Guide to the Human Genome
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Search of human proteins with 40068059

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|40068059 CBF1 interacting corepressor [Homo sapiens]
         (450 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|40068059 CBF1 interacting corepressor [Homo sapiens]               914   0.0  
gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]           87   4e-17
gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]           87   4e-17
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    86   9e-17
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [...    86   9e-17
gi|8923271 coiled-coil domain containing 49 [Homo sapiens]             84   3e-16
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            82   1e-15
gi|42560244 peptidylprolyl isomerase G [Homo sapiens]                  81   2e-15
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     80   3e-15
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ...    77   2e-14
gi|27734775 hypothetical protein LOC286499 [Homo sapiens]              77   2e-14
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            77   4e-14
gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo s...    75   9e-14
gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]     71   2e-12
gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]           71   2e-12
gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]    71   2e-12
gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]    71   2e-12
gi|52426743 cisplatin resistance-associated overexpressed protei...    71   2e-12
gi|19923485 cisplatin resistance-associated overexpressed protei...    71   2e-12
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    69   7e-12
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]        69   7e-12
gi|50962882 G patch domain containing 8 [Homo sapiens]                 69   9e-12
gi|154146223 splicing factor, arginine/serine-rich 130 [Homo sap...    69   1e-11
gi|154146193 splicing factor, arginine/serine-rich 130 [Homo sap...    69   1e-11
gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]    68   2e-11
gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo sap...    67   3e-11
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                67   3e-11
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]            67   3e-11
gi|33356174 pinin, desmosome associated protein [Homo sapiens]         67   4e-11
gi|38488727 arginine/serine-rich coiled-coil 1 [Homo sapiens]          66   7e-11

>gi|40068059 CBF1 interacting corepressor [Homo sapiens]
          Length = 450

 Score =  914 bits (2361), Expect = 0.0
 Identities = 450/450 (100%), Positives = 450/450 (100%)

Query: 1   MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMG 60
           MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMG
Sbjct: 1   MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMG 60

Query: 61  DERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFG 120
           DERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFG
Sbjct: 61  DERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFG 120

Query: 121 IQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFA 180
           IQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFA
Sbjct: 121 IQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFA 180

Query: 181 LKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDR 240
           LKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDR
Sbjct: 181 LKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDR 240

Query: 241 KKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS 300
           KKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS
Sbjct: 241 KKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS 300

Query: 301 GHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR 360
           GHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR
Sbjct: 301 GHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR 360

Query: 361 THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRND 420
           THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRND
Sbjct: 361 THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRND 420

Query: 421 SRSHGTDLYRGEKMYREHPGGTHTKVTQRE 450
           SRSHGTDLYRGEKMYREHPGGTHTKVTQRE
Sbjct: 421 SRSHGTDLYRGEKMYREHPGGTHTKVTQRE 450


>gi|21040326 SON DNA-binding protein isoform F [Homo sapiens]
          Length = 2426

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 66/229 (28%), Positives = 113/229 (49%), Gaps = 14/229 (6%)

Query: 201  ASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSS 260
            +SE ++D E+ F+K   T +K K  +  D+ EK+KK+    + + ++S+S   K +  +S
Sbjct: 1783 SSEEKDDYEI-FVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTS 1841

Query: 261  SSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEE-----KDKSKK 315
             S S +   S+++    S++ S ++ ++ +R  R ++K  G  +   E+     K +SK 
Sbjct: 1842 ESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKS 1901

Query: 316  RKLHEELSSSHHNREKAKEKPRFLKHES-SREDSKWSHSDSDKKSRTHKHSPEKRGSERK 374
            R+   + SSS  NR+  + + R     S S   S+   S S  + R+   SP +R S   
Sbjct: 1902 RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRR-SRTP 1960

Query: 375  EGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
               SR+  R  R+   RSR+P   ++  T  R  R P    SRR  SRS
Sbjct: 1961 SRRSRTPSRRSRTPSRRSRTPS--RRSRTPSRRSRTP----SRRRRSRS 2003



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 54/189 (28%), Positives = 74/189 (39%), Gaps = 33/189 (17%)

Query: 260  SSSSSSSSSSSTETSESSSESESNNK---EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKR 316
            S++S   SS     SESSSE + + +   + K   +K KKNK           +DK +K 
Sbjct: 1766 SAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNK----------NRDKGEKE 1815

Query: 317  KLHEELSSSHHNREKAKE-KPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKE 375
            K  +    S   R K+ E K R    ES     K S      +S+T   S  +R      
Sbjct: 1816 KKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSR 1875

Query: 376  GSSRSHGREERSRRSRSRSPGSYKQRETRKR-------------------AQRNPGEEQS 416
              S+S GR   S+  R RSP    +   RKR                   ++R+     S
Sbjct: 1876 SRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPS 1935

Query: 417  RRNDSRSHG 425
            RR  SRS G
Sbjct: 1936 RRRRSRSVG 1944



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 57/217 (26%), Positives = 88/217 (40%), Gaps = 13/217 (5%)

Query: 214  KSLTTKQKQKLLRKLDRLEKKKKK-KDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTE 272
            KS   K +++      R  K+  K K  + +   +SRS+ ++  S S S S    S S E
Sbjct: 1830 KSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKE 1889

Query: 273  TSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKA 332
              + S +  S ++E+K +R   + N+ +    S +  +            S S   R   
Sbjct: 1890 KRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSF 1949

Query: 333  KEKPRFLKHESSREDSKWSHSDSDKKSRT---HKHSPEKRGSERKEGSSRSHGREERSR- 388
               P       SR  S+ S + S ++SRT      +P +R S      SR+  R  RSR 
Sbjct: 1950 SISP----SRRSRTPSRRSRTPS-RRSRTPSRRSRTPSRR-SRTPSRRSRTPSRRRRSRS 2003

Query: 389  --RSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
              R RS S    + R +R   +R       RR  SRS
Sbjct: 2004 VVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040



 Score = 32.7 bits (73), Expect = 0.69
 Identities = 23/93 (24%), Positives = 38/93 (40%), Gaps = 10/93 (10%)

Query: 251 KHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEK 310
           ++K      S  S   S  +  T E  ++    +K+ K ++KK+KK K   +     E +
Sbjct: 78  RYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESE 137

Query: 311 DKSKKRKLHEELSSSHHNREKAKEKPRFLKHES 343
            K+K          SH +     E   FLK +S
Sbjct: 138 SKTK----------SHDDGNIDLESDSFLKFDS 160



 Score = 32.3 bits (72), Expect = 0.90
 Identities = 17/52 (32%), Positives = 32/52 (61%), Gaps = 1/52 (1%)

Query: 216 LTTKQKQKLLRKLDRLEKKKKKKDRK-KKKFQKSRSKHKKHKSSSSSSSSSS 266
           + TK+ +K  +  ++ +KKKK+K++K K++ ++S SK K H   +    S S
Sbjct: 103 IPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDS 154



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 14/46 (30%), Positives = 24/46 (52%)

Query: 232 EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESS 277
           +K KK K++KKKK ++   K+K+    S S + S    + +    S
Sbjct: 109 KKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDS 154


>gi|21040314 SON DNA-binding protein isoform B [Homo sapiens]
          Length = 2303

 Score = 86.7 bits (213), Expect = 4e-17
 Identities = 66/229 (28%), Positives = 113/229 (49%), Gaps = 14/229 (6%)

Query: 201  ASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSS 260
            +SE ++D E+ F+K   T +K K  +  D+ EK+KK+    + + ++S+S   K +  +S
Sbjct: 1783 SSEEKDDYEI-FVKVKDTHEKSKKNKNRDKGEKEKKRDSSLRSRSKRSKSSEHKSRKRTS 1841

Query: 261  SSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEE-----KDKSKK 315
             S S +   S+++    S++ S ++ ++ +R  R ++K  G  +   E+     K +SK 
Sbjct: 1842 ESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKEKRKRSPKHRSKS 1901

Query: 316  RKLHEELSSSHHNREKAKEKPRFLKHES-SREDSKWSHSDSDKKSRTHKHSPEKRGSERK 374
            R+   + SSS  NR+  + + R     S S   S+   S S  + R+   SP +R S   
Sbjct: 1902 RERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSFSISPSRR-SRTP 1960

Query: 375  EGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
               SR+  R  R+   RSR+P   ++  T  R  R P    SRR  SRS
Sbjct: 1961 SRRSRTPSRRSRTPSRRSRTPS--RRSRTPSRRSRTP----SRRRRSRS 2003



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 54/189 (28%), Positives = 74/189 (39%), Gaps = 33/189 (17%)

Query: 260  SSSSSSSSSSSTETSESSSESESNNK---EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKR 316
            S++S   SS     SESSSE + + +   + K   +K KKNK           +DK +K 
Sbjct: 1766 SAASPVVSSMPERASESSSEEKDDYEIFVKVKDTHEKSKKNK----------NRDKGEKE 1815

Query: 317  KLHEELSSSHHNREKAKE-KPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKE 375
            K  +    S   R K+ E K R    ES     K S      +S+T   S  +R      
Sbjct: 1816 KKRDSSLRSRSKRSKSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSR 1875

Query: 376  GSSRSHGREERSRRSRSRSPGSYKQRETRKR-------------------AQRNPGEEQS 416
              S+S GR   S+  R RSP    +   RKR                   ++R+     S
Sbjct: 1876 SRSKSRGRRSVSKEKRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPS 1935

Query: 417  RRNDSRSHG 425
            RR  SRS G
Sbjct: 1936 RRRRSRSVG 1944



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 57/217 (26%), Positives = 88/217 (40%), Gaps = 13/217 (5%)

Query: 214  KSLTTKQKQKLLRKLDRLEKKKKK-KDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTE 272
            KS   K +++      R  K+  K K  + +   +SRS+ ++  S S S S    S S E
Sbjct: 1830 KSSEHKSRKRTSESRSRARKRSSKSKSHRSQTRSRSRSRRRRRSSRSRSKSRGRRSVSKE 1889

Query: 273  TSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKA 332
              + S +  S ++E+K +R   + N+ +    S +  +            S S   R   
Sbjct: 1890 KRKRSPKHRSKSRERKRKRSSSRDNRKTVRARSRTPSRRSRSHTPSRRRRSRSVGRRRSF 1949

Query: 333  KEKPRFLKHESSREDSKWSHSDSDKKSRT---HKHSPEKRGSERKEGSSRSHGREERSR- 388
               P       SR  S+ S + S ++SRT      +P +R S      SR+  R  RSR 
Sbjct: 1950 SISP----SRRSRTPSRRSRTPS-RRSRTPSRRSRTPSRR-SRTPSRRSRTPSRRRRSRS 2003

Query: 389  --RSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
              R RS S    + R +R   +R       RR  SRS
Sbjct: 2004 VVRRRSFSISPVRLRRSRTPLRRRFSRSPIRRKRSRS 2040



 Score = 32.7 bits (73), Expect = 0.69
 Identities = 23/93 (24%), Positives = 38/93 (40%), Gaps = 10/93 (10%)

Query: 251 KHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEK 310
           ++K      S  S   S  +  T E  ++    +K+ K ++KK+KK K   +     E +
Sbjct: 78  RYKPDLKEGSRKSRCVSVQTDPTDEIPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESE 137

Query: 311 DKSKKRKLHEELSSSHHNREKAKEKPRFLKHES 343
            K+K          SH +     E   FLK +S
Sbjct: 138 SKTK----------SHDDGNIDLESDSFLKFDS 160



 Score = 32.3 bits (72), Expect = 0.90
 Identities = 17/52 (32%), Positives = 32/52 (61%), Gaps = 1/52 (1%)

Query: 216 LTTKQKQKLLRKLDRLEKKKKKKDRK-KKKFQKSRSKHKKHKSSSSSSSSSS 266
           + TK+ +K  +  ++ +KKKK+K++K K++ ++S SK K H   +    S S
Sbjct: 103 IPTKKSKKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDS 154



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 14/46 (30%), Positives = 24/46 (52%)

Query: 232 EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESS 277
           +K KK K++KKKK ++   K+K+    S S + S    + +    S
Sbjct: 109 KKHKKHKNKKKKKKKEKEKKYKRQPEESESKTKSHDDGNIDLESDS 154


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 65/232 (28%), Positives = 98/232 (42%), Gaps = 22/232 (9%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKF-QKSRSKHKKHKSSSSSSSSSSSSSSTE----- 272
           K+ Q   R       + ++KDR++ K   K RSK ++ + S S S S      T      
Sbjct: 327 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE 386

Query: 273 ---TSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNR 329
                E   E E   ++++ + K+R KNK          EKDK K R+   E     H +
Sbjct: 387 KERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERERE---KEHEK 443

Query: 330 EKAKEKPRFLKHESSREDSKWSHSDS----DKKSRTHKHSPEKRGSERKEGSSRSHGREE 385
           ++ KEK +    E  RE  +    D     DKKSRT    P    + R+   SRS  RE 
Sbjct: 444 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT---PPRSYNASRR---SRSSSRER 497

Query: 386 RSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
           R RRSRS S      +  ++++ R+P      + D +      +  E+  RE
Sbjct: 498 RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 549



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 45/185 (24%), Positives = 85/185 (45%), Gaps = 12/185 (6%)

Query: 242 KKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKK---RKKNK 298
           ++K  +SRS H + KS SSS S S    S     S S + S +++K  +R K   +K++K
Sbjct: 302 ERKGGRSRS-HTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK 360

Query: 299 CSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKK 358
                 S S    + K++   E++      +EK +EK R  + E  +E  +  + D DK+
Sbjct: 361 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 420

Query: 359 SRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRR 418
               +   +++  ER+        RE+   + R +     + +E  +   R+   ++ R+
Sbjct: 421 REKDREKDKEKDRERE--------REKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK 472

Query: 419 NDSRS 423
            D +S
Sbjct: 473 KDKKS 477



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 41/198 (20%), Positives = 82/198 (41%), Gaps = 4/198 (2%)

Query: 214 KSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTET 273
           K   T++K K   ++   +++K+++  K+++ +K R K+K                  E 
Sbjct: 376 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER 435

Query: 274 SESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAK 333
                  +  +KEK+ ++ K K+ +       D + K   K R      ++S  +R  ++
Sbjct: 436 EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 495

Query: 334 EKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRG-SERKEGSSRSHGREERSRRSRS 392
           E+ R     SSR       S + K+  +   SP  R   ++K    R H  E R R   +
Sbjct: 496 ERRRRRSRSSSRSPRT---SKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERST 552

Query: 393 RSPGSYKQRETRKRAQRN 410
               S   R+ +++ ++N
Sbjct: 553 SMRKSSNDRDGKEKLEKN 570



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 45/223 (20%), Positives = 94/223 (42%), Gaps = 9/223 (4%)

Query: 205 EEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKK---KKFQKSRSKHKKHKSSSSS 261
           E+  E E +K    +++++  ++ ++ +++ K KDR K   K  +K + K ++ +     
Sbjct: 382 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEH 441

Query: 262 SSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHN-NSDSEEKDKSKKRKLHE 320
                     E  +     +  +KE   +RKK KK++    + N+    +  S++R+   
Sbjct: 442 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 501

Query: 321 ELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRS 380
             SSS   R       + +K +SSR  S  S +  DKK    +    +R    +  S R 
Sbjct: 502 SRSSSRSPRTS-----KTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 556

Query: 381 HGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
              +   +    ++  S K++E  K    +  +E   ++  R+
Sbjct: 557 SSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRT 599



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 45/179 (25%), Positives = 87/179 (48%), Gaps = 15/179 (8%)

Query: 205 EEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSS 264
           E + E E  K    +++++  ++ +R + + K+ D K+KK +KSR+  + + +S  S SS
Sbjct: 434 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSS 493

Query: 265 S---------SSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKK 315
           S         SSS S  TS++     S +   + + KK KK +    + S+  E+++S  
Sbjct: 494 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 553

Query: 316 RKLHEELSSSHHNREKAKEKPRFLKHE--SSREDSKWSHSDSDKKS-RTHKHSPEKRGS 371
            +   + S+    +EK ++    LK +  +   DS  S    DK + RT ++  +  G+
Sbjct: 554 MR---KSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGN 609


>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
           [Homo sapiens]
          Length = 508

 Score = 85.5 bits (210), Expect = 9e-17
 Identities = 65/232 (28%), Positives = 98/232 (42%), Gaps = 22/232 (9%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKF-QKSRSKHKKHKSSSSSSSSSSSSSSTE----- 272
           K+ Q   R       + ++KDR++ K   K RSK ++ + S S S S      T      
Sbjct: 211 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE 270

Query: 273 ---TSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNR 329
                E   E E   ++++ + K+R KNK          EKDK K R+   E     H +
Sbjct: 271 KERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERERE---KEHEK 327

Query: 330 EKAKEKPRFLKHESSREDSKWSHSDS----DKKSRTHKHSPEKRGSERKEGSSRSHGREE 385
           ++ KEK +    E  RE  +    D     DKKSRT    P    + R+   SRS  RE 
Sbjct: 328 DRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRT---PPRSYNASRR---SRSSSRER 381

Query: 386 RSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
           R RRSRS S      +  ++++ R+P      + D +      +  E+  RE
Sbjct: 382 RRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERE 433



 Score = 70.1 bits (170), Expect = 4e-12
 Identities = 45/185 (24%), Positives = 85/185 (45%), Gaps = 12/185 (6%)

Query: 242 KKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKK---RKKNK 298
           ++K  +SRS H + KS SSS S S    S     S S + S +++K  +R K   +K++K
Sbjct: 186 ERKGGRSRS-HTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSK 244

Query: 299 CSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKK 358
                 S S    + K++   E++      +EK +EK R  + E  +E  +  + D DK+
Sbjct: 245 SRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKE 304

Query: 359 SRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRR 418
               +   +++  ER+        RE+   + R +     + +E  +   R+   ++ R+
Sbjct: 305 REKDREKDKEKDRERE--------REKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK 356

Query: 419 NDSRS 423
            D +S
Sbjct: 357 KDKKS 361



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 41/198 (20%), Positives = 82/198 (41%), Gaps = 4/198 (2%)

Query: 214 KSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTET 273
           K   T++K K   ++   +++K+++  K+++ +K R K+K                  E 
Sbjct: 260 KRKDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRER 319

Query: 274 SESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAK 333
                  +  +KEK+ ++ K K+ +       D + K   K R      ++S  +R  ++
Sbjct: 320 EREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSR 379

Query: 334 EKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRG-SERKEGSSRSHGREERSRRSRS 392
           E+ R     SSR       S + K+  +   SP  R   ++K    R H  E R R   +
Sbjct: 380 ERRRRRSRSSSRSPRT---SKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERST 436

Query: 393 RSPGSYKQRETRKRAQRN 410
               S   R+ +++ ++N
Sbjct: 437 SMRKSSNDRDGKEKLEKN 454



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 45/223 (20%), Positives = 94/223 (42%), Gaps = 9/223 (4%)

Query: 205 EEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKK---KKFQKSRSKHKKHKSSSSS 261
           E+  E E +K    +++++  ++ ++ +++ K KDR K   K  +K + K ++ +     
Sbjct: 266 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEH 325

Query: 262 SSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHN-NSDSEEKDKSKKRKLHE 320
                     E  +     +  +KE   +RKK KK++    + N+    +  S++R+   
Sbjct: 326 EKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRR 385

Query: 321 ELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRS 380
             SSS   R       + +K +SSR  S  S +  DKK    +    +R    +  S R 
Sbjct: 386 SRSSSRSPRTS-----KTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRK 440

Query: 381 HGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
              +   +    ++  S K++E  K    +  +E   ++  R+
Sbjct: 441 SSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRT 483



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 45/179 (25%), Positives = 87/179 (48%), Gaps = 15/179 (8%)

Query: 205 EEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSS 264
           E + E E  K    +++++  ++ +R + + K+ D K+KK +KSR+  + + +S  S SS
Sbjct: 318 EREREKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSS 377

Query: 265 S---------SSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKK 315
           S         SSS S  TS++     S +   + + KK KK +    + S+  E+++S  
Sbjct: 378 SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTS 437

Query: 316 RKLHEELSSSHHNREKAKEKPRFLKHE--SSREDSKWSHSDSDKKS-RTHKHSPEKRGS 371
            +   + S+    +EK ++    LK +  +   DS  S    DK + RT ++  +  G+
Sbjct: 438 MR---KSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGN 493


>gi|8923271 coiled-coil domain containing 49 [Homo sapiens]
          Length = 425

 Score = 84.0 bits (206), Expect = 3e-16
 Identities = 102/441 (23%), Positives = 179/441 (40%), Gaps = 90/441 (20%)

Query: 11  KKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGD----ERVKN 66
           KK +HP +  N++KVW AEQK   ++KK EEL ++  +E+   + +    D    ++ + 
Sbjct: 9   KKSWHPQTLRNVEKVWKAEQKHEAERKKIEELQRELREERAREEMQRYAEDVGAVKKKEE 68

Query: 67  GLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNV 126
            L++MY+ P G    +              E+  G P +KY  + M              
Sbjct: 69  KLDWMYQGPGGMVNRD--------------EYLLGRPIDKYVFEKME------------- 101

Query: 127 RCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVL 186
                        ++E      +G+   S+       S+   ++ +++R           
Sbjct: 102 -------------EKEAGCSSETGLLPGSIFAPSGANSL--LDMASKIRE---------- 136

Query: 187 GRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQ 246
                  DP   ++  + EE+ + E L +    +K K L ++  LEKK+KKK ++KKK  
Sbjct: 137 -------DPL--FIIRKKEEEKKREVLNNPVKMKKIKELLQMS-LEKKEKKKKKEKKK-- 184

Query: 247 KSRSKHKKHK--SSSSSSSSSSSSSSTETSESSSESESN--NKEKKIQRKKRKKNKCSGH 302
               KHKKHK  SSSS  SSS    S   S+    + S   +K      + R  ++  G 
Sbjct: 185 ----KHKKHKHRSSSSDRSSSEDEHSAGRSQKKMANSSPVLSKVPGYGLQVRNSDRNQGL 240

Query: 303 NNSDSEEKDKSKKRKLHEELSSSHHN--REKAKEKPRFLKHESSREDSKWSHSDSDKKSR 360
               + E+ +    K H    SS H+  R  +K+  R       R  S    S S + S+
Sbjct: 241 QGPLTAEQKRGHGMKNHSRSRSSSHSPPRHASKKSTREAGSRDRRSRSLGRRSRSPRPSK 300

Query: 361 THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYK-------QRETRKRAQRNPGE 413
            H      + + R+ G +RS    ++    R  +PG  +       +R+ ++  +     
Sbjct: 301 LH----NSKVNRRETGQTRSPS-PKKEVYQRRHAPGYTRKLSAEELERKRQEMMENAKWR 355

Query: 414 EQSRRNDSRSHGTDLYRGEKM 434
           E+ R N  + H  D  R +++
Sbjct: 356 EEERLNILKRHAKDEEREQRL 376



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 52/230 (22%), Positives = 85/230 (36%), Gaps = 22/230 (9%)

Query: 242 KKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSG 301
           K  F+K   K     S +     S  + S   S     S+       I RKK ++ K   
Sbjct: 94  KYVFEKMEEKEAGCSSETGLLPGSIFAPSGANSLLDMASKIREDPLFIIRKKEEEKKREV 153

Query: 302 HNNS------------DSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSK 349
            NN               E+K+K KK++  ++     H    +       +H + R   K
Sbjct: 154 LNNPVKMKKIKELLQMSLEKKEKKKKKEKKKKHKKHKHRSSSSDRSSSEDEHSAGRSQKK 213

Query: 350 WSHSDSDKKSRTHKHSPEKRGSERKEG--------SSRSHGREERSR-RSRSRSPGSYKQ 400
            ++S S   S+   +  + R S+R +G          R HG +  SR RS S SP  +  
Sbjct: 214 MANS-SPVLSKVPGYGLQVRNSDRNQGLQGPLTAEQKRGHGMKNHSRSRSSSHSPPRHAS 272

Query: 401 RETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTKVTQRE 450
           +++ + A       +S    SRS         K+ R   G T +   ++E
Sbjct: 273 KKSTREAGSRDRRSRSLGRRSRSPRPSKLHNSKVNRRETGQTRSPSPKKE 322


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 50/216 (23%), Positives = 105/216 (48%), Gaps = 20/216 (9%)

Query: 226 RKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNK 285
           R+++  ++ KK+++ ++KK ++ R K K+ +               +      E +   K
Sbjct: 43  REIETRKEGKKERESERKKERREREKRKREREKER-----------KRERGKKEKKGERK 91

Query: 286 EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR 345
           +++ +RKKR++ K     N + EEK+K KK++  E   +S   +E+ +++ R  +    R
Sbjct: 92  KEERERKKRRREK----ENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKER 147

Query: 346 EDSKWSHSD----SDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQR 401
           E  K          ++K R  K   EK   ERKE   +   + ER+R+ R +     ++R
Sbjct: 148 ERKKEEREKERERKERKKRERKQVGEKE-EERKEKERKERKKRERNRKERKKERERKERR 206

Query: 402 ETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
           E +K  ++    ++ R+ D +++  +  RG++  +E
Sbjct: 207 ERKKERKKKEERKKERQKDRQTNWREKERGKRERKE 242



 Score = 80.1 bits (196), Expect = 4e-15
 Identities = 51/214 (23%), Positives = 94/214 (43%), Gaps = 10/214 (4%)

Query: 205 EEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSS 264
           E + E+E  K    K++++  RK +R E++K+K++R+K   ++ R + KK K        
Sbjct: 40  EREREIETRKE--GKKERESERKKERREREKRKREREK---ERKRERGKKEKKGERKKEE 94

Query: 265 SSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSS 324
                     E+  E E   K KK ++K+R +    G      EE+ + ++++   +   
Sbjct: 95  RERKKRRREKENK-EGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEE 153

Query: 325 SHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGRE 384
               RE+ + K R  K    +E+ +      ++K R       K+  ERKE   R   R+
Sbjct: 154 REKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERK 213

Query: 385 ERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRR 418
           ++  R + R     K R+T  R +     E+  R
Sbjct: 214 KKEERKKERQ----KDRQTNWREKERGKRERKER 243



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 46/205 (22%), Positives = 94/205 (45%), Gaps = 11/205 (5%)

Query: 203 EGEEDPEVEFLKSLTTKQKQKLLRKLDRL-EKKKKKKDRKKKKFQKSRSKHKKHKSSSSS 261
           EG+++ E E  K    ++K+K  R+ +R  E+ KK+K  ++KK ++ R K ++ K +   
Sbjct: 50  EGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEG 109

Query: 262 SSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEE 321
                     +     +  E   +E+K +RK+ ++ +         +E+++ +++K   +
Sbjct: 110 EEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERK 169

Query: 322 LSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSH 381
                    K KE+    K E +R++ K        K R  K   E++  ERK+   R  
Sbjct: 170 QVGEKEEERKEKERKERKKRERNRKERK--------KERERKERRERK-KERKKKEERKK 220

Query: 382 GRE-ERSRRSRSRSPGSYKQRETRK 405
            R+ +R    R +  G  +++E +K
Sbjct: 221 ERQKDRQTNWREKERGKRERKERKK 245



 Score = 61.2 bits (147), Expect = 2e-09
 Identities = 46/204 (22%), Positives = 83/204 (40%), Gaps = 3/204 (1%)

Query: 247 KSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSD 306
           K+ S     K ++     S S  S   ++   +SE   +E++I+ +K  K +       +
Sbjct: 3   KAISSRAAVKLNTELQMVSCSHISKPCTQPGWQSEIREREREIETRKEGKKERESERKKE 62

Query: 307 SEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSP 366
             E++K +KR+  +E       +EK  E+ +  +    R   K +    +K+ R  K   
Sbjct: 63  RREREK-RKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKK 121

Query: 367 EKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGT 426
           E RG   KEG  R   +EER R  R       ++RE  +  +     E+ +  +      
Sbjct: 122 E-RGRTSKEGKERER-KEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERK 179

Query: 427 DLYRGEKMYREHPGGTHTKVTQRE 450
           +  R E+  RE       K  +R+
Sbjct: 180 EKERKERKKRERNRKERKKERERK 203



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 37/188 (19%), Positives = 82/188 (43%), Gaps = 11/188 (5%)

Query: 188 RNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQK 247
           R     +  +E     G+++ + E  K    ++K++  ++    E+K+K+K ++KK    
Sbjct: 66  REKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKK---- 121

Query: 248 SRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDS 307
                ++ ++S                    E +   +EK+ +RK+RKK +       + 
Sbjct: 122 -----ERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEE 176

Query: 308 EEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPE 367
           E K+K +K +   E +     +E+ +++ R  K E  +++ +      D+++   +    
Sbjct: 177 ERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERG 236

Query: 368 KRGSERKE 375
           KR  ERKE
Sbjct: 237 KR--ERKE 242



 Score = 37.4 bits (85), Expect = 0.028
 Identities = 25/122 (20%), Positives = 52/122 (42%), Gaps = 11/122 (9%)

Query: 201 ASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSS 260
           + EG+E    E  K    K+++   RK +  EK++++K+RKK++ ++   K ++ K    
Sbjct: 127 SKEGKERERKEERKREERKERE---RKKEEREKERERKERKKRERKQVGEKEEERKEKER 183

Query: 261 SSSSSSSSSSTETSESSSESESNNK--------EKKIQRKKRKKNKCSGHNNSDSEEKDK 312
                   +  E  +     E   +        E+K +R+K ++           E K++
Sbjct: 184 KERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKER 243

Query: 313 SK 314
            K
Sbjct: 244 KK 245



 Score = 32.7 bits (73), Expect = 0.69
 Identities = 21/99 (21%), Positives = 44/99 (44%), Gaps = 3/99 (3%)

Query: 197 QEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKK---DRKKKKFQKSRSKHK 253
           +E    E E++ E +  K    KQ  +   +    E+K++KK   +RK++K ++ R + +
Sbjct: 147 RERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERR 206

Query: 254 KHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRK 292
           + K               +   +  E E   +E+K ++K
Sbjct: 207 ERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245


>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
          Length = 754

 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 73/266 (27%), Positives = 117/266 (43%), Gaps = 31/266 (11%)

Query: 188 RNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQK 247
           R +T +    E    + E++ +V+  KS     K++ +R+    + K K K +K+ K  K
Sbjct: 404 RKITDHRNVSESPNRKNEKEKKVKDHKS---NSKERDIRRNSEKDDKYKNKVKKRAK-SK 459

Query: 248 SRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDS 307
           SRSK K+      S S    S      E    S S  ++ +  ++K K++   G +   S
Sbjct: 460 SRSKSKE-----KSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERS 514

Query: 308 EEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSRED-SKWSHS-DSDKKSRTHKHS 365
             K+KSK+     E  S+ H+  K+KEK R  +  S   D +K  HS +S  + R+    
Sbjct: 515 RSKEKSKQL----ESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRD 570

Query: 366 PEKRGSERKEGSSRSHGRE-------ERSRRSRSRS------PGSYKQRETRKRAQRNPG 412
             +R   R     RS  +E       E  RR RSRS      PG  + ++ R+R +    
Sbjct: 571 RSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRR---D 627

Query: 413 EEQSRRNDSRSHGTDLYRGEKMYREH 438
              S R +S+S   D YR ++    H
Sbjct: 628 SRSSEREESQSRNKDKYRNQESKSSH 653



 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 60/223 (26%), Positives = 104/223 (46%), Gaps = 23/223 (10%)

Query: 229 DRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKK 288
           +R  K  K +  + K+ Q+S  + K+ K +   + S S +   E  +   + +SN+KE+ 
Sbjct: 378 ERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERD 437

Query: 289 IQRKKRK----KNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESS 344
           I+R   K    KNK      S S  K K K +    +   + +  ++ + + +   HE+ 
Sbjct: 438 IRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENV 497

Query: 345 REDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGR---EERSRRSRSRS------- 394
           +E  K     SD K +  + S  K  S++ E  S  H     +E+ RR++SRS       
Sbjct: 498 KEKEK----QSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITK 553

Query: 395 -PGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYR 436
              SY  R TR+R++     ++SRR  SR+H  D  R ++ +R
Sbjct: 554 GKHSYNSR-TRERSR---SRDRSRRVRSRTHDRDRSRSKEYHR 592



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 63/287 (21%), Positives = 125/287 (43%), Gaps = 23/287 (8%)

Query: 162 GPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQK 221
           G     +E+    R+     +R +      +  P+++    +  +D +    +    +  
Sbjct: 383 GDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNS 442

Query: 222 QKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSS----SSSSSSSSTETSESS 277
           +K  +  ++++K+ K K R K K +KS+SK +  K + +      S S         E  
Sbjct: 443 EKDDKYKNKVKKRAKSKSRSKSK-EKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKE 501

Query: 278 SESESNNKEKKIQRKKRK----KNKCSGHNNSDSEEKDKSKKRKLHE-ELSSSHHN---- 328
            +S+S  K+++  R K K    ++K + H++S S+EKD+  + +  E +++   H+    
Sbjct: 502 KQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSR 561

Query: 329 -REKAKEKPRFLK-----HESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHG 382
            RE+++ + R  +     H+  R  SK  H   +++ R    S   R  ER+    RS  
Sbjct: 562 TRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRS---RSRERRTPPGRSRS 618

Query: 383 REERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLY 429
           ++ R RR  SRS    + +   K   RN   + S R ++      +Y
Sbjct: 619 KDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMY 665



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 62/224 (27%), Positives = 106/224 (47%), Gaps = 37/224 (16%)

Query: 231 LEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQ 290
           + K K KK+ KK+        HK   SSSSSSS S SSS +++S  SS+SES  +EK  +
Sbjct: 178 IPKSKVKKEEKKR--------HKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKK 229

Query: 291 RKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKP-------------- 336
           RKK+       H  +  + K + KKRK  ++ +SS    E  + +P              
Sbjct: 230 RKKK-------HRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPE 282

Query: 337 -RFLKHES--SREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRS- 392
            RFL  +S    ++ +  + + +++   +  + +    +R+   +RS GR+ + R  R  
Sbjct: 283 NRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRS-GRKIKGRGPRRY 341

Query: 393 RSPGSYKQRETRKRAQRNPGEEQSRRNDSR---SHGTDLYRGEK 433
           R+P   + R+  +R++  P   Q  +   R   S G    +G+K
Sbjct: 342 RTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDK 385



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 48/209 (22%), Positives = 96/209 (45%), Gaps = 21/209 (10%)

Query: 226 RKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNK 285
           R  + +++K+K+ D K K  ++SRSK K  +  S S+                 S+S  K
Sbjct: 492 RDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSN-------------EHDHSKSKEK 538

Query: 286 EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR 345
           +++ Q + R+ +   G ++ +S  +++S+ R     + S  H+R++++ K     H    
Sbjct: 539 DRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKE---YHRYRE 595

Query: 346 EDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRK 405
           ++ +       ++ RT       +   R+   SRS  REE    S+SR+   Y+ +E++ 
Sbjct: 596 QEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREE----SQSRNKDKYRNQESKS 651

Query: 406 RAQRNPGEEQSRR-NDSRSHGTDLYRGEK 433
             ++   E + R  + SR H +     EK
Sbjct: 652 SHRKENSESEKRMYSKSRDHNSSNNSREK 680



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 57/221 (25%), Positives = 97/221 (43%), Gaps = 19/221 (8%)

Query: 233 KKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNN-KEKKIQR 291
           ++ +   R + + +  RS+   H       +     SS E      +SE N  KE +   
Sbjct: 339 RRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSP 398

Query: 292 KKRKKNKCSGHNN---SDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDS 348
            + K+ K + H N   S + + +K KK K H+  S     R  +++  ++      R  S
Sbjct: 399 VRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKS 458

Query: 349 KWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGRE-----ERSRRS--------RSRSP 395
           K S S S +KS++ +   +   +E K   SRS GR+     E+ ++S        RSRS 
Sbjct: 459 K-SRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSK 517

Query: 396 GSYKQRETRKRA-QRNPGEEQSRRNDSRSHGTDLYRGEKMY 435
              KQ E++      +  +E+ RR  SRS   D+ +G+  Y
Sbjct: 518 EKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSY 558



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 62/302 (20%), Positives = 116/302 (38%), Gaps = 48/302 (15%)

Query: 193 NDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKH 252
           +D S +  +S    D E    +   +K+++K  RK  R  KK+KKK +K KK   S S+ 
Sbjct: 204 SDSSSDSQSSSDSSDSESATEEK--SKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEA 261

Query: 253 KKHKSSSSSSSSSSSSSSTETSE---SSSESESNNKEKKIQRKKRKKNKCSGHNN----- 304
           +  ++   S+           +      S  +++ KE+K  R++ ++ +C+  N+     
Sbjct: 262 ENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERK-NRERERERECNPPNSQPASY 320

Query: 305 ------SDSEEKDKSK-KRKLHEELSSSHHNREKAKEKPRFLKHESSR-------EDSKW 350
                 + S  K K +  R+      S   +R +  E P   + E  R          +W
Sbjct: 321 QRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERW 380

Query: 351 SHSD-----------------SDKKSRTHKH---SPEKRGSERKEGSSRSHGREERSRRS 390
              D                  ++K   H++   SP ++  + K+        +ER  R 
Sbjct: 381 IKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRR 440

Query: 391 RSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGE--KMYREHPGGTHTKVTQ 448
            S     YK +  +KRA+     +   ++ S+   +   R E  +M     G  H  V +
Sbjct: 441 NSEKDDKYKNK-VKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKE 499

Query: 449 RE 450
           +E
Sbjct: 500 KE 501



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 46/236 (19%), Positives = 99/236 (41%), Gaps = 18/236 (7%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKK---------KFQKSRSKHKKHKSSSSSSSSSSSSS 269
           K KQ   +  +    K K+KDR+ +         K + S +   + +S S   S    S 
Sbjct: 519 KSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSR 578

Query: 270 STETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNR 329
           + +   S S+     +E++ +R+ R +++        S  KD+ ++R+   +  SS    
Sbjct: 579 THDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRR---DSRSSEREE 635

Query: 330 EKAKEKPRFLKHESSREDSKWSHSDSDKK--SRTHKHSPEKRGSERKEGSSRS-HGREER 386
            +++ K ++ +++ S+   +  +S+S+K+  S++  H+      E+K    +S   + ++
Sbjct: 636 SQSRNKDKY-RNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQ 694

Query: 387 SRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGT 442
           S +         K +E  K       E Q  +     H  +  + +K   E   GT
Sbjct: 695 SSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHE--KNKKFDHESSPGT 748



 Score = 35.8 bits (81), Expect = 0.081
 Identities = 32/124 (25%), Positives = 50/124 (40%), Gaps = 11/124 (8%)

Query: 201 ASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDR--------KKKKFQKSRSKH 252
           +SE EE       K    + K    ++    EK+   K R        ++KK  + +S  
Sbjct: 630 SSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPF 689

Query: 253 KKHKSSSSSSSSSSSSSSTETSE---SSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEE 309
            K K SS  +   SS    +  E   SS E E+   + +      +KNK   H +S   +
Sbjct: 690 SKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTD 749

Query: 310 KDKS 313
           +DKS
Sbjct: 750 EDKS 753


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 65/218 (29%), Positives = 100/218 (45%), Gaps = 19/218 (8%)

Query: 226 RKLDRLEKKKKKKDRKK------KKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSE 279
           RK+  +E K   + R+           +SRS+H +   S S SS SS S S   S S S 
Sbjct: 168 RKIRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSR 227

Query: 280 SESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFL 339
           S S ++ +   R + KK K      S S  K+KS+ R  H    S   ++++A+EK    
Sbjct: 228 SRSKSRSRSQSRSRSKKEK------SRSPSKEKSRSRS-HSAGKSRSKSKDQAEEK--IQ 278

Query: 340 KHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGS---SRSHGREERSRRSRSRSPG 396
            +++  +    S S    KS++   S E+R  E K GS    RS  +  R  RSRSRS G
Sbjct: 279 NNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKG 338

Query: 397 SYKQRETRKRAQRNPGEEQSR-RNDSRSHGTDLYRGEK 433
             + R   +   ++  + + R R +SRS      + E+
Sbjct: 339 GSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSER 376



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 72/238 (30%), Positives = 104/238 (43%), Gaps = 19/238 (7%)

Query: 213 LKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTE 272
           ++ +  K   +  R   R     + + R +   +KSRS+    KSS S S S S S S  
Sbjct: 170 IRLVEDKPGSRRRRSYSRSRSHSRSRSRSRHS-RKSRSRSGSSKSSHSKSRSRSRSGSRS 228

Query: 273 TSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKA 332
            S+S S S+S ++ KK   K R  +K    + S S  K +SK +   EE   ++ N  K 
Sbjct: 229 RSKSRSRSQSRSRSKK--EKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKP 286

Query: 333 KEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRR--- 389
           K +        SR  SK   S S  +S+  +   EKRGS  +  S     R+ RSR    
Sbjct: 287 KSR------SPSRHKSK---SKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSK 337

Query: 390 --SRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTK 445
             SRSRS    K ++ RK  +R+  E +SR            RG K  R+   G+  K
Sbjct: 338 GGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSK--RDSKAGSSKK 393



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 60/223 (26%), Positives = 98/223 (43%), Gaps = 9/223 (4%)

Query: 203 EGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSS 262
           E    P  E  +S +    +   +  D+ E+K +  D   K   +S S+HK      S S
Sbjct: 245 EKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSK----SKS 300

Query: 263 SSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSK-KRKLHEE 321
            S S     E  +  S S   ++EK + R+ R +++  G + S S  + KSK KRK  + 
Sbjct: 301 RSRSQERRVEEEKRGSVSRGRSQEKSL-RQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKR 359

Query: 322 LSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSH 381
                 +R +++ K    +   S+ DSK   S   KK  T +   + R   R     R H
Sbjct: 360 SREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDR--SQSRSPSRSVSKEREH 417

Query: 382 GREERSRR-SRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
            + E S+R  R  S  +   +ETR R++ N   + +  ++SRS
Sbjct: 418 AKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRS 460



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 64/224 (28%), Positives = 100/224 (44%), Gaps = 34/224 (15%)

Query: 230 RLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKI 289
           R + + + + R + K +KSRS  K+   S S S+  S S S + +E   ++  N  + K 
Sbjct: 229 RSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKS 288

Query: 290 QRKKRKKNKCSGHNNSDS----EEKDKSKKRKLHEELS-------------SSHHNREKA 332
           +   R K+K    + S      EEK  S  R   +E S             S   +R ++
Sbjct: 289 RSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRS 348

Query: 333 KEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSER--KEGSSRSHGREERSR-- 388
           K K +    + SRE+S+     S  +SR+      KRGS+R  K GSS+   +E+  R  
Sbjct: 349 KSKDKRKGRKRSREESR-----SRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQ 403

Query: 389 -RSRSRSPGSYKQRETRKRAQR-------NPGEEQSRRNDSRSH 424
            RS SRS    ++    + +QR       N G  Q  R+ SRS+
Sbjct: 404 SRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSN 447



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 46/196 (23%), Positives = 88/196 (44%), Gaps = 14/196 (7%)

Query: 218 TKQKQKLLRKLDRLEKKKK----KKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTET 273
           +K K +   +  R+E++K+    +   ++K  ++SRS+ +    S S S S S S     
Sbjct: 296 SKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRK 355

Query: 274 SESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAK 333
               S  ES ++ +   R K ++++  G          K KK++  +   S   +R  +K
Sbjct: 356 GRKRSREESRSRSRS--RSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSK 413

Query: 334 EKPRFLKHESSRE---DSKWSHSDSDKKSRTHKHSPEK-----RGSERKEGSSRSHGREE 385
           E+       S RE   +S+ + ++ + +SR+  +S  K         R + +S++  R +
Sbjct: 414 EREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSK 473

Query: 386 RSRRSRSRSPGSYKQR 401
              RS SRSP   + R
Sbjct: 474 SRSRSASRSPSRSRSR 489


>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
           containing B [Homo sapiens]
          Length = 546

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 55/222 (24%), Positives = 97/222 (43%), Gaps = 22/222 (9%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSS 278
           K++Q+L R+    EK++++     +  ++ RS+ ++   S S S            E   
Sbjct: 299 KERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREK 358

Query: 279 ESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRF 338
           E+E   +  +   K+R         N   +E+++S++R   E+ S      +K KE    
Sbjct: 359 ENERGRRRDRDYDKER--------GNEREKERERSRERS-KEQRSRGEVEEKKHKEDKDD 409

Query: 339 LKHESSREDSKWSHSDSDKKSRTHKHSPEKRG----------SERKEGSSRSHGREERSR 388
            +H   + DSK     S  +SR  KH    R           S+ K    ++  +E+ ++
Sbjct: 410 RRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNK 469

Query: 389 RSRSRSPGSYKQRETRKRAQRNPGEEQSR---RNDSRSHGTD 427
           RSRS S G     E  K+ + +P +E+SR   R+  RSH  D
Sbjct: 470 RSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRD 511



 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 58/257 (22%), Positives = 107/257 (41%), Gaps = 29/257 (11%)

Query: 188 RNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQK 247
           R L      Q       E + E    +S+    +++  R  +R   + + +DRK  +  +
Sbjct: 293 RELEREKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDR 352

Query: 248 SRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKK----IQRKKRKKNKCSGHN 303
            R + K+++               E  +    S   +KE++    ++ KK K++K    +
Sbjct: 353 DREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRH 412

Query: 304 NSDSEEKDKSKK-------RKLHEELSSSHH----NREKAKEKPRFLKHESSREDSKWSH 352
             D  +  K KK        + H   S S +    +R ++KEK    K+ES  + +K S 
Sbjct: 413 RDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSR 472

Query: 353 S------DSDKKSRTHKHSPEKRGS-ERKEGSSRSHGREERSRRSRSRSPGSYKQRETRK 405
           S      DS +KS+  +HSP K  S +R     RSH R+    + +S        +  R+
Sbjct: 473 SGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQS-------DKHDRR 525

Query: 406 RAQRNPGEEQSRRNDSR 422
           R+Q    E Q +++ ++
Sbjct: 526 RSQSIEQESQEKQHKNK 542



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 57/249 (22%), Positives = 111/249 (44%), Gaps = 32/249 (12%)

Query: 207 DPEVEFLKSLTTKQKQKLLRKLDR-LEKKKKKKDRKKKKFQKS--RSKHKKHKSSSSSSS 263
           D +++       K  ++   ++DR +E+++ +  R+    ++S  RS+ + H      SS
Sbjct: 230 DQQIKTRPRKIKKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSS 289

Query: 264 SSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELS 323
           S       E      E E+  +EK+ +R+ R  ++      S S E+ +S+ R    +  
Sbjct: 290 SFDRELEREKERQRLEREAKEREKE-RRRSRSIDRGLERRRSRSRERHRSRSRS--RDRK 346

Query: 324 SSHHNREKAKEK------------------PRFLKHESSREDSKWSHSDSDKKSRTHK-- 363
               +R++ +EK                   R  + E SRE SK   S  + + + HK  
Sbjct: 347 GDRRDRDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKED 406

Query: 364 -----HSPEKRGSERKEGSSRSHGREERSR-RSRSRSPGSYKQRETRKRAQRNPGEEQSR 417
                H  +KR S++++  SRS  RE + R RSRSR+ G   +  +++++ ++  E + +
Sbjct: 407 KDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEK 466

Query: 418 RNDSRSHGT 426
            N     G+
Sbjct: 467 SNKRSRSGS 475



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 48/230 (20%), Positives = 102/230 (44%), Gaps = 7/230 (3%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSS 278
           +++++  R +DR  ++++ + R++ +  +SRS+ +K             +      +   
Sbjct: 312 EKERRRSRSIDRGLERRRSRSRERHR-SRSRSRDRKGDRRDRDREREKENERGRRRDRDY 370

Query: 279 ESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKK--RKLHEELSSSHHNREKAKEKP 336
           + E  N+ +K + + R+++K         E+K K  K  R+  ++   S   ++ ++ + 
Sbjct: 371 DKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRS 430

Query: 337 RFLKHES---SREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSR 393
           R  KH S   SR   K S S S +KS  HK+  +++ ++R    S+         + R  
Sbjct: 431 RERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREH 490

Query: 394 SPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTH 443
           SP   K R+  +  +R+   + S   D +S   D  R + + +E     H
Sbjct: 491 SPSKEKSRKRSRSKERSHKRDHSDSKD-QSDKHDRRRSQSIEQESQEKQH 539



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 50/169 (29%), Positives = 83/169 (49%), Gaps = 22/169 (13%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSS 278
           ++K+    K DR  +  K+  +K+KK  +SRS+ +KH+S S S ++   S S  + E SS
Sbjct: 399 EEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRS-RSKEKSS 457

Query: 279 ESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRF 338
           + ++ +KEK       K+++      +DS EK  SKKR+         H+  K K + R 
Sbjct: 458 KHKNESKEKS-----NKRSRSGSQGRTDSVEK--SKKRE---------HSPSKEKSRKRS 501

Query: 339 LKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERS 387
              E S    K  HSDS  K ++ KH   +  S  +E   + H  ++ +
Sbjct: 502 RSKERSH---KRDHSDS--KDQSDKHDRRRSQSIEQESQEKQHKNKDET 545



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 35/126 (27%), Positives = 64/126 (50%), Gaps = 8/126 (6%)

Query: 218 TKQKQKLLRKLDRLEK-KKKKKDRKKKKFQKSRSKHK--KHKSSSSSSSS----SSSSSS 270
           +K+++K  R   R  K + + + R   K  +SRSK K  KHK+ S   S+    S S   
Sbjct: 419 SKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGR 478

Query: 271 TETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDS-EEKDKSKKRKLHEELSSSHHNR 329
           T++ E S + E +  ++K +++ R K +    ++SDS ++ DK  +R+       S   +
Sbjct: 479 TDSVEKSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQ 538

Query: 330 EKAKEK 335
            K K++
Sbjct: 539 HKNKDE 544



 Score = 30.4 bits (67), Expect = 3.4
 Identities = 20/98 (20%), Positives = 45/98 (45%), Gaps = 5/98 (5%)

Query: 214 KSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKS---RSKHKKHKSSSSSS--SSSSSS 268
           K   ++ K+K  +  +  ++K  K+ R   + +     +SK ++H  S   S   S S  
Sbjct: 446 KRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKEKSRKRSRSKE 505

Query: 269 SSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSD 306
            S +   S S+ +S+  +++  +   ++++   H N D
Sbjct: 506 RSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543


>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
          Length = 248

 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 55/203 (27%), Positives = 100/203 (49%), Gaps = 16/203 (7%)

Query: 202 SEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSS 261
           +E EE     + K L  K ++KLL   +   KK+++K ++KK            KS  SS
Sbjct: 59  AEFEEKMNENWKKELE-KSREKLLSGNESSSKKRERKKKRKK------------KSCRSS 105

Query: 262 SSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDK-SKKRKLHE 320
           SSSSSS SS+ +S+S  E +   K +K ++ +  K+  S  + S+SE K+   KK+K  +
Sbjct: 106 SSSSSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKSKD 165

Query: 321 ELSSSHHNREKAKEKPRFLKHES--SREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSS 378
           E       R  +K++ +    +   S E S  S  + D +++  +   E+  ++ K    
Sbjct: 166 ETEKEKDVRSLSKKRKKSYPDDKPLSSESSSESDYEEDVQAKKKRRCEEREQAKEKVKKK 225

Query: 379 RSHGREERSRRSRSRSPGSYKQR 401
           +    ++ S++ + +S  S+K R
Sbjct: 226 KKKQHKKHSKKKKKKSGSSHKSR 248



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 46/216 (21%), Positives = 85/216 (39%), Gaps = 3/216 (1%)

Query: 229 DRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKK 288
           D L + +   +  KK+ +  ++  K   +      + +     E S     S + +  KK
Sbjct: 32  DYLNRPRPTWEEVKKQLENKKTGSKA-LAEFEEKMNENWKKELEKSREKLLSGNESSSKK 90

Query: 289 IQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDS 348
            +RKK++K K S  ++S S   D S      E+       R K K+   +   +SS  +S
Sbjct: 91  RERKKKRKKK-SCRSSSSSSSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQSSTHES 149

Query: 349 KWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHG-REERSRRSRSRSPGSYKQRETRKRA 407
           +    +S KK +  K   EK    R     R     +++   S S S   Y++    K+ 
Sbjct: 150 ESESKESVKKKKKSKDETEKEKDVRSLSKKRKKSYPDDKPLSSESSSESDYEEDVQAKKK 209

Query: 408 QRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTH 443
           +R    EQ++    +       +  K  ++  G +H
Sbjct: 210 RRCEEREQAKEKVKKKKKKQHKKHSKKKKKKSGSSH 245



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 41/147 (27%), Positives = 65/147 (44%), Gaps = 7/147 (4%)

Query: 191 TANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRS 250
           +++D S     SE EE  + +  K    +  +         E + K+  +KKKK +    
Sbjct: 109 SSSDSSSSSSDSEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESKESVKKKKKSKDETE 168

Query: 251 KHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEK 310
           K K  +S S     S       +SESSSES+    E+ +Q K  KK +C       ++EK
Sbjct: 169 KEKDVRSLSKKRKKSYPDDKPLSSESSSESD---YEEDVQAK--KKRRC--EEREQAKEK 221

Query: 311 DKSKKRKLHEELSSSHHNREKAKEKPR 337
            K KK+K H++ S     +  +  K R
Sbjct: 222 VKKKKKKQHKKHSKKKKKKSGSSHKSR 248


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 76.6 bits (187), Expect = 4e-14
 Identities = 49/222 (22%), Positives = 94/222 (42%), Gaps = 25/222 (11%)

Query: 226 RKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNK 285
           RK +R E++K+K++R+K++ ++   K KK +                  E   E E   K
Sbjct: 36  RKKERREREKRKREREKERKRERGKKEKKKRKKR---------------ERGKERERKRK 80

Query: 286 EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR 345
           E++ QRK+R+          + E + + K++K  E        R+K KE+    +    R
Sbjct: 81  EREKQRKERR----------EKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQR 130

Query: 346 EDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRK 405
            + K       K+ +  K   E+   ERK    +   RE++  R+R       +++E R+
Sbjct: 131 RERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRE 190

Query: 406 RAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTKVT 447
           R +    E + ++   +   TD     +++R        +VT
Sbjct: 191 RKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFNRVT 232



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 46/192 (23%), Positives = 88/192 (45%), Gaps = 9/192 (4%)

Query: 232 EKKKKKKDRKKKKFQKSRS-KHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQ 290
           E+KK++++R+K+K ++ +  K ++ K               E      E +   + +K +
Sbjct: 35  ERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKER 94

Query: 291 RKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKW 350
           RK++K+ K          E+ K K+RK  E  +     R++ K + +  + E  RE  + 
Sbjct: 95  RKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER- 153

Query: 351 SHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRN 410
              +  +K R  +   +KR   RKE   R   RE + RR R +     +++E RK+ +R 
Sbjct: 154 GKRERKRKKRKKEEREKKRERNRKE---RKKERERKERRERKKE----RKKERRKKKERK 206

Query: 411 PGEEQSRRNDSR 422
              +  R+ DS+
Sbjct: 207 KDRKTDRQTDSQ 218



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 42/170 (24%), Positives = 72/170 (42%), Gaps = 25/170 (14%)

Query: 269 SSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHN 328
           S +  S+  ++ ES  K+++ +R+KRK+            E++K +KR+           
Sbjct: 21  SCSHISKPCTQRESERKKERREREKRKR------------EREKERKRE--------RGK 60

Query: 329 REKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREER-S 387
           +EK K K R         + K    +  +K R  K    KR  E+K+   +  GR ER  
Sbjct: 61  KEKKKRKKR---ERGKERERKRKEREKQRKERREKER-RKRKKEKKKRERKQRGRRERKK 116

Query: 388 RRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
           ++ R       KQR  RKR +R   + +  R   +  G    + +K  +E
Sbjct: 117 KKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKE 166



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/133 (23%), Positives = 55/133 (41%), Gaps = 7/133 (5%)

Query: 319 HEELSSSHHNREKAKEKPRFLKHESSRE-DSKWSHSDSDKKSRTHKHSPEKRGSERKEGS 377
           H     +    E+ KE+    K +  RE + K      +KK R  +   ++R  +RKE  
Sbjct: 24  HISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKERE 83

Query: 378 SRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
            +   R E+ RR R       K+++ R+R QR   E + ++        +  R E+  ++
Sbjct: 84  KQRKERREKERRKRK------KEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKK 137

Query: 438 HPGGTHTKVTQRE 450
                  K  +RE
Sbjct: 138 RRKKKRRKERKRE 150


>gi|38146107 arginine/serine-rich coiled-coil 2 isoform a [Homo
           sapiens]
          Length = 434

 Score = 75.5 bits (184), Expect = 9e-14
 Identities = 71/217 (32%), Positives = 95/217 (43%), Gaps = 21/217 (9%)

Query: 229 DRLEKKKKKKDRKKKKFQKSRS---KHKKHKSSSSSSSSSSSSSSTETSESSSESESNNK 285
           D L  +K   DR KKK Q   S   +  KH  S S S S      ++       S S +K
Sbjct: 9   DGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNEGRKHRSRSRSK 68

Query: 286 EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR 345
           E +    K K +K   H + +  +K+ S   K  E L+SS +  ++ K K R    +SSR
Sbjct: 69  EGRRHESKDKSSK--KHKSEEHNDKEHSSD-KGRERLNSSENGEDRHKRKER----KSSR 121

Query: 346 EDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRK 405
             S   HS S  + R H+     R  ERK+  SRS  R++   RSR R     + RE RK
Sbjct: 122 GRS---HSRSRSRERRHR----SRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRE-RK 173

Query: 406 RAQRNPGEEQSR---RNDSRSHGTDLYRGEKMYREHP 439
           R  R+    +SR   R  SRS      R  K   E P
Sbjct: 174 RRIRSRSRSRSRHRHRTRSRSRTRSRSRDRKKRIEKP 210



 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 57/192 (29%), Positives = 95/192 (49%), Gaps = 21/192 (10%)

Query: 236 KKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRK 295
           + + R +++ +KS ++ +KH+S S S       S  ++S+     E N+KE    + + +
Sbjct: 42  RSRSRSRERKRKSDNEGRKHRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRER 101

Query: 296 KNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDS 355
            N     ++ + E++ K K+RK     S   H+R +++E+    +H S   + K S S  
Sbjct: 102 LN-----SSENGEDRHKRKERKSSRGRS---HSRSRSRER----RHRSRSRERKKSRS-- 147

Query: 356 DKKSRTHKHSPEKRGSERKEGSSRSHGREERSR-RSRSRSPGSYKQR---ETRKRAQRNP 411
             +SR  K S   R  ERK+  SRS  R+ R R RSRSRS   ++ R    TR R++   
Sbjct: 148 --RSRERKKS-RSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSRDRK 204

Query: 412 GEEQSRRNDSRS 423
              +  R  SRS
Sbjct: 205 KRIEKPRRFSRS 216



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 53/187 (28%), Positives = 86/187 (45%), Gaps = 24/187 (12%)

Query: 267 SSSSTETSESSSESESNNKEKKIQRKKRKKN-KCSGHNNSDSEEKDKSKKRKLHEELSSS 325
           ++S TE    + E  S +++KK ++ +   + + S H+ S S  + + +KRK   E    
Sbjct: 2   AASDTERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERKRKSDNE-GRK 60

Query: 326 HHNREKAKEKPRF-LKHESSREDSKWSHSD----SDK--------KSRTHKHSPEKRGSE 372
           H +R ++KE  R   K +SS++     H+D    SDK        ++   +H  ++R S 
Sbjct: 61  HRSRSRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSS 120

Query: 373 RKEGSSRSHGREERSR---------RSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
           R    SRS  RE R R         RSRSR     + R   ++  R+   E+ RR  SRS
Sbjct: 121 RGRSHSRSRSRERRHRSRSRERKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRS 180

Query: 424 HGTDLYR 430
                +R
Sbjct: 181 RSRSRHR 187



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 65/255 (25%), Positives = 104/255 (40%), Gaps = 53/255 (20%)

Query: 182 KRNVLGRNLTANDPSQEYVASEGEEDPEVE---FLKSLTTKQKQKLLRKLDRLEKKKKKK 238
           +R+ L    T+ D  ++   SE    P      + +S +  +++K  RK D   +K + +
Sbjct: 7   ERDGLAPEKTSPDRDKKKEQSEVSVSPRASKHHYSRSRSRSRERK--RKSDNEGRKHRSR 64

Query: 239 DRKK--KKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESS------------------S 278
            R K  ++ +      KKHKS   +    SS    E   SS                  S
Sbjct: 65  SRSKEGRRHESKDKSSKKHKSEEHNDKEHSSDKGRERLNSSENGEDRHKRKERKSSRGRS 124

Query: 279 ESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRF 338
            S S ++E++ + + R++ K    + S S E+ KS+ R           +RE+ K + R 
Sbjct: 125 HSRSRSRERRHRSRSRERKK----SRSRSRERKKSRSR-----------SRERKKSRSR- 168

Query: 339 LKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRR-----SRSR 393
                SRE  +   S S  +SR H+H    R   R     R   R E+ RR     SR+ 
Sbjct: 169 -----SRERKRRIRSRSRSRSR-HRHRTRSRSRTRSRSRDRKK-RIEKPRRFSRSLSRTP 221

Query: 394 SPGSYKQRETRKRAQ 408
           SP  ++ R T   AQ
Sbjct: 222 SPPPFRGRNTAMDAQ 236



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 33/124 (26%), Positives = 61/124 (49%), Gaps = 15/124 (12%)

Query: 226 RKLDRLEKKKKKKDRKK-KKFQKSRSKHKKHKSSSSSSSSSSSSSSTET-SESSSESESN 283
           RK  R   +++KK R + ++ +KSRS+ ++ K    S S S S     T S S + S S 
Sbjct: 142 RKKSRSRSRERKKSRSRSRERKKSRSRSRERKRRIRSRSRSRSRHRHRTRSRSRTRSRSR 201

Query: 284 NKEKKIQRKKRKKNKCS---------GHNNS-DSEE---KDKSKKRKLHEELSSSHHNRE 330
           +++K+I++ +R     S         G N + D++E   +   + +KL E+       ++
Sbjct: 202 DRKKRIEKPRRFSRSLSRTPSPPPFRGRNTAMDAQEALARRLERAKKLQEQREKEMVEKQ 261

Query: 331 KAKE 334
           K +E
Sbjct: 262 KQQE 265


>gi|4759100 splicing factor, arginine/serine-rich 11 [Homo sapiens]
          Length = 484

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 59/262 (22%), Positives = 116/262 (44%), Gaps = 11/262 (4%)

Query: 180 ALKRNVLGRNLTANDPSQEYVASEGEEDPEVEF-LKSLTTKQKQKLLRKLDRLEKKKKKK 238
           +L  + L + ++  DP   +VA+ G   P ++    S   ++  K +R+   L     + 
Sbjct: 181 SLAADQLLKLMSTVDPKLNHVAA-GLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEP 239

Query: 239 DRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKK----- 293
           D+K++K + SRS+ +  +  + SSS    S S     S S+S S  + K  +R++     
Sbjct: 240 DKKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRE 299

Query: 294 --RKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWS 351
             R+    S   +   E+K+K + +   +  S++  +R  ++E+ R      +R   K  
Sbjct: 300 RGRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKK-P 358

Query: 352 HSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNP 411
            S   K SR+      K+  ++ +   RS    ERS   + +S    K RE +  + ++ 
Sbjct: 359 RSPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDV 418

Query: 412 GEEQSRRNDSRSHGTDLYRGEK 433
            ++ +R  D    G D  + +K
Sbjct: 419 -KQVTRDYDEEEQGYDSEKEKK 439



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 49/171 (28%), Positives = 78/171 (45%), Gaps = 13/171 (7%)

Query: 230 RLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKI 289
           R     K +D+KK+  +K RSK       S S++  S S+S E     S S + + +K  
Sbjct: 303 RSRSTSKTRDKKKEDKEKKRSKTPP---KSYSTARRSRSASRERRRRRSRSGTRSPKKPR 359

Query: 290 QRKKRKKNKCSGHNNSDSEEKDKSKKRKLHE-ELSSSHHNREKAKEKPRFLKHESSRE-- 346
             K++     S   +   ++KDK K+R   E E S+S   + K KEK R  K ES ++  
Sbjct: 360 SPKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVK 419

Query: 347 ------DSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSR 391
                 D +    DS+K+ +  K  P + GS + +  S   G  +  R S+
Sbjct: 420 QVTRDYDEEEQGYDSEKEKKEEK-KPIETGSPKTKECSVEKGTGDSLRESK 469



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 32/147 (21%), Positives = 64/147 (43%), Gaps = 8/147 (5%)

Query: 217 TTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSES 276
           T+K + K  +K D+ +K+ K   +     ++SRS  ++ +   S S + S          
Sbjct: 307 TSKTRDK--KKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRSPKRK 364

Query: 277 SSESESNNKEKKIQRKKRKKNKC------SGHNNSDSEEKDKSKKRKLHEELSSSHHNRE 330
            S S S  + KK ++K + K +       S      S++K+K ++RK   +       R+
Sbjct: 365 LSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQVTRD 424

Query: 331 KAKEKPRFLKHESSREDSKWSHSDSDK 357
             +E+  +   +  +E+ K   + S K
Sbjct: 425 YDEEEQGYDSEKEKKEEKKPIETGSPK 451



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 31/118 (26%), Positives = 49/118 (41%), Gaps = 8/118 (6%)

Query: 221 KQKLLRKLD-RLEKKKKKKDRKKKKF--QKSRSKHKKHKSSSSSSSSSSSSSSTE----- 272
           K+KL R    R  KK+KKKD+ K++   ++ RS  KK KS          S S +     
Sbjct: 362 KRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQV 421

Query: 273 TSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNRE 330
           T +   E +  + EK+ + +K+     S      S EK      +  +     HH  +
Sbjct: 422 TRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEED 479



 Score = 36.2 bits (82), Expect = 0.062
 Identities = 27/105 (25%), Positives = 47/105 (44%), Gaps = 3/105 (2%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSES-S 277
           K+++K  +  +R   ++++   KKKK  K + K ++ KS S       +    E  +   
Sbjct: 375 KKEKKKDKDKERSRDERERSTSKKKK-SKDKEKDRERKSESDKDVKQVTRDYDEEEQGYD 433

Query: 278 SESESNNKEKKIQRKKRKKNKCSGHNNS-DSEEKDKSKKRKLHEE 321
           SE E   ++K I+    K  +CS    + DS  + K      HEE
Sbjct: 434 SEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEE 478


>gi|42741684 zinc finger protein 265 isoform 1 [Homo sapiens]
          Length = 330

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 58/192 (30%), Positives = 85/192 (44%), Gaps = 18/192 (9%)

Query: 202 SEGEEDPEVEFLKSLTTKQKQKL----LRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKS 257
           SEGEE+ E E L      + +      L K + L+  +++   KKK  ++SRSK +   S
Sbjct: 153 SEGEEEDEDEDLSKYKLDEDEDEDDADLSKYN-LDASEEEDSNKKKSNRRSRSKSRSSHS 211

Query: 258 SSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRK 317
            SSS SSS SSS + +   S  S S+    +   ++R +++ S   +S    +  S  RK
Sbjct: 212 RSSSRSSSPSSSRSRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGSSSPRK 271

Query: 318 LHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGS 377
                SSS   R +             R  S+ S S   KK RT   SPE+R      GS
Sbjct: 272 RSYSSSSSSPERNR------------KRSRSRSSSSGDRKKRRTRSRSPERR-HRSSSGS 318

Query: 378 SRSHGREERSRR 389
           S S  R    ++
Sbjct: 319 SHSGSRSSSKKK 330



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 68/232 (29%), Positives = 102/232 (43%), Gaps = 25/232 (10%)

Query: 198 EYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRL-EKKKKKKDRKKKKFQKSRSKHKKHK 256
           EY+  E E D E +       K + K +     L E + K+ + +++   +  SK+K  +
Sbjct: 113 EYIERE-ESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDEDEDLSKYKLDE 171

Query: 257 SSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKR 316
                 +  S  +       +SE E +NK KK  R+ R K++ S H+ S S     S  R
Sbjct: 172 DEDEDDADLSKYNL-----DASEEEDSNK-KKSNRRSRSKSR-SSHSRSSSRSSSPSSSR 224

Query: 317 KLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEG 376
                  S   +R ++    +     SSRE S+   S S   SR+H+ S     S RK  
Sbjct: 225 -------SRSRSRSRSSSSSQSRSRSSSRERSRSRGSKSRSSSRSHRGS----SSPRKRS 273

Query: 377 SSRSHGREERSR---RSRSRSPGSYKQRETRKRA--QRNPGEEQSRRNDSRS 423
            S S    ER+R   RSRS S G  K+R TR R+  +R+     S  + SRS
Sbjct: 274 YSSSSSSPERNRKRSRSRSSSSGDRKKRRTRSRSPERRHRSSSGSSHSGSRS 325



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 58/217 (26%), Positives = 96/217 (44%), Gaps = 17/217 (7%)

Query: 234 KKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKK 293
           ++++ D +  +F + + K++      +S         +E  E   E E  +K K  + + 
Sbjct: 116 EREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESE-GEEEDEDEDLSKYKLDEDED 174

Query: 294 RKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHS 353
                 S +N   SEE+D +KK+      S S  +  ++  +        SR  S+ S S
Sbjct: 175 EDDADLSKYNLDASEEEDSNKKKSNRRSRSKSRSSHSRSSSRSSSPSSSRSRSRSR-SRS 233

Query: 354 DSDKKSRTHKHSPEK---RGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQ-- 408
            S  +SR+   S E+   RGS+ +  SSRSH R   S R RS S  S      RKR++  
Sbjct: 234 SSSSQSRSRSSSRERSRSRGSKSRS-SSRSH-RGSSSPRKRSYSSSSSSPERNRKRSRSR 291

Query: 409 -RNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHT 444
             + G+ + RR  SRS        E+ +R   G +H+
Sbjct: 292 SSSSGDRKKRRTRSRS-------PERRHRSSSGSSHS 321



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 41/168 (24%), Positives = 71/168 (42%), Gaps = 32/168 (19%)

Query: 272 ETSESSSESESNNKEKKIQRKKRK-KNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNRE 330
           E  E     ES+ +  +  RKK+K + K  G  +   E +DK  + +  +E      + +
Sbjct: 110 ENVEYIEREESDGEYDEFGRKKKKYRGKAVGPASILKEVEDKESEGEEEDE------DED 163

Query: 331 KAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRS 390
            +K K   L  +   +D+  S  + D        + E+  S +K+ +          RRS
Sbjct: 164 LSKYK---LDEDEDEDDADLSKYNLD--------ASEEEDSNKKKSN----------RRS 202

Query: 391 RSRSPGSYKQRETRKRAQRNPGEEQSR-RNDSRSHGTDLYRGEKMYRE 437
           RS+S  S+ +  +R     +P   +SR R+ SRS  +   R     RE
Sbjct: 203 RSKSRSSHSRSSSR---SSSPSSSRSRSRSRSRSSSSSQSRSRSSSRE 247


>gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]
          Length = 237

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 46/190 (24%), Positives = 91/190 (47%), Gaps = 14/190 (7%)

Query: 211 EFLKSLTTKQKQKLLRKLDRL----EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSS 266
           EF + +    K++L +  ++L    E   KK+ RKKK+        KK     SSSSSSS
Sbjct: 50  EFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKE--------KKKSGRYSSSSSSS 101

Query: 267 SSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSH 326
           S SS+ +S+S  E +   K +K ++ +  K+  S  + ++S+ KD  KK+K  ++ +   
Sbjct: 102 SDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKE 161

Query: 327 HNREKAKEKPRFLKHESSREDSKWSHSD--SDKKSRTHKHSPEKRGSERKEGSSRSHGRE 384
            + +   +K +    +        S S+   + +++  K S E+  +  K    + H + 
Sbjct: 162 KDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKH 221

Query: 385 ERSRRSRSRS 394
            + ++ ++ S
Sbjct: 222 SKKKKKKAAS 231



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 60/185 (32%), Positives = 85/185 (45%), Gaps = 24/185 (12%)

Query: 202 SEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKK-KKKDRKKKKFQKSRSKHKKHKSSSS 260
           +E EE     + K L  K ++KLL   +   KK+ +KK  KKK       ++    SSSS
Sbjct: 49  AEFEEKMNENWKKELE-KHREKLLSGSESSSKKRQRKKKEKKKS-----GRYSSSSSSSS 102

Query: 261 SSSSSSSSSSTE-------------TSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDS 307
            SSSSSS S  E              S  SSES  +  E   +   +KK K       + 
Sbjct: 103 DSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEK 162

Query: 308 EEKDKSKKRKLHEE---LSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKH 364
           + K  SKKRK++ E   LSS   +  +  E+ R  K +SS E  K +   + KK +  KH
Sbjct: 163 DIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREK-ATEKTKKKKKHKKH 221

Query: 365 SPEKR 369
           S +K+
Sbjct: 222 SKKKK 226



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 17/133 (12%)

Query: 229 DRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKK 288
           D  ++ KK+  R+KKK      K++ HKSS SS S + S S     +     +   KEK 
Sbjct: 110 DSEDEDKKQGKRRKKK------KNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKD 163

Query: 289 IQ--RKKRK----KNKCSGHNNSDSE--EKDKSKKRKLHEELSSSHHNREKAKEKPRFLK 340
           I+   KKRK        S  + S+SE  E+ ++KK+K  EE   +    EK K+K +  K
Sbjct: 164 IKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKA---TEKTKKKKKHKK 220

Query: 341 HESSREDSKWSHS 353
           H   ++    S S
Sbjct: 221 HSKKKKKKAASSS 233



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 35/121 (28%), Positives = 55/121 (45%), Gaps = 2/121 (1%)

Query: 287 KKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR- 345
           K+   KK+K +K          E  K +  K  E+L S   +  K +++ +  K +S R 
Sbjct: 35  KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 94

Query: 346 EDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERS-RRSRSRSPGSYKQRETR 404
             S  S SDS   S   +   +K+G  RK+  +RSH   E S   + S S  S K+++  
Sbjct: 95  SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKS 154

Query: 405 K 405
           K
Sbjct: 155 K 155



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 33/91 (36%), Positives = 45/91 (49%), Gaps = 12/91 (13%)

Query: 229 DRLEKKKKKKD-RKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSE-------SSSE- 279
           D L+KKKK KD  +K+K  K  SK +K  S     SS S S S    E       SS E 
Sbjct: 146 DSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEER 205

Query: 280 ---SESNNKEKKIQRKKRKKNKCSGHNNSDS 307
              +E   K+KK ++  +KK K +  ++ DS
Sbjct: 206 EKATEKTKKKKKHKKHSKKKKKKAASSSPDS 236



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 36/150 (24%), Positives = 67/150 (44%), Gaps = 15/150 (10%)

Query: 187 GRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQ 246
           GR  +++  S +  +S  + + E +  +    K+K+    K       + + D K    +
Sbjct: 92  GRYSSSSSSSSDSSSSSSDSEDE-DKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK 150

Query: 247 KSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSD 306
           K +SK    K       S      +E    SSES S ++  +  R K+KK       +S+
Sbjct: 151 KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKK-------SSE 203

Query: 307 SEEK--DKSKKRKLHEELSSSHHNREKAKE 334
             EK  +K+KK+K H++     H+++K K+
Sbjct: 204 EREKATEKTKKKKKHKK-----HSKKKKKK 228



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 54/245 (22%), Positives = 94/245 (38%), Gaps = 50/245 (20%)

Query: 29  EQKISYDKKK---------QEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAK 79
           E K   +KKK         +E++ + + KE E +  +LL G E               +K
Sbjct: 33  EVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSES-------------SSK 79

Query: 80  KENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNT 139
           K  ++K+E +    Y       +     + D  +  D+  G + R  +  + HK      
Sbjct: 80  KRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSED-EDKKQGKR-RKKKKNRSHK------ 131

Query: 140 DRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEY 199
                    S  ++ S     S  S+   +        G   ++++ G +      S++ 
Sbjct: 132 ---------SSESSMSETESDSKDSLKKKK----KSKDGTEKEKDIKGLSKKRKMYSEDK 178

Query: 200 VASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSS 259
             S  E   E E+++ +  K+K+    +    EK KKKK  KK       SK KK K++S
Sbjct: 179 PLSS-ESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKK------HSKKKKKKAAS 231

Query: 260 SSSSS 264
           SS  S
Sbjct: 232 SSPDS 236



 Score = 33.9 bits (76), Expect = 0.31
 Identities = 14/46 (30%), Positives = 25/46 (54%)

Query: 228 LDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTET 273
           ++ +  KKKK   +++K  +   K KKHK  S      ++SSS ++
Sbjct: 191 IEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 236



 Score = 33.5 bits (75), Expect = 0.40
 Identities = 25/137 (18%), Positives = 49/137 (35%), Gaps = 7/137 (5%)

Query: 308 EEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPE 367
           ++K  SK     EE  + +  +E  K + + L    S    +       KKS  +  S  
Sbjct: 40  KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSS 99

Query: 368 KRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTD 427
                    S      +++ +R + +   S+K  E+      +  ++  ++      GT+
Sbjct: 100 SSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 159

Query: 428 -------LYRGEKMYRE 437
                  L +  KMY E
Sbjct: 160 KEKDIKGLSKKRKMYSE 176


>gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]
          Length = 247

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 46/190 (24%), Positives = 91/190 (47%), Gaps = 14/190 (7%)

Query: 211 EFLKSLTTKQKQKLLRKLDRL----EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSS 266
           EF + +    K++L +  ++L    E   KK+ RKKK+        KK     SSSSSSS
Sbjct: 60  EFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKE--------KKKSGRYSSSSSSS 111

Query: 267 SSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSH 326
           S SS+ +S+S  E +   K +K ++ +  K+  S  + ++S+ KD  KK+K  ++ +   
Sbjct: 112 SDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKE 171

Query: 327 HNREKAKEKPRFLKHESSREDSKWSHSD--SDKKSRTHKHSPEKRGSERKEGSSRSHGRE 384
            + +   +K +    +        S S+   + +++  K S E+  +  K    + H + 
Sbjct: 172 KDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKKH 231

Query: 385 ERSRRSRSRS 394
            + ++ ++ S
Sbjct: 232 SKKKKKKAAS 241



 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 60/185 (32%), Positives = 85/185 (45%), Gaps = 24/185 (12%)

Query: 202 SEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKK-KKKDRKKKKFQKSRSKHKKHKSSSS 260
           +E EE     + K L  K ++KLL   +   KK+ +KK  KKK       ++    SSSS
Sbjct: 59  AEFEEKMNENWKKELE-KHREKLLSGSESSSKKRQRKKKEKKKS-----GRYSSSSSSSS 112

Query: 261 SSSSSSSSSSTE-------------TSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDS 307
            SSSSSS S  E              S  SSES  +  E   +   +KK K       + 
Sbjct: 113 DSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEK 172

Query: 308 EEKDKSKKRKLHEE---LSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKH 364
           + K  SKKRK++ E   LSS   +  +  E+ R  K +SS E  K +   + KK +  KH
Sbjct: 173 DIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREK-ATEKTKKKKKHKKH 231

Query: 365 SPEKR 369
           S +K+
Sbjct: 232 SKKKK 236



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 17/133 (12%)

Query: 229 DRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKK 288
           D  ++ KK+  R+KKK      K++ HKSS SS S + S S     +     +   KEK 
Sbjct: 120 DSEDEDKKQGKRRKKK------KNRSHKSSESSMSETESDSKDSLKKKKKSKDGTEKEKD 173

Query: 289 IQ--RKKRK----KNKCSGHNNSDSE--EKDKSKKRKLHEELSSSHHNREKAKEKPRFLK 340
           I+   KKRK        S  + S+SE  E+ ++KK+K  EE   +    EK K+K +  K
Sbjct: 174 IKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEEREKA---TEKTKKKKKHKK 230

Query: 341 HESSREDSKWSHS 353
           H   ++    S S
Sbjct: 231 HSKKKKKKAASSS 243



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 35/121 (28%), Positives = 55/121 (45%), Gaps = 2/121 (1%)

Query: 287 KKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR- 345
           K+   KK+K +K          E  K +  K  E+L S   +  K +++ +  K +S R 
Sbjct: 45  KEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRY 104

Query: 346 EDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERS-RRSRSRSPGSYKQRETR 404
             S  S SDS   S   +   +K+G  RK+  +RSH   E S   + S S  S K+++  
Sbjct: 105 SSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKS 164

Query: 405 K 405
           K
Sbjct: 165 K 165



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 33/91 (36%), Positives = 45/91 (49%), Gaps = 12/91 (13%)

Query: 229 DRLEKKKKKKD-RKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSE-------SSSE- 279
           D L+KKKK KD  +K+K  K  SK +K  S     SS S S S    E       SS E 
Sbjct: 156 DSLKKKKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKKSSEER 215

Query: 280 ---SESNNKEKKIQRKKRKKNKCSGHNNSDS 307
              +E   K+KK ++  +KK K +  ++ DS
Sbjct: 216 EKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 36/150 (24%), Positives = 67/150 (44%), Gaps = 15/150 (10%)

Query: 187 GRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQ 246
           GR  +++  S +  +S  + + E +  +    K+K+    K       + + D K    +
Sbjct: 102 GRYSSSSSSSSDSSSSSSDSEDE-DKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKK 160

Query: 247 KSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSD 306
           K +SK    K       S      +E    SSES S ++  +  R K+KK       +S+
Sbjct: 161 KKKSKDGTEKEKDIKGLSKKRKMYSEDKPLSSESLSESEYIEEVRAKKKK-------SSE 213

Query: 307 SEEK--DKSKKRKLHEELSSSHHNREKAKE 334
             EK  +K+KK+K H++     H+++K K+
Sbjct: 214 EREKATEKTKKKKKHKK-----HSKKKKKK 238



 Score = 34.7 bits (78), Expect = 0.18
 Identities = 54/245 (22%), Positives = 94/245 (38%), Gaps = 50/245 (20%)

Query: 29  EQKISYDKKK---------QEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAK 79
           E K   +KKK         +E++ + + KE E +  +LL G E               +K
Sbjct: 43  EVKEQLEKKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSES-------------SSK 89

Query: 80  KENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNT 139
           K  ++K+E +    Y       +     + D  +  D+  G + R  +  + HK      
Sbjct: 90  KRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSED-EDKKQGKR-RKKKKNRSHK------ 141

Query: 140 DRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEY 199
                    S  ++ S     S  S+   +        G   ++++ G +      S++ 
Sbjct: 142 ---------SSESSMSETESDSKDSLKKKK----KSKDGTEKEKDIKGLSKKRKMYSEDK 188

Query: 200 VASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSS 259
             S  E   E E+++ +  K+K+    +    EK KKKK  KK       SK KK K++S
Sbjct: 189 PLSS-ESLSESEYIEEVRAKKKKSSEEREKATEKTKKKKKHKK------HSKKKKKKAAS 241

Query: 260 SSSSS 264
           SS  S
Sbjct: 242 SSPDS 246



 Score = 33.9 bits (76), Expect = 0.31
 Identities = 14/46 (30%), Positives = 25/46 (54%)

Query: 228 LDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTET 273
           ++ +  KKKK   +++K  +   K KKHK  S      ++SSS ++
Sbjct: 201 IEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAASSSPDS 246



 Score = 33.5 bits (75), Expect = 0.40
 Identities = 25/137 (18%), Positives = 49/137 (35%), Gaps = 7/137 (5%)

Query: 308 EEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPE 367
           ++K  SK     EE  + +  +E  K + + L    S    +       KKS  +  S  
Sbjct: 50  KKKKGSKALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSS 109

Query: 368 KRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTD 427
                    S      +++ +R + +   S+K  E+      +  ++  ++      GT+
Sbjct: 110 SSSDSSSSSSDSEDEDKKQGKRRKKKKNRSHKSSESSMSETESDSKDSLKKKKKSKDGTE 169

Query: 428 -------LYRGEKMYRE 437
                  L +  KMY E
Sbjct: 170 KEKDIKGLSKKRKMYSE 186


>gi|52426743 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 56/227 (24%), Positives = 112/227 (49%), Gaps = 33/227 (14%)

Query: 197 QEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHK--- 253
           +E +    EE    E LK    K+KQ+   +    E+++++++RK+++ ++ R K +   
Sbjct: 231 KEKLRKRTEEPDRDERLK----KEKQEREEREKEREREREERERKRRREEEEREKERARD 286

Query: 254 --KHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKD 311
             + K S S S  SS +S    S S     S ++E++ + + R + +   H+ S+ + + 
Sbjct: 287 RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERR-RSRSRDRRRSRSHDRSERKHRS 345

Query: 312 KSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGS 371
           +S+ R+           R K++++  + KH S   D      + D+KS+      EKRGS
Sbjct: 346 RSRDRR-----------RSKSRDRKSY-KHRSKSRD-----REQDRKSK----EKEKRGS 384

Query: 372 ERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQ--RNPGEEQS 416
           + K+ S +S  RE++S  + + S  S  + E    ++  ++ G+ QS
Sbjct: 385 DDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQS 431



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 39/151 (25%), Positives = 76/151 (50%), Gaps = 6/151 (3%)

Query: 280 SESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFL 339
           +E  +++++++++K+++ +       + EE+++ ++R+  E       +RE+ K      
Sbjct: 238 TEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRS 297

Query: 340 KHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYK 399
           +H S   D + S S   K+SR+ +    +R   R    SRSH R ER  RSRSR     K
Sbjct: 298 RHSSRTSDRRCSRSRDHKRSRSRE---RRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSK 354

Query: 400 QRETR--KRAQRNPGEEQSRRN-DSRSHGTD 427
            R+ +  K   ++   EQ R++ +    G+D
Sbjct: 355 SRDRKSYKHRSKSRDREQDRKSKEKEKRGSD 385



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 34/141 (24%), Positives = 58/141 (41%), Gaps = 10/141 (7%)

Query: 287 KKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSRE 346
           ++++ K RK+ +       + +  ++ KK K   E       RE+ + + +  + E  RE
Sbjct: 228 EELKEKLRKRTE-------EPDRDERLKKEKQEREEREKEREREREERERKRRREEEERE 280

Query: 347 DSKWSHSDSDKKSRT---HKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRET 403
             +    +  K+SR+   H      R   R     RS  RE R  RSR R       R  
Sbjct: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340

Query: 404 RKRAQRNPGEEQSRRNDSRSH 424
           RK   R+    +S+  D +S+
Sbjct: 341 RKHRSRSRDRRRSKSRDRKSY 361



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 56/259 (21%), Positives = 105/259 (40%), Gaps = 17/259 (6%)

Query: 190 LTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSR 249
           L+ N  S       G+ + +++ L    T +   LL++++ L  + K ++ +       +
Sbjct: 109 LSQNQQSSGAAGPTGKNEEKIQVL----TDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQ 164

Query: 250 SKHKKHKSSSSSSSSSSSSSSTETSESSSESES----NNKEKKIQRKKRKKNKCSGHNNS 305
            K ++    S++S+  S ++  +  E      +     + + ++      K         
Sbjct: 165 LKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIK 224

Query: 306 DSEEKDKSKKRKLHEELSSSHH-NREKAKEKPRFLKHESSRED---SKWSHSDSDKKSRT 361
            + E+ K K RK  EE        +EK + + R  + E  RE+    +    +  +K R 
Sbjct: 225 ATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERA 284

Query: 362 HKHSPEKRGSERKEGSSRSHGRE-ERSR---RSRSRSPGSYKQRETRKRAQRNPGEEQSR 417
                 KR   R   SSR+  R   RSR   RSRSR     + R+ R+R++ +   E+  
Sbjct: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRD-RRRSRSHDRSERKH 343

Query: 418 RNDSRSHGTDLYRGEKMYR 436
           R+ SR       R  K Y+
Sbjct: 344 RSRSRDRRRSKSRDRKSYK 362



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 59/275 (21%), Positives = 98/275 (35%), Gaps = 56/275 (20%)

Query: 18  SKSNIKKVWMAEQKISYDKKKQ--EELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAP 75
           ++S +    M +Q + Y K K   EEL ++  K  E  D      DER+K       E  
Sbjct: 204 AQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDR-----DERLKKEKQEREERE 258

Query: 76  PGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWG 135
              ++E +E+E      E + E ++   RE                  R  R     +  
Sbjct: 259 KEREREREERERKRRREEEEREKERARDRE------------------RRKRSRSRSRHS 300

Query: 136 HVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDP 195
              +DR C                 S    H      E R S     R+   R   ++D 
Sbjct: 301 SRTSDRRC-----------------SRSRDHKRSRSRERRRS-----RSRDRRRSRSHDR 338

Query: 196 SQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKH 255
           S+    S   +    +     + K + K          + +++DRK K+ +K  S  KK 
Sbjct: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSK---------SRDREQDRKSKEKEKRGSDDKKS 389

Query: 256 KSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQ 290
              S S    S  ++TE+ ES +++E N   + I+
Sbjct: 390 SVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424


>gi|19923485 cisplatin resistance-associated overexpressed protein
           [Homo sapiens]
          Length = 432

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 56/227 (24%), Positives = 112/227 (49%), Gaps = 33/227 (14%)

Query: 197 QEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHK--- 253
           +E +    EE    E LK    K+KQ+   +    E+++++++RK+++ ++ R K +   
Sbjct: 231 KEKLRKRTEEPDRDERLK----KEKQEREEREKEREREREERERKRRREEEEREKERARD 286

Query: 254 --KHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKD 311
             + K S S S  SS +S    S S     S ++E++ + + R + +   H+ S+ + + 
Sbjct: 287 RERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERR-RSRSRDRRRSRSHDRSERKHRS 345

Query: 312 KSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGS 371
           +S+ R+           R K++++  + KH S   D      + D+KS+      EKRGS
Sbjct: 346 RSRDRR-----------RSKSRDRKSY-KHRSKSRD-----REQDRKSK----EKEKRGS 384

Query: 372 ERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQ--RNPGEEQS 416
           + K+ S +S  RE++S  + + S  S  + E    ++  ++ G+ QS
Sbjct: 385 DDKKSSVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIKSEGDTQS 431



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 39/151 (25%), Positives = 76/151 (50%), Gaps = 6/151 (3%)

Query: 280 SESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFL 339
           +E  +++++++++K+++ +       + EE+++ ++R+  E       +RE+ K      
Sbjct: 238 TEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERARDRERRKRSRSRS 297

Query: 340 KHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYK 399
           +H S   D + S S   K+SR+ +    +R   R    SRSH R ER  RSRSR     K
Sbjct: 298 RHSSRTSDRRCSRSRDHKRSRSRE---RRRSRSRDRRRSRSHDRSERKHRSRSRDRRRSK 354

Query: 400 QRETR--KRAQRNPGEEQSRRN-DSRSHGTD 427
            R+ +  K   ++   EQ R++ +    G+D
Sbjct: 355 SRDRKSYKHRSKSRDREQDRKSKEKEKRGSD 385



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 34/141 (24%), Positives = 58/141 (41%), Gaps = 10/141 (7%)

Query: 287 KKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSRE 346
           ++++ K RK+ +       + +  ++ KK K   E       RE+ + + +  + E  RE
Sbjct: 228 EELKEKLRKRTE-------EPDRDERLKKEKQEREEREKEREREREERERKRRREEEERE 280

Query: 347 DSKWSHSDSDKKSRT---HKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRET 403
             +    +  K+SR+   H      R   R     RS  RE R  RSR R       R  
Sbjct: 281 KERARDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRDRRRSRSHDRSE 340

Query: 404 RKRAQRNPGEEQSRRNDSRSH 424
           RK   R+    +S+  D +S+
Sbjct: 341 RKHRSRSRDRRRSKSRDRKSY 361



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 56/259 (21%), Positives = 105/259 (40%), Gaps = 17/259 (6%)

Query: 190 LTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSR 249
           L+ N  S       G+ + +++ L    T +   LL++++ L  + K ++ +       +
Sbjct: 109 LSQNQQSSGAAGPTGKNEEKIQVL----TDKIDVLLQQIEELGSEGKVEEAQGMMKLVEQ 164

Query: 250 SKHKKHKSSSSSSSSSSSSSSTETSESSSESES----NNKEKKIQRKKRKKNKCSGHNNS 305
            K ++    S++S+  S ++  +  E      +     + + ++      K         
Sbjct: 165 LKEERELLRSTTSTIESFAAQEKQMEVCEVCGAFLIVGDAQSRVDDHLMGKQHMGYAKIK 224

Query: 306 DSEEKDKSKKRKLHEELSSSHH-NREKAKEKPRFLKHESSRED---SKWSHSDSDKKSRT 361
            + E+ K K RK  EE        +EK + + R  + E  RE+    +    +  +K R 
Sbjct: 225 ATVEELKEKLRKRTEEPDRDERLKKEKQEREEREKEREREREERERKRRREEEEREKERA 284

Query: 362 HKHSPEKRGSERKEGSSRSHGRE-ERSR---RSRSRSPGSYKQRETRKRAQRNPGEEQSR 417
                 KR   R   SSR+  R   RSR   RSRSR     + R+ R+R++ +   E+  
Sbjct: 285 RDRERRKRSRSRSRHSSRTSDRRCSRSRDHKRSRSRERRRSRSRD-RRRSRSHDRSERKH 343

Query: 418 RNDSRSHGTDLYRGEKMYR 436
           R+ SR       R  K Y+
Sbjct: 344 RSRSRDRRRSKSRDRKSYK 362



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 59/275 (21%), Positives = 98/275 (35%), Gaps = 56/275 (20%)

Query: 18  SKSNIKKVWMAEQKISYDKKKQ--EELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAP 75
           ++S +    M +Q + Y K K   EEL ++  K  E  D      DER+K       E  
Sbjct: 204 AQSRVDDHLMGKQHMGYAKIKATVEELKEKLRKRTEEPDR-----DERLKKEKQEREERE 258

Query: 76  PGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWG 135
              ++E +E+E      E + E ++   RE                  R  R     +  
Sbjct: 259 KEREREREERERKRRREEEEREKERARDRE------------------RRKRSRSRSRHS 300

Query: 136 HVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDP 195
              +DR C                 S    H      E R S     R+   R   ++D 
Sbjct: 301 SRTSDRRC-----------------SRSRDHKRSRSRERRRS-----RSRDRRRSRSHDR 338

Query: 196 SQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKH 255
           S+    S   +    +     + K + K          + +++DRK K+ +K  S  KK 
Sbjct: 339 SERKHRSRSRDRRRSKSRDRKSYKHRSK---------SRDREQDRKSKEKEKRGSDDKKS 389

Query: 256 KSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQ 290
              S S    S  ++TE+ ES +++E N   + I+
Sbjct: 390 SVKSGSREKQSEDTNTESKESDTKNEVNGTSEDIK 424


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 39/201 (19%), Positives = 87/201 (43%), Gaps = 1/201 (0%)

Query: 203 EGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSS 262
           E E D + +  +    +++Q   ++  R E+ ++ + +++++ ++ R + +  K      
Sbjct: 263 ERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERE 322

Query: 263 SSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEEL 322
                    ET E   E E   K K+     R++N+ +G       E+++ ++R+   + 
Sbjct: 323 RERERERQRET-ERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQS 381

Query: 323 SSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHG 382
           +     RE+ +++ R  + E   E  +    +++K+    K    +RG ER     +  G
Sbjct: 382 AREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGREREKQKG 441

Query: 383 REERSRRSRSRSPGSYKQRET 403
           RE    R   R  G  ++R T
Sbjct: 442 RERDRERQTDRQAGRQRKRST 462



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 38/212 (17%), Positives = 90/212 (42%)

Query: 226 RKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNK 285
           R+ DR   ++++K+R ++K ++  ++ +  +     +           +E   E +++ +
Sbjct: 107 RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRE 166

Query: 286 EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR 345
            ++   + R+K +    N  +  E+++ ++++   E   S   RE+ +E+    + E  R
Sbjct: 167 RQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKR 226

Query: 346 EDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRK 405
           +  +        +    K +  +R SER+    +   RE    R R R     +++  RK
Sbjct: 227 QTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRK 286

Query: 406 RAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
           R +R   + ++ R   R    +  R     RE
Sbjct: 287 RQRRTERDRETERKRERQRERERERERNRKRE 318



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 43/232 (18%), Positives = 104/232 (44%), Gaps = 8/232 (3%)

Query: 203 EGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSS 262
           E E   + E  +   T ++++   + +R ++++++K+R++++ ++ R + K++K+    S
Sbjct: 148 ERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERR-ERERQREKENKTEDRHS 206

Query: 263 SSSSSSSSTETSESSSESE-SNNKEKKIQRK-KRKKNKCSGHNNSDSEEKDKSKKRKLHE 320
                      +E+ +E +   ++E+  QRK +R++ K +    +   E ++ K+R+   
Sbjct: 207 ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERER 266

Query: 321 ELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRS 380
           +       R+K +E+    K +   E  + +    +++    +     R  ER+    R 
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERE 326

Query: 381 HGREERSRRSRSRSPGSYKQRETRKRAQRN-----PGEEQSRRNDSRSHGTD 427
             R+  + R R +     ++R+T    +RN      G  Q+ R   R    D
Sbjct: 327 RERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERD 378



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 41/203 (20%), Positives = 85/203 (41%), Gaps = 17/203 (8%)

Query: 253 KKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDK 312
           ++   S  S        + + ++      +  KE++ +R+KR+  + +        EKD+
Sbjct: 28  RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDR 87

Query: 313 SKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSE 372
            +KR  H E       R++ KE+ R    E  R+  K  +   +++  T +    +RG +
Sbjct: 88  HRKRDRHRE-----RQRDREKERERQTDRERDRQREKERNRQKERERETEREG--ERGRD 140

Query: 373 RKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRR----------NDSR 422
           R+    R   R+  + + R R     +QR+T +  Q+    E++R+           +++
Sbjct: 141 RQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENK 200

Query: 423 SHGTDLYRGEKMYREHPGGTHTK 445
           +      RG +  RE    T T+
Sbjct: 201 TEDRHSERGRERERERETETETE 223



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 57/283 (20%), Positives = 111/283 (39%), Gaps = 22/283 (7%)

Query: 189 NLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDR-------- 240
           N T +  S+     E E + E E  +   T +++   RK +R  +K+ +++R        
Sbjct: 199 NKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETER 258

Query: 241 -KKKKFQKSRSK-----HKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKR 294
            K+++ ++ R +      K+ +  +       +    ET           +E++  RK+ 
Sbjct: 259 DKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRE 318

Query: 295 KKNKCSGHNNSDSE-----EKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSK 349
           ++ +         E     EK++ +KRK   E+     NR+  +E  R  + E  RE  +
Sbjct: 319 RERERERERERQRETERDREKERERKRKRQTEM-DRERNRQTGREGRRQAERERERERER 377

Query: 350 WSHSDSDKKSRTHKHSPEK-RGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQ 408
              S  +++ R      ++ +  ER+    R   RE   +R R +   S + RE  +  +
Sbjct: 378 DRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDRESERGRERGRERE 437

Query: 409 RNPGEEQSR-RNDSRSHGTDLYRGEKMYREHPGGTHTKVTQRE 450
           +  G E+ R R   R  G    R        P    + V Q +
Sbjct: 438 KQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSD 480



 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 47/242 (19%), Positives = 107/242 (44%), Gaps = 23/242 (9%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSS 278
           ++K++  R+ DR  +++++KDR +K     R +H++ +          +    +      
Sbjct: 66  REKRQTERETDRKRERRREKDRHRK-----RDRHRERQRDREKERERQTDRERDRQREKE 120

Query: 279 ESESNNKEKKIQRK-KRKKNKCSGHNNSDSEEKDKSKKRKLH---EELSSSHHNREKAKE 334
            +    +E++ +R+ +R +++ +        ++D  K+R+     E    +  NR+K +E
Sbjct: 121 RNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERE 180

Query: 335 KPRFLKHESSREDSKWSHSDSDKKSRTH-KHSPEKRGSERKEGSSRSHGREERSRRSRSR 393
           +      E +R++ +      +K+++T  +HS   R  ER+  +     R+ ++ R R R
Sbjct: 181 R------EKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDR 234

Query: 394 SPGSYKQRETRKRAQRNPGEEQSRRND-----SRSHGTDLYRGEKMYREHPGGTHTKVTQ 448
              + ++RE  K+A+R    E+    D      R    D  R +K           + T+
Sbjct: 235 QRKTERERE--KQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292

Query: 449 RE 450
           R+
Sbjct: 293 RD 294



 Score = 62.8 bits (151), Expect = 6e-10
 Identities = 44/241 (18%), Positives = 98/241 (40%), Gaps = 23/241 (9%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDR---------KKKKFQKSRSKHKKHKSSSSSSSSSSSSS 269
           +Q++K  +  DR  ++ ++++R         +K++  + R + +K +      +    +S
Sbjct: 193 RQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERAS 252

Query: 270 STETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNR 329
             ET          ++++   R+++++ + +        E+D+  +RK   +       R
Sbjct: 253 ERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQ-----RER 307

Query: 330 EKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRR 389
           E+ +E+ R  + E  RE  +    ++++     +    KR +E     +R  GRE R + 
Sbjct: 308 ERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQA 367

Query: 390 SRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTKVTQR 449
            R        +RE  +   R    E+  R   R       R  +  ++  G   T+  QR
Sbjct: 368 ER--------ERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETE-KQR 418

Query: 450 E 450
           E
Sbjct: 419 E 419



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 52/252 (20%), Positives = 104/252 (41%), Gaps = 34/252 (13%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDR-------------------KKKKFQKSRSKHKKHKSSS 259
           K +Q+   +  + EK+ K +DR                   +K++  + R + +K +   
Sbjct: 183 KNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQRKTERER 242

Query: 260 SSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLH 319
              +    +S  ET          ++++   R+++++ + +        E+D+  +RK  
Sbjct: 243 EKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRE 302

Query: 320 EELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSR 379
            +       RE+ +E+ R  + E  RE  +    ++++     +    KR +E     +R
Sbjct: 303 RQ-----RERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEMDRERNR 357

Query: 380 SHGRE-----ERSR-RSRSRSPGSYKQRETRKR-AQRNPGEEQSRRNDSRSHG---TDLY 429
             GRE     ER R R R R   S ++RE R+R   R+  +E+ R+ +    G   T+  
Sbjct: 358 QTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQ 417

Query: 430 RGEKMYREHPGG 441
           R  +  RE   G
Sbjct: 418 REREKDRESERG 429



 Score = 59.7 bits (143), Expect = 5e-09
 Identities = 50/246 (20%), Positives = 111/246 (45%), Gaps = 20/246 (8%)

Query: 203 EGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKF-------QKSRSKHKKH 255
           E + D E E  +    ++ ++  ++ +R ++++++ +R+ ++        Q+ R + +  
Sbjct: 96  ERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDA 155

Query: 256 KSSSSSSSSSSSSSSTETS-ESSSESESNNKEKK-IQRKKRKKNKCSGHNNSDSEEKDKS 313
           +      +       TE + +   E E N +E++  +R++ K+NK    ++    E+++ 
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERE 215

Query: 314 KKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSER 373
           ++ +   E       R+  +E+ R  K E  RE      ++ ++ S       ++R  ER
Sbjct: 216 RETETETE-----RKRQTDRERDRQRKTERERE----KQAERERASERETERDKERERER 266

Query: 374 KEGSSRSHGREERSRRS-RSRSPGSYKQRET-RKRAQRNPGEEQSRRNDSRSHGTDLYRG 431
                R   ++ER R++ R R   + + RET RKR ++   E +  RN  R    +  R 
Sbjct: 267 DRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERE 326

Query: 432 EKMYRE 437
            +  RE
Sbjct: 327 RERQRE 332



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 33/196 (16%), Positives = 87/196 (44%), Gaps = 3/196 (1%)

Query: 226 RKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNK 285
           R+ D   ++++++D +K++ +++  + ++    +         +  E  E   + E  NK
Sbjct: 141 RQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENK 200

Query: 286 EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR 345
            +    ++ ++ +      +++E K ++ + +  +    +   REK  E+ R  + E+ R
Sbjct: 201 TEDRHSERGRERERERETETETERKRQTDRER--DRQRKTEREREKQAERERASERETER 258

Query: 346 EDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRK 405
           +  +    D D + R  +    +R ++RK        RE   +R R R     ++R  ++
Sbjct: 259 DKERERERDRD-RDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKR 317

Query: 406 RAQRNPGEEQSRRNDS 421
             +R    E+ R+ ++
Sbjct: 318 ERERERERERERQRET 333



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 41/219 (18%), Positives = 92/219 (42%), Gaps = 16/219 (7%)

Query: 229 DRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETS-ESSSESESNNKEK 287
           DR   ++K+++R+++K Q  R   +K +               E   +   E E     +
Sbjct: 53  DRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRE 112

Query: 288 KIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSRED 347
           + +++++++N+          E ++ + R+     +     RE+ ++  +  + ++ RE 
Sbjct: 113 RDRQREKERNRQKERERETEREGERGRDRQ-----TDGQRERERQRDAEKERERQTDRER 167

Query: 348 SKWSHSDSDKKSRTHKHSPEKRGSER-KEGSSRSHGREERSRRSRSRSPGSYKQRETRKR 406
            + +  +  K+    K+  E+R  ER +E  +++  R     R R R      +RET   
Sbjct: 168 QRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERER------ERETETE 221

Query: 407 AQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTK 445
            +R   + Q+ R   R   T+  R ++  RE      T+
Sbjct: 222 TER---KRQTDRERDRQRKTEREREKQAERERASERETE 257


>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
          Length = 1564

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 99/420 (23%), Positives = 157/420 (37%), Gaps = 56/420 (13%)

Query: 60  GDERVKNGLNFMYEAPPGAKKENKEKEETEGETE-------YKFEWQKGAPREKYAKDDM 112
           G  R K  +    E  P +++EN E E    +++       Y  E      R+K  ++ M
Sbjct: 119 GRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELM 178

Query: 113 NIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIA 172
            +  +   ++ R    IK      V   +  P   L    +S  P   S P    +    
Sbjct: 179 KLEQE--NMEKREEIIIKKEVSPEVVRSKLSPSPSLR--KSSKSPKRKSSPKSSSASK-K 233

Query: 173 EMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLE 232
           + + S  +       RN   N   ++   +     P  E + +L  K K+K   K DR+E
Sbjct: 234 DRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDI-ALGKKYKEKYKVK-DRIE 291

Query: 233 KKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRK 292
           +K +    + + F++ R K  K +S+S +    S  SS   S SS    S  +     R+
Sbjct: 292 EKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRR 351

Query: 293 K----------------RKKNKCSGHNNSDSEEKD---------KSKKRKLHEELSSSHH 327
           K                R  +    H+ S  + K          + K R  HE  S SH 
Sbjct: 352 KRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQRKQSPPRHRSPMREKGRHDHERTSQSHD 411

Query: 328 NREKAKEKPRFL--KHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREE 385
            R + +E  R    + + SRE+ ++    S   SR H+   E R     +G  R   R+ 
Sbjct: 412 RRHERREDTRGKRDREKDSREEREYEQDQS--SSRDHRDDREPR-----DGRDRRDARDT 464

Query: 386 RSRRSRSRSPGSYKQRETR-----KRAQRNPGEEQSRR--NDSRS-HGTDLYRGEKMYRE 437
           R RR    S      RE R      +  R+P + +S R  +D R   G D +R E  Y E
Sbjct: 465 RDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPE 524



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 44/204 (21%), Positives = 91/204 (44%), Gaps = 12/204 (5%)

Query: 226 RKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNK 285
           R++DR++ ++ ++ R++ + ++ R + ++ +               E   +        K
Sbjct: 663 RRVDRVDDRRDERARERDR-ERERDRERERERERERDREREKERELERERAREREREREK 721

Query: 286 EKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSR 345
           E+    ++R +++          E+D+ K+R+   E       RE+ +E+ R  + E +R
Sbjct: 722 ERD---RERDRDRDHDRERERERERDREKEREREREERERERERERERERERERERERAR 778

Query: 346 EDSK--WSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRET 403
           E  K      D + K +      EKR   R++ + R  G +ER  + R R+ GS   R++
Sbjct: 779 ERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRD-GHDERKSKKRYRNEGSPSPRQS 837

Query: 404 RKRAQRNPGEEQSRRNDSRSHGTD 427
            KR +     E S  +D+ + G D
Sbjct: 838 PKRRR-----EHSPDSDAYNSGDD 856



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 38/198 (19%), Positives = 86/198 (43%), Gaps = 6/198 (3%)

Query: 229 DRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKK 288
           DR  ++  +   +   F++ R   +  + +       SS    +      E +   +E++
Sbjct: 606 DRYPERDNRDQARDSSFER-RHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERR 664

Query: 289 IQRKKRKKNKCSGHNNSDSE---EKDKSKKRKLHEELSSSHH-NREKAKEKPRFLKHESS 344
           + R   ++++ +   + + E   E+++ ++R+   E        RE+A+E+ R  + E  
Sbjct: 665 VDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKERD 724

Query: 345 REDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETR 404
           RE  +    D +++    +   ++R  ER+E   R   RE    R R R     ++R+  
Sbjct: 725 RERDRDRDHDRERERERERDREKEREREREE-RERERERERERERERERERERARERDKE 783

Query: 405 KRAQRNPGEEQSRRNDSR 422
           +  QR+  ++   R+D R
Sbjct: 784 RERQRDWEDKDKGRDDRR 801



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 52/234 (22%), Positives = 102/234 (43%), Gaps = 32/234 (13%)

Query: 203 EGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSS 262
           E E D E E       +++++  R+ +R  +++++++R++++ +++R + K+ +      
Sbjct: 740 ERERDREKE-------REREREERERERERERERERERERER-ERARERDKERERQRDWE 791

Query: 263 SSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEEL 322
                             + N ++   +RK +K+ +    N      +   K+R+ H   
Sbjct: 792 DKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYR----NEGSPSPRQSPKRRREHSPD 847

Query: 323 SSSHHNREKAKEKPRFLKHESSREDSKW---SHSDSDKKSRTHKHSPEKRGSERKEGSSR 379
           S ++++ +   EK R L      ++S+    SH   D++ R  +   E R  ERKE S R
Sbjct: 848 SDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKE---EDRKPERKESSRR 904

Query: 380 SHGREERSRRSRSRSPGSYKQRE-------TRKRAQRNPGEEQS--RRNDSRSH 424
              +E + + S        KQRE       +R RAQ   G  QS  R    R+H
Sbjct: 905 YEEQELKEKVS-----SVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAH 953



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 48/267 (17%), Positives = 102/267 (38%), Gaps = 23/267 (8%)

Query: 187 GRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQ 246
           GRN    + S+  + +E   +   E        +  ++ R   R+ +  +K  R  +  Q
Sbjct: 530 GRNHLREESSRTEIRNESRNESRSEI-------RNDRMGRSRGRVPELPEKGSRGSRGSQ 582

Query: 247 -KSRSKHKKHKSSSSSSSS-------SSSSSSTETSESSSESESNNKEKKIQRKK--RKK 296
             S S +  +  S  + SS           +  +  +SS E     ++++  R++  R  
Sbjct: 583 IDSHSSNSNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPS 642

Query: 297 NKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSD 356
           +       +D  E+D+ ++ +  + +      R + +++ R    E  RE  +    + +
Sbjct: 643 SPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRERE 702

Query: 357 KKSRTHKHSPEKRGSERKE------GSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRN 410
           K+    +    +R  ER++         R H RE    R R R     ++RE R+R +  
Sbjct: 703 KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762

Query: 411 PGEEQSRRNDSRSHGTDLYRGEKMYRE 437
             E +  R   R    +  +  +  R+
Sbjct: 763 ERERERERERERERARERDKERERQRD 789



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 47/228 (20%), Positives = 96/228 (42%), Gaps = 18/228 (7%)

Query: 203 EGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSS 262
           E E D E E  +     ++++  R+L+R   ++++++R+K++  + R + + H       
Sbjct: 682 ERERDRERERERERERDREREKERELERERAREREREREKER-DRERDRDRDHDRERERE 740

Query: 263 SSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNS-----DSEEKDKSK--K 315
                    E      E E   + ++ + ++R++ +    +       D E+KDK +  +
Sbjct: 741 RERDREKEREREREERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDR 800

Query: 316 RKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKE 375
           R+  EE+    + R+   E     +    R  ++ S S      R  +HSP+       +
Sbjct: 801 REKREEIREDRNPRDGHDE-----RKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGD 855

Query: 376 GSSRSH---GREERSRRSRSRSPGSY-KQRETR-KRAQRNPGEEQSRR 418
             +  H    +  R + SRS SP    + R+ R K   R P  ++S R
Sbjct: 856 DKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSR 903



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 42/207 (20%), Positives = 74/207 (35%), Gaps = 7/207 (3%)

Query: 232 EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQR 291
           E+  +  DR+ ++ + +R K  + K S          SS+       E       +  + 
Sbjct: 404 ERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQSSSRDHRDDREPRDGRDRRDARD 463

Query: 292 KKRKKNKCSGHNNSDSEE-KDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKW 350
            + ++      +  DS E +D S+  K   +   S   R+    + R  +    +ED+  
Sbjct: 464 TRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYP 523

Query: 351 SHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRN 410
             S S  ++   + S            SRS  R +R  RSR R P      E  ++  R 
Sbjct: 524 EESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVP------ELPEKGSRG 577

Query: 411 PGEEQSRRNDSRSHGTDLYRGEKMYRE 437
               Q   + S S+  D +     Y E
Sbjct: 578 SRGSQIDSHSSNSNYHDSWETRSSYPE 604



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 58/292 (19%), Positives = 108/292 (36%), Gaps = 27/292 (9%)

Query: 173 EMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVE--FLKSLTTKQKQKLLRKLDR 230
           EMR+     K +   R+  +   + +Y   EG +    E  + +   +  +  L  +  R
Sbjct: 481 EMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLREESSR 540

Query: 231 LEKKKKKKDRKKKKFQKSRSKHKKHK--------SSSSSSSSSSSSSSTETSESSSESES 282
            E + + ++  + + +  R    + +        S  S  S   S SS      S E+ S
Sbjct: 541 TEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWETRS 600

Query: 283 NNKEKKIQRKKRKKNKCSGHNNSDSE---EKDKSKKRKLHEELSSSHHNREKAKEKPRFL 339
           +  E+   R   + N+    ++S      E+D+   R+  +  SS   ++ +  E    L
Sbjct: 601 SYPER--DRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDE----L 654

Query: 340 KHESSREDSKWSHSDSDKKSRTHKHSPEK-RGSERKEGSSRSHGREERSRRSRSRSPGSY 398
           + +  RE+ +    D  +  R  +   E+ R  ER+    R   RE    R   R     
Sbjct: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERARE 714

Query: 399 KQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREHPGGTHTKVTQRE 450
           ++RE  K   R        R+  R H  +  R  +  RE       +  +RE
Sbjct: 715 REREREKERDRE-------RDRDRDHDRERERERERDREKEREREREERERE 759



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 54/253 (21%), Positives = 99/253 (39%), Gaps = 39/253 (15%)

Query: 200  VASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSS 259
            V   G  D E      +T ++K ++    D+L     K+    +     R   + H S  
Sbjct: 1227 VLHSGSRDREKTKSLEITGERKSRI----DQL-----KRGEPSRSTSSDRQDSRSHSSRR 1277

Query: 260  SSSSSS----SSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKK 315
            SS  S     S S S ++ +   E +    +++ +R++R   +     ++D +      +
Sbjct: 1278 SSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDR 1337

Query: 316  RKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDK-KSRTHKHSPEKRGSERK 374
             +L E        RE+ ++K R L  E  R  S     D D+ + RT + S   +    K
Sbjct: 1338 DRLRE------RERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESS---QIESVK 1388

Query: 375  EGSSRSHGREERSRRSRSRSP------------GSYKQRETRKRAQR----NPGEEQSRR 418
               ++  G  ER   S SR              GS +  E   +++R      G+++S+ 
Sbjct: 1389 RCEAKLEGEHERDLESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKL 1448

Query: 419  NDSRSHGTDLYRG 431
            +D+ S G+    G
Sbjct: 1449 DDAHSLGSGAGEG 1461



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 43/189 (22%), Positives = 82/189 (43%), Gaps = 9/189 (4%)

Query: 197  QEYVASEGEEDPEVEFLKSLTTKQKQKL-LRKLDRLEKKKKKKDRKKKKFQKSRSKHKKH 255
            +E V+S  ++  + E L+S   + +  +   + +  E   +  D  KKK +  +   KK 
Sbjct: 911  KEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKK 970

Query: 256  KSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNN-SDSEEKDKSK 314
            K         +  +++E  +  S  +   K+K I++K++K     G ++ SD E   +SK
Sbjct: 971  KEDDVGIERGNIETTSEDGQVFSPKKGQ-KKKSIEKKRKK---SKGDSDISDEEAAQQSK 1026

Query: 315  KRK--LHEELSSSHHNREKAKEKPRFLKHESSREDSKWSH-SDSDKKSRTHKHSPEKRGS 371
            K++      +++     E    K   L+    +ED+ +S  SD D   RT     E   +
Sbjct: 1027 KKRGPRTPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTAT 1086

Query: 372  ERKEGSSRS 380
                GS+ S
Sbjct: 1087 ATTPGSTPS 1095



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 46/178 (25%), Positives = 69/178 (38%), Gaps = 31/178 (17%)

Query: 250  SKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEE 309
            ++H+K      SSS  S+ S+   +     S SN+               S H + D + 
Sbjct: 1178 AQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSND---------------SAHRSGDDQS 1222

Query: 310  KDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKR 369
                +KR LH    S   +REK K     L+    R+    S  D  K+    + +   R
Sbjct: 1223 ---GRKRVLH----SGSRDREKTKS----LEITGERK----SRIDQLKRGEPSRSTSSDR 1267

Query: 370  GSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTD 427
               R   S RS    +R   SRS S  S  + + R R + +   E+ RR D+R    D
Sbjct: 1268 QDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERR-DTRQREWD 1324



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 42/196 (21%), Positives = 78/196 (39%), Gaps = 16/196 (8%)

Query: 226  RKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSS--------SSSSTETSESS 277
            RK  R   +K +      +  + R    + +SSS  S+ S+         S S +++  S
Sbjct: 1158 RKCHRTRVEKVETPHVTIEDAQHRKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRS 1217

Query: 278  SESESNNK----EKKIQRKKRKKNKCSGHNNSDSEE---KDKSKKRKLHEELSSSHHNRE 330
             + +S  K         R+K K  + +G   S  ++    + S+      + S SH +R 
Sbjct: 1218 GDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRR 1277

Query: 331  KAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRS 390
             + E  R +   S   DS+    + D+     +   E+R + ++E   R   ++    R 
Sbjct: 1278 SSPESDRQVHSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREW-DRDADKDWPRNRD 1336

Query: 391  RSRSPGSYKQRETRKR 406
            R R     ++RE  KR
Sbjct: 1337 RDRLRERERERERDKR 1352



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 51/246 (20%), Positives = 91/246 (36%), Gaps = 27/246 (10%)

Query: 218 TKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESS 277
           T++    +RK     + ++K+D K     K R+   + ++    ++   S +     +  
Sbjct: 105 TEESSSPVRKESSRGRHREKEDIK---ITKERTPESEEENVEWETNRDDSDNGDINYDYV 161

Query: 278 SESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPR 337
            E     K +KIQR+  K  + +     +   K +     +  +LS S   R+ +K   R
Sbjct: 162 HELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKR 221

Query: 338 FLKHESS---REDSKWSHSDS--------DKKSRTHKHSPEKR------------GSERK 374
               +SS   ++D K S   S         K +++ K  P               G + K
Sbjct: 222 KSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALGKKYK 281

Query: 375 EGSSRSHGREERSRRSRSRSPGSYKQRETR-KRAQRNPGEEQSRRNDSRSHGTDLYRGEK 433
           E        EE++R  + R     +QRE R K    +P  +      SR H +    G  
Sbjct: 282 EKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHSSSSQSGSS 341

Query: 434 MYREHP 439
           + R  P
Sbjct: 342 IQRHSP 347



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 32/154 (20%), Positives = 58/154 (37%), Gaps = 8/154 (5%)

Query: 247  KSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSD 306
            +S S    H+S    S       S       ++S     E+K +  + K+ + S   +SD
Sbjct: 1207 RSPSNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKSRIDQLKRGEPSRSTSSD 1266

Query: 307  SEEKDKSKKRKLHEE-------LSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKS 359
             ++      R+   E        S S  +R++ +E+ R+ +H+  RE  +      +   
Sbjct: 1267 RQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQERDRY-EHDRERERERRDTRQREWDR 1325

Query: 360  RTHKHSPEKRGSERKEGSSRSHGREERSRRSRSR 393
               K  P  R  +R     R   R++R    R R
Sbjct: 1326 DADKDWPRNRDRDRLRERERERERDKRRDLDRER 1359



 Score = 36.6 bits (83), Expect = 0.048
 Identities = 47/230 (20%), Positives = 96/230 (41%), Gaps = 25/230 (10%)

Query: 188  RNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQK 247
            R+L+ +  +++      EED + E  +S    ++Q+L  K+  ++K++++ +  +    +
Sbjct: 874  RSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMR 933

Query: 248  SRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEK-KIQRKKRKKNKCSGHNNSD 306
            ++     H+S              E  E+S  +   NK+K KIQ+K  KK K    ++  
Sbjct: 934  AQDIIGHHQS--------------EDRETSDRAHDENKKKAKIQKKPIKKKK---EDDVG 976

Query: 307  SEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDS---DKKSRTHK 363
             E  +     +  +  S     ++K+ EK    K + S+ DS  S  ++    KK R  +
Sbjct: 977  IERGNIETTSEDGQVFSPKKGQKKKSIEK----KRKKSKGDSDISDEEAAQQSKKKRGPR 1032

Query: 364  HSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGE 413
              P     E  E  +  +G  E S++    +   +   +   R +    E
Sbjct: 1033 TPPITTKEELVEMCNGKNGILEDSQKKEDTAFSDWSDEDVPDRTEVTEAE 1082



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 34/179 (18%), Positives = 67/179 (37%), Gaps = 28/179 (15%)

Query: 246  QKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS----- 300
            Q+SRS    H +              E  ESS   E    ++K+    +++ +       
Sbjct: 871  QESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESS 930

Query: 301  --------GHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSH 352
                    GH+ S+    D+    + H+E      N++KAK + + +K +   +D     
Sbjct: 931  RMRAQDIIGHHQSE----DRETSDRAHDE------NKKKAKIQKKPIK-KKKEDDVGIER 979

Query: 353  SDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNP 411
             + +  S   +    K+G ++K        + ++S+     S     Q+  +KR  R P
Sbjct: 980  GNIETTSEDGQVFSPKKGQKKKS----IEKKRKKSKGDSDISDEEAAQQSKKKRGPRTP 1034


>gi|50962882 G patch domain containing 8 [Homo sapiens]
          Length = 1502

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 75/261 (28%), Positives = 101/261 (38%), Gaps = 80/261 (30%)

Query: 232 EKKKKKKDRKKKKFQKSRSKHK-KHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQ 290
           E+  K    KKKK  K  SKHK KHK+              +T E SS++ES  K KK +
Sbjct: 667 ERSGKSHRHKKKKKHKKSSKHKRKHKA--------------DTEEKSSKAESGEKSKKRK 712

Query: 291 RKKRKKNKCSGHNNSDSEEK-------------------DKSKKRKLHEELSSS------ 325
           ++KRKKNK S   +S+   K                   D S++R L  E  SS      
Sbjct: 713 KRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDSQRRSLPAEEGSSGKKDEG 772

Query: 326 --------HHNREKAKEKP--RFLKHESSREDSKWSH----------SDSDKKSRTHKHS 365
                   H  R+   E P     +   ++  S+ SH          SD     R H+ S
Sbjct: 773 GGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKS 832

Query: 366 P---------EKRGSERKEGSSRSHGREERSRRSRSRSPGS----------YKQRETRKR 406
           P         E  GSE     SRS GR   S RS  RS  S          Y ++ +   
Sbjct: 833 PSQYSEEEEEEDSGSEHSRSRSRS-GRRHSSHRSSRRSYSSSSDASSDQSCYSRQRSYSD 891

Query: 407 AQRNPGEEQSRRNDSRSHGTD 427
              +   ++SRR+  RSH +D
Sbjct: 892 DSYSDYSDRSRRHSKRSHDSD 912



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 62/260 (23%), Positives = 100/260 (38%), Gaps = 41/260 (15%)

Query: 188  RNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQK 247
            R+  ++  SQ     E  +D     L   +  Q  +   + D   +  + + R  ++   
Sbjct: 803  RSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSS 862

Query: 248  SRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDS 307
             RS  + + SSS +SS  S  S                                 + SD 
Sbjct: 863  HRSSRRSYSSSSDASSDQSCYSRQ------------------------------RSYSDD 892

Query: 308  EEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPE 367
               D S + + H + S    + + A  K R  +H+ S  D  +S S S  +SR+  H+ E
Sbjct: 893  SYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCSQSRSRSRSHTRE 952

Query: 368  K-RGSERKEGSSRSHGREERSRRS-------RSRSPGSYKQRETRKRAQRNPGEEQSRRN 419
            + R   R   SS S  R +R  RS       RSRS    + R TR  +QR+   ++S  +
Sbjct: 953  RSRSRGRSRSSSCSRSRSKRRSRSTTAHSWQRSRSYSRDRSRSTRSPSQRSGSRKRSWGH 1012

Query: 420  DS---RSHGTDLYRGEKMYR 436
            +S   R  G   +   K+YR
Sbjct: 1013 ESPEERHSGRRDFIRSKIYR 1032



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 57/207 (27%), Positives = 81/207 (39%), Gaps = 17/207 (8%)

Query: 246  QKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNS 305
            + SRS H+   SS    S  +SS        S  SE   +E       R +++ SG  +S
Sbjct: 803  RSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSR-SGRRHS 861

Query: 306  DSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKH-ESSREDSKWSHS--DSDKKSRTH 362
                  +S           S ++R+++     +  + + SR  SK SH   DSD  S  H
Sbjct: 862  SHRSSRRSYSSSSDASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKH 921

Query: 363  KHSPEKRGSERKEGS---------SRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGE 413
            +    K  S   + S         SRSH RE    RSR RS  S   R   KR  R+   
Sbjct: 922  RSKRHKYSSSDDDYSLSCSQSRSRSRSHTRERS--RSRGRSRSSSCSRSRSKRRSRSTTA 979

Query: 414  EQSRRNDSRSHGTDLYRGEKMYREHPG 440
               +R  SRS+  D  R  +   +  G
Sbjct: 980  HSWQR--SRSYSRDRSRSTRSPSQRSG 1004



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 66/276 (23%), Positives = 114/276 (41%), Gaps = 37/276 (13%)

Query: 152  NASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDPEVE 211
            +ASS       PS +  E   E   S  +  R+  GR  +++  S+   +S  +   +  
Sbjct: 822  DASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSSDASSDQS 881

Query: 212  FLKSLTTKQKQKLLRKLDRLEKKKKKK-DRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSS 270
                  +          DR  +  K+  D     +  S+ + K+HK SSS    S S S 
Sbjct: 882  CYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKHRSKRHKYSSSDDDYSLSCS- 940

Query: 271  TETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNRE 330
                +S S S S+ +E+   R + + + CS         + +SK+R       S   +R 
Sbjct: 941  ----QSRSRSRSHTRERSRSRGRSRSSSCS---------RSRSKRRSRSTTAHSWQRSRS 987

Query: 331  KAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRS 390
             ++++ R  +  S R  S+       K+S  H+ SPE+R S R++          RS+  
Sbjct: 988  YSRDRSRSTRSPSQRSGSR-------KRSWGHE-SPEERHSGRRDFI--------RSKIY 1031

Query: 391  RSRSPGSYKQRETRKRAQRNPG-EEQSRRNDSRSHG 425
            RS+SP  +     R      PG ++  R +DS++ G
Sbjct: 1032 RSQSPHYF-----RSGRGEGPGKKDDGRGDDSKATG 1062



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 63/282 (22%), Positives = 105/282 (37%), Gaps = 64/282 (22%)

Query: 218 TKQKQKLLRKLDRLEKKKKKKDRKKKKF-----------------------QKSRSKHKK 254
           T++K       ++ +K+KK+K +K K                         ++ R++   
Sbjct: 695 TEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGSPAPPRRRRRAQDDS 754

Query: 255 HKSSSSSSSSSSSSSSTETSESSSESESNNKEK------KIQRKK-RKKNKCSGHN---N 304
            + S  +   SS         SSS+     K K        QR+   K++  S H    +
Sbjct: 755 QRRSLPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSCQRRAGTKRSSRSSHRSQPS 814

Query: 305 SDSEEKDKSKKRKLH------------EELSSSHHNREKAKEKPRFLKHESSRE------ 346
           S  E+ D +   +LH            EE S S H+R +++   R   H SSR       
Sbjct: 815 SGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSRSGRRHSSHRSSRRSYSSSS 874

Query: 347 ---------DSKWSHSD---SDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRS 394
                      + S+SD   SD   R+ +HS     S+  + +S  H R +R + S S  
Sbjct: 875 DASSDQSCYSRQRSYSDDSYSDYSDRSRRHSKRSHDSDDSDYASSKH-RSKRHKYSSSDD 933

Query: 395 PGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYR 436
             S    ++R R++ +  E    R  SRS      R ++  R
Sbjct: 934 DYSLSCSQSRSRSRSHTRERSRSRGRSRSSSCSRSRSKRRSR 975



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 96/420 (22%), Positives = 158/420 (37%), Gaps = 58/420 (13%)

Query: 74  APPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIK-CH 132
           A  GA+K   E  E   ET      + G+  E       ++ DQ      + V   + C 
Sbjct: 450 ASQGAEKTVSEVSEQPKETSMTEPSEPGSKAEAKKALGGDVSDQSLESHSQKVSETQMCE 509

Query: 133 KWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTA 192
                N+ +E  L   +G  +   P   +GP      ++++  ++       +L    T 
Sbjct: 510 S----NSSKETSLATPAGKESQEGPKHPTGPFF---PVLSKDESTALQWPSELL--IFTK 560

Query: 193 NDPSQEYVASEGEEDPEVEFLKSLTTKQKQKL----------LRKLDRLEKKKKKKDRKK 242
            +PS  Y  +    D ++   K   TK  +K           L+ LD  E  K K+   +
Sbjct: 561 AEPSISYSCNPLYFDFKLSRNKDARTKGTEKPKDIGSSSKDHLQGLDPGEPNKSKEVGGE 620

Query: 243 KKFQKSRSKHKKHKSSSSSSS------SSSSSSSTETSESSSESESNNKEKKIQRKKRKK 296
           K  + S  +     S S+ S         S  S TE +  S  S+     K  + KK+KK
Sbjct: 621 KIVRSSGGRMDAPASGSACSGLNKQEPGGSHGSETEDTGRSLPSKKERSGKSHRHKKKKK 680

Query: 297 NKCSGHNN----SDSEEK-------DKSKKRKLH---EELSSSHHNREKA-KEKPRFLKH 341
           +K S  +     +D+EEK       +KSKKRK     +  SS+  + E+  K +P     
Sbjct: 681 HKKSSKHKRKHKADTEEKSSKAESGEKSKKRKKRKRKKNKSSAPADSERGPKPEPPGSGS 740

Query: 342 ESSREDSKWSHSDSDKKSRTHKHSPEKRGSERK--EGSSRSHGREERSRRSRSR-SPGSY 398
            +     + +  DS ++S      P + GS  K  EG   S  ++   R+ +    P S 
Sbjct: 741 PAPPRRRRRAQDDSQRRS-----LPAEEGSSGKKDEGGGGSSSQDHGGRKHKGELPPSSC 795

Query: 399 KQRETRKRAQRNPGEEQSRRNDSRSHGTDLYR---------GEKMYREHPGGTHTKVTQR 449
           ++R   KR+ R+    Q    D  S     +R          E+   E  G  H++   R
Sbjct: 796 QRRAGTKRSSRSSHRSQPSSGDEDSDDASSHRLHQKSPSQYSEEEEEEDSGSEHSRSRSR 855


>gi|154146223 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 57/231 (24%), Positives = 110/231 (47%), Gaps = 27/231 (11%)

Query: 205 EEDPEVEFLKSLTTKQKQKLLR-KLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSS 263
           E D +V   K  T  +   +L  K +  EK+K+ + R       S S + +  S+SS+ S
Sbjct: 473 EADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVS 532

Query: 264 SSSSSSSTETSESSSESESNNKEKKIQRK-----KRKKNKCSGHNNSDSEEKDKSKKRKL 318
           SSS SSS+ +S +SS S S  ++K+  R      K ++++   ++     E ++++  K+
Sbjct: 533 SSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARV-KI 591

Query: 319 HEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR------------------ 360
            +   S+ ++ E+ + + R    E  R  S+     +++ SR                  
Sbjct: 592 RDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSG 651

Query: 361 -THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRN 410
            +HKH  E +  ERK+  SRS  + +R ++ + R     K++E +KR +++
Sbjct: 652 NSHKHKGEAKEQERKKERSRSIDK-DRKKKDKEREREQDKRKEKQKREEKD 701



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 85/386 (22%), Positives = 150/386 (38%), Gaps = 42/386 (10%)

Query: 29  EQKISYDKKKQEELMQ--QYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKE 86
           EQ++ +DK+ +EE  Q  +  KE   + ++        +N L+ + EA         EK+
Sbjct: 432 EQQLLHDKQMEEEKQQTERVTKEMNEFIHK-------EQNSLSLL-EAREADGDVVNEKK 483

Query: 87  ETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLF 146
            T  ET    E +K   +EK  +          G    N R           T       
Sbjct: 484 RTPNETTSVLEPKK-EHKEKEKQGRSRSGSSSSGSSSSNSR-----------TSSTSSTV 531

Query: 147 GLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALK-RNVLGRNLTANDPSQEYVASEGE 205
             S  ++SS  +  S  S  P       R+    +K R    R+ +     +   A    
Sbjct: 532 SSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKI 591

Query: 206 EDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKK----HKSSSSS 261
            D       S+  ++++      +R   + + +DR+  +  +SRS+ ++     + + S 
Sbjct: 592 RDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSG 651

Query: 262 SSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKD---KSKKRKL 318
           +S      + E       S S +K++K + K+R++ +         EEKD    S+  +L
Sbjct: 652 NSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRL 711

Query: 319 HEELSSSHHNREKAKEKPRFLKHESSREDSKWS-------HSDSDKKSRTHKHSP----E 367
             +  S            + ++H+S R+DSK S       HS SD   R+   SP    E
Sbjct: 712 KRKRESERTFSRSGSISVKIIRHDS-RQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKE 770

Query: 368 KRGSERKEGSSRSHGREERSRRSRSR 393
           K+  + K   SRS  + +RS +  SR
Sbjct: 771 KKAKKPKHSRSRSVEKSQRSGKKASR 796



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 61/223 (27%), Positives = 101/223 (45%), Gaps = 41/223 (18%)

Query: 236 KKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRK 295
           KK+ ++K+K  +SRS      SSSS+S +SS+SS+  +S  SS S S+    +    KRK
Sbjct: 496 KKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRK 555

Query: 296 KNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDS 355
           K      + +    + +S+      ++ S   NR + K +           D + S+ +S
Sbjct: 556 KRHSRSRSPTIKARRSRSRSYSRRIKIES---NRARVKIR-----------DRRRSNRNS 601

Query: 356 DKKSRTHKHSPEKRGSERKEGSSRSHGREERSRR-SRSRS-------------------- 394
            ++ R    SP +   ER+   SRS  R+ R+ R SRSRS                    
Sbjct: 602 IERERRRNRSPSR---ERRR--SRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKH 656

Query: 395 PGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
            G  K++E +K   R+  +++ +++  R    D  R EK  RE
Sbjct: 657 KGEAKEQERKKERSRSIDKDRKKKDKEREREQD-KRKEKQKRE 698



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 44/200 (22%), Positives = 86/200 (43%), Gaps = 18/200 (9%)

Query: 232 EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQR 291
           E+++ +   ++++  +SRS+ ++   +S S S        +    S  S  +  E K Q 
Sbjct: 605 ERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQE 664

Query: 292 KKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWS 351
           +K+++          S   DK +K+K  E        +EK K + +  K  S  +  K  
Sbjct: 665 RKKER----------SRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRK 714

Query: 352 HSDSDKKSRTH-------KHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETR 404
                  SR+        +H   +   +     S+ H   + S RS S SPGS K+++ +
Sbjct: 715 RESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAK 774

Query: 405 K-RAQRNPGEEQSRRNDSRS 423
           K +  R+   E+S+R+  ++
Sbjct: 775 KPKHSRSRSVEKSQRSGKKA 794



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 87/434 (20%), Positives = 169/434 (38%), Gaps = 73/434 (16%)

Query: 17  ASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPP 76
           A K      W+ E     +++KQ++L ++ +++Q S  +                     
Sbjct: 226 AVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLS--------------------- 264

Query: 77  GAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGH 136
             KKE K  E+ EG    +   +     ++  +D  N+     G   R+   +   +   
Sbjct: 265 --KKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSD 322

Query: 137 ---VNTDRECPLFGLSGINASSVPTDGSGPSMH-------------PSELIAEMRNSGFA 180
                 ++E  +  L+ +  + +  D +   ++             P++ +A+  +S  A
Sbjct: 323 PEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQ--SSALA 380

Query: 181 LKRNVLGRNLTANDPSQEYVASEGEE--DPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKK 238
               + G     +  S++  +  G E  D + E L+    ++++   RK    EK+++  
Sbjct: 381 SLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRK----EKEQQLL 436

Query: 239 DRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNK 298
             K+ + +K +++    + +       +S S  E  E+  +         +  KKR  N+
Sbjct: 437 HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDV--------VNEKKRTPNE 488

Query: 299 CSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKK 358
            +       E K+K K+ +     SSS  +   ++         +S   S  S+S S   
Sbjct: 489 TTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTS------STSSTVSSSSYSSSSGS 542

Query: 359 SRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRET---------RKRAQR 409
           SRT   S   +   RK+  SRS     ++RRSRSRS     + E+         R+R+ R
Sbjct: 543 SRTSSRSSSPK---RKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNR 599

Query: 410 NPGEEQSRRNDSRS 423
           N  E + RRN S S
Sbjct: 600 NSIERERRRNRSPS 613



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 44/166 (26%), Positives = 77/166 (46%), Gaps = 10/166 (6%)

Query: 189 NLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQ-K 247
           NL+ N  S ++     E++ + E  +S+   +K+K   +    +K+K+K+ R++K F+  
Sbjct: 648 NLSGN--SHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFS 705

Query: 248 SRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDS 307
           S+    K K  S  + S S S S +     S  +S     K   KK   +  SG ++S+S
Sbjct: 706 SQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTK-DSKKHSGSDSSGRSSSES 764

Query: 308 EEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHS 353
               K KK K         H+R ++ EK +    ++SR+    S S
Sbjct: 765 PGSSKEKKAK------KPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 42/151 (27%), Positives = 66/151 (43%), Gaps = 9/151 (5%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSS 278
           ++K++  R +D+ ++KKK K+R++++  K + K K+ +     SS          SE + 
Sbjct: 664 ERKKERSRSIDK-DRKKKDKEREREQ-DKRKEKQKREEKDFKFSSQDDRLKRKRESERTF 721

Query: 279 ESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRF 338
               +   K I+   R+ +K S   +S       S  R   E   SS   +EK  +KP  
Sbjct: 722 SRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSS---KEKKAKKP-- 776

Query: 339 LKHESSREDSKWSHSDSDKKSRTHKHSPEKR 369
            KH  SR   K S     K SR HK     R
Sbjct: 777 -KHSRSRSVEK-SQRSGKKASRKHKSKSRSR 805



 Score = 32.7 bits (73), Expect = 0.69
 Identities = 23/116 (19%), Positives = 52/116 (44%), Gaps = 2/116 (1%)

Query: 205 EEDPEVEFLKSLTTKQK-QKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSS 263
           +E P+++ +K  T     ++ L K++R ++KK +K+R +++  +   K KK    +    
Sbjct: 219 QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGD 278

Query: 264 SSSSSSSTETSESSSESESNNKEKKIQRK-KRKKNKCSGHNNSDSEEKDKSKKRKL 318
                  ++      E ++ N E     K  R  +      +SD E  ++ K+ ++
Sbjct: 279 GPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQM 334


>gi|154146193 splicing factor, arginine/serine-rich 130 [Homo
           sapiens]
          Length = 805

 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 57/231 (24%), Positives = 110/231 (47%), Gaps = 27/231 (11%)

Query: 205 EEDPEVEFLKSLTTKQKQKLLR-KLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSS 263
           E D +V   K  T  +   +L  K +  EK+K+ + R       S S + +  S+SS+ S
Sbjct: 473 EADGDVVNEKKRTPNETTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVS 532

Query: 264 SSSSSSSTETSESSSESESNNKEKKIQRK-----KRKKNKCSGHNNSDSEEKDKSKKRKL 318
           SSS SSS+ +S +SS S S  ++K+  R      K ++++   ++     E ++++  K+
Sbjct: 533 SSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARV-KI 591

Query: 319 HEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR------------------ 360
            +   S+ ++ E+ + + R    E  R  S+     +++ SR                  
Sbjct: 592 RDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSG 651

Query: 361 -THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRN 410
            +HKH  E +  ERK+  SRS  + +R ++ + R     K++E +KR +++
Sbjct: 652 NSHKHKGEAKEQERKKERSRSIDK-DRKKKDKEREREQDKRKEKQKREEKD 701



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 85/386 (22%), Positives = 150/386 (38%), Gaps = 42/386 (10%)

Query: 29  EQKISYDKKKQEELMQ--QYLKEQESYDNRLLMGDERVKNGLNFMYEAPPGAKKENKEKE 86
           EQ++ +DK+ +EE  Q  +  KE   + ++        +N L+ + EA         EK+
Sbjct: 432 EQQLLHDKQMEEEKQQTERVTKEMNEFIHK-------EQNSLSLL-EAREADGDVVNEKK 483

Query: 87  ETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGHVNTDRECPLF 146
            T  ET    E +K   +EK  +          G    N R           T       
Sbjct: 484 RTPNETTSVLEPKK-EHKEKEKQGRSRSGSSSSGSSSSNSR-----------TSSTSSTV 531

Query: 147 GLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALK-RNVLGRNLTANDPSQEYVASEGE 205
             S  ++SS  +  S  S  P       R+    +K R    R+ +     +   A    
Sbjct: 532 SSSSYSSSSGSSRTSSRSSSPKRKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKI 591

Query: 206 EDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKK----HKSSSSS 261
            D       S+  ++++      +R   + + +DR+  +  +SRS+ ++     + + S 
Sbjct: 592 RDRRRSNRNSIERERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSG 651

Query: 262 SSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKD---KSKKRKL 318
           +S      + E       S S +K++K + K+R++ +         EEKD    S+  +L
Sbjct: 652 NSHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRL 711

Query: 319 HEELSSSHHNREKAKEKPRFLKHESSREDSKWS-------HSDSDKKSRTHKHSP----E 367
             +  S            + ++H+S R+DSK S       HS SD   R+   SP    E
Sbjct: 712 KRKRESERTFSRSGSISVKIIRHDS-RQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKE 770

Query: 368 KRGSERKEGSSRSHGREERSRRSRSR 393
           K+  + K   SRS  + +RS +  SR
Sbjct: 771 KKAKKPKHSRSRSVEKSQRSGKKASR 796



 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 61/223 (27%), Positives = 101/223 (45%), Gaps = 41/223 (18%)

Query: 236 KKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRK 295
           KK+ ++K+K  +SRS      SSSS+S +SS+SS+  +S  SS S S+    +    KRK
Sbjct: 496 KKEHKEKEKQGRSRSGSSSSGSSSSNSRTSSTSSTVSSSSYSSSSGSSRTSSRSSSPKRK 555

Query: 296 KNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDS 355
           K      + +    + +S+      ++ S   NR + K +           D + S+ +S
Sbjct: 556 KRHSRSRSPTIKARRSRSRSYSRRIKIES---NRARVKIR-----------DRRRSNRNS 601

Query: 356 DKKSRTHKHSPEKRGSERKEGSSRSHGREERSRR-SRSRS-------------------- 394
            ++ R    SP +   ER+   SRS  R+ R+ R SRSRS                    
Sbjct: 602 IERERRRNRSPSR---ERRR--SRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKH 656

Query: 395 PGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
            G  K++E +K   R+  +++ +++  R    D  R EK  RE
Sbjct: 657 KGEAKEQERKKERSRSIDKDRKKKDKEREREQD-KRKEKQKRE 698



 Score = 60.8 bits (146), Expect = 2e-09
 Identities = 44/200 (22%), Positives = 86/200 (43%), Gaps = 18/200 (9%)

Query: 232 EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQR 291
           E+++ +   ++++  +SRS+ ++   +S S S        +    S  S  +  E K Q 
Sbjct: 605 ERRRNRSPSRERRRSRSRSRDRRTNRASRSRSRDRRKIDDQRGNLSGNSHKHKGEAKEQE 664

Query: 292 KKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWS 351
           +K+++          S   DK +K+K  E        +EK K + +  K  S  +  K  
Sbjct: 665 RKKER----------SRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFSSQDDRLKRK 714

Query: 352 HSDSDKKSRTH-------KHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETR 404
                  SR+        +H   +   +     S+ H   + S RS S SPGS K+++ +
Sbjct: 715 RESERTFSRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSSKEKKAK 774

Query: 405 K-RAQRNPGEEQSRRNDSRS 423
           K +  R+   E+S+R+  ++
Sbjct: 775 KPKHSRSRSVEKSQRSGKKA 794



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 87/434 (20%), Positives = 169/434 (38%), Gaps = 73/434 (16%)

Query: 17  ASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLNFMYEAPP 76
           A K      W+ E     +++KQ++L ++ +++Q S  +                     
Sbjct: 226 AVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLS--------------------- 264

Query: 77  GAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVRNVRCIKCHKWGH 136
             KKE K  E+ EG    +   +     ++  +D  N+     G   R+   +   +   
Sbjct: 265 --KKEKKATEDAEGGDGPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSD 322

Query: 137 ---VNTDRECPLFGLSGINASSVPTDGSGPSMH-------------PSELIAEMRNSGFA 180
                 ++E  +  L+ +  + +  D +   ++             P++ +A+  +S  A
Sbjct: 323 PEMTEEEKEYQMMLLTKMLLTEILLDVTDEEIYYVAKDAHRKATKAPAKQLAQ--SSALA 380

Query: 181 LKRNVLGRNLTANDPSQEYVASEGEE--DPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKK 238
               + G     +  S++  +  G E  D + E L+    ++++   RK    EK+++  
Sbjct: 381 SLTGLGGLGGYGSGDSEDERSDRGSESSDTDDEELRHRIRQKQEAFWRK----EKEQQLL 436

Query: 239 DRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNK 298
             K+ + +K +++    + +       +S S  E  E+  +         +  KKR  N+
Sbjct: 437 HDKQMEEEKQQTERVTKEMNEFIHKEQNSLSLLEAREADGDV--------VNEKKRTPNE 488

Query: 299 CSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKK 358
            +       E K+K K+ +     SSS  +   ++         +S   S  S+S S   
Sbjct: 489 TTSVLEPKKEHKEKEKQGRSRSGSSSSGSSSSNSRTS------STSSTVSSSSYSSSSGS 542

Query: 359 SRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRET---------RKRAQR 409
           SRT   S   +   RK+  SRS     ++RRSRSRS     + E+         R+R+ R
Sbjct: 543 SRTSSRSSSPK---RKKRHSRSRSPTIKARRSRSRSYSRRIKIESNRARVKIRDRRRSNR 599

Query: 410 NPGEEQSRRNDSRS 423
           N  E + RRN S S
Sbjct: 600 NSIERERRRNRSPS 613



 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 44/166 (26%), Positives = 77/166 (46%), Gaps = 10/166 (6%)

Query: 189 NLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQ-K 247
           NL+ N  S ++     E++ + E  +S+   +K+K   +    +K+K+K+ R++K F+  
Sbjct: 648 NLSGN--SHKHKGEAKEQERKKERSRSIDKDRKKKDKEREREQDKRKEKQKREEKDFKFS 705

Query: 248 SRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDS 307
           S+    K K  S  + S S S S +     S  +S     K   KK   +  SG ++S+S
Sbjct: 706 SQDDRLKRKRESERTFSRSGSISVKIIRHDSRQDSKKSTTK-DSKKHSGSDSSGRSSSES 764

Query: 308 EEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHS 353
               K KK K         H+R ++ EK +    ++SR+    S S
Sbjct: 765 PGSSKEKKAK------KPKHSRSRSVEKSQRSGKKASRKHKSKSRS 804



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 42/151 (27%), Positives = 66/151 (43%), Gaps = 9/151 (5%)

Query: 219 KQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSS 278
           ++K++  R +D+ ++KKK K+R++++  K + K K+ +     SS          SE + 
Sbjct: 664 ERKKERSRSIDK-DRKKKDKEREREQ-DKRKEKQKREEKDFKFSSQDDRLKRKRESERTF 721

Query: 279 ESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRF 338
               +   K I+   R+ +K S   +S       S  R   E   SS   +EK  +KP  
Sbjct: 722 SRSGSISVKIIRHDSRQDSKKSTTKDSKKHSGSDSSGRSSSESPGSS---KEKKAKKP-- 776

Query: 339 LKHESSREDSKWSHSDSDKKSRTHKHSPEKR 369
            KH  SR   K S     K SR HK     R
Sbjct: 777 -KHSRSRSVEK-SQRSGKKASRKHKSKSRSR 805



 Score = 32.7 bits (73), Expect = 0.69
 Identities = 23/116 (19%), Positives = 52/116 (44%), Gaps = 2/116 (1%)

Query: 205 EEDPEVEFLKSLTTKQK-QKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSS 263
           +E P+++ +K  T     ++ L K++R ++KK +K+R +++  +   K KK    +    
Sbjct: 219 QEPPQIDAVKRRTLPAWIREGLEKMEREKQKKLEKERMEQQRSQLSKKEKKATEDAEGGD 278

Query: 264 SSSSSSSTETSESSSESESNNKEKKIQRK-KRKKNKCSGHNNSDSEEKDKSKKRKL 318
                  ++      E ++ N E     K  R  +      +SD E  ++ K+ ++
Sbjct: 279 GPRLPQRSKFDSDEEEEDTENVEAASSGKVTRSPSPVPQEEHSDPEMTEEEKEYQM 334


>gi|6631100 natural killer-tumor recognition sequence [Homo sapiens]
          Length = 1462

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 71/291 (24%), Positives = 117/291 (40%), Gaps = 36/291 (12%)

Query: 170 LIAEMRNSGFALKRNVLGRN-LTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKL 228
           ++++ + S     R + GR  +  + P +    SE ++D   E       K++ + LR  
Sbjct: 318 IVSDQKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHW--KEEMQRLRAY 375

Query: 229 DRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKK 288
                +K  K  K      SR   +     S S S +   S   T+  S   +   KEKK
Sbjct: 376 RPPSGEKWSKGDKLSDPCSSRWDERSLSQRSRSWSYNGYYSDLSTARHSGHHKKRRKEKK 435

Query: 289 IQRKKR--KKNKCSGHNNSDSE--------EKDKSKKRKLHEELSSSHHNREKAKEKPRF 338
           ++ KK+  K+  C  H  +           E  KS  R++      S  +RE++      
Sbjct: 436 VKHKKKGKKQKHCRRHKQTKKRRILIPSDIESSKSSTRRM-----KSSCDRERSSRSSSL 490

Query: 339 LKHESSREDSKWSHSDSDKKS----------RTHKHSPE-KRGSERKEGSSRSHGREERS 387
             H SS+ D  WS SD D +S          R+  HS    RGS R   +S+S       
Sbjct: 491 SSHHSSKRD--WSKSDKDVQSSLTHSSRDSYRSKSHSQSYSRGSSRSRTASKSSSHSRSR 548

Query: 388 RRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYREH 438
            +SRS S   +     RKRA ++P +  S+ ++++   T+  R      E+
Sbjct: 549 SKSRSSSKSGH-----RKRASKSPRKTASQLSENKPVKTEPLRATMAQNEN 594



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 63/252 (25%), Positives = 96/252 (38%), Gaps = 63/252 (25%)

Query: 235 KKKKDRKKKKFQKSRSKHKKHKSSSSSS---------------------------SSSSS 267
           ++ K R +   +K+   HKKH SSS  +                           SS S 
Sbjct: 753 RRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSE 812

Query: 268 SSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSE-EKDKSKKRKLHEELSSSH 326
            SS + ++S+ E E   K+ +++R   K+ K  G   S SE E   SKKR L E LS   
Sbjct: 813 QSSVQATQSAQEKE---KQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSDHL 869

Query: 327 HNREKAKEKPRFLKHESSREDSKW-SHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREE 385
            N  K K K        +   SKW S S+S++    +  +     S+++EG + S    E
Sbjct: 870 RNGSKPKRK--------NYAGSKWDSESNSERDVTKNSKNDSHPSSDKEEGEATSDSESE 921

Query: 386 RSRRSRSRSP--------------GSYKQRETRKRAQRNPGEEQSRRND-----SRSHGT 426
            S       P              G++K  + R     + G   +  N+        HG+
Sbjct: 922 VSEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGS 981

Query: 427 DLYRGEKMYREH 438
                E + REH
Sbjct: 982 K----ENLKREH 989



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 39/173 (22%), Positives = 76/173 (43%), Gaps = 3/173 (1%)

Query: 236 KKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRK 295
           K  DR  +   +SRS+  + +S S S + S S +S+ +   S  S S+++ K     +  
Sbjct: 680 KYSDRSSESSPRSRSRSSRSRSYSRSYTRSRSLASSHSRSRSPSSRSHSRNKYSDHSQCS 739

Query: 296 KNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDS 355
           ++      +SD   + K + R   ++ S SH     + EK    K+   R+ S      S
Sbjct: 740 RSSSYTSISSDDGRRAKRRLRSSGKKNSVSHKKHSSSSEKTLHSKYVKGRDRSSCVRKYS 799

Query: 356 DKKSRTHKHSPEKRGSERKEGSSR---SHGREERSRRSRSRSPGSYKQRETRK 405
           + +S     S  ++ S +   S++     G+ ER+   + ++ G  K +  R+
Sbjct: 800 ESRSSLDYSSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERE 852



 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 59/272 (21%), Positives = 116/272 (42%), Gaps = 31/272 (11%)

Query: 202  SEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSS 261
            S   E   V+  +S   K+KQ  + +    ++K + +++ K + +   SK +  K + S 
Sbjct: 808  SSDSEQSSVQATQSAQEKEKQGQMERTHNKQEKNRGEEKSKSERECPHSKKRTLKENLSD 867

Query: 262  SSSSSSSSSTETSESSS-ESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKD-----KSKK 315
               + S    +    S  +SESN+     +R   K +K   H +SD EE +     +S+ 
Sbjct: 868  HLRNGSKPKRKNYAGSKWDSESNS-----ERDVTKNSKNDSHPSSDKEEGEATSDSESEV 922

Query: 316  RKLHEEL-----SSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDK---KSRTHKHSPE 367
             ++H ++     SS++ +        +  K  +S  DS+ S S+S+    K + HKH  +
Sbjct: 923  SEIHIKVKPTTKSSTNTSLPDDNGAWKSSKQRTSTSDSEGSCSNSENNRGKPQKHKHGSK 982

Query: 368  --------KRGSERKEG-SSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRR 418
                    K+  E+ +G   + H   +R +    + P  + + E  +   +   +E   +
Sbjct: 983  ENLKREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPLEFGEEEEEEIDDKQVTQESKEK 1042

Query: 419  NDSRSHGT---DLYRGEKMYREHPGGTHTKVT 447
              S ++ T   ++ + EK   E   G H  VT
Sbjct: 1043 KVSENNETIKDNILKTEKSSEEDLSGKHDTVT 1074



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 67/249 (26%), Positives = 101/249 (40%), Gaps = 26/249 (10%)

Query: 200 VASEGEEDPEVEFLKSLTTKQKQKLLRKLD-RLEKKKKKKDRKKKKFQKSRSKHKKHKSS 258
           V S  E   ++E LK+    +    +R +D  +   K  KD  +KK +K         SS
Sbjct: 143 VISGFEVIEQIENLKTDAASRPYADVRVIDCGVLATKSIKDVFEKKRKKPTHSEGSDSSS 202

Query: 259 SSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS--------------GHN- 303
           +SSSSS SSS S E     S    + +  K++R K+++ + S              GH+ 
Sbjct: 203 NSSSSSESSSES-ELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPKGHSE 261

Query: 304 NSDSEEK---DKSKKRK----LHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSD 356
            SD+ EK   D S KR+      EE+     NR   +     +  E   +    +   SD
Sbjct: 262 RSDTNEKRSVDSSAKREKPVVRPEEIPPVPENRFLLRRDMPVVTAEPEPKIPDVAPIVSD 321

Query: 357 KKSRTHK--HSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEE 414
           +K    K     + RG+ R     RS    E      S +P  +K+   R RA R P  E
Sbjct: 322 QKPSVSKSGRKIKGRGTIRYHTPPRSRSCSESDDDDSSETPPHWKEEMQRLRAYRPPSGE 381

Query: 415 QSRRNDSRS 423
           +  + D  S
Sbjct: 382 KWSKGDKLS 390



 Score = 52.8 bits (125), Expect = 6e-07
 Identities = 55/220 (25%), Positives = 90/220 (40%), Gaps = 24/220 (10%)

Query: 209  EVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSS--- 265
            EV+ L ++   + Q L     R+E K K K R    F + R   + ++   +  SSS   
Sbjct: 1247 EVKVLTTVPEMKPQGL-----RIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQ 1301

Query: 266  -------SSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKL 318
                   S S S   S S SE++S ++ + +     +    S  ++  S    +S+ R  
Sbjct: 1302 TPSRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRSRSRSSTSSYRSRSYSRSRSRGW 1361

Query: 319  HEELSSSHHNREKAKEKPRFLKHE-SSREDSKWSHSDSDKKSRTHKHS---PEKRGSERK 374
            +    S    R ++     +  H  SSR  S+ S  D   +SR++ +       R   R 
Sbjct: 1362 Y----SRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHSRSRSYTYDSYYSRSRSRSRS 1417

Query: 375  EGSSRSHGREERSRRSRS-RSPGSYKQRETRKRAQRNPGE 413
            + S   H     +RRSRS RS GS  + +      R+P E
Sbjct: 1418 QRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSE 1457



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 46/209 (22%), Positives = 86/209 (41%), Gaps = 13/209 (6%)

Query: 243 KKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGH 302
           K+   S S HK+ K+S S  S+ S     + S+ SSES   ++ +  + +   ++     
Sbjct: 656 KETGSSSSYHKREKNSESDQSTYS-----KYSDRSSESSPRSRSRSSRSRSYSRSYTRSR 710

Query: 303 NNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTH 362
           + + S  + +S   + H     S H++         +  +  R   +   S   K S +H
Sbjct: 711 SLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSISSDDGRRAKRRLRSSGKKNSVSH 770

Query: 363 KHSPEKRGSERKEGSSRSHGREERS---RRSRSRSPGSYK--QRETRKRAQRNPGEEQSR 417
           K       SE+   S    GR+  S   + S SRS   Y     ++  +A ++  E++ +
Sbjct: 771 K--KHSSSSEKTLHSKYVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEKEKQ 828

Query: 418 RNDSRSHG-TDLYRGEKMYREHPGGTHTK 445
               R+H   +  RGE+  +      H+K
Sbjct: 829 GQMERTHNKQEKNRGEEKSKSERECPHSK 857



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 92/439 (20%), Positives = 172/439 (39%), Gaps = 86/439 (19%)

Query: 11   KKDF-HPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMGDERVKNGLN 69
            KKD  H A K   K+ +  +  + + ++++EE+  + +  QES + ++   +E +K+ + 
Sbjct: 1000 KKDKKHKAPKR--KQAFHWQPPLEFGEEEEEEIDDKQVT-QESKEKKVSENNETIKDNI- 1055

Query: 70   FMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFGIQVR-NVRC 128
                     K E   +E+  G+ +        +  +++ KDD  +   P  +    NV C
Sbjct: 1056 --------LKTEKSSEEDLSGKHDTV---TVSSDLDQFTKDDSKLSISPTALNTEENVAC 1104

Query: 129  IKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGR 188
            ++     ++    E    G+  +    + TD +       E+    R+S   ++      
Sbjct: 1105 LQ-----NIQHVEESVPNGVEDV----LQTDDN------MEICTPDRSSPAKVEETSPLG 1149

Query: 189  NLTANDPSQEYVASE--GEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQ 246
            N   + P    V  +    E P+ E +K  ++  + K+L ++                  
Sbjct: 1150 NARLDTPDINIVLKQDMATEHPQAEVVKQESSMSESKVLGEVG----------------- 1192

Query: 247  KSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSD 306
                     K  SSS+S +S+  ST   E + +S+ N  +KK +  +   N  + +  + 
Sbjct: 1193 ---------KQDSSSASLASAGESTGKKEVAEKSQINLIDKKWKPLQGVGNLAAPNAATS 1243

Query: 307  SEEKDK-------SKKRKLHEELSSSHHNR--------EKAKEKPRFLKHESSREDSKWS 351
            S  + K        K + L  E+ S +  R         K     R  +++ S  D +  
Sbjct: 1244 SAVEVKVLTTVPEMKPQGLRIEIKSKNKVRPGSLFDEVRKTARLNRRPRNQESSSDEQTP 1303

Query: 352  HSDSDKKSRTHKHSPEK---RGSERKEGSSRSHGREERSRRSRSRSPGSYKQRE---TRK 405
              D D +SR+   S  K   +   R    S SH R     RSRS S  SY+ R    +R 
Sbjct: 1304 SRDDDSQSRSPSRSRSKSETKSRHRTRSVSYSHSRS----RSRS-STSSYRSRSYSRSRS 1358

Query: 406  RAQRNPGEEQSRRNDSRSH 424
            R   + G  +SR +  RS+
Sbjct: 1359 RGWYSRGRTRSRSSSYRSY 1377



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 54/260 (20%), Positives = 95/260 (36%), Gaps = 48/260 (18%)

Query: 149 SGINASSVPTDGSGPSMHPSELIAEMRNSGFALKRNVLGRNLTANDPSQEYVASEGEEDP 208
           S  + +++   GS  S H  E  +E   S ++                 +Y     E  P
Sbjct: 648 STYSLANIKETGSSSSYHKREKNSESDQSTYS-----------------KYSDRSSESSP 690

Query: 209 EVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSS 268
                 S +    +   R   R       + R       SR+K+  H   S SSS +S S
Sbjct: 691 RSRSRSSRSRSYSRSYTRS--RSLASSHSRSRSPSSRSHSRNKYSDHSQCSRSSSYTSIS 748

Query: 269 SSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHN 328
                      S+   + K+  R   KKN  S   +S S EK             + H  
Sbjct: 749 -----------SDDGRRAKRRLRSSGKKNSVSHKKHSSSSEK-------------TLHSK 784

Query: 329 REKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSR 388
             K +++   ++  S    S    SDS++ S     S +++  E++    R+H ++E++R
Sbjct: 785 YVKGRDRSSCVRKYSESRSSLDYSSDSEQSSVQATQSAQEK--EKQGQMERTHNKQEKNR 842

Query: 389 ---RSRSRSPGSYKQRETRK 405
              +S+S     + ++ T K
Sbjct: 843 GEEKSKSERECPHSKKRTLK 862



 Score = 35.0 bits (79), Expect = 0.14
 Identities = 23/86 (26%), Positives = 36/86 (41%), Gaps = 2/86 (2%)

Query: 353 SDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNP- 411
           SDS   S +   S  +   E +    R H R  + +RS+ R   +    E R +   NP 
Sbjct: 198 SDSSSNSSSSSESSSESELEHERSRRRKHKRRPKVKRSKKRRKEASSSEEPRNKHAMNPK 257

Query: 412 -GEEQSRRNDSRSHGTDLYRGEKMYR 436
              E+S  N+ RS  +   R + + R
Sbjct: 258 GHSERSDTNEKRSVDSSAKREKPVVR 283



 Score = 32.7 bits (73), Expect = 0.69
 Identities = 27/125 (21%), Positives = 50/125 (40%), Gaps = 3/125 (2%)

Query: 230  RLEKKKKKKDRKKKKFQKSRSK--HKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEK 287
            R   +      + + + +SRS+  + + ++ S SSS  S  S   +S S S S S +   
Sbjct: 1338 RSRSRSSTSSYRSRSYSRSRSRGWYSRGRTRSRSSSYRSYKSHRTSSRSRSRSSSYDPHS 1397

Query: 288  KIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPR-FLKHESSRE 346
            + +            + S S+  D   + + +   S S  +     E  R +  H S  E
Sbjct: 1398 RSRSYTYDSYYSRSRSRSRSQRSDSYHRGRSYNRRSRSCRSYGSDSESDRSYSHHRSPSE 1457

Query: 347  DSKWS 351
             S++S
Sbjct: 1458 SSRYS 1462



 Score = 31.2 bits (69), Expect = 2.0
 Identities = 26/108 (24%), Positives = 48/108 (44%), Gaps = 6/108 (5%)

Query: 236  KKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRK 295
            K++  KK K +    K KKHK+     +           E   E E    +K++ ++ ++
Sbjct: 986  KREHTKKVKEKLKGKKDKKHKAPKRKQAFHWQPPL----EFGEEEEEEIDDKQVTQESKE 1041

Query: 296  KNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHES 343
            K K S +N +  +   K++K    E+LS  H     + +  +F K +S
Sbjct: 1042 K-KVSENNETIKDNILKTEKSS-EEDLSGKHDTVTVSSDLDQFTKDDS 1087


>gi|14149807 coiled-coil domain containing 55 isoform 1 [Homo
           sapiens]
          Length = 558

 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 88/444 (19%), Positives = 176/444 (39%), Gaps = 27/444 (6%)

Query: 1   MGKSFANFMCKKDFHPASKSNIKKVWMAEQKISYDKKKQEELMQQYLKEQESYDNRLLMG 60
           + +S      KK     +K  I+K  +AE    Y+     + MQ   K++E  + +LL+G
Sbjct: 41  VSESLQREAAKKQAMKQTKLEIQKA-LAEDATVYEYDSIYDEMQ---KKKEENNPKLLLG 96

Query: 61  DERVKNGLNFMYEAPPGAKKENKEKEETEGETEYKFEWQKGAPREKYAKDDMNIRDQPFG 120
            +R    ++ + +A    KKE +++ E + + E + E  +   +E +       + Q   
Sbjct: 97  KDRKPKYIHNLLKAVEIRKKEQEKRMEKKIQREREMEKGEFDDKEAFVTSAYKKKLQERA 156

Query: 121 IQV-RNVRCIKCHKWGHVNTDRECPLFGLSGINASSVPTDGSGPSMHPSEL-IAEMRNSG 178
            +  R  R         V   ++   F    +N +    +    S   +   I E ++ G
Sbjct: 157 EEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREARSGIKEEKSRG 216

Query: 179 FALKRNVLGRNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKK 238
           F+    V  +N    +        + EE+P+ +       K         D +E+ +   
Sbjct: 217 FS--NEVSSKNRIPQEKCILQTDVKVEENPDAD--SDFDAKSSAD-----DEIEETRVNC 267

Query: 239 DRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNK 298
            R++K  +   +  K H+S + S S S     +    +     S   EK+  + ++K+++
Sbjct: 268 -RREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGSRTSRGHEKREDQHQQKQSR 326

Query: 299 CSGHNNSDSE-EKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDK 357
              ++ +D +  K++   R        SH  R + ++KPR  + +  R D  W      +
Sbjct: 327 DQENHYTDRDYRKERDSHRHREASHRDSHWKRHEQEDKPR-ARDQRERSDRVWKREKDRE 385

Query: 358 K------SRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNP 411
           K       R  + + + R SE+ E   +S  +EE  +  + R   + K R+   R +R  
Sbjct: 386 KYSQREQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVRKERYENNDKYRD---REKREV 442

Query: 412 GEEQSRRNDSRSHGTDLYRGEKMY 435
           G + S RN  R   +   R +  +
Sbjct: 443 GVQSSERNQDRKESSPNSRAKDKF 466



 Score = 48.9 bits (115), Expect = 9e-06
 Identities = 61/269 (22%), Positives = 105/269 (39%), Gaps = 35/269 (13%)

Query: 205 EEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSS 264
           E +P++   K    K    LL+ ++   +KK+++ R +KK Q+ R   K       +  +
Sbjct: 88  ENNPKLLLGKDRKPKYIHNLLKAVEI--RKKEQEKRMEKKIQREREMEKGEFDDKEAFVT 145

Query: 265 SSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGH-----NNSDSEEK-----DKSK 314
           S+     +      E E      +      K+   SG      N +  EE+      +  
Sbjct: 146 SAYKKKLQERAEEEEREKRAAALEACLDVTKQKDLSGFYRHLLNQAVGEEEVPKCSFREA 205

Query: 315 KRKLHEELSSSHHNREKAK----EKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRG 370
           +  + EE S    N   +K    ++   L+ +   E++  + SD D KS       E R 
Sbjct: 206 RSGIKEEKSRGFSNEVSSKNRIPQEKCILQTDVKVEENPDADSDFDAKSSADDEIEETRV 265

Query: 371 SERKE------------GSSRSHGR---EERSRRSRSRSPGSYKQRETRKRAQRNPGEEQ 415
           + R+E              S++H R   EER   +R  + GS   R +R   +R    +Q
Sbjct: 266 NCRREKVIETPENDFKHHRSQNHSRSPSEERGHSTRHHTKGS---RTSRGHEKREDQHQQ 322

Query: 416 SRRNDSRSHGTDL-YRGEKMYREHPGGTH 443
            +  D  +H TD  YR E+    H   +H
Sbjct: 323 KQSRDQENHYTDRDYRKERDSHRHREASH 351



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 37/213 (17%), Positives = 91/213 (42%), Gaps = 21/213 (9%)

Query: 227 KLDRLEKKKKKKDRKK----KKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESES 282
           K +   ++K+ +D++     + ++K R  H +H+ +S   S        +   +  + E 
Sbjct: 315 KREDQHQQKQSRDQENHYTDRDYRKERDSH-RHREASHRDSHWKRHEQEDKPRARDQRER 373

Query: 283 NNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHE 342
           +++  K ++ + K ++          E+++ +++      S      EK+K K   +K  
Sbjct: 374 SDRVWKREKDREKYSQ---------REQERDRQQNDQNRPSEKGEKEEKSKAKEEHMKVR 424

Query: 343 SSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGR-----EERSRRSRSRSPGS 397
             R ++   + D +K+    + S  +R  +RKE S  S  +     +ERS + R+ +   
Sbjct: 425 KERYENNDKYRDREKREVGVQSS--ERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDK 482

Query: 398 YKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYR 430
            + +E    ++ + G +     + +  G +  R
Sbjct: 483 ERNQEKPSNSESSLGAKHRLTEEGQEKGKEQER 515



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 39/195 (20%), Positives = 81/195 (41%), Gaps = 18/195 (9%)

Query: 235 KKKKDRKKKKFQKSRSKH-KKHKSSSSSSSSSSSSSSTETSESSSESES-NNKEKKIQRK 292
           +K++D  + +    R  H K+H+      +      S    +   + E  + +E++  R+
Sbjct: 338 RKERDSHRHREASHRDSHWKRHEQEDKPRARDQRERSDRVWKREKDREKYSQREQERDRQ 397

Query: 293 KRKKNKCSGHNNSDSEEKDKSKK-----RKLHEELSSSHHNREK------AKEKPRFLKH 341
           +  +N+ S     + EEK K+K+     RK   E +  + +REK      + E+ +  K 
Sbjct: 398 QNDQNRPS--EKGEKEEKSKAKEEHMKVRKERYENNDKYRDREKREVGVQSSERNQDRKE 455

Query: 342 ESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQR 401
            S    +K    D ++ ++    + +K  ++ K  +S S    +       +  G  ++R
Sbjct: 456 SSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTEEGQEKGKEQER 515

Query: 402 ---ETRKRAQRNPGE 413
                 K A+RN  E
Sbjct: 516 PPEAVSKFAKRNNEE 530



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 31/166 (18%), Positives = 71/166 (42%), Gaps = 13/166 (7%)

Query: 188 RNLTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQK 247
           R+   ND ++     E EE  +         K++   +RK +R E   K +DR+K++   
Sbjct: 394 RDRQQNDQNRPSEKGEKEEKSKA--------KEEHMKVRK-ERYENNDKYRDREKREVGV 444

Query: 248 SRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNN--S 305
             S+  + +  SS +S +      +   +   + + +KE+  ++    ++     +    
Sbjct: 445 QSSERNQDRKESSPNSRAKDKFLDQERSNKMRNMAKDKERNQEKPSNSESSLGAKHRLTE 504

Query: 306 DSEEKDKSKKRKLHEELSSSHHNREKA--KEKPRFLKHESSREDSK 349
           + +EK K ++R        +  N E+     + R+L  + +R ++K
Sbjct: 505 EGQEKGKEQERPPEAVSKFAKRNNEETVMSARDRYLARQMARVNAK 550


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 47/210 (22%), Positives = 86/210 (40%), Gaps = 14/210 (6%)

Query: 228 LDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEK 287
           ++ +E ++ K+D   ++  K R  HKK +               E  E   E     +E+
Sbjct: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEK-------ERQEIEKERRERERER 316

Query: 288 KIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSRED 347
           + +R++R++ +          E++K K+R+   E      +R++ KE+ R    E  R+ 
Sbjct: 317 ERERERRERER----EREREREREKEKERERERERD---RDRDRTKERDRDRDRERDRDR 369

Query: 348 SKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRA 407
            +   SD +K     +     R  ER+    R   RE    R R R     ++RE  K  
Sbjct: 370 DRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDK 429

Query: 408 QRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
           +R+  E++    + R     L   E  Y+E
Sbjct: 430 KRDREEDEEDAYERRKLERKLREKEAAYQE 459



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 46/240 (19%), Positives = 106/240 (44%), Gaps = 20/240 (8%)

Query: 201 ASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSS 260
           A E EED      + L +++  K      +LE++K KK++++++ +K R + ++ +    
Sbjct: 266 AIEMEEDK-----RDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERER---- 316

Query: 261 SSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKR---K 317
                      E  E   E E   + +K + ++R++ +    + +   ++D+ ++R   +
Sbjct: 317 -------ERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDR 369

Query: 318 LHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGS 377
             E  S  + +R +++EK R  + E  RE  +    + +++    +    +R  ER++  
Sbjct: 370 DRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDK 429

Query: 378 SRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
            R    +E     R +     +++E   + +R    E   R  +R +  +  R E+  RE
Sbjct: 430 KRDREEDEEDAYERRKLERKLREKEAAYQ-ERLKNWEIRERKKTREYEKEAEREEERRRE 488



 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 38/229 (16%), Positives = 99/229 (43%), Gaps = 7/229 (3%)

Query: 182 KRNVLGRNLTA-NDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDR 240
           KR+++ R ++   D  ++    +G+++ E + ++    +++++  R+ +R E++++++  
Sbjct: 273 KRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERERE 332

Query: 241 KKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS 300
           ++++ +K R + ++       +         E         S+++ K   R + K     
Sbjct: 333 REREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRE 392

Query: 301 GHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSR 360
                + E + + ++ +  E        RE+ +EK +    E   ED+ +     ++K R
Sbjct: 393 REREREREREREREREREREREREREREREREREKDKKRDREEDEEDA-YERRKLERKLR 451

Query: 361 THKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQR 409
             + + ++R  +  E   R   RE      R       ++RE  K A+R
Sbjct: 452 EKEAAYQER-LKNWEIRERKKTREYEKEAEREEE----RRREMAKEAKR 495



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 47/229 (20%), Positives = 95/229 (41%), Gaps = 26/229 (11%)

Query: 203 EGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSS 262
           E E + E E  K    +++++  R  DR +++ + +DR++ + +       ++K  S S 
Sbjct: 326 EREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSR 385

Query: 263 SSSSSSSSTETSESSSESE-----SNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRK 317
             S         E   E E        +E++ +R++ ++ +     + + +E+D  ++RK
Sbjct: 386 EKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRK 445

Query: 318 LHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGS 377
           L  +L      REK       LK+   RE          KK+R ++   E+    R+E +
Sbjct: 446 LERKL------REKEAAYQERLKNWEIRE---------RKKTREYEKEAEREEERRREMA 490

Query: 378 SRSHGREE------RSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRND 420
             +   +E        R       GS  Q+  R R +    +E+ R+ +
Sbjct: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKRE 539



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 48/229 (20%), Positives = 87/229 (37%), Gaps = 18/229 (7%)

Query: 226 RKLDRLEKKKKKKDRKKKKF-----QKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSES 280
           R  DR   ++K +DR++++      ++ R + ++ +               +      E 
Sbjct: 377 RNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREED 436

Query: 281 ESNNKEK-KIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELS-SSHHNREKAKEKPR- 337
           E +  E+ K++RK R+K         + E +++ K R+  +E        RE AKE  R 
Sbjct: 437 EEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRL 496

Query: 338 --FLK-HESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRS 394
             FL+ ++  R+D K+ +  S  + R      E    ER     +    E R R      
Sbjct: 497 KEFLEDYDDDRDDPKY-YRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGH 555

Query: 395 PG------SYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
           P         +Q   R+R  +   E +S   +      +  R E M  E
Sbjct: 556 PDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEE 604



 Score = 42.4 bits (98), Expect = 9e-04
 Identities = 54/221 (24%), Positives = 90/221 (40%), Gaps = 28/221 (12%)

Query: 211 EFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSS 270
           E+ +  +T +  +LL  L   EKK   K   K K Q    K KK     +S+ ++   + 
Sbjct: 133 EYKEPESTLRALRLLHDLQIGEKKLLVKVDAKTKAQLDEWKAKK----KASNGNARPETV 188

Query: 271 TETSESSSESESNNKEKKIQRKKRKK-NKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNR 329
           T   E + + E+  +++ I+        + S   N+ S+E D   ++K  E+        
Sbjct: 189 TNDDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRF 248

Query: 330 EKAKEKPRFLKHESSREDSKWSHSDSDKKSR----------THKHSPEKRGSERKEGSSR 379
             A   P  L    ++ED      + DK+            THK   E++G + KE   R
Sbjct: 249 PVAPLIPYPL---ITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKE---R 302

Query: 380 SHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRND 420
               +ER  R R R      +RE R+R +R    E+ R  +
Sbjct: 303 QEIEKERRERERER------ERE-RERRERERERERERERE 336



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 38/204 (18%), Positives = 88/204 (43%), Gaps = 18/204 (8%)

Query: 197 QEYVASEGEEDPEVEF--LKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKK 254
           ++ + +EG  DP+ E   ++    +++Q  +++    E+++++K  K++K ++   + ++
Sbjct: 547 RQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEE 606

Query: 255 HKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCS---GHNNSDSEEKD 311
            +       +    SS  +  S+S + + N           ++ C     H NS  +++ 
Sbjct: 607 PEQKPCLKPTLRPISSAPSVSSASGNATPNTPGD-------ESPCGIIIPHENSPDQQQP 659

Query: 312 KSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDS---KWSHSDSDKKSRTHKHSPEK 368
           +  + K+   L     N   +  +P  +K +    DS   K+   DSD   R  K  P  
Sbjct: 660 EEHRPKIGLSLKLGASN---SPGQPNSVKRKKLPVDSVFNKFEDEDSDDVPRKRKLVPLD 716

Query: 369 RGSERKEGSSRSHGREERSRRSRS 392
            G + K  +  +   EE+ +  +S
Sbjct: 717 YGEDDKNATKGTVNTEEKRKHIKS 740


>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 290

 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 40/236 (16%), Positives = 100/236 (42%), Gaps = 4/236 (1%)

Query: 190 LTANDPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSR 249
           L + +  + +   +  +D + +  +    + ++K  ++ DR  K+ +++ RK+K+  ++R
Sbjct: 54  LGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNR 113

Query: 250 SKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEE 309
            + K+ +               E           ++EK+ +R+  K     G   +++E 
Sbjct: 114 DREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDR--DGQRETETER 171

Query: 310 KDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKR 369
           +   ++ K  E  +    +R++  EK R  + ++ RE  +   + ++++  T +    + 
Sbjct: 172 ERDREREKQKERETERDRDRQRDTEKER--ERQTDRERDRQRKTQTERQRETDREGERET 229

Query: 370 GSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHG 425
              R+    R  G+E    R R       +++E +K  +    EE+ R +  R  G
Sbjct: 230 DRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKWG 285



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 47/216 (21%), Positives = 100/216 (46%), Gaps = 15/216 (6%)

Query: 226 RKLDRL-EKKKKKKDRKKKKFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNN 284
           R+ DR+ EK +K++DR +K+ ++ R K K+      ++ +      TE        +   
Sbjct: 79  RERDRVREKTEKERDRDRKRDRERRRKEKE------TNRNRDREKQTEIERDREREKQKG 132

Query: 285 KEKKIQR-KKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHES 343
           +E++  R ++R++++          EKD+  +R+   E      +RE+ K+K R  + E 
Sbjct: 133 RERERDRGRERERDRDREKERERQTEKDRDGQRETETE---RERDREREKQKER--ETER 187

Query: 344 SREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGRE--ERSRRSRSRSPGSYKQR 401
            R+  + +  + ++++   +    K  +ER+  + R   RE   R  R R R  G  + R
Sbjct: 188 DRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDR 247

Query: 402 ETRKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
           E  ++ +R    ++ R+ + +    +  R E   R+
Sbjct: 248 ERDRKEERKKERKKERKKERKEKKKEEKRREDKKRK 283



 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 38/168 (22%), Positives = 60/168 (35%), Gaps = 20/168 (11%)

Query: 290 QRKKRKKNKCSGHNNSDSE---------------EKDKSKKRKLHEELSSSHHNREKAKE 334
           Q   R       H ++D +               E+D+ +KR           NR + +E
Sbjct: 57  QESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDRE 116

Query: 335 KPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRS 394
           K   ++ +  RE  K    + D+     +    ++  ER+    R   RE  + R R R 
Sbjct: 117 KQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERDRE 176

Query: 395 PGSYKQRET-----RKRAQRNPGEEQSRRNDSRSHGTDLYRGEKMYRE 437
               K+RET     R+R      E Q+ R   R   T   R  +  RE
Sbjct: 177 REKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDRE 224


>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
          Length = 717

 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 71/239 (29%), Positives = 105/239 (43%), Gaps = 33/239 (13%)

Query: 189 NLTANDPSQEYVASEGEEDPE-----VEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKK 243
           +L    P+ +    +G   PE     VE +K LT    + +L      + K K + R + 
Sbjct: 506 SLAVLQPTPQVTQEQGHLLPERKDFPVESVK-LTEVPVEPVLTVHPESKSKTKTRSRSRG 564

Query: 244 KFQKSRSKHKKHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHN 303
           + +   SK +  +SSSSSSSSSSS+SS+  S SSS S S+             +  SG +
Sbjct: 565 RARNKTSKSRS-RSSSSSSSSSSSTSSSSGSSSSSGSSSSRSSSS------SSSSTSGSS 617

Query: 304 NSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHK 363
           + DS     S         SS   +R + +   R  KH  S +  +    D+    R+HK
Sbjct: 618 SRDSSSSTSS---------SSESRSRSRGRGHNRDRKHRRSVDRKR---RDTSGLERSHK 665

Query: 364 HSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSR 422
            S  K GS R    S+   +  RS R RS S  S     + KR+ R+  + +S R D R
Sbjct: 666 SS--KGGSSRDTKGSKD--KNSRSDRKRSISESS----RSGKRSSRSERDRKSDRKDKR 716



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 32/156 (20%), Positives = 54/156 (34%), Gaps = 17/156 (10%)

Query: 275 ESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSHHNREKAKE 334
           ES S++++ ++ +   R K  K++    ++S S     S          SS         
Sbjct: 551 ESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSSTSSSSGSSSSSGSS--------- 601

Query: 335 KPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRS 394
                   SSR  S  S S S   SR    S       R     R H R+ + RRS  R 
Sbjct: 602 --------SSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRGRGHNRDRKHRRSVDRK 653

Query: 395 PGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYR 430
                  E   ++ +      ++ +  ++  +D  R
Sbjct: 654 RRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSDRKR 689



 Score = 38.1 bits (87), Expect = 0.016
 Identities = 52/247 (21%), Positives = 92/247 (37%), Gaps = 17/247 (6%)

Query: 194 DPSQEYVASEGEEDPEVEFLKSLTTKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHK 253
           +PS+   + E E + E E       K        +  L+ +K+ +++++K+  + + +  
Sbjct: 415 EPSENEASKELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEKEEKE-SEPQPEPV 473

Query: 254 KHKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEE--KD 311
                 S       S S    +S   S+  +    + +   +  +  GH   + ++   +
Sbjct: 474 AQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGHLLPERKDFPVE 533

Query: 312 KSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGS 371
             K  ++  E   + H   K+K K R      +R  +  S S S   S +   S     +
Sbjct: 534 SVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSRSSSSSSSSSSS-----T 588

Query: 372 ERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRSHGTDLYRG 431
               GSS S G    S RS S S  S     +R  +       +SR   SRS G    RG
Sbjct: 589 SSSSGSSSSSGSS--SSRSSSSSSSSTSGSSSRDSSSSTSSSSESR---SRSRG----RG 639

Query: 432 EKMYREH 438
               R+H
Sbjct: 640 HNRDRKH 646


>gi|38488727 arginine/serine-rich coiled-coil 1 [Homo sapiens]
          Length = 334

 Score = 65.9 bits (159), Expect = 7e-11
 Identities = 51/154 (33%), Positives = 72/154 (46%), Gaps = 14/154 (9%)

Query: 301 GHNNSDSEEKDKSKKRKLHEELSSSH-------HNREKAKEKPRFLKHESSREDSKWSHS 353
           G  +SD+EE+ +SK++K H   SSS        ++R+K   K R      SR+    SHS
Sbjct: 2   GRRSSDTEEESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHS 61

Query: 354 DSDKKSRTHKHSPEKRGSERKEGSSRSHGREERSRRSRSRSPGSYKQRETRKRAQ---RN 410
             D++ R    S    GS RK   SRS GR +  R  RSRS    ++  +R R +   R+
Sbjct: 62  -YDRRRRHRSSSSSSYGSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRLRSHSRS 120

Query: 411 PGEEQSRRNDSRSHGTDLYRG---EKMYREHPGG 441
                 RR  SRS   +  +G   EK  +E   G
Sbjct: 121 SERSSHRRTRSRSRDRERRKGRDKEKREKEKDKG 154



 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 43/168 (25%), Positives = 76/168 (45%), Gaps = 16/168 (9%)

Query: 246 QKSRSKHKK--HKSSSSSSSSSSSSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHN 303
           ++SRSK KK   + SSSSSSS S + S +     S S+S +  + +Q +    ++   H 
Sbjct: 10  EESRSKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSYDRRRRHR 69

Query: 304 NSDSEEKDKSKKRKLHEELSSSHHNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHK 363
           +S S      +KR           +R +++ + +  + + SR  S+   S S  + R+H 
Sbjct: 70  SSSSSSYGSRRKR-----------SRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRLRSHS 118

Query: 364 HSPEKRGSERKEGSSRSHGR---EERSRRSRSRSPGSYKQRETRKRAQ 408
            S E+    R    SR   R    ++ +R + +  G  K+    KR +
Sbjct: 119 RSSERSSHRRTRSRSRDRERRKGRDKEKREKEKDKGKDKELHNIKRGE 166



 Score = 49.7 bits (117), Expect = 5e-06
 Identities = 49/217 (22%), Positives = 80/217 (36%), Gaps = 21/217 (9%)

Query: 218 TKQKQKLLRKLDRLEKKKKKKDRKKKKFQKSRSKHKK-----------HKSSSSSSSSSS 266
           +K+K+K  R+         +   +KK  +KSRSK +            +       SSSS
Sbjct: 14  SKRKKKHRRRSSSSSSSDSRTYSRKKGGRKSRSKSRSWSRDLQPRSHSYDRRRRHRSSSS 73

Query: 267 SSSSTETSESSSESESNNKEKKIQRKKRKKNKCSGHNNSDSEEKDKSKKRKLHEELSSSH 326
           SS  +    S S S    K  ++QR + K       +        +S +R  H    S  
Sbjct: 74  SSYGSRRKRSRSRSRGRGKSYRVQRSRSKSRTRRSRSRPRLRSHSRSSERSSHRRTRSRS 133

Query: 327 HNREKAKEKPRFLKHESSREDSKWSHSDSDKKSRTHKHSPEKRGSERKEGSSRSHGREER 386
            +RE+ K + +       RE  K    D  K    H     + G+  K G       E+ 
Sbjct: 134 RDRERRKGRDK-----EKREKEK----DKGKDKELHNIKRGESGN-IKAGLEHLPPAEQA 183

Query: 387 SRRSRSRSPGSYKQRETRKRAQRNPGEEQSRRNDSRS 423
             R +     + K  E  K  +RN  E + R+ + ++
Sbjct: 184 KARLQLVLEAAAKADEALKAKERNEEEAKRRKEEDQA 220


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.305    0.121    0.337 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,057,124
Number of Sequences: 37866
Number of extensions: 976890
Number of successful extensions: 31701
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 891
Number of HSP's successfully gapped in prelim test: 1034
Number of HSP's that attempted gapping in prelim test: 8450
Number of HSP's gapped (non-prelim): 10306
length of query: 450
length of database: 18,247,518
effective HSP length: 106
effective length of query: 344
effective length of database: 14,233,722
effective search space: 4896400368
effective search space used: 4896400368
T: 11
A: 40
X1: 16 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.9 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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