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Search of human proteins with 40788015
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40788015 caspase recruitment domain protein 12 [Homo
sapiens]
(1024 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40788015 caspase recruitment domain protein 12 [Homo sapiens] 2038 0.0
gi|119393876 NLR family, apoptosis inhibitory protein isoform 2 ... 209 1e-53
gi|119393878 NLR family, apoptosis inhibitory protein isoform 1 ... 209 1e-53
gi|113205085 leucine rich repeat containing 31 [Homo sapiens] 61 5e-09
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 56 2e-07
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 54 6e-07
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 52 2e-06
gi|5174617 nucleotide-binding oligomerization domain containing ... 52 4e-06
gi|11545912 nucleotide-binding oligomerization domain containing... 51 5e-06
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 49 2e-05
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 49 3e-05
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 7e-05
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 7e-05
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 7e-05
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 7e-05
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 7e-05
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 7e-05
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 7e-05
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 47 7e-05
gi|238908508 leucine-rich repeat and death domain-containing pro... 47 1e-04
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 46 2e-04
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 46 2e-04
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 46 2e-04
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 46 2e-04
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 46 2e-04
gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo sap... 45 3e-04
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 45 3e-04
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 45 3e-04
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 45 3e-04
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 45 3e-04
>gi|40788015 caspase recruitment domain protein 12 [Homo sapiens]
Length = 1024
Score = 2038 bits (5281), Expect = 0.0
Identities = 1024/1024 (100%), Positives = 1024/1024 (100%)
Query: 1 MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILK 60
MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILK
Sbjct: 1 MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILK 60
Query: 61 KGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPL 120
KGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPL
Sbjct: 61 KGSESCNLFLKSLKEWNYPLFQDLNGQSLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYPL 120
Query: 121 GEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQ 180
GEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQ
Sbjct: 121 GEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQ 180
Query: 181 RIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLR 240
RIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLR
Sbjct: 181 RIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLR 240
Query: 241 QRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDM 300
QRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDM
Sbjct: 241 QRVLFLLDGYNEFKPQNCPEIEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDM 300
Query: 301 TEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQT 360
TEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQT
Sbjct: 301 TEDSAQALIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQT 360
Query: 361 TLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDV 420
TLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDV
Sbjct: 361 TLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDV 420
Query: 421 LLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSI 480
LLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSI
Sbjct: 421 LLTTGLLCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSI 480
Query: 481 SDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNT 540
SDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNT
Sbjct: 481 SDITSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNT 540
Query: 541 TEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFE 600
TEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFE
Sbjct: 541 TEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFE 600
Query: 601 HLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFR 660
HLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFR
Sbjct: 601 HLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFR 660
Query: 661 TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVE 720
TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVE
Sbjct: 661 TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVE 720
Query: 721 ASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDA 780
ASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDA
Sbjct: 721 ASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDA 780
Query: 781 IKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKIL 840
IKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKIL
Sbjct: 781 IKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKIL 840
Query: 841 AQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLL 900
AQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLL
Sbjct: 841 AQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLL 900
Query: 901 KHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
KHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV
Sbjct: 901 KHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
Query: 961 FENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFK 1020
FENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFK
Sbjct: 961 FENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFK 1020
Query: 1021 LVTA 1024
LVTA
Sbjct: 1021 LVTA 1024
>gi|119393876 NLR family, apoptosis inhibitory protein isoform 2 [Homo
sapiens]
Length = 1241
Score = 209 bits (532), Expect = 1e-53
Identities = 236/951 (24%), Positives = 416/951 (43%), Gaps = 112/951 (11%)
Query: 150 EQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLS--R 207
E L L + L S +EGE+G GK+ LL++IA LW SG C L +F+ VF+L LS R
Sbjct: 289 EPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTR 348
Query: 208 AQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPE-IEALIK 266
GL +CDQLL+ G++ + ++ +L+ +VLFLLD Y E + P+ I LI+
Sbjct: 349 PDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEIC--SIPQVIGKLIQ 406
Query: 267 ENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAE--GLLLQ 324
+NH + +++ T R IR++ E+ + ++R++ + ++
Sbjct: 407 KNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVY 466
Query: 325 IQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAAS 384
K++ L+ + KTPLFV CA S +F ++ + L +NK A +
Sbjct: 467 FGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNK------ATA 520
Query: 385 DFIRS-LDHCGDLALEGVFSHKFDFELQDVSS--VNEDVLLTTGLLCKYTAQRFKPKYKF 441
+ +++ + CG+LAL+G FS F+F D++ V+ED LT L+ K+TAQR +P Y+F
Sbjct: 521 EILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRF 580
Query: 442 FHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEA 501
+FQE+ AG RL LL S E G +L+++ S S Y++ L Y SS+ +
Sbjct: 581 LSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYV--SSLPS 638
Query: 502 TRA---VMKHLA-AVYQHGCLLGLSIAKRPLWRQ-------ESLQSVKNTTEQEILKAIN 550
T+A ++ HL V L +S L Q + L+ + Q ++
Sbjct: 639 TKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVS 698
Query: 551 INSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFD------------- 597
+ V YQ +T +A S F QG++L + + N+ Y FD
Sbjct: 699 EHLLVLALKTAYQSNT-VAACSPFVLQFLQGRTLTLGALNL-QYFFDHPESLSLLRSIHF 756
Query: 598 -----------FFEHLPNC--ASALDFIKLDFYGG--AMASWEK---AAEDTGGIHMEEA 639
F L C S + I D+ M WE+ ED +M +
Sbjct: 757 PIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYM-DM 815
Query: 640 PETYIPSRAVSLFFNWKQEFR--TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRC 697
P + + ++++ LEV + D + + + L +FS++ + L +
Sbjct: 816 QRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHS 875
Query: 698 AGVAGSLSLVLSTCK-NIYSLMVEASPLTIEDERHITSVTNLKTLSIH---DLQNQRLPG 753
G S+ L K ++ + L+ ++ + ++ +L++L + Q+Q P
Sbjct: 876 RGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPN 935
Query: 754 GLTDSLGNLKNLTKLIMDNIKM----------------------NEEDAIKLAEGLKNLK 791
D LK L+ + NI + E D KL + ++N
Sbjct: 936 --LDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSP 993
Query: 792 KMCLFHL--THLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVK 849
+ +FHL SD G M +V L EI+ AV +A +L N +
Sbjct: 994 NLHVFHLKCNFFSDFGSLMTMLVSCKK-----LTEIKFSDSFF--QAVPFVA-SLPNFIS 1045
Query: 850 LSILDL-SENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQ 908
L IL+L + + +++ +E ++ ++ LE+ L+LP G + +++ +++
Sbjct: 1046 LKILNLEGQQFPDEETSEKFAYILGSLSNLEE---LILPTGDGIYRVAKLIIQQCQQLHC 1102
Query: 909 LVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGN-RVSSDGWLAFMGVFENLKQL 967
L L L D + + + + L L+ N +++ +G+ F +N+ L
Sbjct: 1103 LRVLSFFK-TLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNL 1161
Query: 968 VFFDFS---TKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVI 1015
D S T+ V+ LSQ + +L L ++ W D DD++++
Sbjct: 1162 QELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALL 1212
Score = 40.0 bits (92), Expect = 0.011
Identities = 54/248 (21%), Positives = 105/248 (42%), Gaps = 42/248 (16%)
Query: 702 GSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDS--- 758
GSL +L +CK + ++ S + + S+ N +L I +L+ Q+ P T
Sbjct: 1009 GSLMTMLVSCKKLTE--IKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFA 1066
Query: 759 --LGNLKNLTKLIM---DNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVK 813
LG+L NL +LI+ D I + I+ + L L+ + F + + E I K
Sbjct: 1067 YILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVE----IAK 1122
Query: 814 -SLSSEPCDLEEIQL-VSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHEL 871
++S LE ++L ++ ++ + Q L N+ L LD+S ++ E +A
Sbjct: 1123 VAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQAT--- 1179
Query: 872 IDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFF 931
++ SL + + +P+L++L + +W L +I +L
Sbjct: 1180 -----------------------TVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMK 1216
Query: 932 GKNPLKNF 939
++P +
Sbjct: 1217 ERHPQSKY 1224
>gi|119393878 NLR family, apoptosis inhibitory protein isoform 1 [Homo
sapiens]
Length = 1403
Score = 209 bits (532), Expect = 1e-53
Identities = 236/951 (24%), Positives = 416/951 (43%), Gaps = 112/951 (11%)
Query: 150 EQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLS--R 207
E L L + L S +EGE+G GK+ LL++IA LW SG C L +F+ VF+L LS R
Sbjct: 451 EPLVLPEVFGNLNSVMCVEGEAGSGKTVLLKKIAFLWASGCCPLLNRFQLVFYLSLSSTR 510
Query: 208 AQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPE-IEALIK 266
GL +CDQLL+ G++ + ++ +L+ +VLFLLD Y E + P+ I LI+
Sbjct: 511 PDEGLASIICDQLLEKEGSVTEMCVRNIIQQLKNQVLFLLDDYKEIC--SIPQVIGKLIQ 568
Query: 267 ENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKELAE--GLLLQ 324
+NH + +++ T R IR++ E+ + ++R++ + ++
Sbjct: 569 KNHLSRTCLLIAVRTNRARDIRRYLETILEIKAFPFYNTVCILRKLFSHNMTRLRKFMVY 628
Query: 325 IQKSRCLRNLMKTPLFVVITCAIQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGVAAS 384
K++ L+ + KTPLFV CA S +F ++ + L +NK A +
Sbjct: 629 FGKNQSLQKIQKTPLFVAAICAHWFQYPFDPSFDDVAVFKSYMERLSLRNK------ATA 682
Query: 385 DFIRS-LDHCGDLALEGVFSHKFDFELQDVSS--VNEDVLLTTGLLCKYTAQRFKPKYKF 441
+ +++ + CG+LAL+G FS F+F D++ V+ED LT L+ K+TAQR +P Y+F
Sbjct: 683 EILKATVSSCGELALKGFFSCCFEFNDDDLAEAGVDEDEDLTMCLMSKFTAQRLRPFYRF 742
Query: 442 FHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYTCGSSVEA 501
+FQE+ AG RL LL S E G +L+++ S S Y++ L Y SS+ +
Sbjct: 743 LSPAFQEFLAGMRLIELLDSDRQEHQDLGLYHLKQINSPMMTVSAYNNFLNYV--SSLPS 800
Query: 502 TRA---VMKHLA-AVYQHGCLLGLSIAKRPLWRQ-------ESLQSVKNTTEQEILKAIN 550
T+A ++ HL V L +S L Q + L+ + Q ++
Sbjct: 801 TKAGPKIVSHLLHLVDNKESLENISENDDYLKHQPEISLQMQLLRGLWQICPQAYFSMVS 860
Query: 551 INSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFD------------- 597
+ V YQ +T +A S F QG++L + + N+ Y FD
Sbjct: 861 EHLLVLALKTAYQSNT-VAACSPFVLQFLQGRTLTLGALNL-QYFFDHPESLSLLRSIHF 918
Query: 598 -----------FFEHLPNC--ASALDFIKLDFYGG--AMASWEK---AAEDTGGIHMEEA 639
F L C S + I D+ M WE+ ED +M +
Sbjct: 919 PIRGNKTSPRAHFSVLETCFDKSQVPTIDQDYASAFEPMNEWERNLAEKEDNVKSYM-DM 977
Query: 640 PETYIPSRAVSLFFNWKQEFR--TLEVTLRDFSKLNKQDIRYLGKIFSSATSLRLQIKRC 697
P + + ++++ LEV + D + + + L +FS++ + L +
Sbjct: 978 QRRASPDLSTGYWKLSPKQYKIPCLEVDVNDIDVVGQDMLEILMTVFSASQRIELHLNHS 1037
Query: 698 AGVAGSLSLVLSTCK-NIYSLMVEASPLTIEDERHITSVTNLKTLSIH---DLQNQRLPG 753
G S+ L K ++ + L+ ++ + ++ +L++L + Q+Q P
Sbjct: 1038 RGFIESIRPALELSKASVTKCSISKLELSAAEQELLLTLPSLESLEVSGTIQSQDQIFPN 1097
Query: 754 GLTDSLGNLKNLTKLIMDNIKM----------------------NEEDAIKLAEGLKNLK 791
D LK L+ + NI + E D KL + ++N
Sbjct: 1098 --LDKFLCLKELSVDLEGNINVFSVIPEEFPNFHHMEKLLIQISAEYDPSKLVKLIQNSP 1155
Query: 792 KMCLFHL--THLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVK 849
+ +FHL SD G M +V L EI+ AV +A +L N +
Sbjct: 1156 NLHVFHLKCNFFSDFGSLMTMLVSCKK-----LTEIKFSDSFF--QAVPFVA-SLPNFIS 1207
Query: 850 LSILDL-SENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQ 908
L IL+L + + +++ +E ++ ++ LE+ L+LP G + +++ +++
Sbjct: 1208 LKILNLEGQQFPDEETSEKFAYILGSLSNLEE---LILPTGDGIYRVAKLIIQQCQQLHC 1264
Query: 909 LVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGN-RVSSDGWLAFMGVFENLKQL 967
L L L D + + + + L L+ N +++ +G+ F +N+ L
Sbjct: 1265 LRVLSFFK-TLNDDSVVEIAKVAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNL 1323
Query: 968 VFFDFS---TKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVI 1015
D S T+ V+ LSQ + +L L ++ W D DD++++
Sbjct: 1324 QELDISRHFTECIKAQATTVKSLSQCVLRLPRLIRLNMLSWLLDADDIALL 1374
Score = 40.0 bits (92), Expect = 0.011
Identities = 54/248 (21%), Positives = 105/248 (42%), Gaps = 42/248 (16%)
Query: 702 GSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDS--- 758
GSL +L +CK + ++ S + + S+ N +L I +L+ Q+ P T
Sbjct: 1171 GSLMTMLVSCKKLTE--IKFSDSFFQAVPFVASLPNFISLKILNLEGQQFPDEETSEKFA 1228
Query: 759 --LGNLKNLTKLIM---DNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVK 813
LG+L NL +LI+ D I + I+ + L L+ + F + + E I K
Sbjct: 1229 YILGSLSNLEELILPTGDGIYRVAKLIIQQCQQLHCLRVLSFFKTLNDDSVVE----IAK 1284
Query: 814 -SLSSEPCDLEEIQL-VSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHEL 871
++S LE ++L ++ ++ + Q L N+ L LD+S ++ E +A
Sbjct: 1285 VAISGGFQKLENLKLSINHKITEEGYRNFFQALDNMPNLQELDISRHFTECIKAQAT--- 1341
Query: 872 IDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFF 931
++ SL + + +P+L++L + +W L +I +L
Sbjct: 1342 -----------------------TVKSLSQCVLRLPRLIRLNMLSWLLDADDIALLNVMK 1378
Query: 932 GKNPLKNF 939
++P +
Sbjct: 1379 ERHPQSKY 1386
>gi|113205085 leucine rich repeat containing 31 [Homo sapiens]
Length = 552
Score = 61.2 bits (147), Expect = 5e-09
Identities = 90/375 (24%), Positives = 149/375 (39%), Gaps = 44/375 (11%)
Query: 671 KLNKQDIRYLGKIFSSATSLR-LQIKRCAGVAGSLSLVLSTCKN---IYSLMVEASPLTI 726
+L D++ LG+ F L L + + V G+L L+L + I + + LT
Sbjct: 153 RLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTS 212
Query: 727 EDERHITSVTN-LKTLSIHDLQ-NQRLPGGLTDSLGNLK---NLTKLIMDNIKMNEEDAI 781
ED + + L++L + DL N+ + G L LK NL L + + ++++
Sbjct: 213 EDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVK 272
Query: 782 KLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILA 841
L + L ++ L+ D+G G + L L+ + L C L+A+ V L
Sbjct: 273 ILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLK-HLQVLDLHQCSLTADDVMSLT 331
Query: 842 QNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALM---------------- 885
Q + L L LDLS N K + L+ R+ L L +L+
Sbjct: 332 QVIPLLSNLQELDLSAN---KKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAE 388
Query: 886 ------------LPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGK 933
L W V G+L LL+ L+ L L L + L ++ +L +
Sbjct: 389 ASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQT 448
Query: 934 NPLKNFQQLNLAGN-RVSSDGWLAFMGVFENLKQLVFFDFSTK--EFLPDPALVRKLSQV 990
L Q+L+L+ N + GW F LK+L+ D S + F R L
Sbjct: 449 GHLAKLQKLDLSYNDSICDAGWTMFCQNVRFLKELIELDISLRPSNFRDCGQWFRHLLYA 508
Query: 991 LSKLTFLQEARLVGW 1005
++KL + E + W
Sbjct: 509 VTKLPQITEIGMKRW 523
Score = 51.2 bits (121), Expect = 5e-06
Identities = 65/262 (24%), Positives = 113/262 (43%), Gaps = 13/262 (4%)
Query: 678 RYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTN 737
RYLG++ S K G L K++ L + LT +D +T V
Sbjct: 279 RYLGELRKLDLSCN---KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIP 335
Query: 738 L-KTLSIHDLQNQRLPGGLTDSLGN----LKNLTKLIMDNIKMNEEDAIKLAEGLKNLKK 792
L L DL + G +++L + L L L+++N + E LAE +L
Sbjct: 336 LLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSA 395
Query: 793 MCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLH--NLVKL 850
+ +F+L+ +G + ++++L L+ ++L SC L V +LA + +L KL
Sbjct: 396 LEVFNLSWNKCVGGNLKLLLETLKLS-MSLQVLRLSSCSLVTEDVALLASVIQTGHLAKL 454
Query: 851 SILDLSENYLEKDGNEALH-ELIDRMNVLEQLTALMLPWGCDVQGS-LSSLLKHLEEVPQ 908
LDLS N D + + + + L +L + P G LL + ++PQ
Sbjct: 455 QKLDLSYNDSICDAGWTMFCQNVRFLKELIELDISLRPSNFRDCGQWFRHLLYAVTKLPQ 514
Query: 909 LVKLGLKNWRLTDTEIRILGAF 930
+ ++G+K W L ++ L F
Sbjct: 515 ITEIGMKRWILPASQEEELECF 536
Score = 39.7 bits (91), Expect = 0.015
Identities = 31/113 (27%), Positives = 55/113 (48%), Gaps = 18/113 (15%)
Query: 851 SILDLSENYLEKDGNEALHELIDRMNV----------------LEQLTALMLPWGCDVQG 894
S ++ +E++L+K G +A+++ +D N L L L + W V G
Sbjct: 70 SSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGG 129
Query: 895 SLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGN 947
+L S+ + + V +L L L + RLT +++ LG F P ++LNL+ N
Sbjct: 130 TLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIP--ELEELNLSWN 180
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 55.8 bits (133), Expect = 2e-07
Identities = 190/859 (22%), Positives = 325/859 (37%), Gaps = 163/859 (18%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFL---RLSRAQGGLFETLCDQLLD 222
++ G +G GK+TL Q++ + W + KFK+ F+L LSR F L D
Sbjct: 210 VLYGPAGLGKTTLAQKLMLDWAED--NLIHKFKYAFYLSCRELSRLGPCSFAELV--FRD 265
Query: 223 IPGTIRKQTFMAMLLKLRQRVLFLLDGYNEF----------------KPQNCPE-IEALI 265
P Q + +L +++LF++DG++E K + P + +L+
Sbjct: 266 WP---ELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLL 322
Query: 266 KENHRFKNMVIVTTTTECLRHIRQFGALTAEV---GDMTEDSAQALIREVLIKELAEGLL 322
K ++VTT LR +R + G + ED +R ++ A
Sbjct: 323 NRVMLPKAALLVTTRPRALRDLRILAEEPIYIRVEGFLEEDRRAYFLRHFGDEDQAMRAF 382
Query: 323 LQIQKSRCLRNLMKTPLFVVITCA---IQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHK 379
++ + L L P I C +QM + E T T F L + +
Sbjct: 383 ELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP---Q 439
Query: 380 GVAASDFIRSLDHCGDLALEGVFS-----HKFDFELQDVSSVNEDVLLTTGLLCKYTAQR 434
G +R+L LA +G+++ H+ D E V + + L +L +
Sbjct: 440 GAQLRGALRTLSL---LAAQGLWAQTSVLHREDLERLGVQESDLRLFLDGDILRQDRVS- 495
Query: 435 FKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYT 494
K Y F H SFQ++ L++L + E EE +G+ I D+ S + R
Sbjct: 496 -KGCYSFIHLSFQQF-----LTALFYTLEKEEEEDRDGHTW---DIGDVQKLLSGVERLR 546
Query: 495 CGSSVE--------ATRAVMKHLAAVYQHGCLLGLSIAKRPLWR---------------Q 531
++ A K L A + GC + I K+ L R Q
Sbjct: 547 NPDLIQAGYYSFGLANEKRAKELEATF--GCRMSPDI-KQELLRCDISCKGGHSTVTDLQ 603
Query: 532 ESLQSVKNTTEQEILKAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNI 591
E L + + E+E++K + + F E +HL S+ + Q SL + N+
Sbjct: 604 ELLGCLYESQEEELVKEV-MAQFKEISLHLNAVDVVPSSFCVKHCRNLQKMSLQVIKENL 662
Query: 592 PDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEE------------- 638
P+ + S D L F+ + S + +D G+ + +
Sbjct: 663 PENVTASESDAEVERSQDDQHMLPFWTD-LCSIFGSNKDLMGLAINDSFLSASLVRILCE 721
Query: 639 --APETYIPSRAVSLFFNWKQEFRTLEVTLRDFSKL-------NKQD------------- 676
A +T R V + R L + LR + N QD
Sbjct: 722 QIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYLTLQGNDQDDMFPALCEVLRHP 781
Query: 677 ---IRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLS-TCKNI--YSLMVEASPLTIEDER 730
+RYLG + SAT+ ++ A ++ +L + S TC N+ L+ E + L R
Sbjct: 782 ECNLRYLGLVSCSATT-----QQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLR 836
Query: 731 HITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNL 790
H L+ LS+ + LT++ N K+L +++ + + L
Sbjct: 837 HPKCF--LQRLSLENCH-------LTEA--NCKDLAAVLVVS---------------REL 870
Query: 791 KKMCLFHLTHLSDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVK 849
+CL + IG G+ ++ + L C L+ + L +C ++++ L + L
Sbjct: 871 THLCLAK----NPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSS 926
Query: 850 LSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQ 908
L LDL N++ G + L E + + L L L L WGC + S L L
Sbjct: 927 LLCLDLGLNHIGVKGMKFLCEALRK--PLCNLRCLWL-WGCSIPPFSCEDLCSALSCNQS 983
Query: 909 LVKLGLKNWRLTDTEIRIL 927
LV L L L + +++L
Sbjct: 984 LVTLDLGQNPLGSSGVKML 1002
Score = 35.0 bits (79), Expect = 0.36
Identities = 37/148 (25%), Positives = 65/148 (43%), Gaps = 6/148 (4%)
Query: 765 LTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIG-EGMDYIVKSLSSEPCDLE 823
L L++ N + + L + L+ + L L+ IG +GM ++ ++L C+L
Sbjct: 899 LQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLG-LNHIGVKGMKFLCEALRKPLCNLR 957
Query: 824 EIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTA 883
+ L C + + + L L L LDL +N L G + L E + + +
Sbjct: 958 CLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLR 1017
Query: 884 LMLPWGCDVQGSLSSLLKHLEEV-PQLV 910
L + D L+ LL+ +EE PQL+
Sbjct: 1018 LKID---DFNDELNKLLEEIEEKNPQLI 1042
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 54.3 bits (129), Expect = 6e-07
Identities = 93/399 (23%), Positives = 170/399 (42%), Gaps = 54/399 (13%)
Query: 88 SLFHQTSEGDLDDLAQDLKDLYHTPSFLNFYP--LGEDIDIIFNLKSTFTEPVLWRKDQH 145
+LF Q + DL AQ+ + LN Y + E +I+ ++ P + K+
Sbjct: 74 NLFLQINRKDLWTKAQE-----EMRNKLNPYRKHMKETFQLIWEKETCLHVPEHFYKETM 128
Query: 146 HHRVEQLTLNGLLQALQSPCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRL 205
+ ++L A + ++EG G GK+TLL+++ + W G +F FVFFL +
Sbjct: 129 KNEYKELNDAYTAAARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWK-DRFTFVFFLNV 187
Query: 206 SRAQGGLFETLCDQLL--DIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQNCPEIEA 263
G+ ET +LL D P + K + + +R+LF++DG+ + K +++A
Sbjct: 188 CE-MNGIAETSLLELLSRDWPESSEK---IEDIFSQPERILFIMDGFEQLKFN--LQLKA 241
Query: 264 LIKENHRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIRE-VLIKELAEG-- 320
+ ++ R + + + ++ + + +L +G + ++R LIK L
Sbjct: 242 DLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLLGFSES 301
Query: 321 ------LLLQIQKSRCLR--NLMKT--PLFV----------VITCA---IQMGES-EFHS 356
+KS+ L+ N ++ PLF+ V TC ++ GE E +S
Sbjct: 302 EKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGEDLEINS 361
Query: 357 HTQTTLFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVS-- 414
T L+ +F + + ++SL C LA EG++++ F F D+
Sbjct: 362 QNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSL--CA-LAAEGIWTYTFVFSHGDLRRN 418
Query: 415 --SVNEDVLLTTGLLCKYTAQRFKPKYKFFHKSFQEYTA 451
S +E V+ L QR + F H QE+ A
Sbjct: 419 GLSESEGVMWVGMRL----LQRRGDCFAFMHLCIQEFCA 453
Score = 43.5 bits (101), Expect = 0.001
Identities = 27/80 (33%), Positives = 42/80 (52%), Gaps = 5/80 (6%)
Query: 794 CLFHLTHLSDI-----GEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLV 848
C L HLS + EGM + ++L C LE + L+ CCL++ + +++ L
Sbjct: 740 CNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSK 799
Query: 849 KLSILDLSENYLEKDGNEAL 868
LS+LDL N LE +G +L
Sbjct: 800 SLSLLDLGSNALEDNGVASL 819
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 52.4 bits (124), Expect = 2e-06
Identities = 69/254 (27%), Positives = 107/254 (42%), Gaps = 38/254 (14%)
Query: 708 LSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTK 767
+S CK + +PLT E + NL LS++D+ Q LP +++GNL NL
Sbjct: 101 ISFCKALQVADFSGNPLTRLPES-FPELQNLTCLSVNDISLQSLP----ENIGNLYNLAS 155
Query: 768 LIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQL 827
L ++ E L + L L+++ D+G Y + L+++ L
Sbjct: 156 L-----ELRENLLTYLPDSLTQLRRL------EELDLGNNEIYNLPESIGALLHLKDLWL 204
Query: 828 VSCCLSANAVKILAQNLHNLVKLSILDLSENYLEK-----DGNEALHELIDRMNVLEQLT 882
N + L Q + NL L LD+SEN LE+ G +L +L+ N+LE
Sbjct: 205 -----DGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLE--- 256
Query: 883 ALMLPWGCDVQGSLSSL---LKHLEEVPQLVK--LGLKNWRLTDTEIRILGAFFGKNPLK 937
+P G LS L L ++P+ V L LT+ ++ L GK LK
Sbjct: 257 --TIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGK--LK 312
Query: 938 NFQQLNLAGNRVSS 951
LN N++ S
Sbjct: 313 KLSNLNADRNKLVS 326
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 51.6 bits (122), Expect = 4e-06
Identities = 67/278 (24%), Positives = 108/278 (38%), Gaps = 35/278 (12%)
Query: 1 MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILK 60
+ +K N L+ + T + + D+L + + E+ I+C + D R I+ ++
Sbjct: 20 IQLLKSNRELLVTHIRNT--QCLVDNLLKNDYFSAEDAEIVCACPTQPDKVRKILDLVQS 77
Query: 61 KGSESCNLFLKSLKEWNYPLFQDLN--------GQSLFHQTSEG-DLDDLAQDLKDLYH- 110
KG E FL L++ + DL SL Q+ + D +++ + L H
Sbjct: 78 KGEEVSEFFLYLLQQLA-DAYVDLRPWLLEIGFSPSLLTQSKVVVNTDPVSRYTQQLRHH 136
Query: 111 ---TPSFLNFYPLGEDIDIIFNLKSTFTEPVLWRKDQHHHRVEQLTL----NGLLQALQS 163
F+ Y E++ + T E V + + L G+L
Sbjct: 137 LGRDSKFVLCYAQKEELLLEEIYMDTIMELVGFSNESLGSLNSLACLLDHTTGILNEQGE 196
Query: 164 PCIIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRA---------QGGLFE 214
I G++G GKS LLQR+ LW +G+ A KF F F R+ Q LF+
Sbjct: 197 TIFILGDAGVGKSMLLQRLQSLWATGRLDAGVKFFFHFRCRMFSCFKESDRLCLQDLLFK 256
Query: 215 TLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNE 252
C D + A LL+ LF DG +E
Sbjct: 257 HYCYPERD------PEEVFAFLLRFPHVALFTFDGLDE 288
Score = 36.6 bits (83), Expect = 0.12
Identities = 34/129 (26%), Positives = 51/129 (39%), Gaps = 8/129 (6%)
Query: 825 IQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTAL 884
++L C + L+ LH+ K LDL N L G L R LT L
Sbjct: 680 LKLTYCNACSADCSALSFVLHHFPKRLALDLDNNNLNDYGVRELQPCFSR------LTVL 733
Query: 885 MLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNL 944
L G + L + L + + LGL N ++TD R + + K L L
Sbjct: 734 RLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKIL--DECKGLTHLKL 791
Query: 945 AGNRVSSDG 953
N+++S+G
Sbjct: 792 GKNKITSEG 800
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 51.2 bits (121), Expect = 5e-06
Identities = 91/421 (21%), Positives = 172/421 (40%), Gaps = 64/421 (15%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGG-------LFETLCD 218
++ GE+G GKSTLLQR+ +LW +G+ F F F R + LFE C
Sbjct: 296 LVVGEAGSGKSTLLQRLHLLWAAGQDFQEFLFVFPFSCRQLQCMAKPLSVRTLLFEHCCW 355
Query: 219 QLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-----------PQNCPEIEAL--- 264
+ ++ +LL RVL DG++EFK P + ++ L
Sbjct: 356 P------DVGQEDIFQLLLDHPDRVLLTFDGFDEFKFRFTDRERHCSPTDPTSVQTLLFN 409
Query: 265 IKENHRFKN--MVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKE-LAEGL 321
+ + + KN V+ + +R++ + +E + +R+ + +A+ L
Sbjct: 410 LLQGNLLKNARKVVTSRPAAVSAFLRKYIRTEFNLKGFSEQGIELYLRKRHHEPGVADRL 469
Query: 322 LLQIQKSRCLRNLMKTPLF--VVITCAIQMGESEFHSHTQTTLFHTFYDLLIQ------- 372
+ +Q++ L L P+F +V C ++ E S TT Y L++Q
Sbjct: 470 IRLLQETSALHGLCHLPVFSWMVSKCHQELLLQEGGSPKTTT---DMYLLILQHFLLHAT 526
Query: 373 KNKHKHKGVAAS---DFIRSLDHCGDLALEGVFSHKFDFELQDVSSVN---EDVLLTTGL 426
+G+ S + +L H G LAL G+ + F Q + + +D+ L +
Sbjct: 527 PPDSASQGLGPSLLRGRLPTLLHLGRLALWGLGMCCYVFSAQQLQAAQVSPDDISLGFLV 586
Query: 427 LCKYTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTK--------GNGYLQKMV 478
K +F H +FQ + A L+ L++ P + + GN + +++
Sbjct: 587 RAKGVVPGSTAPLEFLHITFQCFFAAFYLA--LSADVPPALLRHLFNCGRPGNSPMARLL 644
Query: 479 SISDI------TSTYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQE 532
I S+ ++LL+ +++ T A + L + G L +++ L R++
Sbjct: 645 PTMCIQASEGKDSSVAALLQKAEPHNLQITAAFLAGLLSREHWGLLAECQTSEKALLRRQ 704
Query: 533 S 533
+
Sbjct: 705 A 705
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 49.3 bits (116), Expect = 2e-05
Identities = 72/331 (21%), Positives = 132/331 (39%), Gaps = 35/331 (10%)
Query: 149 VEQLTLNGLLQALQSPC------IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFF 202
+E +T+ L + + P +++G +G GK+TL +++ + W +G +F +VF+
Sbjct: 147 LESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDWATGTLYP-GRFDYVFY 205
Query: 203 LRLSRAQGGLFETLCDQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEF--------- 253
+ L E+ +QLL Q + +L+ +R+LF+LDG++E
Sbjct: 206 VSCKEVV-LLLESKLEQLL-FWCCGDNQAPVTEILRQPERLLFILDGFDELQRPFEEKLK 263
Query: 254 KPQNCPE---IEALIKENHRFKNMVIVTTTTECLRHIRQFGALTAEV---GDMTEDSAQA 307
K P+ + LI+ + +++TT LR++ V G E+ A+
Sbjct: 264 KRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEPLLKQARHVHILGFSEEERARY 323
Query: 308 LIREVLIKELAEGLLLQIQKSRCLRNLMKTPLFVVITCAIQMGESEFHS------HTQTT 361
++ A+ +QK+ L + P + C+ G+ E T
Sbjct: 324 FSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCSWLQGQMERGKVVLETPRNSTD 383
Query: 362 LFHTFYDLLIQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDVL 421
+F + + + G + R L LA EG+ +F FE ++ N D
Sbjct: 384 IFMAYVSTFLPPD--DDGGCSELSRHRVLRSLCSLAAEGIQHQRFLFEEAELRKHNLDGP 441
Query: 422 LTTGLLCKYTAQ---RFKPKYKFFHKSFQEY 449
L Q K Y F H SFQ++
Sbjct: 442 RLAAFLSSNDYQLGLAIKKFYSFRHISFQDF 472
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 48.5 bits (114), Expect = 3e-05
Identities = 101/477 (21%), Positives = 167/477 (35%), Gaps = 89/477 (18%)
Query: 612 IKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNWKQEFRTLEVTLRDFSK 671
+ L F+G + + EDT +H + +P R + W +E E F
Sbjct: 584 VVLFFFGLLNKNIARELEDT--LHCKISP------RVMEELLKWGEELGKAESASLQFHI 635
Query: 672 LN-------KQDIRYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPL 724
L Q+ + K+ + L I + S S L CK + L + S
Sbjct: 636 LRLFHCLHESQEEDFTKKMLGRIFEVDLNILEDEELQAS-SFCLKHCKRLNKLRLSVSSH 694
Query: 725 TIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLA 784
+E + I + + + +L +NL +L + N K++ L
Sbjct: 695 ILERDLEILETSKFDS-------RMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLC 747
Query: 785 EGLKN------------------LKKMCLF-----HLTHLS----DIGEGMDYIVKSLSS 817
LKN L+ + + LTHL+ +G + I+K+L
Sbjct: 748 LALKNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMTVPLILKALRH 807
Query: 818 EPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMN- 876
C+L+ + L C LSA + + LA L ++ ++ L L N L+ DG + L +
Sbjct: 808 SACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKC 867
Query: 877 VLEQLTALMLPWGCDVQGSLSSLLKHLEEV----PQLVKLGLKNWRLTDTEIRILGAFFG 932
LE+L W C + + KHL + L L L L D ++ L G
Sbjct: 868 ALERLEL----WFCQL---AAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALG 920
Query: 933 KNPLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPD------------ 980
+ P N Q LNL+G + +G + + D + D
Sbjct: 921 R-PDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPH 979
Query: 981 --------------PALVRKLSQVLSKLTFLQEARLVGWQFDDDDLSVITGAFKLVT 1023
A + L VLS L L+G + D D + ++ A K T
Sbjct: 980 RALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKST 1036
Score = 40.4 bits (93), Expect = 0.009
Identities = 81/373 (21%), Positives = 144/373 (38%), Gaps = 61/373 (16%)
Query: 129 NLKSTFTEP---VLWRKDQ---------HHHRVEQLTLNGLLQALQSPCIIEGESGKGKS 176
N+K+ E + W KD H +++L +A ++ G +G GK+
Sbjct: 183 NMKAELLETWDNISWPKDHVYIRNTSKDEHEELQRLLDPNRTRAQAQTIVLVGRAGVGKT 242
Query: 177 TLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQL-LDIPGTIRK-QTFMA 234
TL + + W +G +F +VF+L + + T + + LD P + FM+
Sbjct: 243 TLAMQAMLHWANGVLFQ-QRFSYVFYLSCHKIRYMKETTFAELISLDWPDFDAPIEEFMS 301
Query: 235 MLLKLRQRVLFLLDGYNEF-------------KP-----QNCPE---IEALIKENHRFKN 273
KL LF++DG+ E P Q P + +L+K+
Sbjct: 302 QPEKL----LFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSLLKKELVPLA 357
Query: 274 MVIVTTTTECLRHIRQ------FGALTAEVGDMTEDSAQALIREVLIKELAEGLLLQIQK 327
+++T T +R ++ F +T GD D +R E +L Q++K
Sbjct: 358 TLLITIKTWFVRDLKASLVNPCFVQITGFTGD---DLRVYFMRHFDDSSEVEKILQQLRK 414
Query: 328 SRCLRNLMKTPLFVVITCA------IQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHKGV 381
+ L + P+ C+ ++ + + + T T+L+ F+ L +
Sbjct: 415 NETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAEVDLADD 474
Query: 382 AASDFIRSLDHCGDLALEGVFSHKFDFELQDVSSVNEDVLLTTGLLCKYTAQRFKP---K 438
+ R+L C LA+EG++S F F +D +V L Q+
Sbjct: 475 SWPGQWRAL--CS-LAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDCGGC 531
Query: 439 YKFFHKSFQEYTA 451
F H SFQE+ A
Sbjct: 532 TTFTHLSFQEFFA 544
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+++G+ G+ +++ L + C ++++ L +CCL+ +L+ L L L L LS+N L
Sbjct: 66 NELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLL 125
Query: 861 EKDGNEALHE-LIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRL 919
G + L E L+D LE+ L L + S L L P +L + N +
Sbjct: 126 GDAGLQLLCEGLLDPQCRLEK---LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Query: 920 TDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
+ +R+L +P + + L L V+SD G+
Sbjct: 183 NEAGVRVLCQGLKDSPCQ-LEALKLESCGVTSDNCRDLCGI 222
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+DI E G+ + + L PC LE ++L SC ++++ + L + + L L L N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 861 EKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQLVKLGLKNWRL 919
G+ + EL + + W C + L + L L +L L L
Sbjct: 240 ---GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL 296
Query: 920 TDTEIRIL 927
D R+L
Sbjct: 297 GDEGARLL 304
Score = 30.8 bits (68), Expect = 6.8
Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 779 DAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSA---- 834
D ++ ++LK++ L L D EG + ++L C LE + + SC +A
Sbjct: 275 DLCRVLRAKESLKELSLAG-NELGD--EGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 835 NAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDV-Q 893
+ +LAQN L L +S N LE G + EL + + ++ CDV
Sbjct: 332 HFSSVLAQNRF----LLELQISNNRLEDAG---VRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 894 GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEI 924
S SSL L L +L L N L D I
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGI 415
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+++G+ G+ +++ L + C ++++ L +CCL+ +L+ L L L L LS+N L
Sbjct: 66 NELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLL 125
Query: 861 EKDGNEALHE-LIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRL 919
G + L E L+D LE+ L L + S L L P +L + N +
Sbjct: 126 GDAGLQLLCEGLLDPQCRLEK---LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Query: 920 TDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
+ +R+L +P + + L L V+SD G+
Sbjct: 183 NEAGVRVLCQGLKDSPCQ-LEALKLESCGVTSDNCRDLCGI 222
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+DI E G+ + + L PC LE ++L SC ++++ + L + + L L L N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 861 EKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQLVKLGLKNWRL 919
G+ + EL + + W C + L + L L +L L L
Sbjct: 240 ---GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL 296
Query: 920 TDTEIRIL 927
D R+L
Sbjct: 297 GDEGARLL 304
Score = 30.8 bits (68), Expect = 6.8
Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 779 DAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSA---- 834
D ++ ++LK++ L L D EG + ++L C LE + + SC +A
Sbjct: 275 DLCRVLRAKESLKELSLAG-NELGD--EGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 835 NAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDV-Q 893
+ +LAQN L L +S N LE G + EL + + ++ CDV
Sbjct: 332 HFSSVLAQNRF----LLELQISNNRLEDAG---VRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 894 GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEI 924
S SSL L L +L L N L D I
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGI 415
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+++G+ G+ +++ L + C ++++ L +CCL+ +L+ L L L L LS+N L
Sbjct: 66 NELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLL 125
Query: 861 EKDGNEALHE-LIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRL 919
G + L E L+D LE+ L L + S L L P +L + N +
Sbjct: 126 GDAGLQLLCEGLLDPQCRLEK---LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Query: 920 TDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
+ +R+L +P + + L L V+SD G+
Sbjct: 183 NEAGVRVLCQGLKDSPCQ-LEALKLESCGVTSDNCRDLCGI 222
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+DI E G+ + + L PC LE ++L SC ++++ + L + + L L L N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 861 EKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQLVKLGLKNWRL 919
G+ + EL + + W C + L + L L +L L L
Sbjct: 240 ---GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL 296
Query: 920 TDTEIRIL 927
D R+L
Sbjct: 297 GDEGARLL 304
Score = 30.8 bits (68), Expect = 6.8
Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 779 DAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSA---- 834
D ++ ++LK++ L L D EG + ++L C LE + + SC +A
Sbjct: 275 DLCRVLRAKESLKELSLAG-NELGD--EGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 835 NAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDV-Q 893
+ +LAQN L L +S N LE G + EL + + ++ CDV
Sbjct: 332 HFSSVLAQNRF----LLELQISNNRLEDAG---VRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 894 GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEI 924
S SSL L L +L L N L D I
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGI 415
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+++G+ G+ +++ L + C ++++ L +CCL+ +L+ L L L L LS+N L
Sbjct: 66 NELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLL 125
Query: 861 EKDGNEALHE-LIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRL 919
G + L E L+D LE+ L L + S L L P +L + N +
Sbjct: 126 GDAGLQLLCEGLLDPQCRLEK---LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Query: 920 TDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
+ +R+L +P + + L L V+SD G+
Sbjct: 183 NEAGVRVLCQGLKDSPCQ-LEALKLESCGVTSDNCRDLCGI 222
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+DI E G+ + + L PC LE ++L SC ++++ + L + + L L L N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 861 EKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQLVKLGLKNWRL 919
G+ + EL + + W C + L + L L +L L L
Sbjct: 240 ---GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL 296
Query: 920 TDTEIRIL 927
D R+L
Sbjct: 297 GDEGARLL 304
Score = 30.8 bits (68), Expect = 6.8
Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 779 DAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSA---- 834
D ++ ++LK++ L L D EG + ++L C LE + + SC +A
Sbjct: 275 DLCRVLRAKESLKELSLAG-NELGD--EGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 835 NAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDV-Q 893
+ +LAQN L L +S N LE G + EL + + ++ CDV
Sbjct: 332 HFSSVLAQNRF----LLELQISNNRLEDAG---VRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 894 GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEI 924
S SSL L L +L L N L D I
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGI 415
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+++G+ G+ +++ L + C ++++ L +CCL+ +L+ L L L L LS+N L
Sbjct: 66 NELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLL 125
Query: 861 EKDGNEALHE-LIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRL 919
G + L E L+D LE+ L L + S L L P +L + N +
Sbjct: 126 GDAGLQLLCEGLLDPQCRLEK---LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Query: 920 TDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
+ +R+L +P + + L L V+SD G+
Sbjct: 183 NEAGVRVLCQGLKDSPCQ-LEALKLESCGVTSDNCRDLCGI 222
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+DI E G+ + + L PC LE ++L SC ++++ + L + + L L L N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 861 EKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQLVKLGLKNWRL 919
G+ + EL + + W C + L + L L +L L L
Sbjct: 240 ---GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL 296
Query: 920 TDTEIRIL 927
D R+L
Sbjct: 297 GDEGARLL 304
Score = 30.8 bits (68), Expect = 6.8
Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 779 DAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSA---- 834
D ++ ++LK++ L L D EG + ++L C LE + + SC +A
Sbjct: 275 DLCRVLRAKESLKELSLAG-NELGD--EGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 835 NAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDV-Q 893
+ +LAQN L L +S N LE G + EL + + ++ CDV
Sbjct: 332 HFSSVLAQNRF----LLELQISNNRLEDAG---VRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 894 GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEI 924
S SSL L L +L L N L D I
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGI 415
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+++G+ G+ +++ L + C ++++ L +CCL+ +L+ L L L L LS+N L
Sbjct: 66 NELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLL 125
Query: 861 EKDGNEALHE-LIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRL 919
G + L E L+D LE+ L L + S L L P +L + N +
Sbjct: 126 GDAGLQLLCEGLLDPQCRLEK---LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Query: 920 TDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
+ +R+L +P + + L L V+SD G+
Sbjct: 183 NEAGVRVLCQGLKDSPCQ-LEALKLESCGVTSDNCRDLCGI 222
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+DI E G+ + + L PC LE ++L SC ++++ + L + + L L L N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 861 EKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQLVKLGLKNWRL 919
G+ + EL + + W C + L + L L +L L L
Sbjct: 240 ---GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL 296
Query: 920 TDTEIRIL 927
D R+L
Sbjct: 297 GDEGARLL 304
Score = 30.8 bits (68), Expect = 6.8
Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 779 DAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSA---- 834
D ++ ++LK++ L L D EG + ++L C LE + + SC +A
Sbjct: 275 DLCRVLRAKESLKELSLAG-NELGD--EGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 835 NAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDV-Q 893
+ +LAQN L L +S N LE G + EL + + ++ CDV
Sbjct: 332 HFSSVLAQNRF----LLELQISNNRLEDAG---VRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 894 GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEI 924
S SSL L L +L L N L D I
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGI 415
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+++G+ G+ +++ L + C ++++ L +CCL+ +L+ L L L L LS+N L
Sbjct: 66 NELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLL 125
Query: 861 EKDGNEALHE-LIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRL 919
G + L E L+D LE+ L L + S L L P +L + N +
Sbjct: 126 GDAGLQLLCEGLLDPQCRLEK---LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Query: 920 TDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
+ +R+L +P + + L L V+SD G+
Sbjct: 183 NEAGVRVLCQGLKDSPCQ-LEALKLESCGVTSDNCRDLCGI 222
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+DI E G+ + + L PC LE ++L SC ++++ + L + + L L L N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 861 EKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQLVKLGLKNWRL 919
G+ + EL + + W C + L + L L +L L L
Sbjct: 240 ---GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL 296
Query: 920 TDTEIRIL 927
D R+L
Sbjct: 297 GDEGARLL 304
Score = 30.8 bits (68), Expect = 6.8
Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 779 DAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSA---- 834
D ++ ++LK++ L L D EG + ++L C LE + + SC +A
Sbjct: 275 DLCRVLRAKESLKELSLAG-NELGD--EGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 835 NAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDV-Q 893
+ +LAQN L L +S N LE G + EL + + ++ CDV
Sbjct: 332 HFSSVLAQNRF----LLELQISNNRLEDAG---VRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 894 GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEI 924
S SSL L L +L L N L D I
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGI 415
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 47.4 bits (111), Expect = 7e-05
Identities = 41/161 (25%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+++G+ G+ +++ L + C ++++ L +CCL+ +L+ L L L L LS+N L
Sbjct: 66 NELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLL 125
Query: 861 EKDGNEALHE-LIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRL 919
G + L E L+D LE+ L L + S L L P +L + N +
Sbjct: 126 GDAGLQLLCEGLLDPQCRLEK---LQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDI 182
Query: 920 TDTEIRILGAFFGKNPLKNFQQLNLAGNRVSSDGWLAFMGV 960
+ +R+L +P + + L L V+SD G+
Sbjct: 183 NEAGVRVLCQGLKDSPCQ-LEALKLESCGVTSDNCRDLCGI 222
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/128 (25%), Positives = 53/128 (41%), Gaps = 5/128 (3%)
Query: 802 SDIGE-GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYL 860
+DI E G+ + + L PC LE ++L SC ++++ + L + + L L L N L
Sbjct: 180 NDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKL 239
Query: 861 EKDGNEALHELIDRMNVLEQLTALMLPWGCDVQG-SLSSLLKHLEEVPQLVKLGLKNWRL 919
G+ + EL + + W C + L + L L +L L L
Sbjct: 240 ---GDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNEL 296
Query: 920 TDTEIRIL 927
D R+L
Sbjct: 297 GDEGARLL 304
Score = 30.8 bits (68), Expect = 6.8
Identities = 43/151 (28%), Positives = 64/151 (42%), Gaps = 15/151 (9%)
Query: 779 DAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSA---- 834
D ++ ++LK++ L L D EG + ++L C LE + + SC +A
Sbjct: 275 DLCRVLRAKESLKELSLAG-NELGD--EGARLLCETLLEPGCQLESLWVKSCSFTAACCS 331
Query: 835 NAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLPWGCDV-Q 893
+ +LAQN L L +S N LE G + EL + + ++ CDV
Sbjct: 332 HFSSVLAQNRF----LLELQISNNRLEDAG---VRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 894 GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEI 924
S SSL L L +L L N L D I
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGI 415
>gi|238908508 leucine-rich repeat and death domain-containing protein
[Homo sapiens]
Length = 860
Score = 46.6 bits (109), Expect = 1e-04
Identities = 72/315 (22%), Positives = 131/315 (41%), Gaps = 50/315 (15%)
Query: 708 LSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNLTK 767
+S K + L + + L I E H S+ NLK L + Q +++P S+ N+ +L
Sbjct: 506 ISFSKQLLHLELSENKLLIFSE-HFCSLINLKYLDLGKNQIKKIPA----SISNMISLHV 560
Query: 768 LIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQL 827
LI+ K +++C + D+ E ++ +SS+ C+L+ IQ
Sbjct: 561 LILCCNKFETFP-----------RELCTLENLQVLDLSENQ---LQKISSDICNLKGIQK 606
Query: 828 VSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALMLP 887
++ S+N L L L L++S+ K L L ++ + QL L +
Sbjct: 607 LN--FSSNQFIHFPIELCQLQSLEQLNISQIKGRK-----LTRLPGELSNMTQLKELDIS 659
Query: 888 WGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGN 947
++ + +++ E+ LV L N +++ +L L + QQLNL+GN
Sbjct: 660 -----NNAIREIPRNIGELRNLVSLHAYNNQISYLPPSLLS-------LNDLQQLNLSGN 707
Query: 948 RVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKLTFLQEARLVGWQF 1007
++ A N+ L +F L P + K Q+ + +LQ A
Sbjct: 708 NLT-----ALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARYLQRA------- 755
Query: 1008 DDDDLSVITGAFKLV 1022
D+ D ++ FK+V
Sbjct: 756 DERDEKILEKIFKIV 770
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 45.8 bits (107), Expect = 2e-04
Identities = 168/824 (20%), Positives = 305/824 (37%), Gaps = 139/824 (16%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLR-------LSRAQGGLFETLC- 217
+ +G +G GK+ L +++ + W SG +F ++F++ R+ G L + C
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQ-DRFDYLFYIHCREVSLVTQRSLGDLIMSCCP 281
Query: 218 DQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-------PQNCPE---------- 260
D I +RK + R+LFL+DG++E + C +
Sbjct: 282 DPNPPIHKIVRKPS----------RILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDIL 331
Query: 261 IEALIKENHRFKNMVIVTT---TTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKEL 317
+ +LI++ + +++TT E L+H+ +G + + +
Sbjct: 332 LSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQ 391
Query: 318 AEGLLLQIQKSRCLRNLMKTPLFVVITCA-----IQMGESEFHSHTQTTLFHTFY--DLL 370
A IQ++ L + PL I C ++ G+S + TT + F+ LL
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 371 IQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQD-----VSSVNEDVLLTTG 425
+ + G+ A L LA +G+++ K FE D + + L
Sbjct: 452 QPRGGSQEHGLCA-----HLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMN 506
Query: 426 LLCK-YTAQRFKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDIT 484
L K ++F Y F H +FQE+ A L E E T G K+ S D+T
Sbjct: 507 LFQKEVDCEKF---YSFIHMTFQEFFAA---MYYLLEEEKEGRTNVPGSRLKLPS-RDVT 559
Query: 485 STYSSLLRYTCGSSVEATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQ-SVKNTTEQ 543
+ ++ G + R L GL +R + ++ L +
Sbjct: 560 VLLENYGKFEKGYLIFVVR-------------FLFGLVNQERTSYLEKKLSCKISQQIRL 606
Query: 544 EILKAININSFV-ECGIHLYQESTSKSALSQEFEAFFQGKSLY-----INSGNIPDYLFD 597
E+LK I + + + I Q + E F Q Y IN D++
Sbjct: 607 ELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVS 666
Query: 598 FFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVS------- 650
F + NC ++ + L F E+ E+ G H++ + +PS + +
Sbjct: 667 SF-CIENC-HRVESLSLGFLHNMPK--EEEEEEKEGRHLDMV-QCVLPSSSHAACSHGLV 721
Query: 651 -----------LFFNWKQEFRTLEVTLRDFSKLNKQDIRYLGKIFS--SATSLRLQIKRC 697
LF E+ L D + L +R L + RL + RC
Sbjct: 722 NSHLTSSFCRGLFSVLSTSQSLTELDLSD-NSLGDPGMRVLCETLQHPGCNIRRLWLGRC 780
Query: 698 A---GVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGG 754
+SLVLS+ + + L +L ++ D + L G
Sbjct: 781 GLSHECCFDISLVLSSNQKLVEL-------------------DLSDNALGDFGIRLLCVG 821
Query: 755 LTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKS 814
L L NLK KL + N + L+ L + + +L + +G+ + +
Sbjct: 822 LKHLLCNLK---KLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEG 878
Query: 815 LSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDR 874
L C L+ ++L +C L+++ L+ L + L L L N L G E++ +
Sbjct: 879 LLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQ 938
Query: 875 MN-VLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNW 917
+ +L+ L + + + + +L +L EE P+L + +W
Sbjct: 939 QSCLLQNLGLSEMYFNYETKSALETL---QEEKPELTVVFEPSW 979
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7
isoform 3 [Homo sapiens]
Length = 1037
Score = 45.8 bits (107), Expect = 2e-04
Identities = 168/757 (22%), Positives = 286/757 (37%), Gaps = 115/757 (15%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFL---RLSRAQGGLFETLCDQLLD 222
++ G +G GK+TL ++ + W C ++ F+L LSR F L + D
Sbjct: 175 VLHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKELSRMGPCSFAELISK--D 230
Query: 223 IPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-------PQNCPEIE----------ALI 265
P Q + +L QR+LF++DG +E K C + E +L+
Sbjct: 231 WP---ELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLL 287
Query: 266 KENHRFKNMVIVTTTTECLRHIRQFGALTAEV---GDMTEDSAQALIREVLIKELAEGLL 322
K + ++VTT LR ++ V G + ED +R ++ A
Sbjct: 288 KRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAF 347
Query: 323 LQIQKSRCLRNLMKTPLFVVITCA---IQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHK 379
++ + L L P I C +QM + E T T F L + +
Sbjct: 348 ELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP---Q 404
Query: 380 GVAASDFIRSLDHCGDLALEGVFS-----HKFDFELQDVSSVNEDVLLTTGLLCKYTAQR 434
G +R+L LA +G+++ H+ D E V + + L +L +
Sbjct: 405 GAQLRGALRTLSL---LAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVS- 460
Query: 435 FKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYT 494
K Y F H SFQ++ L++L + E EE +G+ I D+ S R
Sbjct: 461 -KGCYSFIHLSFQQF-----LTALFYALEKEEGEDRDGHAW---DIGDVQKLLSGEERLK 511
Query: 495 CGSSVE--------ATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEIL 546
++ A K L A + GC + I +QE LQ + + L
Sbjct: 512 NPDLIQVGHFLFGLANEKRAKELEATF--GCRMSPDI------KQELLQCKAHLHANKPL 563
Query: 547 KAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCA 606
++ + C +E +K ++ K + I+ N + + F L +C
Sbjct: 564 SVTDLKEVLGCLYESQEEELAKVVVA-------PFKEISIHLTNTSEVMHCSFS-LKHCQ 615
Query: 607 SALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNW-KQEFRTLEVT 665
D KL E + I E IP NW +Q+ R+L +
Sbjct: 616 ---DLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIP--------NWARQDLRSLRL- 663
Query: 666 LRDFSKLNKQDIRYLGKIFSSATSLR-LQIKRCAGVAGSLSLVL-----STCKNIYSLMV 719
DF L FSS ++L+ L++K+ S+ ++ STC +
Sbjct: 664 WTDFCSL-----------FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIK 712
Query: 720 EASPLTIEDERHIT-----SVTNLKTLSIHDLQNQRLPGGLTDSLGNLK-NLTKLIMDNI 773
+P T + + ++T+L TL+ H + + L D L N K NL L +
Sbjct: 713 NVTPDTAYRDFCLAFIGKKTLTHL-TLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGH 771
Query: 774 KMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLS 833
E + LK + + L+ + EG + K+++ L+ + L +C L+
Sbjct: 772 CATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLT 831
Query: 834 ANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHE 870
+ K LA L KL+ L L++N + G + L E
Sbjct: 832 EASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Score = 41.6 bits (96), Expect = 0.004
Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 25/215 (11%)
Query: 706 LVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNL 765
L ++CK++ +++V + LT H+ N I D + L GL S + K L
Sbjct: 830 LTEASCKDLAAVLVVSKKLT-----HLCLAKN----PIGDTGVKFLCEGL--SYPDCK-L 877
Query: 766 TKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEI 825
L++ + + L+E L+ + L+ ++ I G+ + ++L + C+L+ +
Sbjct: 878 QTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS-INQIARGLWILCQALENPNCNLKHL 936
Query: 826 QLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALM 885
+L SC L + L L + KL LDL +N+L K G +I VL Q T +
Sbjct: 937 RLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSG------IIKLFGVLRQRTGSL 990
Query: 886 LPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLT 920
+ + K LEEV + KN +LT
Sbjct: 991 KILRLKTYETNLEIKKLLEEVKE------KNPKLT 1019
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 45.8 bits (107), Expect = 2e-04
Identities = 168/757 (22%), Positives = 286/757 (37%), Gaps = 115/757 (15%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFL---RLSRAQGGLFETLCDQLLD 222
++ G +G GK+TL ++ + W C ++ F+L LSR F L + D
Sbjct: 175 VLHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKELSRMGPCSFAELISK--D 230
Query: 223 IPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-------PQNCPEIE----------ALI 265
P Q + +L QR+LF++DG +E K C + E +L+
Sbjct: 231 WP---ELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLL 287
Query: 266 KENHRFKNMVIVTTTTECLRHIRQFGALTAEV---GDMTEDSAQALIREVLIKELAEGLL 322
K + ++VTT LR ++ V G + ED +R ++ A
Sbjct: 288 KRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAF 347
Query: 323 LQIQKSRCLRNLMKTPLFVVITCA---IQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHK 379
++ + L L P I C +QM + E T T F L + +
Sbjct: 348 ELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP---Q 404
Query: 380 GVAASDFIRSLDHCGDLALEGVFS-----HKFDFELQDVSSVNEDVLLTTGLLCKYTAQR 434
G +R+L LA +G+++ H+ D E V + + L +L +
Sbjct: 405 GAQLRGALRTLSL---LAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVS- 460
Query: 435 FKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYT 494
K Y F H SFQ++ L++L + E EE +G+ I D+ S R
Sbjct: 461 -KGCYSFIHLSFQQF-----LTALFYALEKEEGEDRDGHAW---DIGDVQKLLSGEERLK 511
Query: 495 CGSSVE--------ATRAVMKHLAAVYQHGCLLGLSIAKRPLWRQESLQSVKNTTEQEIL 546
++ A K L A + GC + I +QE LQ + + L
Sbjct: 512 NPDLIQVGHFLFGLANEKRAKELEATF--GCRMSPDI------KQELLQCKAHLHANKPL 563
Query: 547 KAININSFVECGIHLYQESTSKSALSQEFEAFFQGKSLYINSGNIPDYLFDFFEHLPNCA 606
++ + C +E +K ++ K + I+ N + + F L +C
Sbjct: 564 SVTDLKEVLGCLYESQEEELAKVVVA-------PFKEISIHLTNTSEVMHCSFS-LKHCQ 615
Query: 607 SALDFIKLDFYGGAMASWEKAAEDTGGIHMEEAPETYIPSRAVSLFFNW-KQEFRTLEVT 665
D KL E + I E IP NW +Q+ R+L +
Sbjct: 616 ---DLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIP--------NWARQDLRSLRL- 663
Query: 666 LRDFSKLNKQDIRYLGKIFSSATSLR-LQIKRCAGVAGSLSLVL-----STCKNIYSLMV 719
DF L FSS ++L+ L++K+ S+ ++ STC +
Sbjct: 664 WTDFCSL-----------FSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIK 712
Query: 720 EASPLTIEDERHIT-----SVTNLKTLSIHDLQNQRLPGGLTDSLGNLK-NLTKLIMDNI 773
+P T + + ++T+L TL+ H + + L D L N K NL L +
Sbjct: 713 NVTPDTAYRDFCLAFIGKKTLTHL-TLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGH 771
Query: 774 KMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLS 833
E + LK + + L+ + EG + K+++ L+ + L +C L+
Sbjct: 772 CATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLT 831
Query: 834 ANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHE 870
+ K LA L KL+ L L++N + G + L E
Sbjct: 832 EASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCE 868
Score = 38.1 bits (87), Expect = 0.043
Identities = 30/103 (29%), Positives = 50/103 (48%), Gaps = 10/103 (9%)
Query: 765 LTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHL----SDIGE-GMDYIVKSLSSEP 819
L L ++N ++ E LA L KK LTHL + IG+ G+ ++ + LS
Sbjct: 820 LQMLSLENCRLTEASCKDLAAVLVVSKK-----LTHLCLAKNPIGDTGVKFLCEGLSYPD 874
Query: 820 CDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEK 862
C L+ + L C ++ + L++ L L+ LDLS N + +
Sbjct: 875 CKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR 917
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 45.8 bits (107), Expect = 2e-04
Identities = 173/813 (21%), Positives = 295/813 (36%), Gaps = 145/813 (17%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFL---RLSRAQGGLFETLCDQLLD 222
++ G +G GK+TL ++ + W C ++ F+L LSR F L + D
Sbjct: 175 VLHGPAGVGKTTLAKKCMLDWTD--CNLSPTLRYAFYLSCKELSRMGPCSFAELISK--D 230
Query: 223 IPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-------PQNCPEIE----------ALI 265
P Q + +L QR+LF++DG +E K C + E +L+
Sbjct: 231 WP---ELQDDIPSILAQAQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLL 287
Query: 266 KENHRFKNMVIVTTTTECLRHIRQFGALTAEV---GDMTEDSAQALIREVLIKELAEGLL 322
K + ++VTT LR ++ V G + ED +R ++ A
Sbjct: 288 KRKMLPRAALLVTTRPRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAF 347
Query: 323 LQIQKSRCLRNLMKTPLFVVITCA---IQMGESEFHSHTQTTLFHTFYDLLIQKNKHKHK 379
++ + L L P I C +QM + E T T F L + +
Sbjct: 348 ELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRFP---Q 404
Query: 380 GVAASDFIRSLDHCGDLALEGVFS-----HKFDFELQDVSSVNEDVLLTTGLLCKYTAQR 434
G +R+L LA +G+++ H+ D E V + + L +L +
Sbjct: 405 GAQLRGALRTLSL---LAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVS- 460
Query: 435 FKPKYKFFHKSFQEYTAGRRLSSLLTSHEPEEVTKGNGYLQKMVSISDITSTYSSLLRYT 494
K Y F H SFQ++ L++L + E EE +G+ I D+ S R
Sbjct: 461 -KGCYSFIHLSFQQF-----LTALFYALEKEEGEDRDGHAW---DIGDVQKLLSGEERLK 511
Query: 495 CGSSVE--------ATRAVMKHLAAVYQHGCLLGLSI------------AKRPLW---RQ 531
++ A K L A + GC + I A +PL +
Sbjct: 512 NPDLIQVGHFLFGLANEKRAKELEATF--GCRMSPDIKQELLQCKAHLHANKPLSVTDLK 569
Query: 532 ESLQSVKNTTEQEILKAININSFVECGIHLYQES-TSKSALSQEFEAFFQGKSLYINSG- 589
E L + + E+E+ K + + F E IHL S + S + Q SL + G
Sbjct: 570 EVLGCLYESQEEELAKVV-VAPFKEISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGV 628
Query: 590 ---NIPDYLFDFFEHLPNCASALDFIKLDFYGGAMASWEKAAEDTGGIHMEE------AP 640
N D+ D N +K F + H+++ P
Sbjct: 629 FLENYMDFELDIEFESSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTP 688
Query: 641 ETYIPSRAVSLFFNWKQEF------------RTLEVTLRDFSKLNKQDIRYLGKIFSSAT 688
+T R L F K+ RT+ + L D + +K +++YL AT
Sbjct: 689 DT--AYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCAT 746
Query: 689 SLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDER--HITSVTNLKTLSIHDL 746
+ VL +++ L + A+ L E + T L + L
Sbjct: 747 PEQW---------AEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSL 797
Query: 747 QNQRLPGGLTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGE 806
+N RL + + K+L +++ + K+ K G +K +C E
Sbjct: 798 ENCRL------TEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLC-----------E 840
Query: 807 GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNE 866
G+ Y C L+ + L C ++ + L++ L L+ LDLS N + + G
Sbjct: 841 GLSY-------PDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLW 892
Query: 867 ALHELIDRMNV----LEQLTALMLPWGCDVQGS 895
L + ++ N L + ++P+ C GS
Sbjct: 893 ILCQALENPNCNLKHLRLWSCSLMPFYCQHLGS 925
Score = 41.6 bits (96), Expect = 0.004
Identities = 55/215 (25%), Positives = 95/215 (44%), Gaps = 25/215 (11%)
Query: 706 LVLSTCKNIYSLMVEASPLTIEDERHITSVTNLKTLSIHDLQNQRLPGGLTDSLGNLKNL 765
L ++CK++ +++V + LT H+ N I D + L GL S + K L
Sbjct: 802 LTEASCKDLAAVLVVSKKLT-----HLCLAKN----PIGDTGVKFLCEGL--SYPDCK-L 849
Query: 766 TKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEI 825
L++ + + L+E L+ + L+ ++ I G+ + ++L + C+L+ +
Sbjct: 850 QTLVLQQCSITKLGCRYLSEALQEACSLTNLDLS-INQIARGLWILCQALENPNCNLKHL 908
Query: 826 QLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALM 885
+L SC L + L L + KL LDL +N+L K G +I VL Q T +
Sbjct: 909 RLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSG------IIKLFGVLRQRTGSL 962
Query: 886 LPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLT 920
+ + K LEEV + KN +LT
Sbjct: 963 KILRLKTYETNLEIKKLLEEVKE------KNPKLT 991
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 45.8 bits (107), Expect = 2e-04
Identities = 70/316 (22%), Positives = 127/316 (40%), Gaps = 37/316 (11%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLRLSRAQGGLFETLCDQLLDIPG 225
+++G +G GKS L ++ + W GK +F ++F++ E L+
Sbjct: 214 VMQGAAGIGKSMLAHKVMLDWADGKLFQ-GRFDYLFYINCREMNQSATECSMQDLI-FSC 271
Query: 226 TIRKQTFMAMLLKLRQRVLFLLDGYNEFKPQ-NCPE----------------IEALIKEN 268
+ L+++ +R+LF++DG++E KP + P+ + +LI++
Sbjct: 272 WPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPWCLCWEEKRPTELLLNSLIRKK 331
Query: 269 HRFKNMVIVTTTTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIK-----ELAEGLLL 323
+ +++TT L + + V + A+ +E K E A +
Sbjct: 332 LLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAER--KEYFYKYFHNAEQAGQVFN 389
Query: 324 QIQKSRCLRNLMKTPL--FVVITCAIQM---GESEFHSHTQTTLFHTFYDLLIQKNKHKH 378
++ + L + PL +VV TC Q G + TT + Y L + + K
Sbjct: 390 YVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRTTTAVYMLYLLSLMQPKPGA 449
Query: 379 KGVAASDFIRSLDHCGDLALEGVFSHKFDFELQDVSS---VNEDVLLTTGLLCKYTAQRF 435
+ R L C LA +G+++ K FE QD+ EDV +
Sbjct: 450 PRLQPPPNQRGL--C-SLAADGLWNQKILFEEQDLRKHGLDGEDVSAFLNMNIFQKDINC 506
Query: 436 KPKYKFFHKSFQEYTA 451
+ Y F H SFQE+ A
Sbjct: 507 ERYYSFIHLSFQEFFA 522
Score = 33.1 bits (74), Expect = 1.4
Identities = 32/122 (26%), Positives = 55/122 (45%), Gaps = 4/122 (3%)
Query: 807 GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNE 866
G+ + + L C L+ ++L C +S++A + L+ L L+ +DLS N + G
Sbjct: 729 GVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMM 788
Query: 867 ALHELIDRMNVLEQLTALMLPWGCDVQ-GSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIR 925
L E + Q+ L C ++ G+ + L P LV+L L L D +R
Sbjct: 789 LLCEGLRHPQCRLQMIQLR---KCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLR 845
Query: 926 IL 927
+L
Sbjct: 846 LL 847
Score = 33.1 bits (74), Expect = 1.4
Identities = 30/104 (28%), Positives = 44/104 (42%), Gaps = 4/104 (3%)
Query: 807 GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDG-- 864
GM + + L C L+ IQL C L + A + +A L L LDL+ N LE G
Sbjct: 786 GMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLR 845
Query: 865 --NEALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEV 906
+ L + R+ L + CD S S+ + L E+
Sbjct: 846 LLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLREL 889
>gi|4502141 baculoviral IAP repeat-containing protein 2 [Homo
sapiens]
Length = 618
Score = 45.4 bits (106), Expect = 3e-04
Identities = 29/84 (34%), Positives = 49/84 (58%), Gaps = 2/84 (2%)
Query: 1 MNFIKDNSRALIQRMGMTVIKQITDDLFVWNVLNREEVNIICCEKVEQDAARGIIHMILK 60
++ I+ N AL Q++ T + I D+L NV+N++E +II + AR +I IL
Sbjct: 458 LSLIRKNRMALFQQL--TCVLPILDNLLKANVINKQEHDIIKQKTQIPLQARELIDTILV 515
Query: 61 KGSESCNLFLKSLKEWNYPLFQDL 84
KG+ + N+F LKE + L+++L
Sbjct: 516 KGNAAANIFKNCLKEIDSTLYKNL 539
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 45.1 bits (105), Expect = 3e-04
Identities = 70/327 (21%), Positives = 129/327 (39%), Gaps = 60/327 (18%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLR-------LSRAQGGLFETLC- 217
+ +G +G GK+ L +++ + W SG +F ++F++ R+ G L + C
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQ-DRFDYLFYIHCREVSLVTQRSLGDLIMSCCP 281
Query: 218 DQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-------PQNCPE---------- 260
D I +RK + R+LFL+DG++E + C +
Sbjct: 282 DPNPPIHKIVRKPS----------RILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDIL 331
Query: 261 IEALIKENHRFKNMVIVTT---TTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKEL 317
+ +LI++ + +++TT E L+H+ +G + + +
Sbjct: 332 LSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQ 391
Query: 318 AEGLLLQIQKSRCLRNLMKTPLFVVITCA-----IQMGESEFHSHTQTTLFHTFY--DLL 370
A IQ++ L + PL I C ++ G+S + TT + F+ LL
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 371 IQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQD-----VSSVNEDVLLTTG 425
+ + G+ A L LA +G+++ K FE D + + L
Sbjct: 452 QPRGGSQEHGLCA-----HLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMN 506
Query: 426 LLCK-YTAQRFKPKYKFFHKSFQEYTA 451
L K ++F Y F H +FQE+ A
Sbjct: 507 LFQKEVDCEKF---YSFIHMTFQEFFA 530
Score = 37.4 bits (85), Expect = 0.073
Identities = 40/145 (27%), Positives = 61/145 (42%), Gaps = 3/145 (2%)
Query: 807 GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNE 866
GM + ++L C++ + L C LS ++ L + KL LDLS+N L G
Sbjct: 757 GMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIR 816
Query: 867 ALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRI 926
L + ++L L L L C L L L +L + L D+ + I
Sbjct: 817 LL--CVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAI 874
Query: 927 LGAFFGKNPLKNFQQLNLAGNRVSS 951
L KNP N Q+L L + ++S
Sbjct: 875 L-CEKAKNPQCNLQKLGLVNSGLTS 898
Score = 34.3 bits (77), Expect = 0.62
Identities = 44/190 (23%), Positives = 72/190 (37%), Gaps = 32/190 (16%)
Query: 764 NLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLE 823
N+ +L + ++ E ++ L + +K+ L+ + G+ + L C+L+
Sbjct: 771 NIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLK 830
Query: 824 EIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTA 883
++ LVSCCL++ + LA L L+ L + EN L G L E
Sbjct: 831 KLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQ------- 883
Query: 884 LMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLN 943
C++Q KLGL N LT L + N +N L
Sbjct: 884 ------CNLQ-----------------KLGLVNSGLTSVCCSALSSVLSTN--QNLTHLY 918
Query: 944 LAGNRVSSDG 953
L GN + G
Sbjct: 919 LRGNTLGDKG 928
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 45.1 bits (105), Expect = 3e-04
Identities = 70/327 (21%), Positives = 129/327 (39%), Gaps = 60/327 (18%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLR-------LSRAQGGLFETLC- 217
+ +G +G GK+ L +++ + W SG +F ++F++ R+ G L + C
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQ-DRFDYLFYIHCREVSLVTQRSLGDLIMSCCP 281
Query: 218 DQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-------PQNCPE---------- 260
D I +RK + R+LFL+DG++E + C +
Sbjct: 282 DPNPPIHKIVRKPS----------RILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDIL 331
Query: 261 IEALIKENHRFKNMVIVTT---TTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKEL 317
+ +LI++ + +++TT E L+H+ +G + + +
Sbjct: 332 LSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQ 391
Query: 318 AEGLLLQIQKSRCLRNLMKTPLFVVITCA-----IQMGESEFHSHTQTTLFHTFY--DLL 370
A IQ++ L + PL I C ++ G+S + TT + F+ LL
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 371 IQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQD-----VSSVNEDVLLTTG 425
+ + G+ A L LA +G+++ K FE D + + L
Sbjct: 452 QPRGGSQEHGLCA-----HLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMN 506
Query: 426 LLCK-YTAQRFKPKYKFFHKSFQEYTA 451
L K ++F Y F H +FQE+ A
Sbjct: 507 LFQKEVDCEKF---YSFIHMTFQEFFA 530
Score = 32.7 bits (73), Expect = 1.8
Identities = 36/134 (26%), Positives = 50/134 (37%), Gaps = 32/134 (23%)
Query: 820 CDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLE 879
C+L+++ LVSCCL++ + LA L L+ L + EN L G L E
Sbjct: 770 CNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQ--- 826
Query: 880 QLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNF 939
C++Q KLGL N LT L + N +N
Sbjct: 827 ----------CNLQ-----------------KLGLVNSGLTSVCCSALSSVLSTN--QNL 857
Query: 940 QQLNLAGNRVSSDG 953
L L GN + G
Sbjct: 858 THLYLRGNTLGDKG 871
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 45.1 bits (105), Expect = 3e-04
Identities = 70/327 (21%), Positives = 129/327 (39%), Gaps = 60/327 (18%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLR-------LSRAQGGLFETLC- 217
+ +G +G GK+ L +++ + W SG +F ++F++ R+ G L + C
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQ-DRFDYLFYIHCREVSLVTQRSLGDLIMSCCP 281
Query: 218 DQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-------PQNCPE---------- 260
D I +RK + R+LFL+DG++E + C +
Sbjct: 282 DPNPPIHKIVRKPS----------RILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDIL 331
Query: 261 IEALIKENHRFKNMVIVTT---TTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKEL 317
+ +LI++ + +++TT E L+H+ +G + + +
Sbjct: 332 LSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQ 391
Query: 318 AEGLLLQIQKSRCLRNLMKTPLFVVITCA-----IQMGESEFHSHTQTTLFHTFY--DLL 370
A IQ++ L + PL I C ++ G+S + TT + F+ LL
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 371 IQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQD-----VSSVNEDVLLTTG 425
+ + G+ A L LA +G+++ K FE D + + L
Sbjct: 452 QPRGGSQEHGLCA-----HLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMN 506
Query: 426 LLCK-YTAQRFKPKYKFFHKSFQEYTA 451
L K ++F Y F H +FQE+ A
Sbjct: 507 LFQKEVDCEKF---YSFIHMTFQEFFA 530
Score = 37.4 bits (85), Expect = 0.073
Identities = 40/145 (27%), Positives = 61/145 (42%), Gaps = 3/145 (2%)
Query: 807 GMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNE 866
GM + ++L C++ + L C LS ++ L + KL LDLS+N L G
Sbjct: 757 GMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIR 816
Query: 867 ALHELIDRMNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRI 926
L + ++L L L L C L L L +L + L D+ + I
Sbjct: 817 LL--CVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAI 874
Query: 927 LGAFFGKNPLKNFQQLNLAGNRVSS 951
L KNP N Q+L L + ++S
Sbjct: 875 L-CEKAKNPQCNLQKLGLVNSGLTS 898
Score = 34.3 bits (77), Expect = 0.62
Identities = 44/190 (23%), Positives = 72/190 (37%), Gaps = 32/190 (16%)
Query: 764 NLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLE 823
N+ +L + ++ E ++ L + +K+ L+ + G+ + L C+L+
Sbjct: 771 NIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLK 830
Query: 824 EIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTA 883
++ LVSCCL++ + LA L L+ L + EN L G L E
Sbjct: 831 KLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQ------- 883
Query: 884 LMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLN 943
C++Q KLGL N LT L + N +N L
Sbjct: 884 ------CNLQ-----------------KLGLVNSGLTSVCCSALSSVLSTN--QNLTHLY 918
Query: 944 LAGNRVSSDG 953
L GN + G
Sbjct: 919 LRGNTLGDKG 928
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 45.1 bits (105), Expect = 3e-04
Identities = 70/327 (21%), Positives = 129/327 (39%), Gaps = 60/327 (18%)
Query: 166 IIEGESGKGKSTLLQRIAMLWGSGKCKALTKFKFVFFLR-------LSRAQGGLFETLC- 217
+ +G +G GK+ L +++ + W SG +F ++F++ R+ G L + C
Sbjct: 223 VFQGAAGIGKTILARKMMLDWASGTLYQ-DRFDYLFYIHCREVSLVTQRSLGDLIMSCCP 281
Query: 218 DQLLDIPGTIRKQTFMAMLLKLRQRVLFLLDGYNEFK-------PQNCPE---------- 260
D I +RK + R+LFL+DG++E + C +
Sbjct: 282 DPNPPIHKIVRKPS----------RILFLMDGFDELQGAFDEHIGPLCTDWQKAERGDIL 331
Query: 261 IEALIKENHRFKNMVIVTT---TTECLRHIRQFGALTAEVGDMTEDSAQALIREVLIKEL 317
+ +LI++ + +++TT E L+H+ +G + + +
Sbjct: 332 LSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILGFSEAKRKEYFFKYFSDEAQ 391
Query: 318 AEGLLLQIQKSRCLRNLMKTPLFVVITCA-----IQMGESEFHSHTQTTLFHTFY--DLL 370
A IQ++ L + PL I C ++ G+S + TT + F+ LL
Sbjct: 392 ARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSLAQTSKTTTAVYVFFLSSLL 451
Query: 371 IQKNKHKHKGVAASDFIRSLDHCGDLALEGVFSHKFDFELQD-----VSSVNEDVLLTTG 425
+ + G+ A L LA +G+++ K FE D + + L
Sbjct: 452 QPRGGSQEHGLCA-----HLWGLCSLAADGIWNQKILFEESDLRNHGLQKADVSAFLRMN 506
Query: 426 LLCK-YTAQRFKPKYKFFHKSFQEYTA 451
L K ++F Y F H +FQE+ A
Sbjct: 507 LFQKEVDCEKF---YSFIHMTFQEFFA 530
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,957,983
Number of Sequences: 37866
Number of extensions: 1484864
Number of successful extensions: 4142
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 47
Number of HSP's successfully gapped in prelim test: 79
Number of HSP's that attempted gapping in prelim test: 3870
Number of HSP's gapped (non-prelim): 283
length of query: 1024
length of database: 18,247,518
effective HSP length: 112
effective length of query: 912
effective length of database: 14,006,526
effective search space: 12773951712
effective search space used: 12773951712
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.