Search of human proteins with 40549448

Search of human proteins with 40549448

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
[Homo sapiens]
         (839 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2 [...  1724   0.0  
gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1 ...  1696   0.0  
gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1 ...   935   0.0  
gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]    879   0.0  
gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2 ...   277   3e-74
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          108   2e-23
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          108   2e-23
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   106   8e-23
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...   106   1e-22
gi|5729856 GRB2-related adaptor protein [Homo sapiens]                104   4e-22
gi|23308553 spermatogenesis associated 13 [Homo sapiens]              103   9e-22
gi|71274148 pleckstrin homology domain containing, family G (wit...   102   1e-21
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...    99   2e-20
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...    99   2e-20
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]              98   4e-20
gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Hom...    92   3e-18
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    85   2e-16
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    85   3e-16
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]    85   3e-16
gi|55749621 pleckstrin homology domain containing, family G, mem...    84   4e-16
gi|166197690 neuronal guanine nucleotide exchange factor isoform...    83   9e-16
gi|166197688 neuronal guanine nucleotide exchange factor isoform...    83   9e-16
gi|224586880 Ras protein-specific guanine nucleotide-releasing f...    79   2e-14
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa...    79   2e-14
gi|163644325 MCF.2 cell line derived transforming sequence-like ...    78   4e-14
gi|163644323 MCF.2 cell line derived transforming sequence-like ...    78   4e-14
gi|153791628 MCF.2 cell line derived transforming sequence isofo...    78   4e-14
gi|153791325 MCF.2 cell line derived transforming sequence isofo...    78   4e-14
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                77   9e-14
gi|39930351 dynamin binding protein [Homo sapiens]                     77   9e-14

>gi|40549448 vav 2 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 839

 Score = 1724 bits (4464), Expect = 0.0
 Identities = 839/839 (100%), Positives = 839/839 (100%)

Query: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
           MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
Sbjct: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60

Query: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
           NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
Sbjct: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120

Query: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV 180
           AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
Sbjct: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV 180

Query: 181 QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE 240
           QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE
Sbjct: 181 QQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFINLE 240

Query: 241 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE 300
           DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE
Sbjct: 241 DLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE 300

Query: 301 DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA 360
           DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA
Sbjct: 301 DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA 360

Query: 361 MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR 420
           MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR
Sbjct: 361 MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDR 420

Query: 421 YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGF 480
           YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGF
Sbjct: 421 YLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGF 480

Query: 481 QFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQ 540
           QFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQ
Sbjct: 481 QFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGTFYQ 540

Query: 541 GYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLT 600
           GYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLT
Sbjct: 541 GYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGNPAPPGKPVLT 600

Query: 601 FQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTA 660
           FQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTA
Sbjct: 601 FQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDYTA 660

Query: 661 YPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIH 720
           YPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIH
Sbjct: 661 YPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDNWIH 720

Query: 721 ITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIG 780
           ITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIG
Sbjct: 721 ITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPRVIG 780

Query: 781 TAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ 839
           TAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
Sbjct: 781 TAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ 839


>gi|197304715 vav 2 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 878

 Score = 1696 bits (4392), Expect = 0.0
 Identities = 839/878 (95%), Positives = 839/878 (95%), Gaps = 39/878 (4%)

Query: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
           MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI
Sbjct: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60

Query: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
           NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI
Sbjct: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120

Query: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV 180
           AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV
Sbjct: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEV 180

Query: 181 QQPM-----KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV 235
           QQPM     KMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV
Sbjct: 181 QQPMIRYMQKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAV 240

Query: 236 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL 295
           FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL
Sbjct: 241 FINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQL 300

Query: 296 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK 355
           LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK
Sbjct: 301 LASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLK 360

Query: 356 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH 415
           EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH
Sbjct: 361 EALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNH 420

Query: 416 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKK-----WSYGFY 470
           TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKK     WSYGFY
Sbjct: 421 TKQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKSHGKMWSYGFY 480

Query: 471 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC 530
           LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC
Sbjct: 481 LIHLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKAC 540

Query: 531 KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN 590
           KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN
Sbjct: 541 KMFLRGTFYQGYMCTKCGVGAHKECLEVIPPCKFTSPADLDASGAGPGPKMVAMQNYHGN 600

Query: 591 PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR 650
           PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR
Sbjct: 601 PAPPGKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISR 660

Query: 651 PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI 710
           PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI
Sbjct: 661 PPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAISIKFNDEVKHI 720

Query: 711 KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR 770
           KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR
Sbjct: 721 KVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSR 780

Query: 771 SP-----------------------------VFTPRVIGTAVARYNFAARDMRELSLREG 801
           SP                             VFTPRVIGTAVARYNFAARDMRELSLREG
Sbjct: 781 SPASCASYNFSFLSPQGLSFASQGPSAPFWSVFTPRVIGTAVARYNFAARDMRELSLREG 840

Query: 802 DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ 839
           DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ
Sbjct: 841 DVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVEEEGIQ 878


>gi|120432044 vav 3 guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 847

 Score =  935 bits (2417), Expect = 0.0
 Identities = 463/859 (53%), Positives = 621/859 (72%), Gaps = 36/859 (4%)

Query: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
           ME W+QC +WLI CKVLP NHRV W SA VFDLAQ LRDGVLLCQLL+NL   SI+LK+I
Sbjct: 1   MEPWKQCAQWLIHCKVLPTNHRVTWDSAQVFDLAQTLRDGVLLCQLLNNLRAHSINLKEI 60

Query: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
           N RPQMSQFLCLKNIRTFL  C + FG+R SELF+ FDLFDVRDFGKVI  +SRLS   I
Sbjct: 61  NLRPQMSQFLCLKNIRTFLTACCETFGMRKSELFEAFDLFDVRDFGKVIETLSRLSRTPI 120

Query: 121 AQNKGIRPFPSEETTENDDDVYRSLEELADEH--DLGEDIYDCVPCEDGGDDIYEDIIKV 178
           A   GIRPFP+EE+  ND+D+Y+ L +L DE   +  ED+YDCV  ED G ++YED++K 
Sbjct: 121 ALATGIRPFPTEESI-NDEDIYKGLPDLIDETLVEDEEDLYDCVYGEDEGGEVYEDLMKA 179

Query: 179 EVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFIN 238
           E     K    E+D R+CCL EI++TE KY  TLE IEK +M+PL+  L+ A+  +VFIN
Sbjct: 180 EEAHQPKC--PENDIRSCCLAEIKQTEEKYTETLESIEKYFMAPLKRFLTAAEFDSVFIN 237

Query: 239 LEDLIKVHHSFLRAIDVSVM-VGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLA 297
           + +L+K+H + ++ I  S++      L +VF+++KERL+IYG+YCS +E A ++L+ +  
Sbjct: 238 IPELVKLHRNLMQEIHDSIVNKNDQNLYQVFINYKERLVIYGQYCSGVESAISSLDYISK 297

Query: 298 SREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEA 357
           ++ED + K+EEC+ +  +GKF L+DLLVVPMQRVLKYHLLL+EL+ H+ +  E+  LK A
Sbjct: 298 TKEDVKLKLEECSKRANNGKFTLRDLLVVPMQRVLKYHLLLQELVKHTTDPTEKANLKLA 357

Query: 358 LEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTK 417
           L+AM+DLA Y+NEVKRD ETLR+I +FQ SIENL   +  FGRP+ DGE+++ ++  HTK
Sbjct: 358 LDAMKDLAQYVNEVKRDNETLREIKQFQLSIENLNQPVLLFGRPQGDGEIRITTLDKHTK 417

Query: 418 QDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGK 477
           Q+R++FLFD  VIVCKRKG +YE+KEII+L  +K+ ++P  +K+ KKWSYGFYLIH QG+
Sbjct: 418 QERHIFLFDLAVIVCKRKGDNYEMKEIIDLQQYKIANNPTTDKENKKWSYGFYLIHTQGQ 477

Query: 478 QGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRGT 537
            G +F+CKT+D+K+KW+EQFEMA+SNI+PD A++N H F+M+TF + T+CK C+M LRGT
Sbjct: 478 NGLEFYCKTKDLKKKWLEQFEMALSNIRPDYADSNFHDFKMHTFTRVTSCKVCQMLLRGT 537

Query: 538 FYQGYMCTKCGVGAHKECLEVIPPC---------------KFTSPADLDASGAGPG-PKM 581
           FYQGY+C KCG  AHKECL  +  C               K T+          PG PKM
Sbjct: 538 FYQGYLCFKCGARAHKECLGRVDNCGRVNSGEQGTLKLPEKRTNGLRRTPKQVDPGLPKM 597

Query: 582 VAMQNYHGNPAPP--GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKP 639
             ++NY G P P     P L  Q GD +ELL+GD  S +W+GR + + + G+FPS +VKP
Sbjct: 598 QVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFPSDAVKP 657

Query: 640 CPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAI 699
           CP   +P         +DY+  PW+AG MER Q +  L +  + TYL+R R  E+  +AI
Sbjct: 658 CPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKESGEYAI 708

Query: 700 SIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKS 759
           SIK+N+E KHIK++ +D + HI E +KF SL+ELVEYY+ HSLKE F+ LDTTL++PYK 
Sbjct: 709 SIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTLQFPYKE 768

Query: 760 RERSASRASSR--SPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWW 817
            E SA +  +R  + + +P+V+G A+ARY+F ARDMRELSL +GDVV+IY+++  + GWW
Sbjct: 769 PEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMSAN-GWW 827

Query: 818 KGETNGRIGWFPSTYVEEE 836
           +GE NGR+GWFPSTYVEE+
Sbjct: 828 RGEVNGRVGWFPSTYVEED 846


>gi|7108367 vav 1 guanine nucleotide exchange factor [Homo sapiens]
          Length = 845

 Score =  879 bits (2270), Expect = 0.0
 Identities = 442/856 (51%), Positives = 592/856 (69%), Gaps = 36/856 (4%)

Query: 1   MEQWRQCGRWLIDCKVLPPNHRVVWPSAVVFDLAQALRDGVLLCQLLHNLSPGSIDLKDI 60
           ME WRQC  WLI C+VLPP+HRV W  A V +LAQALRDGVLLCQLL+NL P +I+L+++
Sbjct: 1   MELWRQCTHWLIQCRVLPPSHRVTWDGAQVCELAQALRDGVLLCQLLNNLLPHAINLREV 60

Query: 61  NFRPQMSQFLCLKNIRTFLKVCHDKFGLRNSELFDPFDLFDVRDFGKVISAVSRLSLHSI 120
           N RPQMSQFLCLKNIRTFL  C +KFGL+ SELF+ FDLFDV+DFGKVI  +S LS   I
Sbjct: 61  NLRPQMSQFLCLKNIRTFLSTCCEKFGLKRSELFEAFDLFDVQDFGKVIYTLSALSWTPI 120

Query: 121 AQNKGIRPFPSEETTENDDDVYRSL-EELADEHDLGEDIYDCVPCEDG-GDDIYEDIIKV 178
           AQN+GI PFP+EE +  D+D+Y  L +++ D  +  ED+YDCV  E+  GD+IYED+++ 
Sbjct: 121 AQNRGIMPFPTEEESVGDEDIYSGLSDQIDDTVEEDEDLYDCVENEEAEGDEIYEDLMRS 180

Query: 179 E-VQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPADMAAVFI 237
           E V  P KM  TE DKR CCL EIQ+TE KY  TL  I+++++ PL+  L P D+  +FI
Sbjct: 181 EPVSMPPKM--TEYDKRCCCLREIQQTEEKYTDTLGSIQQHFLKPLQRFLKPQDIEIIFI 238

Query: 238 NLEDLIKVHHSFLRAIDVSVMV-GGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLL 296
           N+EDL++VH  FL+ +  ++   G + L +VF+ +KER L+YG YCS +E A   L+++ 
Sbjct: 239 NIEDLLRVHTHFLKEMKEALGTPGAANLYQVFIKYKERFLVYGRYCSQVESASKHLDRVA 298

Query: 297 ASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKE 356
           A+RED + K+EEC+ +  +G+F L+DLL+VPMQRVLKYHLLL+EL+ H+ E  E++ L+ 
Sbjct: 299 AAREDVQMKLEECSQRANNGRFTLRDLLMVPMQRVLKYHLLLQELVKHTQEAMEKENLRL 358

Query: 357 ALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHT 416
           AL+AM+DLA  +NEVKRD ETLR+I+ FQ SIENL   L  +GRPKIDGELK+ S+   +
Sbjct: 359 ALDAMRDLAQCVNEVKRDNETLRQITNFQLSIENLDQSLAHYGRPKIDGELKITSVERRS 418

Query: 417 KQDRYLFLFDKVVIVCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQG 476
           K DRY FL DK +++CKR+G SY+LK+ + L   ++ DD   ++D KKWS+ F LI  QG
Sbjct: 419 KMDRYAFLLDKALLICKRRGDSYDLKDFVNLHSFQVRDDSSGDRDNKKWSHMFLLIEDQG 478

Query: 477 KQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDKANANHHSFQMYTFDKTTNCKACKMFLRG 536
            QG++ F KT ++K+KWMEQFEMA+SNI P+ A AN H FQM++F++TT+CKAC+M LRG
Sbjct: 479 AQGYELFFKTRELKKKWMEQFEMAISNIYPENATANGHDFQMFSFEETTSCKACQMLLRG 538

Query: 537 TFYQGYMCTKCGVGAHKECLEVIPPC--------------KFTSPADLDASGAGPGPKMV 582
           TFYQGY C +C   AHKECL  +PPC              K    A          PKM 
Sbjct: 539 TFYQGYRCHRCRASAHKECLGRVPPCGRHGQDFPGTMKKDKLHRRAQDKKRNELGLPKME 598

Query: 583 AMQNYHGNPAPPGK--PVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPC 640
             Q Y+G P PPG   P L    GD++EL + + E  WWEGR   T + G+FP + VKP 
Sbjct: 599 VFQEYYGLPPPPGAIGPFLRLNPGDIVELTKAEAEQNWWEGRNTSTNEIGWFPCNRVKPY 658

Query: 641 PVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAEAERFAIS 700
                  +  PP    D + + W+AG MER   +++L + + GT+L+R+R  +A  FAIS
Sbjct: 659 -------VHGPPQ---DLSVHLWYAGPMERAGAESILANRSDGTFLVRQRVKDAAEFAIS 708

Query: 701 IKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSR 760
           IK+N EVKHIK++  +    ITE K F  L ELVE+YQ +SLK+ FK LDTTL++P+K  
Sbjct: 709 IKYNVEVKHIKIMTAEGLYRITEKKAFRGLTELVEFYQQNSLKDCFKSLDTTLQFPFKEP 768

Query: 761 ERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGE 820
           E+   R  SR  V + +  GTA ARY+F ARD  ELSL+EGD+++I ++  G QGWW+GE
Sbjct: 769 EK---RTISRPAVGSTKYFGTAKARYDFCARDRSELSLKEGDIIKILNK-KGQQGWWRGE 824

Query: 821 TNGRIGWFPSTYVEEE 836
             GR+GWFP+ YVEE+
Sbjct: 825 IYGRVGWFPANYVEED 840


>gi|120432042 vav 3 guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 287

 Score =  277 bits (708), Expect = 3e-74
 Identities = 135/265 (50%), Positives = 186/265 (70%), Gaps = 15/265 (5%)

Query: 577 PG-PKMVAMQNYHGNPAPP--GKPVLTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFP 633
           PG PKM  ++NY G P P     P L  Q GD +ELL+GD  S +W+GR + + + G+FP
Sbjct: 32  PGLPKMQVIRNYSGTPPPALHEGPPLQLQAGDTVELLKGDAHSLFWQGRNLASGEVGFFP 91

Query: 634 SSSVKPCPVDGRPPISRPPSREIDYTAYPWFAGNMERQQTDNLLKSHASGTYLIRERPAE 693
           S +VKPCP   +P         +DY+  PW+AG MER Q +  L +  + TYL+R R  E
Sbjct: 92  SDAVKPCPCVPKP---------VDYSCQPWYAGAMERLQAETELINRVNSTYLVRHRTKE 142

Query: 694 AERFAISIKFNDEVKHIKVVEKDNWIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTL 753
           +  +AISIK+N+E KHIK++ +D + HI E +KF SL+ELVEYY+ HSLKE F+ LDTTL
Sbjct: 143 SGEYAISIKYNNEAKHIKILTRDGFFHIAENRKFKSLMELVEYYKHHSLKEGFRTLDTTL 202

Query: 754 KYPYKSRERSASRASSR--SPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIG 811
           ++PYK  E SA +  +R  + + +P+V+G A+ARY+F ARDMRELSL +GDVV+IY+++ 
Sbjct: 203 QFPYKEPEHSAGQRGNRAGNSLLSPKVLGIAIARYDFCARDMRELSLLKGDVVKIYTKMS 262

Query: 812 GDQGWWKGETNGRIGWFPSTYVEEE 836
            + GWW+GE NGR+GWFPSTYVEE+
Sbjct: 263 AN-GWWRGEVNGRVGWFPSTYVEED 286


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score =  108 bits (271), Expect = 2e-23
 Identities = 85/258 (32%), Positives = 131/258 (50%), Gaps = 19/258 (7%)

Query: 194 RNCCLLEIQETEAKYYRTLEDIEKNYMSPL-RLVLSPAD-------MAAVFINLEDLIKV 245
           R C L E+Q+TE  Y  TLE +   ++  + +   S  D       +  +F N+ED++ V
Sbjct: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83

Query: 246 HHSFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 302
           H  FL+ ++  +    +   +V   FL FK++  IY EYCS+ E AQ  L +L   R   
Sbjct: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT-I 142

Query: 303 RQKVEECTLKV--QDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAER-PERQQLKEALE 359
           R  +  C L    ++    L+  LV P+QR+ KY L+LKELL  +  +  +   + EAL+
Sbjct: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 360 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 417
           AM+ +   INE KR  E L  + E+QS IE  +     +      + G L    I +   
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVL--LKISSGNI 260

Query: 418 QDRYLFLFDKVVIVCKRK 435
           Q+R  FLFD +++ CKRK
Sbjct: 261 QERVFFLFDNLLVYCKRK 278


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score =  108 bits (271), Expect = 2e-23
 Identities = 85/258 (32%), Positives = 131/258 (50%), Gaps = 19/258 (7%)

Query: 194 RNCCLLEIQETEAKYYRTLEDIEKNYMSPL-RLVLSPAD-------MAAVFINLEDLIKV 245
           R C L E+Q+TE  Y  TLE +   ++  + +   S  D       +  +F N+ED++ V
Sbjct: 24  RVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAV 83

Query: 246 HHSFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 302
           H  FL+ ++  +    +   +V   FL FK++  IY EYCS+ E AQ  L +L   R   
Sbjct: 84  HKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNKIRT-I 142

Query: 303 RQKVEECTLKV--QDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAER-PERQQLKEALE 359
           R  +  C L    ++    L+  LV P+QR+ KY L+LKELL  +  +  +   + EAL+
Sbjct: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 360 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 417
           AM+ +   INE KR  E L  + E+QS IE  +     +      + G L    I +   
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVL--LKISSGNI 260

Query: 418 QDRYLFLFDKVVIVCKRK 435
           Q+R  FLFD +++ CKRK
Sbjct: 261 QERVFFLFDNLLVYCKRK 278


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  106 bits (265), Expect = 8e-23
 Identities = 84/260 (32%), Positives = 129/260 (49%), Gaps = 23/260 (8%)

Query: 194 RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLV--------LSPADMAAVFINLEDLIKV 245
           R C L EI  TE  Y  TL  ++  ++  +R          L+  ++  +F N+ED+++V
Sbjct: 50  RLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEV 109

Query: 246 HHSFLRAIDVSVMVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 302
           H  FL A++  +     +   L  VFL FK++  +Y EYCS+ E A   L +L       
Sbjct: 110 HKDFLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVEL-NKIPTV 168

Query: 303 RQKVEECTL----KVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHS-AERPERQQLKEA 357
           R  +  C L    K  D    L+  L+ P+QR+ KY LLLKEL   +  + P+   ++ A
Sbjct: 169 RAFLLSCMLLGGRKTTD--IPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSA 226

Query: 358 LEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNH 415
           L+AM+ +   INE KR  E L  + + QS IE  +     +   +  + G L   S  N 
Sbjct: 227 LQAMKTVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGN- 285

Query: 416 TKQDRYLFLFDKVVIVCKRK 435
             Q+R  FLFD +++ CKRK
Sbjct: 286 -IQERAFFLFDNLLVYCKRK 304


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score =  106 bits (264), Expect = 1e-22
 Identities = 81/253 (32%), Positives = 129/253 (50%), Gaps = 14/253 (5%)

Query: 200 EIQETEAKYYRTLEDIEKNYMSPLR----LVLSPADMAAVFINLEDLIKVHHSFLRAIDV 255
           EI ETE  Y R L  I ++Y+ PL     L LS   +  +F N+ED+ +     L  ++ 
Sbjct: 109 EIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLEDLEN 168

Query: 256 SVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQD 315
           S   GG  +A+ F+   E   IY  YC +   +   L +L  S       ++E   +++ 
Sbjct: 169 SSSAGG--IAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLS-PPAALWLQERQAQLRH 225

Query: 316 GKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERP---ERQQLKEALEAMQDLAMYINEVK 372
               LQ  L+ P+QR+LKYHLLL+EL  H AE P    R+ ++EA+ +M  +A YIN++K
Sbjct: 226 S-LPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTAVAWYINDMK 284

Query: 373 RDKETLRKISEFQSSIEN-LQVKLEEFGRPKIDGELKVRSIVNHTKQ--DRYLFLFDKVV 429
           R +E   ++ E Q  +      +L  FG   ++G  +         +  +R LFLF +++
Sbjct: 285 RKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAFRGGGGGGPRLRGGERLLFLFSRML 344

Query: 430 IVCKRKGYSYELK 442
           +V KR+G  Y  K
Sbjct: 345 LVAKRRGLEYTYK 357


>gi|5729856 GRB2-related adaptor protein [Homo sapiens]
          Length = 217

 Score =  104 bits (259), Expect = 4e-22
 Identities = 63/237 (26%), Positives = 117/237 (49%), Gaps = 41/237 (17%)

Query: 599 LTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDY 658
           L F  GD L++L  + +  W++  L      G+ P + ++  P                 
Sbjct: 17  LAFNKGDTLKILNMEDDQNWYKAELRGVE--GFIPKNYIRVKP----------------- 57

Query: 659 TAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 717
             +PW++G + RQ  + +L K +  G +LIRE  +    F++S+ + D+V+H KV+ + +
Sbjct: 58  --HPWYSGRISRQLAEEILMKRNHLGAFLIRESESSPGEFSVSVNYGDQVQHFKVLREAS 115

Query: 718 WIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPR 777
             +    +KF+SL ELV++Y+  ++    K+    L+                 P+    
Sbjct: 116 GKYFLWEEKFNSLNELVDFYRTTTIA---KKRQIFLR--------------DEEPLLKSP 158

Query: 778 VIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834
               A A+++F+A+D  +LS R GD++ +  R   D  WW+G + GR+G+FP +YV+
Sbjct: 159 GACFAQAQFDFSAQDPSQLSFRRGDIIEVLER--PDPHWWRGRSCGRVGFFPRSYVQ 213



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 19/52 (36%), Positives = 31/52 (59%), Gaps = 1/52 (1%)

Query: 782 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833
           +VA Y+F A +  EL+  +GD ++I + +  DQ W+K E  G  G+ P  Y+
Sbjct: 3   SVALYSFQATESDELAFNKGDTLKILN-MEDDQNWYKAELRGVEGFIPKNYI 53


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score =  103 bits (256), Expect = 9e-22
 Identities = 93/336 (27%), Positives = 156/336 (46%), Gaps = 30/336 (8%)

Query: 194 RNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKVHHSFL 250
           R   + EI +TE  Y + L DI + Y+   R    + + A +A +F N+ED+ K    FL
Sbjct: 241 RTNVIREIMDTERVYIKHLRDICEGYIRQCRKHTGMFTVAQLATIFGNIEDIYKFQRKFL 300

Query: 251 RAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVE 307
           + ++         L+++   FL  +E   IY EYC++   A   L  L+   + +R   E
Sbjct: 301 KDLEKQYNKEEPHLSEIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQGK-YRHFFE 359

Query: 308 ECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQDLAM 366
            C L  Q     +   L+ P+Q++ KY L L ELL ++  E  +   +K A EAM+++A 
Sbjct: 360 ACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVAC 419

Query: 367 YINEVKRDKETLRKISEFQSSI---ENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLF 423
            INE KR  E++ KI+ +Q SI   E L + L+        GEL  +       Q R  F
Sbjct: 420 LINERKRKLESIDKIARWQVSIVGWEGLDI-LDRSSELIHSGEL-TKITKQGKSQQRTFF 477

Query: 424 LFDKVVIVCKR----------KG-YSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLI 472
           LFD  ++ CK+          KG    +  E+++L   +  D  ++ K+       F L+
Sbjct: 478 LFDHQLVSCKKDLLRRDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKN------AFKLV 531

Query: 473 HLQGKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK 508
                + + F  K ++ K +W++        ++ DK
Sbjct: 532 SRTTDEVYLFCAKKQEDKARWLQACADERRRVQEDK 567



 Score = 37.7 bits (86), Expect = 0.045
 Identities = 16/52 (30%), Positives = 28/52 (53%), Gaps = 2/52 (3%)

Query: 782 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833
           A A ++    D +EL  + GDV+++      D  WW G +  +  WFP+++V
Sbjct: 152 AEALWDHVTMDDQELGFKAGDVIQVLEASNKD--WWWGRSEDKEAWFPASFV 201


>gi|71274148 pleckstrin homology domain containing, family G (with
           RhoGef domain) member 1 [Homo sapiens]
          Length = 1385

 Score =  102 bits (255), Expect = 1e-21
 Identities = 82/305 (26%), Positives = 155/305 (50%), Gaps = 26/305 (8%)

Query: 200 EIQETEAKYYRTLEDIEKNYMSPLR----LVLSPADMAAVFINLEDLIKVHHSFLRAIDV 255
           EI ETE  Y + L+ I ++Y+  +R    L L   + +A+F N++D+   +   L+ ++ 
Sbjct: 120 EILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQDLE- 178

Query: 256 SVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASR---EDFRQKVEECTLK 312
           +       +A+ F+   E   IY +YC++   +   L + + ++   + FR++ E  TLK
Sbjct: 179 NCENDPVAIAECFVSKSEEFHIYTQYCTNYPRSVAVLTECMRNKILAKFFRERQE--TLK 236

Query: 313 VQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQ-LKEALEAMQDLAMYINEV 371
                  L   L+ P+QR+LKYHLLL E+ +H  +  E    + +A++ MQ +A +IN++
Sbjct: 237 ---HSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQRVAWHINDM 293

Query: 372 KRDKETLRKISEFQSSIENLQ-VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVI 430
           KR  E   ++ E QS + N +   L  +G   ++G  +++      K +R LFLFDK+++
Sbjct: 294 KRKHEHAVRLQEIQSLLTNWKGPDLTSYGELVLEGTFRIQ----RAKNERTLFLFDKLLL 349

Query: 431 VCKRKGYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQG-KQGFQFFCKTEDM 489
           + K++  ++  K       H +  + M  + + K    F + H +  K       K++  
Sbjct: 350 ITKKRDDTFTYKA------HILCGNLMLVEVIPKEPLSFSVFHYKNPKLQHTVQAKSQQD 403

Query: 490 KRKWM 494
           KR W+
Sbjct: 404 KRLWV 408


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 78/257 (30%), Positives = 126/257 (49%), Gaps = 14/257 (5%)

Query: 189 TEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKV 245
           ++D  R   + EI  TE  Y + L DI + Y+   R    + S   +  +F N+ED+ + 
Sbjct: 280 SKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRC 339

Query: 246 HHSFLRAIDVSVMVGG---STLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 302
             +F++A++          S L   FL+ +    IY EYC++  +A   L++L      +
Sbjct: 340 QKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRL-TKLSKY 398

Query: 303 RQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKE---ALE 359
               E C L  +     L   L+ P+Q++ KY L L ELL ++   P+ +  K+   AL 
Sbjct: 399 VYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYT--HPQHRDFKDVEAALH 456

Query: 360 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 417
           AM+++A  INE KR  E + KI+++QSSIE+ + +  L         GEL   +      
Sbjct: 457 AMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKS 516

Query: 418 QDRYLFLFDKVVIVCKR 434
           Q R  FLFD  +I CK+
Sbjct: 517 QQRMFFLFDHQLIYCKK 533



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 782 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833
           A A ++    D +EL  + GDV+ +      +  WW G      GWFP+++V
Sbjct: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNRE--WWWGRVADGEGWFPASFV 248


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 78/257 (30%), Positives = 126/257 (49%), Gaps = 14/257 (5%)

Query: 189 TEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKV 245
           ++D  R   + EI  TE  Y + L DI + Y+   R    + S   +  +F N+ED+ + 
Sbjct: 280 SKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQLRTIFGNIEDIYRC 339

Query: 246 HHSFLRAIDVSVMVGG---STLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDF 302
             +F++A++          S L   FL+ +    IY EYC++  +A   L++L      +
Sbjct: 340 QKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRL-TKLSKY 398

Query: 303 RQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKE---ALE 359
               E C L  +     L   L+ P+Q++ KY L L ELL ++   P+ +  K+   AL 
Sbjct: 399 VYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYT--HPQHRDFKDVEAALH 456

Query: 360 AMQDLAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTK 417
           AM+++A  INE KR  E + KI+++QSSIE+ + +  L         GEL   +      
Sbjct: 457 AMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQPQAKS 516

Query: 418 QDRYLFLFDKVVIVCKR 434
           Q R  FLFD  +I CK+
Sbjct: 517 QQRMFFLFDHQLIYCKK 533



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 2/52 (3%)

Query: 782 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833
           A A ++    D +EL  + GDV+ +      +  WW G      GWFP+++V
Sbjct: 199 AEALWDHVTMDDQELGFKAGDVIEVMDATNRE--WWWGRVADGEGWFPASFV 248


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score = 97.8 bits (242), Expect = 4e-20
 Identities = 82/332 (24%), Positives = 157/332 (47%), Gaps = 15/332 (4%)

Query: 191 DDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL---VLSPADMAAVFINLEDLIKVHH 247
           D  R   + EI  TE  Y + L+DI + Y+   R    + S   +  +F N+ED+ +   
Sbjct: 101 DQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDMFSDEQLKVIFGNIEDIYRFQM 160

Query: 248 SFLRAIDVSVMVGGSTLAKV---FLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQ 304
            F+R ++         L+++   FL+ ++   IY EYC++   A   L++L+     ++ 
Sbjct: 161 GFVRDLEKQYNNDDPHLSEIGPCFLEHQDGFWIYSEYCNNHLDACMELSKLMKDSR-YQH 219

Query: 305 KVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSA-ERPERQQLKEALEAMQD 363
             E C L  Q     +   L+ P+Q++ KY L L ELL ++A +  + + +  AL  M++
Sbjct: 220 FFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRN 279

Query: 364 LAMYINEVKRDKETLRKISEFQSSIENLQVK--LEEFGRPKIDGELKVRSIVNHTKQDRY 421
           +   INE KR  E + KI+++Q+S+ + + +  L+        GE+          Q R 
Sbjct: 280 VTQQINERKRRLENIDKIAQWQASVLDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRV 339

Query: 422 LFLFDKVVIVCKRKGYSYEL---KEIIELLFHKMTD--DPMNNKDVKKWSYGFYLIHLQG 476
            FLFD  +++CK+     ++   K  I++  +++ D  D  ++         F L + + 
Sbjct: 340 FFLFDHQMVLCKKDLIRRDILYYKGRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKET 399

Query: 477 KQGFQFFCKTEDMKRKWMEQFEMAMSNIKPDK 508
           ++   FF K  + K +W+  F      ++ D+
Sbjct: 400 EEIHLFFAKKLEEKIRWLRAFREERKMVQEDE 431



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 18/55 (32%), Positives = 31/55 (56%), Gaps = 2/55 (3%)

Query: 779 IGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833
           I +A A ++      REL+ + GDV+++      D  WW G+ +   GWFP+++V
Sbjct: 10  IVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKD--WWWGQIDDEEGWFPASFV 62


>gi|4504111 growth factor receptor-bound protein 2 isoform 1 [Homo
           sapiens]
          Length = 217

 Score = 91.7 bits (226), Expect = 3e-18
 Identities = 61/236 (25%), Positives = 105/236 (44%), Gaps = 43/236 (18%)

Query: 599 LTFQTGDVLELLRGDPESPWWEGRLVQTRKSGYFPSSSVKPCPVDGRPPISRPPSREIDY 658
           L+F+ GD+L++L  + +  W++  L    K G+ P + ++  P                 
Sbjct: 17  LSFKRGDILKVLNEECDQNWYKAEL--NGKDGFIPKNYIEMKP----------------- 57

Query: 659 TAYPWFAGNMERQQTDNLL-KSHASGTYLIRERPAEAERFAISIKFNDEVKHIKVVEKDN 717
             +PWF G + R + + +L K    G +LIRE  +    F++S+KF ++V+H KV+    
Sbjct: 58  --HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGA 115

Query: 718 WIHITEAKKFDSLLELVEYYQCHSLKESFKQLDTTLKYPYKSRERSASRASSRSPVFTPR 777
             +     KF+SL ELV+Y++  S+  +                    +   R     P+
Sbjct: 116 GKYFLWVVKFNSLNELVDYHRSTSVSRN-------------------QQIFLRDIEQVPQ 156

Query: 778 VIGTAVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYV 833
                 A ++F  ++  EL  R GD + +      D  WWKG  +G+ G FP  YV
Sbjct: 157 QPTYVQALFDFDPQEDGELGFRRGDFIHVMDN--SDPNWWKGACHGQTGMFPRNYV 210



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 21/53 (39%), Positives = 34/53 (64%), Gaps = 1/53 (1%)

Query: 782 AVARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834
           A+A+Y+F A    ELS + GD++++ +    DQ W+K E NG+ G+ P  Y+E
Sbjct: 3   AIAKYDFKATADDELSFKRGDILKVLNE-ECDQNWYKAELNGKDGFIPKNYIE 54


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 72/271 (26%), Positives = 131/271 (48%), Gaps = 27/271 (9%)

Query: 192  DKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLR-----LVLSPADMAAVFINLEDLIKVH 246
            D R    + + +TE  Y  +L  + + YM PL+     ++  P+ +  +F  + +L++ H
Sbjct: 1065 DMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHH 1124

Query: 247  HSFLRAIDVSVMVG------GSTLAKVFLDFKERLL-IYGEYCSHMEHAQNTLNQLLASR 299
              FL  +   +         G+ L + F   K+ L+ IY  Y  +  +A++ +     +R
Sbjct: 1125 EQFLEQVRHCMQTWHAQQKVGALLVQSFS--KDVLVNIYSAYIDNFLNAKDAVRVAKEAR 1182

Query: 300  EDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPERQQLKEAL 358
              F + +E+ +++    K  L DL++ P+QR+ +Y LL+K+LL H+ E  P+   L EA 
Sbjct: 1183 PAFLKFLEQ-SMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQ 1241

Query: 359  EAMQDLAMYIN-------EVKRDKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRS 411
              ++ +A  IN       E +R    L++I      +E+LQ  L  F R ++  E+K   
Sbjct: 1242 RNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG 1301

Query: 412  IVNHTKQDRYLFLFDKVVIVCKRKGYSYELK 442
                 K+DR LFLF  +++    K  S  L+
Sbjct: 1302 ----GKKDRSLFLFTDLIVCTTLKRKSGSLR 1328


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 73/330 (22%), Positives = 143/330 (43%), Gaps = 22/330 (6%)

Query: 200 EIQETEAKYYRTLEDIEKNYMSPLRLV-LSPADMAAVFINLEDLIKVHHSFLRA-IDVSV 257
           E+  TE  Y + L  +++ + + L    + P  +  +F N+  + + H  FL   +   +
Sbjct: 164 ELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223

Query: 258 MVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQ 314
                T   L  +       L +YGEY  + + A   ++        F+  V     +  
Sbjct: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283

Query: 315 DGKFKLQDLLVVPMQRVLKYHLLLKELLSH-SAERPERQQLKEALEAMQDLAMYINEVKR 373
            G   LQ  ++ P+QRV +Y LLLK+ L     + P+R+  + +LE +   A + N   R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343

Query: 374 DKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCK 433
             E + K+ E    +   +  +        +G+++  S  N T QDR+LFLF+ +++ C 
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403

Query: 434 RK----GYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDM 489
            K    G  + ++E       KM    +  +D+ K +     I    K+  +   +TE+ 
Sbjct: 404 PKLRLMGQKFSVRE-------KMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEE 456

Query: 490 KRKWMEQFEMAMSNIKPDKANANHHSFQMY 519
           K++W++  +  +     +K   N  +F+ +
Sbjct: 457 KKEWIQIIQATI-----EKHKQNSETFKAF 481


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 73/330 (22%), Positives = 143/330 (43%), Gaps = 22/330 (6%)

Query: 200 EIQETEAKYYRTLEDIEKNYMSPLRLV-LSPADMAAVFINLEDLIKVHHSFLRA-IDVSV 257
           E+  TE  Y + L  +++ + + L    + P  +  +F N+  + + H  FL   +   +
Sbjct: 164 ELLHTEETYVKRLHLLDQVFCTRLTDAGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRI 223

Query: 258 MVGGST---LAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASREDFRQKVEECTLKVQ 314
                T   L  +       L +YGEY  + + A   ++        F+  V     +  
Sbjct: 224 TEEWDTNPRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEV 283

Query: 315 DGKFKLQDLLVVPMQRVLKYHLLLKELLSH-SAERPERQQLKEALEAMQDLAMYINEVKR 373
            G   LQ  ++ P+QRV +Y LLLK+ L     + P+R+  + +LE +   A + N   R
Sbjct: 284 CGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIR 343

Query: 374 DKETLRKISEFQSSIENLQVKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCK 433
             E + K+ E    +   +  +        +G+++  S  N T QDR+LFLF+ +++ C 
Sbjct: 344 KVEKMHKLLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCV 403

Query: 434 RK----GYSYELKEIIELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQFFCKTEDM 489
            K    G  + ++E       KM    +  +D+ K +     I    K+  +   +TE+ 
Sbjct: 404 PKLRLMGQKFSVRE-------KMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEE 456

Query: 490 KRKWMEQFEMAMSNIKPDKANANHHSFQMY 519
           K++W++  +  +     +K   N  +F+ +
Sbjct: 457 KKEWIQIIQATI-----EKHKQNSETFKAF 481


>gi|55749621 pleckstrin homology domain containing, family G, member
           3 [Homo sapiens]
          Length = 1163

 Score = 84.3 bits (207), Expect = 4e-16
 Identities = 67/248 (27%), Positives = 119/248 (47%), Gaps = 36/248 (14%)

Query: 277 IYGEYCSHMEHAQNTLNQLLASRED---FRQKVEECTLKVQDGKFKLQDLLVVPMQRVLK 333
           IY +YC++  ++   L + +  ++    FR + E     +  G + L+     P+QR+LK
Sbjct: 123 IYTQYCNNYPNSVAALTECMRDKQQAKFFRDRQELLQHSLPLGSYLLK-----PVQRILK 177

Query: 334 YHLLLKELLSHSAERPER-QQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQ 392
           YHLLL+E+  H  E  +  + +++A++ M  +A YIN++KR  E   ++ E QS + N +
Sbjct: 178 YHLLLQEIAKHFDEEEDGFEVVEDAIDTMTCVAWYINDMKRRHEHAVRLQEIQSLLINWK 237

Query: 393 -VKLEEFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYELKEII---ELL 448
              L  +G   ++G  +V  + N    +R  FLFDK +++ K++G  +  K  I    L+
Sbjct: 238 GPDLTTYGELVLEGTFRVHRVRN----ERTFFLFDKTLLITKKRGDHFVYKGNIPCSSLM 293

Query: 449 FHKMTDDPMNNKDVKKWSYGFYLIHLQ-GKQGFQFFCKTEDMKRKWMEQFEMAMSNIKPD 507
             + T D          S  F + H +  KQ +    KT + KR W    +  +      
Sbjct: 294 LIESTRD----------SLCFTVTHYKHSKQQYSIQAKTVEEKRNWTHHIKRLILE---- 339

Query: 508 KANANHHS 515
               NHH+
Sbjct: 340 ----NHHA 343


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 618

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 66/292 (22%), Positives = 138/292 (47%), Gaps = 37/292 (12%)

Query: 170 DIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP--LRLVL 227
           ++++D+ ++     +++   E+ K    + E+  +EA YY++L  +  ++M    +R +L
Sbjct: 158 NLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKIL 217

Query: 228 SPADMAAVFINLEDLIKVHHSFLRAIDVSV---MVGGSTLAKVFLDFKERLLIYGEYCSH 284
            P++   +F N+ D++ V   FL  ++  +   +V       V+    +   +Y  Y S+
Sbjct: 218 HPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSN 277

Query: 285 MEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSH 344
             + + T  QLL  +  FR+ + +  L  +         L++P QR+ +  LL++ +L  
Sbjct: 278 QTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKR 337

Query: 345 SAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLE-------- 396
             ER ER+    AL+A ++L M    VK   E +RK+S  +  I ++Q K+E        
Sbjct: 338 VEERSERE--CTALDAHKELEMV---VKACNEGVRKMSRTEQMI-SIQKKMEFKIKSVPI 391

Query: 397 --------------EFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKR 434
                         +   PK    L+ + + +    + YLFLF+ ++++C++
Sbjct: 392 ISHSRWLLKQGELQQMSGPKTSRTLRTKKLFH----EIYLFLFNDLLVICRQ 439



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)

Query: 774 FTPRVIGTAVAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET--NGRIGWFP 829
           FT R++     +  + + A+   EL+L   D++ I  +   D GW  GE   +   GWFP
Sbjct: 515 FTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKT--DDGWIFGERLHDQERGWFP 572

Query: 830 STYVEE 835
           S+  EE
Sbjct: 573 SSMTEE 578


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 710

 Score = 83.2 bits (204), Expect = 9e-16
 Identities = 66/292 (22%), Positives = 138/292 (47%), Gaps = 37/292 (12%)

Query: 170 DIYEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSP--LRLVL 227
           ++++D+ ++     +++   E+ K    + E+  +EA YY++L  +  ++M    +R +L
Sbjct: 250 NLWQDLPEIRSSGVLEILQPEEIKLQEAMFELVTSEASYYKSLNLLVSHFMENERIRKIL 309

Query: 228 SPADMAAVFINLEDLIKVHHSFLRAIDVSV---MVGGSTLAKVFLDFKERLLIYGEYCSH 284
            P++   +F N+ D++ V   FL  ++  +   +V       V+    +   +Y  Y S+
Sbjct: 310 HPSEAHILFSNVLDVLAVSERFLLELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSN 369

Query: 285 MEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSH 344
             + + T  QLL  +  FR+ + +  L  +         L++P QR+ +  LL++ +L  
Sbjct: 370 QTYQERTYKQLLQEKAAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKR 429

Query: 345 SAERPERQQLKEALEAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLE-------- 396
             ER ER+    AL+A ++L M    VK   E +RK+S  +  I ++Q K+E        
Sbjct: 430 VEERSERE--CTALDAHKELEMV---VKACNEGVRKMSRTEQMI-SIQKKMEFKIKSVPI 483

Query: 397 --------------EFGRPKIDGELKVRSIVNHTKQDRYLFLFDKVVIVCKR 434
                         +   PK    L+ + + +    + YLFLF+ ++++C++
Sbjct: 484 ISHSRWLLKQGELQQMSGPKTSRTLRTKKLFH----EIYLFLFNDLLVICRQ 531



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 21/66 (31%), Positives = 33/66 (50%), Gaps = 6/66 (9%)

Query: 774 FTPRVIGTAVAR--YNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGET--NGRIGWFP 829
           FT R++     +  + + A+   EL+L   D++ I  +   D GW  GE   +   GWFP
Sbjct: 607 FTSRLLDCPQVQCVHPYVAQQPDELTLELADILNILDKT--DDGWIFGERLHDQERGWFP 664

Query: 830 STYVEE 835
           S+  EE
Sbjct: 665 SSMTEE 670


>gi|224586880 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 3 [Homo sapiens]
          Length = 1257

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 85/371 (22%), Positives = 163/371 (43%), Gaps = 42/371 (11%)

Query: 172 YEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPA- 230
           ++ II+  ++ P    M    KRN  +  + E EA+Y + L  +  N++ PLR+  S   
Sbjct: 222 WKTIIQDYIRSPHADSMR---KRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKK 278

Query: 231 ------DMAAVFINLEDLIKVHHSFLRAIDVSVMVGGS-TLAKVFLDFKERLLIYGEYCS 283
                 D++++F+N E ++ +H  F + +   +    +  LA +F      L IY E+  
Sbjct: 279 PPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVR 338

Query: 284 HMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLS 343
           + +++   L     +R DF + ++    K    +  L+  L  PM ++ +Y L L ELL+
Sbjct: 339 NHQYSLQILAHCKQNR-DFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLA 397

Query: 344 HSA-ERPERQQLKEALEAMQDLAMYINEVKRDKETLRK-ISEFQSSIENLQVKLEEFGRP 401
           H+  E  ER  L  A   +++L+  +++   + E +RK ++  +  IE  ++ L+     
Sbjct: 398 HTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTF 457

Query: 402 KIDGEL--------------KVRSIVNHTKQDRYLFLFDKVVIVCKR-KGYSYELKE--I 444
              G L              ++ S+    + +R  FLF K +I+C R  G    L +  +
Sbjct: 458 VRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGV 517

Query: 445 IELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQ----------FFCKTEDMKRKWM 494
           I L+   + ++P + ++  K S G  + HL  K G +              +   K  W 
Sbjct: 518 ISLIDCTLLEEPESTEEEAKGS-GQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWT 576

Query: 495 EQFEMAMSNIK 505
                 + NI+
Sbjct: 577 SDISQCVDNIR 587


>gi|24797099 Ras protein-specific guanine nucleotide-releasing
           factor 1 isoform 1 [Homo sapiens]
          Length = 1273

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 85/371 (22%), Positives = 163/371 (43%), Gaps = 42/371 (11%)

Query: 172 YEDIIKVEVQQPMKMGMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRLVLSPA- 230
           ++ II+  ++ P    M    KRN  +  + E EA+Y + L  +  N++ PLR+  S   
Sbjct: 222 WKTIIQDYIRSPHADSMR---KRNQVVFSMLEAEAEYVQQLHILVNNFLRPLRMAASSKK 278

Query: 231 ------DMAAVFINLEDLIKVHHSFLRAIDVSVMVGGS-TLAKVFLDFKERLLIYGEYCS 283
                 D++++F+N E ++ +H  F + +   +    +  LA +F      L IY E+  
Sbjct: 279 PPITHDDVSSIFLNSETIMFLHQIFYQGLKARISSWPTLVLADLFDILLPMLNIYQEFVR 338

Query: 284 HMEHAQNTLNQLLASREDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLS 343
           + +++   L     +R DF + ++    K    +  L+  L  PM ++ +Y L L ELL+
Sbjct: 339 NHQYSLQILAHCKQNR-DFDKLLKHYEAKPDCEERTLETFLTYPMFQIPRYILTLHELLA 397

Query: 344 HSA-ERPERQQLKEALEAMQDLAMYINEVKRDKETLRK-ISEFQSSIENLQVKLEEFGRP 401
           H+  E  ER  L  A   +++L+  +++   + E +RK ++  +  IE  ++ L+     
Sbjct: 398 HTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMIIEGCEILLDTSQTF 457

Query: 402 KIDGEL--------------KVRSIVNHTKQDRYLFLFDKVVIVCKR-KGYSYELKE--I 444
              G L              ++ S+    + +R  FLF K +I+C R  G    L +  +
Sbjct: 458 VRQGSLIQVPMSEKGKITRGRLGSLSLKKEGERQCFLFSKHLIICTRGSGGKLHLTKNGV 517

Query: 445 IELLFHKMTDDPMNNKDVKKWSYGFYLIHLQGKQGFQ----------FFCKTEDMKRKWM 494
           I L+   + ++P + ++  K S G  + HL  K G +              +   K  W 
Sbjct: 518 ISLIDCTLLEEPESTEEEAKGS-GQDIDHLDFKIGVEPKDSPPFTVILVASSRQEKAAWT 576

Query: 495 EQFEMAMSNIK 505
                 + NI+
Sbjct: 577 SDISQCVDNIR 587


>gi|163644325 MCF.2 cell line derived transforming sequence-like
            isoform a [Homo sapiens]
          Length = 1182

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 118/504 (23%), Positives = 207/504 (41%), Gaps = 84/504 (16%)

Query: 194  RNCCLLEIQETEAKYYRTLEDIEKNYMS----PLRLVLSPADMA----AVFINLEDLIKV 245
            R   + E+ +TE  Y   L  + + Y +    PL   L    +      +F N+E++   
Sbjct: 659  RRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHF 718

Query: 246  HHS-FLRAI----DVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE 300
            H+  FLR +    D   +VG     + FL+  E   IY +YC +   +++   Q   S  
Sbjct: 719  HNRIFLRELENYTDCPELVG-----RCFLERMEDFQIYEKYCQNKPRSESLWRQ--CSDC 771

Query: 301  DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA 360
             F Q   EC  K+ D K  L   L+ P+QR+ KY LLLKE+L +S      + L+EAL +
Sbjct: 772  PFFQ---ECQRKL-DHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSS 827

Query: 361  MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKI-----DGELKVRSIVNH 415
            +  +   +N    D   L  I+ +  ++ +L  KL   G   +      G  KV+ +   
Sbjct: 828  ILGILKAVN----DSMHLIAITGYDGNLGDLG-KLLMQGSFSVWTDHKRGHTKVKELARF 882

Query: 416  TKQDRYLFLFDKVVIVCKRK-----GY----SYELKEIIELLFHKMTDDPMNNKDVKKWS 466
                R+LFL +K V+ CK++     GY    SY  K+ + +    +T++     D KK  
Sbjct: 883  KPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKG--DAKK-- 938

Query: 467  YGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAM-SNIKPDKANANHHSFQM------- 518
              F + +   ++ +     T ++K  W+ +    + S ++  +  + H + +        
Sbjct: 939  --FEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLP 996

Query: 519  ------------YTFDKTTNCKACKMFLRGTFY-----------QGYMCTKCGVGAHKEC 555
                            K    K   + L G              +G+  T   + A ++ 
Sbjct: 997  APTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDD 1056

Query: 556  LEVIPPCKFTSPADLDASGAGPGPKMVAMQNYH--GNPAPPGKPVLTFQTGDVLELLRGD 613
                   +  + +D +  G G GPK +    Y    +    G   L  ++GDV+EL++  
Sbjct: 1057 GGWSSAEEQINSSDAEEDG-GLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEG 1115

Query: 614  PESPWWEGRLVQTRKSGYFPSSSV 637
             E  W+  R   T K G+ P+SS+
Sbjct: 1116 DEGLWYV-RDPTTGKEGWVPASSL 1138



 Score = 30.8 bits (68), Expect = 5.5
 Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 4/38 (10%)

Query: 796  LSLREGDVVRIYSRIGGDQGWW--KGETNGRIGWFPST 831
            L +R GDVV +     GD+G W  +  T G+ GW P++
Sbjct: 1101 LRVRSGDVVELVQE--GDEGLWYVRDPTTGKEGWVPAS 1136


>gi|163644323 MCF.2 cell line derived transforming sequence-like
            isoform b [Homo sapiens]
          Length = 1129

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 118/504 (23%), Positives = 207/504 (41%), Gaps = 84/504 (16%)

Query: 194  RNCCLLEIQETEAKYYRTLEDIEKNYMS----PLRLVLSPADMA----AVFINLEDLIKV 245
            R   + E+ +TE  Y   L  + + Y +    PL   L    +      +F N+E++   
Sbjct: 606  RRHVMSELLDTERAYVEELLCVLEGYAAEMDNPLMAHLLSTGLHNKKDVLFGNMEEIYHF 665

Query: 246  HHS-FLRAI----DVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLASRE 300
            H+  FLR +    D   +VG     + FL+  E   IY +YC +   +++   Q   S  
Sbjct: 666  HNRIFLRELENYTDCPELVG-----RCFLERMEDFQIYEKYCQNKPRSESLWRQ--CSDC 718

Query: 301  DFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEALEA 360
             F Q   EC  K+ D K  L   L+ P+QR+ KY LLLKE+L +S      + L+EAL +
Sbjct: 719  PFFQ---ECQRKL-DHKLSLDSYLLKPVQRITKYQLLLKEMLKYSRNCEGAEDLQEALSS 774

Query: 361  MQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKI-----DGELKVRSIVNH 415
            +  +   +N    D   L  I+ +  ++ +L  KL   G   +      G  KV+ +   
Sbjct: 775  ILGILKAVN----DSMHLIAITGYDGNLGDLG-KLLMQGSFSVWTDHKRGHTKVKELARF 829

Query: 416  TKQDRYLFLFDKVVIVCKRK-----GY----SYELKEIIELLFHKMTDDPMNNKDVKKWS 466
                R+LFL +K V+ CK++     GY    SY  K+ + +    +T++     D KK  
Sbjct: 830  KPMQRHLFLHEKAVLFCKKREENGEGYEKAPSYSYKQSLNMAAVGITENVKG--DAKK-- 885

Query: 467  YGFYLIHLQGKQGFQFFCKTEDMKRKWMEQFEMAM-SNIKPDKANANHHSFQM------- 518
              F + +   ++ +     T ++K  W+ +    + S ++  +  + H + +        
Sbjct: 886  --FEIWYNAREEVYIVQAPTPEIKAAWVNEIRKVLTSQLQACREASQHRALEQSQSLPLP 943

Query: 519  ------------YTFDKTTNCKACKMFLRGTFY-----------QGYMCTKCGVGAHKEC 555
                            K    K   + L G              +G+  T   + A ++ 
Sbjct: 944  APTSTSPSRGNSRNIKKLEERKTDPLSLEGYVSSAPLTKPPEKGKGWSKTSHSLEAPEDD 1003

Query: 556  LEVIPPCKFTSPADLDASGAGPGPKMVAMQNYH--GNPAPPGKPVLTFQTGDVLELLRGD 613
                   +  + +D +  G G GPK +    Y    +    G   L  ++GDV+EL++  
Sbjct: 1004 GGWSSAEEQINSSDAEEDG-GLGPKKLVPGKYTVVADHEKGGPDALRVRSGDVVELVQEG 1062

Query: 614  PESPWWEGRLVQTRKSGYFPSSSV 637
             E  W+  R   T K G+ P+SS+
Sbjct: 1063 DEGLWYV-RDPTTGKEGWVPASSL 1085



 Score = 30.8 bits (68), Expect = 5.5
 Identities = 15/38 (39%), Positives = 22/38 (57%), Gaps = 4/38 (10%)

Query: 796  LSLREGDVVRIYSRIGGDQGWW--KGETNGRIGWFPST 831
            L +R GDVV +     GD+G W  +  T G+ GW P++
Sbjct: 1048 LRVRSGDVVELVQE--GDEGLWYVRDPTTGKEGWVPAS 1083


>gi|153791628 MCF.2 cell line derived transforming sequence isoform
           a [Homo sapiens]
          Length = 985

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 71/273 (26%), Positives = 120/273 (43%), Gaps = 36/273 (13%)

Query: 187 GMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMS----PLRLVLSPADMA----AVFIN 238
           G + D  +N  L E+ +TE  Y R L  +   Y +    P    L P  +      +F N
Sbjct: 549 GNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGN 608

Query: 239 LEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLAS 298
           + ++ + H+    +   +       +   FL+ K+   +Y +YC +   ++    +   S
Sbjct: 609 MAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKY--S 666

Query: 299 REDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEAL 358
              F Q   EC  K++  + +L   L+ P+QR+ KY LLLKELL +S +      LK+AL
Sbjct: 667 ECAFFQ---ECQRKLKH-RLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKAL 722

Query: 359 EAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKID-----------GEL 407
           +AM DL   +N+           S  Q +I      L E G+  +            G  
Sbjct: 723 DAMLDLLKSVND-----------SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGAT 771

Query: 408 KVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYE 440
           K++ +       R+LFL++K ++ CKR+  S E
Sbjct: 772 KMKDLARFKPMQRHLFLYEKAIVFCKRRVESGE 804


>gi|153791325 MCF.2 cell line derived transforming sequence isoform
           b [Homo sapiens]
          Length = 925

 Score = 77.8 bits (190), Expect = 4e-14
 Identities = 71/273 (26%), Positives = 120/273 (43%), Gaps = 36/273 (13%)

Query: 187 GMTEDDKRNCCLLEIQETEAKYYRTLEDIEKNYMS----PLRLVLSPADMA----AVFIN 238
           G + D  +N  L E+ +TE  Y R L  +   Y +    P    L P  +      +F N
Sbjct: 489 GNSLDVLKNHVLNELIQTERVYVRELYTVLLGYRAEMDNPEMFDLMPPLLRNKKDILFGN 548

Query: 239 LEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLLIYGEYCSHMEHAQNTLNQLLAS 298
           + ++ + H+    +   +       +   FL+ K+   +Y +YC +   ++    +   S
Sbjct: 549 MAEIYEFHNDIFLSSLENCAHAPERVGPCFLERKDDFQMYAKYCQNKPRSETIWRKY--S 606

Query: 299 REDFRQKVEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAERPERQQLKEAL 358
              F Q   EC  K++  + +L   L+ P+QR+ KY LLLKELL +S +      LK+AL
Sbjct: 607 ECAFFQ---ECQRKLKH-RLRLDSYLLKPVQRITKYQLLLKELLKYSKDCEGSALLKKAL 662

Query: 359 EAMQDLAMYINEVKRDKETLRKISEFQSSIENLQVKLEEFGRPKID-----------GEL 407
           +AM DL   +N+           S  Q +I      L E G+  +            G  
Sbjct: 663 DAMLDLLKSVND-----------SMHQIAINGYIGNLNELGKMIMQGGFSVWIGHKKGAT 711

Query: 408 KVRSIVNHTKQDRYLFLFDKVVIVCKRKGYSYE 440
           K++ +       R+LFL++K ++ CKR+  S E
Sbjct: 712 KMKDLARFKPMQRHLFLYEKAIVFCKRRVESGE 744


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 53/205 (25%), Positives = 99/205 (48%), Gaps = 8/205 (3%)

Query: 193  KRNCCLLEIQETEAKYYRTLEDIEKNYMSPLRL--VLSPADMAAVFINLEDLIKVHHSFL 250
            KR   + E+  TE  Y   L+ + + +  PL    +L+  ++A +F+N ++LI  +   L
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296

Query: 251  RAIDVSVMVGGSTL-AKVFLDFKERLLI----YGEYCSHMEHAQNTLNQLLASREDFRQK 305
            +A+ V   + G  +  K+  D     L     Y  +CS   +    + Q      DF++ 
Sbjct: 1297 KALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEF 1356

Query: 306  VEECTLKVQDGKFKLQDLLVVPMQRVLKYHLLLKELLSHSAE-RPERQQLKEALEAMQDL 364
            V+   +  +     L   ++ PMQRV +Y L++K +L ++ E  P+   LK ALE  ++L
Sbjct: 1357 VKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEEL 1416

Query: 365  AMYINEVKRDKETLRKISEFQSSIE 389
               +NE  R+KE   ++   Q+ ++
Sbjct: 1417 CSQVNEGVREKENSDRLEWIQAHVQ 1441



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 19/52 (36%), Positives = 34/52 (65%), Gaps = 2/52 (3%)

Query: 783  VARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834
            +  Y++ A++  EL+  +G ++ + ++   D  WWKGE NG++G FPS YV+
Sbjct: 1161 IGMYDYTAQNDDELAFNKGQIINVLNK--EDPDWWKGEVNGQVGLFPSNYVK 1210



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 25/76 (32%), Positives = 37/76 (48%), Gaps = 4/76 (5%)

Query: 759  SRERSASRASSRSPVFTPRVIGTA-VARYNFAARDMRELSLREGDVVRIYSRIGGDQGWW 817
            S E  AS     SP   P V G   +A Y + + +  +L+ ++GDV+ +  +   D  WW
Sbjct: 983  SSESPASLKRVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTKK---DGDWW 1039

Query: 818  KGETNGRIGWFPSTYV 833
             G    + G FPS YV
Sbjct: 1040 TGTVGDKAGVFPSNYV 1055



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 20/57 (35%), Positives = 31/57 (54%), Gaps = 5/57 (8%)

Query: 784 ARYNFAARDMRELSLREGDVVRIYSRI-----GGDQGWWKGETNGRIGWFPSTYVEE 835
           A Y F +R   E++++ GD+V +          G+ GW  GE  G+ GWFP+ Y E+
Sbjct: 747 ALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 29/83 (34%), Positives = 42/83 (50%), Gaps = 11/83 (13%)

Query: 760 RERSA-----SRASSRSPVFTP--RVIGT-AVARYNFAARDMRELSLREGDVVRIYSRIG 811
           R+RSA     +  SS SPV     +V G  A A Y + A+    L+  + DV+ +  +  
Sbjct: 888 RQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQ-- 945

Query: 812 GDQGWWKGETNGRIGWFPSTYVE 834
               WW GE  G+ GWFP +YV+
Sbjct: 946 -QDMWWFGEVQGQKGWFPKSYVK 967



 Score = 38.5 bits (88), Expect = 0.026
 Identities = 19/53 (35%), Positives = 29/53 (54%), Gaps = 7/53 (13%)

Query: 787  NFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGR-----IGWFPSTYVE 834
            ++ A    +L+L  G ++ I  +  G  GWW+GE   R     IGWFP+ YV+
Sbjct: 1084 SYTATGPEQLTLAPGQLILIRKKNPG--GWWEGELQARGKKRQIGWFPANYVK 1134


>gi|39930351 dynamin binding protein [Homo sapiens]
          Length = 1577

 Score = 76.6 bits (187), Expect = 9e-14
 Identities = 81/293 (27%), Positives = 126/293 (43%), Gaps = 60/293 (20%)

Query: 133 ETTENDDDVYRS--------LEELADEHDLGEDIYDCVPCEDGGDDIYEDIIKVEVQQPM 184
           E  E D D+Y          LEE  DE    E + D   CE   + +      +E+QQ  
Sbjct: 699 EEMERDLDMYSRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESL-----NMELQQLR 753

Query: 185 KMGMTED----------------------DKRNCCLLEIQETEAKYYRTLEDIEKNYMSP 222
           +M +                         +KR   + E+ +TE  Y R LE   +  M P
Sbjct: 754 EMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVP 813

Query: 223 LRLVLSP-ADMAAVFINLEDLIKVHHSFLRAIDVSVMVGGSTLAKVFLDFKERLL-IYGE 280
           ++    P  D   +F N++ +IKV    L A+++S  VG      VFL  ++ L   Y  
Sbjct: 814 MQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEISDAVG-----PVFLGHRDELEGTYKI 868

Query: 281 YCSHMEHA----------QNTLNQLLASREDFRQKVEE--CTLKVQDGKFKLQDLLVVPM 328
           YC + + A          +     L  S  D +    E  CT  +  G F     L+ P+
Sbjct: 869 YCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSF-----LIKPV 923

Query: 329 QRVLKYHLLLKELLSHSAE-RPERQQLKEALEAMQDLAMYINEVKRDKETLRK 380
           QRV++Y LLL ELL+ + E  P++  L  A+ A++++ + INE KR K+ + K
Sbjct: 924 QRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKDLVLK 976



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 29/78 (37%), Positives = 43/78 (55%), Gaps = 7/78 (8%)

Query: 758 KSRERSASRASSRSPVFTPRVIGTAVARYNFAARDMRELSLREGDVVRIYSRIG-GDQGW 816
           +SR+  +  A  + P ++   +G A A    +A+   EL  REGDV+ I   IG  + GW
Sbjct: 129 QSRQWHSQSALFQIPEYS---MGQARALMGLSAQLDEELDFREGDVITI---IGVPEPGW 182

Query: 817 WKGETNGRIGWFPSTYVE 834
           ++GE  GR G FP  +VE
Sbjct: 183 FEGELEGRRGIFPEGFVE 200



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 19/54 (35%), Positives = 30/54 (55%), Gaps = 2/54 (3%)

Query: 784  ARYNFAARDMRELSLREGDVVRI--YSRIGGDQGWWKGETNGRIGWFPSTYVEE 835
            A Y F AR+  ELS+     ++I  +  + G+  WW  E NG+ G+ PS Y+ +
Sbjct: 1520 AVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRK 1573



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 2/52 (3%)

Query: 783 VARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834
           VA Y F A +  EL    GD +RI + +  + GW +G   GR G FP  +V+
Sbjct: 249 VALYRFQALEPNELDFEVGDKIRILATL--EDGWLEGSLKGRTGIFPYRFVK 298



 Score = 30.4 bits (67), Expect = 7.1
 Identities = 16/51 (31%), Positives = 27/51 (52%), Gaps = 2/51 (3%)

Query: 784 ARYNFAARDMRELSLREGDVVRIYSRIGGDQGWWKGETNGRIGWFPSTYVE 834
           A ++F      EL L  GD++ + + +  D+ W  G+     G FPS++VE
Sbjct: 9   AIFDFCPSVSEELPLFVGDIIEVLAVV--DEFWLLGKKEDVTGQFPSSFVE 57


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.137    0.418 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,133,768
Number of Sequences: 37866
Number of extensions: 1606892
Number of successful extensions: 6427
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 279
Number of HSP's successfully gapped in prelim test: 299
Number of HSP's that attempted gapping in prelim test: 5285
Number of HSP's gapped (non-prelim): 1131
length of query: 839
length of database: 18,247,518
effective HSP length: 111
effective length of query: 728
effective length of database: 14,044,392
effective search space: 10224317376
effective search space used: 10224317376
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.