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Search of human proteins with 124430557
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
(1910 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 4113 0.0
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 2070 0.0
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 694 0.0
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 639 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 613 e-175
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 603 e-172
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 580 e-165
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 556 e-158
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 550 e-156
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 547 e-155
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 534 e-151
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 532 e-150
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 505 e-142
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 455 e-127
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 454 e-127
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 453 e-127
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 445 e-124
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 419 e-116
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 416 e-116
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 409 e-113
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 409 e-113
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 385 e-106
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 320 1e-86
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 287 8e-77
gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo s... 282 2e-75
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 269 2e-71
gi|145309328 papilin [Homo sapiens] 269 2e-71
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 205 3e-52
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 192 3e-48
gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo s... 191 4e-48
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 4113 bits (10668), Expect = 0.0
Identities = 1910/1910 (100%), Positives = 1910/1910 (100%)
Query: 1 MWVAKWLTGLLYHLSLFITRSWEVDFHPRQEALVRTLTSYEVVIPERVNEFGEVFPQSHH 60
MWVAKWLTGLLYHLSLFITRSWEVDFHPRQEALVRTLTSYEVVIPERVNEFGEVFPQSHH
Sbjct: 1 MWVAKWLTGLLYHLSLFITRSWEVDFHPRQEALVRTLTSYEVVIPERVNEFGEVFPQSHH 60
Query: 61 FSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESD 120
FSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESD
Sbjct: 61 FSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESD 120
Query: 121 AGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHN 180
AGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHN
Sbjct: 121 AGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHN 180
Query: 181 KPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNV 240
KPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNV
Sbjct: 181 KPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNV 240
Query: 241 PLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIG 300
PLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIG
Sbjct: 241 PLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIG 300
Query: 301 NLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITRE 360
NLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITRE
Sbjct: 301 NLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITRE 360
Query: 361 DICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCK 420
DICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCK
Sbjct: 361 DICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCK 420
Query: 421 EMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPG 480
EMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPG
Sbjct: 421 EMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPG 480
Query: 481 SRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHC 540
SRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHC
Sbjct: 481 SRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHC 540
Query: 541 RHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRM 600
RHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRM
Sbjct: 541 RHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRM 600
Query: 601 KFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQV 660
KFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQV
Sbjct: 601 KFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQV 660
Query: 661 AGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSC 720
AGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSC
Sbjct: 661 AGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSC 720
Query: 721 KTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLL 780
KTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLL
Sbjct: 721 KTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLL 780
Query: 781 STSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIP 840
STSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIP
Sbjct: 781 STSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIP 840
Query: 841 LEERSDMFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSC 900
LEERSDMFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSC
Sbjct: 841 LEERSDMFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSC 900
Query: 901 NTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQEL 960
NTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQEL
Sbjct: 901 NTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQEL 960
Query: 961 CHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEF 1020
CHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEF
Sbjct: 961 CHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEF 1020
Query: 1021 SCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASW 1080
SCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASW
Sbjct: 1021 SCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASW 1080
Query: 1081 QVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL 1140
QVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL
Sbjct: 1081 QVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL 1140
Query: 1141 ETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAE 1200
ETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAE
Sbjct: 1141 ETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAE 1200
Query: 1201 IWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSL 1260
IWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSL
Sbjct: 1201 IWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSL 1260
Query: 1261 AACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC 1320
AACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC
Sbjct: 1261 AACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC 1320
Query: 1321 SGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKS 1380
SGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKS
Sbjct: 1321 SGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKS 1380
Query: 1381 RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYR 1440
RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYR
Sbjct: 1381 RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYR 1440
Query: 1441 EVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYC 1500
EVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYC
Sbjct: 1441 EVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYC 1500
Query: 1501 RLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTD 1560
RLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTD
Sbjct: 1501 RLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTD 1560
Query: 1561 NQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPS 1620
NQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPS
Sbjct: 1561 NQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPS 1620
Query: 1621 TKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVK 1680
TKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVK
Sbjct: 1621 TKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVK 1680
Query: 1681 CITKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTCKEIQVKNHIRKDGDYYLNIKGRIIK 1740
CITKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTCKEIQVKNHIRKDGDYYLNIKGRIIK
Sbjct: 1681 CITKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTCKEIQVKNHIRKDGDYYLNIKGRIIK 1740
Query: 1741 IYCADMYLENPKEYLTLVQGEENFSEVYGFRLKNPYQCPFNGSRREDCECDNGHLAAGYT 1800
IYCADMYLENPKEYLTLVQGEENFSEVYGFRLKNPYQCPFNGSRREDCECDNGHLAAGYT
Sbjct: 1741 IYCADMYLENPKEYLTLVQGEENFSEVYGFRLKNPYQCPFNGSRREDCECDNGHLAAGYT 1800
Query: 1801 VFSKIRIDLTSMQIKTTDLLFSKTIFGNAVPFATAGDCYSAFRCPQGQFSINLSGTGMKI 1860
VFSKIRIDLTSMQIKTTDLLFSKTIFGNAVPFATAGDCYSAFRCPQGQFSINLSGTGMKI
Sbjct: 1801 VFSKIRIDLTSMQIKTTDLLFSKTIFGNAVPFATAGDCYSAFRCPQGQFSINLSGTGMKI 1860
Query: 1861 SSTAKWLTQGSYTSVSIRRSEDGTRFFGKCGGYCGKCLPHMTTGLPIQVI 1910
SSTAKWLTQGSYTSVSIRRSEDGTRFFGKCGGYCGKCLPHMTTGLPIQVI
Sbjct: 1861 SSTAKWLTQGSYTSVSIRRSEDGTRFFGKCGGYCGKCLPHMTTGLPIQVI 1910
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 2070 bits (5364), Expect = 0.0
Identities = 969/1923 (50%), Positives = 1300/1923 (67%), Gaps = 61/1923 (3%)
Query: 27 HPRQEALVRTLTSYEVVIPERVNEFGEVFPQSHHFSRQKRS-SEALEPMPF--------- 76
HPRQ L+ TL+ YE+V P RVN GE FP + HF R +RS + A +P P
Sbjct: 35 HPRQVKLLETLSEYEIVSPIRVNALGEPFPTNVHFKRTRRSINSATDPWPAFASSSSSST 94
Query: 77 --RTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTP--ERGAWESDAGPSDLRHCFYR 132
+ HYR +A+GQ F NLTA+A F+A +T LGTP + + S+ ++L+HCFY+
Sbjct: 95 SSQAHYRLSAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEE-EAELKHCFYK 153
Query: 133 GQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNN 192
G VN+ ++ AV+SLC G+ GTF+ +G+YF+EP+ D E E+ NKPH+IYR+
Sbjct: 154 GYVNTNSEHTAVISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQ 213
Query: 193 SFLQTLKY-CSVSESQIKETSLPFHTYS-------NMNEDLNVMK-----ERVLGHTSKN 239
T ++ C SE + + + T + N+ D+ + E + +K
Sbjct: 214 REPSTGRHACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKT 273
Query: 240 VPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSI 299
+++R H R KR +SYPR++E++V AD ++VS HG NLQ+YILTLMSIVA+IYKDPSI
Sbjct: 274 DNTREKRTHRRTKRFLSYPRFVEVLVVADNRMVSYHGENLQHYILTLMSIVASIYKDPSI 333
Query: 300 GNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITR 359
GNLI+IV+V L++IH E++GP I+F+ TTLKNFC WQ ++N +H HDTAVL+TR
Sbjct: 334 GNLINIVIVNLIVIHNEQDGPSISFNAQTTLKNFCQWQHSKNSPGGIH---HDTAVLLTR 390
Query: 360 EDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRC 419
+DIC + +KC+ LGL+ LGTICDP +SC I+E+ GL +AFTIAHELGH + HDDN +C
Sbjct: 391 QDICRAHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHDDNNKC 450
Query: 420 KEMKV-TKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSEL 478
KE V + HVMAP L+F+ +PW WS CSRKY+TEFLDTGYGECLL++P+ Y LP +L
Sbjct: 451 KEEGVKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQL 510
Query: 479 PGSRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGM 538
PG Y+ NKQCEL FGPGSQ+CP++ C LWC + +HKGC TQH P ADGT+C PG
Sbjct: 511 PGILYNVNKQCELIFGPGSQVCPYMMQCRRLWCNNVNGVHKGCRTQHTPWADGTECEPGK 570
Query: 539 HCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGR 598
HC++G CV KE + +G WG W P+ +CSRTCGGGI++A R CNRPEP+NGG YCVGR
Sbjct: 571 HCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGR 630
Query: 599 RMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYC 658
RMKF+SCNT+ C K +DFR++QC+ F+GKH +I+G+ NVRW+P+YSGI KDRCKL+C
Sbjct: 631 RMKFKSCNTEPCLKQKRDFRDEQCAHFDGKHFNINGLLPNVRWVPKYSGILMKDRCKLFC 690
Query: 659 QVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNS 718
+VAG +Y L+D V DGTPCG +T+DICVQG C AGCDHVLNS A+ DKCGVCGGDNS
Sbjct: 691 RVAGNTAYYQLRDRVIDGTPCGQDTNDICVQGLCRQAGCDHVLNSKARRDKCGVCGGDNS 750
Query: 719 SCKTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQ-PDDSYLALSDAEGNFLFNGN 777
SCKT+ G FN+ HYGYN VV+IPAGATN+D+RQ+S+SG+ DD+YLALS ++G FL NGN
Sbjct: 751 SCKTVAGTFNTVHYGYNTVVRIPAGATNIDVRQHSFSGETDDDNYLALSSSKGEFLLNGN 810
Query: 778 FLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSF 837
F+++ +K+EI + V+EYSGS AVERINST+R E+EL+LQVL VG LYNPDV YSF
Sbjct: 811 FVVTMAKREIRI--GNAVVEYSGSETAVERINSTDRIEQELLLQVLSVGKLYNPDVRYSF 868
Query: 838 NIPLEERSDMFTWDPYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVT 897
NIP+E++ F W+ +GPW+ C+K CQG ++R + C +SD VSD+ CD LP P +T
Sbjct: 869 NIPIEDKPQQFYWNSHGPWQACSKPCQGERKRKLVCTRESDQLTVSDQRCDRLPQPGHIT 928
Query: 898 QSCNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPT 957
+ C TDC+LRWHV +SECS+QCG GYRTLDI+C KYS +G+T +VDD +C KP
Sbjct: 929 EPCGTDCDLRWHVASRSECSAQCGLGYRTLDIYCAKYSRLDGKTEKVDDGFCSSHPKPSN 988
Query: 958 QELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENC 1017
+E C G C W YS W++CS+SC GG + R + C+N L D++C +VT + C
Sbjct: 989 REKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQEKVTIQRC 1048
Query: 1018 NEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
+EF CP W + +WSECLVTCGKG K RQVWCQ D L+D C+ TKP S+ C+ C
Sbjct: 1049 SEFPCPQWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRMCDPETKPTSMQTCQQPEC 1108
Query: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFI 1137
ASWQ GPWG C+ TCG GYQ+R VKC+ +V++D +C+ A+RP+D Q C L C
Sbjct: 1109 ASWQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSCHPP 1168
Query: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPR 1197
T + QWR GSWTPCS +CG+GT+ RYVSCRD +ADES CA LPR
Sbjct: 1169 PAAPETRRSTYSAPR-TQWRFGSWTPCSATCGKGTRMRYVSCRDENGSVADESACATLPR 1227
Query: 1198 PAEIWDC-FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNY-HQPIDENYCDPEVRPLME 1255
P +C TPCG+W+A DWS CS +CG G+ TRQV+C+NY ID + CD + P +
Sbjct: 1228 PVAKEECSVTPCGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETD 1287
Query: 1256 QECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPS----VRGNQWRTG 1311
Q+CS++ CP P S + + + ED + PS + GNQWRTG
Sbjct: 1288 QDCSMSPCP---QRTPDSGLAQHPFQN---------EDYRPRSASPSRTHVLGGNQWRTG 1335
Query: 1312 PWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECS 1371
PWG+CSS+C+GG Q R VVCQDENG +A+ C KP E + C GPCPQW YGNWGEC+
Sbjct: 1336 PWGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCPQWAYGNWGECT 1395
Query: 1372 QTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSA 1431
+ CGGGI++RLV+CQ NG+ D +CEI++KPP QC+ HACP D +W PW+SCS
Sbjct: 1396 KLCGGGIRTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACPHDAAWSTGPWSSCSV 1455
Query: 1432 SCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGS 1491
SCG+G K R V+C+ + LE C + KP H+ CR RCP WKA +W++CSV+CG
Sbjct: 1456 SCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPKWKAGAWSQCSVSCGR 1515
Query: 1492 GVQQRDVYCRLKGVGQVVEEM-CDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERK 1550
GVQQR V C++ G ++ E C+ TRP S+R C C + C+ +C
Sbjct: 1516 GVQQRHVGCQI-GTHKIARETECNPYTRPESERDCQGPRCPLYTWRAEEWQECTKTCGEG 1574
Query: 1551 DSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQ 1610
++++ C D+ +V+ + S + ++C PC Y+ +T + S+C+ CG Y+Q
Sbjct: 1575 SRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPCEYVWITGEWSECSVTCGKGYKQ 1634
Query: 1611 RITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQC-INSCLHLATWKVGKWSKCSVT 1669
R+ C+EI + K++ + + + CP V+ C + C ATW+VG W CSV+
Sbjct: 1635 RLVSCSEIYTGKENYEYSYQTTI--NCPGTQPPSVHPCYLRDCPVSATWRVGNWGSCSVS 1692
Query: 1670 CGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKC-YANDCKSFTTCKEIQVKNHIRKDG 1728
CG+G+M+R V+C+T S LC LKP +K C +C+ CKE++ +DG
Sbjct: 1693 CGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCRNVYNCELPQNCKEVKRLKGASEDG 1752
Query: 1729 DYYLNIKGRIIKIYCADMYLENPKEYLTLVQGE-ENFSEVYGFRLKNPYQCPFNGSRRED 1787
+Y+L I+G+++KI+CA M+ ++PKEY+TLV G+ ENFSEVYG RL NP +CP+NGSRR+D
Sbjct: 1753 EYFLMIRGKLLKIFCAGMHSDHPKEYVTLVHGDSENFSEVYGHRLHNPTECPYNGSRRDD 1812
Query: 1788 CECDNGHLAAGYTVFSKIRIDLTSMQIKTTDLLFSKTIFGNAVPFATAGDCYSAFRCPQG 1847
C+C + AAG++ F KIRIDLTSMQI TTDL F++T G+ VPFATAGDCYSA +CPQG
Sbjct: 1813 CQCRKDYTAAGFSSFQKIRIDLTSMQIITTDLQFARTSEGHPVPFATAGDCYSAAKCPQG 1872
Query: 1848 QFSINLSGTGMKISSTAKWLTQGSYTSVSIRRSEDGTRFFGKCGGYCGKCLPHMTTGLPI 1907
+FSINL GTG+ ++ +A+W++QG+Y I++S DGTR GKCGGYCGKC P TGL +
Sbjct: 1873 RFSINLYGTGLSLTESARWISQGNYAVSDIKKSPDGTRVVGKCGGYCGKCTPSSGTGLEV 1932
Query: 1908 QVI 1910
+V+
Sbjct: 1933 RVL 1935
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin type)
with thrombospondin type 1 motif, 15 preproprotein [Homo
sapiens]
Length = 950
Score = 694 bits (1792), Expect = 0.0
Identities = 370/935 (39%), Positives = 528/935 (56%), Gaps = 64/935 (6%)
Query: 80 YRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQE 139
++ TA+ + F L+LT DA FLA ++ HLG P +G G SDLR CFY G VN++
Sbjct: 55 FQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGL---TGGSSDLRRCFYSGDVNAEP 111
Query: 140 DYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLK 199
D A VSLCGGL G F + EY + P+ A + HL+ R+ +
Sbjct: 112 DSFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQGAHLLQRRGVPGG------ 165
Query: 200 YCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPR 259
S + + L+ K R G + RR R KR +S PR
Sbjct: 166 ---PSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGES----RSRRRSGRAKRFVSIPR 218
Query: 260 YIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEG 319
Y+E +V AD +V HG++L++Y+LTL++ A +Y+ PSI N I+IVVVK++++ + G
Sbjct: 219 YVETLVVADESMVKFHGADLEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSG 278
Query: 320 PVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGT 379
P + + A TL+NFC+WQ+ N + D HP + DTA+L TR+D+C + C+ LG++ +GT
Sbjct: 279 PKVTGNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATT-CDTLGMADVGT 337
Query: 380 ICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEM--KVTKYHVMAPALSFH 437
+CDP +SC + E+ GL SAFT AHELGH + HD+ C+E+ K+ H+M+P L
Sbjct: 338 MCDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQI 397
Query: 438 MSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGS 497
WS CS +T+FLD+G+G+CLLD+P + I +LP +LPG+ Y ++QCELAFG GS
Sbjct: 398 DRANPWSACSAAIITDFLDSGHGDCLLDQPSKPI-SLPEDLPGASYTLSQQCELAFGVGS 456
Query: 498 QMCPHINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRP-VN 556
+ CP++ C LWCT K C T+H P ADGT CG G C G CV + + V+
Sbjct: 457 KPCPYMQYCTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKHRVD 516
Query: 557 GEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGT-- 614
G W W+PY CSRTCGGG++ A R+C P P NGG YC G R+K+RSCN + CP
Sbjct: 517 GSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSSASG 576
Query: 615 QDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVE 674
+ FRE+QC FNG + + + V W+P+YSG+ +D+CKL C+ GT YFY+L V
Sbjct: 577 KSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAPKVV 636
Query: 675 DGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYGY 734
DGT C ++ +CVQG+C+ AGCD L S + DKCGVCGGDN SCK +TG+F +GY
Sbjct: 637 DGTLCSPDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTKPMHGY 696
Query: 735 NVVVKIPAGATNVDIRQYSYSGQ-PDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTR 793
N VV IPAGA+++DIRQ Y G DD+YLAL +++G +L NG+F++S ++++ V+G+
Sbjct: 697 NFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQGKYLLNGHFVVSAVERDLVVKGS- 755
Query: 794 TVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTW--D 851
++ YSG+ AVE + ++ + L ++VL VG + P V YSF +P E R D + D
Sbjct: 756 -LLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKSSHPKD 814
Query: 852 PYGPWEGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVI 911
P GP + +H S S+ + E P+ RW
Sbjct: 815 PRGP----------------SVLHNSVLSLSNQVEQPDDRPPA------------RWVAG 846
Query: 912 GKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWH 971
CS+ CG G + + C G Q C +P + C C W
Sbjct: 847 SWGPCSASCGSGLQKRAVDC------RGSAGQRTVPACDAAHRPVETQACGEPC--PTWE 898
Query: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNEC 1006
S WS CS+SCG G + R C+ + G LA ++C
Sbjct: 899 LSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQC 933
Score = 102 bits (255), Expect = 3e-21
Identities = 55/149 (36%), Positives = 76/149 (51%), Gaps = 8/149 (5%)
Query: 1268 SHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHR 1327
S P P PS ++ L L+ ++E +++ P R W G WG CS+SC GLQ R
Sbjct: 809 SSHPKDPRGPSVLHNSVLSLSNQVEQPDDR---PPAR---WVAGSWGPCSASCGSGLQKR 862
Query: 1328 AVVCQDENGQ-SASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQ 1386
AV C+ GQ + CDAA +P E Q CG PCP W W CS++CG G + R + C
Sbjct: 863 AVDCRGSAGQRTVPACDAAHRPVETQACGE-PCPTWELSAWSPCSKSCGRGFQRRSLKCV 921
Query: 1387 FPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
G++L C + KP + C + C
Sbjct: 922 GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 82.0 bits (201), Expect = 5e-15
Identities = 34/110 (30%), Positives = 56/110 (50%), Gaps = 2/110 (1%)
Query: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGP 1084
W A W C +CG G ++R V C+ + + C+++ +P C C +W++
Sbjct: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCPTWELSA 901
Query: 1085 WGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
W PC+ +CG G+Q R +KCV +L +C+ +P + CVL PC
Sbjct: 902 WSPCSKSCGRGFQRRSLKCVGH-GGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 80.9 bits (198), Expect = 1e-14
Identities = 44/112 (39%), Positives = 54/112 (48%), Gaps = 4/112 (3%)
Query: 1154 AQWRHGSWTPCSVSCGRGTQARYVSCR-DALDRIADESYCAHLPRPAEIWDCFTPCGEWQ 1212
A+W GSW PCS SCG G Q R V CR A R AH RP E C PC W+
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAH--RPVETQACGEPCPTWE 898
Query: 1213 AGDWSPCSASCGHGKTTRQVLCMNY-HQPIDENYCDPEVRPLMEQECSLAAC 1263
WSPCS SCG G R + C+ + + + + C+ +P C L C
Sbjct: 899 LSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 73.2 bits (178), Expect = 2e-12
Identities = 41/138 (29%), Positives = 63/138 (45%), Gaps = 5/138 (3%)
Query: 1332 QDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQ 1391
+D G S + S +++Q P +W G+WG CS +CG G++ R V C+ GQ
Sbjct: 813 KDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQ 872
Query: 1392 ILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRK 1451
C+ ++P C CP +W W+ CS SCG+G + R + C+ R
Sbjct: 873 RTVPA-CDAAHRPVETQACG-EPCP---TWELSAWSPCSKSCGRGFQRRSLKCVGHGGRL 927
Query: 1452 LEDTNCSQVQKPPTHKAC 1469
L C+ +KP C
Sbjct: 928 LARDQCNLHRKPQELDFC 945
Score = 71.2 bits (173), Expect = 9e-12
Identities = 44/132 (33%), Positives = 55/132 (41%), Gaps = 23/132 (17%)
Query: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFI 1137
A W G WGPC+ +CG G Q R V C + C A RP + Q+C PC
Sbjct: 841 ARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTV--PACDAAHRPVETQACG-EPC--- 894
Query: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPR 1197
PT W +W+PCS SCGRG Q R + C R+ C +
Sbjct: 895 --------PT--------WELSAWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRK 938
Query: 1198 PAEIWDC-FTPC 1208
P E+ C PC
Sbjct: 939 PQELDFCVLRPC 950
Score = 69.7 bits (169), Expect = 3e-11
Identities = 41/114 (35%), Positives = 52/114 (45%), Gaps = 10/114 (8%)
Query: 969 RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSR-VTRENCNEFSCPSWAA 1027
RW W CS SCG G + R C + G R C R V + C E CP+W
Sbjct: 842 RWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVP-ACDAAHRPVETQACGE-PCPTWEL 899
Query: 1028 SEWSECLVTCGKGTKQRQVWCQLNVDH----LSDGFCNSSTKPESLSPCELHTC 1077
S WS C +CG+G ++R + C V H L+ CN KP+ L C L C
Sbjct: 900 SAWSPCSKSCGRGFQRRSLKC---VGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 65.1 bits (157), Expect = 6e-10
Identities = 33/110 (30%), Positives = 51/110 (46%), Gaps = 2/110 (1%)
Query: 1421 WHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKAN 1480
W W CSASCG G + R V C ++ C +P +AC CP+W+ +
Sbjct: 843 WVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA-CDAAHRPVETQACGEP-CPTWELS 900
Query: 1481 SWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
+W+ CS +CG G Q+R + C G + + C+ +P C + C
Sbjct: 901 AWSPCSKSCGRGFQRRSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 63.2 bits (152), Expect = 2e-09
Identities = 43/155 (27%), Positives = 49/155 (31%), Gaps = 45/155 (29%)
Query: 1207 PCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPA 1266
P W AG W PCSASCG G R V C CD RP+ Q C CP
Sbjct: 839 PPARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCP-- 895
Query: 1267 HSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQH 1326
W W CS SC G Q
Sbjct: 896 ----------------------------------------TWELSAWSPCSKSCGRGFQR 915
Query: 1327 RAVVCQDENGQ--SASYCDAASKPPELQQCGPGPC 1359
R++ C G+ + C+ KP EL C PC
Sbjct: 916 RSLKCVGHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 47.4 bits (111), Expect = 1e-04
Identities = 39/149 (26%), Positives = 60/149 (40%), Gaps = 27/149 (18%)
Query: 1570 VYNSSTISLTSKNCR---NPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKK--- 1623
V ++S +SL+++ + PP + V C+ +CG ++R C +
Sbjct: 820 VLHNSVLSLSNQVEQPDDRPPARW--VAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPA 877
Query: 1624 -HKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCI 1682
HR P+ Q C C TW++ WS CS +CG G +R +KC+
Sbjct: 878 CDAAHR--PVETQACG-----------EPC---PTWELSAWSPCSKSCGRGFQRRSLKCV 921
Query: 1683 TKHG--LSSDLCLNHLKPGAQKKCYANDC 1709
G L+ D C H KP C C
Sbjct: 922 GHGGRLLARDQCNLHRKPQELDFCVLRPC 950
Score = 34.3 bits (77), Expect = 1.2
Identities = 85/349 (24%), Positives = 117/349 (33%), Gaps = 102/349 (29%)
Query: 1212 QAGDWSPCSASC-------GHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACP 1264
+A WS CSA+ GHG L +PI P + Q+C LA
Sbjct: 399 RANPWSACSAAIITDFLDSGHG----DCLLDQPSKPISLPEDLPGASYTLSQQCELAF-- 452
Query: 1265 PAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGL 1324
S P P T L T K + Q+V Q R PW +SC G
Sbjct: 453 ----GVGSKPC-PYMQYCTKLWCTGKAK---GQMVC------QTRHFPWAD-GTSCGEGK 497
Query: 1325 QHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVI 1384
C + + + D G +W+ +G CS+TCGGG++
Sbjct: 498 LCLKGACVERHNLNKHRVD-------------GSWAKWD--PYGPCSRTCGGGVQLARRQ 542
Query: 1385 CQFP---NGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYRE 1441
C P NG CE V C++ CP+ S G+ +RE
Sbjct: 543 CTNPTPANG----GKYCEGVR--VKYRSCNLEPCPSSAS---------------GKSFRE 581
Query: 1442 VFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRD---V 1498
C + F TN R +W V SGV RD +
Sbjct: 582 EQC-EAFNGYNHSTN-------------RLTLAVAW---------VPKYSGVSPRDKCKL 618
Query: 1499 YCRLKGVG-------QVVE-EMCD-QSTRPCSQRRCWSQDCVQHKGMER 1538
CR G G +VV+ +C ST C Q +C C + G ++
Sbjct: 619 ICRANGTGYFYVLAPKVVDGTLCSPDSTSVCVQGKCIKAGCDGNLGSKK 667
Score = 33.5 bits (75), Expect = 2.0
Identities = 21/57 (36%), Positives = 27/57 (47%), Gaps = 6/57 (10%)
Query: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
A W P+GPC+ TCG G Q+ +C N + + E R R SC L PC
Sbjct: 520 AKWD--PYGPCSRTCGGGVQLARRQCTNPTPA---NGGKYCEGVRVKYR-SCNLEPC 570
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 639 bits (1648), Expect = 0.0
Identities = 351/908 (38%), Positives = 501/908 (55%), Gaps = 56/908 (6%)
Query: 78 THYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNS 137
T R A+ Q L L D+SFLA G+T ++G + E+ +DL HCFY G VN
Sbjct: 74 TRLRLHAFDQQLDLELRPDSSFLAPGFTLQNVG--RKSGSETPLPETDLAHCFYSGTVNG 131
Query: 138 QEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGN--EYEDGHNKP-----HLIYRQ-- 188
A +SLC G+ G F YF++P+ A G P HL+ R
Sbjct: 132 DPSSAAALSLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQ 191
Query: 189 -DLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERR 247
D+ + C V + + + T +ED E S P
Sbjct: 192 GDVGGT-------CGVVDDEPRPTGKA----ETEDEDEGTEGEDEGAQWSPQDPALQGVG 240
Query: 248 HS------RKKRLISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGN 301
RKKR +S RY+E M+ AD + HGS L++Y+LTL S+ A +YK PSI N
Sbjct: 241 QPTGTGSIRKKRFVSSHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRN 300
Query: 302 LIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITRED 361
+ +VVVK+++IH E++GP + + A TL+NFC+WQ+ N D H+DTA+L TR+D
Sbjct: 301 SVSLVVVKILVIHDEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQD 360
Query: 362 ICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKE 421
+C S + C+ LG++ +GT+CDP +SC + E+ GL +AFT AHELGH + HDD +C
Sbjct: 361 LCGS-QTCDTLGMADVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCAS 419
Query: 422 MKVTKY--HVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELP 479
+ H+MA LS WS CS +T FLD G+GECL+DKP I LP +LP
Sbjct: 420 LNGVNQDSHMMASMLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQNPI-QLPGDLP 478
Query: 480 GSRYDGNKQCELAFGPGSQMCPHI-NICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGM 538
G+ YD N+QC+ FG S+ CP + C LWCT T C T+H P ADGT CG G
Sbjct: 479 GTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGK 538
Query: 539 HCRHGLCVNKETETR---PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC 595
C +G CVNK P +G WG W P+ CSRTCGGG++ R C+ P P+NGG YC
Sbjct: 539 WCINGKCVNKTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYC 598
Query: 596 VGRRMKFRSCNTDSCPKGT-QDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRC 654
G+R+++RSCN + CP + FRE+QC N G V W+P+Y+G+ KDRC
Sbjct: 599 EGKRVRYRSCNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAVEWIPKYAGVSPKDRC 658
Query: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
KL CQ G YF++L+ V DGTPC ++ +CVQGQC+ AGCD +++S K DKCGVCG
Sbjct: 659 KLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCG 718
Query: 715 GDNSSCKTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDD-SYLALSDAEGNFL 773
G+ S+CK I+G S+ GY+ ++ IP GATN++++Q + G ++ S+LA+ A+G ++
Sbjct: 719 GNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAADGTYI 778
Query: 774 FNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDV 833
NG++ LST +++I +G V+ YSGS+ A+ERI S + ++ L +QVL VGN P +
Sbjct: 779 LNGDYTLSTLEQDIMYKG--VVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKI 836
Query: 834 HYSFNIPLEERS----DMFTWDPYGPWEGCTKMCQ-GLQRRNITCIHKSDHSVVSDKECD 888
Y++ + ++ S F+ W C+K C+ G QRR + C D + EC
Sbjct: 837 KYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVEC---RDINGQPASECA 893
Query: 889 HLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHY 948
P+ + C +W + S CS CG+GY+ + C+ H+G + H
Sbjct: 894 KEVKPASTRPCADHPCP-QWQLGEWSSCSKTCGKGYKKRSLKCLS---HDGGVL---SHE 946
Query: 949 CGDQLKPP 956
D LK P
Sbjct: 947 SCDPLKKP 954
Score = 102 bits (253), Expect = 5e-21
Identities = 47/109 (43%), Positives = 56/109 (51%), Gaps = 1/109 (0%)
Query: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNW 1367
W WG CS SC G Q R V C+D NGQ AS C KP + C PCPQW G W
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQWQLGEW 917
Query: 1368 GECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ-CHMHAC 1415
CS+TCG G K R + C +G +L +C+ + KP I C M C
Sbjct: 918 SSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 81.3 bits (199), Expect = 9e-15
Identities = 38/113 (33%), Positives = 54/113 (47%), Gaps = 3/113 (2%)
Query: 1024 SWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVG 1083
+W EW EC +C G ++R V C+ +++ C KP S PC H C WQ+G
Sbjct: 857 AWVIEEWGECSKSCELGWQRRLVECR-DINGQPASECAKEVKPASTRPCADHPCPQWQLG 915
Query: 1084 PWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCS 1135
W C+ TCG GY+ R +KC++ VL C +P C + CS
Sbjct: 916 EWSSCSKTCGKGYKKRSLKCLSH-DGGVLSHESCDPLKKPKHFIDFCTMAECS 967
Score = 74.3 bits (181), Expect = 1e-12
Identities = 42/117 (35%), Positives = 56/117 (47%), Gaps = 5/117 (4%)
Query: 1150 IKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFT-PC 1208
I + W W CS SC G Q R V CRD + A E CA +PA C PC
Sbjct: 852 IPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKPASTRPCADHPC 909
Query: 1209 GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPI-DENYCDPEVRPL-MEQECSLAAC 1263
+WQ G+WS CS +CG G R + C+++ + CDP +P C++A C
Sbjct: 910 PQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 71.2 bits (173), Expect = 9e-12
Identities = 37/119 (31%), Positives = 54/119 (45%), Gaps = 8/119 (6%)
Query: 1413 HACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSV 1472
+A P +W E W CS SC G + R V C D + + C++ KP + + C
Sbjct: 850 NAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKEVKPASTRPCADH 907
Query: 1473 RCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRP------CSQRRC 1525
CP W+ W+ CS TCG G ++R + C G + E CD +P C+ C
Sbjct: 908 PCPQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKPKHFIDFCTMAEC 966
Score = 67.0 bits (162), Expect = 2e-10
Identities = 40/116 (34%), Positives = 58/116 (50%), Gaps = 7/116 (6%)
Query: 967 FTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNEC-QELSRVTRENCNEFSCPSW 1025
F+ W EW +CS+SC G + R C + G + EC +E+ + C + CP W
Sbjct: 855 FSAWVIEEWGECSKSCELGWQRRLVECRDINGQPAS--ECAKEVKPASTRPCADHPCPQW 912
Query: 1026 AASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPES-LSPCELHTCA 1078
EWS C TCGKG K+R + C L+ D LS C+ KP+ + C + C+
Sbjct: 913 QLGEWSSCSKTCGKGYKKRSLKC-LSHDGGVLSHESCDPLKKPKHFIDFCTMAECS 967
Score = 59.3 bits (142), Expect = 3e-08
Identities = 33/131 (25%), Positives = 54/131 (41%), Gaps = 22/131 (16%)
Query: 1076 TCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCS 1135
T ++W + WG C+ +C G+Q R V+C + +EC + +P+ + C PC
Sbjct: 854 TFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPA---SECAKEVKPASTRPCADHPC- 909
Query: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHL 1195
QW+ G W+ CS +CG+G + R + C + C L
Sbjct: 910 ------------------PQWQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPL 951
Query: 1196 PRPAEIWDCFT 1206
+P D T
Sbjct: 952 KKPKHFIDFCT 962
Score = 53.5 bits (127), Expect = 2e-06
Identities = 39/161 (24%), Positives = 56/161 (34%), Gaps = 47/161 (29%)
Query: 1191 YCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYH-QPIDENYCDPE 1249
Y + + E ++ W +W CS SC G R V C + + QP E C E
Sbjct: 838 YTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDINGQPASE--CAKE 895
Query: 1250 VRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWR 1309
V+P + C+ CP QW+
Sbjct: 896 VKPASTRPCADHPCP------------------------------------------QWQ 913
Query: 1310 TGPWGSCSSSCSGGLQHRAVVCQDENGQSASY--CDAASKP 1348
G W SCS +C G + R++ C +G S+ CD KP
Sbjct: 914 LGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 52.0 bits (123), Expect = 6e-06
Identities = 32/111 (28%), Positives = 54/111 (48%), Gaps = 20/111 (18%)
Query: 1593 VTADSSQCANNCGFSYRQRITYCTEI---PSTKKHKLHRLRPIVYQECPVVPSSQVYQCI 1649
V + +C+ +C +++R+ C +I P+++ K ++P + C P Q
Sbjct: 859 VIEEWGECSKSCELGWQRRLVECRDINGQPASECAK--EVKPASTRPCADHPCPQ----- 911
Query: 1650 NSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHG--LSSDLCLNHLKP 1698
W++G+WS CS TCG G KR +KC++ G LS + C KP
Sbjct: 912 --------WQLGEWSSCSKTCGKGYKKRSLKCLSHDGGVLSHESCDPLKKP 954
Score = 47.4 bits (111), Expect = 1e-04
Identities = 96/504 (19%), Positives = 177/504 (35%), Gaps = 106/504 (21%)
Query: 1294 NENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQ 1353
N++ + S+ N + PW CS+ + +NG D P +L
Sbjct: 424 NQDSHMMASMLSNLDHSQPWSPCSAYM--------ITSFLDNGHGECLMDKPQNPIQL-- 473
Query: 1354 CGPGPCPQWNYGNWGECSQTCGG------------------GIKSRLVICQFPNGQILED 1395
PG P +Y +C T G G +++CQ + +
Sbjct: 474 --PGDLPGTSYDANRQCQFTFGEDSKHCPDAASTCSTLWCTGTSGGVLVCQTKHFPWADG 531
Query: 1396 HNC---------EIVNKPPSVIQCHMHACPADVSWHQ-EPWTSCSASCGKGRKYREVFCI 1445
+C + VNK + H P SW PW CS +CG G +Y C
Sbjct: 532 TSCGEGKWCINGKCVNKTD---RKHFDT-PFHGSWGMWGPWGDCSRTCGGGVQYTMRECD 587
Query: 1446 DQFQR---------KLEDTNCSQVQKPPTH-KACRSVRCPSWKANSWNECSVTCG----- 1490
+ + ++ +C+ P + K R +C + N +++ S G
Sbjct: 588 NPVPKNGGKYCEGKRVRYRSCNLEDCPDNNGKTFREEQCEAH--NEFSKASFGSGPAVEW 645
Query: 1491 ----SGVQQRD---VYCRLKGVG-------QVVE--EMCDQSTRPCSQRRCWSQDCVQHK 1534
+GV +D + C+ KG+G +VV+ ST C Q +C C +
Sbjct: 646 IPKYAGVSPKDRCKLICQAKGIGYFFVLQPKVVDGTPCSPDSTSVCVQGQCVKAGCDRII 705
Query: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIR----QVNEIVYNSSTISLTSKNCRNPPCN- 1589
++ C + +++ + + + I ++ I + +N R N
Sbjct: 706 DSKKKFDKCGVCGGNGSTCKKISGSVTSAKPGYHDIITIPTGATNIEVKQRNQRGSRNNG 765
Query: 1590 -YIVVTADSSQCANNCGFSY---RQRITYCTEIP--STKKHKLHRLR-------PIVYQE 1636
++ + A N ++ Q I Y + S L R+R P+ Q
Sbjct: 766 SFLAIKAADGTYILNGDYTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQV 825
Query: 1637 CPVVPS-----------SQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKH 1685
V + + + N+ + W + +W +CS +C +G +R V+C +
Sbjct: 826 LTVGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEWGECSKSCELGWQRRLVECRDIN 885
Query: 1686 GLSSDLCLNHLKPGAQKKCYANDC 1709
G + C +KP + + C + C
Sbjct: 886 GQPASECAKEVKPASTRPCADHPC 909
Score = 36.2 bits (82), Expect = 0.32
Identities = 46/197 (23%), Positives = 67/197 (34%), Gaps = 40/197 (20%)
Query: 1084 PWGPCTTTC-------GHGYQMRD-----VKCVNELASAVLEDTECHEASRPSDRQSCVL 1131
PW PC+ GHG + D ++ +L + + + D + C
Sbjct: 442 PWSPCSAYMITSFLDNGHGECLMDKPQNPIQLPGDLPGTSYDANRQCQFTFGEDSKHCPD 501
Query: 1132 TPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESY 1191
+ + T VL+ Q +H W SCG G C + DR
Sbjct: 502 AASTCSTLWCTGTSGGVLV---CQTKHFPWAD-GTSCGEGKWCINGKCVNKTDR------ 551
Query: 1192 CAHLPRPAEIWDCFTPCGEWQA-GDWSPCSASCGHGKTTRQVLCMNYHQPIDEN---YCD 1247
H P G W G W CS +CG G C N P+ +N YC
Sbjct: 552 -KHFDTPFH--------GSWGMWGPWGDCSRTCGGGVQYTMRECDN---PVPKNGGKYC- 598
Query: 1248 PEVRPLMEQECSLAACP 1264
E + + + C+L CP
Sbjct: 599 -EGKRVRYRSCNLEDCP 614
Score = 33.1 bits (74), Expect = 2.7
Identities = 21/70 (30%), Positives = 29/70 (41%), Gaps = 14/70 (20%)
Query: 1036 TCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHG 1095
+CG+G WC +G C + T + + W GPWG C+ TCG G
Sbjct: 533 SCGEGK-----WC-------INGKCVNKTDRKHFDTPFHGSWGMW--GPWGDCSRTCGGG 578
Query: 1096 YQMRDVKCVN 1105
Q +C N
Sbjct: 579 VQYTMRECDN 588
Score = 32.7 bits (73), Expect = 3.5
Identities = 20/73 (27%), Positives = 32/73 (43%), Gaps = 3/73 (4%)
Query: 1543 CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCAN 1602
CS SCE + +EC D + +E S ++ C + PC + + S C+
Sbjct: 866 CSKSCELGWQRRLVECRDINGQPASECAKEVKPAS--TRPCADHPCPQWQL-GEWSSCSK 922
Query: 1603 NCGFSYRQRITYC 1615
CG Y++R C
Sbjct: 923 TCGKGYKKRSLKC 935
Score = 31.6 bits (70), Expect = 7.8
Identities = 17/52 (32%), Positives = 22/52 (42%), Gaps = 2/52 (3%)
Query: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCP 1023
+ W CSR+CGGG + C N + E RV +CN CP
Sbjct: 565 WGPWGDCSRTCGGGVQYTMRECDNPVPKN--GGKYCEGKRVRYRSCNLEDCP 614
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 613 bits (1580), Expect = e-175
Identities = 375/1113 (33%), Positives = 579/1113 (52%), Gaps = 93/1113 (8%)
Query: 6 WLTGLLYHLSLFITRSWEVDFHP-------RQEALVRTLTSYEVVIPERVNEFGEVFP-- 56
W T L + LSL + S +FH QE + L Y++ IP RV++ G
Sbjct: 5 WKT-LTWILSLIMASS---EFHSDHRLSYSSQEEFLTYLEHYQLTIPIRVDQNGAFLSFT 60
Query: 57 -QSHHFSRQKRSSEALEPMPF--RTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPE 113
++ SR++RS + ++P + ++ +AYG+ F LNLT + F++ +T + G +
Sbjct: 61 VKNDKHSRRRRSMDPIDPQQAVSKLFFKLSAYGKHFHLNLTLNTDFVSKHFTVEYWGK-D 119
Query: 114 RGAWESDAGPSDLRHCFYRGQVNSQEDY-KAVVSLCGGLTGTFKGQNGEYFLEPIMKADG 172
W+ D L +C Y G + Q K +S C GL G ++ EYF+EP+
Sbjct: 120 GPQWKHDF----LDNCHYTGYLQDQRSTTKVALSNCVGLHGVIATEDEEYFIEPLKNTTE 175
Query: 173 NE----YEDGHNKPHLIYRQD-LNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNV 227
+ YE+GH PH+IY++ L L +C VS+ + P+ +N+ V
Sbjct: 176 DSKHFSYENGH--PHVIYKKSALQQRHLYDHSHCGVSD--FTRSGKPWW----LNDTSTV 227
Query: 228 MKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHG-SNLQNYILTL 286
S ++P+ + H R+KR +S R++E +V AD +V HG ++++YIL++
Sbjct: 228 ---------SYSLPINNTHIHHRQKRSVSIERFVETLVVADKMMVGYHGRKDIEHYILSV 278
Query: 287 MSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQT------- 339
M+IVA +Y+D S+GN+++I+V +L+++ ++ IN +L +FC WQ++
Sbjct: 279 MNIVAKLYRDSSLGNVVNIIVARLIVLTEDQPNLEINHHADKSLDSFCKWQKSILSHQSD 338
Query: 340 QNDLDDVHPSHHDTAVLITREDICSSKEK-CNMLGLSYLGTICDPLQSCFINEEKGLISA 398
N + + +HHD AVLITR DIC+ K K C LGL+ + +C+P +SC INE+ GL SA
Sbjct: 339 GNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEPERSCSINEDIGLGSA 398
Query: 399 FTIAHELGHTLGVQHDD-NPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDT 457
FTIAHE+GH G+ HD C +MA ++ + +P+SWS CSR Y+T FLD+
Sbjct: 399 FTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFSWSACSRDYITSFLDS 458
Query: 458 GYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKL 517
G G CL ++P + + P+ PG YD ++QC +G S+ C + +C LWC S
Sbjct: 459 GRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQCKYGEVCRELWCLSKSNR 518
Query: 518 HKGCFTQHVPPADGTDCGPGM----HCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCG 573
C T +P A+GT C G C G CV T + ++G WGPW + CSRTCG
Sbjct: 519 ---CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSIDGGWGPWSLWGECSRTCG 575
Query: 574 GGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDIS 633
GG+ S+ R C+ P P GG YC+G R ++RSCNTD CP G++DFREKQC+DF+ ++
Sbjct: 576 GGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRDFREKQCADFD--NMPFR 633
Query: 634 GIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCM 693
G N W P Y+G G K C L C G N++ V DGT C ++ DIC+ G+C
Sbjct: 634 GKYYN--WKP-YTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCNADSLDICINGECK 689
Query: 694 AAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSS--HYGYNVVVKIPAGATNVDIRQ 751
GCD++L S A+ D+C VCGGD S+C I G FN S GY VV+IP G+ ++++R+
Sbjct: 690 HVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEVVQIPRGSVHIEVRE 749
Query: 752 YSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINST 811
+ S +Y+AL ++ NG + + +K +V G T Y + E + +
Sbjct: 750 VAMS----KNYIALKSEGDDYYINGAWTIDWPRK-FDVAG--TAFHYKRPTDEPESLEAL 802
Query: 812 NRQEKELILQVLCVGNLYNPDVHYSFNIPLE-----ERSDMFTWDPYGPWEGCTKMCQ-G 865
+ LI+ VL N + Y FN+P+ + FTW+ + PW C+ C G
Sbjct: 803 GPTSENLIVMVLL--QEQNLGIRYKFNVPITRTGSGDNEVGFTWN-HQPWSECSATCAGG 859
Query: 866 LQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGY 924
+QR+ + C D+S+V + CD P ++CNT+ C W + ECS C G
Sbjct: 860 VQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGM 919
Query: 925 RTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGG 984
RT + C++ I + +D C +P +E C+ +W +WS+C+ CG
Sbjct: 920 RTRAVLCIR-KIGPSEEETLDYSGCLTH-RPVEKEPCNNQSCPPQWVALDWSECTPKCGP 977
Query: 985 GERSRESYC-MNNFGHRLADNECQELSR-VTRENCNEFSC--PSWAASEWSECLVTCGKG 1040
G + R C ++ +C E S+ R C+ C P W +W +C CG G
Sbjct: 978 GFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLG 1037
Query: 1041 TKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCE 1073
+ R V C L+ + C + +P S+ CE
Sbjct: 1038 QQMRTVQC-LSYTGQASSDCLETVRPPSMQQCE 1069
Score = 157 bits (396), Expect = 1e-37
Identities = 89/256 (34%), Positives = 131/256 (51%), Gaps = 22/256 (8%)
Query: 1284 NLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ---DENGQSAS 1340
N+P+T + +N+V G W PW CS++C+GG+Q + VVC+ D + +
Sbjct: 827 NVPIT-RTGSGDNEV------GFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNN 879
Query: 1341 YCDAASKPPELQQ-CGPGPCP-QWNYGNWGECSQTCGGGIKSRLVIC---QFPNGQILED 1395
YCD SKPPE Q+ C PCP +W G+W ECS+TC GG+++R V+C P+ + D
Sbjct: 880 YCDPDSKPPENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLD 939
Query: 1396 HNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFC-IDQFQRKLED 1454
++ + ++P C+ +CP W W+ C+ CG G K+R V C +
Sbjct: 940 YSGCLTHRPVEKEPCNNQSCPP--QWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPA 997
Query: 1455 TNCSQVQKPPTHKACRSVRC--PSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEM 1512
C + KPP C RC P W W +CS CG G Q R V C L GQ +
Sbjct: 998 AQCPEESKPPVRIRCSLGRCPPPRWVTGDWGQCSAQCGLGQQMRTVQC-LSYTGQASSD- 1055
Query: 1513 CDQSTRPCSQRRCWSQ 1528
C ++ RP S ++C S+
Sbjct: 1056 CLETVRPPSMQQCESK 1071
Score = 112 bits (279), Expect = 5e-24
Identities = 79/241 (32%), Positives = 102/241 (42%), Gaps = 27/241 (11%)
Query: 1156 WRHGSWTPCSVSCGRGTQARYVSCRDALDR-IADESYCAHLPRPAEIWD-CFT-PCG-EW 1211
W H W+ CS +C G Q + V C+ D I +YC +P E C T PC EW
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPEW 903
Query: 1212 QAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEV----RPLMEQECSLAACPPAH 1267
GDW CS +C G TR VLC+ P +E D RP+ ++ C+ +CPP
Sbjct: 904 FIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQW 963
Query: 1268 SHFPSSPVQP--------------SYYLSTNLPLTQKLEDNENQVVHPSVRGN----QWR 1309
S P S LS P Q E+++ V G +W
Sbjct: 964 VALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWV 1023
Query: 1310 TGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGE 1369
TG WG CS+ C G Q R V C GQ++S C +PP +QQC C N E
Sbjct: 1024 TGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQC-ESKCDSTPISNTEE 1082
Query: 1370 C 1370
C
Sbjct: 1083 C 1083
Score = 110 bits (275), Expect = 1e-23
Identities = 73/274 (26%), Positives = 102/274 (37%), Gaps = 28/274 (10%)
Query: 955 PPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTR 1014
P T+ N V W++ WS+CS +C GG + +E C + + N +
Sbjct: 829 PITRTGSGDNEVGFTWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPP 888
Query: 1015 EN---CNEFSCP-SWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSST----KP 1066
EN CN CP W +W EC TC G + R V C + + + S +P
Sbjct: 889 ENQRACNTEPCPPEWFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRP 948
Query: 1067 ESLSPCELHTCA-SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD 1125
PC +C W W CT CG G++ R V C + S +C E S+P
Sbjct: 949 VEKEPCNNQSCPPQWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPV 1008
Query: 1126 RQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDR 1185
R C L C +W G W CS CG G Q R V C +
Sbjct: 1009 RIRCSLGRC-----------------PPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQ 1051
Query: 1186 IADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPC 1219
+ + C RP + C + C + C
Sbjct: 1052 ASSD--CLETVRPPSMQQCESKCDSTPISNTEEC 1083
Score = 105 bits (261), Expect = 6e-22
Identities = 67/261 (25%), Positives = 110/261 (42%), Gaps = 19/261 (7%)
Query: 1362 WNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVNKPP-SVIQCHMHACPADV 1419
WN+ W ECS TC GG++ + V+C + + I++++ C+ +KPP + C+ CP +
Sbjct: 844 WNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPE- 902
Query: 1420 SWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT---NCSQVQKPPTHKACRSVRC-P 1475
W W CS +C G + R V CI + E+T + +P + C + C P
Sbjct: 903 -WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPP 961
Query: 1476 SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVV-EEMCDQSTRPCSQRRCWSQDCVQHK 1534
W A W+EC+ CG G + R V C+ + + C + ++P + RC C +
Sbjct: 962 QWVALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPR 1021
Query: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT 1594
+ CS C Q+R V + Y S + R P
Sbjct: 1022 WVTGDWGQCSAQCG----------LGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESK 1071
Query: 1595 ADSSQCANNCGFSYRQRITYC 1615
DS+ +N ++ YC
Sbjct: 1072 CDSTPISNTEECKDVNKVAYC 1092
Score = 95.9 bits (237), Expect = 3e-19
Identities = 63/252 (25%), Positives = 106/252 (42%), Gaps = 17/252 (6%)
Query: 1476 SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEE-MCDQSTRPCSQRRCWSQDCVQHK 1534
+W W+ECS TC GVQ+++V C+ +V+ CD ++P +R + + +
Sbjct: 843 TWNHQPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPCPPE 902
Query: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTIS---LTSKNCRNPPCNYI 1591
L CS +C+ + + C E + S ++ + + C N C
Sbjct: 903 WFIGDWLECSKTCDGGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQ 962
Query: 1592 VVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQV-YQCIN 1650
V D S+C CG ++ RI C K L + P +CP V +C
Sbjct: 963 WVALDWSECTPKCGPGFKHRIVLC------KSSDLSKTFPAA--QCPEESKPPVRIRCSL 1014
Query: 1651 SCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGA----QKKCYA 1706
W G W +CS CG+G R V+C++ G +S CL ++P + + KC +
Sbjct: 1015 GRCPPPRWVTGDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDS 1074
Query: 1707 NDCKSFTTCKEI 1718
+ CK++
Sbjct: 1075 TPISNTEECKDV 1086
Score = 38.1 bits (87), Expect = 0.083
Identities = 28/95 (29%), Positives = 40/95 (42%), Gaps = 19/95 (20%)
Query: 1313 WGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQ-------CGPGPC------ 1359
+G+ S C G R + C ++ + + A++ Q C G C
Sbjct: 494 YGATSRQCKYGEVCRELWCLSKSNRCVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTW 553
Query: 1360 PQ-----WN-YGNWGECSQTCGGGIKSRLVICQFP 1388
PQ W + WGECS+TCGGG+ S L C P
Sbjct: 554 PQSIDGGWGPWSLWGECSRTCGGGVSSSLRHCDSP 588
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 603 bits (1556), Expect = e-172
Identities = 330/823 (40%), Positives = 488/823 (59%), Gaps = 53/823 (6%)
Query: 83 TAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYK 142
+A+G+ F L L D SFLA + LG G+ + G LR CF+ G VN + +
Sbjct: 58 SAFGKGFVLRLAPDDSFLAPEFKIERLG----GSGRATGGERGLRGCFFSGTVNGEPESL 113
Query: 143 AVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCS 202
A VSLC GL+G+F E+ ++P A G+ + PH + R + + L
Sbjct: 114 AAVSLCRGLSGSFLLDGEEFTIQP-QGAGGSLAQ-----PHRLQRWGPAGA--RPLPRGP 165
Query: 203 VSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIE 262
E + E + + +E G + PL SR KR +S R++E
Sbjct: 166 EWEVETGEGQRQERGDHQEDSEEESQEEEAEGASEPPPPLGAT---SRTKRFVSEARFVE 222
Query: 263 IMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVI 322
++ ADA + + +G++LQN+ILTLMS+ A IYK PSI N I+++VVK++++ E+ GP +
Sbjct: 223 TLLVADASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEV 282
Query: 323 NFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICD 382
+ +G TL+NFC+WQ+ N D HP H+DTA+L+TR++ C + C+ LG++ +GTICD
Sbjct: 283 SDNGGLTLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICD 342
Query: 383 PLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEM--KVTKYHVMAPALSFHMSP 440
P +SC + E++GL +A T+AHELGH L + HDD+ C + + K+HVMAP
Sbjct: 343 PNKSCSVIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQT 402
Query: 441 WSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPG--SRYDGNKQCELAFGPGSQ 498
WS CS Y+TE LD G+G+CLLD P + LP+ LPG + Y ++QC FGP +
Sbjct: 403 LPWSPCSAMYLTELLDGGHGDCLLDAPAAAL-PLPTGLPGRMALYQLDQQCRQIFGPDFR 461
Query: 499 MCPHI---NICMHLWCTSTEKLHKGCFTQH--VPPADGTDCGPGMHCRHGLCVNKETETR 553
CP+ ++C LWC T+ C T++ +P ADGT CGPG C G C+ +E R
Sbjct: 462 HCPNTSAQDVCAQLWC-HTDGAEPLCHTKNGSLPWADGTPCGPGHLCSEGSCLPEEEVER 520
Query: 554 P---VNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
P +G W PW P+ CSRTCGGG++ + R C PEP+NGG YC+GRR K++SC+T+ C
Sbjct: 521 PKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEEC 580
Query: 611 PKGTQDFREKQCSDFNG-KHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLL 669
P + FRE+QC +N + D+ G + ++W+P+Y+G+ +DRCKL+C+ G + F +
Sbjct: 581 PPDGKSFREQQCEKYNAYNYTDMDG--NLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVF 638
Query: 670 KDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNS 729
+ V DGT CG ET ICV+GQC+ AGCDHV++S K+DKCGVCGG +SC+ ++G
Sbjct: 639 EAKVIDGTLCGPETLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLTP 698
Query: 730 SHYGYNVVVKIPAGATNVDIRQYSYSG-QPDDSYLALSDAEGNFLFNGNFLLSTSKKEIN 788
++YGYN +V IPAGATN+D++Q S+ G Q D +YLAL A+G +L NGN +S +++I
Sbjct: 699 TNYGYNDIVTIPAGATNIDVKQRSHPGVQNDGNYLALKTADGQYLLNGNLAISAIEQDIL 758
Query: 789 VQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCV-GNLYNPDVHYSFNIP------- 840
V+G T+++YSGS +ER+ S + L +Q+L V G ++ P V Y+F +P
Sbjct: 759 VKG--TILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPNDVDFSM 816
Query: 841 --LEERSDMFTWDP-------YGPWEGCTKMC-QGLQRRNITC 873
+ER+ P G W C+ C G QRR + C
Sbjct: 817 QSSKERATTNIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVEC 859
Score = 58.2 bits (139), Expect = 8e-08
Identities = 23/54 (42%), Positives = 32/54 (59%)
Query: 1307 QWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCP 1360
QW G W CSS+C G Q R V C+D +GQ+++ C+ A KP + + C CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
Score = 51.2 bits (121), Expect = 9e-06
Identities = 26/61 (42%), Positives = 32/61 (52%), Gaps = 1/61 (1%)
Query: 1649 INSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYAND 1708
I LH A W +G WS+CS TCG G +R V+C G +S C LKP K C +
Sbjct: 828 IQPLLH-AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQL 886
Query: 1709 C 1709
C
Sbjct: 887 C 887
Score = 50.4 bits (119), Expect = 2e-05
Identities = 23/56 (41%), Positives = 27/56 (48%), Gaps = 2/56 (3%)
Query: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACP 1416
QW G+W ECS TCG G + R V C+ P+GQ C KP C CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPEDAKPCESQLCP 888
Score = 49.7 bits (117), Expect = 3e-05
Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 1/53 (1%)
Query: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
W +WSEC TCG G ++R V C+ + + CN + KPE PCE C
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECR-DPSGQASATCNKALKPEDAKPCESQLC 887
Score = 46.6 bits (109), Expect = 2e-04
Identities = 20/57 (35%), Positives = 30/57 (52%), Gaps = 3/57 (5%)
Query: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
A W +G W C++TCG G+Q R V+C + A C++A +P D + C C
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRDPSGQA---SATCNKALKPEDAKPCESQLC 887
Score = 43.5 bits (101), Expect = 0.002
Identities = 22/54 (40%), Positives = 30/54 (55%), Gaps = 2/54 (3%)
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
W W+ECS TCG+G Q+R V CR GQ C+++ +P + C SQ C
Sbjct: 836 WVLGDWSECSSTCGAGWQRRTVECR-DPSGQ-ASATCNKALKPEDAKPCESQLC 887
Score = 42.0 bits (97), Expect = 0.006
Identities = 25/80 (31%), Positives = 34/80 (42%), Gaps = 6/80 (7%)
Query: 1342 CDAASKPPELQQCGPGPCPQWNY---GNWGECSQTCGGGIKSRLVICQFPNGQILEDHNC 1398
C S PE + P P + G WGECS+TCGGG++ C+ P Q +
Sbjct: 507 CSEGSCLPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQ---NGGR 563
Query: 1399 EIVNKPPSVIQCHMHACPAD 1418
+ + CH CP D
Sbjct: 564 YCLGRRAKYQSCHTEECPPD 583
Score = 41.6 bits (96), Expect = 0.007
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 3/71 (4%)
Query: 1291 LEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSAS-YCDAASKPP 1349
L + E + P G GPWG CS +C GG+Q C+D Q+ YC +
Sbjct: 513 LPEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYC--LGRRA 570
Query: 1350 ELQQCGPGPCP 1360
+ Q C CP
Sbjct: 571 KYQSCHTEECP 581
Score = 41.6 bits (96), Expect = 0.007
Identities = 23/70 (32%), Positives = 33/70 (47%), Gaps = 7/70 (10%)
Query: 1406 SVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPT 1465
++IQ +HA W W+ CS++CG G + R V C D + C++ KP
Sbjct: 826 NIIQPLLHA-----QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPED 878
Query: 1466 HKACRSVRCP 1475
K C S CP
Sbjct: 879 AKPCESQLCP 888
Score = 40.0 bits (92), Expect = 0.022
Identities = 16/28 (57%), Positives = 18/28 (64%)
Query: 1154 AQWRHGSWTPCSVSCGRGTQARYVSCRD 1181
AQW G W+ CS +CG G Q R V CRD
Sbjct: 834 AQWVLGDWSECSSTCGAGWQRRTVECRD 861
Score = 39.3 bits (90), Expect = 0.037
Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 1/55 (1%)
Query: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACP 1264
+W GDWS CS++CG G R V C + C+ ++P + C CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQASAT-CNKALKPEDAKPCESQLCP 888
Score = 37.7 bits (86), Expect = 0.11
Identities = 28/107 (26%), Positives = 41/107 (38%), Gaps = 8/107 (7%)
Query: 1003 DNECQELSRVTRENCNEFSCPS-----WAASEWSECLVTCGKGTKQRQVWCQLNVDHL-S 1056
D +C+++ +C S W ++ +E L G+ HL S
Sbjct: 449 DQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEPLCHTKNGSLPWADGTPCGPGHLCS 508
Query: 1057 DGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKC 1103
+G C + E P A W GPWG C+ TCG G Q +C
Sbjct: 509 EGSCLPEEEVERPKPVADGGWAPW--GPWGECSRTCGGGVQFSHREC 553
Score = 35.4 bits (80), Expect = 0.54
Identities = 33/143 (23%), Positives = 50/143 (34%), Gaps = 26/143 (18%)
Query: 1425 PWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKA-NSWN 1483
PW CG G E C+ + +V++P + V W W
Sbjct: 494 PWAD-GTPCGPGHLCSEGSCLPE----------EEVERP------KPVADGGWAPWGPWG 536
Query: 1484 ECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNC 1543
ECS TCG GVQ C+ + R C RR Q C + G+
Sbjct: 537 ECSRTCGGGVQFSHRECK--------DPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFR 588
Query: 1544 STSCERKDSHQRMECTDNQIRQV 1566
CE+ +++ + N ++ V
Sbjct: 589 EQQCEKYNAYNYTDMDGNLLQWV 611
Score = 32.3 bits (72), Expect = 4.5
Identities = 17/56 (30%), Positives = 25/56 (44%), Gaps = 3/56 (5%)
Query: 969 RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQE-LSRVTRENCNEFSCP 1023
+W +WS+CS +CG G + R C + G A C + L + C CP
Sbjct: 835 QWVLGDWSECSSTCGAGWQRRTVECRDPSGQ--ASATCNKALKPEDAKPCESQLCP 888
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 580 bits (1496), Expect = e-165
Identities = 375/1098 (34%), Positives = 539/1098 (49%), Gaps = 77/1098 (7%)
Query: 3 VAKWLTGLLYHLSLFITRSWEVDFHPRQEALVRTLTSYEVVIPERVNEFGEVFPQSHHFS 62
+ +W L L +T ++ Q+ + +L SYE+ P RV+ G + S
Sbjct: 7 ILRWALALGLGLMFEVTHAFR-----SQDEFLSSLESYEIAFPTRVDHNGALLAFSPPPP 61
Query: 63 RQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAG 122
R++R R Y+ + F LNLT +S L AG+ V T E AW+ A
Sbjct: 62 RRQRRGTGATAES-RLFYKVASPSTHFLLNLTR-SSRLLAGHVSVEYWTREGLAWQRAAR 119
Query: 123 PSDLRHCFYRGQVNSQEDYKAV-VSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNK 181
P HC Y G + Q V +S CGGL G EY +EP+ +
Sbjct: 120 P----HCLYAGHLQGQASTSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESG 175
Query: 182 PHLIY-RQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNV 240
PH++Y R L + L T C V + + P+ L R LG+ +
Sbjct: 176 PHVVYKRSSLRHPHLDTA--CGVRDEK------PWKGRPWWLRTLKPPPARPLGNET--- 224
Query: 241 PLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSI 299
ER KR +S RY+E +V AD +V+ HG +++ Y+L +M+IVA +++D S+
Sbjct: 225 ----ERGQPGLKRSVSRERYVETLVVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSL 280
Query: 300 GNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQT-------QNDLDDVHPSHHD 352
G+ ++I+V +L+++ ++ I +L +FC WQ++ N + + ++HD
Sbjct: 281 GSTVNILVTRLILLTEDQPTLEITHHAGKSLDSFCKWQKSIVNHSGHGNAIPENGVANHD 340
Query: 353 TAVLITREDICSSKEK-CNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGV 411
TAVLITR DIC K K C LGL+ +G +C+ +SC +NE+ GL +AFTIAHE+GHT G+
Sbjct: 341 TAVLITRYDICIYKNKPCGTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGM 400
Query: 412 QHDD-NPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEE 470
HD C +MA ++ +P+ WS+CSR Y+T FLD+G G CL ++P +
Sbjct: 401 NHDGVGNSCGARGQDPAKLMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQ 460
Query: 471 IYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINICMHLWCTSTEKLHKGCFTQHVPPAD 530
+ P+ PG YD ++QC G S+ C + +C LWC S C T +P A+
Sbjct: 461 DFVYPTVAPGQAYDADEQCRFQHGVKSRQCKYGEVCSELWCLSKSNR---CITNSIPAAE 517
Query: 531 GTDCGPGM----HCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRP 586
GT C C +CV + V+G WGPW P+ CSRTCGGG+ S++R C+ P
Sbjct: 518 GTLCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSP 577
Query: 587 EPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYS 646
P GG YC+G R + RSCNTD CP G+QDFRE QCS+F+ I +W Y
Sbjct: 578 RPTIGGKYCLGERRRHRSCNTDDCPPGSQDFREVQCSEFD----SIPFRGKFYKW-KTYR 632
Query: 647 GIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAK 706
G G K C L C G N++ V DGTPC +T DICV G+C GCD VL S +
Sbjct: 633 GGGVK-ACSLTCLAEGFNFYTERAAAVVDGTPCRPDTVDICVSGECKHVGCDRVLGSDLR 691
Query: 707 IDKCGVCGGDNSSCKTITGVFN--SSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLA 764
DKC VCGGD S+C+TI GVF+ S GY VV IP G+ ++ I+ + S S+LA
Sbjct: 692 EDKCRVCGGDGSACETIEGVFSPASPGAGYEDVVWIPKGSVHIFIQDLNLS----LSHLA 747
Query: 765 LSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLC 824
L + + L G L + + + T + + V+ + + LI+ VL
Sbjct: 748 LKGDQESLLLEG---LPGTPQPHRLPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLA 804
Query: 825 VGNLYNPDVHYSFNIPLEERS-DMFTWDPYGPWEGCTKMCQ-GLQRRNITCIHKSDHSVV 882
L P + Y FN P+ S ++W Y PW C+ C G Q + + C ++ D S V
Sbjct: 805 RTEL--PALRYRFNAPIARDSLPPYSWH-YAPWTKCSAQCAGGSQVQAVECRNQLDSSAV 861
Query: 883 SDKECD-HLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQ 940
+ C H LP ++CNT+ C W V S CS C G R+ + C + + +
Sbjct: 862 APHYCSAHSKLPK-RQRACNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQR-RVSAAE 919
Query: 941 TVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHR 1000
+DD C Q +PP E CHG W +WS+C+ SCG G R R C + HR
Sbjct: 920 EKALDDSAC-PQPRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLC-KSADHR 977
Query: 1001 --LADNECQELSR-VTRENCNEFSCP--SWAASEWSECLVTCGKGTKQRQVWCQLNVDHL 1055
L C ++ CN CP W A EW EC CG G +QR V C +
Sbjct: 978 ATLPPAHCSPAAKPPATMRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA 1037
Query: 1056 SDGFCNSSTKPESLSPCE 1073
S C + +P + CE
Sbjct: 1038 SHE-CTEALRPPTTQQCE 1054
Score = 157 bits (398), Expect = 7e-38
Identities = 89/240 (37%), Positives = 120/240 (50%), Gaps = 17/240 (7%)
Query: 1298 VVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA---SYCDAASKPPELQQ- 1353
+ S+ W PW CS+ C+GG Q +AV C+++ SA YC A SK P+ Q+
Sbjct: 819 IARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRA 878
Query: 1354 CGPGPCP-QWNYGNWGECSQTCGGGIKSRLVICQ----FPNGQILEDHNCEIVNKPPSVI 1408
C PCP W GNW CS++C G++SR V+CQ + L+D C +PP +
Sbjct: 879 CNTEPCPPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP-QPRPPVLE 937
Query: 1409 QCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQR-KLEDTNCSQVQKPPTHK 1467
CH CP + W W+ C+ SCG G ++R V C R L +CS KPP
Sbjct: 938 ACHGPTCPPE--WAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPATM 995
Query: 1468 ACRSVRCP--SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRC 1525
C RCP W A W ECS CG G +QR V C GQ E C ++ RP + ++C
Sbjct: 996 RCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRC-TSHTGQASHE-CTEALRPPTTQQC 1053
Score = 134 bits (338), Expect = 7e-31
Identities = 79/233 (33%), Positives = 104/233 (44%), Gaps = 19/233 (8%)
Query: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLK-PPTQELCHGNCV 966
WH ++CS+QC G + + C ++ + V HYC K P Q C+
Sbjct: 829 WHYAPWTKCSAQCAGGSQVQAVECR----NQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 967 FTRWHYSEWSQCSRSCGGGERSRESYCMNNFG----HRLADNECQELSRVTRENCNEFSC 1022
W WS CSRSC G RSR C L D+ C + E C+ +C
Sbjct: 885 PPDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQPRPPVLEACHGPTC 944
Query: 1023 P-SWAASEWSECLVTCGKGTKQRQVWCQLNVDH---LSDGFCNSSTKPESLSPCELHTC- 1077
P WAA +WSEC +CG G + R V C+ + DH L C+ + KP + C L C
Sbjct: 945 PPEWAALDWSECTPSCGPGLRHRVVLCK-SADHRATLPPAHCSPAAKPPATMRCNLRRCP 1003
Query: 1078 -ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSC 1129
A W G WG C+ CG G + R V+C + A EC EA RP Q C
Sbjct: 1004 PARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQA---SHECTEALRPPTTQQC 1053
Score = 134 bits (337), Expect = 8e-31
Identities = 83/285 (29%), Positives = 117/285 (41%), Gaps = 68/285 (23%)
Query: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASR-PSDRQSCVLTPCSFI 1137
SW PW C+ C G Q++ V+C N+L S+ + C S+ P +++C PC
Sbjct: 828 SWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCP-- 885
Query: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRD----ALDRIADESYCA 1193
W G+W+ CS SC G ++R V C+ A ++ D+S C
Sbjct: 886 ----------------PDWVVGNWSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACP 929
Query: 1194 HLPRPAEIWDCFTPC--GEWQAGDWSPCSASCGHGKTTRQVLCMN--YHQPIDENYCDPE 1249
PRP + C P EW A DWS C+ SCG G R VLC + + + +C P
Sbjct: 930 Q-PRPPVLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPA 988
Query: 1250 VRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWR 1309
+P C+L CPPA +W
Sbjct: 989 AKPPATMRCNLRRCPPA----------------------------------------RWV 1008
Query: 1310 TGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQC 1354
G WG CS+ C G + R+V C GQ++ C A +PP QQC
Sbjct: 1009 AGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQC 1053
Score = 126 bits (316), Expect = 2e-28
Identities = 77/281 (27%), Positives = 118/281 (41%), Gaps = 57/281 (20%)
Query: 1207 PCGEWQAGDWSPCSASCGHGKTTRQVLCMNY--HQPIDENYCDPEVR-PLMEQECSLAAC 1263
P W W+ CSA C G + V C N + +YC + P ++ C+ C
Sbjct: 825 PPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPC 884
Query: 1264 PPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGG 1323
PP W G W CS SC G
Sbjct: 885 PP-----------------------------------------DWVVGNWSLCSRSCDAG 903
Query: 1324 LQHRAVVCQ------DENGQSASYCDAASKPPELQQC-GPGPCPQWNYGNWGECSQTCGG 1376
++ R+VVCQ +E S C +PP L+ C GP P+W +W EC+ +CG
Sbjct: 904 VRSRSVVCQRRVSAAEEKALDDSAC-PQPRPPVLEACHGPTCPPEWAALDWSECTPSCGP 962
Query: 1377 GIKSRLVICQFPNGQ-ILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGK 1435
G++ R+V+C+ + + L +C KPP+ ++C++ CP W W CSA CG
Sbjct: 963 GLRHRVVLCKSADHRATLPPAHCSPAAKPPATMRCNLRRCP-PARWVAGEWGECSAQCGV 1021
Query: 1436 GRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPS 1476
G++ R V C + + C++ +PPT + C + +C S
Sbjct: 1022 GQRQRSVRCTSHTGQASHE--CTEALRPPTTQQCEA-KCDS 1059
Score = 82.8 bits (203), Expect = 3e-15
Identities = 66/255 (25%), Positives = 97/255 (38%), Gaps = 22/255 (8%)
Query: 1476 SWKANSWNECSVTCGSGVQQRDVYCRLK-GVGQVVEEMCDQSTR-PCSQRRCWSQDCVQH 1533
SW W +CS C G Q + V CR + V C ++ P QR C ++ C
Sbjct: 828 SWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPPD 887
Query: 1534 KGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTS----KNCRNPPCN 1589
+ L CS SC+ + + C ++ E + S + C P C
Sbjct: 888 WVVGNWSL-CSRSCDAGVRSRSVVC-QRRVSAAEEKALDDSACPQPRPPVLEACHGPTCP 945
Query: 1590 YIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCI 1649
D S+C +CG R R+ C K HR P +C
Sbjct: 946 PEWAALDWSECTPSCGPGLRHRVVLC-------KSADHRATLPPAHCSPAAKPPATMRCN 998
Query: 1650 NSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
A W G+W +CS CG+G +R V+C + G +S C L+P ++C A C
Sbjct: 999 LRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCEAK-C 1057
Query: 1710 KSFT------TCKEI 1718
S T CK++
Sbjct: 1058 DSPTPGDGPEECKDV 1072
Score = 56.2 bits (134), Expect = 3e-07
Identities = 36/113 (31%), Positives = 45/113 (39%), Gaps = 11/113 (9%)
Query: 856 WEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD-CE-LRWHVIG 912
W CT C GL+ R + C + + C P T CN C RW
Sbjct: 953 WSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPP-ATMRCNLRRCPPARWVAGE 1011
Query: 913 KSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNC 965
ECS+QCG G R + C H GQ H C + L+PPT + C C
Sbjct: 1012 WGECSAQCGVGQRQRSVRCTS---HTGQA----SHECTEALRPPTTQQCEAKC 1057
Score = 35.0 bits (79), Expect = 0.70
Identities = 25/83 (30%), Positives = 34/83 (40%), Gaps = 15/83 (18%)
Query: 1209 GEWQAGDWSP---CSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPP 1265
G W G W+P CS +CG G ++ C + I YC E R + C+ CPP
Sbjct: 548 GAW--GPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERR--RHRSCNTDDCPP 603
Query: 1266 AH--------SHFPSSPVQPSYY 1280
S F S P + +Y
Sbjct: 604 GSQDFREVQCSEFDSIPFRGKFY 626
Score = 34.7 bits (78), Expect = 0.92
Identities = 13/26 (50%), Positives = 16/26 (61%)
Query: 1367 WGECSQTCGGGIKSRLVICQFPNGQI 1392
WG+CS+TCGGG+ S C P I
Sbjct: 556 WGDCSRTCGGGVSSSSRHCDSPRPTI 581
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 556 bits (1432), Expect = e-158
Identities = 312/869 (35%), Positives = 458/869 (52%), Gaps = 56/869 (6%)
Query: 46 ERVNEFGEVFPQSHHFSRQKRSSEALEPMPF------RTHYRFTAYGQLFQLNLTADASF 99
E V E E H ++++RS ++ + + Y A G+ F L+L D S
Sbjct: 49 EEVQERAEPPGHPHPLAQRRRSKGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDGSV 108
Query: 100 LAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQN 159
AG+ GT W + HCFYRG V+ AV LCGGL G F ++
Sbjct: 109 GIAGFVPAGGGTS--APWRHRS------HCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKH 160
Query: 160 GEYFLEPIMKAD------GNEYEDGHNKP-HLIYRQDLNNSFLQTLKYCSVSESQIK-ET 211
Y L+P+++ G Y DG + H+ R+ + L C S +
Sbjct: 161 ARYTLKPLLRGPWAEEEKGRVYGDGSARILHVYTREGFSFEALPPRASCETPASTPEAHE 220
Query: 212 SLPFHTYSNMNEDL--NVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADA 269
P H+ + L ++ + L + P RR ++R IS R +E+++ ADA
Sbjct: 221 HAPAHSNPSGRAALASQLLDQSALSPAGGSGPQTWWRR---RRRSISRARQVELLLVADA 277
Query: 270 KVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATT 329
+ +G LQ+Y+LTL SI +Y SI N I + VVK+V++ +++ ++ + ATT
Sbjct: 278 SMARLYGRGLQHYLLTLASIANRLYSHASIENHIRLAVVKVVVLGDKDKSLEVSKNAATT 337
Query: 330 LKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFI 389
LKNFC WQ N L D H H+D A+L TRED+C C+ LG++ +GTIC P +SC +
Sbjct: 338 LKNFCKWQHQHNQLGDDHEEHYDAAILFTREDLCGH-HSCDTLGMADVGTICSPERSCAV 396
Query: 390 NEEKGLISAFTIAHELGHTLGVQHDDNPRCKEM--KVTKYHVMAPALSFHMSPWSWSNCS 447
E+ GL +AFT+AHE+GH LG+ HDD+ C+E +M+ L+ + WS C+
Sbjct: 397 IEDDGLHAAFTVAHEIGHLLGLSHDDSKFCEETFGSTEDKRLMSSILTSIDASKPWSKCT 456
Query: 448 RKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINICM 507
+TEFLD G+G CLLD P ++I P ELPG YD +QC L FGP +CP +++C
Sbjct: 457 SATITEFLDDGHGNCLLDLPRKQILG-PEELPGQTYDATQQCNLTFGPEYSVCPGMDVCA 515
Query: 508 HLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETE---TRPVNGEWGPWEP 564
LWC + C T+ +P +GT CG G C G CV+K + + +G WG W
Sbjct: 516 RLWCAVVRQGQMVCLTKKLPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGS 575
Query: 565 YSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSD 624
+ CSR+CGGG++ A R CN P PRN G YC G+R +RSC+ CP + FR +QC
Sbjct: 576 WGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEA 635
Query: 625 FNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETH 684
NG D G+ + V W+P+Y+G+ D CKL C+ GT Y+ + V DGT C ++
Sbjct: 636 KNGYQSDAKGVKTFVEWVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSN 695
Query: 685 DICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYGYNVVVKIPAGA 744
+CV+G+C+ GCD ++ S + DKCGVCGGDNSSC I G FN GY VV+IP GA
Sbjct: 696 SVCVRGKCVRTGCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSKGYTDVVRIPEGA 755
Query: 745 TNVDIRQYSYSGQPD-DSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNN 803
T++ +RQ+ Q +YLAL G +L NG +++STS+ I++ G TV+ YSG ++
Sbjct: 756 THIKVRQFKAKDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDING--TVMNYSGWSH 813
Query: 804 AVERINST--NRQEKELILQVLCVGNLYNPDVHYSFNIPLE-------------ERSDMF 848
+ ++ + ++ LI+Q+L DV YSF +P + +
Sbjct: 814 RDDFLHGMGYSATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSH 873
Query: 849 TWDPY---GPWEGCTKMCQ-GLQRRNITC 873
T P GPW C++ C G R + C
Sbjct: 874 TSQPQWVTGPWLACSRTCDTGWHTRTVQC 902
Score = 51.2 bits (121), Expect = 9e-06
Identities = 26/87 (29%), Positives = 38/87 (43%), Gaps = 3/87 (3%)
Query: 1271 PSSPVQPSYYL---STNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHR 1327
P+ P+ Y + P + + + V QW TGPW +CS +C G R
Sbjct: 839 PTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQWVTGPWLACSRTCDTGWHTR 898
Query: 1328 AVVCQDENGQSASYCDAASKPPELQQC 1354
V CQD N + A C + +P +QC
Sbjct: 899 TVQCQDGNRKLAKGCPLSQRPSAFKQC 925
Score = 42.0 bits (97), Expect = 0.006
Identities = 20/56 (35%), Positives = 29/56 (51%), Gaps = 2/56 (3%)
Query: 1360 PQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
PQW G W CS+TC G +R V CQ N ++ + C + +P + QC + C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAK--GCPLSQRPSAFKQCLLKKC 930
Score = 38.5 bits (88), Expect = 0.063
Identities = 20/58 (34%), Positives = 28/58 (48%), Gaps = 9/58 (15%)
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVN---ELASAVLEDTECHEASRPSDRQSCVLTPC 1134
W GPW C+ TC G+ R V+C + +LA C + RPS + C+L C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG------CPLSQRPSAFKQCLLKKC 930
Score = 37.7 bits (86), Expect = 0.11
Identities = 20/57 (35%), Positives = 23/57 (40%), Gaps = 1/57 (1%)
Query: 1021 SCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
S P W W C TC G R V CQ L+ G C S +P + C L C
Sbjct: 875 SQPQWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG-CPLSQRPSAFKQCLLKKC 930
Score = 37.4 bits (85), Expect = 0.14
Identities = 47/206 (22%), Positives = 69/206 (33%), Gaps = 41/206 (19%)
Query: 1349 PELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVI 1408
P Q GP P Y +C+ T G +C P + C +V + V
Sbjct: 476 PRKQILGPEELPGQTYDATQQCNLTFG----PEYSVC--PGMDVCARLWCAVVRQGQMV- 528
Query: 1409 QCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKA 1468
C PA CGKGR + C+D+ ++K T+
Sbjct: 529 -CLTKKLPAVEG----------TPCGKGRICLQGKCVDKTKKKYYSTSSHG--------- 568
Query: 1469 CRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQ 1528
SW SW +CS +CG GVQ +C + R C+ +R +
Sbjct: 569 ----NWGSW--GSWGQCSRSCGGGVQFAYRHCN--------NPAPRNNGRYCTGKRAIYR 614
Query: 1529 DCVQHKGMERGRLNCSTSCERKDSHQ 1554
C G+ CE K+ +Q
Sbjct: 615 SCSLMPCPPNGKSFRHEQCEAKNGYQ 640
Score = 37.0 bits (84), Expect = 0.18
Identities = 21/60 (35%), Positives = 26/60 (43%), Gaps = 3/60 (5%)
Query: 1302 SVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQ-SASYCDAASKPPELQQCGPGPCP 1360
S GN G WG CS SC GG+Q C + + + YC K + C PCP
Sbjct: 565 SSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYC--TGKRAIYRSCSLMPCP 622
Score = 36.6 bits (83), Expect = 0.24
Identities = 23/63 (36%), Positives = 28/63 (44%), Gaps = 8/63 (12%)
Query: 962 HGNCVFTRW-HYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEF 1020
HGN W + W QCSRSCGGG + +C NN R C R +C+
Sbjct: 567 HGN-----WGSWGSWGQCSRSCGGGVQFAYRHC-NNPAPRNNGRYCTG-KRAIYRSCSLM 619
Query: 1021 SCP 1023
CP
Sbjct: 620 PCP 622
Score = 36.2 bits (82), Expect = 0.32
Identities = 17/54 (31%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAAC 1263
+W G W CS +C G TR V C + ++ + + C RP ++C L C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKG-CPLSQRPSAFKQCLLKKC 930
Score = 35.8 bits (81), Expect = 0.41
Identities = 21/62 (33%), Positives = 25/62 (40%), Gaps = 4/62 (6%)
Query: 1209 GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHS 1268
G W G W CS SCG G C N + YC + + + CSL CPP
Sbjct: 571 GSW--GSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTG--KRAIYRSCSLMPCPPNGK 626
Query: 1269 HF 1270
F
Sbjct: 627 SF 628
Score = 35.4 bits (80), Expect = 0.54
Identities = 17/56 (30%), Positives = 26/56 (46%), Gaps = 2/56 (3%)
Query: 1475 PSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
P W W CS TC +G R V C + + + + C S RP + ++C + C
Sbjct: 877 PQWVTGPWLACSRTCDTGWHTRTVQC--QDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 35.4 bits (80), Expect = 0.54
Identities = 20/54 (37%), Positives = 24/54 (44%), Gaps = 2/54 (3%)
Query: 1421 WHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
W PW +CS +C G R V C D RKL C Q+P K C +C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDG-NRKLA-KGCPLSQRPSAFKQCLLKKC 930
Score = 34.7 bits (78), Expect = 0.92
Identities = 17/52 (32%), Positives = 22/52 (42%)
Query: 1658 WKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
W G W CS TC G R V+C + + C +P A K+C C
Sbjct: 879 WVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 34.3 bits (77), Expect = 1.2
Identities = 17/50 (34%), Positives = 22/50 (44%), Gaps = 2/50 (4%)
Query: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC 1204
QW G W CS +C G R V C+D ++A C RP+ C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLA--KGCPLSQRPSAFKQC 925
Score = 33.1 bits (74), Expect = 2.7
Identities = 22/77 (28%), Positives = 30/77 (38%), Gaps = 6/77 (7%)
Query: 1058 GFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTEC 1117
G C TK + S SW G WG C+ +CG G Q C N +
Sbjct: 551 GKCVDKTKKKYYSTSSHGNWGSW--GSWGQCSRSCGGGVQFAYRHCNNPAP----RNNGR 604
Query: 1118 HEASRPSDRQSCVLTPC 1134
+ + + +SC L PC
Sbjct: 605 YCTGKRAIYRSCSLMPC 621
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 550 bits (1418), Expect = e-156
Identities = 360/1130 (31%), Positives = 546/1130 (48%), Gaps = 100/1130 (8%)
Query: 40 YEVVIPERVNEFGEVFPQSH---HFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTAD 96
Y V P V+ G SH H R+KRS++ HYRF+A+GQ L L
Sbjct: 61 YVFVTPVEVDSAGSYI--SHDILHNGRKKRSAQNARSS---LHYRFSAFGQELHLELKPS 115
Query: 97 ASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFK 156
A L++ + LG + GA S+ +++ CFY+G + + VS C GL+G +
Sbjct: 116 A-ILSSHFIVQVLG--KDGA--SETQKPEVQQCFYQGFIRNDSSSSVAVSTCAGLSGLIR 170
Query: 157 GQNGEYFLEPIMKADGNEYE----DGHNKPHLIYRQDLNNSFLQTLKYCSVSESQ--IKE 210
+ E+ + P+ + E+ GH+ PH++Y++ + Y +
Sbjct: 171 TRKNEFLISPLPQLLAQEHNYSSPAGHH-PHVLYKRTAEEKIQRYRGYPGSGRNYPGYSP 229
Query: 211 TSLPFHTYSNMNE--DLNVMKERVLGHTSKNVPLK---------DERRHSRKKRLISYPR 259
+ +P + S E + K+ G K P DE S + R +
Sbjct: 230 SHIPHASQSRETEYHHRRLQKQHFCGRRKKYAPKPPTEDTYLRFDEYGSSGRPRRSAGKS 289
Query: 260 Y----IEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIH 314
+E +V AD K+V HG N+ YILT+M++V+ ++KD +IG+ I++VVV L+++
Sbjct: 290 QKGLNVETLVVADKKMVEKHGKGNVTTYILTVMNMVSGLFKDGTIGSDINVVVVSLILLE 349
Query: 315 REEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSK-EKCNMLG 373
+E G +IN +L +FC WQ L + HD A+L+T DICS K E C+ LG
Sbjct: 350 QEPGGLLINHHADQSLNSFCQWQSA---LIGKNGKRHDHAILLTGFDICSWKNEPCDTLG 406
Query: 374 LSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDD--NPRCKEMKVTKYHVMA 431
+ + +C +SC INE+ GL AFTIAHE GH G+ HD NP C++ + ++M+
Sbjct: 407 FAPISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNP-CRK---AEGNIMS 462
Query: 432 PALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEE-IYNLPSELPGSRYDGNKQCE 490
P L+ + +SWS+CSR+Y+ +FL T CL+D+P + Y P +LPG YD + QC+
Sbjct: 463 PTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCLVDEPKQAGQYKYPDKLPGQIYDADTQCK 522
Query: 491 LAFGPGSQMCPH---INICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVN 547
FG +++C +IC LWC ++ C T+ +P A+GT CG M CR G CV
Sbjct: 523 WQFGAKAKLCSLGFVKDICKSLWC---HRVGHRCETKFMPAAEGTVCGLSMWCRQGQCVK 579
Query: 548 -KETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCN 606
E RP++G+W W +S CSRTCGGG++ R CN P+P+ GG +C G ++ CN
Sbjct: 580 FGELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQYGGLFCPGSSRIYQLCN 639
Query: 607 TDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYF 666
+ C + + DFR +QC+++N K +W P Y+ + +DRCKLYC+ +F
Sbjct: 640 INPCNENSLDFRAQQCAEYNSKPFR----GWFYQWKP-YTKVEEEDRCKLYCKAENFEFF 694
Query: 667 YLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGV 726
+ + V+DGTPC +D+C+ G C GCDH L S A D CGVC GDNS+CK G+
Sbjct: 695 FAMSGKVKDGTPCSPNKNDVCIDGVCELVGCDHELGSKAVSDACGVCKGDNSTCKFYKGL 754
Query: 727 FNSSHYG--YNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSK 784
+ + H Y VV IPAGA +++I++ Q SYLA+ + G + +
Sbjct: 755 YLNQHKANEYYPVVLIPAGARSIEIQEL----QVSSSYLAVRSLSQKYYLTGGWSIDW-P 809
Query: 785 KEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIP-LEE 843
E G T EY S N ER+ + + L+ ++L G NP + + + +P +
Sbjct: 810 GEFPFAG--TTFEYQRSFNRPERLYAPGPTNETLVFEILMQGK--NPGIAWKYALPKVMN 865
Query: 844 RSDMFTWDPYGPW----EGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQS 899
+ T P W C+ C G + ++ V+ C P +
Sbjct: 866 GTPPATKRPAYTWSIVQSECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKI 925
Query: 900 CNT-DCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQ 958
CN C W S CS C G ++ I C++ + + + H P
Sbjct: 926 CNAFSCPAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVL--HSLCPVSTPTQV 983
Query: 959 ELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSR-VTRENC 1017
+ C+ + +W WSQCS++CG G R RE C + L +++C L R +E C
Sbjct: 984 QACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGC 1043
Query: 1018 NEFSCP-----SWAASEWSECLVTCGKGTKQRQVWC-----QLNVDHLSDGFCNSSTKP- 1066
CP W AS WSEC TCG G ++R++ C Q + + C + KP
Sbjct: 1044 VLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPN 1103
Query: 1067 -ESLSPCELHTC---------ASWQVGPWGPCTTTCGHGYQMRDVKCVNE 1106
+ C C A W PW CT TCG G Q R V CV +
Sbjct: 1104 LDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQ 1153
Score = 149 bits (376), Expect = 3e-35
Identities = 88/314 (28%), Positives = 140/314 (44%), Gaps = 68/314 (21%)
Query: 1217 SPCSASCGHGKTTRQVLCM-NYHQPIDENYCDPEVRPLMEQE-CSLAACPPAHSHFPSSP 1274
S CS SCG G + +C+ + + ++ ++C + +P+ E + C+ +CP
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPA--------- 933
Query: 1275 VQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVC--- 1331
W G W +CS +C+GG Q R + C
Sbjct: 934 --------------------------------YWMPGEWSTCSKACAGGQQSRKIQCVQK 961
Query: 1332 ---QDENGQSASYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGGGIKSRLVICQF 1387
Q E S C S P ++Q C CP QW+ G W +CS+TCG G++ R ++C+
Sbjct: 962 KPFQKEEAVLHSLCPV-STPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELLCKG 1020
Query: 1388 PNGQILEDHNCEIVNKPPSVIQCHMHACPAD--VSWHQEPWTSCSASCGKGRKYREVFCI 1445
+ L + C + +P C + CP + + W W+ CSA+CG G + RE+ C
Sbjct: 1021 SAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCS 1080
Query: 1446 DQ-FQRKL---EDTNCSQVQKP--PTHKACRSVRCPS---------WKANSWNECSVTCG 1490
++ FQ KL + C ++KP + C CP+ W + W +C+VTCG
Sbjct: 1081 EKGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCG 1140
Query: 1491 SGVQQRDVYCRLKG 1504
GVQ R V+C +G
Sbjct: 1141 GGVQTRSVHCVQQG 1154
Score = 145 bits (367), Expect = 3e-34
Identities = 95/341 (27%), Positives = 146/341 (42%), Gaps = 74/341 (21%)
Query: 1164 CSVSCGRG-TQARYVSCRDALDRIADESYCAHLPRPA---EIWDCFTPCGEWQAGDWSPC 1219
CSVSCG G + + RD ++ + S+C+ +P +I + F+ W G+WS C
Sbjct: 885 CSVSCGGGYINVKAICLRDQNTQV-NSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWSTC 943
Query: 1220 SASCGHGKTTRQVLCMNY-----HQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSP 1274
S +C G+ +R++ C+ + + + C P P Q C+ ACPP
Sbjct: 944 SKACAGGQQSRKIQCVQKKPFQKEEAVLHSLC-PVSTPTQVQACNSHACPP--------- 993
Query: 1275 VQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDE 1334
QW GPW CS +C G++ R ++C+
Sbjct: 994 --------------------------------QWSLGPWSQCSKTCGRGVRKRELLCKGS 1021
Query: 1335 NGQSASYCDAASKP-PELQQ-CGPGPCP-----QWNYGNWGECSQTCGGGIKSRLVICQF 1387
++ S P PELQ+ C G CP QW +W ECS TCG G++ R + C
Sbjct: 1022 AAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSE 1081
Query: 1388 PNGQ----ILEDHNCEIVNKPPSVIQ--CHMHACPAD------VSWHQEPWTSCSASCGK 1435
Q + C + KP ++ C+ ACPA W+ PW C+ +CG
Sbjct: 1082 KGFQGKLITFPERRCRNIKKPNLDLEETCNRRACPAHPVYNMVAGWYSLPWQQCTVTCGG 1141
Query: 1436 GRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPS 1476
G + R V C+ Q + ++C QKPP +AC + CP+
Sbjct: 1142 GVQTRSVHCVQQGR---PSSSCLLHQKPPVLRACNTNFCPA 1179
Score = 139 bits (349), Expect = 3e-32
Identities = 82/294 (27%), Positives = 133/294 (45%), Gaps = 43/294 (14%)
Query: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQ-ELCHGNCV 966
W ++ +SECS CG GY + C++ Q QV+ +C + KP T+ ++C+
Sbjct: 878 WSIV-QSECSVSCGGGYINVKAICLR-----DQNTQVNSSFCSAKTKPVTEPKICNAFSC 931
Query: 967 FTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTR----ENCNEFSC 1022
W EWS CS++C GG++SR+ C+ + + L V+ + CN +C
Sbjct: 932 PAYWMPGEWSTCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHAC 991
Query: 1023 P-SWAASEWSECLVTCGKGTKQRQVWCQLNV-DHLSDGFCNSSTKPESLSPCELHTCAS- 1079
P W+ WS+C TCG+G ++R++ C+ + + L + C S +PE C L C
Sbjct: 992 PPQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKN 1051
Query: 1080 ----WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVL---EDTECHEASRPS-------D 1125
W W C+ TCG G + R++KC + L + C +P+ +
Sbjct: 1052 SRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETCN 1111
Query: 1126 RQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC 1179
R++C P + +A W W C+V+CG G Q R V C
Sbjct: 1112 RRACPAHP---------------VYNMVAGWYSLPWQQCTVTCGGGVQTRSVHC 1150
Score = 129 bits (325), Expect = 2e-29
Identities = 99/351 (28%), Positives = 143/351 (40%), Gaps = 76/351 (21%)
Query: 1031 SECLVTCGKGTKQRQVWCQLNVD-HLSDGFCNSSTKPESLSP-CELHTC-ASWQVGPWGP 1087
SEC V+CG G + C + + ++ FC++ TKP + C +C A W G W
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
Query: 1088 CTTTCGHGYQMRDVKCVNELASAVLEDTECHE---ASRPSDRQSCVLTPCSFISKLETAL 1144
C+ C G Q R ++CV + E+ H S P+ Q+C C
Sbjct: 943 CSKACAGGQQSRKIQCVQKKPFQK-EEAVLHSLCPVSTPTQVQACNSHACP--------- 992
Query: 1145 LPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC 1204
QW G W+ CS +CGRG + R + C+ + ES C LPRP C
Sbjct: 993 ---------PQWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGC 1043
Query: 1205 -FTPCG-----EWQAGDWSPCSASCGHGKTTRQVLC---------MNYHQPIDENYCDPE 1249
C +W A WS CSA+CG G R++ C + + + N P
Sbjct: 1044 VLGRCPKNSRLQWVASSWSECSATCGLGVRKREMKCSEKGFQGKLITFPERRCRNIKKPN 1103
Query: 1250 VRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWR 1309
+ +E+ C+ AC PAH V+ V G W
Sbjct: 1104 LD--LEETCNRRAC-PAHP------------------------------VYNMVAG--WY 1128
Query: 1310 TGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCP 1360
+ PW C+ +C GG+Q R+V C + G+ +S C KPP L+ C CP
Sbjct: 1129 SLPWQQCTVTCGGGVQTRSVHCV-QQGRPSSSCLLHQKPPVLRACNTNFCP 1178
Score = 123 bits (309), Expect = 2e-27
Identities = 89/349 (25%), Positives = 137/349 (39%), Gaps = 63/349 (18%)
Query: 1369 ECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ-CHMHACPADVSWHQEPWT 1427
ECS +CGGG + IC + C KP + + C+ +CPA W W+
Sbjct: 884 ECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPA--YWMPGEWS 941
Query: 1428 SCSASCGKGRKYREVFCIDQFQRKLEDT---NCSQVQKPPTHKACRSVRCP-SWKANSWN 1483
+CS +C G++ R++ C+ + + E+ + V P +AC S CP W W+
Sbjct: 942 TCSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWS 1001
Query: 1484 ECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGME---RGR 1540
+CS TCG GV++R++ C+ + E C RP Q C C ++ ++
Sbjct: 1002 QCSKTCGRGVRKRELLCKGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSRLQWVASSW 1061
Query: 1541 LNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQC 1600
CS +C + M+C++ + I+ + CRN
Sbjct: 1062 SECSATCGLGVRKREMKCSEKG--------FQGKLITFPERRCRN--------------- 1098
Query: 1601 ANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKV 1660
KK L + CP P VY + A W
Sbjct: 1099 --------------------IKKPNLDLEETCNRRACPAHP---VYNMV------AGWYS 1129
Query: 1661 GKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
W +C+VTCG G+ R V C+ + G S CL H KP + C N C
Sbjct: 1130 LPWQQCTVTCGGGVQTRSVHCV-QQGRPSSSCLLHQKPPVLRACNTNFC 1177
Score = 72.4 bits (176), Expect = 4e-12
Identities = 54/212 (25%), Positives = 83/212 (39%), Gaps = 22/212 (10%)
Query: 1483 NECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLN 1542
+ECSV+CG G C QV C T+P ++ + + M
Sbjct: 883 SECSVSCGGGYINVKAICLRDQNTQVNSSFCSAKTKPVTEPKICNAFSCPAYWMPGEWST 942
Query: 1543 CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKN---CRNPPCNYIVVTADSSQ 1599
CS +C ++++C + Q E V +S T C + C SQ
Sbjct: 943 CSKACAGGQQSRKIQCVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQ 1002
Query: 1600 CANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQ-CI------NSC 1652
C+ CG R+R C K + +C +P ++ + C+ NS
Sbjct: 1003 CSKTCGRGVRKRELLC---------KGSAAETLPESQCTSLPRPELQEGCVLGRCPKNSR 1053
Query: 1653 LHLATWKVGKWSKCSVTCGIGIMKRQVKCITK 1684
L W WS+CS TCG+G+ KR++KC K
Sbjct: 1054 LQ---WVASSWSECSATCGLGVRKREMKCSEK 1082
Score = 38.5 bits (88), Expect = 0.063
Identities = 24/89 (26%), Positives = 38/89 (42%), Gaps = 4/89 (4%)
Query: 545 CVNKETETRPVNGEWGPWE--PYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKF 602
C + PV W P+ C+ TCGGG+++ + C + + +
Sbjct: 1110 CNRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVL 1169
Query: 603 RSCNTDSCPKGTQDFREKQCSD-FNGKHL 630
R+CNT+ CP + + C D FN HL
Sbjct: 1170 RACNTNFCP-APEKREDPSCVDFFNWCHL 1197
Score = 38.1 bits (87), Expect = 0.083
Identities = 18/41 (43%), Positives = 24/41 (58%), Gaps = 2/41 (4%)
Query: 1353 QCGPGPCP-QWN-YGNWGECSQTCGGGIKSRLVICQFPNGQ 1391
+ GP P QW+ + W ECS+TCGGG+K + C P Q
Sbjct: 582 ELGPRPIHGQWSAWSKWSECSRTCGGGVKFQERHCNNPKPQ 622
Score = 31.6 bits (70), Expect = 7.8
Identities = 12/25 (48%), Positives = 18/25 (72%), Gaps = 1/25 (4%)
Query: 1477 WKA-NSWNECSVTCGSGVQQRDVYC 1500
W A + W+ECS TCG GV+ ++ +C
Sbjct: 592 WSAWSKWSECSRTCGGGVKFQERHC 616
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 547 bits (1410), Expect = e-155
Identities = 308/810 (38%), Positives = 432/810 (53%), Gaps = 76/810 (9%)
Query: 41 EVVIPERVNEFGEVFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFL 100
E+V PE++N G V P S P R R A+G+ L L D+
Sbjct: 60 EIVFPEKLN--GSVLPGSG--------------APARLLCRLQAFGETLLLELEQDSGVQ 103
Query: 101 AAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGG-LTGTFKGQN 159
G T +LG ++ G + G +N + A + GG L G + +
Sbjct: 104 VEGLTVQYLGQAPELLGGAEPGT------YLTGTINGDPESVASLHWDGGALLGVLQYRG 157
Query: 160 GEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTYS 219
E L+P+ G G H++ R+ S
Sbjct: 158 AELHLQPL--EGGTPNSAGGPGAHILRRKS---------------------------PAS 188
Query: 220 NMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNL 279
NV + LG S R R KR S R++E +V AD K+ + HG+ L
Sbjct: 189 GQGPMCNV--KAPLGSPSP--------RPRRAKRFASLSRFVETLVVADDKMAAFHGAGL 238
Query: 280 QNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQT 339
+ Y+LT+M+ A +K PSI N + +VV +LV++ EEGP + A TL++FC+WQ+
Sbjct: 239 KRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRG 298
Query: 340 QNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAF 399
N +D P H DTA+L TR+D+C C+ LG++ +GT+CDP +SC I E+ GL SAF
Sbjct: 299 LNTPEDSDPDHFDTAILFTRQDLCGVST-CDTLGMADVGTVCDPARSCAIVEDDGLQSAF 357
Query: 400 TIAHELGHTLGVQHDDNPRCKEMK---VTKYHVMAPALSFHMSPWS-WSNCSRKYVTEFL 455
T AHELGH + HD++ C + T HVMAP ++ H+ P WS CS +++T+FL
Sbjct: 358 TAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMA-HVDPEEPWSPCSARFITDFL 416
Query: 456 DTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHINI-CMHLWCTST 514
D GYG CLLDKP+ ++ LP PG YD ++QC+L FGP S+ CP + C LWC+
Sbjct: 417 DNGYGHCLLDKPEAPLH-LPVTFPGKDYDADRQCQLTFGPDSRHCPQLPPPCAALWCSGH 475
Query: 515 EKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETR---PVNGEWGPWEPYSSCSRT 571
H C T+H P ADGT CGP C G C++ + P G WGPW P+ CSRT
Sbjct: 476 LNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRT 535
Query: 572 CGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQ-DFREKQCSDFNGKHL 630
CGGG++ ++R C RP PRNGG YC GRR +FRSCNT+ CP G+ FRE+QC+ +N +
Sbjct: 536 CGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTD 595
Query: 631 DISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQG 690
P + W+PRY+G+ +D+CKL CQ Y+Y+L+ V DGTPC ++ +CVQG
Sbjct: 596 LFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVVDGTPCSPDSSSVCVQG 655
Query: 691 QCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYGYNVVVKIPAGATNVDIR 750
+C+ AGCD ++ S K DKC VCGGD S C +G F YGYN VV IPAGAT++ +R
Sbjct: 656 RCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFRYGYNNVVTIPAGATHILVR 715
Query: 751 QYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINS 810
Q G YLAL +G++ NG + L S ++ + G + YSG+ A E ++
Sbjct: 716 QQGNPGH-RSIYLALKLPDGSYALNGEYTLMPSPTDVVLPGA-VSLRYSGATAASETLSG 773
Query: 811 TNRQEKELILQVLCVGNLYNPDVHYSFNIP 840
+ L LQVL GN + + YSF +P
Sbjct: 774 HGPLAQPLTLQVLVAGNPQDTRLRYSFFVP 803
Score = 35.8 bits (81), Expect = 0.41
Identities = 28/84 (33%), Positives = 38/84 (45%), Gaps = 20/84 (23%)
Query: 1320 CSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPC-----------PQ---WN-Y 1364
CSG L A+ CQ ++ + + D P Q C G C PQ W +
Sbjct: 472 CSGHLNGHAM-CQTKH---SPWADGTPCGPA-QACMGGRCLHMDQLQDFNIPQAGGWGPW 526
Query: 1365 GNWGECSQTCGGGIKSRLVICQFP 1388
G WG+CS+TCGGG++ C P
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRP 550
Score = 35.8 bits (81), Expect = 0.41
Identities = 18/53 (33%), Positives = 24/53 (45%), Gaps = 7/53 (13%)
Query: 1311 GPWGSCSSSCSGGLQHRAVVCQ---DENGQSASYCDAASKPPELQQCGPGPCP 1360
GPWG CS +C GG+Q + C NG YC+ + + C CP
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDCTRPVPRNG--GKYCE--GRRTRFRSCNTEDCP 575
Score = 32.3 bits (72), Expect = 4.5
Identities = 19/61 (31%), Positives = 26/61 (42%), Gaps = 2/61 (3%)
Query: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASEWS 1031
+ W CSR+CGGG + C R C E R +CN CP+ +A +
Sbjct: 526 WGPWGDCSRTCGGGVQFSSRDCTRPV-PRNGGKYC-EGRRTRFRSCNTEDCPTGSALTFR 583
Query: 1032 E 1032
E
Sbjct: 584 E 584
Score = 31.6 bits (70), Expect = 7.8
Identities = 11/21 (52%), Positives = 12/21 (57%)
Query: 1083 GPWGPCTTTCGHGYQMRDVKC 1103
GPWG C+ TCG G Q C
Sbjct: 527 GPWGDCSRTCGGGVQFSSRDC 547
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 534 bits (1375), Expect = e-151
Identities = 339/1021 (33%), Positives = 513/1021 (50%), Gaps = 88/1021 (8%)
Query: 29 RQEALVRTLTSYEVVIPERVNEFGEVFPQSHHF----SRQKRSSEALEPMPFRTHYRFTA 84
RQE ++ L Y VV P RV+ G H+ SR+KR + E +YR +
Sbjct: 41 RQEHFIKGLPEYHVVGPVRVDASGHFLSYGLHYPITSSRRKRDLDGSEDW---VYYRISH 97
Query: 85 YGQLFQLNLTADASFLAAGYT-EVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDY-- 141
+ NLT + FL+ Y E G + + P C G V Q
Sbjct: 98 EEKDLFFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPL----CHLSGTVLQQGTRVG 153
Query: 142 KAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYC 201
A +S C GLTG F+ +G++F+EP+ K + +G PH++YR+
Sbjct: 154 TAALSACHGLTGFFQLPHGDFFIEPVKK---HPLVEGGYHPHIVYRRQ------------ 198
Query: 202 SVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYI 261
+ KE + N+++ + +E+ H N+P + S +R IS R++
Sbjct: 199 --KVPETKEPTCGLKDSVNISQKQELWREKWERH---NLPSR-----SLSRRSISKERWV 248
Query: 262 EIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGP 320
E +V AD K++ HGS N+++YILT+M++V ++ +PSIGN IHIVVV+L+++ EE+G
Sbjct: 249 ETLVVADTKMIEYHGSENVESYILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEEEEQGL 308
Query: 321 VINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEK-CNMLGLSYLGT 379
I TL +FC WQ++ N D++P HHD AVL+TR+DIC+ + C LGLS+L
Sbjct: 309 KIVHHAEKTLSSFCKWQKSINPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSG 368
Query: 380 ICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMS 439
+C P +SC INE+ GL AFTIAHELGH+ G+QHD E ++M+ L + +
Sbjct: 369 MCQPHRSCNINEDSGLPLAFTIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPT 428
Query: 440 PWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQM 499
P +WS CS +Y+T FLD G+G CL D P ++ PG YD + QC+L +GP +
Sbjct: 429 PLTWSKCSEEYITRFLDRGWGFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATF 488
Query: 500 CPHI-NICMHLWCTSTEKLHKG-CFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNG 557
C + N+C LWC+ KG C ++ ADGT CG C G C+ + + G
Sbjct: 489 CQEVENVCQTLWCSV-----KGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPG 543
Query: 558 EWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDF 617
WG W P+S CSRTCG G++SA R CN PEP+ GG YC G R ++R CN C F
Sbjct: 544 GWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTF 603
Query: 618 REKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGT 677
R+ QCS+F+ + W P ++ C+LYC+ + + D V DGT
Sbjct: 604 RQMQCSEFD----TVPYKNELYHWFPIFN---PAHPCELYCRPIDGQFSEKMLDAVIDGT 656
Query: 678 PC--GTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSH-YGY 734
PC G + ++C+ G C GCD+ ++S+A D+CGVC GD SSC+T+ +F GY
Sbjct: 657 PCFEGGNSRNVCINGICKMVGCDYEIDSNATEDRCGVCLGDGSSCQTVRKMFKQKEGSGY 716
Query: 735 NVVVKIPAGATNVDIRQYSYSGQPDDSYLAL-SDAEGNFLFNGNFLLSTSKKEINVQGTR 793
+ IP GA ++ + + +G ++LA+ S+ + NG F++ + N +
Sbjct: 717 VDIGLIPKGARDIRVMEIEGAG----NFLAIRSEDPEKYYLNGGFIIQWNG---NYKLAG 769
Query: 794 TVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPL-----EERSDMF 848
TV +Y + +E++ +T + + +Q+L + NP + Y + I + M+
Sbjct: 770 TVFQYDRKGD-LEKLMATGPTNESVWIQLLF--QVTNPGIKYEYTIQKDGLDNDVEQQMY 826
Query: 849 TWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD-CEL 906
W YG W C+ C G++R+ CI K +V CD P+ + C+ C
Sbjct: 827 FWQ-YGHWTECSVTCGTGIRRQTAHCI-KKGRGMVKATFCDPETQPNGRQKKCHEKACPP 884
Query: 907 RWHVIGKSECSSQCG-QGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNC 965
RW CS+ CG G + + C++ + + Q + D C LKP T C+ +
Sbjct: 885 RWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTD--CQHLLKPKTLLSCNRDI 942
Query: 966 VF-TRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRV-TRENCNEFSCP 1023
+ + W WS+CS SCGGG R R C N D C + +R C CP
Sbjct: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNH-----DEPCDVTRKPNSRALCGLQQCP 997
Query: 1024 S 1024
S
Sbjct: 998 S 998
Score = 137 bits (346), Expect = 8e-32
Identities = 75/230 (32%), Positives = 105/230 (45%), Gaps = 22/230 (9%)
Query: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNW 1367
W G W CS++C G R V C Q S C A +P ++C PC W GNW
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECST---QMDSDCAAIQRPDPAKRCHLRPCAGWKVGNW 1373
Query: 1368 GECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVN--KPPSVIQCHMHACPADVSWHQE 1424
+CS+ C GG K R + C + + L +C+ + PP + C+ C A W E
Sbjct: 1374 SKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEA---WQVE 1430
Query: 1425 PWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNE 1484
PW+ CS SCG G + R VFC C ++P + +C C W +W+
Sbjct: 1431 PWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSCNEHLCCHWATGNWDL 1482
Query: 1485 CSVTCGSGVQQRDVYCRLKGVGQVVEE----MCDQSTRPCSQRRCWSQDC 1530
CS +CG G Q+R V C + G E+ +CD RP ++C Q C
Sbjct: 1483 CSTSCGGGFQKRTVQC-VPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 129 bits (323), Expect = 4e-29
Identities = 77/244 (31%), Positives = 106/244 (43%), Gaps = 34/244 (13%)
Query: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGP 1084
W WSEC TCG G R+V C +D SD C + +P+ C L CA W+VG
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQMD--SD--CAAIQRPDPAKRCHLRPCAGWKVGN 1372
Query: 1085 WGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETAL 1144
W C+ C G+++R+++CV D+ H RP C F++ + L
Sbjct: 1373 WSKCSRNCSGGFKIREIQCV---------DSRDHRNLRPFH--------CQFLAGIPPPL 1415
Query: 1145 LPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC 1204
+ + W+ W+ CS SCG G Q R V C L C RP C
Sbjct: 1416 SMSCNPEPCEAWQVEPWSQCSRSCGGGVQERGVFCPGGL--------CDWTKRPTSTMSC 1467
Query: 1205 FTP-CGEWQAGDWSPCSASCGHGKTTRQVLCM----NYHQPIDENYCDPEVRPLMEQECS 1259
C W G+W CS SCG G R V C+ N + D+ CD + RP ++C+
Sbjct: 1468 NEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCN 1527
Query: 1260 LAAC 1263
AC
Sbjct: 1528 QQAC 1531
Score = 127 bits (320), Expect = 8e-29
Identities = 79/271 (29%), Positives = 118/271 (43%), Gaps = 30/271 (11%)
Query: 876 KSDHSVVSDKECDHLPLPSFVT------QSCNTDCELRWHVIGKSECSSQCGQGYRTLDI 929
KS V+++++ L F+ Q N W V SECS+ CG G +
Sbjct: 1279 KSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRV 1338
Query: 930 HCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSR 989
C + Q+D C +P + CH W WS+CSR+C GG + R
Sbjct: 1339 EC---------STQMDSD-CAAIQRPDPAKRCHLRPC-AGWKVGNWSKCSRNCSGGFKIR 1387
Query: 990 ESYCMNNFGHR-LADNECQELSRVTRE---NCNEFSCPSWAASEWSECLVTCGKGTKQRQ 1045
E C+++ HR L CQ L+ + +CN C +W WS+C +CG G ++R
Sbjct: 1388 EIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQERG 1447
Query: 1046 VWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVN 1105
V+C G C+ + +P S C H C W G W C+T+CG G+Q R V+CV
Sbjct: 1448 VFCP-------GGLCDWTKRPTSTMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVP 1500
Query: 1106 ELASAVLEDTE--CHEASRPSDRQSCVLTPC 1134
+ + + C RP + + C C
Sbjct: 1501 SEGNKTEDQDQCLCDHKPRPPEFKKCNQQAC 1531
Score = 126 bits (317), Expect = 2e-28
Identities = 88/314 (28%), Positives = 118/314 (37%), Gaps = 85/314 (27%)
Query: 1055 LSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLED 1114
+++GF +++ + L+ H A W VG W C+TTCG G R V+C ++ D
Sbjct: 1294 ITEGFLLNASNYKQLT--NGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQM------D 1345
Query: 1115 TECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQA 1174
++C RP + C L PC A W+ G+W+ CS +C G +
Sbjct: 1346 SDCAAIQRPDPAKRCHLRPC-------------------AGWKVGNWSKCSRNCSGGFKI 1386
Query: 1175 RYVSCRDALD----RIADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTR 1230
R + C D+ D R + A +P P + PC WQ WS CS SCG G R
Sbjct: 1387 REIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQVEPWSQCSRSCGGGVQER 1446
Query: 1231 QVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQK 1290
V C CD RP C
Sbjct: 1447 GVFCPG-------GLCDWTKRPTSTMSC-------------------------------- 1467
Query: 1291 LEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENG-----QSASYCDAA 1345
NE+ H W TG W CS+SC GG Q R V C G Q CD
Sbjct: 1468 ---NEHLCCH-------WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHK 1517
Query: 1346 SKPPELQQCGPGPC 1359
+PPE ++C C
Sbjct: 1518 PRPPEFKKCNQQAC 1531
Score = 114 bits (286), Expect = 7e-25
Identities = 65/176 (36%), Positives = 91/176 (51%), Gaps = 14/176 (7%)
Query: 1362 WNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPS-VIQCHMHACPADVS 1420
W YG+W ECS TCG GI+ + C +++ C+ +P +CH ACP
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP--R 885
Query: 1421 WHQEPWTSCSASCG-KGRKYREVFCIDQF---QRKLEDTNCSQVQKPPTHKAC-RSVRCP 1475
W W +CSA+CG G K R V CI ++ L T+C + KP T +C R + CP
Sbjct: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCP 945
Query: 1476 S-WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
S W +W+ECSV+CG GV+ R V C + +E CD + +P S+ C Q C
Sbjct: 946 SDWTVGNWSECSVSCGGGVRIRSVTC-----AKNHDEPCDVTRKPNSRALCGLQQC 996
Score = 96.3 bits (238), Expect = 3e-19
Identities = 58/178 (32%), Positives = 85/178 (47%), Gaps = 16/178 (8%)
Query: 1308 WRTGPWGSCSSSCSGGLQHRAVVC--QDENGQSASYCDAASKPPELQQ-CGPGPCP-QWN 1363
W+ G W CS +C G++ + C + A++CD ++P Q+ C CP +W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 1364 YGNWGECSQTCG-GGIKSRLVIC---QFPNGQILEDHNCEIVNKPPSVIQCHMH-ACPAD 1418
G W CS TCG G K R V+C + Q L +C+ + KP +++ C+ CP+D
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSD 947
Query: 1419 VSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPS 1476
W W+ CS SCG G + R V C K D C +KP + C +CPS
Sbjct: 948 --WTVGNWSECSVSCGGGVRIRSVTC-----AKNHDEPCDVTRKPNSRALCGLQQCPS 998
Score = 95.1 bits (235), Expect = 6e-19
Identities = 62/217 (28%), Positives = 86/217 (39%), Gaps = 56/217 (25%)
Query: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNYHQP-IDENYCDPEVRPLMEQE-CSLAACPPAHS 1268
WQ G W+ CS +CG G + C+ + + +CDPE +P Q+ C ACPP
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPP--- 884
Query: 1269 HFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG-GLQHR 1327
+W G W +CS++C G + R
Sbjct: 885 --------------------------------------RWWAGEWEACSATCGPHGEKKR 906
Query: 1328 AVVC-----QDENGQSASYCDAASKPPELQQCGPGP-CPQ-WNYGNWGECSQTCGGGIKS 1380
V+C DE + C KP L C CP W GNW ECS +CGGG++
Sbjct: 907 TVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRI 966
Query: 1381 RLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPA 1417
R V C + D C++ KP S C + CP+
Sbjct: 967 RSVTCAKNH-----DEPCDVTRKPNSRALCGLQQCPS 998
Score = 93.2 bits (230), Expect = 2e-18
Identities = 62/180 (34%), Positives = 83/180 (46%), Gaps = 17/180 (9%)
Query: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPP-TQELCHGNCV 966
W +ECS CG G R HC+K +G+ + V +C + +P Q+ CH
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIK----KGRGM-VKATFCDPETQPNGRQKKCHEKAC 882
Query: 967 FTRWHYSEWSQCSRSCGG-GERSRESYCMNNF---GHRLADNECQELSRV-TRENCN-EF 1020
RW EW CS +CG GE+ R C+ L +CQ L + T +CN +
Sbjct: 883 PPRWWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDI 942
Query: 1021 SCPS-WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCAS 1079
CPS W WSEC V+CG G + R V C N D C+ + KP S + C L C S
Sbjct: 943 LCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEP----CDVTRKPNSRALCGLQQCPS 998
Score = 92.4 bits (228), Expect = 4e-18
Identities = 55/177 (31%), Positives = 79/177 (44%), Gaps = 20/177 (11%)
Query: 970 WHYSEWSQCSRSCGGGERSRESYCMNN----FGHRLADNECQELSRVTRENCNEFSCPS- 1024
W Y W++CS +CG G R + ++C+ D E Q R ++ C+E +CP
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGR--QKKCHEKACPPR 885
Query: 1025 WAASEWSECLVTCG-KGTKQRQVWCQLNV----DHLSDGFCNSSTKPESLSPC--ELHTC 1077
W A EW C TCG G K+R V C + L C KP++L C ++
Sbjct: 886 WWAGEWEACSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCP 945
Query: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
+ W VG W C+ +CG G ++R V C D C +P+ R C L C
Sbjct: 946 SDWTVGNWSECSVSCGGGVRIRSVTCAKN------HDEPCDVTRKPNSRALCGLQQC 996
Score = 88.6 bits (218), Expect = 5e-17
Identities = 66/235 (28%), Positives = 92/235 (39%), Gaps = 34/235 (14%)
Query: 1040 GTKQRQVWCQLNVDHLSDGFCNSST-KPESLSPCELHTCASWQVGPWGPCTTTCGHGYQM 1098
G VW QL + G T + + L WQ G W C+ TCG G +
Sbjct: 787 GPTNESVWIQLLFQVTNPGIKYEYTIQKDGLDNDVEQQMYFWQYGHWTECSVTCGTGIRR 846
Query: 1099 RDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRH 1158
+ C+ + +++ T C ++P+ RQ C E A P +W
Sbjct: 847 QTAHCIKK-GRGMVKATFCDPETQPNGRQK----KCH-----EKACPP--------RWWA 888
Query: 1159 GSWTPCSVSCG-RGTQARYVSCRDALDRIADESY-----CAHLPRPAEIWDCFTPC---G 1209
G W CS +CG G + R V C + ++DE C HL +P + C
Sbjct: 889 GEWEACSATCGPHGEKKRTVLCIQTM--VSDEQALPPTDCQHLLKPKTLLSCNRDILCPS 946
Query: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACP 1264
+W G+WS CS SCG G R V C H + CD +P C L CP
Sbjct: 947 DWTVGNWSECSVSCGGGVRIRSVTCAKNH----DEPCDVTRKPNSRALCGLQQCP 997
Score = 85.1 bits (209), Expect = 6e-16
Identities = 52/168 (30%), Positives = 72/168 (42%), Gaps = 19/168 (11%)
Query: 1025 WAASEWSECLVTCGKGTKQRQVWC-QLNVDHLSDGFCNSSTKPESLSP-CELHTCAS-WQ 1081
W W+EC VTCG G +++ C + + FC+ T+P C C W
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 1082 VGPWGPCTTTCG-HGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL 1140
G W C+ TCG HG + R V C+ + S D Q+ T C + K
Sbjct: 888 AGEWEACSATCGPHGEKKRTVLCIQTMVS---------------DEQALPPTDCQHLLKP 932
Query: 1141 ETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIAD 1188
+T L I + W G+W+ CSVSCG G + R V+C D D
Sbjct: 933 KTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCD 980
Score = 81.6 bits (200), Expect = 7e-15
Identities = 63/243 (25%), Positives = 98/243 (40%), Gaps = 36/243 (14%)
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGM 1536
W +W+ECS TCG G R V C + ++ C RP +RC + C G
Sbjct: 1317 WIVGNWSECSTTCGLGAYWRRVECSTQ-----MDSDCAAIQRPDPAKRCHLRPCA---GW 1368
Query: 1537 ERGRLN-CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLT---SKNCRNPPCNYIV 1592
+ G + CS +C + ++C D++ + + + S +C PC
Sbjct: 1369 KVGNWSKCSRNCSGGFKIREIQCVDSRDHRNLRPFHCQFLAGIPPPLSMSCNPEPCEAWQ 1428
Query: 1593 VTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSC 1652
V SQC+ +CG ++R +C P + P+S + + C
Sbjct: 1429 VEP-WSQCSRSCGGGVQERGVFC---------------PGGLCDWTKRPTSTMSCNEHLC 1472
Query: 1653 LHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSD-----LCLNHLKPGAQKKCYAN 1707
H W G W CS +CG G KR V+C+ G ++ LC + +P KKC
Sbjct: 1473 CH---WATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEFKKCNQQ 1529
Query: 1708 DCK 1710
CK
Sbjct: 1530 ACK 1532
Score = 57.4 bits (137), Expect = 1e-07
Identities = 40/148 (27%), Positives = 63/148 (42%), Gaps = 9/148 (6%)
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCS-QRRCWSQDCVQHKG 1535
W+ W ECSVTCG+G++++ +C KG G V CD T+P Q++C + C
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWW 887
Query: 1536 MERGRLNCSTSCERKDSHQR------MECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCN 1589
CS +C +R +D Q + + +L S N R+ C
Sbjct: 888 AGEWEA-CSATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKPKTLLSCN-RDILCP 945
Query: 1590 YIVVTADSSQCANNCGFSYRQRITYCTE 1617
+ S+C+ +CG R R C +
Sbjct: 946 SDWTVGNWSECSVSCGGGVRIRSVTCAK 973
Score = 49.7 bits (117), Expect = 3e-05
Identities = 42/177 (23%), Positives = 61/177 (34%), Gaps = 22/177 (12%)
Query: 1543 CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTI-SLTSKNCRNPPCNYIVVTADSSQCA 1601
CS +C Q C V + T + K C C + C+
Sbjct: 836 CSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKACPPRWWAGEWEACS 895
Query: 1602 NNCG-FSYRQRITYCTEIPSTKKHKL------HRLRPIVYQECPVVPSSQVYQCINSCLH 1654
CG ++R C + + + L H L+P + C L
Sbjct: 896 ATCGPHGEKKRTVLCIQTMVSDEQALPPTDCQHLLKP-----------KTLLSCNRDILC 944
Query: 1655 LATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDCKS 1711
+ W VG WS+CSV+CG G+ R V C H D+ KP ++ C C S
Sbjct: 945 PSDWTVGNWSECSVSCGGGVRIRSVTCAKNHDEPCDVT---RKPNSRALCGLQQCPS 998
Score = 48.9 bits (115), Expect = 5e-05
Identities = 23/54 (42%), Positives = 32/54 (59%), Gaps = 3/54 (5%)
Query: 1656 ATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
A W VG WS+CS TCG+G R+V+C T+ + SD C +P K+C+ C
Sbjct: 1315 AHWIVGNWSECSTTCGLGAYWRRVECSTQ--MDSD-CAAIQRPDPAKRCHLRPC 1365
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/55 (40%), Positives = 31/55 (56%), Gaps = 3/55 (5%)
Query: 1658 WKVGKWSKCSVTCGIGIMKRQVKCITKHG--LSSDLCLNHLKP-GAQKKCYANDC 1709
W+ G W++CSVTCG GI ++ CI K + + C +P G QKKC+ C
Sbjct: 828 WQYGHWTECSVTCGTGIRRQTAHCIKKGRGMVKATFCDPETQPNGRQKKCHEKAC 882
Score = 42.4 bits (98), Expect = 0.004
Identities = 34/142 (23%), Positives = 57/142 (40%), Gaps = 27/142 (19%)
Query: 1552 SHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT----------ADSSQCA 1601
+H ++ NQ + ++ SL ++ NY +T + S+C+
Sbjct: 1267 NHLKLPNNMNQTKSSEPVLTEEDATSLITEGFLLNASNYKQLTNGHGSAHWIVGNWSECS 1326
Query: 1602 NNCGF-SYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKV 1660
CG +Y +R+ T++ S RP + C + P A WKV
Sbjct: 1327 TTCGLGAYWRRVECSTQMDSDCAAIQ---RPDPAKRCHLRPC-------------AGWKV 1370
Query: 1661 GKWSKCSVTCGIGIMKRQVKCI 1682
G WSKCS C G R+++C+
Sbjct: 1371 GNWSKCSRNCSGGFKIREIQCV 1392
Score = 37.7 bits (86), Expect = 0.11
Identities = 24/78 (30%), Positives = 32/78 (41%), Gaps = 7/78 (8%)
Query: 1313 WGSCSSSCSGGLQHRA--VVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGEC 1370
W S C L A C ++ A C K PE PG +W+ W C
Sbjct: 500 WCSVKGFCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESI---PGGWGRWS--PWSHC 554
Query: 1371 SQTCGGGIKSRLVICQFP 1388
S+TCG G++S +C P
Sbjct: 555 SRTCGAGVQSAERLCNNP 572
Score = 36.2 bits (82), Expect = 0.32
Identities = 24/79 (30%), Positives = 30/79 (37%), Gaps = 9/79 (11%)
Query: 1179 CRDALDRIADESYCAHLPRPAEIWDCFT--------PCGEWQAGDWSPCSASCGHGKTTR 1230
CR LD AD + C + C T P G + WS CS +CG G +
Sbjct: 507 CRSKLDAAADGTQCGE-KKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQSA 565
Query: 1231 QVLCMNYHQPIDENYCDPE 1249
+ LC N YC E
Sbjct: 566 ERLCNNPEPKFGGKYCTGE 584
Score = 35.0 bits (79), Expect = 0.70
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 23/93 (24%)
Query: 537 GMHCRHGLC--VNKETETRPVNGE----W--GPWEPYSSCSRTCGGGIESATRRC----- 583
G+ C GLC + T T N W G W+ CS +CGGG + T +C
Sbjct: 1447 GVFCPGGLCDWTKRPTSTMSCNEHLCCHWATGNWD---LCSTSCGGGFQKRTVQCVPSEG 1503
Query: 584 NRPEPRNGGNYCV----GRRMKFRSCNTDSCPK 612
N+ E + + C+ R +F+ CN +C K
Sbjct: 1504 NKTEDQ---DQCLCDHKPRPPEFKKCNQQACKK 1533
Score = 34.3 bits (77), Expect = 1.2
Identities = 19/59 (32%), Positives = 24/59 (40%), Gaps = 3/59 (5%)
Query: 1302 SVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQD-ENGQSASYCDAASKPPELQQCGPGPC 1359
S+ G R PW CS +C G+Q +C + E YC K L C PC
Sbjct: 540 SIPGGWGRWSPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRL--CNVHPC 596
Score = 32.3 bits (72), Expect = 4.5
Identities = 16/52 (30%), Positives = 20/52 (38%), Gaps = 2/52 (3%)
Query: 1028 SEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCAS 1079
S WS C TCG G + + C +C K L C +H C S
Sbjct: 549 SPWSHCSRTCGAGVQSAERLCNNPEPKFGGKYCTGERKRYRL--CNVHPCRS 598
Score = 32.0 bits (71), Expect = 5.9
Identities = 18/50 (36%), Positives = 22/50 (44%), Gaps = 9/50 (18%)
Query: 563 EPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC--VGRRMKFRSCNTDSC 610
EP+S CSR+CGGG++ C G C R SCN C
Sbjct: 1430 EPWSQCSRSCGGGVQERGVFC-------PGGLCDWTKRPTSTMSCNEHLC 1472
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 532 bits (1370), Expect = e-150
Identities = 336/993 (33%), Positives = 498/993 (50%), Gaps = 68/993 (6%)
Query: 41 EVVIPERVNEFGEVFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADASFL 100
++V P RV+ G F + R R + Y G+ + NLTA+ L
Sbjct: 44 DIVHPVRVDAGGS-FLSYELWPRALRKRDVSVRRDAPAFYELQYRGRELRFNLTANQHLL 102
Query: 101 AAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQE--DYKAVVSLCGGLTGTFKGQ 158
A G+ T RG + C G+V E A +S C GL G F+
Sbjct: 103 APGFVSE---TRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLKGVFQLS 159
Query: 159 NGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPFHTY 218
N +YF+EP+ D GH +PH++Y++ Q ++S P
Sbjct: 160 NEDYFIEPL---DSAPARPGHAQPHVVYKRQAPERLAQR-----------GDSSAPSTCG 205
Query: 219 SNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRYIEIMVTADAKVVSAHGS- 277
+ +L +ER + + R +R +S +++E +V ADAK+V HG
Sbjct: 206 VQVYPELESRRER----WEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQP 261
Query: 278 NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQ 337
+++Y+LT+M++VA ++ DPSIGN IHI +V+LV++ EEE I TLK+FC WQ
Sbjct: 262 QVESYVLTIMNMVAGLFHDPSIGNPIHITIVRLVLLEDEEEDLKITHHADNTLKSFCKWQ 321
Query: 338 QTQNDLDDVHPSHHDTAVLITREDICSSKEK-CNMLGLSYLGTICDPLQSCFINEEKGLI 396
++ N D HP HHDTA+L+TR+D+C++ + C LGLS++ +C P +SC INE+ GL
Sbjct: 322 KSINMKGDAHPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLP 381
Query: 397 SAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLD 456
AFT+AHELGH+ G+QHD + E + +M+P L + +P +WS CSR+Y+T FLD
Sbjct: 382 LAFTVAHELGHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLD 441
Query: 457 TGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCPHI-NICMHLWCTSTE 515
G+G CL D P ++I + PS PG YD + QC L +G S C + N+C LWC+
Sbjct: 442 RGWGLCLDDPPAKDIIDFPSVPPGVLYDVSHQCRLQYGAYSAFCEDMDNVCHTLWCS--- 498
Query: 516 KLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGG 575
+ C ++ DGT CG C G CV V+G W W +S CSR+CG G
Sbjct: 499 -VGTTCHSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAVDGGWSGWSAWSICSRSCGMG 557
Query: 576 IESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGI 635
++SA R+C +P P+ G YCVG R +FR CN +CP G FR QCS H D
Sbjct: 558 VQSAERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCS-----HFDAMLY 612
Query: 636 PSNVR-WLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPC--GTETHDICVQGQC 692
+ W+P + + + C+L+C+ A + L+D V DGTPC + D+C+ G C
Sbjct: 613 KGQLHTWVPVVNDV---NPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGIC 669
Query: 693 MAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSH-YGYNVVVKIPAGATNVDIRQ 751
GCD ++S A D+CGVC G+ S+C T++G F + GY V IPAGA + I++
Sbjct: 670 KNVGCDFEIDSGAMEDRCGVCHGNGSTCHTVSGTFEEAEGLGYVDVGLIPAGAREIRIQE 729
Query: 752 YSYSGQPDDSYLAL-SDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINS 810
+ + ++LAL S+ + NG + + + + Q T Y+ N E + S
Sbjct: 730 VAEAA----NFLALRSEDPEKYFLNGGWTIQWNG---DYQVAGTTFTYARRGN-WENLTS 781
Query: 811 TNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERS------DMFTWDPYGPWEGCTKMC- 863
++ + +Q+L + NP VHY + I E +F+W YGPW CT C
Sbjct: 782 PGPTKEPVWIQLLFQES--NPGVHYEYTIHREAGGHDEVPPPVFSWH-YGPWTKCTVTCG 838
Query: 864 QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQ 922
+G+QR+N+ C+ + V ++ CD L P + C+ C RW CSS CG
Sbjct: 839 RGVQRQNVYCLER-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCSSSCGP 897
Query: 923 GYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELC--HGNCVFTRWHYSEWSQCSR 980
G + S+ + ++ C +PPT+ C H C T W WSQCS
Sbjct: 898 GGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPAT-WAVGNWSQCSV 956
Query: 981 SCGGGERSRESYCMNNFGHRLADNECQELSRVT 1013
+CG G + R C N+ G D Q S VT
Sbjct: 957 TCGEGTQRRNVLCTNDTGVP-CDEAQQPASEVT 988
Score = 135 bits (339), Expect = 5e-31
Identities = 82/231 (35%), Positives = 97/231 (41%), Gaps = 26/231 (11%)
Query: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVF 967
W SECS+ CG G + C D C +P CH
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR----------DEDCAPAGRPQPARRCHLRPCA 1464
Query: 968 TRWHYSEWSQCSRSCGGGERSRESYCMNNFGHR-LADNECQE--LSRVTRENCNEFSCPS 1024
T WH WS+CSRSCGGG R+ C++ R L CQ C C S
Sbjct: 1465 T-WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS 1523
Query: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGP 1084
W S W EC CG G +QR V C G C + +P + PC H C W VGP
Sbjct: 1524 WYTSSWRECSEACGGGEQQRLVTCP------EPGLCEEALRPNTTRPCNTHPCTQWVVGP 1577
Query: 1085 WGPCTTTCGHGYQMRDVKCVNELASAVLEDT-EC-HEA----SRPSDRQSC 1129
WG C+ CG G Q R VKCVN ED+ +C HEA SRP + C
Sbjct: 1578 WGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 132 bits (331), Expect = 4e-30
Identities = 77/239 (32%), Positives = 99/239 (41%), Gaps = 52/239 (21%)
Query: 1149 LIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDC-FTP 1207
L+ + A W+ G+W+ CS +CG G R V C D CA RP C P
Sbjct: 1408 LVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDED-----CAPAGRPQPARRCHLRP 1462
Query: 1208 CGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLA-ACPPA 1266
C W +G+WS CS SCG G + R V C++ ++RPL C A PPA
Sbjct: 1463 CATWHSGNWSKCSRSCGGGSSVRDVQCVDTR----------DLRPLRPFHCQPGPAKPPA 1512
Query: 1267 HSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQH 1326
H + P W T W CS +C GG Q
Sbjct: 1513 HRPCGAQPCL------------------------------SWYTSSWRECSEACGGGEQQ 1542
Query: 1327 RAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVIC 1385
R V C + C+ A +P + C PC QW G WG+CS CGGG++ RLV C
Sbjct: 1543 RLVTCPE-----PGLCEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGVQRRLVKC 1596
Score = 130 bits (327), Expect = 1e-29
Identities = 98/329 (29%), Positives = 134/329 (40%), Gaps = 37/329 (11%)
Query: 1248 PEVRPLMEQECSLAACPPAHSHFP-----SSPVQPSYYLSTNLPLTQK-LEDNENQVVHP 1301
P + PL E + ++ P FP S +Q T LP T L ++P
Sbjct: 1295 PPIAPLPEMKVRDSSLEPGTPSFPTPGPGSWDLQTVAVWGTFLPTTLTGLGHMPEPALNP 1354
Query: 1302 SVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQ 1361
+G P SS + D S + P L + GP P
Sbjct: 1355 GPKGQPESLSPEVPLSSRLL------STPAWDSPANSHRVPETQPLAPSLAEAGPPADPL 1408
Query: 1362 ------WNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
W GNW ECS TCG G R V C +G+ D +C +P +CH+ C
Sbjct: 1409 VVRNAGWQAGNWSECSTTCGLGAVWRPVRCS--SGR---DEDCAPAGRPQPARRCHLRPC 1463
Query: 1416 PADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQ-RKLEDTNCSQ-VQKPPTHKACRSVR 1473
+WH W+ CS SCG G R+V C+D R L +C KPP H+ C +
Sbjct: 1464 ---ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQP 1520
Query: 1474 CPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQH 1533
C SW +SW ECS CG G QQR V C G +C+++ RP + R C + C Q
Sbjct: 1521 CLSWYTSSWRECSEACGGGEQQRLVTCPEPG-------LCEEALRPNTTRPCNTHPCTQW 1573
Query: 1534 KGMERGRLNCSTSCERKDSHQRMECTDNQ 1562
G+ CS C + ++C + Q
Sbjct: 1574 VVGPWGQ--CSGPCGGGVQRRLVKCVNTQ 1600
Score = 120 bits (302), Expect = 1e-26
Identities = 82/270 (30%), Positives = 105/270 (38%), Gaps = 62/270 (22%)
Query: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHF 1270
WQAG+WS CS +CG G R V C + DE+ C P RP + C L C
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGR---DED-CAPAGRPQPARRCHLRPCAT----- 1465
Query: 1271 PSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVV 1330
W +G W CS SC GG R V
Sbjct: 1466 -------------------------------------WHSGNWSKCSRSCGGGSSVRDVQ 1488
Query: 1331 CQDENGQSAS---YCDAA-SKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQ 1386
C D +C +KPP + CG PC W +W ECS+ CGGG + RLV C
Sbjct: 1489 CVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCP 1548
Query: 1387 FPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCID 1446
P CE +P + C+ H C W PW CS CG G + R V C++
Sbjct: 1549 EPG-------LCEEALRPNTTRPCNTHPC---TQWVVGPWGQCSGPCGGGVQRRLVKCVN 1598
Query: 1447 -QFQRKLEDTN-CSQVQKPPTHKACRSVRC 1474
Q ED++ C P + + C + C
Sbjct: 1599 TQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 118 bits (296), Expect = 5e-26
Identities = 80/289 (27%), Positives = 103/289 (35%), Gaps = 80/289 (27%)
Query: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFI 1137
A WQ G W C+TTCG G R V+C + D +C A RP + C L PC
Sbjct: 1413 AGWQAGNWSECSTTCGLGAVWRPVRCSSG------RDEDCAPAGRPQPARRCHLRPC--- 1463
Query: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD-RIADESYCAHLP 1196
A W G+W+ CS SCG G+ R V C D D R +C P
Sbjct: 1464 ----------------ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGP 1507
Query: 1197 -RPAEIWDC-FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLM 1254
+P C PC W W CS +CG G+ R V C + C+ +RP
Sbjct: 1508 AKPPAHRPCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCP------EPGLCEEALRPNT 1561
Query: 1255 EQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWG 1314
+ C+ C QW GPWG
Sbjct: 1562 TRPCNTHPC------------------------------------------TQWVVGPWG 1579
Query: 1315 SCSSSCSGGLQHRAVVCQDEN----GQSASYCDAASKPPELQQCGPGPC 1359
CS C GG+Q R V C + + + C + P + CG C
Sbjct: 1580 QCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC 1628
Score = 110 bits (275), Expect = 1e-23
Identities = 61/178 (34%), Positives = 88/178 (49%), Gaps = 15/178 (8%)
Query: 1356 PGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKP-PSVIQCHMHA 1414
P P W+YG W +C+ TCG G++ + V C +++ +C+ + +P +C
Sbjct: 819 PPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQP 878
Query: 1415 CPADVSWHQEPWTSCSASCGK-GRKYREVFCIDQF----QRKLEDTNCSQVQKPPTHKAC 1469
CPA W W CS+SCG G R V CI Q LE C + +PPT C
Sbjct: 879 CPA--RWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPC 936
Query: 1470 -RSVRCP-SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRC 1525
R V CP +W +W++CSVTCG G Q+R+V C CD++ +P S+ C
Sbjct: 937 NRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCT-----NDTGVPCDEAQQPASEVTC 989
Score = 108 bits (269), Expect = 7e-23
Identities = 78/262 (29%), Positives = 97/262 (37%), Gaps = 47/262 (17%)
Query: 955 PPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVT- 1013
PP L N W WS+CS +CG G R C + D +C R
Sbjct: 1403 PPADPLVVRNA---GWQAGNWSECSTTCGLGAVWRPVRCSSG-----RDEDCAPAGRPQP 1454
Query: 1014 RENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVD--HLSDGFCNSS-TKPESLS 1070
C+ C +W + WS+C +CG G+ R V C D L C KP +
Sbjct: 1455 ARRCHLRPCATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHR 1514
Query: 1071 PCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCV 1130
PC C SW W C+ CG G Q R V C E C EA RP+ + C
Sbjct: 1515 PCGAQPCLSWYTSSWRECSEACGGGEQQRLVTCP--------EPGLCEEALRPNTTRPCN 1566
Query: 1131 LTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADE- 1189
PC+ QW G W CS CG G Q R V C + + +E
Sbjct: 1567 THPCT-------------------QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEED 1607
Query: 1190 -SYCAHLPRPAEIW-DCFTPCG 1209
C H E W + PCG
Sbjct: 1608 SDQCGH-----EAWPESSRPCG 1624
Score = 107 bits (268), Expect = 9e-23
Identities = 69/195 (35%), Positives = 82/195 (42%), Gaps = 34/195 (17%)
Query: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQ-SCVLTPCSFI 1137
SW GPW CT TCG G Q ++V C+ A V ++ C RP D+Q C PC
Sbjct: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPV-DEEHCDPLGRPDDQQRKCSEQPCP-- 880
Query: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCG-RGTQARYVSCRDAL----DRIADESYC 1192
A+W G W CS SCG G R V C ++ + C
Sbjct: 881 ----------------ARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPAC 924
Query: 1193 AHLPRPAEIWDC--FTPC-GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENY-CDP 1248
HLPRP C PC W G+WS CS +CG G R VLC N D CD
Sbjct: 925 EHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTN-----DTGVPCDE 979
Query: 1249 EVRPLMEQECSLAAC 1263
+P E CSL C
Sbjct: 980 AQQPASEVTCSLPLC 994
Score = 106 bits (265), Expect = 2e-22
Identities = 63/195 (32%), Positives = 91/195 (46%), Gaps = 27/195 (13%)
Query: 951 DQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELS 1010
D++ PP VF+ WHY W++C+ +CG G + + YC+ + + C L
Sbjct: 816 DEVPPP---------VFS-WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLG 865
Query: 1011 RVT--RENCNEFSCPS-WAASEWSECLVTCGKG-TKQRQVWCQLNV-----DHLSDGFCN 1061
R + C+E CP+ W A EW C +CG G +R V C +V L C
Sbjct: 866 RPDDQQRKCSEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACE 925
Query: 1062 SSTKPESLSPCELHT-C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHE 1119
+P + +PC H C A+W VG W C+ TCG G Q R+V C N+ C E
Sbjct: 926 HLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTG------VPCDE 979
Query: 1120 ASRPSDRQSCVLTPC 1134
A +P+ +C L C
Sbjct: 980 AQQPASEVTCSLPLC 994
Score = 99.8 bits (247), Expect = 2e-20
Identities = 64/220 (29%), Positives = 87/220 (39%), Gaps = 57/220 (25%)
Query: 1207 PCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQ-PIDENYCDPEVRPLMEQ-ECSLAACP 1264
P W G W+ C+ +CG G + V C+ P+DE +CDP RP +Q +CS CP
Sbjct: 821 PVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCP 880
Query: 1265 PAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCS-GG 1323
+W G W CSSSC GG
Sbjct: 881 A-----------------------------------------RWWAGEWQLCSSSCGPGG 899
Query: 1324 LQHRAVVC------QDENGQSASYCDAASKPPELQQCGPG-PCP-QWNYGNWGECSQTCG 1375
L RAV+C +++ C+ +PP C PCP W GNW +CS TCG
Sbjct: 900 LSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCG 959
Query: 1376 GGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
G + R V+C G C+ +P S + C + C
Sbjct: 960 EGTQRRNVLCTNDTGV-----PCDEAQQPASEVTCSLPLC 994
Score = 96.3 bits (238), Expect = 3e-19
Identities = 69/217 (31%), Positives = 89/217 (41%), Gaps = 43/217 (19%)
Query: 1156 WRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIW-DCF-TPC-GEWQ 1212
W +G WT C+V+CGRG Q + V C + DE +C L RP + C PC W
Sbjct: 825 WHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWW 884
Query: 1213 AGDWSPCSASCGHGKTTRQ-VLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFP 1271
AG+W CS+SCG G +R+ VLC +R + E S A PPA H P
Sbjct: 885 AGEWQLCSSSCGPGGLSRRAVLC---------------IRSVGLDEQS-ALEPPACEHLP 928
Query: 1272 SSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVC 1331
P + P T W G W CS +C G Q R V+C
Sbjct: 929 RPPTETPCNRHVPCPAT-------------------WAVGNWSQCSVTCGEGTQRRNVLC 969
Query: 1332 QDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWG 1368
++ G CD A +P C C +W G G
Sbjct: 970 TNDTGVP---CDEAQQPASEVTCSLPLC-RWPLGTLG 1002
Score = 95.5 bits (236), Expect = 4e-19
Identities = 73/246 (29%), Positives = 105/246 (42%), Gaps = 33/246 (13%)
Query: 1472 VRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCV 1531
VR W+A +W+ECS TCG G R V C +E C + RP RRC + C
Sbjct: 1410 VRNAGWQAGNWSECSTTCGLGAVWRPVRC-----SSGRDEDCAPAGRPQPARRCHLRPCA 1464
Query: 1532 Q-HKGMERGRLNCSTSCERKDSHQRMECTDNQ-IRQVNEIVYNSSTISLTS-KNCRNPPC 1588
H G CS SC S + ++C D + +R + + + C PC
Sbjct: 1465 TWHSG---NWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPC 1521
Query: 1589 NYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQC 1648
T+ +C+ CG +QR+ C E ++ LRP + C P +Q
Sbjct: 1522 -LSWYTSSWRECSEACGGGEQQRLVTCPEPGLCEE----ALRPNTTRPCNTHPCTQ---- 1572
Query: 1649 INSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCI-TKHGL---SSDLCLNHLKPGAQKKC 1704
W VG W +CS CG G+ +R VKC+ T+ GL SD C + P + + C
Sbjct: 1573 ---------WVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPC 1623
Query: 1705 YANDCK 1710
DC+
Sbjct: 1624 GTEDCE 1629
Score = 77.0 bits (188), Expect = 2e-13
Identities = 46/184 (25%), Positives = 82/184 (44%), Gaps = 9/184 (4%)
Query: 1411 HMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKP-PTHKAC 1469
H P SWH PWT C+ +CG+G + + V+C+++ +++ +C + +P + C
Sbjct: 815 HDEVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKC 874
Query: 1470 RSVRCPS-WKANSWNECSVTCG-SGVQQRDVYCRLKGVG-----QVVEEMCDQSTRPCSQ 1522
CP+ W A W CS +CG G+ +R V C ++ VG + C+ RP ++
Sbjct: 875 SEQPCPARWWAGEWQLCSSSCGPGGLSRRAVLC-IRSVGLDEQSALEPPACEHLPRPPTE 933
Query: 1523 RRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKN 1582
C CS +C + + CT++ +E +S ++ +
Sbjct: 934 TPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVLCTNDTGVPCDEAQQPASEVTCSLPL 993
Query: 1583 CRNP 1586
CR P
Sbjct: 994 CRWP 997
Score = 67.4 bits (163), Expect = 1e-10
Identities = 45/148 (30%), Positives = 62/148 (41%), Gaps = 8/148 (5%)
Query: 1476 SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRP-CSQRRCWSQDCVQHK 1534
SW W +C+VTCG GVQ+++VYC + G V EE CD RP QR+C Q C
Sbjct: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARW 883
Query: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIV-- 1592
+L CS+SC +R + + + PCN V
Sbjct: 884 WAGEWQL-CSSSCGPGGLSRRAVLCIRSVGLDEQSALEPPACEHLPRPPTETPCNRHVPC 942
Query: 1593 ----VTADSSQCANNCGFSYRQRITYCT 1616
+ SQC+ CG ++R CT
Sbjct: 943 PATWAVGNWSQCSVTCGEGTQRRNVLCT 970
Score = 65.1 bits (157), Expect = 6e-10
Identities = 56/229 (24%), Positives = 80/229 (34%), Gaps = 35/229 (15%)
Query: 849 TWDPYGPWEGCTKMCQGLQR-RNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELR 907
TW G W C++ C G R++ C+ D + C P + C L
Sbjct: 1465 TWHS-GNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS 1523
Query: 908 WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVF 967
W+ ECS CG G + + C + + C + L+P T C+ +
Sbjct: 1524 WYTSSWRECSEACGGGEQQRLVTCPEPGL------------CEEALRPNTTRPCNTH-PC 1570
Query: 968 TRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAA 1027
T+W W QCS CGGG + R C+N T+ E
Sbjct: 1571 TQWVVGPWGQCSGPCGGGVQRRLVKCVN-----------------TQTGLPEEDSDQCGH 1613
Query: 1028 SEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHT 1076
W E CG + + D LS GFC + L C+L T
Sbjct: 1614 EAWPESSRPCGTEDCEPVEPPRCERDRLSFGFCETL---RLLGRCQLPT 1659
Score = 57.8 bits (138), Expect = 1e-07
Identities = 45/170 (26%), Positives = 67/170 (39%), Gaps = 9/170 (5%)
Query: 1543 CSTSCERKDSHQRMECTDNQIRQVNEIVYNS-STISLTSKNCRNPPCNYIVVTADSSQCA 1601
C+ +C R Q + C + Q V+E + + C PC + C+
Sbjct: 833 CTVTCGRGVQRQNVYCLERQAGPVDEEHCDPLGRPDDQQRKCSEQPCPARWWAGEWQLCS 892
Query: 1602 NNCG-FSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKV 1660
++CG +R C I S + L P + P P+ C ATW V
Sbjct: 893 SSCGPGGLSRRAVLC--IRSVGLDEQSALEPPACEHLPRPPTET--PCNRHVPCPATWAV 948
Query: 1661 GKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDCK 1710
G WS+CSVTCG G +R V C G+ C +P ++ C C+
Sbjct: 949 GNWSQCSVTCGEGTQRRNVLCTNDTGVP---CDEAQQPASEVTCSLPLCR 995
Score = 46.2 bits (108), Expect = 3e-04
Identities = 40/140 (28%), Positives = 55/140 (39%), Gaps = 27/140 (19%)
Query: 1586 PPCNYIVV------TADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPV 1639
PP + +VV + S+C+ CG R C+ R +P + C +
Sbjct: 1403 PPADPLVVRNAGWQAGNWSECSTTCGLGAVWRPVRCSSGRDEDCAPAGRPQPA--RRCHL 1460
Query: 1640 VPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPG 1699
P ATW G WSKCS +CG G R V+C+ L L H +PG
Sbjct: 1461 RPC-------------ATWHSGNWSKCSRSCGGGSSVRDVQCVDTRDL-RPLRPFHCQPG 1506
Query: 1700 -----AQKKCYANDCKSFTT 1714
A + C A C S+ T
Sbjct: 1507 PAKPPAHRPCGAQPCLSWYT 1526
Score = 40.4 bits (93), Expect = 0.017
Identities = 19/58 (32%), Positives = 28/58 (48%), Gaps = 7/58 (12%)
Query: 1657 TWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKP-----GAQKKCYANDC 1709
+W G W+KC+VTCG G+ ++ V C+ + D H P Q+KC C
Sbjct: 824 SWHYGPWTKCTVTCGRGVQRQNVYCLERQAGPVD--EEHCDPLGRPDDQQRKCSEQPC 879
Score = 33.1 bits (74), Expect = 2.7
Identities = 20/60 (33%), Positives = 25/60 (41%), Gaps = 4/60 (6%)
Query: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHF 1270
W A WS CS SCG G + + C YC E + + C+L ACP F
Sbjct: 544 WSA--WSICSRSCGMGVQSAERQCTQPTPKYKGRYCVGERKRF--RLCNLQACPAGRPSF 599
Score = 33.1 bits (74), Expect = 2.7
Identities = 36/129 (27%), Positives = 47/129 (36%), Gaps = 18/129 (13%)
Query: 487 KQCELAFGPGSQM----CPHINICMH-LWCTSTEKLHKGCFTQHVPPADGT---DCGPGM 538
++C A G G Q CP +C L +T + TQ V G CG G+
Sbjct: 1530 RECSEACGGGEQQRLVTCPEPGLCEEALRPNTTRPCNTHPCTQWVVGPWGQCSGPCGGGV 1589
Query: 539 HCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGR 598
R CVN +T + + E + SR CG T C EP C
Sbjct: 1590 QRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCG------TEDCEPVEPPR----CERD 1639
Query: 599 RMKFRSCNT 607
R+ F C T
Sbjct: 1640 RLSFGFCET 1648
Score = 32.3 bits (72), Expect = 4.5
Identities = 24/81 (29%), Positives = 32/81 (39%), Gaps = 16/81 (19%)
Query: 543 GLCVN--KETETRPVNG----EW--GPWEPYSSCSRTCGGGIESATRRCNRPE---PRNG 591
GLC + TRP N +W GPW CS CGGG++ +C + P
Sbjct: 1551 GLCEEALRPNTTRPCNTHPCTQWVVGPW---GQCSGPCGGGVQRRLVKCVNTQTGLPEED 1607
Query: 592 GNYCVGRRM--KFRSCNTDSC 610
+ C R C T+ C
Sbjct: 1608 SDQCGHEAWPESSRPCGTEDC 1628
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 505 bits (1300), Expect = e-142
Identities = 336/1132 (29%), Positives = 534/1132 (47%), Gaps = 104/1132 (9%)
Query: 40 YEVVIPERVNEFGE-VFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNLTADAS 98
Y++V V+ G+ V + H R++R+ E H R F ++L +S
Sbjct: 60 YDLVSAYEVDHRGDYVSHEIMHHQRRRRAVPVSEVESL--HLRLKGSRHDFHMDLRTSSS 117
Query: 99 FLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQ 158
+A G+ LG + ++ P D CFY+G + S + +S C GL+G + +
Sbjct: 118 LVAPGFIVQTLGKTGTKSVQT-LPPEDF--CFYQGSLRSHRNSSVALSTCQGLSGMIRTE 174
Query: 159 NGEYFLEPI---MKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKYCSVSESQIKETSLPF 215
+YFL P+ + G + H++Y++ V+ + P
Sbjct: 175 EADYFLRPLPSHLSWKLGRAAQGSSPSHVLYKRS-TEPHAPGASEVLVTSRTWELAHQPL 233
Query: 216 HTYSNMNEDLNV---MKERVLGHTSKNVP---------LKDERRHS--RKKRLISYPRY- 260
H+ DL + K+ G K +P L DE + K+ L+ R
Sbjct: 234 HS-----SDLRLGLPQKQHFCGRRKKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNE 288
Query: 261 ---IEIMVTADAKVVSAHG-SNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHRE 316
+E +V D K++ HG N+ Y+LT++++V+ ++KD +IG I+I +V L+++ E
Sbjct: 289 ELNVETLVVVDKKMMQNHGHENITTYVLTILNMVSALFKDGTIGGNINIAIVGLILLEDE 348
Query: 317 EEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSK-EKCNMLGLS 375
+ G VI+ TL +FC WQ D + HD A+L+T DICS K E C+ LG +
Sbjct: 349 QPGLVISHHADHTLSSFCQWQSGLMGKDG---TRHDHAILLTGLDICSWKNEPCDTLGFA 405
Query: 376 YLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKEMKVTKYHVMAPAL 434
+ +C +SC INE+ GL AFTIAHE GH G+ HD + CK+ ++ ++M+P L
Sbjct: 406 PISGMCSKYRSCTINEDTGLGLAFTIAHESGHNFGMIHDGEGNMCKK---SEGNIMSPTL 462
Query: 435 SFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDE-EIYNLPSELPGSRYDGNKQCELAF 493
+ +SWS CSR+Y+ +FL T CL D+P + Y P +LPG YD N QC+ F
Sbjct: 463 AGRNGVFSWSPCSRQYLHKFLSTAQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQF 522
Query: 494 GPGSQMCP---HINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKET 550
G +++C +IC LWC ++ + C T+ +P A+GT CG M CR G CV
Sbjct: 523 GEKAKLCMLDFKKDICKALWC---HRIGRKCETKFMPAAEGTICGHDMWCRGGQCVKYGD 579
Query: 551 E-TRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDS 609
E +P +G W W +S CSRTCGGG+ +R C P+P +GG +C G + CN+
Sbjct: 580 EGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQK 639
Query: 610 CPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLL 669
CP+ + DFR QC++ N + + +W P Y+ + +D CKLYC G ++F+ L
Sbjct: 640 CPRDSVDFRAAQCAEHNSRRFR----GRHYKWKP-YTQVEDQDLCKLYCIAEGFDFFFSL 694
Query: 670 KDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNS 729
+ V+DGTPC ++ ++C+ G C GCD+VL S A D CGVC G+NS+C G++
Sbjct: 695 SNKVKDGTPCSEDSRNVCIDGICERVGCDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTK 754
Query: 730 SHY--GYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEI 787
H+ Y +V IP+GA ++ I + + S SY+++ +A + NG++ + +
Sbjct: 755 HHHTNQYYHMVTIPSGARSIRIYEMNVS----TSYISVRNALRRYYLNGHWTVDWPGR-- 808
Query: 788 NVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDM 847
+ + T +Y S N E + +T + LI+++L G NP V + +++P
Sbjct: 809 -YKFSGTTFDYRRSYNEPENLIATGPTNETLIVELLFQGR--NPGVAWEYSMPRLGTEKQ 865
Query: 848 FTWDPYGPW----EGCTKMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTD 903
P W C+ C G Q ++ V+ C+ P C
Sbjct: 866 PPAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVS 925
Query: 904 -CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCH 962
C W V S CS CG G ++ + C + ++ + V C Q P +++ C+
Sbjct: 926 ACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPAS--LC-PQPAPSSRQACN 982
Query: 963 GNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNN----FGHRLADNECQELSR------V 1012
W W++CS +CG G R R C + L D C +
Sbjct: 983 SQSCPPAWSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEAC 1042
Query: 1013 TRENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWC-----QLNVDHLSDGFCNSSTKPE 1067
+ C++ W S WS+C VTC +GT++R + C L+ C+ KP
Sbjct: 1043 LLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPS 1102
Query: 1068 -------SLSPCELH--------TCASWQVGPWGPCTTTCGHGYQMRDVKCV 1104
+ PC H + SW PW CT +CG G Q R V+C+
Sbjct: 1103 LELERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCL 1154
Score = 149 bits (377), Expect = 2e-35
Identities = 100/321 (31%), Positives = 139/321 (43%), Gaps = 46/321 (14%)
Query: 976 SQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRE--NCNEFSCP-SWAASEWSE 1032
S+CS SCGGG+ + C + ++ + C +R C +CP SW+ WS
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSA 938
Query: 1033 CLVTCGKGTKQRQVWCQLNVDHLSDGFCNS---STKPESLSPCELHTCA-SWQVGPWGPC 1088
C TCG G + R V C V + S+ S P S C +C +W GPW C
Sbjct: 939 CSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAEC 998
Query: 1089 TTTCGHGYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSCVLTPCSFISKLETALL 1145
+ TCG G++ R V C + SA +L D C +P ++C+L C KL
Sbjct: 999 SHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKL----- 1053
Query: 1146 PTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRD----ALDRIADESYCAHLPRPA-- 1199
QW +W+ CSV+C RGTQ R++ C + R C+HLP+P+
Sbjct: 1054 ---------QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLE 1104
Query: 1200 -EIWDCFTPC-------------GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENY 1245
E PC G W A WS C+ASCG G TR V C+ +P +
Sbjct: 1105 LERACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRP--ASG 1162
Query: 1246 CDPEVRPLMEQECSLAACPPA 1266
C +P C+ CP A
Sbjct: 1163 CLLHQKPSASLACNTHFCPIA 1183
Score = 143 bits (361), Expect = 1e-33
Identities = 94/321 (29%), Positives = 133/321 (41%), Gaps = 75/321 (23%)
Query: 1217 SPCSASCGHGK-TTRQVLCMNYHQPIDENYCDPEVRPLMEQ-ECSLAACPPAHSHFPSSP 1274
S CS SCG G+ T R+ + ++ ++C+P+ RP+ C ++ACPP+
Sbjct: 879 SECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPS-------- 930
Query: 1275 VQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ-- 1332
W G W +CS +C GG Q R V C
Sbjct: 931 ---------------------------------WSVGNWSACSRTCGGGAQSRPVQCTRR 957
Query: 1333 ---DENGQSASYCDAASKPPELQQCGPGPCPQ-WNYGNWGECSQTCGGGIKSRLVICQFP 1388
D AS C + P Q C CP W+ G W ECS TCG G + R V C+
Sbjct: 958 VHYDSEPVPASLCPQPA-PSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRKRAVACKST 1016
Query: 1389 N----GQILEDHNCEIVNKPPSVIQCHMHAC--PADVSWHQEPWTSCSASCGKGRKYREV 1442
N Q+L D C KP C + C P + W W+ CS +C +G + R +
Sbjct: 1017 NPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFL 1076
Query: 1443 FCIDQF----QRKLEDTNCSQVQKPPTH--KACRSVRCP-------------SWKANSWN 1483
C +++ R+L CS + KP +AC + CP SW A+ W+
Sbjct: 1077 KCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPWS 1136
Query: 1484 ECSVTCGSGVQQRDVYCRLKG 1504
+C+ +CG GVQ R V C G
Sbjct: 1137 QCTASCGGGVQTRSVQCLAGG 1157
Score = 125 bits (314), Expect = 4e-28
Identities = 97/349 (27%), Positives = 135/349 (38%), Gaps = 85/349 (24%)
Query: 1164 CSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPCG------EWQAGDWS 1217
CSVSCG G C L + S+C RP PC W G+WS
Sbjct: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVT---GLVPCKVSACPPSWSVGNWS 937
Query: 1218 PCSASCGHGKTTRQVLC---MNYH-QPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSS 1273
CS +CG G +R V C ++Y +P+ + C P+ P Q C+ +CPPA
Sbjct: 938 ACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLC-PQPAPSSRQACNSQSCPPA------- 989
Query: 1274 PVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQD 1333
W GPW CS +C G + RAV C+
Sbjct: 990 ----------------------------------WSAGPWAECSHTCGKGWRKRAVACKS 1015
Query: 1334 ENGQSA------SYCDAASKPPE-----LQQCGPGPCPQWNYGNWGECSQTCGGGIKSRL 1382
N + + C + KP LQ+C QW W +CS TC G + R
Sbjct: 1016 TNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRF 1075
Query: 1383 VIC--QFPNGQI--LEDHNCEIVNKPP-------SVIQCHMH-----ACPADVSWHQEPW 1426
+ C ++ +G+ L C + KP + + C H A P+ SW PW
Sbjct: 1076 LKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHPPFAAAGPSRGSWFASPW 1135
Query: 1427 TSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP 1475
+ C+ASCG G + R V C+ + + C QKP AC + CP
Sbjct: 1136 SQCTASCGGGVQTRSVQCLAGGR---PASGCLLHQKPSASLACNTHFCP 1181
Score = 117 bits (292), Expect = 1e-25
Identities = 87/275 (31%), Positives = 122/275 (44%), Gaps = 34/275 (12%)
Query: 1316 CSSSCSGGLQHRAVVC-QDENGQ-SASYCDAASKPPE-LQQCGPGPCP-QWNYGNWGECS 1371
CS SC GG C +D Q + S+C+ ++P L C CP W+ GNW CS
Sbjct: 881 CSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPPSWSVGNWSACS 940
Query: 1372 QTCGGGIKSRLVICQFPNGQILEDHNCEIVNKP-PSVIQ-CHMHACPADVSWHQEPWTSC 1429
+TCGGG +SR V C E + +P PS Q C+ +CP +W PW C
Sbjct: 941 RTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPP--AWSAGPWAEC 998
Query: 1430 SASCGKGRKYREVFC----IDQFQRKLEDTNCSQVQKPPTHKACRSVRCP-----SWKAN 1480
S +CGKG + R V C + L D C+ KP H+AC RC W +
Sbjct: 999 SHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLVS 1058
Query: 1481 SWNECSVTCGSGVQQRDVYCRLKGVG----QVVEEMCDQSTRPC--SQRRCWSQDCVQH- 1533
+W++CSVTC G Q+R + C K V ++ + C +P +R C C +H
Sbjct: 1059 AWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLPCPRHP 1118
Query: 1534 ----KGMERGR------LNCSTSCERKDSHQRMEC 1558
G RG C+ SC + ++C
Sbjct: 1119 PFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQC 1153
Score = 108 bits (271), Expect = 4e-23
Identities = 91/364 (25%), Positives = 136/364 (37%), Gaps = 66/364 (18%)
Query: 1369 ECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKP-PSVIQCHMHACPADVSWHQEPWT 1427
ECS +CGGG + C + C +P ++ C + ACP SW W+
Sbjct: 880 ECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSACPP--SWSVGNWS 937
Query: 1428 SCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQK--PPTHKACRSVRC-PSWKANSWNE 1484
+CS +CG G + R V C + E S + P + +AC S C P+W A W E
Sbjct: 938 ACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAE 997
Query: 1485 CSVTCGSGVQQRDVYCRLKGVGQ----VVEEMCDQSTRPCSQRRCWSQDCVQHKGME--- 1537
CS TCG G ++R V C+ + + +C +P C Q C + K ++
Sbjct: 998 CSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQWLV 1057
Query: 1538 RGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADS 1597
CS +CER + ++C + + + L SK C + P
Sbjct: 1058 SAWSQCSVTCERGTQKRFLKCAEKYV--------SGKYRELASKKCSHLP---------- 1099
Query: 1598 SQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLAT 1657
K L R CP P + +
Sbjct: 1100 -------------------------KPSLELERACAPLPCPRHPPFAA-----AGPSRGS 1129
Query: 1658 WKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC----KSFT 1713
W WS+C+ +CG G+ R V+C+ G + CL H KP A C + C K
Sbjct: 1130 WFASPWSQCTASCGGGVQTRSVQCLA-GGRPASGCLLHQKPSASLACNTHFCPIAEKKDA 1188
Query: 1714 TCKE 1717
CK+
Sbjct: 1189 FCKD 1192
Score = 59.7 bits (143), Expect = 3e-08
Identities = 62/245 (25%), Positives = 98/245 (40%), Gaps = 25/245 (10%)
Query: 1475 PSWKANSW----NECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQR-RCWSQD 1529
P+ + +W +ECSV+CG G C QV C+ TRP + C
Sbjct: 867 PAQPSYTWAIVRSECSVSCGGGQMTVREGCYRDLKFQVNMSFCNPKTRPVTGLVPCKVSA 926
Query: 1530 CVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNS---STISLTSKNCRNP 1586
C + CS +C + ++CT ++ +E V S + + C +
Sbjct: 927 CPPSWSVGNWSA-CSRTCGGGAQSRPVQCT-RRVHYDSEPVPASLCPQPAPSSRQACNSQ 984
Query: 1587 PCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVY 1646
C ++C++ CG +R+R C ST +L P C P +++
Sbjct: 985 SCPPAWSAGPWAECSHTCGKGWRKRAVACK---STNPSARAQLLPDAV--CTSEPKPRMH 1039
Query: 1647 Q-CINSCLHLAT---WKVGKWSKCSVTCGIGIMKRQVKCITKH------GLSSDLCLNHL 1696
+ C+ H W V WS+CSVTC G KR +KC K+ L+S C +
Sbjct: 1040 EACLLQRCHKPKKLQWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLP 1099
Query: 1697 KPGAQ 1701
KP +
Sbjct: 1100 KPSLE 1104
Score = 39.3 bits (90), Expect = 0.037
Identities = 28/107 (26%), Positives = 42/107 (39%), Gaps = 14/107 (13%)
Query: 1336 GQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILED 1395
GQ Y D KP G W+ +W CS+TCGGG+ R +C P
Sbjct: 572 GQCVKYGDEGPKPTH------GHWSDWS--SWSPCSRTCGGGVSHRSRLCTNPK----PS 619
Query: 1396 HNCEIVNKPPSVIQ-CHMHACPAD-VSWHQEPWTSCSASCGKGRKYR 1440
H + ++ C+ CP D V + ++ +GR Y+
Sbjct: 620 HGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRGRHYK 666
Score = 38.9 bits (89), Expect = 0.049
Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 3/57 (5%)
Query: 1209 GEWQA-GDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACP 1264
G W WSPCS +CG G + R LC N +C+ R L + C+ CP
Sbjct: 587 GHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTL--KLCNSQKCP 641
Score = 36.2 bits (82), Expect = 0.32
Identities = 14/50 (28%), Positives = 27/50 (54%), Gaps = 3/50 (6%)
Query: 1313 WGSCSSSCSGGLQHRAVVCQD-ENGQSASYCDAASKPPELQQCGPGPCPQ 1361
W CS +C GG+ HR+ +C + + +C+ +++ L+ C CP+
Sbjct: 595 WSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTR--TLKLCNSQKCPR 642
Score = 32.3 bits (72), Expect = 4.5
Identities = 19/51 (37%), Positives = 25/51 (49%), Gaps = 3/51 (5%)
Query: 1480 NSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
+SW+ CS TCG GV R C + C+ STR + + C SQ C
Sbjct: 593 SSWSPCSRTCGGGVSHRSRLCTNPKPSH-GGKFCEGSTR--TLKLCNSQKC 640
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 455 bits (1171), Expect = e-127
Identities = 315/1038 (30%), Positives = 484/1038 (46%), Gaps = 103/1038 (9%)
Query: 81 RFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRH----CFYRGQVN 136
R A+ + L L D FLA + P G + + P CFY G V
Sbjct: 168 RIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTGAASAPQPPAPPDAGCFYTGAVL 227
Query: 137 SQEDYKAVVSLCGG-LTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFL 195
A S CGG L G + F+EP+ N+ PH +YRQ +
Sbjct: 228 RHPGSLASFSTCGGGLMGFIQLNEDFIFIEPL-----NDTMAITGHPHRVYRQKRS---- 278
Query: 196 QTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLI 255
E ++ E S Y + D + R + + + +R+S K +
Sbjct: 279 --------MEEKVTEKSALHSHYCGIISDKGRPRSRKIAESGRG------KRYSYK---L 321
Query: 256 SYPRYIEIMVTADAKVVSAHGSNL-QNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIH 314
IE +V AD +VS HG++ + +ILT++++V +++ S+ +++ V+KL+++H
Sbjct: 322 PQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLRVIKLILLH 381
Query: 315 REEEGPVINFDGATTLKNFCSWQQTQ-NDLDDVH----------PSHHDTAVLITREDIC 363
I G L++FC WQ + +D+H + D A+LITR+D C
Sbjct: 382 ETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDAAILITRKDFC 441
Query: 364 SSK-EKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKE 421
K E C+ +G++YL +C + C I E+ GL AFTIAHE+GH +G+ HD D+P C +
Sbjct: 442 VHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGINHDNDHPSCAD 501
Query: 422 MKVTKYHVMAPAL--SFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNL--PSE 477
H+M+ ++ SWS CS++ + FL + CLL + + ++ PS+
Sbjct: 502 ----GLHIMSGEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSK 557
Query: 478 LPGSRYDGNKQCELAFGPGSQMCPHIN--ICMHLWCTSTEKLHKGCFTQHVPPADGTDCG 535
LPG Y ++QC++ FGP + C + IC LWC + K C T+ PP DGTDC
Sbjct: 558 LPGMTYTADEQCQILFGPLASFCQEMQHVICTGLWCKVEGE--KECRTKLDPPMDGTDCD 615
Query: 536 PGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC 595
G C+ G C ++ + + GEW W P CSRTC GI S R+C P + C
Sbjct: 616 LGKWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC--PGLDSEARDC 670
Query: 596 VGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDR-C 654
G R ++R C CP G FR+ QC ++ + S+ + + ++ + +++ C
Sbjct: 671 NGPRKQYRICENPPCPAGLPGFRDWQCQAYSVR-------TSSPKHILQWQAVLDEEKPC 723
Query: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
L+C G LL + V DGT CG + DIC G+C GCD +L S A+ D CGVC
Sbjct: 724 ALFCSPVGKEQPILLSEKVMDGTSCGYQGLDICANGRCQKVGCDGLLGSLAREDHCGVCN 783
Query: 715 GDNSSCKTITGVFNSSH-YGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFL 773
G+ SCK I G FN + GY V+ IPAGA + + +P SYLAL DA G
Sbjct: 784 GNGKSCKIIKGDFNHTRGAGYVEVLVIPAGARRIKV----VEEKPAHSYLALRDA-GKQS 838
Query: 774 FNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDV 833
N ++ + S N+ G T + Y E+I++ L L VL + N +
Sbjct: 839 INSDWKIEHS-GAFNLAG--TTVHYV-RRGLWEKISAKGPTTAPLHLLVLLFQD-QNYGL 893
Query: 834 HYSFNIPLEERSD---------MFTWDPYGPWEGCTKMCQGLQRR---NITCIHKSDHSV 881
HY + IP + + +F W + WE C C G +R+ + T I + S+
Sbjct: 894 HYEYTIPSDPLPENQSSKAPEPLFMW-THTSWEDCDATCGGGERKTTVSCTKIMSKNISI 952
Query: 882 VSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQ 940
V +++C +L P + CN C+ RW + + CS CG+G ++ + C + + G
Sbjct: 953 VDNEKCKYLTKPEPQIRKCNEQPCQTRWMMTEWTPCSRTCGKGMQSRQVACTQ-QLSNGT 1011
Query: 941 TVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHR 1000
++ + C KP + + C G T W WS+CS CG G R R C N
Sbjct: 1012 LIRARERDCIGP-KPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKC 1070
Query: 1001 LADNECQELSRVTRENCNEFS-CPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGF 1059
+ +E E+C ++S C W +WS+C +TCGKG + R + C +
Sbjct: 1071 VLSTRPRE-----AEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE 1125
Query: 1060 CNSSTKPESLSPCELHTC 1077
C SS KP + PC L C
Sbjct: 1126 CFSSEKPAAYRPCHLQPC 1143
Score = 128 bits (322), Expect = 5e-29
Identities = 75/250 (30%), Positives = 107/250 (42%), Gaps = 36/250 (14%)
Query: 1025 WAASEWSECLVTCGKGTKQRQVWC----QLNVDHLSDGFCNSSTKPE-SLSPCELHTCAS 1079
W + W +C TCG G ++ V C N+ + + C TKPE + C C +
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
Query: 1080 -WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVL---EDTECHEASRPSDRQSCVLTPCS 1135
W + W PC+ TCG G Q R V C +L++ L + +C +P+ Q C C
Sbjct: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCI-GPKPASAQRCEGQDC- 1036
Query: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHL 1195
M W G W+ CSV CG+G + R V C + + C
Sbjct: 1037 -----------------MTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKK------CVLS 1073
Query: 1196 PRPAEIWDC--FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPL 1253
RP E DC ++ C W+ GDWS CS +CG G +R + CM+ N C +P
Sbjct: 1074 TRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPA 1133
Query: 1254 MEQECSLAAC 1263
+ C L C
Sbjct: 1134 AYRPCHLQPC 1143
Score = 125 bits (315), Expect = 3e-28
Identities = 72/234 (30%), Positives = 109/234 (46%), Gaps = 20/234 (8%)
Query: 1308 WRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASY-----CDAASKP-PELQQCGPGPCP- 1360
W W C ++C GG + V C ++ S C +KP P++++C PC
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPCQT 978
Query: 1361 QWNYGNWGECSQTCGGGIKSRLVIC--QFPNGQILEDHNCEIVN-KPPSVIQCHMHACPA 1417
+W W CS+TCG G++SR V C Q NG ++ + + KP S +C C
Sbjct: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCMT 1038
Query: 1418 DVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSV-RCPS 1476
W W+ CS CGKG ++R V C + ++ C +P + C +C
Sbjct: 1039 --VWEAGVWSECSVKCGKGIRHRTVRCTNPRKK------CVLSTRPREAEDCEDYSKCYV 1090
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
W+ W++CS+TCG G+Q R + C K G+ E C S +P + R C Q C
Sbjct: 1091 WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNE-CFSSEKPAAYRPCHLQPC 1143
Score = 121 bits (303), Expect = 7e-27
Identities = 147/660 (22%), Positives = 250/660 (37%), Gaps = 81/660 (12%)
Query: 975 WSQCSRS-CGGGERSRESYCM-----NNFGHRLADNECQELSRVTRENCNEFSCPSWAAS 1028
WS+CS+ RS+ S C+ + + ++ ++ E C P +
Sbjct: 521 WSRCSKEDLERFLRSKASNCLLQTNPQSVNSVMVPSKLPGMTYTADEQCQILFGPLASFC 580
Query: 1029 EWSECLVTCGKGTK-QRQVWCQLNVDHLSDG-------FCNSSTKPESLSPCELHTCASW 1080
+ + ++ G K + + C+ +D DG +C + S E H W
Sbjct: 581 QEMQHVICTGLWCKVEGEKECRTKLDPPMDGTDCDLGKWCKAGECTSRTSAPE-HLAGEW 639
Query: 1081 QVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDR-QSCVLTPC----- 1134
+ W PC+ TC G R+ KC D+E + + P + + C PC
Sbjct: 640 SL--WSPCSRTCSAGISSRERKCPGL-------DSEARDCNGPRKQYRICENPPCPAGLP 690
Query: 1135 SFIS-KLETALLPTVLIKKMAQWRH--GSWTPCSVSCGRGTQARYVSCRDALDRIADESY 1191
F + + + T K + QW+ PC++ C + + + + ++ D +
Sbjct: 691 GFRDWQCQAYSVRTSSPKHILQWQAVLDEEKPCALFCSPVGKEQPILLSE---KVMDGTS 747
Query: 1192 CAHLPRP------AEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENY 1245
C + + C G D C G+GK+ + ++ +++ Y
Sbjct: 748 CGYQGLDICANGRCQKVGCDGLLGSLAREDH--CGVCNGNGKSCK-IIKGDFNHTRGAGY 804
Query: 1246 CDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRG 1305
+ V P + + PAHS+ ++++ + N VR
Sbjct: 805 VEVLVIPAGARRIKVVEEKPAHSYLALRDAGKQS-INSDWKIEHSGAFNLAGTTVHYVRR 863
Query: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDEN-GQSASYCDAASKPPELQQC-GPGPCPQWN 1363
W S + L ++ QD+N G Y + PE Q P P W
Sbjct: 864 GLWEKI---SAKGPTTAPLHLLVLLFQDQNYGLHYEYTIPSDPLPENQSSKAPEPLFMWT 920
Query: 1364 YGNWGECSQTCGGGIKSRLVIC---QFPNGQILEDHNCEIVNKP-PSVIQCHMHACPADV 1419
+ +W +C TCGGG + V C N I+++ C+ + KP P + +C+ C
Sbjct: 921 HTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPC--QT 978
Query: 1420 SWHQEPWTSCSASCGKGRKYREVFCIDQFQR----KLEDTNCSQVQKPPTHKACRSVRCP 1475
W WT CS +CGKG + R+V C Q + + +C KP + + C C
Sbjct: 979 RWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIG-PKPASAQRCEGQDCM 1037
Query: 1476 S-WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHK 1534
+ W+A W+ECSV CG G++ R V C + C STRP ++DC +
Sbjct: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCTNP------RKKCVLSTRPRE-----AEDCEDYS 1086
Query: 1535 GMERGRL----NCSTSCERKDSHQRMECTDNQI-RQVNEIVYNSSTISLTSKNCRNPPCN 1589
R+ CS +C + + ++C R NE SS + C PCN
Sbjct: 1087 KCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECF--SSEKPAAYRPCHLQPCN 1144
Score = 95.1 bits (235), Expect = 6e-19
Identities = 65/241 (26%), Positives = 99/241 (41%), Gaps = 24/241 (9%)
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRL---KGVGQVVEEMCDQSTRPCSQ-RRCWSQDCVQ 1532
W SW +C TCG G ++ V C K + V E C T+P Q R+C Q C Q
Sbjct: 919 WTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIVDNEKCKYLTKPEPQIRKCNEQPC-Q 977
Query: 1533 HKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTIS---LTSKNCRNPPCN 1589
+ M CS +C + +++ CT I +++ C C
Sbjct: 978 TRWMMTEWTPCSRTCGKGMQSRQVACTQQLSNGTLIRARERDCIGPKPASAQRCEGQDCM 1037
Query: 1590 YIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCI 1649
+ S+C+ CG R R CT + +K + RP ++C V
Sbjct: 1038 TVWEAGVWSECSVKCGKGIRHRTVRCT---NPRKKCVLSTRPREAEDCEDYSKCYV---- 1090
Query: 1650 NSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITK-HGLSSDLCLNHLKPGAQKKCYAND 1708
W++G WSKCS+TCG G+ R ++C+ K G + C + KP A + C+
Sbjct: 1091 --------WRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEKPAAYRPCHLQP 1142
Query: 1709 C 1709
C
Sbjct: 1143 C 1143
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 454 bits (1168), Expect = e-127
Identities = 310/979 (31%), Positives = 463/979 (47%), Gaps = 95/979 (9%)
Query: 80 YRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSD----LRHCFYRGQV 135
Y T +G+ L L +A +A G T W+ + G + L C Y G V
Sbjct: 111 YNVTVFGRDLHLRLRPNARLVAPGATM---------EWQGEKGTTRVEPLLGSCLYVGDV 161
Query: 136 NSQEDYKAV-VSLCGGLTGTFKGQNGEYFLEPIMKA-DGNEYEDGHNKPHLIYRQDLNNS 193
+ +V +S C GL G + + E+F+EP+ K E E G + H++YR+ +
Sbjct: 162 AGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQG--RVHVVYRRPPTSP 219
Query: 194 FLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKR 253
L Q +T + +++ L V++E N + RRH+
Sbjct: 220 PL--------GGPQALDTGASLDSLDSLSRALGVLEEHA------NSSRRRARRHAADDD 265
Query: 254 LISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVM 312
IE+++ D VV HG ++Q Y+LTLM+IV IY D S+G I++V+V++++
Sbjct: 266 Y-----NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIIL 320
Query: 313 IHREEEGPVINFDGAT-TLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNM 371
+ + +I + +L+N C W Q D H +HD A+ +TR+D S M
Sbjct: 321 LSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS----GM 376
Query: 372 LGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKEMKVTKYHVM 430
G + + +C P++SC +N E G SAF +AHE GH LG++HD RC + +V +M
Sbjct: 377 QGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGD-EVRLGSIM 435
Query: 431 APALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCE 490
AP + + WS CS++ ++ +L + +CLLD P + +LPG Y N+QC
Sbjct: 436 APLVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDDPFAHDWPALPQLPGLHYSMNEQCR 493
Query: 491 LAFGPGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVN 547
FG G MC C LWC+ + + C T+ PP DGT C PG HC G C+
Sbjct: 494 FDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTMCAPGKHCFKGHCIW 552
Query: 548 KETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNT 607
+ +G WG W P+ SCSRTCG G++ TR+C+ P P NGG C G F+ C+
Sbjct: 553 LTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSR 612
Query: 608 DSCPKGTQDFREKQCS--DFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNY 665
CP DFRE+QC D +H D + WLP + K+RC LYC+ T
Sbjct: 613 QDCPDSLADFREEQCRQWDLYFEHGD-----AQHHWLP-HEHRDAKERCHLYCESRETGE 666
Query: 666 FYLLKDMVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTIT 724
+K MV DGT C + +CV+G C GCD V+ SS + DKCGVCGGDNS CK +
Sbjct: 667 VVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVK 726
Query: 725 GVFNSS--HYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAE-GNFLFNGNFLLS 781
G F S +GY + +IPAGA ++ I++ + +LA+ + E G F+ N +
Sbjct: 727 GTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSH----HLAVKNLETGKFILNEENDVD 782
Query: 782 TSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGN----------LYNP 831
S K G EY + E + + + + V+ VG+ ++
Sbjct: 783 ASSKTFIAMGVEW--EYRDEDGR-ETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHED 839
Query: 832 DVHYSFNIPLEERSDMFTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHL 890
++ N LEE S ++ W W C+K C G Q C + DH +V C L
Sbjct: 840 SLNVDDNNVLEEDSVVYEW-ALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAAL 898
Query: 891 PLPSFVTQSCN-TDCELRWHVIGKSE-CSSQCGQ-GYRTLDIHCMKYSIHEGQTVQVDDH 947
P + ++CN +C V G+ E CS CG+ G + + C++ +H+ T V
Sbjct: 899 SKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQ-PLHDNTTRSVHAK 957
Query: 948 YCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNE-- 1005
+C D +P ++ C RW WSQCS +CG G + R C R AD+
Sbjct: 958 HCND-ARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC------RTADDSFG 1010
Query: 1006 -CQELSRVTRENCNEFSCP 1023
CQE T C CP
Sbjct: 1011 ICQEERPETARTCRLGPCP 1029
Score = 100 bits (250), Expect = 1e-20
Identities = 70/217 (32%), Positives = 93/217 (42%), Gaps = 36/217 (16%)
Query: 933 KYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESY 992
KY IHE ++ VDD+ + + V W +WS CS+ CGGG + +
Sbjct: 833 KYMIHE-DSLNVDDN-----------NVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYG 880
Query: 993 CMNNFGHRLADNE-CQELSR--VTRENCNEFSC--PSWAASEWSECLVTCGK-GTKQRQV 1046
C H++ C LS+ R CN C P W EW C TCG+ G + R V
Sbjct: 881 CRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSV 940
Query: 1047 WCQLNVDHLSDG--------FCNSSTKPESLSPCELHTC-ASWQVGPWGPCTTTCGHGYQ 1097
C + L D CN + +PES C C W+ GPW C+ TCG+G Q
Sbjct: 941 RC---IQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQ 996
Query: 1098 MRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
R V C S + C E RP ++C L PC
Sbjct: 997 ERPVLCRTADDSFGI----CQE-ERPETARTCRLGPC 1028
Score = 100 bits (250), Expect = 1e-20
Identities = 57/169 (33%), Positives = 83/169 (49%), Gaps = 28/169 (16%)
Query: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPESLS-PCELHTCAS-- 1079
WA +WS C CG G++ + C+ +DH + GFC + +KP+++ C C+
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
Query: 1080 WQVGPWGPCTTTCGH-GYQMRDVKCVNEL---ASAVLEDTECHEASRPSDRQSCVLTPCS 1135
W G W PC+ TCG G Q+R V+C+ L + + C++A RP R++C C
Sbjct: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
Query: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD 1184
+WR G W+ CSV+CG GTQ R V CR A D
Sbjct: 977 ------------------GRWRAGPWSQCSVTCGNGTQERPVLCRTADD 1007
Score = 95.9 bits (237), Expect = 3e-19
Identities = 63/221 (28%), Positives = 88/221 (39%), Gaps = 61/221 (27%)
Query: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRDALD-RIADESYCAHLPRPAEIWDCFTP--CGE- 1210
+W W+PCS CG G+Q CR LD ++ +CA L +P I P C +
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
Query: 1211 -WQAGDWSPCSASCGH-GKTTRQVLCMNYHQPIDEN--------YCDPEVRPLMEQECSL 1260
W G+W PCS +CG G R V C+ QP+ +N +C+ + RP + CS
Sbjct: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCI---QPLHDNTTRSVHAKHCN-DARPESRRACSR 972
Query: 1261 AACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC 1320
CP +WR GPW CS +C
Sbjct: 973 ELCP-----------------------------------------GRWRAGPWSQCSVTC 991
Query: 1321 SGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQ 1361
G Q R V+C+ + S C +P + C GPCP+
Sbjct: 992 GNGTQERPVLCRTAD-DSFGICQ-EERPETARTCRLGPCPR 1030
Score = 95.5 bits (236), Expect = 4e-19
Identities = 64/200 (32%), Positives = 86/200 (43%), Gaps = 26/200 (13%)
Query: 1291 LEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ---DENGQSASYCDAASK 1347
L ++N V+ +W W CS C GG Q C+ D +C A SK
Sbjct: 841 LNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSK 900
Query: 1348 PPELQQ-CGPGPC--PQWNYGNWGECSQTCG-GGIKSRLVICQFPNGQILEDHNCEIVN- 1402
P +++ C P C P W G W CSQTCG G++ R V C P L D+ V+
Sbjct: 901 PKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQP----LHDNTTRSVHA 956
Query: 1403 ------KPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT- 1455
+P S C CP W PW+ CS +CG G + R V C R +D+
Sbjct: 957 KHCNDARPESRRACSRELCPG--RWRAGPWSQCSVTCGNGTQERPVLC-----RTADDSF 1009
Query: 1456 NCSQVQKPPTHKACRSVRCP 1475
Q ++P T + CR CP
Sbjct: 1010 GICQEERPETARTCRLGPCP 1029
Score = 89.4 bits (220), Expect = 3e-17
Identities = 53/174 (30%), Positives = 85/174 (48%), Gaps = 11/174 (6%)
Query: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFP-NGQILEDHNCEIVNKPPSVIQ-CHMHACPAD 1418
+W W CS+ CGGG + C+ + +++ C ++KP ++ + C+ C
Sbjct: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
Query: 1419 VSWHQEPWTSCSASCGK-GRKYREVFCI----DQFQRKLEDTNCSQVQKPPTHKACRSVR 1473
V W W CS +CG+ G + R V CI D R + +C+ +P + +AC
Sbjct: 917 V-WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSREL 974
Query: 1474 CPS-WKANSWNECSVTCGSGVQQRDVYCRLKGVG-QVVEEMCDQSTRPCSQRRC 1525
CP W+A W++CSVTCG+G Q+R V CR + +E ++ R C C
Sbjct: 975 CPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPC 1028
Score = 85.5 bits (210), Expect = 5e-16
Identities = 61/194 (31%), Positives = 78/194 (40%), Gaps = 31/194 (15%)
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFIS 1138
W + W PC+ CG G Q C L ++ C S+P R++C CS
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS--- 914
Query: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSCRDAL-DRIADESYCAHL- 1195
W G W PCS +CGR G Q R V C L D + H
Sbjct: 915 --------------QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN 960
Query: 1196 -PRPAEIWDCFTPC--GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENY--CDPEV 1250
RP C G W+AG WS CS +CG+G R VLC + D+++ C E
Sbjct: 961 DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC----RTADDSFGICQEE- 1015
Query: 1251 RPLMEQECSLAACP 1264
RP + C L CP
Sbjct: 1016 RPETARTCRLGPCP 1029
Score = 49.7 bits (117), Expect = 3e-05
Identities = 55/237 (23%), Positives = 83/237 (35%), Gaps = 70/237 (29%)
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEE-MCDQSTRPCSQRR-CWSQDCVQHK 1534
W W+ CS CG G Q CR + ++V C ++P + RR C Q+C Q
Sbjct: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
Query: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEI--VYNSSTISLTSKNCRNPPCNYIV 1592
+ CS +C R T Q+R V I +++++T S+ +K
Sbjct: 918 WVTGEWEPCSQTCGR---------TGMQVRSVRCIQPLHDNTTRSVHAK----------- 957
Query: 1593 VTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSC 1652
+C + + R + CP
Sbjct: 958 ---------------------HCNDARPESRRACSR------ELCP-------------- 976
Query: 1653 LHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
W+ G WS+CSVTCG G +R V C T S +C +P + C C
Sbjct: 977 ---GRWRAGPWSQCSVTCGNGTQERPVLCRTADD-SFGICQEE-RPETARTCRLGPC 1028
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 453 bits (1166), Expect = e-127
Identities = 321/1040 (30%), Positives = 462/1040 (44%), Gaps = 144/1040 (13%)
Query: 84 AYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSDLRHCFYRGQVNSQEDYKA 143
A+G+ L L D FL+ G+ E GA P++L CFY G+V
Sbjct: 87 AFGRDLYLQLRRDLRFLSRGFE-----VEEAGAARRRGRPAEL--CFYSGRVLGHPGSLV 139
Query: 144 VVSLCG---GLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQDLNNSFLQTLKY 200
+S CG GL G + + ++P+ + G + HLI R+
Sbjct: 140 SLSACGAAGGLVGLIQLGQEQVLIQPLNNSQG----PFSGREHLIRRK------------ 183
Query: 201 CSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISYPRY 260
S++ S E P + + L K+ G P +D R RL S
Sbjct: 184 WSLTPSPSAEAQRP----EQLCKVLTEKKKPTWGR-----PSRDWRERRNAIRLTS-EHT 233
Query: 261 IEIMVTADAKVVSAHGSNL-QNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEG 319
+E +V ADA +V HG+ Q +ILT+M++V +++ S+G I+I V KLV++ +
Sbjct: 234 VETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQVTKLVLLRQRPAK 293
Query: 320 PVINFDGATTLKNFCSWQ-------------QTQNDLDDVHPSHHDTAVLITREDICSSK 366
I G +L++FC WQ Q DD P D AV +TR D C K
Sbjct: 294 LSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDD--PPLVDAAVFVTRTDFCVHK 351
Query: 367 -EKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVT 425
E C+ +G++YLG +C + C + E+ GL AFTIAHELGH LG+ HDD+
Sbjct: 352 DEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNHDDD---HSSCAG 408
Query: 426 KYHVMAPALSFHMSP--WSWSNCSRKYVTEFLDTGYGECLL--DKPDEEIYNLPSELPGS 481
+ H+M+ +P SWS+CSR + FL + CLL D + LP +LPG
Sbjct: 409 RSHIMSGEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQHTVRLPHKLPGM 468
Query: 482 RYDGNKQCELAFGPGSQMCPHIN--ICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMH 539
Y N+QC++ FG + C ++ +C LWC C T+ PP DGT+CG
Sbjct: 469 HYSANEQCQILFGMNATFCRNMEHLMCAGLWCLVEGDT--SCKTKLDPPLDGTECGADKW 526
Query: 540 CRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRR 599
CR G CV+K V+G+W PW +S CSRTCG G R+C+ P P GG +C G
Sbjct: 527 CRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGAS 586
Query: 600 MKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGT-----KDRC 654
++ C CPKG FR++QC ++ R P+ G+ T C
Sbjct: 587 VEHAVCENLPCPKGLPSFRDQQCQ-------------AHDRLSPKKKGLLTAVVVDDKPC 633
Query: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
+LYC G L+ D V DGTPCG D+CV G+C GCD ++ S+AK D+CGVC
Sbjct: 634 ELYCSPLGKESPLLVADRVLDGTPCGPYETDLCVHGKCQKIGCDGIIGSAAKEDRCGVCS 693
Query: 715 GDNSSCKTITGVFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLF 774
GD +C + G F SH + G+ N D + + G F
Sbjct: 694 GDGKTCHLVKGDF--SHARGTALKDSGKGSINSDWK---------------IELPGEFQI 736
Query: 775 NGNFLLSTSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVH 834
G T + Y E+I++ + L L VL + + +H
Sbjct: 737 AG-----------------TTVRYV-RRGLWEKISAKGPTKLPLHLMVLLFHD-QDYGIH 777
Query: 835 YSFNIPLEERSD-----------MFTWDPYGPWEGCTKMCQGLQRRNI---TCIHKSDHS 880
Y + +P+ ++ +F W G WEGC+ C G +RR I T I +
Sbjct: 778 YEYTVPVNRTAENQSEPEKPQDSLFIWTHSG-WEGCSVQCGGGERRTIVSCTRIVNKTTT 836
Query: 881 VVSDKECDHLPLPSFVTQSCNT-DCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEG 939
+V+D +C P + CN C+ RW S CS+ C +G++ ++ C+ Y + G
Sbjct: 837 LVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCV-YQLQNG 895
Query: 940 QTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGH 999
V YC +P + C G + W SEWSQCS SCG G R C N+ G
Sbjct: 896 THVATRPLYCPGP-RPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVACTNSQG- 953
Query: 1000 RLADNECQELSRV-TRENCNEFS-CPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSD 1057
+C +R E C ++S C W +WS C TCGKG + R V C V
Sbjct: 954 -----KCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHG 1008
Query: 1058 GFCNSSTKPESLSPCELHTC 1077
C + +KP C C
Sbjct: 1009 SECPALSKPAPYRQCYQEVC 1028
Score = 130 bits (328), Expect = 9e-30
Identities = 83/265 (31%), Positives = 118/265 (44%), Gaps = 37/265 (13%)
Query: 1013 TRENCNEFSCPS-----WAASEWSECLVTCGKGTKQRQVWCQLNVDH----LSDGFCNSS 1063
T EN +E P W S W C V CG G ++ V C V+ ++D C +
Sbjct: 787 TAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQA 846
Query: 1064 TKPE-SLSPCELHTCAS-WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTE---CH 1118
++PE + C LH C S W GPW PC+ TC G+Q R+V CV +L + T C
Sbjct: 847 SRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYC- 905
Query: 1119 EASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVS 1178
RP+ QSC C I W W+ CS SCG+G R V+
Sbjct: 906 PGPRPAAVQSCEGQDCLSI------------------WEASEWSQCSASCGKGVWKRTVA 947
Query: 1179 CRDALDRIADESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYH 1238
C ++ + + PR E + ++ C EW+ GDWS CS++CG G +R V CM+
Sbjct: 948 CTNSQGKCDASTR----PRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKV 1003
Query: 1239 QPIDENYCDPEVRPLMEQECSLAAC 1263
+ C +P ++C C
Sbjct: 1004 TGRHGSECPALSKPAPYRQCYQEVC 1028
Score = 128 bits (321), Expect = 6e-29
Identities = 144/603 (23%), Positives = 217/603 (35%), Gaps = 110/603 (18%)
Query: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAAS-EW 1030
+ WS CSR+CG G R R+ C +N C S V C CP S
Sbjct: 549 WGAWSMCSRTCGTGARFRQRKC-DNPPPGPGGTHCPGAS-VEHAVCENLPCPKGLPSFRD 606
Query: 1031 SECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCTT 1090
+C K++ + + VD PCEL+ C+ +G P
Sbjct: 607 QQCQAHDRLSPKKKGLLTAVVVDD---------------KPCELY-CSP--LGKESPLL- 647
Query: 1091 TCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLI 1150
+A VL+ T C P + CV C I ++ +
Sbjct: 648 ----------------VADRVLDGTPCG----PYETDLCVHGKCQKIGC--DGIIGSAAK 685
Query: 1151 KKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTPCGE 1210
+ G C + G + AR + +D+ + + LP +I T
Sbjct: 686 EDRCGVCSGDGKTCHLVKGDFSHARGTALKDSGKGSINSDWKIELPGEFQI--AGTTVRY 743
Query: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHF 1270
+ G W SA G K ++ + +H D++Y
Sbjct: 744 VRRGLWEKISAK-GPTKLPLHLMVLLFH---DQDY------------------------- 774
Query: 1271 PSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVV 1330
+ +P+ + E N+++ P W W CS C GG + V
Sbjct: 775 -------GIHYEYTVPVNRTAE-NQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVS 826
Query: 1331 CQDENGQSA-----SYCDAASKP-PELQQCGPGPCP-QWNYGNWGECSQTCGGGIKSRLV 1383
C ++ S C AS+P P++++C PC +W G W CS TC G + R V
Sbjct: 827 CTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPCQSRWVAGPWSPCSATCEKGFQHREV 886
Query: 1384 IC--QFPNGQILEDHNCEIVNKPPSVIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYR 1440
C Q NG + P+ +Q C C + W W+ CSASCGKG R
Sbjct: 887 TCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCLS--IWEASEWSQCSASCGKGVWKR 944
Query: 1441 EVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVR-CPSWKANSWNECSVTCGSGVQQRDVY 1499
V C + C +P +AC C WK W+ CS TCG G+Q R V
Sbjct: 945 TVACTNS------QGKCDASTRPRAEEACEDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQ 998
Query: 1500 CRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECT 1559
C K G+ E C ++P R+C+ + C R+N +T + + +CT
Sbjct: 999 CMHKVTGRHGSE-CPALSKPAPYRQCYQEVC-------NDRINANTITSPRLAALTYKCT 1050
Query: 1560 DNQ 1562
+Q
Sbjct: 1051 RDQ 1053
Score = 87.4 bits (215), Expect = 1e-16
Identities = 67/241 (27%), Positives = 95/241 (39%), Gaps = 24/241 (9%)
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRL---KGVGQVVEEMCDQSTRPCSQ-RRCWSQDCVQ 1532
W + W CSV CG G ++ V C K V + C Q++RP Q RRC C Q
Sbjct: 804 WTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVNDSDCPQASRPEPQVRRCNLHPC-Q 862
Query: 1533 HKGMERGRLNCSTSCERKDSHQRMECT---DNQIRQVNEIVYNSSTISLTSKNCRNPPCN 1589
+ + CS +CE+ H+ + C N +Y ++C C
Sbjct: 863 SRWVAGPWSPCSATCEKGFQHREVTCVYQLQNGTHVATRPLYCPGPRPAAVQSCEGQDCL 922
Query: 1590 YIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCI 1649
I ++ SQC+ +CG +R CT RP + C +
Sbjct: 923 SIWEASEWSQCSASCGKGVWKRTVACTNSQGKCDAST---RPRAEEAC---------EDY 970
Query: 1650 NSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITK-HGLSSDLCLNHLKPGAQKKCYAND 1708
+ C WK G WS CS TCG G+ R V+C+ K G C KP ++CY
Sbjct: 971 SGCYE---WKTGDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEV 1027
Query: 1709 C 1709
C
Sbjct: 1028 C 1028
Score = 35.0 bits (79), Expect = 0.70
Identities = 26/71 (36%), Positives = 31/71 (43%), Gaps = 17/71 (23%)
Query: 1178 SCRDALDRIADESYCAHLPRPAEIW----DCF--TPCGEWQAGDWSP------CSASCGH 1225
SC+ LD D + C A+ W +C TP E GDWSP CS +CG
Sbjct: 507 SCKTKLDPPLDGTECG-----ADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGT 561
Query: 1226 GKTTRQVLCMN 1236
G RQ C N
Sbjct: 562 GARFRQRKCDN 572
Score = 31.6 bits (70), Expect = 7.8
Identities = 13/21 (61%), Positives = 13/21 (61%)
Query: 1661 GKWSKCSVTCGIGIMKRQVKC 1681
G WS CS TCG G RQ KC
Sbjct: 550 GAWSMCSRTCGTGARFRQRKC 570
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
3 proprotein [Homo sapiens]
Length = 1205
Score = 445 bits (1145), Expect = e-124
Identities = 302/1004 (30%), Positives = 470/1004 (46%), Gaps = 90/1004 (8%)
Query: 34 VRTLTSYEVVIPERVNEFGEVFPQSHHFSRQKRSSEALEPMPFRTHYRFTAYGQLFQLNL 93
++ YE+V P N G + S +KRS+ + P + + TA+G+ F L L
Sbjct: 36 IKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNPEQLFFNITAFGKDFHLRL 95
Query: 94 TADASFLAAGY------TEVHLGTPERGAWESDAGPSDLR---------HCFYRGQVNSQ 138
+ +A G T + G G + R +C Y G +
Sbjct: 96 KPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKTEPLQTNCAYVGDIVDI 155
Query: 139 EDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIYRQD-LNNSFLQT 197
+S C GL G K N EYF+EP+ + G + E+ + H++Y++ + + +
Sbjct: 156 PGTSVAISNCDGLAGMIKSDNEEYFIEPLER--GKQMEEEKGRIHVVYKRSAVEQAPIDM 213
Query: 198 LKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKRLISY 257
K ES ++ Y N+++ LN R RRH+ +
Sbjct: 214 SKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRR--------------RRHAGENDY--- 256
Query: 258 PRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHRE 316
IE+++ D VV HG ++QNY+LTLM+IV IY D S+G I++V+V+++M+
Sbjct: 257 --NIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYA 314
Query: 317 EEGPVINFDGAT-TLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGLS 375
+ +I + +L+N C W Q D H HHD A+ +TR+D + M G +
Sbjct: 315 KSISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPA----GMQGYA 370
Query: 376 YLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKEMKVTKYHVMAPAL 434
+ +C P++SC +N E G SAF +AHE GH LG++HD RC + + VMAP +
Sbjct: 371 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGD-ETAMGSVMAPLV 429
Query: 435 SFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFG 494
+ WS CS + + ++ + +CLLD P + + ELPG Y ++QC FG
Sbjct: 430 QAAFHRYHWSRCSGQELKRYIHSY--DCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFG 487
Query: 495 PGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETE 551
G +MC C LWC+ + + C T+ PP DGT+C G C G C+ K
Sbjct: 488 VGYKMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAAGKWCYKGHCMWKNAN 546
Query: 552 TRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCP 611
+ +G WG W + SCSRTCG G+ TR+CN P P NGG C G +++ CNT+ C
Sbjct: 547 QQKQDGNWGSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQ 606
Query: 612 KGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKD 671
K +DFR +QC N H + + WLP Y K RC LYCQ T +K
Sbjct: 607 KHFEDFRAQQCQQRN-SHFEYQN--TKHHWLP-YEHPDPKKRCHLYCQSKETGDVAYMKQ 662
Query: 672 MVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSS 730
+V DGT C + + ICV+G+C+ GCD + S+ DKCGVCGGDNS C+T+ G F +
Sbjct: 663 LVHDGTHCSYKDPYSICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRT 722
Query: 731 --HYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLAL-SDAEGNFLFNGNFLLSTSKKEI 787
GY + IP GA +V I++ + LA+ + A G+++ NG + S+ I
Sbjct: 723 PRKLGYLKMFDIPPGARHVLIQE----DEASPHILAIKNQATGHYILNGKGEEAKSRTFI 778
Query: 788 NVQGTRTVIEYS-GSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSF--------- 837
++ +E+ + +E +++ +I+ ++ N + Y +
Sbjct: 779 DLG-----VEWDYNIEDDIESLHTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPT 833
Query: 838 ---NIPLEERSDMFTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLP 893
N ++E D F W W C+K C G Q C KSD+ +V C+ P
Sbjct: 834 INSNNVIQEELDTFEW-ALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKP 892
Query: 894 SFVTQSCN-TDC-ELRWHVIGKSECSSQCG-QGYRTLDIHCMKYSIHEGQTVQVDDHYC- 949
+ + CN +C W C+ CG GY+ + C++ + +G V YC
Sbjct: 893 KPIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQ-PLLDGTNRSVHSKYCM 951
Query: 950 GDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYC 993
GD +P ++ C+ +W WS+CS +CG G R+ C
Sbjct: 952 GD--RPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLC 993
Score = 95.1 bits (235), Expect = 6e-19
Identities = 58/180 (32%), Positives = 78/180 (43%), Gaps = 26/180 (14%)
Query: 970 WHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADN---ECQELSRVTRENCNEFSC--PS 1024
W WSQCS+ CGGG + + C +++ E + + R CN C P
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 1025 WAASEWSECLVTCG-KGTKQRQVWCQLNVDHLSDGFCNS-------STKPESLSPCELHT 1076
W A EW C TCG G + R V C + L DG S +PES PC
Sbjct: 909 WVAEEWEHCTKTCGSSGYQLRTVRC---LQPLLDGTNRSVHSKYCMGDRPESRRPCNRVP 965
Query: 1077 C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCS 1135
C A W+ GPW C+ TCG G ++R V C C + +P ++C L PC+
Sbjct: 966 CPAQWKTGPWSECSVTCGEGTEVRQVLC--------RAGDHC-DGEKPESVRACQLPPCN 1016
Score = 94.7 bits (234), Expect = 7e-19
Identities = 71/241 (29%), Positives = 103/241 (42%), Gaps = 32/241 (13%)
Query: 1294 NENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ---DENGQSASYCDAASKP-P 1349
N N V+ + +W W CS C GG Q+ C+ D S+C+A KP P
Sbjct: 835 NSNNVIQEELDTFEWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKP 894
Query: 1350 ELQQCGPGPC--PQWNYGNWGECSQTCG-GGIKSRLVICQFPNGQILEDHNCEIVNK--- 1403
+ C C P W W C++TCG G + R V C P +L+ N + +K
Sbjct: 895 IRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQP---LLDGTNRSVHSKYCM 951
Query: 1404 ---PPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQV 1460
P S C+ CPA W PW+ CS +CG+G + R+V C +C
Sbjct: 952 GDRPESRRPCNRVPCPA--QWKTGPWSECSVTCGEGTEVRQVLC-------RAGDHCDG- 1001
Query: 1461 QKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQ--STR 1518
+KP + +AC+ C + S+ C V R YC + G ++ E C + ST
Sbjct: 1002 EKPESVRACQLPPCND--EPCLGDKSIFCQMEVLAR--YCSIPGYNKLCCESCSKRSSTL 1057
Query: 1519 P 1519
P
Sbjct: 1058 P 1058
Score = 94.0 bits (232), Expect = 1e-18
Identities = 55/179 (30%), Positives = 77/179 (43%), Gaps = 29/179 (16%)
Query: 1010 SRVTRENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPE 1067
+ V +E + F WA WS+C CG G + + C+ D+ + FC ++ KP+
Sbjct: 837 NNVIQEELDTFE---WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPK 893
Query: 1068 SLSP-CELHTCAS--WQVGPWGPCTTTCGH-GYQMRDVKCVNELASAVLEDTECHEA--S 1121
+ C + C W W CT TCG GYQ+R V+C+ L
Sbjct: 894 PIRRMCNIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGD 953
Query: 1122 RPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCR 1180
RP R+ C PC AQW+ G W+ CSV+CG GT+ R V CR
Sbjct: 954 RPESRRPCNRVPCP------------------AQWKTGPWSECSVTCGEGTEVRQVLCR 994
Score = 94.0 bits (232), Expect = 1e-18
Identities = 58/186 (31%), Positives = 86/186 (46%), Gaps = 17/186 (9%)
Query: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQ--CHMHACPAD 1418
+W +W +CS+ CGGG + C+ + + + NK P I+ C++ C
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 1419 VSWHQEPWTSCSASCGK-GRKYREVFCIDQFQRKLEDTNCSQVQK------PPTHKACRS 1471
+ W E W C+ +CG G + R V C+ Q L+ TN S K P + + C
Sbjct: 908 L-WVAEEWEHCTKTCGSSGYQLRTVRCL---QPLLDGTNRSVHSKYCMGDRPESRRPCNR 963
Query: 1472 VRCPS-WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC 1530
V CP+ WK W+ECSVTCG G + R V CR G + +S R C C + C
Sbjct: 964 VPCPAQWKTGPWSECSVTCGEGTEVRQVLCR---AGDHCDGEKPESVRACQLPPCNDEPC 1020
Query: 1531 VQHKGM 1536
+ K +
Sbjct: 1021 LGDKSI 1026
Score = 74.7 bits (182), Expect = 8e-13
Identities = 55/218 (25%), Positives = 81/218 (37%), Gaps = 63/218 (28%)
Query: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRDALD-RIADESYCAHLPRP------AEIWDCFTP 1207
+W SW+ CS CG G Q CR D ++ S+C +P I +C P
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHP 907
Query: 1208 CGEWQAGDWSPCSASCGH-GKTTRQVLCMN-----YHQPIDENYCDPEVRPLMEQECSLA 1261
W A +W C+ +CG G R V C+ ++ + YC + RP + C+
Sbjct: 908 L--WVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGD-RPESRRPCNRV 964
Query: 1262 ACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCS 1321
CP QW+TGPW CS +C
Sbjct: 965 PCPA-----------------------------------------QWKTGPWSECSVTCG 983
Query: 1322 GGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPC 1359
G + R V+C ++ +CD KP ++ C PC
Sbjct: 984 EGTEVRQVLC-----RAGDHCD-GEKPESVRACQLPPC 1015
Score = 74.3 bits (181), Expect = 1e-12
Identities = 53/192 (27%), Positives = 75/192 (39%), Gaps = 33/192 (17%)
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFIS 1138
W + W C+ CG G+Q C + + ++ + C +P R+ C + C+
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTH-- 906
Query: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSCR----DALDRIADESYCA 1193
W W C+ +CG G Q R V C D +R YC
Sbjct: 907 ---------------PLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCM 951
Query: 1194 HLPRPAEIWDCF-TPC-GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
RP C PC +W+ G WS CS +CG G RQVLC ++CD E +
Sbjct: 952 G-DRPESRRPCNRVPCPAQWKTGPWSECSVTCGEGTEVRQVLCR------AGDHCDGE-K 1003
Query: 1252 PLMEQECSLAAC 1263
P + C L C
Sbjct: 1004 PESVRACQLPPC 1015
Score = 59.7 bits (143), Expect = 3e-08
Identities = 58/235 (24%), Positives = 80/235 (34%), Gaps = 70/235 (29%)
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEE-MCDQSTRPCSQRR-CWSQDCVQHK 1534
W SW++CS CG G Q CR K ++V C+ + +P RR C Q+C
Sbjct: 849 WALKSWSQCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPL 908
Query: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT 1594
+ +C+ +C SS L + C P + +
Sbjct: 909 WVAEEWEHCTKTC------------------------GSSGYQLRTVRCLQPLLDGTNRS 944
Query: 1595 ADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLH 1654
S C + S R C +P CP
Sbjct: 945 VHSKYCMGDRPESRRP----CNRVP-----------------CP---------------- 967
Query: 1655 LATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
A WK G WS+CSVTCG G RQV C + D C + KP + + C C
Sbjct: 968 -AQWKTGPWSECSVTCGEGTEVRQVLC-----RAGDHC-DGEKPESVRACQLPPC 1015
Score = 40.4 bits (93), Expect = 0.017
Identities = 64/254 (25%), Positives = 100/254 (39%), Gaps = 58/254 (22%)
Query: 378 GTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKVTKYHVMAPAL-SF 436
G + DP+ I +E S+ T + + H+D+ + +V+ L +F
Sbjct: 799 GPLHDPVIVLIIPQENDTRSSLTYKY-------IIHEDSVPT----INSNNVIQEELDTF 847
Query: 437 HMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPG 496
+ SWS CS+ F T YG C ++ ++ S + NK+ + P
Sbjct: 848 EWALKSWSQCSKPCGGGFQYTKYG-CRRKSDNKMVHR-------SFCEANKKPK----PI 895
Query: 497 SQMCPHINICMH-LWCTST-EKLHKGCFTQHV---------PPADGTDCGPGMHCRHGLC 545
+MC +I C H LW E K C + P DGT+ +H ++ C
Sbjct: 896 RRMC-NIQECTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTN--RSVHSKY--C 950
Query: 546 VNKETETR------PVNGEW--GPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVG 597
+ E+R P +W GPW S CS TCG G E C G++C G
Sbjct: 951 MGDRPESRRPCNRVPCPAQWKTGPW---SECSVTCGEGTEVRQVLC------RAGDHCDG 1001
Query: 598 RRMK-FRSCNTDSC 610
+ + R+C C
Sbjct: 1002 EKPESVRACQLPPC 1015
Score = 31.6 bits (70), Expect = 7.8
Identities = 13/29 (44%), Positives = 18/29 (62%), Gaps = 3/29 (10%)
Query: 1363 NYGNW---GECSQTCGGGIKSRLVICQFP 1388
N+G+W G CS+TCG G++ R C P
Sbjct: 553 NWGSWTKFGSCSRTCGTGVRFRTRQCNNP 581
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 419 bits (1076), Expect = e-116
Identities = 279/900 (31%), Positives = 422/900 (46%), Gaps = 69/900 (7%)
Query: 127 RHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIY 186
+ C Y G V +S C GL G + + ++F+EP+ + G + ++ + H++Y
Sbjct: 150 QECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLER--GQQEKEASGRTHVVY 207
Query: 187 RQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDER 246
R++ + + E H + DL +LG L D
Sbjct: 208 RRE-------------AVQQEWAEPDGDLHNEAFGLGDL----PNLLGLVGDQ--LGDTE 248
Query: 247 RHSRKKRLISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHI 305
R R + SY IE+++ D VV HG ++QNY+LTLM+IV IY D S+G I+I
Sbjct: 249 RKRRHAKPGSYS--IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINI 306
Query: 306 VVVKLVMI-HREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICS 364
+V+L+M+ +R+ + + + +L+ C W +Q D H HHD V +TR+D
Sbjct: 307 ALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGP 366
Query: 365 SKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKV 424
S M G + + +C PL+SC +N E G SAF IAHE GH LG++HD +
Sbjct: 367 S----GMQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADET 422
Query: 425 TKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYD 484
+ VMAP + + WS CS+ ++ +L + +CLLD P + + P ELPG Y
Sbjct: 423 SLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYS 480
Query: 485 GNKQCELAFGPGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCR 541
++QC FG G Q C C LWC+ + + C T+ PP DGT+C PG C
Sbjct: 481 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWCF 539
Query: 542 HGLCVNKETE-TRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRM 600
G C+ K E T +G W W + SCSR+CGGG+ S +R CN P P GG C+G
Sbjct: 540 KGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMF 599
Query: 601 KFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQV 660
+++ CN++ CP +DFR +QC+ N ++ + S W+P Y +C+L CQ
Sbjct: 600 EYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHS---WVP-YEPDDDAQKCELICQS 655
Query: 661 AGTNYFYLLKDMVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSS 719
A T + +V DGT C + + +C +G+C+ GCD + S DKCGVCGGDNS
Sbjct: 656 ADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSH 715
Query: 720 CKTITGVFN--SSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGN 777
C+T+ G S G +V+IPAGA ++ I S + + G+F+ N
Sbjct: 716 CRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKS---PHRIVVKNQVTGSFILNPK 772
Query: 778 FLLSTSKK--------EINVQGTRTVIEYSG---SNNAVERINSTNRQEKELILQVLCVG 826
+TS+ E V+ + ++ SG A+ + T + + +
Sbjct: 773 GKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 832
Query: 827 NLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDK 885
P + S N+ LEE D + W W C+K C G+Q C + DH +V
Sbjct: 833 EDLLPLIG-SNNVLLEE-MDTYEW-ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRH 889
Query: 886 ECDHLPLPSFVTQSCNTD--CELRWHVIGKSECSSQCGQ-GYRTLDIHCMKYSIHEGQTV 942
CDH P + + CN + W CS CG+ G +T I C+ + V
Sbjct: 890 LCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKV 949
Query: 943 QVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYC---MNNFGH 999
GD +P + C +W WSQCS +CG G + R+ C N+ GH
Sbjct: 950 MPAKACAGD--RPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH 1007
Score = 95.5 bits (236), Expect = 4e-19
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 8/148 (5%)
Query: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFPNGQ-ILEDHNCEIVNKP-PSVIQCHMHACPAD 1418
+W +W CS+ CGGGI+ C+ +++ H C+ +P P +C+ H C
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 912
Query: 1419 VSWHQEPWTSCSASCGK-GRKYREVFCI---DQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
V W E W +CS SCGK G + R + C+ K+ +P + C V C
Sbjct: 913 V-WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 971
Query: 1475 PS-WKANSWNECSVTCGSGVQQRDVYCR 1501
P+ W+ +W++CS TCG G+QQR V CR
Sbjct: 972 PAQWRLGAWSQCSATCGEGIQQRQVVCR 999
Score = 92.0 bits (227), Expect = 5e-18
Identities = 60/219 (27%), Positives = 89/219 (40%), Gaps = 45/219 (20%)
Query: 1019 EFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPESLSP-CELH 1075
E WA W+ C CG G + + C+ DH + C+ +P+ + C H
Sbjct: 848 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
Query: 1076 TCAS--WQVGPWGPCTTTCGH-GYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSC 1129
C+ W WG C+ +CG G Q R ++C+ L++ V+ C RP R+ C
Sbjct: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPC 966
Query: 1130 VLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIA-- 1187
+ PC AQWR G+W+ CS +CG G Q R V CR + +
Sbjct: 967 LRVPCP------------------AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC 1008
Query: 1188 -----DESYCAHLPR----------PAEIWDCFTPCGEW 1211
D LP A++W+ TP G+W
Sbjct: 1009 EGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQW 1047
Score = 91.3 bits (225), Expect = 8e-18
Identities = 55/176 (31%), Positives = 74/176 (42%), Gaps = 16/176 (9%)
Query: 970 WHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNE-CQELSR--VTRENCNEFSC--PS 1024
W W+ CS++CGGG + + C H + C R R CN+ C P
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 913
Query: 1025 WAASEWSECLVTCGK-GTKQRQVWCQLNVDH----LSDGFCNSSTKPESLSPCELHTC-A 1078
W EW C +CGK G + R + C L + + + + +PE+ PC C A
Sbjct: 914 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 973
Query: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
W++G W C+ TCG G Q R V C S C E RP Q C L C
Sbjct: 974 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSL----GHC-EGDRPDTVQVCSLPAC 1024
Score = 85.9 bits (211), Expect = 3e-16
Identities = 65/240 (27%), Positives = 103/240 (42%), Gaps = 25/240 (10%)
Query: 1254 MEQECSLAACPPAHSHFPSSPVQPSYYLSTNL-PLTQKLEDNENQVVHPSVRGNQWRTGP 1312
+ + ++ A PP P S + Y + +L PL N V+ + +W
Sbjct: 805 LPEAIAILALPPTEGG-PRSSLAYKYVIHEDLLPLI-----GSNNVLLEEMDTYEWALKS 858
Query: 1313 WGSCSSSCSGGLQHRAVVC---QDENGQSASYCDAASKP-PELQQCGPGPC--PQWNYGN 1366
W CS +C GG+Q C +D + CD +P P ++C PC P W
Sbjct: 859 WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEE 918
Query: 1367 WGECSQTCGG-GIKSRLVICQFP--NG--QILEDHNCEIVNKPPSVIQCHMHACPADVSW 1421
WG CS++CG G+++R + C P NG +++ C ++P + C CPA W
Sbjct: 919 WGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCPA--QW 975
Query: 1422 HQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANS 1481
W+ CSA+CG+G + R+V C + + +P T + C C NS
Sbjct: 976 RLGAWSQCSATCGEGIQQRQVVC----RTNANSLGHCEGDRPDTVQVCSLPACGGNHQNS 1031
Score = 83.6 bits (205), Expect = 2e-15
Identities = 59/198 (29%), Positives = 79/198 (39%), Gaps = 29/198 (14%)
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFIS 1138
W + W PC+ CG G Q C +++ C RP R+ C PCS
Sbjct: 854 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS--- 910
Query: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSC----RDALDRIADESYCA 1193
W W CS SCG+ G Q R + C + ++ CA
Sbjct: 911 --------------QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA 956
Query: 1194 HLPRPAEIWDCF-TPC-GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
RP C PC +W+ G WS CSA+CG G RQV+C + +C+ + R
Sbjct: 957 G-DRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL--GHCEGD-R 1012
Query: 1252 PLMEQECSLAACPPAHSH 1269
P Q CSL AC H +
Sbjct: 1013 PDTVQVCSLPACGGNHQN 1030
Score = 80.5 bits (197), Expect = 1e-14
Identities = 63/217 (29%), Positives = 87/217 (40%), Gaps = 56/217 (25%)
Query: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNY--HQPIDENYCDPEVRPL-MEQECSLAACPPA 1266
EW W+PCS +CG G + C H + + CD + RP + + C+ C
Sbjct: 853 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC--- 909
Query: 1267 HSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG-GLQ 1325
S PV W T WG+CS SC G+Q
Sbjct: 910 -----SQPV--------------------------------WVTEEWGACSRSCGKLGVQ 932
Query: 1326 HRAVVC--QDENG----QSASYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGGGI 1378
R + C NG A C A +P + C PCP QW G W +CS TCG GI
Sbjct: 933 TRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGI 991
Query: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
+ R V+C+ + +CE ++P +V C + AC
Sbjct: 992 QQRQVVCRTNANSL---GHCE-GDRPDTVQVCSLPAC 1024
Score = 51.6 bits (122), Expect = 7e-06
Identities = 36/111 (32%), Positives = 48/111 (43%), Gaps = 20/111 (18%)
Query: 1581 KNCRNPPCNYIV-VTADSSQCANNCG-FSYRQRITYCTEIPSTKKHKLHRL------RPI 1632
+ C PC+ V VT + C+ +CG + R C S HK+ RP
Sbjct: 902 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 961
Query: 1633 VYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCIT 1683
+ C VP A W++G WS+CS TCG GI +RQV C T
Sbjct: 962 ARRPCLRVPCP------------AQWRLGAWSQCSATCGEGIQQRQVVCRT 1000
Score = 36.2 bits (82), Expect = 0.32
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 8/55 (14%)
Query: 972 YSEWSQCSRSCGGGERSRESYCMN---NFGHRLADNECQELSRVTRENCNEFSCP 1023
++++ CSRSCGGG RSR C N +G RL E + CN CP
Sbjct: 561 WTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEY-----QVCNSEECP 610
Score = 34.7 bits (78), Expect = 0.92
Identities = 20/69 (28%), Positives = 30/69 (43%), Gaps = 20/69 (28%)
Query: 1341 YCDAASKPP-ELQQCGPGP----------CPQWNYGN---------WGECSQTCGGGIKS 1380
+C PP + +C PG P+ YG +G CS++CGGG++S
Sbjct: 518 FCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 577
Query: 1381 RLVICQFPN 1389
R C P+
Sbjct: 578 RSRSCNNPS 586
Score = 32.3 bits (72), Expect = 4.5
Identities = 25/82 (30%), Positives = 33/82 (40%), Gaps = 12/82 (14%)
Query: 1212 QAGDWSP------CSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLME-QECSLAACP 1264
Q G WS CS SCG G +R C N C + P+ E Q C+ CP
Sbjct: 554 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLC---LGPMFEYQVCNSEECP 610
Query: 1265 PAHSHFPSSPV--QPSYYLSTN 1284
+ F + + SYY+ N
Sbjct: 611 GTYEDFRAQQCAKRNSYYVHQN 632
Score = 32.3 bits (72), Expect = 4.5
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 5/50 (10%)
Query: 1313 WGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPP--ELQQCGPGPCP 1360
+GSCS SC GG++ R+ C N S +Y P E Q C CP
Sbjct: 564 FGSCSRSCGGGVRSRSRSC---NNPSPAYGGRLCLGPMFEYQVCNSEECP 610
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 416 bits (1070), Expect = e-116
Identities = 278/900 (30%), Positives = 421/900 (46%), Gaps = 72/900 (8%)
Query: 127 RHCFYRGQVNSQEDYKAVVSLCGGLTGTFKGQNGEYFLEPIMKADGNEYEDGHNKPHLIY 186
+ C Y G V +S C GL G + + ++F+EP+ + G + ++ + H++Y
Sbjct: 150 QECVYTGGVTGMPGAAVAISNCDGLAGLIRTDSTDFFIEPLER--GQQEKEASGRTHVVY 207
Query: 187 RQDLNNSFLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDER 246
R++ + + E H + DL +LG L D
Sbjct: 208 RRE-------------AVQQEWAEPDGDLHNEAFGLGDL----PNLLGLVGDQ--LGDTE 248
Query: 247 RHSRKKRLISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHI 305
R R + SY IE+++ D VV HG ++QNY+LTLM+IV IY D S+G I+I
Sbjct: 249 RKRRHAKPGSYS--IEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINI 306
Query: 306 VVVKLVMI-HREEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICS 364
+V+L+M+ +R+ + + + +L+ C W +Q D H HHD V +TR+D
Sbjct: 307 ALVRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGP 366
Query: 365 SKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNPRCKEMKV 424
S G + + +C PL+SC +N E G SAF IAHE GH LG++HD +
Sbjct: 367 S-------GYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADET 419
Query: 425 TKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYD 484
+ VMAP + + WS CS+ ++ +L + +CLLD P + + P ELPG Y
Sbjct: 420 SLGSVMAPLVQAAFHRFHWSRCSKLELSRYLPSY--DCLLDDPFDPAWPQPPELPGINYS 477
Query: 485 GNKQCELAFGPGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCR 541
++QC FG G Q C C LWC+ + + C T+ PP DGT+C PG C
Sbjct: 478 MDEQCRFDFGSGYQTCLAFRTFEPCKQLWCSHPDNPYF-CKTKKGPPLDGTECAPGKWCF 536
Query: 542 HGLCVNKETE-TRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRM 600
G C+ K E T +G W W + SCSR+CGGG+ S +R CN P P GG C+G
Sbjct: 537 KGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMF 596
Query: 601 KFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQV 660
+++ CN++ CP +DFR +QC+ N ++ + S W+P Y +C+L CQ
Sbjct: 597 EYQVCNSEECPGTYEDFRAQQCAKRNSYYVHQNAKHS---WVP-YEPDDDAQKCELICQS 652
Query: 661 AGTNYFYLLKDMVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSS 719
A T + +V DGT C + + +C +G+C+ GCD + S DKCGVCGGDNS
Sbjct: 653 ADTGDVVFMNQVVHDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSH 712
Query: 720 CKTITGVFN--SSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGN 777
C+T+ G S G +V+IPAGA ++ I S + + G+F+ N
Sbjct: 713 CRTVKGTLGKASKQAGALKLVQIPAGARHIQIEALEKS---PHRIVVKNQVTGSFILNPK 769
Query: 778 FLLSTSKK--------EINVQGTRTVIEYSG---SNNAVERINSTNRQEKELILQVLCVG 826
+TS+ E V+ + ++ SG A+ + T + + +
Sbjct: 770 GKEATSRTFTAMGLEWEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIH 829
Query: 827 NLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDK 885
P + S N+ LEE D + W W C+K C G+Q C + DH +V
Sbjct: 830 EDLLPLIG-SNNVLLEE-MDTYEW-ALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRH 886
Query: 886 ECDHLPLPSFVTQSCNTD--CELRWHVIGKSECSSQCGQ-GYRTLDIHCMKYSIHEGQTV 942
CDH P + + CN + W CS CG+ G +T I C+ + V
Sbjct: 887 LCDHKKRPKPIRRRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKV 946
Query: 943 QVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYC---MNNFGH 999
GD +P + C +W WSQCS +CG G + R+ C N+ GH
Sbjct: 947 MPAKACAGD--RPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGH 1004
Score = 95.5 bits (236), Expect = 4e-19
Identities = 50/148 (33%), Positives = 75/148 (50%), Gaps = 8/148 (5%)
Query: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFPNGQ-ILEDHNCEIVNKP-PSVIQCHMHACPAD 1418
+W +W CS+ CGGGI+ C+ +++ H C+ +P P +C+ H C
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQP 909
Query: 1419 VSWHQEPWTSCSASCGK-GRKYREVFCI---DQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
V W E W +CS SCGK G + R + C+ K+ +P + C V C
Sbjct: 910 V-WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPC 968
Query: 1475 PS-WKANSWNECSVTCGSGVQQRDVYCR 1501
P+ W+ +W++CS TCG G+QQR V CR
Sbjct: 969 PAQWRLGAWSQCSATCGEGIQQRQVVCR 996
Score = 92.0 bits (227), Expect = 5e-18
Identities = 60/219 (27%), Positives = 89/219 (40%), Gaps = 45/219 (20%)
Query: 1019 EFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPESLSP-CELH 1075
E WA W+ C CG G + + C+ DH + C+ +P+ + C H
Sbjct: 845 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 904
Query: 1076 TCAS--WQVGPWGPCTTTCGH-GYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSC 1129
C+ W WG C+ +CG G Q R ++C+ L++ V+ C RP R+ C
Sbjct: 905 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPC 963
Query: 1130 VLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIA-- 1187
+ PC AQWR G+W+ CS +CG G Q R V CR + +
Sbjct: 964 LRVPCP------------------AQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHC 1005
Query: 1188 -----DESYCAHLPR----------PAEIWDCFTPCGEW 1211
D LP A++W+ TP G+W
Sbjct: 1006 EGDRPDTVQVCSLPACGGNHQNSTVRADVWELGTPEGQW 1044
Score = 91.3 bits (225), Expect = 8e-18
Identities = 55/176 (31%), Positives = 74/176 (42%), Gaps = 16/176 (9%)
Query: 970 WHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNE-CQELSR--VTRENCNEFSC--PS 1024
W W+ CS++CGGG + + C H + C R R CN+ C P
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPV 910
Query: 1025 WAASEWSECLVTCGK-GTKQRQVWCQLNVDH----LSDGFCNSSTKPESLSPCELHTC-A 1078
W EW C +CGK G + R + C L + + + + +PE+ PC C A
Sbjct: 911 WVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCLRVPCPA 970
Query: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
W++G W C+ TCG G Q R V C S C E RP Q C L C
Sbjct: 971 QWRLGAWSQCSATCGEGIQQRQVVCRTNANSL----GHC-EGDRPDTVQVCSLPAC 1021
Score = 85.9 bits (211), Expect = 3e-16
Identities = 65/240 (27%), Positives = 103/240 (42%), Gaps = 25/240 (10%)
Query: 1254 MEQECSLAACPPAHSHFPSSPVQPSYYLSTNL-PLTQKLEDNENQVVHPSVRGNQWRTGP 1312
+ + ++ A PP P S + Y + +L PL N V+ + +W
Sbjct: 802 LPEAIAILALPPTEGG-PRSSLAYKYVIHEDLLPLI-----GSNNVLLEEMDTYEWALKS 855
Query: 1313 WGSCSSSCSGGLQHRAVVC---QDENGQSASYCDAASKP-PELQQCGPGPC--PQWNYGN 1366
W CS +C GG+Q C +D + CD +P P ++C PC P W
Sbjct: 856 WAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCSQPVWVTEE 915
Query: 1367 WGECSQTCGG-GIKSRLVICQFP--NG--QILEDHNCEIVNKPPSVIQCHMHACPADVSW 1421
WG CS++CG G+++R + C P NG +++ C ++P + C CPA W
Sbjct: 916 WGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCPA--QW 972
Query: 1422 HQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANS 1481
W+ CSA+CG+G + R+V C + + +P T + C C NS
Sbjct: 973 RLGAWSQCSATCGEGIQQRQVVC----RTNANSLGHCEGDRPDTVQVCSLPACGGNHQNS 1028
Score = 83.6 bits (205), Expect = 2e-15
Identities = 59/198 (29%), Positives = 79/198 (39%), Gaps = 29/198 (14%)
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFIS 1138
W + W PC+ CG G Q C +++ C RP R+ C PCS
Sbjct: 851 WALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPCS--- 907
Query: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSC----RDALDRIADESYCA 1193
W W CS SCG+ G Q R + C + ++ CA
Sbjct: 908 --------------QPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACA 953
Query: 1194 HLPRPAEIWDCF-TPC-GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
RP C PC +W+ G WS CSA+CG G RQV+C + +C+ + R
Sbjct: 954 G-DRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSL--GHCEGD-R 1009
Query: 1252 PLMEQECSLAACPPAHSH 1269
P Q CSL AC H +
Sbjct: 1010 PDTVQVCSLPACGGNHQN 1027
Score = 80.5 bits (197), Expect = 1e-14
Identities = 63/217 (29%), Positives = 87/217 (40%), Gaps = 56/217 (25%)
Query: 1210 EWQAGDWSPCSASCGHGKTTRQVLCMNY--HQPIDENYCDPEVRPL-MEQECSLAACPPA 1266
EW W+PCS +CG G + C H + + CD + RP + + C+ C
Sbjct: 850 EWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHPC--- 906
Query: 1267 HSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG-GLQ 1325
S PV W T WG+CS SC G+Q
Sbjct: 907 -----SQPV--------------------------------WVTEEWGACSRSCGKLGVQ 929
Query: 1326 HRAVVC--QDENG----QSASYCDAASKPPELQQCGPGPCP-QWNYGNWGECSQTCGGGI 1378
R + C NG A C A +P + C PCP QW G W +CS TCG GI
Sbjct: 930 TRGIQCLLPLSNGTHKVMPAKAC-AGDRPEARRPCLRVPCPAQWRLGAWSQCSATCGEGI 988
Query: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHAC 1415
+ R V+C+ + +CE ++P +V C + AC
Sbjct: 989 QQRQVVCRTNANSL---GHCE-GDRPDTVQVCSLPAC 1021
Score = 51.6 bits (122), Expect = 7e-06
Identities = 36/111 (32%), Positives = 48/111 (43%), Gaps = 20/111 (18%)
Query: 1581 KNCRNPPCNYIV-VTADSSQCANNCG-FSYRQRITYCTEIPSTKKHKLHRL------RPI 1632
+ C PC+ V VT + C+ +CG + R C S HK+ RP
Sbjct: 899 RRCNQHPCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPE 958
Query: 1633 VYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCIT 1683
+ C VP A W++G WS+CS TCG GI +RQV C T
Sbjct: 959 ARRPCLRVPCP------------AQWRLGAWSQCSATCGEGIQQRQVVCRT 997
Score = 36.2 bits (82), Expect = 0.32
Identities = 21/55 (38%), Positives = 27/55 (49%), Gaps = 8/55 (14%)
Query: 972 YSEWSQCSRSCGGGERSRESYCMN---NFGHRLADNECQELSRVTRENCNEFSCP 1023
++++ CSRSCGGG RSR C N +G RL E + CN CP
Sbjct: 558 WTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEY-----QVCNSEECP 607
Score = 34.7 bits (78), Expect = 0.92
Identities = 20/69 (28%), Positives = 30/69 (43%), Gaps = 20/69 (28%)
Query: 1341 YCDAASKPP-ELQQCGPGP----------CPQWNYGN---------WGECSQTCGGGIKS 1380
+C PP + +C PG P+ YG +G CS++CGGG++S
Sbjct: 515 FCKTKKGPPLDGTECAPGKWCFKGHCIWKSPEQTYGQDGGWSSWTKFGSCSRSCGGGVRS 574
Query: 1381 RLVICQFPN 1389
R C P+
Sbjct: 575 RSRSCNNPS 583
Score = 32.3 bits (72), Expect = 4.5
Identities = 25/82 (30%), Positives = 33/82 (40%), Gaps = 12/82 (14%)
Query: 1212 QAGDWSP------CSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLME-QECSLAACP 1264
Q G WS CS SCG G +R C N C + P+ E Q C+ CP
Sbjct: 551 QDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLC---LGPMFEYQVCNSEECP 607
Query: 1265 PAHSHFPSSPV--QPSYYLSTN 1284
+ F + + SYY+ N
Sbjct: 608 GTYEDFRAQQCAKRNSYYVHQN 629
Score = 32.3 bits (72), Expect = 4.5
Identities = 19/50 (38%), Positives = 24/50 (48%), Gaps = 5/50 (10%)
Query: 1313 WGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPP--ELQQCGPGPCP 1360
+GSCS SC GG++ R+ C N S +Y P E Q C CP
Sbjct: 561 FGSCSRSCGGGVRSRSRSC---NNPSPAYGGRLCLGPMFEYQVCNSEECP 607
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 409 bits (1052), Expect = e-113
Identities = 336/1215 (27%), Positives = 484/1215 (39%), Gaps = 213/1215 (17%)
Query: 230 ERVLGHTSKNVPLKD-------ERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNY 282
+ V + S PLK +R+ R++R ++E++V V AH + + Y
Sbjct: 44 QAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERY 103
Query: 283 ILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQND 342
+LT ++I A + +DPS+G + +VK+V++ E P I + ++L + C W QT N
Sbjct: 104 VLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINP 163
Query: 343 LDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIA 402
DD P H D + ITR D+ + G++ LG C P SC I E+ G TIA
Sbjct: 164 EDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIA 223
Query: 403 HELGHTLGVQHDDNPR--CKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYG 460
HE+GH+ G++HD P C HVMA + + +WS CSR+ + L G
Sbjct: 224 HEIGHSFGLEHDGAPGSGCGPSG----HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRA 279
Query: 461 ECLLDKPDEEIYNL---PSELPGSRYDGNKQCELAFGPGSQMCP----HINICMHLWCTS 513
C+ D P + + P PG Y N+QC +AFGP + C H+++C L C +
Sbjct: 280 RCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHT 339
Query: 514 TEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVN--KETETRPVNGEWGPWEPYSSCSRT 571
C VP DGT+CG C G C + + T V+G W W P S CSR+
Sbjct: 340 DPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRS 399
Query: 572 CGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLD 631
CGGG+ + R+CN P P GG CVG ++ CNT +C K +F +QC+ +G+ L
Sbjct: 400 CGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLR 459
Query: 632 IS-GIPSNVRW---LPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTE----- 682
S G S W +P G C+ C+ G ++ D DGT C
Sbjct: 460 SSPGGASFYHWGAAVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPRED 516
Query: 683 -THDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYG-YNVVVKI 740
T +CV G C GCD ++S D+C VCGGDNS+C G F + Y + +
Sbjct: 517 GTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTV 576
Query: 741 PAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSG 800
T+V I + +P ++LA+ G ++ G +S + T
Sbjct: 577 TPNLTSVYIANH----RPLFTHLAVRIG-GRYVVAGKMSISPN----------TTYPSLL 621
Query: 801 SNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCT 860
+ VE + + ++ G PL+E +D+ + YG G
Sbjct: 622 EDGRVEYRVALTEDRLPRLEEIRIWG-------------PLQEDADIQVYRRYGEEYG-- 666
Query: 861 KMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQC 920
L R +IT + P ++V W + + CS C
Sbjct: 667 ----NLTRPDITFTYFQPK-----------PRQAWV-----------WAAV-RGPCSVSC 699
Query: 921 GQGYRTLDIHCMKYSIHE-GQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCS 979
G G R ++ C+ + E +TVQ G Q P E C W ++ CS
Sbjct: 700 GAGLRWVNYSCLDQARKELVETVQCQ----GSQQPPAWPEACVLEPCPPYWAVGDFGPCS 755
Query: 980 RSCGGGERSRESYCMNNFGH---RLADNECQ---ELSRVTRENCNEFSCPS-WAASEWSE 1032
SCGGG R R C+ G L C+ + V E CN CP+ W SE S
Sbjct: 756 ASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
Query: 1033 CLVTCGKGTKQRQVWCQLNVDHL----SDGFCNSSTKPESLSPCELHTCA-SW------- 1080
C G G C D L ++G + K + PC +C W
Sbjct: 816 CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 875
Query: 1081 ----QVGPWGP-----------------CTTTCGHGYQMRDVKCVNELASAVLEDTECHE 1119
PWG C+ +CG G C++ +++ C
Sbjct: 876 AGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGL 935
Query: 1120 ASRP-SDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVS 1178
AS+P S R+ C PC A+W++ CSVSCGRG R +
Sbjct: 936 ASKPGSRREVCQAVPCP------------------ARWQY-KLAACSVSCGRGVVRRILY 976
Query: 1179 C-----RDALDRIADESYCAHLPRPAEIWDC-FTPCG-EWQAGDWSPCSASCGHGKTTRQ 1231
C D + I ++ C LPRP C PC W+ PCSASCG G R
Sbjct: 977 CARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRS 1036
Query: 1232 VLCMNYHQ----PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPL 1287
V C+ Q +DE C VRP C +A C
Sbjct: 1037 VACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT----------------------- 1073
Query: 1288 TQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQS---ASYCDA 1344
+W G W CS SC G+Q R C Q+ A +C
Sbjct: 1074 ------------------YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQH 1115
Query: 1345 ASKPPELQQCGPGPC 1359
KP ++ C GPC
Sbjct: 1116 LPKPVTVRGCWAGPC 1130
Score = 121 bits (303), Expect = 7e-27
Identities = 112/454 (24%), Positives = 179/454 (39%), Gaps = 62/454 (13%)
Query: 1314 GSCSSSCSGGLQHRAVVCQDENGQS---ASYCDAASKPPELQQ-CGPGPCPQ-WNYGNWG 1368
G CS SC GL+ C D+ + C + +PP + C PCP W G++G
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFG 752
Query: 1369 ECSQTCGGGIKSRLVICQFPNGQILE---DHNCEIVNKPPSVI--QCHMHACPADVSWHQ 1423
CS +CGGG++ R V C G +L+ C + P+V C+ CPA W
Sbjct: 753 PCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA--RWEV 810
Query: 1424 EPWTSCSASCGKGRKYREVFCI---DQFQRKLEDTNCSQVQKPPTHKACRSVRC-PSW-- 1477
+SC+++ G G C+ D + + + S +K P + C + C P W
Sbjct: 811 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGH 870
Query: 1478 ----------------------KANSW----NECSVTCGSGVQQRDVYCRLKGVG-QVVE 1510
A+ W CSV+CG G+ + C + V E
Sbjct: 871 LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE 930
Query: 1511 EMCDQSTRPCSQRR-CWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECT-DNQIRQVNE 1568
E+C +++P S+R C + C + CS SC R + + C + E
Sbjct: 931 ELCGLASKPGSRREVCQAVPCPAR--WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEE 988
Query: 1569 IVYNSSTISL----TSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKH 1624
I+ ++ L + C PC C+ +CG +R C ++ +
Sbjct: 989 ILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDV 1048
Query: 1625 KLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCI-- 1682
++ V P + V I C + W VG W +CSV+CG GI +R+ C+
Sbjct: 1049 EVDEAACAAL----VRPEASVPCLIADCTY--RWHVGTWMECSVSCGDGIQRRRDTCLGP 1102
Query: 1683 -TKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTC 1715
+ + +D C + KP + C+A C C
Sbjct: 1103 QAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGAC 1136
Score = 110 bits (275), Expect = 1e-23
Identities = 120/506 (23%), Positives = 178/506 (35%), Gaps = 108/506 (21%)
Query: 1188 DESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQP--IDENY 1245
D ++ P+P + W W A PCS SCG G C++ + ++
Sbjct: 672 DITFTYFQPKPRQAW-------VWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQ 723
Query: 1246 CDPEVRP-LMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVR 1304
C +P + C L CPP
Sbjct: 724 CQGSQQPPAWPEACVLEPCPP--------------------------------------- 744
Query: 1305 GNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQ-----SASYCDAASKPP--ELQQCGPG 1357
W G +G CS+SC GGL+ R V C + G + C A ++ P L+ C P
Sbjct: 745 --YWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQ 802
Query: 1358 PCP-QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCE----IVNKPPSVIQCHM 1412
PCP +W C+ G G+ C P LE E + K P+ C
Sbjct: 803 PCPARWEVSEPSSCTSAGGAGLALENETC-VPGADGLEAPVTEGPGSVDEKLPAPEPCVG 861
Query: 1413 HACP--------------ADVSWHQ--------EPWT----SCSASCGKGRKYREVFCID 1446
+CP A W WT SCS SCG+G C+D
Sbjct: 862 MSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMD 921
Query: 1447 QFQR-KLEDTNCSQVQKPPTHK-ACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRL-- 1502
R +++ C KP + + C++V CP+ CSV+CG GV +R +YC
Sbjct: 922 SALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAH 981
Query: 1503 ---KGVGQVVEEMCDQSTRPCSQRRCWSQDC-VQHKGMERGRLNCSTSCERKDSHQRMEC 1558
G +++ C RP Q C + C + K M G CS SC + + + C
Sbjct: 982 GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLG--PCSASCGLGTARRSVAC 1039
Query: 1559 T---DNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYC 1615
Q +V+E + S C C Y +C+ +CG ++R C
Sbjct: 1040 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1099
Query: 1616 ----TEIPSTKKHKLHRLRPIVYQEC 1637
+ P H +P+ + C
Sbjct: 1100 LGPQAQAPVPADFCQHLPKPVTVRGC 1125
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 409 bits (1052), Expect = e-113
Identities = 336/1215 (27%), Positives = 484/1215 (39%), Gaps = 213/1215 (17%)
Query: 230 ERVLGHTSKNVPLKD-------ERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNY 282
+ V + S PLK +R+ R++R ++E++V V AH + + Y
Sbjct: 44 QAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERY 103
Query: 283 ILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQND 342
+LT ++I A + +DPS+G + +VK+V++ E P I + ++L + C W QT N
Sbjct: 104 VLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINP 163
Query: 343 LDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIA 402
DD P H D + ITR D+ + G++ LG C P SC I E+ G TIA
Sbjct: 164 EDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIA 223
Query: 403 HELGHTLGVQHDDNPR--CKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYG 460
HE+GH+ G++HD P C HVMA + + +WS CSR+ + L G
Sbjct: 224 HEIGHSFGLEHDGAPGSGCGPSG----HVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRA 279
Query: 461 ECLLDKPDEEIYNL---PSELPGSRYDGNKQCELAFGPGSQMCP----HINICMHLWCTS 513
C+ D P + + P PG Y N+QC +AFGP + C H+++C L C +
Sbjct: 280 RCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHT 339
Query: 514 TEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVN--KETETRPVNGEWGPWEPYSSCSRT 571
C VP DGT+CG C G C + + T V+G W W P S CSR+
Sbjct: 340 DPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRS 399
Query: 572 CGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLD 631
CGGG+ + R+CN P P GG CVG ++ CNT +C K +F +QC+ +G+ L
Sbjct: 400 CGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLR 459
Query: 632 IS-GIPSNVRW---LPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTE----- 682
S G S W +P G C+ C+ G ++ D DGT C
Sbjct: 460 SSPGGASFYHWGAAVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPRED 516
Query: 683 -THDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYG-YNVVVKI 740
T +CV G C GCD ++S D+C VCGGDNS+C G F + Y + +
Sbjct: 517 GTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTV 576
Query: 741 PAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSG 800
T+V I + +P ++LA+ G ++ G +S + T
Sbjct: 577 TPNLTSVYIANH----RPLFTHLAVRIG-GRYVVAGKMSISPN----------TTYPSLL 621
Query: 801 SNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCT 860
+ VE + + ++ G PL+E +D+ + YG G
Sbjct: 622 EDGRVEYRVALTEDRLPRLEEIRIWG-------------PLQEDADIQVYRRYGEEYG-- 666
Query: 861 KMCQGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQC 920
L R +IT + P ++V W + + CS C
Sbjct: 667 ----NLTRPDITFTYFQPK-----------PRQAWV-----------WAAV-RGPCSVSC 699
Query: 921 GQGYRTLDIHCMKYSIHE-GQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCS 979
G G R ++ C+ + E +TVQ G Q P E C W ++ CS
Sbjct: 700 GAGLRWVNYSCLDQARKELVETVQCQ----GSQQPPAWPEACVLEPCPPYWAVGDFGPCS 755
Query: 980 RSCGGGERSRESYCMNNFGH---RLADNECQ---ELSRVTRENCNEFSCPS-WAASEWSE 1032
SCGGG R R C+ G L C+ + V E CN CP+ W SE S
Sbjct: 756 ASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSS 815
Query: 1033 CLVTCGKGTKQRQVWCQLNVDHL----SDGFCNSSTKPESLSPCELHTCA-SW------- 1080
C G G C D L ++G + K + PC +C W
Sbjct: 816 CTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATS 875
Query: 1081 ----QVGPWGP-----------------CTTTCGHGYQMRDVKCVNELASAVLEDTECHE 1119
PWG C+ +CG G C++ +++ C
Sbjct: 876 AGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGL 935
Query: 1120 ASRP-SDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVS 1178
AS+P S R+ C PC A+W++ CSVSCGRG R +
Sbjct: 936 ASKPGSRREVCQAVPCP------------------ARWQY-KLAACSVSCGRGVVRRILY 976
Query: 1179 C-----RDALDRIADESYCAHLPRPAEIWDC-FTPCG-EWQAGDWSPCSASCGHGKTTRQ 1231
C D + I ++ C LPRP C PC W+ PCSASCG G R
Sbjct: 977 CARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRS 1036
Query: 1232 VLCMNYHQ----PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPL 1287
V C+ Q +DE C VRP C +A C
Sbjct: 1037 VACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCT----------------------- 1073
Query: 1288 TQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQS---ASYCDA 1344
+W G W CS SC G+Q R C Q+ A +C
Sbjct: 1074 ------------------YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQH 1115
Query: 1345 ASKPPELQQCGPGPC 1359
KP ++ C GPC
Sbjct: 1116 LPKPVTVRGCWAGPC 1130
Score = 166 bits (419), Expect = 3e-40
Identities = 125/473 (26%), Positives = 194/473 (41%), Gaps = 61/473 (12%)
Query: 1086 GPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFISKLETAL 1144
GPC+ +CG G + + C+++ ++E +C + +P ++CVL PC
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCP--------- 743
Query: 1145 LPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDA----LDRIADESYCAHLPRPAE 1200
W G + PCS SCG G + R V C +A L + A +PA
Sbjct: 744 ---------PYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAV 794
Query: 1201 IWDCFTP--C-GEWQAGDWSPCSASCGHGKTTRQVLCM----NYHQPIDENYCDPEVRPL 1253
+ P C W+ + S C+++ G G C+ P+ E + +
Sbjct: 795 ALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLP 854
Query: 1254 MEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPW 1313
+ C +CPP H ++ +K + + + W T
Sbjct: 855 APEPCVGMSCPPGWGHLDATSAG------------EKAPSPWGSIRTGAQAAHVW-TPAA 901
Query: 1314 GSCSSSCSGGLQHRAVVCQDENGQ---SASYCDAASKPPELQQ-CGPGPCP-QWNYGNWG 1368
GSCS SC GL +C D + C ASKP ++ C PCP +W Y
Sbjct: 902 GSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQY-KLA 960
Query: 1369 ECSQTCGGGIKSRLVICQFPNGQ-----ILEDHNCEIVNKPPSVIQCHMHACPADVSWHQ 1423
CS +CG G+ R++ C +G+ IL D C+ + +P C + CP W
Sbjct: 961 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPP--RWKV 1018
Query: 1424 EPWTSCSASCGKGRKYREVFCI--DQFQR-KLEDTNCSQVQKPPTHKACRSVRCP-SWKA 1479
CSASCG G R V C+ DQ Q ++++ C+ + +P C C W
Sbjct: 1019 MSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHV 1078
Query: 1480 NSWNECSVTCGSGVQQR-DVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCV 1531
+W ECSV+CG G+Q+R D + V + C +P + R CW+ CV
Sbjct: 1079 GTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCV 1131
Score = 120 bits (301), Expect = 1e-26
Identities = 111/448 (24%), Positives = 178/448 (39%), Gaps = 62/448 (13%)
Query: 1314 GSCSSSCSGGLQHRAVVCQDENGQS---ASYCDAASKPPELQQ-CGPGPCPQ-WNYGNWG 1368
G CS SC GL+ C D+ + C + +PP + C PCP W G++G
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFG 752
Query: 1369 ECSQTCGGGIKSRLVICQFPNGQILE---DHNCEIVNKPPSVI--QCHMHACPADVSWHQ 1423
CS +CGGG++ R V C G +L+ C + P+V C+ CPA W
Sbjct: 753 PCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA--RWEV 810
Query: 1424 EPWTSCSASCGKGRKYREVFCI---DQFQRKLEDTNCSQVQKPPTHKACRSVRC-PSW-- 1477
+SC+++ G G C+ D + + + S +K P + C + C P W
Sbjct: 811 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGH 870
Query: 1478 ----------------------KANSW----NECSVTCGSGVQQRDVYCRLKGVG-QVVE 1510
A+ W CSV+CG G+ + C + V E
Sbjct: 871 LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE 930
Query: 1511 EMCDQSTRPCSQRR-CWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECT-DNQIRQVNE 1568
E+C +++P S+R C + C + CS SC R + + C + E
Sbjct: 931 ELCGLASKPGSRREVCQAVPCPAR--WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEE 988
Query: 1569 IVYNSSTISL----TSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKH 1624
I+ ++ L + C PC C+ +CG +R C ++ +
Sbjct: 989 ILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDV 1048
Query: 1625 KLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCI-- 1682
++ V P + V I C + W VG W +CSV+CG GI +R+ C+
Sbjct: 1049 EVDEAACAAL----VRPEASVPCLIADCTY--RWHVGTWMECSVSCGDGIQRRRDTCLGP 1102
Query: 1683 -TKHGLSSDLCLNHLKPGAQKKCYANDC 1709
+ + +D C + KP + C+A C
Sbjct: 1103 QAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 117 bits (292), Expect = 1e-25
Identities = 113/465 (24%), Positives = 170/465 (36%), Gaps = 72/465 (15%)
Query: 812 NRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMCQG-LQRRN 870
++ KEL+ V C G+ P + LE + +GP C+ C G L+ R
Sbjct: 712 DQARKELVETVQCQGSQQPPA--WPEACVLEPCPPYWAVGDFGP---CSASCGGGLRERP 766
Query: 871 ITCIHKSDH--SVVSDKECDH-LPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGYRT 926
+ C+ + C P+ ++CN C RW V S C+S G G
Sbjct: 767 VRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLAL 826
Query: 927 LDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHY-----------SEW 975
+ C+ + +G V + K P E C G W + S W
Sbjct: 827 ENETCVPGA--DGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPW 884
Query: 976 SQ-----------------CSRSCGGGERSRESYCMNNFGHRLADNECQELSRVT---RE 1015
CS SCG G CM++ E L+ RE
Sbjct: 885 GSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRRE 944
Query: 1016 NCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQL------NVDHLSDGFCNSSTKPESL 1069
C CP+ + + C V+CG+G +R ++C + L D C +PE
Sbjct: 945 VCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQ 1004
Query: 1070 SPCELHTCAS-WQVGPWGPCTTTCGHGYQMRDVKCV--NELASAVLEDTECHEASRPSDR 1126
C L C W+V GPC+ +CG G R V CV ++ +++ C RP
Sbjct: 1005 EACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEAS 1064
Query: 1127 QSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRI 1186
C++ C++ +W G+W CSVSCG G Q R +C +
Sbjct: 1065 VPCLIADCTY------------------RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQA 1106
Query: 1187 -ADESYCAHLPRPAEIWDCFT-PCGEWQAGDWSPCSASCGHGKTT 1229
+C HLP+P + C+ PC P + G+TT
Sbjct: 1107 PVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVPHEEAAAPGRTT 1151
Score = 110 bits (275), Expect = 1e-23
Identities = 120/506 (23%), Positives = 178/506 (35%), Gaps = 108/506 (21%)
Query: 1188 DESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQP--IDENY 1245
D ++ P+P + W W A PCS SCG G C++ + ++
Sbjct: 672 DITFTYFQPKPRQAW-------VWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQ 723
Query: 1246 CDPEVRP-LMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVR 1304
C +P + C L CPP
Sbjct: 724 CQGSQQPPAWPEACVLEPCPP--------------------------------------- 744
Query: 1305 GNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQ-----SASYCDAASKPP--ELQQCGPG 1357
W G +G CS+SC GGL+ R V C + G + C A ++ P L+ C P
Sbjct: 745 --YWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQ 802
Query: 1358 PCP-QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCE----IVNKPPSVIQCHM 1412
PCP +W C+ G G+ C P LE E + K P+ C
Sbjct: 803 PCPARWEVSEPSSCTSAGGAGLALENETC-VPGADGLEAPVTEGPGSVDEKLPAPEPCVG 861
Query: 1413 HACP--------------ADVSWHQ--------EPWT----SCSASCGKGRKYREVFCID 1446
+CP A W WT SCS SCG+G C+D
Sbjct: 862 MSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMD 921
Query: 1447 QFQR-KLEDTNCSQVQKPPTHK-ACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRL-- 1502
R +++ C KP + + C++V CP+ CSV+CG GV +R +YC
Sbjct: 922 SALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAH 981
Query: 1503 ---KGVGQVVEEMCDQSTRPCSQRRCWSQDC-VQHKGMERGRLNCSTSCERKDSHQRMEC 1558
G +++ C RP Q C + C + K M G CS SC + + + C
Sbjct: 982 GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLG--PCSASCGLGTARRSVAC 1039
Query: 1559 T---DNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYC 1615
Q +V+E + S C C Y +C+ +CG ++R C
Sbjct: 1040 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1099
Query: 1616 ----TEIPSTKKHKLHRLRPIVYQEC 1637
+ P H +P+ + C
Sbjct: 1100 LGPQAQAPVPADFCQHLPKPVTVRGC 1125
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 385 bits (990), Expect = e-106
Identities = 328/1212 (27%), Positives = 473/1212 (39%), Gaps = 238/1212 (19%)
Query: 230 ERVLGHTSKNVPLKD-------ERRHSRKKRLISYPRYIEIMVTADAKVVSAHGSNLQNY 282
+ V + S PLK +R+ R++R ++E++V V AH + + Y
Sbjct: 44 QAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERY 103
Query: 283 ILTLMSIVATIYKDPSIGNLIHIVVVKLVMIHREEEGPVINFDGATTLKNFCSWQQTQND 342
+LT ++I A + +DPS+G + +VK+V++ E P I + ++L + C W QT N
Sbjct: 104 VLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINP 163
Query: 343 LDDVHPSHHDTAVLITREDICSSKEKCNMLGLSYLGTICDPLQSCFINEEKGLISAFTIA 402
DD P H D + ITR D+ + G++ LG C P SC I E+ G TIA
Sbjct: 164 EDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIA 223
Query: 403 HELGHTLGVQHDDNPR--CKEMKVTKYHVMAPALSFHMSPWSWSNCSRKYVTEFLDTGYG 460
HE+GH+ G++HD P C HVMA + + +WS CSR+ + L
Sbjct: 224 HEIGHSFGLEHDGAPGSGCGPSG----HVMASDGAAPRAGLAWSPCSRRQLLSLLSA--- 276
Query: 461 ECLLDKPDEEIYNLPSELPGSRYDGNKQCELAFGPGSQMCP----HINICMHLWCTSTEK 516
N+QC +AFGP + C H+++C L C +
Sbjct: 277 -------------------------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPL 311
Query: 517 LHKGCFTQHVPPADGTDCGPGMHCRHGLCVN--KETETRPVNGEWGPWEPYSSCSRTCGG 574
C VP DGT+CG C G C + + T V+G W W P S CSR+CGG
Sbjct: 312 DQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGG 371
Query: 575 GIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDIS- 633
G+ + R+CN P P GG CVG ++ CNT +C K +F +QC+ +G+ L S
Sbjct: 372 GVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSP 431
Query: 634 GIPSNVRW---LPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTE------TH 684
G S W +P G C+ C+ G ++ D DGT C T
Sbjct: 432 GGASFYHWGAAVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTL 488
Query: 685 DICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYG-YNVVVKIPAG 743
+CV G C GCD ++S D+C VCGGDNS+C G F + Y + +
Sbjct: 489 SLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPN 548
Query: 744 ATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNN 803
T+V I + +P ++LA+ G ++ G +S + T +
Sbjct: 549 LTSVYIANH----RPLFTHLAVRIG-GRYVVAGKMSISPN----------TTYPSLLEDG 593
Query: 804 AVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMC 863
VE + + ++ G PL+E +D+ + YG G
Sbjct: 594 RVEYRVALTEDRLPRLEEIRIWG-------------PLQEDADIQVYRRYGEEYG----- 635
Query: 864 QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQG 923
L R +IT + P ++V W + + CS CG G
Sbjct: 636 -NLTRPDITFTYFQPK-----------PRQAWV-----------WAAV-RGPCSVSCGAG 671
Query: 924 YRTLDIHCMKYSIHE-GQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSC 982
R ++ C+ + E +TVQ G Q P E C W ++ CS SC
Sbjct: 672 LRWVNYSCLDQARKELVETVQCQ----GSQQPPAWPEACVLEPCPPYWAVGDFGPCSASC 727
Query: 983 GGGERSRESYCMNNFGH---RLADNECQ---ELSRVTRENCNEFSCPS-WAASEWSECLV 1035
GGG R R C+ G L C+ + V E CN CP+ W SE S C
Sbjct: 728 GGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTS 787
Query: 1036 TCGKGTKQRQVWCQLNVDHL----SDGFCNSSTKPESLSPCELHTCA-SW---------- 1080
G G C D L ++G + K + PC +C W
Sbjct: 788 AGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGE 847
Query: 1081 -QVGPWGP-----------------CTTTCGHGYQMRDVKCVNELASAVLEDTECHEASR 1122
PWG C+ +CG G C++ +++ C AS+
Sbjct: 848 KAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASK 907
Query: 1123 P-SDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC-- 1179
P S R+ C PC A+W++ CSVSCGRG R + C
Sbjct: 908 PGSRREVCQAVPCP------------------ARWQY-KLAACSVSCGRGVVRRILYCAR 948
Query: 1180 ---RDALDRIADESYCAHLPRPAEIWDC-FTPCG-EWQAGDWSPCSASCGHGKTTRQVLC 1234
D + I ++ C LPRP C PC W+ PCSASCG G R V C
Sbjct: 949 AHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVAC 1008
Query: 1235 MNYHQ----PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQK 1290
+ Q +DE C VRP C +A C
Sbjct: 1009 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCT-------------------------- 1042
Query: 1291 LEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQS---ASYCDAASK 1347
+W G W CS SC G+Q R C Q+ A +C K
Sbjct: 1043 ---------------YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPK 1087
Query: 1348 PPELQQCGPGPC 1359
P ++ C GPC
Sbjct: 1088 PVTVRGCWAGPC 1099
Score = 121 bits (303), Expect = 7e-27
Identities = 112/454 (24%), Positives = 179/454 (39%), Gaps = 62/454 (13%)
Query: 1314 GSCSSSCSGGLQHRAVVCQDENGQS---ASYCDAASKPPELQQ-CGPGPCPQ-WNYGNWG 1368
G CS SC GL+ C D+ + C + +PP + C PCP W G++G
Sbjct: 662 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFG 721
Query: 1369 ECSQTCGGGIKSRLVICQFPNGQILE---DHNCEIVNKPPSVI--QCHMHACPADVSWHQ 1423
CS +CGGG++ R V C G +L+ C + P+V C+ CPA W
Sbjct: 722 PCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPA--RWEV 779
Query: 1424 EPWTSCSASCGKGRKYREVFCI---DQFQRKLEDTNCSQVQKPPTHKACRSVRC-PSW-- 1477
+SC+++ G G C+ D + + + S +K P + C + C P W
Sbjct: 780 SEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGH 839
Query: 1478 ----------------------KANSW----NECSVTCGSGVQQRDVYCRLKGVG-QVVE 1510
A+ W CSV+CG G+ + C + V E
Sbjct: 840 LDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQE 899
Query: 1511 EMCDQSTRPCSQRR-CWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECT-DNQIRQVNE 1568
E+C +++P S+R C + C + CS SC R + + C + E
Sbjct: 900 ELCGLASKPGSRREVCQAVPCPAR--WQYKLAACSVSCGRGVVRRILYCARAHGEDDGEE 957
Query: 1569 IVYNSSTISL----TSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKH 1624
I+ ++ L + C PC C+ +CG +R C ++ +
Sbjct: 958 ILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDV 1017
Query: 1625 KLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCI-- 1682
++ V P + V I C + W VG W +CSV+CG GI +R+ C+
Sbjct: 1018 EVDEAACAAL----VRPEASVPCLIADCTY--RWHVGTWMECSVSCGDGIQRRRDTCLGP 1071
Query: 1683 -TKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTC 1715
+ + +D C + KP + C+A C C
Sbjct: 1072 QAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGAC 1105
Score = 110 bits (275), Expect = 1e-23
Identities = 120/506 (23%), Positives = 178/506 (35%), Gaps = 108/506 (21%)
Query: 1188 DESYCAHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQP--IDENY 1245
D ++ P+P + W W A PCS SCG G C++ + ++
Sbjct: 641 DITFTYFQPKPRQAW-------VWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQ 692
Query: 1246 CDPEVRP-LMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVR 1304
C +P + C L CPP
Sbjct: 693 CQGSQQPPAWPEACVLEPCPP--------------------------------------- 713
Query: 1305 GNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQ-----SASYCDAASKPP--ELQQCGPG 1357
W G +G CS+SC GGL+ R V C + G + C A ++ P L+ C P
Sbjct: 714 --YWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQ 771
Query: 1358 PCP-QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCE----IVNKPPSVIQCHM 1412
PCP +W C+ G G+ C P LE E + K P+ C
Sbjct: 772 PCPARWEVSEPSSCTSAGGAGLALENETC-VPGADGLEAPVTEGPGSVDEKLPAPEPCVG 830
Query: 1413 HACP--------------ADVSWHQ--------EPWT----SCSASCGKGRKYREVFCID 1446
+CP A W WT SCS SCG+G C+D
Sbjct: 831 MSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPAAGSCSVSCGRGLMELRFLCMD 890
Query: 1447 QFQR-KLEDTNCSQVQKPPTHK-ACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRL-- 1502
R +++ C KP + + C++V CP+ CSV+CG GV +R +YC
Sbjct: 891 SALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVVRRILYCARAH 950
Query: 1503 ---KGVGQVVEEMCDQSTRPCSQRRCWSQDC-VQHKGMERGRLNCSTSCERKDSHQRMEC 1558
G +++ C RP Q C + C + K M G CS SC + + + C
Sbjct: 951 GEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMSLG--PCSASCGLGTARRSVAC 1008
Query: 1559 T---DNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYC 1615
Q +V+E + S C C Y +C+ +CG ++R C
Sbjct: 1009 VQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTC 1068
Query: 1616 ----TEIPSTKKHKLHRLRPIVYQEC 1637
+ P H +P+ + C
Sbjct: 1069 LGPQAQAPVPADFCQHLPKPVTVRGC 1094
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 320 bits (819), Expect = 1e-86
Identities = 227/741 (30%), Positives = 335/741 (45%), Gaps = 81/741 (10%)
Query: 569 SRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGK 628
S G G AT+ ++P R+ C+G +++ CNT+ CP+ ++ RE QC+ +N K
Sbjct: 266 SNNHGVGTHGATQSFSQPA-RSTAISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
Query: 629 HLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICV 688
+ W P ++ + +C+L CQ G ++ + V DGTPC ICV
Sbjct: 325 PF----MGRFYEWEP-FAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCDQNGTAICV 379
Query: 689 QGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNS--SHYGYNVVVKIPAGATN 746
GQC + GCD L S +DKCGVCGGDN+ C+ ++GVF + GY+ VV+IP GAT
Sbjct: 380 SGQCKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATK 439
Query: 747 VDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQGTRTVIEYSGSNNAVE 806
++I + S ++YLAL G + NGN+ + K +G T+ Y N
Sbjct: 440 INITEMYKS----NNYLALRSRSGRSIINGNWAIDRPGK---YEGGGTMFTYKRPNEISS 492
Query: 807 RINSTNRQE--KELILQVLCVGNLYNPDVHYSFNI---------------PLEERSDMFT 849
+ E IL V + NP VHY + I P E +
Sbjct: 493 TAGESFLAEGPTNEILDVYMIHQQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMV 552
Query: 850 WDPYGPWEGCTK-------MCQGLQRRNITCIHKSDHSV-VSDKECDHLP--LPSFVTQS 899
+ EG K +G T V D+ H P L Q
Sbjct: 553 TEGRSQEEGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQP 612
Query: 900 CNTDCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKP-PTQ 958
+ W +G +ECS+ CG+G + C+ S HE + + YC +KP P +
Sbjct: 613 PRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHE----EAPESYCDSSMKPTPEE 668
Query: 959 ELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHR---LADNECQELSR-VTR 1014
E C+ W EWS+CS++CG G + R+ C + +R + CQ L + T
Sbjct: 669 EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETT 728
Query: 1015 ENCNEFSCPSW-AASEWSECLVTCGKGTKQRQVWCQLNV-DHLSDGFCNSSTKPESLSPC 1072
C C W ++W+ C V CG G + R V C N+ D + D CN +P + C
Sbjct: 729 STCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENC 788
Query: 1073 ELHTCA-SWQVGPWGP-CTTTCGHGYQMRDVKCV-NELASAVLEDTECHEASRPSDRQSC 1129
++ CA SW + W C+ CG G + R V C+ N ++S LE C +RP++ C
Sbjct: 789 DMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEG--CGN-NRPAEATPC 845
Query: 1130 VLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC-RDALD--RI 1186
PC+ K+E W GSW+ CS+ CG GTQ R V C R D +
Sbjct: 846 DNGPCT--GKVE--------------WFAGSWSQCSIECGSGTQQREVICVRKNADTFEV 889
Query: 1187 ADESYCAHLPRPAEIWDC-FTPCG-EWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDEN 1244
D S C+ L +P C PCG +W + +WS CS SC G R+V C++ + N
Sbjct: 890 LDPSECSFLEKPPSQQSCHLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTL-SN 948
Query: 1245 YCDPEVRPLMEQECSLAACPP 1265
CDP+++P + C+ C P
Sbjct: 949 LCDPQLKPEERESCNPQDCVP 969
Score = 186 bits (472), Expect = 2e-46
Identities = 132/448 (29%), Positives = 185/448 (41%), Gaps = 77/448 (17%)
Query: 954 KPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLA-DNECQELSRV 1012
+PP + H W ++CS +CG G + C++ H A ++ C +
Sbjct: 611 QPPRRSRDHN------WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKP 664
Query: 1013 TREN--CNEFSCPS-WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGF----CNSSTK 1065
T E CN F CP+ W EWSEC TCG G + RQV C+ + S C K
Sbjct: 665 TPEEEPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEK 724
Query: 1066 PESLSPCELHTCASWQVGP-WGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPS 1124
PE+ S C+L C+ WQ+ W C+ CG G + RDVKCV+ + V++D EC+ RP+
Sbjct: 725 PETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD-VVDDEECNMKLRPN 783
Query: 1125 DRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTP-CSVSCGRGTQARYVSCRDAL 1183
D ++C + PC+ W W+ CS CG G + R V C
Sbjct: 784 DIENCDMGPCA------------------KSWFLTEWSERCSAECGAGVRTRSVVCMTNH 825
Query: 1184 DRIADESYCAHLPRPAEIWDCFT-PCG---EWQAGDWSPCSASCGHGKTTRQVLCMNYHQ 1239
C + RPAE C PC EW AG WS CS CG G R+V+C+ +
Sbjct: 826 VSSLPLEGCGN-NRPAEATPCDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNA 884
Query: 1240 PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVV 1299
E DP ECS PP+ Q
Sbjct: 885 DTFE-VLDPS-------ECSFLEKPPSQ-----------------------------QSC 907
Query: 1300 HPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPC 1359
H G +W + W CS SC GG + R V C ++ ++ CD KP E + C P C
Sbjct: 908 HLKPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDC 967
Query: 1360 PQWNYGNWGECSQTCGGGIKSRLVICQF 1387
N + C +++RL + +
Sbjct: 968 VPEVDENCKDKYYNCNVVVQARLCVYNY 995
Score = 151 bits (381), Expect = 7e-36
Identities = 98/352 (27%), Positives = 150/352 (42%), Gaps = 35/352 (9%)
Query: 1211 WQAGDWSPCSASCGHGKTTRQVLCMNY--HQPIDENYCDPEVRPLMEQE-CSLAACPP-- 1265
W+ + CS +CG G C++ H+ E+YCD ++P E+E C++ CP
Sbjct: 621 WKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPCPAFW 680
Query: 1266 ----------------AHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWR 1309
H V + L+ Q LE E ++W+
Sbjct: 681 DIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKICSEWQ 740
Query: 1310 TGP-WGSCSSSCSGGLQHRAVVCQDENGQSAS--YCDAASKPPELQQCGPGPCPQ-WNYG 1365
W SCS C G + R V C G C+ +P +++ C GPC + W
Sbjct: 741 IRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPCAKSWFLT 800
Query: 1366 NWGE-CSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQE 1424
W E CS CG G+++R V+C + L C N+P C C V W
Sbjct: 801 EWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGN-NRPAEATPCDNGPCTGKVEWFAG 859
Query: 1425 PWTSCSASCGKGRKYREVFCI----DQFQRKLEDTNCSQVQKPPTHKACRSVRCPS-WKA 1479
W+ CS CG G + REV C+ D F+ L+ + CS ++KPP+ ++C C + W +
Sbjct: 860 SWSQCSIECGSGTQQREVICVRKNADTFE-VLDPSECSFLEKPPSQQSCHLKPCGAKWFS 918
Query: 1480 NSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCV 1531
W+ CS +C G + R+V C + + +CD +P + C QDCV
Sbjct: 919 TEWSMCSKSCQGGFRVREVRCLSDDM--TLSNLCDPQLKPEERESCNPQDCV 968
Score = 143 bits (360), Expect = 2e-33
Identities = 95/329 (28%), Positives = 144/329 (43%), Gaps = 23/329 (6%)
Query: 1304 RGNQWRTGPWGSCSSSCSGGLQH---RAVVCQDENGQSASYCDAASKP-PELQQCGPGPC 1359
R + W+ CS++C G Q+ R V SYCD++ KP PE + C PC
Sbjct: 617 RDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC 676
Query: 1360 PQ-WNYGNWGECSQTCGGGIKSRLVICQ--FPNGQI-LEDHNCEIVNKPPSVIQCHMHAC 1415
P W+ G W ECS+TCG G++ R V+C+ + N + ++ + C+ + KP + C + C
Sbjct: 677 PAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETTSTCQLKIC 736
Query: 1416 PADVSWH-QEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRC 1474
W + WTSCS CG G++ R+V C+ ++D C+ +P + C C
Sbjct: 737 S---EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC 793
Query: 1475 -PSWKANSWNE-CSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQ 1532
SW W+E CS CG+GV+ R V C V + E C + RP C + C
Sbjct: 794 AKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCG-NNRPAEATPCDNGPCTG 852
Query: 1533 HKGMERGRLN-CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSK-----NCRNP 1586
G + CS C + + C V + S S K +C
Sbjct: 853 KVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFE--VLDPSECSFLEKPPSQQSCHLK 910
Query: 1587 PCNYIVVTADSSQCANNCGFSYRQRITYC 1615
PC + + S C+ +C +R R C
Sbjct: 911 PCGAKWFSTEWSMCSKSCQGGFRVREVRC 939
Score = 139 bits (349), Expect = 3e-32
Identities = 106/380 (27%), Positives = 157/380 (41%), Gaps = 30/380 (7%)
Query: 1347 KPPELQQCGPGPCPQWNYGNWG-----ECSQTCGGGIKSRLVICQFPNG-QILEDHNCEI 1400
+P L P P + NW ECS TCG G + + C + + + C+
Sbjct: 601 RPDNLVPPAPQPPRRSRDHNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDS 660
Query: 1401 VNKP-PSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRK---LEDTN 1456
KP P C++ CPA W W+ CS +CG G ++R+V C + + ++
Sbjct: 661 SMKPTPEEEPCNIFPCPA--FWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYR 718
Query: 1457 CSQVQKPPTHKACRSVRCPSWKANS-WNECSVTCGSGVQQRDVYCRLKGVGQVVE-EMCD 1514
C ++KP T C+ C W+ + W CSV CG G + RDV C + +G VV+ E C+
Sbjct: 719 CQHLEKPETTSTCQLKICSEWQIRTDWTSCSVPCGVGQRTRDVKC-VSNIGDVVDDEECN 777
Query: 1515 QSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVN-EIVYNS 1573
RP C C + + CS C + + C N + + E N+
Sbjct: 778 MKLRPNDIENCDMGPCAKSWFLTEWSERCSAECGAGVRTRSVVCMTNHVSSLPLEGCGNN 837
Query: 1574 STISLTSKNCRNPPCNYIV--VTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRP 1631
T C N PC V SQC+ CG +QR C +
Sbjct: 838 RPAEATP--CDNGPCTGKVEWFAGSWSQCSIECGSGTQQREVICV------RKNADTFEV 889
Query: 1632 IVYQECPVV--PSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSS 1689
+ EC + P SQ + C A W +WS CS +C G R+V+C++ S
Sbjct: 890 LDPSECSFLEKPPSQQSCHLKPCG--AKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLS 947
Query: 1690 DLCLNHLKPGAQKKCYANDC 1709
+LC LKP ++ C DC
Sbjct: 948 NLCDPQLKPEERESCNPQDC 967
Score = 43.1 bits (100), Expect = 0.003
Identities = 15/27 (55%), Positives = 19/27 (70%)
Query: 557 GEWGPWEPYSSCSRTCGGGIESATRRC 583
G WG W P+S+CSR+C GG+ TR C
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 32.3 bits (72), Expect = 4.5
Identities = 11/21 (52%), Positives = 14/21 (66%)
Query: 1311 GPWGSCSSSCSGGLQHRAVVC 1331
GPW +CS SCSGG+ + C
Sbjct: 60 GPWSACSRSCSGGVMEQTRPC 80
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 287 bits (734), Expect = 8e-77
Identities = 233/885 (26%), Positives = 334/885 (37%), Gaps = 209/885 (23%)
Query: 556 NGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQ 615
+G W W P+S CSRTCGGG + RRC + C GR +++R+C+ CP
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAG 86
Query: 616 DFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVED 675
DFR +QCS H D+ WLP + + C L CQ GT L V D
Sbjct: 87 DFRAQQCS----AHNDVKHHGQFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 676 GTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFN---SSHY 732
GT C TE+ D+C+ G C GCDH L S+ K D CGVC GD S+C+ + G + S+
Sbjct: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
Query: 733 GYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEG-----NFLFNGNFLLSTSKKEI 787
+ VV IP G+ ++ + PD YL +G + G FL+ S +
Sbjct: 201 SDDTVVAIPYGSRHIRL----VLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDF 256
Query: 788 NVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDM 847
+ ++ +G A + N + +Q + Y P +H +D
Sbjct: 257 QKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI----FYQPIIH------RWRETDF 306
Query: 848 FTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLP---LPSFVTQSCNTD 903
F C+ C G Q + C + VV+D+ C + P P Q CN D
Sbjct: 307 FP---------CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLD 357
Query: 904 -CEL-----------------RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVD 945
C RW + CSS CG G ++ + C++ I +G V+
Sbjct: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDI-QGHVTSVE 416
Query: 946 DHYCGDQLKPPTQELCH-GNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADN 1004
+ C K P + C+ +C +W EWS C+ +CG G R R C+++ G
Sbjct: 417 EWKCMYTPKMPIAQPCNIFDC--PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGC 474
Query: 1005 ECQELSRVTRENCNEFSC-------------------------------PSWAASEWSEC 1033
+ + E C PS+ WS C
Sbjct: 475 SPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSAC 534
Query: 1034 LVTCGKGTKQRQVWCQL------NVDHLSDGFCNSSTKPESLSPCELHTCA--------- 1078
VTCG GT+ R V CQ+ +V L C KP S C C+
Sbjct: 535 TVTCGVGTQVRIVRCQVLLSFSQSVADLPIDEC-EGPKPASQRACYAGPCSGEIPEFNPD 593
Query: 1079 ----------------SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASR 1122
W+ + C+ +CG G Q V C+N+ E+ C + R
Sbjct: 594 ETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRR 653
Query: 1123 PSD-RQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRD 1181
P +SC L PC A+W G W+PCS++CG G Q R V C
Sbjct: 654 PPQLLKSCNLDPCP------------------ARWEIGKWSPCSLTCGVGLQTRDVFCSH 695
Query: 1182 ALDR-------IADESYCAHLPRPAEIWDC--FTPCGEWQAGDWSPCSASCGHGKTTRQV 1232
L R +ADE P+P+ + C F W W PCS +CG G R+V
Sbjct: 696 LLSREMNETVILADE--LCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREV 753
Query: 1233 LCM-----NYHQPIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPL 1287
LC + E +C +P +Q C CP
Sbjct: 754 LCKQRMADGSFLELPETFCSAS-KPACQQACKKDDCP----------------------- 789
Query: 1288 TQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ 1332
++W W CS+SC G Q R+ +C+
Sbjct: 790 ------------------SEWLLSDWTECSTSCGEGTQTRSAICR 816
Score = 228 bits (581), Expect = 4e-59
Identities = 157/527 (29%), Positives = 237/527 (44%), Gaps = 82/527 (15%)
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECH---EASRPSDR-QSCVLTPCS 1135
W+ + PC+ TCG GYQ+ +C + ++ V+ D CH E +P + Q C L PC
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC--RDALDRIA--DESY 1191
S ++P L + +W WT CS SCG G Q+R VSC D + +E
Sbjct: 361 -ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
Query: 1192 CAHLPR-----PAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYC 1246
C + P+ P I+DC +W A +WSPC+ +CG G R VLC++ H+ + C
Sbjct: 420 CMYTPKMPIAQPCNIFDC----PKWLAQEWSPCTVTCGQGLRYRVVLCID-HRGMHTGGC 474
Query: 1247 DPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPL---TQKLEDNENQVVHPSV 1303
P+ +P +++EC + P + PV+ LP Q+LE+ PS
Sbjct: 475 SPKTKPHIKEECIVPT--PCYKPKEKLPVE------AKLPWFKQAQELEEGAAVSEEPS- 525
Query: 1304 RGNQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDA------ASKPPELQQCGPG 1357
+ W +C+ +C G Q R V CQ S S D KP + C G
Sbjct: 526 ----FIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPASQRACYAG 581
Query: 1358 PCP-------------------------QWNYGNWGECSQTCGGGIKSRLVIC-QFPNGQ 1391
PC W Y + +CS++CGGG++ +V C +
Sbjct: 582 PCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTRE 641
Query: 1392 ILEDHNCEIVNKPPSVIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQR 1450
E++ C +PP +++ C++ CPA W W+ CS +CG G + R+VFC R
Sbjct: 642 PAEENLCVTSRRPPQLLKSCNLDPCPA--RWEIGKWSPCSLTCGVGLQTRDVFCSHLLSR 699
Query: 1451 KLEDT-----NCSQVQKPPTHKACRSVRC-PSWKANSWNECSVTCGSGVQQRDVYCRLKG 1504
++ +T + KP T +AC C P+W W CS TCG GVQ+R+V C+ +
Sbjct: 700 EMNETVILADELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRM 759
Query: 1505 VG----QVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSC 1547
++ E C S +P Q+ C DC + + CSTSC
Sbjct: 760 ADGSFLELPETFCSAS-KPACQQACKKDDC-PSEWLLSDWTECSTSC 804
Score = 194 bits (494), Expect = 5e-49
Identities = 175/633 (27%), Positives = 250/633 (39%), Gaps = 153/633 (24%)
Query: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRL-ADNECQELSRVTR-----ENCNE 1019
+ RW +++ CS +CGGG + + C + +R+ AD C + + CN
Sbjct: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
Query: 1020 FSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCEL-HTCA 1078
CP+ SDG+ + + P +L H
Sbjct: 357 DPCPA-------------------------------SDGY-------KQIMPYDLYHPLP 378
Query: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFIS 1138
W+ PW C+++CG G Q R V CV E D + H S + C+ TP
Sbjct: 379 RWEATPWTACSSSCGGGIQSRAVSCVEE-------DIQGHVTS--VEEWKCMYTP----- 424
Query: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLPRP 1198
+ + I +W W+PC+V+CG+G + R V C D R C+ +P
Sbjct: 425 --KMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCID--HRGMHTGGCSPKTKP 480
Query: 1199 AEIWDCF--TPCGE------------W--QAGD-----------------WSPCSASCGH 1225
+C TPC + W QA + WS C+ +CG
Sbjct: 481 HIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGV 540
Query: 1226 GKTTRQVLC---MNYHQ-----PIDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQP 1277
G R V C +++ Q PIDE C+ +P ++ C C S P
Sbjct: 541 GTQVRIVRCQVLLSFSQSVADLPIDE--CEGP-KPASQRACYAGPC---------SGEIP 588
Query: 1278 SYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVC---QDE 1334
+ L L+D + W + CS SC GG+Q V C Q
Sbjct: 589 EFNPDETDGLFGGLQDFDELY--------DWEYEGFTKCSESCGGGVQEAVVSCLNKQTR 640
Query: 1335 NGQSASYCDAASKPPEL-QQCGPGPCP-QWNYGNWGECSQTCGGGIKSRLVIC------Q 1386
+ C + +PP+L + C PCP +W G W CS TCG G+++R V C +
Sbjct: 641 EPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSRE 700
Query: 1387 FPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFC-- 1444
IL D C KP +V C+ CP +W+ W CS +CG G + REV C
Sbjct: 701 MNETVILADELCR-QPKPSTVQACNRFNCPP--AWYPAQWQPCSRTCGGGVQKREVLCKQ 757
Query: 1445 --IDQFQRKLEDTNCSQVQKPPTHKACRSVRCPS-WKANSWNECSVTCGSGVQQRDVYCR 1501
D +L +T CS KP +AC+ CPS W + W ECS +CG G Q R CR
Sbjct: 758 RMADGSFLELPETFCS-ASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
Query: 1502 --LK-GVGQVVEE-MC-----DQSTRPCSQRRC 1525
LK G+ VV +C S RPC C
Sbjct: 817 KMLKTGLSTVVNSTLCPPLPFSSSIRPCMLATC 849
Score = 156 bits (395), Expect = 2e-37
Identities = 131/502 (26%), Positives = 191/502 (38%), Gaps = 106/502 (21%)
Query: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENG------QSASYCDAASKP-PELQQCGPGP 1358
++WR + CS++C GG Q + C D Q Y KP P+LQ+C P
Sbjct: 299 HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDP 358
Query: 1359 CP------------------QWNYGNWGECSQTCGGGIKSRLVICQFPNGQ----ILEDH 1396
CP +W W CS +CGGGI+SR V C + Q +E+
Sbjct: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
Query: 1397 NCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTN 1456
C K P C++ CP W + W+ C+ +CG+G +YR V CID R +
Sbjct: 419 KCMYTPKMPIAQPCNIFDCP---KWLAQEWSPCTVTCGQGLRYRVVLCIDH--RGMHTGG 473
Query: 1457 CSQVQKPPTHKACR-SVRC-------------------------------PSWKANSWNE 1484
CS KP + C C PS+ +W+
Sbjct: 474 CSPKTKPHIKEECIVPTPCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSA 533
Query: 1485 CSVTCGSGVQQRDVYCRL-----KGVGQVVEEMCDQSTRPCSQRRCWSQDCVQH------ 1533
C+VTCG G Q R V C++ + V + + C+ +P SQR C++ C
Sbjct: 534 CTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECE-GPKPASQRACYAGPCSGEIPEFNP 592
Query: 1534 -------KGME----------RGRLNCSTSCERKDSHQRMECTDNQIRQVNE--IVYNSS 1574
G++ G CS SC + C + Q R+ E + S
Sbjct: 593 DETDGLFGGLQDFDELYDWEYEGFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSR 652
Query: 1575 TISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVY 1634
K+C PC S C+ CG + R +C+ + S + ++ I+
Sbjct: 653 RPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNET----VILA 708
Query: 1635 QECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCL- 1693
E P Q N W +W CS TCG G+ KR+V C + S L L
Sbjct: 709 DELCRQPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELP 768
Query: 1694 ----NHLKPGAQKKCYANDCKS 1711
+ KP Q+ C +DC S
Sbjct: 769 ETFCSASKPACQQACKKDDCPS 790
Score = 146 bits (368), Expect = 2e-34
Identities = 134/520 (25%), Positives = 201/520 (38%), Gaps = 121/520 (23%)
Query: 855 PWEGCTKMCQG-LQRRNITCIHKSDHSVVSDKE---CDHLP-LPSFVTQSCNT-DCELRW 908
PW C+ C G +Q R ++C+ + V+ E C + P +P + Q CN DC +W
Sbjct: 384 PWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMP--IAQPCNIFDCP-KW 440
Query: 909 HVIGKSECSSQCGQGYRTLDIHCMKY-SIHEGQTVQVDDHYCGDQLKPPT---------- 957
S C+ CGQG R + C+ + +H G + ++ PT
Sbjct: 441 LAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPCYKPKEKLP 500
Query: 958 -----------QELCHGNCVFTRWHY--SEWSQCSRSCGGGERSRESYC--MNNFGHRLA 1002
QEL G V + WS C+ +CG G + R C + +F +A
Sbjct: 501 VEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVA 560
Query: 1003 D---NECQELSRVTRENCNEFSCPS-------------------------WAASEWSECL 1034
D +EC+ ++ C C W +++C
Sbjct: 561 DLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCS 620
Query: 1035 VTCGKGTKQRQVWC--QLNVDHLSDGFCNSSTKP-ESLSPCELHTC-ASWQVGPWGPCTT 1090
+CG G ++ V C + + + C +S +P + L C L C A W++G W PC+
Sbjct: 621 ESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSL 680
Query: 1091 TCGHGYQMRDVKCVNELA-----SAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALL 1145
TCG G Q RDV C + L+ + +L D C + +PS Q+C C
Sbjct: 681 TCGVGLQTRDVFCSHLLSREMNETVILADELCRQP-KPSTVQACNRFNCP---------- 729
Query: 1146 PTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIAD-------ESYCAHLPRP 1198
W W PCS +CG G Q R V C+ R+AD E++C+ +P
Sbjct: 730 --------PAWYPAQWQPCSRTCGGGVQKREVLCKQ---RMADGSFLELPETFCS-ASKP 777
Query: 1199 AEIWDCFTPC------GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQP-----IDENYCD 1247
A C C EW DW+ CS SCG G TR +C + ++ C
Sbjct: 778 A----CQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCP 833
Query: 1248 PEVRPLMEQECSLAACP----PAHSHFPSSPVQPSYYLST 1283
P + C LA C P+ H P Y+ T
Sbjct: 834 PLPFSSSIRPCMLATCARPGRPSTKHSPHIAAARKVYIQT 873
Score = 130 bits (327), Expect = 1e-29
Identities = 81/270 (30%), Positives = 125/270 (46%), Gaps = 17/270 (6%)
Query: 824 CVGNL--YNPDVHYSFNIPLEERSDMFTWDPYGPWEGCTKMCQG-LQRRNITCIHKSDHS 880
C G + +NPD L++ +++ W+ Y + C++ C G +Q ++C++K
Sbjct: 583 CSGEIPEFNPDETDGLFGGLQDFDELYDWE-YEGFTKCSESCGGGVQEAVVSCLNKQTRE 641
Query: 881 VVSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHE- 938
+ C P + +SCN D C RW + S CS CG G +T D+ C E
Sbjct: 642 PAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTRDVFCSHLLSREM 701
Query: 939 GQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFG 998
+TV + D C Q KP T + C+ W+ ++W CSR+CGGG + RE C
Sbjct: 702 NETVILADELCR-QPKPSTVQACNRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMA 760
Query: 999 H----RLADNECQELSRVTRENCNEFSCPS-WAASEWSECLVTCGKGTKQRQVWCQLNVD 1053
L + C ++ C + CPS W S+W+EC +CG+GT+ R C+ +
Sbjct: 761 DGSFLELPETFCSASKPACQQACKKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLK 820
Query: 1054 HLSDGFCNSSTKP-----ESLSPCELHTCA 1078
NS+ P S+ PC L TCA
Sbjct: 821 TGLSTVVNSTLCPPLPFSSSIRPCMLATCA 850
Score = 119 bits (299), Expect = 2e-26
Identities = 71/241 (29%), Positives = 119/241 (49%), Gaps = 20/241 (8%)
Query: 908 WHVIGKSECSSQCG-QGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQEL-CHGNC 965
W V + CS+ CG +G + + C+ S +V+ +C +++P Q + C+
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNS------TEVNPAHCAGKVRPAVQPIACNRRD 1544
Query: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCM----NNFGHRLADNECQELSR--VTRENCNE 1019
+RW + WS C+RSCGGG ++R C + ++++ C ++++ V + CN+
Sbjct: 1545 CPSRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
Query: 1020 FSCPSWAASEWSECLVTC---GKGTKQRQVWCQLNVD-HLSDGFCNSSTKPESLSPCELH 1075
C WA S W +C C + RQV+CQ L C++ +P S C
Sbjct: 1605 QLCVEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSE 1664
Query: 1076 TCA-SWQVGPWGPCTTTCG-HGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTP 1133
C+ W+V W CT TCG +G+Q R V+CV+ + + + C RP++ Q C +TP
Sbjct: 1665 ACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITP 1724
Query: 1134 C 1134
C
Sbjct: 1725 C 1725
Score = 104 bits (259), Expect = 9e-22
Identities = 77/307 (25%), Positives = 117/307 (38%), Gaps = 77/307 (25%)
Query: 1211 WQAGDWSPCSASCGH-GKTTRQVLCMNYHQPIDENYCDPEVRPLMEQ-ECSLAACPPAHS 1268
W + CSASCG+ G ++ C+ ++ +C +VRP ++ C+ CP
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCP---- 1546
Query: 1269 HFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRA 1328
++W W +C+ SC GG+Q R
Sbjct: 1547 -------------------------------------SRWMVTSWSACTRSCGGGVQTRR 1569
Query: 1329 VVCQDENGQSAS-------YCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGG---GI 1378
V CQ S A +P + Q C C +W + +WG+C+ C G +
Sbjct: 1570 VTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSWGQCNGPCIGPHLAV 1629
Query: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGK-GR 1437
+ R V CQ +G L C + +P S C AC V W WT C+A+CG G
Sbjct: 1630 QHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEAC--SVHWRVSLWTLCTATCGNYGF 1687
Query: 1438 KYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSW--KANSWNECSVTCGSGVQQ 1495
+ R V C+ T+KA C SW + +W C++T ++
Sbjct: 1688 QSRRVECV----------------HARTNKAVPEHLC-SWGPRPANWQRCNITPCENMEC 1730
Query: 1496 RDV--YC 1500
RD YC
Sbjct: 1731 RDTTRYC 1737
Score = 100 bits (250), Expect = 1e-20
Identities = 76/300 (25%), Positives = 124/300 (41%), Gaps = 55/300 (18%)
Query: 999 HRLADNECQELSRVTRENCNEFSCPS-------------------WAASEWSECLVTCG- 1038
H LA + +++ ++ + EFSC + W+ + C +CG
Sbjct: 1446 HILAAGQILQVANLSGGSQGEFSCLAQNEAGVLMQKASLVIQDYWWSVDRLATCSASCGN 1505
Query: 1039 KGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSP--CELHTCAS-WQVGPWGPCTTTCGHG 1095
+G +Q ++ C LN ++ C +P ++ P C C S W V W CT +CG G
Sbjct: 1506 RGVQQPRLRCLLNSTEVNPAHCAGKVRP-AVQPIACNRRDCPSRWMVTSWSACTRSCGGG 1564
Query: 1096 YQMRDVKC----VNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVLIK 1151
Q R V C + +++ V D A RP D Q+C C
Sbjct: 1565 VQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC----------------- 1607
Query: 1152 KMAQWRHGSWTPCSVSC---GRGTQARYVSCRDALDRIADESYCAHLPRPAEIWDCFTP- 1207
+W SW C+ C Q R V C+ C+ LPRP +C++
Sbjct: 1608 --VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEA 1665
Query: 1208 CG-EWQAGDWSPCSASCG-HGKTTRQVLCMN--YHQPIDENYCDPEVRPLMEQECSLAAC 1263
C W+ W+ C+A+CG +G +R+V C++ ++ + E+ C RP Q C++ C
Sbjct: 1666 CSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
Score = 96.7 bits (239), Expect = 2e-19
Identities = 63/238 (26%), Positives = 104/238 (43%), Gaps = 18/238 (7%)
Query: 1308 WRTGPWGSCSSSCSG-GLQHRAVVCQDENGQ-SASYCDAASKPP-ELQQCGPGPCP-QWN 1363
W +CS+SC G+Q + C + + + ++C +P + C CP +W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 1364 YGNWGECSQTCGGGIKSRLVICQFPNGQ-----ILEDHNCEIVNKPPSVIQCHMHACPAD 1418
+W C+++CGGG+++R V CQ + D ++ +P C+ C
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLC--- 1607
Query: 1419 VSWHQEPWTSCSASC---GKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP 1475
V W W C+ C ++R+VFC + L CS + +P + + C S C
Sbjct: 1608 VEWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACS 1667
Query: 1476 -SWKANSWNECSVTCGS-GVQQRDVYCRLKGVGQVV-EEMCDQSTRPCSQRRCWSQDC 1530
W+ + W C+ TCG+ G Q R V C + V E +C RP + +RC C
Sbjct: 1668 VHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC 1725
Score = 94.4 bits (233), Expect = 1e-18
Identities = 74/261 (28%), Positives = 97/261 (37%), Gaps = 34/261 (13%)
Query: 970 WHYSEWSQCSRSCG--GGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPS-WA 1026
W + CS SCG G ++ R +N+ A + V CN CPS W
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPSRWM 1550
Query: 1027 ASEWSECLVTCGKGTKQRQVWCQ-LNVDHLSDGFCNS-----STKPESLSPCELHTCASW 1080
+ WS C +CG G + R+V CQ L +S N + +P C C W
Sbjct: 1551 VTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCVEW 1610
Query: 1081 QVGPWGPCTTTCGHGY---QMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFI 1137
WG C C + Q R V C L +C RP Q+C CS
Sbjct: 1611 AFSSWGQCNGPCIGPHLAVQHRQVFCQTR-DGITLPSEQCSALPRPVSTQNCWSEACS-- 1667
Query: 1138 SKLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSCRDA-LDRIADESYCAHL 1195
WR WT C+ +CG G Q+R V C A ++ E C+
Sbjct: 1668 ----------------VHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWG 1711
Query: 1196 PRPAEIWDC-FTPCGEWQAGD 1215
PRPA C TPC + D
Sbjct: 1712 PRPANWQRCNITPCENMECRD 1732
Score = 92.8 bits (229), Expect = 3e-18
Identities = 67/279 (24%), Positives = 111/279 (39%), Gaps = 27/279 (9%)
Query: 1362 WNYGNWGECSQTCGG-GIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVS 1420
W+ CS +CG G++ + C + ++ H V I C+ CP+
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNSTEVNPAHCAGKVRPAVQPIACNRRDCPS--R 1548
Query: 1421 WHQEPWTSCSASCGKGRKYREVFC----IDQFQRKLEDTNCSQVQKPPTH-KACRSVRCP 1475
W W++C+ SCG G + R V C + + C+QV K P +AC C
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 1476 SWKANSWNECSVTCGS---GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQ 1532
W +SW +C+ C VQ R V+C+ + + E C RP S + CWS+ C
Sbjct: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSV 1668
Query: 1533 HKGMERGRLNCSTSCERKDSHQRMECTDNQI-RQVNEIVYNSSTISLTSKNCRNPPCNYI 1591
H + L +T +R+EC + + V E + + + C PC
Sbjct: 1669 HWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPC--- 1725
Query: 1592 VVTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLR 1630
++ +C R YC ++ K +L + +
Sbjct: 1726 ----ENMEC--------RDTTRYCEKVKQLKLCQLSQFK 1752
Score = 90.5 bits (223), Expect = 1e-17
Identities = 62/234 (26%), Positives = 97/234 (41%), Gaps = 14/234 (5%)
Query: 859 CTKMC--QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNT-DCELRWHVIGKSE 915
C+ C +G+Q+ + C+ S V+ C P+ +CN DC RW V S
Sbjct: 1499 CSASCGNRGVQQPRLRCLLNSTE--VNPAHCAGKVRPAVQPIACNRRDCPSRWMVTSWSA 1556
Query: 916 CSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEW 975
C+ CG G +T + C K G + V + C K P + W +S W
Sbjct: 1557 CTRSCGGGVQTRRVTCQKLKA-SGISTPVSNDMCTQVAKRPVDTQACNQQLCVEWAFSSW 1615
Query: 976 SQCSRSCGG---GERSRESYCMNNFGHRLADNECQELSR-VTRENCNEFSCP-SWAASEW 1030
QC+ C G + R+ +C G L +C L R V+ +NC +C W S W
Sbjct: 1616 GQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSEACSVHWRVSLW 1675
Query: 1031 SECLVTCGK-GTKQRQVWC--QLNVDHLSDGFCNSSTKPESLSPCELHTCASWQ 1081
+ C TCG G + R+V C + + C+ +P + C + C + +
Sbjct: 1676 TLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITPCENME 1729
Score = 73.9 bits (180), Expect = 1e-12
Identities = 70/277 (25%), Positives = 117/277 (42%), Gaps = 27/277 (9%)
Query: 1418 DVSWHQEPWTSCSASCG-KGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHK-ACRSVRCP 1475
D W + +CSASCG +G + + C+ ++ +C+ +P AC CP
Sbjct: 1488 DYWWSVDRLATCSASCGNRGVQQPRLRCLLN-STEVNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 1476 S-WKANSWNECSVTCGSGVQQRDVYC-RLKGVG---QVVEEMCDQ-STRPCSQRRCWSQD 1529
S W SW+ C+ +CG GVQ R V C +LK G V +MC Q + RP + C Q
Sbjct: 1547 SRWMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQL 1606
Query: 1530 CVQHKGMERGRLNCSTSC---ERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNP 1586
CV+ G+ C+ C H+++ C + ++ ++++NC +
Sbjct: 1607 CVEWAFSSWGQ--CNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPRPVSTQNCWSE 1664
Query: 1587 PCNYIVVTADSSQCANNCG-FSYRQRITYCTEIPSTKKHKLHRL----RPIVYQECPVVP 1641
C+ + + C CG + ++ R C + K H RP +Q C + P
Sbjct: 1665 ACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITP 1724
Query: 1642 SSQVYQCINSCLHLATWKVGKW-------SKCSVTCG 1671
+ +C ++ + K K S+C TCG
Sbjct: 1725 CENM-ECRDTTRYCEKVKQLKLCQLSQFKSRCCGTCG 1760
Score = 56.6 bits (135), Expect = 2e-07
Identities = 63/253 (24%), Positives = 96/253 (37%), Gaps = 34/253 (13%)
Query: 1477 WKANSWNECSVTCGS-GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQR-RCWSQDCVQHK 1534
W + CS +CG+ GVQQ + C L +V C RP Q C +DC +
Sbjct: 1491 WSVDRLATCSASCGNRGVQQPRLRCLLNST-EVNPAHCAGKVRPAVQPIACNRRDCPS-R 1548
Query: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNY--IV 1592
M C+ SC +R+ C + ++ V N + + CN V
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 1593 VTADSS--QCANNC---GFSYRQRITYCTE-----IPSTKKHKLHRLRPIVYQECPVVPS 1642
A SS QC C + + R +C +PS + L R P+ Q C
Sbjct: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGITLPSEQCSALPR--PVSTQNCWSEAC 1666
Query: 1643 SQVYQCINSCLHLATWKVGKWSKCSVTCG-IGIMKRQVKCI---TKHGLSSDLCLNHLKP 1698
S W+V W+ C+ TCG G R+V+C+ T + LC +P
Sbjct: 1667 S------------VHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRP 1714
Query: 1699 GAQKKCYANDCKS 1711
++C C++
Sbjct: 1715 ANWQRCNITPCEN 1727
Score = 49.3 bits (116), Expect = 4e-05
Identities = 83/370 (22%), Positives = 125/370 (33%), Gaps = 55/370 (14%)
Query: 1364 YGNWGECSQTCGGGIKSRLVIC---QFPNGQILEDHNCEIVNKPPSVIQCHMHACPA--D 1418
+G W ECS+TCGGG L C + G+ + C V+ PP C A D
Sbjct: 39 WGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHND 98
Query: 1419 VSWH----------QEPWTSCSASC-GKGRKYREVFCIDQFQRKLEDTNC-SQVQKPPTH 1466
V H +P CS C KG ++ + L+ T C ++
Sbjct: 99 VKHHGQFYEWLPVSNDPDNPCSLKCQAKG----TTLVVELAPKVLDGTRCYTESLDMCIS 154
Query: 1467 KACRSVRCPSWKANSWNE--CSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRR 1524
C+ V C ++ E C V G G R V + K + P R
Sbjct: 155 GLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRH 214
Query: 1525 C-----------WSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQI-RQVNEI--- 1569
+Q E + T S + D +I R +
Sbjct: 215 IRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTAD 274
Query: 1570 ----VYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTK--- 1622
+ NS + T + P + D C+ CG Y+ C ++ S +
Sbjct: 275 FIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA 334
Query: 1623 ----KHKLHRLRP-IVYQECPV--VPSSQVYQCI--NSCLH-LATWKVGKWSKCSVTCGI 1672
+ ++P QEC + P+S Y+ I H L W+ W+ CS +CG
Sbjct: 335 DQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG 394
Query: 1673 GIMKRQVKCI 1682
GI R V C+
Sbjct: 395 GIQSRAVSCV 404
Score = 37.4 bits (85), Expect = 0.14
Identities = 38/167 (22%), Positives = 60/167 (35%), Gaps = 19/167 (11%)
Query: 554 PVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCV--------GRRMKFRSC 605
P E G W P CS TCG G+++ C+ R + + ++C
Sbjct: 667 PARWEIGKWSP---CSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQAC 723
Query: 606 NTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRW-------LPRYSGIGTKDRCKLYC 658
N +CP + + CS G + + R LP +K C+ C
Sbjct: 724 NRFNCPPAWYPAQWQPCSRTCGGGVQKREVLCKQRMADGSFLELPETFCSASKPACQQAC 783
Query: 659 QVAGTNYFYLLKDMVEDGTPCGTETHD-ICVQGQCMAAGCDHVLNSS 704
+ +LL D E T CG T + + + G V+NS+
Sbjct: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNST 830
Score = 31.6 bits (70), Expect = 7.8
Identities = 18/54 (33%), Positives = 24/54 (44%), Gaps = 10/54 (18%)
Query: 1311 GPWGSCSSSCSGGLQH---RAVVCQDENGQSASY--CDAASKPPE-----LQQC 1354
GPW CS +C GG + R + + G++ Y C PPE QQC
Sbjct: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQC 93
>gi|38016904 thrombospondin repeat containing 1 isoform 1 [Homo
sapiens]
Length = 1074
Score = 282 bits (722), Expect = 2e-75
Identities = 204/716 (28%), Positives = 299/716 (41%), Gaps = 101/716 (14%)
Query: 595 CVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRC 654
C G + R+C+ CP D R QC+ FN + + +W P ++ + RC
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF----MGQLYQWEP-FTEVQGSQRC 418
Query: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
+L C+ G ++ + V+DGT C DICV G+C++ GCD +L S + D CGVCG
Sbjct: 419 ELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
Query: 715 GDNSSCKTITGVFNS--SHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNF 772
GD+S+C+ ++G GY ++ IPAGA + I Q +P +YLAL G
Sbjct: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQL----RPSSNYLALRGPGGRS 534
Query: 773 LFNGNFLLSTSKKEINVQGTRTVIEYS------GSNNAVERINSTNRQEKELILQVLCVG 826
+ NGN+ + + + TV Y+ G ++ T + + V +
Sbjct: 535 IINGNWAVDPPG---SYRAGGTVFRYNRPPREEGKGESLSAEGPTTQP-----VDVYMIF 586
Query: 827 NLYNPDVHYSFNI----------------PLEERSDMFTWDPYGPWEGCTKMCQGLQRRN 870
NP V Y + I P + + P P + LQR+
Sbjct: 587 QEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQ- 645
Query: 871 ITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQGYRTLDIH 930
+P P + W +G S CS+ CG+G
Sbjct: 646 --------------VRIPQMPAPPHPRTPLGSPAAY-WKRVGHSACSASCGKGVWRPIFL 690
Query: 931 CMKYSIHEGQTVQVDDHYCGDQLKPPTQ-ELCHGNCVFTRWHYSEWSQCSRSCGGGERSR 989
C+ E ++D+ C +PP E CHG W EW+ CSRSCG G + R
Sbjct: 691 CISRESGE----ELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHR 746
Query: 990 ESYCMNNF---GHRLADNECQELSRVT-RENCNEFSCPSW-AASEWSECLVTCGKGTKQR 1044
+ C F G + C L R ++C C W S WS+C V CG+G + R
Sbjct: 747 QLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSR 806
Query: 1045 QVWC-QLNVDHLSDGFCNSS-TKPESLSPCELHTC-ASWQVGPW-GPCTTTCGHGYQMRD 1100
QV C N D +S+ C S +P S C++ C +W W C+ CG G Q R
Sbjct: 807 QVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRS 866
Query: 1101 VKCVNELASAVLEDTE--------CHEASRPSDRQSCVLTPCSFISKLETALLPTVLIKK 1152
V C+ A+ E C SRP D ++C L PC ++
Sbjct: 867 VVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPC----------------ER 910
Query: 1153 MAQWRHGSWTPCSVSCGRGTQARYVSCRDALD---RIADESYCAHLPRPAEIWDCFTPC- 1208
+W G W CS CG GTQ R + C L + S C+HLPRP + C
Sbjct: 911 TWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC 970
Query: 1209 -GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAAC 1263
W + WSPCS SC G TR+V C++ +Q + C P++RP ++ C+ C
Sbjct: 971 QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTR-CPPQLRPSRKRPCNSQPC 1025
Score = 183 bits (464), Expect = 2e-45
Identities = 132/444 (29%), Positives = 176/444 (39%), Gaps = 87/444 (19%)
Query: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRP-SDRQSCVLTPCSF 1136
A W+ C+ +CG G C++ + L++ C +RP + + C TPC
Sbjct: 666 AYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP- 724
Query: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD---RIADESYCA 1193
W G WT CS SCG GTQ R + CR C
Sbjct: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
Query: 1194 HLPRPAEIWDC-FTPCGEWQAGD-WSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVR 1251
HLPRP C CG W+ G WS CS CG G+ +RQV C+ + DE
Sbjct: 768 HLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNG--DE-------- 817
Query: 1252 PLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNL-PLTQKLEDNENQVVHPSVRGNQWRT 1310
+ EQEC+ S P QP + ++ P T W
Sbjct: 818 -VSEQECA------------SGPPQPPSREACDMGPCT-----------------TAWFH 847
Query: 1311 GPWGS-CSSSCSGGLQHRAVVC----------QDENGQSASY-CDAASKPPELQQCGPGP 1358
W S CS+ C G+Q R+VVC Q E G C S+PP+++ C GP
Sbjct: 848 SDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGP 907
Query: 1359 CPQ---WNYGNWGECSQTCGGGIKSRLVICQFPNG---QILEDHNCEIVNKPPSVIQCHM 1412
C + W G WGECS CG G + R +IC G + NC + +PP++ C
Sbjct: 908 CERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQG 967
Query: 1413 HACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSV 1472
AC W PW+ CS SC G + REV C+ Q T C +P + C S
Sbjct: 968 QACQD--RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTL--STRCPPQLRPSRKRPCNSQ 1023
Query: 1473 RCPSWKANSWNECSVTCGSGVQQR 1496
C + + S C VQ R
Sbjct: 1024 PCSQRPDDQCKDSSPHCPLVVQAR 1047
Score = 179 bits (455), Expect = 2e-44
Identities = 118/414 (28%), Positives = 165/414 (39%), Gaps = 73/414 (17%)
Query: 1147 TVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC--RDALDRIADESYCAHLPRPAEIWDC 1204
T L A W+ + CS SCG+G C R++ + + + S A PA C
Sbjct: 659 TPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
Query: 1205 F-TPCGE-WQAGDWSPCSASCGHGKTTRQVLCMNYH----QPIDENYCDPEVRPLMEQEC 1258
TPC W+AG+W+ CS SCG G RQ+ C + C RP + Q C
Sbjct: 719 HGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSC 778
Query: 1259 SLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTG-PWGSCS 1317
L C W G PW CS
Sbjct: 779 QLRLC------------------------------------------GHWEVGSPWSQCS 796
Query: 1318 SSCSGGLQHRAVVCQDENGQSASYCDAAS---KPPELQQCGPGPCPQ-WNYGNWG-ECSQ 1372
C G + R V C NG S + AS +PP + C GPC W + +W +CS
Sbjct: 797 VRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSSKCSA 856
Query: 1373 TCGGGIKSRLVICQFPNGQIL----------EDHNCEIVNKPPSVIQCHMHACPADVSWH 1422
CG GI+ R V+C +G L +C ++PP + C + C W+
Sbjct: 857 ECGTGIQRRSVVC-LGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWY 915
Query: 1423 QEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT---NCSQVQKPPTHKACRSVRCPS-WK 1478
PW CS+ CG G + R++ C+ + + T NCS + +PP + C+ C W
Sbjct: 916 TGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQACQDRWF 975
Query: 1479 ANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQ 1532
+ W+ CS +C G Q R+V C Q + C RP +R C SQ C Q
Sbjct: 976 STPWSPCSRSCQGGTQTREVQC--LSTNQTLSTRCPPQLRPSRKRPCNSQPCSQ 1027
Score = 159 bits (401), Expect = 3e-38
Identities = 119/442 (26%), Positives = 169/442 (38%), Gaps = 80/442 (18%)
Query: 970 WHYSEWSQCSRSCGGGERSRESYCMNN-FGHRLADNECQELSR--VTRENCNEFSCPS-W 1025
W S CS SCG G C++ G L + C +R + E C+ CP W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 1026 AASEWSECLVTCGKGTKQRQVWCQLNV----DHLSDGFCNSSTKPESLSPCELHTCASWQ 1081
A EW+ C +CG GT+ RQ+ C+ + C +P C+L C W+
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
Query: 1082 VG-PWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL 1140
VG PW C+ CG G + R V+CV V E +P R++C + PC+
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCT----- 842
Query: 1141 ETALLPTVLIKKMAQWRHGSWTP-CSVSCGRGTQARYVSCRD---ALDRIADES------ 1190
W H W+ CS CG G Q R V C AL E+
Sbjct: 843 -------------TAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQ 889
Query: 1191 YCAHLPRPAEIWDC-FTPCGE---WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYC 1246
C RP ++ C PC W G W CS+ CG G R ++C++
Sbjct: 890 SCPTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSK--------- 940
Query: 1247 DPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGN 1306
+ E ++ + P SH P P L+ + Q +
Sbjct: 941 -------LGTEFNVTS-PSNCSHLPRPPA---------------LQPCQGQACQ-----D 972
Query: 1307 QWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGN 1366
+W + PW CS SC GG Q R V C N ++ C +P + C PC Q
Sbjct: 973 RWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLSTRCPPQLRPSRKRPCNSQPCSQRPDDQ 1032
Query: 1367 WGECSQTCGGGIKSRLVICQFP 1388
+ S C +++RL C +P
Sbjct: 1033 CKDSSPHCPLVVQARL--CVYP 1052
Score = 144 bits (364), Expect = 6e-34
Identities = 105/375 (28%), Positives = 156/375 (41%), Gaps = 46/375 (12%)
Query: 859 CTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCN-TDCELRWHVIGKSEC 916
C+ C +G+ R CI + + ++ C P + C+ T C W + C
Sbjct: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSC 735
Query: 917 SSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHY-SEW 975
S CG G + + C + G +V + CG +P + C + W S W
Sbjct: 736 SRSCGPGTQHRQLQCRQEFGGGGSSVPPE--RCGHLPRPNITQSCQLR-LCGHWEVGSPW 792
Query: 976 SQCSRSCGGGERSRESYCMNNFGHRLADNECQE--LSRVTRENCNEFSC-PSWAASEW-S 1031
SQCS CG G+RSR+ C+ N G +++ EC +RE C+ C +W S+W S
Sbjct: 793 SQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWSS 852
Query: 1032 ECLVTCGKGTKQRQVWCQLNVDHLSDG----------FCNSSTKPESLSPCELHTCA--- 1078
+C CG G ++R V C + L G C + ++P + C L C
Sbjct: 853 KCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTW 912
Query: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASA--VLEDTECHEASRPSDRQSCVLTPCSF 1136
W GPWG C++ CG G Q RD+ CV++L + V + C RP Q C C
Sbjct: 913 RWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC-- 970
Query: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLP 1196
+W W+PCS SC GTQ R V C ++ + C
Sbjct: 971 ----------------QDRWFSTPWSPCSRSCQGGTQTREVQCLSTNQTLS--TRCPPQL 1012
Query: 1197 RPAEIWDCFT-PCGE 1210
RP+ C + PC +
Sbjct: 1013 RPSRKRPCNSQPCSQ 1027
Score = 143 bits (361), Expect = 1e-33
Identities = 108/379 (28%), Positives = 139/379 (36%), Gaps = 70/379 (18%)
Query: 1206 TPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYH--QPIDENYCDPEVRPLMEQE-CSLAA 1262
+P W+ S CSASCG G LC++ + +DE C RP E C
Sbjct: 663 SPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTP 722
Query: 1263 CPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG 1322
CPP W G W SCS SC
Sbjct: 723 CPP-----------------------------------------YWEAGEWTSCSRSCGP 741
Query: 1323 GLQHRAVVCQDENGQSAS-----YCDAASKPPELQQCGPGPCPQWNYGN-WGECSQTCGG 1376
G QHR + C+ E G S C +P Q C C W G+ W +CS CG
Sbjct: 742 GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGR 801
Query: 1377 GIKSRLVICQFPNGQILEDHNCEI-VNKPPSVIQCHMHACPADVSWHQEPWTS-CSASCG 1434
G +SR V C NG + + C +PPS C M C +W W+S CSA CG
Sbjct: 802 GQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC--TTAWFHSDWSSKCSAECG 859
Query: 1435 KGRKYREVFCIDQFQR---------KLEDTNCSQVQKPPTHKACRSVRCP---SWKANSW 1482
G + R V C+ +C +PP +AC C W W
Sbjct: 860 TGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACSLGPCERTWRWYTGPW 919
Query: 1483 NECSVTCGSGVQQRDVYCRLK---GVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERG 1539
ECS CGSG Q+RD+ C K C RP + + C Q C Q +
Sbjct: 920 GECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQPCQGQAC-QDRWFSTP 978
Query: 1540 RLNCSTSCERKDSHQRMEC 1558
CS SC+ + ++C
Sbjct: 979 WSPCSRSCQGGTQTREVQC 997
Score = 119 bits (298), Expect = 3e-26
Identities = 96/386 (24%), Positives = 150/386 (38%), Gaps = 38/386 (9%)
Query: 1348 PPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVNKPPS 1406
PP + P W CS +CG G+ + +C +G+ L++ +C +PP+
Sbjct: 654 PPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPA 713
Query: 1407 VIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQF---QRKLEDTNCSQVQK 1462
+ CH CP W WTSCS SCG G ++R++ C +F + C + +
Sbjct: 714 SPEPCHGTPCPP--YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR 771
Query: 1463 PPTHKACRSVRCPSWKANS-WNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQS-TRPC 1520
P ++C+ C W+ S W++CSV CG G + R V C +V E+ C +P
Sbjct: 772 PNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
Query: 1521 SQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQIR---QVNEIVYNSSTIS 1577
S+ C C CS C + + C + E +
Sbjct: 832 SREACDMGPCTTAWFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSC 891
Query: 1578 LTS------KNCRNPPC--NYIVVTADSSQCANNCGFSYRQRITYC-----TEIPSTKKH 1624
T + C PC + T +C++ CG ++R C TE T
Sbjct: 892 PTGSRPPDMRACSLGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPS 951
Query: 1625 KL-HRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCIT 1683
H RP Q C Q C + W WS CS +C G R+V+C++
Sbjct: 952 NCSHLPRPPALQPC------QGQACQD------RWFSTPWSPCSRSCQGGTQTREVQCLS 999
Query: 1684 KHGLSSDLCLNHLKPGAQKKCYANDC 1709
+ S C L+P ++ C + C
Sbjct: 1000 TNQTLSTRCPPQLRPSRKRPCNSQPC 1025
Score = 98.6 bits (244), Expect = 5e-20
Identities = 64/243 (26%), Positives = 104/243 (42%), Gaps = 16/243 (6%)
Query: 850 WDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNT-DCELR 907
W+ PW C+ C +G + R + C+ + VS++EC P ++C+ C
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE-VSEQECASGPPQPPSREACDMGPCTTA 844
Query: 908 W-HVIGKSECSSQCGQGYRTLDIHCM----KYSIHEGQTVQVDDHYCGDQLKPPTQELCH 962
W H S+CS++CG G + + C+ +G+ C +PP C
Sbjct: 845 WFHSDWSSKCSAECGTGIQRRSVVCLGSGAALGPGQGEAGAGTGQSCPTGSRPPDMRACS 904
Query: 963 -GNCVFT-RWHYSEWSQCSRSCGGGERSRESYCMNNFGHRL---ADNECQELSR-VTREN 1016
G C T RW+ W +CS CG G + R+ C++ G + + C L R +
Sbjct: 905 LGPCERTWRWYTGPWGECSSECGSGTQRRDIICVSKLGTEFNVTSPSNCSHLPRPPALQP 964
Query: 1017 CNEFSCPS-WAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELH 1075
C +C W ++ WS C +C GT+ R+V C L+ + C +P PC
Sbjct: 965 CQGQACQDRWFSTPWSPCSRSCQGGTQTREVQC-LSTNQTLSTRCPPQLRPSRKRPCNSQ 1023
Query: 1076 TCA 1078
C+
Sbjct: 1024 PCS 1026
Score = 63.9 bits (154), Expect = 1e-09
Identities = 61/243 (25%), Positives = 89/243 (36%), Gaps = 41/243 (16%)
Query: 1459 QVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEM-CDQST 1517
Q+ PP + WK + CS +CG GV + C + G+ ++E C
Sbjct: 650 QMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGA 709
Query: 1518 RP-CSQRRCWSQDCVQHKGMERGR-LNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSST 1575
RP S C C + E G +CS SC H++++C +
Sbjct: 710 RPPASPEPCHGTPCPPY--WEAGEWTSCSRSCGPGTQHRQLQCRQE---------FGGGG 758
Query: 1576 ISLTSKNCRNPP------------CNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTKK 1623
S+ + C + P C + V + SQC+ CG R R C +
Sbjct: 759 SSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDE- 817
Query: 1624 HKLHRLRPIVYQEC---PVVPSSQVYQCINSCLHLATWKVGKWS-KCSVTCGIGIMKRQV 1679
+ QEC P P S+ + C W WS KCS CG GI +R V
Sbjct: 818 --------VSEQECASGPPQPPSREACDMGPCT--TAWFHSDWSSKCSAECGTGIQRRSV 867
Query: 1680 KCI 1682
C+
Sbjct: 868 VCL 870
Score = 41.6 bits (96), Expect = 0.007
Identities = 14/30 (46%), Positives = 20/30 (66%)
Query: 557 GEWGPWEPYSSCSRTCGGGIESATRRCNRP 586
G WGPW ++SCS+ CG G++ +R C P
Sbjct: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 35.8 bits (81), Expect = 0.41
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1355 GPGPCPQWN-YGNWGECSQTCGGGIKSRLVICQFPNGQI 1392
G GP W + W CSQ CG G++ R CQ P Q+
Sbjct: 40 GQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL 78
Score = 34.3 bits (77), Expect = 1.2
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 13/99 (13%)
Query: 1276 QPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGP---------WGSCSSSCSGGLQH 1326
+P YL L L Q D E H + GP W SCS C G+Q
Sbjct: 7 RPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQR 66
Query: 1327 RAVVCQDENGQSASYCDAASKPPE----LQQCGPGPCPQ 1361
R+ CQ Q +PP L G GP PQ
Sbjct: 67 RSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 269 bits (687), Expect = 2e-71
Identities = 230/868 (26%), Positives = 326/868 (37%), Gaps = 186/868 (21%)
Query: 556 NGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQ 615
+G W W +S CSRTCGGG + RRC G C G+ +++++C+ CP +
Sbjct: 75 DGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDAE 128
Query: 616 DFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVED 675
DFR +QCS +N D+ WLPRY+ C L C G N L V D
Sbjct: 129 DFRAQQCSAYN----DVQYQGHYYEWLPRYNDPAAP--CALKCHAQGQNLVVELAPKVLD 182
Query: 676 GTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSSHYG-- 733
GT C T++ D+C+ G C A GCD L S+AK D CGVC GD S+C+ + G + SH
Sbjct: 183 GTRCNTDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQ-SKSHVSPE 241
Query: 734 --YNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFN--GNFLLSTSKKEINV 789
V+ +P G+ +V I + +S L ++G FN G FL+ + E
Sbjct: 242 KREENVIAVPLGSRSVRITVKGPAHLFIES-KTLQGSKGEHSFNSPGVFLVENTTVEFQR 300
Query: 790 QGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDMFT 849
R + G A + K+ ++Q Y P H ++D F
Sbjct: 301 GSERQTFKIPGPLMADFIFKTRYTAAKDSVVQFF----FYQPISHQ------WRQTDFFP 350
Query: 850 WDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLP---LPSFVTQSCNTD-C 904
CT C G Q + C+ VV D C + P P + C+ D C
Sbjct: 351 ---------CTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPC 401
Query: 905 EL-----------------RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDH 947
RW + CS CG G + C++ S+H G+ +QV++
Sbjct: 402 PSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMH-GEILQVEEW 460
Query: 948 YCGDQLKPPTQELCH-GNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNEC 1006
C KP + C+ +C +W EWSQC+ +CG G R R C+N+ G +
Sbjct: 461 KCMYAPKPKVMQTCNLFDC--PKWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNP 518
Query: 1007 QELSRVTRENCNEFSC-------------------------------PSWAASEWSECLV 1035
Q + E C P++ WS C
Sbjct: 519 QLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACST 578
Query: 1036 TCGKGTKQRQVWCQL------NVDHLSDGFCNSSTKPESLSPCELHTC------------ 1077
TCG G + R+V C++ L + C P PC L C
Sbjct: 579 TCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTE-RPCLLEACDESPASRELDIP 637
Query: 1078 --------ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASR-PSDRQS 1128
W+ + PCT TC G+Q C++ + D+ C R P+ Q+
Sbjct: 638 LPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQA 697
Query: 1129 CVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIAD 1188
C PC +W GSW PCS +CG G Q R V C + A
Sbjct: 698 CNTEPCP------------------PRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAP 739
Query: 1189 ESYC----AHLPRPAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDEN 1244
C H + +DC P G W +W CS +CG G R+V C +
Sbjct: 740 PEECRDEKPHALQACNQFDC--PPG-WHIEEWQQCSRTCGGGTQNRRVTCR-------QL 789
Query: 1245 YCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVR 1304
D L ++ C P A SH + +L+
Sbjct: 790 LTDGSFLNLSDELCQ---GPKASSHKSCARTDCPPHLA---------------------- 824
Query: 1305 GNQWRTGPWGSCSSSCSGGLQHRAVVCQ 1332
G W CS SC G+Q R VCQ
Sbjct: 825 -----VGDWSKCSVSCGVGIQRRKQVCQ 847
Score = 233 bits (594), Expect = 1e-60
Identities = 161/559 (28%), Positives = 247/559 (44%), Gaps = 65/559 (11%)
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECH---EASRPSDR-QSCVLTPCS 1135
W+ + PCT TCG GYQ+ +CV+ V+ D CH E +P + + C + PC
Sbjct: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
Query: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDR----IADESY 1191
+ ++P + + +W H WT CSVSCG G Q R C + +E
Sbjct: 403 SSDGFKE-IMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWK 461
Query: 1192 CAHLPRPAEIWDC-FTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEV 1250
C + P+P + C C +W A +WS C+ +CG G R VLC+N H+ C+P++
Sbjct: 462 CMYAPKPKVMQTCNLFDCPKWIAMEWSQCTVTCGRGLRYRVVLCIN-HRGEHVGGCNPQL 520
Query: 1251 RPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRT 1310
+ +++EC + P + SPV+ L Q+LE+ P+ +
Sbjct: 521 KLHIKEECVIPI--PCYKPKEKSPVEAKLPW---LKQAQELEETRIATEEPT-----FIP 570
Query: 1311 GPWGSCSSSCSGGLQHRAVVC-------QDENGQSASYCDAASKPPE----LQQCGPGPC 1359
PW +CS++C G+Q R V C Q E C+ P E L+ C P
Sbjct: 571 EPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPA 630
Query: 1360 PQ---------------WNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVNK 1403
+ W Y + C+ TC GG + + +C Q + D C++V++
Sbjct: 631 SRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHR 690
Query: 1404 PPSVIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQK 1462
PP++ Q C+ CP WH W CSA+CG G + R+V+C+ + C +K
Sbjct: 691 PPAMSQACNTEPCPP--RWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRD-EK 747
Query: 1463 PPTHKACRSVRC-PSWKANSWNECSVTCGSGVQQRDVYCR-LKGVGQVV---EEMCDQST 1517
P +AC C P W W +CS TCG G Q R V CR L G + +E+C Q
Sbjct: 748 PHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELC-QGP 806
Query: 1518 RPCSQRRCWSQDCVQHKGMERGRLNCSTSC-----ERKDSHQRMECTDNQIRQVNEIVYN 1572
+ S + C DC H + CS SC RK QR+ +I ++E++
Sbjct: 807 KASSHKSCARTDCPPHLAVGDWS-KCSVSCGVGIQRRKQVCQRLAAKGRRI-PLSEMMCR 864
Query: 1573 SSTISLTSKNCRNPPCNYI 1591
++C+ P C+ I
Sbjct: 865 DLPGLPLVRSCQMPECSKI 883
Score = 192 bits (488), Expect = 3e-48
Identities = 166/595 (27%), Positives = 232/595 (38%), Gaps = 124/595 (20%)
Query: 1025 WAASEWSECLVTCGKGTKQRQVWC------QLNVDHLSDGFCNSSTKPESLSPCELHTCA 1078
W +++ C VTCG G + C ++ DH + + L C + C
Sbjct: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
Query: 1079 S------------------WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVL---EDTEC 1117
S W+ PW C+ +CG G Q R CV E + E+ +C
Sbjct: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKC 462
Query: 1118 HEASRPSDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYV 1177
A +P Q+C L C +W W+ C+V+CGRG + R V
Sbjct: 463 MYAPKPKVMQTCNLFDCP-------------------KWIAMEWSQCTVTCGRGLRYRVV 503
Query: 1178 SC---RDALDRIADESYCAHLPRPAEI-WDCFTPCGE--------W--QAGD-------- 1215
C R + H+ I C+ P + W QA +
Sbjct: 504 LCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIAT 563
Query: 1216 ---------WSPCSASCGHGKTTRQVLC---MNYHQP---IDENYCDPEVRPLMEQECSL 1260
WS CS +CG G R+V C + + Q + E C+ P E+ C L
Sbjct: 564 EEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPT-ERPCLL 622
Query: 1261 AACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC 1320
AC SP S L LP ED+E W + C+++C
Sbjct: 623 EACD-------ESPA--SRELDIPLP-----EDSETTY--------DWEYAGFTPCTATC 660
Query: 1321 SGGLQHRAVVC---QDENGQSASYCDAASKPPELQQ-CGPGPCP-QWNYGNWGECSQTCG 1375
GG Q VC Q + + S CD +PP + Q C PCP +W+ G+WG CS TCG
Sbjct: 661 VGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCG 720
Query: 1376 GGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGK 1435
GI++R V C P C KP ++ C+ CP WH E W CS +CG
Sbjct: 721 VGIQTRDVYCLHPGETPAPPEECR-DEKPHALQACNQFDCPP--GWHIEEWQQCSRTCGG 777
Query: 1436 GRKYREVFC----IDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKA-NSWNECSVTCG 1490
G + R V C D L D C Q K +HK+C CP A W++CSV+CG
Sbjct: 778 GTQNRRVTCRQLLTDGSFLNLSDELC-QGPKASSHKSCARTDCPPHLAVGDWSKCSVSCG 836
Query: 1491 SGVQQRDVYC-RLKGVGQVV---EEMCDQSTRPCSQRRCWSQDCVQHKGMERGRL 1541
G+Q+R C RL G+ + E MC R C +C + K + +L
Sbjct: 837 VGIQRRKQVCQRLAAKGRRIPLSEMMCRDLPGLPLVRSCQMPECSKIKSEMKTKL 891
Score = 166 bits (419), Expect = 3e-40
Identities = 147/613 (23%), Positives = 220/613 (35%), Gaps = 194/613 (31%)
Query: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRDA-LDRIADESYCAHLPRPAEI------------ 1201
QWR + PC+V+CG G Q C D L R+ + YC + P +
Sbjct: 342 QWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPC 401
Query: 1202 -----------WDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQ-----PIDENY 1245
+D F P W+ W+ CS SCG G R +C+ ++E
Sbjct: 402 PSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWK 461
Query: 1246 CDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRG 1305
C +P + Q C+L CP
Sbjct: 462 CMYAPKPKVMQTCNLFDCP----------------------------------------- 480
Query: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCG-PGPC----- 1359
+W W C+ +C GL++R V+C + G+ C+ K ++C P PC
Sbjct: 481 -KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCNPQLKLHIKEECVIPIPCYKPKE 539
Query: 1360 --------------------------PQWNYGNWGECSQTCGGGIKSRLVICQ----FPN 1389
P + W CS TCG G++ R V C+ F
Sbjct: 540 KSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQ 599
Query: 1390 GQI-LEDHNCEIVNKPPSVIQCHMHAC-------------PAD----VSWHQEPWTSCSA 1431
+ L + CE K P+ C + AC P D W +T C+A
Sbjct: 600 TETELPEEECE-GPKLPTERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTA 658
Query: 1432 SCGKGRKYREVFCID-QFQRKLEDTNCSQVQKPPT-HKACRSVRCPS-WKANSWNECSVT 1488
+C G + C+ Q Q+ + D+ C V +PP +AC + CP W SW CS T
Sbjct: 659 TCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSAT 718
Query: 1489 CGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCE 1548
CG G+Q RDVYC G E C + +P + + C DC +E + CS +C
Sbjct: 719 CGVGIQTRDVYCLHPGETPAPPEEC-RDEKPHALQACNQFDCPPGWHIEEWQ-QCSRTCG 776
Query: 1549 RKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSY 1608
++R+ C +++ + S ++L+ + C+ P + CA
Sbjct: 777 GGTQNRRVTC--------RQLLTDGSFLNLSDELCQGPKAS------SHKSCART----- 817
Query: 1609 RQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSV 1668
+CP HLA VG WSKCSV
Sbjct: 818 ---------------------------DCPP--------------HLA---VGDWSKCSV 833
Query: 1669 TCGIGIMKRQVKC 1681
+CG+GI +R+ C
Sbjct: 834 SCGVGIQRRKQVC 846
Score = 139 bits (350), Expect = 3e-32
Identities = 136/504 (26%), Positives = 191/504 (37%), Gaps = 116/504 (23%)
Query: 839 IPLEERSDMFTWDPYGPWEGCTKMCQG-LQRRNITCIHKSDHSVVSDKE---CDHLPLPS 894
+P + + W+ + PW C+ C G +QRR+ C+ +S H + E C + P P
Sbjct: 411 MPYDHFQPLPRWE-HNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEWKCMYAPKPK 469
Query: 895 FVTQSCNT-DCELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQL 953
V Q+CN DC +W + S+C+ CG+G R + C+ H G+ V C QL
Sbjct: 470 -VMQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLCIN---HRGEHVGG----CNPQL 520
Query: 954 KPPTQELC------------------------HGNCVFTRWHYSE-------WSQCSRSC 982
K +E C TR E WS CS +C
Sbjct: 521 KLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACSTTC 580
Query: 983 GGGERSRESYC-----MNNFGHRLADNECQELSRVTRENCNEFSCPS------------- 1024
G G + RE C L + EC+ T C +C
Sbjct: 581 GPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPASRELDIPLPE 640
Query: 1025 -------WAASEWSECLVTCGKGTKQRQVWCQLNVDH---LSDGFCNSSTKPESLSP-CE 1073
W + ++ C TC G ++ C L++ ++D C+ +P ++S C
Sbjct: 641 DSETTYDWEYAGFTPCTATCVGGHQEAIAVC-LHIQTQQTVNDSLCDMVHRPPAMSQACN 699
Query: 1074 LHTCAS-WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLT 1132
C W VG WGPC+ TCG G Q RDV C++ EC + +P Q+C
Sbjct: 700 TEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHP-GETPAPPEECRD-EKPHALQACNQF 757
Query: 1133 PCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD-----RIA 1187
C W W CS +CG GTQ R V+CR L ++
Sbjct: 758 DCP------------------PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLS 799
Query: 1188 DESYCAHLPRPAEIWDCF-TPCGEWQA-GDWSPCSASCGHGKTTRQVLCMNY-----HQP 1240
DE P+ + C T C A GDWS CS SCG G R+ +C P
Sbjct: 800 DE--LCQGPKASSHKSCARTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIP 857
Query: 1241 IDENYCD-----PEVRPLMEQECS 1259
+ E C P VR ECS
Sbjct: 858 LSEMMCRDLPGLPLVRSCQMPECS 881
Score = 133 bits (335), Expect = 1e-30
Identities = 124/501 (24%), Positives = 186/501 (37%), Gaps = 119/501 (23%)
Query: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSA---SYC----DAASKPPELQQCGPGP 1358
+QWR + C+ +C GG Q + C D + YC + P+L++C P
Sbjct: 341 HQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDP 400
Query: 1359 CP------------------QWNYGNWGECSQTCGGGIKSRLVIC--QFPNGQIL--EDH 1396
CP +W + W CS +CGGGI+ R +C + +G+IL E+
Sbjct: 401 CPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHGEILQVEEW 460
Query: 1397 NCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQF-------- 1448
C KP + C++ CP W W+ C+ +CG+G +YR V CI+
Sbjct: 461 KCMYAPKPKVMQTCNLFDCP---KWIAMEWSQCTVTCGRGLRYRVVLCINHRGEHVGGCN 517
Query: 1449 -QRKLEDTNCSQVQKP---PTHKACRSVRCPSWK------------------ANSWNECS 1486
Q KL + P P K+ + P K W+ CS
Sbjct: 518 PQLKLHIKEECVIPIPCYKPKEKSPVEAKLPWLKQAQELEETRIATEEPTFIPEPWSACS 577
Query: 1487 VTCGSGVQQRDVYCRL-----KGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMER--- 1538
TCG GVQ R+V CR+ + ++ EE C+ P ++R C + C +
Sbjct: 578 TTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP-TERPCLLEACDESPASRELDI 636
Query: 1539 ---------------GRLNCSTSCERKDSHQRMECTDNQIRQ-VNEIVYNS-STISLTSK 1581
G C+ +C C Q +Q VN+ + + S+
Sbjct: 637 PLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLHIQTQQTVNDSLCDMVHRPPAMSQ 696
Query: 1582 NCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCT---EIPS----TKKHKLHRLRPIVY 1634
C PC C+ CG + R YC E P+ + K H L+
Sbjct: 697 ACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQ 756
Query: 1635 QECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKC--ITKHG----LS 1688
+CP W + +W +CS TCG G R+V C + G LS
Sbjct: 757 FDCP-----------------PGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLS 799
Query: 1689 SDLCLNHLKPGAQKKCYANDC 1709
+LC K + K C DC
Sbjct: 800 DELCQGP-KASSHKSCARTDC 819
Score = 121 bits (304), Expect = 6e-27
Identities = 93/328 (28%), Positives = 141/328 (42%), Gaps = 46/328 (14%)
Query: 855 PWEGCTKMC-QGLQRRNITC----IHKSDHSVVSDKECDHLPLPS---FVTQSCNTDCEL 906
PW C+ C G+Q R + C + + ++EC+ LP+ + ++C+
Sbjct: 572 PWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLPTERPCLLEACDESPAS 631
Query: 907 R---------------WHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGD 951
R W G + C++ C G++ C+ I QTV +D C
Sbjct: 632 RELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEAIAVCLH--IQTQQTV--NDSLCDM 687
Query: 952 QLKPPTQ-ELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELS 1010
+PP + C+ RWH W CS +CG G ++R+ YC++ EC++
Sbjct: 688 VHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCLHPGETPAPPEECRDEK 747
Query: 1011 RVTRENCNEFSC-PSWAASEWSECLVTCGKGTKQRQVWC-QLNVD----HLSDGFCN--- 1061
+ CN+F C P W EW +C TCG GT+ R+V C QL D +LSD C
Sbjct: 748 PHALQACNQFDCPPGWHIEEWQQCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPK 807
Query: 1062 -SSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASA---VLEDTEC 1117
SS K + + C H VG W C+ +CG G Q R C A L + C
Sbjct: 808 ASSHKSCARTDCPPHLA----VGDWSKCSVSCGVGIQRRKQVCQRLAAKGRRIPLSEMMC 863
Query: 1118 HEASRPSDRQSCVLTPCSFI-SKLETAL 1144
+ +SC + CS I S+++T L
Sbjct: 864 RDLPGLPLVRSCQMPECSKIKSEMKTKL 891
Score = 107 bits (267), Expect = 1e-22
Identities = 74/265 (27%), Positives = 106/265 (40%), Gaps = 42/265 (15%)
Query: 954 KPPTQELCHGNCVFTRWHYSEWSQCSRSCGG-GERSRESYCMNNFGHRLADNECQELSRV 1012
+PP QE W WS CS +CG G R + C+ G +++ C L +
Sbjct: 1420 EPPPQE--------PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKP 1471
Query: 1013 TR--ENCNEFSCPS-WAASEWSECLVTCGKGTKQRQVWCQLN-----VDHLSDGFCNSST 1064
E CN CP+ W S WS+C V+CG+G RQV C+ V +S C
Sbjct: 1472 LAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKD 1531
Query: 1065 KPESLSPCELHTCASWQVGPWGPCTTTC-GHGYQMRDVKCVNELASAVLEDTECHEASRP 1123
+P PC H C W+ P C C G +M+ + S+ D+ C + RP
Sbjct: 1532 RPLGRKPCFGHPCVQWE--PGNRCPGRCMGRAVRMQQRHTACQHNSS---DSNCDDRKRP 1586
Query: 1124 SDRQSCVLTPCSFISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDAL 1183
+ R++C C W G W PC+ +CGRG Q+R V C
Sbjct: 1587 TLRRNCTSGACDVC------------------WHTGPWKPCTAACGRGFQSRKVDCIHTR 1628
Query: 1184 D-RIADESYCAHLPRPAEIWDCFTP 1207
+ + +C +P C P
Sbjct: 1629 SCKPVAKRHCVQKKKPISWRHCLGP 1653
Score = 106 bits (264), Expect = 2e-22
Identities = 79/268 (29%), Positives = 106/268 (39%), Gaps = 33/268 (12%)
Query: 1308 WRTGPWGSCSSSCSG-GLQHRAVVCQDENGQ--SASYCDAASKP-PELQQCGPGPCP-QW 1362
W G W CS++C G + + C NGQ S + CD KP + C CP +W
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARW 1487
Query: 1363 NYGNWGECSQTCGGGIKSRLVICQ--FPNG--QILEDHNCEIVNKPPSVIQCHMHACPAD 1418
W +CS +CG G SR V C+ NG Q++ C ++P C H C
Sbjct: 1488 FTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC--- 1544
Query: 1419 VSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP-SW 1477
V W EP C C GR R Q D+NC ++P + C S C W
Sbjct: 1545 VQW--EPGNRCPGRC-MGRAVRMQQRHTACQHNSSDSNCDDRKRPTLRRNCTSGACDVCW 1601
Query: 1478 KANSWNECSVTCGSGVQQRDVYC-RLKGVGQVVEEMCDQSTRPCSQRRCWSQDC------ 1530
W C+ CG G Q R V C + V + C Q +P S R C C
Sbjct: 1602 HTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSCDRDCTD 1661
Query: 1531 -------VQHK---GMERGRLNCSTSCE 1548
V+H ++R + C SC+
Sbjct: 1662 TTHYCMFVKHLNLCSLDRYKQRCCQSCQ 1689
Score = 105 bits (263), Expect = 3e-22
Identities = 80/277 (28%), Positives = 107/277 (38%), Gaps = 62/277 (22%)
Query: 1211 WQAGDWSPCSASCGH--GKTTRQVLCMNYHQPIDENYCDPEVRPLMEQE-CSLAACPPAH 1267
W+ G+WS CSA+CGH + R M Q + E CD +PL E C++ CP
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA-- 1485
Query: 1268 SHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHR 1327
+W T W CS SC G R
Sbjct: 1486 ---------------------------------------RWFTSVWSQCSVSCGEGYHSR 1506
Query: 1328 AVVCQ--DENGQ----SASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGG---I 1378
V C+ NG S C +P + C PC QW GN C C G +
Sbjct: 1507 QVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGN--RCPGRCMGRAVRM 1564
Query: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRK 1438
+ R CQ + D NC+ +P C AC DV WH PW C+A+CG+G +
Sbjct: 1565 QQRHTACQHNSS----DSNCDDRKRPTLRRNCTSGAC--DVCWHTGPWKPCTAACGRGFQ 1618
Query: 1439 YREVFCIDQFQRK-LEDTNCSQVQKPPTHKACRSVRC 1474
R+V CI K + +C Q +KP + + C C
Sbjct: 1619 SRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 104 bits (259), Expect = 9e-22
Identities = 69/254 (27%), Positives = 106/254 (41%), Gaps = 37/254 (14%)
Query: 1023 PSWAASEWSECLVTCGK-GTKQRQVWCQL-NVDHLSDGFCNSSTKP-ESLSPCELHTC-A 1078
P W WS C TCG G + ++ C + N +S+ C+ KP PC + C A
Sbjct: 1426 PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA 1485
Query: 1079 SWQVGPWGPCTTTCGHGYQMRDVKCVNELASA---VLEDTECHEASRPSDRQSCVLTPCS 1135
W W C+ +CG GY R V C A+ V+ C RP R+ C PC
Sbjct: 1486 RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC- 1544
Query: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGT--QARYVSCRDALDRIADESYCA 1193
QW G+ P GR Q R+ +C+ + +S C
Sbjct: 1545 ------------------VQWEPGNRCP-GRCMGRAVRMQQRHTACQHN----SSDSNCD 1581
Query: 1194 HLPRPAEIWDCFTPCGE--WQAGDWSPCSASCGHGKTTRQVLCMNYH--QPIDENYCDPE 1249
RP +C + + W G W PC+A+CG G +R+V C++ +P+ + +C +
Sbjct: 1582 DRKRPTLRRNCTSGACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQK 1641
Query: 1250 VRPLMEQECSLAAC 1263
+P+ + C +C
Sbjct: 1642 KKPISWRHCLGPSC 1655
Score = 92.8 bits (229), Expect = 3e-18
Identities = 72/239 (30%), Positives = 98/239 (41%), Gaps = 23/239 (9%)
Query: 908 WHVIGKSECSSQCGQ-GYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQ--ELCHGN 964
W S CS+ CG G R C+ + GQ +V + C D L+ P E C+
Sbjct: 1428 WEPGNWSHCSATCGHLGARIQRPQCV---MANGQ--EVSEALC-DHLQKPLAGFEPCNIR 1481
Query: 965 CVFTRWHYSEWSQCSRSCGGGERSRESYCM----NNFGHRLADNECQELSR-VTRENCNE 1019
RW S WSQCS SCG G SR+ C N ++ C R + R+ C
Sbjct: 1482 DCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFG 1541
Query: 1020 FSCPSWAASEWSECLVTC-GKGTK--QRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHT 1076
C W + C C G+ + QR CQ N SD C+ +P C
Sbjct: 1542 HPCVQWEPG--NRCPGRCMGRAVRMQQRHTACQHNS---SDSNCDDRKRPTLRRNCTSGA 1596
Query: 1077 C-ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
C W GPW PCT CG G+Q R V C++ + + C + +P + C+ C
Sbjct: 1597 CDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 90.9 bits (224), Expect = 1e-17
Identities = 68/244 (27%), Positives = 102/244 (41%), Gaps = 30/244 (12%)
Query: 1326 HRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGG-GIKSRLVI 1384
H+ + Q N ++ S PP+ P W GNW CS TCG G + +
Sbjct: 1400 HKKYILQATNTRTNSNDPTGEPPPQE--------PFWEPGNWSHCSATCGHLGARIQRPQ 1451
Query: 1385 CQFPNGQILEDHNCEIVNKPPSVIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVF 1443
C NGQ + + C+ + KP + + C++ CPA W W+ CS SCG+G R+V
Sbjct: 1452 CVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA--RWFTSVWSQCSVSCGEGYHSRQVT 1509
Query: 1444 C----IDQFQRKLEDTNCSQVQKPPTHKACRSVRCPSWKANSWNECSVTC-GSGV--QQR 1496
C + + + C+ +P K C C W+ N C C G V QQR
Sbjct: 1510 CKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPG--NRCPGRCMGRAVRMQQR 1567
Query: 1497 DVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDC--VQHKGMERGRLNCSTSCERKDSHQ 1554
C+ + CD RP +R C S C H G + C+ +C R +
Sbjct: 1568 HTACQHNS----SDSNCDDRKRPTLRRNCTSGACDVCWHTGPWK---PCTAACGRGFQSR 1620
Query: 1555 RMEC 1558
+++C
Sbjct: 1621 KVDC 1624
Score = 90.1 bits (222), Expect = 2e-17
Identities = 68/239 (28%), Positives = 100/239 (41%), Gaps = 22/239 (9%)
Query: 850 WDPYGPWEGCTKMCQGLQRR--NITCIHKSDHSVVSDKECDHLPLPSFVTQSCNT-DCEL 906
W+P G W C+ C L R C+ + V S+ CDHL P + CN DC
Sbjct: 1428 WEP-GNWSHCSATCGHLGARIQRPQCVMANGQEV-SEALCDHLQKPLAGFEPCNIRDCPA 1485
Query: 907 RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGN-C 965
RW S+CS CG+GY + + C K + G V C + +P ++ C G+ C
Sbjct: 1486 RWFTSVWSQCSVSCGEGYHSRQVTC-KRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Query: 966 VFTRWHYSEWSQCSRSCGGGE---RSRESYCMNNFGHRLADNECQELSRVT-RENCNEFS 1021
V + ++C C G + R + C H +D+ C + R T R NC +
Sbjct: 1545 V----QWEPGNRCPGRCMGRAVRMQQRHTACQ----HNSSDSNCDDRKRPTLRRNCTSGA 1596
Query: 1022 CP-SWAASEWSECLVTCGKGTKQRQVWC--QLNVDHLSDGFCNSSTKPESLSPCELHTC 1077
C W W C CG+G + R+V C + ++ C KP S C +C
Sbjct: 1597 CDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHCLGPSC 1655
Score = 89.4 bits (220), Expect = 3e-17
Identities = 68/270 (25%), Positives = 111/270 (41%), Gaps = 21/270 (7%)
Query: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGK-GR 1437
+SR+V Q IL+ N + P+ P + W W+ CSA+CG G
Sbjct: 1391 ESRIVFLQGHKKYILQATNTRTNSNDPTG-----EPPPQEPFWEPGNWSHCSATCGHLGA 1445
Query: 1438 KYREVFCIDQFQRKLEDTNCSQVQKPPT-HKACRSVRCPS-WKANSWNECSVTCGSGVQQ 1495
+ + C+ +++ + C +QKP + C CP+ W + W++CSV+CG G
Sbjct: 1446 RIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPARWFTSVWSQCSVSCGEGYHS 1505
Query: 1496 RDVYC---RLKGVGQVVE-EMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKD 1551
R V C + G QVV C RP ++ C+ CVQ + R C C +
Sbjct: 1506 RQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPCVQWEPGNR----CPGRCMGRA 1561
Query: 1552 SHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQR 1611
+ T Q + + +L +NC + C+ T C CG ++ R
Sbjct: 1562 VRMQQRHTACQHNSSDSNCDDRKRPTL-RRNCTSGACDVCWHTGPWKPCTAACGRGFQSR 1620
Query: 1612 ITYCTEI----PSTKKHKLHRLRPIVYQEC 1637
C P K+H + + +PI ++ C
Sbjct: 1621 KVDCIHTRSCKPVAKRHCVQKKKPISWRHC 1650
Score = 76.3 bits (186), Expect = 3e-13
Identities = 78/350 (22%), Positives = 128/350 (36%), Gaps = 77/350 (22%)
Query: 1406 SVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCID-QFQRKLEDTNC----SQV 1460
SV+Q + P W Q + C+ +CG G + C+D + +R + D C V
Sbjct: 329 SVVQFFFYQ-PISHQWRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENV 387
Query: 1461 QKPPTHKACRSVRCPS------------------WKANSWNECSVTCGSGVQQRDVYCRL 1502
+ P K C CPS W+ N W CSV+CG G+Q+R C
Sbjct: 388 KPKPKLKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVE 447
Query: 1503 KG----VGQVVEEMCDQSTRPCSQRRCWSQDCVQHKGMERGRLNCSTSCERKDSHQRMEC 1558
+ + QV E C + +P + C DC + ME + C+ +C R ++ + C
Sbjct: 448 ESMHGEILQVEEWKCMYAPKPKVMQTCNLFDCPKWIAMEWSQ--CTVTCGRGLRYRVVLC 505
Query: 1559 TDNQIRQVNEIVYNSSTISLTSKNCRNP-PCNYIVVTADSSQCANNCGFSYRQRITYCTE 1617
+++ V N + C P PC + +++ +
Sbjct: 506 INHRGEHVGGC--NPQLKLHIKEECVIPIPC-----------------YKPKEKSPVEAK 546
Query: 1618 IPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKR 1677
+P K+ + I +E +P WS CS TCG G+ R
Sbjct: 547 LPWLKQAQELEETRIATEEPTFIPE-------------------PWSACSTTCGPGVQVR 587
Query: 1678 QVKC-------ITKHGLSSDLCLNHLKPGAQKKCYANDCKSFTTCKEIQV 1720
+VKC T+ L + C P ++ C C +E+ +
Sbjct: 588 EVKCRVLLTFTQTETELPEEECEGPKLP-TERPCLLEACDESPASRELDI 636
Score = 65.5 bits (158), Expect = 5e-10
Identities = 59/247 (23%), Positives = 92/247 (37%), Gaps = 29/247 (11%)
Query: 1475 PSWKANSWNECSVTCGS-GVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQ-RRCWSQDCVQ 1532
P W+ +W+ CS TCG G + + C + +V E +CD +P + C +DC
Sbjct: 1426 PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEALCDHLQKPLAGFEPCNIRDCPA 1485
Query: 1533 HKGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTIS----LTSKNCRNPPC 1588
+ CS SC +++ C + ++V + L K C PC
Sbjct: 1486 -RWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLGRKPCFGHPC 1544
Query: 1589 NYIVVTADSSQCANNC---GFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQV 1645
V ++C C +QR T C S+ + R RP + + C S
Sbjct: 1545 ---VQWEPGNRCPGRCMGRAVRMQQRHTACQH-NSSDSNCDDRKRPTLRRNCT---SGAC 1597
Query: 1646 YQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHG---LSSDLCLNHLKPGAQK 1702
C W G W C+ CG G R+V CI ++ C+ KP + +
Sbjct: 1598 DVC---------WHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWR 1648
Query: 1703 KCYANDC 1709
C C
Sbjct: 1649 HCLGPSC 1655
Score = 50.8 bits (120), Expect = 1e-05
Identities = 35/144 (24%), Positives = 52/144 (36%), Gaps = 29/144 (20%)
Query: 855 PWEGCTKMCQG----LQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHV 910
P C C G +Q+R+ C H S SD CD P+ + C++ WH
Sbjct: 1549 PGNRCPGRCMGRAVRMQQRHTACQHNS-----SDSNCDDRKRPTLRRNCTSGACDVCWHT 1603
Query: 911 IGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRW 970
C++ CG+G+++ + C IH V +C + KP W
Sbjct: 1604 GPWKPCTAACGRGFQSRKVDC----IHTRSCKPVAKRHCVQKKKP------------ISW 1647
Query: 971 HYSEWSQCSRSCGGGERSRESYCM 994
+ C R C YCM
Sbjct: 1648 RHCLGPSCDRDC----TDTTHYCM 1667
Score = 41.2 bits (95), Expect = 0.010
Identities = 59/242 (24%), Positives = 78/242 (32%), Gaps = 53/242 (21%)
Query: 462 CLLDKPDEEIYNLPSELP---------GSRYDGNKQCELAFGPGSQMCPHINICMHLWCT 512
CLL+ DE + ++P Y G C G Q I +C+H+
Sbjct: 620 CLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVGGHQEA--IAVCLHIQTQ 677
Query: 513 STEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTC 572
T C H PPA C TE P G W P CS TC
Sbjct: 678 QTVN-DSLCDMVHRPPAMSQACN--------------TEPCPPRWHVGSWGP---CSATC 719
Query: 573 GGGIESATRRCNRP-EPRNGGNYCVGRR-MKFRSCNTDSCPKGTQDFREKQCSDFNGKHL 630
G GI++ C P E C + ++CN CP G +QCS
Sbjct: 720 GVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEEWQQCS------- 772
Query: 631 DISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQG 690
R G GT++R Q+ F L D + G +H C +
Sbjct: 773 -------------RTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPK--ASSHKSCART 817
Query: 691 QC 692
C
Sbjct: 818 DC 819
Score = 38.9 bits (89), Expect = 0.049
Identities = 26/78 (33%), Positives = 31/78 (39%), Gaps = 11/78 (14%)
Query: 1341 YCDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEI 1400
Y D S+ + G W G+W +CS+TCGGG L C L NCE
Sbjct: 60 YDDQTSRNTRSDEDKDGNWDAW--GDWSDCSRTCGGGASYSLRRC-------LTGRNCEG 110
Query: 1401 VNKPPSVIQCHMHACPAD 1418
N C H CP D
Sbjct: 111 QNIRYKT--CSNHDCPPD 126
Score = 33.1 bits (74), Expect = 2.7
Identities = 21/76 (27%), Positives = 28/76 (36%), Gaps = 14/76 (18%)
Query: 1661 GKWSKCSVTCGIGIMKRQVKCITKHGLSSD-----LCLNHLKPGAQKKCYANDCKSFTTC 1715
G WS CS TCG G +C+T C NH P + A C ++
Sbjct: 82 GDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQCSAY--- 138
Query: 1716 KEIQVKNHIRKDGDYY 1731
N ++ G YY
Sbjct: 139 ------NDVQYQGHYY 148
Score = 32.0 bits (71), Expect = 5.9
Identities = 18/64 (28%), Positives = 27/64 (42%), Gaps = 5/64 (7%)
Query: 1305 GNQWRTGPWGSCSSSCSGGLQH---RAVVCQDENGQSASY--CDAASKPPELQQCGPGPC 1359
GN G W CS +C GG + R + ++ GQ+ Y C PP+ + C
Sbjct: 76 GNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCPPDAEDFRAQQC 135
Query: 1360 PQWN 1363
+N
Sbjct: 136 SAYN 139
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 269 bits (687), Expect = 2e-71
Identities = 169/544 (31%), Positives = 249/544 (45%), Gaps = 70/544 (12%)
Query: 551 ETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSC 610
+ R + WGPW +S CSRTCGGG+ R C + R+GG+ CVG RSC T+SC
Sbjct: 21 KVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYS-QRRDGGSSCVGPARSHRSCRTESC 79
Query: 611 PKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLK 670
P G +DFR +QC++F+G RWLP YS ++C+L C G N++Y +
Sbjct: 80 PDGARDFRAEQCAEFDGAEFQ----GRRYRWLPYYSA---PNKCELNCIPKGENFYYKHR 132
Query: 671 DMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFNSS 730
+ V DGTPC D+CV G C GCDH L+SS + DKC CGGD ++C + G F++
Sbjct: 133 EAVVDGTPCEPGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTFDA- 191
Query: 731 HYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNFLFNGNFLLSTSKKEINVQ 790
+D A+ + G + NG++ + ++ +
Sbjct: 192 ----------------------------NDLSRAVKNVRGEYYLNGHWTIEAARA---LP 220
Query: 791 GTRTVIEY---SGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDM 847
T++ Y + + A ER+++ + L++++ + NP VHY +++PL S
Sbjct: 221 AASTILHYERGAEGDLAPERLHARGPTSEPLVIEL--ISQEPNPGVHYEYHLPLRRPSPG 278
Query: 848 FTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCNT-DC- 904
F+W +G W C+ C G Q R + C DH D C P P+ +SCN C
Sbjct: 279 FSWS-HGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQPRPA-DRRSCNLHPCP 334
Query: 905 -ELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYC-GDQLKPPTQELCH 962
RW + CS+ CG G ++ ++C+ S G V++ C G KPP + C+
Sbjct: 335 ETKRWKAGPWAPCSASCGGGSQSRSVYCIS-SDGAGIQEAVEEAECAGLPGKPPAIQACN 393
Query: 963 -GNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSR------VTRE 1015
C W W +CS SCG G R R C G L C R E
Sbjct: 394 LQRC--AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHE 451
Query: 1016 NCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNS--STKPESLSPCE 1073
+C S +W W C +C GT++RQV C + C S +KP + PC
Sbjct: 452 DCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIG----PPSHCGSLQHSKPVDVEPCN 507
Query: 1074 LHTC 1077
C
Sbjct: 508 TQPC 511
Score = 160 bits (404), Expect = 1e-38
Identities = 140/539 (25%), Positives = 202/539 (37%), Gaps = 95/539 (17%)
Query: 972 YSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSRVTRENCNEFSCPSWAASEWS 1031
+S+WS CSR+CGGG RE C + R + C +R R +C SCP A +
Sbjct: 32 WSQWSPCSRTCGGGVSFRERPCYSQ--RRDGGSSCVGPARSHR-SCRTESCPDGARDFRA 88
Query: 1032 E-CLVTCGKGTKQRQV-WCQLNVDHLSDGFCNSSTKPESLSPCELHTCASWQVGPWGPCT 1089
E C G + R+ W + + C + P+ + H A P P
Sbjct: 89 EQCAEFDGAEFQGRRYRWLPY---YSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGK 145
Query: 1090 TTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKLETALLPTVL 1149
R V C +EL S+ ED +C D +C +F + + + V
Sbjct: 146 RDVCVDGSCRVVGCDHELDSSKQED-KCLRCG--GDGTTCYPVAGTFDANDLSRAVKNV- 201
Query: 1150 IKKMAQWRHGSWTPCSVSCGRGTQARYVSC---RDALDRIADESYCAH------------ 1194
+ + +G WT + R A R A +A E A
Sbjct: 202 --RGEYYLNGHWT---IEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELI 256
Query: 1195 --LPRPAEIWDCFTPCGE------WQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYC 1246
P P ++ P W G WS CSA CG G +R V C H+ ++ C
Sbjct: 257 SQEPNPGVHYEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMC 316
Query: 1247 DPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGN 1306
+ RP + C+L CP
Sbjct: 317 QRQPRPADRRSCNLHPCPET---------------------------------------K 337
Query: 1307 QWRTGPWGSCSSSCSGGLQHRAVVCQDENG-------QSASYCDAASKPPELQQCGPGPC 1359
+W+ GPW CS+SC GG Q R+V C +G + A KPP +Q C C
Sbjct: 338 RWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC 397
Query: 1360 PQWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPSVIQCHMHACP--A 1417
W+ WGECS +CG G++ R V C+ G +L C + ++PP C CP +
Sbjct: 398 AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLS 457
Query: 1418 DVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQ--KPPTHKACRSVRC 1474
D +WH W CS SC G + R+V C ++C +Q KP + C + C
Sbjct: 458 DQAWHVGTWGLCSKSCSSGTRRRQVICAIG-----PPSHCGSLQHSKPVDVEPCNTQPC 511
Score = 146 bits (369), Expect = 2e-34
Identities = 123/491 (25%), Positives = 191/491 (38%), Gaps = 75/491 (15%)
Query: 1161 WTPCSVSCGRGTQARYVSCRDALDRIADESYC---AHLPRPAEIWDCFTPCGEWQAGDWS 1217
W+PCS +CG G R C R S C A R C +++A +
Sbjct: 35 WSPCSRTCGGGVSFRERPCYS--QRRDGGSSCVGPARSHRSCRTESCPDGARDFRAEQCA 92
Query: 1218 PCSASCGHGKTTR-----------QVLCM----NYHQP-----IDENYCDPEVRPL-MEQ 1256
+ G+ R ++ C+ N++ +D C+P R + ++
Sbjct: 93 EFDGAEFQGRRYRWLPYYSAPNKCELNCIPKGENFYYKHREAVVDGTPCEPGKRDVCVDG 152
Query: 1257 ECSLAACPPAHSHFPSSPVQPSYYL------STNLPLTQKLEDNENQVVHPSVRGNQWRT 1310
C + C H S Q L +T P+ + N+ +VRG +
Sbjct: 153 SCRVVGC----DHELDSSKQEDKCLRCGGDGTTCYPVAGTFDANDLSRAVKNVRGEYYLN 208
Query: 1311 GPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDA-------ASKPPEL----QQCGPG-- 1357
G W + + L + + E G S+P + Q+ PG
Sbjct: 209 GHW---TIEAARALPAASTILHYERGAEGDLAPERLHARGPTSEPLVIELISQEPNPGVH 265
Query: 1358 ---------PCP--QWNYGNWGECSQTCGGGIKSRLVICQFPNGQILEDHNCEIVNKPPS 1406
P P W++G+W +CS CGGG +SRLV C + + DH C+ +P
Sbjct: 266 YEYHLPLRRPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDH-EAYPDHMCQRQPRPAD 324
Query: 1407 VIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQ----FQRKLEDTNCSQVQ- 1461
C++H CP W PW CSASCG G + R V+CI Q +E+ C+ +
Sbjct: 325 RRSCNLHPCPETKRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPG 384
Query: 1462 KPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCS 1521
KPP +AC RC +W W ECSV+CG GV++R V CR + + C RP
Sbjct: 385 KPPAIQACNLQRCAAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPL 444
Query: 1522 QRRCWSQDC--VQHKGMERGRLN-CSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISL 1578
C +DC + + G CS SC +++ C + ++ +
Sbjct: 445 TEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSK---PV 501
Query: 1579 TSKNCRNPPCN 1589
+ C PC+
Sbjct: 502 DVEPCNTQPCH 512
Score = 134 bits (337), Expect = 8e-31
Identities = 105/387 (27%), Positives = 141/387 (36%), Gaps = 74/387 (19%)
Query: 1024 SWAASEWSECLVTCGKGTKQRQVWCQLNVDHLSDGFCNSSTKPESLSPCELHTCAS---W 1080
SW+ WS+C CG G + R V+C ++ + D C +P C LH C W
Sbjct: 280 SWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
Query: 1081 QVGPWGPCTTTCGHGYQMRDVKCVNELASAV---LEDTECHE-ASRPSDRQSCVLTPCSF 1136
+ GPW PC+ +CG G Q R V C++ + + +E+ EC +P Q+C L C
Sbjct: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRC-- 397
Query: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHLP 1196
A W W CSVSCG G + R V+CR + + C+
Sbjct: 398 -----------------AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLED 440
Query: 1197 RPAEIWDC------FTPCGEWQAGDWSPCSASCGHGKTTRQVLC----------MNYHQP 1240
RP C W G W CS SC G RQV+C + + +P
Sbjct: 441 RPPLTEPCVHEDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKP 500
Query: 1241 IDENYCDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQ--- 1297
+D V P Q C L P+ + P L P D+ Q
Sbjct: 501 VD-------VEPCNTQPCHLPQEVPSMQDVHTPASNPWMPLG---PQESPASDSRGQWWA 550
Query: 1298 -VVHPSVRGNQ--WRTGPWGSCSSSCSG-----GLQHRAVVCQDENGQSASYC------- 1342
HPS RG+ R P G + S LQ +G C
Sbjct: 551 AQEHPSARGDHRGERGDPRGDQGTHLSALGPAPSLQQPPYQQPLRSGSGPHDCRHSPHGC 610
Query: 1343 ----DAASKPPELQQCGPGPCPQWNYG 1365
AS P+ Q C PC Q YG
Sbjct: 611 CPDGHTASLGPQWQGCPGAPCQQSRYG 637
Score = 132 bits (331), Expect = 4e-30
Identities = 80/252 (31%), Positives = 110/252 (43%), Gaps = 34/252 (13%)
Query: 970 WHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNECQELSR-VTRENCNEFSCPS---W 1025
W + WS CS CGGG +SR +C + D+ CQ R R +CN CP W
Sbjct: 281 WSHGSWSDCSAECGGGHQSRLVFCTIDH-EAYPDHMCQRQPRPADRRSCNLHPCPETKRW 339
Query: 1026 AASEWSECLVTCGKGTKQRQVWCQLN-----VDHLSDGFCNSST-KPESLSPCELHTCAS 1079
A W+ C +CG G++ R V+C + + + + C KP ++ C L CA+
Sbjct: 340 KAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCAA 399
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISK 1139
W PWG C+ +CG G + R V C E S +L C RP + CV C +S
Sbjct: 400 WSPEPWGECSVSCGVGVRKRSVTCRGERGS-LLHTAACSLEDRPPLTEPCVHEDCPLLSD 458
Query: 1140 LETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALDRIADESYCAHL--PR 1197
W G+W CS SC GT+ R V C I S+C L +
Sbjct: 459 --------------QAWHVGTWGLCSKSCSSGTRRRQVIC-----AIGPPSHCGSLQHSK 499
Query: 1198 PAEIWDCFT-PC 1208
P ++ C T PC
Sbjct: 500 PVDVEPCNTQPC 511
Score = 88.2 bits (217), Expect = 7e-17
Identities = 66/248 (26%), Positives = 94/248 (37%), Gaps = 30/248 (12%)
Query: 1476 SWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRRCWSQDCVQHKG 1535
SW SW++CS CG G Q R V+C + + MC + RP +R C C + K
Sbjct: 280 SWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYP-DHMCQRQPRPADRRSCNLHPCPETKR 338
Query: 1536 MERGR-LNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSSTISLTSKNCRNPPCNYIVVT 1594
+ G CS SC + + C + + E V + L K CN
Sbjct: 339 WKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQRCA 398
Query: 1595 ADS----SQCANNCGFSYRQRITYCTEIPSTKKH--------KLHRLRPIVYQECPVVPS 1642
A S +C+ +CG R+R C + H + P V+++CP++
Sbjct: 399 AWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCVHEDCPLLSD 458
Query: 1643 SQVYQCINSCLHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDL-CLNHLKPGAQ 1701
W VG W CS +C G +RQV C G S L H KP
Sbjct: 459 Q-------------AWHVGTWGLCSKSCSSGTRRRQVICAI--GPPSHCGSLQHSKPVDV 503
Query: 1702 KKCYANDC 1709
+ C C
Sbjct: 504 EPCNTQPC 511
Score = 51.2 bits (121), Expect = 9e-06
Identities = 33/125 (26%), Positives = 50/125 (40%), Gaps = 19/125 (15%)
Query: 1598 SQCANNCGFSYRQRITYCT-EIPSTKKHKLHRL-RPIVYQECPVVPSSQVYQCINSCLHL 1655
S C+ CG ++ R+ +CT + + H R RP + C + P C
Sbjct: 287 SDCSAECGGGHQSRLVFCTIDHEAYPDHMCQRQPRPADRRSCNLHP----------CPET 336
Query: 1656 ATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHL-------KPGAQKKCYAND 1708
WK G W+ CS +CG G R V CI+ G + KP A + C
Sbjct: 337 KRWKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQACNLQR 396
Query: 1709 CKSFT 1713
C +++
Sbjct: 397 CAAWS 401
Score = 37.7 bits (86), Expect = 0.11
Identities = 20/55 (36%), Positives = 27/55 (49%), Gaps = 6/55 (10%)
Query: 1421 WHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQKPPTHKACRSVRCP 1475
W Q W+ CS +CG G +RE C Q D S V +H++CR+ CP
Sbjct: 32 WSQ--WSPCSRTCGGGVSFRERPCYSQ----RRDGGSSCVGPARSHRSCRTESCP 80
Score = 32.3 bits (72), Expect = 4.5
Identities = 18/63 (28%), Positives = 24/63 (38%), Gaps = 5/63 (7%)
Query: 1301 PSVRGNQWRTGPWGS---CSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPG 1357
P VR GPW CS +C GG+ R C + S C ++ + C
Sbjct: 20 PKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQRRDGGSSCVGPAR--SHRSCRTE 77
Query: 1358 PCP 1360
CP
Sbjct: 78 SCP 80
Score = 32.0 bits (71), Expect = 5.9
Identities = 24/79 (30%), Positives = 31/79 (39%), Gaps = 7/79 (8%)
Query: 536 PGMHCRHGLCVNKETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYC 595
PG+H + L + RP G +S CS CGGG +S C + C
Sbjct: 262 PGVHYEYHLPLR-----RPSPGFSWSHGSWSDCSAECGGGHQSRLVFCTIDHEAYPDHMC 316
Query: 596 --VGRRMKFRSCNTDSCPK 612
R RSCN CP+
Sbjct: 317 QRQPRPADRRSCNLHPCPE 335
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 205 bits (522), Expect = 3e-52
Identities = 144/470 (30%), Positives = 226/470 (48%), Gaps = 50/470 (10%)
Query: 80 YRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSD----LRHCFYRGQV 135
Y T +G+ L L +A +A G T W+ + G + L C Y G V
Sbjct: 111 YNVTVFGRDLHLRLRPNARLVAPGATM---------EWQGEKGTTRVEPLLGSCLYVGDV 161
Query: 136 NSQEDYKAV-VSLCGGLTGTFKGQNGEYFLEPIMKA-DGNEYEDGHNKPHLIYRQDLNNS 193
+ +V +S C GL G + + E+F+EP+ K E E G + H++YR+ +
Sbjct: 162 AGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQG--RVHVVYRRPPTSP 219
Query: 194 FLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKR 253
L Q +T + +++ L V++E N + RRH+
Sbjct: 220 PL--------GGPQALDTGASLDSLDSLSRALGVLEEHA------NSSRRRARRHAADDD 265
Query: 254 LISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVM 312
IE+++ D VV HG ++Q Y+LTLM+IV IY D S+G I++V+V++++
Sbjct: 266 Y-----NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIIL 320
Query: 313 IHREEEGPVINFDGAT-TLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNM 371
+ + +I + +L+N C W Q D H +HD A+ +TR+D S M
Sbjct: 321 LSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS----GM 376
Query: 372 LGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKEMKVTKYHVM 430
G + + +C P++SC +N E G SAF +AHE GH LG++HD RC + +V +M
Sbjct: 377 QGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGD-EVRLGSIM 435
Query: 431 APALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCE 490
AP + + WS CS++ ++ +L + +CLLD P + +LPG Y N+QC
Sbjct: 436 APLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPALPQLPGLHYSMNEQCR 493
Query: 491 LAFGPGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPG 537
FG G MC C LWC+ + + C T+ PP DGT C PG
Sbjct: 494 FDFGLGYMMCTAFRTFDPCKQLWCSHPDNPY-FCKTKKGPPLDGTMCAPG 542
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 192 bits (488), Expect = 3e-48
Identities = 138/474 (29%), Positives = 203/474 (42%), Gaps = 69/474 (14%)
Query: 556 NGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNTDSCPKGTQ 615
+G W W P+S CSRTCGGG + RRC + C GR +++R+C+ CP
Sbjct: 33 DGLWDAWGPWSECSRTCGGGASYSLRRCLSSKS------CEGRNIRYRTCSNVDCPPEAG 86
Query: 616 DFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNYFYLLKDMVED 675
DFR +QCS H D+ WLP + + C L CQ GT L V D
Sbjct: 87 DFRAQQCS----AHNDVKHHGQFYEWLPVSND--PDNPCSLKCQAKGTTLVVELAPKVLD 140
Query: 676 GTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTITGVFN---SSHY 732
GT C TE+ D+C+ G C GCDH L S+ K D CGVC GD S+C+ + G + S+
Sbjct: 141 GTRCYTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATK 200
Query: 733 GYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEG-----NFLFNGNFLLSTSKKEI 787
+ VV IP G+ ++ + PD YL +G + G FL+ S +
Sbjct: 201 SDDTVVAIPYGSRHIRL----VLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDF 256
Query: 788 NVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGNLYNPDVHYSFNIPLEERSDM 847
+ ++ +G A + N + +Q + Y P +H +D
Sbjct: 257 QKFPDKEILRMAGPLTADFIVKIRNSGSADSTVQFI----FYQPIIH------RWRETDF 306
Query: 848 FTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLP---LPSFVTQSCNTD 903
F C+ C G Q + C + VV+D+ C + P P Q CN D
Sbjct: 307 FP---------CSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLD 357
Query: 904 -CEL-----------------RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVD 945
C RW + CSS CG G ++ + C++ I +G V+
Sbjct: 358 PCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDI-QGHVTSVE 416
Query: 946 DHYCGDQLKPPTQELCH-GNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFG 998
+ C K P + C+ +C +W EWS C+ +CG G R R C+++ G
Sbjct: 417 EWKCMYTPKMPIAQPCNIFDC--PKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG 468
Score = 114 bits (284), Expect = 1e-24
Identities = 65/192 (33%), Positives = 99/192 (51%), Gaps = 19/192 (9%)
Query: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECH---EASRPSDR-QSCVLTPCS 1135
W+ + PC+ TCG GYQ+ +C + ++ V+ D CH E +P + Q C L PC
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC--RDALDRIA--DESY 1191
S ++P L + +W WT CS SCG G Q+R VSC D + +E
Sbjct: 361 -ASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
Query: 1192 CAHLPR-----PAEIWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENYC 1246
C + P+ P I+DC +W A +WSPC+ +CG G R VLC++ H+ + C
Sbjct: 420 CMYTPKMPIAQPCNIFDC----PKWLAQEWSPCTVTCGQGLRYRVVLCID-HRGMHTGGC 474
Query: 1247 DPEVRPLMEQEC 1258
P+ +P +++EC
Sbjct: 475 SPKTKPHIKEEC 486
Score = 97.4 bits (241), Expect = 1e-19
Identities = 60/193 (31%), Positives = 84/193 (43%), Gaps = 34/193 (17%)
Query: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENG------QSASYCDAASKP-PELQQCGPGP 1358
++WR + CS++C GG Q + C D Q Y KP P+LQ+C P
Sbjct: 299 HRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDP 358
Query: 1359 CP------------------QWNYGNWGECSQTCGGGIKSRLVICQFPNGQ----ILEDH 1396
CP +W W CS +CGGGI+SR V C + Q +E+
Sbjct: 359 CPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEW 418
Query: 1397 NCEIVNKPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTN 1456
C K P C++ CP W + W+ C+ +CG+G +YR V CID R +
Sbjct: 419 KCMYTPKMPIAQPCNIFDCP---KWLAQEWSPCTVTCGQGLRYRVVLCID--HRGMHTGG 473
Query: 1457 CSQVQKPPTHKAC 1469
CS KP + C
Sbjct: 474 CSPKTKPHIKEEC 486
Score = 96.3 bits (238), Expect = 3e-19
Identities = 49/164 (29%), Positives = 75/164 (45%), Gaps = 24/164 (14%)
Query: 1361 QWNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNC----EIVNKPPSVIQCHMHAC 1415
+W ++ CS TCGGG + C + +++ D C E + P + +C++ C
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 1416 PADVS---------------WHQEPWTSCSASCGKGRKYREVFCIDQ----FQRKLEDTN 1456
PA W PWT+CS+SCG G + R V C+++ +E+
Sbjct: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
Query: 1457 CSQVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYC 1500
C K P + C CP W A W+ C+VTCG G++ R V C
Sbjct: 420 CMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 95.9 bits (237), Expect = 3e-19
Identities = 65/212 (30%), Positives = 92/212 (43%), Gaps = 38/212 (17%)
Query: 1211 WQAGDWSPCSASCGHGKTTRQVLC--MNYHQPIDENYCD--PE-VRPLME-QECSLAACP 1264
W+ D+ PCSA+CG G C + ++ + + YC PE ++P + QEC+L CP
Sbjct: 301 WRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPCP 360
Query: 1265 PAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGL 1324
+ + P + HP R W PW +CSSSC GG+
Sbjct: 361 ASDGYKQIMPYD---------------------LYHPLPR---WEATPWTACSSSCGGGI 396
Query: 1325 QHRAVVCQDEN--GQSASY----CDAASKPPELQQCGPGPCPQWNYGNWGECSQTCGGGI 1378
Q RAV C +E+ G S C K P Q C CP+W W C+ TCG G+
Sbjct: 397 QSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGL 456
Query: 1379 KSRLVICQFPNGQILEDHNCEIVNKPPSVIQC 1410
+ R+V+C G + C KP +C
Sbjct: 457 RYRVVLCIDHRG--MHTGGCSPKTKPHIKEEC 486
Score = 93.6 bits (231), Expect = 2e-18
Identities = 64/198 (32%), Positives = 84/198 (42%), Gaps = 35/198 (17%)
Query: 907 RWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYC-----GDQLKPPTQELC 961
RW CS+ CG GY+ C Y + + V D YC + KP QE
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAEC--YDLRSNRVVA--DQYCHYYPENIKPKPKLQECN 355
Query: 962 HGNCVFT----------------RWHYSEWSQCSRSCGGGERSRESYCMNNF--GHRLAD 1003
C + RW + W+ CS SCGGG +SR C+ GH +
Sbjct: 356 LDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSV 415
Query: 1004 NE--CQELSRVT-RENCNEFSCPSWAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDG 1058
E C ++ + CN F CP W A EWS C VTCG+G + R V C +DH + G
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTG 472
Query: 1059 FCNSSTKPESLSPCELHT 1076
C+ TKP C + T
Sbjct: 473 GCSPKTKPHIKEECIVPT 490
Score = 89.0 bits (219), Expect = 4e-17
Identities = 52/199 (26%), Positives = 84/199 (42%), Gaps = 33/199 (16%)
Query: 966 VFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRL-ADNECQELSRVTR-----ENCNE 1019
+ RW +++ CS +CGGG + + C + +R+ AD C + + CN
Sbjct: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
Query: 1020 FSCPS------------------WAASEWSECLVTCGKGTKQRQVWC-----QLNVDHLS 1056
CP+ W A+ W+ C +CG G + R V C Q +V +
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVE 416
Query: 1057 DGFCNSSTKPESLSPCELHTCASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTE 1116
+ C + K PC + C W W PCT TCG G + R V C++ +
Sbjct: 417 EWKCMYTPKMPIAQPCNIFDCPKWLAQEWSPCTVTCGQGLRYRVVLCIDHRG---MHTGG 473
Query: 1117 CHEASRPSDRQSCVL-TPC 1134
C ++P ++ C++ TPC
Sbjct: 474 CSPKTKPHIKEECIVPTPC 492
Score = 78.2 bits (191), Expect = 7e-14
Identities = 55/235 (23%), Positives = 85/235 (36%), Gaps = 72/235 (30%)
Query: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRD-ALDRIADESYCAHLPR---------------- 1197
+WR + PCS +CG G Q C D +R+ + YC + P
Sbjct: 300 RWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNLDPC 359
Query: 1198 PAE-------IWDCFTPCGEWQAGDWSPCSASCGHGKTTRQVLCM-----NYHQPIDENY 1245
PA +D + P W+A W+ CS+SCG G +R V C+ + ++E
Sbjct: 360 PASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWK 419
Query: 1246 CDPEVRPLMEQECSLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRG 1305
C + + Q C++ CP
Sbjct: 420 CMYTPKMPIAQPCNIFDCP----------------------------------------- 438
Query: 1306 NQWRTGPWGSCSSSCSGGLQHRAVVCQDENGQSASYCDAASKPPELQQC-GPGPC 1359
+W W C+ +C GL++R V+C D G C +KP ++C P PC
Sbjct: 439 -KWLAQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEECIVPTPC 492
Score = 50.1 bits (118), Expect = 2e-05
Identities = 29/105 (27%), Positives = 46/105 (43%), Gaps = 6/105 (5%)
Query: 1600 CANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSCLHLATWK 1659
C+++CG + R C E + H + + +C P + Q N W
Sbjct: 388 CSSSCGGGIQSRAVSCVE-EDIQGH----VTSVEEWKCMYTPKMPIAQPCN-IFDCPKWL 441
Query: 1660 VGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKC 1704
+WS C+VTCG G+ R V CI G+ + C KP +++C
Sbjct: 442 AQEWSPCTVTCGQGLRYRVVLCIDHRGMHTGGCSPKTKPHIKEEC 486
Score = 49.3 bits (116), Expect = 4e-05
Identities = 83/370 (22%), Positives = 125/370 (33%), Gaps = 55/370 (14%)
Query: 1364 YGNWGECSQTCGGGIKSRLVIC---QFPNGQILEDHNCEIVNKPPSVIQCHMHACPA--D 1418
+G W ECS+TCGGG L C + G+ + C V+ PP C A D
Sbjct: 39 WGPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQCSAHND 98
Query: 1419 VSWH----------QEPWTSCSASC-GKGRKYREVFCIDQFQRKLEDTNC-SQVQKPPTH 1466
V H +P CS C KG ++ + L+ T C ++
Sbjct: 99 VKHHGQFYEWLPVSNDPDNPCSLKCQAKG----TTLVVELAPKVLDGTRCYTESLDMCIS 154
Query: 1467 KACRSVRCPSWKANSWNE--CSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQRR 1524
C+ V C ++ E C V G G R V + K + P R
Sbjct: 155 GLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLSATKSDDTVVAIPYGSRH 214
Query: 1525 C-----------WSQDCVQHKGMERGRLNCSTSCERKDSHQRMECTDNQI-RQVNEI--- 1569
+Q E + T S + D +I R +
Sbjct: 215 IRLVLKGPDHLYLETKTLQGTKGENSLSSTGTFLVDNSSVDFQKFPDKEILRMAGPLTAD 274
Query: 1570 ----VYNSSTISLTSKNCRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTEIPSTK--- 1622
+ NS + T + P + D C+ CG Y+ C ++ S +
Sbjct: 275 FIVKIRNSGSADSTVQFIFYQPIIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVA 334
Query: 1623 ----KHKLHRLRP-IVYQECPV--VPSSQVYQCI--NSCLH-LATWKVGKWSKCSVTCGI 1672
+ ++P QEC + P+S Y+ I H L W+ W+ CS +CG
Sbjct: 335 DQYCHYYPENIKPKPKLQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGG 394
Query: 1673 GIMKRQVKCI 1682
GI R V C+
Sbjct: 395 GIQSRAVSCV 404
Score = 32.7 bits (73), Expect = 3.5
Identities = 21/63 (33%), Positives = 27/63 (42%), Gaps = 9/63 (14%)
Query: 1209 GEWQA-GDWSPCSASCGHGKTTRQVLCMNYHQPIDENYCDPEVRPLMEQECSLAACPPAH 1267
G W A G WS CS +CG G + C++ C E R + + CS CPP
Sbjct: 34 GLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSC--EGRNIRYRTCSNVDCPPEA 85
Query: 1268 SHF 1270
F
Sbjct: 86 GDF 88
Score = 31.6 bits (70), Expect = 7.8
Identities = 18/54 (33%), Positives = 24/54 (44%), Gaps = 10/54 (18%)
Query: 1311 GPWGSCSSSCSGGLQH---RAVVCQDENGQSASY--CDAASKPPE-----LQQC 1354
GPW CS +C GG + R + + G++ Y C PPE QQC
Sbjct: 40 GPWSECSRTCGGGASYSLRRCLSSKSCEGRNIRYRTCSNVDCPPEAGDFRAQQC 93
>gi|56788359 thrombospondin repeat containing 1 isoform 2 [Homo
sapiens]
Length = 877
Score = 191 bits (486), Expect = 4e-48
Identities = 146/532 (27%), Positives = 219/532 (41%), Gaps = 80/532 (15%)
Query: 595 CVGRRMKFRSCNTDSCPKGTQDFREKQCSDFNGKHLDISGIPSNVRWLPRYSGIGTKDRC 654
C G + R+C+ CP D R QC+ FN + + +W P ++ + RC
Sbjct: 364 CSGESEQLRACSQAPCPPEQPDPRALQCAAFNSQEF----MGQLYQWEP-FTEVQGSQRC 418
Query: 655 KLYCQVAGTNYFYLLKDMVEDGTPCGTETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCG 714
+L C+ G ++ + V+DGT C DICV G+C++ GCD +L S + D CGVCG
Sbjct: 419 ELNCRPRGFRFYVRHTEKVQDGTLCQPGAPDICVAGRCLSPGCDGILGSGRRPDGCGVCG 478
Query: 715 GDNSSCKTITG--VFNSSHYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNF 772
GD+S+C+ ++G GY ++ IPAGA + I Q +P +YLAL G
Sbjct: 479 GDDSTCRLVSGNLTDRGGPLGYQKILWIPAGALRLQIAQL----RPSSNYLALRGPGGRS 534
Query: 773 LFNGNFLLSTSKKEINVQGTRTVIEYS------GSNNAVERINSTNRQEKELILQVLCVG 826
+ NGN+ + + + TV Y+ G ++ T + + V +
Sbjct: 535 IINGNWAVDPPG---SYRAGGTVFRYNRPPREEGKGESLSAEGPTTQP-----VDVYMIF 586
Query: 827 NLYNPDVHYSF----------------NIPLEERSDMFTWDPYGPWEGCTKMCQGLQRRN 870
NP V Y + +P + + P P + LQR+
Sbjct: 587 QEENPGVFYQYVISSPPPILENPTPEPPVPQLQPEILRVEPPLAPAPRPARTPGTLQRQ- 645
Query: 871 ITCIHKSDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHVIGKSECSSQCGQGYRTLDIH 930
+P P + W +G S CS+ CG+G
Sbjct: 646 --------------VRIPQMPAPPHPRTPLGSPAAY-WKRVGHSACSASCGKGVWRPIFL 690
Query: 931 CMKYSIHEGQTVQVDDHYCGDQLKPP-TQELCHGNCVFTRWHYSEWSQCSRSCGGGERSR 989
C+ E ++D+ C +PP + E CHG W EW+ CSRSCG G + R
Sbjct: 691 CISRESGE----ELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSCSRSCGPGTQHR 746
Query: 990 ESYCMNNF---GHRLADNECQELSRVT-RENCNEFSCPSW-AASEWSECLVTCGKGTKQR 1044
+ C F G + C L R ++C C W S WS+C V CG+G + R
Sbjct: 747 QLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSR 806
Query: 1045 QVWC-QLNVDHLSDGFCNSS-TKPESLSPCELHTCASWQVGPWGPCTTTCGH 1094
QV C N D +S+ C S +P S C++ GPCTT H
Sbjct: 807 QVRCVGNNGDEVSEQECASGPPQPPSREACDM-----------GPCTTAWFH 847
Score = 99.8 bits (247), Expect = 2e-20
Identities = 63/224 (28%), Positives = 90/224 (40%), Gaps = 33/224 (14%)
Query: 970 WHYSEWSQCSRSCGGGERSRESYCMNN-FGHRLADNECQELSR--VTRENCNEFSCPS-W 1025
W S CS SCG G C++ G L + C +R + E C+ CP W
Sbjct: 668 WKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYW 727
Query: 1026 AASEWSECLVTCGKGTKQRQVWCQLNV----DHLSDGFCNSSTKPESLSPCELHTCASWQ 1081
A EW+ C +CG GT+ RQ+ C+ + C +P C+L C W+
Sbjct: 728 EAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWE 787
Query: 1082 VG-PWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPCSFISKL 1140
VG PW C+ CG G + R V+CV V E +P R++C + PC+
Sbjct: 788 VGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCT----- 842
Query: 1141 ETALLPTVLIKKMAQWRHGSWT------PCSVSCGRGTQARYVS 1178
W H W+ P ++SC G A+ S
Sbjct: 843 -------------TAWFHSDWSSKVSPEPPAISCILGNHAQDTS 873
Score = 96.7 bits (239), Expect = 2e-19
Identities = 64/209 (30%), Positives = 84/209 (40%), Gaps = 27/209 (12%)
Query: 1078 ASWQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRP-SDRQSCVLTPCSF 1136
A W+ C+ +CG G C++ + L++ C +RP + + C TPC
Sbjct: 666 AYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCP- 724
Query: 1137 ISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDAL---DRIADESYCA 1193
W G WT CS SCG GTQ R + CR C
Sbjct: 725 -----------------PYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG 767
Query: 1194 HLPRPAEIWDC-FTPCGEWQAGD-WSPCSASCGHGKTTRQVLCM-NYHQPIDENYC-DPE 1249
HLPRP C CG W+ G WS CS CG G+ +RQV C+ N + E C
Sbjct: 768 HLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGP 827
Query: 1250 VRPLMEQECSLAACPPAHSHFP-SSPVQP 1277
+P + C + C A H SS V P
Sbjct: 828 PQPPSREACDMGPCTTAWFHSDWSSKVSP 856
Score = 94.7 bits (234), Expect = 7e-19
Identities = 55/190 (28%), Positives = 87/190 (45%), Gaps = 9/190 (4%)
Query: 1348 PPELQQCGPGPCPQWNYGNWGECSQTCGGGIKSRLVIC-QFPNGQILEDHNCEIVNKPPS 1406
PP + P W CS +CG G+ + +C +G+ L++ +C +PP+
Sbjct: 654 PPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPA 713
Query: 1407 VIQ-CHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQF---QRKLEDTNCSQVQK 1462
+ CH CP W WTSCS SCG G ++R++ C +F + C + +
Sbjct: 714 SPEPCHGTPCPP--YWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPR 771
Query: 1463 PPTHKACRSVRCPSWKANS-WNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQS-TRPC 1520
P ++C+ C W+ S W++CSV CG G + R V C +V E+ C +P
Sbjct: 772 PNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPP 831
Query: 1521 SQRRCWSQDC 1530
S+ C C
Sbjct: 832 SREACDMGPC 841
Score = 92.0 bits (227), Expect = 5e-18
Identities = 67/233 (28%), Positives = 84/233 (36%), Gaps = 53/233 (22%)
Query: 1206 TPCGEWQAGDWSPCSASCGHGKTTRQVLCMNYH--QPIDENYCDPEVRPLMEQE-CSLAA 1262
+P W+ S CSASCG G LC++ + +DE C RP E C
Sbjct: 663 SPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTP 722
Query: 1263 CPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSCSG 1322
CPP W G W SCS SC
Sbjct: 723 CPP-----------------------------------------YWEAGEWTSCSRSCGP 741
Query: 1323 GLQHRAVVCQDENGQSAS-----YCDAASKPPELQQCGPGPCPQWNYGN-WGECSQTCGG 1376
G QHR + C+ E G S C +P Q C C W G+ W +CS CG
Sbjct: 742 GTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGR 801
Query: 1377 GIKSRLVICQFPNGQILEDHNCEI-VNKPPSVIQCHMHACPADVSWHQEPWTS 1428
G +SR V C NG + + C +PPS C M C +W W+S
Sbjct: 802 GQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPC--TTAWFHSDWSS 852
Score = 85.5 bits (210), Expect = 5e-16
Identities = 64/234 (27%), Positives = 84/234 (35%), Gaps = 55/234 (23%)
Query: 1147 TVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC--RDALDRIADESYCAHLPRPAEIWDC 1204
T L A W+ + CS SCG+G C R++ + + + S A PA C
Sbjct: 659 TPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPC 718
Query: 1205 F-TPCGE-WQAGDWSPCSASCGHGKTTRQVLCMNYH----QPIDENYCDPEVRPLMEQEC 1258
TPC W+AG+W+ CS SCG G RQ+ C + C RP + Q C
Sbjct: 719 HGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSC 778
Query: 1259 SLAACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTG-PWGSCS 1317
L C W G PW CS
Sbjct: 779 QLRLC------------------------------------------GHWEVGSPWSQCS 796
Query: 1318 SSCSGGLQHRAVVCQDENGQSASYCDAAS---KPPELQQCGPGPC-PQWNYGNW 1367
C G + R V C NG S + AS +PP + C GPC W + +W
Sbjct: 797 VRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDW 850
Score = 77.4 bits (189), Expect = 1e-13
Identities = 49/155 (31%), Positives = 74/155 (47%), Gaps = 9/155 (5%)
Query: 1421 WHQEPWTSCSASCGKGRKYREVF-CIDQFQ-RKLEDTNCSQVQKPPTH-KACRSVRCPS- 1476
W + ++CSASCGKG +R +F CI + +L++ +C+ +PP + C CP
Sbjct: 668 WKRVGHSACSASCGKG-VWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPY 726
Query: 1477 WKANSWNECSVTCGSGVQQRDVYCRLK---GVGQVVEEMCDQSTRPCSQRRCWSQDCVQH 1533
W+A W CS +CG G Q R + CR + G V E C RP + C + C H
Sbjct: 727 WEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPNITQSCQLRLC-GH 785
Query: 1534 KGMERGRLNCSTSCERKDSHQRMECTDNQIRQVNE 1568
+ CS C R +++ C N +V+E
Sbjct: 786 WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSE 820
Score = 71.6 bits (174), Expect = 7e-12
Identities = 50/179 (27%), Positives = 78/179 (43%), Gaps = 9/179 (5%)
Query: 859 CTKMC-QGLQRRNITCIHKSDHSVVSDKECDHLPLPSFVTQSCN-TDCELRWHVIGKSEC 916
C+ C +G+ R CI + + ++ C P + C+ T C W + C
Sbjct: 676 CSASCGKGVWRPIFLCISRESGEELDERSCAAGARPPASPEPCHGTPCPPYWEAGEWTSC 735
Query: 917 SSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHY-SEW 975
S CG G + + C + G +V + CG +P + C + W S W
Sbjct: 736 SRSCGPGTQHRQLQCRQEFGGGGSSVPPE--RCGHLPRPNITQSCQLR-LCGHWEVGSPW 792
Query: 976 SQCSRSCGGGERSRESYCMNNFGHRLADNECQE--LSRVTRENCNEFSC-PSWAASEWS 1031
SQCS CG G+RSR+ C+ N G +++ EC +RE C+ C +W S+WS
Sbjct: 793 SQCSVRCGRGQRSRQVRCVGNNGDEVSEQECASGPPQPPSREACDMGPCTTAWFHSDWS 851
Score = 66.2 bits (160), Expect = 3e-10
Identities = 41/127 (32%), Positives = 61/127 (48%), Gaps = 9/127 (7%)
Query: 854 GPWEGCTKMC-QGLQRRNITCIHK--SDHSVVSDKECDHLPLPSFVTQSCNTDCELRWHV 910
G W C++ C G Q R + C + S V + C HLP P+ +TQSC W V
Sbjct: 730 GEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCGHLPRPN-ITQSCQLRLCGHWEV 788
Query: 911 IGK-SECSSQCGQGYRTLDIHCMKYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTR 969
S+CS +CG+G R+ + C+ + G V + G +PP++E C T
Sbjct: 789 GSPWSQCSVRCGRGQRSRQVRCVG---NNGDEVSEQECASGPP-QPPSREACDMGPCTTA 844
Query: 970 WHYSEWS 976
W +S+WS
Sbjct: 845 WFHSDWS 851
Score = 47.8 bits (112), Expect = 1e-04
Identities = 37/139 (26%), Positives = 58/139 (41%), Gaps = 27/139 (19%)
Query: 1583 CRNPPCNYIVVTADSSQCANNCGFSYRQRITYCTE--------IPSTKKHKLHRLRPIVY 1634
C PC + + C+ +CG + R C + +P + H RP +
Sbjct: 718 CHGTPCPPYWEAGEWTSCSRSCGPGTQHRQLQCRQEFGGGGSSVPPERCG--HLPRPNIT 775
Query: 1635 QECPVVPSSQVYQCINSCLHLATWKVGK-WSKCSVTCGIGIMKRQVKCITKHG--LSSDL 1691
Q C + C H W+VG WS+CSV CG G RQV+C+ +G +S
Sbjct: 776 QSCQ----------LRLCGH---WEVGSPWSQCSVRCGRGQRSRQVRCVGNNGDEVSEQE 822
Query: 1692 CLN-HLKPGAQKKCYANDC 1709
C + +P +++ C C
Sbjct: 823 CASGPPQPPSREACDMGPC 841
Score = 47.0 bits (110), Expect = 2e-04
Identities = 41/172 (23%), Positives = 63/172 (36%), Gaps = 26/172 (15%)
Query: 1459 QVQKPPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEE-MCDQST 1517
Q+ PP + WK + CS +CG GV + C + G+ ++E C
Sbjct: 650 QMPAPPHPRTPLGSPAAYWKRVGHSACSASCGKGVWRPIFLCISRESGEELDERSCAAGA 709
Query: 1518 R-PCSQRRCWSQDCVQHKGMERGR-LNCSTSCERKDSHQRMECTDNQIRQVNEIVYNSST 1575
R P S C C + E G +CS SC H++++C +
Sbjct: 710 RPPASPEPCHGTPCPPY--WEAGEWTSCSRSCGPGTQHRQLQCRQE---------FGGGG 758
Query: 1576 ISLTSKNCRNPP------------CNYIVVTADSSQCANNCGFSYRQRITYC 1615
S+ + C + P C + V + SQC+ CG R R C
Sbjct: 759 SSVPPERCGHLPRPNITQSCQLRLCGHWEVGSPWSQCSVRCGRGQRSRQVRC 810
Score = 41.6 bits (96), Expect = 0.007
Identities = 14/30 (46%), Positives = 20/30 (66%)
Query: 557 GEWGPWEPYSSCSRTCGGGIESATRRCNRP 586
G WGPW ++SCS+ CG G++ +R C P
Sbjct: 45 GVWGPWVQWASCSQPCGVGVQRRSRTCQLP 74
Score = 35.8 bits (81), Expect = 0.41
Identities = 16/39 (41%), Positives = 20/39 (51%), Gaps = 1/39 (2%)
Query: 1355 GPGPCPQWN-YGNWGECSQTCGGGIKSRLVICQFPNGQI 1392
G GP W + W CSQ CG G++ R CQ P Q+
Sbjct: 40 GQGPEGVWGPWVQWASCSQPCGVGVQRRSRTCQLPTVQL 78
Score = 34.3 bits (77), Expect = 1.2
Identities = 30/99 (30%), Positives = 35/99 (35%), Gaps = 13/99 (13%)
Query: 1276 QPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGP---------WGSCSSSCSGGLQH 1326
+P YL L L Q D E H + GP W SCS C G+Q
Sbjct: 7 RPWLYLLLLLSLPQLCLDQEVLSGHSLQTPTEEGQGPEGVWGPWVQWASCSQPCGVGVQR 66
Query: 1327 RAVVCQDENGQSASYCDAASKPPE----LQQCGPGPCPQ 1361
R+ CQ Q +PP L G GP PQ
Sbjct: 67 RSRTCQLPTVQLHPSLPLPPRPPRHPEALLPRGQGPRPQ 105
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.134 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 86,775,351
Number of Sequences: 37866
Number of extensions: 4463883
Number of successful extensions: 14056
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 84
Number of HSP's successfully gapped in prelim test: 61
Number of HSP's that attempted gapping in prelim test: 9600
Number of HSP's gapped (non-prelim): 1582
length of query: 1910
length of database: 18,247,518
effective HSP length: 117
effective length of query: 1793
effective length of database: 13,817,196
effective search space: 24774232428
effective search space used: 24774232428
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.