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Search of human proteins with 38570101
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
(1120 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 2258 0.0
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso... 1245 0.0
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 1158 0.0
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 1082 0.0
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 1070 0.0
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 1066 0.0
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 164 3e-40
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 147 4e-35
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 147 4e-35
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 140 9e-33
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 127 8e-29
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 125 3e-28
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 122 2e-27
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 122 2e-27
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 121 4e-27
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 119 1e-26
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 117 6e-26
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 112 2e-24
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 106 1e-22
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 103 1e-21
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 103 1e-21
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 94 9e-19
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 94 9e-19
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 94 9e-19
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 91 8e-18
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 81 5e-15
gi|226693407 TBC1 domain family, member 3H [Homo sapiens] 78 4e-14
gi|157502205 TBC1 domain family, member 3G [Homo sapiens] 78 4e-14
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 78 5e-14
gi|183583565 TBC1 domain family, member 3 [Homo sapiens] 77 7e-14
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1120
Score = 2258 bits (5851), Expect = 0.0
Identities = 1120/1120 (100%), Positives = 1120/1120 (100%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV
Sbjct: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR
Sbjct: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
Query: 121 GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL 180
GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL
Sbjct: 121 GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL 180
Query: 181 STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240
STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT
Sbjct: 181 STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240
Query: 241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK 300
YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK
Sbjct: 241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK 300
Query: 301 EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI 360
EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI
Sbjct: 301 EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI 360
Query: 361 ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL 420
ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL
Sbjct: 361 ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL 420
Query: 421 TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT 480
TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT
Sbjct: 421 TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT 480
Query: 481 RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL 540
RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL
Sbjct: 481 RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL 540
Query: 541 PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE 600
PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE
Sbjct: 541 PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE 600
Query: 601 RMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLSWFLTLFISVLPI 660
RMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLSWFLTLFISVLPI
Sbjct: 601 RMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLSWFLTLFISVLPI 660
Query: 661 ESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKDSPL 720
ESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKDSPL
Sbjct: 661 ESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKDSPL 720
Query: 721 PSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETT 780
PSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETT
Sbjct: 721 PSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETT 780
Query: 781 KQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCYWCLGCPVLKHHDPSLPYLEQYQIDC 840
KQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCYWCLGCPVLKHHDPSLPYLEQYQIDC
Sbjct: 781 KQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCYWCLGCPVLKHHDPSLPYLEQYQIDC 840
Query: 841 QQFRALYHLLSPWAHSANKDSLALWTFRLLDENSDCLINFKEFSSAIDIMYNGSFTEKLK 900
QQFRALYHLLSPWAHSANKDSLALWTFRLLDENSDCLINFKEFSSAIDIMYNGSFTEKLK
Sbjct: 841 QQFRALYHLLSPWAHSANKDSLALWTFRLLDENSDCLINFKEFSSAIDIMYNGSFTEKLK 900
Query: 901 LLFKLHIPPAYTEVKSKDASKGDELSKEELLYFSQLHVSKPANEKEAESAKHSPEKGKGK 960
LLFKLHIPPAYTEVKSKDASKGDELSKEELLYFSQLHVSKPANEKEAESAKHSPEKGKGK
Sbjct: 901 LLFKLHIPPAYTEVKSKDASKGDELSKEELLYFSQLHVSKPANEKEAESAKHSPEKGKGK 960
Query: 961 IDIQAYLSQWQDELFKKEENIKDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVT 1020
IDIQAYLSQWQDELFKKEENIKDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVT
Sbjct: 961 IDIQAYLSQWQDELFKKEENIKDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVT 1020
Query: 1021 SLLLRMEEVGRKLHSPTSSAKGFSGTVCGSGGPSEEKTGSHLEKDPCSFREEPQWSFAFE 1080
SLLLRMEEVGRKLHSPTSSAKGFSGTVCGSGGPSEEKTGSHLEKDPCSFREEPQWSFAFE
Sbjct: 1021 SLLLRMEEVGRKLHSPTSSAKGFSGTVCGSGGPSEEKTGSHLEKDPCSFREEPQWSFAFE 1080
Query: 1081 QILASLLNEPALVRFFEKPIDVKAKLENARISQLRSRTKM 1120
QILASLLNEPALVRFFEKPIDVKAKLENARISQLRSRTKM
Sbjct: 1081 QILASLLNEPALVRFFEKPIDVKAKLENARISQLRSRTKM 1120
>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
Length = 632
Score = 1245 bits (3222), Expect = 0.0
Identities = 613/614 (99%), Positives = 614/614 (100%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV
Sbjct: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR
Sbjct: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
Query: 121 GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL 180
GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL
Sbjct: 121 GLIAEEGKHCFAKEDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLYL 180
Query: 181 STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240
STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT
Sbjct: 181 STNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQT 240
Query: 241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK 300
YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK
Sbjct: 241 YLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESLK 300
Query: 301 EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI 360
EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI
Sbjct: 301 EVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSSKSVI 360
Query: 361 ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL 420
ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL
Sbjct: 361 ISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSESTEPSDNFEVQSL 420
Query: 421 TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT 480
TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT
Sbjct: 421 TSQRECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKT 480
Query: 481 RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL 540
RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL
Sbjct: 481 RDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSL 540
Query: 541 PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE 600
PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE
Sbjct: 541 PEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCE 600
Query: 601 RMLPDYFNRRIIGA 614
RMLPDYFNRRIIG+
Sbjct: 601 RMLPDYFNRRIIGS 614
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 1158 bits (2995), Expect = 0.0
Identities = 614/1143 (53%), Positives = 795/1143 (69%), Gaps = 44/1143 (3%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWLKPEEVLLKNALKLW+ ++S+ YF+LQRRRG+GE GGG LTG LVG LD+VLDS A+V
Sbjct: 1 MWLKPEEVLLKNALKLWVTQKSSCYFILQRRRGHGE-GGGRLTGRLVGALDAVLDSNARV 59
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
APFRIL Q P SQVY IACGA EEI +HWDWLEQN++ TLSVFD+ +DI +FV+GK++
Sbjct: 60 APFRILLQVPGSQVYSPIACGATLEEINQHWDWLEQNLLHTLSVFDNKDDIASFVKGKVK 119
Query: 121 GLIAEEGKHCFAK-EDDPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLY 179
LIAEE A+ E++PEKFREAL+KFE F PE EKLVTYYSC WKGRVP QGWLY
Sbjct: 120 ALIAEETSSRLAEQEEEPEKFREALVKFEARFNFPEAEKLVTYYSCCCWKGRVPRQGWLY 179
Query: 180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQ 239
LS N L FYSF LG E+KL++ W ++ KLE+TSNV LT++I + +Q + FSMFL++++
Sbjct: 180 LSINHLCFYSFFLGKELKLVVPWVDIQKLERTSNVFLTDTIRITTQNKERDFSMFLNLDE 239
Query: 240 TYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQITKRGLENRAHSEQFNAFFRLPKGESL 299
+ +MEQLA+ +RRL D E FD DP L P QITKR LE RA +E F AFFRLP+ E L
Sbjct: 240 VFKVMEQLADVTLRRLLDNEVFDLDPDLQEPSQITKRDLEARAQNEFFRAFFRLPRKEKL 299
Query: 300 KEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTNDSS--- 356
V +C LW PFS +T G+M S++YICFAS++ C +I+PLREV++I+K D+S
Sbjct: 300 HAVVDCSLWTPFSRCHTTGRMFASDSYICFASREDGCCKIILPLREVVSIEKMEDTSLLP 359
Query: 357 KSVIISIKGKTAFRFHEVKDFEQLVAKL--RLRCGAASTQYH------DISTELAISSES 408
+I+SI+ K AF+F E++D + LV L RL+ A+ H D L S S
Sbjct: 360 HPIIVSIRSKVAFQFIELRDRDSLVEALLARLKQVHANHPVHYDTSADDDMASLVFHSTS 419
Query: 409 TEPSDNF-EVQSLTSQ------RECSKTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSW 461
F +++ ++SQ +E S ++ +AL+T F ++ +S+M +E++K W
Sbjct: 420 MCSDHRFGDLEMMSSQNSEESEKEKSPLMHPDALVTAFQQSGSQSPDSRMSREQIKISLW 479
Query: 462 KILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQS 521
F E GR V MFRT+K R LV GIPE+LRG LW+LFS AV D+A++P YY +VE+S
Sbjct: 480 NDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLASHPGYYGNLVEES 539
Query: 522 LGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSV 581
LG C L TEEIERDL RSLPEHPAFQ++TGI+ALRRVLTAYA+RNPKIGYCQ+MNILTSV
Sbjct: 540 LGKCCLVTEEIERDLHRSLPEHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSMNILTSV 599
Query: 582 LLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTF 641
LLLY KEEEAFWLLVAVCERMLPDYFN R+IGA VDQ+VFEELI+ HLP+L EHM D++
Sbjct: 600 LLLYTKEEEAFWLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSA 659
Query: 642 FSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAE 701
+SVSLSWFLTLF+S++P+ESAVNVVDCFFYDGIKAI QLGLA+L+ N + L + KDD +
Sbjct: 660 LASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDLCSSKDDGQ 719
Query: 702 AVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGNIRYEDI 761
A+ L+RF D++ N+DSP P + SD++ + DI+DLIR+S EK+G+ E I
Sbjct: 720 ALMILSRFLDHIKNEDSPGPPVGSHHAFFSDDQEPYPVTDISDLIRDSYEKFGDQSVEQI 779
Query: 762 HSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCYWCLGCP 821
+R ++R+ V+Q E+TTKQNVLRVV +V + ++L+ELY +FK+E +SCYW P
Sbjct: 780 EHLRYKHRIRVLQGHEDTTKQNVLRVVIPEVSILPEDLEELYDLFKREHMMSCYWEQPRP 839
Query: 822 VLKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWTFRLLDENSDCLINFK 881
+ HDPS PY EQY+ID +QF L+ L+SPW A+ + LA TFRLLD+N D LI FK
Sbjct: 840 MASRHDPSRPYAEQYRIDARQFAHLFQLVSPWTCGAHTEILAERTFRLLDDNMDQLIEFK 899
Query: 882 EFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSKDASKGDELSKEELLYFSQLHVSKP 941
F S +DIMYNG EK+KLL++LHIPPA TE D L L L KP
Sbjct: 900 AFVSCLDIMYNGEMNEKIKLLYRLHIPPALTE---NDRDSQSPLRNPLLSTSRPLVFGKP 956
Query: 942 ANEKEAESAKHSPEKGKGKIDIQAYLSQWQDELFK-KEENIKDLPRMNQSQFIQFSKTLY 1000
+ +D Q L Q +L K K++ K+LP+M+Q +FIQF KTLY
Sbjct: 957 NGD---------------AVDYQKQLKQMIKDLAKEKDKTEKELPKMSQREFIQFCKTLY 1001
Query: 1001 NLFHEDPEEESLYQAIAVVTSLLLRMEEVGRKLHSPTSSAKGFSGTVCGSGGPSEEKTGS 1060
++FHEDPEE LYQAIA VT+LLL++ EVG++ S S ++ + S E+ +
Sbjct: 1002 SMFHEDPEENDLYQAIATVTTLLLQIGEVGQRGSSSGSCSQECGEELRASAPSPEDSVFA 1061
Query: 1061 HLEKDPCSFREEPQ-----WSFAFEQILASLLNEPALVRFFEKPIDVKAKLENARISQLR 1115
K P + P+ W+ + E ILASLL E +LV FFEKP+D+K+KLENA+I+Q
Sbjct: 1062 DTGKTPQDSQAFPEAAERDWTVSLEHILASLLTEQSLVNFFEKPLDMKSKLENAKINQYN 1121
Query: 1116 SRT 1118
+T
Sbjct: 1122 LKT 1124
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 1082 bits (2799), Expect = 0.0
Identities = 572/1099 (52%), Positives = 751/1099 (68%), Gaps = 53/1099 (4%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGG--LTGLLVGTLDSVLDSTA 58
MW+ PEEVLL NAL W+ ER+N YF+LQRR+G+ +GGGG L GLLVGTLD VLDS+A
Sbjct: 1 MWVNPEEVLLANAL--WITERANPYFILQRRKGHAGDGGGGGGLAGLLVGTLDVVLDSSA 58
Query: 59 KVAPFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGK 118
+VAP+RIL+QTPDS VY +IACG +R+EIT+HW+WLEQN+++TLS+F++ DIT FV+GK
Sbjct: 59 RVAPYRILYQTPDSLVYWTIACGGSRKEITEHWEWLEQNLLQTLSIFENENDITTFVRGK 118
Query: 119 IRGLIAEEGKHCFAKEDDP-EKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGW 177
I+G+IAE K KEDD EKF+EA++KF + FG+PE+EKLV YYSCSYWKG+VP QGW
Sbjct: 119 IQGIIAEYNKINDVKEDDDTEKFKEAIVKFHRLFGMPEEEKLVNYYSCSYWKGKVPRQGW 178
Query: 178 LYLSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHI 237
+YLS N L FYSFL+G E KL+I W ++++LEK + ++L + I V ++ H+FS+FL+I
Sbjct: 179 MYLSINHLCFYSFLMGREAKLVIRWVDITQLEKNATLLLPDVIKVSTRSSEHFFSVFLNI 238
Query: 238 NQTYLLMEQLANYAIRRLFDKETFDNDPVL-----YNPLQIT--KRGLENRAHSEQFNAF 290
N+T+ LMEQLAN A+R+L D E F+ D L +P +++ KR L+ RA SE++ A
Sbjct: 239 NETFKLMEQLANIAMRQLLDNEGFEQDRSLPKLKRKSPKKVSALKRDLDARAKSERYRAL 298
Query: 291 FRLPKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAID 350
FRLPK E L +C LW PF+ + G+M +S NYICF S++ N CS+IIPLREV ++
Sbjct: 299 FRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVE 358
Query: 351 KTNDSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTELAISSE 407
K + SS + IS + + F F +KD + LV ++ +++ + E A S
Sbjct: 359 KADSSSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSKIYS-DKEFAGSYN 417
Query: 408 STEPSDNFEVQSLTS---QRECSKTVN---------------TEALMTVFHPQNLETLNS 449
S++ SL S QR S + T+ LMT++ ++ E N
Sbjct: 418 SSDDEVYSRPSSLVSSSPQRSTSSDADGERQFNLNGNSVPTATQTLMTMYRRRSPEEFNP 477
Query: 450 KMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMAT 509
K+ KE +KEQ+WKI FAE G+G+ M+RT+KTR+LV++GIPE++RGELW+L SGA+N+ AT
Sbjct: 478 KLAKEFLKEQAWKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKAT 537
Query: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKI 569
+P YY ++VE+S+G NLATEEIERDL RSLPEHPAFQ++ GI+ALRRVLTAYA+RNP I
Sbjct: 538 HPGYYEDLVEKSMGKYNLATEEIERDLHRSLPEHPAFQNEMGIAALRRVLTAYAFRNPNI 597
Query: 570 GYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHL 629
GYCQAMNI+TSVLLLYAKEEEAFWLLVA+CERMLPDY+N R++GALVDQ VFEEL RD++
Sbjct: 598 GYCQAMNIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQGVFEELARDYV 657
Query: 630 PQLTEHMTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYN 689
PQL + M D+ S++SLSWFLTLF+SV+P ESAV VVDCFFY+GIK I QL LA+LD N
Sbjct: 658 PQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDAN 717
Query: 690 LDKLLTCKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRES 749
+DKLL CKDD EA+T L R+ D+VTNKDS LP S +SD+ + VDI LIR S
Sbjct: 718 VDKLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYPEVDIFRLIRTS 777
Query: 750 NEKYGNIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELDELYVIFKKE 809
EK+G IR + I MR + RL VIQTLE+TTK+NV+R + + ++ EL+ELY +FK E
Sbjct: 778 YEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKRNVVRTIVTETSFTIDELEELYALFKAE 837
Query: 810 LFLSCYWCLGCPVLKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWTFRL 869
SCYW L HDPSLPYLEQY+ID +QF+ ++ LL PWA + D LA F+L
Sbjct: 838 HLTSCYWGGSSNALDRHDPSLPYLEQYRIDFEQFKGMFALLFPWACGTHSDVLASRLFQL 897
Query: 870 LDENSDCLINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSKDASKGDELSKEE 929
LDEN D LINF+EF S + +G TEKLKLL+K+H+ P S D + D +
Sbjct: 898 LDENGDSLINFREFVSGLSAACHGDLTEKLKLLYKMHVLPE----PSSDQDEPDSAFEAT 953
Query: 930 LLYFSQL-----HV------SKPANEKEAESAKHSPEKGK--GKIDIQAYLSQWQDELFK 976
+F + HV SK + + P+KGK + + YL W E
Sbjct: 954 QYFFEDITPECTHVVGLDSRSKQGADDGFVTVSLKPDKGKRANSQENRNYLRLWTPENKS 1013
Query: 977 KEENIKDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVTSLLLRMEEVGRKL--H 1034
K +N KDLP++NQ QFI+ KT+YN+F EDP E+ LY A A VTSLLL + EVG+
Sbjct: 1014 KSKNAKDLPKLNQGQFIELCKTMYNMFSEDPNEQELYHATAAVTSLLLEIGEVGKLFVAQ 1073
Query: 1035 SPTSSAKGFSGTVCGSGGP 1053
G SG C G P
Sbjct: 1074 PAKEGGSGGSGPSCHQGIP 1092
Score = 48.1 bits (113), Expect = 5e-05
Identities = 21/45 (46%), Positives = 32/45 (71%)
Query: 1066 PCSFREEPQWSFAFEQILASLLNEPALVRFFEKPIDVKAKLENAR 1110
P S + W+ FEQ LASLL EPALV++F+KP+ + A++ +A+
Sbjct: 1200 PRSTSLDRDWAITFEQFLASLLTEPALVKYFDKPVCMMARITSAK 1244
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain) isoform
b [Homo sapiens]
Length = 1233
Score = 1070 bits (2766), Expect = 0.0
Identities = 563/1063 (52%), Positives = 734/1063 (69%), Gaps = 34/1063 (3%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWL PEEVL+ NAL W+ ER+N +FVLQRRRG+G GGGLTGLLVGTLD VLDS+A+V
Sbjct: 1 MWLSPEEVLVANAL--WVTERANPFFVLQRRRGHGR--GGGLTGLLVGTLDVVLDSSARV 56
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
AP+RILHQT DSQVY ++ACG++R+EITKHW+WLE N+++TLS+FDS EDIT FV+GKI
Sbjct: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
Query: 121 GLIAEEGKHCFAKED-DPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLY 179
G+IAEE K+ + D DP KF+EA LK K FG+PE EKLV YYSCSYWKGRVP QGWLY
Sbjct: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
Query: 180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQ 239
L+ N L FYSFLLG E+ L++ W ++++LEK + ++ ESI V ++ + +FSMFL+I +
Sbjct: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
Query: 240 TYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQ------ITKRGLENRAHSEQFNAFFRL 293
T+ LMEQLAN A+R+L D E F D L P++ KR L+ RA +E + A FRL
Sbjct: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRL 296
Query: 294 PKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTN 353
P+ E L C LW PF+ + G+M IS NYICFAS++ + C +IIPLREV ++K +
Sbjct: 297 PRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKAD 356
Query: 354 DSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRL-----------RCGAASTQYHDIS 399
SS + IS K K F F +KD + LV ++ G+ D S
Sbjct: 357 SSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPS 416
Query: 400 TELAISSESTEPSDNFEVQSLTSQRE-CSKTVNT--EALMTVFHPQN-LETLNSKMLKEK 455
TE + + + L+S++ C++ T + L+ +F + +E L +K KEK
Sbjct: 417 TESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEK 476
Query: 456 MKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYT 515
MKE+SW I F E GRGV M+RT KTR LV++GIPE+LRGELW+LFSGA N+M T+P YY
Sbjct: 477 MKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYA 536
Query: 516 EVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM 575
E+VE+S G +LATEEIERDL RS+PEHPAFQ++ GI+ALRRVLTAYA+RNP IGYCQAM
Sbjct: 537 ELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAM 596
Query: 576 NILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEH 635
NI+TSVLLLY EEEAFWLLVA+CERMLPDY+N R++GALVDQ +FEEL RD LPQL+E
Sbjct: 597 NIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEK 656
Query: 636 MTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLT 695
M D+ SS+SLSWFLTLF+SV+P ESAV +VDCFFY+GIK ILQ+ LA+LD N+++LL
Sbjct: 657 MQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLG 716
Query: 696 CKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGN 755
C D+ EA+T L R+ DNV NK S P + +S VDI +L++ S EK+ +
Sbjct: 717 CSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSS 776
Query: 756 IRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCY 815
+R EDI MR + RL VIQ+LE+T K++V+R + D+ S++EL++LY++FK + S Y
Sbjct: 777 LRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQY 836
Query: 816 WCLGCPVLKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWTFRLLDENSD 875
W + DPSLPYLEQY+ID QFR L+ L+PWA ++ LA FRLLDEN D
Sbjct: 837 WGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKD 896
Query: 876 CLINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSKDASKGDELSKEELLYFSQ 935
LINFKEF + + MY+G TEKLK+L+KLH+PPA + +++ A + E+ S
Sbjct: 897 SLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTED----SS 952
Query: 936 LHVSKPANEKEAE-SAKHSPEKGKGKIDIQAYLSQWQDELFKKEENIKDLPRMNQSQFIQ 994
+ P E+E S + EKG D + YL W E ++E IKDLP+MNQ QFI+
Sbjct: 953 SEEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLPKMNQEQFIE 1012
Query: 995 FSKTLYNLFHEDPEEESLYQAIAVVTSLLLRMEEVGRKLHSPT 1037
KTLYN+F EDP E+ LY AIA V SLLLR+ EVG+K + T
Sbjct: 1013 LCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSART 1055
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/39 (46%), Positives = 27/39 (69%)
Query: 1072 EPQWSFAFEQILASLLNEPALVRFFEKPIDVKAKLENAR 1110
+ W +FEQILAS+L E LV FFEK +D+ K+++ +
Sbjct: 1176 DTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQK 1214
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain) isoform
a [Homo sapiens]
Length = 1250
Score = 1066 bits (2757), Expect = 0.0
Identities = 565/1076 (52%), Positives = 737/1076 (68%), Gaps = 43/1076 (3%)
Query: 1 MWLKPEEVLLKNALKLWLMERSNDYFVLQRRRGYGEEGGGGLTGLLVGTLDSVLDSTAKV 60
MWL PEEVL+ NAL W+ ER+N +FVLQRRRG+G GGGLTGLLVGTLD VLDS+A+V
Sbjct: 1 MWLSPEEVLVANAL--WVTERANPFFVLQRRRGHGR--GGGLTGLLVGTLDVVLDSSARV 56
Query: 61 APFRILHQTPDSQVYLSIACGANREEITKHWDWLEQNIMKTLSVFDSNEDITNFVQGKIR 120
AP+RILHQT DSQVY ++ACG++R+EITKHW+WLE N+++TLS+FDS EDIT FV+GKI
Sbjct: 57 APYRILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIH 116
Query: 121 GLIAEEGKHCFAKED-DPEKFREALLKFEKCFGLPEKEKLVTYYSCSYWKGRVPCQGWLY 179
G+IAEE K+ + D DP KF+EA LK K FG+PE EKLV YYSCSYWKGRVP QGWLY
Sbjct: 117 GIIAEENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLY 176
Query: 180 LSTNFLSFYSFLLGSEIKLIISWDEVSKLEKTSNVILTESIHVCSQGENHYFSMFLHINQ 239
L+ N L FYSFLLG E+ L++ W ++++LEK + ++ ESI V ++ + +FSMFL+I +
Sbjct: 177 LTVNHLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGE 236
Query: 240 TYLLMEQLANYAIRRLFDKETFDNDPVLYNPLQ------ITKRGLENRAHSEQFNAFFRL 293
T+ LMEQLAN A+R+L D E F D L P++ KR L+ RA +E + A FRL
Sbjct: 237 TFKLMEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRL 296
Query: 294 PKGESLKEVHECFLWVPFSHFNTHGKMCISENYICFASQDGNQCSVIIPLREVLAIDKTN 353
P+ E L C LW PF+ + G+M IS NYICFAS++ + C +IIPLREV ++K +
Sbjct: 297 PRDERLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKAD 356
Query: 354 DSS---KSVIISIKGKTAFRFHEVKDFEQLVAKLRL-----------RCGAASTQYHDIS 399
SS + IS K K F F +KD + LV ++ G+ D S
Sbjct: 357 SSSVLPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPS 416
Query: 400 TELAISSESTEPSDNFEVQSLTSQRE-CSKTVNT--EALMTVFHPQN-LETLNSKMLKEK 455
TE + + + L+S++ C++ T + L+ +F + +E L +K KEK
Sbjct: 417 TESSPAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEK 476
Query: 456 MKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYT 515
MKE+SW I F E GRGV M+RT KTR LV++GIPE+LRGELW+LFSGA N+M T+P YY
Sbjct: 477 MKEESWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYA 536
Query: 516 EVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM 575
E+VE+S G +LATEEIERDL RS+PEHPAFQ++ GI+ALRRVLTAYA+RNP IGYCQAM
Sbjct: 537 ELVEKSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAM 596
Query: 576 NILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEH 635
NI+TSVLLLY EEEAFWLLVA+CERMLPDY+N R++GALVDQ +FEEL RD LPQL+E
Sbjct: 597 NIVTSVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEK 656
Query: 636 MTDMTFFSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLT 695
M D+ SS+SLSWFLTLF+SV+P ESAV +VDCFFY+GIK ILQ+ LA+LD N+++LL
Sbjct: 657 MQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLG 716
Query: 696 CKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGSNVSDEKTSHTRVDITDLIRESNEKYGN 755
C D+ EA+T L R+ DNV NK S P + +S VDI +L++ S EK+ +
Sbjct: 717 CSDEGEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSS 776
Query: 756 IRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELDELYVIFKKELFLSCY 815
+R EDI MR + RL VIQ+LE+T K++V+R + D+ S++EL++LY++FK + S Y
Sbjct: 777 LRAEDIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQY 836
Query: 816 WCLGCPVLKHHDPSLPYLEQYQIDCQQFRALYHLLSPWAHSANKDSLALWTFRLLDENSD 875
W + DPSLPYLEQY+ID QFR L+ L+PWA ++ LA FRLLDEN D
Sbjct: 837 WGCSRTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKD 896
Query: 876 CLINFKEFSSAIDIMYNGSFTEKLKLLFKLHIPPAYTEVKSKDASKG-----DELSKEEL 930
LINFKEF + + MY+G TEKLK+L+KLH+PPA + +++ A + ++ S E
Sbjct: 897 SLINFKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEAS 956
Query: 931 LYFSQLHVSKPANEKEA---------ESAKHSPEKGKGKIDIQAYLSQWQDELFKKEENI 981
S L + P +EA S + EKG D + YL W E ++E I
Sbjct: 957 PLASDLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETI 1016
Query: 982 KDLPRMNQSQFIQFSKTLYNLFHEDPEEESLYQAIAVVTSLLLRMEEVGRKLHSPT 1037
KDLP+MNQ QFI+ KTLYN+F EDP E+ LY AIA V SLLLR+ EVG+K + T
Sbjct: 1017 KDLPKMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSART 1072
Score = 43.5 bits (101), Expect = 0.001
Identities = 18/39 (46%), Positives = 27/39 (69%)
Query: 1072 EPQWSFAFEQILASLLNEPALVRFFEKPIDVKAKLENAR 1110
+ W +FEQILAS+L E LV FFEK +D+ K+++ +
Sbjct: 1193 DTDWCISFEQILASILTESVLVNFFEKRVDIGLKIKDQK 1231
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 164 bits (416), Expect = 3e-40
Identities = 89/240 (37%), Positives = 143/240 (59%), Gaps = 4/240 (1%)
Query: 472 VSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE 531
VS+ R++K R LV+ GIP +R +LWM SGA+ + Y E+V+ S +A ++
Sbjct: 99 VSLPRSEKLRSLVLAGIPHGMRPQLWMRLSGALQKKRNSELSYREIVKNSSNDETIAAKQ 158
Query: 532 IERDLRRSLPEHPAFQS--DTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEE 589
IE+DL R++P + F S G+ LRRVL A A+ P+IGYCQ ++ + LLL+ +EE
Sbjct: 159 IEKDLLRTMPSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEE 218
Query: 590 EAFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTF-FSSVSL 647
+AFW++ A+ E +LP YF+ ++G DQ V LI +LP+L + + + S ++L
Sbjct: 219 DAFWMMSAIIEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITL 278
Query: 648 SWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALN 707
WFLT F SV+ I+ + + D FFY+G + + QL L +L ++L+ ++ A L+
Sbjct: 279 HWFLTAFASVVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLS 338
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 147 bits (372), Expect = 4e-35
Identities = 99/324 (30%), Positives = 164/324 (50%), Gaps = 17/324 (5%)
Query: 401 ELAISSESTE-PSDNFEVQSLTSQ------RECSKTVNTEALMTVFHPQNLETLNSKMLK 453
E A+ ES E P F L S+ R + E L+ +L+TL +
Sbjct: 570 EDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQ 629
Query: 454 EKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWML----FSGAVNDMAT 509
E W+ FA M + + ++L+ GIP R ++W + D T
Sbjct: 630 EVSTGVKWENYFASTVNR-EMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDN-T 687
Query: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDT--GISALRRVLTAYAYRNP 567
P ++ +++++L N A+++IE DL R+LP + + T GI LR VL A+++RNP
Sbjct: 688 EPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNP 747
Query: 568 KIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIR 626
IGYCQ +N L +V LLY ++E+AFW LV + E +P DY+ + ++G+ VDQ VF +L+
Sbjct: 748 DIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMS 807
Query: 627 DHLPQLTEHMTDMTF-FSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAI 685
+ LP+L H ++ ++ +WFL +F+ + + + D F Y+G K I + LA+
Sbjct: 808 EKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALAL 867
Query: 686 LDYNLDKLLTCKDDAEAVTALNRF 709
Y +++L +D L F
Sbjct: 868 FKYKEEEILKLQDSMSIFKYLRYF 891
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 147 bits (372), Expect = 4e-35
Identities = 99/324 (30%), Positives = 164/324 (50%), Gaps = 17/324 (5%)
Query: 401 ELAISSESTE-PSDNFEVQSLTSQ------RECSKTVNTEALMTVFHPQNLETLNSKMLK 453
E A+ ES E P F L S+ R + E L+ +L+TL +
Sbjct: 570 EDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQ 629
Query: 454 EKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWML----FSGAVNDMAT 509
E W+ FA M + + ++L+ GIP R ++W + D T
Sbjct: 630 EVSTGVKWENYFASTVNR-EMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDN-T 687
Query: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDT--GISALRRVLTAYAYRNP 567
P ++ +++++L N A+++IE DL R+LP + + T GI LR VL A+++RNP
Sbjct: 688 EPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNP 747
Query: 568 KIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIR 626
IGYCQ +N L +V LLY ++E+AFW LV + E +P DY+ + ++G+ VDQ VF +L+
Sbjct: 748 DIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMS 807
Query: 627 DHLPQLTEHMTDMTF-FSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAI 685
+ LP+L H ++ ++ +WFL +F+ + + + D F Y+G K I + LA+
Sbjct: 808 EKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALAL 867
Query: 686 LDYNLDKLLTCKDDAEAVTALNRF 709
Y +++L +D L F
Sbjct: 868 FKYKEEEILKLQDSMSIFKYLRYF 891
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 140 bits (352), Expect = 9e-33
Identities = 91/268 (33%), Positives = 139/268 (51%), Gaps = 20/268 (7%)
Query: 433 EALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETL 492
+A F L TL + +K W L G GV RT K V +G+P
Sbjct: 25 DAAYEKFFSSYLVTLTRRAIK-------WSRLLQ--GGGVPRSRTVKR--YVRKGVPLEH 73
Query: 493 RGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEE-IERDLRRSLPEHPAFQSDTG 551
R +WM+ SGA M NP YY ++++ G N E+ I DL R+ P++ F+ T
Sbjct: 74 RARVWMVLSGAQAQMDQNPGYYHQLLQ---GERNPRLEDAIRTDLNRTFPDNVKFRKTTD 130
Query: 552 ISALR---RVLTAYAYRNPKIGYCQAMNILTSVLLLYAK-EEEAFWLLVAVCERMLPDYF 607
R VL AY + N +GYCQ MN + L+L EEE+FWLL A+ R+LPDY+
Sbjct: 131 PCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILPDYY 190
Query: 608 NRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLS-WFLTLFISVLPIESAVNV 666
+ ++G DQ V EL+R LP + M + ++ +S WF+ LF+ +LP+E+ + +
Sbjct: 191 SPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRI 250
Query: 667 VDCFFYDGIKAILQLGLAILDYNLDKLL 694
DC F +G K I ++ L ++ + + +L
Sbjct: 251 WDCLFNEGSKIIFRVALTLIKQHQELIL 278
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 127 bits (318), Expect = 8e-29
Identities = 81/258 (31%), Positives = 129/258 (50%), Gaps = 9/258 (3%)
Query: 455 KMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY 514
+ +E W + + ++ + KK R +GIP +LRG W SG + NP +
Sbjct: 80 RQRESKWLDMLNNWDKWMAK-KHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKF 138
Query: 515 TEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA--LRRVLTAYAYRNPKIGYC 572
E+ + S G + IERDL R P H F S G L RVL AY P+ GYC
Sbjct: 139 DEL-DMSPGDPKWL-DVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYC 196
Query: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQL 632
QA + +VLL++ E+AFW LV +CE+ LP Y++ ++ +D + L++ P
Sbjct: 197 QAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVA 256
Query: 633 TEHMTDMTFFSSVSLS-WFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNL- 690
+H++ + ++ WF+ F LP S + V D FF +G+K I ++GL +L + L
Sbjct: 257 HKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALG 316
Query: 691 --DKLLTCKDDAEAVTAL 706
+K+ C+ E + L
Sbjct: 317 SPEKVKACQGQYETIERL 334
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 125 bits (313), Expect = 3e-28
Identities = 108/372 (29%), Positives = 180/372 (48%), Gaps = 40/372 (10%)
Query: 456 MKEQSWKILFAECGRGVSMFRTKKTR---DLVVRGIPETLRGELWMLFSGAVNDMATNPD 512
++E +W IL+ +R +K + +L+ +GIP R +W L A + N
Sbjct: 82 LEEDTW-ILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ- 139
Query: 513 YYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIG 570
Y+E+++ S L I RD+ R+ PEH F Q G L V+ AY+ + ++G
Sbjct: 140 -YSELLKMSSPCEKL----IRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVG 194
Query: 571 YCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRI-------IGALVDQAVFEE 623
YCQ + +LL+ EEEAF + V R++ +Y R + +G + Q FE
Sbjct: 195 YCQGSAFIVGLLLMQMPEEEAFCVFV----RLMQEYRLRELFKPSMAELGLCIYQ--FEY 248
Query: 624 LIRDHLPQLTEHMTDMTFFSSV-SLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLG 682
++++ LP L H +F +S+ + SWFLTLF++ P+ A V D F Y+G++ + ++G
Sbjct: 249 MLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVG 308
Query: 683 LAILDYNLDKLLTCKDDAEAVTALNRFFDNVT--NKDSPLPSNVQQGSNVSDEKTSHTRV 740
LA+L N +L+ + ++++F V DS V + V R+
Sbjct: 309 LALLQVNQAELMQLD-----MEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRL 363
Query: 741 DITDLIRESNEKYGNIRYEDIHSMRCRNRLYV--IQTLEETTKQNVLRVVSQDVKLSLQE 798
+ +S E I +I +R NRL I+TLE+ + R++ V + QE
Sbjct: 364 EKEYAAMKSKEMEEQI---EIKRLRTENRLLKQRIETLEKESAALADRLIQGQVTRA-QE 419
Query: 799 LDELYVIFKKEL 810
+E YVI K+EL
Sbjct: 420 AEENYVI-KREL 430
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 122 bits (305), Expect = 2e-27
Identities = 107/370 (28%), Positives = 175/370 (47%), Gaps = 47/370 (12%)
Query: 456 MKEQSWKILFAECGRGVSMFRTKKTR---DLVVRGIPETLRGELWMLFSGAVNDMATNPD 512
++E +W IL+ +R +K + +L+ +GIP R +W L A + N
Sbjct: 82 LEEDTW-ILWGRIANEWEEWRRRKEKLLKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ- 139
Query: 513 YYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIG 570
Y+E+++ S L I RD+ R+ PEH F Q G L V+ AY+ + ++G
Sbjct: 140 -YSELLKMSSPCEKL----IRRDIARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVG 194
Query: 571 YCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRI-------IGALVDQAVFEE 623
YCQ + +LL+ EEEAF + V R++ +Y R + +G + Q FE
Sbjct: 195 YCQGSAFIVGLLLMQMPEEEAFCVFV----RLMQEYRLRELFKPSMAELGLCIYQ--FEY 248
Query: 624 LIRDHLPQLTEHMTDMTFFSSV-SLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLG 682
++++ LP L H +F +S+ + SWFLTLF++ P+ A V D F Y+G++ + ++G
Sbjct: 249 MLQEQLPDLNTHFRSQSFHTSMYASSWFLTLFLTTFPLPVATRVFDIFMYEGLEIVFRVG 308
Query: 683 LAILDYNLDKLLTCKDDAEAVTALNRFFDNVT--NKDSPLPSNVQQGSNVSDEKTSHTRV 740
LA+L N +L+ + ++++F V DS V + V R+
Sbjct: 309 LALLQVNQAELMQLD-----MEGMSQYFQRVIPHQFDSCPDKLVLKAYQVKYNPKKMKRL 363
Query: 741 DITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDVKLSLQELD 800
+ +S E I +I +R NRL + Q +E K V R QE +
Sbjct: 364 EKEYAAMKSKEMEEQI---EIKRLRTENRL-LKQRIETLEKGQVTRA---------QEAE 410
Query: 801 ELYVIFKKEL 810
E YVI K+EL
Sbjct: 411 ENYVI-KREL 419
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 122 bits (305), Expect = 2e-27
Identities = 79/269 (29%), Positives = 132/269 (49%), Gaps = 9/269 (3%)
Query: 455 KMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY 514
+ +E W +F+ + +S R +K + +GIP +LR + W S + + NP +
Sbjct: 329 RQRELKWLDMFSNWDKWLSR-RFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKF 387
Query: 515 TEVVEQSLGTCNLATEEIERDLRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIGYC 572
E+ E++ G + IE+DL R P H F + G L R+L AY P GYC
Sbjct: 388 EEL-ERAPGDPKWL-DVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 445
Query: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQL 632
QA + +VLL++ E+AFW LV +C++ LP Y++ + +D +F L+R P
Sbjct: 446 QAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLA 505
Query: 633 TEHMTDMTFFSSVSLS-WFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNL- 690
H+ + ++ WF+ +F LP S + V D FF +G+K I ++ L +L + L
Sbjct: 506 HRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLG 565
Query: 691 --DKLLTCKDDAEAVTALNRFFDNVTNKD 717
+KL +C+ E + L +D
Sbjct: 566 SVEKLRSCQGMYETMEQLRNLPQQCMQED 594
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 121 bits (303), Expect = 4e-27
Identities = 78/235 (33%), Positives = 114/235 (48%), Gaps = 6/235 (2%)
Query: 455 KMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYY 514
+ +E W + + + +S R KK + +GIP LR W L GA +P Y
Sbjct: 61 RQREMKWVEMTSHWEKTMSR-RYKKVKMQCRKGIPSALRARCWPLLCGAHVCQKNSPGTY 119
Query: 515 TEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALRRVLTAYAYRNPKIGYC 572
E+ E + T I RDL R P H F S G L +VL AY P+ GYC
Sbjct: 120 QELAEAPGDPQWMET--IGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYC 177
Query: 573 QAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQL 632
QA + +VLL++ EEAFW LV +CE LP Y+ + +D VF L+R LP +
Sbjct: 178 QAQGPVAAVLLMHLPPEEAFWCLVQICEVYLPGYYGPHMEAVRLDAEVFMALLRRLLPHV 237
Query: 633 TEHMTDMTFFSSVSL-SWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAIL 686
+H+ + + L WFL LF LP + + V D F +G + + ++GL ++
Sbjct: 238 HKHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLV 292
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 119 bits (299), Expect = 1e-26
Identities = 118/486 (24%), Positives = 220/486 (45%), Gaps = 62/486 (12%)
Query: 342 PLREVLAIDKTNDSSKSVIISIKGKTAFRFHEVKDFEQLVAKLRLRCGAASTQYHDISTE 401
P + +A DK + S + +K + H V VA + ST H S+
Sbjct: 13 PSGKQVATDKVAEKLSSTLSWVKNTVS---HTVSQMASQVA-------SPSTSLHTTSSS 62
Query: 402 LAISSESTEPS-------DNFEVQSLTSQRECSKTVNTEALMTVFHPQN------LETLN 448
+S+ + PS D+ E+ + ++ ++++L +V + + + +
Sbjct: 63 TTLSTPALSPSSPSQLSPDDLELLAKLEEQNRLLETDSKSLRSVNGSRRNSGSSLVSSSS 122
Query: 449 SKMLKEKMKEQSWKILFAEC---GRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVN 505
+ ++E SW IL+ V + K+ ++LV +GIP R +W L A +
Sbjct: 123 ASSNLSHLEEDSW-ILWGRIVNEWEDVRKKKEKQVKELVHKGIPHHFRAIVWQLLCSAQS 181
Query: 506 DMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQS--DTGISALRRVLTAYA 563
D Y+E+++ + L I RD+ R+ PEH F+ G L V+ AY+
Sbjct: 182 --MPIKDQYSELLKMTSPCEKL----IRRDIARTYPEHNFFKEKDSLGQEVLFNVMKAYS 235
Query: 564 YRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLPDYFNRRI-------IGALV 616
+ ++GYCQ + +LL+ EEEAF + V +++ DY R + +G +
Sbjct: 236 LVDREVGYCQGSAFIVGLLLMQMPEEEAFCVFV----KLMQDYRLRELFKPSMAELGLCM 291
Query: 617 DQAVFEELIRDHLPQLTEHMTDMTFFSSV-SLSWFLTLFISVLPIESAVNVVDCFFYDGI 675
Q FE +I++HLP+L H +F +S+ + SWFLT+F++ P+ A + D F +G+
Sbjct: 292 YQ--FECMIQEHLPELFVHFQSQSFHTSMYASSWFLTIFLTTFPLPIATRIFDIFMSEGL 349
Query: 676 KAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKDSPLPSNVQQGS---NVSD 732
+ + ++GLA+L N +L+ D E + L F + ++ +P + Q + +
Sbjct: 350 EIVFRVGLALLQMNQAELMQL--DMEGM--LQHFQKVIPHQFDGVPDKLIQAAYQVKYNS 405
Query: 733 EKTSHTRVDITDLIRESNEKYGNIRYEDIHSMRCRNRLYVIQTLEETTKQNVLRVVSQDV 792
+K + T + + E+ +I +R NRL + Q +E K ++D
Sbjct: 406 KKMKKLEKEYTTIKTKEMEE-----QVEIKRLRTENRL-LKQRIETLEKHKCSSNYNEDF 459
Query: 793 KLSLQE 798
L L++
Sbjct: 460 VLQLEK 465
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 117 bits (293), Expect = 6e-26
Identities = 88/313 (28%), Positives = 146/313 (46%), Gaps = 23/313 (7%)
Query: 412 SDNFEVQSLTSQRECS----KTVNTEALMTVFHPQNLETLNSKMLKEKMKEQSWKILFAE 467
SD+ E+ ++ E E L + Q LE+ + +L + ++ + +A
Sbjct: 549 SDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAA 608
Query: 468 CGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNL 527
G + + + + L+ G+P R +W P Y E++ + +
Sbjct: 609 LG---DLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHP 665
Query: 528 ATEEIERDLRRSLPEHPAFQSDTGI--SALRRVLTAYAYRNPKIGYCQAMNILTSVLLLY 585
A +IE DL R+ P + F T LRRVL A++++NP IGYCQ +N L ++ LL
Sbjct: 666 AARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLV 725
Query: 586 AKEEE-AFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIRDHLPQLTEHM-TDMTFF 642
+EEE AFW LVA+ E ++P DY+ + + VDQ V ++L+ + LP+L H+
Sbjct: 726 LEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDL 785
Query: 643 SSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEA 702
S V+ +WFL +F L + V D F Y+G K YN ++L ++ E
Sbjct: 786 SLVTFNWFLVVFADSLISNILLRVWDAFLYEGTK-----------YNEKEILRLQNGLEI 834
Query: 703 VTALNRFFDNVTN 715
L F ++N
Sbjct: 835 YQYLRFFTKTISN 847
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 112 bits (281), Expect = 2e-24
Identities = 76/250 (30%), Positives = 127/250 (50%), Gaps = 11/250 (4%)
Query: 449 SKMLKEKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMA 508
SK EK+ E +W L ++ +++ R K+ LV G+PE LRGE+W L +G N+
Sbjct: 530 SKECAEKILE-TWGELLSKWHLNLNV-RPKQLSSLVRNGVPEALRGEVWQLLAGCHNNDH 587
Query: 509 TNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSD--TGISALRRVLTAYAYRN 566
Y + ++S I RD+ R+ P H F+ G +L ++ AY+ +
Sbjct: 588 LVEKYRILITKESP-----QDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYD 642
Query: 567 PKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVC-ERMLPDYFNRRIIGALVDQAVFEELI 625
+IGYCQ + L +VLLL+ EE+AF +LV + + L + F + E L+
Sbjct: 643 EEIGYCQGQSFLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFEDLHCKFYQLERLM 702
Query: 626 RDHLPQLTEHMTDMTFFSSVSLS-WFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLA 684
++++P L H D++ + + S WFLTLF + P+ +++D +GI I + L
Sbjct: 703 QEYIPDLYNHFLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLLCEGISVIFNVALG 762
Query: 685 ILDYNLDKLL 694
+L + D LL
Sbjct: 763 LLKTSKDDLL 772
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 106 bits (264), Expect = 1e-22
Identities = 68/223 (30%), Positives = 109/223 (48%), Gaps = 9/223 (4%)
Query: 476 RTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERD 535
R K LV G+PE LR E+W L +G ++ A Y + + S I RD
Sbjct: 527 RPKGLSTLVKSGVPEALRAEVWQLLAGCHDNQAMLDRYRILITKDSA-----QESVITRD 581
Query: 536 LRRSLPEHPAFQSD--TGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFW 593
+ R+ P H F+ G +L ++ AY+ + IGYCQ + L +VLLL+ EE+AF
Sbjct: 582 IHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQAFC 641
Query: 594 LLVAVC-ERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVSLS-WFL 651
+LV + + L D + E L+++ LP L H +D+ + + S WFL
Sbjct: 642 VLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQWFL 701
Query: 652 TLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLL 694
TLF + P+ +++D +G+ I + LA+L + + LL
Sbjct: 702 TLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLL 744
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 103 bits (256), Expect = 1e-21
Identities = 71/285 (24%), Positives = 135/285 (47%), Gaps = 13/285 (4%)
Query: 440 HPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFR-TKKTRDLVVRGIPETLRGELWM 498
H + L N + ++K E + + +G ++ T+K + +GIP LRGE+W
Sbjct: 52 HEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWA 111
Query: 499 LFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALR 556
L D Y+++ ++ G C+ +I+ D+ R+ +H F+ G+ +L
Sbjct: 112 LLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLF 170
Query: 557 RVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVC---ERMLPDYFNRRIIG 613
VL AY+ N ++GYCQ M+ +T++LL+Y EE+AFW LV + + + +F +
Sbjct: 171 HVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPK 230
Query: 614 ALVDQAVFEELIRDHLPQLTEHMTDMTFFSS-VSLSWFLTLFISVLPIESAVNVVDCFFY 672
L Q E+++ L +L +H+ ++S ++ WF F+ P + + D + +
Sbjct: 231 LLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIF 290
Query: 673 DGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKD 717
+G + + + IL + L+ ++ L FF KD
Sbjct: 291 EGERVLTAMSYTILKLHKKHLMKL-----SMEELVEFFQETLAKD 330
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 103 bits (256), Expect = 1e-21
Identities = 71/285 (24%), Positives = 135/285 (47%), Gaps = 13/285 (4%)
Query: 440 HPQNLETLNSKMLKEKMKEQSWKILFAECGRGVSMFR-TKKTRDLVVRGIPETLRGELWM 498
H + L N + ++K E + + +G ++ T+K + +GIP LRGE+W
Sbjct: 69 HEEELPDHNVAVERQKHLEIERTTKWLKMLKGWEKYKNTEKFHRRIYKGIPLQLRGEVWA 128
Query: 499 LFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALR 556
L D Y+++ ++ G C+ +I+ D+ R+ +H F+ G+ +L
Sbjct: 129 LLLEIPKMKEETRDLYSKLKHRARG-CSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLF 187
Query: 557 RVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAVC---ERMLPDYFNRRIIG 613
VL AY+ N ++GYCQ M+ +T++LL+Y EE+AFW LV + + + +F +
Sbjct: 188 HVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPK 247
Query: 614 ALVDQAVFEELIRDHLPQLTEHMTDMTFFSS-VSLSWFLTLFISVLPIESAVNVVDCFFY 672
L Q E+++ L +L +H+ ++S ++ WF F+ P + + D + +
Sbjct: 248 LLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIF 307
Query: 673 DGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFDNVTNKD 717
+G + + + IL + L+ ++ L FF KD
Sbjct: 308 EGERVLTAMSYTILKLHKKHLMKL-----SMEELVEFFQETLAKD 347
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 93.6 bits (231), Expect = 9e-19
Identities = 70/264 (26%), Positives = 131/264 (49%), Gaps = 45/264 (17%)
Query: 487 GIPETLRGELWM------LFSGAVN---------DMATNPDYYTEVVEQSLGTCNLATEE 531
GIP+ R ++W+ L S A++ + +NPD + S+G +
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPD------DDSMGI------Q 133
Query: 532 IERDLRRS-LPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLL--LYAKE 588
I +DL R+ + +++ L+RVL AYA N +GYCQ NIL +++L + E
Sbjct: 134 IVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNE 193
Query: 589 EEAFWLLVAVCERMLPD-YFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSS--- 644
+A +++ + +++LP+ YF + VD AVF +L+R LP+L++H+ + ++
Sbjct: 194 GDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKES 253
Query: 645 -----------VSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKL 693
++ WFLTLF + LP ++ + + D F++G + IL++ LAI +++
Sbjct: 254 GGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
Query: 694 LTCKDDAEAVTALNRFFDNVTNKD 717
C+ E + + R + D
Sbjct: 314 ECCETADEFYSTMGRLTQEMLEND 337
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 93.6 bits (231), Expect = 9e-19
Identities = 70/264 (26%), Positives = 131/264 (49%), Gaps = 45/264 (17%)
Query: 487 GIPETLRGELWM------LFSGAVN---------DMATNPDYYTEVVEQSLGTCNLATEE 531
GIP+ R ++W+ L S A++ + +NPD + S+G +
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPD------DDSMGI------Q 133
Query: 532 IERDLRRS-LPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLL--LYAKE 588
I +DL R+ + +++ L+RVL AYA N +GYCQ NIL +++L + E
Sbjct: 134 IVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNE 193
Query: 589 EEAFWLLVAVCERMLPD-YFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSS--- 644
+A +++ + +++LP+ YF + VD AVF +L+R LP+L++H+ + ++
Sbjct: 194 GDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKES 253
Query: 645 -----------VSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKL 693
++ WFLTLF + LP ++ + + D F++G + IL++ LAI +++
Sbjct: 254 GGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
Query: 694 LTCKDDAEAVTALNRFFDNVTNKD 717
C+ E + + R + D
Sbjct: 314 ECCETADEFYSTMGRLTQEMLEND 337
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 93.6 bits (231), Expect = 9e-19
Identities = 70/264 (26%), Positives = 131/264 (49%), Gaps = 45/264 (17%)
Query: 487 GIPETLRGELWM------LFSGAVN---------DMATNPDYYTEVVEQSLGTCNLATEE 531
GIP+ R ++W+ L S A++ + +NPD + S+G +
Sbjct: 86 GIPKEWRRKVWLTLADHYLHSIAIDWDKTMRFTFNERSNPD------DDSMGI------Q 133
Query: 532 IERDLRRS-LPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLL--LYAKE 588
I +DL R+ + +++ L+RVL AYA N +GYCQ NIL +++L + E
Sbjct: 134 IVKDLHRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNE 193
Query: 589 EEAFWLLVAVCERMLPD-YFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSS--- 644
+A +++ + +++LP+ YF + VD AVF +L+R LP+L++H+ + ++
Sbjct: 194 GDALKIMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKES 253
Query: 645 -----------VSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKL 693
++ WFLTLF + LP ++ + + D F++G + IL++ LAI +++
Sbjct: 254 GGGYEPPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQI 313
Query: 694 LTCKDDAEAVTALNRFFDNVTNKD 717
C+ E + + R + D
Sbjct: 314 ECCETADEFYSTMGRLTQEMLEND 337
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 90.5 bits (223), Expect = 8e-18
Identities = 64/237 (27%), Positives = 107/237 (45%), Gaps = 15/237 (6%)
Query: 461 WKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWMLFSGAVNDMATNPDY------- 513
W+ + + GR F +K V +G+P RGE+W + + P
Sbjct: 774 WEKMLSTPGRSKIKFDMEKMHSAVGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVP 833
Query: 514 YTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGIS--ALRRVLTAYAYRNPKIGY 571
Y E+++Q I DL R+ P HP F + G +L +L AY+ + ++GY
Sbjct: 834 YKELLKQLTSQ----QHAILIDLGRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGY 889
Query: 572 CQAMNILTSVLLLYAKEEEAFWLLVAVCERM-LPDYFNRRIIGALVDQAVFEELIRDHLP 630
CQ ++ + +LLL+ EEEAF +L + M L + +I + L+ D+
Sbjct: 890 CQGLSFVAGILLLHMSEEEAFKMLKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHR 949
Query: 631 QLTEHMTDMTFFSSV-SLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAIL 686
L H+ + S+ + WFLT+F S P+ V D F G + I ++ L++L
Sbjct: 950 DLYNHLEEHEIGPSLYAAPWFLTMFASQFPLGFVARVFDMIFLQGTEVIFKVALSLL 1006
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 81.3 bits (199), Expect = 5e-15
Identities = 61/246 (24%), Positives = 109/246 (44%), Gaps = 15/246 (6%)
Query: 483 LVVRGIPETLRGELWMLFS------GAVNDMATNPDY-YTEVVEQSLGTCNLATEEIERD 535
L+ G+P++ RGE+W + + + PD Y E+++Q I D
Sbjct: 914 LLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQ----LTAQQHAILVD 969
Query: 536 LRRSLPEHPAF--QSDTGISALRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFW 593
L R+ P HP F Q G +L +L AY+ + ++GYCQ ++ + VLLL+ EE+AF
Sbjct: 970 LGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFE 1029
Query: 594 LL-VAVCERMLPDYFNRRIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSV-SLSWFL 651
+L + + + ++ + L+ D+ L H+ + S+ + WFL
Sbjct: 1030 MLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFL 1089
Query: 652 TLFISVLPIESAVNVVDCFFYDGIKAILQLGLAILDYNLDKLLTCKDDAEAVTALNRFFD 711
TLF S + V D F G + I ++ L++L ++ C+ V L
Sbjct: 1090 TLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLP 1149
Query: 712 NVTNKD 717
++ +
Sbjct: 1150 DMNTSE 1155
>gi|226693407 TBC1 domain family, member 3H [Homo sapiens]
Length = 549
Score = 78.2 bits (191), Expect = 4e-14
Identities = 74/323 (22%), Positives = 136/323 (42%), Gaps = 32/323 (9%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAV--CERMLPDYF---NR 609
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV + ER F N
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNG 229
Query: 610 RIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVS-LSWFLTLFISVLPIESAVNVVD 668
+ L DQ E ++ P+ H S L + + I + + + + D
Sbjct: 230 GTVQGLQDQQ--EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWD 287
Query: 669 CFFYDGIKAIL---QLGLAILDYNLDKLLTC---------------KDDAEAVTALNRFF 710
+ +G +A++ ++ + L K C +D+ + L
Sbjct: 288 VYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASM 347
Query: 711 DNVTNK--DSPLPSNVQQGSNVS 731
+T K D P P+ +QGS+ S
Sbjct: 348 KKLTRKQGDLPPPAKPEQGSSAS 370
>gi|157502205 TBC1 domain family, member 3G [Homo sapiens]
Length = 549
Score = 78.2 bits (191), Expect = 4e-14
Identities = 74/323 (22%), Positives = 136/323 (42%), Gaps = 32/323 (9%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDISGTLRKHMFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAV--CERMLPDYF---NR 609
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV + ER F N
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNG 229
Query: 610 RIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVS-LSWFLTLFISVLPIESAVNVVD 668
+ L DQ E ++ P+ H S L + + I + + + + D
Sbjct: 230 GTVQGLQDQQ--EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWD 287
Query: 669 CFFYDGIKAIL---QLGLAILDYNLDKLLTC---------------KDDAEAVTALNRFF 710
+ +G +A++ ++ + L K C +D+ + L
Sbjct: 288 VYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASM 347
Query: 711 DNVTNK--DSPLPSNVQQGSNVS 731
+T K D P P+ +QGS+ S
Sbjct: 348 KKLTRKQGDLPPPAKPEQGSSAS 370
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 77.8 bits (190), Expect = 5e-14
Identities = 74/323 (22%), Positives = 136/323 (42%), Gaps = 32/323 (9%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNTEEMKLKNPGRY-QIMKEKGKKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAV--CERMLPDYF---NR 609
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV + ER F N
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNG 229
Query: 610 RIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVS-LSWFLTLFISVLPIESAVNVVD 668
+ L DQ E ++ P+ H S L + + I + + + + D
Sbjct: 230 GTVQGLQDQQ--EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWD 287
Query: 669 CFFYDGIKAIL---QLGLAILDYNLDKLLTC---------------KDDAEAVTALNRFF 710
+ +G +A++ ++ + L K C +D+ + L
Sbjct: 288 VYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASM 347
Query: 711 DNVTNK--DSPLPSNVQQGSNVS 731
+T K D P P+ +QGS+ S
Sbjct: 348 KKLTRKKGDLPPPAKPEQGSSAS 370
>gi|183583565 TBC1 domain family, member 3 [Homo sapiens]
Length = 549
Score = 77.4 bits (189), Expect = 7e-14
Identities = 74/323 (22%), Positives = 136/323 (42%), Gaps = 32/323 (9%)
Query: 438 VFHPQNLETLNSKMLKEKMKEQSWKILFAEC-GRGVSMFRTKKTRDLVVRGIPETLRGEL 496
+ H L L ++ K+ +E S K + + G ++K D +G+P +RG +
Sbjct: 51 IVHETELPPLTAREAKQIRREISRKSKWVDMLGDWEKYKSSRKLIDRAYKGMPMNIRGPM 110
Query: 497 WMLFSGAVNDMATNPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDTGISA-- 554
W + NP Y +++++ + + I+RD+ +L +H F+ G
Sbjct: 111 WSVLLNIEEMKLKNPGRY-QIMKEKGKRSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRE 169
Query: 555 LRRVLTAYAYRNPKIGYCQAMNILTSVLLLYAKEEEAFWLLVAV--CERMLPDYF---NR 609
L +L AY NP++GYC+ ++ + ++ LLY EE+AFW LV + ER F N
Sbjct: 170 LLHILLAYEEYNPEVGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNG 229
Query: 610 RIIGALVDQAVFEELIRDHLPQLTEHMTDMTFFSSVS-LSWFLTLFISVLPIESAVNVVD 668
+ L DQ E ++ P+ H S L + + I + + + + D
Sbjct: 230 GTVQGLQDQQ--EHVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWD 287
Query: 669 CFFYDGIKAIL---QLGLAILDYNLDKLLTC---------------KDDAEAVTALNRFF 710
+ +G +A++ ++ + L K C +D+ + L
Sbjct: 288 VYLVEGEQALMPITRIAFKVQQKRLTKTSRCGPWARFCNRFVDTWARDEDTVLKHLRASM 347
Query: 711 DNVTNK--DSPLPSNVQQGSNVS 731
+T K D P P+ +QGS+ S
Sbjct: 348 KKLTRKKGDLPPPAKPEQGSSAS 370
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.399
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,142,265
Number of Sequences: 37866
Number of extensions: 1816296
Number of successful extensions: 5217
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 74
Number of HSP's successfully gapped in prelim test: 43
Number of HSP's that attempted gapping in prelim test: 4919
Number of HSP's gapped (non-prelim): 221
length of query: 1120
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1007
effective length of database: 13,968,660
effective search space: 14066440620
effective search space used: 14066440620
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.