Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 40254844
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40254844 receptor-interacting serine-threonine kinase 3
[Homo sapiens]
(518 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo... 1070 0.0
gi|41327754 ankyrin repeat domain 3 [Homo sapiens] 151 1e-36
gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo ... 145 9e-35
gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinas... 141 1e-33
gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo ... 135 7e-32
gi|4501897 activin A receptor, type IIA precursor [Homo sapiens] 108 1e-23
gi|155723000 mixed lineage kinase 4 [Homo sapiens] 108 1e-23
gi|21735564 mitogen-activated protein kinase kinase kinase 7 iso... 107 3e-23
gi|21735562 mitogen-activated protein kinase kinase kinase 7 iso... 107 3e-23
gi|21735566 mitogen-activated protein kinase kinase kinase 7 iso... 105 8e-23
gi|4507361 mitogen-activated protein kinase kinase kinase 7 isof... 105 8e-23
gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens] 105 1e-22
gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens] 105 1e-22
gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Ho... 103 5e-22
gi|21735550 mitogen-activated protein kinase kinase kinase 10 [H... 102 6e-22
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens] 101 1e-21
gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Ho... 101 1e-21
gi|116734708 activin A receptor, type IIB precursor [Homo sapiens] 101 2e-21
gi|32967311 ephrin receptor EphA2 [Homo sapiens] 100 2e-21
gi|221316650 ephrin receptor EphA1 [Homo sapiens] 100 5e-21
gi|19526767 MLK-related kinase isoform 2 [Homo sapiens] 97 3e-20
gi|82880648 MLK-related kinase isoform 1 [Homo sapiens] 97 3e-20
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap... 97 5e-20
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi... 97 5e-20
gi|21735552 mitogen-activated protein kinase kinase kinase 12 [H... 96 8e-20
gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Hom... 96 8e-20
gi|130977759 tec protein tyrosine kinase [Homo sapiens] 95 1e-19
gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens] 94 2e-19
gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens] 94 2e-19
gi|148596974 TXK tyrosine kinase [Homo sapiens] 94 2e-19
>gi|40254844 receptor-interacting serine-threonine kinase 3 [Homo
sapiens]
Length = 518
Score = 1070 bits (2767), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 1 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE 60
MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE
Sbjct: 1 MSCVKLWPSGAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE 60
Query: 61 VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL 120
VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL
Sbjct: 61 VKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRL 120
Query: 121 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG 180
LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG
Sbjct: 121 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG 180
Query: 181 GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP 240
GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP
Sbjct: 181 GTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRP 240
Query: 241 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST 300
SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST
Sbjct: 241 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVST 300
Query: 301 VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS 360
VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS
Sbjct: 301 VKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEEPPSS 360
Query: 361 VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG 420
VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG
Sbjct: 361 VPKKCPSLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQMPSPTSTGTPSPG 420
Query: 421 PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA 480
PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA
Sbjct: 421 PRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQQTTALPTWGLA 480
Query: 481 PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK 518
PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK
Sbjct: 481 PSGKGRGLQHPPPVGSQEGPKDPEAWSRPQGWYNHSGK 518
>gi|41327754 ankyrin repeat domain 3 [Homo sapiens]
Length = 784
Score = 151 bits (382), Expect = 1e-36
Identities = 98/284 (34%), Positives = 144/284 (50%), Gaps = 19/284 (6%)
Query: 20 ELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAIS--------REVKAMASLDNEF 71
E E VG GGFG V++ +H W +A+K S + E K M +
Sbjct: 21 EFTGWEKVGSGGFGQVYKVRHVHWKTWLAIKCSPSLHVDDRERMELLEEAKKMEMAKFRY 80
Query: 72 VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYL 131
+L + G+ + LV ++ME GSL LL S+ P PW L R++ E +GM +L
Sbjct: 81 ILPVYGICRE-------PVGLVMEYMETGSLEKLLASE-PLPWDLRFRIIHETAVGMNFL 132
Query: 132 HDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEP-GGTLGYLAPEL 190
H P LLH DLKP+N+LLD HVK++DFGL+ G S S S + GT+ YL PE
Sbjct: 133 HCMAPPLLHLDLKPANILLDAHYHVKISDFGLAKCNGLSHSHDLSMDGLFGTIAYLPPER 192
Query: 191 FVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGP 250
+R T DVYSF I++W VL ++ + L + +RP L + +A P
Sbjct: 193 IREKSRLFDTKHDVYSFAIVIWGVLTQKKPFADEKNILHIMVKVVKGHRPELPPVCRARP 252
Query: 251 ETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNM 294
L LMQ CW +P+ RP+FQE +T+++ + ++ +
Sbjct: 253 R--ACSHLIRLMQRCWQGDPRVRPTFQEITSETEDLCEKPDDEV 294
>gi|4506537 receptor-interacting serine-threonine kinase 2 [Homo
sapiens]
Length = 540
Score = 145 bits (366), Expect = 9e-35
Identities = 99/297 (33%), Positives = 157/297 (52%), Gaps = 28/297 (9%)
Query: 14 PLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVN---------SKAISREVKAM 64
P + +L + + +G GTV A+H W VAVK ++ K + RE + +
Sbjct: 11 PTIPYHKLADLRYLSRGASGTVSSARHADWRVQVAVKHLHIHTPLLDSERKDVLREAEIL 70
Query: 65 ASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRP---WPLLCRLL 121
++L + G+ + + +VT++M NGSL+ LL + P WPL R+L
Sbjct: 71 HKARFSYILPILGICNEPEF-----LGIVTEYMPNGSLNELLHRKTEYPDVAWPLRFRIL 125
Query: 122 KEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQ--GGSQSGTGSGEP 179
E+ LG+ YLH+ P LLH DLK N+LLD E HVK+ADFGLS ++ SQS + P
Sbjct: 126 HEIALGVNYLHNMTPPLLHHDLKTQNILLDNEFHVKIADFGLSKWRMMSLSQSRSSKSAP 185
Query: 180 -GGTLGYLAPELF-VNVNRKASTASDVYSFGILMWAVLAGRE-VELPTEPSLVYEAVCNR 236
GGT+ Y+ PE + +AS D+YS+ ++ W VL+ ++ E T P + +V ++
Sbjct: 186 EGGTIIYMPPENYEPGQKSRASIKHDIYSYAVITWEVLSRKQPFEDVTNPLQIMYSV-SQ 244
Query: 237 QNRPSLAE--LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE 291
+RP + E LP + P + L++ W+ P +RPSF +CL + + V + E
Sbjct: 245 GHRPVINEESLPY---DIPHRARMISLIESGWAQNPDERPSFLKCLIELEPVLRTFE 298
>gi|57242761 receptor (TNFRSF)-interacting serine-threonine kinase 1
[Homo sapiens]
Length = 671
Score = 141 bits (356), Expect = 1e-33
Identities = 101/299 (33%), Positives = 160/299 (53%), Gaps = 53/299 (17%)
Query: 17 SIEELENQELVGKGGFGTVFRAQHRKWG-------YDVAVKIVNSKAISREVKAMASLDN 69
S + LE+ EL GGFG V HR G Y I +++A+ E K M L +
Sbjct: 14 SSDFLESAEL-DSGGFGKVSLCFHRTQGLMIMKTVYKGPNCIEHNEALLEEAKMMNRLRH 72
Query: 70 EFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMF 129
V++L GVI ++ K +LV ++ME G+L +L+++ P + R++ E++ GM
Sbjct: 73 SRVVKLLGVII-----EEGKYSLVMEYMEKGNLMHVLKAEMSTPLSVKGRIILEIIEGMC 127
Query: 130 YLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ------------SGTGSG 177
YLH + ++H+DLKP N+L+D + H+K+AD GL++F+ S+ GT
Sbjct: 128 YLHGKG--VIHKDLKPENILVDNDFHIKIADLGLASFKMWSKLNNEEHNELREVDGTAK- 184
Query: 178 EPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQ 237
+ GGTL Y+APE +VN K + SDVYSF +++WA+ A +E P E A+C +Q
Sbjct: 185 KNGGTLYYMAPEHLNDVNAKPTEKSDVYSFAVVLWAIFANKE---PYE-----NAICEQQ 236
Query: 238 --------NRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
NRP + ++ + P + LM+LCW + P+ RP+F P +E F+
Sbjct: 237 LIMCIKSGNRPDVDDITEYCPRE-----IISLMKLCWEANPEARPTF----PGIEEKFR 286
>gi|30425444 ankyrin repeat and kinase domain containing 1 [Homo
sapiens]
Length = 765
Score = 135 bits (341), Expect = 7e-32
Identities = 90/296 (30%), Positives = 144/296 (48%), Gaps = 28/296 (9%)
Query: 14 PLVSIEELENQ-ELVGKGGFGTVFRAQHRKWGYDVAVKIV----------NSKAISREVK 62
P+ + ++ E LV GGF VF+A+HR+W + A+K + + E
Sbjct: 14 PVFTRDDFEGDWRLVASGGFSQVFQARHRRWRTEYAIKCAPCLPPDAASSDVNYLIEEAA 73
Query: 63 AMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQ--SQCPRPWPLLCRL 120
M + + ++ + GV ++ +V +FM NGSL +L S C W L R+
Sbjct: 74 KMKKIKFQHIVSIYGVCKQ-------PLGIVMEFMANGSLEKVLSTHSLC---WKLRFRI 123
Query: 121 LKEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF--QGGSQSGTGSGE 178
+ E L M +LH P LLH DLKP N+LLD +HVK++DFGLS + Q
Sbjct: 124 IHETSLAMNFLHSIKPPLLHLDLKPGNILLDSNMHVKISDFGLSKWMEQSTRMQYIERSA 183
Query: 179 PGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQN 238
G L Y+ PE+F+ N+ DVYSF I++W +L ++ ++ V
Sbjct: 184 LRGMLSYIPPEMFLESNKAPGPKYDVYSFAIVIWELLTQKKPYSGFNMMMIIIRVAAGM- 242
Query: 239 RPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNM 294
RPSL + P + + +LM+ CW +PK RP F + +TD + ++++ +
Sbjct: 243 RPSLQPVSDQWPSE--AQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLLQSRV 296
>gi|4501897 activin A receptor, type IIA precursor [Homo sapiens]
Length = 513
Score = 108 bits (270), Expect = 1e-23
Identities = 94/298 (31%), Positives = 144/298 (48%), Gaps = 43/298 (14%)
Query: 12 PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIV-----NSKAISREVKAMAS 66
P+PL+ ++ L+ E+ +G FG V++AQ VAVKI S EV ++
Sbjct: 183 PSPLLGLKPLQLLEVKARGRFGCVWKAQ--LLNEYVAVKIFPIQDKQSWQNEYEVYSLPG 240
Query: 67 LDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVL 126
+ +E +L+ G EK D L+T F E GSLS L++ W LC + + +
Sbjct: 241 MKHENILQFIGA-EKRGTSVDVDLWLITAFHEKGSLSDFLKANVVS-WNELCHIAETMAR 298
Query: 127 GMFYLHDQ--------NPVLLHRDLKPSNVLLDPELHVKLADFGLS-TFQGGSQSGTGSG 177
G+ YLH+ P + HRD+K NVLL L +ADFGL+ F+ G +G G
Sbjct: 299 GLAYLHEDIPGLKDGHKPAISHRDIKSKNVLLKNNLTACIADFGLALKFEAGKSAGDTHG 358
Query: 178 EPGGTLGYLAPELF---VNVNRKASTASDVYSFGILMWAVLAGR---------------E 219
+ GT Y+APE+ +N R A D+Y+ G+++W LA R E
Sbjct: 359 QV-GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWE-LASRCTAADGPVDEYMLPFE 416
Query: 220 VELPTEPSL--VYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPS 275
E+ PSL + E V +++ RP L + Q + G+ L E ++ CW + + R S
Sbjct: 417 EEIGQHPSLEDMQEVVVHKKKRPVLRDYWQ---KHAGMAMLCETIEECWDHDAEARLS 471
>gi|155723000 mixed lineage kinase 4 [Homo sapiens]
Length = 1036
Score = 108 bits (270), Expect = 1e-23
Identities = 131/494 (26%), Positives = 204/494 (41%), Gaps = 94/494 (19%)
Query: 8 PSGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVN----------SKA 56
PS +P+ V+ E LE +EL+G GGFG V+RA + G +VAVK +++
Sbjct: 110 PSRPSSPVHVAFERLELKELIGAGGFGQVYRATWQ--GQEVAVKAARQDPEQDAAAAAES 167
Query: 57 ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWP- 115
+ RE + A L + ++ L GV Q P LV +F G+L+ L + P P
Sbjct: 168 VRREARLFAMLRHPNIIELRGVCL-----QQPHLCLVLEFARGGALNRALAAANAAPDPR 222
Query: 116 -------------LLCRLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLLDPELH------ 155
+L ++ GM YLH++ V +LHRDLK SN+LL ++
Sbjct: 223 APGPRRARRIPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEKIEHDDICN 282
Query: 156 --VKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWA 213
+K+ DFGL+ T GT ++APE V + S SD++S+G+L+W
Sbjct: 283 KTLKITDFGLAR----EWHRTTKMSTAGTYAWMAPE--VIKSSLFSKGSDIWSYGVLLWE 336
Query: 214 VLAGREVELPTEP----SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSE 269
+L G E+P ++ Y N+ P +P PE +LM+ CW +
Sbjct: 337 LLTG---EVPYRGIDGLAVAYGVAVNKLTLP----IPSTCPEP-----FAKLMKECWQQD 384
Query: 270 PKDRPSFQECLPK------------TDEVFQMVENNMNAAVSTVKDFL----SQLRSSNR 313
P RPSF L + E F ++++ + + D L +LRS
Sbjct: 385 PHIRPSFALILEQLTAIEGAVMTEMPQESFHSMQDDWKLEIQQMFDELRTKEKELRSREE 444
Query: 314 RFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSE---WLNKLNLEEPPSSVPKKCPSLTK 370
+ Q E RR + DV+ E + +LN E+P KK K
Sbjct: 445 ELTRAALQQKSQEELLKRREQQLAEREIDVLERELNILIFQLNQEKPK---VKKRKGKFK 501
Query: 371 RSRAQEEQVPQAWTAGTSSD-----SMAQPPQTPETSTFRNQMPSPTSTGTPSPGPRGNQ 425
RSR ++ SD ++ P + + + SP S+ T P R Q
Sbjct: 502 RSRL---KLKDGHRISLPSDFQHKITVQASPNLDKRRSLNSSSSSPPSSPTMMPRLRAIQ 558
Query: 426 -GAERQGMNWSCRT 438
++ W T
Sbjct: 559 LTSDESNKTWGRNT 572
>gi|21735564 mitogen-activated protein kinase kinase kinase 7
isoform C [Homo sapiens]
Length = 518
Score = 107 bits (267), Expect = 3e-23
Identities = 128/475 (26%), Positives = 203/475 (42%), Gaps = 69/475 (14%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS----KAISREVKAMASLDNEF 71
+ +E+E +E+VG+G FG V +A+ R DVA+K + S KA E++ ++ +++
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVNHPN 88
Query: 72 VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLK---EVVLGM 128
+++L G LV ++ E GSL +L P P+ + + G+
Sbjct: 89 IVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141
Query: 129 FYLHDQNP-VLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
YLH P L+HRDLKP N+LL V K+ DFG + T G+ ++
Sbjct: 142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTHMTNNKGSAAWM 196
Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREV--ELPTEPSLVYEAVCNRQNRPSLAE 244
APE+F N S DV+S+GI++W V+ R+ E+ + AV N P +
Sbjct: 197 APEVFEGSNY--SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN 254
Query: 245 LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL----------PKTDEVFQMV---- 290
LP+ ++ LM CWS +P RPS +E + P DE Q
Sbjct: 255 LPKP---------IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYS 305
Query: 291 -ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWL 349
E N+A ST F+ ++ S Q D +R +E++ +N
Sbjct: 306 DEGQSNSATST-GSFMDIASTNTSNKSDTNMEQVPATNDTIKR-LESKLLKNQAKQQSES 363
Query: 350 NKLNLEEPPSSVPKKCP--SLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRN- 406
+L+L S + P S KR A ++ +A A T++ S + +T++F N
Sbjct: 364 GRLSLGASRGSSVESLPPTSEGKRMSADMSEI-EARIAATTAYSKPKRGHR-KTASFGNI 421
Query: 407 -QMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGR---PLVNIYNCSG 457
+P +G P R Q G EP V+ R P V + SG
Sbjct: 422 LDVPEIVISGNGQPRRRSIQDLTVTG-------TEPGQVSSRSSSPSVRMITTSG 469
>gi|21735562 mitogen-activated protein kinase kinase kinase 7
isoform B [Homo sapiens]
Length = 606
Score = 107 bits (267), Expect = 3e-23
Identities = 128/475 (26%), Positives = 203/475 (42%), Gaps = 69/475 (14%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS----KAISREVKAMASLDNEF 71
+ +E+E +E+VG+G FG V +A+ R DVA+K + S KA E++ ++ +++
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVNHPN 88
Query: 72 VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLK---EVVLGM 128
+++L G LV ++ E GSL +L P P+ + + G+
Sbjct: 89 IVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141
Query: 129 FYLHDQNP-VLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
YLH P L+HRDLKP N+LL V K+ DFG + T G+ ++
Sbjct: 142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTHMTNNKGSAAWM 196
Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREV--ELPTEPSLVYEAVCNRQNRPSLAE 244
APE+F N S DV+S+GI++W V+ R+ E+ + AV N P +
Sbjct: 197 APEVFEGSNY--SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN 254
Query: 245 LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL----------PKTDEVFQMV---- 290
LP+ ++ LM CWS +P RPS +E + P DE Q
Sbjct: 255 LPKP---------IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYS 305
Query: 291 -ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWL 349
E N+A ST F+ ++ S Q D +R +E++ +N
Sbjct: 306 DEGQSNSATST-GSFMDIASTNTSNKSDTNMEQVPATNDTIKR-LESKLLKNQAKQQSES 363
Query: 350 NKLNLEEPPSSVPKKCP--SLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRN- 406
+L+L S + P S KR A ++ +A A T++ S + +T++F N
Sbjct: 364 GRLSLGASRGSSVESLPPTSEGKRMSADMSEI-EARIAATTAYSKPKRGHR-KTASFGNI 421
Query: 407 -QMPSPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGR---PLVNIYNCSG 457
+P +G P R Q G EP V+ R P V + SG
Sbjct: 422 LDVPEIVISGNGQPRRRSIQDLTVTG-------TEPGQVSSRSSSPSVRMITTSG 469
>gi|21735566 mitogen-activated protein kinase kinase kinase 7
isoform D [Homo sapiens]
Length = 491
Score = 105 bits (263), Expect = 8e-23
Identities = 116/435 (26%), Positives = 189/435 (43%), Gaps = 57/435 (13%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS----KAISREVKAMASLDNEF 71
+ +E+E +E+VG+G FG V +A+ R DVA+K + S KA E++ ++ +++
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVNHPN 88
Query: 72 VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLK---EVVLGM 128
+++L G LV ++ E GSL +L P P+ + + G+
Sbjct: 89 IVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141
Query: 129 FYLHDQNP-VLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
YLH P L+HRDLKP N+LL V K+ DFG + T G+ ++
Sbjct: 142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTHMTNNKGSAAWM 196
Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREV--ELPTEPSLVYEAVCNRQNRPSLAE 244
APE+F N S DV+S+GI++W V+ R+ E+ + AV N P +
Sbjct: 197 APEVFEGSNY--SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN 254
Query: 245 LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL----------PKTDEVFQMV---- 290
LP+ ++ LM CWS +P RPS +E + P DE Q
Sbjct: 255 LPKP---------IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYS 305
Query: 291 -ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWL 349
E N+A ST F+ ++ S Q D +R +E++ +N
Sbjct: 306 DEGQSNSATST-GSFMDIASTNTSNKSDTNMEQVPATNDTIKR-LESKLLKNQAKQQSES 363
Query: 350 NKLNLEEPPSSVPKKCP--SLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQ 407
+L+L S + P S KR A ++ +A A T+ + + ++ + T
Sbjct: 364 GRLSLGASRGSSVESLPPTSEGKRMSADMSEI-EARIAATTGNGQPR-RRSIQDLTVTGT 421
Query: 408 MPSPTSTGTPSPGPR 422
P S+ + SP R
Sbjct: 422 EPGQVSSRSSSPSVR 436
>gi|4507361 mitogen-activated protein kinase kinase kinase 7 isoform
A [Homo sapiens]
Length = 579
Score = 105 bits (263), Expect = 8e-23
Identities = 116/435 (26%), Positives = 189/435 (43%), Gaps = 57/435 (13%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNS----KAISREVKAMASLDNEF 71
+ +E+E +E+VG+G FG V +A+ R DVA+K + S KA E++ ++ +++
Sbjct: 31 IDYKEIEVEEVVGRGAFGVVCKAKWR--AKDVAIKQIESESERKAFIVELRQLSRVNHPN 88
Query: 72 VLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLK---EVVLGM 128
+++L G LV ++ E GSL +L P P+ + + G+
Sbjct: 89 IVKLYGACLN-------PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGV 141
Query: 129 FYLHDQNP-VLLHRDLKPSNVLLDPELHV-KLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
YLH P L+HRDLKP N+LL V K+ DFG + T G+ ++
Sbjct: 142 AYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC-----DIQTHMTNNKGSAAWM 196
Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREV--ELPTEPSLVYEAVCNRQNRPSLAE 244
APE+F N S DV+S+GI++W V+ R+ E+ + AV N P +
Sbjct: 197 APEVFEGSNY--SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN 254
Query: 245 LPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL----------PKTDEVFQMV---- 290
LP+ ++ LM CWS +P RPS +E + P DE Q
Sbjct: 255 LPKP---------IESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYS 305
Query: 291 -ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWL 349
E N+A ST F+ ++ S Q D +R +E++ +N
Sbjct: 306 DEGQSNSATST-GSFMDIASTNTSNKSDTNMEQVPATNDTIKR-LESKLLKNQAKQQSES 363
Query: 350 NKLNLEEPPSSVPKKCP--SLTKRSRAQEEQVPQAWTAGTSSDSMAQPPQTPETSTFRNQ 407
+L+L S + P S KR A ++ +A A T+ + + ++ + T
Sbjct: 364 GRLSLGASRGSSVESLPPTSEGKRMSADMSEI-EARIAATTGNGQPR-RRSIQDLTVTGT 421
Query: 408 MPSPTSTGTPSPGPR 422
P S+ + SP R
Sbjct: 422 EPGQVSSRSSSPSVR 436
>gi|7705748 TNNI3 interacting kinase isoform b [Homo sapiens]
Length = 835
Score = 105 bits (261), Expect = 1e-22
Identities = 97/351 (27%), Positives = 159/351 (45%), Gaps = 34/351 (9%)
Query: 4 VKLWPSGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKA------ 56
+ L +G P+ + + E+E E++G G FG V++ + R VA+K +
Sbjct: 445 ILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSD 502
Query: 57 ---ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKP-ALVTKFMENGSLSGLLQSQCPR 112
REV + L++ V++ G DP A+VT+++ GSL LL Q R
Sbjct: 503 VDMFCREVSILCQLNHPCVIQFVGACLN-----DPSQFAIVTQYISGGSLFSLLHEQ-KR 556
Query: 113 PWPLLCRLL--KEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGS 170
L +L+ +V GM YLH+ ++HRDL N+LL + H +ADFG S F
Sbjct: 557 ILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL 616
Query: 171 QSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVY 230
+ +P G L ++APE+F R A DV+S+ + +W +L G +P+
Sbjct: 617 DEDNMTKQP-GNLRWMAPEVFTQCTRYTIKA-DVFSYALCLWEILTGEIPFAHLKPAAAA 674
Query: 231 EAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMV 290
+ RP + G P + + L+ W++ P+ RP F E + K +E +
Sbjct: 675 ADMAYHHIRPPI------GYSIP--KPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNI 726
Query: 291 ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRN 341
E M+ A S LS SS+ + G G + + R E +++ N
Sbjct: 727 E-LMSPASSNSSGSLSP--SSSSDCLVNRGGPGRSHVAALRSRFELEYALN 774
>gi|163914396 TNNI3 interacting kinase isoform a [Homo sapiens]
Length = 936
Score = 105 bits (261), Expect = 1e-22
Identities = 97/351 (27%), Positives = 159/351 (45%), Gaps = 34/351 (9%)
Query: 4 VKLWPSGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKA------ 56
+ L +G P+ + + E+E E++G G FG V++ + R VA+K +
Sbjct: 546 ILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRN--KIVAIKRYRANTYCSKSD 603
Query: 57 ---ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKP-ALVTKFMENGSLSGLLQSQCPR 112
REV + L++ V++ G DP A+VT+++ GSL LL Q R
Sbjct: 604 VDMFCREVSILCQLNHPCVIQFVGACLN-----DPSQFAIVTQYISGGSLFSLLHEQ-KR 657
Query: 113 PWPLLCRLL--KEVVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGS 170
L +L+ +V GM YLH+ ++HRDL N+LL + H +ADFG S F
Sbjct: 658 ILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSL 717
Query: 171 QSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVY 230
+ +P G L ++APE+F R A DV+S+ + +W +L G +P+
Sbjct: 718 DEDNMTKQP-GNLRWMAPEVFTQCTRYTIKA-DVFSYALCLWEILTGEIPFAHLKPAAAA 775
Query: 231 EAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMV 290
+ RP + G P + + L+ W++ P+ RP F E + K +E +
Sbjct: 776 ADMAYHHIRPPI------GYSIP--KPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNI 827
Query: 291 ENNMNAAVSTVKDFLSQLRSSNRRFSIPESGQGGTEMDGFRRTIENQHSRN 341
E M+ A S LS SS+ + G G + + R E +++ N
Sbjct: 828 E-LMSPASSNSSGSLSP--SSSSDCLVNRGGPGRSHVAALRSRFELEYALN 875
>gi|52421790 mitogen-activated protein kinase kinase kinase 9 [Homo
sapiens]
Length = 1118
Score = 103 bits (256), Expect = 5e-22
Identities = 96/337 (28%), Positives = 156/337 (46%), Gaps = 62/337 (18%)
Query: 12 PAPLVSIE--ELENQELVGKGGFGTVFRAQHRKW-GYDVAVKIVNS----------KAIS 58
P L+ I+ EL +E++G GGFG V+RA W G +VAVK + +
Sbjct: 133 PIQLLEIDFAELTLEEIIGIGGFGKVYRAF---WIGDEVAVKAARHDPDEDISQTIENVR 189
Query: 59 REVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLC 118
+E K A L + ++ L GV K +P LV +F G L+ +L + P +L
Sbjct: 190 QEAKLFAMLKHPNIIALRGVCLK-----EPNLCLVMEFARGGPLNRVLSGKRIPP-DILV 243
Query: 119 RLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLLDPELH--------VKLADFGLSTFQGG 169
++ GM YLHD+ V ++HRDLK SN+L+ ++ +K+ DFGL+
Sbjct: 244 NWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVENGDLSNKILKITDFGLAR---- 299
Query: 170 SQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEP--- 226
T GT ++APE+ S SDV+S+G+L+W +L G E+P
Sbjct: 300 EWHRTTKMSAAGTYAWMAPEVIRA--SMFSKGSDVWSYGVLLWELLTG---EVPFRGIDG 354
Query: 227 -SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE 285
++ Y N+ P +P PE +LM+ CW+ +P RPSF L +
Sbjct: 355 LAVAYGVAMNKLALP----IPSTCPEP-----FAKLMEDCWNPDPHSRPSFTNILDQLTT 405
Query: 286 V-----FQMVENNMNAAVST----VKDFLSQLRSSNR 313
+ F+M +++ + +++ QLR+ +
Sbjct: 406 IEESGFFEMPKDSFHCLQDNWKHEIQEMFDQLRAKEK 442
>gi|21735550 mitogen-activated protein kinase kinase kinase 10 [Homo
sapiens]
Length = 954
Score = 102 bits (255), Expect = 6e-22
Identities = 88/305 (28%), Positives = 144/305 (47%), Gaps = 50/305 (16%)
Query: 8 PSGAPAPL-VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVK----------IVNSKA 56
P+G P + EL+ +E++G GGFG V+RA R G +VAVK V ++
Sbjct: 84 PAGLQLPQEIPFHELQLEEIIGVGGFGKVYRALWR--GEEVAVKAARLDPEKDPAVTAEQ 141
Query: 57 ISREVKAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL 116
+ +E + +L + ++ L G P LV ++ G+LS +L + P +
Sbjct: 142 VCQEARLFGALQHPNIIALRGACL-----NPPHLCLVMEYARGGALSRVLAGRRVPP-HV 195
Query: 117 LCRLLKEVVLGMFYLHDQNPV-LLHRDLKPSNVLLDPELH--------VKLADFGLSTFQ 167
L +V GM YLH+ PV ++HRDLK N+L+ + +K+ DFGL+
Sbjct: 196 LVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAR-- 253
Query: 168 GGSQSGTGSGEPGGTLGYLAPELFVNVNRKASTASDVYSFGILMWAVLAG----REVELP 223
T GT ++APE+ + ++ S +SDV+SFG+L+W +L G RE++
Sbjct: 254 --EWHKTTKMSAAGTYAWMAPEV-IRLS-LFSKSSDVWSFGVLLWELLTGEVPYREID-- 307
Query: 224 TEPSLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKT 283
++ Y N+ P +P PE L++ CW +P RP F L +
Sbjct: 308 -ALAVAYGVAMNKLTLP----IPSTCPEP-----FARLLEECWDPDPHGRPDFGSILKRL 357
Query: 284 DEVFQ 288
+ + Q
Sbjct: 358 EVIEQ 362
>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
Length = 984
Score = 101 bits (252), Expect = 1e-21
Identities = 84/289 (29%), Positives = 140/289 (48%), Gaps = 35/289 (12%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYD---VAVKIVNS-------KAISREVKAMA 65
+ + ++ +E++G G FG V++ + + G VA+K + + + E M
Sbjct: 614 IDVSFVKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMG 673
Query: 66 SLDNEFVLRLEGVIEKVNWDQDPKPALV-TKFMENGSLSGLLQSQCPRPWPL-LCRLLKE 123
D+ ++RLEGV+ K +P ++ T+FMENG+L L+ + + L +L+
Sbjct: 674 QFDHPNIIRLEGVVTK------SRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRG 727
Query: 124 VVLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF-QGGSQSGTGSGEPGGT 182
+ GM YL + N V HRDL N+L++ L K++DFGLS + Q + T + GG
Sbjct: 728 IAAGMKYLAEMNYV--HRDLAARNILVNSNLVCKVSDFGLSRYLQDDTSDPTYTSSLGGK 785
Query: 183 L--GYLAPELFVNVNRKASTASDVYSFGILMWAVLA-GREVELPTEPSLVYEAVCNRQNR 239
+ + APE RK ++ASDV+S+GI+MW V++ G V A+
Sbjct: 786 IPVRWTAPEAI--AYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRL 843
Query: 240 PSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
P + P A L +LM CW + RP F E + D++ +
Sbjct: 844 PPPMDCPAA---------LHQLMLDCWQKDRNSRPRFAEIVNTLDKMIR 883
>gi|4505195 mitogen-activated protein kinase kinase kinase 11 [Homo
sapiens]
Length = 847
Score = 101 bits (252), Expect = 1e-21
Identities = 93/309 (30%), Positives = 143/309 (46%), Gaps = 55/309 (17%)
Query: 12 PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKI----------VNSKAISREV 61
P + S +EL +E++G GGFG V+R R G VAVK V ++++ +E
Sbjct: 108 PCEVASFQELRLEEVIGIGGFGKVYRGSWR--GELVAVKAARQDPDEDISVTAESVRQEA 165
Query: 62 KAMASLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLL 121
+ A L + ++ L+ V ++P LV ++ G LS L + P +L
Sbjct: 166 RLFAMLAHPNIIALKAVCL-----EEPNLCLVMEYAAGGPLSRALAGRRVPP-HVLVNWA 219
Query: 122 KEVVLGMFYLHDQNPV-LLHRDLKPSNVLL------DPELH--VKLADFGLSTFQGGSQS 172
++ GM YLH + V ++HRDLK +N+LL D H +K+ DFGL+
Sbjct: 220 VQIARGMHYLHCEALVPVIHRDLKSNNILLLQPIESDDMEHKTLKITDFGLAR----EWH 275
Query: 173 GTGSGEPGGTLGYLAPELFVNVNRKAST---ASDVYSFGILMWAVLAGREVELPTEP--- 226
T GT ++APE+ KAST SDV+SFG+L+W +L G E+P
Sbjct: 276 KTTQMSAAGTYAWMAPEVI-----KASTFSKGSDVWSFGVLLWELLTG---EVPYRGIDC 327
Query: 227 -SLVYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDE 285
++ Y N+ P +P PE +LM CW+ +P RP F L + +
Sbjct: 328 LAVAYGVAVNKLTLP----IPSTCPEP-----FAQLMADCWAQDPHRRPDFASILQQLEA 378
Query: 286 VFQMVENNM 294
+ V M
Sbjct: 379 LEAQVLREM 387
Score = 36.2 bits (82), Expect = 0.074
Identities = 42/170 (24%), Positives = 67/170 (39%), Gaps = 17/170 (10%)
Query: 352 LNLEEPPSSVPKKCPSLTKRSRAQEEQVPQ--AWTAGTSSDSMAQPPQTPETSTFRNQMP 409
L EEP VP + S + + + + + A A QPP P R +
Sbjct: 618 LEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGPG----RERGE 673
Query: 410 SPTSTGTPSPGPRGNQGAERQGMNWSCRTPEPNPVTGRPLVNIYNCSGVQVGDNNYLTMQ 469
SPT+ TP+P P + + +S +TP+ P L+++ G+ VG + + +
Sbjct: 674 SPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDL----GIPVGQRSAKSPR 729
Query: 470 QT------TALPTWGLAPSGKGR-GLQHPPPVGSQEGPKDPEAWSRPQGW 512
+ T P G + S G G PP+G P+ SR W
Sbjct: 730 REEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPW 779
>gi|116734708 activin A receptor, type IIB precursor [Homo sapiens]
Length = 512
Score = 101 bits (251), Expect = 2e-21
Identities = 97/341 (28%), Positives = 160/341 (46%), Gaps = 49/341 (14%)
Query: 12 PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIV-----NSKAISREVKAMAS 66
P+PLV ++ L+ E+ +G FG V++AQ VAVKI S RE+ +
Sbjct: 181 PSPLVGLKPLQLLEIKARGRFGCVWKAQ--LMNDFVAVKIFPLQDKQSWQSEREIFSTPG 238
Query: 67 LDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVL 126
+ +E +L+ EK + + + L+T F + GSL+ L+ W LC + + +
Sbjct: 239 MKHENLLQFIAA-EKRGSNLEVELWLITAFHDKGSLTDYLKGNIIT-WNELCHVAETMSR 296
Query: 127 GMFYLHDQ---------NPVLLHRDLKPSNVLLDPELHVKLADFGLST-FQGGSQSGTGS 176
G+ YLH+ P + HRD K NVLL +L LADFGL+ F+ G G
Sbjct: 297 GLSYLHEDVPWCRGEGHKPSIAHRDFKSKNVLLKSDLTAVLADFGLAVRFEPGKPPGDTH 356
Query: 177 GEPGGTLGYLAPELF---VNVNRKASTASDVYSFGILMWAVLA--------------GRE 219
G+ GT Y+APE+ +N R A D+Y+ G+++W +++ E
Sbjct: 357 GQV-GTRRYMAPEVLEGAINFQRDAFLRIDMYAMGLVLWELVSRCKAADGPVDEYMLPFE 415
Query: 220 VELPTEPSL--VYEAVCNRQNRPSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQ 277
E+ PSL + E V +++ RP++ + + PGL L ++ CW + + R S
Sbjct: 416 EEIGQHPSLEELQEVVVHKKMRPTIKD---HWLKHPGLAQLCVTIEECWDHDAEARLS-A 471
Query: 278 ECLPKTDEVFQMVENNMNAAVSTVKDFLSQLRSSNRRFSIP 318
C+ +E ++ ++N T D L L +S +P
Sbjct: 472 GCV---EERVSLIRRSVN---GTTSDCLVSLVTSVTNVDLP 506
>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
Length = 976
Score = 100 bits (250), Expect = 2e-21
Identities = 98/348 (28%), Positives = 153/348 (43%), Gaps = 58/348 (16%)
Query: 24 QELVGKGGFGTVFRAQHR----KWGYDVAVKIVNSKAISR-------EVKAMASLDNEFV 72
Q+++G G FG V++ + K VA+K + + + E M + +
Sbjct: 616 QKVIGAGEFGEVYKGMLKTSSGKKEVPVAIKTLKAGYTEKQRVDFLGEAGIMGQFSHHNI 675
Query: 73 LRLEGVIEKVNWDQDPKPALV-TKFMENGSLSGLLQSQCPRPWPL-LCRLLKEVVLGMFY 130
+RLEGVI K KP ++ T++MENG+L L+ + L L +L+ + GM Y
Sbjct: 676 IRLEGVISKY------KPMMIITEYMENGALDKFLREKDGEFSVLQLVGMLRGIAAGMKY 729
Query: 131 LHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGT-LGYLAPE 189
L + N V HRDL N+L++ L K++DFGLS T + G + + APE
Sbjct: 730 LANMNYV--HRDLAARNILVNSNLVCKVSDFGLSRVLEDDPEATYTTSGGKIPIRWTAPE 787
Query: 190 LFVNVNRKASTASDVYSFGILMWAVLA-GREVELPTEPSLVYEAVCNRQNRPSLAELPQA 248
RK ++ASDV+SFGI+MW V+ G V +A+ + P+ + P A
Sbjct: 788 AISY--RKFTSASDVWSFGIVMWEVMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSA 845
Query: 249 GPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVENNMNAAVSTVKDFLSQL 308
+ +LM CW E RP F + + D++ + D L L
Sbjct: 846 ---------IYQLMMQCWQQERARRPKFADIVSILDKLIR------------APDSLKTL 884
Query: 309 RSSNRRFSIPESGQGGTEMDGFRRTIENQHSRNDVMVSEWLNKLNLEE 356
+ R SI G+E FR VSEWL + +++
Sbjct: 885 ADFDPRVSIRLPSTSGSEGVPFR------------TVSEWLESIKMQQ 920
>gi|221316650 ephrin receptor EphA1 [Homo sapiens]
Length = 976
Score = 99.8 bits (247), Expect = 5e-21
Identities = 85/268 (31%), Positives = 131/268 (48%), Gaps = 36/268 (13%)
Query: 26 LVGKGGFGTVFRAQHRKWGYD---VAVKIVNSKA-------ISREVKAMASLDNEFVLRL 75
++G+G FG V+R R D VA+K + + RE M + +L L
Sbjct: 629 VIGEGEFGEVYRGTLRLPSQDCKTVAIKTLKDTSPGGQWWNFLREATIMGQFSHPHILHL 688
Query: 76 EGVIEKVNWDQDPKPALV-TKFMENGSLSGLLQSQCPRPWP-LLCRLLKEVVLGMFYLHD 133
EGV+ K KP ++ T+FMENG+L L+ + + P L +L+ + GM YL +
Sbjct: 689 EGVVTK------RKPIMIITEFMENGALDAFLREREDQLVPGQLVAMLQGIASGMNYLSN 742
Query: 134 QNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQG---GSQSGTGSGEPGGTLGYLAPEL 190
N V HRDL N+L++ L K++DFGL+ G+ G P + + APE
Sbjct: 743 HNYV--HRDLAARNILVNQNLCCKVSDFGLTRLLDDFDGTYETQGGKIP---IRWTAPEA 797
Query: 191 FVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGP 250
+ R +TASDV+SFGI+MW VL+ + Y + N++ S+ + + P
Sbjct: 798 IAH--RIFTTASDVWSFGIVMWEVLSFGDKP--------YGEMSNQEVMKSIEDGYRLPP 847
Query: 251 ETPGLEGLKELMQLCWSSEPKDRPSFQE 278
L ELM+ CW+ + RP FQ+
Sbjct: 848 PVDCPAPLYELMKNCWAYDRARRPHFQK 875
>gi|19526767 MLK-related kinase isoform 2 [Homo sapiens]
Length = 455
Score = 97.4 bits (241), Expect = 3e-20
Identities = 78/274 (28%), Positives = 133/274 (48%), Gaps = 24/274 (8%)
Query: 10 GAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDN 69
GA + ++L+ E G G FG+V+RA+ +VAVK + I +E + ++ L +
Sbjct: 5 GASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK--IEKEAEILSVLSH 62
Query: 70 EFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL--LCRLLKEVVLG 127
+++ GVI + P +VT++ GSL + S + + +V G
Sbjct: 63 RNIIQFYGVIL-----EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117
Query: 128 MFYLHDQNPV-LLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
M YLH + PV ++HRDLK NV++ + +K+ DFG S F + T GT ++
Sbjct: 118 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF----HNHTTHMSLVGTFPWM 173
Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELP 246
APE+ ++ S D YS+G+++W +L REV L + +N +P
Sbjct: 174 APEVIQSL--PVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKN--ERLTIP 228
Query: 247 QAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL 280
+ P + EL+ CW ++ K RPSF++ +
Sbjct: 229 SSCPRS-----FAELLHQCWEADAKKRPSFKQII 257
>gi|82880648 MLK-related kinase isoform 1 [Homo sapiens]
Length = 800
Score = 97.4 bits (241), Expect = 3e-20
Identities = 78/274 (28%), Positives = 133/274 (48%), Gaps = 24/274 (8%)
Query: 10 GAPAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDN 69
GA + ++L+ E G G FG+V+RA+ +VAVK + I +E + ++ L +
Sbjct: 5 GASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLK--IEKEAEILSVLSH 62
Query: 70 EFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL--LCRLLKEVVLG 127
+++ GVI + P +VT++ GSL + S + + +V G
Sbjct: 63 RNIIQFYGVIL-----EPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKG 117
Query: 128 MFYLHDQNPV-LLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYL 186
M YLH + PV ++HRDLK NV++ + +K+ DFG S F + T GT ++
Sbjct: 118 MHYLHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRF----HNHTTHMSLVGTFPWM 173
Query: 187 APELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELP 246
APE+ ++ S D YS+G+++W +L REV L + +N +P
Sbjct: 174 APEVIQSL--PVSETCDTYSYGVVLWEMLT-REVPFKGLEGLQVAWLVVEKN--ERLTIP 228
Query: 247 QAGPETPGLEGLKELMQLCWSSEPKDRPSFQECL 280
+ P + EL+ CW ++ K RPSF++ +
Sbjct: 229 SSCPRS-----FAELLHQCWEADAKKRPSFKQII 257
>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
sapiens]
Length = 986
Score = 96.7 bits (239), Expect = 5e-20
Identities = 85/288 (29%), Positives = 134/288 (46%), Gaps = 33/288 (11%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYD---VAVKIVNSKAISR-------EVKAMA 65
+ I ++ ++++G G FG V + G VA+K + S + E M
Sbjct: 616 IDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMG 675
Query: 66 SLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL-LCRLLKEV 124
D+ V+ LEGV+ K ++T+FMENGSL L+ + + L +L+ +
Sbjct: 676 QFDHPNVIHLEGVVTK-----STPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGI 730
Query: 125 VLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF-QGGSQSGTGSGEPGG-- 181
GM YL D N V HRDL N+L++ L K++DFGLS F + + T + GG
Sbjct: 731 AAGMKYLADMNYV--HRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKI 788
Query: 182 TLGYLAPELFVNVNRKASTASDVYSFGILMWAVLA-GREVELPTEPSLVYEAVCNRQNRP 240
+ + APE RK ++ASDV+S+GI+MW V++ G V A+ P
Sbjct: 789 PIRWTAPEAI--QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP 846
Query: 241 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
+ P A L +LM CW + RP F + + D++ +
Sbjct: 847 PPMDCPSA---------LHQLMLDCWQKDRNHRPKFGQIVNTLDKMIR 885
>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
sapiens]
Length = 987
Score = 96.7 bits (239), Expect = 5e-20
Identities = 85/288 (29%), Positives = 134/288 (46%), Gaps = 33/288 (11%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYD---VAVKIVNSKAISR-------EVKAMA 65
+ I ++ ++++G G FG V + G VA+K + S + E M
Sbjct: 617 IDISCVKIEQVIGAGEFGEVCSGHLKLPGKREIFVAIKTLKSGYTEKQRRDFLSEASIMG 676
Query: 66 SLDNEFVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL-LCRLLKEV 124
D+ V+ LEGV+ K ++T+FMENGSL L+ + + L +L+ +
Sbjct: 677 QFDHPNVIHLEGVVTK-----STPVMIITEFMENGSLDSFLRQNDGQFTVIQLVGMLRGI 731
Query: 125 VLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTF-QGGSQSGTGSGEPGG-- 181
GM YL D N V HRDL N+L++ L K++DFGLS F + + T + GG
Sbjct: 732 AAGMKYLADMNYV--HRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSDPTYTSALGGKI 789
Query: 182 TLGYLAPELFVNVNRKASTASDVYSFGILMWAVLA-GREVELPTEPSLVYEAVCNRQNRP 240
+ + APE RK ++ASDV+S+GI+MW V++ G V A+ P
Sbjct: 790 PIRWTAPEAI--QYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVINAIEQDYRLP 847
Query: 241 SLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQ 288
+ P A L +LM CW + RP F + + D++ +
Sbjct: 848 PPMDCPSA---------LHQLMLDCWQKDRNHRPKFGQIVNTLDKMIR 886
>gi|21735552 mitogen-activated protein kinase kinase kinase 12 [Homo
sapiens]
Length = 859
Score = 95.9 bits (237), Expect = 8e-20
Identities = 78/273 (28%), Positives = 132/273 (48%), Gaps = 31/273 (11%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISREVKAMASLDNEFVLRL 75
V EE+ + + VG G G VF + G +VAVK V ++K + L + ++
Sbjct: 120 VPFEEILDLQWVGSGAQGAVFLGRFH--GEEVAVKKVRDLK-ETDIKHLRKLKHPNIITF 176
Query: 76 EGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFYLHDQN 135
+GV Q P ++ +F G L +L++ P LL + GM YLH
Sbjct: 177 KGVCT-----QAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLHK 231
Query: 136 PVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELFVNVN 195
++HRDLK N+L+ + VK++DFG S + GT+ ++APE+ N
Sbjct: 232 --IIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFA---GTVAWMAPEVIRN-- 284
Query: 196 RKASTASDVYSFGILMWAVLAGREVELPTEP----SLVYEAVCNRQNRPSLAELPQAGPE 251
S D++SFG+++W +L G E+P + ++++ N + P + P
Sbjct: 285 EPVSEKVDIWSFGVVLWELLTG---EIPYKDVDSSAIIWGVGSNSLHLPVPSSCP----- 336
Query: 252 TPGLEGLKELMQLCWSSEPKDRPSFQECLPKTD 284
+G K L++ CW+S+P++RPSF++ L D
Sbjct: 337 ----DGFKILLRQCWNSKPRNRPSFRQILLHLD 365
>gi|4506401 v-raf-1 murine leukemia viral oncogene homolog 1 [Homo
sapiens]
Length = 648
Score = 95.9 bits (237), Expect = 8e-20
Identities = 81/269 (30%), Positives = 128/269 (47%), Gaps = 35/269 (13%)
Query: 27 VGKGGFGTVFRAQHRKWGYDVAVKIVNS--------KAISREVKAMASLDNEFVLRLEGV 78
+G G FGTV++ KW DVAVKI+ +A EV + + +L G
Sbjct: 355 IGSGSFGTVYKG---KWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGY 411
Query: 79 IEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPL-LCRLLKEVVLGMFYLHDQNPV 137
+ K N A+VT++ E SL L Q + L + ++ GM YLH +N
Sbjct: 412 MTKDNL------AIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKN-- 463
Query: 138 LLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAPELF-VNVNR 196
++HRD+K +N+ L L VK+ DFGL+T + +P G++ ++APE+ + N
Sbjct: 464 IIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNN 523
Query: 197 KASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAGPETPGL- 255
S SDVYS+GI+++ ++ G ELP Y + NR + A P+ L
Sbjct: 524 PFSFQSDVYSYGIVLYELMTG---ELP------YSHINNRDQIIFMVGRGYASPDLSKLY 574
Query: 256 ----EGLKELMQLCWSSEPKDRPSFQECL 280
+ +K L+ C ++RP F + L
Sbjct: 575 KNCPKAMKRLVADCVKKVKEERPLFPQIL 603
>gi|130977759 tec protein tyrosine kinase [Homo sapiens]
Length = 631
Score = 95.1 bits (235), Expect = 1e-19
Identities = 91/288 (31%), Positives = 136/288 (47%), Gaps = 37/288 (12%)
Query: 16 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE-----VKAMASLDNE 70
++ EL +G G FG V + R Y VA+K + A+ E K M L +
Sbjct: 365 INPSELTFMRELGSGLFGVVRLGKWRAQ-YKVAIKAIREGAMCEEDFIEEAKVMMKLTHP 423
Query: 71 FVLRLEGVIEKVNWDQDPKPA-LVTKFMENGSLSGLL-QSQCPRPWPLLCRLLKEVVLGM 128
+++L GV + KP +VT+FME G L L Q Q +L + ++V GM
Sbjct: 424 KLVQLYGVCTQ------QKPIYIVTEFMERGCLLNFLRQRQGHFSRDVLLSMCQDVCEGM 477
Query: 129 FYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPGGTLGYLAP 188
YL + +HRDL N L+ VK++DFG++ + Q + SG + + P
Sbjct: 478 EYLERNS--FIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTSSSGAKF-PVKWCPP 534
Query: 189 ELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVC-----NRQNRPSLA 243
E+F N +R S+ SDV+SFG+LMW V E +P E YE V +R +P LA
Sbjct: 535 EVF-NYSR-FSSKSDVWSFGVLMWEVFT--EGRMPFEKYTNYEVVTMVTRGHRLYQPKLA 590
Query: 244 ELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEVFQMVE 291
+ E+M CW +P+ RPSF++ L DE+ + E
Sbjct: 591 S-----------NYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVECEE 627
>gi|205277435 spleen tyrosine kinase isoform 2 [Homo sapiens]
Length = 612
Score = 94.4 bits (233), Expect = 2e-19
Identities = 82/267 (30%), Positives = 129/267 (48%), Gaps = 30/267 (11%)
Query: 21 LENQELVGKGGFGTVFRA--QHRKWGYDVAVKIVNSKA--------ISREVKAMASLDNE 70
LE++EL G G FGTV + Q +K VAVKI+ ++A + E M LDN
Sbjct: 349 LEDKEL-GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 407
Query: 71 FVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFY 130
+++R+ G+ E +W LV + E G L+ LQ + L+ +V +GM Y
Sbjct: 408 YIVRMIGICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 461
Query: 131 LHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG-GTLGYLAPE 189
L + N +HRDL NVLL + + K++DFGLS ++ + G + + APE
Sbjct: 462 LEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 519
Query: 190 LFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAG 249
+N K S+ SDV+SFG+LMW + + Y + + L + + G
Sbjct: 520 C-INY-YKFSSKSDVWSFGVLMWEAFSYGQKP--------YRGMKGSEVTAMLEKGERMG 569
Query: 250 PETPGLEGLKELMQLCWSSEPKDRPSF 276
+ +LM LCW+ + ++RP F
Sbjct: 570 CPAGCPREMYDLMNLCWTYDVENRPGF 596
>gi|21361553 spleen tyrosine kinase isoform 1 [Homo sapiens]
Length = 635
Score = 94.4 bits (233), Expect = 2e-19
Identities = 82/267 (30%), Positives = 129/267 (48%), Gaps = 30/267 (11%)
Query: 21 LENQELVGKGGFGTVFRA--QHRKWGYDVAVKIVNSKA--------ISREVKAMASLDNE 70
LE++EL G G FGTV + Q +K VAVKI+ ++A + E M LDN
Sbjct: 372 LEDKEL-GSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNP 430
Query: 71 FVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRPWPLLCRLLKEVVLGMFY 130
+++R+ G+ E +W LV + E G L+ LQ + L+ +V +GM Y
Sbjct: 431 YIVRMIGICEAESW------MLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKY 484
Query: 131 LHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQSGTGSGEPG-GTLGYLAPE 189
L + N +HRDL NVLL + + K++DFGLS ++ + G + + APE
Sbjct: 485 LEESN--FVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPE 542
Query: 190 LFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSLVYEAVCNRQNRPSLAELPQAG 249
+N K S+ SDV+SFG+LMW + + Y + + L + + G
Sbjct: 543 C-INY-YKFSSKSDVWSFGVLMWEAFSYGQKP--------YRGMKGSEVTAMLEKGERMG 592
Query: 250 PETPGLEGLKELMQLCWSSEPKDRPSF 276
+ +LM LCW+ + ++RP F
Sbjct: 593 CPAGCPREMYDLMNLCWTYDVENRPGF 619
>gi|148596974 TXK tyrosine kinase [Homo sapiens]
Length = 527
Score = 94.4 bits (233), Expect = 2e-19
Identities = 87/287 (30%), Positives = 137/287 (47%), Gaps = 43/287 (14%)
Query: 12 PAPLVSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKAISRE-----VKAMAS 66
P+ L I+E +G G FG V + R VA+K +N ++S E K M
Sbjct: 268 PSELAFIKE------IGSGQFGVVHLGEWRSH-IQVAIKAINEGSMSEEDFIEEAKVMMK 320
Query: 67 LDNEFVLRLEGVIEKVNWDQDPKPA-LVTKFMENGSLSGLLQSQCPR-PWPLLCRLLKEV 124
L + +++L GV + KP +VT+FMENG L L+ + +L + +++
Sbjct: 321 LSHSKLVQLYGVCIQ------RKPLYIVTEFMENGCLLNYLRENKGKLRKEMLLSVCQDI 374
Query: 125 VLGMFYLHDQNPVLLHRDLKPSNVLLDPELHVKLADFGLSTFQGGSQ--SGTGSGEPGGT 182
GM YL +HRDL N L+ VK++DFG++ + + S G+ P
Sbjct: 375 CEGMEYLERNG--YIHRDLAARNCLVSSTCIVKISDFGMTRYVLDDEYVSSFGAKFP--- 429
Query: 183 LGYLAPELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEPSL-VYEAVCN--RQNR 239
+ + PE+F+ K S+ SDV+SFG+LMW V ++ + +L V EA+ R R
Sbjct: 430 IKWSPPEVFLF--NKYSSKSDVWSFGVLMWEVFTEGKMPFENKSNLQVVEAISEGFRLYR 487
Query: 240 PSLAELPQAGPETPGLEGLKELMQLCWSSEPKDRPSFQECLPKTDEV 286
P LA + + E+M CW +P+ RP+F E L E+
Sbjct: 488 PHLAPM-----------SIYEVMYSCWHEKPEGRPTFAELLRAVTEI 523
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.131 0.404
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,147,073
Number of Sequences: 37866
Number of extensions: 1414846
Number of successful extensions: 7728
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 590
Number of HSP's successfully gapped in prelim test: 357
Number of HSP's that attempted gapping in prelim test: 5177
Number of HSP's gapped (non-prelim): 1874
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.