Guide to the Human Genome
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Search of human proteins with 40789265

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40789265 beta
1,4-N-acetylgalactosaminyltransferase-transferase 4 [Homo sapiens]
         (1039 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40789265 beta 1,4-N-acetylgalactosaminyltransferase-transfera...  2137   0.0  
gi|71043500 beta 1,4-N-acetylgalactosaminyltransferase-transfera...   873   0.0  
gi|194473684 chondroitin sulfate N-acetylgalactosaminyltransfera...    85   3e-16
gi|194473683 chondroitin sulfate N-acetylgalactosaminyltransfera...    85   3e-16
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     78   5e-14
gi|24429592 chondroitin sulfate N-acetylgalactosaminyltransferas...    76   1e-13
gi|31542309 chondroitin sulfate synthase 1 [Homo sapiens]              73   1e-12
gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain ...    69   2e-11
gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Hom...    63   2e-09
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    63   2e-09
gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Hom...    63   2e-09
gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo sap...    63   2e-09
gi|19924099 synapsin I isoform Ia [Homo sapiens]                       62   3e-09
gi|19924097 synapsin I isoform Ib [Homo sapiens]                       62   3e-09
gi|74271903 chondroitin sulfate synthase 3 [Homo sapiens]              61   5e-09
gi|11386183 WAS protein family, member 2 [Homo sapiens]                61   6e-09
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...    60   1e-08
gi|4826998 splicing factor proline/glutamine rich (polypyrimidin...    59   2e-08
gi|163965366 nascent polypeptide-associated complex alpha subuni...    59   2e-08
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    59   2e-08
gi|85815829 SH3-domain binding protein 1 [Homo sapiens]                59   2e-08
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    59   3e-08
gi|23592228 extraembryonic, spermatogenesis, homeobox 1-like [Ho...    59   3e-08
gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]               58   5e-08
gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]                     57   7e-08
gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]                     57   7e-08
gi|117306167 proline-rich protein BstNI subfamily 3 precursor [H...    57   7e-08
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    57   9e-08
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    57   9e-08
gi|210032580 SET domain containing 1B [Homo sapiens]                   57   9e-08

>gi|40789265 beta 1,4-N-acetylgalactosaminyltransferase-transferase 4
            [Homo sapiens]
          Length = 1039

 Score = 2137 bits (5537), Expect = 0.0
 Identities = 1039/1039 (100%), Positives = 1039/1039 (100%)

Query: 1    MPRLPVKKIRKQMKLLLLLLLLSCAAWLTYVHLGLVRQGRALRQRLGYGRDGEKLTSETD 60
            MPRLPVKKIRKQMKLLLLLLLLSCAAWLTYVHLGLVRQGRALRQRLGYGRDGEKLTSETD
Sbjct: 1    MPRLPVKKIRKQMKLLLLLLLLSCAAWLTYVHLGLVRQGRALRQRLGYGRDGEKLTSETD 60

Query: 61   GRGVHAAPSTQRAEDSSESREEEQAPEGRDLDMLFPGGAGRLPLNFTHQTPPWREEYKGQ 120
            GRGVHAAPSTQRAEDSSESREEEQAPEGRDLDMLFPGGAGRLPLNFTHQTPPWREEYKGQ
Sbjct: 61   GRGVHAAPSTQRAEDSSESREEEQAPEGRDLDMLFPGGAGRLPLNFTHQTPPWREEYKGQ 120

Query: 121  VNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVKKLAVSPKWKNYGLRIFGFIHPARDGD 180
            VNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVKKLAVSPKWKNYGLRIFGFIHPARDGD
Sbjct: 121  VNLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVKKLAVSPKWKNYGLRIFGFIHPARDGD 180

Query: 181  VQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASR 240
            VQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASR
Sbjct: 181  VQFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASR 240

Query: 241  RYYFELLHKQDDRGSDHVEVGWRAFLPGLKFEVISSAHISLYTDESALKMDHVAHVPQSP 300
            RYYFELLHKQDDRGSDHVEVGWRAFLPGLKFEVISSAHISLYTDESALKMDHVAHVPQSP
Sbjct: 241  RYYFELLHKQDDRGSDHVEVGWRAFLPGLKFEVISSAHISLYTDESALKMDHVAHVPQSP 300

Query: 301  ASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPIARY 360
            ASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPIARY
Sbjct: 301  ASHVGGRPPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPIARY 360

Query: 361  QGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDE 420
            QGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDE
Sbjct: 361  QGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEEDE 420

Query: 421  VQRRAFLFLNPDDFLDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPP 480
            VQRRAFLFLNPDDFLDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPP
Sbjct: 421  VQRRAFLFLNPDDFLDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPP 480

Query: 481  RPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRA 540
            RPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRA
Sbjct: 481  RPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRA 540

Query: 541  PAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGR 600
            PAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGR
Sbjct: 541  PAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGR 600

Query: 601  EGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAA 660
            EGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAA
Sbjct: 601  EGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAA 660

Query: 661  SEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAEAVD 720
            SEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAEAVD
Sbjct: 661  SEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAEAVD 720

Query: 721  VTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLR 780
            VTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLR
Sbjct: 721  VTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLR 780

Query: 781  LPGARVGDADGESPEPAPAASVRPDGRPELCRPLRLAWRQDVMVHFIVPVKNQARWVAQF 840
            LPGARVGDADGESPEPAPAASVRPDGRPELCRPLRLAWRQDVMVHFIVPVKNQARWVAQF
Sbjct: 781  LPGARVGDADGESPEPAPAASVRPDGRPELCRPLRLAWRQDVMVHFIVPVKNQARWVAQF 840

Query: 841  LADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGLQAG 900
            LADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGLQAG
Sbjct: 841  LADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARLPRYQYLRRTGNFERSAGLQAG 900

Query: 901  VDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWE 960
            VDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWE
Sbjct: 901  VDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMRLSCGSSPRDPHGYWE 960

Query: 961  VNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYH 1020
            VNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYH
Sbjct: 961  VNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYH 1020

Query: 1021 SKRGMWSVRSRKGSRTGAS 1039
            SKRGMWSVRSRKGSRTGAS
Sbjct: 1021 SKRGMWSVRSRKGSRTGAS 1039


>gi|71043500 beta 1,4-N-acetylgalactosaminyltransferase-transferase 3
            [Homo sapiens]
          Length = 998

 Score =  873 bits (2256), Expect = 0.0
 Identities = 497/1053 (47%), Positives = 638/1053 (60%), Gaps = 96/1053 (9%)

Query: 5    PVKKIRKQMKLLLLLLLLSCAAWLTYVHLGLVRQ--GRALRQRLGYGRDGEKLTSETDGR 62
            PVK +R++ +LLL L ++S   W  Y+ L    Q  G  L +R G  R+   L      R
Sbjct: 15   PVKLLRRRFRLLLALAVVSVGLWTLYLELVASAQVGGNPLNRRYGSWRE---LAKALASR 71

Query: 63   GVHAA-PSTQRAEDSSESREEEQAPEGRDLDMLFPGGAGRLPLNFTHQTPPWREEYKGQV 121
             + A  P  Q       S E+       D+D      +  L  N   +  PW  E++G+ 
Sbjct: 72   NIPAVDPHLQFYHPQRLSLEDH------DIDQGVSSNSSYLKWN---KPVPWLSEFRGRA 122

Query: 122  NLHVFEDWCGGAVGHLRRNLHFPLFPHTRTTVKKLAVSPKWKNYGLRIFGFIHPARDGDV 181
            NLHVFEDWCG ++  LRRNLHFPL+PH RTT++KLAVSPKW NYGLRIFG++HP  DG +
Sbjct: 123  NLHVFEDWCGSSIQQLRRNLHFPLYPHIRTTLRKLAVSPKWTNYGLRIFGYLHPFTDGKI 182

Query: 182  QFSVASDDNSEFWLSLDESPAAAQLVAFVGKTGSEWTAPGEFTKFSSQVSKPRRLMASRR 241
            QF++A+DDN+EFWLSLD+  +  QL+A VGKTG EWTAPGEF KF SQ+SKP  L AS R
Sbjct: 183  QFAIAADDNAEFWLSLDDQVSGLQLLASVGKTGKEWTAPGEFGKFRSQISKPVSLSASHR 242

Query: 242  YYFELLHKQDDRGSDHVEVGWRAFLPGLKFEVISSAHISLYTDESALKMDHVAHVPQSPA 301
            YYFE+LHKQ++ G+DHVEV WR   PG KF +I S  +SL+T+E+ L+MD V H+PQ+ A
Sbjct: 243  YYFEVLHKQNEEGTDHVEVAWRRNDPGAKFTIIDSLSLSLFTNETFLQMDEVGHIPQTAA 302

Query: 302  SHVGGR---PPQEETSADMLRPDPRDTFFLTPRMESSSLENVLEPCAYAPTYVVKDFPIA 358
            SHV      P  E+  ADMLRPDPRDT +  P +  S L +VL  C Y P+Y+V   P+ 
Sbjct: 303  SHVDSSNALPRDEQPPADMLRPDPRDTLYRVPLIPKSHLRHVLPDCPYKPSYLVDGLPLQ 362

Query: 359  RYQGLQFVYLSFVYPNDYTRLTHMETDNKCFYRESPLYLERFGFYKYMKMDKEEGDEDEE 418
            RYQGL+FV+LSFVYPNDYTRL+HMET NKCFY+E+  Y +RF F +Y+K+D+ E    E+
Sbjct: 363  RYQGLRFVHLSFVYPNDYTRLSHMETHNKCFYQENAYYQDRFSFQEYIKIDQPEKQGLEQ 422

Query: 419  DEVQRRAFLFLNPDDFLDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGAT----- 473
               +         ++ L++   GE+ +    +     R       PA+  +  AT     
Sbjct: 423  PGFE---------ENLLEESQYGEVAEETPASNNQNARMLEGRQTPASTLEQDATDYRLR 473

Query: 474  LAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPG 533
                   +PR+G     S+  S A+        F GR       V+QP  +       P 
Sbjct: 474  SLRKLLAQPREGLLAPFSKRNSTAS--------FPGRTS--HIPVQQPEKRKQKPSPEPS 523

Query: 534  QRASPRAPAPRAPWPPFPGVFLHP-RPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPAR 592
            Q  SP +      WPP      HP + LP  Q+R P   PRP G     P+ TQ      
Sbjct: 524  QD-SPHSDK----WPPG-----HPVKNLP--QMRGPR--PRPAG---DSPRKTQWLNQVE 566

Query: 593  AQATQGGREGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGEEEEEGEDD 652
            +   +  R  + R   P AP        E   V +     QV G +   EGEEEEE ED 
Sbjct: 567  SYIAEQRRGDRMR---PQAP--GRGWHGEEEVVAAAGQEGQVEGEE---EGEEEEEEED- 617

Query: 653  GAPGDEAASEDSEEAAGPALGRWREDAIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQ 712
                    SE  E    P      +  ++W +TFS   +DF+ LR+DW DL CN SGNL 
Sbjct: 618  -------MSEVFEYV--PVF----DPVVNWDQTFSARNLDFQALRTDWIDLSCNTSGNLL 664

Query: 713  LPEAEAVDVTAQYMERLNARHGGRFALLRIVNVEKRRDSARGSRFLLELELQERGGGRLR 772
            LPE EA++VT  ++++LN R  GR+ L RIVNVEKR+D  RG R+LLELEL E+G   +R
Sbjct: 665  LPEQEALEVTRVFLKKLNQRSRGRYQLQRIVNVEKRQDQLRGGRYLLELELLEQGQRVVR 724

Query: 773  LSEYVFLRLPGARVGDADGESPEPAPAASV--RPDGR-----------PELCRPLRLAWR 819
            LSEYV  R     +  A GE  E      +   P  R           P+LC P   +W 
Sbjct: 725  LSEYVSAR-GWQGIDPAGGEEVEARNLQGLVWDPHNRRRQVLNTRAQEPKLCWPQGFSWS 783

Query: 820  QDVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARL 879
               +VHF+VPVKNQARWV QF+ DM  L   TGD  F++V+ D+ SEDMDVE AL+ ++L
Sbjct: 784  HRAVVHFVVPVKNQARWVQQFIKDMENLFQVTGDPHFNIVITDYSSEDMDVEMALKRSKL 843

Query: 880  PRYQYLRRTGNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAF 939
              YQY++ +GNFERSAGLQAG+D V+D  SI+FLCDLHIHFP  ++D IRKHCVEG++AF
Sbjct: 844  RSYQYVKLSGNFERSAGLQAGIDLVKDPHSIIFLCDLHIHFPAGVIDAIRKHCVEGKMAF 903

Query: 940  APVVMRLSCGSSPRDPHGYWEVNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWELLDR 999
            AP+VMRL CG++P+ P GYWEVNGFGL GIYKSD DR+GGMNT+EFRD+WGGEDWELLDR
Sbjct: 904  APMVMRLHCGATPQWPEGYWEVNGFGLLGIYKSDLDRIGGMNTKEFRDRWGGEDWELLDR 963

Query: 1000 VLQAGLEVERLRLRNFYHHYHSKRGMWSVRSRK 1032
            +LQAGL+VERL LRNF+HH+HSKRGMWS R  K
Sbjct: 964  ILQAGLDVERLSLRNFFHHFHSKRGMWSRRQMK 996


>gi|194473684 chondroitin sulfate N-acetylgalactosaminyltransferase 1
            [Homo sapiens]
          Length = 532

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 59/226 (26%), Positives = 102/226 (45%), Gaps = 24/226 (10%)

Query: 821  DVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMD-----VERALR 875
            + +++ IVP+  +     QF+ +   +     D R  + +V F  E+++     +E   +
Sbjct: 260  NTLINVIVPLAKRVDKFRQFMQNFREMCIEQ-DGRVHLTVVYFGKEEINEVKGILENTSK 318

Query: 876  AARLPRYQYLRRTGNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEG 935
            AA    + +++  G F R  GL  G    + ++ ++F CD+ I+F    L+  R +   G
Sbjct: 319  AANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPG 378

Query: 936  RLAFAPVVMR-----LSCGSSPRDP-----------HGYWEVNGFGLFGIYKSDFDRVGG 979
            +  F PV+       +  G     P            G+W   GFG+   Y+SDF  +GG
Sbjct: 379  KKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGG 438

Query: 980  MNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYHSKRGM 1025
             + +     WGGED  L  + L + L V R  +R  +H +H KR M
Sbjct: 439  FDLD--IKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKRCM 482


>gi|194473683 chondroitin sulfate N-acetylgalactosaminyltransferase 1
            [Homo sapiens]
          Length = 532

 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 59/226 (26%), Positives = 102/226 (45%), Gaps = 24/226 (10%)

Query: 821  DVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMD-----VERALR 875
            + +++ IVP+  +     QF+ +   +     D R  + +V F  E+++     +E   +
Sbjct: 260  NTLINVIVPLAKRVDKFRQFMQNFREMCIEQ-DGRVHLTVVYFGKEEINEVKGILENTSK 318

Query: 876  AARLPRYQYLRRTGNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEG 935
            AA    + +++  G F R  GL  G    + ++ ++F CD+ I+F    L+  R +   G
Sbjct: 319  AANFRNFTFIQLNGEFSRGKGLDVGARFWKGSNVLLFFCDVDIYFTSEFLNTCRLNTQPG 378

Query: 936  RLAFAPVVMR-----LSCGSSPRDP-----------HGYWEVNGFGLFGIYKSDFDRVGG 979
            +  F PV+       +  G     P            G+W   GFG+   Y+SDF  +GG
Sbjct: 379  KKVFYPVLFSQYNPGIIYGHHDAVPPLEQQLVIKKETGFWRDFGFGMTCQYRSDFINIGG 438

Query: 980  MNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYHSKRGM 1025
             + +     WGGED  L  + L + L V R  +R  +H +H KR M
Sbjct: 439  FDLD--IKGWGGEDVHLYRKYLHSNLIVVRTPVRGLFHLWHEKRCM 482


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 77.8 bits (190), Expect = 5e-14
 Identities = 111/388 (28%), Positives = 140/388 (36%), Gaps = 64/388 (16%)

Query: 450 TEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLG 509
           T  APPR+   +PA AA A P  T APP PP P     P  +RA   AA AA        
Sbjct: 107 TPPAPPRAPRGAPAAAAAAAPPPTPAPPPPPAPVAAAAP--ARAPRAAAAAA-------- 156

Query: 510 RAPPPRPAVEQPPPKVYVTRVRPGQRASPRA---PAPRAPWPPFPGVFLHPRPLPRVQLR 566
              PP P   QP P+         QRA+P A   PAP AP    P       P P V  R
Sbjct: 157 -TAPPSPGPAQPGPR--------AQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAR 207

Query: 567 APPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVT 626
            PP PP P  +    PQ  QP PP      +G   G  R  G A P          R V 
Sbjct: 208 EPPLPPPP--QPPAPPQQQQPPPPQPQPPPEG---GAVRAGGAARPV-------SLREVV 255

Query: 627 SFLSLSQVSGPQLPG---EGEEEEEGEDDG-----APGDEAASEDSEEAAGPALGRWRED 678
            +L  S  +G +L     +G  EEE    G       G  A          P     R  
Sbjct: 256 RYLGGSGGAGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRGDRPGRAPPAASARPS 315

Query: 679 AIDWQRTFSVGAVDFELLRSDWNDLRCNVSGNLQLPEAEAVDVTAQYMERLNARHGGRFA 738
                    V   + E    +  D   +VS   ++PE++     AQ+  +LN   G + A
Sbjct: 316 RSKRGGEERVLEKEEEEDDDEDEDEEDDVSEGSEVPESDR-PAGAQH-HQLNGERGPQSA 373

Query: 739 LLRI-----VNVEKRRDSARGSRFLLELELQERGGGRLRLSEYVFLRLPGARVGDADG-E 792
             R+         + +D  RG            G G  ++     +   G     A G +
Sbjct: 374 KERVKEWTPCGPHQGQDEGRG---------PAPGSGTRQVFSMAAMNKEGGTASVATGPD 424

Query: 793 SPEPAPAASVRP-----DGRPELCRPLR 815
           SP P P    +P     DG P  C P R
Sbjct: 425 SPSPVPLPPGKPALPGADGTPFGCPPGR 452



 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 69/248 (27%), Positives = 88/248 (35%), Gaps = 58/248 (23%)

Query: 449 PTEAAPPRSGP---QSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLP 505
           PT A PP   P    +PA A  A   A  APP+P   + G             RA R  P
Sbjct: 129 PTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPG------------PRAQRAAP 176

Query: 506 LFLGRAPPPRPAVEQPP---PKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPR 562
           L    APPP PA   PP   P     R  P   A+   P P  P PP P         P+
Sbjct: 177 L---AAPPPAPAA--PPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAP---------PQ 222

Query: 563 VQLRAPPRP-PRPHG---RRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNL 618
            Q   PP+P P P G   R  G  +    R   R     GG  G+  T G     ++   
Sbjct: 223 QQQPPPPQPQPPPEGGAVRAGGAARPVSLREVVRYLGGSGGAGGRL-TRGRVQGLLEEEA 281

Query: 619 SSEARPVTSFLSLSQVSGPQLPGEG---------------------EEEEEGEDDGAPGD 657
           ++  R   + L    +     PG                       +EEEE +D+    +
Sbjct: 282 AARGRLERTRLGALALPRGDRPGRAPPAASARPSRSKRGGEERVLEKEEEEDDDEDEDEE 341

Query: 658 EAASEDSE 665
           +  SE SE
Sbjct: 342 DDVSEGSE 349


>gi|24429592 chondroitin sulfate N-acetylgalactosaminyltransferase 2
            [Homo sapiens]
          Length = 542

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 57/224 (25%), Positives = 91/224 (40%), Gaps = 28/224 (12%)

Query: 823  MVHFIVPVKNQARWVAQFLADM--AALHARTGDSRFSVVLVDFESEDMD-----VERALR 875
            +++ IVP+  +     QF+ +     +H    D +  + +V F  E +      +E    
Sbjct: 271  IINIIVPLAERTEAFVQFMQNFRDVCIHQ---DKKIHLTVVYFGKEGLSKVKSILESVTS 327

Query: 876  AARLPRYQYLRRTGNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEG 935
             +    Y  +     F R  GL  G  A +    ++F CD+ I+F    L+  R +   G
Sbjct: 328  ESNFHNYTLVSLNEEFNRGRGLNVGARAWDKGEVLMFFCDVDIYFSAEFLNSCRLNAEPG 387

Query: 936  RLAFAPVVMRLSCGS----------------SPRDPHGYWEVNGFGLFGIYKSDFDRVGG 979
            +  F PVV  L   +                  +   G+W   GFG+   Y+SDF  +GG
Sbjct: 388  KKVFYPVVFSLYNPAIVYANQEVPPPVEQQLVHKKDSGFWRDFGFGMTCQYRSDFLTIGG 447

Query: 980  MNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYHSKR 1023
             + E     WGGED  L  + L   L V R  +   +H +H KR
Sbjct: 448  FDMEV--KGWGGEDVHLYRKYLHGDLIVIRTPVPGLFHLWHEKR 489


>gi|31542309 chondroitin sulfate synthase 1 [Homo sapiens]
          Length = 802

 Score = 73.2 bits (178), Expect = 1e-12
 Identities = 56/221 (25%), Positives = 96/221 (43%), Gaps = 23/221 (10%)

Query: 820  QDVMVHFIVPVKNQARWVAQFLADMAALHARTGDSRFSVVLVDFESEDMDVERALRAARL 879
            +D  ++ ++P+  +     +F+ +          +   VVL+     + D  + +   R 
Sbjct: 530  KDKKINILIPLSGRFDMFVRFMGNFEKTCLIPNQNVKLVVLLFNSDSNPDKAKQVELMRD 589

Query: 880  PRYQY-------LRRTGNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHC 932
             R +Y       L  +G F R+  L+ G     +  S++F CD+ + F    L   R + 
Sbjct: 590  YRIKYPKADMQILPVSGEFSRALALEVGSSQFNN-ESLLFFCDVDLVFTTEFLQRCRANT 648

Query: 933  VEGRLAFAPVVMR------LSCGSSPRDPH-------GYWEVNGFGLFGIYKSDFDRVGG 979
            V G+  + P++        +  G  P D H       G+W   GFG+  IYK D  RVGG
Sbjct: 649  VLGQQIYFPIIFSQYDPKIVYSGKVPSDNHFAFTQKTGFWRNYGFGITCIYKGDLVRVGG 708

Query: 980  MNTEEFRDQWGGEDWELLDRVLQAGLEVERLRLRNFYHHYH 1020
             +       WG ED +L ++V+QAGL+  R +     H +H
Sbjct: 709  FDVS--IQGWGLEDVDLFNKVVQAGLKTFRSQEVGVVHVHH 747


>gi|4502249 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
           isoform a [Homo sapiens]
          Length = 1006

 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 69/229 (30%), Positives = 92/229 (40%), Gaps = 32/229 (13%)

Query: 461 SPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQ 520
           SP PA PA P  T APP PPR         S    W   +         R+    PAV  
Sbjct: 770 SPPPAQPAAPSTTSAPPLPPRNVGKVQTASSANTLWKTNSVSVDGGSRQRSSSDPPAVHP 829

Query: 521 PPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHP-RPLPR--VQLRAPPRPPRPHGR 577
           P P + VT   P    +P  P P A  P        P +P P    Q+R PP PP+P  R
Sbjct: 830 PLPPLRVTSTNP---LTPTPPPPVAKTPSVMEALSQPSKPAPPGISQIRPPPLPPQPPSR 886

Query: 578 ------RTGGPQAT------QPRPPARAQATQG-GREGQARTLGPAAPTVDSNLSSEARP 624
                   G  ++T      QPR P    AT+  G    A  L P AP    + +++ +P
Sbjct: 887 LPQKKPAPGADKSTPLTNKGQPRGPVDLSATEALGPLSNAMVLQPPAPMPRKSQATKLKP 946

Query: 625 --VTSFLS--------LSQVSGPQLPGEGEEEEE---GEDDGAPGDEAA 660
             V +  +        L+   G  +  +GEE++E   G  DG PG + A
Sbjct: 947 KRVKALYNCVADNPDELTFSEGDVIIVDGEEDQEWWIGHIDGDPGRKGA 995


>gi|239754327 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 69/247 (27%), Positives = 91/247 (36%), Gaps = 39/247 (15%)

Query: 431 PDDFLDDEDEG---------ELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPR 481
           PDDF D E  G          L  S+   +  P + G     P  P  PG    PP    
Sbjct: 100 PDDFADKEVTGTSSLVNGNLRLYSSVG--DLRPGQYGQDLLIPPPP--PGPAPGPPQDIS 155

Query: 482 PRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAP 541
              GG+P  S      + A  P PL L   PPP P++  PPP V      P   +SP  P
Sbjct: 156 EPPGGSPLPSPP----STAPPPPPLLL--EPPPPPSMAPPPPPVLEALSPPHTLSSPSIP 209

Query: 542 APRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPA-----RAQAT 596
            P    PP P +     P P V   APP P  PH         T+  PP      ++   
Sbjct: 210 TPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPH------TVGTRLFPPGGVTKWKSDVA 263

Query: 597 QGGREGQARTLGP---AAPTVDSNLSSEARPVTSFLSLSQVSGP------QLPGEGEEEE 647
             GR+ +A    P    A    S L     P  +F    +V  P       +P +  +E 
Sbjct: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323

Query: 648 EGEDDGA 654
             +++GA
Sbjct: 324 PRKEEGA 330



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 48/207 (23%), Positives = 67/207 (32%), Gaps = 27/207 (13%)

Query: 436 DDEDEGELLDSLEPTEAAPPRSGP---QSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSR 492
           D   E +    L+ T  A PR G    Q+   A    P   L PP PP P          
Sbjct: 355 DRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPP----- 409

Query: 493 ALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPG 552
                  AA PLP     A PP    + P          P  +  P  P+P       P 
Sbjct: 410 ----LPPAAPPLPCAQKAAHPPAGFTKTPKSS------SPALKPKPNPPSPENTASSAPV 459

Query: 553 VFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAP 612
            +  P  + +  LR          RR     + +P P    Q+ +G +       GP  P
Sbjct: 460 DWRDPSQMEK--LRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKK-------GPRLP 510

Query: 613 TVDSNLSSEARPVTSFLSLSQVSGPQL 639
             ++ LS  A+     +    + G  L
Sbjct: 511 EKETLLSLPAKDTPPGVPEKSLGGSSL 537



 Score = 30.4 bits (67), Expect = 9.1
 Identities = 57/218 (26%), Positives = 73/218 (33%), Gaps = 33/218 (15%)

Query: 446 SLEPTEAAPPRSGPQS-PAPAAPAQPGATLAPPTPPRPRDG-GTPRHSRALSWAARAARP 503
           SL+P     P   P++ P PA P  P ATL P TPP+   G  TP     L   +    P
Sbjct: 630 SLQPKAMLGPAIPPKATPEPAIP--PKATLWPATPPKATLGPATP-----LKATSGPTTP 682

Query: 504 LPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRV 563
           L    G A               +     G    P  PA +    P              
Sbjct: 683 LKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP-------------S 729

Query: 564 QLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEAR 623
           Q R    P       T G +++   PP   + + GG  G+   L        S+LS E  
Sbjct: 730 QARGEGSPSEATRLPTQGARSSAAFPP---KTSPGG--GEVPCL-YKPHCHQSSLSREVA 783

Query: 624 PVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAAS 661
            V   L+    +GP     GE  E  E  G P    AS
Sbjct: 784 VVMPTLARGGAAGP-----GEPVEVKEPPGLPAKPPAS 816


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 74/256 (28%), Positives = 92/256 (35%), Gaps = 54/256 (21%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTPP---------RPRDGGTPRHSRALSWAAR 499
           P+ AAPP   P SP  + P  P AT  P  PP          P    +P  S + +   R
Sbjct: 697 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPR 756

Query: 500 AARPL---PLFLGRAPP---PRPAVEQPPPKVYVTRVRPGQRASPRAPAP---RAPWPPF 550
               L   PL +  +PP   P   + +PPP+       P  +A P  PA    +AP+ P 
Sbjct: 757 VPPLLAAPPLQVPPSPPASLPMSPLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPS 816

Query: 551 PGVFLHPRPLPRVQ---------LRAPPRPPRPHGRRTGGPQATQP-RPPARAQATQGGR 600
             + + P   P  Q         L+ PP PP         P    P RPP     T    
Sbjct: 817 ASLPMSPLATPPPQAPPVLAAPLLQVPPSPP-------ASPTLQAPRRPPTPGPDTSVSG 869

Query: 601 EGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGE------EEEEGEDDGA 654
                 L P  P   S   S           S +SGP L G         EE  G D G 
Sbjct: 870 PRLTLALAPGPPPPPSRSPS-----------STLSGPDLAGHSSSATSTPEELRGYDSGP 918

Query: 655 PGDEAAS--EDSEEAA 668
            G  AAS   D+E AA
Sbjct: 919 EGGAAASPPPDAELAA 934



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 62/220 (28%), Positives = 82/220 (37%), Gaps = 42/220 (19%)

Query: 444 LDSLEPTEAAPPRS------GPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWA 497
           L +L P +  PPR       GP S +P A   P  T A P PP P +  TP  +  L  +
Sbjct: 277 LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPP-PDNAATPLPA-TLPPS 334

Query: 498 ARAARPLPLF--LGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPP----FP 551
              A PLPL      APP    +  PP         P  +A P    P    PP     P
Sbjct: 335 PPLATPLPLAPPSPSAPPSLQTLPSPP-------ATPPSQAPPSMTTPPMQAPPSLQTIP 387

Query: 552 GVFLHPRPLPRVQLRAPPRP-----------------PRPHGRRTGGPQATQ---PRPPA 591
            + + P  L    L+APP P                    H   T  P+ TQ     P  
Sbjct: 388 PIQV-PHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSR 446

Query: 592 RAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTSFLSL 631
            A         QA    PA+P + ++LS    P++S L++
Sbjct: 447 PASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTI 486



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 47/156 (30%), Positives = 60/156 (38%), Gaps = 14/156 (8%)

Query: 449 PTEAAPPRSG----PQSPAPAAPAQPGATLA-PPTPPRPRDGGTPRHSRALSWAARAARP 503
           P  A+PP  G    P SP    P Q    LA PP    P    +P  S   + + +A   
Sbjct: 596 PALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAPNA 655

Query: 504 LPLFLGRAP---PPRPAVEQP-----PPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFL 555
           L + L +AP   PP P V+ P      P V  +   P Q A P   AP    PP P    
Sbjct: 656 LAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ-APPSLAAPPLQVPPSPPASP 714

Query: 556 HPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPA 591
              P      +APP    P  +    P A+ P  P+
Sbjct: 715 PMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPS 750



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 56/191 (29%), Positives = 70/191 (36%), Gaps = 12/191 (6%)

Query: 442 ELLDSLEPTE---AAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAA 498
           E L SL P     A+ P + P    P  PA P    APP+P       TP         A
Sbjct: 536 ENLPSLAPPPLQTASAPLTTPHLETPPCPA-PCPLQAPPSPLTTPPPETPSSIATPPPQA 594

Query: 499 RAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPA--PRAPW-PPFPGVFL 555
             A   P   G   PP   +  PPP+       P  +A P  PA  P +P   P P    
Sbjct: 595 PPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQA-- 652

Query: 556 HPRPLPRVQLRAP-PRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLG-PAAPT 613
            P  L    L+AP   PP P  +    P A+ P  P+    +Q      A  L  P +P 
Sbjct: 653 -PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPP 711

Query: 614 VDSNLSSEARP 624
               +S  A P
Sbjct: 712 ASPPMSPSATP 722



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 53/194 (27%), Positives = 68/194 (35%), Gaps = 39/194 (20%)

Query: 455 PRSGP--------QSPAPAAPAQPGATLAPP---TPPRP-----RDGGTPRHSRALSWAA 498
           PR+GP        ++PA   PA      APP   T P P     R  GT R         
Sbjct: 75  PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 134

Query: 499 RAARPLPLFLGRAP--PPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFP----- 551
           R +    +  G+A   P R A+              G R     P P  P P        
Sbjct: 135 RISAEETVARGKATEAPKRSALSA------------GARRDTSGPTPGTPSPAMARRSRA 182

Query: 552 -GVFLH-PRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGP 609
            G  +  PRP P  + R P   PR           T+P P AR + + GG  G  R    
Sbjct: 183 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG--GLQRPASR 240

Query: 610 AAPTVDSNLSSEAR 623
           +  +  + LSS AR
Sbjct: 241 SLSSSATPLSSPAR 254



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 48/194 (24%), Positives = 64/194 (32%), Gaps = 20/194 (10%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPR----HSRALSWAARAARPL 504
           P  A  P   P SP    P +  +++A P P  P    +P      S  LS  A      
Sbjct: 562 PCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQA 621

Query: 505 PLFLGRAP---PPRPAVEQP----------PPKVYVTRVRPGQRASPRAPAPRAPWPPFP 551
           P  L   P   PP P    P           P      +     + P +P  +AP+ P  
Sbjct: 622 PPXLALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPA 681

Query: 552 GVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLG-PA 610
              + P   P  Q  APP    P  +    P A+ P  P+     Q      A  L  P 
Sbjct: 682 SPPVSPSATPPSQ--APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPP 739

Query: 611 APTVDSNLSSEARP 624
           +P     +S  A P
Sbjct: 740 SPPASPPMSPSATP 753



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 77/302 (25%), Positives = 98/302 (32%), Gaps = 81/302 (26%)

Query: 444  LDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTP-----PRPRDGGTPRHSRALSWAA 498
            L +L    A+ P   P SP+ + P  P AT  P  P     P  +   +P  S  L    
Sbjct: 797  LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 856

Query: 499  RAARPLP--------LFLGRAPPPRPAVEQPPPKVYVTRVRPGQRAS------------- 537
            R   P P        L L  AP P P   + P          G  +S             
Sbjct: 857  RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 916

Query: 538  -PRAPAPRAPWPPFPGVFLHPR-----PLPRVQLRAPPRPPRPHGRRTG----------- 580
             P   A  +P P       HP      P P +  R  P  P P    TG           
Sbjct: 917  GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY 976

Query: 581  ---GPQATQPRP----PARAQATQGGREG-------------QAR----TLGPAAPTVDS 616
               GP++  P P    P  +  T GG+               QAR     LG    +V  
Sbjct: 977  ETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQ 1036

Query: 617  NLSSEARPVTSFLSLSQ-VSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRW 675
            +L S     T  L+ ++  +G    G G  E  G   GA    AA  D+E      LGRW
Sbjct: 1037 HLLSR----TLLLAAAEGAAGGSGGGPGGAEGGGVTGGA---RAALSDAE------LGRW 1083

Query: 676  RE 677
             E
Sbjct: 1084 AE 1085



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 60/234 (25%), Positives = 85/234 (36%), Gaps = 31/234 (13%)

Query: 456 RSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLF-----LGR 510
           ++G  +  PAA A    T  PP  PRP    TP   R L  AA A    PL      +G 
Sbjct: 9   KAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLG-AAGAVGRKPLAERAGGIGG 67

Query: 511 APPPRPAVEQPPPKVYVTRVR-PGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPP 569
           A  P  A    P +   T  R P  R        RAP    P     P P+      +  
Sbjct: 68  ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAP----PAKNTSPGPVSSPGRASGT 123

Query: 570 RPPRPHGRRTGGPQATQPRPPARAQATQGGRE------GQARTLGPAAPTVDSNLSSEAR 623
             P P G++  G + +     AR +AT+  +        +  T GP   T    ++  +R
Sbjct: 124 TRPGPLGQK--GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181

Query: 624 PVTSFLSL---SQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGR 674
              + + L   +  + P+ P EG  +            +ASE S     PA  R
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEGPRKSV---------SSASEHSTTEPSPAARR 226



 Score = 37.4 bits (85), Expect = 0.074
 Identities = 47/150 (31%), Positives = 54/150 (36%), Gaps = 47/150 (31%)

Query: 452 AAPPRSGPQSP----APAAPAQPGA----TLAPP--TPPRPRDGGTPRHSRALSWAARAA 501
           ++P RSGP +     APA P+QP       L PP  TPPR               AA A 
Sbjct: 250 SSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKD-------------AAPAL 296

Query: 502 RPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLP 561
            PL       P P     +P P        P   A+   PA   P PP         PLP
Sbjct: 297 GPLSSSPLATPSPSGTKARPVP--------PPDNAATPLPATLPPSPPLA------TPLP 342

Query: 562 RVQLRAPPRPPRPHGRRTGGPQATQPRPPA 591
                APP P  P   +T       P PPA
Sbjct: 343 L----APPSPSAPPSLQT------LPSPPA 362



 Score = 35.0 bits (79), Expect = 0.37
 Identities = 42/151 (27%), Positives = 49/151 (32%), Gaps = 28/151 (18%)

Query: 454 PPRSGPQS------------PAPAAPAQP--GATLAPPTPPRPRDGGTPRHSRALSWAAR 499
           PP  GP+             P+PAA  +P  G  L  P         TP  S A S  + 
Sbjct: 200 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS- 258

Query: 500 AARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRP 559
                     R  P  PA    P    +  +RP Q   PR  A  A  P        P P
Sbjct: 259 ---------ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSP 309

Query: 560 LPRVQLRAPPRPPRPHGRRTGGPQATQPRPP 590
                 +A P PP P    T  P    P PP
Sbjct: 310 ---SGTKARPVPP-PDNAATPLPATLPPSPP 336


>gi|239748855 PREDICTED: chromosome 6 open reading frame 132 [Homo
           sapiens]
          Length = 1188

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 69/247 (27%), Positives = 91/247 (36%), Gaps = 39/247 (15%)

Query: 431 PDDFLDDEDEG---------ELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPR 481
           PDDF D E  G          L  S+   +  P + G     P  P  PG    PP    
Sbjct: 100 PDDFADKEVTGTSSLVNGNLRLYSSVG--DLRPGQYGQDLLIPPPP--PGPAPGPPQDIS 155

Query: 482 PRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAP 541
              GG+P  S      + A  P PL L   PPP P++  PPP V      P   +SP  P
Sbjct: 156 EPPGGSPLPSPP----STAPPPPPLLL--EPPPPPSMAPPPPPVLEALSPPHTLSSPSIP 209

Query: 542 APRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPA-----RAQAT 596
            P    PP P +     P P V   APP P  PH         T+  PP      ++   
Sbjct: 210 TPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPH------TVGTRLFPPGGVTKWKSDVA 263

Query: 597 QGGREGQARTLGP---AAPTVDSNLSSEARPVTSFLSLSQVSGP------QLPGEGEEEE 647
             GR+ +A    P    A    S L     P  +F    +V  P       +P +  +E 
Sbjct: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323

Query: 648 EGEDDGA 654
             +++GA
Sbjct: 324 PRKEEGA 330



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 48/207 (23%), Positives = 67/207 (32%), Gaps = 27/207 (13%)

Query: 436 DDEDEGELLDSLEPTEAAPPRSGP---QSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSR 492
           D   E +    L+ T  A PR G    Q+   A    P   L PP PP P          
Sbjct: 355 DRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPP----- 409

Query: 493 ALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPG 552
                  AA PLP     A PP    + P          P  +  P  P+P       P 
Sbjct: 410 ----LPPAAPPLPCAQKAAHPPAGFTKTPKSS------SPALKPKPNPPSPENTASSAPV 459

Query: 553 VFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAP 612
            +  P  + +  LR          RR     + +P P    Q+ +G +       GP  P
Sbjct: 460 DWRDPSQMEK--LRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKK-------GPRLP 510

Query: 613 TVDSNLSSEARPVTSFLSLSQVSGPQL 639
             ++ LS  A+     +    + G  L
Sbjct: 511 EKETLLSLPAKDTPPGVPEKSLGGSSL 537



 Score = 30.4 bits (67), Expect = 9.1
 Identities = 57/218 (26%), Positives = 73/218 (33%), Gaps = 33/218 (15%)

Query: 446 SLEPTEAAPPRSGPQS-PAPAAPAQPGATLAPPTPPRPRDG-GTPRHSRALSWAARAARP 503
           SL+P     P   P++ P PA P  P ATL P TPP+   G  TP     L   +    P
Sbjct: 630 SLQPKAMLGPAIPPKATPEPAIP--PKATLWPATPPKATLGPATP-----LKATSGPTTP 682

Query: 504 LPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRV 563
           L    G A               +     G    P  PA +    P              
Sbjct: 683 LKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP-------------S 729

Query: 564 QLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEAR 623
           Q R    P       T G +++   PP   + + GG  G+   L        S+LS E  
Sbjct: 730 QARGEGSPSEATRLPTQGARSSAAFPP---KTSPGG--GEVPCL-YKPHCHQSSLSREVA 783

Query: 624 PVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAAS 661
            V   L+    +GP     GE  E  E  G P    AS
Sbjct: 784 VVMPTLARGGAAGP-----GEPVEVKEPPGLPAKPPAS 816


>gi|239742884 PREDICTED: hypothetical protein LOC647024 [Homo
           sapiens]
          Length = 1188

 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 69/247 (27%), Positives = 91/247 (36%), Gaps = 39/247 (15%)

Query: 431 PDDFLDDEDEG---------ELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPR 481
           PDDF D E  G          L  S+   +  P + G     P  P  PG    PP    
Sbjct: 100 PDDFADKEVTGTSSLVNGNLRLYSSVG--DLRPGQYGQDLLIPPPP--PGPAPGPPQDIS 155

Query: 482 PRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAP 541
              GG+P  S      + A  P PL L   PPP P++  PPP V      P   +SP  P
Sbjct: 156 EPPGGSPLPSPP----STAPPPPPLLL--EPPPPPSMAPPPPPVLEALSPPHTLSSPSIP 209

Query: 542 APRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPA-----RAQAT 596
            P    PP P +     P P V   APP P  PH         T+  PP      ++   
Sbjct: 210 TPPDFIPPAPPLAFLAPPPPPVPAPAPPAPASPH------TVGTRLFPPGGVTKWKSDVA 263

Query: 597 QGGREGQARTLGP---AAPTVDSNLSSEARPVTSFLSLSQVSGP------QLPGEGEEEE 647
             GR+ +A    P    A    S L     P  +F    +V  P       +P +  +E 
Sbjct: 264 LNGRQAEATRASPPRSPAEPKGSALGPNPEPHLTFPRSFKVPPPTPVRTSSIPVQEAQEA 323

Query: 648 EGEDDGA 654
             +++GA
Sbjct: 324 PRKEEGA 330



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 48/207 (23%), Positives = 67/207 (32%), Gaps = 27/207 (13%)

Query: 436 DDEDEGELLDSLEPTEAAPPRSGP---QSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSR 492
           D   E +    L+ T  A PR G    Q+   A    P   L PP PP P          
Sbjct: 355 DRAPEPDCPGELKATAPASPRLGQSQSQADERAGTPPPAPPLPPPAPPLPPPAPP----- 409

Query: 493 ALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPG 552
                  AA PLP     A PP    + P          P  +  P  P+P       P 
Sbjct: 410 ----LPPAAPPLPCAQKAAHPPAGFTKTPKSS------SPALKPKPNPPSPENTASSAPV 459

Query: 553 VFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAP 612
            +  P  + +  LR          RR     + +P P    Q+ +G +       GP  P
Sbjct: 460 DWRDPSQMEK--LRNELAAYLCGSRREDRFLSHRPGPTVAPQSKEGKK-------GPRLP 510

Query: 613 TVDSNLSSEARPVTSFLSLSQVSGPQL 639
             ++ LS  A+     +    + G  L
Sbjct: 511 EKETLLSLPAKDTPPGVPEKSLGGSSL 537



 Score = 30.4 bits (67), Expect = 9.1
 Identities = 57/218 (26%), Positives = 73/218 (33%), Gaps = 33/218 (15%)

Query: 446 SLEPTEAAPPRSGPQS-PAPAAPAQPGATLAPPTPPRPRDG-GTPRHSRALSWAARAARP 503
           SL+P     P   P++ P PA P  P ATL P TPP+   G  TP     L   +    P
Sbjct: 630 SLQPKAMLGPAIPPKATPEPAIP--PKATLWPATPPKATLGPATP-----LKATSGPTTP 682

Query: 504 LPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRV 563
           L    G A               +     G    P  PA +    P              
Sbjct: 683 LKATSGPAIASTATTLPTTTSQLMAEKDSGPAGQPEKPASQEVSTP-------------S 729

Query: 564 QLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEAR 623
           Q R    P       T G +++   PP   + + GG  G+   L        S+LS E  
Sbjct: 730 QARGEGSPSEATRLPTQGARSSAAFPP---KTSPGG--GEVPCL-YKPHCHQSSLSREVA 783

Query: 624 PVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAAS 661
            V   L+    +GP     GE  E  E  G P    AS
Sbjct: 784 VVMPTLARGGAAGP-----GEPVEVKEPPGLPAKPPAS 816


>gi|19924099 synapsin I isoform Ia [Homo sapiens]
          Length = 705

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 64/224 (28%), Positives = 85/224 (37%), Gaps = 43/224 (19%)

Query: 454 PPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPP 513
           PP+ GP  P P    Q      PP   RP   G  +H   L     A  PLP    R P 
Sbjct: 462 PPQGGPPQPGPGPQRQ-----GPPLQQRPPPQGQ-QHLSGLG--PPAGSPLPQ---RLPS 510

Query: 514 PRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPR 573
           P  A +QP  +        G+++ P A  P AP            P  R     PP  P 
Sbjct: 511 PTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAP------------PAAR-----PPASPS 553

Query: 574 PHGRRTGGPQATQ------PRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTS 627
           P  R+ G PQAT+      P PP  + A  GG++ Q     P  P   +  +S+A PV  
Sbjct: 554 PQ-RQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPR 612

Query: 628 FLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPA 671
                  +GP    +      G   G P  + A + S++   PA
Sbjct: 613 -------TGPPTTQQPRPSGPG-PAGRPKPQLAQKPSQDVPPPA 648



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 43/147 (29%), Positives = 55/147 (37%), Gaps = 17/147 (11%)

Query: 450 TEAAPPRSGP---QSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPL 506
           ++AAPP  G      P    P  P A   P +P   R  G P+ +R  S     + P P 
Sbjct: 520 SQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTS----VSGPAPP 575

Query: 507 FLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRA-------PWPPFPGVFLHPRP 559
               APP     + PP K       P ++AS   P PR        P P  PG     RP
Sbjct: 576 KASGAPPGGQQRQGPPQKP-PGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPA--GRP 632

Query: 560 LPRVQLRAPPRPPRPHGRRTGGPQATQ 586
            P++  +     P P     GGP   Q
Sbjct: 633 KPQLAQKPSQDVPPPATAAAGGPPHPQ 659



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 39/137 (28%), Positives = 53/137 (38%), Gaps = 26/137 (18%)

Query: 451 EAAPPRSGPQSPAPAAPAQPGATLAPP------TPPR--PRDGGTPRHSRALSWAARAA- 501
           +A PP++  Q+   + PA P A+ APP       PP+  P   G  R +       R   
Sbjct: 557 QAGPPQATRQTSV-SGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPRTGP 615

Query: 502 ----RPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHP 557
               +P P   G A  P+P + Q          +P Q   P A A  A  PP P +    
Sbjct: 616 PTTQQPRPSGPGPAGRPKPQLAQ----------KPSQDVPPPATA-AAGGPPHPQL-NKS 663

Query: 558 RPLPRVQLRAPPRPPRP 574
           + L        P PPRP
Sbjct: 664 QSLTNAFNLPEPAPPRP 680


>gi|19924097 synapsin I isoform Ib [Homo sapiens]
          Length = 669

 Score = 62.0 bits (149), Expect = 3e-09
 Identities = 64/224 (28%), Positives = 85/224 (37%), Gaps = 43/224 (19%)

Query: 454 PPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPP 513
           PP+ GP  P P    Q      PP   RP   G  +H   L     A  PLP    R P 
Sbjct: 462 PPQGGPPQPGPGPQRQ-----GPPLQQRPPPQGQ-QHLSGLG--PPAGSPLPQ---RLPS 510

Query: 514 PRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPR 573
           P  A +QP  +        G+++ P A  P AP            P  R     PP  P 
Sbjct: 511 PTSAPQQPASQAAPPTQGQGRQSRPVAGGPGAP------------PAAR-----PPASPS 553

Query: 574 PHGRRTGGPQATQ------PRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTS 627
           P  R+ G PQAT+      P PP  + A  GG++ Q     P  P   +  +S+A PV  
Sbjct: 554 PQ-RQAGPPQATRQTSVSGPAPPKASGAPPGGQQRQGPPQKPPGPAGPTRQASQAGPVPR 612

Query: 628 FLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPA 671
                  +GP    +      G   G P  + A + S++   PA
Sbjct: 613 -------TGPPTTQQPRPSGPG-PAGRPKPQLAQKPSQDVPPPA 648



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 47/156 (30%), Positives = 61/156 (39%), Gaps = 18/156 (11%)

Query: 450 TEAAPPRSGP---QSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPL 506
           ++AAPP  G      P    P  P A   P +P   R  G P+ +R  S     + P P 
Sbjct: 520 SQAAPPTQGQGRQSRPVAGGPGAPPAARPPASPSPQRQAGPPQATRQTS----VSGPAPP 575

Query: 507 FLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRA-------PWPPFPGVFLHPRP 559
               APP     + PP K       P ++AS   P PR        P P  PG     RP
Sbjct: 576 KASGAPPGGQQRQGPPQKP-PGPAGPTRQASQAGPVPRTGPPTTQQPRPSGPGPA--GRP 632

Query: 560 LPRVQLRAPPRPPRPHGRRTGGPQATQPR-PPARAQ 594
            P++  +     P P     GGP   Q +  PA+AQ
Sbjct: 633 KPQLAQKPSQDVPPPATAAAGGPPHPQLKASPAQAQ 668


>gi|74271903 chondroitin sulfate synthase 3 [Homo sapiens]
          Length = 882

 Score = 61.2 bits (147), Expect = 5e-09
 Identities = 40/145 (27%), Positives = 68/145 (46%), Gaps = 16/145 (11%)

Query: 889  GNFERSAGLQAGVDAVEDASSIVFLCDLHIHFPPNILDGIRKHCVEGRLAFAPVVMR--- 945
            G F R  GL+    A  D  +++  CD+ + F  + L   R + ++G+  + P++     
Sbjct: 693  GEFSRGLGLEMA-SAQFDNDTLLLFCDVDLIFREDFLQRCRDNTIQGQQVYYPIIFSQYD 751

Query: 946  ---LSCGSSPRDPH-------GYWEVNGFGLFGIYKSDFDRVGGMNTEEFRDQWGGEDWE 995
                + G+ P D +       G+W   G+G+  IYKSD    GG +T      WG ED +
Sbjct: 752  PKVTNGGNPPTDDYFIFSKKTGFWRDYGYGITCIYKSDLLGAGGFDTS--IQGWGLEDVD 809

Query: 996  LLDRVLQAGLEVERLRLRNFYHHYH 1020
            L ++V+ +GL   R +     H +H
Sbjct: 810  LYNKVILSGLRPFRSQEVGVVHIFH 834



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 32/104 (30%), Positives = 44/104 (42%), Gaps = 5/104 (4%)

Query: 575 HGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARP-VTSFLSLSQ 633
           +GR   GP+A   +P  + Q+    R  Q ++  PA   +      EA P +TSF S   
Sbjct: 48  YGRSAAGPRAGAQQPLPQPQS----RPRQEQSPPPARQDLQGPPLPEAAPGITSFRSSPW 103

Query: 634 VSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRWRE 677
              P L       E     G PG  AA  + EE  G A G+ R+
Sbjct: 104 QQPPPLQQRRRGREPEGATGLPGAPAAEGEPEEEDGGAAGQRRD 147



 Score = 32.0 bits (71), Expect = 3.1
 Identities = 41/150 (27%), Positives = 50/150 (33%), Gaps = 22/150 (14%)

Query: 441 GELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARA 500
           G  L S     AA PR+G Q P P   ++P    +PP P R    G P    A    +  
Sbjct: 41  GSSLCSYYGRSAAGPRAGAQQPLPQPQSRPRQEQSPP-PARQDLQGPPLPEAAPGITSFR 99

Query: 501 ARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPL 560
           + P               +QPPP     R R  + A+    AP A   P           
Sbjct: 100 SSPW--------------QQPPPLQQRRRGREPEGATGLPGAPAAEGEP------EEEDG 139

Query: 561 PRVQLRAPPRPPRPH-GRRTGGPQATQPRP 589
                R   RP   H G   GG  A   RP
Sbjct: 140 GAAGQRRDGRPGSSHNGSGDGGAAAPSARP 169


>gi|11386183 WAS protein family, member 2 [Homo sapiens]
          Length = 498

 Score = 60.8 bits (146), Expect = 6e-09
 Identities = 61/220 (27%), Positives = 78/220 (35%), Gaps = 45/220 (20%)

Query: 452 AAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRA 511
           A P RS   SP+   PA P  +     PP P+ G  P              P P      
Sbjct: 287 AGPKRSSVVSPSHPPPAPPLGS-----PPGPKPGFAPP-------------PAP-----P 323

Query: 512 PPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRP 571
           PPP P +  PPP   V    PG    P  P+    +PP P     P P P      P  P
Sbjct: 324 PPPPPMIGIPPPPPPVGFGSPGTPPPPSPPS----FPPHPDFAAPPPPPPPPAADYPTLP 379

Query: 572 PRPHGRRTGG--PQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTSFL 629
           P P  + TGG  P    P PP        G +GQ        P +   LS   +P +S  
Sbjct: 380 PPPLSQPTGGAPPPPPPPPPPGPPPPPFTGADGQ--------PAIPPPLSDTTKPKSSLP 431

Query: 630 SLSQVSGPQLPG--------EGEEEEEGEDDGAPGDEAAS 661
           ++S      L            EE+ E E     G++ A+
Sbjct: 432 AVSDARSDLLSAIRQGFQLRRVEEQREQEKRDVVGNDVAT 471



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 33/126 (26%), Positives = 38/126 (30%), Gaps = 32/126 (25%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFL 508
           P     P + P    P+ P  P     PP PP P          A  +      PL    
Sbjct: 338 PVGFGSPGTPPPPSPPSFPPHPDFAAPPPPPPPP----------AADYPTLPPPPLSQPT 387

Query: 509 GRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAP 568
           G APPP      PPP                 P P  P PPF G    P   P +     
Sbjct: 388 GGAPPP------PPP----------------PPPPGPPPPPFTGADGQPAIPPPLSDTTK 425

Query: 569 PRPPRP 574
           P+   P
Sbjct: 426 PKSSLP 431


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score = 60.1 bits (144), Expect = 1e-08
 Identities = 54/147 (36%), Positives = 57/147 (38%), Gaps = 28/147 (19%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFL 508
           P  A P   GP  P PA    P   L PP PP P   G P   + L        P PL  
Sbjct: 218 PGPAGP--GGPPPPFPAGQTPPRPPLGPPGPPGP--PGPPPPGQVL--------PPPL-- 263

Query: 509 GRAPPPRPAVEQPPPKVYVTRVRPGQ--RASPRAPAPRAPWPPFPGVFLHPRPLPRVQLR 566
             A PP      PPP ++     PGQ     P  P P  P PP PG    P P P  Q  
Sbjct: 264 --AGPPNRGDRPPPPVLF-----PGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGP 316

Query: 567 APPR---PPRPHGRRTGGPQATQPRPP 590
            PP    PPRP G    GP  T   PP
Sbjct: 317 PPPPGPFPPRPPGPL--GPPLTLAPPP 341



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 59/173 (34%), Positives = 61/173 (35%), Gaps = 27/173 (15%)

Query: 450 TEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPL----- 504
           T   PP   P  P P  P  PG  L PP    P  G  P              PL     
Sbjct: 235 TPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPP 294

Query: 505 ---PLFLGRAPPPRPAVEQ----PPPKVYVTRVRPGQRASP--RAPAPRAPWPPFPGVFL 555
              P   G  PPP P   Q    PPP  +  R  PG    P   AP P  P PP PG   
Sbjct: 295 GPPPPVPGYGPPPGPPPPQQGPPPPPGPFPPR-PPGPLGPPLTLAPPPHLPGPP-PGA-- 350

Query: 556 HPRPLPRVQLRAPPRPPRPHGRRTG---GPQATQP--RPPARAQATQG--GRE 601
            P P P V     P PP   G  T    GP  T P  RPP   +   G  GRE
Sbjct: 351 -PPPAPHVNPAFFP-PPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDYGPPGRE 401



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 27/78 (34%), Positives = 31/78 (39%), Gaps = 3/78 (3%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTP-PRPRDGGTP--RHSRALSWAARAARPLP 505
           P +  PP  GP  P P  P  P  TLAPP   P P  G  P   H     +       +P
Sbjct: 312 PQQGPPPPPGPFPPRPPGPLGPPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMP 371

Query: 506 LFLGRAPPPRPAVEQPPP 523
               R PPP     +PPP
Sbjct: 372 TSDSRGPPPTDPYGRPPP 389



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 34/109 (31%), Positives = 37/109 (33%), Gaps = 14/109 (12%)

Query: 509 GRAPPPRPAVEQPPPKVYVTRVR-----PGQRASPRAPAPRAPWPPFPGVFLHPRPLPRV 563
           G+A PP  +     P+    R R     PG    P    P  P PPFP     PRP    
Sbjct: 184 GKAGPPGGSSRAAFPQGGRGRGRFPGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRP---- 239

Query: 564 QLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAP 612
               P  PP P G   G P   Q  PP  A     G       L P  P
Sbjct: 240 ----PLGPPGPPG-PPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQP 283



 Score = 30.4 bits (67), Expect = 9.1
 Identities = 33/125 (26%), Positives = 37/125 (29%), Gaps = 26/125 (20%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFL 508
           P     P  GP  P    P  PG     P PPRP                    PL   L
Sbjct: 299 PVPGYGPPPGPPPPQQGPPPPPG-----PFPPRP------------------PGPLGPPL 335

Query: 509 GRAPPPR---PAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQL 565
             APPP    P    PPP  +V         +   P   +  PP    +  P P  R   
Sbjct: 336 TLAPPPHLPGPPPGAPPPAPHVNPAFFPPPTNSGMPTSDSRGPPPTDPYGRPPPYDRGDY 395

Query: 566 RAPPR 570
             P R
Sbjct: 396 GPPGR 400


>gi|4826998 splicing factor proline/glutamine rich (polypyrimidine
           tract binding protein associated) [Homo sapiens]
          Length = 707

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 84/300 (28%), Positives = 103/300 (34%), Gaps = 38/300 (12%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFL 508
           P    P +SGP+ P P  P        PP  P P+    P H            P P   
Sbjct: 46  PMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQ--PPPHQPP-------PHPQPHQQ 96

Query: 509 GRAPPP-----RPAVEQPP-PKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPR 562
            + PPP     +P V Q P P   V    P   ++P A  P +  PP  G    P P P 
Sbjct: 97  QQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPA 156

Query: 563 VQLR---APPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLS 619
           V      APP  P   G  T  PQA  P PP    A  G   G  +  GP  P     + 
Sbjct: 157 VTSAPPGAPPPTPPSSGVPTTPPQAGGPPPP--PAAVPGPGPGPKQGPGPGGPK-GGKMP 213

Query: 620 SEARPVTSFLSLSQVSG-PQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRWRED 678
              +P      LS   G P+ P  G  E  G     P             GP  G   E+
Sbjct: 214 GGPKP-GGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGP--GGRSEE 270

Query: 679 AIDWQRTFSVGAVDFELLRSDWNDL---RCNV-SGNLQLPEAEAVDVTAQYMERLNARHG 734
            I     F     +  LLR         RC +  GNL        D+T    +RL A++G
Sbjct: 271 KISDSEGFK---ANLSLLRRPGEKTYTQRCRLFVGNL------PADITEDEFKRLFAKYG 321



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 31/119 (26%), Positives = 45/119 (37%), Gaps = 5/119 (4%)

Query: 521 PPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPH--GRR 578
           PPP + + + R      P    P+ P PP P      +P P+   + PP+ P PH     
Sbjct: 34  PPPGMGLNQNRGPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQ---QPPPQQPPPHQPPPH 90

Query: 579 TGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGP 637
               Q  QP PP +  +     +G     G  +    S+ +  A P TS        GP
Sbjct: 91  PQPHQQQQPPPPPQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGP 149


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 53/224 (23%), Positives = 66/224 (29%), Gaps = 33/224 (14%)

Query: 454  PPRSGPQSPAPAAPAQPGATLAPP----------TPPRPRDGGTPRHSRALSWAARAARP 503
            PP+  P +PA   P+  G    PP          TPP P+ G      +       A  P
Sbjct: 1144 PPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPP 1203

Query: 504  LPLFLGRAPPPRPAVEQP---PPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPL 560
             P      P P+ A   P   PP        P  + +P  PA   P P        P+  
Sbjct: 1204 SPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGA 1263

Query: 561  PRVQLRAPPR--------------------PPRPHGRRTGGPQATQPRPPARAQATQGGR 600
            P      PP                     PP P G     P    P PPA    +  G 
Sbjct: 1264 PTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGS 1323

Query: 601  EGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGPQLPGEGE 644
             G     G   P   +  S +  P     + S   GP  P   E
Sbjct: 1324 PGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKE 1367



 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 61/208 (29%), Positives = 75/208 (36%), Gaps = 28/208 (13%)

Query: 454  PPRSGPQSPAPAAPAQPGATLAPP----------TPPRPRDGGTPRHSRALSWAARAARP 503
            PP+  P  PA   P+  G    PP          TPP P+ G      +       A  P
Sbjct: 1259 PPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPP 1318

Query: 504  LPLFLGRAPPPR-----PAVEQPPPKVYVT--RVRPGQRASPRAPAPR-APWPP--FPGV 553
             P      PPP+     PAV  P PK   T     P  +  P  P+ +  P PP   P  
Sbjct: 1319 SPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSH 1378

Query: 554  FLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQAR-TLGPAAP 612
               P   P    R  P  P P G  T    A  P  P +A AT   REG A  + G   P
Sbjct: 1379 KGGPAMTPPSPKRG-PAIPSPKGDPTS--PAVIPLSPKKAPATPVTREGAATPSKGDLTP 1435

Query: 613  TVDSNLSSEARPVTSFLSLSQVSGPQLP 640
               + +S +  P TS    +   GP  P
Sbjct: 1436 PAVTPVSLKKAPATS----APKGGPATP 1459



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 77/279 (27%), Positives = 98/279 (35%), Gaps = 66/279 (23%)

Query: 449  PTEAAPP--RSGPQSPAP-AAPAQPGATLAPPTP-------PRPRDGGTPRHSRALS-WA 497
            P  A PP  + GP +P+P  AP  P  T  PP+P       P P+   TP  +   S   
Sbjct: 988  PPAATPPSPKGGPATPSPKGAPTPPAVT--PPSPKGSPAATPFPKGASTPPAATPPSPKG 1045

Query: 498  ARAARPLPLFLGRAPPPRPAVEQPPPK------------VYVTRVRPGQRASPRAPAPR- 544
            + AA PLP    +  P  PA   P PK                   P  +  P  P+P+ 
Sbjct: 1046 SPAATPLP----KGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKG 1101

Query: 545  -----APWPPFP--GVFLHP-RPLPRVQLRAPPRP------PRPHGRRTGGPQATQPRP- 589
                 A  PP P  G+   P +  P      PP P      P P G  T  P AT P P 
Sbjct: 1102 APMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPT-TPAATPPSPK 1160

Query: 590  -----------PARAQATQGGREGQARTLGP-AAPTVDSNLSSEARPVTSFLSLSQVSGP 637
                       P    AT    +G   T  P  APT  +  ++   P     + S    P
Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPA--ATPPSPKGGLATPSPKGAP 1218

Query: 638  QLPGEGEEEEEG-----EDDGAPGDEAASEDSEEAAGPA 671
              P       +G        GAP   AA+  S +  GPA
Sbjct: 1219 TTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK-GGPA 1256



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 71/257 (27%), Positives = 94/257 (36%), Gaps = 39/257 (15%)

Query: 445  DSLEPTEAAPPRSGPQSPAPAA--PAQP-GATLAP---PTP-----PRPRDGGT---PRH 490
            DS   T +  P S   +P P+A  P  P G TL P   PTP     P P++G     P+ 
Sbjct: 848  DSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQ 907

Query: 491  SRALSWAARA-----ARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRA 545
            + ALS  + +     A P P  +  +P P+ A   P       +  P   +   AP P A
Sbjct: 908  APALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPA 967

Query: 546  PWPPFP---GVFLHPRPLPRVQLRAPPRP------PRPHGRRTGGPQATQPRPPARAQAT 596
              PP P        P+  P      PP P      P P G  T  P  T P P     AT
Sbjct: 968  ATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPT-PPAVTPPSPKGSPAAT 1026

Query: 597  QGGREGQARTLGPAAPTVDSNLSSEARPVTSFLSLSQVSGP--QLPGEGEEEEEGEDDGA 654
               +       G + P   +  S +  P  + L     + P   LP            GA
Sbjct: 1027 PFPK-------GASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGA 1079

Query: 655  PGDEAASEDSEEAAGPA 671
            P   AA+  S +  GPA
Sbjct: 1080 PTPPAATPPSPK-GGPA 1095



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 63/222 (28%), Positives = 79/222 (35%), Gaps = 25/222 (11%)

Query: 455  PRSGPQSPAP-AAPAQPGATLAPPTP------PRPRDGGTPRHSRALSWAARAARPLPLF 507
            P+  P SP+P  AP  P AT  PP+P      P P+   TP  +   S     A P P  
Sbjct: 927  PKGIPASPSPKGAPTPPAAT--PPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSP-- 982

Query: 508  LGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRA 567
              +  P  PA   P PK       P   +   AP P A  PP P       P P+     
Sbjct: 983  --KGAPTPPAATPPSPKG-----GPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTP 1035

Query: 568  P-PRPPRPHG--RRTGGPQATQPRPPARAQATQGGREGQARTLGPAAP--TVDSNLSSEA 622
            P   PP P G    T  P+     P A   + +GG    +    P  P  T  S     A
Sbjct: 1036 PAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPA 1095

Query: 623  RPVTSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDS 664
             P      +   + P  P  G      +  GAP   AA+  S
Sbjct: 1096 TPSPKGAPMPPAATPPSPKGGLATPPHK--GAPTTPAATPPS 1135



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 45/177 (25%), Positives = 61/177 (34%), Gaps = 28/177 (15%)

Query: 453  APPRSGPQSPAPAAPAQPGATLAPP----------TPPRPRDGGTPRHSRALSWAARAAR 502
            +PP+  P  PA   P+  G+   PP          TPP P+  GTP     L     +++
Sbjct: 1304 SPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPK--GTP----TLPATTPSSK 1357

Query: 503  PLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPR 562
              P        P P    P  K       P  +  P  P+P+   P  P V      +P 
Sbjct: 1358 GGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGD-PTSPAV------IPL 1410

Query: 563  VQLRAPPRPPRPHGRRTGG-----PQATQPRPPARAQATQGGREGQARTLGPAAPTV 614
               +AP  P    G  T       P A  P    +A AT   + G A       PT+
Sbjct: 1411 SPKKAPATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTL 1467



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 54/195 (27%), Positives = 67/195 (34%), Gaps = 16/195 (8%)

Query: 453  APPRSGPQSPAPAAPAQPG-ATLAPPTPPRPRDGGTPRHSRALSWAARA-ARPLPLFLGR 510
            AP  S P+   PA P+  G  TL   TPP P++   P+     S   +A A P P+    
Sbjct: 1446 APATSAPKG-GPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPM---- 1500

Query: 511  APPPRPAVEQPPPKVYVTRVRPGQRASPRAP-----APRAPWPPFPGVFLHPRPLPRVQL 565
              P  PAV    PK       P  R  P AP     + + P    P   L P  +     
Sbjct: 1501 GAPTLPAVIPSSPK--EVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMTVPSP 1558

Query: 566  RAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPV 625
            +  P  P P              PPA   +T  G       L P  P V S    EA   
Sbjct: 1559 KKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIP--PAVTSPSPKEAPTP 1616

Query: 626  TSFLSLSQVSGPQLP 640
             +    S   GP  P
Sbjct: 1617 PAVTPPSPEKGPATP 1631



 Score = 34.7 bits (78), Expect = 0.48
 Identities = 48/180 (26%), Positives = 65/180 (36%), Gaps = 35/180 (19%)

Query: 446  SLEPTEA-APPRSGPQSP--APAAPAQPGATLAPP-TPPRPRDGGTPRHSRALSWAA--- 498
            S  P EA  PP   P SP   PA PA  G   +PP TP   +D  T   S      A   
Sbjct: 1607 SPSPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVP 1666

Query: 499  RAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPR 558
            +A++ LP             ++ P  +    V P   ++P   AP    P          
Sbjct: 1667 QASKGLP------------AKKGPTALKEVLVAPAPESTPIITAPTRKGP---------- 1704

Query: 559  PLPRVQLRAPPRPPRPHGRR-TGGPQAT-QPRPPARAQ----ATQGGREGQARTLGPAAP 612
               +    +PP  P P  +  + GP +T  P P    Q     T  G++      GP AP
Sbjct: 1705 QTKKSSATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAP 1764



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 54/207 (26%), Positives = 72/207 (34%), Gaps = 35/207 (16%)

Query: 441 GELLDSLEPTEAAPPRSG------PQSPA---PAAPAQPGATLAPPTPPRPRDGGTPRHS 491
           GE  +++  TE   P+        P S A    AA  QPG TL PP  P P+        
Sbjct: 3   GEATETVPATEQELPQPQAETAVLPMSSALSVTAALGQPGPTLPPPCSPAPQ-------- 54

Query: 492 RALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPA--PRAPWPP 549
           +    AA  A P P     A  P   +E P P+       P    +P AP   P    PP
Sbjct: 55  QCPLSAANQASPFPSPSTIASTP---LEVPFPQSSSGTALP-LGTAPEAPTFLPNLIGPP 110

Query: 550 F-PGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQ----------PRPPARAQATQG 598
             P       P+    L+  P    P       P + Q            PP+ A A  G
Sbjct: 111 ISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESG 170

Query: 599 GREGQARTLGPAAPTVDSN-LSSEARP 624
                +  + P+ P  + N + SE  P
Sbjct: 171 SVITLSAPIAPSEPKTNLNKVPSEVVP 197



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 58/218 (26%), Positives = 76/218 (34%), Gaps = 44/218 (20%)

Query: 448  EPT-EAAPPRSGPQSP-------------APAAPAQPGA-TLAPPTPPRPRD-GGTP--R 489
            +PT  A  P S  + P             APA PA  GA TL    P  P++   TP  R
Sbjct: 1464 DPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSR 1523

Query: 490  HSRALSWAARAARPLPLFLGRAP-----PPRPAVEQP--PPKVYVTRVRPGQRASPRAPA 542
                   A   ++  P  L  AP     PP   V  P   P +   +  P   +S  A +
Sbjct: 1524 RDPIAPTATLLSKKTPATL--APKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASS 1581

Query: 543  PRAPWP------PFPGVFLHP----RPLPRVQLRAPP--RPPRPH-GRRTGGPQATQPRP 589
            P A  P      P P   L P     P P+ +   PP   PP P  G  T  P+ T   P
Sbjct: 1582 PPAVTPSTYKGAPSPKELLIPPAVTSPSPK-EAPTPPAVTPPSPEKGPATPAPKGTPTSP 1640

Query: 590  PARAQATQGGREGQART---LGPAAPTVDSNLSSEARP 624
            P    + +      A     +G   P     L ++  P
Sbjct: 1641 PVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGP 1678



 Score = 32.0 bits (71), Expect = 3.1
 Identities = 27/85 (31%), Positives = 34/85 (40%), Gaps = 16/85 (18%)

Query: 449  PTEAAPPRSG--PQSP-----APAAPAQPGAT--LAPPTPPRPRDGGTPRHSRALSWAAR 499
            P    PP+    P SP     +P+ P  P     L P  PP P  GG P  S  ++    
Sbjct: 1806 PVPTLPPKQQFLPSSPGLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVN---- 1861

Query: 500  AARPLPLFLGRAPPPRPAVEQPPPK 524
               P P   G  P P P+ +QP  K
Sbjct: 1862 --MPTPKSAG-IPVPTPSAKQPVTK 1883



 Score = 31.2 bits (69), Expect = 5.3
 Identities = 50/201 (24%), Positives = 61/201 (30%), Gaps = 44/201 (21%)

Query: 446  SLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLP 505
            +L P EA  P +         PA P    AP TP        P  + +    A + + L 
Sbjct: 1541 TLAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELL 1600

Query: 506  LFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQL 565
            +         PAV  P PK               AP P A  PP P              
Sbjct: 1601 I--------PPAVTSPSPK--------------EAPTPPAVTPPSP-------------- 1624

Query: 566  RAPPRPPRPHGRRTGGPQA-----TQPRPPARAQATQGGREGQARTLGPA--APT-VDSN 617
               P  P P G  T  P         P  PA      G    QA    PA   PT +   
Sbjct: 1625 EKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEV 1684

Query: 618  LSSEARPVTSFLSLSQVSGPQ 638
            L + A   T  ++     GPQ
Sbjct: 1685 LVAPAPESTPIITAPTRKGPQ 1705


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 69/241 (28%), Positives = 85/241 (35%), Gaps = 45/241 (18%)

Query: 453 APPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAP 512
           +PP   P SP  + P  P AT  PP+   P     P        A+    P      +AP
Sbjct: 445 SPPVQAPFSPPASPPVSPSAT--PPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 502

Query: 513 PPRPA----VEQPPPKVYVTRVRPGQRASPRAPAP---RAPWPPFPGVFLHPRPLPRVQ- 564
           PP  A    + +PPP+       P  +A P  PA    +AP+ P   + + P   P  Q 
Sbjct: 503 PPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQA 562

Query: 565 --------LRAPPRPPRPHGRRTGGPQATQP-RPPARAQATQGGREGQARTLGPAAPTVD 615
                   L+ PP PP         P    P RPP     T          L P  P   
Sbjct: 563 PPVLAAPLLQVPPSPP-------ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPP 615

Query: 616 SNLSSEARPVTSFLSLSQVSGPQLPGEGE------EEEEGEDDGAPGDEAAS--EDSEEA 667
           S   S           S +SGP L G         EE  G D G  G  AAS   D+E A
Sbjct: 616 SRSPS-----------STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELA 664

Query: 668 A 668
           A
Sbjct: 665 A 665



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 59/207 (28%), Positives = 73/207 (35%), Gaps = 45/207 (21%)

Query: 444 LDSLEPTEAAPPRS------GPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWA 497
           L +L P +  PPR       GP S +P A   P A L    PP       P    + S  
Sbjct: 277 LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPT-----LPATPHSSSLT 331

Query: 498 ARAARPLPLF--LGRAPPPRPAVEQPP-------------PKVYVTR-VRPGQRASPRA- 540
            + A PLPL      APP    +  PP             P +  T    P    SP A 
Sbjct: 332 CQLATPLPLAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLAT 391

Query: 541 PAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGR 600
           P P+AP    P + L P       L+APP PP         P +    P  +A       
Sbjct: 392 PPPQAP----PALALPP-------LQAPPSPP------ASPPLSPLATPSPQAPNALAVH 434

Query: 601 EGQARTLGPAAPTVDSNLSSEARPVTS 627
             QA    P +P V +  S  A P  S
Sbjct: 435 LLQAPFSPPPSPPVQAPFSPPASPPVS 461



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 40/129 (31%), Positives = 50/129 (38%), Gaps = 9/129 (6%)

Query: 454 PPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRH--SRALSWAARA----ARPLPLF 507
           PP  GP+    +A        +P    RP  GG  +   SR+LS +A      AR  P  
Sbjct: 200 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS- 258

Query: 508 LGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRA 567
             R  P  PA    P    +  +RP Q   PR  A  A  P        P P   +Q +A
Sbjct: 259 -ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQA 317

Query: 568 PPR-PPRPH 575
           PP  P  PH
Sbjct: 318 PPTLPATPH 326



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 54/188 (28%), Positives = 67/188 (35%), Gaps = 20/188 (10%)

Query: 450 TEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGT---PRHSRALSWAARAARPLPL 506
           + +A P S P    P+A   P A  A P+ P+P+       P+ +     AA A  PL  
Sbjct: 243 SSSATPLSSPARSGPSARGTPRAP-AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSS 301

Query: 507 FLGRAPPPRPAVE-QPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQL 565
                P P  A++ Q PP +  T            P P AP  P     L   P P    
Sbjct: 302 SPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSP---- 357

Query: 566 RAPPRPPRPHGRRTGGP--QATQ---PRPPARAQATQGGREGQARTL----GPAAPTVDS 616
             P  PP       G P  QAT    P PP    AT   +   A  L     P +P    
Sbjct: 358 --PATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPPLQAPPSPPASP 415

Query: 617 NLSSEARP 624
            LS  A P
Sbjct: 416 PLSPLATP 423



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 53/194 (27%), Positives = 68/194 (35%), Gaps = 39/194 (20%)

Query: 455 PRSGP--------QSPAPAAPAQPGATLAPP---TPPRP-----RDGGTPRHSRALSWAA 498
           PR+GP        ++PA   PA      APP   T P P     R  GT R         
Sbjct: 75  PRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGL 134

Query: 499 RAARPLPLFLGRAP--PPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFP----- 551
           R +    +  G+A   P R A+              G R     P P  P P        
Sbjct: 135 RISAEETVARGKATEAPKRSALSA------------GARRDTSGPTPGTPSPAMARRSRA 182

Query: 552 -GVFLH-PRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGP 609
            G  +  PRP P  + R P   PR           T+P P AR + + GG  G  R    
Sbjct: 183 AGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG--GLQRPASR 240

Query: 610 AAPTVDSNLSSEAR 623
           +  +  + LSS AR
Sbjct: 241 SLSSSATPLSSPAR 254



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 77/302 (25%), Positives = 98/302 (32%), Gaps = 81/302 (26%)

Query: 444 LDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTP-----PRPRDGGTPRHSRALSWAA 498
           L +L    A+ P   P SP+ + P  P AT  P  P     P  +   +P  S  L    
Sbjct: 528 LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 587

Query: 499 RAARPLP--------LFLGRAPPPRPAVEQPPPKVYVTRVRPGQRAS------------- 537
           R   P P        L L  AP P P   + P          G  +S             
Sbjct: 588 RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 647

Query: 538 -PRAPAPRAPWPPFPGVFLHPR-----PLPRVQLRAPPRPPRPHGRRTG----------- 580
            P   A  +P P       HP      P P +  R  P  P P    TG           
Sbjct: 648 GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY 707

Query: 581 ---GPQATQPRP----PARAQATQGGREG-------------QAR----TLGPAAPTVDS 616
              GP++  P P    P  +  T GG+               QAR     LG    +V  
Sbjct: 708 ETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQ 767

Query: 617 NLSSEARPVTSFLSLSQ-VSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRW 675
           +L S     T  L+ ++  +G    G G  E  G   GA    AA  D+E      LGRW
Sbjct: 768 HLLSR----TLLLAAAEGAAGGSGGGPGGAEGGGVTGGA---RAALSDAE------LGRW 814

Query: 676 RE 677
            E
Sbjct: 815 AE 816



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 60/234 (25%), Positives = 85/234 (36%), Gaps = 31/234 (13%)

Query: 456 RSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLF-----LGR 510
           ++G  +  PAA A    T  PP  PRP    TP   R L  AA A    PL      +G 
Sbjct: 9   KAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLG-AAGAVGRKPLAERAGGIGG 67

Query: 511 APPPRPAVEQPPPKVYVTRVR-PGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPP 569
           A  P  A    P +   T  R P  R        RAP    P     P P+      +  
Sbjct: 68  ATIPESAPRAGPTRSAGTSSRNPASRPPASGRGERAP----PAKNTSPGPVSSPGRASGT 123

Query: 570 RPPRPHGRRTGGPQATQPRPPARAQATQGGRE------GQARTLGPAAPTVDSNLSSEAR 623
             P P G++  G + +     AR +AT+  +        +  T GP   T    ++  +R
Sbjct: 124 TRPGPLGQK--GLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSR 181

Query: 624 PVTSFLSL---SQVSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGR 674
              + + L   +  + P+ P EG  +            +ASE S     PA  R
Sbjct: 182 AAGTEVGLPRPAPSARPRPPTEGPRKSV---------SSASEHSTTEPSPAARR 226


>gi|85815829 SH3-domain binding protein 1 [Homo sapiens]
          Length = 701

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 58/192 (30%), Positives = 75/192 (39%), Gaps = 37/192 (19%)

Query: 435 LDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLA---------PPTPPRPRDG 485
           L D     L     P+ A P  +   +PAPA    P   LA            PPRP   
Sbjct: 486 LQDTVSDRLASEELPSTAVPTPATTPAPAPAPAPAPAPALASAATKERTESEVPPRP--- 542

Query: 486 GTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRA 545
            +P+ +R+    A     +     R  P RP +  PPP+V       G R+SP AP    
Sbjct: 543 ASPKVTRSPPETAAPVEDMARRTKRPAPARPTM--PPPQV------SGSRSSPPAP---- 590

Query: 546 PWPPFPGVFLHPRPLPR----VQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGRE 601
           P PP  G    P+ LPR      LRAP  PP         P    P  PAR Q+ +    
Sbjct: 591 PLPPGSGSPGTPQALPRRLVGSSLRAPTVPP---------PLPPTPPQPARRQSRRSPAS 641

Query: 602 GQARTLGPAAPT 613
               + GPA+P+
Sbjct: 642 PSPASPGPASPS 653



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 50/160 (31%), Positives = 62/160 (38%), Gaps = 23/160 (14%)

Query: 449 PTEAAPPRS---GPQSPAPAAPAQP-----GATLAPPTPPRPRDGGTPRHSRALSWAARA 500
           P  AAP        + PAPA P  P     G+  +PP PP P   G+P   +AL      
Sbjct: 552 PETAAPVEDMARRTKRPAPARPTMPPPQVSGSRSSPPAPPLPPGSGSPGTPQAL------ 605

Query: 501 ARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPL 560
            R L     RAP   P +   PP+      R   R SP +P+P +P P  P       P 
Sbjct: 606 PRRLVGSSLRAPTVPPPLPPTPPQ----PARRQSRRSPASPSPASPGPASPSPVSLSNP- 660

Query: 561 PRVQLRAPP----RPPRPHGRRTGGPQATQPRPPARAQAT 596
            +V L A       P    G  T      QPRP + A  T
Sbjct: 661 AQVDLGAATAEGGAPEAISGVPTPPAIPPQPRPRSLASET 700


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 71/230 (30%), Positives = 80/230 (34%), Gaps = 46/230 (20%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFL 508
           P+ AAPP   P SP  + P  P AT  P  PP       P  +  L  A    +  P   
Sbjct: 433 PSLAAPPLQVPPSPPASPPMSPSATPPPQAPP-------PLAAPPLQLAKPPPQAPPAL- 484

Query: 509 GRAPPPRPAVEQPPPKVYVTRVRPGQRA-SPRAPAPRAPWPPFPGVFLHPRPLPRVQLRA 567
             A PP  A+  PP         PGQ   SP A  P +P    P     P  L    L+ 
Sbjct: 485 --ATPPLQALPSPPASF------PGQAPFSPSASLPMSPLATPPP--QAPPVLAAPLLQV 534

Query: 568 PPRPPRPHGRRTGGPQATQP-RPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVT 626
           PP PP         P    P RPP     T          L P  P   S   S      
Sbjct: 535 PPSPP-------ASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPS------ 581

Query: 627 SFLSLSQVSGPQLPGEGE------EEEEGEDDGAPGDEAAS--EDSEEAA 668
                S +SGP L G         EE  G D G  G  AAS   D+E AA
Sbjct: 582 -----STLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA 626



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 56/196 (28%), Positives = 73/196 (37%), Gaps = 20/196 (10%)

Query: 444 LDSLEPTEAAPPRS------GPQSPAPAAPAQPGATLAPPTPPR----PRDGGTPRHSRA 493
           L +L P +  PPR       GP S +P A   P A  +P  PP     P    TP     
Sbjct: 268 LQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQAT 327

Query: 494 LSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPA--PRAPW-PPF 550
            S  +   +    FL    PP   +  PPP+       P  +A P  PA  P +P   P 
Sbjct: 328 TSLGSPTLQATHSFL--PSPPLSPLATPPPQAPPALALPPLQAPPSPPASPPLSPLATPS 385

Query: 551 PGVFLHPRPLPRVQLRAP-PRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLG- 608
           P     P  L    L+AP   PP P  +    P A+ P  P+    +Q      A  L  
Sbjct: 386 PQA---PNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQV 442

Query: 609 PAAPTVDSNLSSEARP 624
           P +P     +S  A P
Sbjct: 443 PPSPPASPPMSPSATP 458



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 57/195 (29%), Positives = 75/195 (38%), Gaps = 21/195 (10%)

Query: 454 PPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRH--SRALSWAARA----ARPLPLF 507
           PP  GP+    +A        +P    RP  GG  +   SR+LS +A      AR  P  
Sbjct: 191 PPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPS- 249

Query: 508 LGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRA 567
             R  P  PA    P    +  +RP Q   PR  A  A  P      L   PL      A
Sbjct: 250 -ARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGP------LSSSPLATPSPSA 302

Query: 568 PPRPPRPHGRRT-GGPQATQPRPPARAQATQGGREGQA-RTLGPAAPTVDSNLSSEARPV 625
           PP P  P   +T   P AT   PP++A  + G    QA  +  P+ P   S L++     
Sbjct: 303 PPSPSAPPSLQTLPSPPAT---PPSQATTSLGSPTLQATHSFLPSPPL--SPLATPPPQA 357

Query: 626 TSFLSLSQVSGPQLP 640
              L+L  +  P  P
Sbjct: 358 PPALALPPLQAPPSP 372



 Score = 39.7 bits (91), Expect = 0.015
 Identities = 77/302 (25%), Positives = 98/302 (32%), Gaps = 81/302 (26%)

Query: 444 LDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTP-----PRPRDGGTPRHSRALSWAA 498
           L +L    A+ P   P SP+ + P  P AT  P  P     P  +   +P  S  L    
Sbjct: 489 LQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 548

Query: 499 RAARPLP--------LFLGRAPPPRPAVEQPPPKVYVTRVRPGQRAS------------- 537
           R   P P        L L  AP P P   + P          G  +S             
Sbjct: 549 RPPTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDS 608

Query: 538 -PRAPAPRAPWPPFPGVFLHPR-----PLPRVQLRAPPRPPRPHGRRTG----------- 580
            P   A  +P P       HP      P P +  R  P  P P    TG           
Sbjct: 609 GPEGGAAASPPPDAELAACHPAAWSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIY 668

Query: 581 ---GPQATQPRP----PARAQATQGGREG-------------QAR----TLGPAAPTVDS 616
              GP++  P P    P  +  T GG+               QAR     LG    +V  
Sbjct: 669 ETEGPESATPAPGALDPGPSPGTSGGKAAAGAGAGASSRSPKQARLGELPLGALQASVVQ 728

Query: 617 NLSSEARPVTSFLSLSQ-VSGPQLPGEGEEEEEGEDDGAPGDEAASEDSEEAAGPALGRW 675
           +L S     T  L+ ++  +G    G G  E  G   GA    AA  D+E      LGRW
Sbjct: 729 HLLSR----TLLLAAAEGAAGGSGGGPGGAEGGGVTGGA---RAALSDAE------LGRW 775

Query: 676 RE 677
            E
Sbjct: 776 AE 777



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 49/191 (25%), Positives = 64/191 (33%), Gaps = 23/191 (12%)

Query: 451 EAAPPRSGPQSPAPAAPAQPGATLAPPTPPR-----PRDGGTPRHSRALSWAARAARPLP 505
           E A    G   P  A  A P  T  PP   R     P    +P    +   A+   RP P
Sbjct: 60  ERAGGIGGATIPESAPRAGPTRTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGP 119

Query: 506 L------FLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFP------GV 553
           L              R    + P +   + +  G R     P P  P P         G 
Sbjct: 120 LGQKGLRISAEETVARGKATEAPKR---SALSAGARRDTSGPTPGTPSPAMARRSRAAGT 176

Query: 554 FLH-PRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAP 612
            +  PRP P  + R P   PR           T+P P AR + + GG  G  R    +  
Sbjct: 177 EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGG--GLQRPASRSLS 234

Query: 613 TVDSNLSSEAR 623
           +  + LSS AR
Sbjct: 235 SSATPLSSPAR 245



 Score = 37.0 bits (84), Expect = 0.097
 Identities = 48/193 (24%), Positives = 63/193 (32%), Gaps = 19/193 (9%)

Query: 450 TEAAPPRSGPQSPAPAAPAQPGATLAPPTPP-------RPRDGGTPRHSRALSWAARAAR 502
           + +A P S P    P+A   P A   P  P        RP     PR   A +    ++ 
Sbjct: 234 SSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSS 293

Query: 503 PLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPR 562
           PL      APP   A    PP +      P    S    +  +P       FL   PL  
Sbjct: 294 PLATPSPSAPPSPSA----PPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 349

Query: 563 VQLRAPPRPPR---PHGRRTGGPQATQPRPPARAQATQGGRE-----GQARTLGPAAPTV 614
           +    P  PP    P  +    P A+ P  P    + Q          QA    P +P V
Sbjct: 350 LATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPV 409

Query: 615 DSNLSSEARPVTS 627
            +  S  A P  S
Sbjct: 410 QAPFSPPASPPVS 422



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 52/191 (27%), Positives = 63/191 (32%), Gaps = 39/191 (20%)

Query: 456 RSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAAR------------- 502
           ++G  +  PAA A    T  PP  PRP    TP   R L  A    R             
Sbjct: 9   KAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGA 68

Query: 503 PLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPR 562
            +P    RA P R    +PP      R  P +  SP   +     P        P PL +
Sbjct: 69  TIPESAPRAGPTR--TSRPPASGRGERAPPAKNTSPGPVSS----PGRASGTTRPGPLGQ 122

Query: 563 VQLR--------------APPRPPRPHGRR--TGGPQATQPRPP----ARAQATQGGREG 602
             LR              AP R     G R  T GP    P P     +RA  T+ G   
Sbjct: 123 KGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPR 182

Query: 603 QARTLGPAAPT 613
            A +  P  PT
Sbjct: 183 PAPSARPRPPT 193


>gi|23592228 extraembryonic, spermatogenesis, homeobox 1-like [Homo
           sapiens]
          Length = 406

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 50/137 (36%), Positives = 59/137 (43%), Gaps = 13/137 (9%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRH---SRALSWAARAARPLP 505
           P    PPR       P AP  PG+ +AP  PP PR    P     +    W   A  P+P
Sbjct: 257 PMVPMPPRPPIAPMPPMAPVPPGSRMAP-VPPGPRMAPVPPWPPMAPVPPWPPMA--PVP 313

Query: 506 LFLGRAP-PPRPAVEQPPPKVYVTRVRPGQRASPRAPA-PRAPWPPFPGVFLHPRPLPRV 563
                AP PP P + + PP   + RV PG   +P  P  P AP PP P +     PLP  
Sbjct: 314 TGPPMAPVPPGPPMARVPPGPPMARVPPGPPMAPLPPGPPMAPLPPGPPM----APLPPG 369

Query: 564 QLRAPPRPPRPHGRRTG 580
              A P PPR H   TG
Sbjct: 370 PPMA-PLPPRSHVPHTG 385



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 45/151 (29%), Positives = 53/151 (35%), Gaps = 48/151 (31%)

Query: 498 ARAARPLPLFLGRA------------------------------PPPRPAVEQPP----- 522
           A  A PL +FLG A                              PP  P V  PP     
Sbjct: 209 ADLAHPLDMFLGGAYYAAPALDPALCVHLVPQLPRPPVLPVPPMPPRPPMVPMPPRPPIA 268

Query: 523 PKVYVTRVRPGQRASPRAPAPR-APWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGG 581
           P   +  V PG R +P  P PR AP PP+P +     P+P      PP  P P    TG 
Sbjct: 269 PMPPMAPVPPGSRMAPVPPGPRMAPVPPWPPM----APVP----PWPPMAPVP----TGP 316

Query: 582 PQATQPRPPARAQATQGGREGQARTLGPAAP 612
           P A  P  P  A+   G    +     P AP
Sbjct: 317 PMAPVPPGPPMARVPPGPPMARVPPGPPMAP 347


>gi|21361376 splicing factor 3a, subunit 2 [Homo sapiens]
          Length = 464

 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 62/205 (30%), Positives = 71/205 (34%), Gaps = 21/205 (10%)

Query: 449 PTEAAPPRSGPQSPAPAAPAQPGATLAPPTP---PRPRDGGTPRHSRALSWAARAARPLP 505
           P   + P   P    P  P   G    PP P   P P  GG P      +  A +  P P
Sbjct: 218 PAPPSLPAGPPGVKRPPPPLMNGLPPRPPLPESLPPPPPGGLPLPPMPPTGPAPSGPPGP 277

Query: 506 LFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPA--PRAP--WPPFPGVF-----LH 556
               + PPP P V  P P V+     P     P AP   P AP   PP PGV      +H
Sbjct: 278 ---PQLPPPAPGVHPPAPVVH----PPASGVHPPAPGVHPPAPGVHPPAPGVHPPTSGVH 330

Query: 557 PRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDS 616
           P P P V   AP   P   G     P    P P      +  G   QA  + PAAP V  
Sbjct: 331 P-PAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPPS-AGVHPQAPGVHPAAPAVHP 388

Query: 617 NLSSEARPVTSFLSLSQVSGPQLPG 641
                  P       +    PQ PG
Sbjct: 389 QAPGVHPPAPGMHPQAPGVHPQPPG 413



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 61/186 (32%), Positives = 66/186 (35%), Gaps = 25/186 (13%)

Query: 443 LLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAAR 502
           L +SL P    PP   P  P P     P     PP  P P  G  P        A+    
Sbjct: 247 LPESLPPP---PPGGLPLPPMPPTGPAPSGPPGPPQLPPPAPGVHPPAPVVHPPASGVHP 303

Query: 503 PLPLFLGRAP---PPRPAVEQP-----PPKVYVTRVRPGQRASPRAPAPRAPW--PPFPG 552
           P P     AP   PP P V  P     PP   V    PG         P AP   PP PG
Sbjct: 304 PAPGVHPPAPGVHPPAPGVHPPTSGVHPPAPGVHPPAPGVHPPAPGVHPPAPGVHPPAPG 363

Query: 553 VFLHPRPLPRVQLRAP---PRPPRPHGRRTGGPQATQPRPPARAQATQG-GREGQARTLG 608
           V  HP P   V  +AP   P  P  H      PQA    PPA     Q  G   Q   + 
Sbjct: 364 V--HPPPSAGVHPQAPGVHPAAPAVH------PQAPGVHPPAPGMHPQAPGVHPQPPGVH 415

Query: 609 PAAPTV 614
           P+AP V
Sbjct: 416 PSAPGV 421


>gi|119395760 diaphanous 1 isoform 2 [Homo sapiens]
          Length = 1263

 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 55/169 (32%), Positives = 57/169 (33%), Gaps = 40/169 (23%)

Query: 446 SLEPTEAAPPRSG------PQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAAR 499
           S  P   APP  G      P  PAP     P     PP PP P  GG    S        
Sbjct: 569 SRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGT 628

Query: 500 AARPLPLFLGRA----PPPRP---------------AVEQPPPKVYVTRVRPGQRASPRA 540
           A  P P   G A    PPP P               A+  PPP        PG   S R 
Sbjct: 629 AISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPL-------PG---SARI 678

Query: 541 PAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRP 589
           P P  P P   G+   P PLP      PP PP P     GGP    P P
Sbjct: 679 PPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP-----GGPGIPPPPP 722



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 41/119 (34%), Positives = 46/119 (38%), Gaps = 19/119 (15%)

Query: 454 PPRSGPQSPAPAAPAQPG-ATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRA- 511
           PP  G     P  P  PG A + PP PP P + G P     L        P P   G   
Sbjct: 670 PPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGI 729

Query: 512 PPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPL--PRVQLRAP 568
           PPP P +  PPP  +   V            P AP  PF    L P+ L  P VQLR P
Sbjct: 730 PPPPPGMGMPPPPPFGFGV------------PAAPVLPFG---LTPKKLYKPEVQLRRP 773



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 41/120 (34%), Positives = 47/120 (39%), Gaps = 21/120 (17%)

Query: 454 PPRSGPQSPAPAAPAQ-PGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAP 512
           PP   P+     +P+  PG T  PP PP P     P     L  +A    P P   G A 
Sbjct: 644 PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAG 703

Query: 513 PPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPP 572
            P P    PPP        PG    P  P P    PPFPG    P P P + +  PP PP
Sbjct: 704 MPPP----PPP-------LPG---GPGIPPP----PPFPGGPGIPPPPPGMGM--PPPPP 743



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 45/149 (30%), Positives = 51/149 (34%), Gaps = 31/149 (20%)

Query: 467 PAQPGATLAPPTPPRPRDGGT---PRHSRALSWAARAARPLPLFLGRAPPPRP---AVEQ 520
           P+ P     PP PP P D GT   P  +   S       P P      PPP P    +  
Sbjct: 565 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP----PPPPPLPGGVCISS 620

Query: 521 PPPKVYVTRVRPGQRASPRAPAPRAPWPPFP-GVFL-------------HPRPLPRVQLR 566
           PP     T + P    S  A  P  P PP P GV +              P PLP     
Sbjct: 621 PPSLPGGTAISPPPPLSGDATIP--PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARI 678

Query: 567 APPRPPRPHGRRTGGPQATQPRPPARAQA 595
            PP PP P     G      P PP   +A
Sbjct: 679 PPPPPPLP-----GSAGIPPPPPPLPGEA 702


>gi|119395758 diaphanous 1 isoform 1 [Homo sapiens]
          Length = 1272

 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 55/169 (32%), Positives = 57/169 (33%), Gaps = 40/169 (23%)

Query: 446 SLEPTEAAPPRSG------PQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAAR 499
           S  P   APP  G      P  PAP     P     PP PP P  GG    S        
Sbjct: 578 SRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISSPPSLPGGT 637

Query: 500 AARPLPLFLGRA----PPPRP---------------AVEQPPPKVYVTRVRPGQRASPRA 540
           A  P P   G A    PPP P               A+  PPP        PG   S R 
Sbjct: 638 AISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPL-------PG---SARI 687

Query: 541 PAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRP 589
           P P  P P   G+   P PLP      PP PP P     GGP    P P
Sbjct: 688 PPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLP-----GGPGIPPPPP 731



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 41/119 (34%), Positives = 46/119 (38%), Gaps = 19/119 (15%)

Query: 454 PPRSGPQSPAPAAPAQPG-ATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRA- 511
           PP  G     P  P  PG A + PP PP P + G P     L        P P   G   
Sbjct: 679 PPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGI 738

Query: 512 PPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPL--PRVQLRAP 568
           PPP P +  PPP  +   V            P AP  PF    L P+ L  P VQLR P
Sbjct: 739 PPPPPGMGMPPPPPFGFGV------------PAAPVLPFG---LTPKKLYKPEVQLRRP 782



 Score = 45.4 bits (106), Expect = 3e-04
 Identities = 41/120 (34%), Positives = 47/120 (39%), Gaps = 21/120 (17%)

Query: 454 PPRSGPQSPAPAAPAQ-PGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAP 512
           PP   P+     +P+  PG T  PP PP P     P     L  +A    P P   G A 
Sbjct: 653 PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPLPGSAGIPPPPPPLPGEAG 712

Query: 513 PPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPP 572
            P P    PPP        PG    P  P P    PPFPG    P P P + +  PP PP
Sbjct: 713 MPPP----PPP-------LPG---GPGIPPP----PPFPGGPGIPPPPPGMGM--PPPPP 752



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 45/149 (30%), Positives = 51/149 (34%), Gaps = 31/149 (20%)

Query: 467 PAQPGATLAPPTPPRPRDGGT---PRHSRALSWAARAARPLPLFLGRAPPPRP---AVEQ 520
           P+ P     PP PP P D GT   P  +   S       P P      PPP P    +  
Sbjct: 574 PSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPP----PPPPPLPGGVCISS 629

Query: 521 PPPKVYVTRVRPGQRASPRAPAPRAPWPPFP-GVFL-------------HPRPLPRVQLR 566
           PP     T + P    S  A  P  P PP P GV +              P PLP     
Sbjct: 630 PPSLPGGTAISPPPPLSGDATIP--PPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARI 687

Query: 567 APPRPPRPHGRRTGGPQATQPRPPARAQA 595
            PP PP P     G      P PP   +A
Sbjct: 688 PPPPPPLP-----GSAGIPPPPPPLPGEA 711


>gi|117306167 proline-rich protein BstNI subfamily 3 precursor [Homo
           sapiens]
          Length = 309

 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 49/163 (30%), Positives = 60/163 (36%), Gaps = 19/163 (11%)

Query: 451 EAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGR 510
           E  PP+ G QS  P  P +PG    PP     +  G P H            P      +
Sbjct: 142 EGPPPQGGNQSQGP--PPRPGKPEGPPPQGGNQSQGPPPHPGK----PEGPPPQGGNQSQ 195

Query: 511 APPPRPAVEQPPPKVYVTRV-----RPGQRASPRAPAPRAPW--PPFPGVFLHPRPLPRV 563
            PPPRP   + PP     +      RPG+   P +     P   PP PG    P P    
Sbjct: 196 GPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNKPQGPPPHPGKPQGPPPQEGN 255

Query: 564 QLRAPPRPPRPHGRRTGGPQATQPRPPARAQ------ATQGGR 600
           + + PP P RP G    G    QP PP   +        QGGR
Sbjct: 256 KPQRPPPPGRPQGPPPPGGNPQQPLPPPAGKPQGPPPPPQGGR 298



 Score = 51.2 bits (121), Expect = 5e-06
 Identities = 56/191 (29%), Positives = 75/191 (39%), Gaps = 31/191 (16%)

Query: 451 EAAPPRSGPQSPAPAAPAQPGATLAPPT---------PPRPR--DGGTPRH-SRALSWAA 498
           E  PP+ G QS  P  P +PG    PP          PPRP   +G  P+  +++     
Sbjct: 58  EGRPPQGGNQSQGP--PPRPGKPEGPPPQGGNQSQGPPPRPGKPEGQPPQGGNQSQGPPP 115

Query: 499 RAARPL-PLFLG----RAPPPRPAVEQPPPKVYVTRVR--PGQRASPRAPAPRAPW---- 547
           R  +P  P   G    + PPPRP   + PP     + +  P +   P  P P+       
Sbjct: 116 RPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQG 175

Query: 548 -PPFPGVFLHPRPLPRVQLRAPP-RPPRPHGRRTGGPQATQPRPP----ARAQATQGGRE 601
            PP PG    P P    Q + PP RP +P G    G   +Q  PP         +QGG +
Sbjct: 176 PPPHPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNK 235

Query: 602 GQARTLGPAAP 612
            Q     P  P
Sbjct: 236 PQGPPPHPGKP 246



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 43/138 (31%), Positives = 50/138 (36%), Gaps = 20/138 (14%)

Query: 451 EAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGR 510
           E  PP+ G QS  P  P +PG    PP     +  G P                P    +
Sbjct: 184 EGPPPQGGNQSQGP--PPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPSQGGNKP----Q 237

Query: 511 APPPRPAVEQPPPKVYVTRVRPGQRASP-RAPAPRAPW--PPFPGVFLHPRPLPRVQLRA 567
            PPP P   Q PP        P +   P R P P  P   PP  G    P P P  + + 
Sbjct: 238 GPPPHPGKPQGPP--------PQEGNKPQRPPPPGRPQGPPPPGGNPQQPLPPPAGKPQG 289

Query: 568 PPRPP---RPHGRRTGGP 582
           PP PP   RPH    G P
Sbjct: 290 PPPPPQGGRPHRPPQGQP 307



 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 49/170 (28%), Positives = 57/170 (33%), Gaps = 38/170 (22%)

Query: 459 PQSPAPAAPAQPGATLAPPTPP--RPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPRP 516
           P+   P    QP  T  PP  P  RP  GG                       + PPPRP
Sbjct: 36  PEGRRPQGGNQPQRTPPPPGKPEGRPPQGGNQ--------------------SQGPPPRP 75

Query: 517 AV-EQPPPKVYVTRVRPGQRASPRAPAPRAPW--------PPFPGVFLHPRPLPRVQLRA 567
              E PPP+       P  R  P  P  + P         PP PG    P P    Q + 
Sbjct: 76  GKPEGPPPQGGNQSQGPPPR--PGKPEGQPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQG 133

Query: 568 PP-RPPRPHGRRTGGPQATQPRPP----ARAQATQGGREGQARTLGPAAP 612
           PP RP +P G    G   +Q  PP          QGG + Q     P  P
Sbjct: 134 PPPRPGKPEGPPPQGGNQSQGPPPRPGKPEGPPPQGGNQSQGPPPHPGKP 183


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 64/202 (31%), Positives = 70/202 (34%), Gaps = 54/202 (26%)

Query: 446 SLEPTEAAPPRSGPQSPAPAAPAQPG--ATLAPPTPPRPRDGGTP--------------- 488
           S  P  AA   +    PAPA PA+P   A LA    P P  G  P               
Sbjct: 136 SCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAA 195

Query: 489 ---RHSRALSWAARAARPLPLFLGRAPP-----PRPA----VEQPPPKVYVTRVRPGQRA 536
                S AL  +  AA P    +   P      P+PA    V Q PP V           
Sbjct: 196 QTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFV----------G 245

Query: 537 SPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPP-------RPHGRRTGGPQATQPRP 589
           +   PAP AP PP         P P     APP PP       RP G   G P A  P  
Sbjct: 246 AAAPPAPAAPSPP-------AAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAA-PAV 297

Query: 590 PARAQATQGGREGQARTLGPAA 611
           P  A A  GG  G A    PAA
Sbjct: 298 PPPAAAQNGGSAGAAPAPAPAA 319



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 63/220 (28%), Positives = 76/220 (34%), Gaps = 34/220 (15%)

Query: 448 EPTEAAPPR-SGPQS------PAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARA 500
           EP  A P + +GP +      P P     PG    P  P  P    T   S AL  +  A
Sbjct: 151 EPAPAGPAKPAGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHA 210

Query: 501 ARPLPLFLGRAPP-----PRPA-----VEQPPPKVYVTRVRPGQRASPRAPAPRAPW--- 547
           A P    +   P      P+PA     ++ PP         P   + P APAP AP    
Sbjct: 211 AAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAP 270

Query: 548 ---PPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQA 604
              PP P     P   P     A P  P P   + GG     P P   A    GG  G +
Sbjct: 271 PPPPPAPATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAA----GGPAGVS 326

Query: 605 RTLGP----AAPTVDSNLSSEARPVTSFLSLSQ---VSGP 637
              GP    AAP       S  R V +    +Q    SGP
Sbjct: 327 GQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGP 366



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 47/160 (29%), Positives = 55/160 (34%), Gaps = 23/160 (14%)

Query: 452 AAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRA 511
           A PP + P  P PAA    G+  A P P  P  GG    S      A AA P P    +A
Sbjct: 288 AGPPTAAPAVPPPAAAQNGGSAGAAPAPA-PAAGGPAGVSGQPGPGAAAAAPAPGV--KA 344

Query: 512 PPPRPAVEQPPPKVYVTRVR-PGQRASPRA---------PAPRAPWPPFPGVFLHPRPLP 561
             P+  V+  PP         P   A+            P+P A  PP PG    P  LP
Sbjct: 345 ESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGT---PTGLP 401

Query: 562 R-------VQLRAPPRPPRPHGRRTGGPQATQPRPPARAQ 594
           +         L   P       R T  P    PR P   Q
Sbjct: 402 KGAAGAVTQSLSRTPTATTSGIRATLTPTVLAPRLPQPPQ 441



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 55/193 (28%), Positives = 66/193 (34%), Gaps = 33/193 (17%)

Query: 457 SGPQSPAPAAPAQ--PGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPP 514
           +G     PAAPA+  PGA   PP   R R GG               RP     G   P 
Sbjct: 68  AGAAGAGPAAPAEGAPGAAPEPPPAGRARPGG-----------GGPQRP-----GPPSPR 111

Query: 515 RPAVEQ-PPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPR 573
           RP V   P P     R  P   A   AP P A       V   P P P     A P  P 
Sbjct: 112 RPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAA-----AAVAAGPEPAPAGP--AKPAGPA 164

Query: 574 PHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTSFL---- 629
               R G      P P       +    G A+TL  +A  ++S+    A P  S +    
Sbjct: 165 ALAARAGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSH--HAAAPAVSLVNNGP 222

Query: 630 -SLSQVSGPQLPG 641
            +L  +  P  PG
Sbjct: 223 AALLPLPKPAAPG 235



 Score = 38.1 bits (87), Expect = 0.043
 Identities = 44/176 (25%), Positives = 55/176 (31%), Gaps = 21/176 (11%)

Query: 513 PPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRV-------QL 565
           P  P V           V  G  A      P AP    PG    P P  R        Q 
Sbjct: 45  PRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQR 104

Query: 566 RAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPV 625
             PP P RP       P A + RPP    A        A  +        +  +  A P 
Sbjct: 105 PGPPSPRRPLVPAGPAPPAAKLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPA 164

Query: 626 TSFLSLSQVSGPQLPGEGEEEEEGEDDGAPGDEAASE---------DSEEAAGPAL 672
               +L+  +GP  PG G     G   G P    A++         +S  AA PA+
Sbjct: 165 ----ALAARAGPG-PGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAV 215


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 64/215 (29%), Positives = 83/215 (38%), Gaps = 41/215 (19%)

Query: 453 APPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARP--LPLFLGR 510
           +PP  GP +        P    APP PP P     P    A   + +A +P   PL L  
Sbjct: 202 SPP--GPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPP 259

Query: 511 APPPRPAVEQPPPKVYVTRVRPGQRASPRAPA-----PRAPWPPF-------PGVFLHPR 558
            PPP P +   PP  Y     PG +A P +PA     P AP PP        P   L   
Sbjct: 260 IPPPLPLL---PPCGY-----PGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAP 311

Query: 559 PLPRVQLRA---PPRPPRPHG----RRTGGPQA--TQPRPPARAQATQGGREGQARTLG- 608
           PLP V   +   PP PP+        +  G QA    P PP      Q  R G+    G 
Sbjct: 312 PLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAPPGSQPFLQKKRHGRPGAGGG 371

Query: 609 -------PAAPTVDSNLSSEARPVTSFLSLSQVSG 636
                  P A +  + LSS+++  T++    Q  G
Sbjct: 372 KLNPPPAPPARSPTTELSSKSQQATAWTPTQQPGG 406



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 44/164 (26%), Positives = 60/164 (36%), Gaps = 46/164 (28%)

Query: 447 LEPTEAAPPRSGPQSPAPAAPAQPGATLAP----PTPPRPRDGGTPRHSRALSWAARAAR 502
           L+   A+P +   + PAP  P  P A+ +P    P PP P    +            +  
Sbjct: 275 LKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPPLPGVNSS------------SET 322

Query: 503 PLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPR 562
           P PL     PP  P+ + PP K        G +A P  PAP             P   P 
Sbjct: 323 PPPL-----PPKSPSFQAPPQKA-------GAQALPAPPAP-------------PGSQPF 357

Query: 563 VQLRAPPRPPRPHGRRTGGPQATQPRPPARAQATQGGREGQART 606
           +Q +   RP        GG     P PPAR+  T+   + Q  T
Sbjct: 358 LQKKRHGRP-----GAGGGKLNPPPAPPARSPTTELSSKSQQAT 396



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 45/145 (31%), Positives = 51/145 (35%), Gaps = 40/145 (27%)

Query: 458 GPQSPAPAAPAQPGATLAPPT--PPRPRDGGTPRHSRALSWAARAARPLPLFLGRAPPPR 515
           GP S AP+ P  P  T++ P   P  PR G T     A                R  PPR
Sbjct: 125 GPGSRAPS-PRLPNKTISGPLIPPASPRLGNTSEAHGA---------------ARTAPPR 168

Query: 516 PAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPG-------VFLHPRPLPRVQLR-- 566
           P V  PPP             +P  P P  P PP P        +   P PL +  L   
Sbjct: 169 PNVPAPPP------------PTPPPPPPPLP-PPLPSSSPIKTPLVSPPGPLTKGNLPVV 215

Query: 567 APPRPPRPHGRRTGGPQATQPRPPA 591
           APP P  P       P    P PPA
Sbjct: 216 APPVPCAPPPPPPPPPPTPPPLPPA 240



 Score = 37.0 bits (84), Expect = 0.097
 Identities = 41/152 (26%), Positives = 53/152 (34%), Gaps = 22/152 (14%)

Query: 483 RDGGTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPA 542
           ++GG   ++R  S          LF G  P  RPA ++      V   + GQ    RAP+
Sbjct: 81  KEGGGSANTRGASTPPTLG---DLFAGGFPVLRPAGQRD-----VAGGKTGQGPGSRAPS 132

Query: 543 PRAPWPPFPGVFLHPRPLPRV---------QLRAPPRPPRPHGRRTGGPQATQPRPPARA 593
           PR P     G  + P   PR+            APPRP  P       P    P PP   
Sbjct: 133 PRLPNKTISGPLIPPAS-PRLGNTSEAHGAARTAPPRPNVP----APPPPTPPPPPPPLP 187

Query: 594 QATQGGREGQARTLGPAAPTVDSNLSSEARPV 625
                    +   + P  P    NL   A PV
Sbjct: 188 PPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPV 219



 Score = 32.3 bits (72), Expect = 2.4
 Identities = 24/83 (28%), Positives = 30/83 (36%), Gaps = 16/83 (19%)

Query: 444 LDSLEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTP-----RHSRALSWAA 498
           L  +  +   PP   P+SP+  AP Q     A P PP P  G  P     RH R  +   
Sbjct: 313 LPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALPAPPAP-PGSQPFLQKKRHGRPGAGGG 371

Query: 499 RAARPLPLFLGRAPPPRPAVEQP 521
           +            PPP P    P
Sbjct: 372 KL----------NPPPAPPARSP 384


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 57.0 bits (136), Expect = 9e-08
 Identities = 70/249 (28%), Positives = 90/249 (36%), Gaps = 45/249 (18%)

Query: 410  KEEGDEDEEDEVQRRAFLFLNPDDFLDDEDEGEL------LDSLE-------PTEAAPPR 456
            +EE +E+EE+ V   +     P+DF  D +E  L      +DSL         TEA  P 
Sbjct: 1142 EEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPE 1201

Query: 457  SGP----QSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPLFLGRAP 512
              P    + P P    +P  +  PP  P     G    S         ARP PL   RAP
Sbjct: 1202 ERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARP-PLSPERAP 1260

Query: 513  PPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPP 572
                 VE  PP +    ++      P  P PR P PP P     P          P  PP
Sbjct: 1261 EHDLEVEPEPPMMLPLPLQ------PPLPPPRPPRPPSP-----PPEPETTDASHPSVPP 1309

Query: 573  RPHGRRTGGPQATQPRPPARAQATQGGREGQARTLGPAAPTVDSNLSSEARPVTSFLSLS 632
             P           +  PP          + Q+    PA P  +  LS      +S LSL 
Sbjct: 1310 EP---------LAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGG----SSGLSL- 1355

Query: 633  QVSGPQLPG 641
              S PQ+PG
Sbjct: 1356 --SSPQVPG 1362



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 52/174 (29%), Positives = 59/174 (33%), Gaps = 33/174 (18%)

Query: 435 LDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATL-----APPTPPRPRDG---- 485
           L D DE E LD L      PP  GP  PA          L       PT  +  +G    
Sbjct: 577 LPDSDEDEELD-LGLGPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPTSEKMDEGQQSS 635

Query: 486 ------GTPRHSRALSWAARAARPLPLFLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPR 539
                        A   +A   +P+ +  G A    P+V  P      T   P     P 
Sbjct: 636 GEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAP------TLPLPPPPGFPP 689

Query: 540 APAPRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRRTGGPQATQPRPPARA 593
            P P  P PP PG F  P PLP      PP PP P       P  T P PP  A
Sbjct: 690 LPPPPPPPPPQPG-FPMPPPLP-----PPPPPPPP-----AHPAVTVPPPPLPA 732



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 36/109 (33%), Positives = 39/109 (35%), Gaps = 37/109 (33%)

Query: 447 LEPTEAAPPRSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHSRALSWAARAARPLPL 506
           L P    PP   P    P  P QPG  + PP PP P                    P P 
Sbjct: 681 LPPPPGFPPLPPP---PPPPPPQPGFPMPPPLPPPP--------------------PPP- 716

Query: 507 FLGRAPPPRPAVEQPPPKVYVTRVRPGQRASPRAPAPRAPWPPF-PGVF 554
                PP  PAV  PPP +      PG    P  P    P PPF PG+F
Sbjct: 717 -----PPAHPAVTVPPPPL---PAPPGVPPPPILP----PLPPFPPGLF 753



 Score = 37.7 bits (86), Expect = 0.057
 Identities = 50/169 (29%), Positives = 60/169 (35%), Gaps = 33/169 (19%)

Query: 456  RSGPQSPAPAAPAQPGATLAPPTPPRPRDGGTPRHS--RALSWAARAARP-LPLFLGRAP 512
            R+  ++P P  P  P A LA   PP  R  G PR S    LS      RP     LGR  
Sbjct: 1448 RAQARAPTPLPPLLP-APLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGREL 1506

Query: 513  PPRPAVEQPP--PKVYVTRVRPGQRASPRAPAPRAPWPPFPGVFLHPRPLPRVQLRAPPR 570
               P   Q P  P  +  R       +   PAP  P PP P                PP 
Sbjct: 1507 LLLPGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQP----------------PPP 1550

Query: 571  PPRPHGRRTGGP----------QATQPRPPARAQATQGGREGQARTLGP 609
            PP P    T  P          +A  P P  R + T+   E  A++ GP
Sbjct: 1551 PPPPPVEPTKLPFKELDNQWPSEAIPPGPRGRDEVTEEYME-LAKSRGP 1598



 Score = 36.2 bits (82), Expect = 0.17
 Identities = 63/244 (25%), Positives = 86/244 (35%), Gaps = 48/244 (19%)

Query: 431  PDDFLDDEDEGELLDSLEPTEAAPPRSGPQSPAPAAPAQPGATLA--PPTPPRPRDGGTP 488
            P+  L+ E E  ++  L      PP   P+ P+P  P +P  T A  P  PP P     P
Sbjct: 1260 PEHDLEVEPEPPMMLPLPLQPPLPPPRPPRPPSP--PPEPETTDASHPSVPPEPLAEDHP 1317

Query: 489  RHSRALSWA---ARAARPLPLFLGRAPP---PRPAVEQPPPKVYVTRVRPGQRASPRAPA 542
             H+  L  +   +++   +P   G  PP       +    P+V      PG   S  AP+
Sbjct: 1318 PHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSSGLSLSSPQV------PGSPFSYPAPS 1371

Query: 543  --------PRAPWPPFPGVFLHPRPLPRVQLRAPPRPPRPHGRR--TGGPQATQ------ 586
                    PR P   F        P   + L   P  P P GRR    GP A+       
Sbjct: 1372 PSLSSGGLPRTPGRDFSFTPTFSEPSGPLLL---PVCPLPTGRRDERSGPLASPVLLETG 1428

Query: 587  -----PRPPARAQATQGGREGQARTLGPAAPTVDSNLSS--------EARPVTSFLSLSQ 633
                 P P     A       QAR   P  P + + L+S          RP  S  S+  
Sbjct: 1429 LPLPLPLPLPLPLALPAVLRAQARAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLS 1488

Query: 634  VSGP 637
            + GP
Sbjct: 1489 LDGP 1492


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.137    0.425 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 50,068,891
Number of Sequences: 37866
Number of extensions: 3161006
Number of successful extensions: 34460
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 235
Number of HSP's successfully gapped in prelim test: 1689
Number of HSP's that attempted gapping in prelim test: 19899
Number of HSP's gapped (non-prelim): 10014
length of query: 1039
length of database: 18,247,518
effective HSP length: 112
effective length of query: 927
effective length of database: 14,006,526
effective search space: 12984049602
effective search space used: 12984049602
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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