BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens] (739 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens] 1459 0.0 gi|142976638 sine oculis homeobox homolog 4 [Homo sapiens] 313 5e-85 gi|219275578 SIX homeobox 2 [Homo sapiens] 230 3e-60 gi|5174681 SIX homeobox 1 [Homo sapiens] 223 4e-58 gi|4885597 sine oculis homeobox homolog 3 [Homo sapiens] 223 5e-58 gi|186910311 SIX homeobox 6 [Homo sapiens] 211 1e-54 gi|146219843 Snf2-related CBP activator protein [Homo sapiens] 72 2e-12 gi|7662236 TSC22 domain family, member 2 [Homo sapiens] 69 2e-11 gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 67 6e-11 gi|163965366 nascent polypeptide-associated complex alpha subuni... 67 8e-11 gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] 66 1e-10 gi|110832843 TBP-associated factor 4 [Homo sapiens] 65 2e-10 gi|160707881 formin 2 [Homo sapiens] 64 4e-10 gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens] 63 9e-10 gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 62 2e-09 gi|47132519 Ras association and pleckstrin homology domains 1 is... 62 2e-09 gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens] 62 3e-09 gi|112734870 hypothetical protein LOC57648 [Homo sapiens] 61 4e-09 gi|112382226 atrophin-1 like protein isoform b [Homo sapiens] 60 6e-09 gi|112382224 atrophin-1 like protein isoform a [Homo sapiens] 60 6e-09 gi|112382216 atrophin-1 like protein isoform a [Homo sapiens] 60 6e-09 gi|149773456 hypothetical protein LOC643314 [Homo sapiens] 60 7e-09 gi|239742468 PREDICTED: double homeobox, 4-like [Homo sapiens] 60 7e-09 gi|194272172 double homeobox, 4 [Homo sapiens] 60 7e-09 gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho... 60 7e-09 gi|194272217 double homeobox, 4-like [Homo sapiens] 60 7e-09 gi|194272216 double homeobox, 4-like [Homo sapiens] 60 7e-09 gi|194272215 double homeobox, 4-like [Homo sapiens] 60 7e-09 gi|194272192 double homeobox, 4-like [Homo sapiens] 60 7e-09 gi|91982772 mucin 17 [Homo sapiens] 60 1e-08 >gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens] Length = 739 Score = 1459 bits (3776), Expect = 0.0 Identities = 739/739 (100%), Positives = 739/739 (100%) Query: 1 MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAG 60 MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAG Sbjct: 1 MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAG 60 Query: 61 AEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERL 120 AEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERL Sbjct: 61 AEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERL 120 Query: 121 RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRAL 180 RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRAL Sbjct: 121 RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRAL 180 Query: 181 GAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGL 240 GAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGL Sbjct: 181 GAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGL 240 Query: 241 SLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA 300 SLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA Sbjct: 241 SLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA 300 Query: 301 QGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLL 360 QGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLL Sbjct: 301 QGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLL 360 Query: 361 LTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEE 420 LTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEE Sbjct: 361 LTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEE 420 Query: 421 VLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP 480 VLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP Sbjct: 421 VLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP 480 Query: 481 TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL 540 TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL Sbjct: 481 TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL 540 Query: 541 LANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGL 600 LANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGL Sbjct: 541 LANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGL 600 Query: 601 PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA 660 PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA Sbjct: 601 PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA 660 Query: 661 AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEA 720 AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEA Sbjct: 661 AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEA 720 Query: 721 EAKVLTQLQSVPVEEPLEL 739 EAKVLTQLQSVPVEEPLEL Sbjct: 721 EAKVLTQLQSVPVEEPLEL 739 >gi|142976638 sine oculis homeobox homolog 4 [Homo sapiens] Length = 781 Score = 313 bits (801), Expect = 5e-85 Identities = 190/370 (51%), Positives = 232/370 (62%), Gaps = 37/370 (10%) Query: 5 PAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGP 64 P P+ P G+A AAA EE AAAAAGA A +E Sbjct: 45 PPAPAPFPLEPGDAATAAARVSGEEGAV-------------AAAAAGAAADQVQLHSELL 91 Query: 65 GSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSD 124 G AA+ T L FSP+ VACVCEAL Q G+ RL+RFL +LP ++ LRG++ Sbjct: 92 GR-----HHHAAAAAAQTPLAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNE 146 Query: 125 PVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVD 184 +L+ARALVAF +G Y ELY +LES F +A+H LQ L+ +ARY EAERARGR LGAVD Sbjct: 147 SLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVD 206 Query: 185 KYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQ 244 KYRLR+KFPLP+TIWDGEETVYCFKE+SR ALK Y+ NRYP+P EKR LA +TGLSLTQ Sbjct: 207 KYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQ 266 Query: 245 VSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGS- 303 VSNWFKNRRQRDR + KSESDGNP+TEDESS+ EDL S++ S Sbjct: 267 VSNWFKNRRQRDRNPS--ETQSKSESDGNPSTEDESSKGHEDLSPHPLSSSSDGITNLSL 324 Query: 304 ------IFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNG-----GP--VIINGLAL 350 +++ G +SS +L+NGS + AS SP V LNG GP VI+NGL + Sbjct: 325 SSHMEPVYMQQIGNAKISLSSSGVLLNGSLVPASTSP-VFLNGNSFIQGPSGVILNGLNV 383 Query: 351 G--EASSLGP 358 G +A +L P Sbjct: 384 GNTQAVALNP 393 >gi|219275578 SIX homeobox 2 [Homo sapiens] Length = 291 Score = 230 bits (587), Expect = 3e-60 Identities = 135/289 (46%), Positives = 173/289 (59%), Gaps = 31/289 (10%) Query: 86 FSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYR 145 F+ EQVACVCE L Q G+ RL RFL +LP E L ++ VL+A+A+VAF RG + ELY+ Sbjct: 9 FTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYK 68 Query: 146 LLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETV 205 +LES F +HA LQ L+L+A Y EAE+ RGR LGAV KYR+R+KFPLP++IWDGEET Sbjct: 69 ILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETS 128 Query: 206 YCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAP 265 YCFKE+SR+ L+ Y N YP+P EKR LA TGL+ TQVSNWFKNRRQRDR Sbjct: 129 YCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA------- 181 Query: 266 CKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNG 325 +E+ E+ +S S L V + + + P+ P S Sbjct: 182 --AEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKT--------PSGTPDHS------ 225 Query: 326 SFLAASGSPAVLLNGGPVIINGL-ALGE--ASSLGPLLLTGGGGAPPPQ 371 S SPA+LL+ P + L +LG S P+ + GGGGA P Q Sbjct: 226 -----SSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQ 269 >gi|5174681 SIX homeobox 1 [Homo sapiens] Length = 284 Score = 223 bits (569), Expect = 4e-58 Identities = 120/248 (48%), Positives = 159/248 (64%), Gaps = 12/248 (4%) Query: 86 FSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYR 145 F+ EQVACVCE L Q G+ RL RFL +LP + L ++ VL+A+A+VAF RG + ELY+ Sbjct: 9 FTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYK 68 Query: 146 LLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETV 205 +LES F +H LQ L+L+A Y EAE+ RGR LGAV KYR+R+KFPLP+TIWDGEET Sbjct: 69 ILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETS 128 Query: 206 YCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAP 265 YCFKE+SR L+ Y N YP+P EKR LA TGL+ TQVSNWFKNRRQRDR A Sbjct: 129 YCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDR--AAEAKE 186 Query: 266 CKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNG 325 ++ + N ++ ++ SP + G P+ + + + S PP +S +L+ G Sbjct: 187 RENTENNNSSSNKQNQLSPLE---GGKPLMSSSEEEFS-------PPQSPDQNSVLLLQG 236 Query: 326 SFLAASGS 333 + A S Sbjct: 237 NMGHARSS 244 >gi|4885597 sine oculis homeobox homolog 3 [Homo sapiens] Length = 332 Score = 223 bits (568), Expect = 5e-58 Identities = 136/292 (46%), Positives = 170/292 (58%), Gaps = 23/292 (7%) Query: 44 GEAAAAAGAGAGAAAAGAEGPGSPGVPGS--PPEAAS--EPPTGLRFSPEQVACVCEALL 99 G A +G G GA GA G G G GS PPE S + PT L FSPEQVA VCE L Sbjct: 42 GGAGGGSGGGNGAGGGGAGGAGGGGGGGSRAPPEELSMFQLPT-LNFSPEQVASVCETLE 100 Query: 100 QAGHAGRLSRFLGALPPA----ERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAA 155 + G RL RFL +LP A E + + +LRARA+VAF G + +LY +LE+ F Sbjct: 101 ETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKE 160 Query: 156 HHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAA 215 H LQ ++L A Y EAE+ RGR LG VDKYR+RKKFPLP+TIWDGE+ +CFKER+R+ Sbjct: 161 SHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSL 220 Query: 216 LKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAG---------GGAPC 266 L+ Y + YP P +KR LA TGL+ TQV NWFKNRRQRDR A G + Sbjct: 221 LREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGM 280 Query: 267 KSESD-GNPTTEDESSRSPEDLERGAAPVSA--EAAAQGSIFLAGTGPPAPC 315 +S ++ G PT S+ SP VS+ E A G+ L+ T + C Sbjct: 281 RSLAEPGCPT--HGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSEC 330 >gi|186910311 SIX homeobox 6 [Homo sapiens] Length = 246 Score = 211 bits (538), Expect = 1e-54 Identities = 112/207 (54%), Positives = 134/207 (64%), Gaps = 16/207 (7%) Query: 84 LRFSPEQVACVCEALLQAGHAGRLSRFLGALPPA----ERLRGSDPVLRARALVAFQRGE 139 L FSP+QVA VCE L ++G RL RFL +LP A E L ++ VLRARA+VAF G Sbjct: 7 LNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGN 66 Query: 140 YAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIW 199 Y ELY +LE+ F HA LQ L+L A Y EAE+ RGR LG VDKYR+RKKFPLP+TIW Sbjct: 67 YRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIW 126 Query: 200 DGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTG 259 DGE+ +CFKER+R L+ Y + YP P +KR LA TGL+ TQV NWFKNRRQRDR Sbjct: 127 DGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAA 186 Query: 260 A------------GGGAPCKSESDGNP 274 A G G ++E DG P Sbjct: 187 AAKNRLQQQVLSQGSGRALRAEGDGTP 213 >gi|146219843 Snf2-related CBP activator protein [Homo sapiens] Length = 3230 Score = 71.6 bits (174), Expect = 2e-12 Identities = 103/363 (28%), Positives = 140/363 (38%), Gaps = 74/363 (20%) Query: 358 PLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLE-----EAQSEAPET----KGA 408 P L G +P P P+ + +S V P + + + A + AP T Sbjct: 1404 PSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPL 1463 Query: 409 QVAAPGPALGEEVLGPLAQVV---PGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTG 465 V+A GPAL V PLA VV PGPP+ A P G P+ +A + L+ P + Sbjct: 1464 TVSASGPALLTSVTPPLAPVVPAAPGPPSLA----PSGASPSASA-LTLGLATAPSLSSS 1518 Query: 466 LSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGV 525 +P PLL + PTS V PG VA A P V Sbjct: 1519 QTPGHPLL----LAPTSSHV---------------PGLNSTVAPACSPVL-------VPA 1552 Query: 526 TALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLAL 585 +AL P +AP NP A Q ++ A+ + L + + P A Sbjct: 1553 SALASPFPSAP------NP----------APAQASLLAPASSASQALATPLAPMA----- 1591 Query: 586 PLKPETAISVPEGGLPVAPSPAL-PEAHALGTL-SAQQPPPAAATTSSTSLPFSPDSPGL 643 P+TAI P P+AP P L P A L S+Q P P A +S+ + SP Sbjct: 1592 --APQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVP 1649 Query: 644 LPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEA---EKGLGTQAPHTVLRLPDPD 700 P P + PA VP + L A T+ L A LG +P L L + Sbjct: 1650 APTPVLAPSSTQTMLPAPVP---SPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGN 1706 Query: 701 PEG 703 P+G Sbjct: 1707 PQG 1709 Score = 63.5 bits (153), Expect = 7e-10 Identities = 102/392 (26%), Positives = 150/392 (38%), Gaps = 66/392 (16%) Query: 268 SESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP--PAPCPASSSILVNG 325 S++ G+P +S L AP + S LA P P P PA +S+L Sbjct: 1518 SQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASA-LASPFPSAPNPAPAQASLLAP- 1575 Query: 326 SFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLV 385 A+S S A+ P +A + + L P APP P P V Sbjct: 1576 ---ASSASQALATPLAP-----MAAPQTAILAP------SPAPPLAPLP----------V 1611 Query: 386 LDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATF-PLP-PG 443 L P G + A S+ P A + PG +L P V P + T P P P Sbjct: 1612 LAPSPGAAPVL-ASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPS 1670 Query: 444 PVPAVAAPQVVPLSPP-----------------PGYPTGLSPTSPLLNLP--QVVPT-SQ 483 P+P+ A+ Q + L+P G P G PT L P +VPT +Q Sbjct: 1671 PLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQ 1730 Query: 484 VVTLPQA--VGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLL 541 ++L +GP Q L+ P P+ A+ GPA H + ++ L + + L Sbjct: 1731 TLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTL 1790 Query: 542 ANPVSGSPIVT-GVAVQQGKIILTAT--FPTSMLVSQVLPPAPGLALPLKPETAISVPE- 597 S +P+ T G A Q + A+ P S S V+ + LP+ + + V + Sbjct: 1791 ----SPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKD 1846 Query: 598 --GGLPVAPSPALPEAHAL---GTLSAQQPPP 624 L + P P + A G +QPPP Sbjct: 1847 EPDTLTLRSGPPSPPSTATSFGGPRPRRQPPP 1878 Score = 56.2 bits (134), Expect = 1e-07 Identities = 124/487 (25%), Positives = 173/487 (35%), Gaps = 101/487 (20%) Query: 293 PVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGE 352 P +A + + T PAP PA ++++ A L G V+ ++G+ Sbjct: 1141 PAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQAR-------LPSGEVV----SIGQ 1189 Query: 353 ASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDP---------QTGEVRLEEAQ---- 399 +SL + GG+ P QG T T + Q V L A Sbjct: 1190 LASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHH 1249 Query: 400 --SEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVP-- 455 S+ Q AP P GP V T +T P P G +AA QV P Sbjct: 1250 LISQPAHVALIQAVAPTP-------GPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTM 1302 Query: 456 ------------------LSPPPGYPTGLSPTSPLLNLPQV-----------VPTSQVVT 486 L+P P P +P P LP V +PT + T Sbjct: 1303 VNNTGVVKIVVRQAPRDGLTPVP--PLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGT 1360 Query: 487 ------LPQAVGPLQLLAAGPGSPVKVAA-AAGPANV----HLINSGVGVTALQLPSATA 535 P V PL L P V +A A P + H+ +S G + +P Sbjct: 1361 ARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMP---I 1417 Query: 536 PGNFLLANPVSGS---PIVTGVAVQQGKII-LTATFPTSMLVS---QVLPPAPGLALPLK 588 P + LA+PVS + P+ + + + + A+ P ++ +S V P L + Sbjct: 1418 PNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVT 1477 Query: 589 PETAISVPEGGLP--VAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDS---PGL 643 P A VP P +APS A P A AL A P +++ T L +P S PGL Sbjct: 1478 PPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGL 1537 Query: 644 LPNF-PAPPPEGLMLSPAAVPVWSAGLELSAGTEGLL---EAEKGLGT-----QAPHTVL 694 PA P + S A P SA A L A + L T AP T + Sbjct: 1538 NSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAI 1597 Query: 695 RLPDPDP 701 P P P Sbjct: 1598 LAPSPAP 1604 Score = 53.1 bits (126), Expect = 9e-07 Identities = 67/272 (24%), Positives = 95/272 (34%), Gaps = 48/272 (17%) Query: 368 PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVL-GPLA 426 PPP+P P + + Q G + AP PGP L + GP+ Sbjct: 983 PPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTPGPVP 1042 Query: 427 QVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLL-NLPQVVPTSQVV 485 QV+P + P A P ++P S PPG P L P P +LPQV+P+ V Sbjct: 1043 QVLPASLMVSASP---------AGPPLIPASRPPG-PVLLPPLQPNSGSLPQVLPSPLGV 1092 Query: 486 TLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPV 545 + P L+ P P V +L A PG+ L P+ Sbjct: 1093 LSGTSRPPTPTLSLKPTPPAPV---------------------RLSPAPPPGSSSLLKPL 1131 Query: 546 SGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPG-LALPLKPETAISVPEGGLPVAP 604 + P G T+T + + V P P L L P+ +P G Sbjct: 1132 TVPP---GYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSG------ 1182 Query: 605 SPALPEAHALGTLSAQQPPPAAATTSSTSLPF 636 E ++G L++ P A S L F Sbjct: 1183 -----EVVSIGQLASLAQRPVANAGGSKPLTF 1209 Score = 49.3 bits (116), Expect = 1e-05 Identities = 81/320 (25%), Positives = 122/320 (38%), Gaps = 73/320 (22%) Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426 AP P+P+P A +LV P + V ++AP P V Sbjct: 2440 APRPRPTPASAPAAIPALVPVPVSAPV---------------PISAPNPITILPV----- 2479 Query: 427 QVVPGPPTAATFPLPPGPVPAVAAPQVVPL---------SPPPGYPTGLSPTSPLLNLPQ 477 ++P PP PP +P ++P P +PPP ++P+SPLL P Sbjct: 2480 HILPSPP-------PPSQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPP 2532 Query: 478 VVPTSQVVT-LPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAP 536 VP S VT LP + P L A A A P ++ L + V + S P Sbjct: 2533 SVPISASVTNLPLGLRPEAELCA--------QALASPESLEL--ASVASSETSSLSLVPP 2582 Query: 537 GNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPE--TAIS 594 + L PV+ V + V + + LT + P+ L + +P P E T Sbjct: 2583 KDLL---PVA----VEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTV 2635 Query: 595 VPEG-GLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPD------SPGLLPNF 647 +PEG LP+ S E++ L + PP+AA+ P D + P Sbjct: 2636 LPEGEELPLCVS----ESNGL------ELPPSAASDEPLQEPLEADRTSEELTEAKTPTS 2685 Query: 648 PAPPPEGLMLSPAAVPVWSA 667 P+ L+ + A P S+ Sbjct: 2686 SPEKPQELVTAEVAAPSTSS 2705 Score = 45.1 bits (105), Expect = 2e-04 Identities = 81/307 (26%), Positives = 115/307 (37%), Gaps = 47/307 (15%) Query: 209 KERSRAALKACYRGNRYP-TPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGG-APC 266 + R+ A ++ +G P P + L L G +T V RR+R + GA P Sbjct: 2721 RRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPG 2780 Query: 267 KSESDGNPTTEDESSRS-PEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILV-- 323 SE+ +P + S S PE P EAA S+ T P P A I + Sbjct: 2781 VSETSASPGSPSVRSMSGPESSPPIGGP--CEAAPSSSL---PTPPQQPFIARRHIELGV 2835 Query: 324 ---------NGSFLAASGSPAVLLNGGPVIIN------GLALGEASSLGPLLLTGGGGAP 368 +G+ LA + G P N G + EA S L G Sbjct: 2836 TGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSS---TLKGKTNGA 2892 Query: 369 PPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQ-VAAPGPALGEEVLGPLAQ 427 P P P+ T +V DP LE P+ G Q V P P +L P+ + Sbjct: 2893 DPVPGPE------TLIVADPV-----LEPQLIPGPQPLGPQPVHRPNP-----LLSPVEK 2936 Query: 428 VVPG-PPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVT 486 G PP A P+P G + + + PP +P+ L+P PLL P + V T Sbjct: 2937 RRRGRPPKARDLPIP-GTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTT 2995 Query: 487 LPQAVGP 493 + + P Sbjct: 2996 VTISTSP 3002 Score = 35.0 bits (79), Expect = 0.25 Identities = 24/72 (33%), Positives = 32/72 (44%), Gaps = 6/72 (8%) Query: 370 PQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVL-GPLAQV 428 P P+ +T +V D TG + A S +P + GA +P + L GP Sbjct: 5 PSPAHPQLPVLQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGP---- 60 Query: 429 VPGPPTAATFPL 440 PGPP AT PL Sbjct: 61 -PGPPDGATVPL 71 Score = 30.8 bits (68), Expect = 4.7 Identities = 51/184 (27%), Positives = 72/184 (39%), Gaps = 32/184 (17%) Query: 287 LERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIIN 346 L P AAAQ ++ LA +P +SS++V+ S A+ P +++ PV + Sbjct: 1790 LSPAPVPTLGPAAAQ-TLALAPASTQSPASQASSLVVSAS--GAAPLPVTMVSRLPVSKD 1846 Query: 347 G---LALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAP 403 L L P T GG P+P Q ++ LD E + + +SE Sbjct: 1847 EPDTLTLRSGPPSPPSTATSFGG---PRPRRQPPPPPRSPFYLDSL--EEKRKRQRSERL 1901 Query: 404 ETKGAQVAAPG---PALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPP 460 E A G P G EVL T P P VA+P + P SP P Sbjct: 1902 ERIFQLSEAHGALAPVYGTEVLD-----------FCTLPQP------VASP-IGPRSPGP 1943 Query: 461 GYPT 464 +PT Sbjct: 1944 SHPT 1947 >gi|7662236 TSC22 domain family, member 2 [Homo sapiens] Length = 780 Score = 68.6 bits (166), Expect = 2e-11 Identities = 93/333 (27%), Positives = 124/333 (37%), Gaps = 62/333 (18%) Query: 366 GAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPL 425 G P P P P G + ++S L P G A P AQ + P A GP Sbjct: 272 GQPQPPPPPVGGAVAQSSAPLPPFPG-----AATGPQPMMAAAQPSQPQGA------GPG 320 Query: 426 AQVVPGPPTAAT-----FPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP 480 Q + PPT T LPP P PAV AP YP P P +L V P Sbjct: 321 GQTL--PPTNVTLAQPAMSLPPQPGPAVGAP-AAQQPQQFAYP---QPQIPPGHLLPVQP 374 Query: 481 TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTA----LQLPSATAP 536 + Q L Q V LQ P P AAA PA + G G A QL A++ Sbjct: 375 SGQSEYLQQHVAGLQ--PPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQ 432 Query: 537 GNFLLA---NPVSGSPIV----TGV-AVQQGKIILTATFPTSMLVSQVLPPAPGLALPLK 588 + +A P G + TGV G ++ P Q +PP Sbjct: 433 PSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPP--------- 483 Query: 589 PETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFP 648 P+ S P +P P +P + + A P P+ + S+TS+ +PN P Sbjct: 484 PQMGGSGPLSAVPGGPHAVVP---GVPNVPAAVPAPSVPSVSTTSV--------TMPNVP 532 Query: 649 APPPEGLMLSP------AAVPVWSAGLELSAGT 675 AP + LS ++ + GL L+ GT Sbjct: 533 APLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGT 565 Score = 43.5 bits (101), Expect = 7e-04 Identities = 94/371 (25%), Positives = 122/371 (32%), Gaps = 78/371 (21%) Query: 314 PCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSL---------------GP 358 P S ++L++G AA+ +PA NGG V+ G +S GP Sbjct: 81 PGTVSPNLLLDGQLAAAAAAPA---NGGGVVSARSVSGALASTLAAAATSAPAPGAPGGP 137 Query: 359 LLLTGGGG---APPPQPSPQGASETKTSLVLDPQTGE---------VRLEEAQSEAPETK 406 L G A P QP P S + LD +GE + E S++ Sbjct: 138 QLAGSSAGPVTAAPSQP-PTTCSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLT 196 Query: 407 GA-----------QVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVP 455 + Q A LG G VV A P G ++ A +P Sbjct: 197 RSGDCIRHSSTFDQTAERDSGLG--ATGGSVVVVVASMQGAHGP-ESGTDSSLTAVSQLP 253 Query: 456 LSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPAN 515 S PT P S + PQ P + Q+ PL P + AAA P+ Sbjct: 254 PSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQ 313 Query: 516 VHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQ 575 G G LP P N LA P P G AV P + Q Sbjct: 314 ----PQGAGPGGQTLP----PTNVTLAQPAMSLPPQPGPAVGA---------PAAQQPQQ 356 Query: 576 VLPPAPGLALPLKPETAISVPEGG-LPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSL 634 P P +P G LPV PS ++ L A PP+ A SST Sbjct: 357 FAYPQP------------QIPPGHLLPVQPS---GQSEYLQQHVAGLQPPSPAQPSSTGA 401 Query: 635 PFSPDSPGLLP 645 SP + LP Sbjct: 402 AASPATAATLP 412 Score = 30.4 bits (67), Expect = 6.2 Identities = 22/73 (30%), Positives = 29/73 (39%), Gaps = 8/73 (10%) Query: 6 AEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGPG 65 A +A PA GG V+A + + L + AA +A A GA G AG+ Sbjct: 95 AAAAAAPANGGGVVSARSVSGA--------LASTLAAAATSAPAPGAPGGPQLAGSSAGP 146 Query: 66 SPGVPGSPPEAAS 78 P PP S Sbjct: 147 VTAAPSQPPTTCS 159 >gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens] Length = 1124 Score = 67.0 bits (162), Expect = 6e-11 Identities = 85/311 (27%), Positives = 116/311 (37%), Gaps = 58/311 (18%) Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426 +PP PS S+ SL P L+ S + A P P + P Sbjct: 682 SPPVSPSATPPSQAPPSLAAPP------LQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 735 Query: 427 QVVPGPPTAATFPLPPGPVPAVAAPQVV---PLSPPPGYPTGLSPTSPLLNLPQVVPTSQ 483 QV P PP A+ P+ P P P ++ PL PP P L P SPL P P + Sbjct: 736 QVPPSPP--ASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASL-PMSPLAKPPPQAPPA- 791 Query: 484 VVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLAN 543 A PLQ L + P S A + PSA+ P + L Sbjct: 792 -----LATPPLQALPSPPASFPGQAPFS-------------------PSASLPMSPLATP 827 Query: 544 PVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVA 603 P P++ +Q + + + L + PP PG P+T++S P L +A Sbjct: 828 PPQAPPVLAAPLLQ----VPPSPPASPTLQAPRRPPTPG------PDTSVSGPRLTLALA 877 Query: 604 PSPALPEAHA-LGTLSAQQPPPAAATTSSTSLP-----FSPDSPGLLPNFPAPPPEGLML 657 P P P + + TLS P A ++S+TS P + G P P E Sbjct: 878 PGPPPPPSRSPSSTLSG--PDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAAC 935 Query: 658 SPAAVPVWSAG 668 PAA WS G Sbjct: 936 HPAA---WSRG 943 Score = 65.9 bits (159), Expect = 1e-10 Identities = 116/468 (24%), Positives = 160/468 (34%), Gaps = 83/468 (17%) Query: 292 APVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGL--- 348 +P +A+ A T P +P + L L S SPAV P+ I+ L Sbjct: 433 SPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQAL 492 Query: 349 -ALGEASSLGPL-------LLTGGGGAPPPQPSPQGASETKT-----SLVLDP-QTGEVR 394 +L S PL L T APP +P + T SL P QT Sbjct: 493 SSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAP 552 Query: 395 LEEAQSEAPETKG-------------------AQVAAPGPALGEEVLGPLAQVVPGPPTA 435 L E P + +A P P + P Q +P PP + Sbjct: 553 LTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLS 612 Query: 436 ATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQA----- 490 PP P +A P PL PP P P SPL P + V L QA Sbjct: 613 PLATPPPQAPPXLALP---PLQAPPS-PPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 668 Query: 491 -VGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSP 549 P+Q + P SP +A P+ + + P A+ P + P P Sbjct: 669 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 728 Query: 550 IVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETA--------ISVPEGGLP 601 + +Q +PP+P + P+ P ++ P +P Sbjct: 729 PLAAPPLQ-------------------VPPSPPASPPMSPSATPPPRVPPLLAAPPLQVP 769 Query: 602 VAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDS-PGLLPNFPAPPPEGLMLSPA 660 +P +LP + Q PPA AT +LP P S PG P P L +SP Sbjct: 770 PSPPASLPMSPL--AKPPPQAPPALATPPLQALPSPPASFPG---QAPFSPSASLPMSPL 824 Query: 661 AVPVWSAGLELSAGTEGLLEAEKGLGT-QAPHTVLRLPDPDPEGLLLG 707 A P A L+A + + T QAP R P P P+ + G Sbjct: 825 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR---RPPTPGPDTSVSG 869 Score = 63.9 bits (154), Expect = 5e-10 Identities = 86/364 (23%), Positives = 124/364 (34%), Gaps = 35/364 (9%) Query: 362 TGGGGAPPPQPSPQGASETKTSLVL--DPQTGEVRLEEAQSEAPETKGAQVAAP------ 413 + GGG P +S T S P A P+ KG Q P Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP 288 Query: 414 ----GPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPT 469 PALG PLA P P P+PP A P +P SPP P L+P Sbjct: 289 RKDAAPALGPLSSSPLA--TPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPP 346 Query: 470 SPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQ 529 S P P+ Q + P A P Q + P++ + + + +LQ Sbjct: 347 S-----PSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQ 401 Query: 530 LPSATAPGNFLLANPVSGSPIVTG------VAVQQGKIILTATFPTSMLVSQVLPPAPGL 583 P + + L A GSP + ++ +Q + LT+ + P L Sbjct: 402 APPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPL 461 Query: 584 ALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGL 643 +LP P S+ P++ + AL +L++ P A SS +P L Sbjct: 462 SLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSP---QAPLSSLIMPPLETQSSL 518 Query: 644 LPNFPAPPPEGLMLSP-------AAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRL 696 P PP L P A P+ +A L+ QAP + L Sbjct: 519 APPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTT 578 Query: 697 PDPD 700 P P+ Sbjct: 579 PPPE 582 Score = 55.5 bits (132), Expect = 2e-07 Identities = 117/461 (25%), Positives = 160/461 (34%), Gaps = 97/461 (21%) Query: 290 GAAPVSAEAAAQGSIFLAGTGPPAPCP--ASSSILVNGSFLAASGSPAVLLNGGPVIING 347 GAA + A A G + G P P P +++ V G+ A P GG I G Sbjct: 11 GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG---IGG 67 Query: 348 LALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKG 407 + E+ AP P+ + ++ P +G E A T Sbjct: 68 ATIPES-------------APRAGPTRSAGTSSRNPASRPPASGR---GERAPPAKNTSP 111 Query: 408 AQVAAPGPALGEEVLGPLAQ----------VVPGPPTAA--------------TFPLPPG 443 V++PG A G GPL Q V G T A + P P Sbjct: 112 GPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGT 171 Query: 444 PVPAVA---------------APQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488 P PA+A AP P P G +S S P+ P Sbjct: 172 PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSAS---EHSTTEPSPAARRRP 228 Query: 489 QAVGPLQLLA----AGPGSPVKVAAAAGP-------ANVHLIN-SGVGVTALQLPSATAP 536 A G LQ A + +P+ A +GP A H G+ AL+ P T P Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP 288 Query: 537 GNFL--LANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLA--LPLKPETA 592 P+S SP+ T + + + LPP+P LA LPL P + Sbjct: 289 RKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSP 348 Query: 593 ISVPEGGLPVAPS-PALPEAHALGTLSA--QQPPPAAATTSSTSLPFSPDSPGLLPNFPA 649 + P L PS PA P + A +++ Q PP+ T +P S SP L A Sbjct: 349 SAPP--SLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSL----QA 402 Query: 650 PPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAP 690 PP SP A+ A L + T L+A T +P Sbjct: 403 PP------SPLALSSLQATTSLGSPT---LQATHSFLTMSP 434 >gi|163965366 nascent polypeptide-associated complex alpha subunit isoform a [Homo sapiens] Length = 2078 Score = 66.6 bits (161), Expect = 8e-11 Identities = 118/453 (26%), Positives = 161/453 (35%), Gaps = 52/453 (11%) Query: 272 GNPTTEDESSRSPED-----LERGA--APVSAEAAAQGSIFLAGTGPP--APC-PASSSI 321 G PTT + SP+ +GA P + + +G + T PP AP PA++ Sbjct: 1124 GAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL---ATPPPKGAPTTPAATPP 1180 Query: 322 LVNGSFLAAS--GSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQ-----PSP 374 G S G+P P GLA T P P+ PSP Sbjct: 1181 SPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT---TPAATPPSPKGGLATPSP 1237 Query: 375 QGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQV--AAPGPALGEEVLGPLAQVVPGP 432 +GA T + P+ G P KGA AA P+L + P + P P Sbjct: 1238 KGAPTTPAATPPSPKGGPA--------TPPPKGAPTPPAATPPSLKGGLATPPHKGAPNP 1289 Query: 433 PTAATFPLPPGPVPAVAAPQVVPLSPP--PGYPTGLSPTSPLLNLPQVVPTSQVVTLPQA 490 A P P PA + P+ P P P P G T P P+ PT VT P Sbjct: 1290 --AVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPP----PKGAPTPPAVTPPSP 1343 Query: 491 VGPLQLLAAGP---GSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSG 547 G L A P G P ++ GP S G A+ PS Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPT 1403 Query: 548 SPIVTGVAVQQGKII-LTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSP 606 SP V ++ ++ +T + + PPA + LK A S P+GG S Sbjct: 1404 SPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAV-TPVSLKKAPATSAPKGGPATPSSK 1462 Query: 607 ALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLL--PNFPAPPPEGLMLSPAAVPV 664 P A+ S ++PP +S+S +P +P + P PA P SP VP Sbjct: 1463 GDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPS----SPKEVPA 1518 Query: 665 WSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLP 697 + L ++K T AP L P Sbjct: 1519 TPSSRRDPIAPTATLLSKKTPATLAPKEALIPP 1551 Score = 65.5 bits (158), Expect = 2e-10 Identities = 114/457 (24%), Positives = 169/457 (36%), Gaps = 75/457 (16%) Query: 227 TPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPED 286 TP + AT + LT + + ++ T A G P S G+PT + SP++ Sbjct: 1418 TPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKE 1477 Query: 287 ------LERGAAPVSAEA--AAQGSIFLAGTGPPAP--CPASSSI----LVNGSFLAASG 332 + ++P A A A G+ L P +P PA+ S + + L + Sbjct: 1478 PPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKK 1537 Query: 333 SPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGE 392 +PA L + + + P + P P+P+ A T +S Sbjct: 1538 TPATLAP------------KEALIPPAMTVPSPKKTPAIPTPKEAPATPSS--------- 1576 Query: 393 VRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP--LPPGPV--PAV 448 +EA S T AP P +E+L P A P P A T P PP P PA Sbjct: 1577 ---KEASSPPAVTPSTYKGAPSP---KELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPAT 1630 Query: 449 AAPQVVPLSPPPGYPTGL--SPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVK 506 AP+ P SPP P+ L SPTS P V T+PQA L GP + + Sbjct: 1631 PAPKGTPTSPPV-TPSSLKDSPTS-----PASVTCKMGATVPQASKGLP-AKKGPTALKE 1683 Query: 507 VAAAAGPANVHLINSGVGV-TALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTA 565 V A P + +I + + SAT+P P+ P + +G + A Sbjct: 1684 VLVAPAPESTPIITAPTRKGPQTKKSSATSP-------PICPDPSAKNGS--KGPLSTVA 1734 Query: 566 TFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPA-----LPEAHALGTLSAQ 620 P + A G P+ ++ PE + A LP+ + +A Sbjct: 1735 PAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAP 1794 Query: 621 QPP------PAAATTSSTSLPFSPDSPGLLPNFPAPP 651 PP P+ T F P SPGL+ P+ P Sbjct: 1795 SPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKP 1831 Score = 63.5 bits (153), Expect = 7e-10 Identities = 106/405 (26%), Positives = 144/405 (35%), Gaps = 61/405 (15%) Query: 283 SPEDLERGAAPVSAEAAAQGSI-FLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGG 341 SP++ + SA A+++G++ +LA + P S + ++G + N Sbjct: 766 SPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGN-- 823 Query: 342 PVIINGLALGEASSL--GPLLLTGGGGAP-----PPQPSPQGASETKTSLVLDPQTGEVR 394 + + ++ EAS L L G +P P PSP+GA L P+ V Sbjct: 824 --LSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKG--VT 879 Query: 395 LEEAQSEAPETKGAQVAAPGPALGEEVLGP-LAQVVPGPPTAATFPLPPGPVPAVAAPQV 453 L ++ P GPA P L+ P A P P G +PA +P+ Sbjct: 880 LPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKG-IPASPSPKG 938 Query: 454 VPLSPP--PGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAA 511 P P P P G P +P P+ PT T P G GP +P A Sbjct: 939 APTPPAATPPSPKG-GPATPS---PKWAPTPPAATPPSPKG-------GPATPSPKGAPT 987 Query: 512 GPANVHLINSGVGVTALQLPSATAPGNFLLANPVS--GSPIVTGVAVQQGKIILTATFPT 569 PA G T + T P P S GSP T +G A P Sbjct: 988 PPAATPPSPKGGPATPSPKGAPTPPA----VTPPSPKGSPAAT--PFPKGASTPPAATPP 1041 Query: 570 SMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATT 629 S S P P A P P + P+GG PA P +L PPAA Sbjct: 1042 SPKGSPAATPLPKGA-PTTPAATLPSPKGG------PATP------SLKGAPTPPAATPP 1088 Query: 630 SSTSLPFSPD------SPGLLPNFP-----APPPEGLMLSPAAVP 663 S P +P P P P PP +G +PAA P Sbjct: 1089 SPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATP 1133 Score = 55.5 bits (132), Expect = 2e-07 Identities = 100/432 (23%), Positives = 146/432 (33%), Gaps = 63/432 (14%) Query: 310 GPPAPCPASSSILVNGSFLA----ASGSPAVLL----NGGPVIINGLALGEASSLGPLLL 361 G P P PA++ + G + +PAV+ GGP + P Sbjct: 1262 GAPTP-PAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSP 1320 Query: 362 TGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEV 421 G G PPP+ +P + T S P + P T ++ PA Sbjct: 1321 KGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATT--PSSKGGPTTPSSKEGPTPPAATPSH 1378 Query: 422 LGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPT 481 G A P P P P G +P V+PLSP +P +P+ P+ Sbjct: 1379 KGGPAMTPPSPKRGPAIPSPKGDP---TSPAVIPLSPKK------APATPVTREGAATPS 1429 Query: 482 SQVVTLPQAVGPLQLLAA--------GPGSPVKVAAAAGPANVHLINSGVGVTALQLPSA 533 +T P AV P+ L A GP +P PA V + Q+ ++ Sbjct: 1430 KGDLT-PPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPA-VTPPSPKEPPAPKQVATS 1487 Query: 534 TAPGNFLLANPVSGSPIVTGVAVQQGKIILTATF-------PTSMLVSQVLPPAPGLALP 586 ++P G+P + V K + PT+ L+S+ P Sbjct: 1488 SSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPAT------ 1541 Query: 587 LKPETAISVPEGGLPVAP-SPALP---EAHALGTLSAQQPPPAAATTSSTSLPFSPDSPG 642 L P+ A+ P +P +PA+P EA A + PPA ++ P SP Sbjct: 1542 LAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAP-SPKELL 1600 Query: 643 LLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPE 702 + P +P P+ PA P EKG T AP P P Sbjct: 1601 IPPAVTSPSPKEAPTPPAVTPP---------------SPEKGPATPAPKGTPTSPPVTPS 1645 Query: 703 GLLLGATAGGEV 714 L T+ V Sbjct: 1646 SLKDSPTSPASV 1657 Score = 52.0 bits (123), Expect = 2e-06 Identities = 66/253 (26%), Positives = 98/253 (38%), Gaps = 45/253 (17%) Query: 426 AQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGL--------SPTSPLLNLPQ 477 A P P T A+ PL P P ++ +PL P PT L SP + L P Sbjct: 64 ASPFPSPSTIASTPLEV-PFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPM 122 Query: 478 VVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAA-----AAGPANVHLINSGVGVTALQLPS 532 + PT + P + PL L+A P S K +A P +V + SG +T Sbjct: 123 IAPTLKGT--PSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVIT------ 174 Query: 533 ATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETA 592 L+ P++ S T + +++ S PP +P T Sbjct: 175 --------LSAPIAPSEPKTNLNKVPSEVVPNPKGTPS-------PPCIVSTVPYHCVTP 219 Query: 593 ISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLP-NFPAPP 651 ++ + G+ +LP+ TL+ P T SS + SP +PG L P P Sbjct: 220 MASIQSGVA-----SLPQTTPTTTLAIASPQVKDTTISSVLI--SPQNPGSLSLKGPVSP 272 Query: 652 PEGLMLSPAAVPV 664 P L LS ++PV Sbjct: 273 PAALSLSTQSLPV 285 Score = 52.0 bits (123), Expect = 2e-06 Identities = 94/358 (26%), Positives = 121/358 (33%), Gaps = 49/358 (13%) Query: 311 PPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPP 370 PPA P + + S +A A P +G A ASS G L Sbjct: 740 PPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSG-ASATASSKGTLTYLADS----- 793 Query: 371 QPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVP 430 PSP G S + PQT ++ S P+T +++P + L + Sbjct: 794 -PSPLGVS-------VSPQTKRPPTKKG-SAGPDTPIGNLSSPVSPVEASFLPENSLSFQ 844 Query: 431 GP---PTAATFPLPPGPVPAVAAPQVVPLSPPP-GYPTGLSPTSPLLNLPQVVPTSQVVT 486 G P P PP P A V PLSP P +PT ++NLP P T Sbjct: 845 GSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLP--FPKEGPAT 902 Query: 487 LPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVS 546 P L+ SP K A P + S G A P+AT P P + Sbjct: 903 PAPKQAPA--LSMTSSSPKKARATPAPKGIPASPSPKG--APTPPAATPPSP--KGGPAT 956 Query: 547 GSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSP 606 SP A P S P G P P P+GG P Sbjct: 957 PSPKWAPTP--------PAATPPSPKGGPATPSPKGAPTP--PAATPPSPKGG------P 1000 Query: 607 ALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPV 664 A P T A PP + ++T P +P P P P+G SPAA P+ Sbjct: 1001 ATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTP---PAATPPSPKG---SPAATPL 1052 Score = 47.8 bits (112), Expect = 4e-05 Identities = 104/444 (23%), Positives = 140/444 (31%), Gaps = 69/444 (15%) Query: 311 PPAPCPAS-----SSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGG 365 PP P P SS+LV + L G P + G + P +L Sbjct: 507 PPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAP--FSPAQAGLTTKKDPTVLPLVQ 564 Query: 366 GAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQ------------SEAPETKGAQVAAP 413 AP PS Q S + + L P+ + + S A V Sbjct: 565 AAPKNSPSFQSTSSSP-EIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKT 623 Query: 414 GPALGEEVLGPLAQVVPGPPTAATFPL----PPGPVPAVA---APQVVPLSP-------- 458 G + GPL + PT A FPL P G P A + SP Sbjct: 624 DSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSL 683 Query: 459 -PPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQ-AVGPLQLLAAGPGSPVKVAA-----AA 511 P +P + L +P V PQ PL L P P V + A Sbjct: 684 APKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAG 743 Query: 512 GPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSM 571 P ++ G+ T+ P A++P P S + A +G + A P+ + Sbjct: 744 TPPGTKKVD-GISHTSALAPVASSPKEC----PTEDSG-ASATASSKGTLTYLADSPSPL 797 Query: 572 LVSQVLP----------------PAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALG 615 VS V P P L+ P+ P A +PE L S P Sbjct: 798 GVS-VSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPAT---- 852 Query: 616 TLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGT 675 T S P P A T S P SP L P P + P P A + A + Sbjct: 853 THSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALS 912 Query: 676 EGLLEAEKGLGTQAPHTVLRLPDP 699 +K T AP + P P Sbjct: 913 MTSSSPKKARATPAPKGIPASPSP 936 Score = 46.2 bits (108), Expect = 1e-04 Identities = 77/317 (24%), Positives = 114/317 (35%), Gaps = 56/317 (17%) Query: 348 LALGEASSLGPLLLTGGGGAPPP-QPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETK 406 L + A S+ L G PPP P+PQ + L A +P Sbjct: 26 LPMSSALSVTAALGQPGPTLPPPCSPAPQ----------------QCPLSAANQASPFPS 69 Query: 407 GAQVAA-----PGPALGEEVLGPLAQVVPGP---PTAATFPLPPGPVPAVAAPQVVPLSP 458 + +A+ P P PL P P P+ P + A+A+P + P Sbjct: 70 PSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAAL-ALASPMIAPTLK 128 Query: 459 PPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHL 518 G P+ +P + + P V S P + A GS + ++A P+ Sbjct: 129 --GTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKT 186 Query: 519 INSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLP 578 + V + P T P + + V + ++Q G L T PT+ L Sbjct: 187 NLNKVPSEVVPNPKGT-PSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTL------ 239 Query: 579 PAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQP--PPAAATTSSTSLPF 636 +A P +T IS V SP P G+LS + P PPAA + S+ SLP Sbjct: 240 ---AIASPQVKDTTIS------SVLISPQNP-----GSLSLKGPVSPPAALSLSTQSLPV 285 Query: 637 SPDS-----PGLLPNFP 648 S P P+FP Sbjct: 286 VTSSQKTAGPNTPPDFP 302 Score = 40.4 bits (93), Expect = 0.006 Identities = 95/401 (23%), Positives = 146/401 (36%), Gaps = 50/401 (12%) Query: 283 SPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGP 342 SP+ + + V GS+ L G P PA+ S+ + S GP Sbjct: 243 SPQVKDTTISSVLISPQNPGSLSLKG---PVSPPAALSLSTQSLPVVTSSQKTA----GP 295 Query: 343 VIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEA 402 + S L PL + G S Q +T S + DP + ++ + + A Sbjct: 296 NTPPDFPISLGSHLAPLHQSSFG-------SVQLLGQTGPSALSDPTVKTISVDHSSTGA 348 Query: 403 PETKGAQVAAPGPALGEEVLGPLA-------QVVPGPPTAATFPLPPGPVPAVAAPQVVP 455 V P P+ E V +A V GP T ++ P VA Sbjct: 349 SYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATS--FS 406 Query: 456 LSPPPGYPTGLSPTSPLLNLPQV--VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGP 513 LSP SP + + P V +P S V T P V +AA P + +VA P Sbjct: 407 LSPTTSLILKSSPNATY-HYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSP 465 Query: 514 ANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLV 573 ++SG + T+P ++A PV+ T VA +I ++ P + Sbjct: 466 P----MSSG----PISNIEPTSPAALVMA-PVAPKEPSTQVATTL-RIPVSPPLPDPEDL 515 Query: 574 SQVLPPAPGLALPLKPETAISVPEG--GLPVAPSPA------LPEAHALGTLSAQQPPPA 625 LP + + P + + +VP G P +P+ A P L + + P Sbjct: 516 KN-LPSSVLVKFPTQKDLQ-TVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSF 573 Query: 626 AATTSSTSLPFSPDS----PGLLPNFPAPPPEGLMLSPAAV 662 +T+SS +P SP++ L P P M SP V Sbjct: 574 QSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGV 614 Score = 37.7 bits (86), Expect = 0.039 Identities = 40/141 (28%), Positives = 59/141 (41%), Gaps = 25/141 (17%) Query: 568 PTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAA 627 P + VLP + L++ A+ P LP SPA P+ L + P P+ + Sbjct: 17 PQPQAETAVLPMSSALSVT----AALGQPGPTLPPPCSPA-PQQCPLSAANQASPFPSPS 71 Query: 628 TTSSTSL--PF-------------SPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELS 672 T +ST L PF +P++P LPN PP +SPAA+ + S + + Sbjct: 72 TIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPP-----ISPAALALASPMIAPT 126 Query: 673 AGTEGLLEAEKGLGTQAPHTV 693 A L APH+V Sbjct: 127 LKGTPSSSAPLALVALAPHSV 147 Score = 37.7 bits (86), Expect = 0.039 Identities = 66/268 (24%), Positives = 93/268 (34%), Gaps = 34/268 (12%) Query: 265 PCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA---QGSIFL-AGTGPPA------- 313 P G PT+ + S +D A V+ + A Q S L A GP A Sbjct: 1628 PATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVA 1687 Query: 314 PCPASSSILV----NGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLL-------- 361 P P S+ I+ G S + + + P NG + G S++ P L Sbjct: 1688 PAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNG-SKGPLSTVAPAPLLPVQKDSS 1746 Query: 362 --TGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSE----APETKGAQVAAPGP 415 G A P E+K S L E L + +S AP + AP P Sbjct: 1747 KTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSP 1806 Query: 416 ALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNL 475 L P Q +P P P P+ +++PL PP G+ S L+N+ Sbjct: 1807 V---PTLPPKQQFLPSSP-GLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNM 1862 Query: 476 PQVVPTSQVVTLPQAVGPLQLLAAGPGS 503 P V P A P+ G G+ Sbjct: 1863 PTPKSAGIPVPTPSAKQPVTKNNKGSGT 1890 >gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens] Length = 2217 Score = 66.2 bits (160), Expect = 1e-10 Identities = 128/471 (27%), Positives = 176/471 (37%), Gaps = 111/471 (23%) Query: 280 SSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPAS---SSILVNGSFLAASGSPAV 336 +S S D +G+ S ++Q S+ L AP PA S + G L S P++ Sbjct: 611 ASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQS-LPSL 669 Query: 337 LLNGGPVIINGLALGE-----------------ASSLGPLLL-------TGGGG-APPPQ 371 P GL +G A S P+L TG G APP Q Sbjct: 670 GAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQ 729 Query: 372 PSPQGASETKTSLVLDPQTGEVRLEEAQSEAPE--TKGAQVAAPGPA----LGEEVLGPL 425 P A T VL PQ V L+ P +QV AP + + L PL Sbjct: 730 QPPPLAQPTPLPQVLAPQP-VVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPL 788 Query: 426 AQV-------------------------VPGPPTAATFPLPPGP-------VPAVAAP-- 451 AQV +P PTA P+PP +P++AAP Sbjct: 789 AQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLP 848 Query: 452 --------QVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQL---LAAG 500 Q V L PPG P + + + N P +P V P V L + +A Sbjct: 849 PASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVA--PPGVAALSIHSAVAQL 906 Query: 501 PGSPV------KVAAAAGPANVHLINSGVGVTALQL---PSATAPGNFLLANP--VSGSP 549 PG PV ++A P + H + T Q P T P +L + P Sbjct: 907 PGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQP 966 Query: 550 IVTGVAVQQGKIILTATFPTSMLVSQ-VLPPAPGLALPLKPETAIS-VPEGGLPVA-PSP 606 ++ + + +L P ML Q VLPP P ALP++PE +PE P A P Sbjct: 967 VLPPQPTRPPQPVLP---PQPMLPPQPVLPPQP--ALPVRPEPLQPHLPEQAAPAATPGS 1021 Query: 607 AL----PEAHALGTLSAQQP----PPAAATTSSTSLPFSPDSPGLLPNFPA 649 + P +A+ ++AQ P PPAA + P +P LLP FP+ Sbjct: 1022 QILLGHPAPYAVD-VAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPS 1071 Score = 65.5 bits (158), Expect = 2e-10 Identities = 119/410 (29%), Positives = 155/410 (37%), Gaps = 96/410 (23%) Query: 277 EDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSS--ILVNGSFLAASGSP 334 E E + + L P SA + A S F +G G + SS ++ GS A+ SP Sbjct: 588 EPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSP 647 Query: 335 AVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQ-GASETKTSLVLDPQTGEV 393 A + PV S GP+L PQ P GA + T+ Sbjct: 648 AQCVCSPPV-----------SEGPVL---------PQSLPSLGAYQQPTA---------- 677 Query: 394 RLEEAQSEAPETKGAQVAAPG--PALGEEVLGP---LAQVVPGP----PTAATFPLPPG- 443 AP V AP P+L + P A V+P P PT P PPG Sbjct: 678 --------APGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQ 729 Query: 444 ---------PVPAVAAPQ-VVPLSP-PPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVG 492 P+P V APQ VVPL P PP P L+P S + Q+ P + +PQA Sbjct: 730 QPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKP----LQMPQA-- 783 Query: 493 PLQLLAAGPGS--PVKVAAAAGP-ANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSP 549 PLQ LA P P+ V P A + G+ LP+AT P + P SP Sbjct: 784 PLQPLAQVPPQMPPIPVVPPITPLAGI----DGLPPALPDLPTATVPP---VPPPQYFSP 836 Query: 550 IVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALP 609 V I+ + P LPPA ALPL+ P L + +P Sbjct: 837 AV---------ILPSLAAP--------LPPASP-ALPLQAVKLPHPPGAPLAMPCRTIVP 878 Query: 610 EAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSP 659 A A L A PP AA + +++ P P FP P + SP Sbjct: 879 NAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSP 928 Score = 52.8 bits (125), Expect = 1e-06 Identities = 85/341 (24%), Positives = 112/341 (32%), Gaps = 64/341 (18%) Query: 342 PVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASET----KTSLVLDPQTGEVRLEE 397 PV+ L L P L PP P PQ S + L P + + L+ Sbjct: 799 PVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQA 858 Query: 398 AQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP-------LPPGPVPAVAA 450 + P GA +A P + + + PP A LP PV A Sbjct: 859 VK--LPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAF 916 Query: 451 PQVVPLSPPPGY-----------------------PTGLSPTSPLLNLPQVVPTSQVVTL 487 PQ+ P PP P + P P L PQ V Q Sbjct: 917 PQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLP-PQPVLPPQPTRP 975 Query: 488 PQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSG 547 PQ V P Q + P PV A P + + A P+AT LL +P Sbjct: 976 PQPVLPPQPML--PPQPVLPPQPALPVRPEPLQPHLPEQAA--PAATPGSQILLGHP--- 1028 Query: 548 SPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPA 607 +P VA Q + T P + ++S PP P + LP PE P Sbjct: 1029 APYAVDVAAQ----VPTVPVPPAAVLS---PPLPEVLLPAAPELL-------------PQ 1068 Query: 608 LPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFP 648 P + A + S Q P AT + P P PG+ P Sbjct: 1069 FPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCP 1109 Score = 43.1 bits (100), Expect = 0.001 Identities = 78/331 (23%), Positives = 110/331 (33%), Gaps = 64/331 (19%) Query: 405 TKGAQVAAPGPALGEE-------------------------------------------- 420 T AQ PGP EE Sbjct: 576 TYHAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSV 635 Query: 421 VLGPLAQVVPGP-PTAATFPLPPGPVPAVAAPQVVPLSPP---PGYPTGLSPTSPL-LNL 475 +LG LA P P + P+ GPV + P + P PG P G P +L Sbjct: 636 MLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSL 695 Query: 476 PQVVPTSQVVTLPQAVGPLQLLAAGPGSPV----KVAAAAGPANVHLINSGVGVTALQLP 531 Q P + P P + GPG P + A P + + + V LQ Sbjct: 696 QQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPV 755 Query: 532 SATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLA-LPLKPE 590 P A+ V + + + Q + A P M V+PP LA + P Sbjct: 756 PPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPP 815 Query: 591 TAISVPEGGLPVAPSPA-LPEAHALGTLSAQQPPPA-AATTSSTSLPFSPDSP------G 642 +P +P P P A L +L+A PP + A + LP P +P Sbjct: 816 ALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRT 875 Query: 643 LLPNFPAPPPEGLMLSP--AAVPVWSAGLEL 671 ++PN PA P + P AA+ + SA +L Sbjct: 876 IVPNAPATIPLLAVAPPGVAALSIHSAVAQL 906 Score = 41.2 bits (95), Expect = 0.004 Identities = 43/159 (27%), Positives = 53/159 (33%), Gaps = 22/159 (13%) Query: 360 LLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALG- 418 LL+ G + PP P + + + PQ G E +Q PG G Sbjct: 1367 LLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGL 1426 Query: 419 ---EEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVV----------PLSPPPGYPTG 465 E PLA+ P A PL G P AP+ PL PP P Sbjct: 1427 TSELETSQPLAETHEAP--LAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEP-- 1482 Query: 466 LSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSP 504 SP PQ LP AVG + L + SP Sbjct: 1483 ----SPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSP 1517 Score = 38.5 bits (88), Expect = 0.023 Identities = 50/203 (24%), Positives = 70/203 (34%), Gaps = 34/203 (16%) Query: 452 QVVPLSPPPGYPTGLSPTSPLLN-LPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAA 510 Q P +PP P L+P+SP + LPQ T+P+ A GPG+P Sbjct: 1370 QAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQ----- 1424 Query: 511 AGPANVHLINSGVGVTA-LQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPT 569 G+T+ L+ A + P++ P+V G+A +T Sbjct: 1425 -------------GLTSELETSQPLAETH---EAPLAVQPLVVGLAPCTPAPEAASTRDA 1468 Query: 570 SMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATT 629 S + PPAP + P + P G P PA A +L T PP Sbjct: 1469 SAPREPLPPPAPEPS----PHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVP 1524 Query: 630 SSTSLPFSPDSPGLLPNFPAPPP 652 D G PPP Sbjct: 1525 PQPPSALESDGEG-------PPP 1540 Score = 32.3 bits (72), Expect = 1.6 Identities = 43/143 (30%), Positives = 51/143 (35%), Gaps = 13/143 (9%) Query: 529 QLPSATAPGNFLLANPVS---GSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLAL 585 QL S P N A P SP VT + Q G T+T P + PG Sbjct: 1366 QLLSQAGPSNPPGAPPAPLAPSSPPVTALP-QDGAAPATSTMPEPASGTASQAGGPGTPQ 1424 Query: 586 PLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLP---FSPDSPG 642 L E S P AP P L + P P AA+T S P P +P Sbjct: 1425 GLTSELETSQPLAETHEAPLAVQPLVVGLAPCT---PAPEAASTRDASAPREPLPPPAPE 1481 Query: 643 LLPNFPAPPP---EGLMLSPAAV 662 P+ P P + L PAAV Sbjct: 1482 PSPHSGTPQPALGQPAPLLPAAV 1504 Score = 32.0 bits (71), Expect = 2.1 Identities = 37/135 (27%), Positives = 51/135 (37%), Gaps = 30/135 (22%) Query: 369 PPQPS--PQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426 PPQP PQ + +L + P+ + L E Q+ T G+Q+ PA + Sbjct: 981 PPQPMLPPQPVLPPQPALPVRPEPLQPHLPE-QAAPAATPGSQILLGHPAPYAVDVAAQV 1039 Query: 427 QVVPGPPTAATFP------LPPGP-------------------VPAVAAPQVVPLSPP-P 460 VP PP A P LP P VP A + P +PP P Sbjct: 1040 PTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLP 1099 Query: 461 GYPTGLSPTSPLLNL 475 G P G++ P + L Sbjct: 1100 GGP-GIASPCPTVQL 1113 Score = 30.4 bits (67), Expect = 6.2 Identities = 17/49 (34%), Positives = 21/49 (42%) Query: 48 AAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCE 96 A G AA A A PG PG+P +A EP P+ +A E Sbjct: 86 AERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAAAVE 134 >gi|110832843 TBP-associated factor 4 [Homo sapiens] Length = 1085 Score = 65.5 bits (158), Expect = 2e-10 Identities = 95/371 (25%), Positives = 127/371 (34%), Gaps = 37/371 (9%) Query: 331 SGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQT 390 SGSPA GP A G A P GG P +P P P Sbjct: 64 SGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPA 123 Query: 391 GEVRLE---EAQSEAPETKGAQVAA-PGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVP 446 ++R A S AP A VAA P PA P P P A PGP P Sbjct: 124 AKLRPPPEGSAGSCAPVPAAAAVAAGPEPA-------PAGPAKPAGPAALAARAGPGPGP 176 Query: 447 AVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVK 506 P P P PG P G L ++ + A + L+ GP + + Sbjct: 177 ---GPGPGP-GPGPGKPAGPGAAQTLNGSAALLNSHHA-----AAPAVSLVNNGPAALLP 227 Query: 507 VAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTAT 566 + A P V VG A P+A +P P + +P A Sbjct: 228 LPKPAAPGTVIQTPPFVGAAAPPAPAAPSP-------PAAPAPAAPAAAPPP-----PPP 275 Query: 567 FPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAA 626 P ++ P P A P P A + G AP+PA P A +S Q P AA Sbjct: 276 APATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPA-PAAGGPAGVSGQPGPGAA 334 Query: 627 ATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLG 686 A + + +SP + A PP L+ + +A + + +G L + + Sbjct: 335 AAAPAPGV--KAESPKRV--VQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVP 390 Query: 687 TQAPHTVLRLP 697 AP T LP Sbjct: 391 PPAPGTPTGLP 401 Score = 64.7 bits (156), Expect = 3e-10 Identities = 103/424 (24%), Positives = 139/424 (32%), Gaps = 70/424 (16%) Query: 259 GAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVS-AEAAAQGSIFLAGTGPPA---- 313 GA G P + ++G P E + G P + + + AG PPA Sbjct: 69 GAAGAGPA-APAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLR 127 Query: 314 PCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLT-------GGGG 366 P P S+ GS + AV P G A GP L G G Sbjct: 128 PPPEGSA----GSCAPVPAAAAVAAGPEPA-----PAGPAKPAGPAALAARAGPGPGPGP 178 Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAA----PGPALGEEVL 422 P P P P + + L+ + A + A AA P PA V+ Sbjct: 179 GPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVI 238 Query: 423 ---------GPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLL 473 P A P PP AA P P P P L+ PPG+P G +P + Sbjct: 239 QTPPFVGAAAPPAPAAPSPP-AAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAV 297 Query: 474 NLPQVVPTSQVVTLPQAVGPLQLLAAGP----GSPVKVAAAAGPANVHLINSGVGVTALQ 529 P A P A GP G P AAAA PA GV + + Sbjct: 298 PPPAAAQNGGSAGAAPAPAP---AAGGPAGVSGQPGPGAAAAAPA------PGVKAESPK 348 Query: 530 LPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKP 589 AP P + + +G A +++ T ++ P+P P P Sbjct: 349 RVVQAAP-------PAAQTLAASGPASTAASMVIGPTMQGAL-------PSPAAVPPPAP 394 Query: 590 ETAISVPEG--GLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNF 647 T +P+G G P A G + P T + LP P +P + NF Sbjct: 395 GTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTP-----TVLAPRLPQPPQNPTNIQNF 449 Query: 648 PAPP 651 PP Sbjct: 450 QLPP 453 Score = 60.8 bits (146), Expect = 4e-09 Identities = 103/424 (24%), Positives = 149/424 (35%), Gaps = 53/424 (12%) Query: 257 RTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP----P 312 R G G G P G + + + L AA +++ AA ++ L GP P Sbjct: 169 RAGPGPG-PGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLP 227 Query: 313 APCPAS-SSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGP-----LLLTGGGG 366 P PA+ +++ F+ A+ PA P A A P L G Sbjct: 228 LPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHP 287 Query: 367 APPPQPSPQ----GASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVL 422 A PP +P A++ S P A GA AAP P + E Sbjct: 288 AGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESP 347 Query: 423 GPLAQVVP---------GPP-TAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGL------ 466 + Q P GP TAA+ + P A+ +P VP P PG PTGL Sbjct: 348 KRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVP-PPAPGTPTGLPKGAAG 406 Query: 467 SPTSPLLNLPQVVPTSQVVTL-PQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVG- 524 + T L P + TL P + P L P +P + P + L+ S G Sbjct: 407 AVTQSLSRTPTATTSGIRATLTPTVLAPR--LPQPPQNPTNIQNFQLPPGMVLVRSENGQ 464 Query: 525 --------VTALQLPSATAPGNFLL---ANPVSGSPIVTGVAVQQGKIILTATFPTSMLV 573 + +Q + P + A P S P+ G I+ + ++ Sbjct: 465 LLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTII 524 Query: 574 SQVLPPA----PGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATT 629 QV P L P + GG A + +L A A+ T + Q+ P A TT Sbjct: 525 KQVSQAQTTVQPSATLQRSPGVQPQLVLGG--AAQTASLGTATAVQTGTPQRTVPGATTT 582 Query: 630 SSTS 633 SS + Sbjct: 583 SSAA 586 Score = 47.0 bits (110), Expect = 6e-05 Identities = 80/283 (28%), Positives = 100/283 (35%), Gaps = 67/283 (23%) Query: 402 APETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPG 461 AP T + AA G ALG V V G P A P P A AP P PP G Sbjct: 44 APRTPEVRAAAAG-ALGNHV-------VSGSPAGAAGAGPAAP--AEGAPGAAPEPPPAG 93 Query: 462 Y----------PTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAA- 510 P SP PL+ P +++ P+ +AG +PV AAA Sbjct: 94 RARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEG-------SAGSCAPVPAAAAV 146 Query: 511 --------AGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKII 562 AGPA +G A + PG P G P G A Sbjct: 147 AAGPEPAPAGPAKP----AGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAA------- 195 Query: 563 LTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQP 622 ++ S L + A P A+S+ G P A P LP+ A GT+ P Sbjct: 196 ------QTLNGSAALLNSHHAAAP-----AVSLVNNG-PAALLP-LPKPAAPGTVIQTPP 242 Query: 623 ------PPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSP 659 PPA A S + P +P +P P P P P L P Sbjct: 243 FVGAAAPPAPAAPSPPAAP-APAAPAAAPPPPPPAPATLARPP 284 Score = 35.4 bits (80), Expect = 0.19 Identities = 32/103 (31%), Positives = 37/103 (35%), Gaps = 5/103 (4%) Query: 5 PAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGP 64 P E SAG A A AA AA E A AA AG G G GP Sbjct: 129 PPEGSAGSCAPVPAAAAVAAGPEPAPAG----PAKPAGPAALAARAGPGPGPGPGPGPGP 184 Query: 65 GSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRL 107 G PG P P A + + + A +L+ G A L Sbjct: 185 G-PGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALL 226 Score = 32.3 bits (72), Expect = 1.6 Identities = 41/136 (30%), Positives = 49/136 (36%), Gaps = 25/136 (18%) Query: 2 ATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGA 61 A PA P+A P A A A A AAA G AGAA A A Sbjct: 260 APAPAAPAAAPPPPPPAPATLARPPGHPAGPPT---AAPAVPPPAAAQNGGSAGAAPAPA 316 Query: 62 EGPGSP----GVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPA 117 G P G PG AA+ P SP++V +QA A P A Sbjct: 317 PAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRV-------VQA-----------APPAA 358 Query: 118 ERLRGSDPVLRARALV 133 + L S P A ++V Sbjct: 359 QTLAASGPASTAASMV 374 Score = 32.0 bits (71), Expect = 2.1 Identities = 35/117 (29%), Positives = 45/117 (38%), Gaps = 7/117 (5%) Query: 22 AAATEEEEEEARQLLQTLQAAEGEAA--AAAGAGAGAAAAGAEGP--GSPGVPGSPPEAA 77 AA+ A + + AA G +G+ AGAA AG P G+PG PP A Sbjct: 34 AASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAG 93 Query: 78 SEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVA 134 P G L+ AG A ++ PP E GS + A A VA Sbjct: 94 RARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKL---RPPPEGSAGSCAPVPAAAAVA 147 >gi|160707881 formin 2 [Homo sapiens] Length = 1722 Score = 64.3 bits (155), Expect = 4e-10 Identities = 102/377 (27%), Positives = 131/377 (34%), Gaps = 68/377 (18%) Query: 358 PLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPAL 417 PL G G PPP P P A L P G + L P GA + P P Sbjct: 933 PLPPLPGAGIPPPPPLPGAAIPPPPPL---PGAG-IPL------PPPLPGAGIPPPPPLP 982 Query: 418 GEEVLGPL----AQVVPGPPTAATFPLPPGPVPAVAAPQVVPL-----SPPPGYP-TGLS 467 G + P A + P PP PP P+P P PL PPP P G+ Sbjct: 983 GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1042 Query: 468 PTSPL----LNLPQVVPTSQVVTLPQAVG-----PLQLLAAGPGSPVKVAAAAGPANVHL 518 P PL + P +P + + P G P L AG P + A P L Sbjct: 1043 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1102 Query: 519 INSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQV-- 576 GVG+ P PG + P + G + + A P + +V Sbjct: 1103 --PGVGIP----PPPPLPG-----AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGI 1151 Query: 577 --LPPAPGLALPLKPETAISVPEGGL---PVAPSPALPEAHALGTLSAQQPPPAAATTSS 631 PP PG +P P +P G+ P P +P L + PPP Sbjct: 1152 PPPPPLPGAGIPPPP----PLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP----LPG 1203 Query: 632 TSLPFSPDSPGL-LPNFPAP--PPEGLML-SPAAVPVWSAGLELSAGTEGLLEAEKGLGT 687 +P P PG+ +P PAP PP G + P +PV L G+ L Sbjct: 1204 AGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL--------- 1254 Query: 688 QAPHTVLRLPDPDPEGL 704 P LP P P GL Sbjct: 1255 PTPQVCGFLPPPLPSGL 1271 Score = 61.2 bits (147), Expect = 3e-09 Identities = 96/369 (26%), Positives = 124/369 (33%), Gaps = 53/369 (14%) Query: 306 LAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGG 365 L G G P P P + + L +G P G I L A P L G G Sbjct: 937 LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996 Query: 366 GAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPL 425 PPP P P L P G P GA + P P G + P Sbjct: 997 -IPPPPPLPGAGIPPPPPL---PGAGI-------PPPPPLPGAGIPPPPPLPGAGIPPPP 1045 Query: 426 ----AQVVPGPPTAATFPLPPGPVPAVAAPQVVPLS-----PPPGYP-TGLSPTSPLLNL 475 A + P PP PP P+P P PL PPP P G+ P PL + Sbjct: 1046 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGV 1105 Query: 476 ----PQVVPTSQVVTLPQAVG-----PLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVT 526 P +P + + P G P L AG P + P L +G+ Sbjct: 1106 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165 Query: 527 ALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALP 586 + P L + P + GV + + A P PP PG+ +P Sbjct: 1166 PPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPP-------PPLPGMGIP 1218 Query: 587 LKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPN 646 P + P G+P P P LP + PP S++LP +P G L Sbjct: 1219 PAPAPPLPPPGTGIP--PPPLLPVS----------GPPLLPQVGSSTLP-TPQVCGFL-- 1263 Query: 647 FPAPPPEGL 655 P P P GL Sbjct: 1264 -PPPLPSGL 1271 Score = 55.8 bits (133), Expect = 1e-07 Identities = 85/350 (24%), Positives = 117/350 (33%), Gaps = 65/350 (18%) Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426 +PPP P + +S ++ P + P + P P G E+L P Sbjct: 857 SPPPLPCTESSSSMPGLGMVPPPPPPL----PGMTVPTLPSTAIPQPPPLQGTEMLPP-- 910 Query: 427 QVVPGPPTAATFPLPPGPVPAVAAPQVVPLS-----PPPGYP-TGLSPTSPL----LNLP 476 P PP PP P+P + PL PPP P + P PL + LP Sbjct: 911 ---PPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 967 Query: 477 QVVPTSQVVTLPQAVG-----PLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLP 531 +P + + P G P L AG P + A P L +G+ P Sbjct: 968 PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------P 1021 Query: 532 SATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPET 591 PG + P + G + + A P PP PG +P P Sbjct: 1022 PPPLPG-----AGIPPPPPLPGAGIPPPPPLPGAGIPPP-------PPLPGAGIPPPP-- 1067 Query: 592 AISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPP 651 +P G+P P P LP A PPP +P P PG+ P PP Sbjct: 1068 --PLPGAGIP--PPPPLPGA------GIPPPPP----LPGAGIPPPPPLPGV--GIPPPP 1111 Query: 652 PEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDP 701 P P P+ AG+ G G+ P + +P P P Sbjct: 1112 PLPGAGIPPPPPLPGAGIPPPPPLPG-----AGIPPPPPLPRVGIPPPPP 1156 Score = 33.9 bits (76), Expect = 0.56 Identities = 64/252 (25%), Positives = 89/252 (35%), Gaps = 37/252 (14%) Query: 485 VTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANP 544 VT P GP + G V AAG + +SG SAT + L + Sbjct: 141 VTGPGGPGPAEARVGGRPIAEDVETAAGAQDGQRTSSGSDTDIYSFHSATEQEDLL--SD 198 Query: 545 VSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISV------PEG 598 + + + QQ ++ L L P AP A+ +P + + P G Sbjct: 199 IQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSG 258 Query: 599 GLPVAP-SP----------ALPEAHALGTLSAQQPPP------AAATTSSTSLPFSPDSP 641 G AP SP LPE+ A QQPP + A + + P + DSP Sbjct: 259 GAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSP 318 Query: 642 GLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLE-AEKG---------LGTQAPH 691 FP P G A PV AG G E E A +G +G AP Sbjct: 319 SSTA-FPF-PEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQ 376 Query: 692 TVLRLPDPDPEG 703 + P+ + +G Sbjct: 377 RLGEEPEEEAQG 388 Score = 32.7 bits (73), Expect = 1.2 Identities = 33/105 (31%), Positives = 45/105 (42%), Gaps = 14/105 (13%) Query: 1 MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTL-----QAAEGEAAAAA---GA 52 +A P EP P+ GG V+ A + + A+ + +A GE AA A GA Sbjct: 283 LAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGA 342 Query: 53 G----AGAAAAGAEGP-GSPGVPGSPPEAASEPPTGLRFSPEQVA 92 G G A + P GSPG + PE + P L PE+ A Sbjct: 343 GDTDEEGEEDAFEDAPRGSPGEEWA-PEVGEDAPQRLGEEPEEEA 386 Score = 30.4 bits (67), Expect = 6.2 Identities = 66/269 (24%), Positives = 96/269 (35%), Gaps = 52/269 (19%) Query: 259 GAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP--CP 316 G GGA E+ G+P TE S + DL A E PP+P P Sbjct: 255 GPSGGA---GEAPGSPDTEQALS-ALSDLPESLAAEPREPQQ----------PPSPGGLP 300 Query: 317 ASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQG 376 S + + + AA SP+ S+ P G G P +G Sbjct: 301 VSEAPSLPAAQPAAKDSPS------------------STAFPFPEAGPGEEAAGAPV-RG 341 Query: 377 ASETKTSLVLDPQTGEVRLEEAQSEAPETKGA-QVAAPGPA-LGEEVLGPLAQVVPGPPT 434 A +T D + E E+A +P + A +V P LGEE + GP Sbjct: 342 AGDT------DEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEP----EEEAQGPDA 391 Query: 435 AATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPL 494 A LP P P+ + PL P + T+ L+ P P+ P+ + Sbjct: 392 PAAASLPGSPAPSQRCFKPYPLIT----PCYIKTTTRQLSSPNHSPSQSPNQSPR-IKRR 446 Query: 495 QLLAAGPGSPVKVAAAAGPANVHLINSGV 523 + GS +A+ A PA H + G+ Sbjct: 447 PEPSLSRGSRTALASVAAPAKKHRADGGL 475 >gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens] Length = 1003 Score = 63.2 bits (152), Expect = 9e-10 Identities = 116/429 (27%), Positives = 143/429 (33%), Gaps = 93/429 (21%) Query: 263 GAPCKSESDGNPTTEDESSRSP-EDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSI 321 GAP + P +SP E L GA P G G P P P Sbjct: 474 GAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAG-----GEAFPFPSPEQGLA 528 Query: 322 LVNGSFLAASGS-PAVLLNGGPV---IINGLALGEASSLGPLLLTGGGGAPPPQPSPQGA 377 L F G+ P L G P ++N G +LTGGGG PPP+P Sbjct: 529 LSGAGFPGMLGALPLPLSLGQPPPSPLLNHSLFG--------VLTGGGGQPPPEP----- 575 Query: 378 SETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVP-GPPTAA 436 +L P G PGP PLA P GP Sbjct: 576 -------LLPPPGG---------------------PGP--------PLAPGEPEGPSLLV 599 Query: 437 TFPLPPGPVPAVAAPQVVPLSPPPGYPTG--LSPTSPLLNLPQVVPTSQVVTLPQAVGPL 494 LPP P L PPP P L+ PLL L + + A GP Sbjct: 600 ASLLPPPP---------SDLLPPPSAPPSNLLASFLPLLALGPTAGDGE-GSAEGAGGPS 649 Query: 495 QLLAAGPG--SPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPI-- 550 +G G SP+ + P + +NS + L PS T P +L+ P G P Sbjct: 650 GEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSS 709 Query: 551 VTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSP---- 606 VT G L S Q+L P G +L L ++++ G LP P Sbjct: 710 VTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASL-LGDLSSLTSSPGALPSLLQPPGPL 768 Query: 607 --------ALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPA----PPPEG 654 LP A LS P A S P P++P L P PA P P Sbjct: 769 LSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPAR 828 Query: 655 LMLSPAAVP 663 LS A P Sbjct: 829 PPLSALAPP 837 Score = 49.3 bits (116), Expect = 1e-05 Identities = 128/501 (25%), Positives = 171/501 (34%), Gaps = 142/501 (28%) Query: 265 PCKSESDG--NPTTEDESSRSPEDLERGAAPV-------SAEAAAQGSIFLAGTGPPAPC 315 P S SDG N D P L G+ P S GS+ G PAP Sbjct: 421 PGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSV-PGAPAPP 479 Query: 316 PASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSP- 374 AS + +V L SP+ L G+ G A L PL GG P PSP Sbjct: 480 AASKAPVVPSPVLQ---SPSEGL--------GMGAGPACPLPPL----AGGEAFPFPSPE 524 Query: 375 QGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPT 434 QG + + G + L + + P P P L + G L PP Sbjct: 525 QGLALSGAGF--PGMLGALPLPLSLGQPP---------PSPLLNHSLFGVLTGGGGQPPP 573 Query: 435 AATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLS---------PTSPLLNLPQVVPTSQVV 485 P P GP P +A PG P G S P S LL P P++ + Sbjct: 574 EPLLPPPGGPGPPLA----------PGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNLLA 623 Query: 486 TLPQAVGPLQLLAAGPGS---PVKVAAAAGPANVHLINSGVG-VTALQLPSATAPGNFLL 541 + L LLA GP + A GP+ SG+G ++ L P +AP + Sbjct: 624 SF------LPLLALGPTAGDGEGSAEGAGGPSGEPF--SGLGDLSPLLFPPLSAPPTLIA 675 Query: 542 ANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLP 601 N S L++ L P G Sbjct: 676 LN--------------------------SALLAATLDPPSG------------------- 690 Query: 602 VAPSPALPEAHALGTLSAQQP-PPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA 660 P P + LSA QP PP ++ T++T+ P S G P+ PP+ +LSP Sbjct: 691 TPPQPCV--------LSAPQPGPPTSSVTTATTDP-GASSLGKAPSNSGRPPQ--LLSPL 739 Query: 661 AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEG-----LLLGATAGGEVD 715 G L L + L ++L+ P P G LL G A + Sbjct: 740 ------LGASLLGDLSSLTSSPGAL-----PSLLQPPGPLLSGQLGLQLLPGGGAPPPLS 788 Query: 716 EGLEAEAKVLTQLQSVPVEEP 736 E A +L LQ +P E+P Sbjct: 789 EASSPLACLLQSLQ-IPPEQP 808 Score = 45.1 bits (105), Expect = 2e-04 Identities = 96/411 (23%), Positives = 137/411 (33%), Gaps = 55/411 (13%) Query: 272 GNPTTEDESSRSPED--LERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLA 329 G+P SS P D L + ++ + A GP + P SS+ + L Sbjct: 243 GSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLG 302 Query: 330 A-SGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDP 388 G+P V G P + L A+ P P PS + Sbjct: 303 PLGGAPTVEGPGAPPFLASSLLSAAAK--------AQHPPLPPPSTLQGRRPRAQAPSAS 354 Query: 389 QTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPV-PA 447 + +R + + P T + GP VP P + P P P+ P+ Sbjct: 355 HSSSLRPSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQP---FSLPEPSQPILPS 411 Query: 448 VAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQ---------LLA 498 V + +P P + +LP PT + PQ P+Q L+ Sbjct: 412 VLSLLGLPTPGPSHSDGSFNLLGSDAHLPPP-PTLSSGSPPQPRHPIQPSLPGTTSGSLS 470 Query: 499 AGPGSPVKVAAAAGPANVHLINSGVGVTALQLPS---ATAPGNFLLANPVSGSPIVTGVA 555 + PG+P AA+ P V LQ PS G P++G + Sbjct: 471 SVPGAPAPPAASKAPV--------VPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPS 522 Query: 556 VQQGKIILTATFPTSMLVSQVLPPAPGLALP---LKPETAISVPEGGLPVAPSPALPEAH 612 +QG + A FP ML + LP + G P L + GG P P LP Sbjct: 523 PEQGLALSGAGFP-GMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPG 581 Query: 613 ALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVP 663 G PP A P P+ P LL PPP +L P + P Sbjct: 582 GPG-------PPLA--------PGEPEGPSLLVASLLPPPPSDLLPPPSAP 617 Score = 35.0 bits (79), Expect = 0.25 Identities = 63/234 (26%), Positives = 78/234 (33%), Gaps = 31/234 (13%) Query: 428 VVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLP-QVVPTSQVVT 486 V PGPP+A PP VP P S PP P +S P L P + P Sbjct: 138 VSPGPPSAR----PPCRVPPTTPLNGGPGSLPP-EPPSVSQAFPTLAGPGGLFPPRLADP 192 Query: 487 LPQ--AVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPS--ATAPGNFLLA 542 +P + P L SP A N N G + + +PS + P + Sbjct: 193 VPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASS 252 Query: 543 NPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLAL--PLKPET----AISVP 596 +P S P+ A P + S LP PG A P+ T + P Sbjct: 253 SPPSDPPLFH---------CSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGP 303 Query: 597 EGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAP 650 GG P P P A LS AAA LP G P AP Sbjct: 304 LGGAPTVEGPGAPPFLASSLLS------AAAKAQHPPLPPPSTLQGRRPRAQAP 351 >gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens] Length = 816 Score = 62.0 bits (149), Expect = 2e-09 Identities = 99/387 (25%), Positives = 128/387 (33%), Gaps = 51/387 (13%) Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGP----------- 415 A P QP P+G + V P+ S +P + A P P Sbjct: 258 AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPS 317 Query: 416 -----------ALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPT 464 +LG L +P PP + PP PA+A P PL PP P Sbjct: 318 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP---PLQAPPS-PP 373 Query: 465 GLSPTSPLLNLPQVVPTSQVVTLPQA------VGPLQLLAAGPGSPVKVAAAAGPANVHL 518 P SPL P + V L QA P+Q + P SP +A P+ Sbjct: 374 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433 Query: 519 INSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLP 578 + + P A+ P + P P + +Q K A + Q LP Sbjct: 434 SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493 Query: 579 PAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQ--QPPPAAATTSSTSLPF 636 P P A P LP++P A P A L+A Q PP+ + + P Sbjct: 494 SPPASF----PGQAPFSPSASLPMSPL-ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 548 Query: 637 SPDSPGLLPNFPAPPPE---GLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTV 693 P +PG P+ P L P P S LS L T P Sbjct: 549 RPPTPG--PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD---LAGHSSSATSTPEE- 602 Query: 694 LRLPDPDPEGLLLGATAGGEVDEGLEA 720 LR D PEG GA A D L A Sbjct: 603 LRGYDSGPEG---GAAASPPPDAELAA 626 Score = 55.1 bits (131), Expect = 2e-07 Identities = 82/322 (25%), Positives = 120/322 (37%), Gaps = 45/322 (13%) Query: 370 PQPSPQGASETKTSLVLDPQTGEVRLEEAQS--EAPETKGAQVAAPGPALGEEVLGPLAQ 427 P+ S ASE T+ +P R A + P ++ +A P GP A+ Sbjct: 196 PRKSVSSASEHSTT---EPSPAARRRPSAGGGLQRPASRSLSSSAT-PLSSPARSGPSAR 251 Query: 428 VVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTL 487 P P + P P G + A+ PQV P G PL + P P+ Sbjct: 252 GTPRAPAHPSQPKPKG-LQALRPPQVTPPRKDAAPALG-----PLSSSPLATPSPSAPPS 305 Query: 488 PQAVGPLQLLAAGPGSPVKVAAAA-GPANVHLINSGV--------------GVTALQLPS 532 P A LQ L + P +P A + G + +S + AL LP Sbjct: 306 PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 365 Query: 533 ATAPGNFLLANPVSGSPIVTGVAVQQGKI---ILTATF---PTSMLVSQVLPPA-----P 581 AP + + P+S P+ T + +L A F P+ + + PPA P Sbjct: 366 LQAPPSPPASPPLS--PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP 423 Query: 582 GLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSP 641 P + +++ P +P +P PA P T Q PPP AA + P P +P Sbjct: 424 SATPPSQAPPSLAAPPLQVPPSP-PASPPMSPSATPPPQAPPPLAAPPLQLAKP-PPQAP 481 Query: 642 GLLPNFPAPPPEGLMLSPAAVP 663 P PP + L PA+ P Sbjct: 482 ---PALATPPLQALPSPPASFP 500 Score = 54.3 bits (129), Expect = 4e-07 Identities = 167/710 (23%), Positives = 229/710 (32%), Gaps = 171/710 (24%) Query: 48 AAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRL 107 A AGA A AA A G +P PGSP P LR V A+ + A R Sbjct: 8 AKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALR-----VLGAAGAVGRKPLAERA 62 Query: 108 SRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLE-------------SRPFPA 154 GA P R R A RGE A + +RP P Sbjct: 63 GGIGGATIPESAPRAGPT--RTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 120 Query: 155 AHHAF---LQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKER 211 ++ R + EA + + GA R P P T R Sbjct: 121 GQKGLRISAEETVARGKATEAPKRSALSAGA----RRDTSGPTPGT------PSPAMARR 170 Query: 212 SRAA-------LKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNR--------RQRD 256 SRAA A R PT ++ +++ + S T+ S + R R Sbjct: 171 SRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 230 Query: 257 RTGAGGGAPCKSESDGNPTTEDE-------SSRSPEDLE-----------RGAAPVSAEA 298 R+ + P S + P+ S P+ L+ + AAP Sbjct: 231 RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 290 Query: 299 AAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGP 358 ++ + + PP+P A S+ S A S A G P + + + L P Sbjct: 291 SSSPLATPSPSAPPSPS-APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 349 Query: 359 LLLTGGGGAPPPQ-------------PSPQGASETKTSLVLDPQTGE---VRLEEAQSEA 402 L PPPQ PSP + PQ V L +A Sbjct: 350 L------ATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP 403 Query: 403 PETKGAQV-------------AAPGPALGEEVLGPLAQVVPGPPTA-----ATFPLPPGP 444 P + Q A P + P QV P PP + + P P P Sbjct: 404 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 463 Query: 445 VPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSP 504 P +AAP + PPP P L+ T PL LP P A P Q P S Sbjct: 464 PP-LAAPPLQLAKPPPQAPPALA-TPPLQALPS----------PPASFPGQ----APFS- 506 Query: 505 VKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILT 564 PSA+ P + L P P++ +Q + Sbjct: 507 --------------------------PSASLPMSPLATPPPQAPPVLAAPLLQ----VPP 536 Query: 565 ATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHA-LGTLSAQQPP 623 + + L + PP PG P+T++S P L +AP P P + + TLS P Sbjct: 537 SPPASPTLQAPRRPPTPG------PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSG--PD 588 Query: 624 PAAATTSSTSLP-----FSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAG 668 A ++S+TS P + G P P E PAA WS G Sbjct: 589 LAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAA---WSRG 635 >gi|47132519 Ras association and pleckstrin homology domains 1 isoform 1 [Homo sapiens] Length = 1250 Score = 62.0 bits (149), Expect = 2e-09 Identities = 86/326 (26%), Positives = 110/326 (33%), Gaps = 69/326 (21%) Query: 368 PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGE------EV 421 PPP PS S + + + RL+ A + GA P P + + ++ Sbjct: 646 PPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS----GALFKPPTPPVMQSQSVKPQI 701 Query: 422 LGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPL--------- 472 L P VVP PP P PP P P A Q+ P P P +P PL Sbjct: 702 LVPPNGVVPPPP-----PPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHIT 756 Query: 473 --------------LNLPQVVPTSQVVTLP-----QAVGPLQLLAA--GPGSPVKVAAAA 511 LP P +VT+P + V P+ AA P PV A Sbjct: 757 QVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQ 816 Query: 512 GPANVHLINSGVGVTALQLPSATAP--GNFLLANPVSGSPIVTGVAVQQGKIILTATFPT 569 I + +P T P +F P S V V Q P Sbjct: 817 PAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPP 876 Query: 570 SMLVSQVLPPAPGLALPLKPETAISVPE---GGLPVAPSPALPEAHALGTLSAQQPPPAA 626 +M SQ L P P P P + P+ +PV PSP P PPP Sbjct: 877 AM-ESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPV-PSPDFP------------PPP-- 920 Query: 627 ATTSSTSLPFSPDSPGLLPNFPAPPP 652 +SL F P P +P P PPP Sbjct: 921 ---PESSLVFPPPPPSPVPAPPPPPP 943 Score = 52.8 bits (125), Expect = 1e-06 Identities = 86/362 (23%), Positives = 118/362 (32%), Gaps = 62/362 (17%) Query: 352 EASSLGP-LLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKG--- 407 ++ S+ P +L+ G PPP P P + L P L + + P K Sbjct: 693 QSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQV 752 Query: 408 ---AQVAAPGPALGEEVLGPLAQVVPGPP---------TAATFPLPPGPVPAVAAPQVVP 455 QVA P P + PL P P T P+ P P V P Sbjct: 753 QHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP 812 Query: 456 LSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPAN 515 P +P P SP PT V P + Q A P P+ Sbjct: 813 AKKQPAFPASYIPPSP--------PTPPVPVPPPTLPKQQSFCAKP----------PPSP 854 Query: 516 VHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTAT--FPTSMLV 573 + + S V A Q P P + + P+ P+ VA Q + P+S+ V Sbjct: 855 LSPVPSVVKQIASQFPPPPTP-PAMESQPL--KPVPANVAPQSPPAVKAKPKWQPSSIPV 911 Query: 574 -SQVLPPAP---GLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSA-------QQP 622 S PP P L P P + + P P SP ++ + G ++ ++P Sbjct: 912 PSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKP 971 Query: 623 PPAAATTSSTSL--------PFSPDSPGLLPNFPAPPPEGL----MLSPAAVPVWSAGLE 670 PP SS P P L+ F P G L P A P L Sbjct: 972 PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLN 1031 Query: 671 LS 672 LS Sbjct: 1032 LS 1033 Score = 50.1 bits (118), Expect = 8e-06 Identities = 70/296 (23%), Positives = 104/296 (35%), Gaps = 23/296 (7%) Query: 366 GAPPPQPSPQGASETKTSLVLDPQTGE-VRLEEAQSEAPETKGAQVAAPGPALGEE--VL 422 G QP+ S++ S V +LEE+ E+ + P L + ++ Sbjct: 557 GVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIV 616 Query: 423 GPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTS 482 P P PP LPP P P P P PPP P+ +P++ P V S Sbjct: 617 TPYTASQPSPP------LPPPPPPPPPPPPPPP-PPPPPLPSQSAPSAGSA-APMFVKYS 668 Query: 483 QVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLL- 541 + L A L P PV + + P + + +GV P PG+ + Sbjct: 669 TITRLQNASQHSGALFKPPTPPVMQSQSVKP-QILVPPNGVVPPPPPPPPPPTPGSAMAQ 727 Query: 542 ANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLP 601 P +P + + + + + + PP P + PL P+ P L Sbjct: 728 LKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQ----APPKPLV 783 Query: 602 VAPSPALPEAHALGTLSAQQP---PPAAATTSSTSLPFS--PDSPGLLPNFPAPPP 652 P+P + A A P PP + P S P SP P P PPP Sbjct: 784 TIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPP-TPPVPVPPP 838 Score = 44.3 bits (103), Expect = 4e-04 Identities = 83/361 (22%), Positives = 127/361 (35%), Gaps = 49/361 (13%) Query: 369 PPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQV 428 PP P+P S L P V + + + K + P P+ P + + Sbjct: 870 PPPPTPPAME----SQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSL 925 Query: 429 VPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLS--------PTSPLLNLPQVVP 480 V PP + P PP P P A+P S PG T + P +P N + Sbjct: 926 VFPPPPPSPVPAPPPPPPPTASP-TPDKSGSPGKKTSKTSSPGGKKPPPTPQRN--SSIK 982 Query: 481 TSQVVTLPQAVGPL--QLLA-----AGPGSPVKVAA---AAGPANVHLINSGVGVTALQL 530 +S P+ P L++ A GSP K AA P L SGV + Sbjct: 983 SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNL----- 1037 Query: 531 PSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPE 590 PG + +P+++G +GK + FP+ S PP P LPL P Sbjct: 1038 -----PGVLQQGCVSAKAPVLSG----RGKDSVVE-FPSPPSDSDFPPPPPETELPLPPI 1087 Query: 591 TAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPA-------AATTSSTSLPFSPDSPGL 643 +V G + P+ +S ++ PP + + + P + Sbjct: 1088 EIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATV 1147 Query: 644 LPNFPAPPPEGLMLSPAAVPVWSAGLELSAGT-EGLLEAEKGLG-TQAPHTVLRLPDPDP 701 +P P P L + P + + L+ + T G L + A + LP P P Sbjct: 1148 VPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207 Query: 702 E 702 E Sbjct: 1208 E 1208 >gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens] Length = 1711 Score = 61.6 bits (148), Expect = 3e-09 Identities = 106/420 (25%), Positives = 163/420 (38%), Gaps = 53/420 (12%) Query: 311 PPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPP 370 PPAP AS V +F PA + + G V + +A + PL AP P Sbjct: 205 PPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQ-VATSVPAPSPPL-------APVP 256 Query: 371 QPSPQGASETKTSLVLDPQTGEVR---LEEAQSEAPETKGAQVAAPGPA-LGEEVLGPLA 426 +P A + +L+ D V L + AP + ++AP PA L V P Sbjct: 257 ALAP--APPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPL 314 Query: 427 QVV--PGPPTAATFPLPPGPVPAVA-----APQVVPLSPPPGYPTGLSPTSPLLNLPQVV 479 ++ P PP+A T L P P P +A P P P PT +P+S + P ++ Sbjct: 315 ALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTP-TPSSGPPSTPTLI 373 Query: 480 PTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNF 539 P +P A P + P +P+ A A I + ++ + P+A AP Sbjct: 374 PAFAPTPVP-APTPAPIFTPAP-TPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPA-- 429 Query: 540 LLANPVS---------GSPIVTGVAVQQGKIILTATFPTSMLVSQ--VLPPAPGLALPLK 588 + P+S P+V G+ + AT PT++ VS LP P Sbjct: 430 MQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRC 489 Query: 589 PETAISVPE-GGLPVAPSPALP--EAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLP 645 ++ PE P A S A P L +L + P + + S+T+ P PG L Sbjct: 490 LPGVLASPELRSYPYAFSVARPLTSDSKLVSLEVNRLPCTSPSGSTTTQPAPDGVPGPLA 549 Query: 646 NFP--------APPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLP 697 + P P+ L+ +P+ ++ +GTE E GT + L+ P Sbjct: 550 DTSLVTASAKVLPTPQPLLPAPSGSSAPPHPAKMPSGTEQQTE-----GTSVTFSPLKSP 604 >gi|112734870 hypothetical protein LOC57648 [Homo sapiens] Length = 1094 Score = 60.8 bits (146), Expect = 4e-09 Identities = 106/409 (25%), Positives = 143/409 (34%), Gaps = 106/409 (25%) Query: 353 ASSLGPLLLTGGGGAPPPQP----SPQGASETKTSLVLDPQTG----EVRLEEAQSEAPE 404 A+S P L GG PP P SP +++ P G +AQ PE Sbjct: 555 ANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPE 614 Query: 405 ------TKGAQVAAPGPALGEEVLGPLAQVVPGP----PTAATFPLPPGP-VPAVAAPQV 453 + GA V++ +L P GP P F +PP P VPA Sbjct: 615 RVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPA------ 668 Query: 454 VPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGP 513 P SPPP P +P +P L P VVP GP+ A P SP P Sbjct: 669 -PFSPPPSKPRSPNPAAPALAAPAVVP-----------GPVSTTDASPQSPPTPQTTLTP 716 Query: 514 ANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLV 573 + ++ Q P + P ++ P + P V V+ TA P L Sbjct: 717 -----LQESPVISKDQSPPPSPPPSYHPPPPPTKKP---EVVVEAPSASETAEEP---LQ 765 Query: 574 SQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQP----------- 622 PP P P PE E L +A P P A ++++ +P Sbjct: 766 DPNWPPPP----PPAPE------EQDLSMADFP--PPEEAFFSVASPEPAGPSGSPELVS 813 Query: 623 PPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAE 682 PAA+++S+T+L P P P PPP PA P Sbjct: 814 SPAASSSSATALQIQP------PGSPDPPP----APPAPAP------------------- 844 Query: 683 KGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSV 731 + AP V +LP +P G G GG E + A + LQ V Sbjct: 845 ---ASSAPGHVAKLPQKEPVGCSKG---GGPPREDVGAPLVTPSLLQMV 887 Score = 38.1 bits (87), Expect = 0.030 Identities = 75/332 (22%), Positives = 112/332 (33%), Gaps = 46/332 (13%) Query: 292 APVSAEAAAQGSIFLAGTGPPAPCPASSSILV-------NGSFLAASGSPAVLLNGGPVI 344 AP ++E A + PP P P + + F AS PA +G P + Sbjct: 753 APSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGP-SGSPEL 811 Query: 345 INGLALGEASSLGPLLLTGGGGAPPP-QPSPQGASETKTSLVLDPQTGEVRLEEAQSEAP 403 ++ A +S+ + G PPP P+P AS + PQ V + Sbjct: 812 VSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPR 871 Query: 404 ETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP-LPPGPVPAVAAPQVVPLSPPPGY 462 E GA + P+L + V G PT A P P P+ + + SP P Sbjct: 872 EDVGAPLVT--PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRA---SPVPAP 926 Query: 463 PTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSG 522 +GL L + S+ ++ Q GP + P SP A+ Sbjct: 927 SSGLHAAVRLKACS--LAASEGLSSAQPNGPPEAEPRPPQSPASTAS---------FIFS 975 Query: 523 VGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPG 582 G LQL +P T +Q+ + + +S+ PP Sbjct: 976 KGSRKLQLERPVSP--------------ETQADLQRNLVAELRS------ISEQRPPQAP 1015 Query: 583 LALPLKPETAISVPEGGLPVAPSPALPEAHAL 614 P P P G+P SP+ P A L Sbjct: 1016 KKSPKAPPPVARKPSVGVPPPASPSYPRAEPL 1047 Score = 36.6 bits (83), Expect = 0.086 Identities = 29/89 (32%), Positives = 37/89 (41%), Gaps = 9/89 (10%) Query: 577 LPPAPGLA----LPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSST 632 LPP P LP P T S G P P+PA L +++PP + T S Sbjct: 521 LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580 Query: 633 SLPFSPDSPGLLPNFPAPPPEGLMLSPAA 661 S +S S P PP+GL PA+ Sbjct: 581 SSGYSSQS-----GTPTLPPKGLAGPPAS 604 Score = 33.1 bits (74), Expect = 0.95 Identities = 37/146 (25%), Positives = 54/146 (36%), Gaps = 17/146 (11%) Query: 578 PPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFS 637 PP P + ++VP+G L + P P + L +PP + + + P Sbjct: 497 PPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQL-----PRPPTTGGSEGAGAAPCP 551 Query: 638 PDS-----PGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHT 692 P+ PGL P PP SP S+G +GT L KGL P + Sbjct: 552 PNPANSWVPGLSPGGSRRPPR----SPERTLSPSSGYSSQSGTPTL--PPKGL-AGPPAS 604 Query: 693 VLRLPDPDPEGLLLGATAGGEVDEGL 718 + P PE + + G V L Sbjct: 605 PGKAQPPKPERVTSLRSPGASVSSSL 630 >gi|112382226 atrophin-1 like protein isoform b [Homo sapiens] Length = 1012 Score = 60.5 bits (145), Expect = 6e-09 Identities = 83/318 (26%), Positives = 112/318 (35%), Gaps = 50/318 (15%) Query: 368 PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGA---QVAAPGPALGEEVL-- 422 P PQ + + + +L Q ++ + AP + Q+ PGP + Sbjct: 162 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 221 Query: 423 --GPLAQVVPGPPTAATFPLPPGPVPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQV 478 P A P P A T P+P + A PQ P PP +P+ P PL Sbjct: 222 QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS--- 278 Query: 479 VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGN 538 P A Q G G P + AGP L+ LP + G Sbjct: 279 ------AGQPSAPSHAQPPLHGQGPPGPHSLQAGP----LLQHPGPPQPFGLPPQASQGQ 328 Query: 539 FLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALP-LKPETAISVPE 597 L + + T + + + L + P Q LPPAP LA+P +KP +P+ Sbjct: 329 APLGTSPAAAYPHTSLQLPASQSALQSQQPPR---EQPLPPAP-LAMPHIKPPPTTPIPQ 384 Query: 598 GGLPVA---------PSPA-----LPEAHALGTLSA--------QQPPPAAATTSSTSLP 635 P A PSP LP AL LS+ PPP S LP Sbjct: 385 LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLP 444 Query: 636 FSP-DSPGLLPNFPAPPP 652 SP PGL + PPP Sbjct: 445 SSPAQPPGLTQSQNLPPP 462 Score = 35.8 bits (81), Expect = 0.15 Identities = 96/384 (25%), Positives = 125/384 (32%), Gaps = 73/384 (19%) Query: 272 GNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP-PAPCPASSSILVNGSFLAA 330 G+PT +S++P + APV Q P P P P S + Sbjct: 223 GSPT----ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS 278 Query: 331 SGSPAVLLNGGPVIINGLALGEAS-SLGPLLLTGGGGAP---PPQPSPQGASETKTSLVL 386 +G P+ + P + G S GPLL G P PPQ S QG + TS Sbjct: 279 AGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQAS-QGQAPLGTSPAA 337 Query: 387 DPQTGEVRLEEAQS--EAPETKGAQVAAPGPALGEEVLGPLAQVVPG------------- 431 ++L +QS ++ + Q P P + P +P Sbjct: 338 AYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHL 397 Query: 432 ------------PPTAATFPL-------PPG--PVPAVAAPQVVPLSPPPGYPTGLSPTS 470 PP A PL PP P P PQ PL P P GL+ + Sbjct: 398 SGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQ 457 Query: 471 PLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQL 530 NLP P S T V P A P P GP +T Sbjct: 458 ---NLPP-PPASHPPTGLHQVAPQPPFAQHPFVP------GGPP---------PITPPTC 498 Query: 531 PSATAPGNFLLANP-VSGSPIVTGVAVQQGKII--LTATFPTSMLVSQVLPPAPGLALPL 587 PS + P A P S P +G A G I + PT + + L A P Sbjct: 499 PSTSTPP----AGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP 554 Query: 588 KPETAISVPEGGLPVAPSPALPEA 611 P + S PE + PS A A Sbjct: 555 PPPRSPS-PEPTVVDTPSHASQSA 577 Score = 30.0 bits (66), Expect = 8.1 Identities = 38/150 (25%), Positives = 51/150 (34%), Gaps = 12/150 (8%) Query: 568 PTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAA 627 P ++ + PAP A P P+ P P P A + + QP A Sbjct: 184 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTA----SQAPNQPQAPTA 239 Query: 628 TTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGT 687 T + +P P P PPP P SAG + SA + G G Sbjct: 240 PVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAG-QPSAPSHAQPPLH-GQGP 297 Query: 688 QAPHTVLRLP------DPDPEGLLLGATAG 711 PH++ P P P GL A+ G Sbjct: 298 PGPHSLQAGPLLQHPGPPQPFGLPPQASQG 327 >gi|112382224 atrophin-1 like protein isoform a [Homo sapiens] Length = 1566 Score = 60.5 bits (145), Expect = 6e-09 Identities = 83/318 (26%), Positives = 112/318 (35%), Gaps = 50/318 (15%) Query: 368 PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGA---QVAAPGPALGEEVL-- 422 P PQ + + + +L Q ++ + AP + Q+ PGP + Sbjct: 716 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 775 Query: 423 --GPLAQVVPGPPTAATFPLPPGPVPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQV 478 P A P P A T P+P + A PQ P PP +P+ P PL Sbjct: 776 QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS--- 832 Query: 479 VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGN 538 P A Q G G P + AGP L+ LP + G Sbjct: 833 ------AGQPSAPSHAQPPLHGQGPPGPHSLQAGP----LLQHPGPPQPFGLPPQASQGQ 882 Query: 539 FLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALP-LKPETAISVPE 597 L + + T + + + L + P Q LPPAP LA+P +KP +P+ Sbjct: 883 APLGTSPAAAYPHTSLQLPASQSALQSQQPPR---EQPLPPAP-LAMPHIKPPPTTPIPQ 938 Query: 598 GGLPVA---------PSPA-----LPEAHALGTLSA--------QQPPPAAATTSSTSLP 635 P A PSP LP AL LS+ PPP S LP Sbjct: 939 LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLP 998 Query: 636 FSP-DSPGLLPNFPAPPP 652 SP PGL + PPP Sbjct: 999 SSPAQPPGLTQSQNLPPP 1016 Score = 35.8 bits (81), Expect = 0.15 Identities = 96/384 (25%), Positives = 125/384 (32%), Gaps = 73/384 (19%) Query: 272 GNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP-PAPCPASSSILVNGSFLAA 330 G+PT +S++P + APV Q P P P P S + Sbjct: 777 GSPT----ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS 832 Query: 331 SGSPAVLLNGGPVIINGLALGEAS-SLGPLLLTGGGGAP---PPQPSPQGASETKTSLVL 386 +G P+ + P + G S GPLL G P PPQ S QG + TS Sbjct: 833 AGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQAS-QGQAPLGTSPAA 891 Query: 387 DPQTGEVRLEEAQS--EAPETKGAQVAAPGPALGEEVLGPLAQVVPG------------- 431 ++L +QS ++ + Q P P + P +P Sbjct: 892 AYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHL 951 Query: 432 ------------PPTAATFPL-------PPG--PVPAVAAPQVVPLSPPPGYPTGLSPTS 470 PP A PL PP P P PQ PL P P GL+ + Sbjct: 952 SGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQ 1011 Query: 471 PLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQL 530 NLP P S T V P A P P GP +T Sbjct: 1012 ---NLPP-PPASHPPTGLHQVAPQPPFAQHPFVP------GGPP---------PITPPTC 1052 Query: 531 PSATAPGNFLLANP-VSGSPIVTGVAVQQGKII--LTATFPTSMLVSQVLPPAPGLALPL 587 PS + P A P S P +G A G I + PT + + L A P Sbjct: 1053 PSTSTPP----AGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP 1108 Query: 588 KPETAISVPEGGLPVAPSPALPEA 611 P + S PE + PS A A Sbjct: 1109 PPPRSPS-PEPTVVDTPSHASQSA 1131 Score = 30.0 bits (66), Expect = 8.1 Identities = 38/150 (25%), Positives = 51/150 (34%), Gaps = 12/150 (8%) Query: 568 PTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAA 627 P ++ + PAP A P P+ P P P A + + QP A Sbjct: 738 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTA----SQAPNQPQAPTA 793 Query: 628 TTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGT 687 T + +P P P PPP P SAG + SA + G G Sbjct: 794 PVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAG-QPSAPSHAQPPLH-GQGP 851 Query: 688 QAPHTVLRLP------DPDPEGLLLGATAG 711 PH++ P P P GL A+ G Sbjct: 852 PGPHSLQAGPLLQHPGPPQPFGLPPQASQG 881 >gi|112382216 atrophin-1 like protein isoform a [Homo sapiens] Length = 1566 Score = 60.5 bits (145), Expect = 6e-09 Identities = 83/318 (26%), Positives = 112/318 (35%), Gaps = 50/318 (15%) Query: 368 PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGA---QVAAPGPALGEEVL-- 422 P PQ + + + +L Q ++ + AP + Q+ PGP + Sbjct: 716 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 775 Query: 423 --GPLAQVVPGPPTAATFPLPPGPVPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQV 478 P A P P A T P+P + A PQ P PP +P+ P PL Sbjct: 776 QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS--- 832 Query: 479 VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGN 538 P A Q G G P + AGP L+ LP + G Sbjct: 833 ------AGQPSAPSHAQPPLHGQGPPGPHSLQAGP----LLQHPGPPQPFGLPPQASQGQ 882 Query: 539 FLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALP-LKPETAISVPE 597 L + + T + + + L + P Q LPPAP LA+P +KP +P+ Sbjct: 883 APLGTSPAAAYPHTSLQLPASQSALQSQQPPR---EQPLPPAP-LAMPHIKPPPTTPIPQ 938 Query: 598 GGLPVA---------PSPA-----LPEAHALGTLSA--------QQPPPAAATTSSTSLP 635 P A PSP LP AL LS+ PPP S LP Sbjct: 939 LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLP 998 Query: 636 FSP-DSPGLLPNFPAPPP 652 SP PGL + PPP Sbjct: 999 SSPAQPPGLTQSQNLPPP 1016 Score = 35.8 bits (81), Expect = 0.15 Identities = 96/384 (25%), Positives = 125/384 (32%), Gaps = 73/384 (19%) Query: 272 GNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP-PAPCPASSSILVNGSFLAA 330 G+PT +S++P + APV Q P P P P S + Sbjct: 777 GSPT----ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS 832 Query: 331 SGSPAVLLNGGPVIINGLALGEAS-SLGPLLLTGGGGAP---PPQPSPQGASETKTSLVL 386 +G P+ + P + G S GPLL G P PPQ S QG + TS Sbjct: 833 AGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQAS-QGQAPLGTSPAA 891 Query: 387 DPQTGEVRLEEAQS--EAPETKGAQVAAPGPALGEEVLGPLAQVVPG------------- 431 ++L +QS ++ + Q P P + P +P Sbjct: 892 AYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHL 951 Query: 432 ------------PPTAATFPL-------PPG--PVPAVAAPQVVPLSPPPGYPTGLSPTS 470 PP A PL PP P P PQ PL P P GL+ + Sbjct: 952 SGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQ 1011 Query: 471 PLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQL 530 NLP P S T V P A P P GP +T Sbjct: 1012 ---NLPP-PPASHPPTGLHQVAPQPPFAQHPFVP------GGPP---------PITPPTC 1052 Query: 531 PSATAPGNFLLANP-VSGSPIVTGVAVQQGKII--LTATFPTSMLVSQVLPPAPGLALPL 587 PS + P A P S P +G A G I + PT + + L A P Sbjct: 1053 PSTSTPP----AGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP 1108 Query: 588 KPETAISVPEGGLPVAPSPALPEA 611 P + S PE + PS A A Sbjct: 1109 PPPRSPS-PEPTVVDTPSHASQSA 1131 Score = 30.0 bits (66), Expect = 8.1 Identities = 38/150 (25%), Positives = 51/150 (34%), Gaps = 12/150 (8%) Query: 568 PTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAA 627 P ++ + PAP A P P+ P P P A + + QP A Sbjct: 738 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTA----SQAPNQPQAPTA 793 Query: 628 TTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGT 687 T + +P P P PPP P SAG + SA + G G Sbjct: 794 PVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAG-QPSAPSHAQPPLH-GQGP 851 Query: 688 QAPHTVLRLP------DPDPEGLLLGATAG 711 PH++ P P P GL A+ G Sbjct: 852 PGPHSLQAGPLLQHPGPPQPFGLPPQASQG 881 >gi|149773456 hypothetical protein LOC643314 [Homo sapiens] Length = 1427 Score = 60.1 bits (144), Expect = 7e-09 Identities = 116/496 (23%), Positives = 161/496 (32%), Gaps = 73/496 (14%) Query: 277 EDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAV 336 ED ++ + ER P + +G+ +A P A A Sbjct: 894 EDVTAAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEE--------------TAPAVAAA 939 Query: 337 LLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLE 396 + G + G + A+ + +T G P +P T +P T VR+ Sbjct: 940 ITQEGMSAVAGFSPEWAALAITVPITEEDGTPEGPVTPA----TTVHAPEEPDTAAVRV- 994 Query: 397 EAQSEAPETKGAQVAAPGPALGEEVLGPLAQV-VPGPPTAATFPLPP-----GPVPAVAA 450 + E P + A V P EE P A V P PT+ +PP P AV Sbjct: 995 -STPEEPASPAAAVPTP-----EEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPT 1048 Query: 451 PQVVPLSPPPGYPTGLSPTSPLLNLP---------QVVPTSQVVTLPQAVGPLQLLAAGP 501 P+ P SP PT PTSP +P VPT + T P A P P Sbjct: 1049 PEE-PTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSP 1107 Query: 502 GSPVKV------AAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVA 555 + V AAA P + V + P+ AP + P + V Sbjct: 1108 AAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPA---VPTPEESASAAVAVP 1164 Query: 556 VQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPE--AHA 613 + A PT + L P P A SVP P A L E + A Sbjct: 1165 TPEESASPAAAVPTPAESASFAAVVATLEEPTSP--AASVP---TPAAMVATLEEFTSPA 1219 Query: 614 LGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAP--------PPEGLMLSPAAVPVW 665 ++++P AA S+ P SP +P P PE L A+VP Sbjct: 1220 ASVPTSEEPASLAAAVSNPEEPTSP--AAAVPTLEEPTSSAAAVLTPEELSSPAASVPTP 1277 Query: 666 SAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPD---PDPEGLLLGATAGGEVDEGLEAEA 722 +A L E V +P P PE + A A ++E Sbjct: 1278 EEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPPMEEVSPIGV 1337 Query: 723 KVL---TQLQSVPVEE 735 L SVP+ E Sbjct: 1338 PFLGVSAHTDSVPISE 1353 >gi|239742468 PREDICTED: double homeobox, 4-like [Homo sapiens] Length = 485 Score = 60.1 bits (144), Expect = 7e-09 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%) Query: 43 EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98 +G A AG AA A V GSPP + P+ ++F P A ++ Sbjct: 13 QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71 Query: 99 LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153 L A GR R P++ LRA F+R Y A RL ++ P P Sbjct: 72 LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122 Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208 F + + R H E RG G R+K +T G +T Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167 Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268 A L + +R+P + LA TGL +++ WF+NRR R G GG AP ++ Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221 Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327 G + P AP A G+ GTG PAP P + L G+F Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268 Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387 ++ + A P + A P G P P P GA + Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321 Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444 P G+ R + VA PGPA GP Q V PPT+ P GP Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377 Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488 A AA PQ PP P S ++ + + SQ + P Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423 >gi|194272172 double homeobox, 4 [Homo sapiens] Length = 485 Score = 60.1 bits (144), Expect = 7e-09 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%) Query: 43 EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98 +G A AG AA A V GSPP + P+ ++F P A ++ Sbjct: 13 QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71 Query: 99 LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153 L A GR R P++ LRA F+R Y A RL ++ P P Sbjct: 72 LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122 Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208 F + + R H E RG G R+K +T G +T Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167 Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268 A L + +R+P + LA TGL +++ WF+NRR R G GG AP ++ Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221 Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327 G + P AP A G+ GTG PAP P + L G+F Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268 Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387 ++ + A P + A P G P P P GA + Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321 Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444 P G+ R + VA PGPA GP Q V PPT+ P GP Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377 Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488 A AA PQ PP P S ++ + + SQ + P Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423 >gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo sapiens] Length = 1560 Score = 60.1 bits (144), Expect = 7e-09 Identities = 116/433 (26%), Positives = 155/433 (35%), Gaps = 91/433 (21%) Query: 307 AGTGPPAPCP-ASSSILVNGSFLAA----SGSPAVLLNGGPVIINGLALGEAS---SLGP 358 + GP P AS+ + G+ L S + A LNG V A + S P Sbjct: 265 SAAGPSEPVTLASAGVSPQGAGLVIQKNLSAAVATTLNGNSVFGGAGAASAPTGTPSGQP 324 Query: 359 LLLTGGGGAPPPQPSPQ-------GASETKTSLVLDPQT------------------GEV 393 L + G G+ P P+P + K + VL P+ GE Sbjct: 325 LAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQGEP 384 Query: 394 RLEEAQSEAPETKGAQVAA-----------PGPALGEEVLGPLAQVVPGPPTAATFPLPP 442 Q +AP+ A P PAL A V PP T PP Sbjct: 385 GALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQ-------ANVFKQPPATTTGAAPP 437 Query: 443 GPVPAVAAPQVVPLSPP------------PGYPTGLSPTSPLLNLPQVVPTSQVVTLPQA 490 P A++ P V L PG L P +P + LPQ Q+ LP Sbjct: 438 QPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLPQ-----QLSALPAN 492 Query: 491 VGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL-LANPVSGSP 549 VG L AA P + ++ A N +L L L AP + A+ +S +P Sbjct: 493 VGGQILAAAAPHTGGQLIANPILTNQNLAGP------LSLGPVLAPHSGAHSAHILSAAP 546 Query: 550 IVTGV-AVQQGKIILTA-TFPTSMLVSQVLPPAP-------GLALPLKPETAISVPEGGL 600 I G A+ Q + L A + PT SQ P P G+ LP ++ P+G + Sbjct: 547 IQVGQPALFQMPVSLAAGSLPTQ---SQPAPAGPAATTVLQGVTLPPSAVAMLNTPDGLV 603 Query: 601 -PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSP 659 P P+ A EA + T+ QP P A ST LP P AP P+ Sbjct: 604 QPATPAAATGEAAPVLTV---QPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQ 660 Query: 660 AAVPVWSAGLELS 672 A P S GL S Sbjct: 661 ATTPQPSPGLASS 673 Score = 56.2 bits (134), Expect = 1e-07 Identities = 105/411 (25%), Positives = 149/411 (36%), Gaps = 99/411 (24%) Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426 APPP P A+ L PQ + S+A Q+ A P G Sbjct: 726 APPPAQDPAPATPVAKGAGLGPQAPD-------SQASPAPAPQIPAAAPLKG-------- 770 Query: 427 QVVPGPPTAATFP--LPPGPVPAVAAPQVV-PLSPPPGYPTGLS--PTSPLLNL---PQV 478 PGP ++ + P P G P + +P P S PP P +S P+ P L+ PQ Sbjct: 771 ---PGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQA 827 Query: 479 VPTSQVVTL---------------PQAVGP----LQLLAAGPGSPVKVAAAAGPANVHLI 519 PT + + P A GP L+ + P P+ A P++ Sbjct: 828 PPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSA 887 Query: 520 NSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPP 579 + T+ +LP+ T P +F L P S P + PT LV P Sbjct: 888 VASSSETSSRLPAPT-PSDFQLQFPPSQGPHKSPTPP-----------PTLHLV-----P 930 Query: 580 APGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQP-----------PPAAAT 628 P P P T V P PALP+ AL Q P PAA Sbjct: 931 EPAAPPPPPPRTFQMV------TTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQ 984 Query: 629 TSSTSLPFSPDSPGLLPNFPAP--PPEGLMLSPAAVPVWSAGLELSAGTEGLLEAE-KGL 685 TS++ P + + +L + AP P +PA P+ + GL LL AE K Sbjct: 985 TSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGL------PPLLPAENKAF 1038 Query: 686 GTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSVPVEEP 736 + P + A++G GL+ E+K L+ L+ P +P Sbjct: 1039 ASNLPTL----------NVAKAASSGPGKPSGLQYESK-LSGLKKPPTLQP 1078 Score = 53.1 bits (126), Expect = 9e-07 Identities = 109/451 (24%), Positives = 155/451 (34%), Gaps = 76/451 (16%) Query: 269 ESDGNPTTEDESSRSPE-DLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSF 327 E+ GN + + +P DL+ + A G +G G PC L + Sbjct: 55 EASGNHLNPEPNQPAPSVDLDFLEDDILGSPATGGGGGGSG-GADQPCDILQQSLQEANI 113 Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387 + L+ GP + L + + GP TG GGA PQ T L+ Sbjct: 114 TEQTLEAEAELDLGPFQLPTLQPADGGA-GP---TGAGGAAAVAAGPQALFPGSTDLL-- 167 Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPG---- 443 G Q P L + L P VV + F P G Sbjct: 168 -------------------GLQ--GPPTVLTHQALVPPQDVVNKALSVQPFLQPVGLGNV 206 Query: 444 ---PVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVV-----PTSQVVTLPQAVGPLQ 495 P+P + Q +P P G +P+ + Q V PTSQ++ V Sbjct: 207 TLQPIPGL---QGLPNGSPGGATAATLGLAPIQVVGQPVMALNTPTSQLLAKQVPVSGYL 263 Query: 496 LLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVA 555 AAGP PV +A+A + G G+ + SA +A ++G+ + G Sbjct: 264 ASAAGPSEPVTLASAG------VSPQGAGLVIQKNLSAA------VATTLNGNSVFGGAG 311 Query: 556 VQQGKIILTATFPTSMLVSQVLPPAPGL-ALPLKPETAISVPEGGLPVAPSPALPEAHAL 614 A+ PT Q L APGL + PL P + + P+ P PA L Sbjct: 312 --------AASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKL 363 Query: 615 GTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAG 674 L+ + PA AT + PG LP P P L+ A + LS Sbjct: 364 YQLTPKPFAPAGATLTIQG------EPGALPQQPKAPQN---LTFMAAGKAGQNVVLSGF 414 Query: 675 TEGLLEAEKGLGTQAPHTVLRLPDPDPEGLL 705 L+A + Q P T P P G L Sbjct: 415 PAPALQA--NVFKQPPATTTGAAPPQPPGAL 443 Score = 50.8 bits (120), Expect = 4e-06 Identities = 104/415 (25%), Positives = 146/415 (35%), Gaps = 80/415 (19%) Query: 293 PVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGE 352 PVS A + L PAP +++ ++ G L S +LN ++ Sbjct: 558 PVSLAAGS-----LPTQSQPAPAGPAATTVLQGVTLPPSA--VAMLNTPDGLVQPATPAA 610 Query: 353 ASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAA 412 A+ +LT QP+PQ T L L Q + + + P+ Q AA Sbjct: 611 ATGEAAPVLT-------VQPAPQAPPAVSTPLPLGLQQPQAQ------QPPQAPTPQAAA 657 Query: 413 PGPALGEEVLGPLA----QVVPGPPTAAT--------------------FPLPP-GPVPA 447 P A + LA ++V G P +AT PL GP + Sbjct: 658 PPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLS 717 Query: 448 VAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKV 507 V A +V PP P +P + L P SQ P P GPG Sbjct: 718 VPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPG----- 772 Query: 508 AAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGS-----------------PI 550 ++ P+ H G L P T P + + P S S P Sbjct: 773 -PSSSPSLPHQAPLG-DSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPT 830 Query: 551 VTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLAL-PLKPETAISVPEGGLPVAPS-PAL 608 + G+ V Q ++ + S P APG PL+P++ PEG LP AP P Sbjct: 831 LPGIFVIQNQLGVPPP------ASNPAPTAPGPPQPPLRPQS--QPPEGPLPPAPHLPPS 882 Query: 609 PEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVP 663 + A+ + S A T S L F P S G + PP L+ PAA P Sbjct: 883 STSSAVASSSETSSRLPAPTPSDFQLQF-PPSQGPHKSPTPPPTLHLVPEPAAPP 936 Score = 32.3 bits (72), Expect = 1.6 Identities = 29/89 (32%), Positives = 38/89 (42%), Gaps = 20/89 (22%) Query: 5 PAEPSAGPAAGG---------EAVAAAAATEEEEEEARQL------LQTLQAAEGEAAAA 49 PA G +GG +++ A TE+ E +L L TLQ A+G A Sbjct: 85 PATGGGGGGSGGADQPCDILQQSLQEANITEQTLEAEAELDLGPFQLPTLQPADGGAGPT 144 Query: 50 AGAGAGAAAAGAEG--PGSP---GVPGSP 73 GA A AAG + PGS G+ G P Sbjct: 145 GAGGAAAVAAGPQALFPGSTDLLGLQGPP 173 Score = 30.4 bits (67), Expect = 6.2 Identities = 57/219 (26%), Positives = 75/219 (34%), Gaps = 43/219 (19%) Query: 308 GTGPPAPC--PASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGP--LLLTG 363 G PPAP P+S+S V S +S PA + + S P L L Sbjct: 871 GPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVP 930 Query: 364 GGGAPPPQPSPQGASETKTSLVLDPQTGEV--RLEEAQS------------EAPETKGAQ 409 APPP P P+ T PQ + R + S AP+T + Sbjct: 931 EPAAPPPPP-PRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSL 989 Query: 410 VAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVP-------------- 455 PA V G Q G PTA + P P+ A P ++P Sbjct: 990 GPLTSPAASVLVSG---QAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFASNLPTLN 1046 Query: 456 ----LSPPPGYPTGLSPTSPLLNL---PQVVPTSQVVTL 487 S PG P+GL S L L P + P+ + L Sbjct: 1047 VAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFL 1085 >gi|194272217 double homeobox, 4-like [Homo sapiens] Length = 485 Score = 60.1 bits (144), Expect = 7e-09 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%) Query: 43 EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98 +G A AG AA A V GSPP + P+ ++F P A ++ Sbjct: 13 QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71 Query: 99 LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153 L A GR R P++ LRA F+R Y A RL ++ P P Sbjct: 72 LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122 Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208 F + + R H E RG G R+K +T G +T Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167 Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268 A L + +R+P + LA TGL +++ WF+NRR R G GG AP ++ Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221 Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327 G + P AP A G+ GTG PAP P + L G+F Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268 Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387 ++ + A P + A P G P P P GA + Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321 Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444 P G+ R + VA PGPA GP Q V PPT+ P GP Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377 Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488 A AA PQ PP P S ++ + + SQ + P Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423 >gi|194272216 double homeobox, 4-like [Homo sapiens] Length = 485 Score = 60.1 bits (144), Expect = 7e-09 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%) Query: 43 EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98 +G A AG AA A V GSPP + P+ ++F P A ++ Sbjct: 13 QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71 Query: 99 LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153 L A GR R P++ LRA F+R Y A RL ++ P P Sbjct: 72 LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122 Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208 F + + R H E RG G R+K +T G +T Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167 Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268 A L + +R+P + LA TGL +++ WF+NRR R G GG AP ++ Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221 Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327 G + P AP A G+ GTG PAP P + L G+F Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268 Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387 ++ + A P + A P G P P P GA + Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321 Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444 P G+ R + VA PGPA GP Q V PPT+ P GP Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377 Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488 A AA PQ PP P S ++ + + SQ + P Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423 >gi|194272215 double homeobox, 4-like [Homo sapiens] Length = 485 Score = 60.1 bits (144), Expect = 7e-09 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%) Query: 43 EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98 +G A AG AA A V GSPP + P+ ++F P A ++ Sbjct: 13 QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71 Query: 99 LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153 L A GR R P++ LRA F+R Y A RL ++ P P Sbjct: 72 LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122 Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208 F + + R H E RG G R+K +T G +T Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167 Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268 A L + +R+P + LA TGL +++ WF+NRR R G GG AP ++ Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221 Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327 G + P AP A G+ GTG PAP P + L G+F Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268 Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387 ++ + A P + A P G P P P GA + Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321 Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444 P G+ R + VA PGPA GP Q V PPT+ P GP Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377 Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488 A AA PQ PP P S ++ + + SQ + P Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423 >gi|194272192 double homeobox, 4-like [Homo sapiens] Length = 485 Score = 60.1 bits (144), Expect = 7e-09 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%) Query: 43 EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98 +G A AG AA A V GSPP + P+ ++F P A ++ Sbjct: 13 QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71 Query: 99 LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153 L A GR R P++ LRA F+R Y A RL ++ P P Sbjct: 72 LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122 Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208 F + + R H E RG G R+K +T G +T Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167 Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268 A L + +R+P + LA TGL +++ WF+NRR R G GG AP ++ Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221 Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327 G + P AP A G+ GTG PAP P + L G+F Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268 Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387 ++ + A P + A P G P P P GA + Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321 Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444 P G+ R + VA PGPA GP Q V PPT+ P GP Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377 Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488 A AA PQ PP P S ++ + + SQ + P Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423 >gi|91982772 mucin 17 [Homo sapiens] Length = 4493 Score = 59.7 bits (143), Expect = 1e-08 Identities = 84/384 (21%), Positives = 148/384 (38%), Gaps = 43/384 (11%) Query: 275 TTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSP 334 TT E++ SP E + P S + GT P P S +++ N S +P Sbjct: 2252 TTSTEATSSPTTAEGTSIPTSTLSE--------GTTPLTSIPVSHTLVANSEVSTLSTTP 2303 Query: 335 AVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASE-----TKTSLVLDPQ 389 + P + EASS P T G + P S +G + T++V + Sbjct: 2304 VD--SNTPFTTST----EASSPPP---TAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFE 2354 Query: 390 TGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVA 449 T + A + P T +Q A P ++ P + G + P+ +P V+ Sbjct: 2355 TSTLSTTPADTSTPVTTYSQ-AGSSPTTADDTSMPTSTYSEGSTPLTSVPV--STMPVVS 2411 Query: 450 APQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAA 509 + + P T ++ ++ + P + + T P + G L + + V++ Sbjct: 2412 SEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSS 2471 Query: 510 AAGPANVHLINSGVGVTA-------------LQLPSATAP-GNFLLAN-PVSGSPIVTGV 554 AG + +++ +T + +P +TA G+ LL + PVS +P+ + Sbjct: 2472 EAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPE 2531 Query: 555 AVQQGKIILTATFP--TSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSP-ALPEA 611 A + + P TS +S A G ++P + S P +PV+ P A EA Sbjct: 2532 ASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEA 2591 Query: 612 HALGTLSAQQPPPAAATTSSTSLP 635 L T P +T ++S P Sbjct: 2592 STLSTTPVDTSIPVTTSTETSSSP 2615 Score = 55.8 bits (133), Expect = 1e-07 Identities = 88/400 (22%), Positives = 147/400 (36%), Gaps = 36/400 (9%) Query: 268 SESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSF 327 +E+ +PTT + +S + P+++ + + G + P +S V S Sbjct: 2786 TEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTST 2845 Query: 328 LAASGSPAVLLNGGPVIINGLALG-EASSLGPLLLTGGGGAPPPQPSPQGASETKT--SL 384 A+S P G+ + +S G LLT + P +P +SE T + Sbjct: 2846 KASSS---------PTTAEGIVVPISTASEGSTLLT----SIPVSTTPVASSEASTLSTT 2892 Query: 385 VLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQV-VPGPPTAATFPLPPG 443 +D E S +G + P+ EV PL + V P A + Sbjct: 2893 PVDTSIPVTTSTEGSSSPTTAEGTSMPISTPS---EVSTPLTSILVSTVPVAGSEASTLS 2949 Query: 444 PVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLP----QVVPTSQVVTLPQAVGPLQLLAA 499 P V + PT TS ++ P + + V T+P A L+ Sbjct: 2950 TTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSR 3009 Query: 500 GPG---SPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAV 556 P +PV + A + +G+ ++ S L + PVS +P+ A Sbjct: 3010 TPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTP-----LTSIPVSTTPVAIPEAS 3064 Query: 557 QQGKIILTATFP--TSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHAL 614 + + P TS VS PA G ++P+ + S P G+PV+ +P + A+ Sbjct: 3065 TLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPV--TSSAI 3122 Query: 615 GTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEG 654 TLS + T+ST SP + + P EG Sbjct: 3123 STLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEG 3162 Score = 42.7 bits (99), Expect = 0.001 Identities = 83/441 (18%), Positives = 152/441 (34%), Gaps = 43/441 (9%) Query: 227 TPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPED 286 TP E+R T +S V++ + R +E+ +PTT + + Sbjct: 2981 TPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPIST 3040 Query: 287 LERGAAPVSAEAAAQGSIFLAGTGPPAPCPA-SSSILVNGSFLAASGSPAVLLNGGPVII 345 G+ P+++ + + + + P S+S +V + +++S +PA G + I Sbjct: 3041 PSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPA---EGTSMPI 3097 Query: 346 NGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPET 405 + + G G + T P A T ++ +D T EA S + Sbjct: 3098 STYSEGSTPLTGVPVST--------TPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTS 3149 Query: 406 KGAQVAAPGPALGEEVLG--PLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYP 463 +G + P+ G L P++ ++ +T P S Sbjct: 3150 EGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEG 3209 Query: 464 TGLSPTSPLLNLPQV--VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINS 521 T + ++P + + VP S L +P+ + A +S Sbjct: 3210 TSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEAS-------SS 3262 Query: 522 GVGVTALQLPSATAPGNFLLANPVSGSPI-VTGVAVQQGKIILTATFPTSMLV------S 574 +P++T + P++ P+ T VA + + T TS V S Sbjct: 3263 PPTAEGTSMPTSTPSEG---STPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQAS 3319 Query: 575 QVLPPAPGLALPLKPETAISVPEGGLPVAPSPAL-PEAHALGTLSAQQPPPAAATTSS-- 631 P A G ++P + S P + + +P + EA L T P +T + Sbjct: 3320 SSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASL 3379 Query: 632 -------TSLPFSPDSPGLLP 645 TS+P S S G P Sbjct: 3380 SPTTAEGTSIPTSSPSEGTTP 3400 Score = 42.0 bits (97), Expect = 0.002 Identities = 85/440 (19%), Positives = 146/440 (33%), Gaps = 32/440 (7%) Query: 222 GNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPC--KSESDGNPTTEDE 279 G PT + LT + ++ T P +E+ +P T + Sbjct: 3209 GTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEG 3268 Query: 280 SSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLN 339 +S G+ P+++ + ++ + T + PA +S V ++ AS SP Sbjct: 3269 TSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVT-TYSQASSSPP---- 3323 Query: 340 GGPVIINGLALGEAS-SLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEA 398 I +G ++ ++ S G LT + P S + ++ + T + D T EA Sbjct: 3324 ----IADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPV--DTSTPVTTSTEA 3377 Query: 399 QSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPA---VAAPQVVP 455 +G + P+ G L + ++ L PV + V Sbjct: 3378 SLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEAS 3437 Query: 456 LSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPAN 515 SP T L PTS + + T P A L+ P + P N Sbjct: 3438 SSPTIAEGTSL-PTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTN 3496 Query: 516 ----------VHLINSGVGVTAL-QLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILT 564 + +G G T L +P +T P A+ +S +P+ + V + Sbjct: 3497 SSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASS 3556 Query: 565 ATFPTSMLVSQVLPPAPG---LALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQ 621 + + ++ P+ G L L T ++ E P PS T S Sbjct: 3557 SPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNST 3616 Query: 622 PPPAAATTSSTSLPFSPDSP 641 P P T S P +P Sbjct: 3617 PTPPEVITLPMSTPSEVSTP 3636 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.311 0.131 0.383 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 38,193,600 Number of Sequences: 37866 Number of extensions: 2551341 Number of successful extensions: 31075 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 495 Number of HSP's successfully gapped in prelim test: 1517 Number of HSP's that attempted gapping in prelim test: 16603 Number of HSP's gapped (non-prelim): 11906 length of query: 739 length of database: 18,247,518 effective HSP length: 110 effective length of query: 629 effective length of database: 14,082,258 effective search space: 8857740282 effective search space used: 8857740282 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.8 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.