSID 807
C+ G++ + + Y+ VV IP GA I I E+ S++YLA+RS S + + G W+ID
Sbjct: 411 CQVVSGVFKHALTSLGYHRVVEIPEGATKINITEMYKSNNYLALRSRSGRSIINGNWAID 470
Query: 808 WPGEFPFAGTTFEYQR----SFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYAL--P 861
PG++ GT F Y+R S E A GPTNE L ++ Q NPG+ ++Y +
Sbjct: 471 RPGKYEGGGTMFTYKRPNEISSTAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGT 530
Query: 862 KVMNGTPPATKRPAYTWS---IVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTK 918
++ P +RP ++ + + N + LR + ++ +S SA+T
Sbjct: 531 NAISPQVPPHRRPGEPFNGQMVTEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSE-SAQTF 589
Query: 919 PVTEPK----------ICNAFSCPAYWMPGEW-----STCSKACAGGQQSRKIQCVQKKP 963
PV P + A P W + CS C G Q +CV +
Sbjct: 590 PVRHPDRFSPHRPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHR-- 647
Query: 964 FQKEEAVLHSLCPVS-TPT-QVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCK-- 1019
E S C S PT + + CN CP W +G WS+CSKTCG G++ R++LC+
Sbjct: 648 -STHEEAPESYCDSSMKPTPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQV 706
Query: 1020 -GSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQW-VASSWSECSATCGLGVRKREM 1077
+ + T+ +C L +PE C L C +W + + W+ CS CG+G R R++
Sbjct: 707 YANRSLTVQPYRCQHLEKPETTSTCQLKICS-----EWQIRTDWTSCSVPCGVGQRTRDV 761
Query: 1078 KC------------------------SEKGFQGK---LITFPER--------------RC 1096
KC + G K L + ER C
Sbjct: 762 KCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVC 821
Query: 1097 RNIKKPNLDLEETCNRRACPAHPVYN----MVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ 1152
+L LE N R A P N W++ W QC++ CG G Q R V CV+
Sbjct: 822 MTNHVSSLPLEGCGNNRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVR 881
Query: 1153 QGRPS------SSCLLHQKPPVLRACNTNFCPA--------------------------- 1179
+ + S C +KPP ++C+ C A
Sbjct: 882 KNADTFEVLDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLS 941
Query: 1180 --------------PEKRE-----------DPSCVDFFNWCHLVPQHGVCNHKFYGKQCC 1214
PE+RE D +C D + C++V Q +C + +Y CC
Sbjct: 942 DDMTLSNLCDPQLKPEERESCNPQDCVPEVDENCKDKYYNCNVVVQARLCVYNYYKTACC 1001
Query: 1215 KSCTR 1219
SCTR
Sbjct: 1002 ASCTR 1006
Score = 42.7 bits (99), Expect = 0.002
Identities = 16/27 (59%), Positives = 17/27 (62%)
Query: 590 GQWSAWSKWSECSRTCGGGVKFQERHC 616
G W AW WS CSR+C GGV Q R C
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 31.6 bits (70), Expect = 4.8
Identities = 17/64 (26%), Positives = 28/64 (43%), Gaps = 18/64 (28%)
Query: 553 CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQ 612
C++ P E C + C F ++G +WSECS+TCG G++ +
Sbjct: 658 CDSSMKPTPEEEPCNIF------PCPAFWDIG------------EWSECSKTCGLGMQHR 699
Query: 613 ERHC 616
+ C
Sbjct: 700 QVLC 703
Score = 30.8 bits (68), Expect = 8.2
Identities = 22/87 (25%), Positives = 31/87 (35%), Gaps = 7/87 (8%)
Query: 584 GPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRI------YQL 637
GP +W A S WS+CS CG G + +E C + P Q
Sbjct: 848 GPCTGKVEWFAGS-WSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQS 906
Query: 638 CNINPCNENSLDFRAQQCAEYNSKPFR 664
C++ PC C++ FR
Sbjct: 907 CHLKPCGAKWFSTEWSMCSKSCQGGFR 933
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 290 bits (741), Expect = 8e-78
Identities = 160/493 (32%), Positives = 235/493 (47%), Gaps = 63/493 (12%)
Query: 628 CPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCK 687
C G S + C+ PC D RA QCA +NS+ F G YQW+P+T+V+ RC+L C+
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEFMGQLYQWEPFTEVQGSQRCELNCR 423
Query: 688 AENFEFFFAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNST 747
F F+ + KV+DGT C P D+C+ G C GCD LGS D CGVC GD+ST
Sbjct: 424 PRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCGGDDST 483
Query: 748 CKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSID 807
C+ G ++ Y ++ IPAGA ++I +L+ SS+YLA+R + + G W++D
Sbjct: 484 CRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQLRPSSNYLALRGPGGRSIINGNWAVD 543
Query: 808 WPGEFPFAGTTFEYQ---RSFNRPERLYAPGPTNETLVFEILMQGKNPGIAWKYAL---- 860
PG + GT F Y R + E L A GPT + + ++ Q +NPG+ ++Y +
Sbjct: 544 PPGSYRAGGTVFRYNRPPREEGKGESLSAEGPTTQPVDVYMIFQEENPGVFYQYVISSPP 603
Query: 861 ----------------PKVMNGTPPATKRP------------------------------ 874
P+++ PP P
Sbjct: 604 PILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQVRIPQMPAPPHPRTPLGS 663
Query: 875 --AYTWSIVQSECSVSCGGGYINVKAICL-RDQNTQVNSSFCSAKTKPVTEPKICNAFSC 931
AY + S CS SCG G +C+ R+ +++ C+A +P P+ C+ C
Sbjct: 664 PAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPC 723
Query: 932 PAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHAC 991
P YW GEW++CS++C G Q R++QC Q+ + P Q+C C
Sbjct: 724 PPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC 783
Query: 992 PPQWSLG-PWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTS-LPRPELQEGCVLGRCP 1049
W +G PWSQCS CGRG R R++ C G+ + + E +C S P+P +E C +G C
Sbjct: 784 -GHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC- 841
Query: 1050 KNSRLQWVASSWS 1062
W S WS
Sbjct: 842 ---TTAWFHSDWS 851
Score = 90.1 bits (222), Expect = 1e-17
Identities = 60/189 (31%), Positives = 85/189 (44%), Gaps = 21/189 (11%)
Query: 995 WSLGPWSQCSKTCGRGVRKRELLC-KGSAAETLPESQCTSLPRPELQ-EGCVLGRCPKNS 1052
W S CS +CG+GV + LC + E L E C + RP E C CP
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPP-- 725
Query: 1053 RLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNR 1112
W A W+ CS +CG G + R+++C ++ F G + P RC ++ +PN + ++C
Sbjct: 726 --YWEAGEWTSCSRSCGPGTQHRQLQCRQE-FGGGGSSVPPERCGHLPRPN--ITQSCQL 780
Query: 1113 RACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSS---CLL-HQKPPV 1168
R C V PW QC+V CG G ++R V CV S C +PP
Sbjct: 781 RLCGHWEV--------GSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPS 832
Query: 1169 LRACNTNFC 1177
AC+ C
Sbjct: 833 REACDMGPC 841
Score = 38.5 bits (88), Expect = 0.040
Identities = 14/33 (42%), Positives = 19/33 (57%)
Query: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ 622
G W W +W+ CS+ CG GV+ + R C P Q
Sbjct: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQ 77
Score = 37.0 bits (84), Expect = 0.11
Identities = 15/60 (25%), Positives = 28/60 (46%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
S+CSV CG G + + C+ + +V+ C++ + C+ C W +WS+
Sbjct: 793 SQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSS 852
Score = 35.0 bits (79), Expect = 0.44
Identities = 25/89 (28%), Positives = 37/89 (41%), Gaps = 24/89 (26%)
Query: 585 PRPIHGQ-----WSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSS------- 632
P P HG W A +W+ CSR+CG G + ++ C + ++GG GSS
Sbjct: 715 PEPCHGTPCPPYWEA-GEWTSCSRSCGPGTQHRQLQC---RQEFGG---GGSSVPPERCG 767
Query: 633 -----RIYQLCNINPCNENSLDFRAQQCA 656
I Q C + C + QC+
Sbjct: 768 HLPRPNITQSCQLRLCGHWEVGSPWSQCS 796
Score = 33.5 bits (75), Expect = 1.3
Identities = 29/103 (28%), Positives = 39/103 (37%), Gaps = 25/103 (24%)
Query: 566 CGLSMWCRQGQC-VKFGELG-----------PRP---------IHGQWSAWSKWSECSRT 604
CG RQ QC +FG G PRP + G W S WS+CS
Sbjct: 739 CGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVR 798
Query: 605 CGGGVKFQERHC-NNPKPQYGGLFC---PGSSRIYQLCNINPC 643
CG G + ++ C N + C P + C++ PC
Sbjct: 799 CGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC 841
Score = 31.6 bits (70), Expect = 4.8
Identities = 18/48 (37%), Positives = 24/48 (50%), Gaps = 8/48 (16%)
Query: 993 PQWSLGPWSQ---CSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRP 1037
P+ GPW Q CS+ CG GV++R C+ + P SLP P
Sbjct: 43 PEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQLHP-----SLPLP 85
Score = 30.8 bits (68), Expect = 8.2
Identities = 13/34 (38%), Positives = 19/34 (55%), Gaps = 2/34 (5%)
Query: 1046 GRCPKNSRLQWVASSWSECSATCGLGVRKREMKC 1079
G+ P+ WV W+ CS CG+GV++R C
Sbjct: 40 GQGPEGVWGPWV--QWASCSQPCGVGVQRRSRTC 71
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 286 bits (732), Expect = 8e-77
Identities = 199/665 (29%), Positives = 284/665 (42%), Gaps = 112/665 (16%)
Query: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLD 649
G W AW WS+CSRTCGGG + R C G C G + Y+ C+ + C ++ D
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAED 129
Query: 650 FRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSP 709
FRAQQC+ YN ++G +Y+W P + C L C A+ ++ KV DGT C+
Sbjct: 130 FRAQQCSAYNDVQYQGHYYEWLPRYN-DPAAPCALKCHAQGQNLVVELAPKVLDGTRCNT 188
Query: 710 NKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKG---LYLNQHKANEYYP 766
+ D+CI G+C+ VGCD +LGS A D CGVC GD STC+ +G +++ K E
Sbjct: 189 DSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKREE--N 246
Query: 767 VVLIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFN 826
V+ +P G+RS+ I + ++ ++L G S + PG F TT E+QR
Sbjct: 247 VIAVPLGSRSVRITVKGPAHLFIESKTLQGS---KGEHSFNSPGVFLVENTTVEFQRGSE 303
Query: 827 RPERLYAPGPTNETLVFEILMQGKNPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SEC 885
R + PGP +F+ + + + ++ W C
Sbjct: 304 R-QTFKIPGPLMADFIFKTRYTAAKDSVVQFFFYQPI-----------SHQWRQTDFFPC 351
Query: 886 SVSCGGGYINVKAICLRDQ-NTQVNSSFC---SAKTKPVTEPKICNAFSCPA-------- 933
+V+CGGGY A C+ + V +C KP + K C+ CP+
Sbjct: 352 TVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCPSSDGFKEIM 411
Query: 934 ---------YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVS-TPTQV 983
W W+ CS +C GG Q R CV++ + V C + P +
Sbjct: 412 PYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVM 471
Query: 984 QACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGC 1043
Q CN C P+W WSQC+ TCGRG+R R +LC E + C + ++E C
Sbjct: 472 QTCNLFDC-PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHV--GGCNPQLKLHIKEEC 528
Query: 1044 VL--------GRCPKNSRLQW-------------------VASSWSECSATCGLGVRKRE 1076
V+ + P ++L W + WS CS TCG GV+ RE
Sbjct: 529 VIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVRE 588
Query: 1077 MKCSEKGFQGKLITF-------PERRCRNIKKPNLDLEETCNRRACPAHPV--------- 1120
+KC L+TF PE C P L E C AC P
Sbjct: 589 VKCR------VLLTFTQTETELPEEECEG---PKLPTERPCLLEACDESPASRELDIPLP 639
Query: 1121 --YNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV----QQGRPSSSC-LLHQKPPVLRACN 1173
W + CT TC GG Q C+ QQ S C ++H+ P + +ACN
Sbjct: 640 EDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACN 699
Query: 1174 TNFCP 1178
T CP
Sbjct: 700 TEPCP 704
Score = 133 bits (335), Expect = 9e-31
Identities = 93/343 (27%), Positives = 138/343 (40%), Gaps = 59/343 (17%)
Query: 870 ATKRPAYT---WSIVQSECSVSCGGGYINVKAICLR------DQNTQVNSSFCSAKTKPV 920
AT+ P + WS CS +CG G + V+ + R T++ C P
Sbjct: 562 ATEEPTFIPEPWSA----CSTTCGPG-VQVREVKCRVLLTFTQTETELPEEECEGPKLPT 616
Query: 921 TEPKICNAFS-CPAY----------------WMPGEWSTCSKACAGGQQSRKIQCVQKKP 963
P + A PA W ++ C+ C GG Q C+
Sbjct: 617 ERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH--- 673
Query: 964 FQKEEAVLHSLCPV--STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGS 1021
Q ++ V SLC + P QACN+ CPP+W +G W CS TCG G++ R++ C
Sbjct: 674 IQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP 733
Query: 1022 AAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSE 1081
P +C +P + C CP W W +CS TCG G + R + C +
Sbjct: 734 GETPAPPEECRD-EKPHALQACNQFDCPPG----WHIEEWQQCSRTCGGGTQNRRVTCRQ 788
Query: 1082 KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGG 1141
G + + C+ P ++C R CP H + G W +C+V+CG
Sbjct: 789 LLTDGSFLNLSDELCQG---PKASSHKSCARTDCPPH----LAVG----DWSKCSVSCGV 837
Query: 1142 GVQTRSVHC---VQQGR--PSSSCLLHQKP--PVLRACNTNFC 1177
G+Q R C +GR P S + P P++R+C C
Sbjct: 838 GIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPEC 880
Score = 125 bits (314), Expect = 2e-28
Identities = 100/347 (28%), Positives = 142/347 (40%), Gaps = 69/347 (19%)
Query: 885 CSVSCGGGYINVKAICLRD----QNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEW 940
CSVSCGGG +C+ + + QV C KP + CN F CP W+ EW
Sbjct: 430 CSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPKVM-QTCNLFDCPK-WIAMEW 487
Query: 941 STCSKACAGGQQSRKIQCV------------QKKPFQKEEAVLHSLC-------PVSTPT 981
S C+ C G + R + C+ Q K KEE V+ C PV
Sbjct: 488 SQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKL 547
Query: 982 -------QVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAET-----LPES 1029
+++ P + PWS CS TCG GV+ RE+ C+ T LPE
Sbjct: 548 PWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEE 607
Query: 1030 QCTSLPRPELQEGCVLGRC-------------PKNSRL--QWVASSWSECSATCGLGVRK 1074
+C P+ + C+L C P++S W + ++ C+ATC G ++
Sbjct: 608 ECEG-PKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQE 666
Query: 1075 REMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQ 1134
C Q T + C + +P + + CN CP W+ W
Sbjct: 667 AIAVCLHIQTQQ---TVNDSLCDMVHRPPA-MSQACNTEPCPPR--------WHVGSWGP 714
Query: 1135 CTVTCGGGVQTRSVHCVQQGR---PSSSCLLHQKPPVLRACNTNFCP 1178
C+ TCG G+QTR V+C+ G P C +KP L+ACN CP
Sbjct: 715 CSATCGVGIQTRDVYCLHPGETPAPPEECR-DEKPHALQACNQFDCP 760
Score = 120 bits (300), Expect = 1e-26
Identities = 93/334 (27%), Positives = 139/334 (41%), Gaps = 59/334 (17%)
Query: 897 KAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAG-GQQSRK 955
K L+ NT+ NS+ + + P EP +W PG WS CS C G + ++
Sbjct: 1401 KKYILQATNTRTNSNDPTGEPPP-QEP----------FWEPGNWSHCSATCGHLGARIQR 1449
Query: 956 IQCVQKKPFQKEEAVL-HSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKR 1014
QCV + EA+ H P++ + CN CP +W WSQCS +CG G R
Sbjct: 1450 PQCVMANGQEVSEALCDHLQKPLAG---FEPCNIRDCPARWFTSVWSQCSVSCGEGYHSR 1506
Query: 1015 ELLCKGSAA----ETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATC-G 1069
++ CK + A + + C RP ++ C C +QW + C C G
Sbjct: 1507 QVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC-----VQWEPGN--RCPGRCMG 1559
Query: 1070 LGVR--KREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGW 1127
VR +R C + C + K+P L C AC W
Sbjct: 1560 RAVRMQQRHTACQHNS--------SDSNCDDRKRPTL--RRNCTSGACDVC--------W 1601
Query: 1128 YSLPWQQCTVTCGGGVQTRSVHCV--QQGRPSSS--CLLHQKPPVLRACNTNFCPAPEKR 1183
++ PW+ CT CG G Q+R V C+ + +P + C+ +KP R C C
Sbjct: 1602 HTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC------ 1655
Query: 1184 EDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSC 1217
D C D ++C V +C+ Y ++CC+SC
Sbjct: 1656 -DRDCTDTTHYCMFVKHLNLCSLDRYKQRCCQSC 1688
Score = 99.8 bits (247), Expect = 1e-20
Identities = 53/170 (31%), Positives = 76/170 (44%), Gaps = 6/170 (3%)
Query: 885 CSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTCS 944
CS +CG G CL T C + + CN F CP W EW CS
Sbjct: 715 CSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQA--CNQFDCPPGWHIEEWQQCS 772
Query: 945 KACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCS 1004
+ C GG Q+R++ C Q + LC + ++C CPP ++G WS+CS
Sbjct: 773 RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHLAVGDWSKCS 832
Query: 1005 KTCGRGVRKRELLCKGSAAE----TLPESQCTSLPRPELQEGCVLGRCPK 1050
+CG G+++R+ +C+ AA+ L E C LP L C + C K
Sbjct: 833 VSCGVGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSK 882
Score = 73.9 bits (180), Expect = 8e-13
Identities = 54/199 (27%), Positives = 84/199 (42%), Gaps = 15/199 (7%)
Query: 860 LPKVMNGTPPATKR--PAYTWSIVQSECSVSCGGGYINVKAICLRDQNT----QVNSSFC 913
L K + G P R PA ++ V S+CSVSCG GY + + C R + V+ C
Sbjct: 1468 LQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRAC 1527
Query: 914 SAKTKPVTEPKICNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHS 973
+ K +P+ K C C W PG C G R ++ Q+ + + +
Sbjct: 1528 APKDRPLGR-KPCFGHPC-VQWEPG------NRCPGRCMGRAVRMQQRHTACQHNSSDSN 1579
Query: 974 LCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLC-KGSAAETLPESQCT 1032
PT + C S AC W GPW C+ CGRG + R++ C + + + + C
Sbjct: 1580 CDDRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCV 1639
Query: 1033 SLPRPELQEGCVLGRCPKN 1051
+P C+ C ++
Sbjct: 1640 QKKKPISWRHCLGPSCDRD 1658
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 275 bits (704), Expect = 1e-73
Identities = 197/671 (29%), Positives = 293/671 (43%), Gaps = 117/671 (17%)
Query: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLD 649
G W AW WSECSRTCGGG + R C + K C G + Y+ C+ C + D
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAGD 87
Query: 650 FRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSP 709
FRAQQC+ +N G FY+W P + + ++ C L C+A+ ++ KV DGT C
Sbjct: 88 FRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
Query: 710 NKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEY-YPVV 768
D+CI G+C++VGCDH+LGS D CGVC GD STC+ +G Y +Q A + VV
Sbjct: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
Query: 769 LIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRP 828
IP G+R I + YL ++L G S+ G F ++ ++Q+ F
Sbjct: 207 AIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSLSSTGTFLVDNSSVDFQK-FPDK 262
Query: 829 ERLYAPGPTNETLVFEILMQGK-NPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SECS 886
E L GP + +I G + + + + P + + W CS
Sbjct: 263 EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII------------HRWRETDFFPCS 310
Query: 887 VSCGGGYINVKAIC--LRDQNTQVNSSFC---SAKTKPVTEPKICNAFSCPA-------- 933
+CGGGY A C LR N V +C KP + + CN CPA
Sbjct: 311 ATCGGGYQLTSAECYDLR-SNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIM 369
Query: 934 ---------YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ-- 982
W W+ CS +C GG QSR + CV++ +V C + TP
Sbjct: 370 PYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC-MYTPKMPI 428
Query: 983 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG 1042
Q CN C P+W WS C+ TCG+G+R R +LC + C+ +P ++E
Sbjct: 429 AQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEE 485
Query: 1043 CVL--------GRCPKNSRLQW-------------------VASSWSECSATCGLGVRKR 1075
C++ + P ++L W + +WS C+ TCG+G + R
Sbjct: 486 CIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVR 545
Query: 1076 EMKCSE-KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPV-------------- 1120
++C F + P C K ++RAC A P
Sbjct: 546 IVRCQVLLSFSQSVADLPIDECEGPK--------PASQRACYAGPCSGEIPEFNPDETDG 597
Query: 1121 -------YNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV--QQGRPSSS--CLLHQKPP-V 1168
++ + W + +C+ +CGGGVQ V C+ Q P+ C+ ++PP +
Sbjct: 598 LFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQL 657
Query: 1169 LRACNTNFCPA 1179
L++CN + CPA
Sbjct: 658 LKSCNLDPCPA 668
Score = 150 bits (380), Expect = 5e-36
Identities = 79/204 (38%), Positives = 102/204 (50%), Gaps = 12/204 (5%)
Query: 883 SECSVSCGGGYINVKAICLRDQNTQ-VNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWS 941
++CS SCGGG CL Q + + C +P K CN CPA W G+WS
Sbjct: 617 TKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWS 676
Query: 942 TCSKACAGGQQSRKIQCVQKKPFQKEEAVL--HSLCPVSTPTQVQACNSHACPPQWSLGP 999
CS C G Q+R + C + E V+ LC P+ VQACN CPP W
Sbjct: 677 PCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQ 736
Query: 1000 WSQCSKTCGRGVRKRELLCKGSAAE----TLPESQCTSLPRPELQEGCVLGRCPKNSRLQ 1055
W CS+TCG GV+KRE+LCK A+ LPE+ C S +P Q+ C CP +
Sbjct: 737 WQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC-SASKPACQQACKKDDCPS----E 791
Query: 1056 WVASSWSECSATCGLGVRKREMKC 1079
W+ S W+ECS +CG G + R C
Sbjct: 792 WLLSDWTECSTSCGEGTQTRSAIC 815
Score = 138 bits (348), Expect = 3e-32
Identities = 69/211 (32%), Positives = 106/211 (50%), Gaps = 12/211 (5%)
Query: 876 YTWSIVQ-SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAY 934
Y WS+ + + CS SCG + + +T+VN + C+ K +P +P CN CP+
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSR 1548
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCP--VSTPTQVQACNSHACP 992
WM WS C+++C GG Q+R++ C + K V + +C P QACN C
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC- 1607
Query: 993 PQWSLGPWSQCSKTC---GRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCP 1049
+W+ W QC+ C V+ R++ C+ TLP QC++LPRP + C C
Sbjct: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEAC- 1666
Query: 1050 KNSRLQWVASSWSECSATCG-LGVRKREMKC 1079
+ W S W+ C+ATCG G + R ++C
Sbjct: 1667 ---SVHWRVSLWTLCTATCGNYGFQSRRVEC 1694
Score = 135 bits (341), Expect = 2e-31
Identities = 77/260 (29%), Positives = 120/260 (46%), Gaps = 32/260 (12%)
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVST--PTQVQACNSHACP 992
W ++ CS++C GG Q + C+ K Q E +LC S P +++CN CP
Sbjct: 611 WEYEGFTKCSESCGGGVQEAVVSCLNK---QTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
Query: 993 PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPES-----QCTSLPRPELQEGCVLGR 1047
+W +G WS CS TCG G++ R++ C + + E+ + P+P + C
Sbjct: 668 ARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFN 727
Query: 1048 CPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLE 1107
CP W + W CS TCG GV+KRE+ C ++ G + PE C + KP +
Sbjct: 728 CPP----AWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFC-SASKP--ACQ 780
Query: 1108 ETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQK-- 1165
+ C + CP+ W W +C+ +CG G QTRS C + + S +++
Sbjct: 781 QACKKDDCPSE--------WLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLC 832
Query: 1166 PPV-----LRACNTNFCPAP 1180
PP+ +R C C P
Sbjct: 833 PPLPFSSSIRPCMLATCARP 852
Score = 118 bits (296), Expect = 3e-26
Identities = 84/298 (28%), Positives = 123/298 (41%), Gaps = 42/298 (14%)
Query: 934 YWMPGEWSTCSKACAG-GQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACP 992
+W +TCS +C G Q +++C+ E H V Q ACN CP
Sbjct: 1490 WWSVDRLATCSASCGNRGVQQPRLRCLLNST---EVNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 993 PQWSLGPWSQCSKTCGRGVRKRELLC---KGSAAET-LPESQCTSLP-RPELQEGCVLGR 1047
+W + WS C+++CG GV+ R + C K S T + CT + RP + C
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 1048 CPKNSRLQWVASSWSECSATC---GLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNL 1104
C ++W SSW +C+ C L V+ R++ C + IT P +C + +P
Sbjct: 1607 C-----VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDG----ITLPSEQCSALPRPVS 1657
Query: 1105 DLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGG-GVQTRSVHCVQ----QGRPSSS 1159
+ C AC H W W CT TCG G Q+R V CV + P
Sbjct: 1658 T--QNCWSEACSVH--------WRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHL 1707
Query: 1160 CLLHQKPPVLRACNTNFCPAPEKREDPSCVDFFNWCHLVPQHGVCNHKFYGKQCCKSC 1217
C +P + CN C E+ C D +C V Q +C + +CC +C
Sbjct: 1708 CSWGPRPANWQRCNITPC------ENMECRDTTRYCEKVKQLKLCQLSQFKSRCCGTC 1759
Score = 108 bits (271), Expect = 2e-23
Identities = 57/186 (30%), Positives = 85/186 (45%), Gaps = 11/186 (5%)
Query: 878 WSIVQ-SECSVSCGGGYINVKAICLRDQNTQVNSSFCSA-----KTKPVTEPKICNAFSC 931
W I + S CS++CG G C + ++N + A + KP T + CN F+C
Sbjct: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTV-QACNRFNC 728
Query: 932 PAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHAC 991
P W P +W CS+ C GG Q R++ C Q+ + + C S P QAC C
Sbjct: 729 PPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKDDC 788
Query: 992 PPQWSLGPWSQCSKTCGRGVRKRELLC----KGSAAETLPESQCTSLPRPELQEGCVLGR 1047
P +W L W++CS +CG G + R +C K + + + C LP C+L
Sbjct: 789 PSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSIRPCMLAT 848
Query: 1048 CPKNSR 1053
C + R
Sbjct: 849 CARPGR 854
Score = 36.6 bits (83), Expect = 0.15
Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 8/63 (12%)
Query: 1127 WYSLPWQQCTVTCGGGVQTRSVHC--VQQGRPSSSCLLHQKP------PVLRACNTNFCP 1178
W + C+ TCGGG Q S C ++ R + H P P L+ CN + CP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1179 APE 1181
A +
Sbjct: 361 ASD 363
Score = 33.5 bits (75), Expect = 1.3
Identities = 14/25 (56%), Positives = 18/25 (72%), Gaps = 2/25 (8%)
Query: 594 AW--SKWSECSRTCGGGVKFQERHC 616
AW ++W CSRTCGGGV+ +E C
Sbjct: 731 AWYPAQWQPCSRTCGGGVQKREVLC 755
Score = 33.1 bits (74), Expect = 1.7
Identities = 31/114 (27%), Positives = 46/114 (40%), Gaps = 17/114 (14%)
Query: 508 DKLPGQIYDADTQCKWQFGAKAKL---CSLGFVKDICKSLWCHRVGHRCETKFMPAAEGT 564
D L G + D D W++ K C G + + L + AE
Sbjct: 596 DGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCL---------NKQTREPAEEN 646
Query: 565 VCGLSMWCRQGQCVKFGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNN 618
+C S R Q +K L P P +W KWS CS TCG G++ ++ C++
Sbjct: 647 LCVTSR--RPPQLLKSCNLDPCP--ARWEI-GKWSPCSLTCGVGLQTRDVFCSH 695
Score = 31.6 bits (70), Expect = 4.8
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 9/76 (11%)
Query: 593 SAW--SKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDF 650
S W + WS C+R+CGGGV Q R K + G+ P S+ + P + + +
Sbjct: 1547 SRWMVTSWSACTRSCGGGV--QTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACN- 1603
Query: 651 RAQQCAEYNSKPFRGW 666
Q C E+ F W
Sbjct: 1604 -QQLCVEW---AFSSW 1615
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 236 bits (603), Expect = 8e-62
Identities = 172/554 (31%), Positives = 259/554 (46%), Gaps = 76/554 (13%)
Query: 40 ASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDIL----HNGRKKRSAQNAR- 94
A+ A A+D G G + + PV D+ G +SH + G + R A R
Sbjct: 35 ANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRT 94
Query: 95 ------------SSLHYRFSAFGQELHLELKPSA-ILSSHFIVQVLGKDGASETQKPEVQ 141
S L Y + FG++LHL L+P+A +++ ++ G+ G + + P +
Sbjct: 95 PSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVE-PLLG 153
Query: 142 QCFYQGFIRN-DSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPH 200
C Y G + +SSVA+S C GL+GLIR + EF I PL + LA + H
Sbjct: 154 SCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRV----H 209
Query: 201 VLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKY 260
V+Y+R P P + + + R L
Sbjct: 210 VVYRRPPTSP--------------PLGGPQALDTGASLDSLDSLSRALGV---------- 245
Query: 261 APKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILT 320
+E+ +S R R + N+E L+ D +V+ HGK +V Y+LT
Sbjct: 246 ------------LEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLT 293
Query: 321 VMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLIN-HHADQSLNSFCQW---QSALI 376
+MN+V+ ++ D ++G+ INVV+V +ILL LI + QSL + C+W Q
Sbjct: 294 LMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPD 353
Query: 377 GKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAH 436
+ + HDHAI LT D P G+AP++GMC RSCT+N + G AF +AH
Sbjct: 354 TGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAH 408
Query: 437 ESGHNFGMIHDGEGNPC--RKAEGNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCL 494
E+GH GM HDG+GN C G+IM+P + F WS CS+Q L ++L + CL
Sbjct: 409 ETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCL 466
Query: 495 VDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVG--HR 552
+D+P A + +LPG Y + QC++ FG +C+ D CK LWC +
Sbjct: 467 LDDP-FAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF 525
Query: 553 CETKFMPAAEGTVC 566
C+TK P +GT+C
Sbjct: 526 CKTKKGPPLDGTMC 539
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 236 bits (601), Expect = 1e-61
Identities = 158/502 (31%), Positives = 228/502 (45%), Gaps = 63/502 (12%)
Query: 590 GQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLD 649
G W AW WSECSRTCGGG + R C + K C G + Y+ C+ C + D
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAGD 87
Query: 650 FRAQQCAEYNSKPFRGWFYQWKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCSP 709
FRAQQC+ +N G FY+W P + + ++ C L C+A+ ++ KV DGT C
Sbjct: 88 FRAQQCSAHNDVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVELAPKVLDGTRCYT 146
Query: 710 NKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEY-YPVV 768
D+CI G+C++VGCDH+LGS D CGVC GD STC+ +G Y +Q A + VV
Sbjct: 147 ESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVV 206
Query: 769 LIPAGARSIEIQELQVSSSYLAVRSLSQKYYLTGGWSIDWPGEFPFAGTTFEYQRSFNRP 828
IP G+R I + YL ++L G S+ G F ++ ++Q+ F
Sbjct: 207 AIPYGSRHIRLVLKGPDHLYLETKTLQG---TKGENSLSSTGTFLVDNSSVDFQK-FPDK 262
Query: 829 ERLYAPGPTNETLVFEILMQGK-NPGIAWKYALPKVMNGTPPATKRPAYTWSIVQ-SECS 886
E L GP + +I G + + + + P + + W CS
Sbjct: 263 EILRMAGPLTADFIVKIRNSGSADSTVQFIFYQPII------------HRWRETDFFPCS 310
Query: 887 VSCGGGYINVKAIC--LRDQNTQVNSSFC---SAKTKPVTEPKICNAFSCPA-------- 933
+CGGGY A C LR N V +C KP + + CN CPA
Sbjct: 311 ATCGGGYQLTSAECYDLR-SNRVVADQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIM 369
Query: 934 ---------YWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQ-- 982
W W+ CS +C GG QSR + CV++ +V C + TP
Sbjct: 370 PYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKC-MYTPKMPI 428
Query: 983 VQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEG 1042
Q CN C P+W WS C+ TCG+G+R R +LC + C+ +P ++E
Sbjct: 429 AQPCNIFDC-PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG--MHTGGCSPKTKPHIKEE 485
Query: 1043 CVL--------GRCPKNSRLQW 1056
C++ + P ++L W
Sbjct: 486 CIVPTPCYKPKEKLPVEAKLPW 507
Score = 88.6 bits (218), Expect = 3e-17
Identities = 55/199 (27%), Positives = 86/199 (43%), Gaps = 32/199 (16%)
Query: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSL------PRPELQEGCVLGR 1047
+W + CS TCG G + C + + Q P+P+LQE C L
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQE-CNLDP 358
Query: 1048 CPKNSRLQ-------------WVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPER 1094
CP + + W A+ W+ CS++CG G++ R + C E+ QG + + E
Sbjct: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
Query: 1095 RCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCV-QQ 1153
+C + P + + + CN CP W + W CTVTCG G++ R V C+ +
Sbjct: 419 KC--MYTPKMPIAQPCNIFDCPK---------WLAQEWSPCTVTCGQGLRYRVVLCIDHR 467
Query: 1154 GRPSSSCLLHQKPPVLRAC 1172
G + C KP + C
Sbjct: 468 GMHTGGCSPKTKPHIKEEC 486
Score = 81.6 bits (200), Expect = 4e-15
Identities = 45/171 (26%), Positives = 70/171 (40%), Gaps = 34/171 (19%)
Query: 935 WMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCP-----VSTPTQVQACNSH 989
W ++ CS C GG Q +C + V C + ++Q CN
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYD---LRSNRVVADQYCHYYPENIKPKPKLQECNLD 357
Query: 990 ACP-----------------PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAE----TLPE 1028
CP P+W PW+ CS +CG G++ R + C + ++ E
Sbjct: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEE 417
Query: 1029 SQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKC 1079
+C P+ + + C + CPK W+A WS C+ TCG G+R R + C
Sbjct: 418 WKCMYTPKMPIAQPCNIFDCPK-----WLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 69.7 bits (169), Expect = 2e-11
Identities = 46/146 (31%), Positives = 70/146 (47%), Gaps = 29/146 (19%)
Query: 1055 QWVASSWSECSATCGLGVRKREMKCSEKGFQGKLIT-----FPERRCRNIK-KPNLDLEE 1108
+W + + CSATCG G + +C + + +PE NIK KP L +
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPE----NIKPKPKL---Q 352
Query: 1109 TCNRRACPA---------HPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQ---QGRP 1156
CN CPA + +Y+ + W + PW C+ +CGGG+Q+R+V CV+ QG
Sbjct: 353 ECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHV 412
Query: 1157 SS----SCLLHQKPPVLRACNTNFCP 1178
+S C+ K P+ + CN CP
Sbjct: 413 TSVEEWKCMYTPKMPIAQPCNIFDCP 438
Score = 36.6 bits (83), Expect = 0.15
Identities = 20/63 (31%), Positives = 28/63 (44%), Gaps = 8/63 (12%)
Query: 1127 WYSLPWQQCTVTCGGGVQTRSVHC--VQQGRPSSSCLLHQKP------PVLRACNTNFCP 1178
W + C+ TCGGG Q S C ++ R + H P P L+ CN + CP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1179 APE 1181
A +
Sbjct: 361 ASD 363
Score = 33.9 bits (76), Expect = 0.97
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 3/43 (6%)
Query: 1061 WSECSATCGLGVRKREMKC-SEKGFQGKLITFPERRCRNIKKP 1102
WSECS TCG G +C S K +G+ I + R C N+ P
Sbjct: 42 WSECSRTCGGGASYSLRRCLSSKSCEGRNIRY--RTCSNVDCP 82
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 56,868,442
Number of Sequences: 37866
Number of extensions: 2963683
Number of successful extensions: 8284
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 94
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 6049
Number of HSP's gapped (non-prelim): 806
length of query: 1221
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1107
effective length of database: 13,930,794
effective search space: 15421388958
effective search space used: 15421388958
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.