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Search of human proteins with 40549435
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40549435 transmembrane phosphatase with tensin homology
isoform gamma [Homo sapiens]
(513 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40549435 transmembrane phosphatase with tensin homology isofo... 1028 0.0
gi|40549433 transmembrane phosphatase with tensin homology isofo... 1016 0.0
gi|109689707 transmembrane phosphatase with tensin homology isof... 1009 0.0
gi|213972591 TPTE and PTEN homologous inositol lipid phosphatase... 837 0.0
gi|213972589 TPTE and PTEN homologous inositol lipid phosphatase... 714 0.0
gi|213972593 TPTE and PTEN homologous inositol lipid phosphatase... 620 e-178
gi|73765544 phosphatase and tensin homolog [Homo sapiens] 206 5e-53
gi|66529407 tensin [Homo sapiens] 124 2e-28
gi|65288071 tensin 3 [Homo sapiens] 122 1e-27
gi|157384971 cyclin G associated kinase [Homo sapiens] 119 7e-27
gi|38787970 tensin like C1 domain containing phosphatase isoform... 108 2e-23
gi|38787957 tensin like C1 domain containing phosphatase isoform... 108 2e-23
gi|38787941 tensin like C1 domain containing phosphatase isoform... 108 2e-23
gi|239756009 PREDICTED: similar to transmembrane phosphoinositid... 103 3e-22
gi|7662146 DnaJ (Hsp40) homolog, subfamily C, member 6 [Homo sap... 97 3e-20
gi|91992155 hydrogen voltage-gated channel 1 [Homo sapiens] 73 5e-13
gi|91992153 hydrogen voltage-gated channel 1 [Homo sapiens] 73 5e-13
gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo... 46 9e-05
gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens] 45 2e-04
gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapi... 43 6e-04
gi|205277447 dual specificity phosphatase 11 [Homo sapiens] 42 0.002
gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo sa... 41 0.002
gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo sa... 41 0.002
gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H... 41 0.003
gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H... 41 0.003
gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I... 41 0.003
gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I... 41 0.003
gi|126362955 sodium channel, voltage-gated, type III, alpha isof... 39 0.009
gi|126362947 sodium channel, voltage-gated, type III, alpha isof... 39 0.009
gi|126362949 sodium channel, voltage-gated, type III, alpha isof... 39 0.009
>gi|40549435 transmembrane phosphatase with tensin homology isoform
gamma [Homo sapiens]
Length = 513
Score = 1028 bits (2658), Expect = 0.0
Identities = 513/513 (100%), Positives = 513/513 (100%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESSKIKKIVHSIVSSFAFGLFG 60
MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESSKIKKIVHSIVSSFAFGLFG
Sbjct: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESSKIKKIVHSIVSSFAFGLFG 60
Query: 61 VFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLF 120
VFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLF
Sbjct: 61 VFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLF 120
Query: 121 NILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKL 180
NILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKL
Sbjct: 121 NILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKL 180
Query: 181 IRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNH 240
IRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNH
Sbjct: 181 IRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNH 240
Query: 241 YRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHC 300
YRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHC
Sbjct: 241 YRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHC 300
Query: 301 KGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFA 360
KGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFA
Sbjct: 301 KGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFA 360
Query: 361 QVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT 420
QVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT
Sbjct: 361 QVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT 420
Query: 421 TDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNL 480
TDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNL
Sbjct: 421 TDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNL 480
Query: 481 HKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD 513
HKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD
Sbjct: 481 HKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD 513
>gi|40549433 transmembrane phosphatase with tensin homology isoform
beta [Homo sapiens]
Length = 533
Score = 1016 bits (2627), Expect = 0.0
Identities = 513/533 (96%), Positives = 513/533 (96%), Gaps = 20/533 (3%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES-------------------- 40
MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES
Sbjct: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESVLARLSKFEVEDAENVASYD 60
Query: 41 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 100
SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL
Sbjct: 61 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 120
Query: 101 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 160
MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR
Sbjct: 121 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 180
Query: 161 LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 220
LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS
Sbjct: 181 LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 240
Query: 221 FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF 280
FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF
Sbjct: 241 FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF 300
Query: 281 TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH 340
TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH
Sbjct: 301 TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH 360
Query: 341 SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME 400
SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME
Sbjct: 361 SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME 420
Query: 401 KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL 460
KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL
Sbjct: 421 KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL 480
Query: 461 HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD 513
HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD
Sbjct: 481 HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEKMTSSDVVAGSD 533
>gi|109689707 transmembrane phosphatase with tensin homology isoform
alpha [Homo sapiens]
Length = 551
Score = 1009 bits (2609), Expect = 0.0
Identities = 513/551 (93%), Positives = 513/551 (93%), Gaps = 38/551 (6%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES-------------------- 40
MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES
Sbjct: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESPHTSEFKGAARVSPISESVL 60
Query: 41 ------------------SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKL 82
SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKL
Sbjct: 61 ARLSKFEVEDAENVASYDSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKL 120
Query: 83 YIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFD 142
YIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFD
Sbjct: 121 YIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFD 180
Query: 143 IKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLT 202
IKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLT
Sbjct: 181 IKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLT 240
Query: 203 YVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV 262
YVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV
Sbjct: 241 YVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV 300
Query: 263 RIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICS 322
RIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICS
Sbjct: 301 RIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICS 360
Query: 323 TAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFI 382
TAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFI
Sbjct: 361 TAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFI 420
Query: 383 IYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQF 442
IYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQF
Sbjct: 421 IYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQF 480
Query: 443 FYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK 502
FYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK
Sbjct: 481 FYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK 540
Query: 503 MTSSDVVAGSD 513
MTSSDVVAGSD
Sbjct: 541 MTSSDVVAGSD 551
>gi|213972591 TPTE and PTEN homologous inositol lipid phosphatase
isoform gamma [Homo sapiens]
Length = 522
Score = 837 bits (2162), Expect = 0.0
Identities = 424/522 (81%), Positives = 451/522 (86%), Gaps = 20/522 (3%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES-------------------- 40
MNESP + G E +SP TSEFKGA +P +S
Sbjct: 1 MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKSMLERLSKFEVEDAENVASYD 60
Query: 41 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 100
SKIKKIVHSIVSSFAFG+FGVFLVLLDVTL+LADLIFTDSKLYIPLEYRSISLAI LFFL
Sbjct: 61 SKIKKIVHSIVSSFAFGIFGVFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFL 120
Query: 101 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 160
MDVLLRVFVE RQQYFSDLFNILDTAIIVI LLVDV+YIFFDIKLLRNIPRWTHL+RLLR
Sbjct: 121 MDVLLRVFVEGRQQYFSDLFNILDTAIIVIPLLVDVIYIFFDIKLLRNIPRWTHLVRLLR 180
Query: 161 LIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 220
LIIL+RIFHL HQKRQLEKL+RR VSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS
Sbjct: 181 LIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQS 240
Query: 221 FYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF 280
FYRNPI+EVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRV RIMIDDHNVPTLH+MVVF
Sbjct: 241 FYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVF 300
Query: 281 TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTH 340
TKEVNEWMAQDLENIVAIHCKGG RTGTMVCA LIASEI TA+ESLYYFGERRT+KTH
Sbjct: 301 TKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTH 360
Query: 341 SEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEME 400
S KFQGVETPSQ RYV YFAQVKHLYNWNLPPRRILFIK FIIYSI V DLK+Q+ ME
Sbjct: 361 SNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVME 420
Query: 401 KKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWL 460
KKVVFS+ SLG CS+L +I TDKILI+V+DG PLYDDVKVQFF SNLP YYDNC F+FW
Sbjct: 421 KKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWF 480
Query: 461 HTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEILFGEK 502
+TSFI+NNRL LP+NELDN HKQKA +IYP +FAVEILFGEK
Sbjct: 481 NTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEILFGEK 522
>gi|213972589 TPTE and PTEN homologous inositol lipid phosphatase
isoform alpha [Homo sapiens]
Length = 445
Score = 714 bits (1844), Expect = 0.0
Identities = 369/502 (73%), Positives = 396/502 (78%), Gaps = 57/502 (11%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESSKIKKIVHSIVSSFAFGLFG 60
MNESP + G E +SP TSEFKGA ++VS + +FG
Sbjct: 1 MNESPQTNEFKGTTEEAPAKESPHTSEFKGA-----------------ALVSPISKRIFG 43
Query: 61 VFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYFSDLF 120
VFLVLLDVTL+LADLIFTDSKLYIPLEYRSISLAI LFFLMDVLLRVFVE
Sbjct: 44 VFLVLLDVTLLLADLIFTDSKLYIPLEYRSISLAIGLFFLMDVLLRVFVE---------- 93
Query: 121 NILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKL 180
WTHL+RLLRLIIL+RIFHL HQKRQLEKL
Sbjct: 94 ------------------------------GWTHLVRLLRLIILIRIFHLLHQKRQLEKL 123
Query: 181 IRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNH 240
+RR VSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPI+EVVRFLDKKHRNH
Sbjct: 124 MRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNH 183
Query: 241 YRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHC 300
YRVYNLCSERAYDPKHFHNRV RIMIDDHNVPTLH+MVVFTKEVNEWMAQDLENIVAIHC
Sbjct: 184 YRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHC 243
Query: 301 KGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFA 360
KGG RTGTMVCA LIASEI TA+ESLYYFGERRT+KTHS KFQGVETPSQ RYV YFA
Sbjct: 244 KGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFA 303
Query: 361 QVKHLYNWNLPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT 420
QVKHLYNWNLPPRRILFIK FIIYSI V DLK+Q+ MEKKVVFS+ SLG CS+L +I
Sbjct: 304 QVKHLYNWNLPPRRILFIKRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIE 363
Query: 421 TDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNL 480
TDKILI+V+DG PLYDDVKVQFF SNLP YYDNC F+FW +TSFI+NNRL LP+NELDN
Sbjct: 364 TDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNP 423
Query: 481 HKQKARRIYPSDFAVEILFGEK 502
HKQKA +IYP +FAVEILFGEK
Sbjct: 424 HKQKAWKIYPPEFAVEILFGEK 445
>gi|213972593 TPTE and PTEN homologous inositol lipid phosphatase
isoform delta [Homo sapiens]
Length = 411
Score = 620 bits (1600), Expect = e-178
Identities = 303/364 (83%), Positives = 327/364 (89%), Gaps = 2/364 (0%)
Query: 141 FDIKLLRNIP--RWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFD 198
F+++ N+ WTHL+RLLRLIIL+RIFHL HQKRQLEKL+RR VSENKRRYTRDGFD
Sbjct: 48 FEVEDAENVASYEWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFD 107
Query: 199 LDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFH 258
LDLTYVTERIIAMSFPSSGRQSFYRNPI+EVVRFLDKKHRNHYRVYNLCSERAYDPKHFH
Sbjct: 108 LDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFH 167
Query: 259 NRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIAS 318
NRV RIMIDDHNVPTLH+MVVFTKEVNEWMAQDLENIVAIHCKGG RTGTMVCA LIAS
Sbjct: 168 NRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIAS 227
Query: 319 EICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRILFI 378
EI TA+ESLYYFGERRT+KTHS KFQGVETPSQ RYV YFAQVKHLYNWNLPPRRILFI
Sbjct: 228 EIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHLYNWNLPPRRILFI 287
Query: 379 KHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTDKILIDVFDGLPLYDDV 438
K FIIYSI V DLK+Q+ MEKKVVFS+ SLG CS+L +I TDKILI+V+DG PLYDDV
Sbjct: 288 KRFIIYSIRGDVCDLKVQVVMEKKVVFSSTSLGNCSILHDIETDKILINVYDGPPLYDDV 347
Query: 439 KVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYPSDFAVEIL 498
KVQFF SNLP YYDNC F+FW +TSFI+NNRL LP+NELDN HKQKA +IYP +FAVEIL
Sbjct: 348 KVQFFSSNLPKYYDNCPFFFWFNTSFIQNNRLCLPRNELDNPHKQKAWKIYPPEFAVEIL 407
Query: 499 FGEK 502
FGEK
Sbjct: 408 FGEK 411
Score = 41.6 bits (96), Expect = 0.002
Identities = 18/21 (85%), Positives = 20/21 (95%)
Query: 20 NDSPQTSEFKGATEEAPAKES 40
N+SPQT+EFKG TEEAPAKES
Sbjct: 2 NESPQTNEFKGTTEEAPAKES 22
Score = 37.4 bits (85), Expect = 0.033
Identities = 18/40 (45%), Positives = 22/40 (55%)
Query: 1 MNESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKES 40
MNESP + G E +SP TSEFKGA +P +S
Sbjct: 1 MNESPQTNEFKGTTEEAPAKESPHTSEFKGAALVSPISKS 40
>gi|73765544 phosphatase and tensin homolog [Homo sapiens]
Length = 403
Score = 206 bits (523), Expect = 5e-53
Identities = 126/360 (35%), Positives = 194/360 (53%), Gaps = 56/360 (15%)
Query: 180 LIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRN 239
+I+ VS NKRRY DGFDLDLTY+ IIAM FP+ + YRN I +VVRFLD KH+N
Sbjct: 4 IIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKN 63
Query: 240 HYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIH 299
HY++YNLC+ER YD F+ RV + +DHN P L + F +++++W+++D ++ AIH
Sbjct: 64 HYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIH 123
Query: 300 CKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRT-DKTHSEKFQGVETPSQKRYVAY 358
CK G RTG M+CA+L+ A+E+L ++GE RT DK +GV PSQ+RYV Y
Sbjct: 124 CKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDK------KGVTIPSQRRYVYY 177
Query: 359 FAQVKHLYNWNLPPRRILFIKHFIIY-SIPRY----VRDLKIQIEMEKKVVFSTISLGKC 413
++ +L +L R + + H +++ +IP + + +++ K+ S +
Sbjct: 178 YS---YLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTR- 233
Query: 414 SVLDNITTDKILIDVF-DGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFI------- 465
DK + F LP+ D+KV+FF+ + F+FW++T FI
Sbjct: 234 ------REDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETS 287
Query: 466 ----------------------ENNRLY----LPKNELDNLHKQKARRIYPSDFAVEILF 499
+N++ Y L KN+LD +K KA R + +F V++ F
Sbjct: 288 EKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYF 347
>gi|66529407 tensin [Homo sapiens]
Length = 1735
Score = 124 bits (311), Expect = 2e-28
Identities = 90/313 (28%), Positives = 152/313 (48%), Gaps = 17/313 (5%)
Query: 191 RYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSER 250
R D +LDL YVTERIIA+SFPS+ + +R+ ++EV + L KH +Y ++NL SER
Sbjct: 5 RTMEDSCELDLVYVTERIIAVSFPSTANEENFRSNLREVAQMLKSKHGGNYLLFNL-SER 63
Query: 251 AYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTM 310
D H +V+ D + P L ++ K ++ W+ D N+V +H KG R G +
Sbjct: 64 RPDITKLHAKVLEFGWPDLHTPALEKICSICKAMDTWLNADPHNVVVLHNKGNRGRIGVV 123
Query: 311 VCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWN 369
+ A++ S I ++A ++L F +R + +K + PSQ+RYV YF+ + N
Sbjct: 124 IAAYMHYSNISASADQALDRFAMKR---FYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMN 180
Query: 370 LPPRRILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNITTD---KILI 426
P LF+ H I++ IP + + + ++ + S + NI D + I
Sbjct: 181 NKP---LFLHHVIMHGIPNFESKGGCRPFLR---IYQAMQPVYTSGIYNIPGDSQTSVCI 234
Query: 427 DVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKAR 486
+ GL L D+ ++ ++ + + F HT I + + K +LD+ K
Sbjct: 235 TIEPGLLLKGDILLKCYHKKFRSPARDVIFRVQFHTCAIHDLGVVFGKEDLDDAFKDDR- 293
Query: 487 RIYPSDFAVEILF 499
+P VE +F
Sbjct: 294 --FPEYGKVEFVF 304
>gi|65288071 tensin 3 [Homo sapiens]
Length = 1445
Score = 122 bits (305), Expect = 1e-27
Identities = 88/323 (27%), Positives = 154/323 (47%), Gaps = 26/323 (8%)
Query: 195 DGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDP 254
+G LDLTY+TERIIA+SFP+ + Y + ++EV R L KH ++Y V NL SE+ YD
Sbjct: 3 EGHGLDLTYITERIIAVSFPAGCSEESYLHNLQEVTRMLKSKHGDNYLVLNL-SEKRYDL 61
Query: 255 KHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAF 314
+ +++ + + + P L +M K W+ +L+++V IHC+GG R G ++ ++
Sbjct: 62 TKLNPKIMDVGWPELHAPPLDKMCTICKAQESWLNSNLQHVVVIHCRGGKGRIGVVISSY 121
Query: 315 LIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWNLPPR 373
+ + + ++A ++L F + K + +K + PSQKRYV + + + N P
Sbjct: 122 MHFTNVSASADQALDRFAMK---KFYDDKVSALMQPSQKRYVQFLSGLLSGSVKMNASP- 177
Query: 374 RILFIKHFIIYSIPRYVRD------LKIQIEMEKKVVFSTISLGKCSVLDNITTDKILID 427
LF+ I++ P + LK+ M+ ++G +I I
Sbjct: 178 --LFLHFVILHGTPNFDTGGVCRPFLKLYQAMQPVYTSGIYNVGP------ENPSRICIV 229
Query: 428 VFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARR 487
+ L DV V+ ++ + + F HT ++ L K +LDN K
Sbjct: 230 IEPAQLLKGDVMVKCYHKKYRSATRDVIFRLQFHTGAVQGYGLVFGKEDLDNASKDDR-- 287
Query: 488 IYPSDFAVEILFG---EKMTSSD 507
+P VE++F EK+ S+
Sbjct: 288 -FPDYGKVELVFSATPEKIQGSE 309
>gi|157384971 cyclin G associated kinase [Homo sapiens]
Length = 1311
Score = 119 bits (298), Expect = 7e-27
Identities = 63/165 (38%), Positives = 89/165 (53%), Gaps = 9/165 (5%)
Query: 198 DLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHF 257
DLD++Y+T RI MSFP+ G +S +N I++V FLD KH HY VYNL S R Y P F
Sbjct: 407 DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRF 465
Query: 258 HNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIA 317
HNRV P LH + + ++ W+ QD +N+ +HC G + VC+FL
Sbjct: 466 HNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF 525
Query: 318 SEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQV 362
+ STA+ ++Y F +R G+ PS KRY+ Y +
Sbjct: 526 CRLFSTAEAAVYMFSMKRCP-------PGI-WPSHKRYIEYMCDM 562
>gi|38787970 tensin like C1 domain containing phosphatase isoform 3
[Homo sapiens]
Length = 1285
Score = 108 bits (269), Expect = 2e-23
Identities = 86/322 (26%), Positives = 157/322 (48%), Gaps = 24/322 (7%)
Query: 197 FDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKH 256
+DLDLTYVTERI+A +FP+ + +R ++E+ L KHR+ Y ++NL SE+ +D
Sbjct: 5 WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTR 63
Query: 257 FHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLI 316
+ +V + + P L ++ K + W++ D +++V ++CKG + G +V A++
Sbjct: 64 LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMH 123
Query: 317 ASEICSTAKESLYYFGERR--TDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWNLPPR 373
S+I + A ++L R+ DK +E PSQ+RY++YF+ + N P
Sbjct: 124 YSKISAGADQALATLTMRKFCEDKVATEL-----QPSQRRYISYFSGLLSGSIRMNSSP- 177
Query: 374 RILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT---TDKILIDVFD 430
LF+ + +I +P + Q ++ ++ ++ L S + +I ++ I +
Sbjct: 178 --LFLHYVLIPMLPAFEPGTGFQPFLK---IYQSMQLVYTSGVYHIAGPGPQQLCISLEP 232
Query: 431 GLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYP 490
L L DV V ++ F HT I +L PK++LD + +P
Sbjct: 233 ALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDER---FP 289
Query: 491 SDFAVEILFGEKMTSSDVVAGS 512
+VE +F +S + + GS
Sbjct: 290 FQASVEFVFS---SSPEKIKGS 308
>gi|38787957 tensin like C1 domain containing phosphatase isoform 2
[Homo sapiens]
Length = 1409
Score = 108 bits (269), Expect = 2e-23
Identities = 86/322 (26%), Positives = 157/322 (48%), Gaps = 24/322 (7%)
Query: 197 FDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKH 256
+DLDLTYVTERI+A +FP+ + +R ++E+ L KHR+ Y ++NL SE+ +D
Sbjct: 129 WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTR 187
Query: 257 FHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLI 316
+ +V + + P L ++ K + W++ D +++V ++CKG + G +V A++
Sbjct: 188 LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMH 247
Query: 317 ASEICSTAKESLYYFGERR--TDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWNLPPR 373
S+I + A ++L R+ DK +E PSQ+RY++YF+ + N P
Sbjct: 248 YSKISAGADQALATLTMRKFCEDKVATEL-----QPSQRRYISYFSGLLSGSIRMNSSP- 301
Query: 374 RILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT---TDKILIDVFD 430
LF+ + +I +P + Q ++ ++ ++ L S + +I ++ I +
Sbjct: 302 --LFLHYVLIPMLPAFEPGTGFQPFLK---IYQSMQLVYTSGVYHIAGPGPQQLCISLEP 356
Query: 431 GLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYP 490
L L DV V ++ F HT I +L PK++LD + +P
Sbjct: 357 ALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDER---FP 413
Query: 491 SDFAVEILFGEKMTSSDVVAGS 512
+VE +F +S + + GS
Sbjct: 414 FQASVEFVFS---SSPEKIKGS 432
>gi|38787941 tensin like C1 domain containing phosphatase isoform 1
[Homo sapiens]
Length = 1419
Score = 108 bits (269), Expect = 2e-23
Identities = 86/322 (26%), Positives = 157/322 (48%), Gaps = 24/322 (7%)
Query: 197 FDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKH 256
+DLDLTYVTERI+A +FP+ + +R ++E+ L KHR+ Y ++NL SE+ +D
Sbjct: 139 WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTR 197
Query: 257 FHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLI 316
+ +V + + P L ++ K + W++ D +++V ++CKG + G +V A++
Sbjct: 198 LNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMH 257
Query: 317 ASEICSTAKESLYYFGERR--TDKTHSEKFQGVETPSQKRYVAYFA-QVKHLYNWNLPPR 373
S+I + A ++L R+ DK +E PSQ+RY++YF+ + N P
Sbjct: 258 YSKISAGADQALATLTMRKFCEDKVATEL-----QPSQRRYISYFSGLLSGSIRMNSSP- 311
Query: 374 RILFIKHFIIYSIPRYVRDLKIQIEMEKKVVFSTISLGKCSVLDNIT---TDKILIDVFD 430
LF+ + +I +P + Q ++ ++ ++ L S + +I ++ I +
Sbjct: 312 --LFLHYVLIPMLPAFEPGTGFQPFLK---IYQSMQLVYTSGVYHIAGPGPQQLCISLEP 366
Query: 431 GLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIENNRLYLPKNELDNLHKQKARRIYP 490
L L DV V ++ F HT I +L PK++LD + +P
Sbjct: 367 ALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIHGPQLTFPKDQLDEAWTDER---FP 423
Query: 491 SDFAVEILFGEKMTSSDVVAGS 512
+VE +F +S + + GS
Sbjct: 424 FQASVEFVFS---SSPEKIKGS 442
>gi|239756009 PREDICTED: similar to transmembrane phosphoinositide
3-phosphatase and tensin homolog 2, partial [Homo
sapiens]
Length = 99
Score = 103 bits (258), Expect = 3e-22
Identities = 47/55 (85%), Positives = 49/55 (89%)
Query: 249 ERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGG 303
ERAYDPKHFHNRV RIMIDDHNVPTL +MV F+KEV EWMAQD ENIV IHCKGG
Sbjct: 29 ERAYDPKHFHNRVSRIMIDDHNVPTLREMVAFSKEVLEWMAQDSENIVVIHCKGG 83
>gi|7662146 DnaJ (Hsp40) homolog, subfamily C, member 6 [Homo
sapiens]
Length = 913
Score = 97.4 bits (241), Expect = 3e-20
Identities = 57/180 (31%), Positives = 89/180 (49%), Gaps = 13/180 (7%)
Query: 184 RVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRV 243
RV ++ YT+ DLD TYVT RII MSFP +RN + ++ FLD +H +HY V
Sbjct: 51 RVIQSVTSYTKG--DLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTV 108
Query: 244 YNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGG 303
YNL S ++Y FH+RV P+LH + + + W+ Q+ +N+ +HC G
Sbjct: 109 YNL-SPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDG 167
Query: 304 TDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVE-TPSQKRYVAYFAQV 362
+ +V A I + ST ++ +R G+ +PS +RY+ Y +
Sbjct: 168 RAASSILVGAMFIFCNLYSTPGPAIRLLYAKR---------PGIGLSPSHRRYLGYMCDL 218
>gi|91992155 hydrogen voltage-gated channel 1 [Homo sapiens]
Length = 273
Score = 73.2 bits (178), Expect = 5e-13
Identities = 50/174 (28%), Positives = 87/174 (50%), Gaps = 25/174 (14%)
Query: 3 ESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESSKIKKIVHSIVSSFAFGLFGVF 62
E P PT ++G E G +P + G AP ++K+ SS F + +
Sbjct: 55 EQPPPTPVSG---EEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLF----SSHRFQVIIIC 107
Query: 63 LVLLDVTLILADLIFT------DSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYF 116
LV+LD L+LA+LI D Y + + +S+ I +FF+M+++ ++FV R ++F
Sbjct: 108 LVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFV-FRLEFF 166
Query: 117 SDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHL 170
F ILD ++V+ ++D+V +F + H L L+ILLR++ +
Sbjct: 167 HHKFEILDAVVVVVSFILDIVLLFQE-----------HQFEALGLLILLRLWRV 209
>gi|91992153 hydrogen voltage-gated channel 1 [Homo sapiens]
Length = 273
Score = 73.2 bits (178), Expect = 5e-13
Identities = 50/174 (28%), Positives = 87/174 (50%), Gaps = 25/174 (14%)
Query: 3 ESPDPTDLAGVIIELGPNDSPQTSEFKGATEEAPAKESSKIKKIVHSIVSSFAFGLFGVF 62
E P PT ++G E G +P + G AP ++K+ SS F + +
Sbjct: 55 EQPPPTPVSG---EEGRAAAPDVAPAPGPAPRAPLDFRGMLRKLF----SSHRFQVIIIC 107
Query: 63 LVLLDVTLILADLIFT------DSKLYIPLEYRSISLAIALFFLMDVLLRVFVERRQQYF 116
LV+LD L+LA+LI D Y + + +S+ I +FF+M+++ ++FV R ++F
Sbjct: 108 LVVLDALLVLAELILDLKIIQPDKNNYAAMVFHYMSITILVFFMMEIIFKLFV-FRLEFF 166
Query: 117 SDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHL 170
F ILD ++V+ ++D+V +F + H L L+ILLR++ +
Sbjct: 167 HHKFEILDAVVVVVSFILDIVLLFQE-----------HQFEALGLLILLRLWRV 209
>gi|7657544 sodium channel, voltage gated, type VIII, alpha [Homo
sapiens]
Length = 1980
Score = 45.8 bits (107), Expect = 9e-05
Identities = 35/126 (27%), Positives = 66/126 (52%), Gaps = 7/126 (5%)
Query: 41 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 100
+KI+ IV V+ AF + + L+ L++ ++ + T SK + Y I+L +FF
Sbjct: 1509 NKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETD-TQSKQMENILYW-INLVFVIFFT 1566
Query: 101 MDVLLRVFVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWTHLL 156
+ +L++F R YF+ +NI D ++++ + L D++ +F L + R +
Sbjct: 1567 CECVLKMFA-LRHYYFTIGWNIFDFVVVILSIVGMFLADIIEKYFVSPTLFRVIRLARIG 1625
Query: 157 RLLRLI 162
R+LRLI
Sbjct: 1626 RILRLI 1631
>gi|56786136 sperm-specific sodium proton exchanger [Homo sapiens]
Length = 1177
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/145 (24%), Positives = 73/145 (50%), Gaps = 4/145 (2%)
Query: 45 KIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVL 104
+I H+IV + F G ++L+++ + I + +Y E + + ++++ L
Sbjct: 602 RICHTIVFTEEFEHVGYLVILMNIFPFIISWISQLNVIYHS-ELKHTNYCFLTLYILEAL 660
Query: 105 LRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIIL 164
L++ R+ +FS +NI + AI +I +L ++ IK + N +++++ +
Sbjct: 661 LKI-AAMRKDFFSHAWNIFELAITLIGILHVILIEIDTIKYIFNETEVIVFIKVVQFFRI 719
Query: 165 LRIFHLFHQKRQLEKLIRRRVSENK 189
LRIF L K L ++I +R+S K
Sbjct: 720 LRIFKLIAPK--LLQIIDKRMSHQK 742
>gi|93587342 voltage-gated sodium channel type 4 alpha [Homo sapiens]
Length = 1836
Score = 43.1 bits (100), Expect = 6e-04
Identities = 32/129 (24%), Positives = 70/129 (54%), Gaps = 7/129 (5%)
Query: 38 KESSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIAL 97
+ +KI+ +V+ +V+ AF + + L+ L++ ++ + S+L + + Y +I++ +
Sbjct: 1337 RPQNKIQGMVYDLVTKQAFDITIMILICLNMVTMMVETD-NQSQLKVDILY-NINMIFII 1394
Query: 98 FFLMDVLLRVFVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWT 153
F + +L++ RQ YF+ +NI D ++++ L L D++ +F L + R
Sbjct: 1395 IFTGECVLKMLA-LRQYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTLFRVIRLA 1453
Query: 154 HLLRLLRLI 162
+ R+LRLI
Sbjct: 1454 RIGRVLRLI 1462
>gi|205277447 dual specificity phosphatase 11 [Homo sapiens]
Length = 377
Score = 41.6 bits (96), Expect = 0.002
Identities = 22/76 (28%), Positives = 40/76 (52%), Gaps = 4/76 (5%)
Query: 248 SERAYDPKHFHNRV--VRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLEN--IVAIHCKGG 303
++R Y P+ V ++I H VP + F VN ++ ++ +N ++ +HC G
Sbjct: 143 TQRYYKPEDLPETVPYLKIFTVGHQVPDDETIFKFKHAVNGFLKENKDNDKLIGVHCTHG 202
Query: 304 TDRTGTMVCAFLIASE 319
+RTG ++C +LI E
Sbjct: 203 LNRTGYLICRYLIDVE 218
>gi|26051223 sperm-associated cation channel 2 isoform 2 [Homo
sapiens]
Length = 530
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/130 (25%), Positives = 69/130 (53%), Gaps = 12/130 (9%)
Query: 56 FGLFGVFLVLLDVTLILADLIF---TDSKLY-IPLEYRSISLAIALFFLMDVLLRVFVER 111
F F +FLV L+ +++ ++ T++KL+ + L + I L F++++LL+ ++
Sbjct: 110 FKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK-WLSN 168
Query: 112 RQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLF 171
++ +N+ D + ++ LL +VV +L + + L+LLR+ +LR L
Sbjct: 169 FSVFWKSAWNVFDFVVTMLSLLPEVV-------VLVGVTGQSVWLQLLRICRVLRSLKLL 221
Query: 172 HQKRQLEKLI 181
Q RQ++ +I
Sbjct: 222 AQFRQIQIII 231
>gi|16876443 sperm-associated cation channel 2 isoform 1 [Homo
sapiens]
Length = 528
Score = 41.2 bits (95), Expect = 0.002
Identities = 33/130 (25%), Positives = 69/130 (53%), Gaps = 12/130 (9%)
Query: 56 FGLFGVFLVLLDVTLILADLIF---TDSKLY-IPLEYRSISLAIALFFLMDVLLRVFVER 111
F F +FLV L+ +++ ++ T++KL+ + L + I L F++++LL+ ++
Sbjct: 110 FKNFIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLK-WLSN 168
Query: 112 RQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILLRIFHLF 171
++ +N+ D + ++ LL +VV +L + + L+LLR+ +LR L
Sbjct: 169 FSVFWKSAWNVFDFVVTMLSLLPEVV-------VLVGVTGQSVWLQLLRICRVLRSLKLL 221
Query: 172 HQKRQLEKLI 181
Q RQ++ +I
Sbjct: 222 AQFRQIQIII 231
>gi|53832011 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform b [Homo sapiens]
Length = 2347
Score = 40.8 bits (94), Expect = 0.003
Identities = 32/141 (22%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 41 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 100
S ++ +HS+ +S LF F++ ++V + + L L+Y + I F
Sbjct: 1598 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1657
Query: 101 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 160
+ L F RR +F D +N LD AI+++ L+ + +I++ +P ++R++R
Sbjct: 1658 AALKLVAFGFRR--FFKDRWNQLDLAIVLLSLMGITLE---EIEMSAALPINPTIIRIMR 1712
Query: 161 LIILLRIFHLFHQKRQLEKLI 181
++ + R+ L + L+
Sbjct: 1713 VLRIARVLKLLKMATGMRALL 1733
>gi|53832009 calcium channel, voltage-dependent, T type, alpha 1H
subunit isoform a [Homo sapiens]
Length = 2353
Score = 40.8 bits (94), Expect = 0.003
Identities = 32/141 (22%), Positives = 67/141 (47%), Gaps = 5/141 (3%)
Query: 41 SKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFL 100
S ++ +HS+ +S LF F++ ++V + + L L+Y + I F
Sbjct: 1604 SPTRRSIHSLCTSHYLDLFITFIICVNVITMSMEHYNQPKSLDEALKYCNYVFTIVFVFE 1663
Query: 101 MDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLR 160
+ L F RR +F D +N LD AI+++ L+ + +I++ +P ++R++R
Sbjct: 1664 AALKLVAFGFRR--FFKDRWNQLDLAIVLLSLMGITLE---EIEMSAALPINPTIIRIMR 1718
Query: 161 LIILLRIFHLFHQKRQLEKLI 181
++ + R+ L + L+
Sbjct: 1719 VLRIARVLKLLKMATGMRALL 1739
>gi|51093859 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform b [Homo sapiens]
Length = 2188
Score = 40.8 bits (94), Expect = 0.003
Identities = 26/136 (19%), Positives = 69/136 (50%), Gaps = 5/136 (3%)
Query: 46 IVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLL 105
++HS+ +S +F F++ L+V + + + L L+Y + F+++ +L
Sbjct: 1444 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY--CNYMFTTVFVLEAVL 1501
Query: 106 RVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILL 165
++ +++F D +N LD AI+++ ++ + +I++ +P ++R++R++ +
Sbjct: 1502 KLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE---EIEINAALPINPTIIRIMRVLRIA 1558
Query: 166 RIFHLFHQKRQLEKLI 181
R+ L + L+
Sbjct: 1559 RVLKLLKMATGMRALL 1574
>gi|21361077 calcium channel, voltage-dependent, T type, alpha 1I
subunit isoform a [Homo sapiens]
Length = 2223
Score = 40.8 bits (94), Expect = 0.003
Identities = 26/136 (19%), Positives = 69/136 (50%), Gaps = 5/136 (3%)
Query: 46 IVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIALFFLMDVLL 105
++HS+ +S +F F++ L+V + + + L L+Y + F+++ +L
Sbjct: 1479 LIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKY--CNYMFTTVFVLEAVL 1536
Query: 106 RVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIPRWTHLLRLLRLIILL 165
++ +++F D +N LD AI+++ ++ + +I++ +P ++R++R++ +
Sbjct: 1537 KLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLE---EIEINAALPINPTIIRIMRVLRIA 1593
Query: 166 RIFHLFHQKRQLEKLI 181
R+ L + L+
Sbjct: 1594 RVLKLLKMATGMRALL 1609
>gi|126362955 sodium channel, voltage-gated, type III, alpha isoform 3
[Homo sapiens]
Length = 1951
Score = 39.3 bits (90), Expect = 0.009
Identities = 29/129 (22%), Positives = 64/129 (49%), Gaps = 7/129 (5%)
Query: 38 KESSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIAL 97
+ ++K + +V V+ F + + L+ L++ ++ + D Y+ L I+L +
Sbjct: 1461 RPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET--DDQGKYMTLVLSRINLVFIV 1518
Query: 98 FFLMDVLLRVFVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWT 153
F + +L++ V R YF+ +NI D ++++ + L +++ +F L + R
Sbjct: 1519 LFTGEFVLKL-VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLA 1577
Query: 154 HLLRLLRLI 162
+ R+LRLI
Sbjct: 1578 RIGRILRLI 1586
Score = 38.1 bits (87), Expect = 0.019
Identities = 37/150 (24%), Positives = 63/150 (42%), Gaps = 15/150 (10%)
Query: 31 ATEEAPAKESSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRS 90
+TEE K ++K +SIV F F VF++LL + + I+ + + I
Sbjct: 1134 STEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1193
Query: 91 ISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIP 150
F++++LL+ Q YF++ + LD I+ + L + L+ N
Sbjct: 1194 ADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSL----------VSLVANAL 1243
Query: 151 RWTHL-----LRLLRLIILLRIFHLFHQKR 175
++ L LR LR + LR F R
Sbjct: 1244 GYSELGAIKSLRTLRALRPLRALSRFEGMR 1273
>gi|126362947 sodium channel, voltage-gated, type III, alpha isoform 2
[Homo sapiens]
Length = 1951
Score = 39.3 bits (90), Expect = 0.009
Identities = 29/129 (22%), Positives = 64/129 (49%), Gaps = 7/129 (5%)
Query: 38 KESSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIAL 97
+ ++K + +V V+ F + + L+ L++ ++ + D Y+ L I+L +
Sbjct: 1461 RPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET--DDQGKYMTLVLSRINLVFIV 1518
Query: 98 FFLMDVLLRVFVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWT 153
F + +L++ V R YF+ +NI D ++++ + L +++ +F L + R
Sbjct: 1519 LFTGEFVLKL-VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLA 1577
Query: 154 HLLRLLRLI 162
+ R+LRLI
Sbjct: 1578 RIGRILRLI 1586
Score = 38.1 bits (87), Expect = 0.019
Identities = 37/150 (24%), Positives = 63/150 (42%), Gaps = 15/150 (10%)
Query: 31 ATEEAPAKESSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRS 90
+TEE K ++K +SIV F F VF++LL + + I+ + + I
Sbjct: 1134 STEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1193
Query: 91 ISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIP 150
F++++LL+ Q YF++ + LD I+ + L + L+ N
Sbjct: 1194 ADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSL----------VSLVANAL 1243
Query: 151 RWTHL-----LRLLRLIILLRIFHLFHQKR 175
++ L LR LR + LR F R
Sbjct: 1244 GYSELGAIKSLRTLRALRPLRALSRFEGMR 1273
>gi|126362949 sodium channel, voltage-gated, type III, alpha isoform 1
[Homo sapiens]
Length = 2000
Score = 39.3 bits (90), Expect = 0.009
Identities = 29/129 (22%), Positives = 64/129 (49%), Gaps = 7/129 (5%)
Query: 38 KESSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRSISLAIAL 97
+ ++K + +V V+ F + + L+ L++ ++ + D Y+ L I+L +
Sbjct: 1510 RPANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVET--DDQGKYMTLVLSRINLVFIV 1567
Query: 98 FFLMDVLLRVFVERRQQYFSDLFNILDTAIIVI----LLLVDVVYIFFDIKLLRNIPRWT 153
F + +L++ V R YF+ +NI D ++++ + L +++ +F L + R
Sbjct: 1568 LFTGEFVLKL-VSLRHYYFTIGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTLFRVIRLA 1626
Query: 154 HLLRLLRLI 162
+ R+LRLI
Sbjct: 1627 RIGRILRLI 1635
Score = 38.1 bits (87), Expect = 0.019
Identities = 37/150 (24%), Positives = 63/150 (42%), Gaps = 15/150 (10%)
Query: 31 ATEEAPAKESSKIKKIVHSIVSSFAFGLFGVFLVLLDVTLILADLIFTDSKLYIPLEYRS 90
+TEE K ++K +SIV F F VF++LL + + I+ + + I
Sbjct: 1183 STEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLEY 1242
Query: 91 ISLAIALFFLMDVLLRVFVERRQQYFSDLFNILDTAIIVILLLVDVVYIFFDIKLLRNIP 150
F++++LL+ Q YF++ + LD I+ + L + L+ N
Sbjct: 1243 ADKVFTYIFILEMLLKWVAYGFQTYFTNAWCWLDFLIVDVSL----------VSLVANAL 1292
Query: 151 RWTHL-----LRLLRLIILLRIFHLFHQKR 175
++ L LR LR + LR F R
Sbjct: 1293 GYSELGAIKSLRTLRALRPLRALSRFEGMR 1322
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.327 0.142 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,004,730
Number of Sequences: 37866
Number of extensions: 765781
Number of successful extensions: 2587
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 49
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 2391
Number of HSP's gapped (non-prelim): 233
length of query: 513
length of database: 18,247,518
effective HSP length: 107
effective length of query: 406
effective length of database: 14,195,856
effective search space: 5763517536
effective search space used: 5763517536
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.