Guide to the Human Genome
Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Search of human proteins with 40254844

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40254844 receptor-interacting serine-threonine kinase 3
[Homo sapiens]
         (518 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo...  1070   0.0  
gi|41327754 ankyrin repeat domain 3 [Homo sapiens]                    151   1e-36
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ...   145   9e-35
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas...   141   1e-33
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ...   135   7e-32
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]      108   1e-23
gi|155723000 mixed lineage kinase 4 [Homo sapiens]                    108   1e-23
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso...   107   3e-23
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso...   107   3e-23
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso...   105   8e-23
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof...   105   8e-23
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]          105   1e-22
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]        105   1e-22
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho...   103   5e-22
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H...   102   6e-22
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]             101   1e-21
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho...   101   1e-21
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]    101   2e-21
gi|32967311 ephrin receptor EphA2 [Homo sapiens]                      100   2e-21
gi|221316650 ephrin receptor EphA1 [Homo sapiens]                     100   5e-21
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]                97   3e-20
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]                97   3e-20
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap...    97   5e-20
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi...    97   5e-20
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H...    96   8e-20
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom...    96   8e-20
gi|130977759 tec protein tyrosine kinase [Homo sapiens]                95   1e-19
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]           94   2e-19
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]            94   2e-19
gi|148596974 TXK tyrosine kinase [Homo sapiens]                        94   2e-19

>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
           sapiens]
          Length = 518

 Score = 1070 bits (2767), Expect = 0.0
 Identities = 518/518 (100%), Positives = 518/518 (100%)

Query: 1   MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE 60
           MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
Sbjct: 1   MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE 60

Query: 61  VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL 120
           VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
Sbjct: 61  VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL 120

Query: 121 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG 180
           LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
Sbjct: 121 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG 180

Query: 181 GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP 240
           GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
Sbjct: 181 GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP 240

Query: 241 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST 300
           SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
Sbjct: 241 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST 300

Query: 301 VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS 360
           VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
Sbjct: 301 VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS 360

Query: 361 VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG 420
           VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
Sbjct: 361 VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG 420

Query: 421 PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA 480
           PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
Sbjct: 421 PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA 480

Query: 481 PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK 518
           PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
Sbjct: 481 PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK 518


>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
          Length = 784

 Score =  151 bits (382), Expect = 1e-36
 Identities = 98/284 (34%), Positives = 144/284 (50%), Gaps = 19/284 (6%)

Query: 20  ELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAIS--------REVKAMASLDNEF 71
           E    E VG GGFG V++ +H  W   +A+K   S  +          E K M      +
Sbjct: 21  EFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80

Query: 72  VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYL 131
           +L + G+  +          LV ++ME GSL  LL S+ P PW L  R++ E  +GM +L
Sbjct: 81  ILPVYGICRE-------PVGLVMEYMETGSLEKLLASE-PLPWDLRFRIIHETAVGMNFL 132

Query: 132 HDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEP-GGTLGYLAPEL 190
           H   P LLH DLKP+N+LLD   HVK++DFGL+   G S S   S +   GT+ YL PE 
Sbjct: 133 HCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPER 192

Query: 191 FVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGP 250
               +R   T  DVYSF I++W VL  ++     +  L       + +RP L  + +A P
Sbjct: 193 IREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARP 252

Query: 251 ETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNM 294
                  L  LMQ CW  +P+ RP+FQE   +T+++ +  ++ +
Sbjct: 253 R--ACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEV 294


>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
           sapiens]
          Length = 540

 Score =  145 bits (366), Expect = 9e-35
 Identities = 99/297 (33%), Positives = 157/297 (52%), Gaps = 28/297 (9%)

Query: 14  PLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVN---------SKAISREVKAM 64
           P +   +L +   + +G  GTV  A+H  W   VAVK ++          K + RE + +
Sbjct: 11  PTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEIL 70

Query: 65  ASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRP---WPLLCRLL 121
                 ++L + G+  +  +       +VT++M NGSL+ LL  +   P   WPL  R+L
Sbjct: 71  HKARFSYILPILGICNEPEF-----LGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125

Query: 122 KEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQ--GGSQSGTGSGEP 179
            E+ LG+ YLH+  P LLH DLK  N+LLD E HVK+ADFGLS ++    SQS +    P
Sbjct: 126 HEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAP 185

Query: 180 -GGTLGYLAPELF-VNVNRKASTASDVYSFGILMWAVLAGRE-VELPTEPSLVYEAVCNR 236
            GGT+ Y+ PE +      +AS   D+YS+ ++ W VL+ ++  E  T P  +  +V ++
Sbjct: 186 EGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSV-SQ 244

Query: 237 QNRPSLAE--LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE 291
            +RP + E  LP    + P    +  L++  W+  P +RPSF +CL + + V +  E
Sbjct: 245 GHRPVINEESLPY---DIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 298


>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
           [Homo sapiens]
          Length = 671

 Score =  141 bits (356), Expect = 1e-33
 Identities = 101/299 (33%), Positives = 160/299 (53%), Gaps = 53/299 (17%)

Query: 17  SIEELENQELVGKGGFGTVFRAQHRKWG-------YDVAVKIVNSKAISREVKAMASLDN 69
           S + LE+ EL   GGFG V    HR  G       Y     I +++A+  E K M  L +
Sbjct: 14  SSDFLESAEL-DSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRH 72

Query: 70  EFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMF 129
             V++L GVI      ++ K +LV ++ME G+L  +L+++   P  +  R++ E++ GM 
Sbjct: 73  SRVVKLLGVII-----EEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMC 127

Query: 130 YLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ------------SGTGSG 177
           YLH +   ++H+DLKP N+L+D + H+K+AD GL++F+  S+             GT   
Sbjct: 128 YLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK- 184

Query: 178 EPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQ 237
           + GGTL Y+APE   +VN K +  SDVYSF +++WA+ A +E   P E      A+C +Q
Sbjct: 185 KNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKE---PYE-----NAICEQQ 236

Query: 238 --------NRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
                   NRP + ++ +  P       +  LM+LCW + P+ RP+F    P  +E F+
Sbjct: 237 LIMCIKSGNRPDVDDITEYCPRE-----IISLMKLCWEANPEARPTF----PGIEEKFR 286


>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
           sapiens]
          Length = 765

 Score =  135 bits (341), Expect = 7e-32
 Identities = 90/296 (30%), Positives = 144/296 (48%), Gaps = 28/296 (9%)

Query: 14  PLVSIEELENQ-ELVGKGGFGTVFRAQHRKWGYDVAVKIV----------NSKAISREVK 62
           P+ + ++ E    LV  GGF  VF+A+HR+W  + A+K            +   +  E  
Sbjct: 14  PVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAA 73

Query: 63  AMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQ--SQCPRPWPLLCRL 120
            M  +  + ++ + GV ++          +V +FM NGSL  +L   S C   W L  R+
Sbjct: 74  KMKKIKFQHIVSIYGVCKQ-------PLGIVMEFMANGSLEKVLSTHSLC---WKLRFRI 123

Query: 121 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQSGTGSGE 178
           + E  L M +LH   P LLH DLKP N+LLD  +HVK++DFGLS +  Q           
Sbjct: 124 IHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSA 183

Query: 179 PGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQN 238
             G L Y+ PE+F+  N+      DVYSF I++W +L  ++        ++   V     
Sbjct: 184 LRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGM- 242

Query: 239 RPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNM 294
           RPSL  +    P     + + +LM+ CW  +PK RP F +   +TD +  ++++ +
Sbjct: 243 RPSLQPVSDQWPSE--AQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRV 296


>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
          Length = 513

 Score =  108 bits (270), Expect = 1e-23
 Identities = 94/298 (31%), Positives = 144/298 (48%), Gaps = 43/298 (14%)

Query: 12  PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIV-----NSKAISREVKAMAS 66
           P+PL+ ++ L+  E+  +G FG V++AQ       VAVKI       S     EV ++  
Sbjct: 183 PSPLLGLKPLQLLEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNEYEVYSLPG 240

Query: 67  LDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVL 126
           + +E +L+  G  EK     D    L+T F E GSLS  L++     W  LC + + +  
Sbjct: 241 MKHENILQFIGA-EKRGTSVDVDLWLITAFHEKGSLSDFLKANVVS-WNELCHIAETMAR 298

Query: 127 GMFYLHDQ--------NPVLLHRDLKPSNVLLDPELHVKLADFGLS-TFQGGSQSGTGSG 177
           G+ YLH+          P + HRD+K  NVLL   L   +ADFGL+  F+ G  +G   G
Sbjct: 299 GLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHG 358

Query: 178 EPGGTLGYLAPELF---VNVNRKASTASDVYSFGILMWAVLAGR---------------E 219
           +  GT  Y+APE+    +N  R A    D+Y+ G+++W  LA R               E
Sbjct: 359 QV-GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWE-LASRCTAADGPVDEYMLPFE 416

Query: 220 VELPTEPSL--VYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPS 275
            E+   PSL  + E V +++ RP L +  Q   +  G+  L E ++ CW  + + R S
Sbjct: 417 EEIGQHPSLEDMQEVVVHKKKRPVLRDYWQ---KHAGMAMLCETIEECWDHDAEARLS 471


>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
          Length = 1036

 Score =  108 bits (270), Expect = 1e-23
 Identities = 131/494 (26%), Positives = 204/494 (41%), Gaps = 94/494 (19%)

Query: 8   PSGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVN----------SKA 56
           PS   +P+ V+ E LE +EL+G GGFG V+RA  +  G +VAVK             +++
Sbjct: 110 PSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAES 167

Query: 57  ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWP- 115
           + RE +  A L +  ++ L GV       Q P   LV +F   G+L+  L +    P P 
Sbjct: 168 VRREARLFAMLRHPNIIELRGVCL-----QQPHLCLVLEFARGGALNRALAAANAAPDPR 222

Query: 116 -------------LLCRLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLLDPELH------ 155
                        +L     ++  GM YLH++  V +LHRDLK SN+LL  ++       
Sbjct: 223 APGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICN 282

Query: 156 --VKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWA 213
             +K+ DFGL+         T      GT  ++APE  V  +   S  SD++S+G+L+W 
Sbjct: 283 KTLKITDFGLAR----EWHRTTKMSTAGTYAWMAPE--VIKSSLFSKGSDIWSYGVLLWE 336

Query: 214 VLAGREVELPTEP----SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSE 269
           +L G   E+P       ++ Y    N+   P    +P   PE        +LM+ CW  +
Sbjct: 337 LLTG---EVPYRGIDGLAVAYGVAVNKLTLP----IPSTCPEP-----FAKLMKECWQQD 384

Query: 270 PKDRPSFQECLPK------------TDEVFQMVENNMNAAVSTVKDFL----SQLRSSNR 313
           P  RPSF   L +              E F  ++++    +  + D L     +LRS   
Sbjct: 385 PHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREE 444

Query: 314 RFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSE---WLNKLNLEEPPSSVPKKCPSLTK 370
             +     Q   E    RR  +      DV+  E    + +LN E+P     KK     K
Sbjct: 445 ELTRAALQQKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPK---VKKRKGKFK 501

Query: 371 RSRAQEEQVPQAWTAGTSSD-----SMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQ 425
           RSR    ++         SD     ++   P   +  +  +   SP S+ T  P  R  Q
Sbjct: 502 RSRL---KLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQ 558

Query: 426 -GAERQGMNWSCRT 438
             ++     W   T
Sbjct: 559 LTSDESNKTWGRNT 572


>gi|21735564 mitogen-activated protein kinase kinase kinase 7
           isoform C [Homo sapiens]
          Length = 518

 Score =  107 bits (267), Expect = 3e-23
 Identities = 128/475 (26%), Positives = 203/475 (42%), Gaps = 69/475 (14%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS----KAISREVKAMASLDNEF 71
           +  +E+E +E+VG+G FG V +A+ R    DVA+K + S    KA   E++ ++ +++  
Sbjct: 31  IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVNHPN 88

Query: 72  VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLK---EVVLGM 128
           +++L G              LV ++ E GSL  +L    P P+      +    +   G+
Sbjct: 89  IVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141

Query: 129 FYLHDQNP-VLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
            YLH   P  L+HRDLKP N+LL     V K+ DFG +         T      G+  ++
Sbjct: 142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTHMTNNKGSAAWM 196

Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREV--ELPTEPSLVYEAVCNRQNRPSLAE 244
           APE+F   N   S   DV+S+GI++W V+  R+   E+      +  AV N    P +  
Sbjct: 197 APEVFEGSNY--SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN 254

Query: 245 LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL----------PKTDEVFQMV---- 290
           LP+          ++ LM  CWS +P  RPS +E +          P  DE  Q      
Sbjct: 255 LPKP---------IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYS 305

Query: 291 -ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWL 349
            E   N+A ST   F+    ++    S     Q     D  +R +E++  +N        
Sbjct: 306 DEGQSNSATST-GSFMDIASTNTSNKSDTNMEQVPATNDTIKR-LESKLLKNQAKQQSES 363

Query: 350 NKLNLEEPPSSVPKKCP--SLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRN- 406
            +L+L     S  +  P  S  KR  A   ++ +A  A T++ S  +     +T++F N 
Sbjct: 364 GRLSLGASRGSSVESLPPTSEGKRMSADMSEI-EARIAATTAYSKPKRGHR-KTASFGNI 421

Query: 407 -QMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGR---PLVNIYNCSG 457
             +P    +G   P  R  Q     G        EP  V+ R   P V +   SG
Sbjct: 422 LDVPEIVISGNGQPRRRSIQDLTVTG-------TEPGQVSSRSSSPSVRMITTSG 469


>gi|21735562 mitogen-activated protein kinase kinase kinase 7
           isoform B [Homo sapiens]
          Length = 606

 Score =  107 bits (267), Expect = 3e-23
 Identities = 128/475 (26%), Positives = 203/475 (42%), Gaps = 69/475 (14%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS----KAISREVKAMASLDNEF 71
           +  +E+E +E+VG+G FG V +A+ R    DVA+K + S    KA   E++ ++ +++  
Sbjct: 31  IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVNHPN 88

Query: 72  VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLK---EVVLGM 128
           +++L G              LV ++ E GSL  +L    P P+      +    +   G+
Sbjct: 89  IVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141

Query: 129 FYLHDQNP-VLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
            YLH   P  L+HRDLKP N+LL     V K+ DFG +         T      G+  ++
Sbjct: 142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTHMTNNKGSAAWM 196

Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREV--ELPTEPSLVYEAVCNRQNRPSLAE 244
           APE+F   N   S   DV+S+GI++W V+  R+   E+      +  AV N    P +  
Sbjct: 197 APEVFEGSNY--SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN 254

Query: 245 LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL----------PKTDEVFQMV---- 290
           LP+          ++ LM  CWS +P  RPS +E +          P  DE  Q      
Sbjct: 255 LPKP---------IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYS 305

Query: 291 -ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWL 349
            E   N+A ST   F+    ++    S     Q     D  +R +E++  +N        
Sbjct: 306 DEGQSNSATST-GSFMDIASTNTSNKSDTNMEQVPATNDTIKR-LESKLLKNQAKQQSES 363

Query: 350 NKLNLEEPPSSVPKKCP--SLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRN- 406
            +L+L     S  +  P  S  KR  A   ++ +A  A T++ S  +     +T++F N 
Sbjct: 364 GRLSLGASRGSSVESLPPTSEGKRMSADMSEI-EARIAATTAYSKPKRGHR-KTASFGNI 421

Query: 407 -QMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGR---PLVNIYNCSG 457
             +P    +G   P  R  Q     G        EP  V+ R   P V +   SG
Sbjct: 422 LDVPEIVISGNGQPRRRSIQDLTVTG-------TEPGQVSSRSSSPSVRMITTSG 469


>gi|21735566 mitogen-activated protein kinase kinase kinase 7
           isoform D [Homo sapiens]
          Length = 491

 Score =  105 bits (263), Expect = 8e-23
 Identities = 116/435 (26%), Positives = 189/435 (43%), Gaps = 57/435 (13%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS----KAISREVKAMASLDNEF 71
           +  +E+E +E+VG+G FG V +A+ R    DVA+K + S    KA   E++ ++ +++  
Sbjct: 31  IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVNHPN 88

Query: 72  VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLK---EVVLGM 128
           +++L G              LV ++ E GSL  +L    P P+      +    +   G+
Sbjct: 89  IVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141

Query: 129 FYLHDQNP-VLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
            YLH   P  L+HRDLKP N+LL     V K+ DFG +         T      G+  ++
Sbjct: 142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTHMTNNKGSAAWM 196

Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREV--ELPTEPSLVYEAVCNRQNRPSLAE 244
           APE+F   N   S   DV+S+GI++W V+  R+   E+      +  AV N    P +  
Sbjct: 197 APEVFEGSNY--SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN 254

Query: 245 LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL----------PKTDEVFQMV---- 290
           LP+          ++ LM  CWS +P  RPS +E +          P  DE  Q      
Sbjct: 255 LPKP---------IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYS 305

Query: 291 -ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWL 349
            E   N+A ST   F+    ++    S     Q     D  +R +E++  +N        
Sbjct: 306 DEGQSNSATST-GSFMDIASTNTSNKSDTNMEQVPATNDTIKR-LESKLLKNQAKQQSES 363

Query: 350 NKLNLEEPPSSVPKKCP--SLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQ 407
            +L+L     S  +  P  S  KR  A   ++ +A  A T+ +   +  ++ +  T    
Sbjct: 364 GRLSLGASRGSSVESLPPTSEGKRMSADMSEI-EARIAATTGNGQPR-RRSIQDLTVTGT 421

Query: 408 MPSPTSTGTPSPGPR 422
            P   S+ + SP  R
Sbjct: 422 EPGQVSSRSSSPSVR 436


>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
           A [Homo sapiens]
          Length = 579

 Score =  105 bits (263), Expect = 8e-23
 Identities = 116/435 (26%), Positives = 189/435 (43%), Gaps = 57/435 (13%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS----KAISREVKAMASLDNEF 71
           +  +E+E +E+VG+G FG V +A+ R    DVA+K + S    KA   E++ ++ +++  
Sbjct: 31  IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVNHPN 88

Query: 72  VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLK---EVVLGM 128
           +++L G              LV ++ E GSL  +L    P P+      +    +   G+
Sbjct: 89  IVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141

Query: 129 FYLHDQNP-VLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
            YLH   P  L+HRDLKP N+LL     V K+ DFG +         T      G+  ++
Sbjct: 142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTHMTNNKGSAAWM 196

Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREV--ELPTEPSLVYEAVCNRQNRPSLAE 244
           APE+F   N   S   DV+S+GI++W V+  R+   E+      +  AV N    P +  
Sbjct: 197 APEVFEGSNY--SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN 254

Query: 245 LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL----------PKTDEVFQMV---- 290
           LP+          ++ LM  CWS +P  RPS +E +          P  DE  Q      
Sbjct: 255 LPKP---------IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYS 305

Query: 291 -ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWL 349
            E   N+A ST   F+    ++    S     Q     D  +R +E++  +N        
Sbjct: 306 DEGQSNSATST-GSFMDIASTNTSNKSDTNMEQVPATNDTIKR-LESKLLKNQAKQQSES 363

Query: 350 NKLNLEEPPSSVPKKCP--SLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQ 407
            +L+L     S  +  P  S  KR  A   ++ +A  A T+ +   +  ++ +  T    
Sbjct: 364 GRLSLGASRGSSVESLPPTSEGKRMSADMSEI-EARIAATTGNGQPR-RRSIQDLTVTGT 421

Query: 408 MPSPTSTGTPSPGPR 422
            P   S+ + SP  R
Sbjct: 422 EPGQVSSRSSSPSVR 436


>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
          Length = 835

 Score =  105 bits (261), Expect = 1e-22
 Identities = 97/351 (27%), Positives = 159/351 (45%), Gaps = 34/351 (9%)

Query: 4   VKLWPSGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKA------ 56
           + L  +G P+   + + E+E  E++G G FG V++ + R     VA+K   +        
Sbjct: 445 ILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSD 502

Query: 57  ---ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKP-ALVTKFMENGSLSGLLQSQCPR 112
                REV  +  L++  V++  G         DP   A+VT+++  GSL  LL  Q  R
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLN-----DPSQFAIVTQYISGGSLFSLLHEQ-KR 556

Query: 113 PWPLLCRLL--KEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGS 170
              L  +L+   +V  GM YLH+    ++HRDL   N+LL  + H  +ADFG S F    
Sbjct: 557 ILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL 616

Query: 171 QSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVY 230
                + +P G L ++APE+F    R    A DV+S+ + +W +L G       +P+   
Sbjct: 617 DEDNMTKQP-GNLRWMAPEVFTQCTRYTIKA-DVFSYALCLWEILTGEIPFAHLKPAAAA 674

Query: 231 EAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMV 290
             +     RP +      G   P  + +  L+   W++ P+ RP F E + K +E    +
Sbjct: 675 ADMAYHHIRPPI------GYSIP--KPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNI 726

Query: 291 ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRN 341
           E  M+ A S     LS   SS+    +   G G + +   R   E +++ N
Sbjct: 727 E-LMSPASSNSSGSLSP--SSSSDCLVNRGGPGRSHVAALRSRFELEYALN 774


>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
          Length = 936

 Score =  105 bits (261), Expect = 1e-22
 Identities = 97/351 (27%), Positives = 159/351 (45%), Gaps = 34/351 (9%)

Query: 4   VKLWPSGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKA------ 56
           + L  +G P+   + + E+E  E++G G FG V++ + R     VA+K   +        
Sbjct: 546 ILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSD 603

Query: 57  ---ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKP-ALVTKFMENGSLSGLLQSQCPR 112
                REV  +  L++  V++  G         DP   A+VT+++  GSL  LL  Q  R
Sbjct: 604 VDMFCREVSILCQLNHPCVIQFVGACLN-----DPSQFAIVTQYISGGSLFSLLHEQ-KR 657

Query: 113 PWPLLCRLL--KEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGS 170
              L  +L+   +V  GM YLH+    ++HRDL   N+LL  + H  +ADFG S F    
Sbjct: 658 ILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL 717

Query: 171 QSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVY 230
                + +P G L ++APE+F    R    A DV+S+ + +W +L G       +P+   
Sbjct: 718 DEDNMTKQP-GNLRWMAPEVFTQCTRYTIKA-DVFSYALCLWEILTGEIPFAHLKPAAAA 775

Query: 231 EAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMV 290
             +     RP +      G   P  + +  L+   W++ P+ RP F E + K +E    +
Sbjct: 776 ADMAYHHIRPPI------GYSIP--KPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNI 827

Query: 291 ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRN 341
           E  M+ A S     LS   SS+    +   G G + +   R   E +++ N
Sbjct: 828 E-LMSPASSNSSGSLSP--SSSSDCLVNRGGPGRSHVAALRSRFELEYALN 875


>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
           sapiens]
          Length = 1118

 Score =  103 bits (256), Expect = 5e-22
 Identities = 96/337 (28%), Positives = 156/337 (46%), Gaps = 62/337 (18%)

Query: 12  PAPLVSIE--ELENQELVGKGGFGTVFRAQHRKW-GYDVAVKIVNS----------KAIS 58
           P  L+ I+  EL  +E++G GGFG V+RA    W G +VAVK              + + 
Sbjct: 133 PIQLLEIDFAELTLEEIIGIGGFGKVYRAF---WIGDEVAVKAARHDPDEDISQTIENVR 189

Query: 59  REVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLC 118
           +E K  A L +  ++ L GV  K     +P   LV +F   G L+ +L  +   P  +L 
Sbjct: 190 QEAKLFAMLKHPNIIALRGVCLK-----EPNLCLVMEFARGGPLNRVLSGKRIPP-DILV 243

Query: 119 RLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLLDPELH--------VKLADFGLSTFQGG 169
               ++  GM YLHD+  V ++HRDLK SN+L+  ++         +K+ DFGL+     
Sbjct: 244 NWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---- 299

Query: 170 SQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEP--- 226
               T      GT  ++APE+        S  SDV+S+G+L+W +L G   E+P      
Sbjct: 300 EWHRTTKMSAAGTYAWMAPEVIRA--SMFSKGSDVWSYGVLLWELLTG---EVPFRGIDG 354

Query: 227 -SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE 285
            ++ Y    N+   P    +P   PE        +LM+ CW+ +P  RPSF   L +   
Sbjct: 355 LAVAYGVAMNKLALP----IPSTCPEP-----FAKLMEDCWNPDPHSRPSFTNILDQLTT 405

Query: 286 V-----FQMVENNMNAAVST----VKDFLSQLRSSNR 313
           +     F+M +++ +         +++   QLR+  +
Sbjct: 406 IEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEK 442


>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
           sapiens]
          Length = 954

 Score =  102 bits (255), Expect = 6e-22
 Identities = 88/305 (28%), Positives = 144/305 (47%), Gaps = 50/305 (16%)

Query: 8   PSGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVK----------IVNSKA 56
           P+G   P  +   EL+ +E++G GGFG V+RA  R  G +VAVK           V ++ 
Sbjct: 84  PAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWR--GEEVAVKAARLDPEKDPAVTAEQ 141

Query: 57  ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL 116
           + +E +   +L +  ++ L G          P   LV ++   G+LS +L  +   P  +
Sbjct: 142 VCQEARLFGALQHPNIIALRGACL-----NPPHLCLVMEYARGGALSRVLAGRRVPP-HV 195

Query: 117 LCRLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLLDPELH--------VKLADFGLSTFQ 167
           L     +V  GM YLH+  PV ++HRDLK  N+L+   +         +K+ DFGL+   
Sbjct: 196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR-- 253

Query: 168 GGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAG----REVELP 223
                 T      GT  ++APE+ + ++   S +SDV+SFG+L+W +L G    RE++  
Sbjct: 254 --EWHKTTKMSAAGTYAWMAPEV-IRLS-LFSKSSDVWSFGVLLWELLTGEVPYREID-- 307

Query: 224 TEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKT 283
              ++ Y    N+   P    +P   PE         L++ CW  +P  RP F   L + 
Sbjct: 308 -ALAVAYGVAMNKLTLP----IPSTCPEP-----FARLLEECWDPDPHGRPDFGSILKRL 357

Query: 284 DEVFQ 288
           + + Q
Sbjct: 358 EVIEQ 362


>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
          Length = 984

 Score =  101 bits (252), Expect = 1e-21
 Identities = 84/289 (29%), Positives = 140/289 (48%), Gaps = 35/289 (12%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYD---VAVKIVNS-------KAISREVKAMA 65
           + +  ++ +E++G G FG V++ + +  G     VA+K + +       +    E   M 
Sbjct: 614 IDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMG 673

Query: 66  SLDNEFVLRLEGVIEKVNWDQDPKPALV-TKFMENGSLSGLLQSQCPRPWPL-LCRLLKE 123
             D+  ++RLEGV+ K       +P ++ T+FMENG+L   L+    +   + L  +L+ 
Sbjct: 674 QFDHPNIIRLEGVVTK------SRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRG 727

Query: 124 VVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF-QGGSQSGTGSGEPGGT 182
           +  GM YL + N V  HRDL   N+L++  L  K++DFGLS + Q  +   T +   GG 
Sbjct: 728 IAAGMKYLAEMNYV--HRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGK 785

Query: 183 L--GYLAPELFVNVNRKASTASDVYSFGILMWAVLA-GREVELPTEPSLVYEAVCNRQNR 239
           +   + APE      RK ++ASDV+S+GI+MW V++ G           V  A+      
Sbjct: 786 IPVRWTAPEAI--AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRL 843

Query: 240 PSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
           P   + P A         L +LM  CW  +   RP F E +   D++ +
Sbjct: 844 PPPMDCPAA---------LHQLMLDCWQKDRNSRPRFAEIVNTLDKMIR 883


>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
           sapiens]
          Length = 847

 Score =  101 bits (252), Expect = 1e-21
 Identities = 93/309 (30%), Positives = 143/309 (46%), Gaps = 55/309 (17%)

Query: 12  PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKI----------VNSKAISREV 61
           P  + S +EL  +E++G GGFG V+R   R  G  VAVK           V ++++ +E 
Sbjct: 108 PCEVASFQELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEA 165

Query: 62  KAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLL 121
           +  A L +  ++ L+ V       ++P   LV ++   G LS  L  +   P  +L    
Sbjct: 166 RLFAMLAHPNIIALKAVCL-----EEPNLCLVMEYAAGGPLSRALAGRRVPP-HVLVNWA 219

Query: 122 KEVVLGMFYLHDQNPV-LLHRDLKPSNVLL------DPELH--VKLADFGLSTFQGGSQS 172
            ++  GM YLH +  V ++HRDLK +N+LL      D   H  +K+ DFGL+        
Sbjct: 220 VQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR----EWH 275

Query: 173 GTGSGEPGGTLGYLAPELFVNVNRKAST---ASDVYSFGILMWAVLAGREVELPTEP--- 226
            T      GT  ++APE+      KAST    SDV+SFG+L+W +L G   E+P      
Sbjct: 276 KTTQMSAAGTYAWMAPEVI-----KASTFSKGSDVWSFGVLLWELLTG---EVPYRGIDC 327

Query: 227 -SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE 285
            ++ Y    N+   P    +P   PE        +LM  CW+ +P  RP F   L + + 
Sbjct: 328 LAVAYGVAVNKLTLP----IPSTCPEP-----FAQLMADCWAQDPHRRPDFASILQQLEA 378

Query: 286 VFQMVENNM 294
           +   V   M
Sbjct: 379 LEAQVLREM 387



 Score = 36.2 bits (82), Expect = 0.074
 Identities = 42/170 (24%), Positives = 67/170 (39%), Gaps = 17/170 (10%)

Query: 352 LNLEEPPSSVPKKCPSLTKRSRAQEEQVPQ--AWTAGTSSDSMAQPPQTPETSTFRNQMP 409
           L  EEP   VP +  S +   +  +  + +  A  A        QPP  P     R +  
Sbjct: 618 LEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPG----RERGE 673

Query: 410 SPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQ 469
           SPT+  TP+P P   +      + +S +TP+  P     L+++    G+ VG  +  + +
Sbjct: 674 SPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDL----GIPVGQRSAKSPR 729

Query: 470 QT------TALPTWGLAPSGKGR-GLQHPPPVGSQEGPKDPEAWSRPQGW 512
           +       T  P  G + S  G  G    PP+G    P+     SR   W
Sbjct: 730 REEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPW 779


>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
          Length = 512

 Score =  101 bits (251), Expect = 2e-21
 Identities = 97/341 (28%), Positives = 160/341 (46%), Gaps = 49/341 (14%)

Query: 12  PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIV-----NSKAISREVKAMAS 66
           P+PLV ++ L+  E+  +G FG V++AQ       VAVKI       S    RE+ +   
Sbjct: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQ--LMNDFVAVKIFPLQDKQSWQSEREIFSTPG 238

Query: 67  LDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVL 126
           + +E +L+     EK   + + +  L+T F + GSL+  L+      W  LC + + +  
Sbjct: 239 MKHENLLQFIAA-EKRGSNLEVELWLITAFHDKGSLTDYLKGNIIT-WNELCHVAETMSR 296

Query: 127 GMFYLHDQ---------NPVLLHRDLKPSNVLLDPELHVKLADFGLST-FQGGSQSGTGS 176
           G+ YLH+           P + HRD K  NVLL  +L   LADFGL+  F+ G   G   
Sbjct: 297 GLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTH 356

Query: 177 GEPGGTLGYLAPELF---VNVNRKASTASDVYSFGILMWAVLA--------------GRE 219
           G+  GT  Y+APE+    +N  R A    D+Y+ G+++W +++                E
Sbjct: 357 GQV-GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFE 415

Query: 220 VELPTEPSL--VYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQ 277
            E+   PSL  + E V +++ RP++ +      + PGL  L   ++ CW  + + R S  
Sbjct: 416 EEIGQHPSLEELQEVVVHKKMRPTIKD---HWLKHPGLAQLCVTIEECWDHDAEARLS-A 471

Query: 278 ECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIP 318
            C+   +E   ++  ++N    T  D L  L +S     +P
Sbjct: 472 GCV---EERVSLIRRSVN---GTTSDCLVSLVTSVTNVDLP 506


>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
          Length = 976

 Score =  100 bits (250), Expect = 2e-21
 Identities = 98/348 (28%), Positives = 153/348 (43%), Gaps = 58/348 (16%)

Query: 24  QELVGKGGFGTVFRAQHR----KWGYDVAVKIVNSKAISR-------EVKAMASLDNEFV 72
           Q+++G G FG V++   +    K    VA+K + +    +       E   M    +  +
Sbjct: 616 QKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNI 675

Query: 73  LRLEGVIEKVNWDQDPKPALV-TKFMENGSLSGLLQSQCPRPWPL-LCRLLKEVVLGMFY 130
           +RLEGVI K       KP ++ T++MENG+L   L+ +      L L  +L+ +  GM Y
Sbjct: 676 IRLEGVISKY------KPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKY 729

Query: 131 LHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGT-LGYLAPE 189
           L + N V  HRDL   N+L++  L  K++DFGLS         T +   G   + + APE
Sbjct: 730 LANMNYV--HRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE 787

Query: 190 LFVNVNRKASTASDVYSFGILMWAVLA-GREVELPTEPSLVYEAVCNRQNRPSLAELPQA 248
                 RK ++ASDV+SFGI+MW V+  G           V +A+ +    P+  + P A
Sbjct: 788 AISY--RKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSA 845

Query: 249 GPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQL 308
                    + +LM  CW  E   RP F + +   D++ +              D L  L
Sbjct: 846 ---------IYQLMMQCWQQERARRPKFADIVSILDKLIR------------APDSLKTL 884

Query: 309 RSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEE 356
              + R SI      G+E   FR             VSEWL  + +++
Sbjct: 885 ADFDPRVSIRLPSTSGSEGVPFR------------TVSEWLESIKMQQ 920


>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
          Length = 976

 Score = 99.8 bits (247), Expect = 5e-21
 Identities = 85/268 (31%), Positives = 131/268 (48%), Gaps = 36/268 (13%)

Query: 26  LVGKGGFGTVFRAQHRKWGYD---VAVKIVNSKA-------ISREVKAMASLDNEFVLRL 75
           ++G+G FG V+R   R    D   VA+K +   +         RE   M    +  +L L
Sbjct: 629 VIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHL 688

Query: 76  EGVIEKVNWDQDPKPALV-TKFMENGSLSGLLQSQCPRPWP-LLCRLLKEVVLGMFYLHD 133
           EGV+ K       KP ++ T+FMENG+L   L+ +  +  P  L  +L+ +  GM YL +
Sbjct: 689 EGVVTK------RKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSN 742

Query: 134 QNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQG---GSQSGTGSGEPGGTLGYLAPEL 190
            N V  HRDL   N+L++  L  K++DFGL+       G+    G   P   + + APE 
Sbjct: 743 HNYV--HRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIP---IRWTAPEA 797

Query: 191 FVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGP 250
             +  R  +TASDV+SFGI+MW VL+  +          Y  + N++   S+ +  +  P
Sbjct: 798 IAH--RIFTTASDVWSFGIVMWEVLSFGDKP--------YGEMSNQEVMKSIEDGYRLPP 847

Query: 251 ETPGLEGLKELMQLCWSSEPKDRPSFQE 278
                  L ELM+ CW+ +   RP FQ+
Sbjct: 848 PVDCPAPLYELMKNCWAYDRARRPHFQK 875


>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
          Length = 455

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 78/274 (28%), Positives = 133/274 (48%), Gaps = 24/274 (8%)

Query: 10  GAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDN 69
           GA    +  ++L+  E  G G FG+V+RA+      +VAVK +    I +E + ++ L +
Sbjct: 5   GASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK--IEKEAEILSVLSH 62

Query: 70  EFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL--LCRLLKEVVLG 127
             +++  GVI      + P   +VT++   GSL   + S       +  +     +V  G
Sbjct: 63  RNIIQFYGVIL-----EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117

Query: 128 MFYLHDQNPV-LLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
           M YLH + PV ++HRDLK  NV++  +  +K+ DFG S F     + T      GT  ++
Sbjct: 118 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF----HNHTTHMSLVGTFPWM 173

Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELP 246
           APE+  ++    S   D YS+G+++W +L  REV       L    +   +N      +P
Sbjct: 174 APEVIQSL--PVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKN--ERLTIP 228

Query: 247 QAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL 280
            + P +       EL+  CW ++ K RPSF++ +
Sbjct: 229 SSCPRS-----FAELLHQCWEADAKKRPSFKQII 257


>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
          Length = 800

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 78/274 (28%), Positives = 133/274 (48%), Gaps = 24/274 (8%)

Query: 10  GAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDN 69
           GA    +  ++L+  E  G G FG+V+RA+      +VAVK +    I +E + ++ L +
Sbjct: 5   GASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK--IEKEAEILSVLSH 62

Query: 70  EFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL--LCRLLKEVVLG 127
             +++  GVI      + P   +VT++   GSL   + S       +  +     +V  G
Sbjct: 63  RNIIQFYGVIL-----EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117

Query: 128 MFYLHDQNPV-LLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
           M YLH + PV ++HRDLK  NV++  +  +K+ DFG S F     + T      GT  ++
Sbjct: 118 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF----HNHTTHMSLVGTFPWM 173

Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELP 246
           APE+  ++    S   D YS+G+++W +L  REV       L    +   +N      +P
Sbjct: 174 APEVIQSL--PVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKN--ERLTIP 228

Query: 247 QAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL 280
            + P +       EL+  CW ++ K RPSF++ +
Sbjct: 229 SSCPRS-----FAELLHQCWEADAKKRPSFKQII 257


>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
           sapiens]
          Length = 986

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 85/288 (29%), Positives = 134/288 (46%), Gaps = 33/288 (11%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYD---VAVKIVNSKAISR-------EVKAMA 65
           + I  ++ ++++G G FG V     +  G     VA+K + S    +       E   M 
Sbjct: 616 IDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMG 675

Query: 66  SLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL-LCRLLKEV 124
             D+  V+ LEGV+ K          ++T+FMENGSL   L+    +   + L  +L+ +
Sbjct: 676 QFDHPNVIHLEGVVTK-----STPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGI 730

Query: 125 VLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF-QGGSQSGTGSGEPGG-- 181
             GM YL D N V  HRDL   N+L++  L  K++DFGLS F +  +   T +   GG  
Sbjct: 731 AAGMKYLADMNYV--HRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKI 788

Query: 182 TLGYLAPELFVNVNRKASTASDVYSFGILMWAVLA-GREVELPTEPSLVYEAVCNRQNRP 240
            + + APE      RK ++ASDV+S+GI+MW V++ G           V  A+      P
Sbjct: 789 PIRWTAPEAI--QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP 846

Query: 241 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
              + P A         L +LM  CW  +   RP F + +   D++ +
Sbjct: 847 PPMDCPSA---------LHQLMLDCWQKDRNHRPKFGQIVNTLDKMIR 885


>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
           sapiens]
          Length = 987

 Score = 96.7 bits (239), Expect = 5e-20
 Identities = 85/288 (29%), Positives = 134/288 (46%), Gaps = 33/288 (11%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYD---VAVKIVNSKAISR-------EVKAMA 65
           + I  ++ ++++G G FG V     +  G     VA+K + S    +       E   M 
Sbjct: 617 IDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMG 676

Query: 66  SLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL-LCRLLKEV 124
             D+  V+ LEGV+ K          ++T+FMENGSL   L+    +   + L  +L+ +
Sbjct: 677 QFDHPNVIHLEGVVTK-----STPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGI 731

Query: 125 VLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF-QGGSQSGTGSGEPGG-- 181
             GM YL D N V  HRDL   N+L++  L  K++DFGLS F +  +   T +   GG  
Sbjct: 732 AAGMKYLADMNYV--HRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKI 789

Query: 182 TLGYLAPELFVNVNRKASTASDVYSFGILMWAVLA-GREVELPTEPSLVYEAVCNRQNRP 240
            + + APE      RK ++ASDV+S+GI+MW V++ G           V  A+      P
Sbjct: 790 PIRWTAPEAI--QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP 847

Query: 241 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
              + P A         L +LM  CW  +   RP F + +   D++ +
Sbjct: 848 PPMDCPSA---------LHQLMLDCWQKDRNHRPKFGQIVNTLDKMIR 886


>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
           sapiens]
          Length = 859

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 78/273 (28%), Positives = 132/273 (48%), Gaps = 31/273 (11%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRL 75
           V  EE+ + + VG G  G VF  +    G +VAVK V       ++K +  L +  ++  
Sbjct: 120 VPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLK-ETDIKHLRKLKHPNIITF 176

Query: 76  EGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQN 135
           +GV       Q P   ++ +F   G L  +L++  P    LL      +  GM YLH   
Sbjct: 177 KGVCT-----QAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK 231

Query: 136 PVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVN 195
             ++HRDLK  N+L+  +  VK++DFG S       +        GT+ ++APE+  N  
Sbjct: 232 --IIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFA---GTVAWMAPEVIRN-- 284

Query: 196 RKASTASDVYSFGILMWAVLAGREVELPTEP----SLVYEAVCNRQNRPSLAELPQAGPE 251
              S   D++SFG+++W +L G   E+P +     ++++    N  + P  +  P     
Sbjct: 285 EPVSEKVDIWSFGVVLWELLTG---EIPYKDVDSSAIIWGVGSNSLHLPVPSSCP----- 336

Query: 252 TPGLEGLKELMQLCWSSEPKDRPSFQECLPKTD 284
               +G K L++ CW+S+P++RPSF++ L   D
Sbjct: 337 ----DGFKILLRQCWNSKPRNRPSFRQILLHLD 365


>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
           sapiens]
          Length = 648

 Score = 95.9 bits (237), Expect = 8e-20
 Identities = 81/269 (30%), Positives = 128/269 (47%), Gaps = 35/269 (13%)

Query: 27  VGKGGFGTVFRAQHRKWGYDVAVKIVNS--------KAISREVKAMASLDNEFVLRLEGV 78
           +G G FGTV++    KW  DVAVKI+          +A   EV  +    +  +L   G 
Sbjct: 355 IGSGSFGTVYKG---KWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 411

Query: 79  IEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL-LCRLLKEVVLGMFYLHDQNPV 137
           + K N       A+VT++ E  SL   L  Q  +     L  + ++   GM YLH +N  
Sbjct: 412 MTKDNL------AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN-- 463

Query: 138 LLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELF-VNVNR 196
           ++HRD+K +N+ L   L VK+ DFGL+T +          +P G++ ++APE+  +  N 
Sbjct: 464 IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNN 523

Query: 197 KASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGL- 255
             S  SDVYS+GI+++ ++ G   ELP      Y  + NR     +     A P+   L 
Sbjct: 524 PFSFQSDVYSYGIVLYELMTG---ELP------YSHINNRDQIIFMVGRGYASPDLSKLY 574

Query: 256 ----EGLKELMQLCWSSEPKDRPSFQECL 280
               + +K L+  C     ++RP F + L
Sbjct: 575 KNCPKAMKRLVADCVKKVKEERPLFPQIL 603


>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
          Length = 631

 Score = 95.1 bits (235), Expect = 1e-19
 Identities = 91/288 (31%), Positives = 136/288 (47%), Gaps = 37/288 (12%)

Query: 16  VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE-----VKAMASLDNE 70
           ++  EL     +G G FG V   + R   Y VA+K +   A+  E      K M  L + 
Sbjct: 365 INPSELTFMRELGSGLFGVVRLGKWRAQ-YKVAIKAIREGAMCEEDFIEEAKVMMKLTHP 423

Query: 71  FVLRLEGVIEKVNWDQDPKPA-LVTKFMENGSLSGLL-QSQCPRPWPLLCRLLKEVVLGM 128
            +++L GV  +       KP  +VT+FME G L   L Q Q      +L  + ++V  GM
Sbjct: 424 KLVQLYGVCTQ------QKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGM 477

Query: 129 FYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAP 188
            YL   +   +HRDL   N L+     VK++DFG++ +    Q  + SG     + +  P
Sbjct: 478 EYLERNS--FIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKF-PVKWCPP 534

Query: 189 ELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVC-----NRQNRPSLA 243
           E+F N +R  S+ SDV+SFG+LMW V    E  +P E    YE V      +R  +P LA
Sbjct: 535 EVF-NYSR-FSSKSDVWSFGVLMWEVFT--EGRMPFEKYTNYEVVTMVTRGHRLYQPKLA 590

Query: 244 ELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE 291
                         + E+M  CW  +P+ RPSF++ L   DE+ +  E
Sbjct: 591 S-----------NYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627


>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
          Length = 612

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 82/267 (30%), Positives = 129/267 (48%), Gaps = 30/267 (11%)

Query: 21  LENQELVGKGGFGTVFRA--QHRKWGYDVAVKIVNSKA--------ISREVKAMASLDNE 70
           LE++EL G G FGTV +   Q +K    VAVKI+ ++A        +  E   M  LDN 
Sbjct: 349 LEDKEL-GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 407

Query: 71  FVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFY 130
           +++R+ G+ E  +W       LV +  E G L+  LQ         +  L+ +V +GM Y
Sbjct: 408 YIVRMIGICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 461

Query: 131 LHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG-GTLGYLAPE 189
           L + N   +HRDL   NVLL  + + K++DFGLS      ++   +   G   + + APE
Sbjct: 462 LEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519

Query: 190 LFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAG 249
             +N   K S+ SDV+SFG+LMW   +  +          Y  +   +    L +  + G
Sbjct: 520 C-INY-YKFSSKSDVWSFGVLMWEAFSYGQKP--------YRGMKGSEVTAMLEKGERMG 569

Query: 250 PETPGLEGLKELMQLCWSSEPKDRPSF 276
                   + +LM LCW+ + ++RP F
Sbjct: 570 CPAGCPREMYDLMNLCWTYDVENRPGF 596


>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
          Length = 635

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 82/267 (30%), Positives = 129/267 (48%), Gaps = 30/267 (11%)

Query: 21  LENQELVGKGGFGTVFRA--QHRKWGYDVAVKIVNSKA--------ISREVKAMASLDNE 70
           LE++EL G G FGTV +   Q +K    VAVKI+ ++A        +  E   M  LDN 
Sbjct: 372 LEDKEL-GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 430

Query: 71  FVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFY 130
           +++R+ G+ E  +W       LV +  E G L+  LQ         +  L+ +V +GM Y
Sbjct: 431 YIVRMIGICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484

Query: 131 LHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG-GTLGYLAPE 189
           L + N   +HRDL   NVLL  + + K++DFGLS      ++   +   G   + + APE
Sbjct: 485 LEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542

Query: 190 LFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAG 249
             +N   K S+ SDV+SFG+LMW   +  +          Y  +   +    L +  + G
Sbjct: 543 C-INY-YKFSSKSDVWSFGVLMWEAFSYGQKP--------YRGMKGSEVTAMLEKGERMG 592

Query: 250 PETPGLEGLKELMQLCWSSEPKDRPSF 276
                   + +LM LCW+ + ++RP F
Sbjct: 593 CPAGCPREMYDLMNLCWTYDVENRPGF 619


>gi|148596974 TXK tyrosine kinase [Homo sapiens]
          Length = 527

 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 87/287 (30%), Positives = 137/287 (47%), Gaps = 43/287 (14%)

Query: 12  PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE-----VKAMAS 66
           P+ L  I+E      +G G FG V   + R     VA+K +N  ++S E      K M  
Sbjct: 268 PSELAFIKE------IGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMK 320

Query: 67  LDNEFVLRLEGVIEKVNWDQDPKPA-LVTKFMENGSLSGLLQSQCPR-PWPLLCRLLKEV 124
           L +  +++L GV  +       KP  +VT+FMENG L   L+    +    +L  + +++
Sbjct: 321 LSHSKLVQLYGVCIQ------RKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDI 374

Query: 125 VLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ--SGTGSGEPGGT 182
             GM YL       +HRDL   N L+     VK++DFG++ +    +  S  G+  P   
Sbjct: 375 CEGMEYLERNG--YIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFP--- 429

Query: 183 LGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSL-VYEAVCN--RQNR 239
           + +  PE+F+    K S+ SDV+SFG+LMW V    ++    + +L V EA+    R  R
Sbjct: 430 IKWSPPEVFLF--NKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYR 487

Query: 240 PSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEV 286
           P LA +            + E+M  CW  +P+ RP+F E L    E+
Sbjct: 488 PHLAPM-----------SIYEVMYSCWHEKPEGRPTFAELLRAVTEI 523


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.131    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,147,073
Number of Sequences: 37866
Number of extensions: 1414846
Number of successful extensions: 7728
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 590
Number of HSP's successfully gapped in prelim test: 357
Number of HSP's that attempted gapping in prelim test: 5177
Number of HSP's gapped (non-prelim): 1874
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


Home | Table of Contents | Search text | Search genes | Search sequences | Purchase | FAQ | Blog | Help

Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

CSHL Press