Guide to the Human Genome
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Search of human proteins with 40804748

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40804748 LIM and senescent cell antigen-like domains 2
isoform 2 [Homo sapiens]
         (365 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40804748 LIM and senescent cell antigen-like domains 2 isofor...   797   0.0  
gi|238859658 LIM and senescent cell antigen-like domains 2 isofo...   742   0.0  
gi|238776786 LIM and senescent cell antigen-like domains 2 isofo...   742   0.0  
gi|238776788 LIM and senescent cell antigen-like domains 2 isofo...   739   0.0  
gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo ...   639   0.0  
gi|239741720 PREDICTED: hypothetical protein XP_002342298 [Homo ...   320   2e-87
gi|239758027 PREDICTED: similar to LIM and senescent cell antige...   180   2e-45
gi|170932518 paxillin isoform 3 [Homo sapiens]                        145   7e-35
gi|170932516 paxillin isoform 2 [Homo sapiens]                        145   7e-35
gi|170932514 paxillin isoform 1 [Homo sapiens]                        145   7e-35
gi|221316659 leupaxin isoform 1 [Homo sapiens]                        136   3e-32
gi|4758670 leupaxin isoform 2 [Homo sapiens]                          136   3e-32
gi|109638745 transforming growth factor beta 1 induced transcrip...   136   3e-32
gi|21361591 transforming growth factor beta 1 induced transcript...   136   3e-32
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]            131   1e-30
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]            131   1e-30
gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]             131   1e-30
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]             131   1e-30
gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]   119   6e-27
gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]   119   6e-27
gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]   119   6e-27
gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]   119   6e-27
gi|21361122 four and a half LIM domains 1 isoform 2 [Homo sapiens]    119   6e-27
gi|87159836 four and a half LIM domains 2 [Homo sapiens]              117   2e-26
gi|87159834 four and a half LIM domains 2 [Homo sapiens]              117   2e-26
gi|42403575 four and a half LIM domains 2 [Homo sapiens]              117   2e-26
gi|87159832 four and a half LIM domains 2 [Homo sapiens]              117   2e-26
gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens]      114   1e-25
gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens]      114   1e-25
gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens]      114   1e-25

>gi|40804748 LIM and senescent cell antigen-like domains 2 isoform 2
           [Homo sapiens]
          Length = 365

 Score =  797 bits (2058), Expect = 0.0
 Identities = 365/365 (100%), Positives = 365/365 (100%)

Query: 1   MAARLGALAASGLYRRRQHRQSPPPATGNMSDALANAVCQRCQARFSPAERIVNSNGELY 60
           MAARLGALAASGLYRRRQHRQSPPPATGNMSDALANAVCQRCQARFSPAERIVNSNGELY
Sbjct: 1   MAARLGALAASGLYRRRQHRQSPPPATGNMSDALANAVCQRCQARFSPAERIVNSNGELY 60

Query: 61  HEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWH 120
           HEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWH
Sbjct: 61  HEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWH 120

Query: 121 PGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRS 180
           PGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRS
Sbjct: 121 PGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPLMFRS 180

Query: 181 DAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQ 240
           DAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQ
Sbjct: 181 DAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNALGKQ 240

Query: 241 WHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAW 300
           WHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAW
Sbjct: 241 WHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAW 300

Query: 301 CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKAT 360
           CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKAT
Sbjct: 301 CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKAT 360

Query: 361 DLNSA 365
           DLNSA
Sbjct: 361 DLNSA 365


>gi|238859658 LIM and senescent cell antigen-like domains 2 isoform
           1 [Homo sapiens]
          Length = 363

 Score =  742 bits (1915), Expect = 0.0
 Identities = 337/337 (100%), Positives = 337/337 (100%)

Query: 29  NMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYC 88
           NMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYC
Sbjct: 27  NMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYC 86

Query: 89  EHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 148
           EHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR
Sbjct: 87  EHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 146

Query: 149 PCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL 208
           PCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL
Sbjct: 147 PCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL 206

Query: 209 YCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY 268
           YCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY
Sbjct: 207 YCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY 266

Query: 269 CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPV 328
           CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPV
Sbjct: 267 CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPV 326

Query: 329 CKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA 365
           CKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA
Sbjct: 327 CKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA 363


>gi|238776786 LIM and senescent cell antigen-like domains 2 isoform
           3 [Homo sapiens]
          Length = 341

 Score =  742 bits (1915), Expect = 0.0
 Identities = 337/337 (100%), Positives = 337/337 (100%)

Query: 29  NMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYC 88
           NMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYC
Sbjct: 5   NMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYC 64

Query: 89  EHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 148
           EHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR
Sbjct: 65  EHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 124

Query: 149 PCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL 208
           PCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL
Sbjct: 125 PCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL 184

Query: 209 YCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY 268
           YCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY
Sbjct: 185 YCLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY 244

Query: 269 CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPV 328
           CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPV
Sbjct: 245 CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPV 304

Query: 329 CKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA 365
           CKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA
Sbjct: 305 CKRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA 341


>gi|238776788 LIM and senescent cell antigen-like domains 2 isoform
           5 [Homo sapiens]
          Length = 336

 Score =  739 bits (1909), Expect = 0.0
 Identities = 336/336 (100%), Positives = 336/336 (100%)

Query: 30  MSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 89
           MSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE
Sbjct: 1   MSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 60

Query: 90  HDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 149
           HDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP
Sbjct: 61  HDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 120

Query: 150 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGELY 209
           CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGELY
Sbjct: 121 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGELY 180

Query: 210 CLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYC 269
           CLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYC
Sbjct: 181 CLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYC 240

Query: 270 ETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVC 329
           ETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVC
Sbjct: 241 ETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVC 300

Query: 330 KRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA 365
           KRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA
Sbjct: 301 KRCYEKFPLELKKRLKKLSELTSRKAQPKATDLNSA 336


>gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo
           sapiens]
          Length = 325

 Score =  639 bits (1648), Expect = 0.0
 Identities = 278/325 (85%), Positives = 307/325 (94%)

Query: 30  MSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 89
           M++ALA+A C+RC+  F+PAE+IVNSNGELYHE CFVCAQCF+ FPEGLFYEFEGRKYCE
Sbjct: 1   MANALASATCERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCE 60

Query: 90  HDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 149
           HDFQMLFAPCC  CGEFIIGRVIKAMNN+WHP CFRC+LC   LAD+GFVKNAGRHLCRP
Sbjct: 61  HDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRP 120

Query: 150 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGELY 209
           CHNREKA+GLGKYICQ+CH +IDEQPL+F++D YHPDHFNC +CGKELTA+ARELKGELY
Sbjct: 121 CHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADARELKGELY 180

Query: 210 CLPCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYC 269
           CLPCHDKMGVPICGACRRPIEGRVVNA+GKQWHVEHFVCAKCEKPFLGHRHYE+KGLAYC
Sbjct: 181 CLPCHDKMGVPICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYC 240

Query: 270 ETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVC 329
           ETHYNQLFGDVC++C+ VIEGDVVSALNKAWCV+CF+CSTCN+KLTLKNKFVEFDMKPVC
Sbjct: 241 ETHYNQLFGDVCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVC 300

Query: 330 KRCYEKFPLELKKRLKKLSELTSRK 354
           K+CYEKFPLELKKRLKKL+E   RK
Sbjct: 301 KKCYEKFPLELKKRLKKLAETLGRK 325


>gi|239741720 PREDICTED: hypothetical protein XP_002342298 [Homo
           sapiens]
          Length = 248

 Score =  320 bits (819), Expect = 2e-87
 Identities = 135/168 (80%), Positives = 153/168 (91%)

Query: 29  NMSDALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYC 88
           NM++ALA+A C+RC+  F+PAE IVNSNGELYHE CFVCAQCF+ FPEGLFYEFEGRKYC
Sbjct: 62  NMANALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYC 121

Query: 89  EHDFQMLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 148
           EHDFQMLFAPCC  CGEFIIGRVIKAMNN+WHP CFRC+LC   LAD+GFVKNAGRHLCR
Sbjct: 122 EHDFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCR 181

Query: 149 PCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKE 196
           PCHNREKA+GLGKYICQ+CH +IDEQPL+F++D YHPDHFNC +CG+E
Sbjct: 182 PCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGQE 229



 Score = 74.7 bits (182), Expect = 1e-13
 Identities = 35/103 (33%), Positives = 54/103 (52%), Gaps = 1/103 (0%)

Query: 233 VVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV 292
           +VN+ G+ +H + FVCA+C + F     YE +G  YCE  +  LF   C+ C   I G V
Sbjct: 85  IVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRV 144

Query: 293 VSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           + A+N +W   CF C  C   L     FV+   + +C+ C+ +
Sbjct: 145 IKAMNNSWHPECFRCDLCQEVLA-DIGFVKNAGRHLCRPCHNR 186



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 40/166 (24%), Positives = 62/166 (37%), Gaps = 8/166 (4%)

Query: 156 AKGLGKYICQRCH--LVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLP 212
           A  L    C+RC       E  +    + YH   F C  C ++       E +G  YC  
Sbjct: 64  ANALASATCERCKGGFAPAETIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEH 123

Query: 213 CHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 272
               +  P C  C   I GRV+ A+   WH E F C  C++        +  G   C   
Sbjct: 124 DFQMLFAPCCHQCGEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPC 183

Query: 273 YNQ-----LFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSK 313
           +N+     L   +C  C  +I+   +   N  +    F+C+ C  +
Sbjct: 184 HNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGQE 229



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 23/90 (25%), Positives = 36/90 (40%), Gaps = 5/90 (5%)

Query: 51  RIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE--HDFQM---LFAPCCGSCGE 105
           R++ +    +H  CF C  C     +  F +  GR  C   H+ +    L    C  C  
Sbjct: 143 RVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHA 202

Query: 106 FIIGRVIKAMNNNWHPGCFRCELCDVELAD 135
            I  + +   N+ +HP  F C  C  E +D
Sbjct: 203 IIDEQPLIFKNDPYHPDHFNCANCGQEGSD 232


>gi|239758027 PREDICTED: similar to LIM and senescent cell
           antigen-like domains 1 [Homo sapiens]
          Length = 116

 Score =  180 bits (456), Expect = 2e-45
 Identities = 74/91 (81%), Positives = 84/91 (92%)

Query: 104 GEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYI 163
           GEFIIGRVIKAMNN+WHP CFRC+LC   LAD+GFVKNAGRHLCRPCHNREKA+GLGKYI
Sbjct: 26  GEFIIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYI 85

Query: 164 CQRCHLVIDEQPLMFRSDAYHPDHFNCTHCG 194
           CQ+CH +IDEQPL+F++D YHPDHFNC +CG
Sbjct: 86  CQKCHAIIDEQPLIFKNDPYHPDHFNCANCG 116



 Score = 45.8 bits (107), Expect = 6e-05
 Identities = 30/110 (27%), Positives = 52/110 (47%), Gaps = 16/110 (14%)

Query: 149 PCHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELK--G 206
           P    ++ K LG++I  R         +   ++++HP+ F C  C +E+ A+   +K  G
Sbjct: 15  PLPGFQRLKKLGEFIIGRV--------IKAMNNSWHPECFRCDLC-QEVLADIGFVKNAG 65

Query: 207 ELYCLPCHDK-----MGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKC 251
              C PCH++     +G  IC  C   I+ + +      +H +HF CA C
Sbjct: 66  RHLCRPCHNREKARGLGKYICQKCHAIIDEQPLIFKNDPYHPDHFNCANC 115



 Score = 38.9 bits (89), Expect = 0.007
 Identities = 22/87 (25%), Positives = 36/87 (41%), Gaps = 5/87 (5%)

Query: 229 IEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQ-----LFGDVCYN 283
           I GRV+ A+   WH E F C  C++        +  G   C   +N+     L   +C  
Sbjct: 29  IIGRVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQK 88

Query: 284 CSHVIEGDVVSALNKAWCVSCFSCSTC 310
           C  +I+   +   N  +    F+C+ C
Sbjct: 89  CHAIIDEQPLIFKNDPYHPDHFNCANC 115



 Score = 32.3 bits (72), Expect = 0.69
 Identities = 15/48 (31%), Positives = 24/48 (50%), Gaps = 1/48 (2%)

Query: 288 IEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           I G V+ A+N +W   CF C  C   L     FV+   + +C+ C+ +
Sbjct: 29  IIGRVIKAMNNSWHPECFRCDLCQEVLA-DIGFVKNAGRHLCRPCHNR 75



 Score = 32.3 bits (72), Expect = 0.69
 Identities = 21/84 (25%), Positives = 33/84 (39%), Gaps = 5/84 (5%)

Query: 51  RIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE--HDFQM---LFAPCCGSCGE 105
           R++ +    +H  CF C  C     +  F +  GR  C   H+ +    L    C  C  
Sbjct: 32  RVIKAMNNSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHA 91

Query: 106 FIIGRVIKAMNNNWHPGCFRCELC 129
            I  + +   N+ +HP  F C  C
Sbjct: 92  IIDEQPLIFKNDPYHPDHFNCANC 115


>gi|170932518 paxillin isoform 3 [Homo sapiens]
          Length = 424

 Score =  145 bits (365), Expect = 7e-35
 Identities = 79/238 (33%), Positives = 113/238 (47%), Gaps = 9/238 (3%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLC-RPCHNREKAKG 158
           CG+C + I G+V+ AM   WHP  F C  C  E+    F +  G+  C +  HN    + 
Sbjct: 191 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR- 249

Query: 159 LGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKM 217
                C  C+  I ++ +      +HP+HF C  CG     E   E  G+ YC   +  M
Sbjct: 250 -----CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDM 304

Query: 218 GVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLF 277
             P CG C R I    ++AL   WH E FVC +C  PF+    +E  G  YCE HY++  
Sbjct: 305 FAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERR 364

Query: 278 GDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           G +C  C   I G  ++A+ K +    F C+ C  +L  K  F E + KP C+ C+ K
Sbjct: 365 GSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLN-KGTFKEQNDKPYCQNCFLK 421



 Score =  129 bits (325), Expect = 3e-30
 Identities = 76/246 (30%), Positives = 116/246 (47%), Gaps = 10/246 (4%)

Query: 34  LANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQ 93
           +A  VC  C+     A ++V + G+ +H   FVC  C        F+E +G+ YCE D+ 
Sbjct: 186 VAKGVCGACKKPI--AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYH 243

Query: 94  MLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNR 153
            LF+P C  C   I+ +V+ A++  WHP  F C  C       GF +  G+  CR  +  
Sbjct: 244 NLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFD 303

Query: 154 EKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKE-LTAEARELKGELYC-L 211
             A       C  C   I E  +   +  +HP+ F C  C    +     E  G+ YC +
Sbjct: 304 MFAPK-----CGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEV 358

Query: 212 PCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCET 271
             H++ G  +C  C++PI GR + A+ K++H EHFVCA C K        E+    YC+ 
Sbjct: 359 HYHERRG-SLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQN 417

Query: 272 HYNQLF 277
            + +LF
Sbjct: 418 CFLKLF 423



 Score =  118 bits (295), Expect = 1e-26
 Identities = 62/178 (34%), Positives = 86/178 (48%), Gaps = 2/178 (1%)

Query: 159 LGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKEL-TAEARELKGELYCLPCHDKM 217
           + K +C  C   I  Q +      +HP+HF CTHC +E+ +    E  G+ YC   +  +
Sbjct: 186 VAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 245

Query: 218 GVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLF 277
             P C  C  PI  +VV AL + WH EHF CA+C   F     +EK G AYC   Y  +F
Sbjct: 246 FSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMF 305

Query: 278 GDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
              C  C+  I  + +SALN  W   CF C  C +   +   F E D +P C+  Y +
Sbjct: 306 APKCGGCARAILENYISALNTLWHPECFVCRECFTPF-VNGSFFEHDGQPYCEVHYHE 362



 Score =  101 bits (251), Expect = 1e-21
 Identities = 53/145 (36%), Positives = 78/145 (53%), Gaps = 12/145 (8%)

Query: 194 GKELTAEARELKGELYCLPCHDKMGVP-----ICGACRRPIEGRVVNALGKQWHVEHFVC 248
           G +L +    L+ +L      +K+GV      +CGAC++PI G+VV A+GK WH EHFVC
Sbjct: 164 GSQLDSMLGSLQSDL------NKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVC 217

Query: 249 AKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCS 308
             C++       +E+ G  YCE  Y+ LF   CY C+  I   VV+AL++ W    F C+
Sbjct: 218 THCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCA 277

Query: 309 TCNSKLTLKNKFVEFDMKPVCKRCY 333
            C +    +  F E D K  C++ Y
Sbjct: 278 QCGAFFGPEG-FHEKDGKAYCRKDY 301


>gi|170932516 paxillin isoform 2 [Homo sapiens]
          Length = 557

 Score =  145 bits (365), Expect = 7e-35
 Identities = 79/238 (33%), Positives = 113/238 (47%), Gaps = 9/238 (3%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLC-RPCHNREKAKG 158
           CG+C + I G+V+ AM   WHP  F C  C  E+    F +  G+  C +  HN    + 
Sbjct: 324 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR- 382

Query: 159 LGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKM 217
                C  C+  I ++ +      +HP+HF C  CG     E   E  G+ YC   +  M
Sbjct: 383 -----CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDM 437

Query: 218 GVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLF 277
             P CG C R I    ++AL   WH E FVC +C  PF+    +E  G  YCE HY++  
Sbjct: 438 FAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERR 497

Query: 278 GDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           G +C  C   I G  ++A+ K +    F C+ C  +L  K  F E + KP C+ C+ K
Sbjct: 498 GSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLN-KGTFKEQNDKPYCQNCFLK 554



 Score =  129 bits (325), Expect = 3e-30
 Identities = 76/246 (30%), Positives = 116/246 (47%), Gaps = 10/246 (4%)

Query: 34  LANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQ 93
           +A  VC  C+     A ++V + G+ +H   FVC  C        F+E +G+ YCE D+ 
Sbjct: 319 VAKGVCGACKKPI--AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYH 376

Query: 94  MLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNR 153
            LF+P C  C   I+ +V+ A++  WHP  F C  C       GF +  G+  CR  +  
Sbjct: 377 NLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFD 436

Query: 154 EKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKE-LTAEARELKGELYC-L 211
             A       C  C   I E  +   +  +HP+ F C  C    +     E  G+ YC +
Sbjct: 437 MFAPK-----CGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEV 491

Query: 212 PCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCET 271
             H++ G  +C  C++PI GR + A+ K++H EHFVCA C K        E+    YC+ 
Sbjct: 492 HYHERRG-SLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQN 550

Query: 272 HYNQLF 277
            + +LF
Sbjct: 551 CFLKLF 556



 Score =  118 bits (295), Expect = 1e-26
 Identities = 62/178 (34%), Positives = 86/178 (48%), Gaps = 2/178 (1%)

Query: 159 LGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKEL-TAEARELKGELYCLPCHDKM 217
           + K +C  C   I  Q +      +HP+HF CTHC +E+ +    E  G+ YC   +  +
Sbjct: 319 VAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 378

Query: 218 GVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLF 277
             P C  C  PI  +VV AL + WH EHF CA+C   F     +EK G AYC   Y  +F
Sbjct: 379 FSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMF 438

Query: 278 GDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
              C  C+  I  + +SALN  W   CF C  C +   +   F E D +P C+  Y +
Sbjct: 439 APKCGGCARAILENYISALNTLWHPECFVCRECFTPF-VNGSFFEHDGQPYCEVHYHE 495



 Score =  101 bits (251), Expect = 1e-21
 Identities = 53/145 (36%), Positives = 78/145 (53%), Gaps = 12/145 (8%)

Query: 194 GKELTAEARELKGELYCLPCHDKMGVP-----ICGACRRPIEGRVVNALGKQWHVEHFVC 248
           G +L +    L+ +L      +K+GV      +CGAC++PI G+VV A+GK WH EHFVC
Sbjct: 297 GSQLDSMLGSLQSDL------NKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVC 350

Query: 249 AKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCS 308
             C++       +E+ G  YCE  Y+ LF   CY C+  I   VV+AL++ W    F C+
Sbjct: 351 THCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCA 410

Query: 309 TCNSKLTLKNKFVEFDMKPVCKRCY 333
            C +    +  F E D K  C++ Y
Sbjct: 411 QCGAFFGPEG-FHEKDGKAYCRKDY 434


>gi|170932514 paxillin isoform 1 [Homo sapiens]
          Length = 591

 Score =  145 bits (365), Expect = 7e-35
 Identities = 79/238 (33%), Positives = 113/238 (47%), Gaps = 9/238 (3%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLC-RPCHNREKAKG 158
           CG+C + I G+V+ AM   WHP  F C  C  E+    F +  G+  C +  HN    + 
Sbjct: 358 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR- 416

Query: 159 LGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKM 217
                C  C+  I ++ +      +HP+HF C  CG     E   E  G+ YC   +  M
Sbjct: 417 -----CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDM 471

Query: 218 GVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLF 277
             P CG C R I    ++AL   WH E FVC +C  PF+    +E  G  YCE HY++  
Sbjct: 472 FAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERR 531

Query: 278 GDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           G +C  C   I G  ++A+ K +    F C+ C  +L  K  F E + KP C+ C+ K
Sbjct: 532 GSLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLN-KGTFKEQNDKPYCQNCFLK 588



 Score =  129 bits (325), Expect = 3e-30
 Identities = 76/246 (30%), Positives = 116/246 (47%), Gaps = 10/246 (4%)

Query: 34  LANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQ 93
           +A  VC  C+     A ++V + G+ +H   FVC  C        F+E +G+ YCE D+ 
Sbjct: 353 VAKGVCGACKKPI--AGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYH 410

Query: 94  MLFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNR 153
            LF+P C  C   I+ +V+ A++  WHP  F C  C       GF +  G+  CR  +  
Sbjct: 411 NLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFD 470

Query: 154 EKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKE-LTAEARELKGELYC-L 211
             A       C  C   I E  +   +  +HP+ F C  C    +     E  G+ YC +
Sbjct: 471 MFAPK-----CGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEV 525

Query: 212 PCHDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCET 271
             H++ G  +C  C++PI GR + A+ K++H EHFVCA C K        E+    YC+ 
Sbjct: 526 HYHERRG-SLCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQN 584

Query: 272 HYNQLF 277
            + +LF
Sbjct: 585 CFLKLF 590



 Score =  118 bits (295), Expect = 1e-26
 Identities = 62/178 (34%), Positives = 86/178 (48%), Gaps = 2/178 (1%)

Query: 159 LGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKEL-TAEARELKGELYCLPCHDKM 217
           + K +C  C   I  Q +      +HP+HF CTHC +E+ +    E  G+ YC   +  +
Sbjct: 353 VAKGVCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNL 412

Query: 218 GVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLF 277
             P C  C  PI  +VV AL + WH EHF CA+C   F     +EK G AYC   Y  +F
Sbjct: 413 FSPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMF 472

Query: 278 GDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
              C  C+  I  + +SALN  W   CF C  C +   +   F E D +P C+  Y +
Sbjct: 473 APKCGGCARAILENYISALNTLWHPECFVCRECFTPF-VNGSFFEHDGQPYCEVHYHE 529



 Score =  101 bits (251), Expect = 1e-21
 Identities = 53/145 (36%), Positives = 78/145 (53%), Gaps = 12/145 (8%)

Query: 194 GKELTAEARELKGELYCLPCHDKMGVP-----ICGACRRPIEGRVVNALGKQWHVEHFVC 248
           G +L +    L+ +L      +K+GV      +CGAC++PI G+VV A+GK WH EHFVC
Sbjct: 331 GSQLDSMLGSLQSDL------NKLGVATVAKGVCGACKKPIAGQVVTAMGKTWHPEHFVC 384

Query: 249 AKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCS 308
             C++       +E+ G  YCE  Y+ LF   CY C+  I   VV+AL++ W    F C+
Sbjct: 385 THCQEEIGSRNFFERDGQPYCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFCA 444

Query: 309 TCNSKLTLKNKFVEFDMKPVCKRCY 333
            C +    +  F E D K  C++ Y
Sbjct: 445 QCGAFFGPEG-FHEKDGKAYCRKDY 468


>gi|221316659 leupaxin isoform 1 [Homo sapiens]
          Length = 391

 Score =  136 bits (343), Expect = 3e-32
 Identities = 79/241 (32%), Positives = 116/241 (48%), Gaps = 8/241 (3%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 159
           C SC + I G+VI A+  +WHP  F C  C  E+    F + +G   C   +++     L
Sbjct: 157 CASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQ-----L 211

Query: 160 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKMG 218
               C  C   I ++ L   +  +HP+HF C+HCG+   AE   E   + YC      M 
Sbjct: 212 FSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMF 271

Query: 219 VPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 278
            P CG C RP+    ++A+   WH E FVC  C   F     +E  G  +CE HY+   G
Sbjct: 272 SPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRG 331

Query: 279 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK-FP 337
            +C+ C   I G  +SA+   +    F C+ C ++L+ K  F E + K  C+ C+ K FP
Sbjct: 332 TLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLS-KGIFREQNDKTYCQPCFNKLFP 390

Query: 338 L 338
           L
Sbjct: 391 L 391



 Score =  128 bits (322), Expect = 7e-30
 Identities = 84/290 (28%), Positives = 127/290 (43%), Gaps = 21/290 (7%)

Query: 1   MAARLGALAASG---LYRRRQHRQSPPPATGNMSDALAN--------AVCQRCQARFSPA 49
           M A++   A +G   L  ++ H+ S     G +   L +          C  CQ     A
Sbjct: 108 MQAKVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPI--A 165

Query: 50  ERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIG 109
            +++++ G+ +H   FVC  C        F+E  G  YC +D+  LF+P C  C   I+ 
Sbjct: 166 GKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILD 225

Query: 110 RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHL 169
           +V+ AMN  WHP  F C  C       GF +   +  C     R+    +    C  C+ 
Sbjct: 226 KVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYC-----RKDFLAMFSPKCGGCNR 280

Query: 170 VIDEQPLMFRSDAYHPDHFNCTHCGKEL-TAEARELKGELYC-LPCHDKMGVPICGACRR 227
            + E  L      +HP+ F C  C     T    EL G  +C L  H + G  +C  C +
Sbjct: 281 PVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT-LCHGCGQ 339

Query: 228 PIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLF 277
           PI GR ++A+G ++H EHFVCA C          E+    YC+  +N+LF
Sbjct: 340 PITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 389


>gi|4758670 leupaxin isoform 2 [Homo sapiens]
          Length = 386

 Score =  136 bits (343), Expect = 3e-32
 Identities = 79/241 (32%), Positives = 116/241 (48%), Gaps = 8/241 (3%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 159
           C SC + I G+VI A+  +WHP  F C  C  E+    F + +G   C   +++     L
Sbjct: 152 CASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQ-----L 206

Query: 160 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKMG 218
               C  C   I ++ L   +  +HP+HF C+HCG+   AE   E   + YC      M 
Sbjct: 207 FSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMF 266

Query: 219 VPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 278
            P CG C RP+    ++A+   WH E FVC  C   F     +E  G  +CE HY+   G
Sbjct: 267 SPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRG 326

Query: 279 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK-FP 337
            +C+ C   I G  +SA+   +    F C+ C ++L+ K  F E + K  C+ C+ K FP
Sbjct: 327 TLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLS-KGIFREQNDKTYCQPCFNKLFP 385

Query: 338 L 338
           L
Sbjct: 386 L 386



 Score =  128 bits (322), Expect = 7e-30
 Identities = 84/290 (28%), Positives = 127/290 (43%), Gaps = 21/290 (7%)

Query: 1   MAARLGALAASG---LYRRRQHRQSPPPATGNMSDALAN--------AVCQRCQARFSPA 49
           M A++   A +G   L  ++ H+ S     G +   L +          C  CQ     A
Sbjct: 103 MQAKVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPI--A 160

Query: 50  ERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIG 109
            +++++ G+ +H   FVC  C        F+E  G  YC +D+  LF+P C  C   I+ 
Sbjct: 161 GKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILD 220

Query: 110 RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHL 169
           +V+ AMN  WHP  F C  C       GF +   +  C     R+    +    C  C+ 
Sbjct: 221 KVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYC-----RKDFLAMFSPKCGGCNR 275

Query: 170 VIDEQPLMFRSDAYHPDHFNCTHCGKEL-TAEARELKGELYC-LPCHDKMGVPICGACRR 227
            + E  L      +HP+ F C  C     T    EL G  +C L  H + G  +C  C +
Sbjct: 276 PVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT-LCHGCGQ 334

Query: 228 PIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLF 277
           PI GR ++A+G ++H EHFVCA C          E+    YC+  +N+LF
Sbjct: 335 PITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 384


>gi|109638745 transforming growth factor beta 1 induced transcript 1
           isoform 1 [Homo sapiens]
          Length = 461

 Score =  136 bits (343), Expect = 3e-32
 Identities = 76/237 (32%), Positives = 109/237 (45%), Gaps = 7/237 (2%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 159
           CGSC + I G+V+ A+   WHP  F C  C   L    F +  G   C  C+    +   
Sbjct: 228 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR- 286

Query: 160 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKMG 218
               C  C+  I  + +      +HP+HF C  CG+    E   E +G  YC     ++ 
Sbjct: 287 ----CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLF 342

Query: 219 VPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 278
            P C  C+ PI    ++AL   WH + FVC +C  PF G   +E +G   CE H++   G
Sbjct: 343 APRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRG 402

Query: 279 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
            +C  C   + G  VSAL + +    F+C+ C   LT K  F E   KP C+ C+ K
Sbjct: 403 SLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLT-KGSFQERAGKPYCQPCFLK 458



 Score =  120 bits (302), Expect = 1e-27
 Identities = 72/245 (29%), Positives = 107/245 (43%), Gaps = 8/245 (3%)

Query: 35  ANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQM 94
           A  +C  C      A ++V + G  +H   FVC  C        F+E +G  +C   +  
Sbjct: 224 AKGLCGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFE 281

Query: 95  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNRE 154
            F+P CG C + I  +++ A+  +WHP  F C  C     D GF +  GR  C     R 
Sbjct: 282 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC-----RR 336

Query: 155 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPC 213
               L    CQ C   I +  +   S  +HPD F C  C    +  +  E +G   C   
Sbjct: 337 DFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 396

Query: 214 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 273
                  +C  C  P+ GR V+ALG+++H +HF C  C +P       E+ G  YC+  +
Sbjct: 397 FHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 456

Query: 274 NQLFG 278
            +LFG
Sbjct: 457 LKLFG 461



 Score =  115 bits (288), Expect = 6e-26
 Identities = 61/177 (34%), Positives = 87/177 (49%), Gaps = 6/177 (3%)

Query: 155 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPC 213
           +AKGL    C  C+  I  Q +     A+HP+HF C  C   L   +  E  G  +C  C
Sbjct: 223 QAKGL----CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPEC 278

Query: 214 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 273
           + +   P CG C +PI  ++V ALG  WH EHF C  C +PF     +E++G  YC   +
Sbjct: 279 YFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDF 338

Query: 274 NQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 330
            QLF   C  C   I  + +SAL+  W   CF C  C +  +    F E + +P+C+
Sbjct: 339 LQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFS-GGSFFEHEGRPLCE 394


>gi|21361591 transforming growth factor beta 1 induced transcript 1
           isoform 2 [Homo sapiens]
          Length = 444

 Score =  136 bits (343), Expect = 3e-32
 Identities = 76/237 (32%), Positives = 109/237 (45%), Gaps = 7/237 (2%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 159
           CGSC + I G+V+ A+   WHP  F C  C   L    F +  G   C  C+    +   
Sbjct: 211 CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFERFSPR- 269

Query: 160 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPCHDKMG 218
               C  C+  I  + +      +HP+HF C  CG+    E   E +G  YC     ++ 
Sbjct: 270 ----CGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLF 325

Query: 219 VPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFG 278
            P C  C+ PI    ++AL   WH + FVC +C  PF G   +E +G   CE H++   G
Sbjct: 326 APRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRG 385

Query: 279 DVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
            +C  C   + G  VSAL + +    F+C+ C   LT K  F E   KP C+ C+ K
Sbjct: 386 SLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLT-KGSFQERAGKPYCQPCFLK 441



 Score =  120 bits (302), Expect = 1e-27
 Identities = 72/245 (29%), Positives = 107/245 (43%), Gaps = 8/245 (3%)

Query: 35  ANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQM 94
           A  +C  C      A ++V + G  +H   FVC  C        F+E +G  +C   +  
Sbjct: 207 AKGLCGSCNKPI--AGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPECYFE 264

Query: 95  LFAPCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNRE 154
            F+P CG C + I  +++ A+  +WHP  F C  C     D GF +  GR  C     R 
Sbjct: 265 RFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYC-----RR 319

Query: 155 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGELYCLPC 213
               L    CQ C   I +  +   S  +HPD F C  C    +  +  E +G   C   
Sbjct: 320 DFLQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENH 379

Query: 214 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 273
                  +C  C  P+ GR V+ALG+++H +HF C  C +P       E+ G  YC+  +
Sbjct: 380 FHARRGSLCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCF 439

Query: 274 NQLFG 278
            +LFG
Sbjct: 440 LKLFG 444



 Score =  115 bits (288), Expect = 6e-26
 Identities = 61/177 (34%), Positives = 87/177 (49%), Gaps = 6/177 (3%)

Query: 155 KAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPC 213
           +AKGL    C  C+  I  Q +     A+HP+HF C  C   L   +  E  G  +C  C
Sbjct: 206 QAKGL----CGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTALGGSSFFEKDGAPFCPEC 261

Query: 214 HDKMGVPICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHY 273
           + +   P CG C +PI  ++V ALG  WH EHF C  C +PF     +E++G  YC   +
Sbjct: 262 YFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDF 321

Query: 274 NQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 330
            QLF   C  C   I  + +SAL+  W   CF C  C +  +    F E + +P+C+
Sbjct: 322 LQLFAPRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFS-GGSFFEHEGRPLCE 377


>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
          Length = 487

 Score =  131 bits (329), Expect = 1e-30
 Identities = 69/172 (40%), Positives = 94/172 (54%), Gaps = 4/172 (2%)

Query: 163 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 221
           +C  C+ VI    L+    ++HP+ FNC HC   +      E KG LYC  C++K   P 
Sbjct: 310 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 369

Query: 222 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 281
           CG C+R I G V++AL + WHV  FVC  C KP   +  + + G  YCET Y  LFG +C
Sbjct: 370 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 429

Query: 282 YNCSHVIE-GDV-VSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKR 331
           + C   IE GD+ + AL   W  +CF CS C   L  +  F + D KP+CK+
Sbjct: 430 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKD-KPLCKK 480



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 55/178 (30%), Positives = 76/178 (42%), Gaps = 8/178 (4%)

Query: 98  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157
           P C  C + I G  + A+  +WHP  F C  C   +A +GFV+  G   C  C+ +  A 
Sbjct: 309 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 368

Query: 158 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDK 216
                 C RC   I  + +      +H   F C  CGK +      L+ GE YC   +  
Sbjct: 369 E-----CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYA 423

Query: 217 MGVPICGACRRPIEG--RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 272
           +   IC  C  PIE     + ALG  WH   FVC+ C +   G   + KK    C+ H
Sbjct: 424 LFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 481



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 1/114 (0%)

Query: 220 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 279
           P+C  C + I G  + ALGK WH E F CA C+         E+KG  YCE  Y + F  
Sbjct: 309 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 368

Query: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCY 333
            C  C   I G+V+SAL + W VSCF C  C   +   N F   D +P C+  Y
Sbjct: 369 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIR-NNVFHLEDGEPYCETDY 421



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 6/113 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C RCQ +      ++++  + +H  CFVC  C +P    +F+  +G  YCE D+  LF  
Sbjct: 370 CGRCQRKI--LGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 427

Query: 99  CCGSCGEFII---GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 148
            C  C EF I      ++A+   WH  CF C +C   L    F     + LC+
Sbjct: 428 ICHGC-EFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 479



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 43/146 (29%), Positives = 59/146 (40%), Gaps = 7/146 (4%)

Query: 57  GELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMN 116
           G+ +H   F CA C        F E +G  YCE  ++  FAP CG C   I+G VI A+ 
Sbjct: 327 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 386

Query: 117 NNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPL 176
             WH  CF C  C   + +  F    G   C   +       L   IC  C   I+   +
Sbjct: 387 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY-----YALFGTICHGCEFPIEAGDM 441

Query: 177 MFRSDAY--HPDHFNCTHCGKELTAE 200
              +  Y  H   F C+ C + L  +
Sbjct: 442 FLEALGYTWHDTCFVCSVCCESLEGQ 467



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)

Query: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKF 336
           +C +C+ VI G  + AL K+W    F+C+ C + +     FVE      C+ CYEKF
Sbjct: 310 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIG-FVEEKGALYCELCYEKF 365



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 13/57 (22%), Positives = 25/57 (43%)

Query: 33  ALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 89
           AL   +C  C+      +  + + G  +H+ CFVC+ C        F+  + +  C+
Sbjct: 423 ALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 479


>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
          Length = 596

 Score =  131 bits (329), Expect = 1e-30
 Identities = 69/172 (40%), Positives = 94/172 (54%), Gaps = 4/172 (2%)

Query: 163 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 221
           +C  C+ VI    L+    ++HP+ FNC HC   +      E KG LYC  C++K   P 
Sbjct: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPE 478

Query: 222 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 281
           CG C+R I G V++AL + WHV  FVC  C KP   +  + + G  YCET Y  LFG +C
Sbjct: 479 CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTIC 538

Query: 282 YNCSHVIE-GDV-VSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKR 331
           + C   IE GD+ + AL   W  +CF CS C   L  +  F + D KP+CK+
Sbjct: 539 HGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKD-KPLCKK 589



 Score = 91.7 bits (226), Expect = 1e-18
 Identities = 55/178 (30%), Positives = 76/178 (42%), Gaps = 8/178 (4%)

Query: 98  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157
           P C  C + I G  + A+  +WHP  F C  C   +A +GFV+  G   C  C+ +  A 
Sbjct: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477

Query: 158 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDK 216
                 C RC   I  + +      +H   F C  CGK +      L+ GE YC   +  
Sbjct: 478 E-----CGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYA 532

Query: 217 MGVPICGACRRPIEG--RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 272
           +   IC  C  PIE     + ALG  WH   FVC+ C +   G   + KK    C+ H
Sbjct: 533 LFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKH 590



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 1/114 (0%)

Query: 220 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 279
           P+C  C + I G  + ALGK WH E F CA C+         E+KG  YCE  Y + F  
Sbjct: 418 PMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAP 477

Query: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCY 333
            C  C   I G+V+SAL + W VSCF C  C   +   N F   D +P C+  Y
Sbjct: 478 ECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIR-NNVFHLEDGEPYCETDY 530



 Score = 70.1 bits (170), Expect = 3e-12
 Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 6/113 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C RCQ +      ++++  + +H  CFVC  C +P    +F+  +G  YCE D+  LF  
Sbjct: 479 CGRCQRKI--LGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGT 536

Query: 99  CCGSCGEFII---GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCR 148
            C  C EF I      ++A+   WH  CF C +C   L    F     + LC+
Sbjct: 537 ICHGC-EFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588



 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 43/146 (29%), Positives = 59/146 (40%), Gaps = 7/146 (4%)

Query: 57  GELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMN 116
           G+ +H   F CA C        F E +G  YCE  ++  FAP CG C   I+G VI A+ 
Sbjct: 436 GKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEVISALK 495

Query: 117 NNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVIDEQPL 176
             WH  CF C  C   + +  F    G   C   +       L   IC  C   I+   +
Sbjct: 496 QTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDY-----YALFGTICHGCEFPIEAGDM 550

Query: 177 MFRSDAY--HPDHFNCTHCGKELTAE 200
              +  Y  H   F C+ C + L  +
Sbjct: 551 FLEALGYTWHDTCFVCSVCCESLEGQ 576



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)

Query: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKF 336
           +C +C+ VI G  + AL K+W    F+C+ C + +     FVE      C+ CYEKF
Sbjct: 419 MCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIG-FVEEKGALYCELCYEKF 474



 Score = 34.7 bits (78), Expect = 0.14
 Identities = 13/57 (22%), Positives = 25/57 (43%)

Query: 33  ALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 89
           AL   +C  C+      +  + + G  +H+ CFVC+ C        F+  + +  C+
Sbjct: 532 ALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCK 588


>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
          Length = 423

 Score =  131 bits (329), Expect = 1e-30
 Identities = 64/171 (37%), Positives = 94/171 (54%), Gaps = 4/171 (2%)

Query: 163 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 221
           +C +CH VI  + L+    AYHP+ F C+ CGK L      E KG ++C PC+D    P 
Sbjct: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306

Query: 222 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 281
           C  C++ I G +++AL   WHV  F CA C+ P      Y ++G+ YCE  Y ++FG  C
Sbjct: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366

Query: 282 YNCSHVIE-GD-VVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 330
           + C   I+ GD  + AL  +W  +CF C+ C   L  K  + + D +P+CK
Sbjct: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKD-RPLCK 416



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 40/116 (34%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 220 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 279
           P+C  C + I GR + ALG  +H E FVC++C K       +E+KG  +C   Y+  +  
Sbjct: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305

Query: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
            C  C   I G+++ AL   W V CF+C+ C + +  +  ++E +  P C+R YEK
Sbjct: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYME-EGVPYCERDYEK 360



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 8/178 (4%)

Query: 98  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157
           P C  C + I GR + A+ + +HP  F C  C   L + GF +  G   C PC++   A 
Sbjct: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305

Query: 158 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAREL-KGELYCLPCHDK 216
                 C +C   I  + +      +H   F C  C   +   A  + +G  YC   ++K
Sbjct: 306 S-----CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEK 360

Query: 217 MGVPICGACRRPIEG--RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 272
           M    C  C   I+   R + ALG  WH   FVCA C+    G   Y KK    C++H
Sbjct: 361 MFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 418



 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 46/158 (29%), Positives = 68/158 (43%), Gaps = 9/158 (5%)

Query: 38  VCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFA 97
           VC +C        R + + G  YH   FVC+QC +   EG F+E +G  +C   + + +A
Sbjct: 247 VCHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304

Query: 98  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157
           P C  C + I G ++ A+   WH  CF C  C   + +  F    G   C     R+  K
Sbjct: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYC----ERDYEK 360

Query: 158 GLGKYICQRCHLVID--EQPLMFRSDAYHPDHFNCTHC 193
             G   C  C   ID  ++ L     ++H   F C  C
Sbjct: 361 MFGTK-CHGCDFKIDAGDRFLEALGFSWHDTCFVCAIC 397



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 89
           C  C  +    +R + + G  +H+ CFVCA C        FY  + R  C+
Sbjct: 366 CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416


>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
          Length = 457

 Score =  131 bits (329), Expect = 1e-30
 Identities = 64/171 (37%), Positives = 94/171 (54%), Gaps = 4/171 (2%)

Query: 163 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 221
           +C +CH VI  + L+    AYHP+ F C+ CGK L      E KG ++C PC+D    P 
Sbjct: 281 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 340

Query: 222 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 281
           C  C++ I G +++AL   WHV  F CA C+ P      Y ++G+ YCE  Y ++FG  C
Sbjct: 341 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 400

Query: 282 YNCSHVIE-GD-VVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 330
           + C   I+ GD  + AL  +W  +CF C+ C   L  K  + + D +P+CK
Sbjct: 401 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKD-RPLCK 450



 Score = 87.8 bits (216), Expect = 1e-17
 Identities = 40/116 (34%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 220 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 279
           P+C  C + I GR + ALG  +H E FVC++C K       +E+KG  +C   Y+  +  
Sbjct: 280 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 339

Query: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
            C  C   I G+++ AL   W V CF+C+ C + +  +  ++E +  P C+R YEK
Sbjct: 340 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYME-EGVPYCERDYEK 394



 Score = 82.4 bits (202), Expect = 6e-16
 Identities = 53/178 (29%), Positives = 76/178 (42%), Gaps = 8/178 (4%)

Query: 98  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157
           P C  C + I GR + A+ + +HP  F C  C   L + GF +  G   C PC++   A 
Sbjct: 280 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 339

Query: 158 GLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAREL-KGELYCLPCHDK 216
                 C +C   I  + +      +H   F C  C   +   A  + +G  YC   ++K
Sbjct: 340 S-----CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEK 394

Query: 217 MGVPICGACRRPIEG--RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETH 272
           M    C  C   I+   R + ALG  WH   FVCA C+    G   Y KK    C++H
Sbjct: 395 MFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 452



 Score = 75.9 bits (185), Expect = 5e-14
 Identities = 46/158 (29%), Positives = 68/158 (43%), Gaps = 9/158 (5%)

Query: 38  VCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFA 97
           VC +C        R + + G  YH   FVC+QC +   EG F+E +G  +C   + + +A
Sbjct: 281 VCHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 338

Query: 98  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157
           P C  C + I G ++ A+   WH  CF C  C   + +  F    G   C     R+  K
Sbjct: 339 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYC----ERDYEK 394

Query: 158 GLGKYICQRCHLVID--EQPLMFRSDAYHPDHFNCTHC 193
             G   C  C   ID  ++ L     ++H   F C  C
Sbjct: 395 MFGTK-CHGCDFKIDAGDRFLEALGFSWHDTCFVCAIC 431



 Score = 35.0 bits (79), Expect = 0.11
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 89
           C  C  +    +R + + G  +H+ CFVCA C        FY  + R  C+
Sbjct: 400 CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 450


>gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  119 bits (297), Expect = 6e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 179
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 118

Query: 180 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 238
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 119 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 178

Query: 239 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 293
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 179 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 238

Query: 294 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 239 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 279



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 32  DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 91
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 33  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 92

Query: 92  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 149
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 93  TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 152

Query: 150 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 208
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 153 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 207

Query: 209 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 263
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 208 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 267

Query: 264 KGLAYC 269
           +   YC
Sbjct: 268 QEQVYC 273



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 101 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 160

Query: 99  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 158
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 161 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 220

Query: 159 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 212
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 221 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 275

Query: 213 CHDKM 217
           C  K+
Sbjct: 276 CAKKL 280


>gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  119 bits (297), Expect = 6e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 179
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 118

Query: 180 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 238
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 119 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 178

Query: 239 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 293
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 179 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 238

Query: 294 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 239 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 279



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 32  DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 91
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 33  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 92

Query: 92  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 149
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 93  TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 152

Query: 150 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 208
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 153 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 207

Query: 209 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 263
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 208 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 267

Query: 264 KGLAYC 269
           +   YC
Sbjct: 268 QEQVYC 273



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 101 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 160

Query: 99  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 158
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 161 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 220

Query: 159 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 212
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 221 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 275

Query: 213 CHDKM 217
           C  K+
Sbjct: 276 CAKKL 280


>gi|228480209 four and a half LIM domains 1 isoform 3 [Homo sapiens]
          Length = 309

 Score =  119 bits (297), Expect = 6e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 34  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 93

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 179
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 94  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 147

Query: 180 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 238
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 148 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 207

Query: 239 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 293
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 208 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 267

Query: 294 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 268 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 308



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 32  DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 91
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 62  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 121

Query: 92  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 149
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 122 TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 181

Query: 150 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 208
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 182 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 236

Query: 209 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 263
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 237 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 296

Query: 264 KGLAYC 269
           +   YC
Sbjct: 297 QEQVYC 302



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 130 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 189

Query: 99  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 158
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 190 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 249

Query: 159 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 212
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 250 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 304

Query: 213 CHDKM 217
           C  K+
Sbjct: 305 CAKKL 309


>gi|228480205 four and a half LIM domains 1 isoform 5 [Homo sapiens]
          Length = 296

 Score =  119 bits (297), Expect = 6e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 21  FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 80

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 179
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 81  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 134

Query: 180 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 238
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 135 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 194

Query: 239 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 293
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 195 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 254

Query: 294 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 255 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 295



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 32  DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 91
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 49  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 108

Query: 92  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 149
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 109 TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 168

Query: 150 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 208
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 169 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 223

Query: 209 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 263
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 224 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 283

Query: 264 KGLAYC 269
           +   YC
Sbjct: 284 QEQVYC 289



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 117 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 176

Query: 99  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 158
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 177 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 236

Query: 159 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 212
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 237 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 291

Query: 213 CHDKM 217
           C  K+
Sbjct: 292 CAKKL 296


>gi|21361122 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  119 bits (297), Expect = 6e-27
 Identities = 80/282 (28%), Positives = 113/282 (40%), Gaps = 18/282 (6%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C  P     + + +G   C   F    A  C  C + I    + +   N  WH  
Sbjct: 5   FDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWHDT 64

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNRE---KAKGLGKYICQRCHLVIDEQPLMFR 179
           CFRC  C   LA+  FV    + LC  C  RE   K KG  K I      V  +Q + ++
Sbjct: 65  CFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAI------VAGDQNVEYK 118

Query: 180 SDAYHPDHFNCTHCGKELTAEARELKGE-LYCLPCHDKMGVPICGACRRPIEGRVVNALG 238
              +H D F C++C + +   +   KGE  YC+ CH+      C  C + I    +    
Sbjct: 119 GTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAKHCVKCNKAITSGGITYQD 178

Query: 239 KQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG-----DVV 293
           + WH + FVC  C K   G R    +   YC   Y       C  C + I G      VV
Sbjct: 179 QPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKKCAGCKNPITGFGKGSSVV 238

Query: 294 SALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
           +   ++W   CF C  C+  L  K +FV    +  C  C +K
Sbjct: 239 AYEGQSWHDYCFHCKKCSVNLANK-RFVFHQEQVYCPDCAKK 279



 Score =  100 bits (249), Expect = 2e-21
 Identities = 59/246 (23%), Positives = 91/246 (36%), Gaps = 13/246 (5%)

Query: 32  DALANAVCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHD 91
           D      C  C+       + V+     +H+ CF CA+C  P     F   + +  C   
Sbjct: 33  DKFCANTCVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKC 92

Query: 92  FQMLFAPCCGSCGEFIIG--RVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRP 149
                +P C  C + I+   + ++     WH  CF C  C   +    F        C  
Sbjct: 93  TTREDSPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVT 152

Query: 150 CHNREKAKGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEA-RELKGEL 208
           CH  + AK      C +C+  I    + ++   +H D F C  C K+L  +    ++ + 
Sbjct: 153 CHETKFAKH-----CVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQY 207

Query: 209 YCLPCHDKMGVPICGACRRPIEG-----RVVNALGKQWHVEHFVCAKCEKPFLGHRHYEK 263
           YC+ C+       C  C+ PI G      VV   G+ WH   F C KC       R    
Sbjct: 208 YCVDCYKNFVAKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFH 267

Query: 264 KGLAYC 269
           +   YC
Sbjct: 268 QEQVYC 273



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 45/185 (24%), Positives = 69/185 (37%), Gaps = 11/185 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C       ++ V   G ++H+ CF C+ C +    G F+      YC    +  FA 
Sbjct: 101 CKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFAK 160

Query: 99  CCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKG 158
            C  C + I    I   +  WH  CF C  C  +LA   F     ++ C  C+    AK 
Sbjct: 161 HCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFVAKK 220

Query: 159 LGKYICQRCHLVI-----DEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGE-LYCLP 212
                C  C   I         + +   ++H   F+C  C   L  +      E +YC  
Sbjct: 221 -----CAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYCPD 275

Query: 213 CHDKM 217
           C  K+
Sbjct: 276 CAKKL 280


>gi|87159836 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  117 bits (293), Expect = 2e-26
 Identities = 72/269 (26%), Positives = 111/269 (41%), Gaps = 14/269 (5%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C        +   E   YC   F+ LFA  C  CG+ I    + +   + +WH  
Sbjct: 5   FDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEA 64

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVI--DEQPLMFRS 180
           CF C  C   L D  F     + LC  C++ E +       CQ C   I    + + ++ 
Sbjct: 65  CFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSK-----CQECKKTIMPGTRKMEYKG 119

Query: 181 DAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDKMGVPICGACRRPIEGRVVNALGK 239
            ++H   F C  C + +  ++   K  + +C+PC++K     C  C++PI    V    +
Sbjct: 120 SSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ 179

Query: 240 QWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG----DVVSA 295
            WH E FVC  C K   G R   +   AYC   +  L+   C  C++ I G      +S 
Sbjct: 180 PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISF 239

Query: 296 LNKAWCVSCFSCSTCNSKLTLKNKFVEFD 324
             + W   CF+C  C+  L  +    E D
Sbjct: 240 EERQWHNDCFNCKKCSLSLVGRGFLTERD 268



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 55/226 (24%), Positives = 96/226 (42%), Gaps = 12/226 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C        + ++     +HE CF C+QC     +  F   E +  C   +   ++ 
Sbjct: 40  CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99

Query: 99  CCGSCGEFII--GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKA 156
            C  C + I+   R ++   ++WH  CF C  C   +    F+    ++ C PC+ ++ A
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159

Query: 157 KGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL-YCLPCHD 215
                  C +C   I    + +R   +H + F CT C K+L+ +    + +  YCL C  
Sbjct: 160 MQ-----CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFC 214

Query: 216 KMGVPICGACRRPIEG----RVVNALGKQWHVEHFVCAKCEKPFLG 257
            +    C  C  PI G    + ++   +QWH + F C KC    +G
Sbjct: 215 DLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVG 260



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 38/155 (24%), Positives = 65/155 (41%), Gaps = 6/155 (3%)

Query: 186 DHFNCTHCGKELTAEARELKGEL-YCLPCHDKMGVPICGACRRPI--EGRVVNALGKQWH 242
           + F+C HC + L  +   L+ E  YC+ C + +    C  C +PI  + + ++   + WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 243 VEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV--VSALNKAW 300
              F C++C    +      K+    C   Y+  +   C  C   I      +     +W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 301 CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
             +CF C  C   +  K+ F+  D +  C  CYEK
Sbjct: 123 HETCFICHRCQQPIGTKS-FIPKDNQNFCVPCYEK 156



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 29/95 (30%), Positives = 39/95 (41%), Gaps = 4/95 (4%)

Query: 60  YHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIG----RVIKAM 115
           +H+ CFVC  C +      F   +   YC + F  L+A  C  C   I G    + I   
Sbjct: 181 WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFE 240

Query: 116 NNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPC 150
              WH  CF C+ C + L   GF+      LC  C
Sbjct: 241 ERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDC 275



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 3/119 (2%)

Query: 244 EHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV--VSALNKAWC 301
           E F C  C +   G ++  ++   YC   +  LF + C  C   I  D   +S  ++ W 
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 302 VSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKAT 360
            +CF CS C + L  K  F   + + +C  CY        +  KK     +RK + K +
Sbjct: 63  EACFHCSQCRNSLVDK-PFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS 120


>gi|87159834 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  117 bits (293), Expect = 2e-26
 Identities = 72/269 (26%), Positives = 111/269 (41%), Gaps = 14/269 (5%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C        +   E   YC   F+ LFA  C  CG+ I    + +   + +WH  
Sbjct: 5   FDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEA 64

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVI--DEQPLMFRS 180
           CF C  C   L D  F     + LC  C++ E +       CQ C   I    + + ++ 
Sbjct: 65  CFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSK-----CQECKKTIMPGTRKMEYKG 119

Query: 181 DAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDKMGVPICGACRRPIEGRVVNALGK 239
            ++H   F C  C + +  ++   K  + +C+PC++K     C  C++PI    V    +
Sbjct: 120 SSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ 179

Query: 240 QWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG----DVVSA 295
            WH E FVC  C K   G R   +   AYC   +  L+   C  C++ I G      +S 
Sbjct: 180 PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISF 239

Query: 296 LNKAWCVSCFSCSTCNSKLTLKNKFVEFD 324
             + W   CF+C  C+  L  +    E D
Sbjct: 240 EERQWHNDCFNCKKCSLSLVGRGFLTERD 268



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 55/226 (24%), Positives = 96/226 (42%), Gaps = 12/226 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C        + ++     +HE CF C+QC     +  F   E +  C   +   ++ 
Sbjct: 40  CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99

Query: 99  CCGSCGEFII--GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKA 156
            C  C + I+   R ++   ++WH  CF C  C   +    F+    ++ C PC+ ++ A
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159

Query: 157 KGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL-YCLPCHD 215
                  C +C   I    + +R   +H + F CT C K+L+ +    + +  YCL C  
Sbjct: 160 MQ-----CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFC 214

Query: 216 KMGVPICGACRRPIEG----RVVNALGKQWHVEHFVCAKCEKPFLG 257
            +    C  C  PI G    + ++   +QWH + F C KC    +G
Sbjct: 215 DLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVG 260



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 38/155 (24%), Positives = 65/155 (41%), Gaps = 6/155 (3%)

Query: 186 DHFNCTHCGKELTAEARELKGEL-YCLPCHDKMGVPICGACRRPI--EGRVVNALGKQWH 242
           + F+C HC + L  +   L+ E  YC+ C + +    C  C +PI  + + ++   + WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 243 VEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV--VSALNKAW 300
              F C++C    +      K+    C   Y+  +   C  C   I      +     +W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 301 CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
             +CF C  C   +  K+ F+  D +  C  CYEK
Sbjct: 123 HETCFICHRCQQPIGTKS-FIPKDNQNFCVPCYEK 156



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 29/95 (30%), Positives = 39/95 (41%), Gaps = 4/95 (4%)

Query: 60  YHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIG----RVIKAM 115
           +H+ CFVC  C +      F   +   YC + F  L+A  C  C   I G    + I   
Sbjct: 181 WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFE 240

Query: 116 NNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPC 150
              WH  CF C+ C + L   GF+      LC  C
Sbjct: 241 ERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDC 275



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 3/119 (2%)

Query: 244 EHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV--VSALNKAWC 301
           E F C  C +   G ++  ++   YC   +  LF + C  C   I  D   +S  ++ W 
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 302 VSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKAT 360
            +CF CS C + L  K  F   + + +C  CY        +  KK     +RK + K +
Sbjct: 63  EACFHCSQCRNSLVDK-PFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS 120


>gi|42403575 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  117 bits (293), Expect = 2e-26
 Identities = 72/269 (26%), Positives = 111/269 (41%), Gaps = 14/269 (5%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C        +   E   YC   F+ LFA  C  CG+ I    + +   + +WH  
Sbjct: 5   FDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEA 64

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVI--DEQPLMFRS 180
           CF C  C   L D  F     + LC  C++ E +       CQ C   I    + + ++ 
Sbjct: 65  CFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSK-----CQECKKTIMPGTRKMEYKG 119

Query: 181 DAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDKMGVPICGACRRPIEGRVVNALGK 239
            ++H   F C  C + +  ++   K  + +C+PC++K     C  C++PI    V    +
Sbjct: 120 SSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ 179

Query: 240 QWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG----DVVSA 295
            WH E FVC  C K   G R   +   AYC   +  L+   C  C++ I G      +S 
Sbjct: 180 PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISF 239

Query: 296 LNKAWCVSCFSCSTCNSKLTLKNKFVEFD 324
             + W   CF+C  C+  L  +    E D
Sbjct: 240 EERQWHNDCFNCKKCSLSLVGRGFLTERD 268



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 55/226 (24%), Positives = 96/226 (42%), Gaps = 12/226 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C        + ++     +HE CF C+QC     +  F   E +  C   +   ++ 
Sbjct: 40  CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99

Query: 99  CCGSCGEFII--GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKA 156
            C  C + I+   R ++   ++WH  CF C  C   +    F+    ++ C PC+ ++ A
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159

Query: 157 KGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL-YCLPCHD 215
                  C +C   I    + +R   +H + F CT C K+L+ +    + +  YCL C  
Sbjct: 160 MQ-----CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFC 214

Query: 216 KMGVPICGACRRPIEG----RVVNALGKQWHVEHFVCAKCEKPFLG 257
            +    C  C  PI G    + ++   +QWH + F C KC    +G
Sbjct: 215 DLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVG 260



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 38/155 (24%), Positives = 65/155 (41%), Gaps = 6/155 (3%)

Query: 186 DHFNCTHCGKELTAEARELKGEL-YCLPCHDKMGVPICGACRRPI--EGRVVNALGKQWH 242
           + F+C HC + L  +   L+ E  YC+ C + +    C  C +PI  + + ++   + WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 243 VEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV--VSALNKAW 300
              F C++C    +      K+    C   Y+  +   C  C   I      +     +W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 301 CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
             +CF C  C   +  K+ F+  D +  C  CYEK
Sbjct: 123 HETCFICHRCQQPIGTKS-FIPKDNQNFCVPCYEK 156



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 29/95 (30%), Positives = 39/95 (41%), Gaps = 4/95 (4%)

Query: 60  YHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIG----RVIKAM 115
           +H+ CFVC  C +      F   +   YC + F  L+A  C  C   I G    + I   
Sbjct: 181 WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFE 240

Query: 116 NNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPC 150
              WH  CF C+ C + L   GF+      LC  C
Sbjct: 241 ERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDC 275



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 3/119 (2%)

Query: 244 EHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV--VSALNKAWC 301
           E F C  C +   G ++  ++   YC   +  LF + C  C   I  D   +S  ++ W 
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 302 VSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKAT 360
            +CF CS C + L  K  F   + + +C  CY        +  KK     +RK + K +
Sbjct: 63  EACFHCSQCRNSLVDK-PFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS 120


>gi|87159832 four and a half LIM domains 2 [Homo sapiens]
          Length = 279

 Score =  117 bits (293), Expect = 2e-26
 Identities = 72/269 (26%), Positives = 111/269 (41%), Gaps = 14/269 (5%)

Query: 65  FVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFI--IGRVIKAMNNNWHPG 122
           F C  C        +   E   YC   F+ LFA  C  CG+ I    + +   + +WH  
Sbjct: 5   FDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWHEA 64

Query: 123 CFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGKYICQRCHLVI--DEQPLMFRS 180
           CF C  C   L D  F     + LC  C++ E +       CQ C   I    + + ++ 
Sbjct: 65  CFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSK-----CQECKKTIMPGTRKMEYKG 119

Query: 181 DAYHPDHFNCTHCGKELTAEARELK-GELYCLPCHDKMGVPICGACRRPIEGRVVNALGK 239
            ++H   F C  C + +  ++   K  + +C+PC++K     C  C++PI    V    +
Sbjct: 120 SSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHAMQCVQCKKPITTGGVTYREQ 179

Query: 240 QWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEG----DVVSA 295
            WH E FVC  C K   G R   +   AYC   +  L+   C  C++ I G      +S 
Sbjct: 180 PWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISF 239

Query: 296 LNKAWCVSCFSCSTCNSKLTLKNKFVEFD 324
             + W   CF+C  C+  L  +    E D
Sbjct: 240 EERQWHNDCFNCKKCSLSLVGRGFLTERD 268



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 55/226 (24%), Positives = 96/226 (42%), Gaps = 12/226 (5%)

Query: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAP 98
           C+ C        + ++     +HE CF C+QC     +  F   E +  C   +   ++ 
Sbjct: 40  CEECGKPIGCDCKDLSYKDRHWHEACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSS 99

Query: 99  CCGSCGEFII--GRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKA 156
            C  C + I+   R ++   ++WH  CF C  C   +    F+    ++ C PC+ ++ A
Sbjct: 100 KCQECKKTIMPGTRKMEYKGSSWHETCFICHRCQQPIGTKSFIPKDNQNFCVPCYEKQHA 159

Query: 157 KGLGKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEARELKGEL-YCLPCHD 215
                  C +C   I    + +R   +H + F CT C K+L+ +    + +  YCL C  
Sbjct: 160 MQ-----CVQCKKPITTGGVTYREQPWHKECFVCTACRKQLSGQRFTARDDFAYCLNCFC 214

Query: 216 KMGVPICGACRRPIEG----RVVNALGKQWHVEHFVCAKCEKPFLG 257
            +    C  C  PI G    + ++   +QWH + F C KC    +G
Sbjct: 215 DLYAKKCAGCTNPISGLGGTKYISFEERQWHNDCFNCKKCSLSLVG 260



 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 38/155 (24%), Positives = 65/155 (41%), Gaps = 6/155 (3%)

Query: 186 DHFNCTHCGKELTAEARELKGEL-YCLPCHDKMGVPICGACRRPI--EGRVVNALGKQWH 242
           + F+C HC + L  +   L+ E  YC+ C + +    C  C +PI  + + ++   + WH
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 243 VEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV--VSALNKAW 300
              F C++C    +      K+    C   Y+  +   C  C   I      +     +W
Sbjct: 63  EACFHCSQCRNSLVDKPFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGSSW 122

Query: 301 CVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335
             +CF C  C   +  K+ F+  D +  C  CYEK
Sbjct: 123 HETCFICHRCQQPIGTKS-FIPKDNQNFCVPCYEK 156



 Score = 55.8 bits (133), Expect = 6e-08
 Identities = 29/95 (30%), Positives = 39/95 (41%), Gaps = 4/95 (4%)

Query: 60  YHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIG----RVIKAM 115
           +H+ CFVC  C +      F   +   YC + F  L+A  C  C   I G    + I   
Sbjct: 181 WHKECFVCTACRKQLSGQRFTARDDFAYCLNCFCDLYAKKCAGCTNPISGLGGTKYISFE 240

Query: 116 NNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPC 150
              WH  CF C+ C + L   GF+      LC  C
Sbjct: 241 ERQWHNDCFNCKKCSLSLVGRGFLTERDDILCPDC 275



 Score = 48.9 bits (115), Expect = 7e-06
 Identities = 31/119 (26%), Positives = 50/119 (42%), Gaps = 3/119 (2%)

Query: 244 EHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVCYNCSHVIEGDV--VSALNKAWC 301
           E F C  C +   G ++  ++   YC   +  LF + C  C   I  D   +S  ++ W 
Sbjct: 3   ERFDCHHCNESLFGKKYILREESPYCVVCFETLFANTCEECGKPIGCDCKDLSYKDRHWH 62

Query: 302 VSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEKFPLELKKRLKKLSELTSRKAQPKAT 360
            +CF CS C + L  K  F   + + +C  CY        +  KK     +RK + K +
Sbjct: 63  EACFHCSQCRNSLVDK-PFAAKEDQLLCTDCYSNEYSSKCQECKKTIMPGTRKMEYKGS 120


>gi|51173715 actin-binding LIM protein 1 isoform c [Homo sapiens]
          Length = 746

 Score =  114 bits (285), Expect = 1e-25
 Identities = 72/227 (31%), Positives = 97/227 (42%), Gaps = 17/227 (7%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 159
           C  CGE   G V++    ++H  CF C++C  +LA  GF    G +LC   + R      
Sbjct: 39  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTR- 97

Query: 160 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHC------GKELTAEARELKGELYCLPC 213
               C  C   ++ + +      YHP+ F CT C      G  +T   R+   +L   P 
Sbjct: 98  ----CHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPM 153

Query: 214 HDKMGVPI----CGACRRPIE-GRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY 268
                       C  C R I+ G+ + AL KQWH+  F C  C K   G  +  K G  Y
Sbjct: 154 SSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPY 212

Query: 269 CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLT 315
           CE  Y  LFG  C  C   I G V+ A +K +  SC  CS CN   T
Sbjct: 213 CEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFT 259



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 58/201 (28%), Positives = 84/201 (41%), Gaps = 5/201 (2%)

Query: 60  YHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNW 119
           +H  CF C  C     +G F+   G   C  D+Q ++   C  CGEF+ G V+ A+   +
Sbjct: 58  FHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTY 117

Query: 120 HPGCFRCELCDVELADLGFVKNAGRH-LCRPCHNREKAKGLGKYICQRC----HLVIDEQ 174
           HP CF C +C         V   GR  LC+ C     +          C      + + Q
Sbjct: 118 HPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQ 177

Query: 175 PLMFRSDAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVV 234
            L+     +H   F C  CGK LT E     G  YC   +  +    C AC + I G+V+
Sbjct: 178 ALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLFGVKCEACHQFITGKVL 237

Query: 235 NALGKQWHVEHFVCAKCEKPF 255
            A  K +H     C++C + F
Sbjct: 238 EAGDKHYHPSCARCSRCNQMF 258



 Score = 78.6 bits (192), Expect = 8e-15
 Identities = 47/157 (29%), Positives = 68/157 (43%), Gaps = 16/157 (10%)

Query: 52  IVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGR----KYCEHDF-----QMLFAPCCGS 102
           +V + G+ YH +CF C  C RPFP G    F GR    + C         +  F+  C  
Sbjct: 109 VVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAG 168

Query: 103 CGEFI-IGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGK 161
           CG  I  G+ + A++  WH GCF+C+ C   L    ++   G   C      +  +GL  
Sbjct: 169 CGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTG-EYISKDGAPYC-----EKDYQGLFG 222

Query: 162 YICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELT 198
             C+ CH  I  + L      YHP    C+ C +  T
Sbjct: 223 VKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFT 259



 Score = 32.0 bits (71), Expect = 0.90
 Identities = 11/42 (26%), Positives = 20/42 (47%)

Query: 281 CYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVE 322
           C+ C    +G+V+    K + + CF+C  C   L     F++
Sbjct: 39  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIK 80


>gi|51173713 actin-binding LIM protein 1 isoform b [Homo sapiens]
          Length = 718

 Score =  114 bits (285), Expect = 1e-25
 Identities = 72/227 (31%), Positives = 97/227 (42%), Gaps = 17/227 (7%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 159
           C  CGE   G V++    ++H  CF C++C  +LA  GF    G +LC   + R      
Sbjct: 39  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTR- 97

Query: 160 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHC------GKELTAEARELKGELYCLPC 213
               C  C   ++ + +      YHP+ F CT C      G  +T   R+   +L   P 
Sbjct: 98  ----CHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPM 153

Query: 214 HDKMGVPI----CGACRRPIE-GRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY 268
                       C  C R I+ G+ + AL KQWH+  F C  C K   G  +  K G  Y
Sbjct: 154 SSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPY 212

Query: 269 CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLT 315
           CE  Y  LFG  C  C   I G V+ A +K +  SC  CS CN   T
Sbjct: 213 CEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFT 259



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 58/201 (28%), Positives = 84/201 (41%), Gaps = 5/201 (2%)

Query: 60  YHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNW 119
           +H  CF C  C     +G F+   G   C  D+Q ++   C  CGEF+ G V+ A+   +
Sbjct: 58  FHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTY 117

Query: 120 HPGCFRCELCDVELADLGFVKNAGRH-LCRPCHNREKAKGLGKYICQRC----HLVIDEQ 174
           HP CF C +C         V   GR  LC+ C     +          C      + + Q
Sbjct: 118 HPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQ 177

Query: 175 PLMFRSDAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVV 234
            L+     +H   F C  CGK LT E     G  YC   +  +    C AC + I G+V+
Sbjct: 178 ALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLFGVKCEACHQFITGKVL 237

Query: 235 NALGKQWHVEHFVCAKCEKPF 255
            A  K +H     C++C + F
Sbjct: 238 EAGDKHYHPSCARCSRCNQMF 258



 Score = 78.6 bits (192), Expect = 8e-15
 Identities = 47/157 (29%), Positives = 68/157 (43%), Gaps = 16/157 (10%)

Query: 52  IVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGR----KYCEHDF-----QMLFAPCCGS 102
           +V + G+ YH +CF C  C RPFP G    F GR    + C         +  F+  C  
Sbjct: 109 VVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAG 168

Query: 103 CGEFI-IGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGK 161
           CG  I  G+ + A++  WH GCF+C+ C   L    ++   G   C      +  +GL  
Sbjct: 169 CGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTG-EYISKDGAPYC-----EKDYQGLFG 222

Query: 162 YICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELT 198
             C+ CH  I  + L      YHP    C+ C +  T
Sbjct: 223 VKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFT 259



 Score = 32.0 bits (71), Expect = 0.90
 Identities = 11/42 (26%), Positives = 20/42 (47%)

Query: 281 CYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVE 322
           C+ C    +G+V+    K + + CF+C  C   L     F++
Sbjct: 39  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIK 80


>gi|51173711 actin-binding LIM protein 1 isoform a [Homo sapiens]
          Length = 778

 Score =  114 bits (285), Expect = 1e-25
 Identities = 72/227 (31%), Positives = 97/227 (42%), Gaps = 17/227 (7%)

Query: 100 CGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGL 159
           C  CGE   G V++    ++H  CF C++C  +LA  GF    G +LC   + R      
Sbjct: 99  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTR- 157

Query: 160 GKYICQRCHLVIDEQPLMFRSDAYHPDHFNCTHC------GKELTAEARELKGELYCLPC 213
               C  C   ++ + +      YHP+ F CT C      G  +T   R+   +L   P 
Sbjct: 158 ----CHGCGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPM 213

Query: 214 HDKMGVPI----CGACRRPIE-GRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAY 268
                       C  C R I+ G+ + AL KQWH+  F C  C K   G  +  K G  Y
Sbjct: 214 SSSPKETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGE-YISKDGAPY 272

Query: 269 CETHYNQLFGDVCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLT 315
           CE  Y  LFG  C  C   I G V+ A +K +  SC  CS CN   T
Sbjct: 273 CEKDYQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFT 319



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 58/201 (28%), Positives = 84/201 (41%), Gaps = 5/201 (2%)

Query: 60  YHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFAPCCGSCGEFIIGRVIKAMNNNW 119
           +H  CF C  C     +G F+   G   C  D+Q ++   C  CGEF+ G V+ A+   +
Sbjct: 118 FHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHGCGEFVEGEVVTALGKTY 177

Query: 120 HPGCFRCELCDVELADLGFVKNAGRH-LCRPCHNREKAKGLGKYICQRC----HLVIDEQ 174
           HP CF C +C         V   GR  LC+ C     +          C      + + Q
Sbjct: 178 HPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAGCGRDIKNGQ 237

Query: 175 PLMFRSDAYHPDHFNCTHCGKELTAEARELKGELYCLPCHDKMGVPICGACRRPIEGRVV 234
            L+     +H   F C  CGK LT E     G  YC   +  +    C AC + I G+V+
Sbjct: 238 ALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKDYQGLFGVKCEACHQFITGKVL 297

Query: 235 NALGKQWHVEHFVCAKCEKPF 255
            A  K +H     C++C + F
Sbjct: 298 EAGDKHYHPSCARCSRCNQMF 318



 Score = 78.6 bits (192), Expect = 8e-15
 Identities = 47/157 (29%), Positives = 68/157 (43%), Gaps = 16/157 (10%)

Query: 52  IVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGR----KYCEHDF-----QMLFAPCCGS 102
           +V + G+ YH +CF C  C RPFP G    F GR    + C         +  F+  C  
Sbjct: 169 VVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPKETTFSSNCAG 228

Query: 103 CGEFI-IGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAKGLGK 161
           CG  I  G+ + A++  WH GCF+C+ C   L    ++   G   C      +  +GL  
Sbjct: 229 CGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTG-EYISKDGAPYC-----EKDYQGLFG 282

Query: 162 YICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELT 198
             C+ CH  I  + L      YHP    C+ C +  T
Sbjct: 283 VKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFT 319



 Score = 32.0 bits (71), Expect = 0.90
 Identities = 11/42 (26%), Positives = 20/42 (47%)

Query: 281 CYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVE 322
           C+ C    +G+V+    K + + CF+C  C   L     F++
Sbjct: 99  CHKCGEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIK 140


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.326    0.139    0.475 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,057,309
Number of Sequences: 37866
Number of extensions: 800042
Number of successful extensions: 4947
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 130
Number of HSP's successfully gapped in prelim test: 212
Number of HSP's that attempted gapping in prelim test: 3216
Number of HSP's gapped (non-prelim): 1060
length of query: 365
length of database: 18,247,518
effective HSP length: 104
effective length of query: 261
effective length of database: 14,309,454
effective search space: 3734767494
effective search space used: 3734767494
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 62 (28.5 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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