Guide to the Human Genome
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Search of human proteins with 40354216

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens]
         (739 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens]            1459   0.0  
gi|142976638 sine oculis homeobox homolog 4 [Homo sapiens]            313   5e-85
gi|219275578 SIX homeobox 2 [Homo sapiens]                            230   3e-60
gi|5174681 SIX homeobox 1 [Homo sapiens]                              223   4e-58
gi|4885597 sine oculis homeobox homolog 3 [Homo sapiens]              223   5e-58
gi|186910311 SIX homeobox 6 [Homo sapiens]                            211   1e-54
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         72   2e-12
gi|7662236 TSC22 domain family, member 2 [Homo sapiens]                69   2e-11
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    67   6e-11
gi|163965366 nascent polypeptide-associated complex alpha subuni...    67   8e-11
gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]       66   1e-10
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    65   2e-10
gi|160707881 formin 2 [Homo sapiens]                                   64   4e-10
gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]         63   9e-10
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    62   2e-09
gi|47132519 Ras association and pleckstrin homology domains 1 is...    62   2e-09
gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]                    62   3e-09
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              61   4e-09
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          60   6e-09
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          60   6e-09
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          60   6e-09
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             60   7e-09
gi|239742468 PREDICTED: double homeobox, 4-like [Homo sapiens]         60   7e-09
gi|194272172 double homeobox, 4 [Homo sapiens]                         60   7e-09
gi|163914392 glioma tumor suppressor candidate region gene 1 [Ho...    60   7e-09
gi|194272217 double homeobox, 4-like [Homo sapiens]                    60   7e-09
gi|194272216 double homeobox, 4-like [Homo sapiens]                    60   7e-09
gi|194272215 double homeobox, 4-like [Homo sapiens]                    60   7e-09
gi|194272192 double homeobox, 4-like [Homo sapiens]                    60   7e-09
gi|91982772 mucin 17 [Homo sapiens]                                    60   1e-08

>gi|40354216 sine oculis homeobox homolog 5 [Homo sapiens]
          Length = 739

 Score = 1459 bits (3776), Expect = 0.0
 Identities = 739/739 (100%), Positives = 739/739 (100%)

Query: 1   MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAG 60
           MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAG
Sbjct: 1   MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAG 60

Query: 61  AEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERL 120
           AEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERL
Sbjct: 61  AEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERL 120

Query: 121 RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRAL 180
           RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRAL
Sbjct: 121 RGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRAL 180

Query: 181 GAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGL 240
           GAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGL
Sbjct: 181 GAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGL 240

Query: 241 SLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA 300
           SLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA
Sbjct: 241 SLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA 300

Query: 301 QGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLL 360
           QGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLL
Sbjct: 301 QGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLL 360

Query: 361 LTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEE 420
           LTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEE
Sbjct: 361 LTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEE 420

Query: 421 VLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP 480
           VLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP
Sbjct: 421 VLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP 480

Query: 481 TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL 540
           TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL
Sbjct: 481 TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL 540

Query: 541 LANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGL 600
           LANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGL
Sbjct: 541 LANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGL 600

Query: 601 PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA 660
           PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA
Sbjct: 601 PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA 660

Query: 661 AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEA 720
           AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEA
Sbjct: 661 AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEA 720

Query: 721 EAKVLTQLQSVPVEEPLEL 739
           EAKVLTQLQSVPVEEPLEL
Sbjct: 721 EAKVLTQLQSVPVEEPLEL 739


>gi|142976638 sine oculis homeobox homolog 4 [Homo sapiens]
          Length = 781

 Score =  313 bits (801), Expect = 5e-85
 Identities = 190/370 (51%), Positives = 232/370 (62%), Gaps = 37/370 (10%)

Query: 5   PAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGP 64
           P  P+  P   G+A  AAA    EE                AAAAAGA A      +E  
Sbjct: 45  PPAPAPFPLEPGDAATAAARVSGEEGAV-------------AAAAAGAAADQVQLHSELL 91

Query: 65  GSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSD 124
           G          AA+   T L FSP+ VACVCEAL Q G+  RL+RFL +LP ++ LRG++
Sbjct: 92  GR-----HHHAAAAAAQTPLAFSPDHVACVCEALQQGGNLDRLARFLWSLPQSDLLRGNE 146

Query: 125 PVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVD 184
            +L+ARALVAF +G Y ELY +LES  F +A+H  LQ L+ +ARY EAERARGR LGAVD
Sbjct: 147 SLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVD 206

Query: 185 KYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQ 244
           KYRLR+KFPLP+TIWDGEETVYCFKE+SR ALK  Y+ NRYP+P EKR LA +TGLSLTQ
Sbjct: 207 KYRLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQ 266

Query: 245 VSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGS- 303
           VSNWFKNRRQRDR  +      KSESDGNP+TEDESS+  EDL       S++     S 
Sbjct: 267 VSNWFKNRRQRDRNPS--ETQSKSESDGNPSTEDESSKGHEDLSPHPLSSSSDGITNLSL 324

Query: 304 ------IFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNG-----GP--VIINGLAL 350
                 +++   G      +SS +L+NGS + AS SP V LNG     GP  VI+NGL +
Sbjct: 325 SSHMEPVYMQQIGNAKISLSSSGVLLNGSLVPASTSP-VFLNGNSFIQGPSGVILNGLNV 383

Query: 351 G--EASSLGP 358
           G  +A +L P
Sbjct: 384 GNTQAVALNP 393


>gi|219275578 SIX homeobox 2 [Homo sapiens]
          Length = 291

 Score =  230 bits (587), Expect = 3e-60
 Identities = 135/289 (46%), Positives = 173/289 (59%), Gaps = 31/289 (10%)

Query: 86  FSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYR 145
           F+ EQVACVCE L Q G+  RL RFL +LP  E L  ++ VL+A+A+VAF RG + ELY+
Sbjct: 9   FTQEQVACVCEVLQQGGNIERLGRFLWSLPACEHLHKNESVLKAKAVVAFHRGNFRELYK 68

Query: 146 LLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETV 205
           +LES  F   +HA LQ L+L+A Y EAE+ RGR LGAV KYR+R+KFPLP++IWDGEET 
Sbjct: 69  ILESHQFSPHNHAKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETS 128

Query: 206 YCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAP 265
           YCFKE+SR+ L+  Y  N YP+P EKR LA  TGL+ TQVSNWFKNRRQRDR        
Sbjct: 129 YCFKEKSRSVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRA------- 181

Query: 266 CKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNG 325
             +E+      E+ +S S   L      V   +  + +        P+  P  S      
Sbjct: 182 --AEAKERENNENSNSNSHNPLNGSGKSVLGSSEDEKT--------PSGTPDHS------ 225

Query: 326 SFLAASGSPAVLLNGGPVIINGL-ALGE--ASSLGPLLLTGGGGAPPPQ 371
                S SPA+LL+  P  +  L +LG     S  P+ + GGGGA P Q
Sbjct: 226 -----SSSPALLLSPPPPGLPSLHSLGHPPGPSAVPVPVPGGGGADPLQ 269


>gi|5174681 SIX homeobox 1 [Homo sapiens]
          Length = 284

 Score =  223 bits (569), Expect = 4e-58
 Identities = 120/248 (48%), Positives = 159/248 (64%), Gaps = 12/248 (4%)

Query: 86  FSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYR 145
           F+ EQVACVCE L Q G+  RL RFL +LP  + L  ++ VL+A+A+VAF RG + ELY+
Sbjct: 9   FTQEQVACVCEVLQQGGNLERLGRFLWSLPACDHLHKNESVLKAKAVVAFHRGNFRELYK 68

Query: 146 LLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETV 205
           +LES  F   +H  LQ L+L+A Y EAE+ RGR LGAV KYR+R+KFPLP+TIWDGEET 
Sbjct: 69  ILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETS 128

Query: 206 YCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAP 265
           YCFKE+SR  L+  Y  N YP+P EKR LA  TGL+ TQVSNWFKNRRQRDR  A     
Sbjct: 129 YCFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDR--AAEAKE 186

Query: 266 CKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNG 325
            ++  + N ++  ++  SP +   G  P+ + +  + S       PP     +S +L+ G
Sbjct: 187 RENTENNNSSSNKQNQLSPLE---GGKPLMSSSEEEFS-------PPQSPDQNSVLLLQG 236

Query: 326 SFLAASGS 333
           +   A  S
Sbjct: 237 NMGHARSS 244


>gi|4885597 sine oculis homeobox homolog 3 [Homo sapiens]
          Length = 332

 Score =  223 bits (568), Expect = 5e-58
 Identities = 136/292 (46%), Positives = 170/292 (58%), Gaps = 23/292 (7%)

Query: 44  GEAAAAAGAGAGAAAAGAEGPGSPGVPGS--PPEAAS--EPPTGLRFSPEQVACVCEALL 99
           G A   +G G GA   GA G G  G  GS  PPE  S  + PT L FSPEQVA VCE L 
Sbjct: 42  GGAGGGSGGGNGAGGGGAGGAGGGGGGGSRAPPEELSMFQLPT-LNFSPEQVASVCETLE 100

Query: 100 QAGHAGRLSRFLGALPPA----ERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAA 155
           + G   RL RFL +LP A    E +   + +LRARA+VAF  G + +LY +LE+  F   
Sbjct: 101 ETGDIERLGRFLWSLPVAPGACEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKE 160

Query: 156 HHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAA 215
            H  LQ ++L A Y EAE+ RGR LG VDKYR+RKKFPLP+TIWDGE+  +CFKER+R+ 
Sbjct: 161 SHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSL 220

Query: 216 LKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAG---------GGAPC 266
           L+  Y  + YP P +KR LA  TGL+ TQV NWFKNRRQRDR  A          G +  
Sbjct: 221 LREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQHQAIGPSGM 280

Query: 267 KSESD-GNPTTEDESSRSPEDLERGAAPVSA--EAAAQGSIFLAGTGPPAPC 315
           +S ++ G PT    S+ SP         VS+  E A  G+  L+ T   + C
Sbjct: 281 RSLAEPGCPT--HGSAESPSTAASPTTSVSSLTERADTGTSILSVTSSDSEC 330


>gi|186910311 SIX homeobox 6 [Homo sapiens]
          Length = 246

 Score =  211 bits (538), Expect = 1e-54
 Identities = 112/207 (54%), Positives = 134/207 (64%), Gaps = 16/207 (7%)

Query: 84  LRFSPEQVACVCEALLQAGHAGRLSRFLGALPPA----ERLRGSDPVLRARALVAFQRGE 139
           L FSP+QVA VCE L ++G   RL RFL +LP A    E L  ++ VLRARA+VAF  G 
Sbjct: 7   LNFSPQQVAGVCETLEESGDVERLGRFLWSLPVAPAACEALNKNESVLRARAIVAFHGGN 66

Query: 140 YAELYRLLESRPFPAAHHAFLQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIW 199
           Y ELY +LE+  F    HA LQ L+L A Y EAE+ RGR LG VDKYR+RKKFPLP+TIW
Sbjct: 67  YRELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIW 126

Query: 200 DGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTG 259
           DGE+  +CFKER+R  L+  Y  + YP P +KR LA  TGL+ TQV NWFKNRRQRDR  
Sbjct: 127 DGEQKTHCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAA 186

Query: 260 A------------GGGAPCKSESDGNP 274
           A            G G   ++E DG P
Sbjct: 187 AAKNRLQQQVLSQGSGRALRAEGDGTP 213


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 103/363 (28%), Positives = 140/363 (38%), Gaps = 74/363 (20%)

Query: 358  PLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLE-----EAQSEAPET----KGA 408
            P  L G   +P P P+    +   +S V  P +  + +       A + AP T       
Sbjct: 1404 PSSLPGPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPL 1463

Query: 409  QVAAPGPALGEEVLGPLAQVV---PGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTG 465
             V+A GPAL   V  PLA VV   PGPP+ A    P G  P+ +A   + L+  P   + 
Sbjct: 1464 TVSASGPALLTSVTPPLAPVVPAAPGPPSLA----PSGASPSASA-LTLGLATAPSLSSS 1518

Query: 466  LSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGV 525
             +P  PLL    + PTS  V               PG    VA A  P         V  
Sbjct: 1519 QTPGHPLL----LAPTSSHV---------------PGLNSTVAPACSPVL-------VPA 1552

Query: 526  TALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLAL 585
            +AL  P  +AP      NP          A  Q  ++  A+  +  L + + P A     
Sbjct: 1553 SALASPFPSAP------NP----------APAQASLLAPASSASQALATPLAPMA----- 1591

Query: 586  PLKPETAISVPEGGLPVAPSPAL-PEAHALGTL-SAQQPPPAAATTSSTSLPFSPDSPGL 643
               P+TAI  P    P+AP P L P   A   L S+Q P P  A +S+     +  SP  
Sbjct: 1592 --APQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVP 1649

Query: 644  LPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEA---EKGLGTQAPHTVLRLPDPD 700
             P     P     + PA VP   + L   A T+ L  A      LG  +P   L L   +
Sbjct: 1650 APTPVLAPSSTQTMLPAPVP---SPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGN 1706

Query: 701  PEG 703
            P+G
Sbjct: 1707 PQG 1709



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 102/392 (26%), Positives = 150/392 (38%), Gaps = 66/392 (16%)

Query: 268  SESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP--PAPCPASSSILVNG 325
            S++ G+P     +S     L    AP  +      S  LA   P  P P PA +S+L   
Sbjct: 1518 SQTPGHPLLLAPTSSHVPGLNSTVAPACSPVLVPASA-LASPFPSAPNPAPAQASLLAP- 1575

Query: 326  SFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLV 385
               A+S S A+     P     +A  + + L P        APP  P P          V
Sbjct: 1576 ---ASSASQALATPLAP-----MAAPQTAILAP------SPAPPLAPLP----------V 1611

Query: 386  LDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATF-PLP-PG 443
            L P  G   +  A S+ P    A  + PG +L      P    V  P +  T  P P P 
Sbjct: 1612 LAPSPGAAPVL-ASSQTPVPVMAPSSTPGTSLASASPVPAPTPVLAPSSTQTMLPAPVPS 1670

Query: 444  PVPAVAAPQVVPLSPP-----------------PGYPTGLSPTSPLLNLP--QVVPT-SQ 483
            P+P+ A+ Q + L+P                   G P G  PT  L   P   +VPT +Q
Sbjct: 1671 PLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPFPTQTLSLTPASSLVPTPAQ 1730

Query: 484  VVTLPQA--VGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLL 541
             ++L     +GP Q L+  P  P+  A+  GPA  H +      ++  L +  +     L
Sbjct: 1731 TLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTL 1790

Query: 542  ANPVSGSPIVT-GVAVQQGKIILTAT--FPTSMLVSQVLPPAPGLALPLKPETAISVPE- 597
                S +P+ T G A  Q   +  A+   P S   S V+  +    LP+   + + V + 
Sbjct: 1791 ----SPAPVPTLGPAAAQTLALAPASTQSPASQASSLVVSASGAAPLPVTMVSRLPVSKD 1846

Query: 598  --GGLPVAPSPALPEAHAL---GTLSAQQPPP 624
                L +   P  P + A    G    +QPPP
Sbjct: 1847 EPDTLTLRSGPPSPPSTATSFGGPRPRRQPPP 1878



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 124/487 (25%), Positives = 173/487 (35%), Gaps = 101/487 (20%)

Query: 293  PVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGE 352
            P +A   +  +     T  PAP PA   ++++    A        L  G V+    ++G+
Sbjct: 1141 PAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQAR-------LPSGEVV----SIGQ 1189

Query: 353  ASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDP---------QTGEVRLEEAQ---- 399
             +SL    +   GG+ P     QG   T T   +           Q   V L  A     
Sbjct: 1190 LASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHH 1249

Query: 400  --SEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVP-- 455
              S+       Q  AP P       GP    V    T +T P P G    +AA QV P  
Sbjct: 1250 LISQPAHVALIQAVAPTP-------GPTPVSVLPSSTPSTTPAPTGLSLPLAANQVPPTM 1302

Query: 456  ------------------LSPPPGYPTGLSPTSPLLNLPQV-----------VPTSQVVT 486
                              L+P P  P   +P  P   LP V           +PT  + T
Sbjct: 1303 VNNTGVVKIVVRQAPRDGLTPVP--PLAPAPRPPSSGLPAVLNPRPTLTPGRLPTPTLGT 1360

Query: 487  ------LPQAVGPLQLLAAGPGSPVKVAA-AAGPANV----HLINSGVGVTALQLPSATA 535
                   P  V PL  L   P   V  +A  A P  +    H+ +S  G  +  +P    
Sbjct: 1361 ARAPMPTPTLVRPLLKLVHSPSPEVSASAPGAAPLTISSPLHVPSSLPGPASSPMP---I 1417

Query: 536  PGNFLLANPVSGS---PIVTGVAVQQGKII-LTATFPTSMLVS---QVLPPAPGLALPLK 588
            P +  LA+PVS +   P+ + + +     +   A+ P ++ +S    V    P L   + 
Sbjct: 1418 PNSSPLASPVSSTVSVPLSSSLPISVPTTLPAPASAPLTIPISAPLTVSASGPALLTSVT 1477

Query: 589  PETAISVPEGGLP--VAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDS---PGL 643
            P  A  VP    P  +APS A P A AL    A  P  +++ T    L  +P S   PGL
Sbjct: 1478 PPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGL 1537

Query: 644  LPNF-PAPPPEGLMLSPAAVPVWSAGLELSAGTEGLL---EAEKGLGT-----QAPHTVL 694
                 PA  P  +  S  A P  SA     A    L     A + L T      AP T +
Sbjct: 1538 NSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAI 1597

Query: 695  RLPDPDP 701
              P P P
Sbjct: 1598 LAPSPAP 1604



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 67/272 (24%), Positives = 95/272 (34%), Gaps = 48/272 (17%)

Query: 368  PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVL-GPLA 426
            PPP+P P      +    +  Q G   +      AP         PGP L  +   GP+ 
Sbjct: 983  PPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRPPPGPELSAQPTPGPVP 1042

Query: 427  QVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLL-NLPQVVPTSQVV 485
            QV+P     +  P         A P ++P S PPG P  L P  P   +LPQV+P+   V
Sbjct: 1043 QVLPASLMVSASP---------AGPPLIPASRPPG-PVLLPPLQPNSGSLPQVLPSPLGV 1092

Query: 486  TLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPV 545
                +  P   L+  P  P  V                     +L  A  PG+  L  P+
Sbjct: 1093 LSGTSRPPTPTLSLKPTPPAPV---------------------RLSPAPPPGSSSLLKPL 1131

Query: 546  SGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPG-LALPLKPETAISVPEGGLPVAP 604
            +  P   G          T+T   +   + V  P P    L L P+    +P G      
Sbjct: 1132 TVPP---GYTFPPAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSG------ 1182

Query: 605  SPALPEAHALGTLSAQQPPPAAATTSSTSLPF 636
                 E  ++G L++    P A    S  L F
Sbjct: 1183 -----EVVSIGQLASLAQRPVANAGGSKPLTF 1209



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 81/320 (25%), Positives = 122/320 (38%), Gaps = 73/320 (22%)

Query: 367  APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426
            AP P+P+P  A     +LV  P +  V                ++AP P     V     
Sbjct: 2440 APRPRPTPASAPAAIPALVPVPVSAPV---------------PISAPNPITILPV----- 2479

Query: 427  QVVPGPPTAATFPLPPGPVPAVAAPQVVPL---------SPPPGYPTGLSPTSPLLNLPQ 477
             ++P PP       PP  +P  ++P   P          +PPP     ++P+SPLL  P 
Sbjct: 2480 HILPSPP-------PPSQIPPCSSPACTPPPACTPPPAHTPPPAQTCLVTPSSPLLLGPP 2532

Query: 478  VVPTSQVVT-LPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAP 536
             VP S  VT LP  + P   L A         A A P ++ L  + V  +     S   P
Sbjct: 2533 SVPISASVTNLPLGLRPEAELCA--------QALASPESLEL--ASVASSETSSLSLVPP 2582

Query: 537  GNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPE--TAIS 594
             + L   PV+    V  + V +  + LT + P+  L +  +P       P   E  T   
Sbjct: 2583 KDLL---PVA----VEILPVSEKNLSLTPSAPSLTLEAGSIPNGQEQEAPDSAEGTTLTV 2635

Query: 595  VPEG-GLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPD------SPGLLPNF 647
            +PEG  LP+  S    E++ L      + PP+AA+      P   D      +    P  
Sbjct: 2636 LPEGEELPLCVS----ESNGL------ELPPSAASDEPLQEPLEADRTSEELTEAKTPTS 2685

Query: 648  PAPPPEGLMLSPAAVPVWSA 667
                P+ L+ +  A P  S+
Sbjct: 2686 SPEKPQELVTAEVAAPSTSS 2705



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 81/307 (26%), Positives = 115/307 (37%), Gaps = 47/307 (15%)

Query: 209  KERSRAALKACYRGNRYP-TPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGG-APC 266
            + R+ A ++   +G   P  P   + L  L G  +T V      RR+R + GA     P 
Sbjct: 2721 RRRTSADVEIRGQGTGRPGQPPGPKVLRKLPGRLVTVVEEKELVRRRRQQRGAASTLVPG 2780

Query: 267  KSESDGNPTTEDESSRS-PEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILV-- 323
             SE+  +P +    S S PE       P   EAA   S+    T P  P  A   I +  
Sbjct: 2781 VSETSASPGSPSVRSMSGPESSPPIGGP--CEAAPSSSL---PTPPQQPFIARRHIELGV 2835

Query: 324  ---------NGSFLAASGSPAVLLNGGPVIIN------GLALGEASSLGPLLLTGGGGAP 368
                     +G+ LA +        G P   N      G  + EA S     L G     
Sbjct: 2836 TGGGSPENGDGALLAITPPAVKRRRGRPPKKNRSPADAGRGVDEAPSS---TLKGKTNGA 2892

Query: 369  PPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQ-VAAPGPALGEEVLGPLAQ 427
             P P P+      T +V DP      LE      P+  G Q V  P P     +L P+ +
Sbjct: 2893 DPVPGPE------TLIVADPV-----LEPQLIPGPQPLGPQPVHRPNP-----LLSPVEK 2936

Query: 428  VVPG-PPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVT 486
               G PP A   P+P G + +         + PP +P+ L+P  PLL  P     + V T
Sbjct: 2937 RRRGRPPKARDLPIP-GTISSAGDGNSESRTQPPPHPSPLTPLPPLLVCPTATVANTVTT 2995

Query: 487  LPQAVGP 493
            +  +  P
Sbjct: 2996 VTISTSP 3002



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 24/72 (33%), Positives = 32/72 (44%), Gaps = 6/72 (8%)

Query: 370 PQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVL-GPLAQV 428
           P P+       +T +V D  TG   +  A S +P + GA   +P     +  L GP    
Sbjct: 5   PSPAHPQLPVLQTQMVSDGMTGSNPVSPASSSSPASSGAGGISPQHIAQDSSLDGP---- 60

Query: 429 VPGPPTAATFPL 440
            PGPP  AT PL
Sbjct: 61  -PGPPDGATVPL 71



 Score = 30.8 bits (68), Expect = 4.7
 Identities = 51/184 (27%), Positives = 72/184 (39%), Gaps = 32/184 (17%)

Query: 287  LERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIIN 346
            L     P    AAAQ ++ LA     +P   +SS++V+ S   A+  P  +++  PV  +
Sbjct: 1790 LSPAPVPTLGPAAAQ-TLALAPASTQSPASQASSLVVSAS--GAAPLPVTMVSRLPVSKD 1846

Query: 347  G---LALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAP 403
                L L       P   T  GG   P+P  Q     ++   LD    E + +  +SE  
Sbjct: 1847 EPDTLTLRSGPPSPPSTATSFGG---PRPRRQPPPPPRSPFYLDSL--EEKRKRQRSERL 1901

Query: 404  ETKGAQVAAPG---PALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPP 460
            E       A G   P  G EVL              T P P      VA+P + P SP P
Sbjct: 1902 ERIFQLSEAHGALAPVYGTEVLD-----------FCTLPQP------VASP-IGPRSPGP 1943

Query: 461  GYPT 464
             +PT
Sbjct: 1944 SHPT 1947


>gi|7662236 TSC22 domain family, member 2 [Homo sapiens]
          Length = 780

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 93/333 (27%), Positives = 124/333 (37%), Gaps = 62/333 (18%)

Query: 366 GAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPL 425
           G P P P P G +  ++S  L P  G      A    P    AQ + P  A      GP 
Sbjct: 272 GQPQPPPPPVGGAVAQSSAPLPPFPG-----AATGPQPMMAAAQPSQPQGA------GPG 320

Query: 426 AQVVPGPPTAAT-----FPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVP 480
            Q +  PPT  T       LPP P PAV AP          YP    P  P  +L  V P
Sbjct: 321 GQTL--PPTNVTLAQPAMSLPPQPGPAVGAP-AAQQPQQFAYP---QPQIPPGHLLPVQP 374

Query: 481 TSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTA----LQLPSATAP 536
           + Q   L Q V  LQ     P  P    AAA PA    +  G G  A     QL  A++ 
Sbjct: 375 SGQSEYLQQHVAGLQ--PPSPAQPSSTGAAASPATAATLPVGTGQNASSVGAQLMGASSQ 432

Query: 537 GNFLLA---NPVSGSPIV----TGV-AVQQGKIILTATFPTSMLVSQVLPPAPGLALPLK 588
            +  +A    P  G  +     TGV     G ++     P      Q +PP         
Sbjct: 433 PSEAMAPRTGPAQGGQVAPCQPTGVPPATVGGVVQPCLGPAGAGQPQSVPP--------- 483

Query: 589 PETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFP 648
           P+   S P   +P  P   +P    +  + A  P P+  + S+TS+         +PN P
Sbjct: 484 PQMGGSGPLSAVPGGPHAVVP---GVPNVPAAVPAPSVPSVSTTSV--------TMPNVP 532

Query: 649 APPPEGLMLSP------AAVPVWSAGLELSAGT 675
           AP  +   LS       ++  +   GL L+ GT
Sbjct: 533 APLAQSQQLSSHTPVSRSSSIIQHVGLPLAPGT 565



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 94/371 (25%), Positives = 122/371 (32%), Gaps = 78/371 (21%)

Query: 314 PCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSL---------------GP 358
           P   S ++L++G   AA+ +PA   NGG V+      G  +S                GP
Sbjct: 81  PGTVSPNLLLDGQLAAAAAAPA---NGGGVVSARSVSGALASTLAAAATSAPAPGAPGGP 137

Query: 359 LLLTGGGG---APPPQPSPQGASETKTSLVLDPQTGE---------VRLEEAQSEAPETK 406
            L     G   A P QP P   S     + LD  +GE         +   E  S++    
Sbjct: 138 QLAGSSAGPVTAAPSQP-PTTCSSRFRVIKLDHGSGEPYRRGRWTCMEYYERDSDSSVLT 196

Query: 407 GA-----------QVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVP 455
            +           Q A     LG    G    VV      A  P   G   ++ A   +P
Sbjct: 197 RSGDCIRHSSTFDQTAERDSGLG--ATGGSVVVVVASMQGAHGP-ESGTDSSLTAVSQLP 253

Query: 456 LSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPAN 515
            S     PT   P S  +  PQ  P      + Q+  PL         P  + AAA P+ 
Sbjct: 254 PSEKMSQPTPAQPQSFSVGQPQPPPPPVGGAVAQSSAPLPPFPGAATGPQPMMAAAQPSQ 313

Query: 516 VHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQ 575
                 G G     LP    P N  LA P    P   G AV           P +    Q
Sbjct: 314 ----PQGAGPGGQTLP----PTNVTLAQPAMSLPPQPGPAVGA---------PAAQQPQQ 356

Query: 576 VLPPAPGLALPLKPETAISVPEGG-LPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSL 634
              P P             +P G  LPV PS    ++  L    A   PP+ A  SST  
Sbjct: 357 FAYPQP------------QIPPGHLLPVQPS---GQSEYLQQHVAGLQPPSPAQPSSTGA 401

Query: 635 PFSPDSPGLLP 645
             SP +   LP
Sbjct: 402 AASPATAATLP 412



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 22/73 (30%), Positives = 29/73 (39%), Gaps = 8/73 (10%)

Query: 6   AEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGPG 65
           A  +A PA GG  V+A + +          L +  AA   +A A GA  G   AG+    
Sbjct: 95  AAAAAAPANGGGVVSARSVSGA--------LASTLAAAATSAPAPGAPGGPQLAGSSAGP 146

Query: 66  SPGVPGSPPEAAS 78
               P  PP   S
Sbjct: 147 VTAAPSQPPTTCS 159


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 67.0 bits (162), Expect = 6e-11
 Identities = 85/311 (27%), Positives = 116/311 (37%), Gaps = 58/311 (18%)

Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426
           +PP  PS    S+   SL   P      L+   S       +  A P P     +  P  
Sbjct: 682 SPPVSPSATPPSQAPPSLAAPP------LQVPPSPPASPPMSPSATPPPQAPPPLAAPPL 735

Query: 427 QVVPGPPTAATFPLPPGPVPAVAAPQVV---PLSPPPGYPTGLSPTSPLLNLPQVVPTSQ 483
           QV P PP  A+ P+ P   P    P ++   PL  PP  P  L P SPL   P   P + 
Sbjct: 736 QVPPSPP--ASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASL-PMSPLAKPPPQAPPA- 791

Query: 484 VVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLAN 543
                 A  PLQ L + P S    A  +                   PSA+ P + L   
Sbjct: 792 -----LATPPLQALPSPPASFPGQAPFS-------------------PSASLPMSPLATP 827

Query: 544 PVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVA 603
           P    P++    +Q    +  +   +  L +   PP PG      P+T++S P   L +A
Sbjct: 828 PPQAPPVLAAPLLQ----VPPSPPASPTLQAPRRPPTPG------PDTSVSGPRLTLALA 877

Query: 604 PSPALPEAHA-LGTLSAQQPPPAAATTSSTSLP-----FSPDSPGLLPNFPAPPPEGLML 657
           P P  P + +   TLS   P  A  ++S+TS P     +     G     P P  E    
Sbjct: 878 PGPPPPPSRSPSSTLSG--PDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAAC 935

Query: 658 SPAAVPVWSAG 668
            PAA   WS G
Sbjct: 936 HPAA---WSRG 943



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 116/468 (24%), Positives = 160/468 (34%), Gaps = 83/468 (17%)

Query: 292 APVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGL--- 348
           +P   +A+       A T P +P   +   L     L  S SPAV     P+ I+ L   
Sbjct: 433 SPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQAL 492

Query: 349 -ALGEASSLGPL-------LLTGGGGAPPPQPSPQGASETKT-----SLVLDP-QTGEVR 394
            +L   S   PL       L T    APP   +P  +  T       SL   P QT    
Sbjct: 493 SSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAP 552

Query: 395 LEEAQSEAPETKG-------------------AQVAAPGPALGEEVLGPLAQVVPGPPTA 435
           L     E P                       + +A P P     +  P  Q +P PP +
Sbjct: 553 LTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLS 612

Query: 436 ATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQA----- 490
                PP   P +A P   PL  PP  P    P SPL       P +  V L QA     
Sbjct: 613 PLATPPPQAPPXLALP---PLQAPPS-PPASPPLSPLATPSPQAPNALAVHLLQAPFSPP 668

Query: 491 -VGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSP 549
              P+Q   + P SP    +A  P+      +   +     P A+ P +     P    P
Sbjct: 669 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAPP 728

Query: 550 IVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETA--------ISVPEGGLP 601
            +    +Q                   +PP+P  + P+ P           ++ P   +P
Sbjct: 729 PLAAPPLQ-------------------VPPSPPASPPMSPSATPPPRVPPLLAAPPLQVP 769

Query: 602 VAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDS-PGLLPNFPAPPPEGLMLSPA 660
            +P  +LP +         Q PPA AT    +LP  P S PG     P  P   L +SP 
Sbjct: 770 PSPPASLPMSPL--AKPPPQAPPALATPPLQALPSPPASFPG---QAPFSPSASLPMSPL 824

Query: 661 AVPVWSAGLELSAGTEGLLEAEKGLGT-QAPHTVLRLPDPDPEGLLLG 707
           A P   A   L+A    +  +     T QAP    R P P P+  + G
Sbjct: 825 ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR---RPPTPGPDTSVSG 869



 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 86/364 (23%), Positives = 124/364 (34%), Gaps = 35/364 (9%)

Query: 362 TGGGGAPPPQPSPQGASETKTSLVL--DPQTGEVRLEEAQSEAPETKGAQVAAP------ 413
           + GGG   P      +S T  S      P         A    P+ KG Q   P      
Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP 288

Query: 414 ----GPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPT 469
                PALG     PLA   P P      P+PP    A   P  +P SPP   P  L+P 
Sbjct: 289 RKDAAPALGPLSSSPLA--TPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPP 346

Query: 470 SPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQ 529
           S     P   P+ Q +  P A  P Q   +    P++   +        +   +   +LQ
Sbjct: 347 S-----PSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQ 401

Query: 530 LPSATAPGNFLLANPVSGSPIVTG------VAVQQGKIILTATFPTSMLVSQVLPPAPGL 583
            P +    + L A    GSP +        ++ +Q +  LT+    +       P    L
Sbjct: 402 APPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPL 461

Query: 584 ALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGL 643
           +LP  P    S+     P++    +    AL +L++  P    A  SS  +P       L
Sbjct: 462 SLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASHSP---QAPLSSLIMPPLETQSSL 518

Query: 644 LPNFPAPPPEGLMLSP-------AAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRL 696
            P     PP  L   P       A  P+ +A   L+               QAP + L  
Sbjct: 519 APPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTT 578

Query: 697 PDPD 700
           P P+
Sbjct: 579 PPPE 582



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 117/461 (25%), Positives = 160/461 (34%), Gaps = 97/461 (21%)

Query: 290 GAAPVSAEAAAQGSIFLAGTGPPAPCP--ASSSILVNGSFLAASGSPAVLLNGGPVIING 347
           GAA  +  A A G +     G P P P    +++ V G+  A    P     GG   I G
Sbjct: 11  GAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGG---IGG 67

Query: 348 LALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKG 407
             + E+             AP   P+    + ++      P +G     E    A  T  
Sbjct: 68  ATIPES-------------APRAGPTRSAGTSSRNPASRPPASGR---GERAPPAKNTSP 111

Query: 408 AQVAAPGPALGEEVLGPLAQ----------VVPGPPTAA--------------TFPLPPG 443
             V++PG A G    GPL Q          V  G  T A              + P P  
Sbjct: 112 GPVSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGT 171

Query: 444 PVPAVA---------------APQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488
           P PA+A               AP   P  P  G    +S  S         P+      P
Sbjct: 172 PSPAMARRSRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSAS---EHSTTEPSPAARRRP 228

Query: 489 QAVGPLQLLA----AGPGSPVKVAAAAGP-------ANVHLIN-SGVGVTALQLPSATAP 536
            A G LQ  A    +   +P+   A +GP       A  H       G+ AL+ P  T P
Sbjct: 229 SAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPP 288

Query: 537 GNFL--LANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLA--LPLKPETA 592
                    P+S SP+ T          +      +  +   LPP+P LA  LPL P + 
Sbjct: 289 RKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSP 348

Query: 593 ISVPEGGLPVAPS-PALPEAHALGTLSA--QQPPPAAATTSSTSLPFSPDSPGLLPNFPA 649
            + P   L   PS PA P + A  +++    Q PP+  T     +P S  SP L     A
Sbjct: 349 SAPP--SLQTLPSPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSL----QA 402

Query: 650 PPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAP 690
           PP      SP A+    A   L + T   L+A     T +P
Sbjct: 403 PP------SPLALSSLQATTSLGSPT---LQATHSFLTMSP 434


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 118/453 (26%), Positives = 161/453 (35%), Gaps = 52/453 (11%)

Query: 272  GNPTTEDESSRSPED-----LERGA--APVSAEAAAQGSIFLAGTGPP--APC-PASSSI 321
            G PTT   +  SP+        +GA   P +   + +G +    T PP  AP  PA++  
Sbjct: 1124 GAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGL---ATPPPKGAPTTPAATPP 1180

Query: 322  LVNGSFLAAS--GSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQ-----PSP 374
               G     S  G+P       P    GLA            T     P P+     PSP
Sbjct: 1181 SPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT---TPAATPPSPKGGLATPSP 1237

Query: 375  QGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQV--AAPGPALGEEVLGPLAQVVPGP 432
            +GA  T  +    P+ G           P  KGA    AA  P+L   +  P  +  P P
Sbjct: 1238 KGAPTTPAATPPSPKGGPA--------TPPPKGAPTPPAATPPSLKGGLATPPHKGAPNP 1289

Query: 433  PTAATFPLPPGPVPAVAAPQVVPLSPP--PGYPTGLSPTSPLLNLPQVVPTSQVVTLPQA 490
              A   P  P   PA + P+  P  P   P  P G   T P    P+  PT   VT P  
Sbjct: 1290 --AVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPP----PKGAPTPPAVTPPSP 1343

Query: 491  VGPLQLLAAGP---GSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSG 547
             G   L A  P   G P   ++  GP       S  G  A+  PS               
Sbjct: 1344 KGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPT 1403

Query: 548  SPIVTGVAVQQGKII-LTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSP 606
            SP V  ++ ++     +T     +     + PPA    + LK   A S P+GG     S 
Sbjct: 1404 SPAVIPLSPKKAPATPVTREGAATPSKGDLTPPAV-TPVSLKKAPATSAPKGGPATPSSK 1462

Query: 607  ALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLL--PNFPAPPPEGLMLSPAAVPV 664
              P   A+   S ++PP      +S+S   +P +P  +  P  PA  P     SP  VP 
Sbjct: 1463 GDPTLPAVTPPSPKEPPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPS----SPKEVPA 1518

Query: 665  WSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLP 697
              +           L ++K   T AP   L  P
Sbjct: 1519 TPSSRRDPIAPTATLLSKKTPATLAPKEALIPP 1551



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 114/457 (24%), Positives = 169/457 (36%), Gaps = 75/457 (16%)

Query: 227  TPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPED 286
            TP  +   AT +   LT  +    + ++   T A  G P    S G+PT    +  SP++
Sbjct: 1418 TPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKE 1477

Query: 287  ------LERGAAPVSAEA--AAQGSIFLAGTGPPAP--CPASSSI----LVNGSFLAASG 332
                  +   ++P  A A  A  G+  L    P +P   PA+ S     +   + L +  
Sbjct: 1478 PPAPKQVATSSSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKK 1537

Query: 333  SPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGE 392
            +PA L              + + + P +        P  P+P+ A  T +S         
Sbjct: 1538 TPATLAP------------KEALIPPAMTVPSPKKTPAIPTPKEAPATPSS--------- 1576

Query: 393  VRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP--LPPGPV--PAV 448
               +EA S    T      AP P   +E+L P A   P P  A T P   PP P   PA 
Sbjct: 1577 ---KEASSPPAVTPSTYKGAPSP---KELLIPPAVTSPSPKEAPTPPAVTPPSPEKGPAT 1630

Query: 449  AAPQVVPLSPPPGYPTGL--SPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVK 506
             AP+  P SPP   P+ L  SPTS     P  V      T+PQA   L     GP +  +
Sbjct: 1631 PAPKGTPTSPPV-TPSSLKDSPTS-----PASVTCKMGATVPQASKGLP-AKKGPTALKE 1683

Query: 507  VAAAAGPANVHLINSGVGV-TALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTA 565
            V  A  P +  +I +        +  SAT+P       P+   P     +  +G +   A
Sbjct: 1684 VLVAPAPESTPIITAPTRKGPQTKKSSATSP-------PICPDPSAKNGS--KGPLSTVA 1734

Query: 566  TFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPA-----LPEAHALGTLSAQ 620
              P   +       A G      P+  ++ PE       + A     LP+  +    +A 
Sbjct: 1735 PAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAP 1794

Query: 621  QPP------PAAATTSSTSLPFSPDSPGLLPNFPAPP 651
             PP      P+   T      F P SPGL+   P+ P
Sbjct: 1795 SPPVSLPLAPSPVPTLPPKQQFLPSSPGLVLESPSKP 1831



 Score = 63.5 bits (153), Expect = 7e-10
 Identities = 106/405 (26%), Positives = 144/405 (35%), Gaps = 61/405 (15%)

Query: 283  SPEDLERGAAPVSAEAAAQGSI-FLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGG 341
            SP++     +  SA A+++G++ +LA +  P     S       +   ++G    + N  
Sbjct: 766  SPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSAGPDTPIGN-- 823

Query: 342  PVIINGLALGEASSL--GPLLLTGGGGAP-----PPQPSPQGASETKTSLVLDPQTGEVR 394
              + + ++  EAS L    L   G   +P     P  PSP+GA        L P+   V 
Sbjct: 824  --LSSPVSPVEASFLPENSLSFQGSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKG--VT 879

Query: 395  LEEAQSEAPETKGAQVAAPGPALGEEVLGP-LAQVVPGPPTAATFPLPPGPVPAVAAPQV 453
            L   ++  P          GPA       P L+     P  A   P P G +PA  +P+ 
Sbjct: 880  LPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKKARATPAPKG-IPASPSPKG 938

Query: 454  VPLSPP--PGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAA 511
             P  P   P  P G  P +P    P+  PT    T P   G       GP +P    A  
Sbjct: 939  APTPPAATPPSPKG-GPATPS---PKWAPTPPAATPPSPKG-------GPATPSPKGAPT 987

Query: 512  GPANVHLINSGVGVTALQLPSATAPGNFLLANPVS--GSPIVTGVAVQQGKIILTATFPT 569
             PA       G   T     + T P       P S  GSP  T     +G     A  P 
Sbjct: 988  PPAATPPSPKGGPATPSPKGAPTPPA----VTPPSPKGSPAAT--PFPKGASTPPAATPP 1041

Query: 570  SMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATT 629
            S   S    P P  A P  P   +  P+GG      PA P      +L     PPAA   
Sbjct: 1042 SPKGSPAATPLPKGA-PTTPAATLPSPKGG------PATP------SLKGAPTPPAATPP 1088

Query: 630  SSTSLPFSPD------SPGLLPNFP-----APPPEGLMLSPAAVP 663
            S    P +P        P   P  P      PP +G   +PAA P
Sbjct: 1089 SPKGGPATPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATP 1133



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 100/432 (23%), Positives = 146/432 (33%), Gaps = 63/432 (14%)

Query: 310  GPPAPCPASSSILVNGSFLA----ASGSPAVLL----NGGPVIINGLALGEASSLGPLLL 361
            G P P PA++   + G         + +PAV+      GGP            +  P   
Sbjct: 1262 GAPTP-PAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSP 1320

Query: 362  TGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEV 421
             G  G PPP+ +P   + T  S    P         +    P T  ++     PA     
Sbjct: 1321 KGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATT--PSSKGGPTTPSSKEGPTPPAATPSH 1378

Query: 422  LGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPT 481
             G  A   P P      P P G      +P V+PLSP        +P +P+       P+
Sbjct: 1379 KGGPAMTPPSPKRGPAIPSPKGDP---TSPAVIPLSPKK------APATPVTREGAATPS 1429

Query: 482  SQVVTLPQAVGPLQLLAA--------GPGSPVKVAAAAGPANVHLINSGVGVTALQLPSA 533
               +T P AV P+ L  A        GP +P        PA V   +        Q+ ++
Sbjct: 1430 KGDLT-PPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPA-VTPPSPKEPPAPKQVATS 1487

Query: 534  TAPGNFLLANPVSGSPIVTGVAVQQGKIILTATF-------PTSMLVSQVLPPAPGLALP 586
            ++P          G+P +  V     K +            PT+ L+S+  P        
Sbjct: 1488 SSPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPAT------ 1541

Query: 587  LKPETAISVPEGGLPVAP-SPALP---EAHALGTLSAQQPPPAAATTSSTSLPFSPDSPG 642
            L P+ A+  P   +P    +PA+P   EA A  +      PPA   ++    P SP    
Sbjct: 1542 LAPKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAP-SPKELL 1600

Query: 643  LLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPE 702
            + P   +P P+     PA  P                  EKG  T AP      P   P 
Sbjct: 1601 IPPAVTSPSPKEAPTPPAVTPP---------------SPEKGPATPAPKGTPTSPPVTPS 1645

Query: 703  GLLLGATAGGEV 714
             L    T+   V
Sbjct: 1646 SLKDSPTSPASV 1657



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 66/253 (26%), Positives = 98/253 (38%), Gaps = 45/253 (17%)

Query: 426 AQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGL--------SPTSPLLNLPQ 477
           A   P P T A+ PL   P P  ++   +PL   P  PT L        SP +  L  P 
Sbjct: 64  ASPFPSPSTIASTPLEV-PFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPM 122

Query: 478 VVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAA-----AAGPANVHLINSGVGVTALQLPS 532
           + PT +    P +  PL L+A  P S  K +A        P +V +  SG  +T      
Sbjct: 123 IAPTLKGT--PSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVIT------ 174

Query: 533 ATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETA 592
                   L+ P++ S   T +     +++       S       PP     +P    T 
Sbjct: 175 --------LSAPIAPSEPKTNLNKVPSEVVPNPKGTPS-------PPCIVSTVPYHCVTP 219

Query: 593 ISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLP-NFPAPP 651
           ++  + G+      +LP+     TL+   P     T SS  +  SP +PG L    P  P
Sbjct: 220 MASIQSGVA-----SLPQTTPTTTLAIASPQVKDTTISSVLI--SPQNPGSLSLKGPVSP 272

Query: 652 PEGLMLSPAAVPV 664
           P  L LS  ++PV
Sbjct: 273 PAALSLSTQSLPV 285



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 94/358 (26%), Positives = 121/358 (33%), Gaps = 49/358 (13%)

Query: 311  PPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPP 370
            PPA  P  +  +   S  +A    A      P   +G A   ASS G L           
Sbjct: 740  PPAGTPPGTKKVDGISHTSALAPVASSPKECPTEDSG-ASATASSKGTLTYLADS----- 793

Query: 371  QPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVP 430
             PSP G S       + PQT     ++  S  P+T    +++P   +    L   +    
Sbjct: 794  -PSPLGVS-------VSPQTKRPPTKKG-SAGPDTPIGNLSSPVSPVEASFLPENSLSFQ 844

Query: 431  GP---PTAATFPLPPGPVPAVAAPQVVPLSPPP-GYPTGLSPTSPLLNLPQVVPTSQVVT 486
            G    P     P PP P  A     V PLSP     P   +PT  ++NLP   P     T
Sbjct: 845  GSKDSPATTHSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLP--FPKEGPAT 902

Query: 487  LPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVS 546
                  P   L+    SP K  A   P  +    S  G  A   P+AT P       P +
Sbjct: 903  PAPKQAPA--LSMTSSSPKKARATPAPKGIPASPSPKG--APTPPAATPPSP--KGGPAT 956

Query: 547  GSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSP 606
             SP               A  P S       P   G   P  P      P+GG      P
Sbjct: 957  PSPKWAPTP--------PAATPPSPKGGPATPSPKGAPTP--PAATPPSPKGG------P 1000

Query: 607  ALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPV 664
            A P      T  A  PP    + ++T  P    +P   P    P P+G   SPAA P+
Sbjct: 1001 ATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTP---PAATPPSPKG---SPAATPL 1052



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 104/444 (23%), Positives = 140/444 (31%), Gaps = 69/444 (15%)

Query: 311 PPAPCPAS-----SSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGG 365
           PP P P       SS+LV         +    L G P   +    G  +   P +L    
Sbjct: 507 PPLPDPEDLKNLPSSVLVKFPTQKDLQTVPASLEGAP--FSPAQAGLTTKKDPTVLPLVQ 564

Query: 366 GAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQ------------SEAPETKGAQVAAP 413
            AP   PS Q  S +   + L P+    +    +            S       A V   
Sbjct: 565 AAPKNSPSFQSTSSSP-EIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKT 623

Query: 414 GPALGEEVLGPLAQVVPGPPTAATFPL----PPGPVPAVA---APQVVPLSP-------- 458
               G +  GPL +     PT A FPL    P G  P  A   +      SP        
Sbjct: 624 DSYAGPDSAGPLLKSSLITPTVAAFPLESADPAGVAPTTAKGTSTYTTTASPFLEGTVSL 683

Query: 459 -PPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQ-AVGPLQLLAAGPGSPVKVAA-----AA 511
            P  +P      + L  +P       V   PQ    PL  L   P  P  V +     A 
Sbjct: 684 APKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPAG 743

Query: 512 GPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSM 571
            P     ++ G+  T+   P A++P       P   S   +  A  +G +   A  P+ +
Sbjct: 744 TPPGTKKVD-GISHTSALAPVASSPKEC----PTEDSG-ASATASSKGTLTYLADSPSPL 797

Query: 572 LVSQVLP----------------PAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALG 615
            VS V P                P   L+ P+ P  A  +PE  L    S   P      
Sbjct: 798 GVS-VSPQTKRPPTKKGSAGPDTPIGNLSSPVSPVEASFLPENSLSFQGSKDSPAT---- 852

Query: 616 TLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGT 675
           T S   P P  A T S   P SP    L P     P    +  P   P   A  +  A +
Sbjct: 853 THSPTPPSPKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALS 912

Query: 676 EGLLEAEKGLGTQAPHTVLRLPDP 699
                 +K   T AP  +   P P
Sbjct: 913 MTSSSPKKARATPAPKGIPASPSP 936



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 77/317 (24%), Positives = 114/317 (35%), Gaps = 56/317 (17%)

Query: 348 LALGEASSLGPLLLTGGGGAPPP-QPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETK 406
           L +  A S+   L   G   PPP  P+PQ                +  L  A   +P   
Sbjct: 26  LPMSSALSVTAALGQPGPTLPPPCSPAPQ----------------QCPLSAANQASPFPS 69

Query: 407 GAQVAA-----PGPALGEEVLGPLAQVVPGP---PTAATFPLPPGPVPAVAAPQVVPLSP 458
            + +A+     P P        PL      P   P     P+ P  + A+A+P + P   
Sbjct: 70  PSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAAL-ALASPMIAPTLK 128

Query: 459 PPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHL 518
             G P+  +P + +   P  V  S          P  +  A  GS + ++A   P+    
Sbjct: 129 --GTPSSSAPLALVALAPHSVQKSSAFPPNLLTSPPSVAVAESGSVITLSAPIAPSEPKT 186

Query: 519 INSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLP 578
             + V    +  P  T P    + + V    +    ++Q G   L  T PT+ L      
Sbjct: 187 NLNKVPSEVVPNPKGT-PSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTL------ 239

Query: 579 PAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQP--PPAAATTSSTSLPF 636
               +A P   +T IS       V  SP  P     G+LS + P  PPAA + S+ SLP 
Sbjct: 240 ---AIASPQVKDTTIS------SVLISPQNP-----GSLSLKGPVSPPAALSLSTQSLPV 285

Query: 637 SPDS-----PGLLPNFP 648
              S     P   P+FP
Sbjct: 286 VTSSQKTAGPNTPPDFP 302



 Score = 40.4 bits (93), Expect = 0.006
 Identities = 95/401 (23%), Positives = 146/401 (36%), Gaps = 50/401 (12%)

Query: 283 SPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGP 342
           SP+  +   + V       GS+ L G   P   PA+ S+      +  S         GP
Sbjct: 243 SPQVKDTTISSVLISPQNPGSLSLKG---PVSPPAALSLSTQSLPVVTSSQKTA----GP 295

Query: 343 VIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEA 402
                  +   S L PL  +  G       S Q   +T  S + DP    + ++ + + A
Sbjct: 296 NTPPDFPISLGSHLAPLHQSSFG-------SVQLLGQTGPSALSDPTVKTISVDHSSTGA 348

Query: 403 PETKGAQVAAPGPALGEEVLGPLA-------QVVPGPPTAATFPLPPGPVPAVAAPQVVP 455
                  V  P P+  E V   +A        V  GP T ++    P     VA      
Sbjct: 349 SYPSQRSVIPPLPSRNEVVPATVAAFPVVAPSVDKGPSTISSITCSPSGSLNVATS--FS 406

Query: 456 LSPPPGYPTGLSPTSPLLNLPQV--VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGP 513
           LSP        SP +   + P V  +P S V T P  V     +AA P +  +VA    P
Sbjct: 407 LSPTTSLILKSSPNATY-HYPLVAQMPVSSVGTTPLVVTNPCTIAAAPTTTFEVATCVSP 465

Query: 514 ANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLV 573
                ++SG     +     T+P   ++A PV+     T VA    +I ++   P    +
Sbjct: 466 P----MSSG----PISNIEPTSPAALVMA-PVAPKEPSTQVATTL-RIPVSPPLPDPEDL 515

Query: 574 SQVLPPAPGLALPLKPETAISVPEG--GLPVAPSPA------LPEAHALGTLSAQQPPPA 625
              LP +  +  P + +   +VP    G P +P+ A       P    L   + +  P  
Sbjct: 516 KN-LPSSVLVKFPTQKDLQ-TVPASLEGAPFSPAQAGLTTKKDPTVLPLVQAAPKNSPSF 573

Query: 626 AATTSSTSLPFSPDS----PGLLPNFPAPPPEGLMLSPAAV 662
            +T+SS  +P SP++      L    P   P   M SP  V
Sbjct: 574 QSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGV 614



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 40/141 (28%), Positives = 59/141 (41%), Gaps = 25/141 (17%)

Query: 568 PTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAA 627
           P     + VLP +  L++      A+  P   LP   SPA P+   L   +   P P+ +
Sbjct: 17  PQPQAETAVLPMSSALSVT----AALGQPGPTLPPPCSPA-PQQCPLSAANQASPFPSPS 71

Query: 628 TTSSTSL--PF-------------SPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELS 672
           T +ST L  PF             +P++P  LPN   PP     +SPAA+ + S  +  +
Sbjct: 72  TIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPP-----ISPAALALASPMIAPT 126

Query: 673 AGTEGLLEAEKGLGTQAPHTV 693
                   A   L   APH+V
Sbjct: 127 LKGTPSSSAPLALVALAPHSV 147



 Score = 37.7 bits (86), Expect = 0.039
 Identities = 66/268 (24%), Positives = 93/268 (34%), Gaps = 34/268 (12%)

Query: 265  PCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAA---QGSIFL-AGTGPPA------- 313
            P      G PT+   +  S +D     A V+ +  A   Q S  L A  GP A       
Sbjct: 1628 PATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQASKGLPAKKGPTALKEVLVA 1687

Query: 314  PCPASSSILV----NGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLL-------- 361
            P P S+ I+      G     S + +  +   P   NG + G  S++ P  L        
Sbjct: 1688 PAPESTPIITAPTRKGPQTKKSSATSPPICPDPSAKNG-SKGPLSTVAPAPLLPVQKDSS 1746

Query: 362  --TGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSE----APETKGAQVAAPGP 415
                G  A      P    E+K S  L     E  L + +S     AP    +   AP P
Sbjct: 1747 KTAKGKDASHSPKGPLAPPESKASTPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSP 1806

Query: 416  ALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNL 475
                  L P  Q +P  P       P  P+      +++PL PP     G+   S L+N+
Sbjct: 1807 V---PTLPPKQQFLPSSP-GLVLESPSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNM 1862

Query: 476  PQVVPTSQVVTLPQAVGPLQLLAAGPGS 503
            P        V  P A  P+     G G+
Sbjct: 1863 PTPKSAGIPVPTPSAKQPVTKNNKGSGT 1890


>gi|32455273 WNK lysine deficient protein kinase 2 [Homo sapiens]
          Length = 2217

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 128/471 (27%), Positives = 176/471 (37%), Gaps = 111/471 (23%)

Query: 280  SSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPAS---SSILVNGSFLAASGSPAV 336
            +S S  D  +G+   S   ++Q S+ L      AP PA    S  +  G  L  S  P++
Sbjct: 611  ASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSPAQCVCSPPVSEGPVLPQS-LPSL 669

Query: 337  LLNGGPVIINGLALGE-----------------ASSLGPLLL-------TGGGG-APPPQ 371
                 P    GL +G                  A S  P+L        TG G  APP Q
Sbjct: 670  GAYQQPTAAPGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQ 729

Query: 372  PSPQGASETKTSLVLDPQTGEVRLEEAQSEAPE--TKGAQVAAPGPA----LGEEVLGPL 425
              P  A  T    VL PQ   V L+      P      +QV AP       + +  L PL
Sbjct: 730  QPPPLAQPTPLPQVLAPQP-VVPLQPVPPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPL 788

Query: 426  AQV-------------------------VPGPPTAATFPLPPGP-------VPAVAAP-- 451
            AQV                         +P  PTA   P+PP         +P++AAP  
Sbjct: 789  AQVPPQMPPIPVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLP 848

Query: 452  --------QVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQL---LAAG 500
                    Q V L  PPG P  +   + + N P  +P   V   P  V  L +   +A  
Sbjct: 849  PASPALPLQAVKLPHPPGAPLAMPCRTIVPNAPATIPLLAVA--PPGVAALSIHSAVAQL 906

Query: 501  PGSPV------KVAAAAGPANVHLINSGVGVTALQL---PSATAPGNFLLANP--VSGSP 549
            PG PV      ++A    P + H     +  T  Q    P  T P   +L     +   P
Sbjct: 907  PGQPVYPAAFPQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLPPQP 966

Query: 550  IVTGVAVQQGKIILTATFPTSMLVSQ-VLPPAPGLALPLKPETAIS-VPEGGLPVA-PSP 606
            ++     +  + +L    P  ML  Q VLPP P  ALP++PE     +PE   P A P  
Sbjct: 967  VLPPQPTRPPQPVLP---PQPMLPPQPVLPPQP--ALPVRPEPLQPHLPEQAAPAATPGS 1021

Query: 607  AL----PEAHALGTLSAQQP----PPAAATTSSTSLPFSPDSPGLLPNFPA 649
             +    P  +A+  ++AQ P    PPAA  +        P +P LLP FP+
Sbjct: 1022 QILLGHPAPYAVD-VAAQVPTVPVPPAAVLSPPLPEVLLPAAPELLPQFPS 1071



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 119/410 (29%), Positives = 155/410 (37%), Gaps = 96/410 (23%)

Query: 277 EDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSS--ILVNGSFLAASGSP 334
           E E   + + L     P SA + A  S F +G G      + SS   ++ GS   A+ SP
Sbjct: 588 EPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSVMLGSLADAAPSP 647

Query: 335 AVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQ-GASETKTSLVLDPQTGEV 393
           A  +   PV           S GP+L         PQ  P  GA +  T+          
Sbjct: 648 AQCVCSPPV-----------SEGPVL---------PQSLPSLGAYQQPTA---------- 677

Query: 394 RLEEAQSEAPETKGAQVAAPG--PALGEEVLGP---LAQVVPGP----PTAATFPLPPG- 443
                   AP      V AP   P+L +    P    A V+P P    PT    P PPG 
Sbjct: 678 --------APGLPVGSVPAPACPPSLQQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQ 729

Query: 444 ---------PVPAVAAPQ-VVPLSP-PPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVG 492
                    P+P V APQ VVPL P PP  P  L+P S +    Q+ P    + +PQA  
Sbjct: 730 QPPPLAQPTPLPQVLAPQPVVPLQPVPPHLPPYLAPASQVGAPAQLKP----LQMPQA-- 783

Query: 493 PLQLLAAGPGS--PVKVAAAAGP-ANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSP 549
           PLQ LA  P    P+ V     P A +     G+      LP+AT P    +  P   SP
Sbjct: 784 PLQPLAQVPPQMPPIPVVPPITPLAGI----DGLPPALPDLPTATVPP---VPPPQYFSP 836

Query: 550 IVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALP 609
            V         I+ +   P        LPPA   ALPL+       P   L +     +P
Sbjct: 837 AV---------ILPSLAAP--------LPPASP-ALPLQAVKLPHPPGAPLAMPCRTIVP 878

Query: 610 EAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSP 659
            A A   L A  PP  AA +  +++   P  P     FP   P  +  SP
Sbjct: 879 NAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAFPQMAPTDVPPSP 928



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 85/341 (24%), Positives = 112/341 (32%), Gaps = 64/341 (18%)

Query: 342  PVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASET----KTSLVLDPQTGEVRLEE 397
            PV+     L     L P L        PP P PQ  S        +  L P +  + L+ 
Sbjct: 799  PVVPPITPLAGIDGLPPALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQA 858

Query: 398  AQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP-------LPPGPVPAVAA 450
             +   P   GA +A P   +       +  +   PP  A          LP  PV   A 
Sbjct: 859  VK--LPHPPGAPLAMPCRTIVPNAPATIPLLAVAPPGVAALSIHSAVAQLPGQPVYPAAF 916

Query: 451  PQVVPLSPPPGY-----------------------PTGLSPTSPLLNLPQVVPTSQVVTL 487
            PQ+ P   PP                         P  + P  P L  PQ V   Q    
Sbjct: 917  PQMAPTDVPPSPHHTVQNMRATPPQPALPPQPTLPPQPVLPPQPTLP-PQPVLPPQPTRP 975

Query: 488  PQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSG 547
            PQ V P Q +   P  PV     A P     +   +   A   P+AT     LL +P   
Sbjct: 976  PQPVLPPQPML--PPQPVLPPQPALPVRPEPLQPHLPEQAA--PAATPGSQILLGHP--- 1028

Query: 548  SPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPA 607
            +P    VA Q    + T   P + ++S   PP P + LP  PE               P 
Sbjct: 1029 APYAVDVAAQ----VPTVPVPPAAVLS---PPLPEVLLPAAPELL-------------PQ 1068

Query: 608  LPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFP 648
             P + A  + S Q  P   AT    + P  P  PG+    P
Sbjct: 1069 FPSSLATVSASVQSVPTQTATLLPPANPPLPGGPGIASPCP 1109



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 78/331 (23%), Positives = 110/331 (33%), Gaps = 64/331 (19%)

Query: 405 TKGAQVAAPGPALGEE-------------------------------------------- 420
           T  AQ   PGP   EE                                            
Sbjct: 576 TYHAQAGQPGPPEPEEPEADQHLLPPTLPTSATSLASDSTFDSGQGSTVYSDSQSSQQSV 635

Query: 421 VLGPLAQVVPGP-PTAATFPLPPGPVPAVAAPQVVPLSPP---PGYPTGLSPTSPL-LNL 475
           +LG LA   P P     + P+  GPV   + P +     P   PG P G  P      +L
Sbjct: 636 MLGSLADAAPSPAQCVCSPPVSEGPVLPQSLPSLGAYQQPTAAPGLPVGSVPAPACPPSL 695

Query: 476 PQVVPTSQVVTLPQAVGPLQLLAAGPGSPV----KVAAAAGPANVHLINSGVGVTALQLP 531
            Q  P   +   P    P   +  GPG P     +    A P  +  + +   V  LQ  
Sbjct: 696 QQHFPDPAMSFAPVLPPPSTPMPTGPGQPAPPGQQPPPLAQPTPLPQVLAPQPVVPLQPV 755

Query: 532 SATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLA-LPLKPE 590
               P     A+ V     +  + + Q  +   A  P  M    V+PP   LA +   P 
Sbjct: 756 PPHLPPYLAPASQVGAPAQLKPLQMPQAPLQPLAQVPPQMPPIPVVPPITPLAGIDGLPP 815

Query: 591 TAISVPEGGLPVAPSPA-LPEAHALGTLSAQQPPPA-AATTSSTSLPFSPDSP------G 642
               +P   +P  P P     A  L +L+A  PP + A    +  LP  P +P       
Sbjct: 816 ALPDLPTATVPPVPPPQYFSPAVILPSLAAPLPPASPALPLQAVKLPHPPGAPLAMPCRT 875

Query: 643 LLPNFPAPPPEGLMLSP--AAVPVWSAGLEL 671
           ++PN PA  P   +  P  AA+ + SA  +L
Sbjct: 876 IVPNAPATIPLLAVAPPGVAALSIHSAVAQL 906



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 43/159 (27%), Positives = 53/159 (33%), Gaps = 22/159 (13%)

Query: 360  LLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALG- 418
            LL+  G + PP   P   + +   +   PQ G         E      +Q   PG   G 
Sbjct: 1367 LLSQAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQGL 1426

Query: 419  ---EEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVV----------PLSPPPGYPTG 465
                E   PLA+    P   A  PL  G  P   AP+            PL PP   P  
Sbjct: 1427 TSELETSQPLAETHEAP--LAVQPLVVGLAPCTPAPEAASTRDASAPREPLPPPAPEP-- 1482

Query: 466  LSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSP 504
                SP    PQ         LP AVG + L  +   SP
Sbjct: 1483 ----SPHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSP 1517



 Score = 38.5 bits (88), Expect = 0.023
 Identities = 50/203 (24%), Positives = 70/203 (34%), Gaps = 34/203 (16%)

Query: 452  QVVPLSPPPGYPTGLSPTSPLLN-LPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAA 510
            Q  P +PP   P  L+P+SP +  LPQ        T+P+        A GPG+P      
Sbjct: 1370 QAGPSNPPGAPPAPLAPSSPPVTALPQDGAAPATSTMPEPASGTASQAGGPGTPQ----- 1424

Query: 511  AGPANVHLINSGVGVTA-LQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPT 569
                         G+T+ L+     A  +     P++  P+V G+A         +T   
Sbjct: 1425 -------------GLTSELETSQPLAETH---EAPLAVQPLVVGLAPCTPAPEAASTRDA 1468

Query: 570  SMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATT 629
            S     + PPAP  +    P +    P  G P    PA   A +L T     PP      
Sbjct: 1469 SAPREPLPPPAPEPS----PHSGTPQPALGQPAPLLPAAVGAVSLATSQLPSPPLGPTVP 1524

Query: 630  SSTSLPFSPDSPGLLPNFPAPPP 652
                     D  G       PPP
Sbjct: 1525 PQPPSALESDGEG-------PPP 1540



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 43/143 (30%), Positives = 51/143 (35%), Gaps = 13/143 (9%)

Query: 529  QLPSATAPGNFLLANPVS---GSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLAL 585
            QL S   P N   A P      SP VT +  Q G    T+T P     +      PG   
Sbjct: 1366 QLLSQAGPSNPPGAPPAPLAPSSPPVTALP-QDGAAPATSTMPEPASGTASQAGGPGTPQ 1424

Query: 586  PLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLP---FSPDSPG 642
             L  E   S P      AP    P    L   +   P P AA+T   S P     P +P 
Sbjct: 1425 GLTSELETSQPLAETHEAPLAVQPLVVGLAPCT---PAPEAASTRDASAPREPLPPPAPE 1481

Query: 643  LLPNFPAPPP---EGLMLSPAAV 662
              P+   P P   +   L PAAV
Sbjct: 1482 PSPHSGTPQPALGQPAPLLPAAV 1504



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 37/135 (27%), Positives = 51/135 (37%), Gaps = 30/135 (22%)

Query: 369  PPQPS--PQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426
            PPQP   PQ     + +L + P+  +  L E Q+    T G+Q+    PA     +    
Sbjct: 981  PPQPMLPPQPVLPPQPALPVRPEPLQPHLPE-QAAPAATPGSQILLGHPAPYAVDVAAQV 1039

Query: 427  QVVPGPPTAATFP------LPPGP-------------------VPAVAAPQVVPLSPP-P 460
              VP PP A   P      LP  P                   VP   A  + P +PP P
Sbjct: 1040 PTVPVPPAAVLSPPLPEVLLPAAPELLPQFPSSLATVSASVQSVPTQTATLLPPANPPLP 1099

Query: 461  GYPTGLSPTSPLLNL 475
            G P G++   P + L
Sbjct: 1100 GGP-GIASPCPTVQL 1113



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 17/49 (34%), Positives = 21/49 (42%)

Query: 48  AAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCE 96
           A    G  AA A A     PG PG+P +A  EP       P+ +A   E
Sbjct: 86  AERARGRPAAPAPAALVAQPGAPGAPADAGPEPVGTQEPGPDPIAAAVE 134


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 95/371 (25%), Positives = 127/371 (34%), Gaps = 37/371 (9%)

Query: 331 SGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQT 390
           SGSPA     GP      A G A    P      GG  P +P P             P  
Sbjct: 64  SGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPA 123

Query: 391 GEVRLE---EAQSEAPETKGAQVAA-PGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVP 446
            ++R      A S AP    A VAA P PA       P     P  P A      PGP P
Sbjct: 124 AKLRPPPEGSAGSCAPVPAAAAVAAGPEPA-------PAGPAKPAGPAALAARAGPGPGP 176

Query: 447 AVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVK 506
               P   P  P PG P G      L     ++ +        A   + L+  GP + + 
Sbjct: 177 ---GPGPGP-GPGPGKPAGPGAAQTLNGSAALLNSHHA-----AAPAVSLVNNGPAALLP 227

Query: 507 VAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTAT 566
           +   A P  V      VG  A   P+A +P       P + +P     A           
Sbjct: 228 LPKPAAPGTVIQTPPFVGAAAPPAPAAPSP-------PAAPAPAAPAAAPPP-----PPP 275

Query: 567 FPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAA 626
            P ++      P  P  A P  P  A +   G    AP+PA P A     +S Q  P AA
Sbjct: 276 APATLARPPGHPAGPPTAAPAVPPPAAAQNGGSAGAAPAPA-PAAGGPAGVSGQPGPGAA 334

Query: 627 ATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLG 686
           A   +  +    +SP  +    A PP    L+ +     +A + +    +G L +   + 
Sbjct: 335 AAAPAPGV--KAESPKRV--VQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVP 390

Query: 687 TQAPHTVLRLP 697
             AP T   LP
Sbjct: 391 PPAPGTPTGLP 401



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 103/424 (24%), Positives = 139/424 (32%), Gaps = 70/424 (16%)

Query: 259 GAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVS-AEAAAQGSIFLAGTGPPA---- 313
           GA G  P  + ++G P    E   +      G  P      + +  +  AG  PPA    
Sbjct: 69  GAAGAGPA-APAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLR 127

Query: 314 PCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLT-------GGGG 366
           P P  S+    GS      + AV     P        G A   GP  L        G G 
Sbjct: 128 PPPEGSA----GSCAPVPAAAAVAAGPEPA-----PAGPAKPAGPAALAARAGPGPGPGP 178

Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAA----PGPALGEEVL 422
            P P P P   +    +  L+     +    A + A        AA    P PA    V+
Sbjct: 179 GPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVI 238

Query: 423 ---------GPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLL 473
                     P A   P PP AA  P  P   P    P    L+ PPG+P G    +P +
Sbjct: 239 QTPPFVGAAAPPAPAAPSPP-AAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAV 297

Query: 474 NLPQVVPTSQVVTLPQAVGPLQLLAAGP----GSPVKVAAAAGPANVHLINSGVGVTALQ 529
             P             A  P    A GP    G P   AAAA PA       GV   + +
Sbjct: 298 PPPAAAQNGGSAGAAPAPAP---AAGGPAGVSGQPGPGAAAAAPA------PGVKAESPK 348

Query: 530 LPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKP 589
                AP       P + +   +G A     +++  T   ++       P+P    P  P
Sbjct: 349 RVVQAAP-------PAAQTLAASGPASTAASMVIGPTMQGAL-------PSPAAVPPPAP 394

Query: 590 ETAISVPEG--GLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNF 647
            T   +P+G  G         P A   G  +   P     T  +  LP  P +P  + NF
Sbjct: 395 GTPTGLPKGAAGAVTQSLSRTPTATTSGIRATLTP-----TVLAPRLPQPPQNPTNIQNF 449

Query: 648 PAPP 651
             PP
Sbjct: 450 QLPP 453



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 103/424 (24%), Positives = 149/424 (35%), Gaps = 53/424 (12%)

Query: 257 RTGAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP----P 312
           R G G G P      G    +     + + L   AA +++  AA  ++ L   GP    P
Sbjct: 169 RAGPGPG-PGPGPGPGPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLP 227

Query: 313 APCPAS-SSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGP-----LLLTGGGG 366
            P PA+  +++    F+ A+  PA      P      A   A    P     L    G  
Sbjct: 228 LPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHP 287

Query: 367 APPPQPSPQ----GASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVL 422
           A PP  +P      A++   S    P         A        GA  AAP P +  E  
Sbjct: 288 AGPPTAAPAVPPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESP 347

Query: 423 GPLAQVVP---------GPP-TAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGL------ 466
             + Q  P         GP  TAA+  + P    A+ +P  VP  P PG PTGL      
Sbjct: 348 KRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVP-PPAPGTPTGLPKGAAG 406

Query: 467 SPTSPLLNLPQVVPTSQVVTL-PQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVG- 524
           + T  L   P    +    TL P  + P   L   P +P  +     P  + L+ S  G 
Sbjct: 407 AVTQSLSRTPTATTSGIRATLTPTVLAPR--LPQPPQNPTNIQNFQLPPGMVLVRSENGQ 464

Query: 525 --------VTALQLPSATAPGNFLL---ANPVSGSPIVTGVAVQQGKIILTATFPTSMLV 573
                   +  +Q  +   P   +    A P S  P+        G  I+      + ++
Sbjct: 465 LLMIPQQALAQMQAQAHAQPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTII 524

Query: 574 SQVLPPA----PGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATT 629
            QV        P   L   P     +  GG   A + +L  A A+ T + Q+  P A TT
Sbjct: 525 KQVSQAQTTVQPSATLQRSPGVQPQLVLGG--AAQTASLGTATAVQTGTPQRTVPGATTT 582

Query: 630 SSTS 633
           SS +
Sbjct: 583 SSAA 586



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 80/283 (28%), Positives = 100/283 (35%), Gaps = 67/283 (23%)

Query: 402 APETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPG 461
           AP T   + AA G ALG  V       V G P  A    P  P  A  AP   P  PP G
Sbjct: 44  APRTPEVRAAAAG-ALGNHV-------VSGSPAGAAGAGPAAP--AEGAPGAAPEPPPAG 93

Query: 462 Y----------PTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAA- 510
                      P   SP  PL+      P +++   P+        +AG  +PV  AAA 
Sbjct: 94  RARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKLRPPPEG-------SAGSCAPVPAAAAV 146

Query: 511 --------AGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKII 562
                   AGPA      +G    A +      PG      P  G P   G A       
Sbjct: 147 AAGPEPAPAGPAKP----AGPAALAARAGPGPGPGPGPGPGPGPGKPAGPGAA------- 195

Query: 563 LTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQP 622
                  ++  S  L  +   A P     A+S+   G P A  P LP+  A GT+    P
Sbjct: 196 ------QTLNGSAALLNSHHAAAP-----AVSLVNNG-PAALLP-LPKPAAPGTVIQTPP 242

Query: 623 ------PPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSP 659
                 PPA A  S  + P +P +P   P  P P P  L   P
Sbjct: 243 FVGAAAPPAPAAPSPPAAP-APAAPAAAPPPPPPAPATLARPP 284



 Score = 35.4 bits (80), Expect = 0.19
 Identities = 32/103 (31%), Positives = 37/103 (35%), Gaps = 5/103 (4%)

Query: 5   PAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGAEGP 64
           P E SAG  A   A AA AA  E             A     AA AG G G       GP
Sbjct: 129 PPEGSAGSCAPVPAAAAVAAGPEPAPAG----PAKPAGPAALAARAGPGPGPGPGPGPGP 184

Query: 65  GSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRL 107
           G PG P  P  A +   +    +    A    +L+  G A  L
Sbjct: 185 G-PGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALL 226



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 41/136 (30%), Positives = 49/136 (36%), Gaps = 25/136 (18%)

Query: 2   ATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTLQAAEGEAAAAAGAGAGAAAAGA 61
           A  PA P+A P     A A  A                 A    AAA  G  AGAA A A
Sbjct: 260 APAPAAPAAAPPPPPPAPATLARPPGHPAGPPT---AAPAVPPPAAAQNGGSAGAAPAPA 316

Query: 62  EGPGSP----GVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPA 117
              G P    G PG    AA+  P     SP++V       +QA           A P A
Sbjct: 317 PAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRV-------VQA-----------APPAA 358

Query: 118 ERLRGSDPVLRARALV 133
           + L  S P   A ++V
Sbjct: 359 QTLAASGPASTAASMV 374



 Score = 32.0 bits (71), Expect = 2.1
 Identities = 35/117 (29%), Positives = 45/117 (38%), Gaps = 7/117 (5%)

Query: 22  AAATEEEEEEARQLLQTLQAAEGEAA--AAAGAGAGAAAAGAEGP--GSPGVPGSPPEAA 77
           AA+       A +  +   AA G       +G+ AGAA AG   P  G+PG    PP A 
Sbjct: 34  AASAAHHHHLAPRTPEVRAAAAGALGNHVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAG 93

Query: 78  SEPPTGLRFSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVA 134
              P G              L+ AG A   ++     PP E   GS   + A A VA
Sbjct: 94  RARPGGGGPQRPGPPSPRRPLVPAGPAPPAAKL---RPPPEGSAGSCAPVPAAAAVA 147


>gi|160707881 formin 2 [Homo sapiens]
          Length = 1722

 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 102/377 (27%), Positives = 131/377 (34%), Gaps = 68/377 (18%)

Query: 358  PLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPAL 417
            PL    G G PPP P P  A      L   P  G + L       P   GA +  P P  
Sbjct: 933  PLPPLPGAGIPPPPPLPGAAIPPPPPL---PGAG-IPL------PPPLPGAGIPPPPPLP 982

Query: 418  GEEVLGPL----AQVVPGPPTAATFPLPPGPVPAVAAPQVVPL-----SPPPGYP-TGLS 467
            G  +  P     A + P PP       PP P+P    P   PL      PPP  P  G+ 
Sbjct: 983  GAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP 1042

Query: 468  PTSPL----LNLPQVVPTSQVVTLPQAVG-----PLQLLAAGPGSPVKVAAAAGPANVHL 518
            P  PL    +  P  +P + +   P   G     P  L  AG   P  +  A  P    L
Sbjct: 1043 PPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPL 1102

Query: 519  INSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQV-- 576
               GVG+     P    PG       +   P + G  +     +  A  P    + +V  
Sbjct: 1103 --PGVGIP----PPPPLPG-----AGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGI 1151

Query: 577  --LPPAPGLALPLKPETAISVPEGGL---PVAPSPALPEAHALGTLSAQQPPPAAATTSS 631
               PP PG  +P  P     +P  G+   P  P   +P    L  +    PPP       
Sbjct: 1152 PPPPPLPGAGIPPPP----PLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPP----LPG 1203

Query: 632  TSLPFSPDSPGL-LPNFPAP--PPEGLML-SPAAVPVWSAGLELSAGTEGLLEAEKGLGT 687
              +P  P  PG+ +P  PAP  PP G  +  P  +PV    L    G+  L         
Sbjct: 1204 AGIPPPPPLPGMGIPPAPAPPLPPPGTGIPPPPLLPVSGPPLLPQVGSSTL--------- 1254

Query: 688  QAPHTVLRLPDPDPEGL 704
              P     LP P P GL
Sbjct: 1255 PTPQVCGFLPPPLPSGL 1271



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 96/369 (26%), Positives = 124/369 (33%), Gaps = 53/369 (14%)

Query: 306  LAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGG 365
            L G G P P P   + +     L  +G P      G  I     L  A    P  L G G
Sbjct: 937  LPGAGIPPPPPLPGAAIPPPPPLPGAGIPLPPPLPGAGIPPPPPLPGAGIPPPPPLPGAG 996

Query: 366  GAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPL 425
              PPP P P         L   P  G           P   GA +  P P  G  +  P 
Sbjct: 997  -IPPPPPLPGAGIPPPPPL---PGAGI-------PPPPPLPGAGIPPPPPLPGAGIPPPP 1045

Query: 426  ----AQVVPGPPTAATFPLPPGPVPAVAAPQVVPLS-----PPPGYP-TGLSPTSPLLNL 475
                A + P PP       PP P+P    P   PL      PPP  P  G+ P  PL  +
Sbjct: 1046 PLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGV 1105

Query: 476  ----PQVVPTSQVVTLPQAVG-----PLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVT 526
                P  +P + +   P   G     P  L  AG   P  +     P    L  +G+   
Sbjct: 1106 GIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPRVGIPPPPPLPGAGIPPP 1165

Query: 527  ALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALP 586
                 +   P   L    +   P + GV +     +  A  P         PP PG+ +P
Sbjct: 1166 PPLPGAGIPPPPPLPGVGIPPPPPLPGVGIPPPPPLPGAGIPPP-------PPLPGMGIP 1218

Query: 587  LKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPN 646
              P   +  P  G+P  P P LP +           PP      S++LP +P   G L  
Sbjct: 1219 PAPAPPLPPPGTGIP--PPPLLPVS----------GPPLLPQVGSSTLP-TPQVCGFL-- 1263

Query: 647  FPAPPPEGL 655
             P P P GL
Sbjct: 1264 -PPPLPSGL 1271



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 85/350 (24%), Positives = 117/350 (33%), Gaps = 65/350 (18%)

Query: 367  APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426
            +PPP P  + +S      ++ P    +         P      +  P P  G E+L P  
Sbjct: 857  SPPPLPCTESSSSMPGLGMVPPPPPPL----PGMTVPTLPSTAIPQPPPLQGTEMLPP-- 910

Query: 427  QVVPGPPTAATFPLPPGPVPAVAAPQVVPLS-----PPPGYP-TGLSPTSPL----LNLP 476
               P PP       PP P+P      + PL      PPP  P   + P  PL    + LP
Sbjct: 911  ---PPPPLPGAGIPPPPPLPGAGILPLPPLPGAGIPPPPPLPGAAIPPPPPLPGAGIPLP 967

Query: 477  QVVPTSQVVTLPQAVG-----PLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLP 531
              +P + +   P   G     P  L  AG   P  +  A  P    L  +G+       P
Sbjct: 968  PPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIPPPPPLPGAGIP------P 1021

Query: 532  SATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPET 591
                PG       +   P + G  +     +  A  P         PP PG  +P  P  
Sbjct: 1022 PPPLPG-----AGIPPPPPLPGAGIPPPPPLPGAGIPPP-------PPLPGAGIPPPP-- 1067

Query: 592  AISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPP 651
               +P  G+P  P P LP A          PPP         +P  P  PG+    P PP
Sbjct: 1068 --PLPGAGIP--PPPPLPGA------GIPPPPP----LPGAGIPPPPPLPGV--GIPPPP 1111

Query: 652  PEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDP 701
            P      P   P+  AG+       G      G+    P   + +P P P
Sbjct: 1112 PLPGAGIPPPPPLPGAGIPPPPPLPG-----AGIPPPPPLPRVGIPPPPP 1156



 Score = 33.9 bits (76), Expect = 0.56
 Identities = 64/252 (25%), Positives = 89/252 (35%), Gaps = 37/252 (14%)

Query: 485 VTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANP 544
           VT P   GP +    G      V  AAG  +    +SG         SAT   + L  + 
Sbjct: 141 VTGPGGPGPAEARVGGRPIAEDVETAAGAQDGQRTSSGSDTDIYSFHSATEQEDLL--SD 198

Query: 545 VSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISV------PEG 598
           +  +  +     QQ ++ L        L     P AP  A+  +P   + +      P G
Sbjct: 199 IQQAIRLQQQQQQQLQLQLQQQQQQQQLQGAEEPAAPPTAVSPQPGAFLGLDRFLLGPSG 258

Query: 599 GLPVAP-SP----------ALPEAHALGTLSAQQPPP------AAATTSSTSLPFSPDSP 641
           G   AP SP           LPE+ A      QQPP       + A +   + P + DSP
Sbjct: 259 GAGEAPGSPDTEQALSALSDLPESLAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSP 318

Query: 642 GLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLE-AEKG---------LGTQAPH 691
                FP  P  G     A  PV  AG     G E   E A +G         +G  AP 
Sbjct: 319 SSTA-FPF-PEAGPGEEAAGAPVRGAGDTDEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQ 376

Query: 692 TVLRLPDPDPEG 703
            +   P+ + +G
Sbjct: 377 RLGEEPEEEAQG 388



 Score = 32.7 bits (73), Expect = 1.2
 Identities = 33/105 (31%), Positives = 45/105 (42%), Gaps = 14/105 (13%)

Query: 1   MATLPAEPSAGPAAGGEAVAAAAATEEEEEEARQLLQTL-----QAAEGEAAAAA---GA 52
           +A  P EP   P+ GG  V+ A +    +  A+    +      +A  GE AA A   GA
Sbjct: 283 LAAEPREPQQPPSPGGLPVSEAPSLPAAQPAAKDSPSSTAFPFPEAGPGEEAAGAPVRGA 342

Query: 53  G----AGAAAAGAEGP-GSPGVPGSPPEAASEPPTGLRFSPEQVA 92
           G     G   A  + P GSPG   + PE   + P  L   PE+ A
Sbjct: 343 GDTDEEGEEDAFEDAPRGSPGEEWA-PEVGEDAPQRLGEEPEEEA 386



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 66/269 (24%), Positives = 96/269 (35%), Gaps = 52/269 (19%)

Query: 259 GAGGGAPCKSESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP--CP 316
           G  GGA    E+ G+P TE   S +  DL    A    E             PP+P   P
Sbjct: 255 GPSGGA---GEAPGSPDTEQALS-ALSDLPESLAAEPREPQQ----------PPSPGGLP 300

Query: 317 ASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQG 376
            S +  +  +  AA  SP+                  S+  P    G G      P  +G
Sbjct: 301 VSEAPSLPAAQPAAKDSPS------------------STAFPFPEAGPGEEAAGAPV-RG 341

Query: 377 ASETKTSLVLDPQTGEVRLEEAQSEAPETKGA-QVAAPGPA-LGEEVLGPLAQVVPGPPT 434
           A +T      D +  E   E+A   +P  + A +V    P  LGEE      +   GP  
Sbjct: 342 AGDT------DEEGEEDAFEDAPRGSPGEEWAPEVGEDAPQRLGEEP----EEEAQGPDA 391

Query: 435 AATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPL 494
            A   LP  P P+    +  PL      P  +  T+  L+ P   P+      P+ +   
Sbjct: 392 PAAASLPGSPAPSQRCFKPYPLIT----PCYIKTTTRQLSSPNHSPSQSPNQSPR-IKRR 446

Query: 495 QLLAAGPGSPVKVAAAAGPANVHLINSGV 523
              +   GS   +A+ A PA  H  + G+
Sbjct: 447 PEPSLSRGSRTALASVAAPAKKHRADGGL 475


>gi|46852161 methyl-CpG binding domain protein 6 [Homo sapiens]
          Length = 1003

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 116/429 (27%), Positives = 143/429 (33%), Gaps = 93/429 (21%)

Query: 263 GAPCKSESDGNPTTEDESSRSP-EDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSI 321
           GAP    +   P       +SP E L  GA P        G     G   P P P     
Sbjct: 474 GAPAPPAASKAPVVPSPVLQSPSEGLGMGAGPACPLPPLAG-----GEAFPFPSPEQGLA 528

Query: 322 LVNGSFLAASGS-PAVLLNGGPV---IINGLALGEASSLGPLLLTGGGGAPPPQPSPQGA 377
           L    F    G+ P  L  G P    ++N    G        +LTGGGG PPP+P     
Sbjct: 529 LSGAGFPGMLGALPLPLSLGQPPPSPLLNHSLFG--------VLTGGGGQPPPEP----- 575

Query: 378 SETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVP-GPPTAA 436
                  +L P  G                     PGP        PLA   P GP    
Sbjct: 576 -------LLPPPGG---------------------PGP--------PLAPGEPEGPSLLV 599

Query: 437 TFPLPPGPVPAVAAPQVVPLSPPPGYPTG--LSPTSPLLNLPQVVPTSQVVTLPQAVGPL 494
              LPP P           L PPP  P    L+   PLL L       +  +   A GP 
Sbjct: 600 ASLLPPPP---------SDLLPPPSAPPSNLLASFLPLLALGPTAGDGE-GSAEGAGGPS 649

Query: 495 QLLAAGPG--SPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPI-- 550
               +G G  SP+     + P  +  +NS +    L  PS T P   +L+ P  G P   
Sbjct: 650 GEPFSGLGDLSPLLFPPLSAPPTLIALNSALLAATLDPPSGTPPQPCVLSAPQPGPPTSS 709

Query: 551 VTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSP---- 606
           VT      G   L      S    Q+L P  G +L L   ++++   G LP    P    
Sbjct: 710 VTTATTDPGASSLGKAPSNSGRPPQLLSPLLGASL-LGDLSSLTSSPGALPSLLQPPGPL 768

Query: 607 --------ALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPA----PPPEG 654
                    LP   A   LS    P A    S    P  P++P L P  PA    P P  
Sbjct: 769 LSGQLGLQLLPGGGAPPPLSEASSPLACLLQSLQIPPEQPEAPCLPPESPASALEPEPAR 828

Query: 655 LMLSPAAVP 663
             LS  A P
Sbjct: 829 PPLSALAPP 837



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 128/501 (25%), Positives = 171/501 (34%), Gaps = 142/501 (28%)

Query: 265 PCKSESDG--NPTTEDESSRSPEDLERGAAPV-------SAEAAAQGSIFLAGTGPPAPC 315
           P  S SDG  N    D     P  L  G+ P        S      GS+     G PAP 
Sbjct: 421 PGPSHSDGSFNLLGSDAHLPPPPTLSSGSPPQPRHPIQPSLPGTTSGSLSSV-PGAPAPP 479

Query: 316 PASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSP- 374
            AS + +V    L    SP+  L        G+  G A  L PL     GG   P PSP 
Sbjct: 480 AASKAPVVPSPVLQ---SPSEGL--------GMGAGPACPLPPL----AGGEAFPFPSPE 524

Query: 375 QGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPT 434
           QG + +          G + L  +  + P         P P L   + G L      PP 
Sbjct: 525 QGLALSGAGF--PGMLGALPLPLSLGQPP---------PSPLLNHSLFGVLTGGGGQPPP 573

Query: 435 AATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLS---------PTSPLLNLPQVVPTSQVV 485
               P P GP P +A          PG P G S         P S LL  P   P++ + 
Sbjct: 574 EPLLPPPGGPGPPLA----------PGEPEGPSLLVASLLPPPPSDLLPPPSAPPSNLLA 623

Query: 486 TLPQAVGPLQLLAAGPGS---PVKVAAAAGPANVHLINSGVG-VTALQLPSATAPGNFLL 541
           +       L LLA GP +         A GP+      SG+G ++ L  P  +AP   + 
Sbjct: 624 SF------LPLLALGPTAGDGEGSAEGAGGPSGEPF--SGLGDLSPLLFPPLSAPPTLIA 675

Query: 542 ANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLP 601
            N                          S L++  L P  G                   
Sbjct: 676 LN--------------------------SALLAATLDPPSG------------------- 690

Query: 602 VAPSPALPEAHALGTLSAQQP-PPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPA 660
             P P +        LSA QP PP ++ T++T+ P    S G  P+    PP+  +LSP 
Sbjct: 691 TPPQPCV--------LSAPQPGPPTSSVTTATTDP-GASSLGKAPSNSGRPPQ--LLSPL 739

Query: 661 AVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPDPDPEG-----LLLGATAGGEVD 715
                  G  L      L  +   L      ++L+ P P   G     LL G  A   + 
Sbjct: 740 ------LGASLLGDLSSLTSSPGAL-----PSLLQPPGPLLSGQLGLQLLPGGGAPPPLS 788

Query: 716 EGLEAEAKVLTQLQSVPVEEP 736
           E     A +L  LQ +P E+P
Sbjct: 789 EASSPLACLLQSLQ-IPPEQP 808



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 96/411 (23%), Positives = 137/411 (33%), Gaps = 55/411 (13%)

Query: 272 GNPTTEDESSRSPED--LERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLA 329
           G+P     SS  P D  L   +  ++       +   A  GP +  P SS+ +     L 
Sbjct: 243 GSPPAPHASSSPPSDPPLFHCSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLG 302

Query: 330 A-SGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDP 388
              G+P V   G P  +    L  A+             P P PS       +       
Sbjct: 303 PLGGAPTVEGPGAPPFLASSLLSAAAK--------AQHPPLPPPSTLQGRRPRAQAPSAS 354

Query: 389 QTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPV-PA 447
            +  +R  + +   P T    +   GP             VP P    + P P  P+ P+
Sbjct: 355 HSSSLRPSQRRPRRPPTVFRLLEGRGPQTPRRSRPRAPAPVPQP---FSLPEPSQPILPS 411

Query: 448 VAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQ---------LLA 498
           V +   +P   P       +      +LP   PT    + PQ   P+Q          L+
Sbjct: 412 VLSLLGLPTPGPSHSDGSFNLLGSDAHLPPP-PTLSSGSPPQPRHPIQPSLPGTTSGSLS 470

Query: 499 AGPGSPVKVAAAAGPANVHLINSGVGVTALQLPS---ATAPGNFLLANPVSGSPIVTGVA 555
           + PG+P   AA+  P         V    LQ PS       G      P++G       +
Sbjct: 471 SVPGAPAPPAASKAPV--------VPSPVLQSPSEGLGMGAGPACPLPPLAGGEAFPFPS 522

Query: 556 VQQGKIILTATFPTSMLVSQVLPPAPGLALP---LKPETAISVPEGGLPVAPSPALPEAH 612
            +QG  +  A FP  ML +  LP + G   P   L       +  GG    P P LP   
Sbjct: 523 PEQGLALSGAGFP-GMLGALPLPLSLGQPPPSPLLNHSLFGVLTGGGGQPPPEPLLPPPG 581

Query: 613 ALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVP 663
             G       PP A        P  P+ P LL     PPP   +L P + P
Sbjct: 582 GPG-------PPLA--------PGEPEGPSLLVASLLPPPPSDLLPPPSAP 617



 Score = 35.0 bits (79), Expect = 0.25
 Identities = 63/234 (26%), Positives = 78/234 (33%), Gaps = 31/234 (13%)

Query: 428 VVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLP-QVVPTSQVVT 486
           V PGPP+A     PP  VP        P S PP  P  +S   P L  P  + P      
Sbjct: 138 VSPGPPSAR----PPCRVPPTTPLNGGPGSLPP-EPPSVSQAFPTLAGPGGLFPPRLADP 192

Query: 487 LPQ--AVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPS--ATAPGNFLLA 542
           +P   +  P  L      SP      A   N    N G  + +  +PS   + P     +
Sbjct: 193 VPSGGSSSPRFLPRGNAPSPAPPPPPAISLNAPSYNWGAALRSSLVPSDLGSPPAPHASS 252

Query: 543 NPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLAL--PLKPET----AISVP 596
           +P S  P+              A  P  +  S  LP  PG A   P+   T     +  P
Sbjct: 253 SPPSDPPLFH---------CSDALTPPPLPPSNNLPAHPGPASQPPVSSATMHLPLVLGP 303

Query: 597 EGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAP 650
            GG P    P  P   A   LS      AAA      LP      G  P   AP
Sbjct: 304 LGGAPTVEGPGAPPFLASSLLS------AAAKAQHPPLPPPSTLQGRRPRAQAP 351


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 99/387 (25%), Positives = 128/387 (33%), Gaps = 51/387 (13%)

Query: 367 APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGP----------- 415
           A P QP P+G    +   V  P+          S +P    +  A P P           
Sbjct: 258 AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSPSAPPSLQTLPS 317

Query: 416 -----------ALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPT 464
                      +LG   L      +P PP +     PP   PA+A P   PL  PP  P 
Sbjct: 318 PPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALP---PLQAPPS-PP 373

Query: 465 GLSPTSPLLNLPQVVPTSQVVTLPQA------VGPLQLLAAGPGSPVKVAAAAGPANVHL 518
              P SPL       P +  V L QA        P+Q   + P SP    +A  P+    
Sbjct: 374 ASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPP 433

Query: 519 INSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLP 578
             +   +     P A+ P +     P    P +    +Q  K    A    +    Q LP
Sbjct: 434 SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALP 493

Query: 579 PAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQ--QPPPAAATTSSTSLPF 636
             P       P  A   P   LP++P  A P   A   L+A   Q PP+   + +   P 
Sbjct: 494 SPPASF----PGQAPFSPSASLPMSPL-ATPPPQAPPVLAAPLLQVPPSPPASPTLQAPR 548

Query: 637 SPDSPGLLPNFPAPPPE---GLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTV 693
            P +PG  P+     P     L   P   P  S    LS      L       T  P   
Sbjct: 549 RPPTPG--PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGPD---LAGHSSSATSTPEE- 602

Query: 694 LRLPDPDPEGLLLGATAGGEVDEGLEA 720
           LR  D  PEG   GA A    D  L A
Sbjct: 603 LRGYDSGPEG---GAAASPPPDAELAA 626



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 82/322 (25%), Positives = 120/322 (37%), Gaps = 45/322 (13%)

Query: 370 PQPSPQGASETKTSLVLDPQTGEVRLEEAQS--EAPETKGAQVAAPGPALGEEVLGPLAQ 427
           P+ S   ASE  T+   +P     R   A    + P ++    +A  P       GP A+
Sbjct: 196 PRKSVSSASEHSTT---EPSPAARRRPSAGGGLQRPASRSLSSSAT-PLSSPARSGPSAR 251

Query: 428 VVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTL 487
             P  P   + P P G + A+  PQV P         G     PL + P   P+      
Sbjct: 252 GTPRAPAHPSQPKPKG-LQALRPPQVTPPRKDAAPALG-----PLSSSPLATPSPSAPPS 305

Query: 488 PQAVGPLQLLAAGPGSPVKVAAAA-GPANVHLINSGV--------------GVTALQLPS 532
           P A   LQ L + P +P   A  + G   +   +S +                 AL LP 
Sbjct: 306 PSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 365

Query: 533 ATAPGNFLLANPVSGSPIVTGVAVQQGKI---ILTATF---PTSMLVSQVLPPA-----P 581
             AP +   + P+S  P+ T        +   +L A F   P+  + +   PPA     P
Sbjct: 366 LQAPPSPPASPPLS--PLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSP 423

Query: 582 GLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSP 641
               P +   +++ P   +P +P PA P      T   Q PPP AA     + P  P +P
Sbjct: 424 SATPPSQAPPSLAAPPLQVPPSP-PASPPMSPSATPPPQAPPPLAAPPLQLAKP-PPQAP 481

Query: 642 GLLPNFPAPPPEGLMLSPAAVP 663
              P    PP + L   PA+ P
Sbjct: 482 ---PALATPPLQALPSPPASFP 500



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 167/710 (23%), Positives = 229/710 (32%), Gaps = 171/710 (24%)

Query: 48  AAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVCEALLQAGHAGRL 107
           A AGA A   AA A G  +P  PGSP       P  LR     V     A+ +   A R 
Sbjct: 8   AKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALR-----VLGAAGAVGRKPLAERA 62

Query: 108 SRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLE-------------SRPFPA 154
               GA  P    R      R     A  RGE A   +                +RP P 
Sbjct: 63  GGIGGATIPESAPRAGPT--RTSRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPL 120

Query: 155 AHHAF---LQDLYLRARYHEAERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKER 211
                    ++   R +  EA +    + GA    R     P P T             R
Sbjct: 121 GQKGLRISAEETVARGKATEAPKRSALSAGA----RRDTSGPTPGT------PSPAMARR 170

Query: 212 SRAA-------LKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNR--------RQRD 256
           SRAA         A     R PT   ++ +++ +  S T+ S   + R        R   
Sbjct: 171 SRAAGTEVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPAS 230

Query: 257 RTGAGGGAPCKSESDGNPTTEDE-------SSRSPEDLE-----------RGAAPVSAEA 298
           R+ +    P  S +   P+           S   P+ L+           + AAP     
Sbjct: 231 RSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPL 290

Query: 299 AAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGP 358
           ++      + + PP+P  A  S+    S  A   S A    G P +    +   +  L P
Sbjct: 291 SSSPLATPSPSAPPSPS-APPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSP 349

Query: 359 LLLTGGGGAPPPQ-------------PSPQGASETKTSLVLDPQTGE---VRLEEAQSEA 402
           L        PPPQ             PSP  +          PQ      V L +A    
Sbjct: 350 L------ATPPPQAPPALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSP 403

Query: 403 PETKGAQV-------------AAPGPALGEEVLGPLAQVVPGPPTA-----ATFPLPPGP 444
           P +   Q              A P       +  P  QV P PP +     +  P P  P
Sbjct: 404 PPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 463

Query: 445 VPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSP 504
            P +AAP +    PPP  P  L+ T PL  LP           P A  P Q     P S 
Sbjct: 464 PP-LAAPPLQLAKPPPQAPPALA-TPPLQALPS----------PPASFPGQ----APFS- 506

Query: 505 VKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILT 564
                                     PSA+ P + L   P    P++    +Q    +  
Sbjct: 507 --------------------------PSASLPMSPLATPPPQAPPVLAAPLLQ----VPP 536

Query: 565 ATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHA-LGTLSAQQPP 623
           +   +  L +   PP PG      P+T++S P   L +AP P  P + +   TLS   P 
Sbjct: 537 SPPASPTLQAPRRPPTPG------PDTSVSGPRLTLALAPGPPPPPSRSPSSTLSG--PD 588

Query: 624 PAAATTSSTSLP-----FSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAG 668
            A  ++S+TS P     +     G     P P  E     PAA   WS G
Sbjct: 589 LAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAACHPAA---WSRG 635


>gi|47132519 Ras association and pleckstrin homology domains 1
           isoform 1 [Homo sapiens]
          Length = 1250

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 86/326 (26%), Positives = 110/326 (33%), Gaps = 69/326 (21%)

Query: 368 PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGE------EV 421
           PPP PS    S    + +    +   RL+ A   +    GA    P P + +      ++
Sbjct: 646 PPPLPSQSAPSAGSAAPMFVKYSTITRLQNASQHS----GALFKPPTPPVMQSQSVKPQI 701

Query: 422 LGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPL--------- 472
           L P   VVP PP     P PP P P  A  Q+ P    P  P   +P  PL         
Sbjct: 702 LVPPNGVVPPPP-----PPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQVQHIT 756

Query: 473 --------------LNLPQVVPTSQVVTLP-----QAVGPLQLLAA--GPGSPVKVAAAA 511
                           LP   P   +VT+P     + V P+   AA   P  PV  A   
Sbjct: 757 QVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQ 816

Query: 512 GPANVHLINSGVGVTALQLPSATAP--GNFLLANPVSGSPIVTGVAVQQGKIILTATFPT 569
                  I        + +P  T P   +F    P S    V  V  Q          P 
Sbjct: 817 PAFPASYIPPSPPTPPVPVPPPTLPKQQSFCAKPPPSPLSPVPSVVKQIASQFPPPPTPP 876

Query: 570 SMLVSQVLPPAPGLALPLKPETAISVPE---GGLPVAPSPALPEAHALGTLSAQQPPPAA 626
           +M  SQ L P P    P  P    + P+     +PV PSP  P            PPP  
Sbjct: 877 AM-ESQPLKPVPANVAPQSPPAVKAKPKWQPSSIPV-PSPDFP------------PPP-- 920

Query: 627 ATTSSTSLPFSPDSPGLLPNFPAPPP 652
                +SL F P  P  +P  P PPP
Sbjct: 921 ---PESSLVFPPPPPSPVPAPPPPPP 943



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 86/362 (23%), Positives = 118/362 (32%), Gaps = 62/362 (17%)

Query: 352  EASSLGP-LLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKG--- 407
            ++ S+ P +L+   G  PPP P P   +       L P      L +  +  P  K    
Sbjct: 693  QSQSVKPQILVPPNGVVPPPPPPPPPPTPGSAMAQLKPAPCAPSLPQFSAPPPPLKIHQV 752

Query: 408  ---AQVAAPGPALGEEVLGPLAQVVPGPP---------TAATFPLPPGPVPAVAAPQVVP 455
                QVA P P     +  PL    P  P         T    P+     P    P V P
Sbjct: 753  QHITQVAPPTPPPPPPIPAPLPPQAPPKPLVTIPAPTSTKTVAPVVTQAAPPTPTPPVPP 812

Query: 456  LSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPAN 515
                P +P    P SP        PT  V   P  +   Q   A P           P+ 
Sbjct: 813  AKKQPAFPASYIPPSP--------PTPPVPVPPPTLPKQQSFCAKP----------PPSP 854

Query: 516  VHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTAT--FPTSMLV 573
            +  + S V   A Q P    P   + + P+   P+   VA Q    +       P+S+ V
Sbjct: 855  LSPVPSVVKQIASQFPPPPTP-PAMESQPL--KPVPANVAPQSPPAVKAKPKWQPSSIPV 911

Query: 574  -SQVLPPAP---GLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSA-------QQP 622
             S   PP P    L  P  P + +  P    P   SP   ++ + G  ++       ++P
Sbjct: 912  PSPDFPPPPPESSLVFPPPPPSPVPAPPPPPPPTASPTPDKSGSPGKKTSKTSSPGGKKP 971

Query: 623  PPAAATTSSTSL--------PFSPDSPGLLPNFPAPPPEGL----MLSPAAVPVWSAGLE 670
            PP     SS           P  P    L+  F  P   G      L P A P     L 
Sbjct: 972  PPTPQRNSSIKSSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLN 1031

Query: 671  LS 672
            LS
Sbjct: 1032 LS 1033



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 70/296 (23%), Positives = 104/296 (35%), Gaps = 23/296 (7%)

Query: 366 GAPPPQPSPQGASETKTSLVLDPQTGE-VRLEEAQSEAPETKGAQVAAPGPALGEE--VL 422
           G    QP+    S++  S V         +LEE+     E+      +  P L  +  ++
Sbjct: 557 GVSDTQPAGHVRSQSIVSSVFSEAWKRGTQLEESSKARMESMNRPYTSLVPPLSPQPKIV 616

Query: 423 GPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTS 482
            P     P PP      LPP P P    P   P  PPP  P+  +P++     P  V  S
Sbjct: 617 TPYTASQPSPP------LPPPPPPPPPPPPPPP-PPPPPLPSQSAPSAGSA-APMFVKYS 668

Query: 483 QVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLL- 541
            +  L  A      L   P  PV  + +  P  + +  +GV       P    PG+ +  
Sbjct: 669 TITRLQNASQHSGALFKPPTPPVMQSQSVKP-QILVPPNGVVPPPPPPPPPPTPGSAMAQ 727

Query: 542 ANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLP 601
             P   +P +   +     + +      + +     PP P +  PL P+     P   L 
Sbjct: 728 LKPAPCAPSLPQFSAPPPPLKIHQVQHITQVAPPTPPPPPPIPAPLPPQ----APPKPLV 783

Query: 602 VAPSPALPEAHALGTLSAQQP---PPAAATTSSTSLPFS--PDSPGLLPNFPAPPP 652
             P+P   +  A     A  P   PP        + P S  P SP   P  P PPP
Sbjct: 784 TIPAPTSTKTVAPVVTQAAPPTPTPPVPPAKKQPAFPASYIPPSPP-TPPVPVPPP 838



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 83/361 (22%), Positives = 127/361 (35%), Gaps = 49/361 (13%)

Query: 369  PPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQV 428
            PP P+P        S  L P    V  +   +   + K    + P P+       P + +
Sbjct: 870  PPPPTPPAME----SQPLKPVPANVAPQSPPAVKAKPKWQPSSIPVPSPDFPPPPPESSL 925

Query: 429  VPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYPTGLS--------PTSPLLNLPQVVP 480
            V  PP  +  P PP P P  A+P     S  PG  T  +        P +P  N    + 
Sbjct: 926  VFPPPPPSPVPAPPPPPPPTASP-TPDKSGSPGKKTSKTSSPGGKKPPPTPQRN--SSIK 982

Query: 481  TSQVVTLPQAVGPL--QLLA-----AGPGSPVKVAA---AAGPANVHLINSGVGVTALQL 530
            +S     P+   P    L++     A  GSP K      AA P    L  SGV +     
Sbjct: 983  SSSGAEHPEPKRPSVDSLVSKFTPPAESGSPSKETLPPPAAPPKPGKLNLSGVNL----- 1037

Query: 531  PSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPE 590
                 PG        + +P+++G    +GK  +   FP+    S   PP P   LPL P 
Sbjct: 1038 -----PGVLQQGCVSAKAPVLSG----RGKDSVVE-FPSPPSDSDFPPPPPETELPLPPI 1087

Query: 591  TAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPA-------AATTSSTSLPFSPDSPGL 643
               +V  G      +   P+      +S ++ PP        +   +   +   P    +
Sbjct: 1088 EIPAVFSGNTSPKVAVVNPQPQQWSKMSVKKAPPPTRPKRNDSTRLTQAEISEQPTMATV 1147

Query: 644  LPNFPAPPPEGLMLSPAAVPVWSAGLELSAGT-EGLLEAEKGLG-TQAPHTVLRLPDPDP 701
            +P  P  P   L + P  +   +  L+  + T  G L +        A    + LP P P
Sbjct: 1148 VPQVPTSPKSSLSVQPGFLADLNRTLQRKSITRHGSLSSRMSRAEPTATMDDMALPPPPP 1207

Query: 702  E 702
            E
Sbjct: 1208 E 1208


>gi|33286442 BCL6 co-repressor-like 1 [Homo sapiens]
          Length = 1711

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 106/420 (25%), Positives = 163/420 (38%), Gaps = 53/420 (12%)

Query: 311 PPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPP 370
           PPAP  AS    V  +F      PA + + G V +  +A    +   PL       AP P
Sbjct: 205 PPAPGSASVPHSVPDAFQVPLSVPAPVPHSGLVPVQ-VATSVPAPSPPL-------APVP 256

Query: 371 QPSPQGASETKTSLVLDPQTGEVR---LEEAQSEAPETKGAQVAAPGPA-LGEEVLGPLA 426
             +P  A  +  +L+ D     V    L    + AP +    ++AP PA L   V  P  
Sbjct: 257 ALAP--APPSVPTLISDSNPLSVSASVLVPVPASAPPSGPVPLSAPAPAPLSVPVSAPPL 314

Query: 427 QVV--PGPPTAATFPLPPGPVPAVA-----APQVVPLSPPPGYPTGLSPTSPLLNLPQVV 479
            ++  P PP+A T  L P P P +A      P   P  P    PT  +P+S   + P ++
Sbjct: 315 ALIQAPVPPSAPTLVLAPVPTPVLAPMPASTPPAAPAPPSVPMPTP-TPSSGPPSTPTLI 373

Query: 480 PTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNF 539
           P      +P A  P  +    P +P+  A  A       I +   ++ +  P+A AP   
Sbjct: 374 PAFAPTPVP-APTPAPIFTPAP-TPMPAATPAAIPTSAPIPASFSLSRVCFPAAQAPA-- 429

Query: 540 LLANPVS---------GSPIVTGVAVQQGKIILTATFPTSMLVSQ--VLPPAPGLALPLK 588
           +   P+S           P+V       G+ +  AT PT++ VS    LP  P       
Sbjct: 430 MQKVPLSFQPGTVLTPSQPLVYIPPPSCGQPLSVATLPTTLGVSSTLTLPVLPSYLQDRC 489

Query: 589 PETAISVPE-GGLPVAPSPALP--EAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLP 645
               ++ PE    P A S A P      L +L   + P  + + S+T+ P     PG L 
Sbjct: 490 LPGVLASPELRSYPYAFSVARPLTSDSKLVSLEVNRLPCTSPSGSTTTQPAPDGVPGPLA 549

Query: 646 NFP--------APPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHTVLRLP 697
           +           P P+ L+ +P+         ++ +GTE   E     GT    + L+ P
Sbjct: 550 DTSLVTASAKVLPTPQPLLPAPSGSSAPPHPAKMPSGTEQQTE-----GTSVTFSPLKSP 604


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 106/409 (25%), Positives = 143/409 (34%), Gaps = 106/409 (25%)

Query: 353 ASSLGPLLLTGGGGAPPPQP----SPQGASETKTSLVLDPQTG----EVRLEEAQSEAPE 404
           A+S  P L  GG   PP  P    SP     +++     P  G         +AQ   PE
Sbjct: 555 ANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTLPPKGLAGPPASPGKAQPPKPE 614

Query: 405 ------TKGAQVAAPGPALGEEVLGPLAQVVPGP----PTAATFPLPPGP-VPAVAAPQV 453
                 + GA V++   +L      P      GP    P    F +PP P VPA      
Sbjct: 615 RVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTPLGDRFVIPPHPKVPA------ 668

Query: 454 VPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGP 513
            P SPPP  P   +P +P L  P VVP           GP+    A P SP        P
Sbjct: 669 -PFSPPPSKPRSPNPAAPALAAPAVVP-----------GPVSTTDASPQSPPTPQTTLTP 716

Query: 514 ANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLV 573
                +     ++  Q P  + P ++    P +  P    V V+      TA  P   L 
Sbjct: 717 -----LQESPVISKDQSPPPSPPPSYHPPPPPTKKP---EVVVEAPSASETAEEP---LQ 765

Query: 574 SQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQP----------- 622
               PP P    P  PE      E  L +A  P  P   A  ++++ +P           
Sbjct: 766 DPNWPPPP----PPAPE------EQDLSMADFP--PPEEAFFSVASPEPAGPSGSPELVS 813

Query: 623 PPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAE 682
            PAA+++S+T+L   P      P  P PPP      PA  P                   
Sbjct: 814 SPAASSSSATALQIQP------PGSPDPPP----APPAPAP------------------- 844

Query: 683 KGLGTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSV 731
               + AP  V +LP  +P G   G   GG   E + A     + LQ V
Sbjct: 845 ---ASSAPGHVAKLPQKEPVGCSKG---GGPPREDVGAPLVTPSLLQMV 887



 Score = 38.1 bits (87), Expect = 0.030
 Identities = 75/332 (22%), Positives = 112/332 (33%), Gaps = 46/332 (13%)

Query: 292  APVSAEAAAQGSIFLAGTGPPAPCPASSSILV-------NGSFLAASGSPAVLLNGGPVI 344
            AP ++E A +         PP P P    + +          F  AS  PA   +G P +
Sbjct: 753  APSASETAEEPLQDPNWPPPPPPAPEEQDLSMADFPPPEEAFFSVASPEPAGP-SGSPEL 811

Query: 345  INGLALGEASSLGPLLLTGGGGAPPP-QPSPQGASETKTSLVLDPQTGEVRLEEAQSEAP 403
            ++  A   +S+    +   G   PPP  P+P  AS     +   PQ   V   +      
Sbjct: 812  VSSPAASSSSATALQIQPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPR 871

Query: 404  ETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP-LPPGPVPAVAAPQVVPLSPPPGY 462
            E  GA +    P+L + V         G PT A  P  P  P+    + +    SP P  
Sbjct: 872  EDVGAPLVT--PSLLQMVRLRSVGAPGGAPTPALGPSAPQKPLRRALSGRA---SPVPAP 926

Query: 463  PTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSG 522
             +GL     L      +  S+ ++  Q  GP +     P SP   A+             
Sbjct: 927  SSGLHAAVRLKACS--LAASEGLSSAQPNGPPEAEPRPPQSPASTAS---------FIFS 975

Query: 523  VGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPG 582
             G   LQL    +P               T   +Q+  +    +      +S+  PP   
Sbjct: 976  KGSRKLQLERPVSP--------------ETQADLQRNLVAELRS------ISEQRPPQAP 1015

Query: 583  LALPLKPETAISVPEGGLPVAPSPALPEAHAL 614
               P  P      P  G+P   SP+ P A  L
Sbjct: 1016 KKSPKAPPPVARKPSVGVPPPASPSYPRAEPL 1047



 Score = 36.6 bits (83), Expect = 0.086
 Identities = 29/89 (32%), Positives = 37/89 (41%), Gaps = 9/89 (10%)

Query: 577 LPPAPGLA----LPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSST 632
           LPP P       LP  P T  S   G  P  P+PA      L    +++PP +   T S 
Sbjct: 521 LPPKPERKQQPQLPRPPTTGGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSP 580

Query: 633 SLPFSPDSPGLLPNFPAPPPEGLMLSPAA 661
           S  +S  S       P  PP+GL   PA+
Sbjct: 581 SSGYSSQS-----GTPTLPPKGLAGPPAS 604



 Score = 33.1 bits (74), Expect = 0.95
 Identities = 37/146 (25%), Positives = 54/146 (36%), Gaps = 17/146 (11%)

Query: 578 PPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFS 637
           PP P        +  ++VP+G L + P P   +   L      +PP    +  + + P  
Sbjct: 497 PPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQL-----PRPPTTGGSEGAGAAPCP 551

Query: 638 PDS-----PGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGTQAPHT 692
           P+      PGL P     PP     SP      S+G    +GT  L    KGL    P +
Sbjct: 552 PNPANSWVPGLSPGGSRRPPR----SPERTLSPSSGYSSQSGTPTL--PPKGL-AGPPAS 604

Query: 693 VLRLPDPDPEGLLLGATAGGEVDEGL 718
             +   P PE +    + G  V   L
Sbjct: 605 PGKAQPPKPERVTSLRSPGASVSSSL 630


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 83/318 (26%), Positives = 112/318 (35%), Gaps = 50/318 (15%)

Query: 368 PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGA---QVAAPGPALGEEVL-- 422
           P PQ +   +  +    +L  Q   ++     + AP +      Q+  PGP      +  
Sbjct: 162 PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 221

Query: 423 --GPLAQVVPGPPTAATFPLPPGPVPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQV 478
              P A   P  P A T P+P   +    A  PQ  P   PP +P+   P  PL      
Sbjct: 222 QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS--- 278

Query: 479 VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGN 538
                    P A    Q    G G P   +  AGP    L+          LP   + G 
Sbjct: 279 ------AGQPSAPSHAQPPLHGQGPPGPHSLQAGP----LLQHPGPPQPFGLPPQASQGQ 328

Query: 539 FLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALP-LKPETAISVPE 597
             L    + +   T + +   +  L +  P      Q LPPAP LA+P +KP     +P+
Sbjct: 329 APLGTSPAAAYPHTSLQLPASQSALQSQQPPR---EQPLPPAP-LAMPHIKPPPTTPIPQ 384

Query: 598 GGLPVA---------PSPA-----LPEAHALGTLSA--------QQPPPAAATTSSTSLP 635
              P A         PSP      LP   AL  LS+          PPP      S  LP
Sbjct: 385 LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLP 444

Query: 636 FSP-DSPGLLPNFPAPPP 652
            SP   PGL  +   PPP
Sbjct: 445 SSPAQPPGLTQSQNLPPP 462



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 96/384 (25%), Positives = 125/384 (32%), Gaps = 73/384 (19%)

Query: 272 GNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP-PAPCPASSSILVNGSFLAA 330
           G+PT    +S++P   +   APV      Q         P P P P  S          +
Sbjct: 223 GSPT----ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS 278

Query: 331 SGSPAVLLNGGPVIINGLALGEAS-SLGPLLLTGGGGAP---PPQPSPQGASETKTSLVL 386
           +G P+   +  P +      G  S   GPLL   G   P   PPQ S QG +   TS   
Sbjct: 279 AGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQAS-QGQAPLGTSPAA 337

Query: 387 DPQTGEVRLEEAQS--EAPETKGAQVAAPGPALGEEVLGPLAQVVPG------------- 431
                 ++L  +QS  ++ +    Q   P P     +  P    +P              
Sbjct: 338 AYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHL 397

Query: 432 ------------PPTAATFPL-------PPG--PVPAVAAPQVVPLSPPPGYPTGLSPTS 470
                       PP  A  PL       PP   P P    PQ  PL   P  P GL+ + 
Sbjct: 398 SGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQ 457

Query: 471 PLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQL 530
              NLP   P S   T    V P    A  P  P       GP           +T    
Sbjct: 458 ---NLPP-PPASHPPTGLHQVAPQPPFAQHPFVP------GGPP---------PITPPTC 498

Query: 531 PSATAPGNFLLANP-VSGSPIVTGVAVQQGKII--LTATFPTSMLVSQVLPPAPGLALPL 587
           PS + P     A P  S  P  +G A   G I    +   PT  +  + L  A     P 
Sbjct: 499 PSTSTPP----AGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP 554

Query: 588 KPETAISVPEGGLPVAPSPALPEA 611
            P  + S PE  +   PS A   A
Sbjct: 555 PPPRSPS-PEPTVVDTPSHASQSA 577



 Score = 30.0 bits (66), Expect = 8.1
 Identities = 38/150 (25%), Positives = 51/150 (34%), Gaps = 12/150 (8%)

Query: 568 PTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAA 627
           P ++     + PAP  A P  P+     P       P    P A    + +  QP    A
Sbjct: 184 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTA----SQAPNQPQAPTA 239

Query: 628 TTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGT 687
               T +  +P      P  P PPP      P      SAG + SA +        G G 
Sbjct: 240 PVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAG-QPSAPSHAQPPLH-GQGP 297

Query: 688 QAPHTVLRLP------DPDPEGLLLGATAG 711
             PH++   P       P P GL   A+ G
Sbjct: 298 PGPHSLQAGPLLQHPGPPQPFGLPPQASQG 327


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 83/318 (26%), Positives = 112/318 (35%), Gaps = 50/318 (15%)

Query: 368  PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGA---QVAAPGPALGEEVL-- 422
            P PQ +   +  +    +L  Q   ++     + AP +      Q+  PGP      +  
Sbjct: 716  PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 775

Query: 423  --GPLAQVVPGPPTAATFPLPPGPVPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQV 478
               P A   P  P A T P+P   +    A  PQ  P   PP +P+   P  PL      
Sbjct: 776  QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS--- 832

Query: 479  VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGN 538
                     P A    Q    G G P   +  AGP    L+          LP   + G 
Sbjct: 833  ------AGQPSAPSHAQPPLHGQGPPGPHSLQAGP----LLQHPGPPQPFGLPPQASQGQ 882

Query: 539  FLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALP-LKPETAISVPE 597
              L    + +   T + +   +  L +  P      Q LPPAP LA+P +KP     +P+
Sbjct: 883  APLGTSPAAAYPHTSLQLPASQSALQSQQPPR---EQPLPPAP-LAMPHIKPPPTTPIPQ 938

Query: 598  GGLPVA---------PSPA-----LPEAHALGTLSA--------QQPPPAAATTSSTSLP 635
               P A         PSP      LP   AL  LS+          PPP      S  LP
Sbjct: 939  LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLP 998

Query: 636  FSP-DSPGLLPNFPAPPP 652
             SP   PGL  +   PPP
Sbjct: 999  SSPAQPPGLTQSQNLPPP 1016



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 96/384 (25%), Positives = 125/384 (32%), Gaps = 73/384 (19%)

Query: 272  GNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP-PAPCPASSSILVNGSFLAA 330
            G+PT    +S++P   +   APV      Q         P P P P  S          +
Sbjct: 777  GSPT----ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS 832

Query: 331  SGSPAVLLNGGPVIINGLALGEAS-SLGPLLLTGGGGAP---PPQPSPQGASETKTSLVL 386
            +G P+   +  P +      G  S   GPLL   G   P   PPQ S QG +   TS   
Sbjct: 833  AGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQAS-QGQAPLGTSPAA 891

Query: 387  DPQTGEVRLEEAQS--EAPETKGAQVAAPGPALGEEVLGPLAQVVPG------------- 431
                  ++L  +QS  ++ +    Q   P P     +  P    +P              
Sbjct: 892  AYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHL 951

Query: 432  ------------PPTAATFPL-------PPG--PVPAVAAPQVVPLSPPPGYPTGLSPTS 470
                        PP  A  PL       PP   P P    PQ  PL   P  P GL+ + 
Sbjct: 952  SGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQ 1011

Query: 471  PLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQL 530
               NLP   P S   T    V P    A  P  P       GP           +T    
Sbjct: 1012 ---NLPP-PPASHPPTGLHQVAPQPPFAQHPFVP------GGPP---------PITPPTC 1052

Query: 531  PSATAPGNFLLANP-VSGSPIVTGVAVQQGKII--LTATFPTSMLVSQVLPPAPGLALPL 587
            PS + P     A P  S  P  +G A   G I    +   PT  +  + L  A     P 
Sbjct: 1053 PSTSTPP----AGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP 1108

Query: 588  KPETAISVPEGGLPVAPSPALPEA 611
             P  + S PE  +   PS A   A
Sbjct: 1109 PPPRSPS-PEPTVVDTPSHASQSA 1131



 Score = 30.0 bits (66), Expect = 8.1
 Identities = 38/150 (25%), Positives = 51/150 (34%), Gaps = 12/150 (8%)

Query: 568 PTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAA 627
           P ++     + PAP  A P  P+     P       P    P A    + +  QP    A
Sbjct: 738 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTA----SQAPNQPQAPTA 793

Query: 628 TTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGT 687
               T +  +P      P  P PPP      P      SAG + SA +        G G 
Sbjct: 794 PVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAG-QPSAPSHAQPPLH-GQGP 851

Query: 688 QAPHTVLRLP------DPDPEGLLLGATAG 711
             PH++   P       P P GL   A+ G
Sbjct: 852 PGPHSLQAGPLLQHPGPPQPFGLPPQASQG 881


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 60.5 bits (145), Expect = 6e-09
 Identities = 83/318 (26%), Positives = 112/318 (35%), Gaps = 50/318 (15%)

Query: 368  PPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGA---QVAAPGPALGEEVL-- 422
            P PQ +   +  +    +L  Q   ++     + AP +      Q+  PGP      +  
Sbjct: 716  PSPQDNESDSDSSAQQQMLQAQPPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPP 775

Query: 423  --GPLAQVVPGPPTAATFPLPPGPVPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQV 478
               P A   P  P A T P+P   +    A  PQ  P   PP +P+   P  PL      
Sbjct: 776  QGSPTASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS--- 832

Query: 479  VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGN 538
                     P A    Q    G G P   +  AGP    L+          LP   + G 
Sbjct: 833  ------AGQPSAPSHAQPPLHGQGPPGPHSLQAGP----LLQHPGPPQPFGLPPQASQGQ 882

Query: 539  FLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLALP-LKPETAISVPE 597
              L    + +   T + +   +  L +  P      Q LPPAP LA+P +KP     +P+
Sbjct: 883  APLGTSPAAAYPHTSLQLPASQSALQSQQPPR---EQPLPPAP-LAMPHIKPPPTTPIPQ 938

Query: 598  GGLPVA---------PSPA-----LPEAHALGTLSA--------QQPPPAAATTSSTSLP 635
               P A         PSP      LP   AL  LS+          PPP      S  LP
Sbjct: 939  LPAPQAHKHPPHLSGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLP 998

Query: 636  FSP-DSPGLLPNFPAPPP 652
             SP   PGL  +   PPP
Sbjct: 999  SSPAQPPGLTQSQNLPPP 1016



 Score = 35.8 bits (81), Expect = 0.15
 Identities = 96/384 (25%), Positives = 125/384 (32%), Gaps = 73/384 (19%)

Query: 272  GNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGP-PAPCPASSSILVNGSFLAA 330
            G+PT    +S++P   +   APV      Q         P P P P  S          +
Sbjct: 777  GSPT----ASQAPNQPQAPTAPVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGS 832

Query: 331  SGSPAVLLNGGPVIINGLALGEAS-SLGPLLLTGGGGAP---PPQPSPQGASETKTSLVL 386
            +G P+   +  P +      G  S   GPLL   G   P   PPQ S QG +   TS   
Sbjct: 833  AGQPSAPSHAQPPLHGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQAS-QGQAPLGTSPAA 891

Query: 387  DPQTGEVRLEEAQS--EAPETKGAQVAAPGPALGEEVLGPLAQVVPG------------- 431
                  ++L  +QS  ++ +    Q   P P     +  P    +P              
Sbjct: 892  AYPHTSLQLPASQSALQSQQPPREQPLPPAPLAMPHIKPPPTTPIPQLPAPQAHKHPPHL 951

Query: 432  ------------PPTAATFPL-------PPG--PVPAVAAPQVVPLSPPPGYPTGLSPTS 470
                        PP  A  PL       PP   P P    PQ  PL   P  P GL+ + 
Sbjct: 952  SGPSPFSMNANLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQPLPSSPAQPPGLTQSQ 1011

Query: 471  PLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQL 530
               NLP   P S   T    V P    A  P  P       GP           +T    
Sbjct: 1012 ---NLPP-PPASHPPTGLHQVAPQPPFAQHPFVP------GGPP---------PITPPTC 1052

Query: 531  PSATAPGNFLLANP-VSGSPIVTGVAVQQGKII--LTATFPTSMLVSQVLPPAPGLALPL 587
            PS + P     A P  S  P  +G A   G I    +   PT  +  + L  A     P 
Sbjct: 1053 PSTSTPP----AGPGTSAQPPCSGAAASGGSIAGGSSCPLPTVQIKEEALDDAEEPESPP 1108

Query: 588  KPETAISVPEGGLPVAPSPALPEA 611
             P  + S PE  +   PS A   A
Sbjct: 1109 PPPRSPS-PEPTVVDTPSHASQSA 1131



 Score = 30.0 bits (66), Expect = 8.1
 Identities = 38/150 (25%), Positives = 51/150 (34%), Gaps = 12/150 (8%)

Query: 568 PTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAA 627
           P ++     + PAP  A P  P+     P       P    P A    + +  QP    A
Sbjct: 738 PPALQAPTGVTPAPSSAPPGTPQLPTPGPTPSATAVPPQGSPTA----SQAPNQPQAPTA 793

Query: 628 TTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAGTEGLLEAEKGLGT 687
               T +  +P      P  P PPP      P      SAG + SA +        G G 
Sbjct: 794 PVPHTHIQQAPALHPQRPPSPHPPPHPSPHPPLQPLTGSAG-QPSAPSHAQPPLH-GQGP 851

Query: 688 QAPHTVLRLP------DPDPEGLLLGATAG 711
             PH++   P       P P GL   A+ G
Sbjct: 852 PGPHSLQAGPLLQHPGPPQPFGLPPQASQG 881


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 116/496 (23%), Positives = 161/496 (32%), Gaps = 73/496 (14%)

Query: 277  EDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAV 336
            ED ++ +    ER   P    +  +G+  +A    P                 A    A 
Sbjct: 894  EDVTAAAVSAPERATVPAVTVSVPEGTAAVAAVSSPEE--------------TAPAVAAA 939

Query: 337  LLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLE 396
            +   G   + G +   A+    + +T   G P    +P     T      +P T  VR+ 
Sbjct: 940  ITQEGMSAVAGFSPEWAALAITVPITEEDGTPEGPVTPA----TTVHAPEEPDTAAVRV- 994

Query: 397  EAQSEAPETKGAQVAAPGPALGEEVLGPLAQV-VPGPPTAATFPLPP-----GPVPAVAA 450
             +  E P +  A V  P     EE   P A V  P  PT+    +PP      P  AV  
Sbjct: 995  -STPEEPASPAAAVPTP-----EEPTSPAAAVPTPEEPTSPAAAVPPPEEPTSPAAAVPT 1048

Query: 451  PQVVPLSPPPGYPTGLSPTSPLLNLP---------QVVPTSQVVTLPQAVGPLQLLAAGP 501
            P+  P SP    PT   PTSP   +P           VPT +  T P A  P       P
Sbjct: 1049 PEE-PTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSP 1107

Query: 502  GSPVKV------AAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVA 555
             + V         AAA P      +    V   + P+  AP    +  P   +     V 
Sbjct: 1108 AAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPA---VPTPEESASAAVAVP 1164

Query: 556  VQQGKIILTATFPTSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPE--AHA 613
              +      A  PT    +        L  P  P  A SVP    P A    L E  + A
Sbjct: 1165 TPEESASPAAAVPTPAESASFAAVVATLEEPTSP--AASVP---TPAAMVATLEEFTSPA 1219

Query: 614  LGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAP--------PPEGLMLSPAAVPVW 665
                ++++P   AA  S+   P SP     +P    P         PE L    A+VP  
Sbjct: 1220 ASVPTSEEPASLAAAVSNPEEPTSP--AAAVPTLEEPTSSAAAVLTPEELSSPAASVPTP 1277

Query: 666  SAGLELSAGTEGLLEAEKGLGTQAPHTVLRLPD---PDPEGLLLGATAGGEVDEGLEAEA 722
                  +A    L E            V  +P    P PE   + A A   ++E      
Sbjct: 1278 EEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPEVPAIPAAAVPPMEEVSPIGV 1337

Query: 723  KVL---TQLQSVPVEE 735
              L       SVP+ E
Sbjct: 1338 PFLGVSAHTDSVPISE 1353


>gi|239742468 PREDICTED: double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%)

Query: 43  EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98
           +G  A      AG  AA A       V GSPP +    P+ ++F P   A       ++ 
Sbjct: 13  QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71

Query: 99  LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153
           L A   GR  R      P++        LRA     F+R  Y   A   RL ++   P P
Sbjct: 72  LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122

Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208
                F  +   + R H  E       RG   G       R+K    +T   G +T    
Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167

Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268
                A L   +  +R+P    +  LA  TGL  +++  WF+NRR R   G GG AP ++
Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221

Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327
              G   +       P       AP     A  G+    GTG PAP  P +   L  G+F
Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268

Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387
           ++ +   A      P +    A        P    G      P P P GA     +    
Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321

Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444
           P  G+ R +             VA PGPA      GP  Q V  PPT+   P      GP
Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377

Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488
             A AA  PQ     PP   P   S ++    +  +   SQ +  P
Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423


>gi|194272172 double homeobox, 4 [Homo sapiens]
          Length = 485

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%)

Query: 43  EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98
           +G  A      AG  AA A       V GSPP +    P+ ++F P   A       ++ 
Sbjct: 13  QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71

Query: 99  LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153
           L A   GR  R      P++        LRA     F+R  Y   A   RL ++   P P
Sbjct: 72  LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122

Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208
                F  +   + R H  E       RG   G       R+K    +T   G +T    
Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167

Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268
                A L   +  +R+P    +  LA  TGL  +++  WF+NRR R   G GG AP ++
Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221

Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327
              G   +       P       AP     A  G+    GTG PAP  P +   L  G+F
Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268

Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387
           ++ +   A      P +    A        P    G      P P P GA     +    
Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321

Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444
           P  G+ R +             VA PGPA      GP  Q V  PPT+   P      GP
Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377

Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488
             A AA  PQ     PP   P   S ++    +  +   SQ +  P
Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423


>gi|163914392 glioma tumor suppressor candidate region gene 1 [Homo
           sapiens]
          Length = 1560

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 116/433 (26%), Positives = 155/433 (35%), Gaps = 91/433 (21%)

Query: 307 AGTGPPAPCP-ASSSILVNGSFLAA----SGSPAVLLNGGPVIINGLALGEAS---SLGP 358
           +  GP  P   AS+ +   G+ L      S + A  LNG  V     A    +   S  P
Sbjct: 265 SAAGPSEPVTLASAGVSPQGAGLVIQKNLSAAVATTLNGNSVFGGAGAASAPTGTPSGQP 324

Query: 359 LLLTGGGGAPPPQPSPQ-------GASETKTSLVLDPQT------------------GEV 393
           L +  G G+ P  P+P           + K + VL P+                   GE 
Sbjct: 325 LAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKLYQLTPKPFAPAGATLTIQGEP 384

Query: 394 RLEEAQSEAPETKGAQVAA-----------PGPALGEEVLGPLAQVVPGPPTAATFPLPP 442
                Q +AP+      A            P PAL        A V   PP   T   PP
Sbjct: 385 GALPQQPKAPQNLTFMAAGKAGQNVVLSGFPAPALQ-------ANVFKQPPATTTGAAPP 437

Query: 443 GPVPAVAAPQVVPLSPP------------PGYPTGLSPTSPLLNLPQVVPTSQVVTLPQA 490
            P  A++ P  V L               PG    L P +P + LPQ     Q+  LP  
Sbjct: 438 QPPGALSKPMSVHLLNQGSSIVIPAQHMLPGQNQFLLPGAPAVQLPQ-----QLSALPAN 492

Query: 491 VGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFL-LANPVSGSP 549
           VG   L AA P +  ++ A     N +L         L L    AP +    A+ +S +P
Sbjct: 493 VGGQILAAAAPHTGGQLIANPILTNQNLAGP------LSLGPVLAPHSGAHSAHILSAAP 546

Query: 550 IVTGV-AVQQGKIILTA-TFPTSMLVSQVLPPAP-------GLALPLKPETAISVPEGGL 600
           I  G  A+ Q  + L A + PT    SQ  P  P       G+ LP      ++ P+G +
Sbjct: 547 IQVGQPALFQMPVSLAAGSLPTQ---SQPAPAGPAATTVLQGVTLPPSAVAMLNTPDGLV 603

Query: 601 -PVAPSPALPEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSP 659
            P  P+ A  EA  + T+   QP P A    ST LP     P       AP P+      
Sbjct: 604 QPATPAAATGEAAPVLTV---QPAPQAPPAVSTPLPLGLQQPQAQQPPQAPTPQAAAPPQ 660

Query: 660 AAVPVWSAGLELS 672
           A  P  S GL  S
Sbjct: 661 ATTPQPSPGLASS 673



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 105/411 (25%), Positives = 149/411 (36%), Gaps = 99/411 (24%)

Query: 367  APPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLA 426
            APPP   P  A+       L PQ  +       S+A      Q+ A  P  G        
Sbjct: 726  APPPAQDPAPATPVAKGAGLGPQAPD-------SQASPAPAPQIPAAAPLKG-------- 770

Query: 427  QVVPGPPTAATFP--LPPGPVPAVAAPQVV-PLSPPPGYPTGLS--PTSPLLNL---PQV 478
               PGP ++ + P   P G  P + +P    P S PP  P  +S  P+ P L+    PQ 
Sbjct: 771  ---PGPSSSPSLPHQAPLGDSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQA 827

Query: 479  VPTSQVVTL---------------PQAVGP----LQLLAAGPGSPVKVAAAAGPANVHLI 519
             PT   + +               P A GP    L+  +  P  P+  A    P++    
Sbjct: 828  PPTLPGIFVIQNQLGVPPPASNPAPTAPGPPQPPLRPQSQPPEGPLPPAPHLPPSSTSSA 887

Query: 520  NSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLVSQVLPP 579
             +    T+ +LP+ T P +F L  P S  P  +               PT  LV     P
Sbjct: 888  VASSSETSSRLPAPT-PSDFQLQFPPSQGPHKSPTPP-----------PTLHLV-----P 930

Query: 580  APGLALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQP-----------PPAAAT 628
             P    P  P T   V        P PALP+  AL     Q P            PAA  
Sbjct: 931  EPAAPPPPPPRTFQMV------TTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQ 984

Query: 629  TSSTSLPFSPDSPGLLPNFPAP--PPEGLMLSPAAVPVWSAGLELSAGTEGLLEAE-KGL 685
            TS++  P +  +  +L +  AP   P     +PA  P+ + GL        LL AE K  
Sbjct: 985  TSTSLGPLTSPAASVLVSGQAPSGTPTAPSHAPAPAPMAATGL------PPLLPAENKAF 1038

Query: 686  GTQAPHTVLRLPDPDPEGLLLGATAGGEVDEGLEAEAKVLTQLQSVPVEEP 736
             +  P             +   A++G     GL+ E+K L+ L+  P  +P
Sbjct: 1039 ASNLPTL----------NVAKAASSGPGKPSGLQYESK-LSGLKKPPTLQP 1078



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 109/451 (24%), Positives = 155/451 (34%), Gaps = 76/451 (16%)

Query: 269 ESDGNPTTEDESSRSPE-DLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSF 327
           E+ GN    + +  +P  DL+     +    A  G    +G G   PC      L   + 
Sbjct: 55  EASGNHLNPEPNQPAPSVDLDFLEDDILGSPATGGGGGGSG-GADQPCDILQQSLQEANI 113

Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387
              +      L+ GP  +  L   +  + GP   TG GGA      PQ      T L+  
Sbjct: 114 TEQTLEAEAELDLGPFQLPTLQPADGGA-GP---TGAGGAAAVAAGPQALFPGSTDLL-- 167

Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPG---- 443
                              G Q   P   L  + L P   VV    +   F  P G    
Sbjct: 168 -------------------GLQ--GPPTVLTHQALVPPQDVVNKALSVQPFLQPVGLGNV 206

Query: 444 ---PVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVV-----PTSQVVTLPQAVGPLQ 495
              P+P +   Q +P   P G        +P+  + Q V     PTSQ++     V    
Sbjct: 207 TLQPIPGL---QGLPNGSPGGATAATLGLAPIQVVGQPVMALNTPTSQLLAKQVPVSGYL 263

Query: 496 LLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVA 555
             AAGP  PV +A+A       +   G G+   +  SA       +A  ++G+ +  G  
Sbjct: 264 ASAAGPSEPVTLASAG------VSPQGAGLVIQKNLSAA------VATTLNGNSVFGGAG 311

Query: 556 VQQGKIILTATFPTSMLVSQVLPPAPGL-ALPLKPETAISVPEGGLPVAPSPALPEAHAL 614
                    A+ PT     Q L  APGL + PL P   + +     P+ P PA      L
Sbjct: 312 --------AASAPTGTPSGQPLAVAPGLGSSPLVPAPNVILHRTPTPIQPKPAGVLPPKL 363

Query: 615 GTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVPVWSAGLELSAG 674
             L+ +   PA AT +          PG LP  P  P     L+  A       + LS  
Sbjct: 364 YQLTPKPFAPAGATLTIQG------EPGALPQQPKAPQN---LTFMAAGKAGQNVVLSGF 414

Query: 675 TEGLLEAEKGLGTQAPHTVLRLPDPDPEGLL 705
               L+A   +  Q P T      P P G L
Sbjct: 415 PAPALQA--NVFKQPPATTTGAAPPQPPGAL 443



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 104/415 (25%), Positives = 146/415 (35%), Gaps = 80/415 (19%)

Query: 293 PVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGE 352
           PVS  A +     L     PAP   +++ ++ G  L  S     +LN    ++       
Sbjct: 558 PVSLAAGS-----LPTQSQPAPAGPAATTVLQGVTLPPSA--VAMLNTPDGLVQPATPAA 610

Query: 353 ASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPETKGAQVAA 412
           A+     +LT        QP+PQ      T L L  Q  + +      + P+    Q AA
Sbjct: 611 ATGEAAPVLT-------VQPAPQAPPAVSTPLPLGLQQPQAQ------QPPQAPTPQAAA 657

Query: 413 PGPALGEEVLGPLA----QVVPGPPTAAT--------------------FPLPP-GPVPA 447
           P  A   +    LA    ++V G P +AT                     PL   GP  +
Sbjct: 658 PPQATTPQPSPGLASSPEKIVLGQPPSATPTAILTQDSLQMFLPQERSQQPLSAEGPHLS 717

Query: 448 VAAPQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKV 507
           V A  +V   PP   P   +P +    L    P SQ    P    P      GPG     
Sbjct: 718 VPASVIVSAPPPAQDPAPATPVAKGAGLGPQAPDSQASPAPAPQIPAAAPLKGPG----- 772

Query: 508 AAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGS-----------------PI 550
             ++ P+  H    G     L  P  T P +   + P S S                 P 
Sbjct: 773 -PSSSPSLPHQAPLG-DSPHLPSPHPTRPPSRPPSRPQSVSRPPSEPPLHPCPPPQAPPT 830

Query: 551 VTGVAVQQGKIILTATFPTSMLVSQVLPPAPGLAL-PLKPETAISVPEGGLPVAPS-PAL 608
           + G+ V Q ++ +          S   P APG    PL+P++    PEG LP AP  P  
Sbjct: 831 LPGIFVIQNQLGVPPP------ASNPAPTAPGPPQPPLRPQS--QPPEGPLPPAPHLPPS 882

Query: 609 PEAHALGTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEGLMLSPAAVP 663
             + A+ + S       A T S   L F P S G   +   PP   L+  PAA P
Sbjct: 883 STSSAVASSSETSSRLPAPTPSDFQLQF-PPSQGPHKSPTPPPTLHLVPEPAAPP 936



 Score = 32.3 bits (72), Expect = 1.6
 Identities = 29/89 (32%), Positives = 38/89 (42%), Gaps = 20/89 (22%)

Query: 5   PAEPSAGPAAGG---------EAVAAAAATEEEEEEARQL------LQTLQAAEGEAAAA 49
           PA    G  +GG         +++  A  TE+  E   +L      L TLQ A+G A   
Sbjct: 85  PATGGGGGGSGGADQPCDILQQSLQEANITEQTLEAEAELDLGPFQLPTLQPADGGAGPT 144

Query: 50  AGAGAGAAAAGAEG--PGSP---GVPGSP 73
              GA A AAG +   PGS    G+ G P
Sbjct: 145 GAGGAAAVAAGPQALFPGSTDLLGLQGPP 173



 Score = 30.4 bits (67), Expect = 6.2
 Identities = 57/219 (26%), Positives = 75/219 (34%), Gaps = 43/219 (19%)

Query: 308  GTGPPAPC--PASSSILVNGSFLAASGSPAVLLNGGPVIINGLALGEASSLGP--LLLTG 363
            G  PPAP   P+S+S  V  S   +S  PA   +   +          S   P  L L  
Sbjct: 871  GPLPPAPHLPPSSTSSAVASSSETSSRLPAPTPSDFQLQFPPSQGPHKSPTPPPTLHLVP 930

Query: 364  GGGAPPPQPSPQGASETKTSLVLDPQTGEV--RLEEAQS------------EAPETKGAQ 409
               APPP P P+      T     PQ   +  R  +  S             AP+T  + 
Sbjct: 931  EPAAPPPPP-PRTFQMVTTPFPALPQPKALLERFHQVPSGIILQNKAGGAPAAPQTSTSL 989

Query: 410  VAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVAAPQVVP-------------- 455
                 PA    V G   Q   G PTA +    P P+ A   P ++P              
Sbjct: 990  GPLTSPAASVLVSG---QAPSGTPTAPSHAPAPAPMAATGLPPLLPAENKAFASNLPTLN 1046

Query: 456  ----LSPPPGYPTGLSPTSPLLNL---PQVVPTSQVVTL 487
                 S  PG P+GL   S L  L   P + P+ +   L
Sbjct: 1047 VAKAASSGPGKPSGLQYESKLSGLKKPPTLQPSKEACFL 1085


>gi|194272217 double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%)

Query: 43  EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98
           +G  A      AG  AA A       V GSPP +    P+ ++F P   A       ++ 
Sbjct: 13  QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71

Query: 99  LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153
           L A   GR  R      P++        LRA     F+R  Y   A   RL ++   P P
Sbjct: 72  LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122

Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208
                F  +   + R H  E       RG   G       R+K    +T   G +T    
Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167

Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268
                A L   +  +R+P    +  LA  TGL  +++  WF+NRR R   G GG AP ++
Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221

Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327
              G   +       P       AP     A  G+    GTG PAP  P +   L  G+F
Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268

Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387
           ++ +   A      P +    A        P    G      P P P GA     +    
Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321

Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444
           P  G+ R +             VA PGPA      GP  Q V  PPT+   P      GP
Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377

Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488
             A AA  PQ     PP   P   S ++    +  +   SQ +  P
Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423


>gi|194272216 double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%)

Query: 43  EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98
           +G  A      AG  AA A       V GSPP +    P+ ++F P   A       ++ 
Sbjct: 13  QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71

Query: 99  LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153
           L A   GR  R      P++        LRA     F+R  Y   A   RL ++   P P
Sbjct: 72  LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122

Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208
                F  +   + R H  E       RG   G       R+K    +T   G +T    
Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167

Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268
                A L   +  +R+P    +  LA  TGL  +++  WF+NRR R   G GG AP ++
Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221

Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327
              G   +       P       AP     A  G+    GTG PAP  P +   L  G+F
Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268

Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387
           ++ +   A      P +    A        P    G      P P P GA     +    
Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321

Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444
           P  G+ R +             VA PGPA      GP  Q V  PPT+   P      GP
Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377

Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488
             A AA  PQ     PP   P   S ++    +  +   SQ +  P
Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423


>gi|194272215 double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%)

Query: 43  EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98
           +G  A      AG  AA A       V GSPP +    P+ ++F P   A       ++ 
Sbjct: 13  QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71

Query: 99  LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153
           L A   GR  R      P++        LRA     F+R  Y   A   RL ++   P P
Sbjct: 72  LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122

Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208
                F  +   + R H  E       RG   G       R+K    +T   G +T    
Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167

Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268
                A L   +  +R+P    +  LA  TGL  +++  WF+NRR R   G GG AP ++
Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221

Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327
              G   +       P       AP     A  G+    GTG PAP  P +   L  G+F
Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268

Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387
           ++ +   A      P +    A        P    G      P P P GA     +    
Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321

Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444
           P  G+ R +             VA PGPA      GP  Q V  PPT+   P      GP
Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377

Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488
             A AA  PQ     PP   P   S ++    +  +   SQ +  P
Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423


>gi|194272192 double homeobox, 4-like [Homo sapiens]
          Length = 485

 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 122/466 (26%), Positives = 166/466 (35%), Gaps = 75/466 (16%)

Query: 43  EGEAAAAAGAGAGAAAAGAEGPGSPGVPGSPPEAASEPPTGLRFSPEQVACVC----EAL 98
           +G  A      AG  AA A       V GSPP +    P+ ++F P   A       ++ 
Sbjct: 13  QGRLAGWLAVRAGLLAAPAAVHSPAEVHGSPPASLCPRPS-VKFRPGLTAMALPTPSDST 71

Query: 99  LQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEY---AELYRLLESR--PFP 153
           L A   GR  R      P++        LRA     F+R  Y   A   RL ++   P P
Sbjct: 72  LPAEARGRGRRRRLVWTPSQ-----SEALRA----CFERNPYPGIATRERLAQAIGIPEP 122

Query: 154 AAHHAFLQDLYLRARYHEAERA-----RGRALGAVDKYRLRKKFPLPKTIWDGEETVYCF 208
                F  +   + R H  E       RG   G       R+K    +T   G +T    
Sbjct: 123 RVQIWFQNERSRQLRQHRRESRPWPGRRGPPEG-------RRK----RTAVTGSQT---- 167

Query: 209 KERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKS 268
                A L   +  +R+P    +  LA  TGL  +++  WF+NRR R   G GG AP ++
Sbjct: 168 -----ALLLRAFEKDRFPGIAAREELARETGLPESRIQIWFQNRRAR-HPGQGGRAPAQA 221

Query: 269 ESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAP-CPASSSILVNGSF 327
              G   +       P       AP     A  G+    GTG PAP  P +   L  G+F
Sbjct: 222 ---GGLCSAAPGGGHP-------APSWVAFAHTGA---WGTGLPAPHVPCAPGALPQGAF 268

Query: 328 LAASGSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLD 387
           ++ +   A      P +    A        P    G      P P P GA     +    
Sbjct: 269 VSQAARAA------PALQPSQAAPAEGVSQPAPARGDFAYAAPAP-PDGALSHPQAPRWP 321

Query: 388 PQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFP---LPPGP 444
           P  G+ R +             VA PGPA      GP  Q V  PPT+   P      GP
Sbjct: 322 PHPGKSREDRDPQRDGLPGPCAVAQPGPAQA----GPQGQGVLAPPTSQGSPWWGWGRGP 377

Query: 445 VPAVAA--PQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLP 488
             A AA  PQ     PP   P   S ++    +  +   SQ +  P
Sbjct: 378 QVAGAAWEPQAGAAPPPQPAPPDASASARQGQMQGIPAPSQALQEP 423


>gi|91982772 mucin 17 [Homo sapiens]
          Length = 4493

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 84/384 (21%), Positives = 148/384 (38%), Gaps = 43/384 (11%)

Query: 275  TTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSP 334
            TT  E++ SP   E  + P S  +         GT P    P S +++ N      S +P
Sbjct: 2252 TTSTEATSSPTTAEGTSIPTSTLSE--------GTTPLTSIPVSHTLVANSEVSTLSTTP 2303

Query: 335  AVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQPSPQGASE-----TKTSLVLDPQ 389
                +  P   +     EASS  P   T  G + P   S +G +        T++V   +
Sbjct: 2304 VD--SNTPFTTST----EASSPPP---TAEGTSMPTSTSSEGNTPLTRMPVSTTMVASFE 2354

Query: 390  TGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPAVA 449
            T  +    A +  P T  +Q A   P   ++   P +    G     + P+    +P V+
Sbjct: 2355 TSTLSTTPADTSTPVTTYSQ-AGSSPTTADDTSMPTSTYSEGSTPLTSVPV--STMPVVS 2411

Query: 450  APQVVPLSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAA 509
            +      + P    T ++ ++   + P     + + T P + G   L +    +   V++
Sbjct: 2412 SEASTHSTTPVDTSTPVTTSTEASSSPTTAEGTSIPTSPPSEGTTPLASMPVSTTPVVSS 2471

Query: 510  AAGPANVHLINSGVGVTA-------------LQLPSATAP-GNFLLAN-PVSGSPIVTGV 554
             AG  +   +++   +T              + +P +TA  G+ LL + PVS +P+ +  
Sbjct: 2472 EAGTLSTTPVDTSTPMTTSTEASSSPTTAEDIVVPISTASEGSTLLTSIPVSTTPVASPE 2531

Query: 555  AVQQGKIILTATFP--TSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSP-ALPEA 611
            A       + +  P  TS  +S     A G ++P    +  S P   +PV+  P A  EA
Sbjct: 2532 ASTLSTTPVDSNSPVVTSTEISSSATSAEGTSMPTSTYSEGSTPLRSMPVSTKPLASSEA 2591

Query: 612  HALGTLSAQQPPPAAATTSSTSLP 635
              L T       P   +T ++S P
Sbjct: 2592 STLSTTPVDTSIPVTTSTETSSSP 2615



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 88/400 (22%), Positives = 147/400 (36%), Gaps = 36/400 (9%)

Query: 268  SESDGNPTTEDESSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSF 327
            +E+  +PTT + +S         + P+++       +  +  G  +  P  +S  V  S 
Sbjct: 2786 TEASSSPTTAEVTSMPTSTPSETSTPLTSMPVNHTPVASSEAGTLSTTPVDTSTPVTTST 2845

Query: 328  LAASGSPAVLLNGGPVIINGLALG-EASSLGPLLLTGGGGAPPPQPSPQGASETKT--SL 384
             A+S          P    G+ +    +S G  LLT    + P   +P  +SE  T  + 
Sbjct: 2846 KASSS---------PTTAEGIVVPISTASEGSTLLT----SIPVSTTPVASSEASTLSTT 2892

Query: 385  VLDPQTGEVRLEEAQSEAPETKGAQVAAPGPALGEEVLGPLAQV-VPGPPTAATFPLPPG 443
             +D         E  S     +G  +    P+   EV  PL  + V   P A +      
Sbjct: 2893 PVDTSIPVTTSTEGSSSPTTAEGTSMPISTPS---EVSTPLTSILVSTVPVAGSEASTLS 2949

Query: 444  PVPAVAAPQVVPLSPPPGYPTGLSPTSPLLNLP----QVVPTSQVVTLPQAVGPLQLLAA 499
              P      V   +     PT    TS  ++ P      + +  V T+P A      L+ 
Sbjct: 2950 TTPVDTRTPVTTSAEASSSPTTAEGTSMPISTPGERRTPLTSMSVSTMPVASSEASTLSR 3009

Query: 500  GPG---SPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAV 556
             P    +PV  +  A  +      +G+ ++     S       L + PVS +P+    A 
Sbjct: 3010 TPADTSTPVTTSTEASSSPTTAEGTGIPISTPSEGSTP-----LTSIPVSTTPVAIPEAS 3064

Query: 557  QQGKIILTATFP--TSMLVSQVLPPAPGLALPLKPETAISVPEGGLPVAPSPALPEAHAL 614
                  + +  P  TS  VS    PA G ++P+   +  S P  G+PV+ +P    + A+
Sbjct: 3065 TLSTTPVDSNSPVVTSTEVSSSPTPAEGTSMPISTYSEGSTPLTGVPVSTTPV--TSSAI 3122

Query: 615  GTLSAQQPPPAAATTSSTSLPFSPDSPGLLPNFPAPPPEG 654
             TLS      +   T+ST    SP +        + P EG
Sbjct: 3123 STLSTTPVDTSTPVTTSTEAHSSPTTSEGTSMPTSTPSEG 3162



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 83/441 (18%), Positives = 152/441 (34%), Gaps = 43/441 (9%)

Query: 227  TPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPCKSESDGNPTTEDESSRSPED 286
            TP E+R   T   +S   V++   +   R            +E+  +PTT + +      
Sbjct: 2981 TPGERRTPLTSMSVSTMPVASSEASTLSRTPADTSTPVTTSTEASSSPTTAEGTGIPIST 3040

Query: 287  LERGAAPVSAEAAAQGSIFLAGTGPPAPCPA-SSSILVNGSFLAASGSPAVLLNGGPVII 345
               G+ P+++   +   + +      +  P  S+S +V  + +++S +PA    G  + I
Sbjct: 3041 PSEGSTPLTSIPVSTTPVAIPEASTLSTTPVDSNSPVVTSTEVSSSPTPA---EGTSMPI 3097

Query: 346  NGLALGEASSLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEAQSEAPET 405
            +  + G     G  + T         P    A  T ++  +D  T      EA S    +
Sbjct: 3098 STYSEGSTPLTGVPVST--------TPVTSSAISTLSTTPVDTSTPVTTSTEAHSSPTTS 3149

Query: 406  KGAQVAAPGPALGEEVLG--PLAQVVPGPPTAATFPLPPGPVPAVAAPQVVPLSPPPGYP 463
            +G  +    P+ G   L   P++ ++      +T    P              S      
Sbjct: 3150 EGTSMPTSTPSEGSTPLTYMPVSTMLVVSSEDSTLSATPVDTSTPVTTSTEATSSTTAEG 3209

Query: 464  TGLSPTSPLLNLPQV--VPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINS 521
            T +  ++P   +  +  VP S           L        +P+  +  A        +S
Sbjct: 3210 TSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEAS-------SS 3262

Query: 522  GVGVTALQLPSATAPGNFLLANPVSGSPI-VTGVAVQQGKIILTATFPTSMLV------S 574
                    +P++T       + P++  P+  T VA  +   + T    TS  V      S
Sbjct: 3263 PPTAEGTSMPTSTPSEG---STPLTSMPVSTTTVASSETSTLSTTPADTSTPVTTYSQAS 3319

Query: 575  QVLPPAPGLALPLKPETAISVPEGGLPVAPSPAL-PEAHALGTLSAQQPPPAAATTSS-- 631
               P A G ++P    +  S P   +  + +P +  EA  L T       P   +T +  
Sbjct: 3320 SSPPIADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPVDTSTPVTTSTEASL 3379

Query: 632  -------TSLPFSPDSPGLLP 645
                   TS+P S  S G  P
Sbjct: 3380 SPTTAEGTSIPTSSPSEGTTP 3400



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 85/440 (19%), Positives = 146/440 (33%), Gaps = 32/440 (7%)

Query: 222  GNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAGGGAPC--KSESDGNPTTEDE 279
            G   PT      +  LT + ++              T      P    +E+  +P T + 
Sbjct: 3209 GTSIPTSTPSEGMTPLTSVPVSNTPVASSEASILSTTPVDSNTPLTTSTEASSSPPTAEG 3268

Query: 280  SSRSPEDLERGAAPVSAEAAAQGSIFLAGTGPPAPCPASSSILVNGSFLAASGSPAVLLN 339
            +S        G+ P+++   +  ++  + T   +  PA +S  V  ++  AS SP     
Sbjct: 3269 TSMPTSTPSEGSTPLTSMPVSTTTVASSETSTLSTTPADTSTPVT-TYSQASSSPP---- 3323

Query: 340  GGPVIINGLALGEAS-SLGPLLLTGGGGAPPPQPSPQGASETKTSLVLDPQTGEVRLEEA 398
                I +G ++  ++ S G   LT    +  P  S + ++ + T +  D  T      EA
Sbjct: 3324 ----IADGTSMPTSTYSEGSTPLTNMSFSTTPVVSSEASTLSTTPV--DTSTPVTTSTEA 3377

Query: 399  QSEAPETKGAQVAAPGPALGEEVLGPLAQVVPGPPTAATFPLPPGPVPA---VAAPQVVP 455
                   +G  +    P+ G   L  +        ++    L   PV +   V       
Sbjct: 3378 SLSPTTAEGTSIPTSSPSEGTTPLASMPVSTTPVVSSEVNTLSTTPVDSNTLVTTSTEAS 3437

Query: 456  LSPPPGYPTGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPAN 515
             SP     T L PTS        +    + T P A      L+  P         + P N
Sbjct: 3438 SSPTIAEGTSL-PTSTTSEGSTPLSIMPLSTTPVASSEASTLSTTPVDTSTPVTTSSPTN 3496

Query: 516  ----------VHLINSGVGVTAL-QLPSATAPGNFLLANPVSGSPIVTGVAVQQGKIILT 564
                      +    +G G T L  +P +T P     A+ +S +P+ +   V       +
Sbjct: 3497 SSPTTAEVTSMPTSTAGEGSTPLTNMPVSTTPVASSEASTLSTTPVDSNTFVTSSSQASS 3556

Query: 565  ATFPTSMLVSQVLPPAPG---LALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQ 621
            +     +   ++  P+ G   L   L   T ++  E   P  PS          T S   
Sbjct: 3557 SPATLQVTTMRMSTPSEGSSSLTTMLLSSTYVTSSEASTPSTPSVDRSTPVTTSTQSNST 3616

Query: 622  PPPAAATTSSTSLPFSPDSP 641
            P P    T   S P    +P
Sbjct: 3617 PTPPEVITLPMSTPSEVSTP 3636


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.131    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,193,600
Number of Sequences: 37866
Number of extensions: 2551341
Number of successful extensions: 31075
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 495
Number of HSP's successfully gapped in prelim test: 1517
Number of HSP's that attempted gapping in prelim test: 16603
Number of HSP's gapped (non-prelim): 11906
length of query: 739
length of database: 18,247,518
effective HSP length: 110
effective length of query: 629
effective length of database: 14,082,258
effective search space: 8857740282
effective search space used: 8857740282
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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