Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 39930351
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|39930351 dynamin binding protein [Homo sapiens]
(1577 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|39930351 dynamin binding protein [Homo sapiens] 3165 0.0
gi|83715966 hypothetical protein LOC389337 [Homo sapiens] 256 2e-67
gi|8923173 hypothetical protein LOC54848 [Homo sapiens] 118 4e-26
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 100 1e-20
gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [H... 97 1e-19
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 97 2e-19
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 96 2e-19
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 96 2e-19
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 94 8e-19
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 94 8e-19
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 94 1e-18
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 94 1e-18
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 94 1e-18
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 90 2e-17
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 90 2e-17
gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a ... 86 2e-16
gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b ... 85 5e-16
gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo ... 85 6e-16
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens] 84 1e-15
gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo s... 80 1e-14
gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo s... 80 1e-14
gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo sa... 80 1e-14
gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo s... 80 1e-14
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [... 80 1e-14
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [... 80 1e-14
gi|45439359 triple functional domain (PTPRF interacting) [Homo s... 80 2e-14
gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sap... 80 2e-14
gi|71274148 pleckstrin homology domain containing, family G (wit... 80 2e-14
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex... 79 3e-14
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 77 1e-13
>gi|39930351 dynamin binding protein [Homo sapiens]
Length = 1577
Score = 3165 bits (8207), Expect = 0.0
Identities = 1577/1577 (100%), Positives = 1577/1577 (100%)
Query: 1 MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT 60
MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT
Sbjct: 1 MEAGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT 60
Query: 61 IPSLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSC 120
IPSLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSC
Sbjct: 61 IPSLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSC 120
Query: 121 VRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEP 180
VRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEP
Sbjct: 121 VRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEP 180
Query: 181 GWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDED 240
GWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDED
Sbjct: 181 GWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDED 240
Query: 241 EEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLC 300
EEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLC
Sbjct: 241 EEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLC 300
Query: 301 PDTRVEETMALPQEGSLARIPETSLDCLENTLGVEEQRHETSDHEAEEPDCIISEAPTSP 360
PDTRVEETMALPQEGSLARIPETSLDCLENTLGVEEQRHETSDHEAEEPDCIISEAPTSP
Sbjct: 301 PDTRVEETMALPQEGSLARIPETSLDCLENTLGVEEQRHETSDHEAEEPDCIISEAPTSP 360
Query: 361 LGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEVVNGISSQPQVPF 420
LGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEVVNGISSQPQVPF
Sbjct: 361 LGHLTSEYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEVVNGISSQPQVPF 420
Query: 421 HPNLQKSQYYSTVGGSHPHSEQYPDLLPLEARTRDYASLPPKRMYSQLKTLQKPVLPLYR 480
HPNLQKSQYYSTVGGSHPHSEQYPDLLPLEARTRDYASLPPKRMYSQLKTLQKPVLPLYR
Sbjct: 421 HPNLQKSQYYSTVGGSHPHSEQYPDLLPLEARTRDYASLPPKRMYSQLKTLQKPVLPLYR 480
Query: 481 GSSVSASRVVKPRQSSPQLHNLASYTKKHHTSSVYSISERLEMKPGPQAQGLVMEAATHS 540
GSSVSASRVVKPRQSSPQLHNLASYTKKHHTSSVYSISERLEMKPGPQAQGLVMEAATHS
Sbjct: 481 GSSVSASRVVKPRQSSPQLHNLASYTKKHHTSSVYSISERLEMKPGPQAQGLVMEAATHS 540
Query: 541 QGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFSIMDFNSEKDIVRGSSKLITEQE 600
QGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFSIMDFNSEKDIVRGSSKLITEQE
Sbjct: 541 QGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFSIMDFNSEKDIVRGSSKLITEQE 600
Query: 601 LPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQRTNAVSP 660
LPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQRTNAVSP
Sbjct: 601 LPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVVRPSRPAPLPPSAQQRTNAVSP 660
Query: 661 KLLSRHRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLE 720
KLLSRHRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLE
Sbjct: 661 KLLSRHRPTCETLEKEGPGHMGRSLDQTSPCPLVLVRIEEMERDLDMYSRAQEELNLMLE 720
Query: 721 EKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQR 780
EKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQR
Sbjct: 721 EKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQR 780
Query: 781 MLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQ 840
MLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQ
Sbjct: 781 MLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQ 840
Query: 841 LLAALEISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADL 900
LLAALEISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADL
Sbjct: 841 LLAALEISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADL 900
Query: 901 KSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEI 960
KSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEI
Sbjct: 901 KSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEI 960
Query: 961 NVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKD 1020
NVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKD
Sbjct: 961 NVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHLKHLTGFAPQIKD 1020
Query: 1021 EVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQF 1080
EVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQF
Sbjct: 1021 EVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVKVVAAVSMWDVCMERGHRDLEQF 1080
Query: 1081 ERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEK 1140
ERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEK
Sbjct: 1081 ERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPHKLVQKRFDKLLDFYNCTERAEK 1140
Query: 1141 LKDKKTLEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQ 1200
LKDKKTLEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQ
Sbjct: 1141 LKDKKTLEELQSARNNYEALNAQLLDELPKFHQYAQGLFTNCVHGYAEAHCDFVHQALEQ 1200
Query: 1201 LKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSAR 1260
LKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSAR
Sbjct: 1201 LKPLLSLLKVAGREGNLIAIFHEEHSRVLQQLQVFTFFPESLPATKKPFERKTIDRQSAR 1260
Query: 1261 KPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDP 1320
KPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDP
Sbjct: 1261 KPLLGLPSYMLQSEELRASLLARYPPEKLFQAERNFNAAQDLDVSLLEGDLVGVIKKKDP 1320
Query: 1321 MGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASVGSHSSTESEHGSSSPRFPRQNSG 1380
MGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASVGSHSSTESEHGSSSPRFPRQNSG
Sbjct: 1321 MGSQNRWLIDNGVTKGFVYSSFLKPYNPRRSHSDASVGSHSSTESEHGSSSPRFPRQNSG 1380
Query: 1381 STLTFNPSSMAVSFTSGSCQKQPQDASPPPKECDQGTLSASLNPSNSESSPSRCPSDPDS 1440
STLTFNPSSMAVSFTSGSCQKQPQDASPPPKECDQGTLSASLNPSNSESSPSRCPSDPDS
Sbjct: 1381 STLTFNPSSMAVSFTSGSCQKQPQDASPPPKECDQGTLSASLNPSNSESSPSRCPSDPDS 1440
Query: 1441 TSQPRSGDSADVARDVKQPTATPRSYRNFRHPEIVGYSVPGRNGQSQDLVKGCARTAQAP 1500
TSQPRSGDSADVARDVKQPTATPRSYRNFRHPEIVGYSVPGRNGQSQDLVKGCARTAQAP
Sbjct: 1441 TSQPRSGDSADVARDVKQPTATPRSYRNFRHPEIVGYSVPGRNGQSQDLVKGCARTAQAP 1500
Query: 1501 EDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVN 1560
EDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVN
Sbjct: 1501 EDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVN 1560
Query: 1561 GKKGYVPSNYIRKTEYT 1577
GKKGYVPSNYIRKTEYT
Sbjct: 1561 GKKGYVPSNYIRKTEYT 1577
>gi|83715966 hypothetical protein LOC389337 [Homo sapiens]
Length = 675
Score = 256 bits (653), Expect = 2e-67
Identities = 176/592 (29%), Positives = 296/592 (50%), Gaps = 49/592 (8%)
Query: 769 SGSVSAEN--PEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEG 826
SGS E E R L + + EL+ TE Y+ L++C I +QQ +P D +
Sbjct: 13 SGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQ--LPQGDLDV 70
Query: 827 LFGNMQMVIKVSKQLLAALEISDA--------VGPVFLGHRDELEGTYKIYCQNHDEAIA 878
LF N+ +IKV+ + L L+ + + VG +FL ++ELE YK+YC ++D+A+
Sbjct: 71 LFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALL 130
Query: 879 LLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLN 938
L++ Y K+ ++Q+H+Q + + G L L+ P+QR+ RYPLLL ++L
Sbjct: 131 LVDTYRKEPELQRHIQGIVEAVVPQAGSSG------LSFLLVIPLQRITRYPLLLQKILE 184
Query: 939 STPESHPDKVPLTNAVLAVKEINVNINEYKRRKDLVLKYRKGDEDSLMEKISKLNIHSII 998
+T L AV A++++N NINEYK RK++ KY K ++ +L E+++++N H++
Sbjct: 185 NTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINTHTLS 244
Query: 999 KKSNRVSSHLKHLTGFAPQIKDEVFEETEKNFRMQERLIKSFIRDLSLYLQHIRESACVK 1058
KK+ R+S LK G P+ +D+ F++ E+ F+ + +++ YL +++ +
Sbjct: 245 KKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAFLYFR 304
Query: 1059 VVAAVSMWDVCMERGHRDLEQFERVHRYISDQLFTNFKERTERLVISPLNQLLSMFTGPH 1118
+ ++ Q+ + R + + F FK+R E LV PL L GP
Sbjct: 305 ------PHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQ 358
Query: 1119 KLVQKRFDKLLDFYNCTERAEKLKDKKTLEELQSARNNYEALNAQLLDELPKFHQYAQGL 1178
L++KR DKLLDF E+ ++ EE +AR+ Y+ALN+ L+ ELP+F+Q
Sbjct: 359 NLIKKRLDKLLDFERVEEKLLEVGSVTYQEE--AARHTYQALNSLLVAELPQFNQLVMQW 416
Query: 1179 FTNCVHGYAEAHCDFVHQALEQLKPLLSLLKVAG-REGNLIAIFHEEHSRVLQQLQVF-- 1235
+ + D Q L++ + ++ L E + + R QL+ F
Sbjct: 417 LGQIMCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQE 476
Query: 1236 TFFPESLPATKKPFERKTIDRQSARKPLLGLPSYMLQSEELRASLLARYPPEKLFQAERN 1295
TF P T +P LP SE +LL+RY P KL+Q N
Sbjct: 477 TFEKVQPPPTTQPL----------------LPG----SERQVQALLSRYGPGKLYQVTSN 516
Query: 1296 FNAAQDLDVSLLEGDLVGVIKKKDPMGSQNRWLIDNGVTKGFVYSSFLKPYN 1347
+ LD++L G +V +++ KD G+ RWL+D G +G+V + L+ Y+
Sbjct: 517 ISGTGTLDLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHRGYVPAGKLQLYH 568
Score = 61.2 bits (147), Expect = 7e-09
Identities = 30/59 (50%), Positives = 41/59 (69%), Gaps = 1/59 (1%)
Query: 1515 NQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRK 1573
NQV A Y F AR+ +E+S+ A Q + ILE +D GN EW L EVNG++GYVPS ++ +
Sbjct: 605 NQV-IAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFLAR 662
Score = 36.6 bits (83), Expect = 0.20
Identities = 15/42 (35%), Positives = 26/42 (61%)
Query: 1531 ELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIR 1572
+L++ Q + IL+ KD GN+ WL + G +GYVP+ ++
Sbjct: 524 DLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHRGYVPAGKLQ 565
Score = 33.5 bits (75), Expect = 1.7
Identities = 35/139 (25%), Positives = 56/139 (40%), Gaps = 25/139 (17%)
Query: 84 NLPLHRGDLV-ILDGIPTAG----WLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSA 138
+L L RG +V IL T G WL G RG+ P+ ++ + + + Q+
Sbjct: 524 DLTLPRGQIVAILQNKDTKGNSGRWLVDTG--GHRGYVPAGKLQLYHVVPSAEELRRQAG 581
Query: 139 LFQIPEY--------------SMGQARALMGLSAQLDEELDFREGDVITIIGVPE----P 180
L + P +M Q A A+ E+ + G +TI+ + P
Sbjct: 582 LNKDPRCLTPEPSPALVPSIPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNP 641
Query: 181 GWFEGELEGRRGIFPEGFV 199
W E+ G+RG P GF+
Sbjct: 642 EWSLVEVNGQRGYVPSGFL 660
>gi|8923173 hypothetical protein LOC54848 [Homo sapiens]
Length = 219
Score = 118 bits (296), Expect = 4e-26
Identities = 62/175 (35%), Positives = 105/175 (60%), Gaps = 13/175 (7%)
Query: 735 LKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQ 794
L+ +S+ N +LQ+ ++ Q VA + + E+ +RM+ KR K+I+EL+Q
Sbjct: 50 LRRSQSDRTEYNQKLQEK-----MTPQGECSVAETLTPEEEHHMKRMMAKREKIIKELIQ 104
Query: 795 TERDYIRDLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALE-------- 846
TE+DY+ DLE+C+ ++ P++ + +D + LF N++ V ++S +LL+ LE
Sbjct: 105 TEKDYLNDLELCVREVVQPLRNKKTDRLDVDSLFSNIESVHQISAKLLSLLEEATTDVEP 164
Query: 847 ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLK 901
+G VFL + LE YKIYC +HDEA ++LE YEK+E++++HL + LK
Sbjct: 165 AMQVIGEVFLQIKGPLEDIYKIYCYHHDEAHSILESYEKEEELKEHLSHCIQSLK 219
>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
exchange factor 1 [Homo sapiens]
Length = 1659
Score = 100 bits (249), Expect = 1e-20
Identities = 72/224 (32%), Positives = 111/224 (49%), Gaps = 25/224 (11%)
Query: 767 APS---GSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNID 823
APS G +A +R L R V+ E+L TERDY+ L + ++Q +++
Sbjct: 29 APSSGPGPCAAARESERQLRLRLCVLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVE 88
Query: 824 -------FEGLFGNMQMVIKVSKQLLAALEI--------SDAVGPVFLGHRDELEGTYKI 868
+ LF N++ +++V K LAALE +G VFL +D+ Y+
Sbjct: 89 KGLTEENVKVLFSNIEDILEVHKDFLAALEYCLHPEPQSQHELGNVFLKFKDKF-CVYEE 147
Query: 869 YCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMR 928
YC NH++A+ LL K ++ L L + T I L +L+ P+QR+ +
Sbjct: 148 YCSNHEKALRLLVELNKIPTVRAFL------LSCMLLGGRKTTDIPLEGYLLSPIQRICK 201
Query: 929 YPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKD 972
YPLLL EL TP HPD + +A+ A+K + NINE KR+ +
Sbjct: 202 YPLLLKELAKRTPGKHPDHPAVQSALQAMKTVCSNINETKRQME 245
>gi|242117953 SH3 domain-containing protein C1orf113 isoform 1 [Homo
sapiens]
Length = 756
Score = 97.1 bits (240), Expect = 1e-19
Identities = 185/799 (23%), Positives = 310/799 (38%), Gaps = 112/799 (14%)
Query: 77 FTSQELDNLPLHRGDLVI-LDGIPTAGWLQGRSCWGARGFFPSSCVRE----LCLSSQSR 131
+ +Q+ D L L GD+V + +P GWL+G G G FP V+E L S ++R
Sbjct: 9 YRAQKEDELSLAPGDVVRQVRWVPARGWLRGEF-GGRYGLFPERLVQEIPETLRGSGEAR 67
Query: 132 QWHSQSALFQIPEYSMGQ--ARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG 189
+ ++ Q + S + +EL + G+++ +I E GW+ G+ G
Sbjct: 68 RPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNG 127
Query: 190 RRGIFPEGFVELL--GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEE----- 242
+ G FP FVELL GP S GN D V+ P + D +
Sbjct: 128 QLGAFPSNFVELLDSGP-------PSLGNPDMPSVSPGPQRPPKLSSLAYDSPPDYLQTV 180
Query: 243 -EPGTYGVALYRFQALEPNELDFEVGDKIRILA-TLED-GWLEGSLKGRTGIFPYRFV-- 297
P Y V L+ +Q P+EL GD +++L+ T ED GW EG +GR G+FP FV
Sbjct: 181 SHPEVYRV-LFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFVLP 239
Query: 298 -----KLCPDTRVEETMALPQEGSLARIPETSLDCLEN--TLGVEEQRHETSDHEAEEPD 350
KL P +V + P + +P+TSL ++ T + +TS + +
Sbjct: 240 PPPIKKLVP-RKVVSRESAPIKEPKKLMPKTSLPTVKKLATATTGPSKAKTSRTPSRDSQ 298
Query: 351 CIISEAPTSPLGHLTS--EYDTDRNSYQDEDTAGGPPRSPGVEWEMPLATDSPTSDPTEV 408
+ S + P G S Y R + + S E P+ S P
Sbjct: 299 KLTSR-DSGPNGGFQSGGSYHPGRKRSKTQTPQQRSVSSQEEEHSSPVKAPSVKRTPMPD 357
Query: 409 VNGISSQPQVPFHPNLQKSQYYSTVGGSHPHSEQYPDLLPLEART---RDYASLPPKRMY 465
+P P N S+ PD +P +T D AS+P
Sbjct: 358 KTATPERPPAP--ENAPSSKKIPA-----------PDKVPSPEKTLTLGDKASIPGNSTS 404
Query: 466 SQLKTLQKPVLPLYRGSSVSASRVVKP--RQSSPQLHNLASYT----KKHHTSSVYSISE 519
++ K P ++V P + S P+ + T K V+S+ E
Sbjct: 405 GKIPAPDKVPTP---------EKMVTPEDKASIPENSIIPEETLTVDKPSTPERVFSVEE 455
Query: 520 RLEMKPGPQAQGLVMEAATHSQGDGSTDLDSKLTQQLIEFEKSLAGPGTEPDKILRHFSI 579
++ P + V GD + L+ LT +L E E S T D HF
Sbjct: 456 SPALEAPPMDK--VPNPKMAPLGDEAPTLEKVLTPELSEEEVS-----TRDDIQFHHF-- 506
Query: 580 MDFNSEKDIVRGSSKLITEQELPERRKALRPPPPRPCTPVSTSPHLLVDQNLKPAPPLVV 639
S ++ ++ + +++ + +A P P P P S ++ L +V
Sbjct: 507 ----SSEEALQKVKYFVAKEDPSSQEEAHTPEAPPPQPPSS-------ERCLGEMKCTLV 555
Query: 640 RPSRPAPLPPSAQQRTNAVSPKLLSRHRPTCE--TLEKEGPGHMGRSLDQTSPCPLVLVR 697
R P A+ ++ S L + P E TL +E P + R+ ++ +P
Sbjct: 556 RGDSS---PRQAELKSGPASRPALEKPHPHEEATTLPEEAPSNDERTPEEEAPPNEQRPL 612
Query: 698 IEEMERDLDMYSRAQEELNLMLEEKQD----------ESSRAETLEDLKFCESNIESLNM 747
EE+ + S+ + L L K++ E + A+ +K + E+L +
Sbjct: 613 REEVLPKEGVASKEEVTLKEELPPKEEVAPKEEVPPIERAFAQKTRPIKPPPDSQETLAL 672
Query: 748 ELQQLREMTLLSSQSSSLVAPSGSVS----AENPEQRMLEKRAKVIEELLQTERDYIRDL 803
+ T ++ + + G V A + LE++ I E L++E++ R L
Sbjct: 673 PSLVPQNYTENKNEGVDVTSLRGEVESLRRALELMEVQLERKLTDIWEELKSEKEQRRRL 732
Query: 804 EMCIERIMVPMQQAQVPNI 822
E+ ++M Q++Q P +
Sbjct: 733 EV---QVMQGTQKSQTPRV 748
Score = 68.2 bits (165), Expect = 6e-11
Identities = 43/148 (29%), Positives = 66/148 (44%), Gaps = 15/148 (10%)
Query: 153 LMGLSAQLDEELDFREGDVITIIG-VPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDES 211
L G AQ ++EL GDV+ + VP GW GE GR G+FPE V+ + E+
Sbjct: 6 LAGYRAQKEDELSLAPGDVVRQVRWVPARGWLRGEFGGRYGLFPERLVQ------EIPET 59
Query: 212 VSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIR 271
+ +GE P G P + + + + +EL + G+ +
Sbjct: 60 LRG--------SGEARRPRCARRRGHPAKHPRPQRWCKVNFSYSPEQADELKLQAGEIVE 111
Query: 272 ILATLEDGWLEGSLKGRTGIFPYRFVKL 299
++ +EDGW G G+ G FP FV+L
Sbjct: 112 MIKEIEDGWWLGKKNGQLGAFPSNFVEL 139
Score = 59.3 bits (142), Expect = 3e-08
Identities = 41/147 (27%), Positives = 67/147 (45%), Gaps = 37/147 (25%)
Query: 11 FDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIV----------T 60
F + P ++EL L G+I+E++ +++ W LGKK G FPS+FVE++
Sbjct: 92 FSYSPEQADELKLQAGEIVEMIKEIEDGWWLGKKNGQLGAFPSNFVELLDSGPPSLGNPD 151
Query: 61 IPSLKEGER------------------------LFVCICEFTSQELDNLPLHRGDLVILD 96
+PS+ G + ++ + ++ + D L L RGD+V +
Sbjct: 152 MPSVSPGPQRPPKLSSLAYDSPPDYLQTVSHPEVYRVLFDYQPEAPDELALRRGDVVKVL 211
Query: 97 GIPT--AGWLQGRSCWGARGFFPSSCV 121
T GW +G C G RG FP + V
Sbjct: 212 SKTTEDKGWWEG-ECQGRRGVFPDNFV 237
Score = 38.5 bits (88), Expect = 0.052
Identities = 20/53 (37%), Positives = 31/53 (58%), Gaps = 2/53 (3%)
Query: 6 VVRAIFDFCPSVSEELPLFVGDIIEVLA--VVDEFWLLGKKEDVTGQFPSSFV 56
V R +FD+ P +EL L GD+++VL+ D+ W G+ + G FP +FV
Sbjct: 185 VYRVLFDYQPEAPDELALRRGDVVKVLSKTTEDKGWWEGECQGRRGVFPDNFV 237
Score = 37.4 bits (85), Expect = 0.12
Identities = 15/56 (26%), Positives = 30/56 (53%), Gaps = 2/56 (3%)
Query: 1516 QVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYI 1571
+VY ++ ++ P+EL++ +K+L T + WW E G++G P N++
Sbjct: 184 EVYRVLFDYQPEAPDELALRRGDVVKVLS--KTTEDKGWWEGECQGRRGVFPDNFV 237
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 96.7 bits (239), Expect = 2e-19
Identities = 85/317 (26%), Positives = 146/317 (46%), Gaps = 30/317 (9%)
Query: 20 ELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI-----------PS----- 63
EL GD++ +L + +L +K + TG+ S ++I+T PS
Sbjct: 433 ELSCKRGDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKP 492
Query: 64 LKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRE 123
+ G V + +F ++++D+L L G++V L W +G +C G FP++ V+
Sbjct: 493 VDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQIGIFPANYVKV 551
Query: 124 LCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWF 183
+ + + + S AR + +EL F EG++I + W
Sbjct: 552 IIDIPEGGNGKRECVSSHCVKGSRCVAR--FEYIGEQKDELSFSEGEIIILKEYVNEEWA 609
Query: 184 EGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEE 243
GE+ GR GIFP FVE V++ +SG +++ +V +E+ G +
Sbjct: 610 RGEVRGRTGIFPLNFVE------PVEDYPTSGAN---VLSTKVPLKTKKEDSGSNSQVNS 660
Query: 244 -PGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPD 302
P + AL+ F A ++L F+ GD+I+IL L+ W G L+ R GIFP FV+ CP
Sbjct: 661 LPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP- 719
Query: 303 TRVEETMALPQEGSLAR 319
+ +A+ +G A+
Sbjct: 720 AEAKSMLAIVPKGRKAK 736
Score = 94.7 bits (234), Expect = 6e-19
Identities = 82/316 (25%), Positives = 134/316 (42%), Gaps = 60/316 (18%)
Query: 10 IFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVE-IVTIPSLKEGE 68
+ DF ++L L G+I+ +L +D W G + G FP+++V+ I+ IP G+
Sbjct: 503 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGK 562
Query: 69 RLFV---------CIC--EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFP 117
R V C+ E+ ++ D L G+++IL W +G G G FP
Sbjct: 563 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARG-EVRGRTGIFP 621
Query: 118 SSCVR---------------ELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDE 162
+ V ++ L ++ S S + +P AL +A+ +
Sbjct: 622 LNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP---AEWCEALHSFTAETSD 678
Query: 163 ELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIV 222
+L F+ GD I I+ + W G L+ R GIFP FV P +S+ +
Sbjct: 679 DLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR---PCPAEAKSMLA-------- 727
Query: 223 NGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLE 282
I P G ALY F+ +EL F+ GD I L +++D W+
Sbjct: 728 ------------IVP------KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMS 769
Query: 283 GSLKGRTGIFPYRFVK 298
G L G++GIFP +++
Sbjct: 770 GELMGKSGIFPKNYIQ 785
Score = 73.2 bits (178), Expect = 2e-12
Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 36/225 (16%)
Query: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT--- 60
GS A F++ +EL G+II + V+E W G+ TG FP +FVE V
Sbjct: 573 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 632
Query: 61 ----------IP---------SLKEGERLFVCICE----FTSQELDNLPLHRGDLVILDG 97
+P S + L CE FT++ D+L RGD + +
Sbjct: 633 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 692
Query: 98 IPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLS 157
+ W +GR G FP+ VR C + ++S L +P+ +A+AL
Sbjct: 693 RLDSDWCRGR-LQDREGIFPAVFVRP-CPAE------AKSMLAIVPKGR--KAKALYDFR 742
Query: 158 AQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL 202
+ ++EL F+ GD+IT + + W GEL G+ GIFP+ +++ L
Sbjct: 743 GENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 40.4 bits (93), Expect = 0.014
Identities = 19/58 (32%), Positives = 32/58 (55%)
Query: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI 61
G +A++DF +EL GDII L VD+ W+ G+ +G FP ++++ + I
Sbjct: 732 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQI 789
Score = 38.1 bits (87), Expect = 0.068
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Query: 1497 AQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWL 1556
A+A + P G +A+ A+Y F+ N +ELS A + LE D +W
Sbjct: 720 AEAKSMLAIVPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVD----DDWMS 769
Query: 1557 AEVNGKKGYVPSNYIR 1572
E+ GK G P NYI+
Sbjct: 770 GELMGKSGIFPKNYIQ 785
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 96.3 bits (238), Expect = 2e-19
Identities = 83/311 (26%), Positives = 144/311 (46%), Gaps = 30/311 (9%)
Query: 26 GDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI-----------PS-----LKEGER 69
GD++ +L + +L +K + TG+ S ++I+T PS + G
Sbjct: 380 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAP 439
Query: 70 LFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
V + +F ++++D+L L G++V L W +G +C G FP++ V+ + +
Sbjct: 440 HAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQIGIFPANYVKVIIDIPE 498
Query: 130 SRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG 189
+ + S AR + +EL F EG++I + W GE+ G
Sbjct: 499 GGNGKRECVSSHCVKGSRCVAR--FEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 556
Query: 190 RRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEE-PGTYG 248
R GIFP FVE V++ +SG +++ +V +E+ G + P +
Sbjct: 557 RTGIFPLNFVE------PVEDYPTSGAN---VLSTKVPLKTKKEDSGSNSQVNSLPAEWC 607
Query: 249 VALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEET 308
AL+ F A ++L F+ GD+I+IL L+ W G L+ R GIFP FV+ CP +
Sbjct: 608 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP-AEAKSM 666
Query: 309 MALPQEGSLAR 319
+A+ +G A+
Sbjct: 667 LAIVPKGRKAK 677
Score = 94.7 bits (234), Expect = 6e-19
Identities = 82/316 (25%), Positives = 134/316 (42%), Gaps = 60/316 (18%)
Query: 10 IFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVE-IVTIPSLKEGE 68
+ DF ++L L G+I+ +L +D W G + G FP+++V+ I+ IP G+
Sbjct: 444 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGK 503
Query: 69 RLFV---------CIC--EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFP 117
R V C+ E+ ++ D L G+++IL W +G G G FP
Sbjct: 504 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARG-EVRGRTGIFP 562
Query: 118 SSCVR---------------ELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDE 162
+ V ++ L ++ S S + +P AL +A+ +
Sbjct: 563 LNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP---AEWCEALHSFTAETSD 619
Query: 163 ELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIV 222
+L F+ GD I I+ + W G L+ R GIFP FV P +S+ +
Sbjct: 620 DLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR---PCPAEAKSMLA-------- 668
Query: 223 NGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLE 282
I P G ALY F+ +EL F+ GD I L +++D W+
Sbjct: 669 ------------IVP------KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMS 710
Query: 283 GSLKGRTGIFPYRFVK 298
G L G++GIFP +++
Sbjct: 711 GELMGKSGIFPKNYIQ 726
Score = 73.2 bits (178), Expect = 2e-12
Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 36/225 (16%)
Query: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT--- 60
GS A F++ +EL G+II + V+E W G+ TG FP +FVE V
Sbjct: 514 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 573
Query: 61 ----------IP---------SLKEGERLFVCICE----FTSQELDNLPLHRGDLVILDG 97
+P S + L CE FT++ D+L RGD + +
Sbjct: 574 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 633
Query: 98 IPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLS 157
+ W +GR G FP+ VR C + ++S L +P+ +A+AL
Sbjct: 634 RLDSDWCRGR-LQDREGIFPAVFVRP-CPAE------AKSMLAIVPKGR--KAKALYDFR 683
Query: 158 AQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL 202
+ ++EL F+ GD+IT + + W GEL G+ GIFP+ +++ L
Sbjct: 684 GENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 40.4 bits (93), Expect = 0.014
Identities = 19/58 (32%), Positives = 32/58 (55%)
Query: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI 61
G +A++DF +EL GDII L VD+ W+ G+ +G FP ++++ + I
Sbjct: 673 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQI 730
Score = 38.1 bits (87), Expect = 0.068
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Query: 1497 AQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWL 1556
A+A + P G +A+ A+Y F+ N +ELS A + LE D +W
Sbjct: 661 AEAKSMLAIVPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVD----DDWMS 710
Query: 1557 AEVNGKKGYVPSNYIR 1572
E+ GK G P NYI+
Sbjct: 711 GELMGKSGIFPKNYIQ 726
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 96.3 bits (238), Expect = 2e-19
Identities = 83/311 (26%), Positives = 144/311 (46%), Gaps = 30/311 (9%)
Query: 26 GDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI-----------PS-----LKEGER 69
GD++ +L + +L +K + TG+ S ++I+T PS + G
Sbjct: 416 GDVLVMLKQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAP 475
Query: 70 LFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQ 129
V + +F ++++D+L L G++V L W +G +C G FP++ V+ + +
Sbjct: 476 HAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRG-NCRNQIGIFPANYVKVIIDIPE 534
Query: 130 SRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG 189
+ + S AR + +EL F EG++I + W GE+ G
Sbjct: 535 GGNGKRECVSSHCVKGSRCVAR--FEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRG 592
Query: 190 RRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEE-PGTYG 248
R GIFP FVE V++ +SG +++ +V +E+ G + P +
Sbjct: 593 RTGIFPLNFVE------PVEDYPTSGAN---VLSTKVPLKTKKEDSGSNSQVNSLPAEWC 643
Query: 249 VALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEET 308
AL+ F A ++L F+ GD+I+IL L+ W G L+ R GIFP FV+ CP +
Sbjct: 644 EALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCP-AEAKSM 702
Query: 309 MALPQEGSLAR 319
+A+ +G A+
Sbjct: 703 LAIVPKGRKAK 713
Score = 94.7 bits (234), Expect = 6e-19
Identities = 82/316 (25%), Positives = 134/316 (42%), Gaps = 60/316 (18%)
Query: 10 IFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVE-IVTIPSLKEGE 68
+ DF ++L L G+I+ +L +D W G + G FP+++V+ I+ IP G+
Sbjct: 480 LHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGK 539
Query: 69 RLFV---------CIC--EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFP 117
R V C+ E+ ++ D L G+++IL W +G G G FP
Sbjct: 540 RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARG-EVRGRTGIFP 598
Query: 118 SSCVR---------------ELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDE 162
+ V ++ L ++ S S + +P AL +A+ +
Sbjct: 599 LNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLP---AEWCEALHSFTAETSD 655
Query: 163 ELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIV 222
+L F+ GD I I+ + W G L+ R GIFP FV P +S+ +
Sbjct: 656 DLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR---PCPAEAKSMLA-------- 704
Query: 223 NGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLE 282
I P G ALY F+ +EL F+ GD I L +++D W+
Sbjct: 705 ------------IVP------KGRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMS 746
Query: 283 GSLKGRTGIFPYRFVK 298
G L G++GIFP +++
Sbjct: 747 GELMGKSGIFPKNYIQ 762
Score = 73.2 bits (178), Expect = 2e-12
Identities = 65/225 (28%), Positives = 102/225 (45%), Gaps = 36/225 (16%)
Query: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT--- 60
GS A F++ +EL G+II + V+E W G+ TG FP +FVE V
Sbjct: 550 GSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYP 609
Query: 61 ----------IP---------SLKEGERLFVCICE----FTSQELDNLPLHRGDLVILDG 97
+P S + L CE FT++ D+L RGD + +
Sbjct: 610 TSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILE 669
Query: 98 IPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLS 157
+ W +GR G FP+ VR C + ++S L +P+ +A+AL
Sbjct: 670 RLDSDWCRGR-LQDREGIFPAVFVRP-CPAE------AKSMLAIVPKGR--KAKALYDFR 719
Query: 158 AQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL 202
+ ++EL F+ GD+IT + + W GEL G+ GIFP+ +++ L
Sbjct: 720 GENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 40.4 bits (93), Expect = 0.014
Identities = 19/58 (32%), Positives = 32/58 (55%)
Query: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTI 61
G +A++DF +EL GDII L VD+ W+ G+ +G FP ++++ + I
Sbjct: 709 GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPKNYIQFLQI 766
Score = 38.1 bits (87), Expect = 0.068
Identities = 25/76 (32%), Positives = 36/76 (47%), Gaps = 10/76 (13%)
Query: 1497 AQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWL 1556
A+A + P G +A+ A+Y F+ N +ELS A + LE D +W
Sbjct: 697 AEAKSMLAIVPKGRKAK------ALYDFRGENEDELSFKAGDIITELESVD----DDWMS 746
Query: 1557 AEVNGKKGYVPSNYIR 1572
E+ GK G P NYI+
Sbjct: 747 GELMGKSGIFPKNYIQ 762
>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
Length = 979
Score = 94.4 bits (233), Expect = 8e-19
Identities = 65/209 (31%), Positives = 100/209 (47%), Gaps = 22/209 (10%)
Query: 779 QRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNID-------FEGLFGNM 831
++ L R V+ EL +TERDY+ LE + + M Q +D + LF N+
Sbjct: 18 EKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNI 77
Query: 832 QMVIKVSKQLLAALE--------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIY 883
+ ++ V K+ L +E VG FL +D+ Y YC NH++A LL
Sbjct: 78 EDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLEL 136
Query: 884 EKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPES 943
K I+ L + + L N + L +L+ P+QR+ +YPL+L ELL TP
Sbjct: 137 NKIRTIRTFLLNCML-LGGRKN-----TDVPLEGYLVTPIQRICKYPLILKELLKRTPRK 190
Query: 944 HPDKVPLTNAVLAVKEINVNINEYKRRKD 972
H D + A+ A+K + NINE KR+ +
Sbjct: 191 HSDYAAVMEALQAMKAVCSNINEAKRQME 219
>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
Length = 1606
Score = 94.4 bits (233), Expect = 8e-19
Identities = 65/209 (31%), Positives = 100/209 (47%), Gaps = 22/209 (10%)
Query: 779 QRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNID-------FEGLFGNM 831
++ L R V+ EL +TERDY+ LE + + M Q +D + LF N+
Sbjct: 18 EKQLRLRVCVLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNI 77
Query: 832 QMVIKVSKQLLAALE--------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIY 883
+ ++ V K+ L +E VG FL +D+ Y YC NH++A LL
Sbjct: 78 EDILAVHKEFLKVVEECLHPEPNAQQEVGTCFLHFKDKFR-IYDEYCSNHEKAQKLLLEL 136
Query: 884 EKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPES 943
K I+ L + + L N + L +L+ P+QR+ +YPL+L ELL TP
Sbjct: 137 NKIRTIRTFLLNCML-LGGRKN-----TDVPLEGYLVTPIQRICKYPLILKELLKRTPRK 190
Query: 944 HPDKVPLTNAVLAVKEINVNINEYKRRKD 972
H D + A+ A+K + NINE KR+ +
Sbjct: 191 HSDYAAVMEALQAMKAVCSNINEAKRQME 219
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
sapiens]
Length = 532
Score = 93.6 bits (231), Expect = 1e-18
Identities = 71/239 (29%), Positives = 118/239 (49%), Gaps = 23/239 (9%)
Query: 784 KRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQV-PNIDFEGLFGNMQMVIKVSKQLL 842
KR + I EL Q E D I DL++ + PM + + + +FG + +I + ++LL
Sbjct: 128 KRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELL 187
Query: 843 AALE-------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD 895
+ L ++ VGP+ +G L +Y YC N A ALL+ ++D ++Q LQ
Sbjct: 188 SQLRDVRKPDGSTEHVGPILVGWLPCLS-SYDSYCSNQVAAKALLDHKKQDHRVQDFLQR 246
Query: 896 SLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVL 955
L E + ++L +FL P R+++YPLLL E+L TP +PD+ L A+
Sbjct: 247 CL--------ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAIN 298
Query: 956 AVKEINVNIN------EYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHL 1008
++ I IN E + K+ +L +G +DSL++ L H +K + V H+
Sbjct: 299 IIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHV 357
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
sapiens]
Length = 558
Score = 93.6 bits (231), Expect = 1e-18
Identities = 71/239 (29%), Positives = 118/239 (49%), Gaps = 23/239 (9%)
Query: 784 KRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQV-PNIDFEGLFGNMQMVIKVSKQLL 842
KR + I EL Q E D I DL++ + PM + + + +FG + +I + ++LL
Sbjct: 154 KRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELL 213
Query: 843 AALE-------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD 895
+ L ++ VGP+ +G L +Y YC N A ALL+ ++D ++Q LQ
Sbjct: 214 SQLRDVRKPDGSTEHVGPILVGWLPCLS-SYDSYCSNQVAAKALLDHKKQDHRVQDFLQR 272
Query: 896 SLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVL 955
L E + ++L +FL P R+++YPLLL E+L TP +PD+ L A+
Sbjct: 273 CL--------ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAIN 324
Query: 956 AVKEINVNIN------EYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHL 1008
++ I IN E + K+ +L +G +DSL++ L H +K + V H+
Sbjct: 325 IIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHV 383
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 93.6 bits (231), Expect = 1e-18
Identities = 71/239 (29%), Positives = 118/239 (49%), Gaps = 23/239 (9%)
Query: 784 KRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQV-PNIDFEGLFGNMQMVIKVSKQLL 842
KR + I EL Q E D I DL++ + PM + + + +FG + +I + ++LL
Sbjct: 122 KRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELL 181
Query: 843 AALE-------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQD 895
+ L ++ VGP+ +G L +Y YC N A ALL+ ++D ++Q LQ
Sbjct: 182 SQLRDVRKPDGSTEHVGPILVGWLPCLS-SYDSYCSNQVAAKALLDHKKQDHRVQDFLQR 240
Query: 896 SLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVL 955
L E + ++L +FL P R+++YPLLL E+L TP +PD+ L A+
Sbjct: 241 CL--------ESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAIN 292
Query: 956 AVKEINVNIN------EYKRRKDLVLKYRKGDEDSLMEKISKLNIHSIIKKSNRVSSHL 1008
++ I IN E + K+ +L +G +DSL++ L H +K + V H+
Sbjct: 293 IIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHV 351
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 90.1 bits (222), Expect = 2e-17
Identities = 95/350 (27%), Positives = 152/350 (43%), Gaps = 53/350 (15%)
Query: 8 RAIFDFCPSVSEELPLFVGDIIEVLAV-VDEF------WLLGKKEDVTGQFPSSFVEIVT 60
RA++ F +E+ + GDI+ V VDE WL G+ + TG FP+++ E
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE--K 803
Query: 61 IPSLKEGERLFVCICEFTSQELDNLPLHR--GDLVILDGIPTA---GWLQGRSC------ 109
IP E + + TS L L L + P+ W S
Sbjct: 804 IPE-NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTN 862
Query: 110 -------WGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQL-- 160
W A PS V Q + +A P +GQ + GL AQ
Sbjct: 863 EKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALY 922
Query: 161 ------DEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL-GPLRTVDESVS 213
D L+F + DVIT++ + WF GE++G++G FP+ +V+L+ GP+R S+
Sbjct: 923 PWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRK-STSMD 980
Query: 214 SGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRIL 273
SG+ + V +P + + +E +A+Y +++ E +L F+ GD IL
Sbjct: 981 SGSSESPASLKRVASPAAKPVVSGEE--------FIAMYTYESSEQGDLTFQQGDV--IL 1030
Query: 274 ATLEDG-WLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPE 322
T +DG W G++ + G+FP +V+L E + + GSL + PE
Sbjct: 1031 VTKKDGDWWTGTVGDKAGVFPSNYVRLKDS---EGSGTAGKTGSLGKKPE 1077
Score = 77.8 bits (190), Expect = 8e-14
Identities = 85/335 (25%), Positives = 132/335 (39%), Gaps = 71/335 (21%)
Query: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIP- 62
G +A++ + L D+I VL D +W G+ + G FP S+V++++ P
Sbjct: 915 GLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPI 973
Query: 63 ---------------SLKE-----------GERLFVCICEFTSQELDNLPLHRGDLVILD 96
SLK GE F+ + + S E +L +GD++++
Sbjct: 974 RKSTSMDSGSSESPASLKRVASPAAKPVVSGEE-FIAMYTYESSEQGDLTFQQGDVILVT 1032
Query: 97 GIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGL 156
W G + G FPS+ VR L S S +L + PE A+ +
Sbjct: 1033 K-KDGDWWTG-TVGDKAGVFPSNYVR-LKDSEGSGTAGKTGSLGKKPEI----AQVIASY 1085
Query: 157 SAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR-----GIFPEGFVELLGPLRTVDES 211
+A E+L G +I I GW+EGEL+ R G FP +V+LL P
Sbjct: 1086 TATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP------- 1138
Query: 212 VSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVA----LYRFQALEPNELDFEVG 267
G +I P E + V +Y + A +EL F G
Sbjct: 1139 -------------------GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKG 1179
Query: 268 DKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPD 302
I +L + W +G + G+ G+FP +VKL D
Sbjct: 1180 QIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTD 1214
Score = 68.2 bits (165), Expect = 6e-11
Identities = 54/212 (25%), Positives = 96/212 (45%), Gaps = 16/212 (7%)
Query: 3 AGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIP 62
+G A++ + S +L GD+I ++ D W G D G FPS++V +
Sbjct: 1003 SGEEFIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSE 1061
Query: 63 ---------SLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGW----LQGRSC 109
SL + + I +T+ + L L G L+++ GW LQ R
Sbjct: 1062 GSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGK 1121
Query: 110 WGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREG 169
G+FP++ V+ LS + + ++ Q + +AQ D+EL F +G
Sbjct: 1122 KRQIGWFPANYVK--LLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKG 1179
Query: 170 DVITIIGVPEPGWFEGELEGRRGIFPEGFVEL 201
+I ++ +P W++GE+ G+ G+FP +V+L
Sbjct: 1180 QIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211
Score = 51.6 bits (122), Expect = 6e-06
Identities = 42/170 (24%), Positives = 71/170 (41%), Gaps = 28/170 (16%)
Query: 1424 PSNSESSPSRCPSDPDSTSQPRSG---DSADVARDVKQPTATPRSYRNF---------RH 1471
P N +P + +D S P+ A +A +P+ TP ++ +F
Sbjct: 805 PENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEK 864
Query: 1472 PEIVGY---------SVPGRNGQSQDLVKGCARTAQAPEDRSTEPDGSEAEGNQVYFAVY 1522
PE + +VP GQ + TA G + EG Q A+Y
Sbjct: 865 PETDNWDAWAAQPSLTVPSA-GQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQ-ALY 922
Query: 1523 TFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIR 1572
++A+ N L+ + N + +LE +D+ WW EV G+KG+ P +Y++
Sbjct: 923 PWRAKKDNHLNFNKNDVITVLEQQDM-----WWFGEVQGQKGWFPKSYVK 967
Score = 47.0 bits (110), Expect = 1e-04
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 10/110 (9%)
Query: 226 VDTPVGEEEIGP---DEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILA-------T 275
V P E GP E Y ALY F++ +E+ + GD + + T
Sbjct: 720 VQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQT 779
Query: 276 LEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPETSL 325
E GWL G LKG+TG FP + + P+ V + + + A P+ +L
Sbjct: 780 GEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLAL 829
Score = 45.4 bits (106), Expect = 4e-04
Identities = 20/54 (37%), Positives = 33/54 (61%), Gaps = 4/54 (7%)
Query: 1521 VYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRKT 1574
+Y + A+N +EL+ + Q + +L +D +WW EVNG+ G PSNY++ T
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKED----PDWWKGEVNGQVGLFPSNYVKLT 1212
Score = 35.8 bits (81), Expect = 0.34
Identities = 18/70 (25%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 1503 RSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGK 1562
R P + + A+YT+++ +L+ + + + KD +WW V K
Sbjct: 992 RVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTK-KD----GDWWTGTVGDK 1046
Query: 1563 KGYVPSNYIR 1572
G PSNY+R
Sbjct: 1047 AGVFPSNYVR 1056
Score = 35.4 bits (80), Expect = 0.44
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 3/59 (5%)
Query: 1518 YFAVYTFKARNPNELSVSANQKLKIL-EFKDV--TGNTEWWLAEVNGKKGYVPSNYIRK 1573
Y A+Y F++R+ +E+++ + + E+ D TG W E+ GK G+ P+NY K
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 90.1 bits (222), Expect = 2e-17
Identities = 95/350 (27%), Positives = 152/350 (43%), Gaps = 53/350 (15%)
Query: 8 RAIFDFCPSVSEELPLFVGDIIEVLAV-VDEF------WLLGKKEDVTGQFPSSFVEIVT 60
RA++ F +E+ + GDI+ V VDE WL G+ + TG FP+++ E
Sbjct: 746 RALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAE--K 803
Query: 61 IPSLKEGERLFVCICEFTSQELDNLPLHR--GDLVILDGIPTA---GWLQGRSC------ 109
IP E + + TS L L L + P+ W S
Sbjct: 804 IPE-NEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTN 862
Query: 110 -------WGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQL-- 160
W A PS V Q + +A P +GQ + GL AQ
Sbjct: 863 EKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQALY 922
Query: 161 ------DEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELL-GPLRTVDESVS 213
D L+F + DVIT++ + WF GE++G++G FP+ +V+L+ GP+R S+
Sbjct: 923 PWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPIRK-STSMD 980
Query: 214 SGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRIL 273
SG+ + V +P + + +E +A+Y +++ E +L F+ GD IL
Sbjct: 981 SGSSESPASLKRVASPAAKPVVSGEE--------FIAMYTYESSEQGDLTFQQGDV--IL 1030
Query: 274 ATLEDG-WLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPE 322
T +DG W G++ + G+FP +V+L E + + GSL + PE
Sbjct: 1031 VTKKDGDWWTGTVGDKAGVFPSNYVRLKDS---EGSGTAGKTGSLGKKPE 1077
Score = 77.8 bits (190), Expect = 8e-14
Identities = 85/335 (25%), Positives = 132/335 (39%), Gaps = 71/335 (21%)
Query: 4 GSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIP- 62
G +A++ + L D+I VL D +W G+ + G FP S+V++++ P
Sbjct: 915 GLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWF-GEVQGQKGWFPKSYVKLISGPI 973
Query: 63 ---------------SLKE-----------GERLFVCICEFTSQELDNLPLHRGDLVILD 96
SLK GE F+ + + S E +L +GD++++
Sbjct: 974 RKSTSMDSGSSESPASLKRVASPAAKPVVSGEE-FIAMYTYESSEQGDLTFQQGDVILVT 1032
Query: 97 GIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGL 156
W G + G FPS+ VR L S S +L + PE A+ +
Sbjct: 1033 K-KDGDWWTG-TVGDKAGVFPSNYVR-LKDSEGSGTAGKTGSLGKKPEI----AQVIASY 1085
Query: 157 SAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR-----GIFPEGFVELLGPLRTVDES 211
+A E+L G +I I GW+EGEL+ R G FP +V+LL P
Sbjct: 1086 TATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP------- 1138
Query: 212 VSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVA----LYRFQALEPNELDFEVG 267
G +I P E + V +Y + A +EL F G
Sbjct: 1139 -------------------GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKG 1179
Query: 268 DKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPD 302
I +L + W +G + G+ G+FP +VKL D
Sbjct: 1180 QIINVLNKEDPDWWKGEVNGQVGLFPSNYVKLTTD 1214
Score = 75.5 bits (184), Expect = 4e-13
Identities = 56/200 (28%), Positives = 98/200 (49%), Gaps = 19/200 (9%)
Query: 784 KRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQV-PNIDFEGLFGNMQMVIKVSKQLL 842
KR I EL+ TE +Y+ DL++ E P+ ++++ + +F N + +I + +LL
Sbjct: 1237 KRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLL 1296
Query: 843 AALEISDA----------VGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKH 892
AL + +G + ++ Y +C AL++ + DE
Sbjct: 1297 KALRVRKKMSGEKMPVKMIGDILSAQLPHMQ-PYIRFCSRQLNGAALIQ-QKTDEA---- 1350
Query: 893 LQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTN 952
D +K L + C + L SF++KP+QRV RYPL++ +L +TPE+HPD L +
Sbjct: 1351 -PDFKEFVKRLAMDPRCKG-MPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSHLKH 1408
Query: 953 AVLAVKEINVNINEYKRRKD 972
A+ +E+ +NE R K+
Sbjct: 1409 ALEKAEELCSQVNEGVREKE 1428
Score = 68.2 bits (165), Expect = 6e-11
Identities = 54/212 (25%), Positives = 96/212 (45%), Gaps = 16/212 (7%)
Query: 3 AGSVVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIP 62
+G A++ + S +L GD+I ++ D W G D G FPS++V +
Sbjct: 1003 SGEEFIAMYTYESSEQGDLTFQQGDVI-LVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSE 1061
Query: 63 ---------SLKEGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGW----LQGRSC 109
SL + + I +T+ + L L G L+++ GW LQ R
Sbjct: 1062 GSGTAGKTGSLGKKPEIAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGK 1121
Query: 110 WGARGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREG 169
G+FP++ V+ LS + + ++ Q + +AQ D+EL F +G
Sbjct: 1122 KRQIGWFPANYVK--LLSPGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKG 1179
Query: 170 DVITIIGVPEPGWFEGELEGRRGIFPEGFVEL 201
+I ++ +P W++GE+ G+ G+FP +V+L
Sbjct: 1180 QIINVLNKEDPDWWKGEVNGQVGLFPSNYVKL 1211
Score = 51.6 bits (122), Expect = 6e-06
Identities = 42/170 (24%), Positives = 71/170 (41%), Gaps = 28/170 (16%)
Query: 1424 PSNSESSPSRCPSDPDSTSQPRSG---DSADVARDVKQPTATPRSYRNF---------RH 1471
P N +P + +D S P+ A +A +P+ TP ++ +F
Sbjct: 805 PENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTSSEPSTTPNNWADFSSTWPTSTNEK 864
Query: 1472 PEIVGY---------SVPGRNGQSQDLVKGCARTAQAPEDRSTEPDGSEAEGNQVYFAVY 1522
PE + +VP GQ + TA G + EG Q A+Y
Sbjct: 865 PETDNWDAWAAQPSLTVPSA-GQLRQRSAFTPATATGSSPSPVLGQGEKVEGLQAQ-ALY 922
Query: 1523 TFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIR 1572
++A+ N L+ + N + +LE +D+ WW EV G+KG+ P +Y++
Sbjct: 923 PWRAKKDNHLNFNKNDVITVLEQQDM-----WWFGEVQGQKGWFPKSYVK 967
Score = 47.0 bits (110), Expect = 1e-04
Identities = 32/110 (29%), Positives = 48/110 (43%), Gaps = 10/110 (9%)
Query: 226 VDTPVGEEEIGP---DEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILA-------T 275
V P E GP E Y ALY F++ +E+ + GD + + T
Sbjct: 720 VQAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQT 779
Query: 276 LEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPETSL 325
E GWL G LKG+TG FP + + P+ V + + + A P+ +L
Sbjct: 780 GEPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLAL 829
Score = 45.4 bits (106), Expect = 4e-04
Identities = 20/54 (37%), Positives = 33/54 (61%), Gaps = 4/54 (7%)
Query: 1521 VYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRKT 1574
+Y + A+N +EL+ + Q + +L +D +WW EVNG+ G PSNY++ T
Sbjct: 1163 MYDYTAQNDDELAFNKGQIINVLNKED----PDWWKGEVNGQVGLFPSNYVKLT 1212
Score = 35.8 bits (81), Expect = 0.34
Identities = 18/70 (25%), Positives = 31/70 (44%), Gaps = 5/70 (7%)
Query: 1503 RSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGK 1562
R P + + A+YT+++ +L+ + + + KD +WW V K
Sbjct: 992 RVASPAAKPVVSGEEFIAMYTYESSEQGDLTFQQGDVILVTK-KD----GDWWTGTVGDK 1046
Query: 1563 KGYVPSNYIR 1572
G PSNY+R
Sbjct: 1047 AGVFPSNYVR 1056
Score = 35.4 bits (80), Expect = 0.44
Identities = 19/59 (32%), Positives = 33/59 (55%), Gaps = 3/59 (5%)
Query: 1518 YFAVYTFKARNPNELSVSANQKLKIL-EFKDV--TGNTEWWLAEVNGKKGYVPSNYIRK 1573
Y A+Y F++R+ +E+++ + + E+ D TG W E+ GK G+ P+NY K
Sbjct: 745 YRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTGEPGWLGGELKGKTGWFPANYAEK 803
Score = 35.4 bits (80), Expect = 0.44
Identities = 33/154 (21%), Positives = 64/154 (41%), Gaps = 18/154 (11%)
Query: 6 VVRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGK-----KEDVTGQFPSSFVEIVT 60
+ + I + + E+L L G +I + W G+ K+ G FP+++V++++
Sbjct: 1078 IAQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLS 1137
Query: 61 ------IPSLKEGERLFVCICE------FTSQELDNLPLHRGDLVILDGIPTAGWLQGRS 108
P+ +C+ +T+Q D L ++G ++ + W +G
Sbjct: 1138 PGTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEV 1197
Query: 109 CWGARGFFPSSCVRELCLSSQSRQWHSQSALFQI 142
G G FPS+ V+ S+QW S L +
Sbjct: 1198 N-GQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDM 1230
>gi|58331187 T-cell lymphoma invasion and metastasis 2 isoform a [Homo
sapiens]
Length = 1701
Score = 86.3 bits (212), Expect = 2e-16
Identities = 79/301 (26%), Positives = 138/301 (45%), Gaps = 48/301 (15%)
Query: 740 SNIESLNMELQQLREMTLL--SSQSSSLVAPSGSVSAENPEQRML-------EKRAKVIE 790
S+ E + + ++T L S S G ++P R L ++ KVI+
Sbjct: 1046 SHREKMEQTFRSAEQITALCRSFNDSQANGMEGPRENQDPPPRPLARHLSDADRLRKVIQ 1105
Query: 791 ELLQTERDYIRDLEMCIERIMVPMQ-QAQVPNIDFEGLFGNMQMVIKVSKQLLAALE--- 846
EL+ TE+ Y++DL E + P+Q + + + E LFG++ +++ K L LE
Sbjct: 1106 ELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVFLETLEDGI 1165
Query: 847 -----------------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKI 889
+ ++G FL + D + Y +C NH + +LE + D+
Sbjct: 1166 SASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLERAKTDKAF 1224
Query: 890 QKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVP 949
+ L D ++ + T L S+LIKPVQRV++YPLLL EL++ T + +
Sbjct: 1225 KAFL-----DARNPTKQHSST----LESYLIKPVQRVLKYPLLLKELVSLTDQESEEHYH 1275
Query: 950 LTNAVLAVKEINVNINE-------YKRRKDLVLKYRKGDEDSLME-KISKLNIHSIIKKS 1001
LT A+ A++++ +INE Y D ++ + G E + E + +L +HS +
Sbjct: 1276 LTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELLMHSTVSWL 1335
Query: 1002 N 1002
N
Sbjct: 1336 N 1336
>gi|58331189 T-cell lymphoma invasion and metastasis 2 isoform b [Homo
sapiens]
Length = 626
Score = 85.1 bits (209), Expect = 5e-16
Identities = 69/249 (27%), Positives = 121/249 (48%), Gaps = 39/249 (15%)
Query: 783 EKRAKVIEELLQTERDYIRDLEMCIERIMVPMQ-QAQVPNIDFEGLFGNMQMVIKVSKQL 841
++ KVI+EL+ TE+ Y++DL E + P+Q + + + E LFG++ +++ K
Sbjct: 23 DRLRKVIQELVDTEKSYVKDLSCLFELYLEPLQNETFLTQDEMESLFGSLPEMLEFQKVF 82
Query: 842 LAALE--------------------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLE 881
L LE + ++G FL + D + Y +C NH + +LE
Sbjct: 83 LETLEDGISASSDFNTLETPSQFRKLLFSLGGSFLYYADHFK-LYSGFCANHIKVQKVLE 141
Query: 882 IYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTP 941
+ D+ + L D ++ + T L S+LIKPVQRV++YPLLL EL++ T
Sbjct: 142 RAKTDKAFKAFL-----DARNPTKQHSST----LESYLIKPVQRVLKYPLLLKELVSLTD 192
Query: 942 ESHPDKVPLTNAVLAVKEINVNINE-------YKRRKDLVLKYRKGDEDSLME-KISKLN 993
+ + LT A+ A++++ +INE Y D ++ + G E + E + +L
Sbjct: 193 QESEEHYHLTEALKAMEKVASHINEMQKIYEDYGTVFDQLVAEQSGTEKEVTELSMGELL 252
Query: 994 IHSIIKKSN 1002
+HS + N
Sbjct: 253 MHSTVSWLN 261
>gi|13994242 SH3-domain kinase binding protein 1 isoform a [Homo
sapiens]
Length = 665
Score = 84.7 bits (208), Expect = 6e-16
Identities = 57/214 (26%), Positives = 96/214 (44%), Gaps = 29/214 (13%)
Query: 158 AQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQ 217
AQ D+EL G++IT I + GW+EG++ GRRG+FP+ FV + +
Sbjct: 12 AQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFV----------REIKKEMK 61
Query: 218 DDCIVNGEVDTPVGEEEIG-----------PDEDEEEPGTYGVALYRFQALEPNELDFEV 266
D + N + P+ E G ++ E + + +EL+ +V
Sbjct: 62 KDPLTNKAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKV 121
Query: 267 GDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSLARIPETSLD 326
GD I ++ +E+GW EG L G+TG+FP F+K E E +++ + S
Sbjct: 122 GDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIK--------ELSGESDELGISQDEQLSKS 173
Query: 327 CLENTLGVEEQRHETSDHEAEEPDCIISEAPTSP 360
L T G E ++S ++E + ++ A P
Sbjct: 174 SLRETTGSESDGGDSSSTKSEGANGTVATAAIQP 207
Score = 80.1 bits (196), Expect = 2e-14
Identities = 85/372 (22%), Positives = 140/372 (37%), Gaps = 103/372 (27%)
Query: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
++ +Q D L + G+++ GW +G+ G RG FP + VRE+ + +
Sbjct: 9 DYQAQHDDELTISVGEIITNIRKEDGGWWEGQIN-GRRGLFPDNFVREIKKEMKKDPLTN 67
Query: 136 QSA---LFQIP------------------EYSMGQARALMGLSAQLDEELDFREGDVITI 174
++ L ++P E + + Q D+EL+ + GD+I +
Sbjct: 68 KAPEKPLHEVPSGNSLLSSETILRTNKRGERRRRRCQVAFSYLPQNDDELELKVGDIIEV 127
Query: 175 IGVPEPGWFEGELEGRRGIFPEGFVELLG-----------------PLRTVDESVSSGNQ 217
+G E GW+EG L G+ G+FP F++ L LR S S G
Sbjct: 128 VGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQDEQLSKSSLRETTGSESDGGD 187
Query: 218 DDCI----VNGEV--------------------DTPVG---------------EEEIG-- 236
NG V D P+ E+ IG
Sbjct: 188 SSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKLRPRSIEVENDFLPVEKTIGKK 247
Query: 237 -------PDEDEEEPGT------YGVALYRFQALEPNELDFEVGDKIRILAT--LEDGWL 281
PD + E + Y ++ ++A +EL + GD + ++ ++ GW
Sbjct: 248 LPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWW 307
Query: 282 EGSLKGRTGIFPYRFVKLCPDTRVEETMALPQEGSL-ARIPETSLDCLENTLGVEEQRHE 340
EG L GR G+FP FVKL P +EG+ + P S ++ G E++HE
Sbjct: 308 EGELNGRRGVFPDNFVKLLPPD-------FEKEGNRPKKPPPPSAPVIKQGAGTTERKHE 360
Query: 341 TSDHEAEEPDCI 352
E P+ +
Sbjct: 361 IKKIPPERPEML 372
Score = 79.0 bits (193), Expect = 3e-14
Identities = 64/222 (28%), Positives = 94/222 (42%), Gaps = 28/222 (12%)
Query: 11 FDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPS----LKE 66
F + P +EL L VGDIIEV+ V+E W G TG FPS+F++ ++ S + +
Sbjct: 107 FSYLPQNDDELELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKELSGESDELGISQ 166
Query: 67 GERLFVC-ICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGA------------- 112
E+L + E T E D +G +Q + G
Sbjct: 167 DEQLSKSSLRETTGSESDGGDSSSTKSEGANGTVATAAIQPKKVKGVGFGDIFKDKPIKL 226
Query: 113 --------RGFFPSSCVRELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEEL 164
F P L + + S S + + AQ D+EL
Sbjct: 227 RPRSIEVENDFLPVEKTIGKKLPATTATPDSSKTEMDSRTKSKDYCKVIFPYEAQNDDEL 286
Query: 165 DFREGDVITIIGVP--EPGWFEGELEGRRGIFPEGFVELLGP 204
+EGD++T+I + GW+EGEL GRRG+FP+ FV+LL P
Sbjct: 287 TIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPP 328
Score = 41.6 bits (96), Expect = 0.006
Identities = 20/77 (25%), Positives = 40/77 (51%), Gaps = 3/77 (3%)
Query: 1496 TAQAPEDRSTEPDGSEAEGNQVYFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWW 1555
T P+ TE D S + ++ ++A+N +EL++ + ++ KD + WW
Sbjct: 251 TTATPDSSKTEMD-SRTKSKDYCKVIFPYEAQNDDELTIKEGDIVTLIN-KDCI-DVGWW 307
Query: 1556 LAEVNGKKGYVPSNYIR 1572
E+NG++G P N+++
Sbjct: 308 EGELNGRRGVFPDNFVK 324
Score = 40.8 bits (94), Expect = 0.010
Identities = 18/47 (38%), Positives = 27/47 (57%)
Query: 252 YRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVK 298
+ +QA +EL VG+ I + + GW EG + GR G+FP FV+
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVR 54
Score = 36.2 bits (82), Expect = 0.26
Identities = 13/52 (25%), Positives = 32/52 (61%), Gaps = 4/52 (7%)
Query: 1522 YTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRK 1573
+ ++A++ +EL++S + + + +D WW ++NG++G P N++R+
Sbjct: 8 FDYQAQHDDELTISVGEIITNIRKED----GGWWEGQINGRRGLFPDNFVRE 55
Score = 35.4 bits (80), Expect = 0.44
Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 8/54 (14%)
Query: 1522 YTFKARNPNELSVSANQKLKILEFKDVTGNTE--WWLAEVNGKKGYVPSNYIRK 1573
+++ +N +EL +LK+ + +V G E WW +NGK G PSN+I++
Sbjct: 107 FSYLPQNDDEL------ELKVGDIIEVVGEVEEGWWEGVLNGKTGMFPSNFIKE 154
Score = 32.0 bits (71), Expect = 4.9
Identities = 19/64 (29%), Positives = 32/64 (50%), Gaps = 2/64 (3%)
Query: 8 RAIFDFCPSVSEELPLFVGDIIEVLA--VVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 65
+ IF + +EL + GDI+ ++ +D W G+ G FP +FV+++ K
Sbjct: 273 KVIFPYEAQNDDELTIKEGDIVTLINKDCIDVGWWEGELNGRRGVFPDNFVKLLPPDFEK 332
Query: 66 EGER 69
EG R
Sbjct: 333 EGNR 336
>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
Length = 516
Score = 83.6 bits (205), Expect = 1e-15
Identities = 65/226 (28%), Positives = 105/226 (46%), Gaps = 19/226 (8%)
Query: 761 QSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVP 820
Q+ L S + P Q + RA VI E++ TER YI+ L+ E + ++ +
Sbjct: 80 QNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEGYLKQCRKRRDM 139
Query: 821 NID--FEGLFGNMQMVIKVSKQLLAALEIS--------DAVGPVFLGHRDELEGTYKIYC 870
D + +FGN++ + + + LE +GP FL H+D Y YC
Sbjct: 140 FSDEQLKVIFGNIEDIYRFQMGFVRDLEKQYNNDDPHLSEIGPCFLEHQDGF-WIYSEYC 198
Query: 871 QNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYP 930
NH +A L KD + Q H ++ L+ + + I + FL+ PVQ++ +YP
Sbjct: 199 NNHLDACMELSKLMKDSRYQ-HFFEACRLLQQMID-------IAIDGFLLTPVQKICKYP 250
Query: 931 LLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKDLVLK 976
L L ELL T + H D + A+ ++ + INE KRR + + K
Sbjct: 251 LQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDK 296
Score = 39.7 bits (91), Expect = 0.023
Identities = 24/82 (29%), Positives = 38/82 (46%), Gaps = 5/82 (6%)
Query: 146 SMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPL 205
S+ A A+ + EL F+ GDVI ++ W+ G+++ G FP FV L
Sbjct: 9 SIVSAEAVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRL---W 65
Query: 206 RTVDESVSSGNQDDCIVNGEVD 227
++ V G D + NG +D
Sbjct: 66 VNQEDEVEEGPSD--VQNGHLD 85
Score = 38.9 bits (89), Expect = 0.040
Identities = 18/50 (36%), Positives = 29/50 (58%)
Query: 9 AIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEI 58
A++D + EL GD+I+VL ++ W G+ +D G FP+SFV +
Sbjct: 15 AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRL 64
Score = 35.4 bits (80), Expect = 0.44
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 6/81 (7%)
Query: 250 ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKLC--PDTRVEE 307
A++ + EL F+ GD I++L W G + G FP FV+L + VEE
Sbjct: 15 AVWDHVTMANRELAFKAGDVIKVLDASNKDWWWGQIDDEEGWFPASFVRLWVNQEDEVEE 74
Query: 308 TMALPQEGSLARIPETSLDCL 328
+ Q G L + + DCL
Sbjct: 75 GPSDVQNGHL----DPNSDCL 91
Score = 33.1 bits (74), Expect = 2.2
Identities = 13/53 (24%), Positives = 29/53 (54%), Gaps = 4/53 (7%)
Query: 1520 AVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIR 1572
AV+ EL+ A +K+L+ N +WW +++ ++G+ P++++R
Sbjct: 15 AVWDHVTMANRELAFKAGDVIKVLD----ASNKDWWWGQIDDEEGWFPASFVR 63
>gi|78000171 sorbin and SH3 domain containing 1 isoform 7 [Homo
sapiens]
Length = 740
Score = 80.5 bits (197), Expect = 1e-14
Identities = 62/234 (26%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
+F +Q L LPL +GD+V + W +G G G FP + + EL ++ Q
Sbjct: 509 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH-HGRVGIFPRTYI-ELLPPAEKAQPKK 566
Query: 136 QSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG--RRGI 193
+ + Q+ EY G+A A + E+ FR+G+ IT++ + W+EG + G R+GI
Sbjct: 567 LTPV-QVLEY--GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 623
Query: 194 FPEGFVELL------GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTY 247
FP +V+++ P+ +D SS + + + + PD + +
Sbjct: 624 FPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ-QPQAQQRRVTPDRSQTSQDLF 682
Query: 248 GV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
ALY + +EL+ GD + ++ +DGW G+ + + G FP +VK
Sbjct: 683 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 736
Score = 70.5 bits (171), Expect = 1e-11
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 501 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 560
Query: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
TPV E G +A + F E+ F
Sbjct: 561 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 596
Query: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 597 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 654
Score = 58.9 bits (141), Expect = 4e-08
Identities = 55/234 (23%), Positives = 93/234 (39%), Gaps = 39/234 (16%)
Query: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 505 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 564
Query: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
++L + F + +G+ + L W +GR +R G F
Sbjct: 565 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 624
Query: 117 P------------SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQA-------------- 150
P + V + L S S +A Q P+ +
Sbjct: 625 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY 684
Query: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 685 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 738
>gi|78000169 sorbin and SH3 domain containing 1 isoform 6 [Homo
sapiens]
Length = 781
Score = 80.5 bits (197), Expect = 1e-14
Identities = 62/234 (26%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
+F +Q L LPL +GD+V + W +G G G FP + + EL ++ Q
Sbjct: 550 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH-HGRVGIFPRTYI-ELLPPAEKAQPKK 607
Query: 136 QSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG--RRGI 193
+ + Q+ EY G+A A + E+ FR+G+ IT++ + W+EG + G R+GI
Sbjct: 608 LTPV-QVLEY--GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 664
Query: 194 FPEGFVELL------GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTY 247
FP +V+++ P+ +D SS + + + + PD + +
Sbjct: 665 FPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ-QPQAQQRRVTPDRSQTSQDLF 723
Query: 248 GV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
ALY + +EL+ GD + ++ +DGW G+ + + G FP +VK
Sbjct: 724 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 777
Score = 70.5 bits (171), Expect = 1e-11
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 542 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 601
Query: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
TPV E G +A + F E+ F
Sbjct: 602 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 637
Query: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 638 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 695
Score = 58.9 bits (141), Expect = 4e-08
Identities = 55/234 (23%), Positives = 93/234 (39%), Gaps = 39/234 (16%)
Query: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 546 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 605
Query: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
++L + F + +G+ + L W +GR +R G F
Sbjct: 606 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 665
Query: 117 P------------SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQA-------------- 150
P + V + L S S +A Q P+ +
Sbjct: 666 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY 725
Query: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 726 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 779
>gi|7661700 sorbin and SH3 domain containing 1 isoform 2 [Homo
sapiens]
Length = 816
Score = 80.5 bits (197), Expect = 1e-14
Identities = 62/234 (26%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
+F +Q L LPL +GD+V + W +G G G FP + + EL ++ Q
Sbjct: 585 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH-HGRVGIFPRTYI-ELLPPAEKAQPKK 642
Query: 136 QSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG--RRGI 193
+ + Q+ EY G+A A + E+ FR+G+ IT++ + W+EG + G R+GI
Sbjct: 643 LTPV-QVLEY--GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 699
Query: 194 FPEGFVELL------GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTY 247
FP +V+++ P+ +D SS + + + + PD + +
Sbjct: 700 FPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ-QPQAQQRRVTPDRSQTSQDLF 758
Query: 248 GV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
ALY + +EL+ GD + ++ +DGW G+ + + G FP +VK
Sbjct: 759 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 812
Score = 70.5 bits (171), Expect = 1e-11
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 577 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 636
Query: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
TPV E G +A + F E+ F
Sbjct: 637 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 672
Query: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 673 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 730
Score = 58.9 bits (141), Expect = 4e-08
Identities = 55/234 (23%), Positives = 93/234 (39%), Gaps = 39/234 (16%)
Query: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 581 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 640
Query: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
++L + F + +G+ + L W +GR +R G F
Sbjct: 641 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 700
Query: 117 P------------SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQA-------------- 150
P + V + L S S +A Q P+ +
Sbjct: 701 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY 760
Query: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 761 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 814
>gi|78000160 sorbin and SH3 domain containing 1 isoform 1 [Homo
sapiens]
Length = 684
Score = 80.5 bits (197), Expect = 1e-14
Identities = 62/234 (26%), Positives = 109/234 (46%), Gaps = 17/234 (7%)
Query: 76 EFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELCLSSQSRQWHS 135
+F +Q L LPL +GD+V + W +G G G FP + + EL ++ Q
Sbjct: 453 DFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEH-HGRVGIFPRTYI-ELLPPAEKAQPKK 510
Query: 136 QSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEG--RRGI 193
+ + Q+ EY G+A A + E+ FR+G+ IT++ + W+EG + G R+GI
Sbjct: 511 LTPV-QVLEY--GEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGI 567
Query: 194 FPEGFVELL------GPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTY 247
FP +V+++ P+ +D SS + + + + PD + +
Sbjct: 568 FPITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQ-QPQAQQRRVTPDRSQTSQDLF 626
Query: 248 GV-ALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLK--GRTGIFPYRFVK 298
ALY + +EL+ GD + ++ +DGW G+ + + G FP +VK
Sbjct: 627 SYQALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVK 680
Score = 70.5 bits (171), Expect = 1e-11
Identities = 53/178 (29%), Positives = 77/178 (43%), Gaps = 29/178 (16%)
Query: 147 MGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLR 206
M ARA AQ +EL ++GD++ I + W+EGE GR GIFP ++ELL P
Sbjct: 445 MRPARAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAE 504
Query: 207 TVDESVSSGNQDDCIVNGEVDTPVGEEEIGPDEDEEEPGTYGVALYRFQALEPNELDFEV 266
TPV E G +A + F E+ F
Sbjct: 505 KAQPKKL--------------TPVQVLEYGE----------AIAKFNFNGDTQVEMSFRK 540
Query: 267 GDKIRILATLEDGWLEGSLKG--RTGIFPYRFVKLCPDTRVE---ETMALPQEGSLAR 319
G++I +L +++ W EG + G R GIFP +V + V+ + M LP S +R
Sbjct: 541 GERITLLRQVDENWYEGRIPGTSRQGIFPITYVDVIKRPLVKNPVDYMDLPFSSSPSR 598
Score = 58.9 bits (141), Expect = 4e-08
Identities = 55/234 (23%), Positives = 93/234 (39%), Gaps = 39/234 (16%)
Query: 8 RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEG 67
RA FDF +ELPL GDI+ + +D+ W G+ G FP +++E++ +
Sbjct: 449 RAKFDFKAQTLKELPLQKGDIVYIYKQIDQNWYEGEHHGRVGIFPRTYIELLPPAEKAQP 508
Query: 68 ERL----------FVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGAR-GFF 116
++L + F + +G+ + L W +GR +R G F
Sbjct: 509 KKLTPVQVLEYGEAIAKFNFNGDTQVEMSFRKGERITLLRQVDENWYEGRIPGTSRQGIF 568
Query: 117 P------------SSCVRELCLSSQSRQWHSQSALFQIPEYSMGQA-------------- 150
P + V + L S S +A Q P+ +
Sbjct: 569 PITYVDVIKRPLVKNPVDYMDLPFSSSPSRSATASPQQPQAQQRRVTPDRSQTSQDLFSY 628
Query: 151 RALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRR--GIFPEGFVELL 202
+AL Q D+EL+ R+GD++ ++ + GWF G + G FP +V+ L
Sbjct: 629 QALYSYIPQNDDELELRDGDIVDVMEKCDDGWFVGTSRRTKQFGTFPGNYVKPL 682
>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
[Homo sapiens]
Length = 690
Score = 80.5 bits (197), Expect = 1e-14
Identities = 68/230 (29%), Positives = 111/230 (48%), Gaps = 25/230 (10%)
Query: 767 APSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDL-EMCIERIMVPMQQAQVPNID-F 824
A G A++ + +M R VI E+L TERDYI+ L ++C + ++A + + +
Sbjct: 270 AEDGGAEAQSSKDQM---RTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQL 326
Query: 825 EGLFGNMQMVIKVSKQLLAALEIS--------DAVGPVFLGHRDELEGTYKIYCQNHDEA 876
+FGN++ + + K + ALE +G FL H+ + + Y YC NH A
Sbjct: 327 RTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNA 385
Query: 877 IALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMEL 936
L K K + ++ L+ + + I+L FL+ PVQ++ +YPL L EL
Sbjct: 386 CVELSRLTKLSKYV-YFFEACRLLQKMID-------ISLDGFLLTPVQKICKYPLQLAEL 437
Query: 937 LNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRK---DLVLKYRKGDED 983
L T H D + A+ A+K + INE KRR D + +++ ED
Sbjct: 438 LKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIED 487
Score = 39.7 bits (91), Expect = 0.023
Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 4 GSVV--RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEI 58
GSVV A++D +EL GD+IEV+ + W G+ D G FP+SFV +
Sbjct: 194 GSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRL 250
Score = 36.6 bits (83), Expect = 0.20
Identities = 21/60 (35%), Positives = 29/60 (48%)
Query: 142 IPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVEL 201
I + S+ A AL D+EL F+ GDVI ++ W+ G + G FP FV L
Sbjct: 191 ISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRL 250
Score = 33.9 bits (76), Expect = 1.3
Identities = 27/105 (25%), Positives = 40/105 (38%), Gaps = 28/105 (26%)
Query: 223 NGEVDTPVGEEEIGPDED-----------EEEPGTYGV-----------------ALYRF 254
+G +DT V +E+G +ED PG G AL+
Sbjct: 146 DGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGGGGEQLAINELISDGSVVCAEALWDH 205
Query: 255 QALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKL 299
++ EL F+ GD I ++ W G + G FP FV+L
Sbjct: 206 VTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRL 250
>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
[Homo sapiens]
Length = 670
Score = 80.5 bits (197), Expect = 1e-14
Identities = 68/230 (29%), Positives = 111/230 (48%), Gaps = 25/230 (10%)
Query: 767 APSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDL-EMCIERIMVPMQQAQVPNID-F 824
A G A++ + +M R VI E+L TERDYI+ L ++C + ++A + + +
Sbjct: 270 AEDGGAEAQSSKDQM---RTNVINEILSTERDYIKHLRDICEGYVRQCRKRADMFSEEQL 326
Query: 825 EGLFGNMQMVIKVSKQLLAALEIS--------DAVGPVFLGHRDELEGTYKIYCQNHDEA 876
+FGN++ + + K + ALE +G FL H+ + + Y YC NH A
Sbjct: 327 RTIFGNIEDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQ-IYSEYCNNHPNA 385
Query: 877 IALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMEL 936
L K K + ++ L+ + + I+L FL+ PVQ++ +YPL L EL
Sbjct: 386 CVELSRLTKLSKYV-YFFEACRLLQKMID-------ISLDGFLLTPVQKICKYPLQLAEL 437
Query: 937 LNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRK---DLVLKYRKGDED 983
L T H D + A+ A+K + INE KRR D + +++ ED
Sbjct: 438 LKYTHPQHRDFKDVEAALHAMKNVAQLINERKRRLENIDKIAQWQSSIED 487
Score = 39.7 bits (91), Expect = 0.023
Identities = 22/57 (38%), Positives = 31/57 (54%), Gaps = 2/57 (3%)
Query: 4 GSVV--RAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEI 58
GSVV A++D +EL GD+IEV+ + W G+ D G FP+SFV +
Sbjct: 194 GSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRL 250
Score = 36.6 bits (83), Expect = 0.20
Identities = 21/60 (35%), Positives = 29/60 (48%)
Query: 142 IPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEPGWFEGELEGRRGIFPEGFVEL 201
I + S+ A AL D+EL F+ GDVI ++ W+ G + G FP FV L
Sbjct: 191 ISDGSVVCAEALWDHVTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRL 250
Score = 33.9 bits (76), Expect = 1.3
Identities = 27/105 (25%), Positives = 40/105 (38%), Gaps = 28/105 (26%)
Query: 223 NGEVDTPVGEEEIGPDED-----------EEEPGTYGV-----------------ALYRF 254
+G +DT V +E+G +ED PG G AL+
Sbjct: 146 DGALDTAVCADEVGSEEDLYDDLHSSSHHYSHPGGGGEQLAINELISDGSVVCAEALWDH 205
Query: 255 QALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYRFVKL 299
++ EL F+ GD I ++ W G + G FP FV+L
Sbjct: 206 VTMDDQELGFKAGDVIEVMDATNREWWWGRVADGEGWFPASFVRL 250
>gi|45439359 triple functional domain (PTPRF interacting) [Homo
sapiens]
Length = 3097
Score = 80.1 bits (196), Expect = 2e-14
Identities = 83/324 (25%), Positives = 142/324 (43%), Gaps = 53/324 (16%)
Query: 668 PTCETLEKEG--PGHMGRSLDQTSPCPLVLVRIEEMERDLDMYS----RAQEELNLMLEE 721
P ET+E+ G G +L ++S + EE E D A ++ +L+ +
Sbjct: 1825 PQDETVEERGRNEGLSSGTLSKSSSSGMQSCGEEEGEEGADAVPLPPPMAIQQHSLLQPD 1884
Query: 722 KQDESSRAETLEDLKFCE--SNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSA----- 774
QD+ + + L E S E ++ + ++ L + SSL+ G S+
Sbjct: 1885 SQDDKASSRLLVRPTSSETPSAAELVSAIEELVKSKMALEDRPSSLLVDQGDSSSPSFNP 1944
Query: 775 ---------------ENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQV 819
E + L++R V++EL++TERDY+RDL +E M M++ V
Sbjct: 1945 SDNSLLSSSSPIDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDGV 2004
Query: 820 PNIDFEG----LFGNMQMVIKVSK-----QLLAALEISDAVGPVFLGHRDELEGTYKIYC 870
P+ D +G +FGN+ + + +L LE + +G +F+ H L Y YC
Sbjct: 2005 PD-DMKGKDKIVFGNIHQIYDWHRDFFLGELEKCLEDPEKLGSLFVKHERRLH-MYIAYC 2062
Query: 871 QNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYP 930
QN ++ + + +++ DLK + + L LIKPVQR+M+Y
Sbjct: 2063 QNKPKS---------EHIVSEYIDTFFEDLKQRLG-----HRLQLTDLLIKPVQRIMKYQ 2108
Query: 931 LLLMELLNSTPESHPDKVPLTNAV 954
LLL + L + ++ D L AV
Sbjct: 2109 LLLKDFLKYSKKASLDTSELERAV 2132
Score = 63.9 bits (154), Expect = 1e-09
Identities = 54/178 (30%), Positives = 87/178 (48%), Gaps = 26/178 (14%)
Query: 776 NPEQRMLEKRAK-VIEELLQTERDYIRDLEMCIERIMVPMQQAQV---PNIDFEGL--FG 829
N E+R +R + ++ EL+QTE+ Y+RDL C++ + M P I + L FG
Sbjct: 1283 NEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEEIPPGIVNKELIIFG 1342
Query: 830 NMQMVIKVS-----KQLLAALEISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYE 884
NMQ + + K+L ++ + VG F+ D+ + Y YC+N ++ L+
Sbjct: 1343 NMQEIYEFHNNIFLKELEKYEQLPEDVGHCFVTWADKFQ-MYVTYCKNKPDSTQLI---- 1397
Query: 885 KDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPE 942
L+ + + + G N I+ S+LIKPVQR+ +Y LLL ELL E
Sbjct: 1398 --------LEHAGSYFDEIQQRHGLANSIS--SYLIKPVQRITKYQLLLKELLTCCEE 1445
Score = 33.1 bits (74), Expect = 2.2
Identities = 48/224 (21%), Positives = 89/224 (39%), Gaps = 42/224 (18%)
Query: 702 ERDLDMYSRAQEELNLMLEEKQDESSRAETLEDLKFCESNIESLNMELQQLREMTLL--- 758
+RD+DM +R Q+ L + E++Q+ AE + K E ++ +++ + + + +
Sbjct: 869 DRDVDMATRVQDLLEFLHEKQQELDLAAE--QHRKHLEQCVQLRHLQAEVKQVLGWIRNG 926
Query: 759 -SSQSSSLVAPSGSVSAENPEQR----------------MLEKRAKVIEELLQTERDYIR 801
S ++ L+ S AE ++ ++++A+ + + + D IR
Sbjct: 927 ESMLNAGLITASSLQEAEQLQREHEQFQHAIEKTHQSALQVQQKAEAMLQANHYDMDMIR 986
Query: 802 DLEMCIERIMVPMQQAQVPNIDFEGLFGNMQMVIKVSKQLLAALEISDAVGPVFLGHRDE 861
D C E++ QQ + D L K S+Q+ + LE
Sbjct: 987 D---CAEKVASHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLE--------------S 1029
Query: 862 LEGTYK---IYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKS 902
LE YK +C D+ E I KHL+ A LK+
Sbjct: 1030 LEQEYKREEDWCGGADKLGPNSETDHVTPMISKHLEQKEAFLKA 1073
>gi|115583670 T-cell lymphoma invasion and metastasis 1 [Homo sapiens]
Length = 1591
Score = 79.7 bits (195), Expect = 2e-14
Identities = 70/269 (26%), Positives = 121/269 (44%), Gaps = 32/269 (11%)
Query: 722 KQDESSRAETLEDLKFCESNIESLNMELQQLREMTLLSSQSSSLVAPSGSVSAENPEQRM 781
++ E E+ ++ + E + + L EM S QS S +G A +
Sbjct: 979 EETEGPDLESSDETDHSSKSTEQVAAFCRSLHEMNP-SDQSPSPQDSTGPQLATMRQLSD 1037
Query: 782 LEKRAKVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNID-FEGLFGNMQMVIKVSKQ 840
+K KVI ELL+TER Y++DL +ER + P+Q+ D + LFGN+ +++ +
Sbjct: 1038 ADKLRKVICELLETERTYVKDLNCLMERYLKPLQKETFLTQDELDVLFGNLTEMVEFQVE 1097
Query: 841 LLAALE--------------------ISDAVGPVFLGHRDELEGTYKIYCQNHDEAIALL 880
L LE + ++G FL + D + Y +C +H + +L
Sbjct: 1098 FLKTLEDGVRLVPDLEKLEKVDQFKKVLFSLGGSFLYYADRFK-LYSAFCASHTKVPKVL 1156
Query: 881 EIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNST 940
+ D + L D ++ + T L S+LIKP+QR+++YPLLL EL T
Sbjct: 1157 VKAKTDTAFKAFL-----DAQNPKQQHSST----LESYLIKPIQRILKYPLLLRELFALT 1207
Query: 941 PESHPDKVPLTNAVLAVKEINVNINEYKR 969
+ L A+ + ++ +INE ++
Sbjct: 1208 DAESEEHYHLDVAIKTMNKVASHINEMQK 1236
>gi|71274148 pleckstrin homology domain containing, family G (with
RhoGef domain) member 1 [Homo sapiens]
Length = 1385
Score = 79.7 bits (195), Expect = 2e-14
Identities = 53/200 (26%), Positives = 109/200 (54%), Gaps = 17/200 (8%)
Query: 787 KVIEELLQTERDYIRDLEMCIERIMVPMQ-QAQVP--NIDFEGLFGNMQMVIKVSKQLLA 843
+V++E+L+TER Y++DL+ +E + ++ Q ++P + LFGN+Q + + +LL
Sbjct: 116 RVVQEILETERTYVQDLKSIVEDYLDCIRDQTKLPLGTEERSALFGNIQDIYHFNSELLQ 175
Query: 844 ALEISD----AVGPVFLGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLAD 899
LE + A+ F+ +E Y YC N+ ++A+L +++ + K ++
Sbjct: 176 DLENCENDPVAIAECFVSKSEEFH-IYTQYCTNYPRSVAVLTECMRNKILAKFFRERQET 234
Query: 900 LKSLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKE 959
LK + + LGS+L+KPVQR+++Y LLL E+ N + + +A+ ++
Sbjct: 235 LK---------HSLPLGSYLLKPVQRILKYHLLLHEIENHLDKDTEGYDVVLDAIDTMQR 285
Query: 960 INVNINEYKRRKDLVLKYRK 979
+ +IN+ KR+ + ++ ++
Sbjct: 286 VAWHINDMKRKHEHAVRLQE 305
>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
exchange factor [Homo sapiens]
Length = 1386
Score = 79.3 bits (194), Expect = 3e-14
Identities = 57/193 (29%), Positives = 96/193 (49%), Gaps = 16/193 (8%)
Query: 787 KVIEELLQTERDYIRDLEMCIERIMVPMQQAQVPNIDFEG---LFGNMQMVIKVSKQLLA 843
+V E+++TER Y+RDL +E + P+ V + E LF N++ + + S +LL
Sbjct: 105 RVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLGLSVEQVGTLFANIEDIYEFSSELLE 164
Query: 844 ALEISDAVGPVF--LGHRDELEGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLK 901
LE S + G + R E Y +YC N+ ++ALL LQ+ A L+
Sbjct: 165 DLENSSSAGGIAECFVQRSEDFDIYTLYCMNYPSSLALLRELSLSPPAALWLQERQAQLR 224
Query: 902 SLYNEWGCTNYINLGSFLIKPVQRVMRYPLLLMELLNSTPE--SHPDKVPLTNAVLAVKE 959
+ + L SFL+KPVQR+++Y LLL EL E + + A++++
Sbjct: 225 ---------HSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGTGGREMVEEAIVSMTA 275
Query: 960 INVNINEYKRRKD 972
+ IN+ KR+++
Sbjct: 276 VAWYINDMKRKQE 288
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 77.4 bits (189), Expect = 1e-13
Identities = 65/230 (28%), Positives = 106/230 (46%), Gaps = 22/230 (9%)
Query: 754 EMTLLSSQSSSLVAPSGSVSAENPEQRMLEKRAKVIEELLQTERDYIRDLEMCIERIMVP 813
+MT S S A ++ P +R KR I EL+QTE Y+ DL++ +E
Sbjct: 1155 KMTTDSDPSQQWCADLQTLDTMQPIER---KRQGYIHELIQTEERYMADLQLVVEVFQKR 1211
Query: 814 MQQAQ-VPNIDFEGLFGNMQMVIKVSKQLLAALEIS----------DAVGPVFLGHRDEL 862
M ++ + + +F N + +I + +LL AL + +G + +
Sbjct: 1212 MAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHM 1271
Query: 863 EGTYKIYCQNHDEAIALLEIYEKDEKIQKHLQDSLADLKSLYNEWGCTNYINLGSFLIKP 922
+ Y +C ALL+ ++ K LK L ++ C + L SFL+KP
Sbjct: 1272 QA-YIRFCSCQLNGAALLQQKTDEDTDFKEF------LKKLASDPRCKG-MPLSSFLLKP 1323
Query: 923 VQRVMRYPLLLMELLNSTPESHPDKVPLTNAVLAVKEINVNINEYKRRKD 972
+QR+ RYPLL+ +L +TPESH D L A+ +E+ +NE R K+
Sbjct: 1324 MQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1373
Score = 75.1 bits (183), Expect = 5e-13
Identities = 83/307 (27%), Positives = 135/307 (43%), Gaps = 50/307 (16%)
Query: 8 RAIFDFCPSVSEELPLFVGDIIEV--LAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLK 65
RA++ F +E+ GDII+V V + WL G + G FP ++VE +PS
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE--KMPS-S 792
Query: 66 EGERLFVCICEFTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCVRELC 125
E E+ S + LP V L T+ + + + + L
Sbjct: 793 ENEKA-------VSPKKALLP----PTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT 841
Query: 126 LSSQSRQWHSQSALFQI-------PEYSMGQ------ARALMGLSAQLDEELDFREGDVI 172
+++ W +SA + P + GQ A+AL +A+ D L+F + D+I
Sbjct: 842 VNTS---WQKKSAFTRTVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDII 898
Query: 173 TIIGVPEPGWFEGELEGRRGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGE 232
T++ E WF GE+ G RG FP+ +V+++ G++ + E +
Sbjct: 899 TVLEQQENWWF-GEVHGGRGWFPKSYVKII-----------PGSE---VKREEPEALYAA 943
Query: 233 EEIGPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDG-WLEGSLKGRTGI 291
P G +ALY + ++EP +L F G++ IL T +DG W GS+ R+GI
Sbjct: 944 VNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEE--ILVTQKDGEWWTGSIGDRSGI 1001
Query: 292 FPYRFVK 298
FP +VK
Sbjct: 1002 FPSNYVK 1008
Score = 72.8 bits (177), Expect = 2e-12
Identities = 77/308 (25%), Positives = 122/308 (39%), Gaps = 74/308 (24%)
Query: 27 DIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVTIPSLKEGE------------------ 68
DII VL + +W G+ G FP S+V+I+ +K E
Sbjct: 896 DIITVLEQQENWWF-GEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVNKKPTSAAYS 954
Query: 69 --RLFVCICEFTSQELDNLPLHRGDLVIL---DGIPTAGWLQGRSCWGARGFFPSSCVR- 122
++ + ++S E +L G+ +++ DG G + RS G FPS+ V+
Sbjct: 955 VGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTGSIGDRS-----GIFPSNYVKP 1009
Query: 123 --ELCLSSQSRQWHSQSALFQIPEYSMGQARALMGLSAQLDEELDFREGDVITIIGVPEP 180
+ S S+ S PE A+ A E+L G +I I+
Sbjct: 1010 KDQESFGSASKSGASNKK----PEI----AQVTSAYVASGSEQLSLAPGQLILILKKNTS 1061
Query: 181 GWFEGELEGR-----RGIFPEGFVELLGPLRTVDESVSSGNQDDCIVNGEVDTPVGEEEI 235
GW++GEL+ R +G FP V+LLGP + E TP
Sbjct: 1062 GWWQGELQARGKKRQKGWFPASHVKLLGP------------------SSERATPA----- 1098
Query: 236 GPDEDEEEPGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKGRTGIFPYR 295
P +A+Y + A +EL F G I ++ + W +G + G TG+FP
Sbjct: 1099 ------FHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSN 1152
Query: 296 FVKLCPDT 303
+VK+ D+
Sbjct: 1153 YVKMTTDS 1160
Score = 49.7 bits (117), Expect = 2e-05
Identities = 58/206 (28%), Positives = 80/206 (38%), Gaps = 46/206 (22%)
Query: 151 RALMGLSAQLDEELDFREGDVITIIG--VPEPGWFEGELEGRRGIFPEGFVE-------- 200
RAL A+ +E+ F GD+I + V EPGW G +G G FP +VE
Sbjct: 736 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 795
Query: 201 --------LLGPL------RTVDESVSSGN-------QDDCIVNGEVDTP---------- 229
LL P T E +SS Q+ N V+T
Sbjct: 796 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT 855
Query: 230 VGEEEIGPDEDEEE--PGTYGVALYRFQALEPNELDFEVGDKIRILATLEDGWLEGSLKG 287
V + P + + AL + A + N L+F D I +L E+ W G + G
Sbjct: 856 VSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWF-GEVHG 914
Query: 288 RTGIFPYRFVKLCPDTRV--EETMAL 311
G FP +VK+ P + V EE AL
Sbjct: 915 GRGWFPKSYVKIIPGSEVKREEPEAL 940
Score = 47.0 bits (110), Expect = 1e-04
Identities = 21/55 (38%), Positives = 31/55 (56%), Gaps = 4/55 (7%)
Query: 1520 AVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRKT 1574
A+Y + A N +ELS S Q + ++ D +WW E+NG G PSNY++ T
Sbjct: 1107 AMYDYAANNEDELSFSKGQLINVMNKDD----PDWWQGEINGVTGLFPSNYVKMT 1157
Score = 44.3 bits (103), Expect = 0.001
Identities = 37/132 (28%), Positives = 58/132 (43%), Gaps = 13/132 (9%)
Query: 13 FCPSVSEELPLFVGDIIEVLAVVDEFWLLGK-----KEDVTGQFPSSFVEIVTIPSLKEG 67
+ S SE+L L G +I +L W G+ K+ G FP+S V+++ PS +
Sbjct: 1037 YVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLG-PSSERA 1095
Query: 68 ERLFVCICE------FTSQELDNLPLHRGDLVILDGIPTAGWLQGRSCWGARGFFPSSCV 121
F +C+ + + D L +G L+ + W QG G G FPS+ V
Sbjct: 1096 TPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN-GVTGLFPSNYV 1154
Query: 122 RELCLSSQSRQW 133
+ S S+QW
Sbjct: 1155 KMTTDSDPSQQW 1166
Score = 38.9 bits (89), Expect = 0.040
Identities = 46/206 (22%), Positives = 79/206 (38%), Gaps = 31/206 (15%)
Query: 1392 VSFTSGSCQKQPQDASPPPKECDQGTLSAS---LNPSNSESSPSRCPSDPDSTSQPRSGD 1448
VS ++ S +P ++ P D +S S +N S + S P S S P G
Sbjct: 809 VSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVS-PIHGQ 867
Query: 1449 SADV----ARDVKQPTATPRSYRNFRHPEIVGYSVPGRN-------GQSQDLVKGCARTA 1497
V A+ + TA ++ NF +I+ N G K +
Sbjct: 868 GQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKII 927
Query: 1498 QAPEDRSTEPDGSEAEGN-----------QVYFAVYTFKARNPNELSVSANQKLKILEFK 1546
E + EP+ A N + Y A+Y + + P +L+ + +++ + + K
Sbjct: 928 PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQ-K 986
Query: 1547 DVTGNTEWWLAEVNGKKGYVPSNYIR 1572
D EWW + + G PSNY++
Sbjct: 987 D----GEWWTGSIGDRSGIFPSNYVK 1008
Score = 38.9 bits (89), Expect = 0.040
Identities = 19/54 (35%), Positives = 31/54 (57%)
Query: 7 VRAIFDFCPSVSEELPLFVGDIIEVLAVVDEFWLLGKKEDVTGQFPSSFVEIVT 60
V A++D+ + +EL G +I V+ D W G+ VTG FPS++V++ T
Sbjct: 1105 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1158
Score = 37.4 bits (85), Expect = 0.12
Identities = 18/56 (32%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 1518 YFAVYTFKARNPNELSVSANQKLKILEFKDVTGNTEWWLAEVNGKKGYVPSNYIRK 1573
Y A+Y F+ARN +E+S ++ +++ E G W G G+ P NY+ K
Sbjct: 735 YRALYPFEARNHDEMSFNSGDIIQVDE--KTVGEPGWLYGSFQGNFGWFPCNYVEK 788
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.315 0.133 0.386
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,693,817
Number of Sequences: 37866
Number of extensions: 3408173
Number of successful extensions: 15713
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 246
Number of HSP's successfully gapped in prelim test: 517
Number of HSP's that attempted gapping in prelim test: 12568
Number of HSP's gapped (non-prelim): 3220
length of query: 1577
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1461
effective length of database: 13,855,062
effective search space: 20242245582
effective search space used: 20242245582
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.