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Search of human proteins with 40255197
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
(466 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40255197 RasGEF domain family, member 1C [Homo sapiens] 946 0.0
gi|22749129 RasGEF domain family, member 1B [Homo sapiens] 626 e-179
gi|117168263 RasGEF domain family, member 1A [Homo sapiens] 491 e-139
gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens] 101 1e-21
gi|54633319 PDZ domain-containing guanine nucleotide exchange fa... 94 2e-19
gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 91 2e-18
gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 91 2e-18
gi|224586880 Ras protein-specific guanine nucleotide-releasing f... 91 3e-18
gi|24797099 Ras protein-specific guanine nucleotide-releasing fa... 91 3e-18
gi|24797101 Ras protein-specific guanine nucleotide-releasing fa... 91 3e-18
gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 87 4e-17
gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 87 4e-17
gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 87 4e-17
gi|38505170 Ras protein-specific guanine nucleotide-releasing fa... 87 4e-17
gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo sapi... 83 6e-16
gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo sapi... 83 6e-16
gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Hom... 81 2e-15
gi|4758532 ral guanine nucleotide dissociation stimulator-like 2... 81 2e-15
gi|15529996 son of sevenless homolog 1 [Homo sapiens] 80 4e-15
gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1 [... 80 5e-15
gi|93102367 ral guanine nucleotide dissociation stimulator-like ... 78 1e-14
gi|7662334 RAS guanyl releasing protein 3 (calcium and DAG-regul... 76 6e-14
gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens] 76 7e-14
gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo sapi... 76 7e-14
gi|213385270 RAS guanyl releasing protein 3 (calcium and DAG-reg... 76 7e-14
gi|24762239 RAS guanyl releasing protein 3 (calcium and DAG-regu... 76 7e-14
gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo ... 73 6e-13
gi|154689780 son of sevenless homolog 2 [Homo sapiens] 72 1e-12
gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Hom... 72 1e-12
gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Hom... 72 1e-12
>gi|40255197 RasGEF domain family, member 1C [Homo sapiens]
Length = 466
Score = 946 bits (2445), Expect = 0.0
Identities = 466/466 (100%), Positives = 466/466 (100%)
Query: 1 MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEK 60
MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEK
Sbjct: 1 MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEK 60
Query: 61 AYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTET 120
AYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTET
Sbjct: 61 AYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTET 120
Query: 121 FPRDFQEESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPI 180
FPRDFQEESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPI
Sbjct: 121 FPRDFQEESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPI 180
Query: 181 SYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPC 240
SYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPC
Sbjct: 181 SYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPC 240
Query: 241 FSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMA 300
FSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMA
Sbjct: 241 FSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMA 300
Query: 301 IISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSRE 360
IISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSRE
Sbjct: 301 IISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSRE 360
Query: 361 KIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDAS 420
KIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDAS
Sbjct: 361 KIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDAS 420
Query: 421 ITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSILGKT 466
ITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSILGKT
Sbjct: 421 ITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSILGKT 466
>gi|22749129 RasGEF domain family, member 1B [Homo sapiens]
Length = 473
Score = 626 bits (1615), Expect = e-179
Identities = 321/473 (67%), Positives = 368/473 (77%), Gaps = 9/473 (1%)
Query: 1 MPQTLSASDMVTPGSLSPPPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYYPEK 60
MPQT S M + + + G D S SLE LIQHLVP DYYP++
Sbjct: 1 MPQTPPFSAMFDSSGYNRNLYQSAEDSCGGLYYHDNNLLSGSLEALIQHLVPNVDYYPDR 60
Query: 61 AYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTET 120
YIFTFLLSSRLF+ P EL+A+VCHLC+E Q+L P DK ++RK PK+LQLL EWTET
Sbjct: 61 TYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAPKILQLLTEWTET 120
Query: 121 FPRDFQEESTIGHLKDVVGRIAPCDE-AYRKRMHQLLQALHQKLAALRQGPEGLV----- 174
FP DF++E + +LKD+ RIA +E YRK + Q++Q L +KLAAL Q E L
Sbjct: 121 FPYDFRDERMMRNLKDLAHRIASGEEQTYRKNVQQMMQCLIRKLAALSQYEEVLAKISST 180
Query: 175 GADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPL 234
D+ +TKP SI R+++ VC+DPYTLAQQLTH+ELERL +IGPEEFVQAFV KDPL
Sbjct: 181 STDRLTVLKTKPQ-SIQRDIITVCNDPYTLAQQLTHIELERLNYIGPEEFVQAFVQKDPL 239
Query: 235 ASTKPCFSD--KTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNI 292
+ K C+S+ KT NLEAYV+WFNRL YLVATEICMP KKK RA++IE+FIDVARECFNI
Sbjct: 240 DNDKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEYFIDVARECFNI 299
Query: 293 GNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRS 352
GNFNSLMAIISGMNMSPVSRLKKTWAKV+TAKF ILEHQMDP+ NF NYRTALRGAA RS
Sbjct: 300 GNFNSLMAIISGMNMSPVSRLKKTWAKVKTAKFDILEHQMDPSSNFYNYRTALRGAAQRS 359
Query: 353 LTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVE 412
LTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKF ELAKQV EF+TWKQVE
Sbjct: 360 LTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVE 419
Query: 413 CPFEQDASITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSILGK 465
CPFE+D I YL T P+FSED LYLASYESE PEN EK+RWK+LRSS+LG+
Sbjct: 420 CPFERDRKILQYLLTVPVFSEDALYLASYESEGPENHIEKDRWKSLRSSLLGR 472
>gi|117168263 RasGEF domain family, member 1A [Homo sapiens]
Length = 481
Score = 491 bits (1263), Expect = e-139
Identities = 259/482 (53%), Positives = 337/482 (69%), Gaps = 19/482 (3%)
Query: 1 MPQT-LSASDMVTP---GSLSPPPTEPTDGEQAGQPLL---DGAPSSASLETLIQHLVPT 53
MPQT + S ++ P G + P E G G L DG S SLE L++HLVPT
Sbjct: 1 MPQTSVVFSSILGPSCSGQVQPGMGERGGGAGGGSGDLIFQDGHLISGSLEALMEHLVPT 60
Query: 54 ADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQL 113
DYYP++ YIFTFLLSSR+F+ P +LLARV +C+EQ+Q + +KA+++ F K++QL
Sbjct: 61 VDYYPDRTYIFTFLLSSRVFMPPHDLLARVGQICVEQKQQLEAGPEKAKLKSFSAKIVQL 120
Query: 114 LAEWTETFPRDFQEESTIGHLKDVVGRIAPCDE---AYRKRMHQLLQALHQKLAALRQGP 170
L EWTE FP DFQ+E + LK + R+ CDE +K + Q+ Q+L LAA Q
Sbjct: 121 LKEWTEAFPYDFQDEKAMAELKAITHRVTQCDEENGTVKKAIAQMTQSLLLSLAARSQLQ 180
Query: 171 E-----GLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFV 225
E DK +TKPPA+ +++LGVC DP LAQQLTH+EL+R+ I PE+ +
Sbjct: 181 ELREKLRPPAVDKGPILKTKPPAA-QKDILGVCCDPLVLAQQLTHIELDRVSSIYPEDLM 239
Query: 226 QAFVNKDPLASTKPCFSD--KTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFI 283
Q + D L + + C D KT +LEAY WFN L LVATE+C KKK R +++EFFI
Sbjct: 240 QIVSHMDSLDNHR-CRGDLTKTYSLEAYDNWFNCLSMLVATEVCRVVKKKHRTRMLEFFI 298
Query: 284 DVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFILEHQMDPTGNFCNYRT 343
DVARECFNIGNFNS+MAIISGMN+SPV+RLKKTW+KV+TAKF +LEH MDP+ NFCNYRT
Sbjct: 299 DVARECFNIGNFNSMMAIISGMNLSPVARLKKTWSKVKTAKFDVLEHHMDPSSNFCNYRT 358
Query: 344 ALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVG 403
AL+GA RS A+SSREKIVIP F+L +KDIYFL++ N LPNGH+NF+KF E+++Q+
Sbjct: 359 ALQGATQRSQMANSSREKIVIPVFNLFVKDIYFLHKIHTNHLPNGHINFKKFWEISRQIH 418
Query: 404 EFITWKQVECPFEQDASITHYLYTAPIFSEDGLYLASYESESPENQTEKERWKALRSSIL 463
EF+TW QVECPFE+D I YL TAPI+SE+ L++AS+ESE PEN EK+ WK LR+++L
Sbjct: 419 EFMTWTQVECPFEKDKKIQSYLLTAPIYSEEALFVASFESEGPENHMEKDSWKTLRTTLL 478
Query: 464 GK 465
+
Sbjct: 479 NR 480
>gi|7657261 Rap guanine nucleotide exchange factor 2 [Homo sapiens]
Length = 1499
Score = 101 bits (252), Expect = 1e-21
Identities = 67/202 (33%), Positives = 109/202 (53%), Gaps = 21/202 (10%)
Query: 204 LAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVA 263
+A QL+ E R+I P E++ L S C +NL+ + + N+ + VA
Sbjct: 721 VATQLSMRNFELFRNIEPTEYIDDLFK---LRSKTSC-----ANLKRFEEVINQETFWVA 772
Query: 264 TEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--R 321
+EI + +R ++I+ FI +A C NFNS+ AIISG+N++PV+RL+ TW K+ +
Sbjct: 773 SEILRETNQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLAPVARLRTTWEKLPNK 832
Query: 322 TAKFF-ILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEG 380
K F L+ DP+ N YR L + + +IP F ++ KD+ FL+EG
Sbjct: 833 YEKLFQDLQDLFDPSRNMAKYRNVLNS---------QNLQPPIIPLFPVIKKDLTFLHEG 883
Query: 381 CANRLPNGHVNFEKFLELAKQV 402
+++ +G VNFEK +AK++
Sbjct: 884 NDSKV-DGLVNFEKLRMIAKEI 904
>gi|54633319 PDZ domain-containing guanine nucleotide exchange factor
I [Homo sapiens]
Length = 1601
Score = 94.4 bits (233), Expect = 2e-19
Identities = 74/265 (27%), Positives = 127/265 (47%), Gaps = 37/265 (13%)
Query: 204 LAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSN--LEAYVKWFNRLCYL 261
+A QL+ + + R+I P E++ + KT N L+ + N+ +
Sbjct: 864 VATQLSMRDFDLFRNIEPTEYIDDLFK----------LNSKTGNTHLKRFEDIVNQETFW 913
Query: 262 VATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVR 321
VA+EI A + +R ++I+ FI +A C NFNS+ AIISG+N++ V+RL+ TW K+
Sbjct: 914 VASEILTEANQLKRMKIIKHFIKIALHCRECKNFNSMFAIISGLNLASVARLRGTWEKLP 973
Query: 322 T---AKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLN 378
+ L+ DP+ N YR L + S + +IP F ++ KD+ FL+
Sbjct: 974 SKYEKHLQDLQDIFDPSRNMAKYRNIL---------SSQSMQPPIIPLFPVVKKDMTFLH 1024
Query: 379 EGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTAPIFSEDGLYL 438
EG +++ +G VNFEK ++K++ + + + A +F + L
Sbjct: 1025 EGNDSKV-DGLVNFEKLRMISKEIRQVVRMTSAN------------MDPAMMFRQRSLSQ 1071
Query: 439 ASYESESPENQTEKERWKALRSSIL 463
S S + Q + +A RSS+L
Sbjct: 1072 GSTNSNMLDVQGGAHKKRARRSSLL 1096
>gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform
b [Homo sapiens]
Length = 867
Score = 90.9 bits (224), Expect = 2e-18
Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 17/183 (9%)
Query: 241 FSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMA 300
F T+NL+ +++ FN + + V TEIC+ ++ +R Q+++ FI +A C N NS A
Sbjct: 662 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 721
Query: 301 IISGMNMSPVSRLKKTWAKV--RTAKFFI-LEHQMDPTGNFCNYRTALRGAAHRSLTAHS 357
I+ G++ VSRL TW K+ + KF+ E MDP+ N YR + +
Sbjct: 722 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTV-----------A 770
Query: 358 SREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQ 417
E +IPF LLIKD+ F +EG + N VNFEK +A ++ PF
Sbjct: 771 KLEPPLIPFMPLLIKDMTFTHEGNKTFIDN-LVNFEKMRMIANTARTVRYYRSQ--PFNP 827
Query: 418 DAS 420
DA+
Sbjct: 828 DAA 830
>gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform
a [Homo sapiens]
Length = 1011
Score = 90.9 bits (224), Expect = 2e-18
Identities = 62/183 (33%), Positives = 94/183 (51%), Gaps = 17/183 (9%)
Query: 241 FSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMA 300
F T+NL+ +++ FN + + V TEIC+ ++ +R Q+++ FI +A C N NS A
Sbjct: 806 FKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKRVQLLKKFIKIAAHCKEYKNLNSFFA 865
Query: 301 IISGMNMSPVSRLKKTWAKV--RTAKFFI-LEHQMDPTGNFCNYRTALRGAAHRSLTAHS 357
I+ G++ VSRL TW K+ + KF+ E MDP+ N YR + +
Sbjct: 866 IVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLMDPSRNHRAYRLTV-----------A 914
Query: 358 SREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQ 417
E +IPF LLIKD+ F +EG + N VNFEK +A ++ PF
Sbjct: 915 KLEPPLIPFMPLLIKDMTFTHEGNKTFIDN-LVNFEKMRMIANTARTVRYYRSQ--PFNP 971
Query: 418 DAS 420
DA+
Sbjct: 972 DAA 974
>gi|224586880 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 3 [Homo sapiens]
Length = 1257
Score = 90.5 bits (223), Expect = 3e-18
Identities = 73/260 (28%), Positives = 120/260 (46%), Gaps = 30/260 (11%)
Query: 196 GVCSDPYT------LAQQLTHVELERLRHIGPEEFV-QAFVNKDPLASTKPCFSDKTSNL 248
GV ++P+ +A+QLT ++ + I EEF Q ++ + +++T +
Sbjct: 1012 GVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK--------NERTPYI 1063
Query: 249 EAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMS 308
K FN + L+A+EI R IE ++ VA C + N+N+++ I S MN S
Sbjct: 1064 MKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRS 1123
Query: 309 PVSRLKKTWAKV-RTAKFFI--LEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIP 365
+ RLKKTW KV + K I L+ + G F N R AL+ + +P
Sbjct: 1124 AIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVP 1172
Query: 366 FFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYL 425
+ + + D+ F+ EG N +G VNF K ++ + E ++Q E A +T YL
Sbjct: 1173 YLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1232
Query: 426 YTAP-IFSEDGLYLASYESE 444
+ E+ LY +S E
Sbjct: 1233 LDQSFVMDEESLYESSLRIE 1252
>gi|24797099 Ras protein-specific guanine nucleotide-releasing factor
1 isoform 1 [Homo sapiens]
Length = 1273
Score = 90.5 bits (223), Expect = 3e-18
Identities = 73/260 (28%), Positives = 120/260 (46%), Gaps = 30/260 (11%)
Query: 196 GVCSDPYT------LAQQLTHVELERLRHIGPEEFV-QAFVNKDPLASTKPCFSDKTSNL 248
GV ++P+ +A+QLT ++ + I EEF Q ++ + +++T +
Sbjct: 1028 GVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK--------NERTPYI 1079
Query: 249 EAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMS 308
K FN + L+A+EI R IE ++ VA C + N+N+++ I S MN S
Sbjct: 1080 MKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRS 1139
Query: 309 PVSRLKKTWAKV-RTAKFFI--LEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIP 365
+ RLKKTW KV + K I L+ + G F N R AL+ + +P
Sbjct: 1140 AIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVP 1188
Query: 366 FFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYL 425
+ + + D+ F+ EG N +G VNF K ++ + E ++Q E A +T YL
Sbjct: 1189 YLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 1248
Query: 426 YTAP-IFSEDGLYLASYESE 444
+ E+ LY +S E
Sbjct: 1249 LDQSFVMDEESLYESSLRIE 1268
>gi|24797101 Ras protein-specific guanine nucleotide-releasing
factor 1 isoform 2 [Homo sapiens]
Length = 489
Score = 90.5 bits (223), Expect = 3e-18
Identities = 73/260 (28%), Positives = 120/260 (46%), Gaps = 30/260 (11%)
Query: 196 GVCSDPYT------LAQQLTHVELERLRHIGPEEFV-QAFVNKDPLASTKPCFSDKTSNL 248
GV ++P+ +A+QLT ++ + I EEF Q ++ + +++T +
Sbjct: 244 GVKAEPFENHSALEIAEQLTLLDHLVFKKIPYEEFFGQGWMKLEK--------NERTPYI 295
Query: 249 EAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMS 308
K FN + L+A+EI R IE ++ VA C + N+N+++ I S MN S
Sbjct: 296 MKTTKHFNDISNLIASEIIRNEDINARVSAIEKWVAVADICRCLHNYNAVLEITSSMNRS 355
Query: 309 PVSRLKKTWAKV-RTAKFFI--LEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIP 365
+ RLKKTW KV + K I L+ + G F N R AL+ + +P
Sbjct: 356 AIFRLKKTWLKVSKQTKALIDKLQKLVSSEGRFKNLREALKNC-----------DPPCVP 404
Query: 366 FFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYL 425
+ + + D+ F+ EG N +G VNF K ++ + E ++Q E A +T YL
Sbjct: 405 YLGMYLTDLAFIEEGTPNYTEDGLVNFSKMRMISHIIREIRQFQQTAYKIEHQAKVTQYL 464
Query: 426 YTAP-IFSEDGLYLASYESE 444
+ E+ LY +S E
Sbjct: 465 LDQSFVMDEESLYESSLRIE 484
>gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 86.7 bits (213), Expect = 4e-17
Identities = 57/159 (35%), Positives = 86/159 (54%), Gaps = 15/159 (9%)
Query: 245 TSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISG 304
T+NLE +++ FN L Y VATE+C+ RAQ++ FI +A N NS A++ G
Sbjct: 659 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 718
Query: 305 MNMSPVSRLKKTWAKV--RTAKFF-ILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREK 361
++ S +SRL TW ++ + K + LE +DP+ N YR AL +
Sbjct: 719 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 767
Query: 362 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAK 400
VIPF LL+KD+ F++EG + L +NFEK +A+
Sbjct: 768 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 805
Score = 32.7 bits (73), Expect = 0.72
Identities = 33/133 (24%), Positives = 62/133 (46%), Gaps = 19/133 (14%)
Query: 19 PPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYY-PEKAYIFTFLLSSRLFIEPR 77
P PT G ++ G P LE L++ + P + + P + ++ FLL+ R+F+
Sbjct: 333 PSRPPTPGRNR-YTVMSGTPEKI-LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSA 390
Query: 78 ELLARVC-HLCIE-----QQQLDKPVLDKARVRKFGPKLLQLLAEWTETF----PRDFQE 127
+L A + H +E +Q+ V +K + ++L+L+++W + D
Sbjct: 391 QLCAALLHHFHVEPAGGSEQERSTYVCNKRQ------QILRLVSQWVALYGSMLHTDPVA 444
Query: 128 ESTIGHLKDVVGR 140
S + L D+VGR
Sbjct: 445 TSFLQKLSDLVGR 457
>gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b
[Homo sapiens]
Length = 881
Score = 86.7 bits (213), Expect = 4e-17
Identities = 57/159 (35%), Positives = 86/159 (54%), Gaps = 15/159 (9%)
Query: 245 TSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISG 304
T+NLE +++ FN L Y VATE+C+ RAQ++ FI +A N NS A++ G
Sbjct: 659 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 718
Query: 305 MNMSPVSRLKKTWAKV--RTAKFF-ILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREK 361
++ S +SRL TW ++ + K + LE +DP+ N YR AL +
Sbjct: 719 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 767
Query: 362 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAK 400
VIPF LL+KD+ F++EG + L +NFEK +A+
Sbjct: 768 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 805
Score = 32.7 bits (73), Expect = 0.72
Identities = 33/133 (24%), Positives = 62/133 (46%), Gaps = 19/133 (14%)
Query: 19 PPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYY-PEKAYIFTFLLSSRLFIEPR 77
P PT G ++ G P LE L++ + P + + P + ++ FLL+ R+F+
Sbjct: 333 PSRPPTPGRNR-YTVMSGTPEKI-LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSA 390
Query: 78 ELLARVC-HLCIE-----QQQLDKPVLDKARVRKFGPKLLQLLAEWTETF----PRDFQE 127
+L A + H +E +Q+ V +K + ++L+L+++W + D
Sbjct: 391 QLCAALLHHFHVEPAGGSEQERSTYVCNKRQ------QILRLVSQWVALYGSMLHTDPVA 444
Query: 128 ESTIGHLKDVVGR 140
S + L D+VGR
Sbjct: 445 TSFLQKLSDLVGR 457
>gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a
[Homo sapiens]
Length = 923
Score = 86.7 bits (213), Expect = 4e-17
Identities = 57/159 (35%), Positives = 86/159 (54%), Gaps = 15/159 (9%)
Query: 245 TSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISG 304
T+NLE +++ FN L Y VATE+C+ RAQ++ FI +A N NS A++ G
Sbjct: 701 TANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFG 760
Query: 305 MNMSPVSRLKKTWAKV--RTAKFF-ILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREK 361
++ S +SRL TW ++ + K + LE +DP+ N YR AL +
Sbjct: 761 LSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLAL-----------AKLSP 809
Query: 362 IVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAK 400
VIPF LL+KD+ F++EG + L +NFEK +A+
Sbjct: 810 PVIPFMPLLLKDMTFIHEG-NHTLVENLINFEKMRMMAR 847
Score = 32.7 bits (73), Expect = 0.72
Identities = 33/133 (24%), Positives = 62/133 (46%), Gaps = 19/133 (14%)
Query: 19 PPTEPTDGEQAGQPLLDGAPSSASLETLIQHLVPTADYY-PEKAYIFTFLLSSRLFIEPR 77
P PT G ++ G P LE L++ + P + + P + ++ FLL+ R+F+
Sbjct: 375 PSRPPTPGRNR-YTVMSGTPEKI-LELLLEAMGPDSSAHDPTETFLSDFLLTHRVFMPSA 432
Query: 78 ELLARVC-HLCIE-----QQQLDKPVLDKARVRKFGPKLLQLLAEWTETF----PRDFQE 127
+L A + H +E +Q+ V +K + ++L+L+++W + D
Sbjct: 433 QLCAALLHHFHVEPAGGSEQERSTYVCNKRQ------QILRLVSQWVALYGSMLHTDPVA 486
Query: 128 ESTIGHLKDVVGR 140
S + L D+VGR
Sbjct: 487 TSFLQKLSDLVGR 499
>gi|38505170 Ras protein-specific guanine nucleotide-releasing factor
2 [Homo sapiens]
Length = 1237
Score = 86.7 bits (213), Expect = 4e-17
Identities = 70/246 (28%), Positives = 110/246 (44%), Gaps = 24/246 (9%)
Query: 204 LAQQLTHVELERLRHIGPEEFV-QAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLV 262
LA+Q+T ++ R I EEF+ Q ++ D +++T + + FN + LV
Sbjct: 1006 LAEQITLLDHVIFRSIPYEEFLGQGWMKLDK--------NERTPYIMKTSQHFNDMSNLV 1057
Query: 263 ATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV-- 320
A++I A RA IE ++ VA C + N+N ++ I S +N S + RLKKTWAKV
Sbjct: 1058 ASQIMNYADVSSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAKVSK 1117
Query: 321 -RTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNE 379
A L+ + G F N R L+ +P+ + + D+ F+ E
Sbjct: 1118 QTKALMDKLQKTVSSEGRFKNLRETLKNC-----------NPPAVPYLGMYLTDLAFIEE 1166
Query: 380 GCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTAP-IFSEDGLYL 438
G N G VNF K ++ + E ++Q + + YL I ED LY
Sbjct: 1167 GTPNFTEEGLVNFSKMRMISHIIREIRQFQQTSYRIDHQPKVAQYLLDKDLIIDEDTLYE 1226
Query: 439 ASYESE 444
S + E
Sbjct: 1227 LSLKIE 1232
>gi|190684646 RAS guanyl releasing protein 1 isoform b [Homo
sapiens]
Length = 762
Score = 82.8 bits (203), Expect = 6e-16
Identities = 68/254 (26%), Positives = 113/254 (44%), Gaps = 26/254 (10%)
Query: 200 DPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLC 259
+P L++ LT++E + R I ++ VN C + + +E + N +
Sbjct: 205 EPEELSEHLTYLEFKSFRRISFSDYQNYLVNS--------CVKENPT-MERSIALCNGIS 255
Query: 260 YLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAK 319
V + + RA+V FI VA++ + NFN+LMA+I G+ S +SRLK+T +
Sbjct: 256 QWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSH 315
Query: 320 VRTAKFFILEHQ---MDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYF 376
V +L + + N+ NYR A+ IP + +KD+
Sbjct: 316 VPHEINKVLGEMTELLSSSRNYDNYR-----------RAYGECTDFKIPILGVHLKDLIS 364
Query: 377 LNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTA--PIFSED 434
L E + L +G VN K L L + E + ++V P E + + H L + ++ED
Sbjct: 365 LYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTED 424
Query: 435 GLYLASYESESPEN 448
+Y SY E P N
Sbjct: 425 EIYELSYARE-PRN 437
>gi|190684644 RAS guanyl releasing protein 1 isoform a [Homo
sapiens]
Length = 797
Score = 82.8 bits (203), Expect = 6e-16
Identities = 68/254 (26%), Positives = 113/254 (44%), Gaps = 26/254 (10%)
Query: 200 DPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLC 259
+P L++ LT++E + R I ++ VN C + + +E + N +
Sbjct: 205 EPEELSEHLTYLEFKSFRRISFSDYQNYLVNS--------CVKENPT-MERSIALCNGIS 255
Query: 260 YLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAK 319
V + + RA+V FI VA++ + NFN+LMA+I G+ S +SRLK+T +
Sbjct: 256 QWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSH 315
Query: 320 VRTAKFFILEHQ---MDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYF 376
V +L + + N+ NYR A+ IP + +KD+
Sbjct: 316 VPHEINKVLGEMTELLSSSRNYDNYR-----------RAYGECTDFKIPILGVHLKDLIS 364
Query: 377 LNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTA--PIFSED 434
L E + L +G VN K L L + E + ++V P E + + H L + ++ED
Sbjct: 365 LYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLYYTED 424
Query: 435 GLYLASYESESPEN 448
+Y SY E P N
Sbjct: 425 EIYELSYARE-PRN 437
>gi|119392077 Rap guanine nucleotide exchange factor (GEF) 5 [Homo
sapiens]
Length = 730
Score = 81.3 bits (199), Expect = 2e-15
Identities = 58/163 (35%), Positives = 85/163 (52%), Gaps = 15/163 (9%)
Query: 243 DKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAII 302
+ T+NL ++ N + VATEI + ++ +R Q+++ FI +A C N NS AI+
Sbjct: 531 EHTANLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQRNLNSFFAIV 590
Query: 303 SGMNMSPVSRLKKTWAKV--RTAKFFI-LEHQMDPTGNFCNYRTALRGAAHRSLTAHSSR 359
G+N + VSRL +TW K+ + K F LE DP+ N YR A +
Sbjct: 591 MGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFK-----------KM 639
Query: 360 EKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQV 402
+ IPF LL+KD+ F++EG L N VNFEK +A V
Sbjct: 640 KPPKIPFMPLLLKDVTFIHEGNKTFLDN-LVNFEKLHMIADTV 681
>gi|4758532 ral guanine nucleotide dissociation stimulator-like 2
[Homo sapiens]
Length = 777
Score = 80.9 bits (198), Expect = 2e-15
Identities = 89/385 (23%), Positives = 160/385 (41%), Gaps = 49/385 (12%)
Query: 40 SASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLCIEQQQLDKPVLD 99
+ +LE L++HL+ T + +++ FL + R F LL + + L+ D
Sbjct: 94 AGTLEALVRHLLDTRTSGTDVSFMSAFLATHRAFTSTPALLGLMAD---RLEALESHPTD 150
Query: 100 KARVRKFGPKLLQLLAEWTETFPRDFQEESTIGHLKDVVGRIAPCDEAYRKRMH----QL 155
+ + + + +L+ W + P DF E+ G L + + A K + L
Sbjct: 151 E--LERTTEVAISVLSTWLASHPEDFGSEAK-GQLDRLESFLLQTGYAAGKGVGGGSADL 207
Query: 156 LQALHQKLAALRQGPEGLVGADKPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELER 215
++ L ++ Q P+ KP++ PPA L+ + LA+QLT ++ E
Sbjct: 208 IRNLRSRVDP--QAPD----LPKPLALPGDPPADPTDVLVFLADH---LAEQLTLLDAEL 258
Query: 216 LRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVATEIC-------- 267
++ P + + +P S ++ A V FN++ V + +
Sbjct: 259 FLNLIPSQCLGGLWGH----RDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEG 314
Query: 268 ------MPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVR 321
P + QRA+++E +I VA EC + NF+S+ A++S + SP+ RL+ W +
Sbjct: 315 PGEVTIRPLRPPQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEAT 374
Query: 322 TAK---FFILEHQMDPTGNFCNYRTAL--RGAAHRSLTAHS-------SREKIVIPFFSL 369
F L N+ R L L HS SR V+P+
Sbjct: 375 RDSLRVFSSLCQIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGT 434
Query: 370 LIKDIYFLNEGCANRLPNGHVNFEK 394
+KD+ L+ + L NG++NF+K
Sbjct: 435 FLKDLVMLDAASKDELENGYINFDK 459
>gi|15529996 son of sevenless homolog 1 [Homo sapiens]
Length = 1333
Score = 80.1 bits (196), Expect = 4e-15
Identities = 94/413 (22%), Positives = 174/413 (42%), Gaps = 73/413 (17%)
Query: 28 QAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLC 87
+AG P++ +E L H+ Y + ++ TFL + R F +P+ELL+ L
Sbjct: 595 KAGIPIIKAGTVIKLIERLTYHM------YADPNFVRTFLTTYRSFCKPQELLS----LI 644
Query: 88 IEQQQLDKPVLDKA-----------------RVRK-----FGPKLLQLLAEWTETFPRDF 125
IE+ ++ +P +A R RK ++L + W E DF
Sbjct: 645 IERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDF 704
Query: 126 QEES-TIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISYRT 184
+ ++ + +++ +G + +A +K + + + + +K A GP I++++
Sbjct: 705 ERDAYLLQRMEEFIGTVR--GKAMKKWVESITKIIQRKKIARDNGP------GHNITFQS 756
Query: 185 KPPASI-------HRELLGVCS-DPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLAS 236
PP H E + + P +A+QLT +E + R + P E V + K+
Sbjct: 757 SPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEI 816
Query: 237 TKPCFSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFN 296
P + WF + +V TE ++R V+ I++ + + NFN
Sbjct: 817 NSPNLLKMIRHTTNLTLWFEKC--IVETE-----NLEERVAVVSRIIEILQVFQELNNFN 869
Query: 297 SLMAIISGMNMSPVSRLKKTWAKVRTAKFFILE--HQMDPTGNFCNYRTALRGAAHRSLT 354
++ ++S MN SPV RL T+ ++ + + ILE H++ ++ Y LR
Sbjct: 870 GVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELS-EDHYKKYLAKLR-------- 920
Query: 355 AHSSREKIVIPFFSLLIKDIYFLNEG---CANRLPNGHVNFEKFLELAKQVGE 404
S +PFF + + +I EG R +NF K ++A+ GE
Sbjct: 921 ---SINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGE 970
>gi|7705939 Rap guanine nucleotide exchange factor (GEF)-like 1
[Homo sapiens]
Length = 456
Score = 79.7 bits (195), Expect = 5e-15
Identities = 66/228 (28%), Positives = 110/228 (48%), Gaps = 24/228 (10%)
Query: 200 DPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLC 259
+P +A LT E R + EFV + + +T+NLE ++ + +
Sbjct: 218 EPEDVANHLTAFHWELFRCVHELEFVDYVFHGERGRR-------ETANLELLLQRCSEVT 270
Query: 260 YLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAK 319
+ VATE+ + +RAQ+++ FI +A C + S A++ G++ + VSRL+ TW K
Sbjct: 271 HWVATEVLLCEAPGKRAQLLKKFIKIAALCKQNQDLLSFYAVVMGLDNAAVSRLRLTWEK 330
Query: 320 VRTAKFFIL----EHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIY 375
+ KF L E+ DP N +YR + S + VIPF L++KD+
Sbjct: 331 L-PGKFKNLFRKFENLTDPCRNHKSYREVI-----------SKMKPPVIPFVPLILKDLT 378
Query: 376 FLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITH 423
FL+EG + L +G VN EK +A++V ++ + +AS H
Sbjct: 379 FLHEG-SKTLVDGLVNIEKLHSVAEKVRTIRKYRSRPLCLDMEASPNH 425
>gi|93102367 ral guanine nucleotide dissociation stimulator-like 1
[Homo sapiens]
Length = 803
Score = 78.2 bits (191), Expect = 1e-14
Identities = 87/389 (22%), Positives = 157/389 (40%), Gaps = 46/389 (11%)
Query: 40 SASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRE----LLARVCHLCIEQQQLDK 95
+ +LE L+++L+ TA + YI FL + R F +E LL R +L + D
Sbjct: 106 AGTLEKLVENLL-TAFGDNDFTYISIFLSTYRGFASTKEVLELLLDRYGNLTSPNCEEDG 164
Query: 96 PVLDKARVRKFGPKLLQLLAEWTETFPRDFQEES---TIGHLKDVVGRIAPCDEAYRKRM 152
+ +L W + DF+E + L D + R+ P + R+
Sbjct: 165 SQSSSESKMVIRNAIASILRAWLDQCAEDFREPPHFPCLQKLLDYLTRMMPGSDPERRAQ 224
Query: 153 HQLLQALHQKLAALRQGPEGLVGADKPISYRTKPPASIH--RELLGVCSDPYTLAQQLTH 210
+ L Q Q++ E G IS+ + + C +A+QLT+
Sbjct: 225 NLLEQFQKQEV-------ETDNGLPNTISFSLEEEEELEGGESAEFTCFSEDLVAEQLTY 277
Query: 211 VELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVATEIC--M 268
++ + + + P + ++ K + A + FN L V + I
Sbjct: 278 MDAQLFKKVVPHHCLGCIWSRRDKKENKHL----APTIRATISQFNTLTKCVVSTILGGK 333
Query: 269 PAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVRTAKFFIL 328
K +QRA++IE +I++A EC + NF+SL AI+S + + + RLKKTWA V + +
Sbjct: 334 ELKTQQRAKIIEKWINIAHECRLLKNFSSLRAIVSALQSNSIYRLKKTWAAVPRDRMLMF 393
Query: 329 EHQMD------------------PTGNFCNYRTALRGAAHRSLTAHSSREKI-----VIP 365
E D T F N ++++ R+ ++ + +P
Sbjct: 394 EELSDIFSDHNNHLTSRELLMKEGTSKFANLDSSVKENQKRTQRRLQLQKDMGVMQGTVP 453
Query: 366 FFSLLIKDIYFLNEGCANRLPNGHVNFEK 394
+ + D+ L+ + + G +NFEK
Sbjct: 454 YLGTFLTDLTMLDTALQDYIEGGLINFEK 482
>gi|7662334 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 2 [Homo sapiens]
Length = 689
Score = 76.3 bits (186), Expect = 6e-14
Identities = 91/394 (23%), Positives = 164/394 (41%), Gaps = 50/394 (12%)
Query: 67 LLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTETFPRDFQ 126
LL R ++ EL ++ LC+ + + +F K+ + W FP +F
Sbjct: 39 LLMHRWYLSSTELAEKL--LCMYRNATGESC------NEFRLKICYFMRYWILKFPAEFN 90
Query: 127 EESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISYRTKP 186
+ +G I +E +R+ QL H L + P + ++ R K
Sbjct: 91 LD---------LGLIRMTEE-FREVASQLGYEKHVSLIDISSIPS--YDWMRRVTQRKKV 138
Query: 187 PASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTS 246
LL +P LA+ LT +E + R I ++ Q++V L +
Sbjct: 139 SKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY-QSYVIHGCL--------ENNP 189
Query: 247 NLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMN 306
LE + FN + V + +QRA+VI FI+VA++ + NFN+LMA++ G++
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 307 MSPVSRLKKTWAKVR---TAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIV 363
S +SRLK+T + + T + + + GN+CNYR A + +
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAF-----------ADCDGFK 298
Query: 364 IPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITH 423
IP + +KD+ ++ + VN K +L+ + E ++ + E + + +
Sbjct: 299 IPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
Query: 424 YLYTA--PIFSEDGLY-----LASYESESPENQT 450
L + +ED +Y L S+SP + T
Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSPTSPT 392
>gi|26051258 RAS guanyl releasing protein 4 isoform a [Homo sapiens]
Length = 673
Score = 75.9 bits (185), Expect = 7e-14
Identities = 67/246 (27%), Positives = 111/246 (45%), Gaps = 25/246 (10%)
Query: 204 LAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVA 263
LAQ LT++E + I P++ ++++V + S + C + LE V N + V
Sbjct: 205 LAQHLTYLEFRSFQAITPQD-LRSYVLQ---GSVRGCPA-----LEGSVGLSNSVSRWVQ 255
Query: 264 TEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--- 320
+ QRAQV++ FI VA+ + NFN+LMA+ G+ S +SRLK + A +
Sbjct: 256 VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPD 315
Query: 321 RTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEG 380
T L + N+ YR G A L P + +KD+ L+E
Sbjct: 316 STKALLELTELLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLHEA 364
Query: 381 CANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTA--PIFSEDGLYL 438
+RLP+G ++ K L ++ E + + P + + H L + ++ED +Y
Sbjct: 365 QPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 424
Query: 439 ASYESE 444
SY E
Sbjct: 425 LSYARE 430
>gi|226246575 RAS guanyl releasing protein 4 isoform b [Homo
sapiens]
Length = 659
Score = 75.9 bits (185), Expect = 7e-14
Identities = 67/246 (27%), Positives = 111/246 (45%), Gaps = 25/246 (10%)
Query: 204 LAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVA 263
LAQ LT++E + I P++ ++++V + S + C + LE V N + V
Sbjct: 191 LAQHLTYLEFRSFQAITPQD-LRSYVLQ---GSVRGCPA-----LEGSVGLSNSVSRWVQ 241
Query: 264 TEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--- 320
+ QRAQV++ FI VA+ + NFN+LMA+ G+ S +SRLK + A +
Sbjct: 242 VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPD 301
Query: 321 RTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEG 380
T L + N+ YR G A L P + +KD+ L+E
Sbjct: 302 STKALLELTELLASHNNYARYRRTWAGCAGFRL-----------PVLGVHLKDLVSLHEA 350
Query: 381 CANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITHYLYTA--PIFSEDGLYL 438
+RLP+G ++ K L ++ E + + P + + H L + ++ED +Y
Sbjct: 351 QPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYE 410
Query: 439 ASYESE 444
SY E
Sbjct: 411 LSYARE 416
>gi|213385270 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 75.9 bits (185), Expect = 7e-14
Identities = 88/390 (22%), Positives = 163/390 (41%), Gaps = 45/390 (11%)
Query: 67 LLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTETFPRDFQ 126
LL R ++ EL ++ LC+ + + +F K+ + W FP +F
Sbjct: 39 LLMHRWYLSSTELAEKL--LCMYRNATGESC------NEFRLKICYFMRYWILKFPAEFN 90
Query: 127 EESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISYRTKP 186
+ +G I +E +R+ QL H L + P + ++ R K
Sbjct: 91 LD---------LGLIRMTEE-FREVASQLGYEKHVSLIDISSIPS--YDWMRRVTQRKKV 138
Query: 187 PASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTS 246
LL +P LA+ LT +E + R I ++ Q++V L +
Sbjct: 139 SKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY-QSYVIHGCL--------ENNP 189
Query: 247 NLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMN 306
LE + FN + V + +QRA+VI FI+VA++ + NFN+LMA++ G++
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 307 MSPVSRLKKTWAKVR---TAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIV 363
S +SRLK+T + + T + + + GN+CNYR A + +
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAF-----------ADCDGFK 298
Query: 364 IPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITH 423
IP + +KD+ ++ + VN K +L+ + E ++ + E + + +
Sbjct: 299 IPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
Query: 424 YLYTA--PIFSEDGLYLASYESESPENQTE 451
L + +ED +Y S E ++++
Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQ 388
>gi|24762239 RAS guanyl releasing protein 3 (calcium and
DAG-regulated) isoform 1 [Homo sapiens]
Length = 690
Score = 75.9 bits (185), Expect = 7e-14
Identities = 88/390 (22%), Positives = 163/390 (41%), Gaps = 45/390 (11%)
Query: 67 LLSSRLFIEPRELLARVCHLCIEQQQLDKPVLDKARVRKFGPKLLQLLAEWTETFPRDFQ 126
LL R ++ EL ++ LC+ + + +F K+ + W FP +F
Sbjct: 39 LLMHRWYLSSTELAEKL--LCMYRNATGESC------NEFRLKICYFMRYWILKFPAEFN 90
Query: 127 EESTIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISYRTKP 186
+ +G I +E +R+ QL H L + P + ++ R K
Sbjct: 91 LD---------LGLIRMTEE-FREVASQLGYEKHVSLIDISSIPS--YDWMRRVTQRKKV 138
Query: 187 PASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTS 246
LL +P LA+ LT +E + R I ++ Q++V L +
Sbjct: 139 SKKGKACLLFDHLEPIELAEHLTFLEHKSFRRISFTDY-QSYVIHGCL--------ENNP 189
Query: 247 NLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMN 306
LE + FN + V + +QRA+VI FI+VA++ + NFN+LMA++ G++
Sbjct: 190 TLERSIALFNGISKWVQLMVLSKPTPQQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLS 249
Query: 307 MSPVSRLKKTWAKVR---TAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIV 363
S +SRLK+T + + T + + + GN+CNYR A + +
Sbjct: 250 HSSISRLKETHSHLSSEVTKNWNEMTELVSSNGNYCNYRKAF-----------ADCDGFK 298
Query: 364 IPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQVGEFITWKQVECPFEQDASITH 423
IP + +KD+ ++ + VN K +L+ + E ++ + E + + +
Sbjct: 299 IPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQNASHHLEPNMDLIN 358
Query: 424 YLYTA--PIFSEDGLYLASYESESPENQTE 451
L + +ED +Y S E ++++
Sbjct: 359 LLTLSLDLYHTEDDIYKLSLVLEPRNSKSQ 388
>gi|7662070 Ral GEF with PH domain and SH3 binding motif 1 [Homo
sapiens]
Length = 557
Score = 72.8 bits (177), Expect = 6e-13
Identities = 70/304 (23%), Positives = 127/304 (41%), Gaps = 41/304 (13%)
Query: 170 PEGLVGAD----KPISYRTKPPASIHRELLGVCSDPYTLAQQLTHVELERLRHIGPEEFV 225
P+G +D + Y +K ++ ++L V P A Q+T +++ + I PEE
Sbjct: 18 PQGSSSSDSLEGQSCDYASKSYDAVVFDVLKVT--PEEFASQITLMDIPVFKAIQPEELA 75
Query: 226 QAFVNKDPLASTKPCFSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDV 285
+K S P N+ A+ + FN++ + V EI K RA+++ F+ +
Sbjct: 76 SCGWSKKEKHSLAP-------NVVAFTRRFNQVSFWVVREILTAQTLKIRAEILSHFVKI 128
Query: 286 ARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVR---TAKFFILEHQMDPTGNFCNYR 342
A++ + N +SLM+++S + +P+ RL KTWA + F L++ M N+ R
Sbjct: 129 AKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKEDNYKRTR 188
Query: 343 TALRGAAHRSLTAHSSREKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFLELAKQV 402
+R S + IP+ + + D+ +++ A + E+ +
Sbjct: 189 EYIR----------SLKMVPSIPYLGIYLLDLIYIDS--AYPASGSIMENEQRSNQMNNI 236
Query: 403 GEFITWKQVECPFEQDASITH---------YLYTAPIFSEDGLYLASYE----SESPENQ 449
I QV C ++ ++ H Y+ F ED Y S S SP
Sbjct: 237 LRIIADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFVEDDNYKLSLRIEPGSSSPRLV 296
Query: 450 TEKE 453
+ KE
Sbjct: 297 SSKE 300
>gi|154689780 son of sevenless homolog 2 [Homo sapiens]
Length = 1332
Score = 71.6 bits (174), Expect = 1e-12
Identities = 89/411 (21%), Positives = 168/411 (40%), Gaps = 69/411 (16%)
Query: 28 QAGQPLLDGAPSSASLETLIQHLVPTADYYPEKAYIFTFLLSSRLFIEPRELLARVCHLC 87
++G P++ G +E L H+ Y + ++ TFL + R F +P+ELL+ L
Sbjct: 593 RSGIPIIKGGTVVKLIERLTYHM------YADPNFVRTFLTTYRSFCKPQELLS----LL 642
Query: 88 IEQQQL--------DKPVLDK------ARVRKFGP--------KLLQLLAEWTETFPRDF 125
IE+ ++ DK ++K A +++F ++L + W E DF
Sbjct: 643 IERFEIPEPEPTDADKLAIEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDF 702
Query: 126 QEE-STIGHLKDVVGRIAPCDEAYRKRMHQLLQALHQKLAALRQGPEGLVGADKPISYRT 184
+ + + L+ + + +A +K + + + + +K A G + + P
Sbjct: 703 ERDLELLERLESFISSVR--GKAMKKWVESIAKIIRRKKQAQANGVSHNITFESP----- 755
Query: 185 KPPASIHRELLG-------VCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLAST 237
PP H G + P +A+QLT +E + R + P E V + K+
Sbjct: 756 PPPIEWHISKPGQFETFDLMTLHPIEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEIN 815
Query: 238 KPCFSDKTSNLEAYVKWFNRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNS 297
P + WF + C + A ++R V+ I++ + ++ NFN
Sbjct: 816 SPNLLKMIRHTTNLTLWFEK-CIVEAENF------EERVAVLSRIIEILQVFQDLNNFNG 868
Query: 298 LMAIISGMNMSPVSRLKKTWAKVRTAKFFILEHQMD-PTGNFCNYRTALRGAAHRSLTAH 356
++ I+S +N V RL T+ ++ K IL+ ++ +F Y L+
Sbjct: 869 VLEIVSAVNSVSVYRLDHTFEALQERKRKILDEAVELSQDHFKKYLVKLK---------- 918
Query: 357 SSREKIVIPFFSLLIKDIYFLNEGCANRLP---NGHVNFEKFLELAKQVGE 404
S +PFF + + +I EG + L +NF K ++A+ GE
Sbjct: 919 -SINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGE 968
>gi|38373677 guanine nucleotide-releasing factor 2 isoform b [Homo
sapiens]
Length = 1095
Score = 71.6 bits (174), Expect = 1e-12
Identities = 55/199 (27%), Positives = 97/199 (48%), Gaps = 15/199 (7%)
Query: 196 GVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWF 255
GV + P TL +H E+L + E F + + + L K +K+ NL + + F
Sbjct: 846 GVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEI-PEVLLWAKEQNEEKSPNLTQFTEHF 904
Query: 256 NRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKK 315
N + Y V + I + K + R +++ FI + + + NFNS +AI+S ++ +P+ RL+
Sbjct: 905 NNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE- 963
Query: 316 TWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIY 375
W K + +D + +F YR AL S E IP+ L+++D+
Sbjct: 964 -WQKQTSEGLAEYCTLIDSSSSFRAYRAAL-----------SEVEPPCIPYLGLILQDLT 1011
Query: 376 FLNEGCANRLPNGHVNFEK 394
F++ G + + +G VNF K
Sbjct: 1012 FVHLGNPDYI-DGKVNFSK 1029
>gi|38373675 guanine nucleotide-releasing factor 2 isoform a [Homo
sapiens]
Length = 1077
Score = 71.6 bits (174), Expect = 1e-12
Identities = 55/199 (27%), Positives = 97/199 (48%), Gaps = 15/199 (7%)
Query: 196 GVCSDPYTLAQQLTHVELERLRHIGPEEFVQAFVNKDPLASTKPCFSDKTSNLEAYVKWF 255
GV + P TL +H E+L + E F + + + L K +K+ NL + + F
Sbjct: 828 GVAARPGTLHDFHSHEIAEQLTLLDAELFYKIEI-PEVLLWAKEQNEEKSPNLTQFTEHF 886
Query: 256 NRLCYLVATEICMPAKKKQRAQVIEFFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKK 315
N + Y V + I + K + R +++ FI + + + NFNS +AI+S ++ +P+ RL+
Sbjct: 887 NNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLE- 945
Query: 316 TWAKVRTAKFFILEHQMDPTGNFCNYRTALRGAAHRSLTAHSSREKIVIPFFSLLIKDIY 375
W K + +D + +F YR AL S E IP+ L+++D+
Sbjct: 946 -WQKQTSEGLAEYCTLIDSSSSFRAYRAAL-----------SEVEPPCIPYLGLILQDLT 993
Query: 376 FLNEGCANRLPNGHVNFEK 394
F++ G + + +G VNF K
Sbjct: 994 FVHLGNPDYI-DGKVNFSK 1011
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,992,923
Number of Sequences: 37866
Number of extensions: 879549
Number of successful extensions: 2678
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 56
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2566
Number of HSP's gapped (non-prelim): 79
length of query: 466
length of database: 18,247,518
effective HSP length: 106
effective length of query: 360
effective length of database: 14,233,722
effective search space: 5124139920
effective search space used: 5124139920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.